-- dump date 20140619_051600 -- class Genbank::misc_feature -- table misc_feature_note -- id note 1310161000001 chromosomal replication initiator protein DnaA; Region: DnaA; TIGR00362 1310161000002 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 1310161000003 Walker A motif; other site 1310161000004 ATP binding site [chemical binding]; other site 1310161000005 Walker B motif; other site 1310161000006 arginine finger; other site 1310161000007 C-terminal domain of bacterial DnaA proteins. The DNA-binding C-terminal domain of DnaA contains a helix-turn-helix motif that specifically interacts with the DnaA box, a 9-mer motif that occurs repetitively in the replication origin oriC. Multiple...; Region: Bac_DnaA_C; cd06571 1310161000008 DnaA box-binding interface [nucleotide binding]; other site 1310161000009 DNA polymerase III subunit beta; Validated; Region: PRK07761 1310161000010 Beta clamp domain. The beta subunit (processivity factor) of DNA polymerase III holoenzyme, refered to as the beta clamp, forms a ring shaped dimer that encircles dsDNA (sliding clamp) in bacteria. The beta-clamp is structurally similar to the trimeric...; Region: beta_clamp; cd00140 1310161000011 putative DNA binding surface [nucleotide binding]; other site 1310161000012 dimer interface [polypeptide binding]; other site 1310161000013 beta-clamp/clamp loader binding surface; other site 1310161000014 beta-clamp/translesion DNA polymerase binding surface; other site 1310161000015 recombination protein F; Reviewed; Region: recF; PRK00064 1310161000016 ATP-binding cassette domain of RecF; Region: ABC_RecF; cd03242 1310161000017 Walker A/P-loop; other site 1310161000018 ATP binding site [chemical binding]; other site 1310161000019 Q-loop/lid; other site 1310161000020 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 1310161000021 ABC transporter signature motif; other site 1310161000022 Walker B; other site 1310161000023 D-loop; other site 1310161000024 H-loop/switch region; other site 1310161000025 hypothetical protein; Provisional; Region: PRK00111 1310161000026 DNA gyrase subunit B; Validated; Region: gyrB; PRK05644 1310161000027 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1310161000028 ATP binding site [chemical binding]; other site 1310161000029 Mg2+ binding site [ion binding]; other site 1310161000030 G-X-G motif; other site 1310161000031 TopoIIA_Trans_DNA_gyrase: Transducer domain, having a ribosomal S5 domain 2-like fold, of the type found in proteins of the type IIA family of DNA topoisomerases similar to the B subunits of E. coli DNA gyrase and E. coli Topoisomerase IV which are; Region: TopoII_Trans_DNA_gyrase; cd00822 1310161000032 anchoring element; other site 1310161000033 dimer interface [polypeptide binding]; other site 1310161000034 ATP binding site [chemical binding]; other site 1310161000035 TOPRIM_TopoIIA_GyrB: topoisomerase-primase (TOPRIM) nucleotidyl transferase/hydrolase domain of the type found in proteins of the type IIA family of DNA topoisomerases similar to the Escherichia coli GyrB subunit. TopoIIA enzymes cut both strands of the...; Region: TOPRIM_TopoIIA_GyrB; cd03366 1310161000036 active site 1310161000037 putative metal-binding site [ion binding]; other site 1310161000038 DNA gyrase B subunit, carboxyl terminus; Region: DNA_gyraseB_C; pfam00986 1310161000039 Predicted alpha/beta hydrolase [General function prediction only]; Region: COG4757 1310161000040 Putative lysophospholipase; Region: Hydrolase_4; pfam12146 1310161000041 Predicted membrane protein [Function unknown]; Region: COG2364 1310161000042 Uncharacterized BCR, YitT family COG1284; Region: DUF161; pfam02588 1310161000043 DNA gyrase subunit A; Validated; Region: PRK05560 1310161000044 DNA Topoisomerase, subtype IIA; domain A'; bacterial DNA topoisomerase IV (C subunit, ParC), bacterial DNA gyrases (A subunit, GyrA),mammalian DNA toposiomerases II. DNA topoisomerases are essential enzymes that regulate the conformational changes...; Region: TOP4c; cd00187 1310161000045 CAP-like domain; other site 1310161000046 active site 1310161000047 primary dimer interface [polypeptide binding]; other site 1310161000048 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 1310161000049 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 1310161000050 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 1310161000051 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 1310161000052 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 1310161000053 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 1310161000054 Transmembrane domain of unknown function (DUF3566); Region: DUF3566; pfam12089 1310161000055 Predicted membrane protein [Function unknown]; Region: COG2855 1310161000056 Transcriptional regulator [Transcription]; Region: LysR; COG0583 1310161000057 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 1310161000058 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 1310161000059 dimerization interface [polypeptide binding]; other site 1310161000060 Cytochrome c biogenesis protein [Posttranslational modification, protein turnover, chaperones]; Region: CcdA; COG0785 1310161000061 Cytochrome C biogenesis protein transmembrane region; Region: DsbD; cl15788 1310161000062 DSBA-like thioredoxin domain; Region: DSBA; pfam01323 1310161000063 Protein Disulfide Oxidoreductases and Other Proteins with a Thioredoxin fold; Region: Thioredoxin_like; cl00388 1310161000064 Predicted transcriptional regulator [Transcription]; Region: COG3682 1310161000065 Zn-dependent protease with chaperone function [Posttranslational modification, protein turnover, chaperones]; Region: HtpX; COG0501 1310161000066 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cl00470 1310161000070 peroxiredoxin, Ohr subfamily; Region: organ_hyd_perox; TIGR03561 1310161000071 Predicted transcriptional regulator containing an HTH domain and an uncharacterized domain shared with the mammalian protein Schlafen [Transcription]; Region: COG2865 1310161000072 Divergent AAA domain; Region: AAA_4; pfam04326 1310161000073 ATP-dependent DNA helicase recG C-terminal; Region: HATPase_c_4; pfam13749 1310161000074 IclR helix-turn-helix domain; Region: HTH_IclR; pfam09339 1310161000075 ABC-type metal ion transport system, periplasmic component/surface adhesin [Inorganic ion transport and metabolism]; Region: LraI; COG0803 1310161000076 Helical backbone metal receptor (TroA-like domain). These proteins have been shown to function in the ABC transport of ferric siderophores and metal ions such as Mn2+, Fe3+, Cu2+ and/or Zn2+. Their ligand binding site is formed in the interface between...; Region: TroA-like; cl00262 1310161000077 intersubunit interface [polypeptide binding]; other site 1310161000078 ABC-type Mn2+/Zn2+ transport systems, permease components [Inorganic ion transport and metabolism]; Region: ZnuB; COG1108 1310161000079 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550 1310161000080 ABC-ATPase subunit interface; other site 1310161000081 dimer interface [polypeptide binding]; other site 1310161000082 putative PBP binding regions; other site 1310161000083 ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136 1310161000084 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 1310161000085 Walker A/P-loop; other site 1310161000086 ATP binding site [chemical binding]; other site 1310161000087 Q-loop/lid; other site 1310161000088 ABC transporter signature motif; other site 1310161000089 Walker B; other site 1310161000090 D-loop; other site 1310161000091 H-loop/switch region; other site 1310161000092 Periplasmic sugar-binding domain of uncharacterized ABC-type transport systems; Region: PBP1_ABC_sugar_binding_like_4; cd06312 1310161000093 Periplasmic binding protein domain; Region: Peripla_BP_4; pfam13407 1310161000094 putative ligand binding site [chemical binding]; other site 1310161000095 Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653 1310161000096 Transmembrane subunit (TM) of Escherichia coli AraH and related proteins. E. coli AraH is the TM of a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of the monosaccharide arabinose. This group...; Region: TM_PBP1_transp_AraH_like; cd06579 1310161000097 TM-ABC transporter signature motif; other site 1310161000098 ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136 1310161000099 First domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_I; cd03216 1310161000100 Walker A/P-loop; other site 1310161000101 ATP binding site [chemical binding]; other site 1310161000102 Q-loop/lid; other site 1310161000103 ABC transporter signature motif; other site 1310161000104 Walker B; other site 1310161000105 D-loop; other site 1310161000106 H-loop/switch region; other site 1310161000107 cyclophilin: cyclophilin-type peptidylprolyl cis- trans isomerases. This family contains eukaryotic, bacterial and archeal proteins which exhibit a peptidylprolyl cis- trans isomerases activity (PPIase, Rotamase) and in addition bind the...; Region: cyclophilin; cd00317 1310161000108 active site 1310161000109 Membrane associated serine protease [Amino acid transport and metabolism]; Region: COG0705 1310161000110 Helix-turn-helix domain; Region: HTH_18; pfam12833 1310161000111 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 1310161000112 Helix-turn-helix domain; Region: HTH_18; pfam12833 1310161000113 ABC-type cobalamin/Fe3+-siderophores transport systems, ATPase components [Inorganic ion transport and metabolism / Coenzyme metabolism]; Region: FepC; COG1120 1310161000114 ATP-binding component of iron-siderophores, vitamin B12 and hemin transporters and related proteins; Region: ABC_Iron-Siderophores_B12_Hemin; cd03214 1310161000115 Walker A/P-loop; other site 1310161000116 ATP binding site [chemical binding]; other site 1310161000117 Q-loop/lid; other site 1310161000118 ABC transporter signature motif; other site 1310161000119 Walker B; other site 1310161000120 D-loop; other site 1310161000121 H-loop/switch region; other site 1310161000122 Siderophore-interacting protein [Inorganic ion transport and metabolism]; Region: ViuB; COG2375 1310161000123 Siderophore interacting proteins share the domain structure of the ferredoxin reductase like family. Siderophores are produced in various bacteria (and some plants) to extract iron from hosts. Binding constants are high, so iron can be pilfered from...; Region: siderophore_interacting; cd06193 1310161000124 FAD binding pocket [chemical binding]; other site 1310161000125 FAD binding motif [chemical binding]; other site 1310161000126 phosphate binding motif [ion binding]; other site 1310161000127 NAD binding pocket [chemical binding]; other site 1310161000128 putative septation inhibitor protein; Reviewed; Region: PRK00159 1310161000129 Protein Kinases, catalytic domain; Region: PKc_like; cl09925 1310161000130 Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220 1310161000131 active site 1310161000132 ATP binding site [chemical binding]; other site 1310161000133 substrate binding site [chemical binding]; other site 1310161000134 activation loop (A-loop); other site 1310161000135 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2815 1310161000136 PASTA domain of bacterial serine/threonine kinase pknB-like proteins. PknB is a member of a group of related transmembrane sensor kinases present in many gram positive bacteria, which has been shown to regulate cell shape in Mycobacterium tubercolosis; Region: PASTA_pknB; cd06577 1310161000137 PASTA domain of bacterial serine/threonine kinase pknB-like proteins. PknB is a member of a group of related transmembrane sensor kinases present in many gram positive bacteria, which has been shown to regulate cell shape in Mycobacterium tubercolosis; Region: PASTA_pknB; cd06577 1310161000138 PASTA domain of bacterial serine/threonine kinase pknB-like proteins. PknB is a member of a group of related transmembrane sensor kinases present in many gram positive bacteria, which has been shown to regulate cell shape in Mycobacterium tubercolosis; Region: PASTA_pknB; cd06577 1310161000139 PASTA domain. This domain is found at the C-termini of several Penicillin-binding proteins (PBPs) and bacterial serine/threonine kinases. It is a small globular fold consisting of 3 beta-sheets and an alpha-helix. The name PASTA is derived from PBP and...; Region: PASTA; cl02768 1310161000140 Protein Kinases, catalytic domain; Region: PKc_like; cl09925 1310161000141 Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220 1310161000142 active site 1310161000143 ATP binding site [chemical binding]; other site 1310161000144 substrate binding site [chemical binding]; other site 1310161000145 activation loop (A-loop); other site 1310161000146 Cell division protein FtsI/penicillin-binding protein 2 [Cell envelope biogenesis, outer membrane]; Region: FtsI; COG0768 1310161000147 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; pfam00905 1310161000148 Bacterial cell division membrane protein [Cell division and chromosome partitioning]; Region: FtsW; COG0772 1310161000149 Protein phosphatase 2C; Region: PP2C; pfam00481 1310161000150 Serine/threonine phosphatases, family 2C, catalytic domain; The protein architecture and deduced catalytic mechanism of PP2C phosphatases are similar to the PP1, PP2A, PP2B family of protein Ser/Thr phosphatases, with which PP2C shares no sequence...; Region: PP2Cc; cd00143 1310161000151 active site 1310161000152 FOG: FHA domain [Signal transduction mechanisms]; Region: COG1716 1310161000153 Forkhead associated domain (FHA); found in eukaryotic and prokaryotic proteins. Putative nuclear signalling domain. FHA domains may bind phosphothreonine, phosphoserine and sometimes phosphotyrosine. In eukaryotes, many FHA domain-containing proteins...; Region: FHA; cd00060 1310161000154 phosphopeptide binding site; other site 1310161000155 Protein of unknown function (DUF2662); Region: DUF3662; pfam12401 1310161000156 FOG: FHA domain [Signal transduction mechanisms]; Region: COG1716 1310161000157 Forkhead associated domain (FHA); found in eukaryotic and prokaryotic proteins. Putative nuclear signalling domain. FHA domains may bind phosphothreonine, phosphoserine and sometimes phosphotyrosine. In eukaryotes, many FHA domain-containing proteins...; Region: FHA; cd00060 1310161000158 phosphopeptide binding site; other site 1310161000159 succinic semialdehyde dehydrogenase; Region: PLN02278 1310161000160 Mitochondrial succinate-semialdehyde dehydrogenase and ALDH family members 5A1 and 5F1-like; Region: ALDH_F5_SSADH_GabD; cd07103 1310161000161 tetramerization interface [polypeptide binding]; other site 1310161000162 NAD(P) binding site [chemical binding]; other site 1310161000163 catalytic residues [active] 1310161000165 Zn-dependent hydrolases, including glyoxylases [General function prediction only]; Region: GloB; COG0491 1310161000166 Rhodanese Homology Domain (RHOD); an alpha beta fold domain found duplicated in the rhodanese protein. The cysteine containing enzymatically active version of the domain is also found in the Cdc25 class of protein phosphatases and a variety of proteins...; Region: RHOD; cd00158 1310161000167 Rhodanese Homology Domain (RHOD); an alpha beta fold domain found duplicated in the rhodanese protein. The cysteine containing enzymatically active version of the domain is also found in the Cdc25 class of protein phosphatases and a variety of proteins...; Region: RHOD; cd00158 1310161000168 active site residue [active] 1310161000169 Sulfite exporter TauE/SafE; Region: TauE; pfam01925 1310161000170 Rhodanese Homology Domain (RHOD); an alpha beta fold domain found duplicated in the rhodanese protein. The cysteine containing enzymatically active version of the domain is also found in the Cdc25 class of protein phosphatases and a variety of proteins...; Region: RHOD; cd00158 1310161000171 active site residue [active] 1310161000172 Rhodanese Homology Domain (RHOD); an alpha beta fold domain found duplicated in the rhodanese protein. The cysteine containing enzymatically active version of the domain is also found in the Cdc25 class of protein phosphatases and a variety of proteins...; Region: RHOD; cd00158 1310161000173 active site residue [active] 1310161000174 Transcriptional regulators CsoR (copper-sensitive operon repressor), RcnR, and FrmR, and related domains; this domain superfamily was previously known as DUF156; Region: CsoR-like_DUF156; cd10148 1310161000175 putative homodimer interface [polypeptide binding]; other site 1310161000176 putative homotetramer interface [polypeptide binding]; other site 1310161000177 putative allosteric switch controlling residues; other site 1310161000178 putative metal binding site [ion binding]; other site 1310161000179 putative homodimer-homodimer interface [polypeptide binding]; other site 1310161000180 MgtC family; Region: MgtC; pfam02308 1310161000181 CotH protein; Region: CotH; pfam08757 1310161000182 Mg2+ and Co2+ transporters [Inorganic ion transport and metabolism]; Region: CorA; COG0598 1310161000183 Mycobacterium tuberculosis CorA-like subfamily; Region: MtCorA-like; cd12830 1310161000184 oligomer interface [polypeptide binding]; other site 1310161000185 metal binding site [ion binding]; metal-binding site 1310161000186 metal binding site [ion binding]; metal-binding site 1310161000187 putative Cl binding site [ion binding]; other site 1310161000188 basic sphincter; other site 1310161000189 hydrophobic gate; other site 1310161000190 periplasmic entrance; other site 1310161000191 Uncharacterized protein, 4-oxalocrotonate tautomerase homolog [General function prediction only]; Region: COG1942 1310161000192 4-Oxalocrotonate Tautomerase: Catalyzes the isomerization of unsaturated ketones. The structure is a homohexamer that is arranged as a trimer of dimers. The hexamer contains six active sites, each formed by residues from three monomers, two from one...; Region: 4Oxalocrotonate_Tautomerase; cl00235 1310161000193 dimer interface [polypeptide binding]; other site 1310161000194 hexamer interface [polypeptide binding]; other site 1310161000195 active site 2 [active] 1310161000196 Nicotinamide mononucleotide transporter [Coenzyme metabolism]; Region: PnuC; COG3201 1310161000197 NYN ribonuclease and ATPase of PhoH family domains [General function prediction only]; Region: COG1875 1310161000198 PIN domain of bacterial Smg6-like homologs with PhoH-like ATPase domains; Region: PIN_PhoHL-ATPase; cd09883 1310161000199 putative active site [active] 1310161000200 PhoH-like protein; Region: PhoH; pfam02562 1310161000201 H+/citrate symporter [Energy production and conversion]; Region: CitM; COG2851 1310161000202 Citrate transporter; Region: CitMHS; pfam03600 1310161000203 H+/citrate symporter [Energy production and conversion]; Region: CitM; cl17620 1310161000204 Signal transduction histidine kinase regulating citrate/malate metabolism [Signal transduction mechanisms]; Region: CitA; COG3290 1310161000205 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1310161000206 ATP binding site [chemical binding]; other site 1310161000207 Mg2+ binding site [ion binding]; other site 1310161000208 G-X-G motif; other site 1310161000209 Response regulator of citrate/malate metabolism [Transcription / Signal transduction mechanisms]; Region: CitB; COG4565 1310161000210 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1310161000211 active site 1310161000212 phosphorylation site [posttranslational modification] 1310161000213 intermolecular recognition site; other site 1310161000214 dimerization interface [polypeptide binding]; other site 1310161000215 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cl17220 1310161000216 putative DNA binding site [nucleotide binding]; other site 1310161000217 putative Zn2+ binding site [ion binding]; other site 1310161000218 Phosphoglycerate dehydrogenase and related dehydrogenases [Amino acid transport and metabolism]; Region: SerA; COG0111 1310161000219 Putative D-isomer specific 2-hydroxyacid dehydrogenases; Region: 2-Hacid_dh_2; cd12159 1310161000220 putative ligand binding site [chemical binding]; other site 1310161000221 putative NAD binding site [chemical binding]; other site 1310161000222 catalytic site [active] 1310161000223 biotin synthase; Validated; Region: PRK06256 1310161000224 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 1310161000225 FeS/SAM binding site; other site 1310161000226 Biotin and Thiamin Synthesis associated domain; Region: BATS; pfam06968 1310161000227 Zinc finger domain containing protein (CHY type) [Function unknown]; Region: COG4357 1310161000228 CHY zinc finger; Region: zf-CHY; pfam05495 1310161000229 drug resistance transporter, EmrB/QacA subfamily; Region: efflux_EmrB; TIGR00711 1310161000230 cytosine deaminase; Provisional; Region: PRK09230 1310161000231 Bacterial cytosine deaminase and related metal-dependent hydrolases. Cytosine deaminases (CDs) catalyze the deamination of cytosine, producing uracil and ammonia. They play an important role in pyrimidine salvage. CDs are present in prokaryotes and fungi; Region: Bact_CD; cd01293 1310161000232 active site 1310161000233 SIR2 superfamily of proteins includes silent information regulator 2 (Sir2) enzymes which catalyze NAD+-dependent protein/histone deacetylation, where the acetyl group from the lysine epsilon-amino group is transferred to the ADP-ribose moiety of NAD+; Region: SIR2; cl00195 1310161000234 NAD-dependent deacetylase; Provisional; Region: PRK05333 1310161000235 Predicted acetyltransferases and hydrolases with the alpha/beta hydrolase fold [General function prediction only]; Region: LipA; COG1075 1310161000236 Lipase (class 2); Region: Lipase_2; pfam01674 1310161000237 Predicted acetyltransferases and hydrolases with the alpha/beta hydrolase fold [General function prediction only]; Region: LipA; COG1075 1310161000238 Lipase (class 2); Region: Lipase_2; pfam01674 1310161000239 helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347 1310161000240 Winged helix DNA-binding domain; Region: HTH_27; pfam13463 1310161000241 Urease gamma-subunit; Urease is a nickel-dependent metalloenzyme that catalyzes the hydrolysis of urea to form ammonia and carbon dioxide. Nickel-dependent ureases are found in bacteria, archaea, fungi and plants. Their primary role is to allow the use...; Region: Urease_gamma; cd00390 1310161000242 alpha-gamma subunit interface [polypeptide binding]; other site 1310161000243 beta-gamma subunit interface [polypeptide binding]; other site 1310161000244 Urease beta-subunit; Urease is a nickel-dependent metalloenzyme that catalyzes the hydrolysis of urea to form ammonia and carbon dioxide. Nickel-dependent ureases are found in bacteria, archaea, fungi and plants. Their primary role is to allow the use of...; Region: Urease_beta; cd00407 1310161000245 gamma-beta subunit interface [polypeptide binding]; other site 1310161000246 alpha-beta subunit interface [polypeptide binding]; other site 1310161000247 urease subunit alpha; Reviewed; Region: ureC; PRK13207 1310161000248 Urease alpha-subunit; Urease is a nickel-dependent metalloenzyme that catalyzes the hydrolysis of urea to form ammonia and carbon dioxide. Nickel-dependent ureases are found in bacteria, fungi and plants. Their primary role is to allow the use of...; Region: Urease_alpha; cd00375 1310161000249 subunit interactions [polypeptide binding]; other site 1310161000250 active site 1310161000251 flap region; other site 1310161000252 Urease accessory protein UreE [Posttranslational modification, protein turnover, chaperones]; Region: UreE; COG2371 1310161000253 UreE urease accessory protein. UreE is a metallochaperone assisting the insertion of a Ni2+ ion in the active site of urease, an important step in the in vivo assembly of urease, an enzyme that hydrolyses urea into ammonia and carbamic acid. The...; Region: UreE; cd00571 1310161000254 dimer interface [polypeptide binding]; other site 1310161000255 catalytic residues [active] 1310161000256 Urease accessory protein UreF [Posttranslational modification, protein turnover, chaperones]; Region: UreF; COG0830 1310161000257 UreF; Region: UreF; pfam01730 1310161000258 The Fer4_NifH superfamily contains a variety of proteins which share a common ATP-binding domain. Functionally, proteins in this superfamily use the energy from hydrolysis of NTP to transfer electron or ion; Region: Fer4_NifH; cl17203 1310161000259 Urease accessory protein UreH [Posttranslational modification, protein turnover, chaperones]; Region: UreH; COG0829 1310161000260 Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596 1310161000261 HSP90 family protein; Provisional; Region: PRK14083 1310161000262 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1310161000263 ATP binding site [chemical binding]; other site 1310161000264 Mg2+ binding site [ion binding]; other site 1310161000265 G-X-G motif; other site 1310161000266 AMP nucleosidase; Region: AMP-nucleosdse; TIGR01717 1310161000267 Bacterial AMP nucleoside phosphorylase N-terminus; Region: AMNp_N; pfam10423 1310161000268 Nucleoside phosphorylase [Nucleotide transport and metabolism]; Region: Pfs; COG0775 1310161000269 Thiamine pyrophosphate-requiring enzymes [acetolactate synthase, pyruvate dehydrogenase (cytochrome), glyoxylate carboligase, phosphonopyruvate decarboxylase] [Amino acid transport and metabolism / Coenzyme metabolism]; Region: IlvB; COG0028 1310161000270 Pyrimidine (PYR) binding domain of POX and related proteins; Region: TPP_PYR_POX_like; cd07035 1310161000271 PYR/PP interface [polypeptide binding]; other site 1310161000272 dimer interface [polypeptide binding]; other site 1310161000273 TPP binding site [chemical binding]; other site 1310161000274 Proline dehydrogenase [Amino acid transport and metabolism]; Region: PutA; COG0506 1310161000275 NAD(P)+-dependent aldehyde dehydrogenase superfamily; Region: ALDH-SF; cl11961 1310161000276 Aldehyde dehydrogenase family; Region: Aldedh; pfam00171 1310161000277 NAD(P) binding site [chemical binding]; other site 1310161000278 catalytic residues [active] 1310161000279 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 1310161000280 Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248 1310161000281 active site 1310161000282 catalytic tetrad [active] 1310161000283 Putative p-aminobenzoyl-glutamate transporter [Coenzyme metabolism]; Region: AbgT; COG2978 1310161000284 M20 Peptidase Aminoacylase 1-like protein 2-like, amidohydrolase subfamily; Region: M20_ACY1L2_like; cd05672 1310161000285 amidohydrolase; Region: amidohydrolases; TIGR01891 1310161000286 metal binding site [ion binding]; metal-binding site 1310161000287 Predicted membrane protein [Function unknown]; Region: COG2149 1310161000288 Domain of unknown function (DUF202); Region: DUF202; pfam02656 1310161000289 Transcriptional regulators of sugar metabolism [Transcription / Carbohydrate transport and metabolism]; Region: GlpR; COG1349 1310161000290 helix_turn_helix, Deoxyribose operon repressor; Region: HTH_DEOR; smart00420 1310161000291 DeoR C terminal sensor domain; Region: DeoRC; pfam00455 1310161000292 This conserved domain belongs to a superfamily including the bleomycin resistance protein, glyoxalase I, and type I ring-cleaving dioxygenases; Region: Glo_EDI_BRP_like_16; cd07263 1310161000293 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 1310161000294 Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067 1310161000295 catalytic core [active] 1310161000296 Mannitol-1-phosphate/altronate dehydrogenases [Carbohydrate transport and metabolism]; Region: MtlD; COG0246 1310161000297 Mannitol dehydrogenase Rossmann domain; Region: Mannitol_dh; pfam01232 1310161000298 Mannitol dehydrogenase C-terminal domain; Region: Mannitol_dh_C; pfam08125 1310161000299 polyol permease family; Region: 2A0118; TIGR00897 1310161000300 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1310161000301 putative substrate translocation pore; other site 1310161000302 Transcriptional regulators of sugar metabolism [Transcription / Carbohydrate transport and metabolism]; Region: GlpR; COG1349 1310161000303 DeoR-like helix-turn-helix domain; Region: HTH_DeoR; pfam08220 1310161000304 DeoR C terminal sensor domain; Region: DeoRC; pfam00455 1310161000305 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cl17037 1310161000306 D-xylulose kinase; Region: XylB; TIGR01312 1310161000307 nucleotide binding site [chemical binding]; other site 1310161000308 Pantoate-beta-alanine ligase; Region: PanC; cd00560 1310161000309 pantoate--beta-alanine ligase; Region: panC; TIGR00018 1310161000310 active site 1310161000311 ATP-binding site [chemical binding]; other site 1310161000312 pantoate-binding site; other site 1310161000313 HXXH motif; other site 1310161000314 Ketopantoate hydroxymethyltransferase (KPHMT) is the first enzyme in the pantothenate biosynthesis pathway. Ketopantoate hydroxymethyltransferase (KPHMT) catalyzes the first committed step in the biosynthesis of pantothenate (vitamin B5), which is a...; Region: KPHMT-like; cd06557 1310161000315 oligomerization interface [polypeptide binding]; other site 1310161000316 active site 1310161000317 metal binding site [ion binding]; metal-binding site 1310161000318 Fic family protein [Function unknown]; Region: COG3177 1310161000319 Fic/DOC family; Region: Fic; pfam02661 1310161000320 Alkyladenine DNA glycosylase catalyzes the first step in base excision repair; Region: AAG; cd00540 1310161000321 active site 1310161000322 DNA binding site [nucleotide binding] 1310161000323 hypothetical protein; Provisional; Region: PRK07758 1310161000324 Domain of unknown function (DU1801); Region: DUF1801; pfam08818 1310161000325 Esterases and lipases (includes fungal lipases, cholinesterases, etc.) These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cd00312 1310161000326 alpha/beta hydrolase fold; Region: Abhydrolase_3; pfam07859 1310161000327 substrate binding pocket [chemical binding]; other site 1310161000328 Haloacid dehalogenase-like hydrolase; Region: HAD_2; pfam13419 1310161000329 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 1310161000330 motif II; other site 1310161000331 Carbonic anhydrases/acetyltransferases, isoleucine patch superfamily [General function prediction only]; Region: PaaY; COG0663 1310161000332 Gamma carbonic anhydrase-like: This family is composed of gamma carbonic anhydrase (CA), Ferripyochelin Binding Protein (FBP), E. coli paaY protein, and similar proteins. CAs are zinc-containing enzymes that catalyze the reversible hydration of carbon...; Region: LbH_gamma_CA_like; cd04645 1310161000333 trimer interface [polypeptide binding]; other site 1310161000334 putative metal binding site [ion binding]; other site 1310161000335 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 1310161000336 putative DNA binding site [nucleotide binding]; other site 1310161000337 Transcriptional regulator/sugar kinase [Transcription / Carbohydrate transport and metabolism]; Region: NagC; COG1940 1310161000338 enterobactin exporter EntS; Provisional; Region: PRK10489 1310161000339 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1310161000340 putative substrate translocation pore; other site 1310161000341 Glycosyltransferases, probably involved in cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: COG1215 1310161000342 CESA_like_2 is a member of the cellulose synthase superfamily; Region: CESA_like_2; cd06427 1310161000343 DXD motif; other site 1310161000344 Dolichyl-phosphate-mannose-protein mannosyltransferase; Region: PMT_2; pfam13231 1310161000345 Ankyrin repeats (3 copies); Region: Ank_2; pfam12796 1310161000346 ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other...; Region: ANK; cd00204 1310161000347 Ankyrin repeats (many copies); Region: Ank_5; pfam13857 1310161000348 Sulfite exporter TauE/SafE; Region: TauE; pfam01925 1310161000349 Predicted permeases [General function prediction only]; Region: RarD; COG2962 1310161000350 Predicted membrane protein [Function unknown]; Region: COG2860 1310161000351 UPF0126 domain; Region: UPF0126; pfam03458 1310161000352 UPF0126 domain; Region: UPF0126; pfam03458 1310161000353 Heat shock protein [Posttranslational modification, protein turnover, chaperones]; Region: HslJ; COG3187 1310161000354 Aspartate alpha-decarboxylase or L-aspartate 1-decarboxylase, a pyruvoyl group-dependent decarboxylase in beta-alanine production; Region: Asp_decarbox; cd06919 1310161000355 tetramerization interface [polypeptide binding]; other site 1310161000356 active site 1310161000357 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4805 1310161000358 Putative ammonia monooxygenase [General function prediction only]; Region: AbrB; COG3180 1310161000359 membrane protein AbrB duplication; Region: Gneg_AbrB_dup; TIGR03082 1310161000360 membrane protein AbrB duplication; Region: Gneg_AbrB_dup; TIGR03082 1310161000361 hypothetical protein; Provisional; Region: PRK10621 1310161000362 Sulfite exporter TauE/SafE; Region: TauE; pfam01925 1310161000363 ATP-dependent helicase HrpB; Region: DEAH_box_HrpB; TIGR01970 1310161000364 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 1310161000365 putative Mg++ binding site [ion binding]; other site 1310161000366 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 1310161000367 nucleotide binding region [chemical binding]; other site 1310161000368 ATP-binding site [chemical binding]; other site 1310161000369 Helicase associated domain (HA2) Add an annotation; Region: HA2; smart00847 1310161000370 Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281 1310161000371 ATP-dependent helicase C-terminal; Region: HrpB_C; pfam08482 1310161000372 maltose O-acetyltransferase; Provisional; Region: PRK10092 1310161000373 Maltose O-acetyltransferase (MAT) and Galactoside O-acetyltransferase (GAT): MAT and GAT catalyze the CoA-dependent acetylation of the 6-hydroxyl group of their respective sugar substrates. MAT acetylates maltose and glucose exclusively at the C6...; Region: LbH_MAT_GAT; cd03357 1310161000374 active site 1310161000375 substrate binding site [chemical binding]; other site 1310161000376 trimer interface [polypeptide binding]; other site 1310161000377 CoA binding site [chemical binding]; other site 1310161000378 2OG-Fe(II) oxygenase superfamily; Region: 2OG-FeII_Oxy_2; pfam13532 1310161000379 Methyladenine glycosylase; Region: Adenine_glyco; pfam03352 1310161000380 Putative threonine efflux protein [Amino acid transport and metabolism]; Region: RhtB; COG1280 1310161000381 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 1310161000382 RNA binding surface [nucleotide binding]; other site 1310161000383 N-terminal domain of Streptomyces griseus SgaA (suppression of growth disturbance caused by A-factor at a high concentration under high osmolality during early growth phase), and similar domains; Region: SgaA_N_like; cd07247 1310161000384 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 1310161000385 N-terminal domain of Streptomyces griseus SgaA (suppression of growth disturbance caused by A-factor at a high concentration under high osmolality during early growth phase), and similar domains; Region: SgaA_N_like; cd07247 1310161000386 The DNA repair protein O6-alkylguanine-DNA alkyltransferase (ATase; also known as AGT, AGAT and MGMT) reverses O6-alkylation DNA damage by transferring O6-alkyl adducts to an active site cysteine irreversibly, without inducing DNA strand breaks. ATases...; Region: ATase; cd06445 1310161000387 DNA binding site [nucleotide binding] 1310161000388 active site 1310161000389 Esterase/lipase [Lipid metabolism]; Region: Aes; COG0657 1310161000390 YjgF, YER057c, and UK114 belong to a large family of proteins present in bacteria, archaea, and eukaryotes with no definitive function. The conserved domain is similar in structure to chorismate mutase but there is no sequence similarity and no...; Region: YjgF_YER057c_UK114_family; cd00448 1310161000391 homotrimer interaction site [polypeptide binding]; other site 1310161000392 putative active site [active] 1310161000393 Predicted metalloendopeptidase [Posttranslational modification, protein turnover, chaperones]; Region: PepO; COG3590 1310161000394 Peptidase family M13 includes neprilysin, endothelin-converting enzyme I; Region: M13; cd08662 1310161000395 active site 1310161000396 Zn binding site [ion binding]; other site 1310161000397 Membrane proteinase, regulator of anti-sigma factor [Posttranslational modification, protein turnover, chaperones]; Region: prsW; COG2339 1310161000398 Transcriptional regulators [Transcription]; Region: PhnF; COG2188 1310161000399 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 1310161000400 DNA-binding site [nucleotide binding]; DNA binding site 1310161000401 UTRA domain; Region: UTRA; pfam07702 1310161000402 2-keto-3-deoxygluconate kinase (KdgK) phosphorylates 2-keto-3-deoxygluconate (KDG) to form 2-keto-3-deoxy-6-phosphogluconate (KDGP). KDG is the common intermediate product, that allows organisms to channel D-glucuronate and/or D-galacturinate into the...; Region: KdgK; cd01166 1310161000403 Sugar kinases, ribokinase family [Carbohydrate transport and metabolism]; Region: RbsK; COG0524 1310161000404 substrate binding site [chemical binding]; other site 1310161000405 ATP binding site [chemical binding]; other site 1310161000406 Methylmalonate semialdehyde dehydrogenase and ALDH family members 6A1 and 6B2; Region: ALDH_F6_MMSDH; cd07085 1310161000407 methylmalonic acid semialdehyde dehydrogenase; Region: MMSDH; TIGR01722 1310161000408 tetrameric interface [polypeptide binding]; other site 1310161000409 NAD binding site [chemical binding]; other site 1310161000410 catalytic residues [active] 1310161000411 Uncharacterized enzyme involved in inositol metabolism [Carbohydrate transport and metabolism]; Region: IolB; COG3718 1310161000412 Acetolactate synthase [Amino acid transport and metabolism]; Region: COG3962 1310161000413 Pyrimidine (PYR) binding domain of POX and related proteins; Region: TPP_PYR_POX_like; cd07035 1310161000414 PYR/PP interface [polypeptide binding]; other site 1310161000415 dimer interface [polypeptide binding]; other site 1310161000416 TPP binding site [chemical binding]; other site 1310161000417 Thiamine pyrophosphate enzyme, central domain; Region: TPP_enzyme_M; pfam00205 1310161000418 Thiamine pyrophosphate (TPP) family, IolD subfamily, TPP-binding module; composed of proteins similar to Rhizobium leguminosarum bv. viciae IolD. IolD plays an important role in myo-inositol catabolism; Region: TPP_IolD; cd02003 1310161000419 TPP-binding site; other site 1310161000420 Sugar phosphate isomerases/epimerases [Carbohydrate transport and metabolism]; Region: IolE; COG1082 1310161000421 Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673 1310161000422 Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408 1310161000423 Oxidoreductase family, C-terminal alpha/beta domain; Region: GFO_IDH_MocA_C; pfam02894 1310161000424 Sugar phosphate isomerases/epimerases [Carbohydrate transport and metabolism]; Region: IolE; COG1082 1310161000425 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1310161000426 putative transporter; Provisional; Region: PRK10504 1310161000427 putative substrate translocation pore; other site 1310161000428 Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673 1310161000429 Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408 1310161000430 Oxidoreductase family, C-terminal alpha/beta domain; Region: GFO_IDH_MocA_C; pfam02894 1310161000431 Antitoxin Phd_YefM, type II toxin-antitoxin system; Region: PhdYeFM_antitox; cl09153 1310161000432 Transcriptional regulators [Transcription]; Region: PurR; COG1609 1310161000433 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 1310161000434 DNA binding site [nucleotide binding] 1310161000435 domain linker motif; other site 1310161000436 Ligand binding domain of the LacI tanscriptional regulator family belonging to the type I periplasmic-binding fold protein superfamily; Region: PBP1_LacI_sugar_binding_like; cd06267 1310161000437 dimerization interface [polypeptide binding]; other site 1310161000438 ligand binding site [chemical binding]; other site 1310161000439 Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408 1310161000440 Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673 1310161000441 Oxidoreductase family, C-terminal alpha/beta domain; Region: GFO_IDH_MocA_C; pfam02894 1310161000442 Sugar phosphate isomerases/epimerases [Carbohydrate transport and metabolism]; Region: IolE; COG1082 1310161000443 Cold-Shock Protein (CSP) contains an S1-like cold-shock domain (CSD) that is found in eukaryotes, prokaryotes, and archaea. CSP's include the major cold-shock proteins CspA and CspB in bacteria and the eukaryotic gene regulatory factor Y-box...; Region: CSP_CDS; cd04458 1310161000444 DNA-binding site [nucleotide binding]; DNA binding site 1310161000445 RNA-binding motif; other site 1310161000446 Transcriptional regulators [Transcription]; Region: MarR; COG1846 1310161000447 Winged helix DNA-binding domain; Region: HTH_34; pfam13601 1310161000450 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 1310161000451 Acetyltransferases [General function prediction only]; Region: RimI; COG0456 1310161000452 Coenzyme A binding pocket [chemical binding]; other site 1310161000453 Transcriptional regulators [Transcription]; Region: PurR; COG1609 1310161000454 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 1310161000455 DNA binding site [nucleotide binding] 1310161000456 domain linker motif; other site 1310161000457 Ligand binding domain of the LacI tanscriptional regulator family belonging to the type I periplasmic-binding fold protein superfamily; Region: PBP1_LacI_sugar_binding_like; cd06267 1310161000458 dimerization interface [polypeptide binding]; other site 1310161000459 ligand binding site [chemical binding]; other site 1310161000460 Sugar (and other) transporter; Region: Sugar_tr; pfam00083 1310161000461 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1310161000462 putative substrate translocation pore; other site 1310161000463 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1310161000464 Transposase and inactivated derivatives, IS30 family [DNA replication, recombination, and repair]; Region: Tra8; COG2826 1310161000465 Helix-turn-helix domain; Region: HTH_38; pfam13936 1310161000466 Homeodomain-like domain; Region: HTH_32; pfam13565 1310161000467 Integrase core domain; Region: rve; pfam00665 1310161000469 glutamate synthase subunit alpha; Provisional; Region: gltB; PRK11750 1310161000470 Glutamine amidotransferases class-II (Gn-AT), glutamate synthase (GltS)-type. GltS is a homodimer that synthesizes L-glutamate from 2-oxoglutarate and L-glutamine, an important step in ammonia assimilation in bacteria, cyanobacteria and plants. The...; Region: GltS; cd00713 1310161000471 active site 1310161000472 dimer interface [polypeptide binding]; other site 1310161000473 Glutamate synthase central domain; Region: Glu_syn_central; pfam04898 1310161000474 Glutamate synthase (GltS) FMN-binding domain. GltS is a complex iron-sulfur flavoprotein that catalyzes the reductive synthesis of L-glutamate from 2-oxoglutarate and L-glutamine via intramolecular channelling of ammonia, a reaction in the plant, yeast...; Region: GltS_FMN; cd02808 1310161000475 active site 1310161000476 FMN binding site [chemical binding]; other site 1310161000477 substrate binding site [chemical binding]; other site 1310161000478 3Fe-4S cluster binding site [ion binding]; other site 1310161000479 gltb_C. This domain is found at the C-terminus of the large subunit (gltB) of glutamate synthase (GltS). GltS encodes a complex iron-sulfur flavoprotein that catalyzes the synthesis of L-glutamate from L-glutamine and 2-oxoglutarate. It requires the...; Region: gltB_C; cd00982 1310161000480 domain interface; other site 1310161000481 glutamate synthase subunit beta; Reviewed; Region: gltD; PRK12810 1310161000482 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450 1310161000483 Glutamate-cysteine ligase family 2(GCS2); Region: GCS2; cl00954 1310161000484 Mycobacterial cell wall arabinan synthesis protein; Region: Arabinose_trans; pfam04602 1310161000485 Arabinofuranosyltransferase N terminal; Region: AftA_N; pfam12250 1310161000486 Arabinofuranosyltransferase A C terminal; Region: AftA_C; pfam12249 1310161000487 short chain dehydrogenase; Provisional; Region: PRK07904 1310161000488 Short-chain dehydrogenases of various substrate specificities [General function prediction only]; Region: DltE; COG0300 1310161000489 NAD(P) binding site [chemical binding]; other site 1310161000490 active site 1310161000491 FAD/FMN-containing dehydrogenases [Energy production and conversion]; Region: GlcD; COG0277 1310161000492 FAD binding domain; Region: FAD_binding_4; pfam01565 1310161000493 D-arabinono-1,4-lactone oxidase; Region: ALO; pfam04030 1310161000494 Plasmid pRiA4b ORF-3-like protein; Region: PRiA4_ORF3; pfam07929 1310161000495 Predicted membrane protein [Function unknown]; Region: COG2246 1310161000496 GtrA-like protein; Region: GtrA; pfam04138 1310161000497 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2258 1310161000498 MOSC domain; Region: MOSC; pfam03473 1310161000499 Predicted glycosyltransferases [General function prediction only]; Region: COG1216 1310161000500 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394 1310161000501 active site 1310161000502 Glyoxalase-like domain; Region: Glyoxalase_3; pfam13468 1310161000503 ABC-type polysaccharide/polyol phosphate transport system, ATPase component [Carbohydrate transport and metabolism / Cell envelope biogenesis, outer membrane]; Region: TagH; COG1134 1310161000504 ATP-binding cassette component of polysaccharide transport system; Region: ABC_KpsT_Wzt; cd03220 1310161000505 Walker A/P-loop; other site 1310161000506 ATP binding site [chemical binding]; other site 1310161000507 Q-loop/lid; other site 1310161000508 ABC transporter signature motif; other site 1310161000509 Walker B; other site 1310161000510 D-loop; other site 1310161000511 H-loop/switch region; other site 1310161000512 ABC-type polysaccharide/polyol phosphate export systems, permease component [Carbohydrate transport and metabolism / Cell envelope biogenesis, outer membrane]; Region: TagG; COG1682 1310161000513 ABC-2 type transporter; Region: ABC2_membrane; pfam01061 1310161000514 Selenocysteine lyase/Cysteine desulfurase [Posttranslational modification, protein turnover, chaperones]; Region: csdA; COG0520 1310161000515 Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321 1310161000516 putative NAD(P)H quinone oxidoreductase, PIG3 family; Region: quinone_pig3; TIGR02824 1310161000517 PIG3 p53-inducible quinone oxidoreductase; Region: p53_inducible_oxidoreductase; cd05276 1310161000518 NAD(P) binding site [chemical binding]; other site 1310161000519 Ferredoxin [Energy production and conversion]; Region: Fdx; COG0633 1310161000520 2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207 1310161000521 catalytic loop [active] 1310161000522 iron binding site [ion binding]; other site 1310161000523 Na+/alanine symporter [Amino acid transport and metabolism]; Region: AlsT; COG1115 1310161000524 Sodium:alanine symporter family; Region: Na_Ala_symp; cl00548 1310161000525 Domain of unknown function (DUF4095); Region: DUF4095; pfam13338 1310161000526 molybdopterin biosynthesis protein MoeB; Validated; Region: PRK05597 1310161000527 ThiF_MoeB_HesA. Family of E1-like enzymes involved in molybdopterin and thiamine biosynthesis family. The common reaction mechanism catalyzed by MoeB and ThiF, like other E1 enzymes, begins with a nucleophilic attack of the C-terminal carboxylate of MoaD...; Region: ThiF_MoeB_HesA_family; cd00757 1310161000528 ATP binding site [chemical binding]; other site 1310161000529 substrate interface [chemical binding]; other site 1310161000530 Rhodanese Homology Domain (RHOD); an alpha beta fold domain found duplicated in the rhodanese protein. The cysteine containing enzymatically active version of the domain is also found in the Cdc25 class of protein phosphatases and a variety of proteins...; Region: RHOD; cd00158 1310161000531 active site residue [active] 1310161000532 MoaE family. Members of this family are involved in biosynthesis of the molybdenum cofactor (Moco), an essential cofactor for a diverse group of redox enzymes. Moco biosynthesis is an evolutionarily conserved pathway present in eubacteria, archaea and...; Region: MoaE; cd00756 1310161000533 MoaE homodimer interface [polypeptide binding]; other site 1310161000534 MoaD interaction [polypeptide binding]; other site 1310161000535 active site residues [active] 1310161000536 MogA_MoaB family. Members of this family are involved in biosynthesis of the molybdenum cofactor (MoCF) an essential cofactor of a diverse group of redox enzymes. MoCF biosynthesis is an evolutionarily conserved pathway present in eubacteria, archaea; Region: MogA_MoaB; cd00886 1310161000537 MPT binding site; other site 1310161000538 trimer interface [polypeptide binding]; other site 1310161000539 MoaC family, prokaryotic and eukaryotic. Members of this family are involved in molybdenum cofactor (Moco) biosynthesis, an essential cofactor of a diverse group of redox enzymes. MoaC, a small hexameric protein, converts, together with MoaA, a guanosine...; Region: MoaC_PE; cd01420 1310161000540 trimer interface [polypeptide binding]; other site 1310161000541 dimer interface [polypeptide binding]; other site 1310161000542 putative active site [active] 1310161000543 Molybdopterin biosynthesis enzyme [Coenzyme metabolism]; Region: MoeA; COG0303 1310161000544 MoeA family. Members of this family are involved in biosynthesis of the molybdenum cofactor (MoCF), an essential cofactor of a diverse group of redox enzymes. MoCF biosynthesis is an evolutionarily conserved pathway present in eubacteria, archaea and...; Region: MoeA; cd00887 1310161000545 dimer interface [polypeptide binding]; other site 1310161000546 putative functional site; other site 1310161000547 putative MPT binding site; other site 1310161000548 ABC-type sulfate transport system, permease component [Posttranslational modification, protein turnover, chaperones]; Region: CysU; COG0555 1310161000549 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1310161000550 dimer interface [polypeptide binding]; other site 1310161000551 conserved gate region; other site 1310161000552 putative PBP binding loops; other site 1310161000553 ABC-ATPase subunit interface; other site 1310161000554 Bacterial extracellular solute-binding protein; Region: SBP_bac_11; pfam13531 1310161000555 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; cl17199 1310161000556 Ubiquitin-like proteins; Region: UBQ; cl00155 1310161000557 charged pocket; other site 1310161000558 hydrophobic patch; other site 1310161000559 ABC-type sugar transport systems, ATPase components [Carbohydrate transport and metabolism]; Region: MalK; COG3839 1310161000560 ATP-binding cassette domain of the carbohydrate and solute transporters-like; Region: ABC_Carb_Solutes_like; cd03259 1310161000561 Walker A/P-loop; other site 1310161000562 ATP binding site [chemical binding]; other site 1310161000563 Q-loop/lid; other site 1310161000564 ABC transporter signature motif; other site 1310161000565 Walker B; other site 1310161000566 D-loop; other site 1310161000567 H-loop/switch region; other site 1310161000568 Predicted membrane protein [Function unknown]; Region: COG1950 1310161000569 Histidinol-phosphate/aromatic aminotransferase and cobyric acid decarboxylase [Amino acid transport and metabolism]; Region: HisC; COG0079 1310161000570 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 1310161000571 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1310161000572 homodimer interface [polypeptide binding]; other site 1310161000573 catalytic residue [active] 1310161000574 Protein of unknown function (DUF3800); Region: DUF3800; pfam12686 1310161000575 Transcriptional regulator [Transcription]; Region: LysR; COG0583 1310161000576 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 1310161000577 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cd05466 1310161000578 dimerization interface [polypeptide binding]; other site 1310161000579 Zn-dependent alcohol dehydrogenases [General function prediction only]; Region: AdhP; COG1064 1310161000580 Cinnamyl alcohol dehydrogenases (CAD); Region: CAD_like; cd08296 1310161000581 putative NAD(P) binding site [chemical binding]; other site 1310161000582 putative substrate binding site [chemical binding]; other site 1310161000583 catalytic Zn binding site [ion binding]; other site 1310161000584 structural Zn binding site [ion binding]; other site 1310161000585 Monoamine oxidase [Amino acid transport and metabolism]; Region: COG1231 1310161000586 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450 1310161000587 Mg/Co/Ni transporter MgtE (contains CBS domain) [Inorganic ion transport and metabolism]; Region: MgtE; COG2239 1310161000588 MgtE intracellular N domain; Region: MgtE_N; smart00924 1310161000589 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domain in the magnesium transporter, MgtE. MgtE and its homologs are found in eubacteria, archaebacteria, and eukaryota. Members of this family transport Mg2+ or other...; Region: CBS_pair_Mg_transporter; cd04606 1310161000590 Divalent cation transporter; Region: MgtE; cl00786 1310161000591 Di- and tricarboxylate transporters [Inorganic ion transport and metabolism]; Region: CitT; COG0471 1310161000592 Permease SLC13 (solute carrier 13). The sodium/dicarboxylate cotransporter NaDC-1 has been shown to translocate Krebs cycle intermediates such as succinate, citrate, and alpha-ketoglutarate across plasma membranes rabbit, human, and rat kidney. It is...; Region: SLC13_permease; cd01115 1310161000593 transmembrane helices; other site 1310161000594 prephenate dehydrogenase; Validated; Region: PRK06545 1310161000595 prephenate dehydrogenase; Validated; Region: PRK08507 1310161000596 putative tRNA adenosine deaminase-associated protein; Region: tRNA_deam_assoc; TIGR03941 1310161000597 Nucleoside deaminases include adenosine, guanine and cytosine deaminases. These enzymes are Zn dependent and catalyze the deamination of nucleosides. The zinc ion in the active site plays a central role in the proposed catalytic mechanism, activating a...; Region: nucleoside_deaminase; cd01285 1310161000598 nucleoside/Zn binding site; other site 1310161000599 dimer interface [polypeptide binding]; other site 1310161000600 catalytic motif [active] 1310161000601 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3237 1310161000602 MMPL family; Region: MMPL; pfam03176 1310161000603 Queuine/archaeosine tRNA-ribosyltransferase [Translation, ribosomal structure and biogenesis]; Region: Tgt; COG0343 1310161000604 queuine tRNA-ribosyltransferase; Provisional; Region: tgt; cl00409 1310161000605 Uncharacterized member of the PurR regulon [General function prediction only]; Region: yhhQ; COG1738 1310161000606 ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132 1310161000607 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 1310161000608 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 1310161000609 Q-loop/lid; other site 1310161000610 ABC transporter signature motif; other site 1310161000611 Walker B; other site 1310161000612 glutamyl-Q tRNA(Asp) synthetase; Reviewed; Region: PRK05710 1310161000613 tRNA synthetases class I (E and Q), catalytic domain; Region: tRNA-synt_1c; pfam00749 1310161000614 active site 1310161000615 HIGH motif; other site 1310161000616 nucleotide binding site [chemical binding]; other site 1310161000617 active site 1310161000618 KMSKS motif; other site 1310161000619 Protocatechuate 3,4-dioxygenase beta subunit [Secondary metabolites biosynthesis, transport, and catabolism]; Region: PcaH; COG3485 1310161000620 Intradiol dioxygenase supgroup. Intradiol dioxygenases catalyze the critical ring-cleavage step in the conversion of catecholate derivatives to citric acid cycle intermediates. They break the catechol C1-C2 bond and utilize Fe3+, as opposed to the...; Region: intradiol_dioxygenase_like; cd03457 1310161000621 putative active site [active] 1310161000622 Integrase core domain; Region: rve; pfam00665 1310161000623 DDE domain; Region: DDE_Tnp_IS240; pfam13610 1310161000624 Integrase core domain; Region: rve_3; pfam13683 1310161000625 Alanine-glyoxylate amino-transferase; Region: Aminotran_MocR; pfam12897 1310161000626 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 1310161000627 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1310161000628 homodimer interface [polypeptide binding]; other site 1310161000629 catalytic residue [active] 1310161000630 Suppressor of fused protein (SUFU); Region: SUFU; pfam05076 1310161000631 DNA polymerase III, subunit gamma and tau; Region: dnaX_nterm; TIGR02397 1310161000632 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 1310161000633 Walker A motif; other site 1310161000634 ATP binding site [chemical binding]; other site 1310161000635 Walker B motif; other site 1310161000636 arginine finger; other site 1310161000637 hypothetical protein; Validated; Region: PRK00153 1310161000638 recombination protein RecR; Reviewed; Region: recR; PRK00076 1310161000639 Helix-hairpin-helix DNA-binding motif class 1; Region: HhH1; smart00278 1310161000640 RecR protein; Region: RecR; pfam02132 1310161000641 TOPRIM_recR: topoisomerase-primase (TOPRIM) nucleotidyl transferase/hydrolase domain of the type found in Escherichia coli RecR. RecR participates in the RecFOR pathway of homologous recombinational repair in prokaryotes. This pathway provides a...; Region: TOPRIM_recR; cd01025 1310161000642 putative active site [active] 1310161000643 putative metal-binding site [ion binding]; other site 1310161000644 tetramer interface [polypeptide binding]; other site 1310161000645 Type 1 glutamine amidotransferase (GATase1) domain found in Cobyric Acid Synthase (CobQ); Region: GATase1_CobQ; cd01750 1310161000646 catalytic triad [active] 1310161000647 UDP-N-acetylmuramyl tripeptide synthase [Cell envelope biogenesis, outer membrane]; Region: MurE; COG0769 1310161000648 Mur ligase middle domain; Region: Mur_ligase_M; pfam08245 1310161000649 Domain of unknown function (DUF1727); Region: DUF1727; pfam08353 1310161000650 DNA polymerase III subunit epsilon; Validated; Region: PRK05601 1310161000651 DEDDh 3'-5' exonuclease domain family; Region: DEDDh; cd06127 1310161000652 2-isopropylmalate synthase; Validated; Region: PRK03739 1310161000653 Mycobacterium tuberculosis LeuA3 and related proteins, N-terminal catalytic TIM barrel domain; Region: DRE_TIM_LeuA; cd07942 1310161000654 active site 1310161000655 catalytic residues [active] 1310161000656 metal binding site [ion binding]; metal-binding site 1310161000657 LeuA allosteric (dimerisation) domain; Region: LeuA_dimer; pfam08502 1310161000658 aspartate kinase; Reviewed; Region: PRK06635 1310161000659 AAK_AKii-LysC-BS: Amino Acid Kinase Superfamily (AAK), AKii; this CD includes the N-terminal catalytic aspartokinase (AK) domain of the lysine-sensitive aspartokinase isoenzyme AKII of Bacillus subtilis 168, and the lysine plus threonine-sensitive...; Region: AAK_AKii-LysC-BS; cd04261 1310161000660 putative nucleotide binding site [chemical binding]; other site 1310161000661 putative catalytic residues [active] 1310161000662 putative Mg ion binding site [ion binding]; other site 1310161000663 putative aspartate binding site [chemical binding]; other site 1310161000664 ACT domains of the lysine-sensitive aspartokinase isoenzyme AKII of Bacillus subtilis (BS) strain 168 and related proteins; Region: ACT_AKii-LysC-BS-like_1; cd04913 1310161000665 putative allosteric regulatory site; other site 1310161000666 ACT domains of the lysine-sensitive, aspartokinase (AK) isoenzyme AKII of Bacillus subtilis (BS) strain 168 and related domains; Region: ACT_AKii-LysC-BS-like_2; cd04936 1310161000667 putative allosteric regulatory residue; other site 1310161000668 aspartate-semialdehyde dehydrogenase; Provisional; Region: PRK14874 1310161000669 Semialdehyde dehydrogenase, NAD binding domain; Region: Semialdhyde_dh; smart00859 1310161000670 RNA polymerase sigma factor; Provisional; Region: PRK12535 1310161000671 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 1310161000672 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 1310161000673 DNA binding residues [nucleotide binding] 1310161000674 Catalase [Inorganic ion transport and metabolism]; Region: KatE; COG0753 1310161000675 Catalase-like heme-binding proteins and protein domains; Region: catalase_like; cl09506 1310161000676 heme binding pocket [chemical binding]; other site 1310161000677 Transcriptional regulators [Transcription]; Region: Lrp; COG1522 1310161000678 Winged helix-turn-helix DNA-binding; Region: HTH_24; pfam13412 1310161000679 AsnC family; Region: AsnC_trans_reg; pfam01037 1310161000680 Predicted branched-chain amino acid permease (azaleucine resistance) [Amino acid transport and metabolism]; Region: AzlC; COG1296 1310161000681 Predicted branched-chain amino acid permeases (azaleucine resistance) [Amino acid transport and metabolism]; Region: AzlD; COG1687 1310161000682 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 1310161000683 dimerization interface [polypeptide binding]; other site 1310161000684 putative DNA binding site [nucleotide binding]; other site 1310161000685 putative Zn2+ binding site [ion binding]; other site 1310161000686 Arsenite efflux pump ACR3 and related permeases [Inorganic ion transport and metabolism]; Region: ACR3; COG0798 1310161000687 arsenical-resistance protein; Region: acr3; TIGR00832 1310161000688 Protein-tyrosine-phosphatase [Signal transduction mechanisms]; Region: Wzb; COG0394 1310161000689 Low molecular weight phosphatase family; Region: LMWPc; cl00105 1310161000690 active site 1310161000691 Multisubunit Na+/H+ antiporter, MnhG subunit [Inorganic ion transport and metabolism]; Region: MnhG; COG1320 1310161000692 putative monovalent cation/H+ antiporter subunit F; Reviewed; Region: PRK12612 1310161000693 putative monovalent cation/H+ antiporter subunit E; Reviewed; Region: PRK12654 1310161000694 putative monovalent cation/H+ antiporter subunit D; Reviewed; Region: PRK08375 1310161000695 NADH-Ubiquinone/plastoquinone (complex I), various chains; Region: Oxidored_q1; pfam00361 1310161000696 putative monovalent cation/H+ antiporter subunit C; Reviewed; Region: PRK07375 1310161000697 putative monovalent cation/H+ antiporter subunit A; Reviewed; Region: PRK12650 1310161000698 NADH-Ubiquinone/plastoquinone (complex I), various chains; Region: Oxidored_q1; pfam00361 1310161000699 Domain of unknown function (DUF4040); Region: DUF4040; pfam13244 1310161000700 Domain of unknown function (DUF4040); Region: DUF4040; cl00676 1310161000701 Predicted membrane protein [Function unknown]; Region: COG1511 1310161000702 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 1310161000703 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1310161000704 active site 1310161000705 phosphorylation site [posttranslational modification] 1310161000706 intermolecular recognition site; other site 1310161000707 dimerization interface [polypeptide binding]; other site 1310161000708 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 1310161000709 DNA binding site [nucleotide binding] 1310161000710 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 1310161000711 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 1310161000712 dimerization interface [polypeptide binding]; other site 1310161000713 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 1310161000714 dimer interface [polypeptide binding]; other site 1310161000715 phosphorylation site [posttranslational modification] 1310161000716 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1310161000717 ATP binding site [chemical binding]; other site 1310161000718 Mg2+ binding site [ion binding]; other site 1310161000719 G-X-G motif; other site 1310161000720 Uncharacterized membrane-associated protein [Function unknown]; Region: DedA; COG0586 1310161000721 SNARE associated Golgi protein; Region: SNARE_assoc; pfam09335 1310161000722 Bacillus subtilis YkuE and related proteins, C-terminal metallophosphatase domain; Region: MPP_YkuE_C; cd07385 1310161000723 Calcineurin-like phosphoesterase; Region: Metallophos; pfam00149 1310161000724 putative active site [active] 1310161000725 putative metal binding site [ion binding]; other site 1310161000726 Yqey-like protein; Region: YqeY; pfam09424 1310161000727 Transglycosylase; Region: Transgly; pfam00912 1310161000728 penicillin-binding protein, 1A family; Region: PBP_1a_fam; TIGR02074 1310161000729 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; cl17760 1310161000730 PASTA domain of bacterial serine/threonine kinase pknB-like proteins. PknB is a member of a group of related transmembrane sensor kinases present in many gram positive bacteria, which has been shown to regulate cell shape in Mycobacterium tubercolosis; Region: PASTA_pknB; cd06577 1310161000731 Transcription factor WhiB; Region: Whib; pfam02467 1310161000732 Domain of unknown function (DUF4177); Region: DUF4177; pfam13783 1310161000733 This group of proteins belong to a large family of YjgF/YER057c/UK114-like proteins present in bacteria, archaea, and eukaryotes with no definitive function. The conserved domain is similar in structure to chorismate mutase but there is no sequence...; Region: YjgF_YER057c_UK114_like_1; cd02199 1310161000734 homotrimer interaction site [polypeptide binding]; other site 1310161000735 putative active site [active] 1310161000736 metabolite-proton symporter; Region: 2A0106; TIGR00883 1310161000737 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1310161000738 putative substrate translocation pore; other site 1310161000739 long-chain-fatty-acid--CoA ligase; Validated; Region: PRK06187 1310161000740 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 1310161000741 Bacterial Bile acid CoA ligases and similar proteins; Region: BACL_like; cd05929 1310161000742 acyl-activating enzyme (AAE) consensus motif; other site 1310161000743 acyl-activating enzyme (AAE) consensus motif; other site 1310161000744 putative AMP binding site [chemical binding]; other site 1310161000745 putative active site [active] 1310161000746 putative CoA binding site [chemical binding]; other site 1310161000747 helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347 1310161000748 Winged helix DNA-binding domain; Region: HTH_27; pfam13463 1310161000749 3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05557 1310161000750 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 1310161000751 NAD(P) binding site [chemical binding]; other site 1310161000752 active site 1310161000753 Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cd01292 1310161000754 active site 1310161000755 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 1310161000756 acyl-coenzyme A oxidase; Region: PLN02526 1310161000757 active site 1310161000758 NodN (nodulation factor N) contains a single hot dog fold similar to those of the peroxisomal Hydratase-Dehydrogenase-Epimerase (HDE) protein, and the fatty acid synthase beta subunit. Rhizobium and related species form nodules on the roots of their...; Region: NodN; cd03450 1310161000759 putative active site [active] 1310161000760 putative catalytic site [active] 1310161000761 cAMP-binding proteins - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases [Signal transduction mechanisms]; Region: Crp; COG0664 1310161000762 effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038 1310161000763 ligand binding site [chemical binding]; other site 1310161000764 flexible hinge region; other site 1310161000765 helix_turn_helix, cAMP Regulatory protein C-terminus; DNA binding domain of prokaryotic regulatory proteins belonging to the catabolite activator protein family; Region: HTH_CRP; cd00092 1310161000766 putative switch regulator; other site 1310161000767 non-specific DNA interactions [nucleotide binding]; other site 1310161000768 DNA binding site [nucleotide binding] 1310161000769 sequence specific DNA binding site [nucleotide binding]; other site 1310161000770 putative cAMP binding site [chemical binding]; other site 1310161000771 Predicted EndoIII-related endonuclease [DNA replication, recombination, and repair]; Region: Nth; COG0177 1310161000772 endonuclease III; includes endonuclease III (DNA-(apurinic or apyrimidinic site) lyase), alkylbase DNA glycosidases (Alka-family) and other DNA glycosidases; Region: ENDO3c; cd00056 1310161000773 minor groove reading motif; other site 1310161000774 helix-hairpin-helix signature motif; other site 1310161000775 substrate binding pocket [chemical binding]; other site 1310161000776 active site 1310161000777 TlpA-like family; composed of TlpA, ResA, DsbE and similar proteins. TlpA, ResA and DsbE are bacterial protein disulfide reductases with important roles in cytochrome maturation. They are membrane-anchored proteins with a soluble TRX domain containing a...; Region: TlpA_like_family; cd02966 1310161000778 Thioredoxin-like; Region: Thioredoxin_8; pfam13905 1310161000779 catalytic residues [active] 1310161000780 Coenzyme A pyrophosphatase (CoAse), a member of the Nudix hydrolase superfamily, functions to catalyze the elimination of oxidized inactive CoA, which can inhibit CoA-utilizing enzymes. The need of CoAses mainly arises under conditions of oxidative...; Region: CoAse; cd03426 1310161000781 putative active site [active] 1310161000782 putative CoA binding site [chemical binding]; other site 1310161000783 nudix motif; other site 1310161000784 metal binding site [ion binding]; metal-binding site 1310161000785 Colicin V production protein; Region: Colicin_V; pfam02674 1310161000786 Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain [Posttranslational modification, protein turnover, chaperones]; Region: DegQ; COG0265 1310161000787 Trypsin-like peptidase domain; Region: Trypsin_2; pfam13365 1310161000788 active site 1310161000789 substrate binding sites [chemical binding]; other site 1310161000790 Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596 1310161000791 Putative lysophospholipase; Region: Hydrolase_4; pfam12146 1310161000792 Protein of unknown function (DUF1469); Region: DUF1469; pfam07332 1310161000793 Phosphoserine phosphatase [Amino acid transport and metabolism]; Region: SerB; COG0560 1310161000794 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 1310161000795 motif II; other site 1310161000796 helicase/secretion neighborhood CpaE-like protein; Region: CpaE_hom_Actino; TIGR03815 1310161000797 Flp pilus assembly protein, ATPase CpaF [Intracellular trafficking and secretion]; Region: CpaF; COG4962 1310161000798 Type IV secretory pathway component VirB11, and related ATPases. The homohexamer, VirB11 is one of eleven Vir proteins, which are required for T-pilus biogenesis and virulence in the transfer of T-DNA from the Ti (tumor-inducing) plasmid of bacterial to...; Region: VirB11-like_ATPase; cd01130 1310161000799 ATP binding site [chemical binding]; other site 1310161000800 Walker A motif; other site 1310161000801 hexamer interface [polypeptide binding]; other site 1310161000802 Walker B motif; other site 1310161000803 Flp pilus assembly protein TadB [Intracellular trafficking and secretion]; Region: TadB; COG4965 1310161000804 Type II secretion system (T2SS), protein F; Region: T2SF; pfam00482 1310161000805 Flp pilus assembly protein TadC [Cell motility and secretion / Intracellular trafficking and secretion]; Region: TadC; COG2064 1310161000806 Type II secretion system (T2SS), protein F; Region: T2SF; pfam00482 1310161000807 Protein of unknown function (DUF4244); Region: DUF4244; pfam14029 1310161000808 helicase/secretion neighborhood putative DEAH-box helicase; Region: DECH_helic; TIGR03817 1310161000809 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 1310161000810 ATP binding site [chemical binding]; other site 1310161000811 putative Mg++ binding site [ion binding]; other site 1310161000812 Domain of unknown function (DUF1998); Region: DUF1998; pfam09369 1310161000813 Cold-Shock Protein (CSP) contains an S1-like cold-shock domain (CSD) that is found in eukaryotes, prokaryotes, and archaea. CSP's include the major cold-shock proteins CspA and CspB in bacteria and the eukaryotic gene regulatory factor Y-box...; Region: CSP_CDS; cd04458 1310161000814 DNA-binding site [nucleotide binding]; DNA binding site 1310161000815 RNA-binding motif; other site 1310161000816 DNA topoisomerase I subunit omega; Validated; Region: PRK07561 1310161000817 TOPRIM_TopoIA_TopoI: The topoisomerase-primase (TORPIM) domain found in members of the type IA family of DNA topoisomerases (Topo IA) similar to Escherichia coli DNA topoisomerase I. Type IA DNA topoisomerases remove (relax) negative supercoils in the...; Region: TOPRIM_TopoIA_TopoI; cd03363 1310161000818 active site 1310161000819 interdomain interaction site; other site 1310161000820 putative metal-binding site [ion binding]; other site 1310161000821 nucleotide binding site [chemical binding]; other site 1310161000822 DNA Topoisomerase, subtype IA; DNA-binding, ATP-binding and catalytic domain of bacterial DNA topoisomerases I and III, and eukaryotic DNA topoisomerase III and eubacterial and archael reverse gyrases. Topoisomerases clevage single or double stranded DNA...; Region: TOP1Ac; cd00186 1310161000823 domain I; other site 1310161000824 DNA binding groove [nucleotide binding] 1310161000825 phosphate binding site [ion binding]; other site 1310161000826 domain II; other site 1310161000827 domain III; other site 1310161000828 nucleotide binding site [chemical binding]; other site 1310161000829 catalytic site [active] 1310161000830 domain IV; other site 1310161000831 Topoisomerase C-terminal repeat; Region: Toprim_C_rpt; pfam13368 1310161000832 Topoisomerase C-terminal repeat; Region: Toprim_C_rpt; pfam13368 1310161000833 YhhN-like protein; Region: YhhN; pfam07947 1310161000834 DNA polymerase III subunit delta'; Validated; Region: PRK07940 1310161000835 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cl17189 1310161000836 Walker A motif; other site 1310161000837 ATP binding site [chemical binding]; other site 1310161000838 Walker B motif; other site 1310161000839 arginine finger; other site 1310161000840 DNA polymerase III, delta subunit, C terminal; Region: DNApol3-delta_C; pfam09115 1310161000841 Uncharacterized phage-associated protein [Function unknown]; Region: GepA; COG3600 1310161000842 Adenylate kinase and related kinases [Nucleotide transport and metabolism]; Region: Adk; COG0563 1310161000843 AAA domain; Region: AAA_17; pfam13207 1310161000844 Pseudouridylate synthases, 23S RNA-specific [Translation, ribosomal structure and biogenesis]; Region: RluA; COG0564 1310161000845 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 1310161000846 RNA binding surface [nucleotide binding]; other site 1310161000847 Pseudouridine synthase, RsuA/RluD family; Region: PseudoU_synth_RluCD_like; cd02869 1310161000848 active site 1310161000851 S-(hydroxymethyl)mycothiol dehydrogenase; Region: mycoS_dep_FDH; TIGR03451 1310161000852 Class III alcohol dehydrogenase; Region: Zn_ADH_class_III; cd08279 1310161000853 NAD binding site [chemical binding]; other site 1310161000854 catalytic Zn binding site [ion binding]; other site 1310161000855 substrate binding site [chemical binding]; other site 1310161000856 structural Zn binding site [ion binding]; other site 1310161000857 Metallo-beta-lactamase superfamily; Region: Lactamase_B; smart00849 1310161000858 3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05653 1310161000859 classical (c) SDRs; Region: SDR_c; cd05233 1310161000860 NAD(P) binding site [chemical binding]; other site 1310161000861 active site 1310161000862 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1310161000863 Major Facilitator Superfamily; Region: MFS_1; pfam07690 1310161000864 putative substrate translocation pore; other site 1310161000865 Nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: WcaG; COG0451 1310161000866 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 1310161000867 NAD(P) binding site [chemical binding]; other site 1310161000868 active site 1310161000869 Uncharacterized conserved protein (DUF2304); Region: DUF2304; cl01034 1310161000870 DPM_DPG-synthase_like is a member of the Glycosyltransferase 2 superfamily; Region: DPM_DPG-synthase_like; cd04179 1310161000871 Glycosyltransferases involved in cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WcaA; COG0463 1310161000872 Ligand binding site; other site 1310161000873 Putative Catalytic site; other site 1310161000874 DXD motif; other site 1310161000875 Ribonuclease HI [DNA replication, recombination, and repair]; Region: RnhA; COG0328 1310161000876 RNA/DNA hybrid binding site [nucleotide binding]; other site 1310161000877 active site 1310161000878 Predicted glycosyltransferases [General function prediction only]; Region: COG1216 1310161000879 Subfamily of Glycosyltransferase Family GT2 of unknown function; Region: GT_2_like_c; cd04186 1310161000880 Probable Catalytic site; other site 1310161000881 metal-binding site 1310161000882 5'-nucleotidase/2',3'-cyclic phosphodiesterase and related esterases [Nucleotide transport and metabolism]; Region: UshA; COG0737 1310161000883 Bacillus subtilis YhcR endonuclease and related proteins, N-terminal metallophosphatase domain; Region: MPP_YhcR_N; cd07412 1310161000884 putative active site [active] 1310161000885 putative metal binding site [ion binding]; other site 1310161000886 5'-nucleotidase, C-terminal domain; Region: 5_nucleotid_C; pfam02872 1310161000887 Zn-dependent alcohol dehydrogenases [General function prediction only]; Region: AdhP; COG1064 1310161000888 Cinnamyl alcohol dehydrogenases (CAD); Region: CAD1; cd05283 1310161000889 putative NAD(P) binding site [chemical binding]; other site 1310161000890 putative substrate binding site [chemical binding]; other site 1310161000891 catalytic Zn binding site [ion binding]; other site 1310161000892 structural Zn binding site [ion binding]; other site 1310161000893 dimer interface [polypeptide binding]; other site 1310161000894 G1P_TT_short is the short form of glucose-1-phosphate thymidylyltransferase; Region: G1P_TT_short; cd02538 1310161000895 glucose-1-phosphate thymidylyltransferase, short form; Region: rmlA; TIGR01207 1310161000896 substrate binding site; other site 1310161000897 tetramer interface; other site 1310161000898 dTDP-4-dehydrorhamnose 3,5-epimerase and related enzymes [Cell envelope biogenesis, outer membrane]; Region: RfbC; COG1898 1310161000899 dTDP-4-dehydrorhamnose reductase [Cell envelope biogenesis, outer membrane]; Region: RfbD; COG1091 1310161000900 dTDP-6-deoxy-L-lyxo-4-hexulose reductase and related proteins, extended (e) SDRs; Region: dTDP_HR_like_SDR_e; cd05254 1310161000901 NADP binding site [chemical binding]; other site 1310161000902 active site 1310161000903 putative substrate binding site [chemical binding]; other site 1310161000904 dTDP-D-glucose 4,6-dehydratase, extended (e) SDRs; Region: dTDP_GD_SDR_e; cd05246 1310161000905 dTDP-D-glucose 4,6-dehydratase [Cell envelope biogenesis, outer membrane]; Region: RfbB; COG1088 1310161000906 NAD binding site [chemical binding]; other site 1310161000907 substrate binding site [chemical binding]; other site 1310161000908 homodimer interface [polypeptide binding]; other site 1310161000909 active site 1310161000910 NADPH_oxidase. Nitroreductase family containing NADH oxidase and other, uncharacterized proteins that are similar to nitroreductase. Nitroreductase catalyzes the reduction of nitroaromatic compounds such as nitrotoluenes, nitrofurans and nitroimidazoles; Region: NADH_oxidase; cd03370 1310161000911 dimer interface [polypeptide binding]; other site 1310161000912 FMN binding site [chemical binding]; other site 1310161000913 Fe3+-siderophore binding domain FhuD. These proteins have been shown to function as initial receptors in ABC transport of Fe3+-siderophores in many eubacterial species. They belong to the TroA-like superfamily of helical backbone metal receptor proteins...; Region: FhuD; cd01146 1310161000914 Periplasmic binding protein; Region: Peripla_BP_2; pfam01497 1310161000915 siderophore binding site; other site 1310161000916 Protein of unknown function (DUF4230); Region: DUF4230; pfam14014 1310161000917 Aminopeptidase N [Amino acid transport and metabolism]; Region: PepN; COG0308 1310161000918 Peptidase M1 family Aminopeptidase N; Region: M1_APN_4; cd09603 1310161000919 Zn binding site [ion binding]; other site 1310161000920 Serine proteases of the peptidase family S9A [Amino acid transport and metabolism]; Region: COG1505 1310161000921 Prolyl oligopeptidase family; Region: Peptidase_S9; pfam00326 1310161000922 Bacterial protein of unknown function (DUF939); Region: DUF939; pfam06081 1310161000923 Predicted esterase [General function prediction only]; Region: COG0627 1310161000924 Capsular polysaccharide biosynthesis protein [Cell envelope biogenesis, outer membrane]; Region: COG3944 1310161000925 Chain length determinant protein; Region: Wzz; cl15801 1310161000926 capsular exopolysaccharide family; Region: eps_fam; TIGR01007 1310161000927 The Fer4_NifH superfamily contains a variety of proteins which share a common ATP-binding domain. Functionally, proteins in this superfamily use the energy from hydrolysis of NTP to transfer electron or ion; Region: Fer4_NifH; cl17203 1310161000928 Low molecular weight phosphatase family; Region: LMWPc; cl00105 1310161000929 Protein-tyrosine-phosphatase [Signal transduction mechanisms]; Region: Wzb; COG0394 1310161000930 active site 1310161000931 VPS10 domain; Region: VPS10; smart00602 1310161000932 Predicted nucleoside-diphosphate sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: COG1086 1310161000933 Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408 1310161000934 UDP-Glcnac (UDP-linked N-acetylglucosamine) inverting 4,6-dehydratase, extended (e) SDRs; Region: UDP_invert_4-6DH_SDR_e; cd05237 1310161000935 NAD(P) binding site [chemical binding]; other site 1310161000936 homodimer interface [polypeptide binding]; other site 1310161000937 substrate binding site [chemical binding]; other site 1310161000938 active site 1310161000939 aminotransferase, LLPSF_NHT_00031 family; Region: NHT_00031; TIGR04181 1310161000940 3-amino-5-hydroxybenzoic acid synthase family (AHBA_syn). AHBA_syn family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The members of this CD are involved in various biosynthetic pathways for secondary...; Region: AHBA_syn; cd00616 1310161000941 inhibitor-cofactor binding pocket; inhibition site 1310161000942 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1310161000943 catalytic residue [active] 1310161000944 Bacterial sugar transferase; Region: Bac_transf; pfam02397 1310161000945 colanic acid exporter; Provisional; Region: PRK10459 1310161000946 Uncharacterized subfamily of the multidrug and toxic compound extrusion (MATE) proteins; Region: MATE_tuaB_like; cd13127 1310161000947 UDP-N-acetylglucosamine 1-carboxyvinyltransferase; Region: murA; TIGR01072 1310161000948 UDP-N-acetylglucosamine enolpyruvyl transferase catalyzes enolpyruvyl transfer as part of the first step in the biosynthesis of peptidoglycan, a component of the bacterial cell wall. The reaction is phosphoenolpyruvate + UDP-N-acetyl-D-glucosamine =...; Region: UdpNAET; cd01555 1310161000949 hinge; other site 1310161000950 active site 1310161000951 UDP-N-acetylmuramate dehydrogenase [Cell envelope biogenesis, outer membrane]; Region: MurB; COG0812 1310161000952 FAD binding domain; Region: FAD_binding_4; pfam01565 1310161000953 UDP-N-acetylenolpyruvoylglucosamine reductase, C-terminal domain; Region: MurB_C; pfam02873 1310161000954 Glycosyltransferase like family 2; Region: Glyco_tranf_2_3; pfam13641 1310161000955 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394 1310161000956 active site 1310161000960 Predicted acyltransferases [Lipid metabolism]; Region: COG1835 1310161000961 Predicted acyltransferases [Lipid metabolism]; Region: COG1835 1310161000962 UDP-glucose 6-dehydrogenase; Provisional; Region: PRK15057 1310161000963 NAD-dependent glycerol-3-phosphate dehydrogenase N-terminus; Region: NAD_Gly3P_dh_N; pfam01210 1310161000964 UDP-glucose/GDP-mannose dehydrogenase family, central domain; Region: UDPG_MGDP_dh; pfam00984 1310161000965 UDP binding domain; Region: UDPG_MGDP_dh_C; smart00984 1310161000966 O-Antigen ligase; Region: Wzy_C; pfam04932 1310161000967 Glycosyltransferases involved in cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WcaA; COG0463 1310161000968 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394 1310161000969 active site 1310161000970 Putative Acyltransferase (AT), Left-handed parallel beta-Helix (LbH) domain; This group is composed of mostly uncharacterized proteins containing an N-terminal helical subdomain followed by a LbH domain. The alignment contains 6 turns, each containing...; Region: LbH_AT_putative; cd03360 1310161000971 sugar O-acyltransferase, sialic acid O-acetyltransferase NeuD family; Region: NeuD_NnaD; TIGR03570 1310161000972 putative trimer interface [polypeptide binding]; other site 1310161000973 putative CoA binding site [chemical binding]; other site 1310161000974 dihydrolipoamide dehydrogenase; Reviewed; Region: PRK07818 1310161000975 putative FAD-binding dehydrogenase; Reviewed; Region: PRK12834 1310161000976 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 1310161000977 Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain; Region: Pyr_redox_dim; pfam02852 1310161000978 Prokaryotic UGPase catalyses the synthesis of UDP-glucose; Region: UGPase_prokaryotic; cd02541 1310161000979 dTDP-glucose pyrophosphorylase [Cell envelope biogenesis, outer membrane]; Region: RfbA; COG1209 1310161000980 active site 1310161000981 tetramer interface; other site 1310161000982 This CD includes cysteinyl-tRNA(Pro) deacylases from Haemophilus influenzae and Escherichia coli and other related bacterial proteins. These trans-acting, single-domain proteins are homologs of ProX and also the cis-acting prolyl-tRNA synthetase (ProRS)...; Region: YbaK_deacylase; cd00002 1310161000983 putative deacylase active site [active] 1310161000984 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 1310161000985 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 1310161000986 non-specific DNA binding site [nucleotide binding]; other site 1310161000987 salt bridge; other site 1310161000988 sequence-specific DNA binding site [nucleotide binding]; other site 1310161000989 Predicted transcriptional regulator [General function prediction only]; Region: COG3800 1310161000990 Domain of unknown function (DUF955); Region: DUF955; pfam06114 1310161000991 Predicted transcriptional regulator (DUF2083); Region: DUF2083; pfam09856 1310161000992 Succinate:quinone oxidoreductase (SQR)-like Type B subfamily 2, transmembrane subunit; composed of proteins with similarity to the SQRs of Geobacter metallireducens and Corynebacterium glutamicum. SQR catalyzes the oxidation of succinate to fumarate...; Region: SQR_TypeB_2_TM; cd03498 1310161000993 succinate dehydrogenase (or fumarate reductase) cytochrome b subunit, b558 family; Region: sdhC_b558_fam; TIGR02046 1310161000994 putative Iron-sulfur protein interface [polypeptide binding]; other site 1310161000995 proximal heme binding site [chemical binding]; other site 1310161000996 distal heme binding site [chemical binding]; other site 1310161000997 putative dimer interface [polypeptide binding]; other site 1310161000998 succinate dehydrogenase flavoprotein subunit; Reviewed; Region: sdhA; PRK07573 1310161000999 L-aspartate oxidase; Provisional; Region: PRK06175 1310161001000 Fumarate reductase flavoprotein C-term; Region: Succ_DH_flav_C; pfam02910 1310161001001 succinate dehydrogenase/fumarate reductase iron-sulfur subunit; Validated; Region: PRK07570 1310161001002 2Fe-2S iron-sulfur cluster binding domain; Region: Fer2_3; pfam13085 1310161001003 Protein of unknown function (DUF1006); Region: DUF1006; pfam06224 1310161001004 DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213 1310161001005 Predicted membrane protein [Function unknown]; Region: COG2733 1310161001006 Protein of unknown function (DUF2516); Region: DUF2516; pfam10724 1310161001007 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 1310161001008 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 1310161001009 Major Facilitator Superfamily; Region: MFS_1; pfam07690 1310161001010 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1310161001011 putative substrate translocation pore; other site 1310161001012 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1310161001013 putative substrate translocation pore; other site 1310161001014 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1310161001015 Major Facilitator Superfamily; Region: MFS_1; pfam07690 1310161001016 putative substrate translocation pore; other site 1310161001017 formyltetrahydrofolate deformylase; Reviewed; Region: purU; PRK06027 1310161001018 N-terminal ACT domain of formyltetrahydrofolate deformylase (F4HF-DF; formyltetrahydrofolate hydrolase); Region: ACT_F4HF-DF; cd04875 1310161001019 Formyltetrahydrofolate deformylase (Formyl-FH4 hydrolase), C-terminal hydrolase domain; Region: FMT_core_Formyl-FH4-Hydrolase_C; cd08648 1310161001020 putative active site [active] 1310161001021 putative substrate binding site [chemical binding]; other site 1310161001022 putative cosubstrate binding site; other site 1310161001023 catalytic site [active] 1310161001024 2-deoxyribose-5-phosphate aldolase (DERA) of the DeoC family; Region: DeoC; cd00959 1310161001025 intersubunit interface [polypeptide binding]; other site 1310161001026 active site 1310161001027 catalytic residue [active] 1310161001028 Transcriptional regulators CsoR (copper-sensitive operon repressor), RcnR, and FrmR, and related domains; this domain superfamily was previously known as DUF156; Region: CsoR-like_DUF156; cd10148 1310161001029 putative homodimer interface [polypeptide binding]; other site 1310161001030 putative homotetramer interface [polypeptide binding]; other site 1310161001031 putative allosteric switch controlling residues; other site 1310161001032 putative metal binding site [ion binding]; other site 1310161001033 putative homodimer-homodimer interface [polypeptide binding]; other site 1310161001034 Cation transport ATPase [Inorganic ion transport and metabolism]; Region: ZntA; COG2217 1310161001035 Heavy-metal-associated domain (HMA) is a conserved domain of approximately 30 amino acid residues found in a number of proteins that transport or detoxify heavy metals, for example, the CPx-type heavy metal ATPases and copper chaperones. HMA domain...; Region: HMA; cd00371 1310161001036 metal-binding site [ion binding] 1310161001037 E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122 1310161001038 haloacid dehalogenase-like hydrolase; Region: HAD; cl17202 1310161001039 Htaa; Region: HtaA; pfam04213 1310161001040 Htaa; Region: HtaA; pfam04213 1310161001041 ABC-type hemin transport system, periplasmic component [Inorganic ion transport and metabolism]; Region: ChuT; COG4558 1310161001042 Helical backbone metal receptor (TroA-like domain). These proteins have been shown to function in the ABC transport of ferric siderophores and metal ions such as Mn2+, Fe3+, Cu2+ and/or Zn2+. Their ligand binding site is formed in the interface between...; Region: TroA-like; cl00262 1310161001043 intersubunit interface [polypeptide binding]; other site 1310161001044 ABC-type enterobactin transport system, permease component [Inorganic ion transport and metabolism]; Region: FepG; COG4779 1310161001045 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550 1310161001046 dimer interface [polypeptide binding]; other site 1310161001047 putative PBP binding regions; other site 1310161001048 ABC-ATPase subunit interface; other site 1310161001049 ABC-type hemin transport system, ATPase component [Inorganic ion transport and metabolism]; Region: COG4559 1310161001050 ATP-binding component of iron-siderophores, vitamin B12 and hemin transporters and related proteins; Region: ABC_Iron-Siderophores_B12_Hemin; cd03214 1310161001051 Walker A/P-loop; other site 1310161001052 ATP binding site [chemical binding]; other site 1310161001053 Q-loop/lid; other site 1310161001054 ABC transporter signature motif; other site 1310161001055 Walker B; other site 1310161001056 D-loop; other site 1310161001057 H-loop/switch region; other site 1310161001058 Htaa; Region: HtaA; pfam04213 1310161001059 Htaa; Region: HtaA; pfam04213 1310161001060 Protein of unknown function (DUF2505); Region: DUF2505; pfam10698 1310161001061 UDP-N-acetylenolpyruvoylglucosamine reductase; Provisional; Region: murB; PRK13903 1310161001062 FAD binding domain; Region: FAD_binding_4; pfam01565 1310161001063 UDP-N-acetylenolpyruvoylglucosamine reductase, C-terminal domain; Region: MurB_C; pfam02873 1310161001064 hypothetical protein; Provisional; Region: PRK07758 1310161001065 Domain of unknown function (DU1801); Region: DUF1801; pfam08818 1310161001066 long-chain-fatty-acid--CoA ligase; Validated; Region: PRK05605 1310161001067 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 1310161001068 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 1310161001069 acyl-activating enzyme (AAE) consensus motif; other site 1310161001070 AMP binding site [chemical binding]; other site 1310161001071 active site 1310161001072 CoA binding site [chemical binding]; other site 1310161001073 This family is most closely related to the GT1 family of glycosyltransferases. The sucrose-phosphate synthases in this family may be unique to plants and photosynthetic bacteria. This enzyme catalyzes the synthesis of sucrose 6-phosphate from fructose...; Region: GT1_Sucrose_synthase; cd03800 1310161001074 D-inositol-3-phosphate glycosyltransferase; Region: mycothiol_MshA; TIGR03449 1310161001075 putative ADP-binding pocket [chemical binding]; other site 1310161001076 Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067 1310161001077 catalytic core [active] 1310161001078 Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067 1310161001079 phosphate regulon sensor kinase PhoR; Region: phoR_proteo; TIGR02966 1310161001080 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 1310161001081 dimer interface [polypeptide binding]; other site 1310161001082 phosphorylation site [posttranslational modification] 1310161001083 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1310161001084 ATP binding site [chemical binding]; other site 1310161001085 Mg2+ binding site [ion binding]; other site 1310161001086 G-X-G motif; other site 1310161001087 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 1310161001088 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1310161001089 active site 1310161001090 phosphorylation site [posttranslational modification] 1310161001091 intermolecular recognition site; other site 1310161001092 dimerization interface [polypeptide binding]; other site 1310161001093 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 1310161001094 DNA binding site [nucleotide binding] 1310161001095 MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704 1310161001096 FtsX-like permease family; Region: FtsX; pfam02687 1310161001097 MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704 1310161001098 ABC-type antimicrobial peptide transport system, permease component [Defense mechanisms]; Region: SalY; COG0577 1310161001099 FtsX-like permease family; Region: FtsX; pfam02687 1310161001100 exopolyphosphatase; Region: exo_poly_only; TIGR03706 1310161001101 Ppx/GppA phosphatase family; Region: Ppx-GppA; pfam02541 1310161001102 pyrroline-5-carboxylate reductase; Reviewed; Region: PRK11880 1310161001103 NADP oxidoreductase coenzyme F420-dependent; Region: F420_oxidored; cl17232 1310161001104 DNA binding domain, excisionase family; Region: excise; TIGR01764 1310161001105 Phosphoserine phosphatase [Amino acid transport and metabolism]; Region: SerB; COG0560 1310161001106 HAD-superfamily subfamily IB hydrolase, TIGR01490; Region: HAD-SF-IB-hyp1 1310161001107 Glutaredoxin-like domain (DUF836); Region: DUF836; pfam05768 1310161001108 glutamyl-tRNA reductase; Reviewed; Region: hemA; PRK00045 1310161001109 NADP-binding domain of glutamyl-tRNA reductase; Region: NAD_bind_Glutamyl_tRNA_reduct; cd05213 1310161001110 tRNA; other site 1310161001111 putative tRNA binding site [nucleotide binding]; other site 1310161001112 putative NADP binding site [chemical binding]; other site 1310161001113 Glutamyl-tRNAGlu reductase, dimerisation domain; Region: GlutR_dimer; pfam00745 1310161001114 porphobilinogen deaminase; Reviewed; Region: hemC; PRK00072 1310161001115 Hydroxymethylbilane synthase (HMBS), also known as porphobilinogen deaminase (PBGD), is an intermediate enzyme in the biosynthetic pathway of tetrapyrrolic ring systems, such as heme, chlorophylls, and vitamin B12. HMBS catalyzes the conversion of...; Region: HMBS; cl17708 1310161001116 domain interfaces; other site 1310161001117 active site 1310161001118 Transcriptional regulator [Transcription]; Region: LysR; COG0583 1310161001119 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 1310161001120 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 1310161001121 dimerization interface [polypeptide binding]; other site 1310161001122 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1310161001123 metabolite-proton symporter; Region: 2A0106; TIGR00883 1310161001124 putative substrate translocation pore; other site 1310161001125 Sugar phosphate isomerases/epimerases [Carbohydrate transport and metabolism]; Region: IolE; COG1082 1310161001126 AP endonuclease family 2; These endonucleases play a role in DNA repair. Cleave phosphodiester bonds at apurinic or apyrimidinic sites; the alignment also contains hexulose-6-phosphate isomerases, enzymes that catalyze the epimerization of...; Region: AP2Ec; cl12060 1310161001127 AP (apurinic/apyrimidinic) site pocket; other site 1310161001128 DNA interaction; other site 1310161001129 Metal-binding active site; metal-binding site 1310161001130 4-hydroxyphenylpyruvate dioxygenase and related hemolysins [Amino acid transport and metabolism / General function prediction only]; Region: COG3185 1310161001131 This domain superfamily is found in a variety of structurally related metalloproteins, including the type I extradiol dioxygenases, glyoxalase I and a group of antibiotic resistance proteins; Region: Glo_EDI_BRP_like; cl14632 1310161001132 active site 1310161001133 metal binding site [ion binding]; metal-binding site 1310161001134 C-terminal domain of 4-hydroxyphenylpyruvate dioxygenase (HppD) and hydroxymandelate Synthase (HmaS); Region: HPPD_C_like; cd07250 1310161001135 active site 1310161001136 Fe binding site [ion binding]; other site 1310161001137 Dehydroquinase (DHQase), type II. Dehydroquinase (or 3-dehydroquinate dehydratase) catalyzes the reversible dehydration of 3-dehydroquinate to form 3-dehydroshikimate. This reaction is part of two metabolic pathways: the biosynthetic shikimate pathway...; Region: DHQase_II; cd00466 1310161001138 Dehydroquinase class II; Region: DHquinase_II; pfam01220 1310161001139 active site 1310161001140 trimer interface [polypeptide binding]; other site 1310161001141 dimer interface [polypeptide binding]; other site 1310161001142 quinate/shikimate dehydrogenase; Provisional; Region: PRK14027 1310161001143 Shikimate dehydrogenase substrate binding domain; Region: Shikimate_dh_N; pfam08501 1310161001144 NAD(P) binding domain of Shikimate dehydrogenase; Region: NAD_bind_Shikimate_DH; cd01065 1310161001145 shikimate binding site; other site 1310161001146 NAD(P) binding site [chemical binding]; other site 1310161001147 Ribosomal protein L7/L12 [Translation, ribosomal structure and biogenesis]; Region: RplL; COG0222 1310161001148 L11 interface [polypeptide binding]; other site 1310161001149 putative EF-Tu interaction site [polypeptide binding]; other site 1310161001150 putative EF-G interaction site [polypeptide binding]; other site 1310161001151 ABC-type spermidine/putrescine transport systems, ATPase components [Amino acid transport and metabolism]; Region: PotA; COG3842 1310161001152 ATP-binding cassette domain of the carbohydrate and solute transporters-like; Region: ABC_Carb_Solutes_like; cd03259 1310161001153 Walker A/P-loop; other site 1310161001154 ATP binding site [chemical binding]; other site 1310161001155 Q-loop/lid; other site 1310161001156 ABC transporter signature motif; other site 1310161001157 Walker B; other site 1310161001158 D-loop; other site 1310161001159 H-loop/switch region; other site 1310161001160 ABC-type Fe3+ transport system, permease component [Inorganic ion transport and metabolism]; Region: ThiP; COG1178 1310161001161 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1310161001162 dimer interface [polypeptide binding]; other site 1310161001163 conserved gate region; other site 1310161001164 putative PBP binding loops; other site 1310161001165 ABC-ATPase subunit interface; other site 1310161001166 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cl00427 1310161001167 ABC-type Fe3+ transport system, periplasmic component [Inorganic ion transport and metabolism]; Region: AfuA; COG1840 1310161001168 Bacterial extracellular solute-binding protein; Region: SBP_bac_8; pfam13416 1310161001169 S-AdoMet dependent tetrapyrrole methylases; Region: TP_methylase; cd09815 1310161001170 active site 1310161001171 homodimer interface [polypeptide binding]; other site 1310161001172 SAM binding site [chemical binding]; other site 1310161001173 Uroporphyrinogen-III synthase [Coenzyme metabolism]; Region: HemD; COG1587 1310161001174 Uroporphyrinogen-III synthase (HemD) catalyzes the asymmetrical cyclization of tetrapyrrole (linear) to uroporphyrinogen-III, the fourth step in the biosynthesis of heme. This ubiquitous enzyme is present in eukaryotes, bacteria and archaea. Mutations in...; Region: HemD; cd06578 1310161001175 active site 1310161001176 Domain of unknown function (DUF3806); Region: DUF3806; pfam12713 1310161001177 Porphobilinogen synthase (PBGS), which is also called delta-aminolevulinic acid dehydratase (ALAD), catalyzes the condensation of two 5-aminolevulinic acid (ALA) molecules to form the pyrrole porphobilinogen (PBG), which is the second step in the...; Region: ALAD_PBGS; cd00384 1310161001178 dimer interface [polypeptide binding]; other site 1310161001179 active site 1310161001180 Schiff base residues; other site 1310161001181 Cation transport ATPase [Inorganic ion transport and metabolism]; Region: ZntA; COG2217 1310161001182 E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122 1310161001183 Uroporphyrinogen decarboxylase (URO-D) is a dimeric cytosolic enzyme that decarboxylates the four acetate side chains of uroporphyrinogen III (uro-III) to create coproporphyrinogen III, without requiring any prosthetic groups or cofactors. This reaction...; Region: URO-D; cd00717 1310161001184 substrate binding site [chemical binding]; other site 1310161001185 active site 1310161001186 protoporphyrinogen oxidase; Reviewed; Region: PRK11883 1310161001187 glutamate-1-semialdehyde aminotransferase; Provisional; Region: PRK00062 1310161001188 Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610 1310161001189 inhibitor-cofactor binding pocket; inhibition site 1310161001190 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1310161001191 catalytic residue [active] 1310161001192 Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067 1310161001193 catalytic core [active] 1310161001194 TlpA-like family; composed of TlpA, ResA, DsbE and similar proteins. TlpA, ResA and DsbE are bacterial protein disulfide reductases with important roles in cytochrome maturation. They are membrane-anchored proteins with a soluble TRX domain containing a...; Region: TlpA_like_family; cd02966 1310161001195 Thioredoxin-like; Region: Thioredoxin_8; pfam13905 1310161001196 catalytic residues [active] 1310161001197 Cytochrome c biogenesis protein [Posttranslational modification, protein turnover, chaperones]; Region: CcdA; COG0785 1310161001198 Cytochrome C biogenesis protein transmembrane region; Region: DsbD; cl15788 1310161001199 ResB protein required for cytochrome c biosynthesis [Posttranslational modification, protein turnover, chaperones]; Region: ResB; COG1333 1310161001200 ResB-like family; Region: ResB; pfam05140 1310161001201 cytochrome c-type biogenesis protein CcsB; Region: cytochr_II_ccsB; TIGR03144 1310161001202 A family including aminopeptidase P, aminopeptidase M, and prolidase. Also known as metallopeptidase family M24. This family of enzymes is able to cleave amido-, imido- and amidino-containing bonds. Members exibit relatively narrow substrate specificity...; Region: APP_MetAP; cd01066 1310161001203 active site 1310161001204 This group of proteins belong to a large family of YjgF/YER057c/UK114-like proteins present in bacteria, archaea, and eukaryotes with no definitive function. The conserved domain is similar in structure to chorismate mutase but there is no sequence...; Region: YjgF_YER057c_UK114_like_1; cd02199 1310161001205 homotrimer interaction site [polypeptide binding]; other site 1310161001206 putative active site [active] 1310161001207 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 1310161001208 putative DNA binding site [nucleotide binding]; other site 1310161001209 dimerization interface [polypeptide binding]; other site 1310161001210 putative Zn2+ binding site [ion binding]; other site 1310161001211 Protein of unknown function (DUF4229); Region: DUF4229; pfam14012 1310161001212 1,4-dihydroxy-2-naphthoate octaprenyltransferase; Validated; Region: PRK06080 1310161001213 UbiA prenyltransferase family; Region: UbiA; pfam01040 1310161001214 acetolactate synthase catalytic subunit; Validated; Region: PRK08327 1310161001215 O-succinylbenzoic acid--CoA ligase; Provisional; Region: PRK07824 1310161001216 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 1310161001217 acyl-activating enzyme (AAE) consensus motif; other site 1310161001218 AMP binding site [chemical binding]; other site 1310161001219 active site 1310161001220 CoA binding site [chemical binding]; other site 1310161001221 Predicted membrane protein [Function unknown]; Region: COG2259 1310161001222 NAD-dependent aldehyde dehydrogenases [Energy production and conversion]; Region: PutA; COG1012 1310161001223 Alpha-Ketoglutaric Semialdehyde Dehydrogenase; Region: ALDH_KGSADH; cd07129 1310161001224 dimer interface [polypeptide binding]; other site 1310161001225 NADP binding site [chemical binding]; other site 1310161001226 catalytic residues [active] 1310161001227 5-dehydro-4-deoxyglucarate dehydratase, also called 5-keto-4-deoxy-glucarate dehydratase (KDGDH); Region: KDGDH; cd00951 1310161001228 Dihydrodipicolinate synthase/N-acetylneuraminate lyase [Amino acid transport and metabolism / Cell envelope biogenesis, outer membrane]; Region: DapA; COG0329 1310161001229 putative active site [active] 1310161001230 catalytic residue [active] 1310161001231 Transcriptional regulator [Transcription]; Region: LysR; COG0583 1310161001232 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 1310161001233 The C-terminal substrate binding domain of an uncharacterized LysR-type transcriptional regulator similar to regulators involved in the catabolism of aromatic compounds, contains type 2 periplasmic binding fold; Region: PBP2_LTTR_aromatics_like_1; cd08447 1310161001234 putative dimerization interface [polypeptide binding]; other site 1310161001235 putative substrate binding pocket [chemical binding]; other site 1310161001236 Protein of unknown function (DUF3349); Region: DUF3349; pfam11829 1310161001237 Predicted metal-dependent hydrolase of the TIM-barrel fold [General function prediction only]; Region: COG3618 1310161001238 Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281 1310161001239 active site 1310161001240 The hotdog fold was initially identified in the E. coli FabA (beta-hydroxydecanoyl-acyl carrier protein (ACP)-dehydratase) structure and subsequently in 4HBT (4-hydroxybenzoyl-CoA thioesterase) from Pseudomonas. A number of other seemingly unrelated...; Region: hot_dog; cd03440 1310161001241 active site 1 [active] 1310161001242 active site 2 [active] 1310161001243 Phosphate/sulphate permeases [Inorganic ion transport and metabolism]; Region: PitA; COG0306 1310161001244 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 1310161001245 Enoyl-CoA hydratase/isomerase family; Region: ECH; pfam00378 1310161001246 substrate binding site [chemical binding]; other site 1310161001247 oxyanion hole (OAH) forming residues; other site 1310161001248 trimer interface [polypeptide binding]; other site 1310161001249 PCD_DCoH: The bifunctional protein pterin-4alpha-carbinolamine dehydratase (PCD), also known as DCoH (dimerization cofactor of hepatocyte nuclear factor-1), is both a transcription activator and a metabolic enzyme. DCoH stimulates gene expression by...; Region: PCD_DCoH; cd00488 1310161001250 aromatic arch; other site 1310161001251 DCoH dimer interaction site [polypeptide binding]; other site 1310161001252 DCoH /HNF-1 dimer interaction site [polypeptide binding]; other site 1310161001253 DCoH tetramer interaction site [polypeptide binding]; other site 1310161001254 substrate binding site [chemical binding]; other site 1310161001255 Type 1 glutamine amidotransferase (GATase1)-like domain found in peptidase E_like proteins; Region: GAT1_Peptidase_E_like; cd03129 1310161001256 catalytic triad [active] 1310161001257 active site nucleophile [active] 1310161001258 O-succinylbenzoate synthase; Provisional; Region: PRK02901 1310161001259 o-Succinylbenzoate synthase (OSBS) catalyzes the conversion of 2-succinyl-6-hydroxy-2,4-cyclohexadiene-1-carboxylate (SHCHC) to 4-(2'-carboxyphenyl)-4-oxobutyrate (o-succinylbenzoate or OSB), a reaction in the menaquinone biosynthetic pathway; Region: OSBS; cd03320 1310161001260 active site 1310161001261 2-succinyl-6-hydroxy-2, 4-cyclohexadiene-1-carboxylate synthase [Coenzyme metabolism]; Region: MenD; COG1165 1310161001262 Pyrimidine (PYR) binding domain of 2-succinyl-5-enolpyruvyl-6-hydroxy-3-cyclohexadiene-1- carboxylate synthase (MenD) and related proteins; Region: TPP_PYR_MenD; cd07037 1310161001263 dimer interface [polypeptide binding]; other site 1310161001264 tetramer interface [polypeptide binding]; other site 1310161001265 PYR/PP interface [polypeptide binding]; other site 1310161001266 TPP binding site [chemical binding]; other site 1310161001267 Thiamine pyrophosphate (TPP) family, SHCHC synthase subfamily, TPP-binding module; composed of proteins similar to Escherichia coli 2-succinyl-6-hydroxyl-2,4-cyclohexadiene-1-carboxylic acid (SHCHC) synthase (also called MenD). SHCHC synthase plays a key...; Region: TPP_SHCHC_synthase; cd02009 1310161001268 TPP-binding site; other site 1310161001269 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 1310161001270 This family is most closely related to the GT1 family of glycosyltransferases. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can...; Region: GT1_like_2; cd03814 1310161001271 D-alanine/D-serine/glycine permease; Provisional; Region: PRK11049 1310161001272 Methylase involved in ubiquinone/menaquinone biosynthesis [Coenzyme metabolism]; Region: UbiE; COG2226 1310161001273 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 1310161001274 S-adenosylmethionine binding site [chemical binding]; other site 1310161001275 Geranylgeranyl pyrophosphate synthase [Coenzyme metabolism]; Region: IspA; COG0142 1310161001276 Trans-Isoprenyl Diphosphate Synthases, head-to-tail; Region: Trans_IPPS_HT; cd00685 1310161001277 substrate binding pocket [chemical binding]; other site 1310161001278 chain length determination region; other site 1310161001279 substrate-Mg2+ binding site; other site 1310161001280 catalytic residues [active] 1310161001281 aspartate-rich region 1; other site 1310161001282 active site lid residues [active] 1310161001283 aspartate-rich region 2; other site 1310161001284 preprotein translocase subunit SecE; Reviewed; Region: secE; PRK07597 1310161001285 50S ribosomal protein L11; Validated; Region: rplK; PRK00140 1310161001286 Ribosomal protein L11. Ribosomal protein L11, together with proteins L10 and L7/L12, and 23S rRNA, form the L7/L12 stalk on the surface of the large subunit of the ribosome. The homologous eukaryotic cytoplasmic protein is also called 60S ribosomal...; Region: Ribosomal_L11; cd00349 1310161001287 23S rRNA interface [nucleotide binding]; other site 1310161001288 L7/L12 interface [polypeptide binding]; other site 1310161001289 putative thiostrepton binding site; other site 1310161001290 L25 interface [polypeptide binding]; other site 1310161001291 Ribosomal protein L1. The L1 protein, located near the E-site of the ribosome, forms part of the L1 stalk along with 23S rRNA. In bacteria and archaea, L1 functions both as a ribosomal protein that binds rRNA, and as a translation repressor that binds...; Region: Ribosomal_L1; cd00403 1310161001292 mRNA/rRNA interface [nucleotide binding]; other site 1310161001293 Regulator of polyketide synthase expression [Signal transduction mechanisms / Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG2508 1310161001294 PucR C-terminal helix-turn-helix domain; Region: HTH_30; pfam13556 1310161001295 4-aminobutyrate aminotransferase; Provisional; Region: PRK06058 1310161001296 Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610 1310161001297 inhibitor-cofactor binding pocket; inhibition site 1310161001298 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1310161001299 catalytic residue [active] 1310161001300 Aldehyde dehydrogenase family; Region: Aldedh; pfam00171 1310161001301 Mitochondrial succinate-semialdehyde dehydrogenase and ALDH family members 5A1 and 5F1-like; Region: ALDH_F5_SSADH_GabD; cd07103 1310161001302 tetramerization interface [polypeptide binding]; other site 1310161001303 NAD(P) binding site [chemical binding]; other site 1310161001304 catalytic residues [active] 1310161001305 Amino acid permeases [Amino acid transport and metabolism]; Region: SdaC; COG0814 1310161001306 Tryptophan/tyrosine permease family; Region: Trp_Tyr_perm; cl17316 1310161001307 Phytoene dehydrogenase and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG1233 1310161001308 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450 1310161001309 Protein of unknown function (DUF541); Region: SIMPL; pfam04402 1310161001310 Ribosomal protein L10 family, L10 subfamily; composed of bacterial 50S ribosomal protein and eukaryotic mitochondrial 39S ribosomal protein, L10. L10 occupies the L7/L12 stalk of the ribosome. The N-terminal domain (NTD) of L10 interacts with L11 protein...; Region: Ribosomal_L10; cd05797 1310161001311 23S rRNA interface [nucleotide binding]; other site 1310161001312 Interface with L7/L12 ribosomal proteins [polypeptide binding]; other site 1310161001313 Ribosomal protein L7/L12. Ribosomal protein L7/L12 refers to the large ribosomal subunit proteins L7 and L12, which are identical except that L7 is acetylated at the N terminus. It is a component of the L7/L12 stalk, which is located at the surface of...; Region: Ribosomal_L7_L12; cd00387 1310161001314 core dimer interface [polypeptide binding]; other site 1310161001315 peripheral dimer interface [polypeptide binding]; other site 1310161001316 L10 interface [polypeptide binding]; other site 1310161001317 L11 interface [polypeptide binding]; other site 1310161001318 putative EF-Tu interaction site [polypeptide binding]; other site 1310161001319 putative EF-G interaction site [polypeptide binding]; other site 1310161001320 Protein of unknown function (DUF3068); Region: DUF3068; pfam11271 1310161001321 Tetraspanin family; Region: Tetraspannin; pfam00335 1310161001322 DNA-directed RNA polymerase subunit beta; Reviewed; Region: rpoB; PRK00405 1310161001323 RNA polymerase beta subunit. RNA polymerases catalyse the DNA dependent polymerization of RNA. Prokaryotes contain a single RNA polymerase compared to three in eukaryotes (not including mitochondrial. and chloroplast polymerases). Each RNA polymerase...; Region: RNA_pol_B_RPB2; cl17585 1310161001324 RNA polymerase Rpb2, domain 2; Region: RNA_pol_Rpb2_2; pfam04561 1310161001325 RNA polymerase beta subunit. RNA polymerases catalyse the DNA dependent polymerization of RNA. Prokaryotes contain a single RNA polymerase compared to three in eukaryotes (not including mitochondrial. and chloroplast polymerases). Each RNA polymerase...; Region: RNA_pol_B_RPB2; cd00653 1310161001326 RPB1 interaction site [polypeptide binding]; other site 1310161001327 RPB10 interaction site [polypeptide binding]; other site 1310161001328 RPB11 interaction site [polypeptide binding]; other site 1310161001329 RPB3 interaction site [polypeptide binding]; other site 1310161001330 RPB12 interaction site [polypeptide binding]; other site 1310161001331 RNA polymerase Rpb1, domain 1; Region: RNA_pol_Rpb1_1; pfam04997 1310161001332 ligand binding domain of Tar- and Tsr-related chemoreceptors; Region: Tar_Tsr_LBD; cl00144 1310161001333 DNA-directed RNA polymerase subunit beta'; Provisional; Region: PRK00566 1310161001334 RNA polymerase I subunit A N-terminus; Region: RPOLA_N; smart00663 1310161001335 RNA polymerase Rpb1, domain 3; Region: RNA_pol_Rpb1_3; pfam04983 1310161001336 RNA polymerase Rpb1, domain 4; Region: RNA_pol_Rpb1_4; pfam05000 1310161001337 Largest subunit (beta') of Bacterial DNA-dependent RNA polymerase (RNAP), C-terminal domain; Region: RNAP_beta'_C; cd02655 1310161001338 Rpb1 (beta') - Rpb6 (omega) interaction site [polypeptide binding]; other site 1310161001339 G-loop; other site 1310161001340 Largest subunit (beta') of Bacterial DNA-dependent RNA polymerase (RNAP), C-terminal domain; Region: RNAP_beta'_C; cd02655 1310161001341 DNA binding site [nucleotide binding] 1310161001342 Rpb1 (beta') - Rpb2 (beta) interaction site [polypeptide binding]; other site 1310161001343 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 1310161001344 salt bridge; other site 1310161001345 non-specific DNA binding site [nucleotide binding]; other site 1310161001346 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 1310161001347 sequence-specific DNA binding site [nucleotide binding]; other site 1310161001348 Domain of unknown function (DUF1707); Region: DUF1707; pfam08044 1310161001349 S12-like family, 30S ribosomal protein S12 subfamily; S12 is located at the interface of the large and small ribosomal subunits of prokaryotes, chloroplasts and mitochondria, where it plays an important role in both tRNA and ribosomal subunit...; Region: Ribosomal_S12; cd03368 1310161001350 S17 interaction site [polypeptide binding]; other site 1310161001351 S8 interaction site; other site 1310161001352 16S rRNA interaction site [nucleotide binding]; other site 1310161001353 streptomycin interaction site [chemical binding]; other site 1310161001354 23S rRNA interaction site [nucleotide binding]; other site 1310161001355 aminoacyl-tRNA interaction site (A-site) [nucleotide binding]; other site 1310161001356 30S ribosomal protein S7; Validated; Region: PRK05302 1310161001357 elongation factor G; Reviewed; Region: PRK00007 1310161001358 Elongation factor G (EF-G) family involved in both the elongation and ribosome recycling phases of protein synthesis; Region: EF-G; cd01886 1310161001359 G1 box; other site 1310161001360 putative GEF interaction site [polypeptide binding]; other site 1310161001361 GTP/Mg2+ binding site [chemical binding]; other site 1310161001362 Switch I region; other site 1310161001363 G2 box; other site 1310161001364 G3 box; other site 1310161001365 Switch II region; other site 1310161001366 G4 box; other site 1310161001367 G5 box; other site 1310161001368 EFG_mtEFG_II: this subfamily represents the domain II of elongation factor G (EF-G) in bacteria and, the C-terminus of mitochondrial Elongation factor G1 (mtEFG1) and G2 (mtEFG2)_like proteins found in eukaryotes. During the process of peptide synthesis...; Region: EFG_mtEFG_II; cd04088 1310161001369 EFG_mtEFG1_IV: domains similar to domain IV of the bacterial translational elongation factor (EF) EF-G. Included in this group is a domain of mitochondrial Elongation factor G1 (mtEFG1) proteins homologous to domain IV of EF-G. Eukaryotic cells harbor 2...; Region: EFG_mtEFG1_IV; cd01434 1310161001370 EFG_mtEFG_C: domains similar to the C-terminal domain of the bacterial translational elongation factor (EF) EF-G. Included in this group is the C-terminus of mitochondrial Elongation factor G1 (mtEFG1) and G2 (mtEFG2) proteins. Eukaryotic cells harbor 2...; Region: EFG_mtEFG_C; cd03713 1310161001371 elongation factor Tu; Reviewed; Region: PRK00049 1310161001372 Elongation Factor Tu (EF-Tu) GTP-binding proteins; Region: EF_Tu; cd01884 1310161001373 G1 box; other site 1310161001374 GEF interaction site [polypeptide binding]; other site 1310161001375 GTP/Mg2+ binding site [chemical binding]; other site 1310161001376 Switch I region; other site 1310161001377 G2 box; other site 1310161001378 G3 box; other site 1310161001379 Switch II region; other site 1310161001380 G4 box; other site 1310161001381 G5 box; other site 1310161001382 EFTU_II: Elongation factor Tu domain II. Elongation factors Tu (EF-Tu) are three-domain GTPases with an essential function in the elongation phase of mRNA translation. The GTPase center of EF-Tu is in the N-terminal domain (domain I), also known as the...; Region: EFTU_II; cd03697 1310161001383 Domain III of elongation factor (EF) Tu. Ef-Tu consists of three structural domains, designated I, II and III. Domain III adopts a beta barrel structure. Domain III is involved in binding to both charged tRNA and binding to elongation factor Ts (EF-Ts); Region: EFTU_III; cd03707 1310161001384 Antibiotic Binding Site [chemical binding]; other site 1310161001385 ABC-type cobalamin/Fe3+-siderophores transport systems, ATPase components [Inorganic ion transport and metabolism / Coenzyme metabolism]; Region: FepC; COG1120 1310161001386 ATP-binding component of iron-siderophores, vitamin B12 and hemin transporters and related proteins; Region: ABC_Iron-Siderophores_B12_Hemin; cd03214 1310161001387 Walker A/P-loop; other site 1310161001388 ATP binding site [chemical binding]; other site 1310161001389 Q-loop/lid; other site 1310161001390 ABC transporter signature motif; other site 1310161001391 Walker B; other site 1310161001392 D-loop; other site 1310161001393 H-loop/switch region; other site 1310161001394 ABC-type enterobactin transport system, permease component [Inorganic ion transport and metabolism]; Region: FepG; COG4779 1310161001395 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550 1310161001396 ABC-ATPase subunit interface; other site 1310161001397 dimer interface [polypeptide binding]; other site 1310161001398 putative PBP binding regions; other site 1310161001399 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cl00462 1310161001400 ABC-type enterobactin transport system, permease component [Inorganic ion transport and metabolism]; Region: FepG; COG4779 1310161001401 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550 1310161001402 ABC-ATPase subunit interface; other site 1310161001403 dimer interface [polypeptide binding]; other site 1310161001404 putative PBP binding regions; other site 1310161001405 Acetyl-CoA hydrolase [Energy production and conversion]; Region: ACH1; COG0427 1310161001406 Acetyl-CoA hydrolase/transferase C-terminal domain; Region: AcetylCoA_hyd_C; pfam13336 1310161001407 30S ribosomal protein S10; Reviewed; Region: rpsJ; PRK00596 1310161001408 50S ribosomal protein L3; Validated; Region: rplC; PRK00001 1310161001409 50S ribosomal protein L4; Provisional; Region: rplD; PRK05319 1310161001410 50S ribosomal protein L23; Reviewed; Region: rplW; PRK05738 1310161001411 50S ribosomal protein L2; Validated; Region: rplB; PRK09374 1310161001412 Ribosomal Proteins L2, RNA binding domain; Region: Ribosomal_L2; pfam00181 1310161001413 Ribosomal Proteins L2, C-terminal domain; Region: Ribosomal_L2_C; pfam03947 1310161001414 30S ribosomal protein S19; Reviewed; Region: rpsS; PRK00357 1310161001415 Ribosomal protein L22/L17e. L22 (L17 in eukaryotes) is a core protein of the large ribosomal subunit. It is the only ribosomal protein that interacts with all six domains of 23S rRNA, and is one of the proteins important for directing the proper...; Region: Ribosomal_L22; cd00336 1310161001416 putative translocon binding site; other site 1310161001417 protein-rRNA interface [nucleotide binding]; other site 1310161001418 30S ribosomal protein S3; Reviewed; Region: rpsC; PRK00310 1310161001419 K homology RNA-binding (KH) domain of the prokaryotic 30S small ribosomal subunit protein S3. S3 is part of the head region of the 30S ribosomal subunit and is believed to interact with mRNA as it threads its way from the latch into the channel. The KH...; Region: 30S_S3_KH; cd02412 1310161001420 G-X-X-G motif; other site 1310161001421 Ribosomal protein S3, C-terminal domain; Region: Ribosomal_S3_C; pfam00189 1310161001422 Ribosomal_L16_L10e: L16 is an essential protein in the large ribosomal subunit of bacteria, mitochondria, and chloroplasts. Large subunits that lack L16 are defective in peptidyl transferase activity, peptidyl-tRNA hydrolysis activity, association with...; Region: Ribosomal_L16_L10e; cd01433 1310161001423 23S rRNA interface [nucleotide binding]; other site 1310161001424 5S rRNA interface [nucleotide binding]; other site 1310161001425 putative antibiotic binding site [chemical binding]; other site 1310161001426 L25 interface [polypeptide binding]; other site 1310161001427 L27 interface [polypeptide binding]; other site 1310161001428 Ribosomal L29 protein/HIP. L29 is a protein of the large ribosomal Subunit. A homolog, called heparin/heparan sulfate interacting protein (HIP), has also been identified in mammals. L29 is located on the surface of the large ribosomal subunit, where it...; Region: Ribosomal_L29_HIP; cd00427 1310161001429 putative translocon interaction site; other site 1310161001430 23S rRNA interface [nucleotide binding]; other site 1310161001431 signal recognition particle (SRP54) interaction site; other site 1310161001432 L23 interface [polypeptide binding]; other site 1310161001433 trigger factor interaction site; other site 1310161001434 30S ribosomal protein S17; Reviewed; Region: rpsQ; PRK05610 1310161001435 50S ribosomal protein L14; Validated; Region: rplN; PRK05483 1310161001436 50S ribosomal protein L24; Reviewed; Region: rplX; PRK00004 1310161001437 KOW motif of Ribosomal Protein L26; Region: KOW_RPL26; cd06089 1310161001438 RNA binding site [nucleotide binding]; other site 1310161001439 50S ribosomal protein L5; Validated; Region: rplE; PRK00010 1310161001440 Ribosomal protein L5; Region: Ribosomal_L5; pfam00281 1310161001441 ribosomal L5P family C-terminus; Region: Ribosomal_L5_C; pfam00673 1310161001443 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3464 1310161001444 Transposase; Region: DDE_Tnp_ISL3; pfam01610 1310161001446 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 1310161001447 Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248 1310161001448 active site 1310161001449 catalytic tetrad [active] 1310161001450 formate dehydrogenase accessory protein; Reviewed; Region: PRK00724 1310161001451 oxidoreductase alpha (molybdopterin) subunit; Region: Fdhalpha-like; TIGR01701 1310161001452 The MopB_ydeP CD includes a group of related uncharacterized bacterial molybdopterin-binding oxidoreductase-like domains with a putative molybdopterin cofactor binding site. These members belong to the molybdopterin_binding (MopB) superfamily of proteins; Region: MopB_ydeP; cd02767 1310161001453 putative molybdopterin cofactor binding site [chemical binding]; other site 1310161001454 The MopB_CT_ydeP CD includes a group of related uncharacterized bacterial molybdopterin-binding oxidoreductase-like domains with a putative molybdopterin cofactor binding site. This CD is of the conserved molybdopterin_binding C-terminal (MopB_CT) region...; Region: MopB_CT_ydeP; cd02787 1310161001455 putative molybdopterin cofactor binding site; other site 1310161001456 ABC-type cobalt transport system, ATPase component [Inorganic ion transport and metabolism]; Region: CbiO; COG1122 1310161001457 First domain of the ATP-binding cassette component of cobalt transport system; Region: ABC_cobalt_CbiO_domain1; cd03225 1310161001458 Walker A/P-loop; other site 1310161001459 ATP binding site [chemical binding]; other site 1310161001460 Q-loop/lid; other site 1310161001461 ABC transporter signature motif; other site 1310161001462 Walker B; other site 1310161001463 D-loop; other site 1310161001464 H-loop/switch region; other site 1310161001465 ABC-type cobalt transport system, ATPase component [Inorganic ion transport and metabolism]; Region: CbiO; COG1122 1310161001466 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 1310161001467 Walker A/P-loop; other site 1310161001468 ATP binding site [chemical binding]; other site 1310161001469 Q-loop/lid; other site 1310161001470 ABC transporter signature motif; other site 1310161001471 Walker B; other site 1310161001472 D-loop; other site 1310161001473 H-loop/switch region; other site 1310161001474 ABC-type cobalt transport system, permease component CbiQ and related transporters [Inorganic ion transport and metabolism]; Region: CbiQ; COG0619 1310161001475 This group contains class II terpene cyclases, protein prenyltransferases beta subunit, two broadly specific proteinase inhibitors alpha2-macroglobulin (alpha (2)-M) and pregnancy zone protein (PZP) and, the C3 C4 and C5 components of vertebrate...; Region: ISOPREN_C2_like; cd00688 1310161001476 Prenyltransferase-like; Region: Prenyltrans_2; pfam13249 1310161001477 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 1310161001478 Acetyltransferases, including N-acetylases of ribosomal proteins [Translation, ribosomal structure and biogenesis]; Region: RimL; COG1670 1310161001479 Coenzyme A binding pocket [chemical binding]; other site 1310161001480 30S ribosomal protein S8; Validated; Region: rpsH; PRK00136 1310161001481 50S ribosomal protein L6; Validated; Region: rplF; PRK05498 1310161001482 Ribosomal protein L6; Region: Ribosomal_L6; pfam00347 1310161001483 Ribosomal protein L6; Region: Ribosomal_L6; pfam00347 1310161001484 Ribosomal L18/L5e: L18 (L5e) is a ribosomal protein found in the central protuberance (CP) of the large subunit. L18 binds 5S rRNA and induces a conformational change that stimulates the binding of L5 to 5S rRNA. Association of 5S rRNA with 23S rRNA...; Region: Ribosomal_L18_L5e; cd00432 1310161001485 5S rRNA interface [nucleotide binding]; other site 1310161001486 L27 interface [polypeptide binding]; other site 1310161001487 23S rRNA interface [nucleotide binding]; other site 1310161001488 L5 interface [polypeptide binding]; other site 1310161001489 30S ribosomal protein S5; Validated; Region: rpsE; PRK00550 1310161001490 Ribosomal protein S5, N-terminal domain; Region: Ribosomal_S5; pfam00333 1310161001491 Ribosomal protein S5, C-terminal domain; Region: Ribosomal_S5_C; pfam03719 1310161001492 Ribosomal protein L30, which is found in eukaryotes and prokaryotes but not in archaea, is one of the smallest ribosomal proteins with a molecular mass of about 7kDa. L30 binds the 23SrRNA as well as the 5S rRNA and is one of five ribosomal proteins that...; Region: Ribosomal_L30; cd01658 1310161001493 23S rRNA binding site [nucleotide binding]; other site 1310161001494 50S ribosomal protein L15; Reviewed; Region: rplO; PRK05592 1310161001495 NAD(P)+-dependent aldehyde dehydrogenase superfamily; Region: ALDH-SF; cl11961 1310161001496 NAD(P)+-dependent aldehyde dehydrogenase superfamily; Region: ALDH-SF; cl11961 1310161001497 Aldehyde dehydrogenase family; Region: Aldedh; pfam00171 1310161001498 Rhodococcus ruber 6-oxolauric acid dehydrogenase-like and related proteins; Region: ALDH_CddD-AldA-like; cd07089 1310161001499 NAD binding site [chemical binding]; other site 1310161001500 catalytic residues [active] 1310161001501 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 1310161001502 Zn2+ binding site [ion binding]; other site 1310161001503 Mg2+ binding site [ion binding]; other site 1310161001504 phenylpropionate dioxygenase ferredoxin reductase subunit; Provisional; Region: PRK09754 1310161001505 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500 1310161001506 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 1310161001507 Ferredoxin [Energy production and conversion]; Region: Fdx; COG0633 1310161001508 2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207 1310161001509 catalytic loop [active] 1310161001510 iron binding site [ion binding]; other site 1310161001511 3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05557 1310161001512 classical (c) SDRs; Region: SDR_c; cd05233 1310161001513 NAD(P) binding site [chemical binding]; other site 1310161001514 active site 1310161001515 hypothetical protein; Provisional; Region: PRK08296 1310161001516 PEP-utilising enzyme, mobile domain; Region: PEP-utilizers; pfam00391 1310161001517 Pyruvate phosphate dikinase, PEP/pyruvate binding domain; Region: PPDK_N; pfam01326 1310161001518 Cytochrome P450 [Secondary metabolites biosynthesis, transport, and catabolism]; Region: CypX; COG2124 1310161001519 Cytochrome P450; Region: p450; cl12078 1310161001520 Transcriptional regulator [Transcription]; Region: IclR; COG1414 1310161001521 helix_turn_helix isocitrate lyase regulation; Region: HTH_ICLR; smart00346 1310161001522 Bacterial transcriptional regulator; Region: IclR; pfam01614 1310161001523 preprotein translocase subunit SecY; Reviewed; Region: secY; PRK09204 1310161001524 SecY translocase; Region: SecY; pfam00344 1310161001525 adenylate kinase; Reviewed; Region: adk; PRK00279 1310161001526 Adenylate kinase (ADK) catalyzes the reversible phosphoryl transfer from adenosine triphosphates (ATP) to adenosine monophosphates (AMP) and to yield adenosine diphosphates (ADP). This enzyme is required for the biosynthesis of ADP and is essential for...; Region: ADK; cd01428 1310161001527 AMP-binding site [chemical binding]; other site 1310161001528 ATP-AMP (Ap5A)-binding site [chemical binding]; other site 1310161001529 Methionine Aminopeptidase 1. E.C. 3.4.11.18. Also known as methionyl aminopeptidase and Peptidase M. Catalyzes release of N-terminal amino acids, preferentially methionine, from peptides and arylamides; Region: MetAP1; cd01086 1310161001530 active site 1310161001531 Uncharacterized protein conserved in bacteria [Function unknown]; Region: ErfK; COG1376 1310161001532 L,D-transpeptidase catalytic domain; Region: YkuD; pfam03734 1310161001533 S1_IF1: Translation Initiation Factor IF1, S1-like RNA-binding domain. IF1 contains an S1-like RNA-binding domain, which is found in a wide variety of RNA-associated proteins. Translation initiation includes a number of interrelated steps preceding the...; Region: S1_IF1; cd04451 1310161001534 rRNA binding site [nucleotide binding]; other site 1310161001535 predicted 30S ribosome binding site; other site 1310161001536 Ribosomal protein S13 [Translation, ribosomal structure and biogenesis]; Region: RpsM; COG0099 1310161001537 30S ribosomal protein S13; Region: bact_S13; TIGR03631 1310161001538 30S ribosomal protein S11; Validated; Region: PRK05309 1310161001539 DNA-directed RNA polymerase subunit alpha; Provisional; Region: PRK05182 1310161001540 N-terminal domain of the Alpha subunit of Bacterial RNA polymerase; Region: RNAP_alpha_NTD; cd06928 1310161001541 alphaNTD - beta interaction site [polypeptide binding]; other site 1310161001542 alphaNTD homodimer interface [polypeptide binding]; other site 1310161001543 alphaNTD - beta' interaction site [polypeptide binding]; other site 1310161001544 Bacterial RNA polymerase, alpha chain C terminal domain; Region: RNA_pol_A_CTD; pfam03118 1310161001545 50S ribosomal protein L17; Validated; Region: rplQ; PRK05591 1310161001546 tRNA pseudouridine synthase A; Validated; Region: truA; PRK00021 1310161001547 Eukaryotic and bacterial pseudouridine synthases similar to E. coli TruA; Region: PseudoU_synth_EcTruA; cd02570 1310161001548 dimerization interface 3.5A [polypeptide binding]; other site 1310161001549 active site 1310161001550 Acetyltransferase (GNAT) domain; Region: Acetyltransf_7; pfam13508 1310161001551 Coenzyme A binding pocket [chemical binding]; other site 1310161001552 type VII secretion protein EccB, Actinobacterial; Region: T7SS_EccB; TIGR03919 1310161001553 FAD/FMN-containing dehydrogenases [Energy production and conversion]; Region: GlcD; COG0277 1310161001554 FAD binding domain; Region: FAD_binding_4; pfam01565 1310161001555 Catalytic domain of glycoside hydrolase (GH) families 38 and 57, lactam utilization protein LamB/YcsF family proteins, YdjC-family proteins, and similar proteins; Region: GH38-57_N_LamB_YdjC_SF; cl17191 1310161001556 Cyclopropane fatty acid synthase and related methyltransferases [Cell envelope biogenesis, outer membrane]; Region: Cfa; COG2230 1310161001557 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 1310161001558 S-adenosylmethionine binding site [chemical binding]; other site 1310161001559 TIGR02611 family protein; Region: TIGR02611 1310161001560 type VII secretion-associated serine protease mycosin; Region: T7SS_mycosin; TIGR03921 1310161001561 Peptidase domain in the S8 and S53 families; Region: Peptidases_S8_S53; cd00306 1310161001562 active site 1310161001563 catalytic residues [active] 1310161001564 type VII secretion integral membrane protein EccD; Region: T7SS_EccD; TIGR03920 1310161001565 type VII secretion protein EccCa; Region: T7SS_EccC_a; TIGR03924 1310161001566 FtsK/SpoIIIE family; Region: FtsK_SpoIIIE; pfam01580 1310161001567 type VII secretion protein EccCb; Region: T7SS_EccC_b; TIGR03925 1310161001568 FtsK/SpoIIIE family; Region: FtsK_SpoIIIE; pfam01580 1310161001569 type VII secretion-associated protein, Rv3446c family, C-terminal domain; Region: T7SS_Rv3446c; TIGR03931 1310161001570 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4842 1310161001571 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4842 1310161001572 Ribosomal protein L13. Protein L13, a large ribosomal subunit protein, is one of five proteins required for an early folding intermediate of 23S rRNA in the assembly of the large subunit. L13 is situated on the bottom of the large subunit, near the...; Region: Ribosomal_L13; cd00392 1310161001573 23S rRNA interface [nucleotide binding]; other site 1310161001574 L3 interface [polypeptide binding]; other site 1310161001575 30S ribosomal protein S9; Reviewed; Region: rpsI; PRK00132 1310161001576 phosphoglucosamine mutase; Provisional; Region: glmM; PRK14318 1310161001577 GlmM is a bacterial phosphoglucosamine mutase (PNGM) that belongs to the alpha-D-phosphohexomutase superfamily. It is required for the interconversion of glucosamine-6-phosphate and glucosamine-1-phosphate in the biosynthetic pathway of...; Region: GlmM; cd05802 1310161001578 active site 1310161001579 substrate binding site [chemical binding]; other site 1310161001580 metal binding site [ion binding]; metal-binding site 1310161001581 Alpha/beta hydrolase family; Region: Abhydrolase_5; pfam12695 1310161001582 alanine racemase; Reviewed; Region: alr; PRK00053 1310161001583 Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzyme Alanine Racemase; Region: PLPDE_III_AR; cd00430 1310161001584 active site 1310161001585 pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site 1310161001586 dimer interface [polypeptide binding]; other site 1310161001587 substrate binding site [chemical binding]; other site 1310161001588 catalytic residues [active] 1310161001589 Predicted ATPase or kinase [General function prediction only]; Region: COG0802 1310161001590 Predicted permease [General function prediction only]; Region: COG2985 1310161001591 Predicted Permease Membrane Region; Region: Asp-Al_Ex; pfam06826 1310161001592 TrkA-C domain; Region: TrkA_C; pfam02080 1310161001593 AspT/YidE/YbjL antiporter duplication domain; Region: YidE_YbjL_dupl; TIGR01625 1310161001594 proline iminopeptidase, Neisseria-type subfamily; Region: pro_imino_pep_1; TIGR01249 1310161001595 Inactive homolog of metal-dependent proteases, putative molecular chaperone [Posttranslational modification, protein turnover, chaperones]; Region: COG1214 1310161001596 Glycoprotease family; Region: Peptidase_M22; pfam00814 1310161001597 ribosomal-protein-alanine acetyltransferase; Region: rimI; TIGR01575 1310161001598 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 1310161001599 Coenzyme A binding pocket [chemical binding]; other site 1310161001600 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl17182 1310161001601 UGMP family protein; Validated; Region: PRK09604 1310161001602 Uncharacterized conserved protein [Function unknown]; Region: COG0062 1310161001603 B.subtilis YXKO protein of unknown function and related proteins. Based on the conservation of the ATP binding site, the substrate binding site and the Mg2+binding site and structural homology this group is a member of the ribokinase-like superfamily; Region: YXKO-related; cd01171 1310161001604 putative substrate binding site [chemical binding]; other site 1310161001605 putative ATP binding site [chemical binding]; other site 1310161001606 Chaperonin 10 Kd subunit (cpn10 or GroES); Cpn10 cooperates with chaperonin 60 (cpn60 or GroEL), an ATPase, to assist the folding and assembly of proteins and is found in eubacterial cytosol, as well as in the matrix of mitochondria and chloroplasts. It...; Region: cpn10; cd00320 1310161001607 oligomerisation interface [polypeptide binding]; other site 1310161001608 mobile loop; other site 1310161001609 roof hairpin; other site 1310161001611 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3464 1310161001612 Transposase; Region: DDE_Tnp_ISL3; pfam01610 1310161001614 Transcription factor WhiB; Region: Whib; pfam02467 1310161001615 RNA polymerase sigma factor SigD; Reviewed; Region: PRK09648 1310161001616 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 1310161001617 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 1310161001618 DNA binding residues [nucleotide binding] 1310161001619 inosine 5'-monophosphate dehydrogenase; Reviewed; Region: PRK05567 1310161001620 TIM barrel proteins share a structurally conserved phosphate binding motif and in general share an eight beta/alpha closed barrel structure. Specific for this family is the conserved phosphate binding site at the edges of strands 7 and 8. The phosphate...; Region: TIM_phosphate_binding; cl17186 1310161001621 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains in the inosine 5' monophosphate dehydrogenase (IMPDH) protein. IMPDH is an essential enzyme that catalyzes the first step unique to GTP synthesis, playing a...; Region: CBS_pair_IMPDH; cd04601 1310161001622 IMPDH: The catalytic domain of the inosine monophosphate dehydrogenase. IMPDH catalyzes the NAD-dependent oxidation of inosine 5'-monophosphate (IMP) to xanthosine 5' monophosphate (XMP). It is a rate-limiting step in the de novo synthesis of...; Region: IMPDH; cd00381 1310161001623 active site 1310161001624 IMP dehydrogenase family protein; Region: IMP_DH_rel_2; TIGR01304 1310161001625 TIM barrel proteins share a structurally conserved phosphate binding motif and in general share an eight beta/alpha closed barrel structure. Specific for this family is the conserved phosphate binding site at the edges of strands 7 and 8. The phosphate...; Region: TIM_phosphate_binding; cl17186 1310161001626 phosphate binding site [ion binding]; other site 1310161001627 Threonine/homoserine efflux transporter [Amino acid transport and metabolism]; Region: rhtA; COG5006 1310161001628 EamA-like transporter family; Region: EamA; pfam00892 1310161001629 Transcriptional regulator [Transcription]; Region: LysR; COG0583 1310161001630 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 1310161001631 The C-terminal substrate binding domain of an uncharacterized LysR-type transcriptional regulator, contains the type 2 periplasmic binding fold; Region: PBP2_LTTR_like_6; cd08423 1310161001632 putative dimerization interface [polypeptide binding]; other site 1310161001633 GMP synthase; Reviewed; Region: guaA; PRK00074 1310161001634 Type 1 glutamine amidotransferase (GATase1) domain found in GMP synthetase; Region: GATase1_GMP_Synthase; cd01742 1310161001635 AMP/PPi binding site [chemical binding]; other site 1310161001636 candidate oxyanion hole; other site 1310161001637 catalytic triad [active] 1310161001638 potential glutamine specificity residues [chemical binding]; other site 1310161001639 The C-terminal domain of GMP synthetase. It contains two subdomains; the ATP pyrophosphatase domain which closes to the N-termial and the dimerization domain at C-terminal end. The ATP-PPase is a twisted, five-stranded parallel beta-sheet sandwiched...; Region: GMP_synthase_C; cd01997 1310161001640 ATP Binding subdomain [chemical binding]; other site 1310161001641 Ligand Binding sites [chemical binding]; other site 1310161001642 Dimerization subdomain; other site 1310161001643 Putative stress-responsive transcriptional regulator [Transcription / Signal transduction mechanisms]; Region: PspC; COG1983 1310161001644 Cell wall-active antibiotics response protein (DUF2154); Region: DUF2154; pfam09922 1310161001645 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 1310161001646 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1310161001647 active site 1310161001648 phosphorylation site [posttranslational modification] 1310161001649 intermolecular recognition site; other site 1310161001650 dimerization interface [polypeptide binding]; other site 1310161001651 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 1310161001652 dimerization interface [polypeptide binding]; other site 1310161001653 DNA binding residues [nucleotide binding] 1310161001654 DNA Polymerase Y-family; Region: PolY_like; cd03468 1310161001655 active site 1310161001656 Nucleotidyltransferase/DNA polymerase involved in DNA repair [DNA replication, recombination, and repair]; Region: DinP; COG0389 1310161001657 DNA binding site [nucleotide binding] 1310161001658 TRX-like [2Fe-2S] Ferredoxin (Fd) family, Sucrase subfamily; composed of proteins with similarity to a novel plant enzyme, isolated from potato, which contains a Fd-like domain and exhibits sucrolytic activity. The putative active site of the Fd-like...; Region: TRX_Fd_Sucrase; cd03062 1310161001659 putative dimer interface [polypeptide binding]; other site 1310161001660 putative [2Fe-2S] cluster binding site [ion binding]; other site 1310161001661 prenyltransferase; Reviewed; Region: ubiA; PRK13105 1310161001662 UbiA prenyltransferase family; Region: UbiA; pfam01040 1310161001663 lycopene cyclase domain; Region: CarR_dom_SF; TIGR03462 1310161001664 lycopene cyclase domain; Region: CarR_dom_SF; TIGR03462 1310161001665 phytoene desaturase; Region: crtI_fam; TIGR02734 1310161001666 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450 1310161001667 Trans-Isoprenyl Diphosphate Synthases, head-to-head; Region: Trans_IPPS_HH; cd00683 1310161001668 active site lid residues [active] 1310161001669 substrate binding pocket [chemical binding]; other site 1310161001670 catalytic residues [active] 1310161001671 substrate-Mg2+ binding site; other site 1310161001672 aspartate-rich region 1; other site 1310161001673 aspartate-rich region 2; other site 1310161001674 MMPL family; Region: MMPL; pfam03176 1310161001675 Geranylgeranyl pyrophosphate synthase [Coenzyme metabolism]; Region: IspA; COG0142 1310161001676 Trans-Isoprenyl Diphosphate Synthases, head-to-tail; Region: Trans_IPPS_HT; cd00685 1310161001677 substrate binding pocket [chemical binding]; other site 1310161001678 chain length determination region; other site 1310161001679 substrate-Mg2+ binding site; other site 1310161001680 catalytic residues [active] 1310161001681 aspartate-rich region 1; other site 1310161001682 active site lid residues [active] 1310161001683 aspartate-rich region 2; other site 1310161001684 Bacterial lipocalin [Cell envelope biogenesis, outer membrane]; Region: Blc; COG3040 1310161001685 Lipocalin-like domain; Region: Lipocalin_2; pfam08212 1310161001686 Deoxyribodipyrimidine photolyase [DNA replication, recombination, and repair]; Region: PhrB; COG0415 1310161001687 DNA photolyase; Region: DNA_photolyase; pfam00875 1310161001688 Glycosyltransferases involved in cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WcaA; COG0463 1310161001689 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cd00761 1310161001690 active site 1310161001691 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394 1310161001692 MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704 1310161001693 ABC-type antimicrobial peptide transport system, permease component [Defense mechanisms]; Region: SalY; COG0577 1310161001694 FtsX-like permease family; Region: FtsX; pfam02687 1310161001695 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1310161001696 dimer interface [polypeptide binding]; other site 1310161001697 conserved gate region; other site 1310161001698 putative PBP binding loops; other site 1310161001699 ABC-ATPase subunit interface; other site 1310161001700 ABC-type metal ion transport system, ATPase component [Inorganic ion transport and metabolism]; Region: AbcC; COG1135 1310161001701 ATP-binding cassette domain of methionine transporter; Region: ABC_MetN_methionine_transporter; cd03258 1310161001702 Walker A/P-loop; other site 1310161001703 ATP binding site [chemical binding]; other site 1310161001704 Q-loop/lid; other site 1310161001705 ABC transporter signature motif; other site 1310161001706 Walker B; other site 1310161001707 D-loop; other site 1310161001708 H-loop/switch region; other site 1310161001709 This domain is found at the C-terminus of ABC transporter proteins involved in D-methionine transport as well as a number of ferredoxin-like proteins; Region: NIL; smart00930 1310161001710 ABC-type metal ion transport system, periplasmic component/surface antigen [Inorganic ion transport and metabolism]; Region: NlpA; COG1464 1310161001711 NLPA lipoprotein; Region: Lipoprotein_9; pfam03180 1310161001712 Uncharacterized conserved protein [Function unknown]; Region: COG3402 1310161001713 Predicted membrane protein [Function unknown]; Region: COG3428 1310161001714 Bacterial PH domain; Region: DUF304; pfam03703 1310161001715 Bacterial PH domain; Region: DUF304; cl01348 1310161001716 Bacterial PH domain; Region: DUF304; pfam03703 1310161001717 Mn-dependent transcriptional regulator [Transcription]; Region: TroR; COG1321 1310161001718 Iron dependent repressor, N-terminal DNA binding domain; Region: Fe_dep_repress; pfam01325 1310161001719 Iron dependent repressor, metal binding and dimerisation domain; Region: Fe_dep_repr_C; pfam02742 1310161001720 FeoA domain; Region: FeoA; pfam04023 1310161001721 Predicted membrane-bound metal-dependent hydrolase (DUF457); Region: DUF457; pfam04307 1310161001722 NAD-dependent deacetylase; Provisional; Region: PRK00481 1310161001723 SIRT5_Af1_CobB: Eukaryotic, archaeal and prokaryotic group (class3) which includes human sirtuin SIRT5, Archaeoglobus fulgidus Sir2-Af1, and E. coli CobB; and are members of the SIR2 family of proteins, silent information regulator 2 (Sir2) enzymes which...; Region: SIRT5_Af1_CobB; cd01412 1310161001724 NAD+ binding site [chemical binding]; other site 1310161001725 substrate binding site [chemical binding]; other site 1310161001726 Zn binding site [ion binding]; other site 1310161001727 Nucleoside deaminases include adenosine, guanine and cytosine deaminases. These enzymes are Zn dependent and catalyze the deamination of nucleosides. The zinc ion in the active site plays a central role in the proposed catalytic mechanism, activating a...; Region: nucleoside_deaminase; cd01285 1310161001728 nucleoside/Zn binding site; other site 1310161001729 dimer interface [polypeptide binding]; other site 1310161001730 catalytic motif [active] 1310161001731 Fe3+-siderophore binding domain FhuD. These proteins have been shown to function as initial receptors in ABC transport of Fe3+-siderophores in many eubacterial species. They belong to the TroA-like superfamily of helical backbone metal receptor proteins...; Region: FhuD; cd01146 1310161001732 Periplasmic binding protein; Region: Peripla_BP_2; pfam01497 1310161001733 siderophore binding site; other site 1310161001734 Predicted rRNA methylase (SpoU class) [Translation, ribosomal structure and biogenesis]; Region: CspR; COG0219 1310161001735 bifunctional 5,10-methylene-tetrahydrofolate dehydrogenase/ 5,10-methylene-tetrahydrofolate cyclohydrolase; Provisional; Region: PRK14193 1310161001736 Tetrahydrofolate dehydrogenase/cyclohydrolase, catalytic domain; Region: THF_DHG_CYH; pfam00763 1310161001737 NADP binding domain of methylene-tetrahydrofolate dehydrogenase/cyclohydrolase; Region: NAD_bind_m-THF_DH_Cyclohyd; cd01080 1310161001738 homodimer interface [polypeptide binding]; other site 1310161001739 NADP binding site [chemical binding]; other site 1310161001740 substrate binding site [chemical binding]; other site 1310161001741 Protein of unknown function (DUF3017); Region: DUF3017; pfam11222 1310161001742 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2268 1310161001743 Band_7_flotillin: a subgroup of the band 7 domain of flotillin (reggie) like proteins. This subgroup contains proteins similar to stomatin, prohibitin, flotillin, HlfK/C and podicin. These two proteins are lipid raft-associated. Individual proteins of...; Region: Band_7_flotillin; cd03399 1310161001744 Protein of unknown function (DUF3500); Region: DUF3500; pfam12006 1310161001745 homoserine O-acetyltransferase; Provisional; Region: metX; PRK00175 1310161001746 homoserine O-acetyltransferase; Region: homoserO_Ac_trn; TIGR01392 1310161001747 O-acetylhomoserine aminocarboxypropyltransferase; Validated; Region: PRK05613 1310161001748 CGS_like: Cystathionine gamma-synthase is a PLP dependent enzyme and catalyzes the committed step of methionine biosynthesis. This pathway is unique to microorganisms and plants, rendering the enzyme an attractive target for the development of...; Region: CGS_like; cd00614 1310161001749 homodimer interface [polypeptide binding]; other site 1310161001750 substrate-cofactor binding pocket; other site 1310161001751 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1310161001752 catalytic residue [active] 1310161001753 Carbon starvation protein, predicted membrane protein [Signal transduction mechanisms]; Region: CstA; COG1966 1310161001754 Carbon starvation protein CstA; Region: CstA; pfam02554 1310161001755 C-terminal domain on CstA (DUF4161); Region: DUF4161; pfam13722 1310161001756 Protein of unknown function (DUF466); Region: DUF466; pfam04328 1310161001757 Uncharacterized protein involved in propionate catabolism [General function prediction only]; Region: PrpD; COG2079 1310161001758 Phosphoenolpyruvate phosphomutase; Region: PEP_mutase; pfam13714 1310161001759 Members of the ICL/PEPM enzyme family catalyze either P-C or C-C bond formation/cleavage. Known members are phosphoenolpyruvate mutase (PEPM), phosphonopyruvate hydrolase (PPH), carboxyPEP mutase (CPEP mutase), oxaloacetate hydrolase (OAH), isocitrate...; Region: ICL_PEPM; cd00377 1310161001760 tetramer interface [polypeptide binding]; other site 1310161001761 active site 1310161001762 Mg2+/Mn2+ binding site [ion binding]; other site 1310161001763 citrate synthase; Provisional; Region: PRK14033 1310161001764 Cold-active citrate synthase (CS) from an Antarctic bacterial strain DS2-3R (Ds)-like. CS catalyzes the condensation of acetyl coenzyme A (AcCoA) and oxalacetate (OAA) to form citrate and coenzyme A (CoA), the first step in the citric acid cycle (TCA or...; Region: DsCS_like; cd06111 1310161001765 dimer interface [polypeptide binding]; other site 1310161001766 active site 1310161001767 citrylCoA binding site [chemical binding]; other site 1310161001768 oxalacetate/citrate binding site [chemical binding]; other site 1310161001769 coenzyme A binding site [chemical binding]; other site 1310161001770 catalytic triad [active] 1310161001771 Malate/L-lactate dehydrogenases [Energy production and conversion]; Region: COG2055 1310161001772 Transcriptional regulators [Transcription]; Region: GntR; COG1802 1310161001773 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 1310161001774 DNA-binding site [nucleotide binding]; DNA binding site 1310161001775 FCD domain; Region: FCD; pfam07729 1310161001776 Monomeric isocitrate dehydrogenase [Energy production and conversion]; Region: Icd; COG2838 1310161001777 isocitrate dehydrogenase, NADP-dependent, monomeric type; Region: monomer_idh; TIGR00178 1310161001778 Siderophore-interacting protein [Inorganic ion transport and metabolism]; Region: ViuB; COG2375 1310161001779 Siderophore interacting proteins share the domain structure of the ferredoxin reductase like family. Siderophores are produced in various bacteria (and some plants) to extract iron from hosts. Binding constants are high, so iron can be pilfered from...; Region: siderophore_interacting; cd06193 1310161001780 FAD binding pocket [chemical binding]; other site 1310161001781 FAD binding motif [chemical binding]; other site 1310161001782 phosphate binding motif [ion binding]; other site 1310161001783 NAD binding pocket [chemical binding]; other site 1310161001784 ABC-type cobalamin/Fe3+-siderophores transport systems, ATPase components [Inorganic ion transport and metabolism / Coenzyme metabolism]; Region: FepC; COG1120 1310161001785 ATP-binding component of iron-siderophores, vitamin B12 and hemin transporters and related proteins; Region: ABC_Iron-Siderophores_B12_Hemin; cd03214 1310161001786 Walker A/P-loop; other site 1310161001787 ATP binding site [chemical binding]; other site 1310161001788 Q-loop/lid; other site 1310161001789 ABC transporter signature motif; other site 1310161001790 Walker B; other site 1310161001791 D-loop; other site 1310161001792 H-loop/switch region; other site 1310161001793 ABC-type enterobactin transport system, permease component [Inorganic ion transport and metabolism]; Region: FepG; COG4779 1310161001794 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550 1310161001795 ABC-ATPase subunit interface; other site 1310161001796 dimer interface [polypeptide binding]; other site 1310161001797 putative PBP binding regions; other site 1310161001798 iron-hydroxamate transporter permease subunit; Provisional; Region: PRK10577 1310161001799 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550 1310161001800 ABC-ATPase subunit interface; other site 1310161001801 dimer interface [polypeptide binding]; other site 1310161001802 putative PBP binding regions; other site 1310161001805 Arabinose efflux permease [Carbohydrate transport and metabolism]; Region: AraJ; COG2814 1310161001806 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1310161001807 putative substrate translocation pore; other site 1310161001808 Exonuclease-Endonuclease-Phosphatase (EEP) domain superfamily; Region: EEP; cl00490 1310161001809 putative catalytic site [active] 1310161001810 putative metal binding site [ion binding]; other site 1310161001811 putative phosphate binding site [ion binding]; other site 1310161001812 Predicted membrane protein [Function unknown]; Region: COG2860 1310161001813 UPF0126 domain; Region: UPF0126; pfam03458 1310161001814 UPF0126 domain; Region: UPF0126; pfam03458 1310161001815 Periplasmic binding protein TroA_d. These proteins are predicted to function as initial receptors in the ABC metal ion uptake in eubacteria and archaea. They belong to the TroA superfamily of helical backbone metal receptor proteins that share a...; Region: TroA_d; cd01141 1310161001816 Periplasmic binding protein; Region: Peripla_BP_2; pfam01497 1310161001817 putative ligand binding site [chemical binding]; other site 1310161001818 ABC-type cobalamin/Fe3+-siderophores transport systems, ATPase components [Inorganic ion transport and metabolism / Coenzyme metabolism]; Region: FepC; COG1120 1310161001819 ATP-binding component of iron-siderophores, vitamin B12 and hemin transporters and related proteins; Region: ABC_Iron-Siderophores_B12_Hemin; cd03214 1310161001820 Walker A/P-loop; other site 1310161001821 ATP binding site [chemical binding]; other site 1310161001822 Q-loop/lid; other site 1310161001823 ABC transporter signature motif; other site 1310161001824 Walker B; other site 1310161001825 D-loop; other site 1310161001826 H-loop/switch region; other site 1310161001827 iron-hydroxamate transporter permease subunit; Provisional; Region: PRK10577 1310161001828 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550 1310161001829 ABC-ATPase subunit interface; other site 1310161001830 dimer interface [polypeptide binding]; other site 1310161001831 putative PBP binding regions; other site 1310161001832 tryptophanyl-tRNA synthetase II; Reviewed; Region: PRK12282 1310161001833 catalytic core domain of tryptophanyl-tRNA synthetase; Region: TrpRS_core; cd00806 1310161001834 active site 1310161001835 HIGH motif; other site 1310161001836 dimer interface [polypeptide binding]; other site 1310161001837 KMSKS motif; other site 1310161001838 Ribonuclease BN family enzyme [Replication, recombination, and repair]; Region: Rbn; COG1295 1310161001839 RDD family; Region: RDD; pfam06271 1310161001840 D-alanyl-D-alanine carboxypeptidase [Cell envelope biogenesis, outer membrane]; Region: DacC; COG1686 1310161001841 Beta-lactamase enzyme family; Region: Beta-lactamase2; cl17872 1310161001842 Cell wall-associated hydrolases (invasion-associated proteins) [Cell envelope biogenesis, outer membrane]; Region: Spr; COG0791 1310161001843 NlpC/P60 family; Region: NLPC_P60; pfam00877 1310161001844 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 1310161001845 active site 1310161001846 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 1310161001847 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 1310161001848 non-specific DNA binding site [nucleotide binding]; other site 1310161001849 salt bridge; other site 1310161001850 sequence-specific DNA binding site [nucleotide binding]; other site 1310161001851 Phosphomannomutase [Carbohydrate transport and metabolism]; Region: {ManB}; COG1109 1310161001852 This CD includes PGM2 (phosphoglucomutase 2) and PGM2L1 (phosphoglucomutase 2-like 1). The mammalian PGM2 is thought to be a phosphopentomutase that catalyzes the conversion of the nucleoside breakdown products, ribose-1-phosphate and...; Region: PGM2; cd05799 1310161001853 active site 1310161001854 substrate binding site [chemical binding]; other site 1310161001855 metal binding site [ion binding]; metal-binding site 1310161001856 Metal-dependent amidase/aminoacylase/carboxypeptidase [General function prediction only]; Region: AbgB; COG1473 1310161001857 M20 Peptidase Aminoacylase 1 subfamily; Region: M20_Acy1_like4; cd08014 1310161001858 metal binding site [ion binding]; metal-binding site 1310161001859 putative dimer interface [polypeptide binding]; other site 1310161001860 flavoprotein disulfide reductase; Reviewed; Region: PRK07845 1310161001861 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 1310161001862 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 1310161001863 Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain; Region: Pyr_redox_dim; pfam02852 1310161001864 pyruvate carboxylase; Reviewed; Region: PRK12999 1310161001865 Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289 1310161001866 ATP-grasp domain; Region: ATP-grasp_4; cl17255 1310161001867 Biotin carboxylase C-terminal domain; Region: Biotin_carb_C; smart00878 1310161001868 Pyruvate carboxylase and Transcarboxylase 5S, carboxyltransferase domain; Region: DRE_TIM_PC_TC_5S; cd07937 1310161001869 active site 1310161001870 catalytic residues [active] 1310161001871 metal binding site [ion binding]; metal-binding site 1310161001872 homodimer binding site [polypeptide binding]; other site 1310161001873 The biotinyl-domain or biotin carboxyl carrier protein (BCCP) domain is present in all biotin-dependent enzymes, such as acetyl-CoA carboxylase, pyruvate carboxylase, propionyl-CoA carboxylase, methylcrotonyl-CoA carboxylase, geranyl-CoA carboxylase; Region: biotinyl_domain; cd06850 1310161001874 carboxyltransferase (CT) interaction site; other site 1310161001875 biotinylation site [posttranslational modification]; other site 1310161001876 Thioredoxin domain-containing protein [Posttranslational modification, protein turnover, chaperones]; Region: COG3118 1310161001877 Protein Disulfide Oxidoreductases and Other Proteins with a Thioredoxin fold; Region: Thioredoxin_like; cl00388 1310161001878 Uncharacterized protein with SCP/PR1 domains [Function unknown]; Region: COG2340 1310161001879 SCP_bacterial: SCP-like extracellular protein domain, as found in bacteria and archaea. The wider family of SCP containing proteins includes plant pathogenesis-related protein 1 (PR-1), CRISPs, mammalian cysteine-rich secretory proteins, and allergen 5...; Region: SCP_bacterial; cd05379 1310161001880 Putative GTPases (G3E family) [General function prediction only]; Region: COG0523 1310161001881 CobW/HypB/UreG, nucleotide-binding domain; Region: cobW; pfam02492 1310161001882 Cobalamin synthesis protein cobW C-terminal domain; Region: CobW_C; pfam07683 1310161001883 Thioredoxin reductase [Posttranslational modification, protein turnover, chaperones]; Region: TrxB; COG0492 1310161001884 Uncharacterized protein involved in propionate catabolism [General function prediction only]; Region: PrpD; COG2079 1310161001885 Phosphoenolpyruvate phosphomutase; Region: PEP_mutase; pfam13714 1310161001886 Members of the ICL/PEPM enzyme family catalyze either P-C or C-C bond formation/cleavage. Known members are phosphoenolpyruvate mutase (PEPM), phosphonopyruvate hydrolase (PPH), carboxyPEP mutase (CPEP mutase), oxaloacetate hydrolase (OAH), isocitrate...; Region: ICL_PEPM; cd00377 1310161001887 tetramer interface [polypeptide binding]; other site 1310161001888 active site 1310161001889 Mg2+/Mn2+ binding site [ion binding]; other site 1310161001890 citrate synthase; Provisional; Region: PRK14033 1310161001891 Cold-active citrate synthase (CS) from an Antarctic bacterial strain DS2-3R (Ds)-like. CS catalyzes the condensation of acetyl coenzyme A (AcCoA) and oxalacetate (OAA) to form citrate and coenzyme A (CoA), the first step in the citric acid cycle (TCA or...; Region: DsCS_like; cd06111 1310161001892 dimer interface [polypeptide binding]; other site 1310161001893 active site 1310161001894 citrylCoA binding site [chemical binding]; other site 1310161001895 oxalacetate/citrate binding site [chemical binding]; other site 1310161001896 coenzyme A binding site [chemical binding]; other site 1310161001897 catalytic triad [active] 1310161001898 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 1310161001899 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 1310161001900 non-specific DNA binding site [nucleotide binding]; other site 1310161001901 salt bridge; other site 1310161001902 sequence-specific DNA binding site [nucleotide binding]; other site 1310161001903 Predicted transcriptional regulator [General function prediction only]; Region: COG3800 1310161001904 Domain of unknown function (DUF955); Region: DUF955; pfam06114 1310161001905 Predicted transcriptional regulator (DUF2083); Region: DUF2083; pfam09856 1310161001906 acetyl-CoA carboxylase biotin carboxylase subunit; Validated; Region: PRK08591 1310161001907 Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289 1310161001908 Carbamoyl-phosphate synthase L chain, ATP binding domain; Region: CPSase_L_D2; pfam02786 1310161001909 Biotin carboxylase C-terminal domain; Region: Biotin_carb_C; smart00878 1310161001910 The biotinyl-domain or biotin carboxyl carrier protein (BCCP) domain is present in all biotin-dependent enzymes, such as acetyl-CoA carboxylase, pyruvate carboxylase, propionyl-CoA carboxylase, methylcrotonyl-CoA carboxylase, geranyl-CoA carboxylase; Region: biotinyl_domain; cd06850 1310161001911 carboxyltransferase (CT) interaction site; other site 1310161001912 biotinylation site [posttranslational modification]; other site 1310161001913 Rhodanese-related sulfurtransferase [Inorganic ion transport and metabolism]; Region: SseA; COG2897 1310161001914 Thiosulfate sulfurtransferase (TST), N-terminal, inactive domain. TST contains 2 copies of the Rhodanese Homology Domain; this is the 1st repeat, which does not contain the catalytically active Cys residue. The role of the 1st repeat is uncertain, but it...; Region: TST_Repeat_1; cd01448 1310161001915 active site residue [active] 1310161001916 Thiosulfate sulfurtransferase (TST), C-terminal, catalytic domain. TST contains 2 copies of the Rhodanese Homology Domain; this is the second repeat. Only the second repeat contains the catalytically active Cys residue; Region: TST_Repeat_2; cd01449 1310161001917 active site residue [active] 1310161001918 Protein of unknown function (DUF3151); Region: DUF3151; pfam11349 1310161001919 Predicted acyltransferases [Lipid metabolism]; Region: COG1835 1310161001920 CLC voltage-gated chloride channel. The ClC chloride channels catalyse the selective flow of Cl- ions across cell membranes, thereby regulating electrical excitation in skeletal muscle and the flow of salt and water across epithelial barriers. This...; Region: Voltage_gated_ClC; cl02915 1310161001921 Maf-like protein; Region: Maf; pfam02545 1310161001922 Nucleotide binding protein Maf. Maf has been implicated in inhibition of septum formation in eukaryotes, bacteria and archaea, but homologs in B.subtilis and S.cerevisiae are nonessential for cell division. Maf has been predicted to be a nucleotide- or...; Region: Maf; cd00555 1310161001923 active site 1310161001924 dimer interface [polypeptide binding]; other site 1310161001925 Acyl-CoA carboxylase epsilon subunit; Region: ACC_epsilon; pfam13822 1310161001926 Acetyl-CoA carboxylase, carboxyltransferase component (subunits alpha and beta) [Lipid metabolism]; Region: COG4799 1310161001927 malonate decarboxylase subunit beta; Reviewed; Region: PRK07189; cl17682 1310161001928 Acetyl-CoA carboxylase alpha subunit [Lipid metabolism]; Region: AccA; cl17345 1310161001929 Acetyl-CoA carboxylase, carboxyltransferase component (subunits alpha and beta) [Lipid metabolism]; Region: COG4799 1310161001930 malonate decarboxylase subunit beta; Reviewed; Region: PRK07189; cl17682 1310161001931 Acetyl-CoA carboxylase alpha subunit [Lipid metabolism]; Region: AccA; cl17345 1310161001932 Biotin/lipoate A/B protein ligase family; Region: BPL_LplA_LipB; cl14057 1310161001933 Biotin-(acetyl-CoA carboxylase) ligase [Coenzyme metabolism]; Region: BirA; COG0340 1310161001934 phosphoribosylaminoimidazole carboxylase ATPase subunit; Reviewed; Region: PRK06019 1310161001935 ATP-grasp domain; Region: ATP-grasp; pfam02222 1310161001936 K+ transporter [Inorganic ion transport and metabolism]; Region: Kup; COG3158 1310161001937 Phosphoribosylcarboxyaminoimidazole (NCAIR) mutase [Nucleotide transport and metabolism]; Region: PurE; COG0041 1310161001938 Uncharacterized conserved protein [Function unknown]; Region: COG1434 1310161001939 YdcF-like. YdcF-like is a large family of mainly bacterial proteins, with a few members found in fungi, plants, and archaea. Escherichia coli YdcF has been shown to bind S-adenosyl-L-methionine (AdoMet), but a biochemical function has not been...; Region: YdcF-like; cd06259 1310161001940 putative active site [active] 1310161001941 Thioesterase-like superfamily; Region: 4HBT_3; pfam13622 1310161001942 FMN-dependent oxidoreductase, nitrilotriacetate monooxygenase family; Region: FMN_nitrolo; TIGR03860 1310161001943 nitrilotriacetate monoxygenase oxidizes nitrilotriacetate utilizing reduced flavin mononucleotide (FMNH2) and oxygen. The FMNH2 is provided by an NADH:flavin mononucleotide (FMN) oxidorductase that uses NADH to reduce FMN to FMNH2; Region: Nitrilotriacetate_monoxgenase; cd01095 1310161001944 active site 1310161001945 non-prolyl cis peptide bond; other site 1310161001946 Winged helix-turn helix; Region: HTH_29; pfam13551 1310161001947 Helix-turn-helix domain; Region: HTH_28; pfam13518 1310161001948 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: Tra5; COG2801 1310161001949 Integrase core domain; Region: rve; pfam00665 1310161001950 Integrase core domain; Region: rve_3; pfam13683 1310161001951 3-ketoacyl-(acyl-carrier-protein) reductase; Provisional; Region: fabG; PRK08642 1310161001952 putative beta-ketoacyl acyl carrier protein [ACP]reductase (BKR), subgroup 2, classical (c) SDR; Region: BKR_2_SDR_c; cd05349 1310161001953 putative NAD(P) binding site [chemical binding]; other site 1310161001954 active site 1310161001955 Dihydrofolate reductase [Coenzyme metabolism]; Region: FolA; COG0262 1310161001956 RibD C-terminal domain; Region: RibD_C; cl17279 1310161001957 This conserved domain belongs to a superfamily including the bleomycin resistance protein, glyoxalase I, and type I ring-cleaving dioxygenases; Region: Glo_EDI_BRP_like_7; cd08353 1310161001958 putative dimer interface [polypeptide binding]; other site 1310161001959 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 1310161001960 ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395 1310161001961 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1310161001962 dimer interface [polypeptide binding]; other site 1310161001963 conserved gate region; other site 1310161001964 putative PBP binding loops; other site 1310161001965 ABC-ATPase subunit interface; other site 1310161001966 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1310161001967 dimer interface [polypeptide binding]; other site 1310161001968 conserved gate region; other site 1310161001969 putative PBP binding loops; other site 1310161001970 ABC-ATPase subunit interface; other site 1310161001971 Putative hydrophobic ligand-binding SRPBCC domain of an uncharacterized subgroup of CalC- and Aha1-like proteins; Region: SRPBCC_CalC_Aha1-like_8; cd08901 1310161001972 putative hydrophobic ligand binding site [chemical binding]; other site 1310161001973 Bacterial extracellular solute-binding protein; Region: SBP_bac_8; pfam13416 1310161001974 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; pfam01547 1310161001975 glycerol-3-phosphate transporter ATP-binding subunit; Provisional; Region: ugpC; PRK11650 1310161001976 The N-terminal ATPase domain of the maltose transporter, MalK; Region: ABC_MalK_N; cd03301 1310161001977 Walker A/P-loop; other site 1310161001978 ATP binding site [chemical binding]; other site 1310161001979 Q-loop/lid; other site 1310161001980 ABC transporter signature motif; other site 1310161001981 Walker B; other site 1310161001982 D-loop; other site 1310161001983 H-loop/switch region; other site 1310161001984 TOBE domain; Region: TOBE_2; pfam08402 1310161001985 Distinct helicase family with a unique C-terminal domain including a metal-binding cysteine cluster [General function prediction only]; Region: COG1205 1310161001986 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 1310161001987 ATP binding site [chemical binding]; other site 1310161001988 putative Mg++ binding site [ion binding]; other site 1310161001989 helicase superfamily c-terminal domain; Region: HELICc; smart00490 1310161001990 ATP-binding site [chemical binding]; other site 1310161001991 Domain of unknown function (DUF1998); Region: DUF1998; pfam09369 1310161001992 TIGR03089 family protein; Region: TIGR03089 1310161001993 Protein of unknown function DUF262; Region: DUF262; pfam03235 1310161001994 Uncharacterized conserved protein [Function unknown]; Region: COG1479 1310161001995 Protein of unknown function (DUF1524); Region: DUF1524; pfam07510 1310161001996 Superfamily I DNA and RNA helicases [DNA replication, recombination, and repair]; Region: UvrD; COG0210 1310161001997 Family description; Region: UvrD_C_2; pfam13538 1310161001998 Distinct helicase family with a unique C-terminal domain including a metal-binding cysteine cluster [General function prediction only]; Region: COG1205 1310161001999 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 1310161002000 ATP binding site [chemical binding]; other site 1310161002001 putative Mg++ binding site [ion binding]; other site 1310161002002 Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408 1310161002003 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 1310161002004 ATP-binding site [chemical binding]; other site 1310161002005 Domain of unknown function (DUF1998); Region: DUF1998; pfam09369 1310161002006 Type II restriction enzyme, methylase subunits [Defense mechanisms]; Region: COG1002 1310161002007 Superfamily II DNA/RNA helicases, SNF2 family [Transcription / DNA replication, recombination, and repair]; Region: HepA; COG0553 1310161002008 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 1310161002009 ATP binding site [chemical binding]; other site 1310161002010 putative Mg++ binding site [ion binding]; other site 1310161002011 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 1310161002012 nucleotide binding region [chemical binding]; other site 1310161002013 ATP-binding site [chemical binding]; other site 1310161002014 Transcriptional regulator [Transcription]; Region: LytR; COG1316 1310161002015 LytR cell envelope-related transcriptional attenuator; Region: LytR_C; pfam13399 1310161002016 Predicted glycosyltransferases [General function prediction only]; Region: COG1216 1310161002017 Subfamily of Glycosyltransferase Family GT2 of unknown function; Region: GT_2_like_c; cd04186 1310161002018 Probable Catalytic site; other site 1310161002019 metal-binding site 1310161002020 Nucleoside-diphosphate-sugar pyrophosphorylase involved in lipopolysaccharide biosynthesis/translation initiation factor 2B, gamma/epsilon subunits (eIF-2Bgamma/eIF-2Bepsilon) [Cell envelope biogenesis, outer membrane / Translation, ribosomal structure...; Region: GCD1; COG1208 1310161002021 NTP_transferases catalyze the transfer of nucleotides onto phosphosugars; Region: NTP_transferase; cd04181 1310161002022 active site 1310161002023 Substrate binding site; other site 1310161002024 Mg++ binding site; other site 1310161002025 Left-handed parallel beta-Helix (LbetaH or LbH) domain: The alignment contains 5 turns, each containing three imperfect tandem repeats of a hexapeptide repeat motif (X-[STAV]-X-[LIV]-[GAED]-X). Proteins containing hexapeptide repeats are often enzymes...; Region: LbetaH; cl00160 1310161002026 putative trimer interface [polypeptide binding]; other site 1310161002027 putative CoA binding site [chemical binding]; other site 1310161002028 Transcription factor WhiB; Region: Whib; pfam02467 1310161002029 Minimal MMP-like domain found in a group of hypothetical proteins from alphaproteobacteria and actinobacteria; Region: MMP_TTHA0227_like_1; cd12954 1310161002030 Protein of unknown function (DUF3499); Region: DUF3499; pfam12005 1310161002031 The phosphomannomutase/phosphoglucomutase (PMM/PGM) bifunctional enzyme catalyzes the reversible conversion of 1-phospho to 6-phospho-sugars (e.g. between mannose-1-phosphate and mannose-6-phosphate or glucose-1-phosphate and glucose-6-phosphate) via a...; Region: PMM_PGM; cd03089 1310161002032 phosphomannomutase/phosphoglucomutase; Reviewed; Region: manB; PRK09542 1310161002033 active site 1310161002034 substrate binding site [chemical binding]; other site 1310161002035 metal binding site [ion binding]; metal-binding site 1310161002036 mannose-6-phosphate isomerase; Provisional; Region: PRK15131 1310161002037 Alpha-Mannosidase Binding Domain of Atg19/34; Region: ABD; cl15429 1310161002038 Alpha-Mannosidase Binding Domain of Atg19/34; Region: ABD; cl15429 1310161002039 Domain of unknown function (DUF4259); Region: DUF4259; pfam14078 1310161002040 S-adenosyl-L-homocysteine hydrolase; Provisional; Region: PRK05476 1310161002041 S-Adenosylhomocysteine Hydrolase, NAD-binding and catalytic domains; Region: SAHH; cd00401 1310161002042 homotetramer interface [polypeptide binding]; other site 1310161002043 ligand binding site [chemical binding]; other site 1310161002044 catalytic site [active] 1310161002045 NAD binding site [chemical binding]; other site 1310161002046 Thymidylate kinase [Nucleotide transport and metabolism]; Region: Tmk; COG0125 1310161002047 Thymidine monophosphate kinase (TMPK), also known as thymidylate kinase, catalyzes the phosphorylation of thymidine monophosphate (TMP) to thymidine diphosphate (TDP) utilizing ATP as its preferred phophoryl donor. TMPK represents the rate-limiting step...; Region: TMPK; cd01672 1310161002048 TMP-binding site; other site 1310161002049 ATP-binding site [chemical binding]; other site 1310161002050 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 1310161002051 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1310161002052 active site 1310161002053 phosphorylation site [posttranslational modification] 1310161002054 intermolecular recognition site; other site 1310161002055 dimerization interface [polypeptide binding]; other site 1310161002056 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 1310161002057 DNA binding site [nucleotide binding] 1310161002058 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 1310161002059 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 1310161002060 dimerization interface [polypeptide binding]; other site 1310161002061 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 1310161002062 dimer interface [polypeptide binding]; other site 1310161002063 phosphorylation site [posttranslational modification] 1310161002064 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1310161002065 ATP binding site [chemical binding]; other site 1310161002066 Mg2+ binding site [ion binding]; other site 1310161002067 G-X-G motif; other site 1310161002068 lipoprotein LpqB; Provisional; Region: PRK13616 1310161002069 Sporulation and spore germination; Region: Germane; pfam10646 1310161002070 Predicted amidophosphoribosyltransferases [General function prediction only]; Region: ComFC; COG1040 1310161002071 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 1310161002072 active site 1310161002073 RaiA ("ribosome-associated inhibitor A", also known as Protein Y (PY), YfiA, and SpotY, is a stress-response protein that binds the ribosomal subunit interface and arrests translation by interfering with aminoacyl-tRNA binding to the ribosomal...; Region: RaiA; cd00552 1310161002074 30S subunit binding site; other site 1310161002075 preprotein translocase subunit SecA; Reviewed; Region: PRK12904 1310161002076 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cl17251 1310161002077 SecA preprotein cross-linking domain; Region: SecA_PP_bind; smart00958 1310161002078 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cl17351 1310161002079 nucleotide binding region [chemical binding]; other site 1310161002080 Haloacid dehalogenase-like hydrolase; Region: HAD_2; pfam13419 1310161002081 REG-2-like, HAD superfamily (subfamily IA) hydrolase; Region: DREG-2; TIGR02252 1310161002082 Predicted GTPases [General function prediction only]; Region: COG1162 1310161002083 Ribosomal interacting GTPase YjeQ/EngC, a circularly permuted subfamily of the Ras GTPases; Region: YjeQ_EngC; cd01854 1310161002084 GTPase/Zn-binding domain interface [polypeptide binding]; other site 1310161002085 GTP/Mg2+ binding site [chemical binding]; other site 1310161002086 G4 box; other site 1310161002087 G1 box; other site 1310161002088 Switch I region; other site 1310161002089 G2 box; other site 1310161002090 G3 box; other site 1310161002091 Switch II region; other site 1310161002092 Uncharacterized conserved protein [Function unknown]; Region: COG2135 1310161002093 HNH nucleases; HNH endonuclease signature which is found in viral, prokaryotic, and eukaryotic proteins. The alignment includes members of the large group of homing endonucleases, yeast intron 1 protein, MutS, as well as bacterial colicins, pyocins, and...; Region: HNHc; cd00085 1310161002094 active site 1310161002095 RNA polymerase sigma-70 factor, TIGR02947 family; Region: SigH_actino 1310161002096 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 1310161002097 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 1310161002098 DNA binding residues [nucleotide binding] 1310161002099 mycothiol system anti-sigma-R factor; Region: antisig_RsrA; TIGR03988 1310161002100 Transcription factor WhiB; Region: Whib; pfam02467 1310161002101 PQQ-like domain; Region: PQQ_2; pfam13360 1310161002102 DEAD-box helicases. A diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker B motif; Region: DEADc; cd00268 1310161002103 DEAD-like helicases superfamily; Region: DEXDc; smart00487 1310161002104 ATP binding site [chemical binding]; other site 1310161002105 Mg++ binding site [ion binding]; other site 1310161002106 motif III; other site 1310161002107 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 1310161002108 nucleotide binding region [chemical binding]; other site 1310161002109 ATP-binding site [chemical binding]; other site 1310161002110 Protein of unknown function (DUF3107); Region: DUF3107; pfam11305 1310161002111 Protein of unknown function (DUF3152); Region: DUF3152; pfam11350 1310161002112 TIGR02569 family protein; Region: TIGR02569_actnb 1310161002113 Superfamily I DNA and RNA helicases [DNA replication, recombination, and repair]; Region: UvrD; COG0210 1310161002114 RecB family exonuclease [DNA replication, recombination, and repair]; Region: COG2887 1310161002115 Superfamily I DNA and RNA helicases [DNA replication, recombination, and repair]; Region: UvrD; COG0210 1310161002116 Family description; Region: UvrD_C_2; pfam13538 1310161002117 RecB family exonuclease [DNA replication, recombination, and repair]; Region: COG2887 1310161002118 Ion channel; Region: Ion_trans_2; pfam07885 1310161002119 Kef-type K+ transport systems, predicted NAD-binding component [Inorganic ion transport and metabolism]; Region: Kch; COG1226 1310161002120 TrkA-N domain; Region: TrkA_N; pfam02254 1310161002121 NTP pyrophosphohydrolases containing a Zn-finger, probably nucleic-acid-binding [DNA replication, recombination, and repair]; Region: NPY1; COG2816 1310161002122 NADH pyrophosphatase, a member of the Nudix hydrolase superfamily, catalyzes the cleavage of NADH into reduced nicotinamide mononucleotide (NMNH) and AMP. Like other members of the Nudix family, it requires a divalent cation, such as Mg2+ or Mn2+, for...; Region: NADH_pyrophosphatase; cd03429 1310161002123 putative NADH binding site [chemical binding]; other site 1310161002124 putative active site [active] 1310161002125 nudix motif; other site 1310161002126 putative metal binding site [ion binding]; other site 1310161002127 Superfamily I DNA and RNA helicases [DNA replication, recombination, and repair]; Region: UvrD; COG0210 1310161002128 Part of AAA domain; Region: AAA_19; pfam13245 1310161002129 Family description; Region: UvrD_C_2; pfam13538 1310161002130 HRDC domain; Region: HRDC; pfam00570 1310161002131 Uncharacterized conserved protein [Function unknown]; Region: COG5282 1310161002132 uncharacterized protein, coenzyme F420 biosynthesis associated; Region: DUF2342_F420; TIGR03883 1310161002133 Predicted secreted protein containing a PDZ domain [Signal transduction mechanisms]; Region: SdrC; COG3480 1310161002134 PDZ domain of bacterial and plant zinc metalloprotases, presumably membrane-associated or integral membrane proteases, which may be involved in signalling and regulatory mechanisms. May be responsible for substrate recognition and/or binding, as most PDZ...; Region: PDZ_metalloprotease; cd00989 1310161002135 Lon protease (S16) C-terminal proteolytic domain; Region: Lon_C; pfam05362 1310161002136 hypothetical protein; Validated; Region: PRK00068 1310161002137 Uncharacterized conserved protein [Function unknown]; Region: COG1615 1310161002138 Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain (MocR family) and their eukaryotic orthologs [Transcription / Amino acid transport and metabolism]; Region: ARO8; COG1167 1310161002139 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 1310161002140 DNA-binding site [nucleotide binding]; DNA binding site 1310161002141 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 1310161002142 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1310161002143 homodimer interface [polypeptide binding]; other site 1310161002144 pyridoxal 5'-phosphate synthase, synthase subunit Pdx1; Region: TIGR00343 1310161002145 PdxS is a subunit of the pyridoxal 5'-phosphate (PLP) synthase, an important enzyme in deoxyxylulose 5-phosphate (DXP)-independent pathway for de novo biosynthesis of PLP, present in some eubacteria, in archaea, fungi, plants, plasmodia, and some...; Region: pdxS; cd04727 1310161002146 active site 1310161002147 multimer interface [polypeptide binding]; other site 1310161002148 Glutamine Amidotransferase (GATase_I) involved in pyridoxine biosynthesis; Region: GATase1_PB; cd01749 1310161002149 predicted active site [active] 1310161002150 catalytic triad [active] 1310161002151 Trypsin-like serine protease; Many of these are synthesized as inactive precursor zymogens that are cleaved during limited proteolysis to generate their active forms. Alignment contains also inactive enzymes that have substitutions of the catalytic triad...; Region: Tryp_SPc; cl00149 1310161002152 substrate binding sites [chemical binding]; other site 1310161002153 Uncharacterized protein potentially involved in peptidoglycan biosynthesis [Cell envelope biogenesis, outer membrane]; Region: COG5479 1310161002154 LGFP repeat; Region: LGFP; pfam08310 1310161002155 LGFP repeat; Region: LGFP; pfam08310 1310161002156 LGFP repeat; Region: LGFP; pfam08310 1310161002157 Archaeal fructose-1,6-bisphosphatase and related enzymes of inositol monophosphatase family [Carbohydrate transport and metabolism]; Region: SuhB; COG0483 1310161002158 Predominantly bacterial family of Mg++ dependend phosphatases, related to inositol monophosphatases. These enzymes may dephosphorylate fructose-1,6-bisphosphate, inositol monophospate, 3'-phosphoadenosine-5'-phosphate, or similar substrates; Region: Bacterial_IMPase_like_1; cd01641 1310161002159 active site 1310161002160 Inositol-monophosphatase-like domains. This family of phosphatases is dependent on bivalent metal ions such as Mg++, and many members are inhibited by Li+ (which is thought to displace a bivalent ion in the active site). Substrates include fructose-1; Region: IMPase_like; cd01637 1310161002161 Archaeal fructose-1,6-bisphosphatase and related enzymes of inositol monophosphatase family [Carbohydrate transport and metabolism]; Region: SuhB; COG0483 1310161002162 active site 1310161002163 peptide chain release factor 2; Validated; Region: prfB; PRK00578 1310161002164 This domain is found in peptide chain release factors; Region: PCRF; smart00937 1310161002165 RF-1 domain; Region: RF-1; pfam00472 1310161002166 Predicted ATPase involved in cell division [Cell division and chromosome partitioning]; Region: FtsE; COG2884 1310161002167 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 1310161002168 Walker A/P-loop; other site 1310161002169 ATP binding site [chemical binding]; other site 1310161002170 Q-loop/lid; other site 1310161002171 ABC transporter signature motif; other site 1310161002172 Walker B; other site 1310161002173 D-loop; other site 1310161002174 H-loop/switch region; other site 1310161002175 Cell division protein [Cell division and chromosome partitioning]; Region: FtsX; COG2177 1310161002176 FtsX-like permease family; Region: FtsX; pfam02687 1310161002177 Small protein B (SmpB) is a component of the trans-translation system in prokaryotes for releasing stalled ribosome from damaged messenger RNAs; Region: SmpB; cd09294 1310161002178 SmpB-tmRNA interface; other site 1310161002179 Uncharacterized conserved protein [Function unknown]; Region: COG3189 1310161002180 Putative transposase of IS4/5 family (DUF4096); Region: DUF4096; pfam13340 1310161002181 Siderophore-interacting protein [Inorganic ion transport and metabolism]; Region: ViuB; COG2375 1310161002182 Siderophore interacting proteins share the domain structure of the ferredoxin reductase like family. Siderophores are produced in various bacteria (and some plants) to extract iron from hosts. Binding constants are high, so iron can be pilfered from...; Region: siderophore_interacting; cd06193 1310161002183 FAD binding pocket [chemical binding]; other site 1310161002184 FAD binding motif [chemical binding]; other site 1310161002185 phosphate binding motif [ion binding]; other site 1310161002186 NAD binding pocket [chemical binding]; other site 1310161002187 Fe3+-siderophore binding domain FhuD. These proteins have been shown to function as initial receptors in ABC transport of Fe3+-siderophores in many eubacterial species. They belong to the TroA-like superfamily of helical backbone metal receptor proteins...; Region: FhuD; cd01146 1310161002188 Periplasmic binding protein; Region: Peripla_BP_2; pfam01497 1310161002189 siderophore binding site; other site 1310161002190 Vitamin K epoxide reductase family in bacteria; Region: VKOR_5; cd12922 1310161002191 putative active site [active] 1310161002192 redox center [active] 1310161002193 ABC-type enterochelin transport system, periplasmic component [Inorganic ion transport and metabolism]; Region: CeuA; COG4607 1310161002194 Helical backbone metal receptor (TroA-like domain). These proteins have been shown to function in the ABC transport of ferric siderophores and metal ions such as Mn2+, Fe3+, Cu2+ and/or Zn2+. Their ligand binding site is formed in the interface between...; Region: TroA-like; cl00262 1310161002195 intersubunit interface [polypeptide binding]; other site 1310161002196 iron-hydroxamate transporter permease subunit; Provisional; Region: PRK10577 1310161002197 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550 1310161002198 ABC-ATPase subunit interface; other site 1310161002199 dimer interface [polypeptide binding]; other site 1310161002200 putative PBP binding regions; other site 1310161002201 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550 1310161002202 ABC-ATPase subunit interface; other site 1310161002203 dimer interface [polypeptide binding]; other site 1310161002204 putative PBP binding regions; other site 1310161002205 ABC-type enterochelin transport system, ATPase component [Inorganic ion transport and metabolism]; Region: CeuD; COG4604 1310161002206 ATP-binding component of iron-siderophores, vitamin B12 and hemin transporters and related proteins; Region: ABC_Iron-Siderophores_B12_Hemin; cd03214 1310161002207 Walker A/P-loop; other site 1310161002208 ATP binding site [chemical binding]; other site 1310161002209 Q-loop/lid; other site 1310161002210 ABC transporter signature motif; other site 1310161002211 Walker B; other site 1310161002212 D-loop; other site 1310161002213 H-loop/switch region; other site 1310161002214 aminotransferase; Validated; Region: PRK07777 1310161002215 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 1310161002216 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1310161002217 homodimer interface [polypeptide binding]; other site 1310161002218 catalytic residue [active] 1310161002219 Protein of unknown function (DUF3239); Region: DUF3239; pfam11580 1310161002220 Helicase conserved C-terminal domain; Region: Helicase_C_3; pfam13625 1310161002221 DNA or RNA helicases of superfamily II [Transcription / DNA replication, recombination, and repair]; Region: SSL2; COG1061 1310161002222 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 1310161002223 ATP binding site [chemical binding]; other site 1310161002224 putative Mg++ binding site [ion binding]; other site 1310161002225 helicase superfamily c-terminal domain; Region: HELICc; smart00490 1310161002226 Helicase conserved C-terminal domain; Region: Helicase_C_3; pfam13625 1310161002227 Transglycosylase-like domain; Region: Transglycosylas; pfam06737 1310161002228 Protein of unknown function (DUF3235); Region: DUF3235; pfam11574 1310161002229 Cold-Shock Protein (CSP) contains an S1-like cold-shock domain (CSD) that is found in eukaryotes, prokaryotes, and archaea. CSP's include the major cold-shock proteins CspA and CspB in bacteria and the eukaryotic gene regulatory factor Y-box...; Region: CSP_CDS; cd04458 1310161002230 DNA-binding site [nucleotide binding]; DNA binding site 1310161002231 RNA-binding motif; other site 1310161002232 Protein of unknown function (DUF2771); Region: DUF2771; pfam10969 1310161002233 Glutamine cyclotransferase [Posttranslational modification, protein turnover, chaperones]; Region: COG3823 1310161002234 substrate-cofactor binding pocket; other site 1310161002235 homodimer interface [polypeptide binding]; other site 1310161002236 Branched-chain amino acid aminotransferase/4-amino-4-deoxychorismate lyase [Amino acid transport and metabolism / Coenzyme metabolism]; Region: IlvE; COG0115 1310161002237 PyridoxaL 5'-Phosphate Dependent Enzymes class IV (PLPDE_IV). This D-amino acid superfamily, one of five classes of PLPDE, consists of branched-chain amino acid aminotransferases (BCAT), D-amino acid transferases (DAAT), and...; Region: PLPDE_IV; cl00224 1310161002238 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1310161002239 catalytic residue [active] 1310161002240 Xanthine/uracil/vitamin C permease [Nucleotide transport and metabolism]; Region: COG2252 1310161002241 rRNA methylases [Translation, ribosomal structure and biogenesis]; Region: SpoU; COG0566 1310161002242 RNA 2'-O ribose methyltransferase substrate binding; Region: SpoU_sub_bind; cl06870 1310161002243 SpoU rRNA Methylase family; Region: SpoU_methylase; pfam00588 1310161002244 Protein of unknown function (DUF3071); Region: DUF3071; pfam11268 1310161002245 phosphoserine aminotransferase, putative; Region: serC_3; TIGR01366 1310161002246 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 1310161002247 catalytic residue [active] 1310161002248 Escherichia coli (Ec) citrate synthase (CS) GltA_like. CS catalyzes the condensation of acetyl coenzyme A (AcCoA) and oxalacetate (OAA) to form citrate and coenzyme A (CoA), the first step in the citric acid cycle (TCA or Krebs cycle). The overall CS...; Region: EcCS_like; cd06114 1310161002249 Citrate synthase [Energy production and conversion]; Region: GltA; COG0372 1310161002250 dimer interface [polypeptide binding]; other site 1310161002251 active site 1310161002252 citrylCoA binding site [chemical binding]; other site 1310161002253 NADH binding [chemical binding]; other site 1310161002254 cationic pore residues; other site 1310161002255 oxalacetate/citrate binding site [chemical binding]; other site 1310161002256 coenzyme A binding site [chemical binding]; other site 1310161002257 catalytic triad [active] 1310161002258 FKBP-type peptidyl-prolyl cis-trans isomerases 1 [Posttranslational modification, protein turnover, chaperones]; Region: FkpA; COG0545 1310161002259 FKBP-type peptidyl-prolyl cis-trans isomerase; Region: FKBP_C; pfam00254 1310161002260 Predicted membrane protein [Function unknown]; Region: COG3162 1310161002261 Predicted symporter [General function prediction only]; Region: DhlC; COG4147 1310161002262 Uncharacterized bacterial solute carrier 5 subfamily; putative solute-binding domain; Region: SLC5sbd_u4; cd11480 1310161002263 Na binding site [ion binding]; other site 1310161002264 Domain of unknown function (DUF1906); Region: DUF1906; pfam08924 1310161002265 (acyl-carrier-protein) S-malonyltransferase [Lipid metabolism]; Region: FabD; COG0331 1310161002266 Enoyl reductase domain of yeast-type FAS1 [Lipid metabolism]; Region: COG4981 1310161002267 TIM barrel proteins share a structurally conserved phosphate binding motif and in general share an eight beta/alpha closed barrel structure. Specific for this family is the conserved phosphate binding site at the edges of strands 7 and 8. The phosphate...; Region: TIM_phosphate_binding; cl17186 1310161002268 phosphate binding site [ion binding]; other site 1310161002269 Domain of unknown function (DUF1729); Region: DUF1729; pfam08354 1310161002270 The hotdog fold was initially identified in the E. coli FabA (beta-hydroxydecanoyl-acyl carrier protein (ACP)-dehydratase) structure and subsequently in 4HBT (4-hydroxybenzoyl-CoA thioesterase) from Pseudomonas. A number of other seemingly unrelated...; Region: hot_dog; cl00509 1310161002271 active site 2 [active] 1310161002272 active site 1 [active] 1310161002273 (acyl-carrier-protein) S-malonyltransferase [Lipid metabolism]; Region: FabD; COG0331 1310161002274 malonyl CoA-acyl carrier protein transacylase; Region: fabD; TIGR00128 1310161002275 3-oxoacyl-[acyl-carrier protein]; Region: COG4982 1310161002276 ketoacyl reductase (KR) domain of fungal-type fatty acid synthase (fFAS), classical (c)-like SDRs; Region: KR_fFAS_SDR_c_like; cd08950 1310161002277 putative NAD(P) binding site [chemical binding]; other site 1310161002278 active site 1310161002279 "elongating" condensing enzymes are a subclass of decarboxylating condensing enzymes, including beta-ketoacyl [ACP] synthase, type I and II and polyketide synthases.They are characterized by the utlization of acyl carrier protein (ACP)...; Region: elong_cond_enzymes; cd00828 1310161002280 3-oxoacyl-(acyl-carrier-protein) synthase [Lipid metabolism / Secondary metabolites biosynthesis, transport, and catabolism]; Region: FabB; COG0304 1310161002281 active site 1310161002282 Septum formation; Region: Septum_form; pfam13845 1310161002283 Homoserine acetyltransferase [Amino acid transport and metabolism]; Region: MET2; COG2021 1310161002284 hypothetical protein; Validated; Region: PRK07581 1310161002285 NrdH-redoxin (NrdH) family; NrdH is a small monomeric protein with a conserved redox active CXXC motif within a TRX fold, characterized by a glutaredoxin (GRX)-like sequence and TRX-like activity profile. In vitro, it displays protein disulfide reductase...; Region: NrdH; cd02976 1310161002286 catalytic residues [active] 1310161002287 Dihydrofolate reductase [Coenzyme metabolism]; Region: FolA; COG0262 1310161002288 Dihydrofolate reductase (DHFR). Reduces 7,8-dihydrofolate to 5,6,7,8-tetrahydrofolate with NADPH as a cofactor. This is an essential step in the biosynthesis of deoxythymidine phosphate since 5,6,7,8-tetrahydrofolate is required to regenerate 5; Region: DHFR; cd00209 1310161002289 folate binding site [chemical binding]; other site 1310161002290 NADP+ binding site [chemical binding]; other site 1310161002291 thymidylate synthase; Reviewed; Region: thyA; PRK01827 1310161002292 Thymidylate synthase and pyrimidine hydroxymethylase: Thymidylate synthase (TS) and deoxycytidylate hydroxymethylase (dCMP-HMase) are homologs that catalyze analogous alkylation of C5 of pyrimidine nucleotides. Both enzymes are involved in the...; Region: TS_Pyrimidine_HMase; cd00351 1310161002293 dimerization interface [polypeptide binding]; other site 1310161002294 active site 1310161002295 CysQ, a 3'-Phosphoadenosine-5'-phosphosulfate (PAPS) 3'-phosphatase, is a bacterial member of the inositol monophosphatase family. It has been proposed that CysQ helps control intracellular levels of PAPS, which is an intermediate in...; Region: CysQ; cd01638 1310161002296 active site 1310161002297 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 1310161002298 putative ATP-dependent helicase Lhr; Provisional; Region: PRK09751 1310161002299 ATP binding site [chemical binding]; other site 1310161002300 putative Mg++ binding site [ion binding]; other site 1310161002301 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 1310161002302 nucleotide binding region [chemical binding]; other site 1310161002303 ATP-binding site [chemical binding]; other site 1310161002304 DEAD/H associated; Region: DEAD_assoc; pfam08494 1310161002305 Formamidopyrimidine-DNA glycosylase [DNA replication, recombination, and repair]; Region: Nei; COG0266 1310161002306 N-terminal domain of the actinomycetal Nei2 and related DNA glycosylases; Region: AcNei2_N; cd08971 1310161002307 putative DNA binding site [nucleotide binding]; other site 1310161002308 catalytic residue [active] 1310161002309 putative H2TH interface [polypeptide binding]; other site 1310161002310 putative catalytic residues [active] 1310161002311 Formamidopyrimidine-DNA glycosylase H2TH domain; Region: H2TH; pfam06831 1310161002312 Zinc finger found in FPG and IleRS; Region: zf-FPG_IleRS; pfam06827 1310161002313 Predicted membrane protein [Function unknown]; Region: COG3304 1310161002314 Domain of unknown function (DUF307); Region: DUF307; pfam03733 1310161002315 Domain of unknown function (DUF307); Region: DUF307; pfam03733 1310161002316 Uncharacterized membrane-associated protein [Function unknown]; Region: DedA; COG0586 1310161002317 SNARE associated Golgi protein; Region: SNARE_assoc; pfam09335 1310161002318 Cyanate permease [Inorganic ion transport and metabolism]; Region: CynX; COG2807 1310161002319 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1310161002320 putative substrate translocation pore; other site 1310161002321 glucose-6-phosphate isomerase; Reviewed; Region: pgi; PRK00179 1310161002322 Phosphoglucose isomerase (PGI) contains two SIS (Sugar ISomerase) domains. This classification is based on the alignment of the first SIS domain. PGI is a multifunctional enzyme which as an intracellular dimer catalyzes the reversible isomerization of...; Region: SIS_PGI_1; cd05015 1310161002323 active site 1310161002324 dimer interface [polypeptide binding]; other site 1310161002325 Phosphoglucose isomerase (PGI) contains two SIS (Sugar ISomerase) domains. This classification is based on the alignment of the second SIS domain. PGI is a multifunctional enzyme which as an intracellular dimer catalyzes the reversible isomerization of...; Region: SIS_PGI_2; cd05016 1310161002326 dimer interface [polypeptide binding]; other site 1310161002327 active site 1310161002328 HNH nucleases; HNH endonuclease signature which is found in viral, prokaryotic, and eukaryotic proteins. The alignment includes members of the large group of homing endonucleases, yeast intron 1 protein, MutS, as well as bacterial colicins, pyocins, and...; Region: HNHc; cd00085 1310161002329 active site 1310161002330 hypothetical protein; Provisional; Region: PRK07857 1310161002331 ATP-dependent DNA helicase PcrA; Region: pcrA; TIGR01073 1310161002332 Part of AAA domain; Region: AAA_19; pfam13245 1310161002333 Family description; Region: UvrD_C_2; pfam13538 1310161002334 FtsX-like permease family; Region: FtsX; pfam02687 1310161002335 ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136 1310161002336 ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255 1310161002337 Walker A/P-loop; other site 1310161002338 ATP binding site [chemical binding]; other site 1310161002339 Q-loop/lid; other site 1310161002340 ABC transporter signature motif; other site 1310161002341 Walker B; other site 1310161002342 D-loop; other site 1310161002343 H-loop/switch region; other site 1310161002344 Predicted transcriptional regulators [Transcription]; Region: COG1695 1310161002345 Transcriptional regulator PadR-like family; Region: PadR; cl17335 1310161002346 Membrane proteins related to metalloendopeptidases [Cell envelope biogenesis, outer membrane]; Region: NlpD; COG0739 1310161002347 Peptidase family M23; Region: Peptidase_M23; pfam01551 1310161002348 phosphoribosylglycinamide formyltransferase; Reviewed; Region: purN; PRK05647 1310161002349 Phosphoribosylglycinamide formyltransferase (GAR transformylase, GART); Region: FMT_core_GART; cd08645 1310161002350 active site 1310161002351 substrate binding site [chemical binding]; other site 1310161002352 cosubstrate binding site; other site 1310161002353 catalytic site [active] 1310161002354 bifunctional phosphoribosylaminoimidazolecarboxamide formyltransferase/IMP cyclohydrolase; Provisional; Region: purH; PRK00881 1310161002355 Inosine monophosphate cyclohydrolase domain. This is the N-terminal domain in the purine biosynthesis pathway protein ATIC (purH). The bifunctional ATIC protein contains a C-terminal ATIC formylase domain that formylates...; Region: IMPCH; cd01421 1310161002356 purine monophosphate binding site [chemical binding]; other site 1310161002357 dimer interface [polypeptide binding]; other site 1310161002358 putative catalytic residues [active] 1310161002359 AICARFT/IMPCHase bienzyme; Region: AICARFT_IMPCHas; smart00798 1310161002360 AICARFT/IMPCHase bienzyme; Region: AICARFT_IMPCHas; cl03362 1310161002361 Citrate lyase beta subunit [Carbohydrate transport and metabolism]; Region: CitE; COG2301 1310161002362 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 1310161002363 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 1310161002364 30S ribosomal protein S18; Provisional; Region: PRK13401 1310161002365 30S ribosomal protein S14; Reviewed; Region: rpsN; PRK08881 1310161002366 50S ribosomal protein L33; Validated; Region: rpmG; PRK00595 1310161002367 50S ribosomal protein L28; Reviewed; Region: rpmB; PRK00359 1310161002368 Sulfate permease and related transporters (MFS superfamily) [Inorganic ion transport and metabolism]; Region: SUL1; COG0659 1310161002369 Sulfate transporter N-terminal domain with GLY motif; Region: Sulfate_tra_GLY; pfam13792 1310161002370 Sulfate transporter family; Region: Sulfate_transp; pfam00916 1310161002371 Sulphate Transporter and Anti-Sigma factor antagonist domain of SulP-like sulfate transporters, plays a role in the function and regulation of the transport activity, proposed general NTP binding function; Region: STAS_SulP_like_sulfate_transporter; cd07042 1310161002372 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 1310161002373 dimerization interface [polypeptide binding]; other site 1310161002374 putative DNA binding site [nucleotide binding]; other site 1310161002375 putative Zn2+ binding site [ion binding]; other site 1310161002376 50S ribosomal protein L31 type B; Reviewed; Region: rpmE2; PRK01678 1310161002377 Ribosomal L32p protein family; Region: Ribosomal_L32p; cl09115 1310161002378 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 1310161002379 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1310161002380 active site 1310161002381 phosphorylation site [posttranslational modification] 1310161002382 intermolecular recognition site; other site 1310161002383 dimerization interface [polypeptide binding]; other site 1310161002384 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 1310161002385 DNA binding site [nucleotide binding] 1310161002386 heavy metal sensor kinase; Region: cztS_silS_copS; TIGR01386 1310161002387 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 1310161002388 dimerization interface [polypeptide binding]; other site 1310161002389 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 1310161002390 dimer interface [polypeptide binding]; other site 1310161002391 phosphorylation site [posttranslational modification] 1310161002392 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1310161002393 ATP binding site [chemical binding]; other site 1310161002394 Mg2+ binding site [ion binding]; other site 1310161002395 G-X-G motif; other site 1310161002396 Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain [Posttranslational modification, protein turnover, chaperones]; Region: DegQ; COG0265 1310161002397 Trypsin-like peptidase domain; Region: Trypsin_2; pfam13365 1310161002398 PDZ domain of tryspin-like serine proteases, such as DegP/HtrA, which are oligomeric proteins involved in heat-shock response, chaperone function, and apoptosis. May be responsible for substrate recognition and/or binding, as most PDZ domains bind...; Region: PDZ_serine_protease; cd00987 1310161002399 protein binding site [polypeptide binding]; other site 1310161002400 MogA_MoaB family. Members of this family are involved in biosynthesis of the molybdenum cofactor (MoCF) an essential cofactor of a diverse group of redox enzymes. MoCF biosynthesis is an evolutionarily conserved pathway present in eubacteria, archaea; Region: MogA_MoaB; cd00886 1310161002401 MPT binding site; other site 1310161002402 trimer interface [polypeptide binding]; other site 1310161002403 ADDz for ATRX, Dnmt3 and Dnmt3l PHD-like zinc finger domain; Region: ADDz; cl17040 1310161002404 large-conductance mechanosensitive channel; Reviewed; Region: mscL; PRK00567 1310161002405 Large-conductance mechanosensitive channel [Cell envelope biogenesis, outer membrane]; Region: MscL; COG1970 1310161002406 SAF domains of the flagella basal body P-ring formation protein FlgA and the flp pilus assembly CpaB; Region: SAF_CpaB_FlgA_like; cd11614 1310161002407 5-formyltetrahydrofolate cyclo-ligase family; Region: 5-FTHF_cyc-lig; pfam01812 1310161002408 5,10-methenyltetrahydrofolate synthetase; Region: MTHFS_bact; TIGR02727 1310161002409 Prokaryotic UGPase catalyses the synthesis of UDP-glucose; Region: UGPase_prokaryotic; cd02541 1310161002410 dTDP-glucose pyrophosphorylase [Cell envelope biogenesis, outer membrane]; Region: RfbA; COG1209 1310161002411 active site 1310161002412 tetramer interface; other site 1310161002413 Molybdopterin biosynthesis enzyme [Coenzyme metabolism]; Region: MoeA; COG0303 1310161002414 MoeA family. Members of this family are involved in biosynthesis of the molybdenum cofactor (MoCF), an essential cofactor of a diverse group of redox enzymes. MoCF biosynthesis is an evolutionarily conserved pathway present in eubacteria, archaea and...; Region: MoeA; cd00887 1310161002415 dimer interface [polypeptide binding]; other site 1310161002416 putative functional site; other site 1310161002417 putative MPT binding site; other site 1310161002418 Acetyltransferases, including N-acetylases of ribosomal proteins [Translation, ribosomal structure and biogenesis]; Region: RimL; COG1670 1310161002419 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl17182 1310161002420 Cyanate permease [Inorganic ion transport and metabolism]; Region: CynX; COG2807 1310161002421 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1310161002422 putative substrate translocation pore; other site 1310161002423 Predicted membrane protein [Function unknown]; Region: COG2259 1310161002424 Predicted integral membrane protein [Function unknown]; Region: COG5660 1310161002425 Putative zinc-finger; Region: zf-HC2; pfam13490 1310161002426 Alpha amylase catalytic domain found in bacterial cyclomaltodextrinases and related proteins; Region: AmyAc_bac_CMD_like; cd11354 1310161002427 Glycosidases [Carbohydrate transport and metabolism]; Region: AmyA; COG0366 1310161002428 active site 1310161002429 catalytic site [active] 1310161002430 Dolichyl-phosphate-mannose--protein O-mannosyl transferase [Posttranslational modification, protein turnover, chaperones]; Region: PMT1; COG1928 1310161002431 Dolichyl-phosphate-mannose-protein mannosyltransferase; Region: PMT_2; cl17364 1310161002432 Predicted methyltransferases [General function prediction only]; Region: COG0313 1310161002433 Ribosomal RNA small subunit methyltransferase I, also known as rRNA (cytidine-2'-O-)-methyltransferase RsmI; Region: RsmI; cd11648 1310161002434 putative SAM binding site [chemical binding]; other site 1310161002435 putative homodimer interface [polypeptide binding]; other site 1310161002438 methionyl-tRNA synthetase; Reviewed; Region: PRK12268 1310161002439 catalytic core domain of methioninyl-tRNA synthetases; Region: MetRS_core; cd00814 1310161002440 active site 1310161002441 HIGH motif; other site 1310161002442 KMSKS motif; other site 1310161002443 Anticodon-binding domain of methionyl tRNA synthetases; Region: Anticodon_Ia_Met; cd07957 1310161002444 tRNA binding surface [nucleotide binding]; other site 1310161002445 anticodon binding site; other site 1310161002446 Superfamily II DNA helicase [DNA replication, recombination, and repair]; Region: RecQ; COG0514 1310161002447 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 1310161002448 ATP binding site [chemical binding]; other site 1310161002449 putative Mg++ binding site [ion binding]; other site 1310161002450 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 1310161002451 nucleotide binding region [chemical binding]; other site 1310161002452 ATP-binding site [chemical binding]; other site 1310161002453 Kynurenine formamidase [Amino acid transport and metabolism]; Region: COG1878 1310161002454 Uncharacterized conserved protein, contains double-stranded beta-helix domain [Function unknown]; Region: COG1917 1310161002455 Prolyl oligopeptidase family; Region: Peptidase_S9; pfam00326 1310161002456 HTH-like domain; Region: HTH_21; pfam13276 1310161002457 Integrase core domain; Region: rve; pfam00665 1310161002458 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3464 1310161002459 Transposase; Region: DDE_Tnp_ISL3; pfam01610 1310161002460 D-lactate dehydrogenase; Provisional; Region: PRK11183 1310161002461 FAD binding domain; Region: FAD_binding_4; pfam01565 1310161002462 D-lactate dehydrogenase, membrane binding; Region: Lact-deh-memb; pfam09330 1310161002463 Adenine specific DNA methylase Mod [DNA replication, recombination, and repair]; Region: COG2189 1310161002464 DNA methylase; Region: N6_N4_Mtase; pfam01555 1310161002465 HTH-like domain; Region: HTH_21; pfam13276 1310161002466 Integrase core domain; Region: rve; pfam00665 1310161002467 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 1310161002468 dimerization interface [polypeptide binding]; other site 1310161002469 putative DNA binding site [nucleotide binding]; other site 1310161002470 putative Zn2+ binding site [ion binding]; other site 1310161002471 Predicted permease, cadmium resistance protein [Inorganic ion transport and metabolism]; Region: CadD; COG4300 1310161002472 Cadmium resistance transporter; Region: Cad; pfam03596 1310161002473 TatD like proteins; E.coli TatD is a cytoplasmic protein, shown to have magnesium dependent DNase activity; Region: TatD_DNAse; cd01310 1310161002474 active site 1310161002475 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3583 1310161002476 Domain of unknown function (DUF348); Region: DUF348; pfam03990 1310161002477 Domain of unknown function (DUF348); Region: DUF348; pfam03990 1310161002478 G5 domain; Region: G5; pfam07501 1310161002479 Transglycosylase-like domain; Region: Transglycosylas; pfam06737 1310161002480 16S ribosomal RNA methyltransferase KsgA/Dim1 family protein; Reviewed; Region: ksgA; PRK00274 1310161002481 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 1310161002482 S-adenosylmethionine binding site [chemical binding]; other site 1310161002483 4-diphosphocytidyl-2-C-methyl-D-erythritol kinase; Provisional; Region: PRK03188 1310161002484 GHMP kinases C terminal; Region: GHMP_kinases_C; pfam08544 1310161002485 ATPase components of ABC transporters with duplicated ATPase domains [General function prediction only]; Region: Uup; COG0488 1310161002486 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 1310161002487 ABC transporter; Region: ABC_tran_2; pfam12848 1310161002488 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 1310161002489 Pyridoxal kinase plays a key role in the synthesis of the active coenzyme pyridoxal-5'-phosphate (PLP), by catalyzing the phosphorylation of the precursor vitamin B6 in the presence of Zn2+ and ATP. Mammals are unable to synthesize PLP de novo and...; Region: pyridoxal_pyridoxamine_kinase; cd01173 1310161002490 dimer interface [polypeptide binding]; other site 1310161002491 pyridoxal binding site [chemical binding]; other site 1310161002492 ATP binding site [chemical binding]; other site 1310161002493 TlpA-like family; composed of TlpA, ResA, DsbE and similar proteins. TlpA, ResA and DsbE are bacterial protein disulfide reductases with important roles in cytochrome maturation. They are membrane-anchored proteins with a soluble TRX domain containing a...; Region: TlpA_like_family; cd02966 1310161002494 Thioredoxin-like; Region: Thioredoxin_8; pfam13905 1310161002495 catalytic residues [active] 1310161002496 Uncharacterized conserved protein [Function unknown]; Region: COG1359 1310161002497 Uncharacterized conserved protein [Function unknown]; Region: COG1359 1310161002498 polyphosphate kinase 2, PA0141 family; Region: PPK2_P_aer; TIGR03707 1310161002499 Predicted hydrolases of the HAD superfamily [General function prediction only]; Region: Cof; COG0561 1310161002500 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 1310161002501 active site 1310161002502 motif I; other site 1310161002503 motif II; other site 1310161002504 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 1310161002505 3-hydroxyisobutyryl-CoA hydrolase; Provisional; Region: PRK05617 1310161002506 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 1310161002507 substrate binding site [chemical binding]; other site 1310161002508 oxyanion hole (OAH) forming residues; other site 1310161002509 trimer interface [polypeptide binding]; other site 1310161002510 2-enoyl-CoA Hydratase C-terminal region; Region: ECH_C; pfam13766 1310161002511 Predicted membrane protein [General function prediction only]; Region: COG4194 1310161002512 Predicted esterase [General function prediction only]; Region: COG0627 1310161002513 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 1310161002514 Predicted drug exporters of the RND superfamily [General function prediction only]; Region: COG2409 1310161002515 ribonuclease activity regulator protein RraA; Provisional; Region: PRK09372 1310161002516 Uncharacterized protein conserved in bacteria (DUF2199); Region: DUF2199; cl02048 1310161002517 Domain of unknown function (DUF222); Region: DUF222; pfam02720 1310161002518 HNH nucleases; HNH endonuclease signature which is found in viral, prokaryotic, and eukaryotic proteins. The alignment includes members of the large group of homing endonucleases, yeast intron 1 protein, MutS, as well as bacterial colicins, pyocins, and...; Region: HNHc; cd00085 1310161002519 active site 1310161002520 Peptide chain release factor RF-3 [Translation, ribosomal structure and biogenesis]; Region: PrfC; COG4108 1310161002521 Release Factor 3 (RF3) protein involved in the terminal step of translocation in bacteria; Region: RF3; cd04169 1310161002522 G1 box; other site 1310161002523 putative GEF interaction site [polypeptide binding]; other site 1310161002524 GTP/Mg2+ binding site [chemical binding]; other site 1310161002525 Switch I region; other site 1310161002526 G2 box; other site 1310161002527 G3 box; other site 1310161002528 Switch II region; other site 1310161002529 G4 box; other site 1310161002530 G5 box; other site 1310161002531 Translation_Factor_II_like: Elongation factor Tu (EF-Tu) domain II-like proteins. Elongation factor Tu consists of three structural domains, this family represents the second domain. Domain II adopts a beta barrel structure and is involved in binding to...; Region: Translation_Factor_II_like; cl02787 1310161002532 Periplasmic binding protein; Region: Peripla_BP_6; pfam13458 1310161002533 Periplasmic component (FmdD) of an active transport system for short-chain amides and urea (FmdDEF); Region: PBP1_FmdD_like; cd06355 1310161002534 putative ligand binding site [chemical binding]; other site 1310161002535 Transmembrane subunit (TM) of Escherichia coli LivH and related proteins. LivH is one of two TMs of the E. coli LIV-1/LS transporter, a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of...; Region: TM_PBP1_LivH_like; cd06582 1310161002536 Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653 1310161002537 TM-ABC transporter signature motif; other site 1310161002538 ABC-type branched-chain amino acid transport system, permease component [Amino acid transport and metabolism]; Region: LivM; COG4177 1310161002539 Transmembrane subunit (TM) of Escherichia coli LivM and related proteins. LivM is one of two TMs of the E. coli LIV-1/LS transporter, a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of...; Region: TM_PBP1_LivM_like; cd06581 1310161002540 TM-ABC transporter signature motif; other site 1310161002541 Uncharacterized ABC-type transport system, ATPase component [General function prediction only]; Region: COG4674 1310161002542 ATP-binding cassette component of branched chain amino acids transport system; Region: ABC_Mj1267_LivG_branched; cd03219 1310161002543 Walker A/P-loop; other site 1310161002544 ATP binding site [chemical binding]; other site 1310161002545 Q-loop/lid; other site 1310161002546 ABC transporter signature motif; other site 1310161002547 Walker B; other site 1310161002548 D-loop; other site 1310161002549 H-loop/switch region; other site 1310161002550 urea ABC transporter, ATP-binding protein UrtE; Region: urea_trans_UrtE; TIGR03410 1310161002551 ATP-binding cassette domain of branched-chain amino acid transporter; Region: ABC_TM1139_LivF_branched; cd03224 1310161002552 Walker A/P-loop; other site 1310161002553 ATP binding site [chemical binding]; other site 1310161002554 Q-loop/lid; other site 1310161002555 ABC transporter signature motif; other site 1310161002556 Walker B; other site 1310161002557 D-loop; other site 1310161002558 H-loop/switch region; other site 1310161002559 Peptidyl-tRNA hydrolase (PTH) is a monomeric protein that cleaves the ester bond linking the nascent peptide and tRNA when peptidyl-tRNA is released prematurely from the ribosome. This ensures the recycling of peptidyl-tRNAs into tRNAs produced through...; Region: PTH; cd00462 1310161002560 putative active site [active] 1310161002561 catalytic residue [active] 1310161002562 Dioxygenases related to 2-nitropropane dioxygenase [General function prediction only]; Region: COG2070 1310161002563 2-Nitropropane dioxygenase (NPD), one of the nitroalkane oxidizing enzyme families, catalyzes oxidative denitrification of nitroalkanes to their corresponding carbonyl compounds and nitrites. NDP is a member of the NAD(P)H-dependent flavin oxidoreductase...; Region: NPD_like; cd04730 1310161002564 FMN binding site [chemical binding]; other site 1310161002565 substrate binding site [chemical binding]; other site 1310161002566 putative catalytic residue [active] 1310161002567 glyceraldehyde-3-phosphate dehydrogenase; Reviewed; Region: PRK08289 1310161002568 Glyceraldehyde 3-phosphate dehydrogenase, NAD binding domain; Region: Gp_dh_N; smart00846 1310161002569 Glyceraldehyde 3-phosphate dehydrogenase, C-terminal domain; Region: Gp_dh_C; pfam02800 1310161002570 Peptidyl-tRNA hydrolase (PTH) is a monomeric protein that cleaves the ester bond linking the nascent peptide and tRNA when peptidyl-tRNA is released prematurely from the ribosome. This ensures the recycling of peptidyl-tRNAs into tRNAs produced through...; Region: PTH; cd00462 1310161002571 putative active site [active] 1310161002572 catalytic residue [active] 1310161002573 50S ribosomal protein L25/general stress protein Ctc; Reviewed; Region: PRK05618 1310161002574 Ribosomal L25/TL5/CTC N-terminal 5S rRNA binding domain; Region: Ribosomal_L25_TL5_CTC; cd00495 1310161002575 5S rRNA interface [nucleotide binding]; other site 1310161002576 CTC domain interface [polypeptide binding]; other site 1310161002577 L16 interface [polypeptide binding]; other site 1310161002578 This conserved domain belongs to a superfamily including the bleomycin resistance protein, glyoxalase I, and type I ring-cleaving dioxygenases; Region: Glo_EDI_BRP_like_24; cd09012 1310161002579 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 1310161002580 DNA alkylation repair enzyme; Region: DNA_alkylation; pfam08713 1310161002581 A new structural DNA glycosylase containing HEAT-like repeats; Region: AlkD_like_1; cd07064 1310161002582 active site 1310161002583 N-terminal domain of ribose phosphate pyrophosphokinase; Region: Pribosyltran_N; pfam13793 1310161002584 ribose-phosphate pyrophosphokinase; Provisional; Region: PRK03092 1310161002585 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 1310161002586 active site 1310161002587 bifunctional N-acetylglucosamine-1-phosphate uridyltransferase/glucosamine-1-phosphate acetyltransferase; Provisional; Region: glmU; PRK14352 1310161002588 N-terminal domain of bacterial GlmU; Region: GT2_GlmU_N_bac; cd02540 1310161002589 Substrate binding site; other site 1310161002590 Mg++ binding site; other site 1310161002591 N-acetyl-glucosamine-1-phosphate uridyltransferase (GlmU), C-terminal left-handed beta-helix (LbH) acetyltransferase domain: GlmU is also known as UDP-N-acetylglucosamine pyrophosphorylase. It is a bifunctional bacterial enzyme that catalyzes two...; Region: LbH_GlmU_C; cd03353 1310161002592 active site 1310161002593 substrate binding site [chemical binding]; other site 1310161002594 CoA binding site [chemical binding]; other site 1310161002595 Major Facilitator Superfamily; Region: MFS_1; pfam07690 1310161002596 Putative multicopper oxidases [Secondary metabolites biosynthesis, transport, and catabolism]; Region: SufI; COG2132 1310161002597 Multicopper oxidase; Region: Cu-oxidase_3; pfam07732 1310161002598 Multicopper oxidase; Region: Cu-oxidase_2; pfam07731 1310161002599 ABC-type multidrug transport system, ATPase component [Defense mechanisms]; Region: CcmA; COG1131 1310161002600 ATP-binding cassette domain of the drug resistance transporter and related proteins, subfamily A; Region: ABC_DR_subfamily_A; cd03230 1310161002601 Walker A/P-loop; other site 1310161002602 ATP binding site [chemical binding]; other site 1310161002603 Q-loop/lid; other site 1310161002604 ABC transporter signature motif; other site 1310161002605 Walker B; other site 1310161002606 D-loop; other site 1310161002607 H-loop/switch region; other site 1310161002608 ABC-2 family transporter protein; Region: ABC2_membrane_3; pfam12698 1310161002609 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: COG4585 1310161002610 Histidine kinase; Region: HisKA_3; pfam07730 1310161002611 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 1310161002612 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1310161002613 active site 1310161002614 phosphorylation site [posttranslational modification] 1310161002615 intermolecular recognition site; other site 1310161002616 dimerization interface [polypeptide binding]; other site 1310161002617 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 1310161002618 DNA binding residues [nucleotide binding] 1310161002619 dimerization interface [polypeptide binding]; other site 1310161002620 ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132 1310161002621 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 1310161002622 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 1310161002623 ABC transporter signature motif; other site 1310161002624 Walker B; other site 1310161002625 D-loop; other site 1310161002626 H-loop/switch region; other site 1310161002627 ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132 1310161002628 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 1310161002629 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 1310161002630 Walker A/P-loop; other site 1310161002631 ATP binding site [chemical binding]; other site 1310161002632 Q-loop/lid; other site 1310161002633 ABC transporter signature motif; other site 1310161002634 Walker B; other site 1310161002635 D-loop; other site 1310161002636 H-loop/switch region; other site 1310161002637 Gamma-glutamyltransferase [Amino acid transport and metabolism]; Region: Ggt; COG0405 1310161002638 Gamma-glutamyltranspeptidase; Region: G_glu_transpept; pfam01019 1310161002639 Excalibur calcium-binding domain; Region: Excalibur; pfam05901 1310161002640 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3316 1310161002641 Integrase core domain; Region: rve; pfam00665 1310161002642 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 1310161002643 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 1310161002644 Transcription-repair coupling factor (superfamily II helicase) [DNA replication, recombination, and repair / Transcription]; Region: Mfd; COG1197 1310161002645 CarD-like/TRCF domain; Region: CarD_TRCF; smart01058 1310161002646 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 1310161002647 ATP binding site [chemical binding]; other site 1310161002648 putative Mg++ binding site [ion binding]; other site 1310161002649 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 1310161002650 nucleotide binding region [chemical binding]; other site 1310161002651 ATP-binding site [chemical binding]; other site 1310161002652 This domain is found in proteins necessary for strand-specific repair in DNA such as TRCF in Escherichia coli; Region: TRCF; smart00982 1310161002653 ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132 1310161002654 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 1310161002655 ATP-binding cassette domain of glucan transporter and related proteins, subfamily C; Region: ABCC_Glucan_exporter_like; cd03254 1310161002656 Walker A/P-loop; other site 1310161002657 ATP binding site [chemical binding]; other site 1310161002658 Q-loop/lid; other site 1310161002659 ABC transporter signature motif; other site 1310161002660 Walker B; other site 1310161002661 D-loop; other site 1310161002662 H-loop/switch region; other site 1310161002663 ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132 1310161002664 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 1310161002665 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 1310161002666 Walker A/P-loop; other site 1310161002667 ATP binding site [chemical binding]; other site 1310161002668 Q-loop/lid; other site 1310161002669 ABC transporter signature motif; other site 1310161002670 Walker B; other site 1310161002671 D-loop; other site 1310161002672 H-loop/switch region; other site 1310161002673 Uncharacterized conserved protein [Function unknown]; Region: COG2898 1310161002674 Uncharacterized conserved protein (DUF2156); Region: DUF2156; pfam09924 1310161002675 Predicted esterase [General function prediction only]; Region: COG0627 1310161002676 transporter, basic amino acid/polyamine antiporter (APA) family; Region: 2A0302; TIGR00905 1310161002677 MT0933-like antitoxin protein; Region: MT0933_antitox; pfam14013 1310161002678 Nucleoside Triphosphate Pyrophosphohydrolase (EC 3.6.1.8) N-terminal tandem-domain of MazG proteins from Escherichia coli and bacterial homologs; Region: NTP-PPase_MazG_Nterm; cd11528 1310161002679 homodimer interface [polypeptide binding]; other site 1310161002680 metal binding site [ion binding]; metal-binding site 1310161002681 Alpha helical Porin B; Region: PorB; pfam11565 1310161002682 Alpha helical Porin B; Region: PorB; pfam11565 1310161002683 Membrane-bound lytic murein transglycosylase B [Cell envelope biogenesis, outer membrane]; Region: MltB; COG2951 1310161002684 Lytic Transglycosylase (LT) and Goose Egg White Lysozyme (GEWL) domain. Members include the soluble and insoluble membrane-bound LTs in bacteria, the LTs in bacteriophage lambda, as well as, the eukaryotic "goose-type" lysozymes (GEWL). LTs...; Region: LT_GEWL; cd00254 1310161002685 N-acetyl-D-glucosamine binding site [chemical binding]; other site 1310161002686 enolase; Provisional; Region: eno; PRK00077 1310161002687 Enolase: Enolases are homodimeric enzymes that catalyse the reversible dehydration of 2-phospho-D-glycerate to phosphoenolpyruvate as part of the glycolytic and gluconeogenesis pathways. The reaction is facilitated by the presence of metal ions; Region: enolase; cd03313 1310161002688 dimer interface [polypeptide binding]; other site 1310161002689 metal binding site [ion binding]; metal-binding site 1310161002690 substrate binding pocket [chemical binding]; other site 1310161002691 Septum formation initiator; Region: DivIC; pfam04977 1310161002692 Septum formation initiator [Cell division and chromosome partitioning]; Region: COG2919 1310161002693 Uncharacterized conserved protein [Function unknown]; Region: COG1507 1310161002694 exopolyphosphatase; Region: exo_poly_only; TIGR03706 1310161002695 Ppx/GppA phosphatase family; Region: Ppx-GppA; pfam02541 1310161002696 Threonine dehydratase [Amino acid transport and metabolism]; Region: IlvA; COG1171 1310161002697 Threonine dehydratase: The first step in amino acid degradation is the removal of nitrogen. Although the nitrogen atoms of most amino acids are transferred to alpha-ketoglutarate before removal, the alpha-amino group of threonine can be directly...; Region: Thr-dehyd; cd01562 1310161002698 tetramer interface [polypeptide binding]; other site 1310161002699 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1310161002700 catalytic residue [active] 1310161002701 Pyrimidine reductase, riboflavin biosynthesis [Coenzyme metabolism]; Region: RibD; COG1985 1310161002702 RibD C-terminal domain; Region: RibD_C; cl17279 1310161002703 Putative stress-responsive transcriptional regulator [Transcription / Signal transduction mechanisms]; Region: PspC; COG1983 1310161002704 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 1310161002705 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 1310161002706 Predicted membrane protein [Function unknown]; Region: COG4760 1310161002707 transcription elongation factor GreA; Reviewed; Region: greA; PRK00226 1310161002708 Transcription elongation factor, N-terminal; Region: GreA_GreB_N; pfam03449 1310161002709 Transcription elongation factor, GreA/GreB, C-term; Region: GreA_GreB; pfam01272 1310161002710 Domain of unknown function (DUF4307); Region: DUF4307; pfam14155 1310161002711 mycothiol conjugate amidase Mca; Region: mycothiol_Mca; TIGR03446 1310161002712 phospho-2-dehydro-3-deoxyheptonate aldolase; Validated; Region: PRK09261 1310161002713 DAHP synthetase I family; Region: DAHP_synth_1; pfam00793 1310161002714 undecaprenyl pyrophosphate synthase; Provisional; Region: PRK14828 1310161002715 Undecaprenyl pyrophosphate synthase [Lipid metabolism]; Region: UppS; COG0020 1310161002716 catalytic residue [active] 1310161002717 putative FPP diphosphate binding site; other site 1310161002718 putative FPP binding hydrophobic cleft; other site 1310161002719 dimer interface [polypeptide binding]; other site 1310161002720 putative IPP diphosphate binding site; other site 1310161002721 Flavodoxin domain; Region: Flavodoxin_5; pfam12724 1310161002722 pantothenate kinase; Provisional; Region: PRK05439 1310161002723 Pantothenate kinase (PanK) catalyzes the phosphorylation of pantothenic acid to form 4'-phosphopantothenic, which is the first of five steps in coenzyme A (CoA) biosynthetic pathway. The reaction carried out by this enzyme is a key regulatory point...; Region: PanK; cd02025 1310161002724 ATP-binding site [chemical binding]; other site 1310161002725 CoA-binding site [chemical binding]; other site 1310161002726 Mg2+-binding site [ion binding]; other site 1310161002727 serine hydroxymethyltransferase; Reviewed; Region: glyA; PRK00011 1310161002728 Serine-glycine hydroxymethyltransferase (SHMT). This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). SHMT carries out interconversion of serine and glycine; it catalyzes the transfer of hydroxymethyl...; Region: SHMT; cd00378 1310161002729 dimer interface [polypeptide binding]; other site 1310161002730 active site 1310161002731 glycine-pyridoxal phosphate binding site [chemical binding]; other site 1310161002732 folate binding site [chemical binding]; other site 1310161002733 Type 1 glutamine amidotransferase (GATase1) domain found in Anthranilate synthase; Region: GATase1_Anthranilate_Synthase; cd01743 1310161002734 Glutamine amidotransferase class-I; Region: GATase; pfam00117 1310161002735 glutamine binding [chemical binding]; other site 1310161002736 catalytic triad [active] 1310161002737 Anthranilate synthase component I, N terminal region; Region: Anth_synt_I_N; pfam04715 1310161002738 aminodeoxychorismate synthase, component I, clade 2; Region: PabB-clade2; TIGR01824 1310161002739 chorismate binding enzyme; Region: Chorismate_bind; cl10555 1310161002740 Branched-chain amino acid aminotransferase/4-amino-4-deoxychorismate lyase [Amino acid transport and metabolism / Coenzyme metabolism]; Region: IlvE; COG0115 1310161002741 substrate-cofactor binding pocket; other site 1310161002742 homodimer interface [polypeptide binding]; other site 1310161002743 Aminotransferase class IV; Region: Aminotran_4; pfam01063 1310161002744 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1310161002745 catalytic residue [active] 1310161002746 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 1310161002747 Sortase and related acyltransferases [Cell envelope biogenesis, outer membrane]; Region: COG1247 1310161002748 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 1310161002749 Coenzyme A binding pocket [chemical binding]; other site 1310161002750 Allophanate hydrolase subunit 2 [Amino acid transport and metabolism]; Region: DUR1; COG1984 1310161002751 Allophanate hydrolase subunit 1; Region: AHS1; smart00796 1310161002752 Allophanate hydrolase subunit 1 [Amino acid transport and metabolism]; Region: DUR1; COG2049 1310161002753 LamB/YcsF family of lactam utilization protein; Region: LamB_YcsF_like; cd10787 1310161002754 putative active site [active] 1310161002755 Mn2+ and Fe2+ transporters of the NRAMP family [Inorganic ion transport and metabolism]; Region: MntH; COG1914 1310161002756 Transcriptional regulators [Transcription]; Region: FadR; COG2186 1310161002757 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 1310161002758 DNA-binding site [nucleotide binding]; DNA binding site 1310161002759 FCD domain; Region: FCD; pfam07729 1310161002760 fumarate hydratase; Reviewed; Region: fumC; PRK00485 1310161002761 Class II fumarases; Region: Fumarase_classII; cd01362 1310161002762 active site 1310161002763 tetramer interface [polypeptide binding]; other site 1310161002764 Conserved protein/domain typically associated with flavoprotein oxygenases, DIM6/NTAB family [General function prediction only]; Region: COG1853 1310161002765 Predicted flavoprotein [General function prediction only]; Region: COG0431 1310161002766 NADPH-dependent FMN reductase; Region: FMN_red; pfam03358 1310161002767 FMN-dependent oxidoreductase, nitrilotriacetate monooxygenase family; Region: FMN_nitrolo; TIGR03860 1310161002768 nitrilotriacetate monoxygenase oxidizes nitrilotriacetate utilizing reduced flavin mononucleotide (FMNH2) and oxygen. The FMNH2 is provided by an NADH:flavin mononucleotide (FMN) oxidorductase that uses NADH to reduce FMN to FMNH2; Region: Nitrilotriacetate_monoxgenase; cd01095 1310161002769 active site 1310161002770 non-prolyl cis peptide bond; other site 1310161002771 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 1310161002772 active site 1310161002773 Dibenzothiophene (DBT) desulfurization enzyme C; Region: DszC; cd01163 1310161002774 sulfur acquisition oxidoreductase, SfnB family; Region: sulfur_SfnB; TIGR04022 1310161002775 Flavin binding site [chemical binding]; other site 1310161002776 alkanesulfonate monooxygenase, FMNH(2)-dependent; Region: alk_sulf_monoox; TIGR03565 1310161002777 Alkanesulfonate monoxygenase is the monoxygenase of a two-component system that catalyzes the conversion of alkanesulfonates to the corresponding aldehyde and sulfite. Alkanesulfonate monoxygenase (SsuD) has an absolute requirement for reduced flavin...; Region: Alkanesulfonate_monoxygenase; cd01094 1310161002778 active site 1310161002779 dimer interface [polypeptide binding]; other site 1310161002780 non-prolyl cis peptide bond; other site 1310161002781 insertion regions; other site 1310161002782 Bacterial fructose-1,6-bisphosphatase, glpX-encoded. A dimeric enzyme dependent on Mg(2+). glpX-encoded FPBase (FBPase class II) differs from other members of the inositol-phosphatase superfamily by permutation of secondary structure elements. The core...; Region: FBPase_glpX; cd01516 1310161002783 Bacterial fructose-1,6-bisphosphatase, glpX-encoded; Region: FBPase_glpX; pfam03320 1310161002784 putative active site [active] 1310161002785 Protein of unknown function (DUF4245); Region: DUF4245; pfam14030 1310161002786 VWA ywmD type:Von Willebrand factor type A (vWA) domain was originally found in the blood coagulation protein von Willebrand factor (vWF). Typically, the vWA domain is made up of approximately 200 amino acid residues folded into a classic a/b...; Region: vWA_ywmD_type; cd01456 1310161002787 metal ion-dependent adhesion site (MIDAS); other site 1310161002788 Uncharacterized protein containing a von Willebrand factor type A (vWA) domain [General function prediction only]; Region: COG2304 1310161002789 Arabinose efflux permease [Carbohydrate transport and metabolism]; Region: AraJ; COG2814 1310161002790 exodeoxyribonuclease VII small subunit; Provisional; Region: PRK00977 1310161002791 exodeoxyribonuclease VII large subunit; Reviewed; Region: xseA; PRK00286 1310161002792 ExoVII_LU_OBF: A subfamily of OB folds corresponding to the N-terminal OB-fold domain of Escherichia coli exodeoxyribonuclease VII (ExoVII) large subunit. E. coli ExoVII is composed of two non-identical subunits. E. coli ExoVII is a...; Region: ExoVII_LU_OBF; cd04489 1310161002793 generic binding surface II; other site 1310161002794 generic binding surface I; other site 1310161002795 4-hydroxy-3-methylbut-2-enyl diphosphate reductase; Reviewed; Region: ispH; PRK01045 1310161002796 4-Hydroxy-3-methylbut-2-enyl diphosphate reductase IspH [Lipid metabolism]; Region: lytB; COG0761 1310161002797 Gamma-aminobutyrate permease and related permeases [Amino acid transport and metabolism]; Region: AnsP; COG1113 1310161002798 Membrane protein of unknown function; Region: DUF360; pfam04020 1310161002799 Predicted permease, member of the PurR regulon [General function prediction only]; Region: yhhT; COG0628 1310161002800 Domain of unknown function DUF20; Region: UPF0118; pfam01594 1310161002801 uncharacterized bacterial and archaeal solute carrier 6 subfamily; solute-binding domain; Region: SLC6sbd_u1; cd10334 1310161002802 Na2 binding site [ion binding]; other site 1310161002803 putative substrate binding site 1 [chemical binding]; other site 1310161002804 Na binding site 1 [ion binding]; other site 1310161002805 putative substrate binding site 2 [chemical binding]; other site 1310161002806 Putative esterase; Region: Esterase; pfam00756 1310161002807 GTP-binding protein YchF; Reviewed; Region: PRK09601 1310161002808 YchF GTPase; Region: YchF; cd01900 1310161002809 G1 box; other site 1310161002810 GTP/Mg2+ binding site [chemical binding]; other site 1310161002811 Switch I region; other site 1310161002812 G2 box; other site 1310161002813 Switch II region; other site 1310161002814 G3 box; other site 1310161002815 G4 box; other site 1310161002816 G5 box; other site 1310161002817 TGS_YchF_C: This subfamily represents TGS domain-containing YchF GTP-binding protein, a universally conserved GTPase whose function is unknown. The N-terminal domain of the YchF protein belongs to the Obg-like family of GTPases, and some members of the...; Region: TGS_YchF_C; cd04867 1310161002818 Plasmid maintenance system killer protein; Region: Plasmid_killer; cl01422 1310161002819 Plasmid maintenance system antidote protein [General function prediction only]; Region: VapI; COG3093 1310161002820 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 1310161002821 non-specific DNA binding site [nucleotide binding]; other site 1310161002822 salt bridge; other site 1310161002823 sequence-specific DNA binding site [nucleotide binding]; other site 1310161002824 Ornithine carbamoyltransferase [Amino acid transport and metabolism]; Region: ArgF; COG0078 1310161002825 Aspartate/ornithine carbamoyltransferase, carbamoyl-P binding domain; Region: OTCace_N; pfam02729 1310161002826 Aspartate/ornithine carbamoyltransferase, Asp/Orn binding domain; Region: OTCace; pfam00185 1310161002827 Acetyltransferase (GNAT) domain; Region: Acetyltransf_3; pfam13302 1310161002828 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl17182 1310161002829 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 1310161002830 active site 1310161002831 Transposase; Region: DEDD_Tnp_IS110; pfam01548 1310161002832 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3547 1310161002833 Transposase IS116/IS110/IS902 family; Region: Transposase_20; pfam02371 1310161002834 MASE1; Region: MASE1; pfam05231 1310161002835 PAS domain S-box; Region: sensory_box; TIGR00229 1310161002836 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 1310161002837 putative active site [active] 1310161002838 heme pocket [chemical binding]; other site 1310161002839 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 1310161002840 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 1310161002841 metal binding site [ion binding]; metal-binding site 1310161002842 active site 1310161002843 I-site; other site 1310161002844 EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2). The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948 1310161002845 Glycosyltransferase like family 2; Region: Glyco_tranf_2_3; pfam13641 1310161002846 CESA_like is the cellulose synthase superfamily; Region: CESA_like; cd06423 1310161002847 DXD motif; other site 1310161002848 NNMT/PNMT/TEMT family; Region: NNMT_PNMT_TEMT; pfam01234 1310161002849 Homoserine dehydrogenase, NAD binding domain; Region: NAD_binding_3; pfam03447 1310161002853 SMI1 / KNR4 family (SUKH-1); Region: SMI1_KNR4; pfam09346 1310161002854 LigT like Phosphoesterase; Region: LigT_PEase; pfam02834 1310161002855 Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248 1310161002856 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 1310161002857 active site 1310161002858 catalytic tetrad [active] 1310161002859 Uncharacterized homolog of gamma-carboxymuconolactone decarboxylase subunit [Function unknown]; Region: COG0599 1310161002860 atypical (a) SDRs, subgroup 5; Region: SDR_a5; cd05243 1310161002861 NADH(P)-binding; Region: NAD_binding_10; pfam13460 1310161002862 NAD(P) binding site [chemical binding]; other site 1310161002863 putative active site [active] 1310161002864 Sulfate transporter N-terminal domain with GLY motif; Region: Sulfate_tra_GLY; pfam13792 1310161002865 Sulfate permease and related transporters (MFS superfamily) [Inorganic ion transport and metabolism]; Region: SUL1; COG0659 1310161002866 Sulfate transporter family; Region: Sulfate_transp; pfam00916 1310161002867 Sulphate Transporter and Anti-Sigma factor antagonist domain of SulP-like sulfate transporters, plays a role in the function and regulation of the transport activity, proposed general NTP binding function; Region: STAS_SulP_like_sulfate_transporter; cd07042 1310161002868 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 1310161002869 Walker A/P-loop; other site 1310161002870 ATP binding site [chemical binding]; other site 1310161002871 Q-loop/lid; other site 1310161002872 AMP-binding domain protein; Validated; Region: PRK08315 1310161002873 Uncharacterized protein with a von Willebrand factor type A (vWA) domain [General function prediction only]; Region: COG4867 1310161002874 Von Willebrand factor type A (vWA) domain was originally found in the blood coagulation protein von Willebrand factor (vWF). Typically, the vWA domain is made up of approximately 200 amino acid residues folded into a classic a/b para-rossmann type of...; Region: vWFA; cd00198 1310161002875 metal ion-dependent adhesion site (MIDAS); other site 1310161002876 conserved hypothetical protein; Region: TIGR03843 1310161002877 Members of the ICL/PEPM enzyme family catalyze either P-C or C-C bond formation/cleavage. Known members are phosphoenolpyruvate mutase (PEPM), phosphonopyruvate hydrolase (PPH), carboxyPEP mutase (CPEP mutase), oxaloacetate hydrolase (OAH), isocitrate...; Region: ICL_PEPM; cd00377 1310161002878 Phosphoenolpyruvate phosphomutase; Region: PEP_mutase; pfam13714 1310161002879 tetramer interface [polypeptide binding]; other site 1310161002880 active site 1310161002881 Mg2+/Mn2+ binding site [ion binding]; other site 1310161002882 ATPase components of ABC transporters with duplicated ATPase domains [General function prediction only]; Region: Uup; COG0488 1310161002883 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 1310161002884 Walker A/P-loop; other site 1310161002885 ATP binding site [chemical binding]; other site 1310161002886 Q-loop/lid; other site 1310161002887 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 1310161002888 ABC transporter; Region: ABC_tran_2; pfam12848 1310161002889 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 1310161002890 Predicted redox protein, regulator of disulfide bond formation [Posttranslational modification, protein turnover, chaperones]; Region: COG1765 1310161002891 Uncharacterized Zn-ribbon-containing protein involved in phosphonate metabolism [Inorganic ion transport and metabolism]; Region: PhnA; COG2824 1310161002892 PhnA Zinc-Ribbon; Region: PhnA_Zn_Ribbon; pfam08274 1310161002893 PhnA protein; Region: PhnA; pfam03831 1310161002894 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 1310161002895 putative DNA binding site [nucleotide binding]; other site 1310161002896 Transcriptional regulators [Transcription]; Region: MarR; COG1846 1310161002897 putative Zn2+ binding site [ion binding]; other site 1310161002898 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1310161002899 Major Facilitator Superfamily; Region: MFS_1; pfam07690 1310161002900 putative substrate translocation pore; other site 1310161002901 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3464 1310161002902 Transposase; Region: DDE_Tnp_ISL3; pfam01610 1310161002903 Cysteine sulfinate desulfinase/cysteine desulfurase and related enzymes [Amino acid transport and metabolism]; Region: NifS; COG1104 1310161002904 cysteine desulfurase NifS; Region: FeS_nifS; TIGR03402 1310161002905 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 1310161002906 catalytic residue [active] 1310161002907 nicotinate-nucleotide pyrophosphorylase; Provisional; Region: PRK06543 1310161002908 Quinolinate phosphoribosyl transferase (QAPRTase or QPRTase), also called nicotinate-nucleotide pyrophosphorylase, is involved in the de novo synthesis of NAD in both prokaryotes and eukaryotes. It catalyses the reaction of quinolinic acid (QA) with...; Region: QPRTase; cd01572 1310161002909 dimerization interface [polypeptide binding]; other site 1310161002910 active site 1310161002911 quinolinate synthetase; Provisional; Region: PRK09375 1310161002912 ADP-ribose pyrophosphatase [Nucleotide transport and metabolism]; Region: COG1051 1310161002913 nudix motif; other site 1310161002914 Uncharacterized conserved protein [General function prediction only]; Region: COG4111 1310161002915 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3238 1310161002916 Protein of unknown function, DUF606; Region: DUF606; pfam04657 1310161002917 Predicted Zn-dependent hydrolases of the beta-lactamase fold [General function prediction only]; Region: COG2220 1310161002918 Metallo-beta-lactamase superfamily; Region: Lactamase_B; cl00446 1310161002919 Uncharacterized protein conserved in bacteria [Function unknown]; Region: MmcQ; COG2315 1310161002920 Lipoate-protein ligase A [Coenzyme metabolism]; Region: LplA; COG0095 1310161002921 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 1310161002922 Escherichia coli PhnB and similar proteins; the E. coli phnB gene is found next to an operon involved in the cleavage of carbon-phosphorus bonds in unactivated alkylphosphonates; Region: PhnB_like; cd06588 1310161002923 dimer interface [polypeptide binding]; other site 1310161002924 benzoate transport; Region: 2A0115; TIGR00895 1310161002925 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1310161002926 putative substrate translocation pore; other site 1310161002927 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1310161002928 4-hydroxybenzoate 3-monooxygenase; Validated; Region: PRK08243 1310161002929 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450 1310161002930 ubiquinone biosynthesis hydroxylase family protein; Provisional; Region: PRK07608; cl17314 1310161002931 ABC-type cobalt transport system, predicted permease component [Inorganic ion transport and metabolism]; Region: COG4721 1310161002932 ABC-type cobalt transport system, ATPase component [Inorganic ion transport and metabolism]; Region: CbiO; COG1122 1310161002933 First domain of the ATP-binding cassette component of cobalt transport system; Region: ABC_cobalt_CbiO_domain1; cd03225 1310161002934 Walker A/P-loop; other site 1310161002935 ATP binding site [chemical binding]; other site 1310161002936 Q-loop/lid; other site 1310161002937 ABC transporter signature motif; other site 1310161002938 Walker B; other site 1310161002939 D-loop; other site 1310161002940 H-loop/switch region; other site 1310161002941 First domain of the ATP-binding cassette component of cobalt transport system; Region: ABC_cobalt_CbiO_domain1; cd03225 1310161002942 cobalt transport protein ATP-binding subunit; Region: cbiO; TIGR01166 1310161002943 Walker A/P-loop; other site 1310161002944 ATP binding site [chemical binding]; other site 1310161002945 Q-loop/lid; other site 1310161002946 ABC transporter signature motif; other site 1310161002947 Walker B; other site 1310161002948 D-loop; other site 1310161002949 H-loop/switch region; other site 1310161002950 ABC-type cobalt transport system, permease component CbiQ and related transporters [Inorganic ion transport and metabolism]; Region: CbiQ; COG0619 1310161002951 hypothetical protein; Provisional; Region: PRK06547 1310161002952 Adenylate kinase and related kinases [Nucleotide transport and metabolism]; Region: Adk; COG0563 1310161002953 Ca2+/H+ antiporter [Inorganic ion transport and metabolism]; Region: ChaA; COG0387 1310161002954 Sodium/calcium exchanger protein; Region: Na_Ca_ex; pfam01699 1310161002955 Uncharacterized proteins, LmbE homologs [Function unknown]; Region: COG2120 1310161002956 Predicted integral membrane protein [Function unknown]; Region: COG5522 1310161002957 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 1310161002958 Walker A/P-loop; other site 1310161002959 ATP binding site [chemical binding]; other site 1310161002960 Q-loop/lid; other site 1310161002961 Excinuclease ATPase subunit [DNA replication, recombination, and repair]; Region: UvrA; COG0178 1310161002962 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 1310161002963 ABC transporter signature motif; other site 1310161002964 Walker B; other site 1310161002965 D-loop; other site 1310161002966 H-loop/switch region; other site 1310161002967 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 1310161002968 Walker A/P-loop; other site 1310161002969 ATP binding site [chemical binding]; other site 1310161002970 Q-loop/lid; other site 1310161002971 ABC transporter signature motif; other site 1310161002972 Walker B; other site 1310161002973 D-loop; other site 1310161002974 H-loop/switch region; other site 1310161002975 Peroxiredoxin (PRX) family, Atypical 2-cys PRX subfamily; composed of PRXs containing peroxidatic and resolving cysteines, similar to the homodimeric thiol specific antioxidant (TSA) protein also known as TRX-dependent thiol peroxidase (Tpx). Tpx is a...; Region: PRX_Atyp2cys; cd03014 1310161002976 dimer interface [polypeptide binding]; other site 1310161002977 catalytic triad [active] 1310161002978 peroxidatic and resolving cysteines [active] 1310161002979 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2354 1310161002980 2-dehydropantoate 2-reductase; Region: apbA_panE; TIGR00745 1310161002981 Ketopantoate reductase PanE/ApbA; Region: ApbA; pfam02558 1310161002982 Ketopantoate reductase PanE/ApbA C terminal; Region: ApbA_C; pfam08546 1310161002983 Uncharacterized protein conserved in bacteria (DUF2218); Region: DUF2218; cl01424 1310161002986 Protein of unknown function (DUF3592); Region: DUF3592; pfam12158 1310161002987 Trypsin; Region: Trypsin; pfam00089 1310161002988 active site 1310161002989 substrate binding sites [chemical binding]; other site 1310161002990 Arsenate Reductase (ArsC) family, ArsC subfamily; arsenic reductases similar to that encoded by arsC on the R733 plasmid of Escherichia coli. E. coli ArsC catalyzes the reduction of arsenate [As(V)] to arsenite [As(III)], the first step in the...; Region: ArsC_ArsC; cd03034 1310161002991 ArsC family; Region: ArsC; pfam03960 1310161002992 catalytic residues [active] 1310161002993 Uncharacterized membrane protein [Function unknown]; Region: COG3949 1310161002994 Predicted RNA-binding protein, associated with RNAses E/G family [General function prediction only]; Region: COG2306 1310161002995 Predicted membrane GTPase involved in stress response [Signal transduction mechanisms]; Region: TypA; COG1217 1310161002996 Rat sarcoma (Ras)-like superfamily of small guanosine triphosphatases (GTPases); Region: Ras_like_GTPase; cl17170 1310161002997 G1 box; other site 1310161002998 GTP/Mg2+ binding site [chemical binding]; other site 1310161002999 G2 box; other site 1310161003000 Switch I region; other site 1310161003001 G3 box; other site 1310161003002 Switch II region; other site 1310161003003 G4 box; other site 1310161003004 G5 box; other site 1310161003005 BipA_TypA_II: domain II of BipA (also called TypA) having homology to domain II of the elongation factors (EFs) EF-G and EF-Tu. BipA is a highly conserved protein with global regulatory properties in Escherichia coli. BipA is phosphorylated on a...; Region: BipA_TypA_II; cd03691 1310161003006 BipA_TypA_C: a C-terminal portion of BipA or TypA having homology to the C terminal domains of the elongation factors EF-G and EF-2. A member of the ribosome binding GTPase superfamily, BipA is widely distributed in bacteria and plants. BipA is a highly...; Region: BipA_TypA_C; cd03710 1310161003007 The substrate-binding domain of mycobacterial lipoprotein Lpqw contains type 2 periplasmic binding fold; Region: PBP2_Lpqw; cd08501 1310161003008 Bacterial extracellular solute-binding proteins, family 5 Middle; Region: SBP_bac_5; pfam00496 1310161003009 The substrate-binding domain of an ABC-type nickel/oligopeptide-like import system contains the type 2 periplasmic binding fold; Region: PBP2_NikA_DppA_OppA_like; cl01709 1310161003010 GlcNAc-PI de-N-acetylase; Region: PIG-L; cl00929 1310161003011 Ferredoxin [Energy production and conversion]; Region: COG1146 1310161003012 4Fe-4S binding domain; Region: Fer4; pfam00037 1310161003013 N-succinyldiaminopimelate aminotransferase; Reviewed; Region: PRK07865 1310161003014 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 1310161003015 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1310161003016 homodimer interface [polypeptide binding]; other site 1310161003017 catalytic residue [active] 1310161003018 Predicted membrane protein [Function unknown]; Region: COG2246 1310161003019 GtrA-like protein; Region: GtrA; pfam04138 1310161003020 Restriction endonuclease [Defense mechanisms]; Region: McrA; COG1403 1310161003021 HNH nucleases; HNH endonuclease signature which is found in viral, prokaryotic, and eukaryotic proteins. The alignment includes members of the large group of homing endonucleases, yeast intron 1 protein, MutS, as well as bacterial colicins, pyocins, and...; Region: HNHc; cd00085 1310161003022 active site 1310161003023 2,3,4,5-tetrahydropyridine-2,6-dicarboxylate N-succinyltransferase; Region: DapD_actino; TIGR03535 1310161003024 Putative 2,3,4,5-tetrahydropyridine-2,6-dicarboxylate (THDP) N-succinyltransferase (THP succinyltransferase), C-terminal left-handed parallel alpha-helix (LbH) domain: This group is composed of mostly uncharacterized proteins containing an N-terminal...; Region: LbH_THP_succinylT_putative; cd04649 1310161003025 putative trimer interface [polypeptide binding]; other site 1310161003026 putative CoA binding site [chemical binding]; other site 1310161003027 gamma-aminobutyrate permease; Region: GABAperm; TIGR01773 1310161003028 Tryptophan/tyrosine permease family; Region: Trp_Tyr_perm; cl17316 1310161003029 succinyl-diaminopimelate desuccinylase; Reviewed; Region: PRK13007 1310161003030 M20 Peptidase actinobacterial DapE encoded N-succinyl-L,L-diaminopimelic acid desuccinylase; Region: M20_DapE_actinobac; cd05647 1310161003031 metal binding site [ion binding]; metal-binding site 1310161003032 putative dimer interface [polypeptide binding]; other site 1310161003033 Predicted Rossmann fold nucleotide-binding protein [General function prediction only]; Region: COG1611 1310161003034 DHPS subgroup of Pterin binding enzymes. DHPS (dihydropteroate synthase), a functional homodimer, catalyzes the condensation of p-aminobenzoic acid (pABA) in the de novo biosynthesis of folate, which is an essential cofactor in both nucleic acid and...; Region: DHPS; cd00739 1310161003035 dihydropteroate synthase; Region: DHPS; TIGR01496 1310161003036 substrate binding pocket [chemical binding]; other site 1310161003037 dimer interface [polypeptide binding]; other site 1310161003038 inhibitor binding site; inhibition site 1310161003039 putative glucosyl-3-phosphoglycerate synthase; Provisional; Region: PRK13915 1310161003040 Glycosyltransferases involved in cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WcaA; COG0463 1310161003041 Protein of unknown function (DUF3117); Region: DUF3117; pfam11314 1310161003042 Methyltransferase domain; Region: Methyltransf_23; pfam13489 1310161003043 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 1310161003044 S-adenosylmethionine binding site [chemical binding]; other site 1310161003045 Beta-fructosidases (levanase/invertase) [Carbohydrate transport and metabolism]; Region: SacC; COG1621 1310161003046 Glycosyl hydrolase families: GH43, GH62, GH32, GH68; Region: GH43_62_32_68; cl14647 1310161003047 active site 1310161003048 Glycosyl hydrolases family 32 C terminal; Region: Glyco_hydro_32C; pfam08244 1310161003049 glycogen synthase, Corynebacterium family; Region: glgA_Coryne; TIGR02149 1310161003050 This family is most closely related to the GT1 family of glycosyltransferases and named after YqgM in Bacillus licheniformis about which little is known. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to...; Region: GT1_YqgM_like; cd03801 1310161003051 glucose-1-phosphate adenylyltransferase; Provisional; Region: glgC; PRK00844 1310161003052 ADP-glucose pyrophosphorylase is involved in the biosynthesis of glycogen or starch; Region: ADP_Glucose_PP; cd02508 1310161003053 ligand binding site; other site 1310161003054 oligomer interface; other site 1310161003055 Glucose-1-phosphate adenylyltransferase, C-terminal Left-handed parallel beta helix (LbH) domain: Glucose-1-phosphate adenylyltransferase is also known as ADP-glucose synthase or ADP-glucose pyrophosphorylase. It catalyzes the first committed and...; Region: LbH_G1P_AT_C; cd04651 1310161003056 sulfate 1 binding site; other site 1310161003057 Predicted O-methyltransferase [General function prediction only]; Region: COG4122 1310161003058 Methyltransferase domain; Region: Methyltransf_24; pfam13578 1310161003059 RNA polymerase sigma factor SigE; Reviewed; Region: PRK09647 1310161003060 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 1310161003061 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 1310161003062 DNA binding residues [nucleotide binding] 1310161003063 mycothiol system anti-sigma-R factor; Region: antisig_RsrA; cl15806 1310161003064 sec-independent translocase; Provisional; Region: tatB; PRK00182 1310161003065 mttA/Hcf106 family; Region: MttA_Hcf106; cl00788 1310161003066 Domain of unknown function DUF59; Region: DUF59; pfam01883 1310161003067 ATPases involved in chromosome partitioning [Cell division and chromosome partitioning]; Region: Mrp; COG0489 1310161003068 MRP (Multiple Resistance and pH adaptation) is a homologue of the Fer4_NifH superfamily. Like the other members of the superfamily, MRP contains a ATP-binding domain at the N-termini. It is found in bacteria as a membrane-spanning protein and functions...; Region: MRP-like; cd02037 1310161003069 Predicted membrane protein [Function unknown]; Region: COG4420 1310161003070 Mg/Co/Ni transporter MgtE (contains CBS domain) [Inorganic ion transport and metabolism]; Region: MgtE; COG2239 1310161003071 MgtE intracellular N domain; Region: MgtE_N; smart00924 1310161003072 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domain in the magnesium transporter, MgtE. MgtE and its homologs are found in eubacteria, archaebacteria, and eukaryota. Members of this family transport Mg2+ or other...; Region: CBS_pair_Mg_transporter; cd04606 1310161003073 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cl00462 1310161003074 alpha-ketoglutarate decarboxylase; Reviewed; Region: kgd; PRK12270 1310161003075 2-oxoacid dehydrogenases acyltransferase (catalytic domain); Region: 2-oxoacid_dh; pfam00198 1310161003076 Thiamine pyrophosphate (TPP) family, E1 of OGDC-like subfamily, TPP-binding module; composed of proteins similar to the E1 component of the 2-oxoglutarate dehydrogenase multienzyme complex (OGDC). OGDC catalyzes the oxidative decarboxylation of...; Region: TPP_E1_OGDC_like; cd02016 1310161003077 TPP-binding site [chemical binding]; other site 1310161003078 Transketolase, pyrimidine binding domain; Region: Transket_pyr; pfam02779 1310161003079 ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132 1310161003080 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 1310161003081 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 1310161003082 Walker A/P-loop; other site 1310161003083 ATP binding site [chemical binding]; other site 1310161003084 Q-loop/lid; other site 1310161003085 ABC transporter signature motif; other site 1310161003086 Walker B; other site 1310161003087 D-loop; other site 1310161003088 H-loop/switch region; other site 1310161003089 ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132 1310161003090 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 1310161003091 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 1310161003092 Walker A/P-loop; other site 1310161003093 ATP binding site [chemical binding]; other site 1310161003094 Q-loop/lid; other site 1310161003095 ABC transporter signature motif; other site 1310161003096 Walker B; other site 1310161003097 D-loop; other site 1310161003098 H-loop/switch region; other site 1310161003099 shikimate 5-dehydrogenase; Reviewed; Region: PRK12550 1310161003100 Shikimate dehydrogenase substrate binding domain; Region: Shikimate_dh_N; pfam08501 1310161003101 NAD(P) binding domain of Shikimate dehydrogenase; Region: NAD_bind_Shikimate_DH; cd01065 1310161003102 shikimate binding site; other site 1310161003103 NAD(P) binding site [chemical binding]; other site 1310161003104 Carboxylesterase type B [Lipid metabolism]; Region: PnbA; COG2272 1310161003105 Esterases and lipases (includes fungal lipases, cholinesterases, etc.) These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cd00312 1310161003106 substrate binding pocket [chemical binding]; other site 1310161003107 catalytic triad [active] 1310161003108 FhuF 2Fe-2S C-terminal domain; Region: FhuF_C; pfam11575 1310161003109 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1310161003110 putative substrate translocation pore; other site 1310161003111 Major Facilitator Superfamily; Region: MFS_1; pfam07690 1310161003112 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1310161003113 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1310161003114 Major Facilitator Superfamily; Region: MFS_1; pfam07690 1310161003115 putative substrate translocation pore; other site 1310161003116 5-methyltetrahydropteroyltriglutamate--homocysteine S-methyltransferase; Provisional; Region: PRK05222 1310161003117 CIMS - Cobalamine-independent methonine synthase, or MetE, N-terminal domain_like. Many members have been characterized as 5-methyltetrahydropteroyltriglutamate-homocysteine methyltransferases, EC:2.1.1.14, mostly from bacteria and plants. This enzyme...; Region: CIMS_N_terminal_like; cd03312 1310161003118 THF binding site; other site 1310161003119 CIMS - Cobalamine-independent methonine synthase, or MetE, C-terminal domain_like. Many members have been characterized as 5-methyltetrahydropteroyltriglutamate-homocysteine methyltransferases, EC:2.1.1.14, mostly from bacteria and plants. This enzyme...; Region: CIMS_C_terminal_like; cd03311 1310161003120 substrate binding site [chemical binding]; other site 1310161003121 THF binding site; other site 1310161003122 zinc-binding site [ion binding]; other site 1310161003123 Predicted flavoprotein involved in K+ transport [Inorganic ion transport and metabolism]; Region: TrkA; COG2072 1310161003124 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500 1310161003125 Predicted esterase of the alpha-beta hydrolase superfamily [General function prediction only]; Region: COG4667 1310161003126 Hypothetical patatin similar to yjju protein of Escherichia coli; Region: Pat_hypo_Ecoli_yjju_like; cd07208 1310161003127 active site 1310161003128 nucleophile elbow; other site 1310161003129 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 1310161003130 Condensation domain; Region: Condensation; pfam00668 1310161003131 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl17182 1310161003132 thiol reductant ABC exporter, CydC subunit; Region: CydC; TIGR02868 1310161003133 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 1310161003134 Q-loop/lid; other site 1310161003135 ABC transporter signature motif; other site 1310161003136 Walker B; other site 1310161003137 D-loop; other site 1310161003138 H-loop/switch region; other site 1310161003139 ABC-type transport system involved in cytochrome bd biosynthesis, ATPase and permease components [Energy production and conversion / Posttranslational modification, protein turnover, chaperones]; Region: CydD; COG4988 1310161003140 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 1310161003141 ATP-binding cassette domain of multidrug resistance protein-like transporters; Region: ABCC_MRP_Like; cd03228 1310161003142 Walker A/P-loop; other site 1310161003143 ATP binding site [chemical binding]; other site 1310161003144 Q-loop/lid; other site 1310161003145 ABC transporter signature motif; other site 1310161003146 Walker B; other site 1310161003147 D-loop; other site 1310161003148 H-loop/switch region; other site 1310161003149 Cytochrome oxidase subunit II; Region: Cyto_ox_2; pfam02322 1310161003150 cytochrome d ubiquinol oxidase subunit 2; Provisional; Region: PRK15003; cl12219 1310161003151 Bacterial Cytochrome Ubiquinol Oxidase; Region: Bac_Ubq_Cox; pfam01654 1310161003152 N-terminal putative catalytic domain of uncharacterized prokaryotic and archeal HKD family nucleases fused to a DEAD/DEAH box helicase domain; Region: PLDc_N_DEXD_b2; cd09204 1310161003153 PLD-like domain; Region: PLDc_2; pfam13091 1310161003154 putative homodimer interface [polypeptide binding]; other site 1310161003155 putative active site [active] 1310161003156 catalytic site [active] 1310161003157 DNA or RNA helicases of superfamily II [Transcription / DNA replication, recombination, and repair]; Region: SSL2; COG1061 1310161003158 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 1310161003159 ATP binding site [chemical binding]; other site 1310161003160 putative Mg++ binding site [ion binding]; other site 1310161003161 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 1310161003162 nucleotide binding region [chemical binding]; other site 1310161003163 ATP-binding site [chemical binding]; other site 1310161003164 Domain of unknown function (DUF3427); Region: DUF3427; pfam11907 1310161003165 The MutT pyrophosphohydrolase is a prototypical Nudix hydrolase that catalyzes the hydrolysis of nucleoside and deoxynucleoside triphosphates (NTPs and dNTPs) by substitution at a beta-phosphorus to yield a nucleotide monophosphate (NMP) and inorganic...; Region: MutT_pyrophosphohydrolase; cd03425 1310161003166 active site 1310161003167 8-oxo-dGMP binding site [chemical binding]; other site 1310161003168 nudix motif; other site 1310161003169 metal binding site [ion binding]; metal-binding site 1310161003170 Gamma-aminobutyrate permease and related permeases [Amino acid transport and metabolism]; Region: AnsP; COG1113 1310161003171 Superfamily II DNA and RNA helicases [DNA replication, recombination, and repair / Transcription / Translation, ribosomal structure and biogenesis]; Region: SrmB; COG0513 1310161003172 DEAD-box helicases. A diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker B motif; Region: DEADc; cd00268 1310161003173 ATP binding site [chemical binding]; other site 1310161003174 Mg++ binding site [ion binding]; other site 1310161003175 motif III; other site 1310161003176 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 1310161003177 nucleotide binding region [chemical binding]; other site 1310161003178 ATP-binding site [chemical binding]; other site 1310161003179 RNA recognition motif in Escherichia coli cold-shock DEAD box protein A (CsdA) and similar proteins; Region: RRM_EcCsdA_like; cd12499 1310161003180 putative RNA binding site [nucleotide binding]; other site 1310161003181 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 1310161003182 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 1310161003183 3-(3-hydroxyphenyl)propionate hydroxylase; Validated; Region: mhpA; PRK06183 1310161003184 ubiquinone biosynthesis hydroxylase family protein; Provisional; Region: PRK07608; cl17314 1310161003185 Alcohol dehydrogenase, class IV [Energy production and conversion]; Region: EutG; COG1454 1310161003186 Maleylacetate reductase is involved in many aromatic compounds degradation pathways of aerobic microbes; Region: MAR; cd08177 1310161003187 active site 1310161003188 dimer interface [polypeptide binding]; other site 1310161003189 metal binding site [ion binding]; metal-binding site 1310161003190 Intradiol dioxygenases catalyze the critical ring-cleavage step in the conversion of catecholate derivatives to citric acid cycle intermediates. This family contains catechol 1,2-dioxygenases and protocatechuate 3,4-dioxygenases which are mononuclear...; Region: intradiol_dioxygenase; cl17208 1310161003191 Protocatechuate 3,4-dioxygenase beta subunit [Secondary metabolites biosynthesis, transport, and catabolism]; Region: PcaH; COG3485 1310161003192 active site 1310161003193 Protein of unknown function (DUF1524); Region: DUF1524; pfam07510 1310161003194 Predicted symporter [General function prediction only]; Region: DhlC; COG4147 1310161003195 Na(+)/proline cotransporter PutP and related proteins; solute binding domain; Region: SLC5sbd_PutP; cd11475 1310161003196 Na binding site [ion binding]; other site 1310161003197 SNF2 Helicase protein; Region: DUF3670; pfam12419 1310161003198 SNF2 family N-terminal domain; Region: SNF2_N; pfam00176 1310161003199 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 1310161003200 putative Mg++ binding site [ion binding]; other site 1310161003201 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 1310161003202 nucleotide binding region [chemical binding]; other site 1310161003203 ATP-binding site [chemical binding]; other site 1310161003204 Uncharacterized conserved protein [Function unknown]; Region: COG4279 1310161003205 DNA repair exonuclease [DNA replication, recombination, and repair]; Region: SbcD; COG0420 1310161003206 Mre11 nuclease, N-terminal metallophosphatase domain; Region: MPP_Mre11_N; cd00840 1310161003207 active site 1310161003208 metal binding site [ion binding]; metal-binding site 1310161003209 DNA binding site [nucleotide binding] 1310161003210 ATPase involved in DNA repair [DNA replication, recombination, and repair]; Region: SbcC; COG0419 1310161003211 Uncharacterized conserved protein [Function unknown]; Region: COG4717 1310161003212 Esterase/lipase [Lipid metabolism]; Region: Aes; COG0657 1310161003213 Short chain fatty acids transporter [Lipid metabolism]; Region: AtoE; COG2031 1310161003214 Short chain fatty acids transporter [Lipid metabolism]; Region: AtoE; COG2031 1310161003215 Uncharacterized conserved protein [Function unknown]; Region: COG2353 1310161003216 Transcriptional regulators [Transcription]; Region: MarR; COG1846 1310161003217 MarR family; Region: MarR_2; pfam12802 1310161003218 Putative stress-responsive transcriptional regulator [Transcription / Signal transduction mechanisms]; Region: PspC; COG1983 1310161003219 cAMP-binding proteins - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases [Signal transduction mechanisms]; Region: Crp; COG0664 1310161003220 effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038 1310161003221 ligand binding site [chemical binding]; other site 1310161003222 flexible hinge region; other site 1310161003223 helix_turn_helix, cAMP Regulatory protein C-terminus; DNA binding domain of prokaryotic regulatory proteins belonging to the catabolite activator protein family; Region: HTH_CRP; cd00092 1310161003224 non-specific DNA interactions [nucleotide binding]; other site 1310161003225 DNA binding site [nucleotide binding] 1310161003226 sequence specific DNA binding site [nucleotide binding]; other site 1310161003227 putative cAMP binding site [chemical binding]; other site 1310161003228 Heavy-metal-associated domain (HMA) is a conserved domain of approximately 30 amino acid residues found in a number of proteins that transport or detoxify heavy metals, for example, the CPx-type heavy metal ATPases and copper chaperones. HMA domain...; Region: HMA; cd00371 1310161003229 metal-binding site [ion binding] 1310161003230 heavy metal translocating P-type ATPase; Region: ATPase-IB_hvy; TIGR01525 1310161003231 E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122 1310161003232 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 1310161003233 motif II; other site 1310161003234 Guanosine polyphosphate pyrophosphohydrolases/synthetases [Signal transduction mechanisms / Transcription]; Region: SpoT; COG0317 1310161003235 Nucleotidyltransferase (NT) domain of RelA- and SpoT-like ppGpp synthetases and hydrolases; Region: NT_Rel-Spo_like; cd05399 1310161003236 synthetase active site [active] 1310161003237 NTP binding site [chemical binding]; other site 1310161003238 metal binding site [ion binding]; metal-binding site 1310161003239 TAP-like protein; Region: Abhydrolase_4; pfam08386 1310161003240 arginyl-tRNA synthetase; Reviewed; Region: argS; PRK01611 1310161003241 Arginyl tRNA synthetase N terminal dom; Region: Arg_tRNA_synt_N; smart01016 1310161003242 catalytic core domain of arginyl-tRNA synthetases; Region: ArgRS_core; cd00671 1310161003243 active site 1310161003244 HIGH motif; other site 1310161003245 KMSK motif region; other site 1310161003246 Anticodon-binding domain of class Ia aminoacyl tRNA synthetases and similar domains; Region: Anticodon_Ia_like; cl12020 1310161003247 tRNA binding surface [nucleotide binding]; other site 1310161003248 anticodon binding site; other site 1310161003249 diaminopimelate decarboxylase; Region: lysA; TIGR01048 1310161003250 Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzyme Diaminopimelate Decarboxylase; Region: PLPDE_III_DapDC; cd06828 1310161003251 active site 1310161003252 pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site 1310161003253 substrate binding site [chemical binding]; other site 1310161003254 catalytic residues [active] 1310161003255 dimer interface [polypeptide binding]; other site 1310161003256 homoserine dehydrogenase; Provisional; Region: PRK06349 1310161003257 Homoserine dehydrogenase, NAD binding domain; Region: NAD_binding_3; pfam03447 1310161003258 Homoserine dehydrogenase; Region: Homoserine_dh; pfam00742 1310161003259 ACT_HSDH_Hom CD includes the C-terminal ACT domain of the NAD(P)H-dependent, homoserine dehydrogenase (HSDH) and related domains; Region: ACT_HSDH-Hom; cd04881 1310161003260 homoserine kinase; Provisional; Region: PRK01212 1310161003261 Predicted transcriptional regulator [Transcription]; Region: COG2345 1310161003262 Nitrate reductase gamma subunit; Region: Nitrate_red_gam; pfam02665 1310161003263 Nitrate reductase delta subunit [Energy production and conversion]; Region: NarJ; COG2180 1310161003264 Nitrate reductase beta subunit [Energy production and conversion]; Region: NarY; COG1140 1310161003265 Nitrate reductase alpha subunit [Energy production and conversion]; Region: NarG; COG5013 1310161003266 Respiratory nitrate reductase A (NarGHI), alpha chain (NarG) and related proteins. Under anaerobic conditions in the presence of nitrate, E. coli synthesizes the cytoplasmic membrane-bound quinol-nitrate oxidoreductase (NarGHI), which reduces nitrate to...; Region: MopB_Nitrate-R-NarG-like; cd02750 1310161003267 [4Fe-4S] binding site [ion binding]; other site 1310161003268 Molybdopterin-Binding (MopB) domain of the MopB superfamily of proteins, a large, diverse, heterogeneous superfamily of enzymes that, in general, bind molybdopterin as a cofactor. The MopB domain is found in a wide variety of molybdenum- and...; Region: Molybdopterin-Binding; cl09928 1310161003269 Molybdopterin-Binding (MopB) domain of the MopB superfamily of proteins, a large, diverse, heterogeneous superfamily of enzymes that, in general, bind molybdopterin as a cofactor. The MopB domain is found in a wide variety of molybdenum- and...; Region: Molybdopterin-Binding; cl09928 1310161003270 Molybdopterin-Binding (MopB) domain of the MopB superfamily of proteins, a large, diverse, heterogeneous superfamily of enzymes that, in general, bind molybdopterin as a cofactor. The MopB domain is found in a wide variety of molybdenum- and...; Region: Molybdopterin-Binding; cl09928 1310161003271 Respiratory nitrate reductase A (NarGHI), alpha chain (NarG) and related proteins. Under anaerobic conditions in the presence of nitrate, E. coli synthesizes the cytoplasmic membrane-bound quinol-nitrate oxidoreductase (NarGHI), which reduces nitrate to...; Region: MopB_CT_Nitrate-R-NarG-like; cd02776 1310161003272 molybdopterin cofactor binding site; other site 1310161003273 Nitrate/nitrite transporter [Inorganic ion transport and metabolism]; Region: NarK; COG2223 1310161003274 MogA_MoaB family. Members of this family are involved in biosynthesis of the molybdenum cofactor (MoCF) an essential cofactor of a diverse group of redox enzymes. MoCF biosynthesis is an evolutionarily conserved pathway present in eubacteria, archaea; Region: MogA_MoaB; cd00886 1310161003275 MPT binding site; other site 1310161003276 trimer interface [polypeptide binding]; other site 1310161003277 PAP2, bacterial acid phosphatase or class A non-specific acid phosphatases. These enzymes catalyze phosphomonoester hydrolysis, with optimal activity in low pH conditions. They are secreted into the periplasmic space, and their physiological role remains...; Region: PAP2_acid_phosphatase; cd03397 1310161003278 Membrane-associated phospholipid phosphatase [Lipid metabolism]; Region: PgpB; COG0671 1310161003279 active site 1310161003280 Autotransporter-associated beta strand repeat; Region: Autotrns_rpt; pfam12951 1310161003281 Hemolysins and related proteins containing CBS domains [General function prediction only]; Region: TlyC; COG1253 1310161003282 Domain of unknown function DUF21; Region: DUF21; pfam01595 1310161003283 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains associated with the CorC_HlyC domain. CorC_HlyC is a transporter associated domain. This small domain is found in Na+/H+ antiporters, in proteins involved in...; Region: CBS_pair_CorC_HlyC_assoc; cd04590 1310161003284 Hemolysins and related proteins containing CBS domains [General function prediction only]; Region: TlyC; COG1253 1310161003285 Domain of unknown function DUF21; Region: DUF21; pfam01595 1310161003286 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains associated with the CorC_HlyC domain. CorC_HlyC is a transporter associated domain. This small domain is found in Na+/H+ antiporters, in proteins involved in...; Region: CBS_pair_CorC_HlyC_assoc; cd04590 1310161003287 Transporter associated domain; Region: CorC_HlyC; pfam03471 1310161003288 MobA catalyzes the formation of molybdopterin guanine dinucleotide; Region: MobA; cd02503 1310161003289 GTP binding site; other site 1310161003290 Molybdopterin biosynthesis enzyme [Coenzyme metabolism]; Region: MoeA; COG0303 1310161003291 MoeA family. Members of this family are involved in biosynthesis of the molybdenum cofactor (MoCF), an essential cofactor of a diverse group of redox enzymes. MoCF biosynthesis is an evolutionarily conserved pathway present in eubacteria, archaea and...; Region: MoeA; cd00887 1310161003292 dimer interface [polypeptide binding]; other site 1310161003293 putative functional site; other site 1310161003294 putative MPT binding site; other site 1310161003295 molybdenum cofactor biosynthesis protein A; Reviewed; Region: moaA; PRK00164 1310161003296 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 1310161003297 FeS/SAM binding site; other site 1310161003298 Molybdenum Cofactor Synthesis C; Region: Mob_synth_C; pfam06463 1310161003299 long-chain-fatty-acid--CoA ligase; Validated; Region: PRK05620 1310161003300 Fatty acyl-CoA synthetases similar to LC-FACS from Thermus thermophiles; Region: ttLC_FACS_AlkK_like; cd12119 1310161003301 dimer interface [polypeptide binding]; other site 1310161003302 acyl-activating enzyme (AAE) consensus motif; other site 1310161003303 putative active site [active] 1310161003304 AMP binding site [chemical binding]; other site 1310161003305 putative CoA binding site [chemical binding]; other site 1310161003306 Rho termination factor, N-terminal domain; Region: Rho_N; smart00959 1310161003307 transcription termination factor Rho; Provisional; Region: PRK12608 1310161003308 S1_like: Ribosomal protein S1-like RNA-binding domain. Found in a wide variety of RNA-associated proteins. Originally identified in S1 ribosomal protein. This superfamily also contains the Cold Shock Domain (CSD), which is a homolog of the S1 domain; Region: S1_like; cl09927 1310161003309 RNA binding site [nucleotide binding]; other site 1310161003310 Transcription termination factor rho is a bacterial ATP-dependent RNA/DNA helicase. It is a homohexamer. Each monomer consists of an N-terminal domain of the OB fold, which is responsible for binding to cysteine rich nucleotides. This alignment is of the...; Region: rho_factor; cd01128 1310161003311 multimer interface [polypeptide binding]; other site 1310161003312 Walker A motif; other site 1310161003313 ATP binding site [chemical binding]; other site 1310161003314 Walker B motif; other site 1310161003315 peptide chain release factor 1; Validated; Region: prfA; PRK00591 1310161003316 This domain is found in peptide chain release factors; Region: PCRF; smart00937 1310161003317 RF-1 domain; Region: RF-1; pfam00472 1310161003318 N5-glutamine S-adenosyl-L-methionine-dependent methyltransferase; Provisional; Region: PRK09328 1310161003319 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 1310161003320 S-adenosylmethionine binding site [chemical binding]; other site 1310161003321 RNA recognition motif (RRM) superfamily; Region: RRM_SF; cl17169 1310161003322 Putative translation factor (SUA5) [Translation, ribosomal structure and biogenesis]; Region: SUA5; COG0009 1310161003323 UDP-N-acetylmuramyl pentapeptide phosphotransferase/UDP-N- acetylglucosamine-1-phosphate transferase [Cell envelope biogenesis, outer membrane]; Region: Rfe; COG0472 1310161003324 This subfamily contains Escherichia coli WecA, Bacillus subtilis TagO and related proteins. WecA is an UDP-N-acetylglucosamine (GlcNAc):undecaprenyl-phosphate (Und-P) GlcNAc-1-phosphate transferase that catalyzes the formation of a phosphodiester bond...; Region: GT_WecA_like; cd06853 1310161003325 Mg++ binding site [ion binding]; other site 1310161003326 putative catalytic motif [active] 1310161003327 substrate binding site [chemical binding]; other site 1310161003328 F0F1 ATP synthase subunit C; Validated; Region: PRK07874 1310161003329 F0F1 ATP synthase subunit B; Validated; Region: PRK05759 1310161003330 F0F1-type ATP synthase, subunit b [Energy production and conversion]; Region: AtpF; COG0711 1310161003331 F0F1 ATP synthase subunit delta; Provisional; Region: PRK13430 1310161003332 ATP synthase delta (OSCP) subunit; Region: OSCP; pfam00213 1310161003333 F0F1 ATP synthase subunit alpha; Validated; Region: PRK09281 1310161003334 ATP synthase alpha/beta family, beta-barrel domain; Region: ATP-synt_ab_N; pfam02874 1310161003335 F1 ATP synthase alpha, central domain. The F-ATPase is found in bacterial plasma membranes, mitochondrial inner membranes and in chloroplast thylakoid membranes. It has also been found in the archaea Methanosarcina barkeri. It uses a proton gradient to...; Region: F1_ATPase_alpha; cd01132 1310161003336 beta subunit interaction interface [polypeptide binding]; other site 1310161003337 Walker A motif; other site 1310161003338 ATP binding site [chemical binding]; other site 1310161003339 Walker B motif; other site 1310161003340 ATP synthase alpha/beta chain, C terminal domain; Region: ATP-synt_ab_C; pfam00306 1310161003341 mitochondrial ATP synthase gamma subunit; Region: F1-ATPase_gamma; cd12151 1310161003342 core domain interface [polypeptide binding]; other site 1310161003343 delta subunit interface [polypeptide binding]; other site 1310161003344 epsilon subunit interface [polypeptide binding]; other site 1310161003345 F0F1 ATP synthase subunit beta; Validated; Region: PRK09280 1310161003346 ATP synthase alpha/beta family, beta-barrel domain; Region: ATP-synt_ab_N; pfam02874 1310161003347 F1 ATP synthase beta subunit, nucleotide-binding domain. The F-ATPase is found in bacterial plasma membranes, mitochondrial inner membranes and in chloroplast thylakoid membranes. It has also been found in the archaea Methanosarcina barkeri. It uses a...; Region: F1-ATPase_beta; cd01133 1310161003348 alpha subunit interaction interface [polypeptide binding]; other site 1310161003349 Walker A motif; other site 1310161003350 ATP binding site [chemical binding]; other site 1310161003351 Walker B motif; other site 1310161003352 inhibitor binding site; inhibition site 1310161003353 ATP synthase alpha/beta chain, C terminal domain; Region: ATP-synt_ab_C; pfam00306 1310161003354 F0F1 ATP synthase subunit epsilon; Validated; Region: atpC; PRK00571 1310161003355 mitochondrial ATP synthase delta subunit; Region: F1-ATPase_delta; cd12152 1310161003356 gamma subunit interface [polypeptide binding]; other site 1310161003357 epsilon subunit interface [polypeptide binding]; other site 1310161003358 LBP interface [polypeptide binding]; other site 1310161003359 Protein of unknown function (DUF2550); Region: DUF2550; pfam10739 1310161003360 Predicted nuclease of the RecB family [DNA replication, recombination, and repair]; Region: COG1637 1310161003361 hypothetical protein; Provisional; Region: PRK03298 1310161003362 Methylmalonyl-CoA epimerase (MMCE); Region: MMCE; cd07249 1310161003363 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 1310161003364 dimer interface [polypeptide binding]; other site 1310161003365 substrate binding site [chemical binding]; other site 1310161003366 metal binding site [ion binding]; metal-binding site 1310161003367 Uncharacterized conserved protein [Function unknown]; Region: COG0011 1310161003368 Thioredoxin domain-containing protein [Posttranslational modification, protein turnover, chaperones]; Region: COG3118 1310161003369 ybbN protein family; ybbN is a hypothetical protein containing a redox-inactive TRX-like domain. Its gene has been sequenced from several gammaproteobacteria and actinobacteria; Region: ybbN; cd02956 1310161003370 Alkanesulfonate monoxygenase is the monoxygenase of a two-component system that catalyzes the conversion of alkanesulfonates to the corresponding aldehyde and sulfite. Alkanesulfonate monoxygenase (SsuD) has an absolute requirement for reduced flavin...; Region: Alkanesulfonate_monoxygenase; cd01094 1310161003371 alkanesulfonate monooxygenase; Provisional; Region: PRK00719 1310161003372 dimer interface [polypeptide binding]; other site 1310161003373 active site 1310161003374 non-prolyl cis peptide bond; other site 1310161003375 insertion regions; other site 1310161003376 ABC-type nitrate/sulfonate/bicarbonate transport system, permease component [Inorganic ion transport and metabolism]; Region: TauC; COG0600 1310161003377 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1310161003378 dimer interface [polypeptide binding]; other site 1310161003379 conserved gate region; other site 1310161003380 putative PBP binding loops; other site 1310161003381 ABC-ATPase subunit interface; other site 1310161003382 ABC-type nitrate/sulfonate/bicarbonate transport system, ATPase component [Inorganic ion transport and metabolism]; Region: TauB; COG1116 1310161003383 ATP-binding cassette domain of the nitrate and sulfonate transporters; Region: ABC_NrtD_SsuB_transporters; cd03293 1310161003384 Walker A/P-loop; other site 1310161003385 ATP binding site [chemical binding]; other site 1310161003386 Q-loop/lid; other site 1310161003387 ABC transporter signature motif; other site 1310161003388 Walker B; other site 1310161003389 D-loop; other site 1310161003390 H-loop/switch region; other site 1310161003391 ABC transporter, substrate-binding protein, aliphatic sulfonates family; Region: SsuA_fam; TIGR01728 1310161003392 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 1310161003393 substrate binding pocket [chemical binding]; other site 1310161003394 membrane-bound complex binding site; other site 1310161003395 hinge residues; other site 1310161003396 Domain of unknown function (DUF4303); Region: DUF4303; pfam14136 1310161003397 glycogen branching enzyme; Provisional; Region: PRK05402 1310161003398 N-terminal Early set domain associated with the catalytic domain of prokaryotic glycogen branching enzyme; Region: E_set_GBE_prok_N; cd02855 1310161003399 Alpha amylase catalytic domain found in the Glycogen branching enzyme (also called 1,4-alpha-glucan branching enzyme); Region: AmyAc_Glg_BE; cd11322 1310161003400 active site 1310161003401 catalytic site [active] 1310161003402 Alpha amylase, C-terminal all-beta domain; Region: Alpha-amylase_C; pfam02806 1310161003403 Domain of unknown function (DUF3416); Region: DUF3416; pfam11896 1310161003404 Alpha amylase catalytic domain family; Region: AmyAc_family; cl07893 1310161003405 Glycosidases [Carbohydrate transport and metabolism]; Region: AmyA; COG0366 1310161003406 active site 1310161003407 catalytic site [active] 1310161003408 The electron transfer flavoprotein (ETF) serves as a specific electron acceptor for various mitochondrial dehydrogenases. ETF transfers electrons to the main respiratory chain via ETF-ubiquinone oxidoreductase. ETF is an heterodimer that consists of an...; Region: ETF_beta; cd01714 1310161003409 Ligand binding site [chemical binding]; other site 1310161003410 Electron transfer flavoprotein domain; Region: ETF; pfam01012 1310161003411 Electron transfer flavoprotein, alpha subunit [Energy production and conversion]; Region: FixB; COG2025 1310161003412 The electron transfer flavoprotein (ETF) serves as a specific electron acceptor for various mitochondrial dehydrogenases. ETF transfers electrons to the main respiratory chain via ETF-ubiquinone oxidoreductase. ETF is an heterodimer that consists of an...; Region: ETF_alpha; cd01715 1310161003413 Electron transfer flavoprotein FAD-binding domain; Region: ETF_alpha; pfam00766 1310161003414 cysteine desulfurase NifS; Region: FeS_nifS; TIGR03402 1310161003415 Cysteine sulfinate desulfinase/cysteine desulfurase and related enzymes [Amino acid transport and metabolism]; Region: NifS; COG1104 1310161003416 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 1310161003417 catalytic residue [active] 1310161003418 Toxin module HipA, protein kinase of phosphatidylinositol 3/4-kinase superfamily [General function prediction only]; Region: HipA; COG3550 1310161003419 HipA N-terminal domain; Region: couple_hipA; TIGR03071 1310161003420 HipA-like N-terminal domain; Region: HipA_N; pfam07805 1310161003421 HipA-like C-terminal domain; Region: HipA_C; pfam07804 1310161003422 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 1310161003423 salt bridge; other site 1310161003424 non-specific DNA binding site [nucleotide binding]; other site 1310161003425 sequence-specific DNA binding site [nucleotide binding]; other site 1310161003426 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 1310161003427 Coenzyme A binding pocket [chemical binding]; other site 1310161003428 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 1310161003429 S-adenosylmethionine binding site [chemical binding]; other site 1310161003430 AAA ATPase domain; Region: AAA_16; pfam13191 1310161003431 Type II secretory pathway, component ExeA (predicted ATPase) [Intracellular trafficking and secretion]; Region: ExeA; COG3267 1310161003432 Iron dependent repressor, N-terminal DNA binding domain; Region: Fe_dep_repress; pfam01325 1310161003433 Predicted tRNA(5-methylaminomethyl-2-thiouridylate) methyltransferase, contains the PP-loop ATPase domain [Translation, ribosomal structure and biogenesis]; Region: TrmU; COG0482 1310161003434 tRNA methyl transferase. This family represents tRNA(5-methylaminomethyl-2-thiouridine)-methyltransferase which is involved in the biosynthesis of the modified nucleoside 5-methylaminomethyl-2-thiouridine present in the wobble position of some tRNAs; Region: tRNA_Me_trans; cd01998 1310161003435 The URO-D_CIMS_like protein superfamily includes bacterial and eukaryotic uroporphyrinogen decarboxylases (URO-D), coenzyme M methyltransferases and other putative bacterial methyltransferases, as well as cobalamine (B12) independent methionine synthases; Region: URO-D_CIMS_like; cl00464 1310161003436 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1310161003437 Major Facilitator Superfamily; Region: MFS_1; pfam07690 1310161003438 putative substrate translocation pore; other site 1310161003439 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1310161003440 DNA polymerase III, epsilon subunit and related 3'-5' exonucleases [DNA replication, recombination, and repair]; Region: DnaQ; COG0847 1310161003441 DEDDh 3'-5' exonuclease domain family; Region: DEDDh; cd06127 1310161003442 active site 1310161003443 catalytic site [active] 1310161003444 substrate binding site [chemical binding]; other site 1310161003445 NAD-dependent DNA ligase LigA; Validated; Region: ligA; PRK07956 1310161003446 NAD+ dependent DNA ligase adenylation domain. DNA ligases catalyze the crucial step of joining the breaks in duplex DNA during DNA replication, repair and recombination, utilizing either ATP or NAD(+) as a cofactor, but using the same basic reaction...; Region: LIGANc; cd00114 1310161003447 nucleotide binding pocket [chemical binding]; other site 1310161003448 K-X-D-G motif; other site 1310161003449 catalytic site [active] 1310161003450 NAD-dependent DNA ligase OB-fold domain; Region: DNA_ligase_OB; pfam03120 1310161003451 NAD-dependent DNA ligase C4 zinc finger domain; Region: DNA_ligase_ZBD; pfam03119 1310161003452 Breast Cancer Suppressor Protein (BRCA1), carboxy-terminal domain. The BRCT domain is found within many DNA damage repair and cell cycle checkpoint proteins. The unique diversity of this domain superfamily allows BRCT modules to interact forming homo...; Region: BRCT; cd00027 1310161003453 Dimer interface [polypeptide binding]; other site 1310161003454 ACT domains are commonly involved in specifically binding an amino acid or other small ligand leading to regulation of the enzyme; Region: ACT; cl09141 1310161003455 aspartyl/glutamyl-tRNA amidotransferase subunit C; Reviewed; Region: gatC; PRK00034 1310161003456 Asp-tRNAAsn/Glu-tRNAGln amidotransferase A subunit and related amidases [Translation, ribosomal structure and biogenesis]; Region: GatA; COG0154 1310161003457 aspartyl/glutamyl-tRNA amidotransferase subunit A; Reviewed; Region: gatA; PRK00012 1310161003458 Siderophore-interacting protein [Inorganic ion transport and metabolism]; Region: ViuB; COG2375 1310161003459 Siderophore interacting proteins share the domain structure of the ferredoxin reductase like family. Siderophores are produced in various bacteria (and some plants) to extract iron from hosts. Binding constants are high, so iron can be pilfered from...; Region: siderophore_interacting; cd06193 1310161003460 FAD binding pocket [chemical binding]; other site 1310161003461 FAD binding motif [chemical binding]; other site 1310161003462 phosphate binding motif [ion binding]; other site 1310161003463 NAD binding pocket [chemical binding]; other site 1310161003464 6-phosphofructokinase; Region: PFKA_ATP; TIGR02482 1310161003465 phosphofructokinase; Region: PFK_mixed; TIGR02483 1310161003466 active site 1310161003467 ADP/pyrophosphate binding site [chemical binding]; other site 1310161003468 dimerization interface [polypeptide binding]; other site 1310161003469 allosteric effector site; other site 1310161003470 fructose-1,6-bisphosphate binding site; other site 1310161003471 Transcriptional regulators [Transcription]; Region: PurR; COG1609 1310161003472 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 1310161003473 DNA binding site [nucleotide binding] 1310161003474 domain linker motif; other site 1310161003475 Ligand-binding domain of DNA-binding regulatory protein from Corynebacterium glutamicum which has a unique ability to produce significant amounts of L-glutamate directly from cheap sugar and ammonia; Region: PBP1_LacI_like_13; cd06299 1310161003476 dimerization interface [polypeptide binding]; other site 1310161003477 putative ligand binding site [chemical binding]; other site 1310161003478 ABC-type sugar transport system, ATPase component [Carbohydrate transport and metabolism]; Region: MglA; COG1129 1310161003479 First domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_I; cd03216 1310161003480 Walker A/P-loop; other site 1310161003481 ATP binding site [chemical binding]; other site 1310161003482 Q-loop/lid; other site 1310161003483 ABC transporter signature motif; other site 1310161003484 Walker B; other site 1310161003485 D-loop; other site 1310161003486 H-loop/switch region; other site 1310161003487 Second domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_II; cd03215 1310161003488 Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653 1310161003489 Transmembrane subunit (TM) of Escherichia coli AraH and related proteins. E. coli AraH is the TM of a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of the monosaccharide arabinose. This group...; Region: TM_PBP1_transp_AraH_like; cd06579 1310161003490 TM-ABC transporter signature motif; other site 1310161003491 Periplasmic sugar-binding domain of the thermophilic Thermoanaerobacter tengcongensis ribose binding protein (ttRBP) and its mesophilic homologs; Region: PBP1_ribose_binding; cd06323 1310161003492 Periplasmic binding protein domain; Region: Peripla_BP_4; pfam13407 1310161003493 ligand binding site [chemical binding]; other site 1310161003494 dimerization interface [polypeptide binding]; other site 1310161003495 D-ribose pyranase; Provisional; Region: PRK11797 1310161003496 Acetyltransferase (GNAT) domain; Region: Acetyltransf_3; pfam13302 1310161003497 Acetyltransferase (GNAT) family; Region: Acetyltransf_1; pfam00583 1310161003498 Fe3+-siderophore binding domain FhuD. These proteins have been shown to function as initial receptors in ABC transport of Fe3+-siderophores in many eubacterial species. They belong to the TroA-like superfamily of helical backbone metal receptor proteins...; Region: FhuD; cd01146 1310161003499 Periplasmic binding protein; Region: Peripla_BP_2; pfam01497 1310161003500 siderophore binding site; other site 1310161003501 Predicted Na+-dependent transporter [General function prediction only]; Region: COG0385 1310161003502 Sodium Bile acid symporter family; Region: SBF; pfam01758 1310161003503 aspartyl/glutamyl-tRNA amidotransferase subunit B; Validated; Region: gatB; PRK05477 1310161003504 GatB/GatE catalytic domain; Region: GatB_N; pfam02934 1310161003505 GatB domain; Region: GatB_Yqey; pfam02637 1310161003506 Predicted dinucleotide-binding enzymes [General function prediction only]; Region: COG2085 1310161003507 NADP oxidoreductase coenzyme F420-dependent; Region: F420_oxidored; cl17232 1310161003508 L-lysine exporter; Region: 2a75; TIGR00948 1310161003509 chromosome replication initiation inhibitor protein; Validated; Region: PRK03635 1310161003510 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 1310161003511 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 1310161003512 dimerization interface [polypeptide binding]; other site 1310161003513 Predicted glutathione S-transferase [Posttranslational modification, protein turnover, chaperones]; Region: ECM4; COG0435 1310161003514 Glutathione S-transferase, N-terminal domain; Region: GST_N_2; pfam13409 1310161003515 C-terminal, alpha helical domain of Class Omega-like Glutathione S-transferases; Region: GST_C_Omega_like; cd03190 1310161003516 putative dimer interface [polypeptide binding]; other site 1310161003517 N-terminal domain interface [polypeptide binding]; other site 1310161003518 putative substrate binding pocket (H-site) [chemical binding]; other site 1310161003519 Predicted membrane protein [Function unknown]; Region: COG2259 1310161003520 dihydroxy-acid dehydratase; Provisional; Region: PRK12448 1310161003521 Protein of unknown function (DUF2581); Region: DUF2581; pfam10756 1310161003522 Small-conductance mechanosensitive channel [Cell envelope biogenesis, outer membrane]; Region: MscS; COG0668 1310161003523 Mechanosensitive ion channel; Region: MS_channel; pfam00924 1310161003524 acetolactate synthase 1 catalytic subunit; Validated; Region: PRK07789 1310161003525 Pyrimidine (PYR) binding domain of POX and related proteins; Region: TPP_PYR_POX_like; cd07035 1310161003526 PYR/PP interface [polypeptide binding]; other site 1310161003527 dimer interface [polypeptide binding]; other site 1310161003528 TPP binding site [chemical binding]; other site 1310161003529 Thiamine pyrophosphate enzyme, central domain; Region: TPP_enzyme_M; pfam00205 1310161003530 Thiamine pyrophosphate (TPP) family, Acetohydroxyacid synthase (AHAS) subfamily, TPP-binding module; composed of proteins similar to the large catalytic subunit of AHAS. AHAS catalyzes the condensation of two molecules of pyruvate to give the...; Region: TPP_AHAS; cd02015 1310161003531 TPP-binding site [chemical binding]; other site 1310161003532 dimer interface [polypeptide binding]; other site 1310161003533 acetolactate synthase 3 regulatory subunit; Reviewed; Region: ilvH; PRK11895 1310161003534 N-terminal ACT domain of the Escherichia coli IlvH-like regulatory subunit of acetohydroxyacid synthase (AHAS); Region: ACT_AHAS; cd04878 1310161003535 putative valine binding site [chemical binding]; other site 1310161003536 dimer interface [polypeptide binding]; other site 1310161003537 Small subunit of acetolactate synthase; Region: ALS_ss_C; pfam10369 1310161003538 ketol-acid reductoisomerase; Provisional; Region: PRK05479 1310161003539 Acetohydroxy acid isomeroreductase, catalytic domain; Region: IlvN; pfam07991 1310161003540 Acetohydroxy acid isomeroreductase, catalytic domain; Region: IlvC; pfam01450 1310161003543 ABC-type nitrate/sulfonate/bicarbonate transport systems, periplasmic components [Inorganic ion transport and metabolism]; Region: TauA; COG0715 1310161003544 NMT1-like family; Region: NMT1_2; pfam13379 1310161003547 Flavin reductase like domain; Region: Flavin_Reduct; pfam01613 1310161003548 Co/Zn/Cd efflux system component [Inorganic ion transport and metabolism]; Region: CzcD; COG1230 1310161003549 Predicted Co/Zn/Cd cation transporters [Inorganic ion transport and metabolism]; Region: MMT1; COG0053 1310161003550 Uncharacterized conserved protein [Function unknown]; Region: COG1479 1310161003551 Protein of unknown function DUF262; Region: DUF262; pfam03235 1310161003552 Uncharacterized conserved protein [Function unknown]; Region: COG3472 1310161003553 Putative cell wall binding repeat 2; Region: CW_binding_2; pfam04122 1310161003554 D-3-phosphoglycerate dehydrogenase; Provisional; Region: PRK13581 1310161003555 Phosphoglycerate dehydrogenases, NAD-binding and catalytic domains; Region: PGDH_4; cd12173 1310161003556 ligand binding site [chemical binding]; other site 1310161003557 NAD binding site [chemical binding]; other site 1310161003558 dimerization interface [polypeptide binding]; other site 1310161003559 catalytic site [active] 1310161003560 C-terminal ACT (regulatory) domain of D-3-phosphoglycerate dehydrogenase (3PGDH); Region: ACT_3PGDH-xct; cd04902 1310161003561 putative L-serine binding site [chemical binding]; other site 1310161003562 Putative bacterial sensory transduction regulator; Region: YbjN; cl15834 1310161003563 3-isopropylmalate dehydrogenase; Provisional; Region: PRK03437 1310161003564 tartrate dehydrogenase; Region: TTC; TIGR02089 1310161003565 ABC-type nitrate/sulfonate/bicarbonate transport systems, periplasmic components [Inorganic ion transport and metabolism]; Region: TauA; COG0715 1310161003566 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 1310161003567 membrane-bound complex binding site; other site 1310161003568 hinge residues; other site 1310161003569 DNA polymerase III, epsilon subunit and related 3'-5' exonucleases [DNA replication, recombination, and repair]; Region: DnaQ; COG0847 1310161003570 DEDDh 3'-5' exonuclease domain family; Region: DEDDh; cd06127 1310161003571 active site 1310161003572 catalytic site [active] 1310161003573 substrate binding site [chemical binding]; other site 1310161003574 Domain of unknown function (DUF2437); Region: DUF2437; pfam10370 1310161003575 2-keto-4-pentenoate hydratase/2-oxohepta-3-ene-1,7-dioic acid hydratase (catechol pathway) [Secondary metabolites biosynthesis, transport, and catabolism]; Region: MhpD; COG0179 1310161003576 Fumarylacetoacetate (FAA) hydrolase family; Region: FAA_hydrolase; pfam01557 1310161003577 Methyltransferase domain; Region: Methyltransf_23; pfam13489 1310161003578 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 1310161003579 S-adenosylmethionine binding site [chemical binding]; other site 1310161003580 Isochorismate synthase [Coenzyme metabolism / Secondary metabolites biosynthesis, transport, and catabolism]; Region: MenF; COG1169 1310161003581 chorismate binding enzyme; Region: Chorismate_bind; pfam00425 1310161003582 glutamyl-tRNA synthetase; Reviewed; Region: gltX; PRK01406 1310161003583 catalytic core domain of discriminating glutamyl-tRNA synthetase; Region: GluRS_core; cd00808 1310161003584 active site 1310161003585 HIGH motif; other site 1310161003586 catalytic core domain of discriminating glutamyl-tRNA synthetase; Region: GluRS_core; cd00808 1310161003587 active site 1310161003588 KMSKS motif; other site 1310161003589 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 1310161003590 salt bridge; other site 1310161003591 non-specific DNA binding site [nucleotide binding]; other site 1310161003592 sequence-specific DNA binding site [nucleotide binding]; other site 1310161003593 Protein of unknown function (DUF3036); Region: DUF3036; pfam11234 1310161003594 Ligand-binding SRPBCC domain of an uncharacterized subfamily of proteins; Region: SRPBCC_4; cd07822 1310161003595 putative hydrophobic ligand binding site [chemical binding]; other site 1310161003596 Ligand-binding SRPBCC domain of an uncharacterized subfamily of proteins; Region: SRPBCC_4; cd07822 1310161003597 putative hydrophobic ligand binding site [chemical binding]; other site 1310161003598 START/RHO_alpha_C/PITP/Bet_v1/CoxG/CalC (SRPBCC) ligand-binding domain superfamily; Region: SRPBCC; cl14643 1310161003599 thiamine biosynthesis protein ThiC; Provisional; Region: PRK09284 1310161003600 ThiC-associated domain; Region: ThiC-associated; pfam13667 1310161003601 Thiamine biosynthesis protein ThiC [Coenzyme metabolism]; Region: ThiC; COG0422 1310161003602 glycogen/starch/alpha-glucan phosphorylases; Region: P_ylase; TIGR02093 1310161003603 This is a family of oligosaccharide phosphorylases. It includes yeast and mammalian glycogen phosphorylases, plant starch/glucan phosphorylase, as well as the maltodextrin phosphorylases of bacteria. The members of this family catalyze the breakdown of...; Region: GT1_Glycogen_Phosphorylase; cd04300 1310161003604 homodimer interface [polypeptide binding]; other site 1310161003605 active site pocket [active] 1310161003606 Zn-dependent hydrolases, including glyoxylases [General function prediction only]; Region: GloB; COG0491 1310161003607 Rhodanese Homology Domain (RHOD); an alpha beta fold domain found duplicated in the rhodanese protein. The cysteine containing enzymatically active version of the domain is also found in the Cdc25 class of protein phosphatases and a variety of proteins...; Region: RHOD; cd00158 1310161003608 active site residue [active] 1310161003609 Sulfite exporter TauE/SafE; Region: TauE; pfam01925 1310161003610 Guanosine polyphosphate pyrophosphohydrolases/synthetases [Signal transduction mechanisms / Transcription]; Region: SpoT; COG0317 1310161003611 HD domain; Region: HD_4; pfam13328 1310161003612 Transcriptional regulator [Transcription]; Region: IclR; COG1414 1310161003613 IclR helix-turn-helix domain; Region: HTH_IclR; pfam09339 1310161003614 Bacterial transcriptional regulator; Region: IclR; pfam01614 1310161003615 3-isopropylmalate dehydratase large subunit; Reviewed; Region: PRK00402 1310161003616 3-isopropylmalate dehydratase catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate; Region: IPMI; cd01583 1310161003617 substrate binding site [chemical binding]; other site 1310161003618 ligand binding site [chemical binding]; other site 1310161003619 isopropylmalate isomerase small subunit; Provisional; Region: leuD; PRK01641 1310161003620 Aconatase-like swivel domain of 3-isopropylmalate dehydratase and related uncharacterized proteins. 3-isopropylmalate dehydratase catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate...; Region: IPMI_Swivel; cd01577 1310161003621 substrate binding site [chemical binding]; other site 1310161003622 Diadenosine hexaphosphate (Ap6A) hydrolase is a member of the Nudix hydrolase superfamily. Ap6A hydrolase specifically hydrolyzes diadenosine polyphosphates, but not ATP or diadenosine triphosphate, and it generates ATP as the product. Ap6A, the most...; Region: Ap6A_hydrolase; cd03673 1310161003623 active site 1310161003624 Ap6A binding site [chemical binding]; other site 1310161003625 nudix motif; other site 1310161003626 metal binding site [ion binding]; metal-binding site 1310161003627 Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067 1310161003628 catalytic core [active] 1310161003629 NAD(P)H-dependent glycerol-3-phosphate dehydrogenase; Validated; Region: gpsA; PRK00094 1310161003630 NAD-dependent glycerol-3-phosphate dehydrogenase N-terminus; Region: NAD_Gly3P_dh_N; pfam01210 1310161003631 NAD-dependent glycerol-3-phosphate dehydrogenase C-terminus; Region: NAD_Gly3P_dh_C; pfam07479 1310161003632 D-alanyl-alanine synthetase A; Reviewed; Region: ddl; PRK01966 1310161003633 D-ala D-ala ligase N-terminus; Region: Dala_Dala_lig_N; pfam01820 1310161003634 ATP-grasp domain; Region: ATP-grasp_4; cl17255 1310161003635 Protein of unknown function (DUF3515); Region: DUF3515; pfam12028 1310161003636 Protein of unknown function (DUF3515); Region: DUF3515; pfam12028 1310161003637 thiamine monophosphate kinase; Provisional; Region: PRK05731 1310161003638 ThiL (Thiamine-monophosphate kinase) plays a dual role in de novo biosynthesis and in salvage of exogenous thiamine. Thiamine salvage occurs in two steps, with thiamine kinase catalyzing the formation of thiamine phosphate, and ThiL catalyzing the...; Region: ThiL; cd02194 1310161003639 ATP binding site [chemical binding]; other site 1310161003640 dimerization interface [polypeptide binding]; other site 1310161003641 Family 1 of Uracil-DNA glycosylase (UDG) enzymes; Region: UDG_F1; cd10027 1310161003642 ligand binding site [chemical binding]; other site 1310161003643 active site 1310161003644 UGI interface [polypeptide binding]; other site 1310161003645 catalytic site [active] 1310161003646 Predicted kinase related to dihydroxyacetone kinase [General function prediction only]; Region: COG1461 1310161003647 DAK2 domain; Region: Dak2; pfam02734 1310161003648 RecG-like helicase [DNA replication, recombination, and repair / Transcription]; Region: RecG; COG1200 1310161003649 RecG_wedge_OBF: A subfamily of OB folds corresponding to the OB fold found in the N-terminal (wedge) domain of Escherichia coli RecG. RecG is a branched-DNA-specific helicase, which catalyzes the interconversion of a DNA replication fork to a...; Region: RecG_wedge_OBF; cd04488 1310161003650 generic binding surface II; other site 1310161003651 ssDNA binding site; other site 1310161003652 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 1310161003653 ATP binding site [chemical binding]; other site 1310161003654 putative Mg++ binding site [ion binding]; other site 1310161003655 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 1310161003656 nucleotide binding region [chemical binding]; other site 1310161003657 ATP-binding site [chemical binding]; other site 1310161003658 Biotin carboxyl carrier protein [Lipid metabolism]; Region: AccB; COG0511 1310161003659 The biotinyl-domain or biotin carboxyl carrier protein (BCCP) domain is present in all biotin-dependent enzymes, such as acetyl-CoA carboxylase, pyruvate carboxylase, propionyl-CoA carboxylase, methylcrotonyl-CoA carboxylase, geranyl-CoA carboxylase; Region: biotinyl_domain; cd06850 1310161003660 carboxyltransferase (CT) interaction site; other site 1310161003661 biotinylation site [posttranslational modification]; other site 1310161003662 N6-adenine-specific methylase [DNA replication, recombination, and repair]; Region: COG0742 1310161003663 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 1310161003664 S-adenosylmethionine binding site [chemical binding]; other site 1310161003665 phosphopantetheine adenylyltransferase; Provisional; Region: coaD; PRK00168 1310161003666 Phosphopantetheine adenylyltransferase; Region: PPAT; cd02163 1310161003667 active site 1310161003668 (T/H)XGH motif; other site 1310161003669 ABC-type polar amino acid transport system, ATPase component [Amino acid transport and metabolism]; Region: GlnQ; COG1126 1310161003670 ATP-binding cassette domain of the histidine and glutamine transporters; Region: ABC_HisP_GlnQ; cd03262 1310161003671 Walker A/P-loop; other site 1310161003672 ATP binding site [chemical binding]; other site 1310161003673 Q-loop/lid; other site 1310161003674 ABC transporter signature motif; other site 1310161003675 Walker B; other site 1310161003676 D-loop; other site 1310161003677 H-loop/switch region; other site 1310161003678 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1310161003679 dimer interface [polypeptide binding]; other site 1310161003680 conserved gate region; other site 1310161003681 putative PBP binding loops; other site 1310161003682 ABC-ATPase subunit interface; other site 1310161003683 Protein of unknown function (DUF1266); Region: DUF1266; pfam06889 1310161003684 Domain of unknown function (DUF368); Region: DUF368; pfam04018 1310161003685 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1310161003686 Major Facilitator Superfamily; Region: MFS_1; pfam07690 1310161003687 putative substrate translocation pore; other site 1310161003688 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1310161003689 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 1310161003690 salt bridge; other site 1310161003691 non-specific DNA binding site [nucleotide binding]; other site 1310161003692 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 1310161003693 sequence-specific DNA binding site [nucleotide binding]; other site 1310161003694 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 1310161003695 Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248 1310161003696 active site 1310161003697 catalytic tetrad [active] 1310161003698 30S ribosomal protein S1; Reviewed; Region: rpsA; PRK07899 1310161003699 S1_RPS1_repeat_ec1_hs1: Ribosomal protein S1 (RPS1) domain. RPS1 is a component of the small ribosomal subunit thought to be involved in the recognition and binding of mRNA's during translation initiation. The bacterial RPS1 domain architecture...; Region: S1_RPS1_repeat_ec1_hs1; cd05687 1310161003700 RNA binding site [nucleotide binding]; other site 1310161003701 S1_RPS1_repeat_ec2_hs2: Ribosomal protein S1 (RPS1) domain. RPS1 is a component of the small ribosomal subunit thought to be involved in the recognition and binding of mRNA's during translation initiation. The bacterial RPS1 domain architecture...; Region: S1_RPS1_repeat_ec2_hs2; cd04465 1310161003702 RNA binding site [nucleotide binding]; other site 1310161003703 S1_like: Ribosomal protein S1-like RNA-binding domain. Found in a wide variety of RNA-associated proteins. Originally identified in S1 ribosomal protein. This superfamily also contains the Cold Shock Domain (CSD), which is a homolog of the S1 domain; Region: S1_like; cl09927 1310161003704 RNA binding site [nucleotide binding]; other site 1310161003705 S1 RNA binding domain; Region: S1; pfam00575 1310161003706 RNA binding site [nucleotide binding]; other site 1310161003707 PTS_IIB, PTS system, glucose/sucrose specific IIB subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIB_glc; cd00212 1310161003708 PTS system, beta-glucoside-specific IIABC component; Region: PTS-II-ABC-beta; TIGR01995 1310161003709 active site turn [active] 1310161003710 phosphorylation site [posttranslational modification] 1310161003711 Phosphotransferase system IIC components, glucose/maltose/N-acetylglucosamine-specific [Carbohydrate transport and metabolism]; Region: PtsG; COG1263 1310161003712 Phosphotransferase system IIA components [Carbohydrate transport and metabolism]; Region: NagE; COG2190 1310161003713 HPr interaction site; other site 1310161003714 glycerol kinase (GK) interaction site [polypeptide binding]; other site 1310161003715 active site 1310161003716 phosphorylation site [posttranslational modification] 1310161003717 Dephospho-CoA kinase [Coenzyme metabolism]; Region: CoaE; COG0237 1310161003718 Dephospho-coenzyme A kinase (DPCK, EC 2.7.1.24) catalyzes the phosphorylation of dephosphocoenzyme A (dCoA) to yield CoA, which is the final step in CoA biosynthesis; Region: DPCK; cd02022 1310161003719 CoA-binding site [chemical binding]; other site 1310161003720 ATP-binding [chemical binding]; other site 1310161003722 nuc_hydro_IU_UC_XIUA: inosine-uridine preferring, xanthosine-inosine-uridine-adenosine-preferring and, uridine-cytidine preferring nucleoside hydrolases. Nucleoside hydrolases cleave the N-glycosidic bond in nucleosides generating ribose and the...; Region: nuc_hydro_IU_UC_XIUA; cd02651 1310161003723 active site 1310161003724 tetramer interface [polypeptide binding]; other site 1310161003725 drug resistance transporter, EmrB/QacA subfamily; Region: efflux_EmrB; TIGR00711 1310161003726 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1310161003727 putative substrate translocation pore; other site 1310161003728 Sugar kinases, ribokinase family [Carbohydrate transport and metabolism]; Region: RbsK; COG0524 1310161003729 Ribokinase catalyses the phosphorylation of ribose to ribose-5-phosphate using ATP. This reaction is the first step in the ribose metabolism. It traps ribose within the cell after uptake and also prepares the sugar for use in the synthesis of nucleotides...; Region: ribokinase; cd01174 1310161003730 substrate binding site [chemical binding]; other site 1310161003731 dimer interface [polypeptide binding]; other site 1310161003732 ATP binding site [chemical binding]; other site 1310161003733 Transcriptional regulators [Transcription]; Region: PurR; COG1609 1310161003734 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 1310161003735 DNA binding site [nucleotide binding] 1310161003736 domain linker motif; other site 1310161003737 Ligand-binding domain of DNA-binding regulatory protein from Corynebacterium glutamicum which has a unique ability to produce significant amounts of L-glutamate directly from cheap sugar and ammonia; Region: PBP1_LacI_like_13; cd06299 1310161003738 dimerization interface [polypeptide binding]; other site 1310161003739 putative ligand binding site [chemical binding]; other site 1310161003740 excinuclease ABC subunit B; Provisional; Region: PRK05298 1310161003741 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 1310161003742 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 1310161003743 nucleotide binding region [chemical binding]; other site 1310161003744 ATP-binding site [chemical binding]; other site 1310161003745 Ultra-violet resistance protein B; Region: UvrB; pfam12344 1310161003746 UvrB/uvrC motif; Region: UVR; pfam02151 1310161003747 Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293 1310161003748 Ligand Binding Site [chemical binding]; other site 1310161003749 Predicted transcriptional regulators [Transcription]; Region: COG1733 1310161003750 HxlR-like helix-turn-helix; Region: HxlR; pfam01638 1310161003751 Predicted nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: COG0702 1310161003752 triphenylmethane reductase (TMR)-like proteins, NMRa-like, atypical (a) SDRs; Region: TMR_SDR_a; cd05269 1310161003753 NADP binding site [chemical binding]; other site 1310161003754 Superfamily I DNA and RNA helicases [General function prediction only]; Region: COG3973 1310161003755 Part of AAA domain; Region: AAA_19; pfam13245 1310161003756 Family description; Region: UvrD_C_2; pfam13538 1310161003757 Predicted membrane protein [Function unknown]; Region: COG2259 1310161003758 Zn-dependent hydrolases, including glyoxylases [General function prediction only]; Region: GloB; COG0491 1310161003759 excinuclease ABC subunit A; Reviewed; Region: uvrA; PRK00349 1310161003760 ATP-binding cassette domain I of the excision repair protein UvrA; Region: ABC_UvrA_I; cd03270 1310161003761 ATP-binding cassette domain I of the excision repair protein UvrA; Region: ABC_UvrA_I; cd03270 1310161003762 ATP-binding cassette domain II of the excision repair protein UvrA; Region: ABC_UvrA_II; cd03271 1310161003763 Predicted membrane protein (DUF2339); Region: DUF2339; pfam10101 1310161003764 Translation initiation factor IF-3, N-terminal domain; Region: IF3_N; pfam05198 1310161003765 translation initiation factor IF-3; Reviewed; Region: infC; PRK00028 1310161003766 Translation initiation factor IF-3, C-terminal domain; Region: IF3_C; pfam00707 1310161003767 50S ribosomal protein L35; Reviewed; Region: rpmI; PRK00172 1310161003768 Ribosomal protein L20; Region: Ribosomal_L20; cd07026 1310161003769 23S rRNA binding site [nucleotide binding]; other site 1310161003770 L21 binding site [polypeptide binding]; other site 1310161003771 L13 binding site [polypeptide binding]; other site 1310161003772 GIY-YIG domain of uncharacterized hypothetical protein found in bacteria; Region: GIY-YIG_unchar_1; cd10446 1310161003773 GIY-YIG motif/motif A; other site 1310161003774 putative active site [active] 1310161003775 putative metal binding site [ion binding]; other site 1310161003776 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1310161003777 dimer interface [polypeptide binding]; other site 1310161003778 conserved gate region; other site 1310161003779 putative PBP binding loops; other site 1310161003780 ABC-ATPase subunit interface; other site 1310161003781 ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395 1310161003782 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1310161003783 dimer interface [polypeptide binding]; other site 1310161003784 conserved gate region; other site 1310161003785 putative PBP binding loops; other site 1310161003786 ABC-ATPase subunit interface; other site 1310161003787 ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653 1310161003788 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; cl17199 1310161003789 glycerol-3-phosphate transporter ATP-binding subunit; Provisional; Region: ugpC; PRK11650 1310161003790 The N-terminal ATPase domain of the maltose transporter, MalK; Region: ABC_MalK_N; cd03301 1310161003791 Walker A/P-loop; other site 1310161003792 ATP binding site [chemical binding]; other site 1310161003793 Q-loop/lid; other site 1310161003794 ABC transporter signature motif; other site 1310161003795 Walker B; other site 1310161003796 D-loop; other site 1310161003797 H-loop/switch region; other site 1310161003798 TOBE domain; Region: TOBE_2; pfam08402 1310161003799 Glycerophosphoryl diester phosphodiesterase [Energy production and conversion]; Region: UgpQ; COG0584 1310161003800 Glycerophosphodiester phosphodiesterase domain as found in prokaryota and eukaryota, and similar proteins; Region: GDPD; cd08556 1310161003801 active site 1310161003802 catalytic site [active] 1310161003803 metal binding site [ion binding]; metal-binding site 1310161003804 rRNA methylases [Translation, ribosomal structure and biogenesis]; Region: SpoU; COG0566 1310161003805 RNA 2'-O ribose methyltransferase substrate binding; Region: SpoU_sub_bind; smart00967 1310161003806 SpoU rRNA Methylase family; Region: SpoU_methylase; pfam00588 1310161003807 phenylalanyl-tRNA synthetase subunit alpha; Validated; Region: pheS; PRK00488 1310161003808 Aminoacyl tRNA synthetase class II, N-terminal domain; Region: Phe_tRNA-synt_N; pfam02912 1310161003809 Phenylalanyl-tRNA synthetase (PheRS) alpha chain catalytic core domain. PheRS belongs to class II aminoacyl-tRNA synthetases (aaRS) based upon its structure and the presence of three characteristic sequence motifs. This domain is primarily responsible...; Region: PheRS_alpha_core; cd00496 1310161003810 dimer interface [polypeptide binding]; other site 1310161003811 motif 1; other site 1310161003812 active site 1310161003813 motif 2; other site 1310161003814 motif 3; other site 1310161003815 phenylalanyl-tRNA synthetase subunit beta; Reviewed; Region: pheT; PRK00629 1310161003816 tRNA-binding-domain-containing prokaryotic phenylalanly tRNA synthetase (PheRS) beta chain. PheRS aminoacylate phenylalanine transfer RNAs (tRNAphe). PheRSs belong structurally to class II aminoacyl tRNA synthetases (aaRSs) but, as they aminoacylate...; Region: tRNA_bind_bactPheRS; cd02796 1310161003817 putative tRNA-binding site [nucleotide binding]; other site 1310161003818 B3/4 domain; Region: B3_4; pfam03483 1310161003819 tRNA synthetase B5 domain; Region: B5; smart00874 1310161003820 Phenylalanyl-tRNA synthetase (PheRS) beta chain core domain. PheRS belongs to class II aminoacyl-tRNA synthetases (aaRS) based upon its structure. While class II aaRSs generally aminoacylate the 3'-OH ribose of the appropriate tRNA, PheRS is an...; Region: PheRS_beta_core; cd00769 1310161003821 dimer interface [polypeptide binding]; other site 1310161003822 motif 1; other site 1310161003823 motif 3; other site 1310161003824 motif 2; other site 1310161003825 Ferredoxin-fold anticodon binding domain; Region: FDX-ACB; pfam03147 1310161003826 SEST_like. A family of secreted SGNH-hydrolases similar to Streptomyces scabies esterase (SEST), a causal agent of the potato scab disease, which hydrolyzes a specific ester bond in suberin, a plant lipid. The tertiary fold of this enzyme is...; Region: SEST_like; cd01823 1310161003827 active site 1310161003828 catalytic triad [active] 1310161003829 oxyanion hole [active] 1310161003830 Predicted acyltransferases [Lipid metabolism]; Region: COG1835 1310161003831 N-acetyl-gamma-glutamyl-phosphate reductase; Validated; Region: argC; PRK00436 1310161003832 Semialdehyde dehydrogenase, NAD binding domain; Region: Semialdhyde_dh; smart00859 1310161003833 Ornithine acetyltransferase (OAT) family; also referred to as ArgJ. OAT catalyzes the first and fifth steps in arginine biosynthesis, coupling acetylation of glutamate with deacetylation of N-acetylornithine, which allows recycling of the acetyl group in...; Region: OAT; cd02152 1310161003834 heterotetramer interface [polypeptide binding]; other site 1310161003835 active site pocket [active] 1310161003836 cleavage site 1310161003837 AAK_NAGK-C: N-Acetyl-L-glutamate kinase - cyclic (NAGK-C) catalyzes the phosphorylation of the gamma-COOH group of N-acetyl-L-glutamate (NAG) by ATP in the second step of arginine biosynthesis found in some bacteria and photosynthetic organisms using the...; Region: AAK_NAGK-C; cd04250 1310161003838 feedback inhibition sensing region; other site 1310161003839 homohexameric interface [polypeptide binding]; other site 1310161003840 nucleotide binding site [chemical binding]; other site 1310161003841 N-acetyl-L-glutamate binding site [chemical binding]; other site 1310161003842 acetylornithine aminotransferase; Provisional; Region: argD; PRK03244 1310161003843 Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610 1310161003844 inhibitor-cofactor binding pocket; inhibition site 1310161003845 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1310161003846 catalytic residue [active] 1310161003847 ornithine carbamoyltransferase; Provisional; Region: PRK00779 1310161003848 Aspartate/ornithine carbamoyltransferase, carbamoyl-P binding domain; Region: OTCace_N; pfam02729 1310161003849 Aspartate/ornithine carbamoyltransferase, Asp/Orn binding domain; Region: OTCace; pfam00185 1310161003850 arginine repressor; Provisional; Region: PRK03341 1310161003851 Arginine repressor, DNA binding domain; Region: Arg_repressor; pfam01316 1310161003852 Arginine repressor, C-terminal domain; Region: Arg_repressor_C; pfam02863 1310161003853 argininosuccinate synthase; Provisional; Region: PRK13820 1310161003854 Argininosuccinate synthase. The Argininosuccinate synthase is a urea cycle enzyme that catalyzes the penultimate step in arginine biosynthesis: the ATP-dependent ligation of citrulline to aspartate to form argininosuccinate, AMP and pyrophosphate . In...; Region: Argininosuccinate_Synthase; cd01999 1310161003855 ANP binding site [chemical binding]; other site 1310161003856 Substrate Binding Site II [chemical binding]; other site 1310161003857 Substrate Binding Site I [chemical binding]; other site 1310161003858 argininosuccinate lyase; Provisional; Region: PRK00855 1310161003859 Argininosuccinate lyase (argininosuccinase, ASAL); Region: Argininosuccinate_lyase; cd01359 1310161003860 active sites [active] 1310161003861 tetramer interface [polypeptide binding]; other site 1310161003862 Uncharacterized protein containing a von Willebrand factor type A (vWA) domain [General function prediction only]; Region: COG2304 1310161003863 Von Willebrand factor type A (vWA) domain was originally found in the blood coagulation protein von Willebrand factor (vWF). Typically, the vWA domain is made up of approximately 200 amino acid residues folded into a classic a/b para-rossmann type of...; Region: vWFA; cl00057 1310161003864 metal ion-dependent adhesion site (MIDAS); other site 1310161003865 Uncharacterized conserved protein [Function unknown]; Region: COG2835 1310161003866 tyrosyl-tRNA synthetase; Validated; Region: PRK05912 1310161003867 catalytic core domain of tyrosinyl-tRNA synthetase; Region: TyrRS_core; cd00805 1310161003868 active site 1310161003869 HIGH motif; other site 1310161003870 dimer interface [polypeptide binding]; other site 1310161003871 KMSKS motif; other site 1310161003872 S4 RNA-binding domain; Region: S4; smart00363 1310161003873 RNA binding surface [nucleotide binding]; other site 1310161003874 Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293 1310161003875 Ligand Binding Site [chemical binding]; other site 1310161003876 Putative Zn-dependent protease, contains TPR repeats [General function prediction only]; Region: COG4783 1310161003877 Predicted sugar phosphatases of the HAD superfamily [Carbohydrate transport and metabolism]; Region: NagD; COG0647 1310161003878 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 1310161003879 active site 1310161003880 motif I; other site 1310161003881 motif II; other site 1310161003882 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 1310161003883 Predicted rRNA methylase [Translation, ribosomal structure and biogenesis]; Region: COG1189 1310161003884 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 1310161003885 RNA binding surface [nucleotide binding]; other site 1310161003886 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 1310161003887 S-adenosylmethionine binding site [chemical binding]; other site 1310161003888 inorganic polyphosphate/ATP-NAD kinase; Provisional; Region: ppnK; PRK03372 1310161003889 inorganic polyphosphate/ATP-NAD kinase; Provisional; Region: ppnK; PRK02231 1310161003890 ATPase involved in DNA repair [DNA replication, recombination, and repair]; Region: RecN; COG0497 1310161003891 ATP-binding cassette domain of RecN; Region: ABC_RecN; cd03241 1310161003892 Walker A/P-loop; other site 1310161003893 ATP binding site [chemical binding]; other site 1310161003894 Q-loop/lid; other site 1310161003895 ATP-binding cassette domain of RecN; Region: ABC_RecN; cd03241 1310161003896 ABC transporter signature motif; other site 1310161003897 Walker B; other site 1310161003898 D-loop; other site 1310161003899 H-loop/switch region; other site 1310161003900 Protein of unknown function (DUF3186); Region: DUF3186; pfam11382 1310161003901 CTP synthetase; Validated; Region: pyrG; PRK05380 1310161003902 CTP synthetase (CTPs) is a two-domain protein, which consists of an N-terminal synthetase domain and C-terminal glutaminase domain. The enzymes hydrolyze the amide bond of glutamine to ammonia and glutamate at the glutaminase domains and transfer nascent...; Region: CTGs; cd03113 1310161003903 Catalytic site [active] 1310161003904 active site 1310161003905 UTP binding site [chemical binding]; other site 1310161003906 Type 1 glutamine amidotransferase (GATase1) domain found in Cytidine Triphosphate Synthetase; Region: GATase1_CTP_Synthase; cd01746 1310161003907 active site 1310161003908 putative oxyanion hole; other site 1310161003909 catalytic triad [active] 1310161003910 ADP-ribose pyrophosphatase (ADPRase) catalyzes the hydrolysis of ADP-ribose and a variety of additional ADP-sugar conjugates to AMP and ribose-5-phosphate. Like other members of the Nudix hydrolase superfamily, it requires a divalent cation, such as Mg2+; Region: ADPRase_NUDT5; cd03424 1310161003911 dimer interface [polypeptide binding]; other site 1310161003912 ADP-ribose binding site [chemical binding]; other site 1310161003913 active site 1310161003914 nudix motif; other site 1310161003915 metal binding site [ion binding]; metal-binding site 1310161003916 site-specific tyrosine recombinase XerD; Reviewed; Region: xerD; PRK00283 1310161003917 XerD and XerC integrases, DNA breaking-rejoining enzymes, N- and C-terminal domains. XerD-like integrases are involved in the site-specific integration and excision of lysogenic bacteriophage genomes, transposition of conjugative transposons, termination...; Region: INT_XerDC; cd00798 1310161003918 active site 1310161003919 Int/Topo IB signature motif; other site 1310161003920 ATPase components of ABC transporters with duplicated ATPase domains [General function prediction only]; Region: Uup; COG0488 1310161003921 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 1310161003922 Walker A/P-loop; other site 1310161003923 ATP binding site [chemical binding]; other site 1310161003924 Q-loop/lid; other site 1310161003925 ABC transporter signature motif; other site 1310161003926 Walker B; other site 1310161003927 D-loop; other site 1310161003928 H-loop/switch region; other site 1310161003929 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 1310161003930 ATPases involved in chromosome partitioning [Cell division and chromosome partitioning]; Region: Soj; COG1192 1310161003931 ParA and ParB of Caulobacter crescentus belong to a conserved family of bacterial proteins implicated in chromosome segregation. ParB binds to DNA sequences adjacent to the origin of replication and localizes to opposite cell poles shortly following the...; Region: ParA; cd02042 1310161003932 P-loop; other site 1310161003933 Magnesium ion binding site [ion binding]; other site 1310161003934 ParA and ParB of Caulobacter crescentus belong to a conserved family of bacterial proteins implicated in chromosome segregation. ParB binds to DNA sequences adjacent to the origin of replication and localizes to opposite cell poles shortly following the...; Region: ParA; cd02042 1310161003935 Magnesium ion binding site [ion binding]; other site 1310161003936 Rec8/ScpA/Scc1-like protein (kleisin family) [Replication, recombination, and repair]; Region: scpA; COG1354 1310161003937 Acetyltransferase (GNAT) domain; Region: Acetyltransf_3; pfam13302 1310161003938 Rhodanese-related sulfurtransferase [Inorganic ion transport and metabolism]; Region: SseA; COG2897 1310161003939 Thiosulfate sulfurtransferase (TST), N-terminal, inactive domain. TST contains 2 copies of the Rhodanese Homology Domain; this is the 1st repeat, which does not contain the catalytically active Cys residue. The role of the 1st repeat is uncertain, but it...; Region: TST_Repeat_1; cd01448 1310161003940 active site residue [active] 1310161003941 Thiosulfate sulfurtransferase (TST), C-terminal, catalytic domain. TST contains 2 copies of the Rhodanese Homology Domain; this is the second repeat. Only the second repeat contains the catalytically active Cys residue; Region: TST_Repeat_2; cd01449 1310161003942 active site residue [active] 1310161003943 Putative transcriptional regulators (Ypuh-like); Region: DUF387; pfam04079 1310161003944 16S rRNA uridine-516 pseudouridylate synthase and related pseudouridylate synthases [Translation, ribosomal structure and biogenesis]; Region: RsuA; COG1187 1310161003945 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 1310161003946 RNA binding surface [nucleotide binding]; other site 1310161003947 Pseudouridine synthases, RsuA subfamily; Region: PseudoU_synth_RsuA_like; cd02870 1310161003948 active site 1310161003949 cytidylate kinase; Provisional; Region: cmk; PRK00023 1310161003950 Cytidine monophosphate kinase (CMPK) catalyzes the reversible phosphorylation of cytidine monophosphate (CMP) to produce cytidine diphosphate (CDP), using ATP as the preferred phosphoryl donor; Region: CMPK; cd02020 1310161003951 CMP-binding site; other site 1310161003952 The sites determining sugar specificity; other site 1310161003953 GTP-binding protein Der; Reviewed; Region: PRK03003 1310161003954 EngA1 GTPase contains the first domain of EngA; Region: EngA1; cd01894 1310161003955 G1 box; other site 1310161003956 GTP/Mg2+ binding site [chemical binding]; other site 1310161003957 Switch I region; other site 1310161003958 G2 box; other site 1310161003959 Switch II region; other site 1310161003960 G3 box; other site 1310161003961 G4 box; other site 1310161003962 G5 box; other site 1310161003963 EngA2 GTPase contains the second domain of EngA; Region: EngA2; cd01895 1310161003964 G1 box; other site 1310161003965 GTP/Mg2+ binding site [chemical binding]; other site 1310161003966 Switch I region; other site 1310161003967 G2 box; other site 1310161003968 G3 box; other site 1310161003969 Switch II region; other site 1310161003970 G4 box; other site 1310161003971 G5 box; other site 1310161003972 Pentapeptide repeats (9 copies); Region: Pentapeptide_4; pfam13599 1310161003973 Pentapeptide repeats (9 copies); Region: Pentapeptide_4; pfam13599 1310161003974 Transcriptional regulator, effector-binding domain/component [Transcription / Signal transduction mechanisms]; Region: COG4978 1310161003975 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 1310161003976 S-adenosylmethionine binding site [chemical binding]; other site 1310161003977 ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132 1310161003978 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 1310161003979 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 1310161003980 Walker A/P-loop; other site 1310161003981 ATP binding site [chemical binding]; other site 1310161003982 Q-loop/lid; other site 1310161003983 ABC transporter signature motif; other site 1310161003984 Walker B; other site 1310161003985 D-loop; other site 1310161003986 H-loop/switch region; other site 1310161003987 zinc transporter ZupT; Provisional; Region: PRK04201 1310161003988 NhaP-type Na+/H+ and K+/H+ antiporters [Inorganic ion transport and metabolism]; Region: NhaP; COG0025 1310161003989 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3012 1310161003990 SEC-C motif; Region: SEC-C; pfam02810 1310161003991 preprotein translocase subunit SecA; Reviewed; Region: PRK12326 1310161003992 SecA preprotein cross-linking domain; Region: SecA_PP_bind; pfam01043 1310161003993 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cl17351 1310161003994 nucleotide binding region [chemical binding]; other site 1310161003995 ATP-binding site [chemical binding]; other site 1310161003996 FOG: FHA domain [Signal transduction mechanisms]; Region: COG1716 1310161003997 Forkhead associated domain (FHA); found in eukaryotic and prokaryotic proteins. Putative nuclear signalling domain. FHA domains may bind phosphothreonine, phosphoserine and sometimes phosphotyrosine. In eukaryotes, many FHA domain-containing proteins...; Region: FHA; cd00060 1310161003998 phosphopeptide binding site; other site 1310161003999 Helix-Turn-Helix DNA binding domain of MerR-like transcription regulators; Region: HTH_MerR-like; cd00592 1310161004000 MerR HTH family regulatory protein; Region: MerR_1; pfam13411 1310161004001 DNA binding residues [nucleotide binding] 1310161004002 Uncharacterized conserved protein [Function unknown]; Region: COG1259 1310161004003 Helix-Turn-Helix DNA binding domain of transcription regulators from the MerR superfamily; Region: HTH_MerR-SF; cl02600 1310161004004 MerR HTH family regulatory protein; Region: MerR_1; pfam13411 1310161004005 DNA binding residues [nucleotide binding] 1310161004006 Domain of unknown function (DUF1707); Region: DUF1707; pfam08044 1310161004007 Hemolysins and related proteins containing CBS domains [General function prediction only]; Region: TlyC; COG1253 1310161004008 Domain of unknown function DUF21; Region: DUF21; pfam01595 1310161004009 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains associated with the CorC_HlyC domain. CorC_HlyC is a transporter associated domain. This small domain is found in Na+/H+ antiporters, in proteins involved in...; Region: CBS_pair_CorC_HlyC_assoc; cd04590 1310161004010 Hemolysins and related proteins containing CBS domains [General function prediction only]; Region: TlyC; COG1253 1310161004011 Domain of unknown function DUF21; Region: DUF21; pfam01595 1310161004012 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains associated with the CorC_HlyC domain. CorC_HlyC is a transporter associated domain. This small domain is found in Na+/H+ antiporters, in proteins involved in...; Region: CBS_pair_CorC_HlyC_assoc; cd04590 1310161004013 Transporter associated domain; Region: CorC_HlyC; smart01091 1310161004014 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cl17251 1310161004015 DEAD-like helicases superfamily; Region: DEXDc; smart00487 1310161004016 ATP binding site [chemical binding]; other site 1310161004017 putative Mg++ binding site [ion binding]; other site 1310161004018 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 1310161004019 nucleotide binding region [chemical binding]; other site 1310161004020 ATP-binding site [chemical binding]; other site 1310161004021 Siderophore-interacting protein [Inorganic ion transport and metabolism]; Region: ViuB; COG2375 1310161004022 Siderophore interacting proteins share the domain structure of the ferredoxin reductase like family. Siderophores are produced in various bacteria (and some plants) to extract iron from hosts. Binding constants are high, so iron can be pilfered from...; Region: siderophore_interacting; cd06193 1310161004023 FAD binding pocket [chemical binding]; other site 1310161004024 FAD binding motif [chemical binding]; other site 1310161004025 phosphate binding motif [ion binding]; other site 1310161004026 NAD binding pocket [chemical binding]; other site 1310161004027 6-phosphogluconate dehydrogenase-like protein; Reviewed; Region: PRK09599 1310161004028 6-phosphogluconate dehydrogenase; Validated; Region: PRK09287 1310161004029 6-phosphogluconate dehydrogenase, C-terminal domain; Region: 6PGD; pfam00393 1310161004030 PaaI_thioesterase is a tetrameric acyl-CoA thioesterase with a hot dog fold and one of several proteins responsible for phenylacetic acid (PA) degradation in bacteria. Although orthologs of PaaI exist in archaea and eukaryotes, their function has not...; Region: PaaI_thioesterase; cd03443 1310161004031 CoenzymeA binding site [chemical binding]; other site 1310161004032 subunit interaction site [polypeptide binding]; other site 1310161004033 PHB binding site; other site 1310161004034 Methyltransferase domain; Region: Methyltransf_31; pfam13847 1310161004035 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 1310161004036 S-adenosylmethionine binding site [chemical binding]; other site 1310161004037 ATP-binding cassette domain of the drug resistance transporter and related proteins, subfamily A; Region: ABC_DR_subfamily_A; cd03230 1310161004038 ABC-type cobalt transport system, ATPase component [Inorganic ion transport and metabolism]; Region: CbiO; COG1122 1310161004039 Walker A/P-loop; other site 1310161004040 ATP binding site [chemical binding]; other site 1310161004041 Q-loop/lid; other site 1310161004042 ABC transporter signature motif; other site 1310161004043 Walker B; other site 1310161004044 D-loop; other site 1310161004045 H-loop/switch region; other site 1310161004046 ABC-type multidrug transport system, permease component [Defense mechanisms]; Region: COG0842 1310161004047 ABC-2 type transporter; Region: ABC2_membrane; cl17235 1310161004048 Transcriptional regulators [Transcription]; Region: RpiR; COG1737 1310161004049 Helix-turn-helix domain, rpiR family; Region: HTH_6; pfam01418 1310161004050 RpiR-like protein. RpiR contains a SIS (Sugar ISomerase) domain, which is found in many phosphosugar isomerases and phosphosugar binding proteins. In E. coli, rpiR negatively regulates the expression of rpiB gene. Both rpiB and rpiA are ribose phosphate...; Region: SIS_RpiR; cd05013 1310161004051 putative active site [active] 1310161004052 phosphonate ABC transporter, permease protein PhnE; Region: PhnE; TIGR01097 1310161004053 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1310161004054 dimer interface [polypeptide binding]; other site 1310161004055 conserved gate region; other site 1310161004056 ABC-ATPase subunit interface; other site 1310161004057 phosphonate ABC transporter, permease protein PhnE; Region: PhnE; TIGR01097 1310161004058 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1310161004059 dimer interface [polypeptide binding]; other site 1310161004060 conserved gate region; other site 1310161004061 ABC-ATPase subunit interface; other site 1310161004062 ABC-type phosphate/phosphonate transport system, ATPase component [Inorganic ion transport and metabolism]; Region: COG3638 1310161004063 ATP-binding cassette domain of the binding protein-dependent phosphonate transport system; Region: ABC_PhnC_transporter; cd03256 1310161004064 Walker A/P-loop; other site 1310161004065 ATP binding site [chemical binding]; other site 1310161004066 Q-loop/lid; other site 1310161004067 ABC transporter signature motif; other site 1310161004068 Walker B; other site 1310161004069 D-loop; other site 1310161004070 H-loop/switch region; other site 1310161004071 ABC-type phosphate/phosphonate transport system, periplasmic component [Inorganic ion transport and metabolism]; Region: PhnD; COG3221 1310161004072 Predicted hydrolase (HAD superfamily) [General function prediction only]; Region: COG1011 1310161004073 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cl17915 1310161004074 motif I; other site 1310161004075 active site 1310161004076 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cl17915 1310161004077 motif II; other site 1310161004078 multifunctional thiamine-phosphate pyrophosphorylase/synthase/phosphomethylpyrimidine kinase; Provisional; Region: PRK09517 1310161004079 Thiamine monophosphate synthase (TMP synthase)/TenI. TMP synthase catalyzes an important step in the thiamine biosynthesis pathway, the substitution of the pyrophosphate of 2-methyl-4-amino-5- hydroxymethylpyrimidine pyrophosphate by 4-methyl-5-; Region: TMP_TenI; cd00564 1310161004080 thiamine phosphate binding site [chemical binding]; other site 1310161004081 active site 1310161004082 pyrophosphate binding site [ion binding]; other site 1310161004083 4-amino-5-hydroxymethyl-2-methyl-pyrimidine phosphate kinase (HMPP-kinase) catalyzes two consecutive phosphorylation steps in the thiamine phosphate biosynthesis pathway, leading to the synthesis of vitamin B1. The first step is the phosphorylation of...; Region: HMPP_kinase; cd01169 1310161004084 dimer interface [polypeptide binding]; other site 1310161004085 substrate binding site [chemical binding]; other site 1310161004086 ATP binding site [chemical binding]; other site 1310161004087 Putative transcription activator [Transcription]; Region: TenA; COG0819 1310161004088 4-methyl-5-beta-hydroxyethylthiazole (Thz) kinase catalyzes the phosphorylation of the hydroxylgroup of Thz. A reaction that allows cells to recycle Thz into the thiamine biosynthesis pathway, as an alternative to its synthesis from cysteine, tyrosine...; Region: THZ_kinase; cd01170 1310161004089 substrate binding site [chemical binding]; other site 1310161004090 multimerization interface [polypeptide binding]; other site 1310161004091 ATP binding site [chemical binding]; other site 1310161004092 NADH dehydrogenase, FAD-containing subunit [Energy production and conversion]; Region: Ndh; COG1252 1310161004093 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450 1310161004094 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 1310161004095 Cyclopropane fatty acid synthase and related methyltransferases [Cell envelope biogenesis, outer membrane]; Region: Cfa; COG2230 1310161004096 metabolite-proton symporter; Region: 2A0106; TIGR00883 1310161004097 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1310161004098 putative substrate translocation pore; other site 1310161004099 Predicted phosphoribosyltransferases [General function prediction only]; Region: COG2236 1310161004100 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 1310161004101 active site 1310161004102 Predicted membrane protein [Function unknown]; Region: COG1971 1310161004103 Domain of unknown function DUF; Region: DUF204; pfam02659 1310161004104 Domain of unknown function DUF; Region: DUF204; pfam02659 1310161004105 Arsenite efflux pump ACR3 and related permeases [Inorganic ion transport and metabolism]; Region: ACR3; COG0798 1310161004106 Sodium Bile acid symporter family; Region: SBF; cl17470 1310161004107 high affinity sulphate transporter 1; Region: sulP; TIGR00815 1310161004108 Sulfate transporter N-terminal domain with GLY motif; Region: Sulfate_tra_GLY; pfam13792 1310161004109 Sulfate transporter family; Region: Sulfate_transp; pfam00916 1310161004110 Sulphate Transporter and Anti-Sigma factor antagonist domain of SulP-like sulfate transporters, plays a role in the function and regulation of the transport activity, proposed general NTP binding function; Region: STAS_SulP_like_sulfate_transporter; cd07042 1310161004111 Uncharacterized protein potentially involved in peptidoglycan biosynthesis [Cell envelope biogenesis, outer membrane]; Region: COG5479 1310161004112 YceI-like domain; Region: YceI; cl01001 1310161004113 Domain of unknown function (DUF4109); Region: DUF4109; pfam13397 1310161004114 DPM1_like represents putative enzymes similar to eukaryotic DPM1; Region: DPM1_like; cd06442 1310161004115 Ligand binding site; other site 1310161004116 Putative Catalytic site; other site 1310161004117 DXD motif; other site 1310161004118 Apolipoprotein N-acyltransferase [Cell envelope biogenesis, outer membrane]; Region: Lnt; COG0815 1310161004119 Apolipoprotein N-acyl transferase (class 9 nitrilases); Region: ALP_N-acyl_transferase; cd07571 1310161004120 putative active site [active] 1310161004121 catalytic triad [active] 1310161004122 putative dimer interface [polypeptide binding]; other site 1310161004123 phage T7 F exclusion suppressor FxsA; Reviewed; Region: fxsA; PRK11463 1310161004124 Sulfite reductase, beta subunit (hemoprotein) [Inorganic ion transport and metabolism]; Region: CysI; COG0155 1310161004125 Nitrite/Sulfite reductase ferredoxin-like half domain; Region: NIR_SIR_ferr; pfam03460 1310161004128 Short-chain dehydrogenases of various substrate specificities [General function prediction only]; Region: DltE; COG0300 1310161004129 classical (c) SDRs; Region: SDR_c; cd05233 1310161004130 NAD(P) binding site [chemical binding]; other site 1310161004131 active site 1310161004132 Xaa-Pro aminopeptidase [Amino acid transport and metabolism]; Region: PepP; COG0006 1310161004133 Creatinase/Prolidase N-terminal domain; Region: Creatinase_N; pfam01321 1310161004134 Similar to Prolidase and Aminopeptidase P. The members of this subfamily presumably catalyse hydrolysis of Xaa-Pro dipeptides and/or release of any N-terminal amino acid, including proline, that is linked with proline; Region: APP-like; cd01092 1310161004135 active site 1310161004136 Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain [Posttranslational modification, protein turnover, chaperones]; Region: DegQ; COG0265 1310161004137 Trypsin-like peptidase domain; Region: Trypsin_2; pfam13365 1310161004138 Superfamily II RNA helicase [DNA replication, recombination, and repair]; Region: COG4581 1310161004139 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 1310161004140 ATP binding site [chemical binding]; other site 1310161004141 putative Mg++ binding site [ion binding]; other site 1310161004142 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 1310161004143 nucleotide binding region [chemical binding]; other site 1310161004144 ATP-binding site [chemical binding]; other site 1310161004145 DSHCT (NUC185) domain; Region: DSHCT; pfam08148 1310161004146 Sec-independent protein secretion pathway component TatC [Intracellular trafficking and secretion]; Region: TatC; COG0805 1310161004147 twin arginine translocase protein A; Provisional; Region: tatA; PRK00191 1310161004148 mttA/Hcf106 family; Region: MttA_Hcf106; pfam02416 1310161004149 Predicted transcriptional regulator [Transcription]; Region: COG2378 1310161004150 WYL domain; Region: WYL; pfam13280 1310161004151 Predicted transcriptional regulator [Transcription]; Region: COG2378 1310161004152 WYL domain; Region: WYL; pfam13280 1310161004153 proteasome accessory factor PafA; Region: pupylate_PafA; TIGR03686 1310161004154 Pup-like protein; Region: Pup; pfam05639 1310161004155 proteasome accessory factor PafA2; Region: pupylate_PafA2; TIGR03688 1310161004156 proteasome ATPase; Region: pup_AAA; TIGR03689 1310161004157 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 1310161004158 Walker A motif; other site 1310161004159 ATP binding site [chemical binding]; other site 1310161004160 Walker B motif; other site 1310161004161 arginine finger; other site 1310161004162 tRNA(1-methyladenosine) methyltransferase and related methyltransferases [Translation, ribosomal structure and biogenesis]; Region: GCD14; COG2519 1310161004163 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 1310161004164 M18 Peptidase Aspartyl aminopeptidase; Region: M18_DAP; cd05658 1310161004165 Aminopeptidase I zinc metalloprotease (M18); Region: Peptidase_M18; pfam02127 1310161004166 active site 1310161004167 metal binding site [ion binding]; metal-binding site 1310161004168 RecB family exonuclease [DNA replication, recombination, and repair]; Region: COG2887 1310161004169 Plasmid maintenance system antidote protein [General function prediction only]; Region: VapI; COG3093 1310161004170 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 1310161004171 non-specific DNA binding site [nucleotide binding]; other site 1310161004172 salt bridge; other site 1310161004173 sequence-specific DNA binding site [nucleotide binding]; other site 1310161004174 Major Facilitator Superfamily; Region: MFS_1; pfam07690 1310161004175 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1310161004176 putative substrate translocation pore; other site 1310161004177 aspartate ammonia-lyase; Provisional; Region: aspA; PRK12273 1310161004178 Aspartase; Region: Aspartase; cd01357 1310161004179 active sites [active] 1310161004180 tetramer interface [polypeptide binding]; other site 1310161004181 ATP phosphoribosyltransferase; Reviewed; Region: hisG; PRK00489 1310161004182 ATP phosphoribosyltransferase; Region: hisG; TIGR00070 1310161004183 ATP phosphoribosyltransferase, C-terminal domain; Region: HisG_C-term; TIGR03455 1310161004184 Nucleoside Triphosphate Pyrophosphohydrolase (EC 3.6.1.8) MazG-like domain found in Mycobacterium tuberculosis phosphoribosyl-ATP pyrophosphohydrolase (HisE or PRATP-PH) and its bacterial homologs; Region: NTP-PPase_HisE; cd11547 1310161004185 homodimer interface [polypeptide binding]; other site 1310161004186 putative metal binding site [ion binding]; other site 1310161004187 Predicted phosphatase/phosphohexomutase [General function prediction only]; Region: COG0637 1310161004188 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 1310161004189 motif II; other site 1310161004190 5-methyltetrahydrofolate--homocysteine methyltransferase; Region: metH; TIGR02082 1310161004191 Methionine synthase I (cobalamin-dependent), methyltransferase domain [Amino acid transport and metabolism]; Region: MetH; COG0646 1310161004192 Pterin binding enzymes. This family includes dihydropteroate synthase (DHPS) and cobalamin-dependent methyltransferases such as methyltetrahydrofolate, corrinoid iron-sulfur protein methyltransferase (MeTr) and methionine synthase (MetH). DHPS, a...; Region: Pterin_binding; cl00219 1310161004193 substrate binding pocket [chemical binding]; other site 1310161004194 dimer interface [polypeptide binding]; other site 1310161004195 inhibitor binding site; inhibition site 1310161004196 B12 binding domain of methionine synthase. This domain binds methylcobalamin, which it uses as an intermediate methyl carrier from methyltetrahydrofolate (CH3H4folate) to homocysteine (Hcy); Region: methionine_synthase_B12_BD; cd02069 1310161004197 B12 binding site [chemical binding]; other site 1310161004198 cobalt ligand [ion binding]; other site 1310161004199 Vitamin B12 dependent methionine synthase, activation domain; Region: Met_synt_B12; pfam02965 1310161004200 putative bacillithiol system oxidoreductase, YpdA family; Region: Bthiol_YpdA; TIGR04018 1310161004201 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox_3; pfam13738 1310161004202 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 1310161004203 dimerization interface [polypeptide binding]; other site 1310161004204 putative DNA binding site [nucleotide binding]; other site 1310161004205 putative Zn2+ binding site [ion binding]; other site 1310161004206 Arsenite efflux pump ACR3 and related permeases [Inorganic ion transport and metabolism]; Region: ACR3; COG0798 1310161004207 arsenical-resistance protein; Region: acr3; TIGR00832 1310161004208 Low molecular weight phosphatase family; Region: LMWPc; cl00105 1310161004209 Protein-tyrosine-phosphatase [Signal transduction mechanisms]; Region: Wzb; COG0394 1310161004210 active site 1310161004211 Protein-tyrosine-phosphatase [Signal transduction mechanisms]; Region: Wzb; COG0394 1310161004212 Low molecular weight phosphatase family; Region: LMWPc; cl00105 1310161004213 active site 1310161004214 cysteine--1-D-myo-inosityl 2-amino-2-deoxy-alpha-D-glucopyranoside ligase; Region: mycothiol_MshC; TIGR03447 1310161004215 nucleotidyl transferase superfamily; Region: nt_trans; cl00015 1310161004216 active site 1310161004217 HIGH motif; other site 1310161004218 nucleotide binding site [chemical binding]; other site 1310161004219 nucleotidyl transferase superfamily; Region: nt_trans; cl00015 1310161004220 active site 1310161004221 KMSKS motif; other site 1310161004222 Anticodon-binding domain of class Ia aminoacyl tRNA synthetases and similar domains; Region: Anticodon_Ia_like; cl12020 1310161004223 tRNA binding surface [nucleotide binding]; other site 1310161004224 anticodon binding site; other site 1310161004225 undecaprenyl pyrophosphate phosphatase; Reviewed; Region: PRK12554 1310161004226 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 1310161004227 active site 1310161004228 Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248 1310161004229 catalytic tetrad [active] 1310161004230 dihydroorotate dehydrogenase 2; Reviewed; Region: PRK05286 1310161004231 Dihydroorotate dehydrogenase (DHOD) class 2. DHOD catalyzes the oxidation of (S)-dihydroorotate to orotate. This is the fourth step and the only redox reaction in the de novo biosynthesis of UMP, the precursor of all pyrimidine nucleotides. DHOD requires...; Region: DHOD_2_like; cd04738 1310161004232 quinone interaction residues [chemical binding]; other site 1310161004233 active site 1310161004234 catalytic residues [active] 1310161004235 FMN binding site [chemical binding]; other site 1310161004236 substrate binding site [chemical binding]; other site 1310161004237 Integrase core domain; Region: rve; pfam00665 1310161004238 DDE domain; Region: DDE_Tnp_IS240; pfam13610 1310161004239 Integrase core domain; Region: rve_3; pfam13683 1310161004240 PhosphatidylEthanolamine-Binding Protein (PEBP) domain present in bacteria and archaea; Region: PEBP_bact_arch; cd00865 1310161004241 substrate binding site [chemical binding]; other site 1310161004242 ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132 1310161004243 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 1310161004244 Walker A/P-loop; other site 1310161004245 ATP binding site [chemical binding]; other site 1310161004246 Q-loop/lid; other site 1310161004247 ABC transporter signature motif; other site 1310161004248 Walker B; other site 1310161004249 D-loop; other site 1310161004250 H-loop/switch region; other site 1310161004251 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 1310161004252 Acetyltransferases [General function prediction only]; Region: RimI; COG0456 1310161004253 Coenzyme A binding pocket [chemical binding]; other site 1310161004254 membrane ATPase/protein kinase; Provisional; Region: PRK09435 1310161004255 The function of this protein family is unkown. The protein sequences are similar to the ArgK protein in E. coli. ArgK protein is a membrane ATPase which is required for transporting arginine, ornithine and lysine into the cells by the arginine and...; Region: ArgK-like; cd03114 1310161004256 Walker A; other site 1310161004257 methylmalonyl-CoA mutase; Reviewed; Region: PRK09426 1310161004258 Coenzyme B12-dependent-methylmalonyl coenzyme A (CoA) mutase (MCM) family, Alpha subunit-like subfamily; contains proteins similar to the alpha subunit of Propionbacterium shermanni MCM, as well as human and E. coli MCM. Members of this subfamily contain...; Region: MM_CoA_mutase_alpha_like; cd03679 1310161004259 active site 1310161004260 substrate binding site [chemical binding]; other site 1310161004261 coenzyme B12 binding site [chemical binding]; other site 1310161004262 methylmalonyl CoA mutase B12 binding domain. This domain binds to B12 (adenosylcobamide), which initiates the conversion of succinyl CoA and methylmalonyl CoA by forming an adenosyl radical, which then undergoes a rearrangement exchanging a hydrogen atom...; Region: MM_CoA_mut_B12_BD; cd02071 1310161004263 B12 binding site [chemical binding]; other site 1310161004264 cobalt ligand [ion binding]; other site 1310161004265 methylmalonyl-CoA mutase, heterodimeric type, beta chain; Region: mmCoA_mut_beta; TIGR00642 1310161004266 Coenzyme B12-dependent-methylmalonyl coenzyme A (CoA) mutase (MCM) family, Beta subunit-like subfamily; contains bacterial proteins similar to the beta subunit of MCMs from Propionbacterium shermanni and Streptomyces cinnamonensis, which are alpha/beta...; Region: MM_CoA_mutase_beta; cd03677 1310161004267 heterodimer interface [polypeptide binding]; other site 1310161004268 substrate interaction site [chemical binding]; other site 1310161004269 Methylmalonyl-CoA mutase, C-terminal domain/subunit (cobalamin-binding) [Lipid metabolism]; Region: Sbm; COG2185 1310161004270 Uncharacterized conserved protein [Function unknown]; Region: COG0398 1310161004271 SNARE associated Golgi protein; Region: SNARE_assoc; pfam09335 1310161004272 Membrane protease subunits, stomatin/prohibitin homologs [Posttranslational modification, protein turnover, chaperones]; Region: HflC; COG0330 1310161004273 Band_7_stomatin_like: A subgroup of the band 7 domain of flotillin (reggie) like proteins similar to stomatin and podicin (two lipid raft-associated integral membrane proteins). Individual proteins of this band 7 domain family may cluster to form...; Region: Band_7_stomatin_like; cd03403 1310161004274 Membrane protein implicated in regulation of membrane protease activity [Posttranslational modification, protein turnover, chaperones / Intracellular trafficking and secretion]; Region: COG1585 1310161004275 Protein of unknown function (DUF3097); Region: DUF3097; pfam11296 1310161004276 ferrochelatase; Reviewed; Region: hemH; PRK00035 1310161004277 Ferrochelatase, N-terminal domain: Ferrochelatase (protoheme ferrolyase or HemH) is the terminal enzyme of the heme biosynthetic pathway. It catalyzes the insertion of ferrous iron into the protoporphyrin IX ring yielding protoheme. This enzyme is...; Region: Ferrochelatase_N; cd03411 1310161004278 C-terminal domain interface [polypeptide binding]; other site 1310161004279 active site 1310161004280 Ferrochelatase, C-terminal domain: Ferrochelatase (protoheme ferrolyase or HemH) is the terminal enzyme of the heme biosynthetic pathway. It catalyzes the insertion of ferrous iron into the protoporphyrin IX ring yielding protoheme. This enzyme is...; Region: Ferrochelatase_C; cd00419 1310161004281 active site 1310161004282 N-terminal domain interface [polypeptide binding]; other site 1310161004283 aconitate hydratase; Validated; Region: PRK09277 1310161004284 Aconitase catalytic domain; Aconitase catalyzes the reversible isomerization of citrate and isocitrate as part of the TCA cycle; Region: Aconitase; cl00285 1310161004285 substrate binding site [chemical binding]; other site 1310161004286 Aconitase catalytic domain; Aconitase catalyzes the reversible isomerization of citrate and isocitrate as part of the TCA cycle; Region: Aconitase; cl00285 1310161004287 ligand binding site [chemical binding]; other site 1310161004288 Aconitase A swivel domain. This is the major form of the TCA cycle enzyme aconitate hydratase, also known as aconitase and citrate hydro-lyase. It includes bacterial and archaeal aconitase A, and the eukaryotic cytosolic form of aconitase. This group...; Region: AcnA_IRP_Swivel; cd01580 1310161004289 substrate binding site [chemical binding]; other site 1310161004290 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 1310161004291 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 1310161004292 GMP synthase - Glutamine amidotransferase domain [Nucleotide transport and metabolism]; Region: GuaA; COG0518 1310161004293 Subgroup of proteins having the Type 1 glutamine amidotransferase (GATase1) domain; Region: GATase1_1; cd01741 1310161004294 catalytic triad [active] 1310161004295 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 1310161004296 NADH(P)-binding; Region: NAD_binding_10; pfam13460 1310161004297 NAD(P) binding site [chemical binding]; other site 1310161004298 active site 1310161004299 Uncharacterized proteins with similarity to Ribonucleotide reductase and Pyruvate formate lyase; Region: RNR_PFL_like_DUF711; cd08025 1310161004300 Cation transport ATPase [Inorganic ion transport and metabolism]; Region: MgtA; COG0474 1310161004301 Cation transporter/ATPase, N-terminus; Region: Cation_ATPase_N; smart00831 1310161004302 E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122 1310161004303 Putative hydrolase of sodium-potassium ATPase alpha subunit; Region: Hydrolase_like2; pfam13246 1310161004304 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 1310161004305 motif II; other site 1310161004306 Cation transporting ATPase, C-terminus; Region: Cation_ATPase_C; pfam00689 1310161004307 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4762 1310161004308 ATPase components of ABC transporters with duplicated ATPase domains [General function prediction only]; Region: Uup; COG0488 1310161004309 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 1310161004310 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 1310161004311 Walker A/P-loop; other site 1310161004312 ATP binding site [chemical binding]; other site 1310161004313 Q-loop/lid; other site 1310161004314 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 1310161004315 ABC transporter signature motif; other site 1310161004316 Walker B; other site 1310161004317 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 1310161004318 NPCBM-associated, NEW3 domain of alpha-galactosidase; Region: NPCBM_assoc; pfam10633 1310161004319 Arrestin (or S-antigen), C-terminal domain; Region: Arrestin_C; cl02844 1310161004320 Sialidases or neuraminidases function to bind and hydrolyze terminal sialic acid residues from various glycoconjugates as well as playing roles in pathogenesis, bacterial nutrition and cellular interactions. They have a six-bladed, beta-propeller fold...; Region: Sialidase; cd00260 1310161004321 catalytic site [active] 1310161004322 BNR repeat-like domain; Region: BNR_2; pfam13088 1310161004323 Asp-box motif; other site 1310161004324 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3316 1310161004325 Integrase core domain; Region: rve; pfam00665 1310161004326 Predicted metal-sulfur cluster biosynthetic enzyme [General function prediction only]; Region: PaaD; COG2151 1310161004327 NifU homolog involved in Fe-S cluster formation [Energy production and conversion]; Region: IscU; COG0822 1310161004328 Iron-sulfur cluster scaffold-like proteins; Region: IscU_like; cd06664 1310161004329 trimerization site [polypeptide binding]; other site 1310161004330 active site 1310161004331 Selenocysteine lyase/Cysteine desulfurase [Posttranslational modification, protein turnover, chaperones]; Region: csdA; COG0520 1310161004332 Cysteine desulfurase (SufS)-like. This family belongs to the pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to cysteine desulfurase (SufS) and selenocysteine lyase. SufS...; Region: SufS_like; cd06453 1310161004333 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 1310161004334 catalytic residue [active] 1310161004335 Cysteine desulfurase activator ATPase [Posttranslational modification, protein turnover, chaperones]; Region: sufC; COG0396 1310161004336 ABC-type transport system involved in Fe-S cluster assembly, ATPase component; Region: ABC_FeS_Assembly; cd03217 1310161004337 Walker A/P-loop; other site 1310161004338 ATP binding site [chemical binding]; other site 1310161004339 Q-loop/lid; other site 1310161004340 ABC transporter signature motif; other site 1310161004341 Walker B; other site 1310161004342 D-loop; other site 1310161004343 H-loop/switch region; other site 1310161004344 Cysteine desulfurase activator SufB [Posttranslational modification, protein turnover, chaperones]; Region: SufB; COG0719 1310161004345 FeS assembly protein SufD; Region: sufD; TIGR01981 1310161004346 cysteine desulfurase activator complex subunit SufB; Provisional; Region: PRK11814; cl03223 1310161004347 FeS assembly protein SufB; Region: sufB; TIGR01980 1310161004348 Predicted transcriptional regulator [Transcription]; Region: COG2345 1310161004349 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 1310161004350 putative DNA binding site [nucleotide binding]; other site 1310161004351 putative Zn2+ binding site [ion binding]; other site 1310161004352 ABC-type multidrug transport system, ATPase component [Defense mechanisms]; Region: CcmA; COG1131 1310161004353 ATP-binding cassette domain of the drug resistance transporter and related proteins, subfamily A; Region: ABC_DR_subfamily_A; cd03230 1310161004354 Walker A/P-loop; other site 1310161004355 ATP binding site [chemical binding]; other site 1310161004356 Q-loop/lid; other site 1310161004357 ABC transporter signature motif; other site 1310161004358 Walker B; other site 1310161004359 D-loop; other site 1310161004360 H-loop/switch region; other site 1310161004361 ABC-2 type transporter; Region: ABC2_membrane; cl17235 1310161004362 ABC-2 family transporter protein; Region: ABC2_membrane_3; pfam12698 1310161004363 Uncharacterized protein required for cytochrome oxidase assembly [Posttranslational modification, protein turnover, chaperones]; Region: CtaA; COG1612 1310161004364 Cytochrome oxidase assembly protein; Region: COX15-CtaA; pfam02628 1310161004365 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4951 1310161004366 DNA or RNA helicases of superfamily II [Transcription / DNA replication, recombination, and repair]; Region: SSL2; COG1061 1310161004367 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 1310161004368 ATP binding site [chemical binding]; other site 1310161004369 putative Mg++ binding site [ion binding]; other site 1310161004370 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 1310161004371 nucleotide binding region [chemical binding]; other site 1310161004372 ATP-binding site [chemical binding]; other site 1310161004373 Transketolase [Carbohydrate transport and metabolism]; Region: TktA; COG0021 1310161004374 Thiamine pyrophosphate (TPP) family, Transketolase (TK) subfamily, TPP-binding module; TK catalyzes the transfer of a two-carbon unit from ketose phosphates to aldose phosphates. In heterotrophic organisms, TK provides a link between glycolysis and the...; Region: TPP_TK; cd02012 1310161004375 TPP-binding site [chemical binding]; other site 1310161004376 dimer interface [polypeptide binding]; other site 1310161004377 Pyrimidine (PYR) binding domain of 1-deoxy-D-xylulose-5-phosphate synthase (DXS), transketolase (TK), and related proteins; Region: TPP_PYR_DXS_TK_like; cd07033 1310161004378 PYR/PP interface [polypeptide binding]; other site 1310161004379 dimer interface [polypeptide binding]; other site 1310161004380 TPP binding site [chemical binding]; other site 1310161004381 Transaldolase-like proteins from plants and bacteria; Region: Transaldolase_like; cd00955 1310161004382 putative active site [active] 1310161004383 transaldolase; Provisional; Region: PRK03903 1310161004384 catalytic residue [active] 1310161004385 glucose-6-phosphate 1-dehydrogenase; Validated; Region: PRK05722 1310161004386 Glucose-6-phosphate dehydrogenase, NAD binding domain; Region: G6PD_N; pfam00479 1310161004387 Glucose-6-phosphate dehydrogenase, C-terminal domain; Region: G6PD_C; pfam02781 1310161004388 glucose-6-phosphate dehydrogenase assembly protein OpcA; Region: OpcA; TIGR00534 1310161004389 Glucose-6-P dehydrogenase subunit [Carbohydrate transport and metabolism]; Region: COG3429 1310161004390 6-phosphogluconolactonase/Glucosamine-6-phosphate isomerase/deaminase [Carbohydrate transport and metabolism]; Region: NagB; COG0363 1310161004391 6PGL: 6-Phosphogluconolactonase (6PGL) subfamily; 6PGL catalyzes the second step of the oxidative phase of the pentose phosphate pathway, the hydrolyzation of 6-phosphoglucono-1,5-lactone (delta form) to 6-phosphogluconate. 6PGL is thought to guard...; Region: 6PGL; cd01400 1310161004392 putative active site [active] 1310161004394 Transposase DDE domain; Region: DDE_Tnp_1; pfam01609 1310161004396 ornithine cyclodeaminase; Validated; Region: PRK06199 1310161004397 Ornithine cyclodeaminase/mu-crystallin family; Region: OCD_Mu_crystall; pfam02423 1310161004398 ammonium transporter; Region: amt; TIGR00836 1310161004399 Preprotein translocase SecG subunit; Region: SecG; cl09123 1310161004400 phosphoenolpyruvate carboxylase; Reviewed; Region: PRK00009 1310161004401 Phosphoenolpyruvate carboxylase [Energy production and conversion]; Region: Ppc; COG2352 1310161004402 triosephosphate isomerase; Provisional; Region: PRK14567 1310161004403 Triosephosphate isomerase (TIM) is a glycolytic enzyme that catalyzes the interconversion of dihydroxyacetone phosphate and D-glyceraldehyde-3-phosphate. The reaction is very efficient and requires neither cofactors nor metal ions. TIM, usually...; Region: TIM; cd00311 1310161004404 substrate binding site [chemical binding]; other site 1310161004405 dimer interface [polypeptide binding]; other site 1310161004406 catalytic triad [active] 1310161004407 Phosphoglycerate kinase; Region: PGK; pfam00162 1310161004408 Phosphoglycerate kinase (PGK) is a monomeric enzyme which catalyzes the transfer of the high-energy phosphate group of 1,3-bisphosphoglycerate to ADP, forming ATP and 3-phosphoglycerate. This reaction represents the first of the two substrate-level...; Region: Phosphoglycerate_kinase; cd00318 1310161004409 substrate binding site [chemical binding]; other site 1310161004410 hinge regions; other site 1310161004411 ADP binding site [chemical binding]; other site 1310161004412 catalytic site [active] 1310161004413 Glyceraldehyde-3-phosphate dehydrogenase/erythrose-4-phosphate dehydrogenase [Carbohydrate transport and metabolism]; Region: GapA; COG0057 1310161004414 Glyceraldehyde 3-phosphate dehydrogenase, NAD binding domain; Region: Gp_dh_N; pfam00044 1310161004415 Glyceraldehyde 3-phosphate dehydrogenase, C-terminal domain; Region: Gp_dh_C; pfam02800 1310161004416 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG1481 1310161004417 Sporulation Regulator WhiA N terminal; Region: WhiA_N; pfam10298 1310161004418 family of mostly uncharacterized proteins similar to B.subtilis YvcK; Region: YvcK_like; cd07187 1310161004419 Uncharacterized protein family UPF0052; Region: UPF0052; pfam01933 1310161004420 phosphate binding site [ion binding]; other site 1310161004421 putative substrate binding pocket [chemical binding]; other site 1310161004422 dimer interface [polypeptide binding]; other site 1310161004423 Predicted P-loop-containing kinase [General function prediction only]; Region: COG1660 1310161004424 excinuclease ABC subunit C; Validated; Region: uvrC; PRK00558 1310161004425 Catalytic GIY-YIG domain of nucleotide excision repair endonucleases UvrC, Cho, and similar proteins; Region: GIY-YIG_UvrC_Cho; cd10434 1310161004426 GIY-YIG motif/motif A; other site 1310161004427 active site 1310161004428 catalytic site [active] 1310161004429 putative DNA binding site [nucleotide binding]; other site 1310161004430 metal binding site [ion binding]; metal-binding site 1310161004431 UvrB/uvrC motif; Region: UVR; pfam02151 1310161004432 UvrC Helix-hairpin-helix N-terminal; Region: UvrC_HhH_N; pfam08459 1310161004433 Protein of unknown function (DUF2581); Region: DUF2581; pfam10756 1310161004434 lumazine synthase (6,7-dimethyl-8-ribityllumazine synthase, LS), catalyzes the penultimate step in the biosynthesis of riboflavin (vitamin B2); type-I; Region: Lumazine_synthase-I; cd09209 1310161004435 homopentamer interface [polypeptide binding]; other site 1310161004436 active site 1310161004437 bifunctional 3,4-dihydroxy-2-butanone 4-phosphate synthase/GTP cyclohydrolase II protein; Provisional; Region: PRK09311 1310161004438 3,4-dihydroxy-2-butanone 4-phosphate synthase; Region: DHBP_synthase; pfam00926 1310161004439 GTP cyclohydrolase II (RibA). GTP cyclohydrolase II catalyzes the conversion of GTP to 2,5-diamino-6-ribosylamino-4(3H)-pyrimidinone 5' phosphate, formate, pyrophosphate (APy), and GMP in the biosynthetic pathway of riboflavin. Riboflavin is the...; Region: GTP_cyclohydro2; cd00641 1310161004440 dimerization interface [polypeptide binding]; other site 1310161004441 active site 1310161004442 riboflavin synthase subunit alpha; Provisional; Region: PRK09289 1310161004443 Lumazine binding domain; Region: Lum_binding; pfam00677 1310161004444 Lumazine binding domain; Region: Lum_binding; pfam00677 1310161004445 riboflavin biosynthesis protein RibD; Region: eubact_ribD; TIGR00326 1310161004446 Riboflavin-specific deaminase. Riboflavin biosynthesis protein RibD (Diaminohydroxyphosphoribosylaminopyrimidine deaminase) catalyzes the deamination of 2,5-diamino-6-ribosylamino-4(3H)-pyrimidinone 5'-phosphate, which is an intermediate step in the...; Region: Riboflavin_deaminase-reductase; cd01284 1310161004447 catalytic motif [active] 1310161004448 Zn binding site [ion binding]; other site 1310161004449 RibD C-terminal domain; Region: RibD_C; pfam01872 1310161004450 Pentose-5-phosphate-3-epimerase [Carbohydrate transport and metabolism]; Region: Rpe; COG0036 1310161004451 Ribulose-5-phosphate 3-epimerase (RPE). This enzyme catalyses the interconversion of D-ribulose 5-phosphate (Ru5P) into D-xylulose 5-phosphate, as part of the Calvin cycle (reductive pentose phosphate pathway) in chloroplasts and in the oxidative pentose...; Region: RPE; cd00429 1310161004452 substrate binding site [chemical binding]; other site 1310161004453 hexamer interface [polypeptide binding]; other site 1310161004454 metal binding site [ion binding]; metal-binding site 1310161004455 16S rRNA methyltransferase B; Provisional; Region: PRK14902 1310161004456 RNA binding domain of NusB (N protein-Utilization Substance B) and Sun (also known as RrmB or Fmu) proteins. This family includes two orthologous groups exemplified by the transcription termination factor NusB and the N-terminal domain of the...; Region: NusB_Sun; cl00223 1310161004457 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 1310161004458 S-adenosylmethionine binding site [chemical binding]; other site 1310161004459 methionyl-tRNA formyltransferase; Reviewed; Region: fmt; PRK00005 1310161004460 Methionyl-tRNA formyltransferase, N-terminal hydrolase domain; Region: FMT_core_Met-tRNA-FMT_N; cd08646 1310161004461 putative active site [active] 1310161004462 substrate binding site [chemical binding]; other site 1310161004463 putative cosubstrate binding site; other site 1310161004464 catalytic site [active] 1310161004465 C-terminal domain of Formyltransferase and other enzymes; Region: Met_tRNA_FMT_C; cd08704 1310161004466 substrate binding site [chemical binding]; other site 1310161004467 Polypeptide or peptide deformylase; a family of metalloenzymes that catalyzes the removal of the N-terminal formyl group in a growing polypeptide chain following translation initiation during protein synthesis in prokaryotes. These enzymes utilize Fe(II)...; Region: Pep_deformylase; cd00487 1310161004468 active site 1310161004469 catalytic residues [active] 1310161004470 metal binding site [ion binding]; metal-binding site 1310161004471 primosome assembly protein PriA; Provisional; Region: PRK14873 1310161004472 S-adenosylmethionine synthetase; Validated; Region: PRK05250 1310161004473 S-adenosylmethionine synthetase, N-terminal domain; Region: S-AdoMet_synt_N; pfam00438 1310161004474 S-adenosylmethionine synthetase, central domain; Region: S-AdoMet_synt_M; pfam02772 1310161004475 S-adenosylmethionine synthetase, C-terminal domain; Region: S-AdoMet_synt_C; pfam02773 1310161004476 DNA-directed RNA polymerase, subunit K/omega [Transcription]; Region: RpoZ; COG1758 1310161004477 Guanylate kinase [Nucleotide transport and metabolism]; Region: Gmk; COG0194 1310161004478 Guanosine monophosphate kinase (GMPK, EC 2.7.4.8), also known as guanylate kinase (GKase), catalyzes the reversible phosphoryl transfer from adenosine triphosphate (ATP) to guanosine monophosphate (GMP) to yield adenosine diphosphate (ADP) and guanosine...; Region: GMPK; cd00071 1310161004479 catalytic site [active] 1310161004480 G-X2-G-X-G-K; other site 1310161004481 Orotidine 5'-phosphate decarboxylase (ODCase) is a dimeric enzyme that decarboxylates orotidine 5'-monophosphate (OMP) to form uridine 5'-phosphate (UMP), an essential step in the pyrimidine biosynthetic pathway. In mammals, UMP synthase...; Region: OMP_decarboxylase_like; cd04725 1310161004482 active site 1310161004483 dimer interface [polypeptide binding]; other site 1310161004484 carbamoyl phosphate synthase large subunit; Reviewed; Region: carB; PRK05294 1310161004485 Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289 1310161004486 ATP-grasp domain; Region: ATP-grasp_4; cl17255 1310161004487 Carbamoyl-phosphate synthetase large chain, oligomerisation domain; Region: CPSase_L_D3; pfam02787 1310161004488 Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289 1310161004489 ATP-grasp domain; Region: ATP-grasp_4; cl17255 1310161004490 Methylglyoxal synthase-like domain from type II glutamine-dependent carbamoyl phosphate synthetase (CSP). CSP, a CarA and CarB heterodimer, catalyzes the production of carbamoyl phosphate which is subsequently employed in the metabolic pathways...; Region: MGS_CPS_II; cd01424 1310161004491 IMP binding site; other site 1310161004492 dimer interface [polypeptide binding]; other site 1310161004493 interdomain contacts; other site 1310161004494 partial ornithine binding site; other site 1310161004495 carbamoyl phosphate synthase small subunit; Reviewed; Region: PRK12564 1310161004496 Carbamoyl-phosphate synthase small chain, CPSase domain; Region: CPSase_sm_chain; smart01097 1310161004497 Small chain of the glutamine-dependent form of carbamoyl phosphate synthase, CPSase II; Region: GATase1_CPSase; cd01744 1310161004498 catalytic site [active] 1310161004499 subunit interface [polypeptide binding]; other site 1310161004500 dihydroorotase; Validated; Region: pyrC; PRK09357 1310161004501 Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281 1310161004502 Dihydroorotase (DHOase), subgroup IIa; DHOases catalyze the reversible interconversion of carbamoyl aspartate to dihydroorotate, a key reaction in pyrimidine biosynthesis. This subgroup also contains proteins that lack the active site, like unc-33, a C; Region: DHOase_IIa; cd01317 1310161004503 active site 1310161004504 aspartate carbamoyltransferase catalytic subunit; Provisional; Region: pyrB; PRK00856 1310161004505 Aspartate/ornithine carbamoyltransferase, carbamoyl-P binding domain; Region: OTCace_N; pfam02729 1310161004506 Aspartate/ornithine carbamoyltransferase, Asp/Orn binding domain; Region: OTCace; pfam00185 1310161004507 Pyrimidine operon attenuation protein/uracil phosphoribosyltransferase [Nucleotide transport and metabolism]; Region: PyrR; COG2065 1310161004508 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 1310161004509 active site 1310161004510 Putative bacterial sensory transduction regulator; Region: YbjN; pfam10722 1310161004511 Putative bacterial sensory transduction regulator; Region: YbjN; pfam10722 1310161004512 Transcription termination factor [Transcription]; Region: NusB; COG0781 1310161004513 putative RNA binding site [nucleotide binding]; other site 1310161004514 elongation factor P; Validated; Region: PRK00529 1310161004515 Elongation factor P (EF-P) KOW-like domain; Region: EFP_N; pfam08207 1310161004516 S1_EF-P_repeat_1: Translation elongation factor P (EF-P), S1-like RNA-binding domain, repeat 1. EF-P stimulates the peptidyltransferase activity in the prokaryotic 70S ribosome. EF-P enhances the synthesis of certain dipeptides with...; Region: S1_EF-P_repeat_1; cd04470 1310161004517 RNA binding site [nucleotide binding]; other site 1310161004518 S1_EF-P_repeat_2: Translation elongation factor P (EF-P), S1-like RNA-binding domain, repeat 1. EF-P stimulates the peptidyltransferase activity in the prokaryotic 70S ribosome. EF-P enhances the synthesis of certain dipeptides with...; Region: S1_EF-P_repeat_2; cd05794 1310161004519 RNA binding site [nucleotide binding]; other site 1310161004520 Xaa-Pro aminopeptidase [Amino acid transport and metabolism]; Region: PepP; COG0006 1310161004521 Creatinase/Prolidase N-terminal domain; Region: Creatinase_N; pfam01321 1310161004522 Similar to Prolidase and Aminopeptidase P. The members of this subfamily presumably catalyse hydrolysis of Xaa-Pro dipeptides and/or release of any N-terminal amino acid, including proline, that is linked with proline; Region: APP-like; cd01092 1310161004523 active site 1310161004524 Dehydroquinate synthase (DHQS) catalyzes the conversion of DAHP to DHQ in shikimate pathway for aromatic compounds synthesis; Region: DHQS; cd08195 1310161004525 active site 1310161004526 dimer interface [polypeptide binding]; other site 1310161004527 metal binding site [ion binding]; metal-binding site 1310161004528 shikimate kinase; Reviewed; Region: aroK; PRK00131 1310161004529 Shikimate kinase (SK) is the fifth enzyme in the shikimate pathway, a seven-step biosynthetic pathway which converts erythrose-4-phosphate to chorismic acid, found in bacteria, fungi and plants. Chorismic acid is a important intermediate in the synthesis...; Region: SK; cd00464 1310161004530 ADP binding site [chemical binding]; other site 1310161004531 magnesium binding site [ion binding]; other site 1310161004532 putative shikimate binding site; other site 1310161004533 Type II secretory pathway, prepilin signal peptidase PulO and related peptidases [Cell motility and secretion / Posttranslational modification, protein turnover, chaperones / Intracellular trafficking and secretion]; Region: PulO; COG1989 1310161004534 Type IV leader peptidase family; Region: Peptidase_A24; pfam01478 1310161004535 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 1310161004536 dimerization interface [polypeptide binding]; other site 1310161004537 putative DNA binding site [nucleotide binding]; other site 1310161004538 putative Zn2+ binding site [ion binding]; other site 1310161004539 iron-hydroxamate transporter permease subunit; Provisional; Region: PRK10577 1310161004540 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550 1310161004541 ABC-ATPase subunit interface; other site 1310161004542 dimer interface [polypeptide binding]; other site 1310161004543 putative PBP binding regions; other site 1310161004544 ABC-type Fe3+-hydroxamate transport system, periplasmic component [Inorganic ion transport and metabolism]; Region: FepB; COG0614 1310161004545 Metal binding protein TroA_a. These proteins are predicted to function as initial receptors in ABC transport of metal ions in eubacteria. They belong to the TroA superfamily of helical backbone metal receptor proteins that share a distinct fold and...; Region: TroA_a; cd01148 1310161004546 putative ligand binding residues [chemical binding]; other site 1310161004547 ABC-type cobalamin/Fe3+-siderophores transport systems, ATPase components [Inorganic ion transport and metabolism / Coenzyme metabolism]; Region: FepC; COG1120 1310161004548 ATP-binding component of iron-siderophores, vitamin B12 and hemin transporters and related proteins; Region: ABC_Iron-Siderophores_B12_Hemin; cd03214 1310161004549 Walker A/P-loop; other site 1310161004550 ATP binding site [chemical binding]; other site 1310161004551 Q-loop/lid; other site 1310161004552 ABC transporter signature motif; other site 1310161004553 Walker B; other site 1310161004554 D-loop; other site 1310161004555 H-loop/switch region; other site 1310161004556 shikimate 5-dehydrogenase; Reviewed; Region: aroE; PRK00258 1310161004557 Shikimate dehydrogenase substrate binding domain; Region: Shikimate_dh_N; pfam08501 1310161004558 NAD(P) binding domain of Shikimate dehydrogenase; Region: NAD_bind_Shikimate_DH; cd01065 1310161004559 shikimate binding site; other site 1310161004560 NAD(P) binding site [chemical binding]; other site 1310161004561 YceG-like family; Region: YceG; pfam02618 1310161004562 proteins similar to Escherichia coli yceG; Region: yceG_like; cd08010 1310161004563 dimerization interface [polypeptide binding]; other site 1310161004564 Holliday junction resolvase-like protein; Reviewed; Region: PRK00109 1310161004565 alanyl-tRNA synthetase; Reviewed; Region: alaS; PRK00252 1310161004566 Alanyl-tRNA synthetase (AlaRS) class II core catalytic domain. AlaRS is a homodimer. It is responsible for the attachment of alanine to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for ATP-dependent...; Region: AlaRS_core; cd00673 1310161004567 motif 1; other site 1310161004568 active site 1310161004569 motif 2; other site 1310161004570 motif 3; other site 1310161004571 Threonyl and Alanyl tRNA synthetase second additional domain; Region: tRNA_SAD; smart00863 1310161004572 recombination factor protein RarA; Reviewed; Region: PRK13342 1310161004573 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 1310161004574 Walker A motif; other site 1310161004575 ATP binding site [chemical binding]; other site 1310161004576 Walker B motif; other site 1310161004577 MgsA AAA+ ATPase C terminal; Region: MgsA_C; pfam12002 1310161004578 Aminoglycoside 3'-phosphotransferase (APH) and Choline Kinase (ChoK) family. The APH/ChoK family is part of a larger superfamily that includes the catalytic domains of other kinases, such as the typical serine/threonine/tyrosine protein kinases (PKs)...; Region: APH_ChoK_like; cl17270 1310161004579 aspartyl-tRNA synthetase; Validated; Region: aspS; PRK00476 1310161004580 EcAspRS_like_N: N-terminal, anticodon recognition domain of the type found in Escherichia coli aspartyl-tRNA synthetase (AspRS), the human mitochondrial (mt) AspRS-2, the discriminating (D) Thermus thermophilus AspRS-1, and the nondiscriminating (ND)...; Region: EcAspRS_like_N; cd04317 1310161004581 dimer interface [polypeptide binding]; other site 1310161004582 anticodon binding site; other site 1310161004583 Asp tRNA synthetase (aspRS) class II core domain. Class II assignment is based upon its structure and the presence of three characteristic sequence motifs. AspRS is a homodimer, which attaches a specific amino acid to the 3' OH group of ribose of...; Region: AspRS_core; cd00777 1310161004584 homodimer interface [polypeptide binding]; other site 1310161004585 motif 1; other site 1310161004586 active site 1310161004587 motif 2; other site 1310161004588 GAD domain; Region: GAD; pfam02938 1310161004589 Class II tRNA amino-acyl synthetase-like catalytic core domain. Class II amino acyl-tRNA synthetases (aaRS) share a common fold and generally attach an amino acid to the 3' OH of ribose of the appropriate tRNA. PheRS is an exception in that it...; Region: class_II_aaRS-like_core; cl00268 1310161004590 active site 1310161004591 motif 3; other site 1310161004592 Predicted metalloprotease [General function prediction only]; Region: COG2321 1310161004593 Putative neutral zinc metallopeptidase; Region: Zn_peptidase; pfam04228 1310161004594 YhgE/Pip N-terminal domain; Region: pip_yhgE_Nterm; TIGR03061 1310161004595 Predicted membrane protein [Function unknown]; Region: COG1511 1310161004596 X-X-X-Leu-X-X-Gly heptad repeats; Region: xxxLxxG_by_4; TIGR03057 1310161004597 X-X-X-Leu-X-X-Gly heptad repeats; Region: xxxLxxG_by_4; TIGR03057 1310161004598 YhgE/Pip C-terminal domain; Region: pip_yhgE_Cterm; TIGR03062 1310161004599 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 1310161004600 Q-loop/lid; other site 1310161004601 ABC transporter signature motif; other site 1310161004602 Walker B; other site 1310161004603 D-loop; other site 1310161004604 H-loop/switch region; other site 1310161004605 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 1310161004606 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 1310161004607 putative luciferase-like monooxygenase, FMN-dependent, CE1758 family; Region: LLM_CE1758_fam; TIGR04036 1310161004608 Flavin-utilizing monoxygenases; Region: Flavin_utilizing_monoxygenases; cl07892 1310161004609 N5,N10-methylenetetrahydromethanopterin reductase (Mer) catalyzes the reduction of N5,N10-methylenetetrahydromethanopterin with reduced coenzyme F420 to N5-methyltetrahydromethanopterin and oxidized coenzyme F420; Region: Tetrahydromethanopterin_reductase; cd01097 1310161004610 Flavodoxin-like fold; Region: Flavodoxin_2; cl00438 1310161004611 LLM-partnered FMN reductase, CE1759 family; Region: LLM_duo_CE1759; TIGR04037 1310161004612 NADPH-dependent FMN reductase; Region: FMN_red; pfam03358 1310161004613 L-serine dehydratase, iron-sulfur-dependent, single chain form; Region: sda_mono; TIGR00720 1310161004614 Serine dehydratase beta chain; Region: SDH_beta; pfam03315 1310161004615 Serine dehydratase alpha chain; Region: SDH_alpha; pfam03313 1310161004616 Glycerol-3-phosphate dehydrogenase [Energy production and conversion]; Region: GlpA; COG0578 1310161004617 histidyl-tRNA synthetase; Reviewed; Region: hisS; PRK00037 1310161004618 Class II Histidinyl-tRNA synthetase (HisRS)-like catalytic core domain. HisRS is a homodimer. It is responsible for the attachment of histidine to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for...; Region: HisRS-like_core; cd00773 1310161004619 dimer interface [polypeptide binding]; other site 1310161004620 motif 1; other site 1310161004621 active site 1310161004622 motif 2; other site 1310161004623 motif 3; other site 1310161004624 HisRS Histidyl-anticodon binding domain. HisRS belongs to class II aminoacyl-tRNA synthetases (aaRS). This alignment contains the anticodon binding domain, which is responsible for specificity in tRNA-binding, so that the activated amino acid is...; Region: HisRS_anticodon; cd00859 1310161004625 anticodon binding site; other site 1310161004626 Metallo-beta-lactamase superfamily; Region: Lactamase_B; smart00849 1310161004627 cyclophilin: cyclophilin-type peptidylprolyl cis- trans isomerases. This family contains eukaryotic, bacterial and archeal proteins which exhibit a peptidylprolyl cis- trans isomerases activity (PPIase, Rotamase) and in addition bind the...; Region: cyclophilin; cd00317 1310161004628 active site 1310161004629 Guanosine polyphosphate pyrophosphohydrolases/synthetases [Signal transduction mechanisms / Transcription]; Region: SpoT; COG0317 1310161004630 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 1310161004631 Zn2+ binding site [ion binding]; other site 1310161004632 Mg2+ binding site [ion binding]; other site 1310161004633 Nucleotidyltransferase (NT) domain of RelA- and SpoT-like ppGpp synthetases and hydrolases; Region: NT_Rel-Spo_like; cd05399 1310161004634 synthetase active site [active] 1310161004635 NTP binding site [chemical binding]; other site 1310161004636 metal binding site [ion binding]; metal-binding site 1310161004637 TGS_RelA_SpoT: The RelA (SpoT) protein, also referred to as ppGpp hydrolase/synthetase, is a ribosome-associated protein that is activated during amino acid starvation and thought to mediate the stringent response. RelA contains a TGS domain, named after...; Region: TGS_RelA_SpoT; cd01668 1310161004638 ACT domain found C-terminal of the RelA/SpoT domains; Region: ACT_RelA-SpoT; cd04876 1310161004639 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 1310161004640 active site 1310161004641 ABC-type dipeptide transport system, periplasmic component [Amino acid transport and metabolism]; Region: DdpA; COG0747 1310161004642 The substrate-binding domain of an ABC-type nickel/oligopeptide-like import system contains the type 2 periplasmic binding fold; Region: PBP2_NikA_DppA_OppA_like; cl01709 1310161004643 preprotein translocase subunit SecF; Reviewed; Region: secF; PRK13022 1310161004644 Protein export membrane protein; Region: SecD_SecF; cl14618 1310161004645 Preprotein translocase subunit SecD [Intracellular trafficking and secretion]; Region: SecD; COG0342 1310161004646 Protein export membrane protein; Region: SecD_SecF; cl14618 1310161004647 Preprotein translocase subunit; Region: YajC; pfam02699 1310161004648 Holliday junction DNA helicase RuvB; Reviewed; Region: ruvB; PRK00080 1310161004649 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 1310161004650 Walker A motif; other site 1310161004651 ATP binding site [chemical binding]; other site 1310161004652 Walker B motif; other site 1310161004653 arginine finger; other site 1310161004654 Holliday junction DNA helicase ruvB C-terminus; Region: RuvB_C; pfam05491 1310161004655 Holliday junction resolvasome, DNA-binding subunit [DNA replication, recombination, and repair]; Region: RuvA; COG0632 1310161004656 RuvA N terminal domain; Region: RuvA_N; pfam01330 1310161004657 RuvA, C-terminal domain; Region: RuvA_C; pfam07499 1310161004658 Holliday junction resolvases (HJRs) are endonucleases that specifically resolve Holliday junction DNA intermediates during homologous recombination. HJR's occur in archaea, bacteria, and in the mitochondria of certain fungi, however this CD...; Region: RuvC_resolvase; cd00529 1310161004659 active site 1310161004660 putative DNA-binding cleft [nucleotide binding]; other site 1310161004661 dimer interface [polypeptide binding]; other site 1310161004662 hypothetical protein; Validated; Region: PRK00110 1310161004663 Acyl-CoA thioesterase [Lipid metabolism]; Region: TesB; COG1946 1310161004664 Thioesterase II (TEII) is thought to regenerate misprimed nonribosomal peptide synthetases (NRPSs) as well as modular polyketide synthases (PKSs) by hydrolyzing acetyl groups bound to the peptidyl carrier protein (PCP) and acyl carrier protein (ACP)...; Region: Thioesterase_II_repeat2; cd03445 1310161004665 active site 1310161004666 Thioesterase II (TEII) is thought to regenerate misprimed nonribosomal peptide synthetases (NRPSs) as well as modular polyketide synthases (PKSs) by hydrolyzing acetyl groups bound to the peptidyl carrier protein (PCP) and acyl carrier protein (ACP)...; Region: Thioesterase_II_repeat1; cd03444 1310161004667 catalytic triad [active] 1310161004668 dimer interface [polypeptide binding]; other site 1310161004669 Domain of unknown function (DUF3817); Region: DUF3817; pfam12823 1310161004670 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 1310161004671 This family is most closely related to the GT1 family of glycosyltransferases and named after YqgM in Bacillus licheniformis about which little is known. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to...; Region: GT1_YqgM_like; cd03801 1310161004672 Bacterial lipid A biosynthesis acyltransferase; Region: Lip_A_acyltrans; pfam03279 1310161004673 Lysophospholipid acyltransferases (LPLATs) of glycerophospholipid biosynthesis; Region: LPLAT; cl17185 1310161004674 Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: LABLAT-like; Region: LPLAT_LABLAT-like; cd07984 1310161004675 putative acyl-acceptor binding pocket; other site 1310161004676 Phosphatidylglycerophosphate synthase [Lipid metabolism]; Region: PgsA; COG0558 1310161004677 FHIT (fragile histidine family): FHIT proteins, related to the HIT family carry a motif HxHxH/Qxx (x, is a hydrophobic amino acid), On the basis of sequence, substrate specificity, structure, evolution and mechanism, HIT proteins are classified into...; Region: FHIT; cd01275 1310161004678 nucleotide binding site/active site [active] 1310161004679 HIT family signature motif; other site 1310161004680 catalytic residue [active] 1310161004681 threonyl-tRNA synthetase; Reviewed; Region: thrS; PRK12305 1310161004682 Threonyl and Alanyl tRNA synthetase second additional domain; Region: tRNA_SAD; pfam07973 1310161004683 Threonyl-tRNA synthetase (ThrRS) class II core catalytic domain. ThrRS is a homodimer. It is responsible for the attachment of threonine to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for ATP-dependent...; Region: ThrRS_core; cd00771 1310161004684 active site 1310161004685 dimer interface [polypeptide binding]; other site 1310161004686 motif 1; other site 1310161004687 motif 2; other site 1310161004688 motif 3; other site 1310161004689 ThrRS Threonyl-anticodon binding domain. ThrRS belongs to class II aminoacyl-tRNA synthetases (aaRS). This alignment contains the anticodon binding domain, which is responsible for specificity in tRNA-binding, so that the activated amino acid is...; Region: ThrRS_anticodon; cd00860 1310161004690 anticodon binding site; other site 1310161004691 Predicted iron-dependent peroxidase [Inorganic ion transport and metabolism]; Region: COG2837 1310161004692 Copper(I)-binding protein [Inorganic ion transport and metabolism]; Region: COG2847 1310161004693 Uncharacterized protein, homolog of Cu resistance protein CopC [General function prediction only]; Region: CopC; COG2372 1310161004694 Di- and tricarboxylate transporters [Inorganic ion transport and metabolism]; Region: CitT; COG0471 1310161004695 Anion permease ArsB/NhaD. These permeases have been shown to translocate sodium, arsenate, antimonite, sulfate and organic anions across biological membranes in all three kingdoms of life. A typical anion permease contains 8-13 transmembrane helices...; Region: ArsB_NhaD_permease; cl17221 1310161004696 Glycerate kinase [Carbohydrate transport and metabolism]; Region: COG1929 1310161004697 hypothetical protein; Provisional; Region: PRK14059 1310161004698 Pyrimidine reductase, riboflavin biosynthesis [Coenzyme metabolism]; Region: RibD; COG1985 1310161004699 Protein of unknown function (DUF2029); Region: DUF2029; pfam09594 1310161004700 Conserved domain frequently associated with peptide methionine sulfoxide reductase [Posttranslational modification, protein turnover, chaperones]; Region: COG0229 1310161004701 SelR domain; Region: SelR; pfam01641 1310161004702 Predicted heme peroxidase involved in anaerobic stress response [General function prediction only]; Region: ywfI; COG3253 1310161004703 Protein of unknown function (DUF3000); Region: DUF3000; pfam11452 1310161004704 Ribonuclease D [Translation, ribosomal structure and biogenesis]; Region: Rnd; COG0349 1310161004705 DEDDy 3'-5' exonuclease domain of Ribonuclease D and similar proteins; Region: RNaseD_exo; cd06142 1310161004706 catalytic site [active] 1310161004707 putative active site [active] 1310161004708 putative substrate binding site [chemical binding]; other site 1310161004709 HRDC domain; Region: HRDC; pfam00570 1310161004710 Deoxyxylulose-5-phosphate synthase [Coenzyme metabolism / Lipid metabolism]; Region: Dxs; COG1154 1310161004711 Thiamine pyrophosphate (TPP) family, DXS subfamily, TPP-binding module; 1-Deoxy-D-xylulose-5-phosphate synthase (DXS) is a regulatory enzyme of the mevalonate-independent pathway involved in terpenoid biosynthesis. Terpeniods are plant natural products...; Region: TPP_DXS; cd02007 1310161004712 TPP-binding site; other site 1310161004713 Pyrimidine (PYR) binding domain of 1-deoxy-D-xylulose-5-phosphate synthase (DXS), transketolase (TK), and related proteins; Region: TPP_PYR_DXS_TK_like; cd07033 1310161004714 PYR/PP interface [polypeptide binding]; other site 1310161004715 dimer interface [polypeptide binding]; other site 1310161004716 TPP binding site [chemical binding]; other site 1310161004717 Transketolase, C-terminal domain; Region: Transketolase_C; pfam02780 1310161004718 TRAM domain; Region: TRAM; pfam01938 1310161004719 SAM-dependent methyltransferases related to tRNA (uracil-5-)-methyltransferase [Translation, ribosomal structure and biogenesis]; Region: TrmA; COG2265 1310161004720 Protein of unknown function (DUF3710); Region: DUF3710; pfam12502 1310161004721 Trimeric dUTP diphosphatases; Region: trimeric_dUTPase; cd07557 1310161004722 trimer interface [polypeptide binding]; other site 1310161004723 active site 1310161004724 Protein of unknown function (DUF3093); Region: DUF3093; pfam11292 1310161004725 Domain of unknown function (DUF4193); Region: DUF4193; pfam13834 1310161004726 Archaeal fructose-1,6-bisphosphatase and related enzymes of inositol monophosphatase family [Carbohydrate transport and metabolism]; Region: SuhB; COG0483 1310161004727 IMPase, inositol monophosphatase and related domains. A family of Mg++ dependent phosphatases, inhibited by lithium, many of which may act on inositol monophosphate substrate. They dephosphorylate inositol phosphate to generate inositol, which may be...; Region: IMPase; cd01639 1310161004728 active site 1310161004729 dimerization interface [polypeptide binding]; other site 1310161004730 Transcriptional regulator/sugar kinase [Transcription / Carbohydrate transport and metabolism]; Region: NagC; COG1940 1310161004731 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cl17037 1310161004732 RNA polymerase sigma factor SigB; Reviewed; Region: PRK07921 1310161004733 Sigma-70 factor, region 1.2; Region: Sigma70_r1_2; pfam00140 1310161004734 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 1310161004735 Sigma-70 region 3; Region: Sigma70_r3; pfam04539 1310161004736 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 1310161004737 DNA binding residues [nucleotide binding] 1310161004738 Predicted membrane protein [Function unknown]; Region: COG2311 1310161004739 Protein of unknown function (DUF418); Region: DUF418; cl12135 1310161004740 Protein of unknown function (DUF418); Region: DUF418; pfam04235 1310161004741 DNA or RNA helicases of superfamily II [Transcription / DNA replication, recombination, and repair]; Region: SSL2; COG1061 1310161004742 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 1310161004743 ATP binding site [chemical binding]; other site 1310161004744 putative Mg++ binding site [ion binding]; other site 1310161004745 Protein of unknown function (DUF3039); Region: DUF3039; pfam11238 1310161004746 Protein of unknown function (DUF3099); Region: DUF3099; pfam11298 1310161004747 Methylase of polypeptide chain release factors [Translation, ribosomal structure and biogenesis]; Region: HemK; COG2890 1310161004748 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 1310161004749 S-adenosylmethionine binding site [chemical binding]; other site 1310161004750 D-Tyrosyl-tRNAtyr deacylases; a class of tRNA-dependent hydrolases which are capable of hydrolyzing the ester bond of D-Tyrosyl-tRNA reducing the level of cellular D-Tyrosine while recycling the peptidyl-tRNA; found in bacteria and in eukaryotes but not...; Region: Dtyr_deacylase; cd00563 1310161004751 putative active site [active] 1310161004752 dimerization interface [polypeptide binding]; other site 1310161004753 putative tRNAtyr binding site [nucleotide binding]; other site 1310161004754 RNA polymerase sigma factor SigB; Reviewed; Region: PRK07921 1310161004755 Sigma-70 factor, region 1.2; Region: Sigma70_r1_2; pfam00140 1310161004756 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 1310161004757 Sigma-70 region 3; Region: Sigma70_r3; pfam04539 1310161004758 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 1310161004759 DNA binding residues [nucleotide binding] 1310161004760 Iron dependent repressor, N-terminal DNA binding domain; Region: Fe_dep_repress; pfam01325 1310161004761 Helix-turn-helix diphteria tox regulatory element; Region: HTH_DTXR; smart00529 1310161004762 Iron dependent repressor, metal binding and dimerisation domain; Region: Fe_dep_repr_C; pfam02742 1310161004763 This entry represents the core domain of the ferrous iron (Fe2+) transport protein FeoA found in bacteria; Region: FeoA; smart00899 1310161004764 UDP-glucose 4-epimerase [Cell envelope biogenesis, outer membrane]; Region: GalE; COG1087 1310161004765 UDP-glucose 4 epimerase, subgroup 1, extended (e) SDRs; Region: UDP_G4E_1_SDR_e; cd05247 1310161004766 NAD binding site [chemical binding]; other site 1310161004767 homodimer interface [polypeptide binding]; other site 1310161004768 active site 1310161004769 substrate binding site [chemical binding]; other site 1310161004770 PAC2 family; Region: PAC2; pfam09754 1310161004771 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 1310161004772 DNA-binding transcriptional regulator OxyR; Provisional; Region: PRK11151 1310161004773 The C-terminal substrate-binding domain of the LysR-type transcriptional regulator OxyR, a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_OxyR; cd08411 1310161004774 dimerization interface [polypeptide binding]; other site 1310161004775 Predicted integral membrane protein [Function unknown]; Region: COG5473 1310161004776 ATP-dependent helicase HrpA; Region: DEAH_box_HrpA; TIGR01967 1310161004777 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 1310161004778 ATP binding site [chemical binding]; other site 1310161004779 putative Mg++ binding site [ion binding]; other site 1310161004780 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 1310161004781 nucleotide binding region [chemical binding]; other site 1310161004782 ATP-binding site [chemical binding]; other site 1310161004783 Helicase associated domain (HA2); Region: HA2; pfam04408 1310161004784 Oligonucleotide/oligosaccharide-binding (OB)-fold; Region: OB_NTP_bind; pfam07717 1310161004785 Domain of unknown function (DUF3418); Region: DUF3418; pfam11898 1310161004786 transcriptional regulator NrdR; Validated; Region: nrdR; PRK00464 1310161004787 ATP cone domain; Region: ATP-cone; pfam03477 1310161004788 LexA repressor; Validated; Region: PRK00215 1310161004789 LexA DNA binding domain; Region: LexA_DNA_bind; pfam01726 1310161004790 Peptidase S24 LexA-like proteins are involved in the SOS response leading to the repair of single-stranded DNA within the bacterial cell. This family includes: the lambda repressor CI/C2 family and related bacterial prophage repressor proteins; LexA (EC...; Region: S24_LexA-like; cd06529 1310161004791 Catalytic site [active] 1310161004792 Transcriptional regulators of sugar metabolism [Transcription / Carbohydrate transport and metabolism]; Region: GlpR; COG1349 1310161004793 helix_turn_helix, Deoxyribose operon repressor; Region: HTH_DEOR; smart00420 1310161004794 DeoR C terminal sensor domain; Region: DeoRC; pfam00455 1310161004795 Fructose-1-phosphate kinase and related fructose-6-phosphate kinase (PfkB) [Carbohydrate transport and metabolism]; Region: FruK; COG1105 1310161004796 ribokinase/pfkB superfamily: Kinases that accept a wide variety of substrates, including carbohydrates and aromatic small molecules, all are phosphorylated at a hydroxyl group. The superfamily includes ribokinase, fructokinase, ketohexokinase; Region: ribokinase_pfkB_like; cl00192 1310161004797 substrate binding site [chemical binding]; other site 1310161004798 ATP binding site [chemical binding]; other site 1310161004799 Phosphoenolpyruvate-protein kinase (PTS system EI component in bacteria) [Carbohydrate transport and metabolism]; Region: PtsA; COG1080 1310161004800 PEP-utilising enzyme, N-terminal; Region: PEP-utilisers_N; pfam05524 1310161004801 PEP-utilising enzyme, mobile domain; Region: PEP-utilizers; pfam00391 1310161004802 PEP-utilising enzyme, TIM barrel domain; Region: PEP-utilizers_C; pfam02896 1310161004803 Transcriptional regulators of sugar metabolism [Transcription / Carbohydrate transport and metabolism]; Region: GlpR; COG1349 1310161004804 DeoR-like helix-turn-helix domain; Region: HTH_DeoR; pfam08220 1310161004805 DeoR C terminal sensor domain; Region: DeoRC; pfam00455 1310161004806 Fructose-1-phosphate kinase and related fructose-6-phosphate kinase (PfkB) [Carbohydrate transport and metabolism]; Region: FruK; COG1105 1310161004807 1-phosphofructokinase (FruK), minor 6-phosphofructokinase (pfkB) and related sugar kinases. FruK plays an important role in the predominant pathway for fructose utilisation.This group also contains tagatose-6-phophate kinase, an enzyme of the tagatose...; Region: FruK_PfkB_like; cd01164 1310161004808 putative substrate binding site [chemical binding]; other site 1310161004809 putative ATP binding site [chemical binding]; other site 1310161004810 PTS system 2-O-a-mannosyl-D-glycerate specific transporter subunit IIABC; Provisional; Region: PRK09765 1310161004811 PTS_IIA, PTS system, fructose/mannitol specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_fru; cd00211 1310161004812 active site 1310161004813 phosphorylation site [posttranslational modification] 1310161004814 PTS_IIB_fructose: subunit IIB of enzyme II (EII) of the fructose-specific phosphoenolpyruvate:carbohydrate phosphotransferase system (PTS). In this system, EII (also referred to as FruAB) is a fructose-specific permease made up of two proteins (FruA and...; Region: PTS_IIB_fructose; cd05569 1310161004815 active site 1310161004816 P-loop; other site 1310161004817 phosphorylation site [posttranslational modification] 1310161004818 Phosphotransferase system, fructose-specific IIC component [Carbohydrate transport and metabolism]; Region: FruA; COG1299 1310161004819 Phosphotransferase System HPr (HPr) Family; Region: PTS_HPr_family; TIGR01003 1310161004820 dimerization domain swap beta strand [polypeptide binding]; other site 1310161004821 regulatory protein interface [polypeptide binding]; other site 1310161004822 active site 1310161004823 regulatory phosphorylation site [posttranslational modification]; other site 1310161004824 Transcriptional regulator, effector-binding domain/component [Transcription / Signal transduction mechanisms]; Region: COG4978 1310161004825 GTPases [General function prediction only]; Region: HflX; COG2262 1310161004826 GTP-binding GTPase N-terminal; Region: GTP-bdg_N; pfam13167 1310161004827 HflX GTPase family; Region: HflX; cd01878 1310161004828 G1 box; other site 1310161004829 GTP/Mg2+ binding site [chemical binding]; other site 1310161004830 Switch I region; other site 1310161004831 G2 box; other site 1310161004832 G3 box; other site 1310161004833 Switch II region; other site 1310161004834 G4 box; other site 1310161004835 G5 box; other site 1310161004836 diaminopimelate epimerase; Provisional; Region: dapF; PRK00450 1310161004837 Diaminopimelate epimerase; Region: DAP_epimerase; pfam01678 1310161004838 Diaminopimelate epimerase; Region: DAP_epimerase; pfam01678 1310161004839 tRNA delta(2)-isopentenylpyrophosphate transferase; Reviewed; Region: miaA; PRK00091 1310161004840 tRNA delta(2)-isopentenylpyrophosphate transferase [Translation, ribosomal structure and biogenesis]; Region: MiaA; COG0324 1310161004841 Domain of Unknown Function (DUF349); Region: DUF349; pfam03993 1310161004842 Domain of Unknown Function (DUF349); Region: DUF349; pfam03993 1310161004843 Domain of Unknown Function (DUF349); Region: DUF349; pfam03993 1310161004844 Acetyltransferases, including N-acetylases of ribosomal proteins [Translation, ribosomal structure and biogenesis]; Region: RimL; COG1670 1310161004845 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl17182 1310161004846 (dimethylallyl)adenosine tRNA methylthiotransferase; Provisional; Region: PRK14326 1310161004847 Uncharacterized protein family UPF0004; Region: UPF0004; pfam00919 1310161004848 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 1310161004849 FeS/SAM binding site; other site 1310161004850 TRAM domain; Region: TRAM; cl01282 1310161004851 lysine-arginine-ornithine-binding periplasmic protein; Region: 3A0103s03R; TIGR01096 1310161004852 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 1310161004853 substrate binding pocket [chemical binding]; other site 1310161004854 membrane-bound complex binding site; other site 1310161004855 hinge residues; other site 1310161004856 ABC-type arginine transport system, permease component [Amino acid transport and metabolism]; Region: ArtQ; COG4215 1310161004857 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1310161004858 dimer interface [polypeptide binding]; other site 1310161004859 conserved gate region; other site 1310161004860 putative PBP binding loops; other site 1310161004861 ABC-ATPase subunit interface; other site 1310161004862 ABC-type arginine transport system, permease component [Amino acid transport and metabolism]; Region: ArtQ; COG4215 1310161004863 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1310161004864 dimer interface [polypeptide binding]; other site 1310161004865 conserved gate region; other site 1310161004866 putative PBP binding loops; other site 1310161004867 ABC-ATPase subunit interface; other site 1310161004868 Uncharacterized protein conserved in bacteria [General function prediction only]; Region: OraA; COG2137 1310161004869 recombinase A; Provisional; Region: recA; PRK09354 1310161004870 RecA is a bacterial enzyme which has roles in homologous recombination, DNA repair, and the induction of the SOS response. RecA couples ATP hydrolysis to DNA strand exchange; Region: recA; cd00983 1310161004871 hexamer interface [polypeptide binding]; other site 1310161004872 Walker A motif; other site 1310161004873 ATP binding site [chemical binding]; other site 1310161004874 Walker B motif; other site 1310161004875 Protein of unknown function (DUF3046); Region: DUF3046; pfam11248 1310161004876 ECF-type riboflavin transporter, S component; Region: ECF-ribofla_trS; cl17272 1310161004877 ABC-type cobalt transport system, ATPase component [Inorganic ion transport and metabolism]; Region: CbiO; COG1122 1310161004878 First domain of the ATP-binding cassette component of cobalt transport system; Region: ABC_cobalt_CbiO_domain1; cd03225 1310161004879 Walker A/P-loop; other site 1310161004880 ATP binding site [chemical binding]; other site 1310161004881 Q-loop/lid; other site 1310161004882 ABC transporter signature motif; other site 1310161004883 Walker B; other site 1310161004884 D-loop; other site 1310161004885 H-loop/switch region; other site 1310161004886 ABC-type cobalt transport system, permease component CbiQ and related transporters [Inorganic ion transport and metabolism]; Region: CbiQ; COG0619 1310161004887 Phage shock protein A (IM30), suppresses sigma54-dependent transcription [Transcription / Signal transduction mechanisms]; Region: PspA; COG1842 1310161004888 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 1310161004889 non-specific DNA binding site [nucleotide binding]; other site 1310161004890 salt bridge; other site 1310161004891 sequence-specific DNA binding site [nucleotide binding]; other site 1310161004892 Uncharacterized protein (competence- and mitomycin-induced) [General function prediction only]; Region: CinA; COG1546 1310161004893 Phosphatidylglycerophosphate synthase [Lipid metabolism]; Region: PgsA; COG0558 1310161004894 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2350 1310161004895 integral membrane protein, TerC family; Region: R_switched_Alx; TIGR03718 1310161004896 Domain of unknown function (DUF4117); Region: DUF4117; pfam13491 1310161004897 DNA segregation ATPase FtsK/SpoIIIE and related proteins [Cell division and chromosome partitioning]; Region: FtsK; COG1674 1310161004898 FtsK/SpoIIIE family; Region: FtsK_SpoIIIE; pfam01580 1310161004899 Ftsk gamma domain; Region: Ftsk_gamma; pfam09397 1310161004900 TIGR03085 family protein; Region: TIGR03085 1310161004901 Mycothiol maleylpyruvate isomerase N-terminal domain; Region: MDMPI_N; pfam11716 1310161004902 mRNA degradation ribonucleases J1/J2 (metallo-beta-lactamase superfamily) [Translation, ribosomal structure and biogenesis; Replication, recombination and repair]; Region: COG0595 1310161004903 Metallo-beta-lactamase superfamily; Region: Lactamase_B; smart00849 1310161004904 RNA-metabolising metallo-beta-lactamase; Region: RMMBL; pfam07521 1310161004905 Dihydrodipicolinate synthase/N-acetylneuraminate lyase [Amino acid transport and metabolism / Cell envelope biogenesis, outer membrane]; Region: DapA; COG0329 1310161004906 Dihydrodipicolinate synthase (DHDPS); Region: DHDPS; cd00950 1310161004907 dimer interface [polypeptide binding]; other site 1310161004908 active site 1310161004909 catalytic residue [active] 1310161004910 FAD-dependent thymidylate synthase; Reviewed; Region: thyX; PRK00847 1310161004911 dihydrodipicolinate reductase; Provisional; Region: PRK00048 1310161004912 Dihydrodipicolinate reductase, N-terminus; Region: DapB_N; pfam01113 1310161004913 Dihydrodipicolinate reductase, C-terminus; Region: DapB_C; pfam05173 1310161004914 guanosine pentaphosphate synthetase I/polynucleotide phosphorylase; Region: pppGpp_PNP; TIGR02696 1310161004915 RNase PH-like 3'-5' exoribonucleases; Region: RNase_PH; cl03114 1310161004916 oligomer interface [polypeptide binding]; other site 1310161004917 RNA binding site [nucleotide binding]; other site 1310161004918 Polyribonucleotide nucleotidyltransferase, RNA binding domain; Region: PNPase; pfam03726 1310161004919 Polyribonucleotide nucleotidyltransferase, repeat 2; Region: RNase_PH_PNPase_2; cd11364 1310161004920 RNase E interface [polypeptide binding]; other site 1310161004921 trimer interface [polypeptide binding]; other site 1310161004922 active site 1310161004923 Polynucleotide phosphorylase (PNPase) K homology RNA-binding domain (KH). PNPase is a polyribonucleotide nucleotidyl transferase that degrades mRNA in prokaryotes and plant chloroplasts. The C-terminal region of PNPase contains domains homologous to...; Region: PNPase_KH; cd02393 1310161004924 putative nucleic acid binding region [nucleotide binding]; other site 1310161004925 G-X-X-G motif; other site 1310161004926 S1_PNPase: Polynucleotide phosphorylase (PNPase), ), S1-like RNA-binding domain. PNPase is a polyribonucleotide nucleotidyl transferase that degrades mRNA. It is a trimeric multidomain protein. The C-terminus contains the S1 domain which binds ssRNA; Region: S1_PNPase; cd04472 1310161004927 RNA binding site [nucleotide binding]; other site 1310161004928 domain interface; other site 1310161004929 Ribosomal protein S15 (prokaryotic)_S13 (eukaryotic) binds the central domain of 16S rRNA and is required for assembly of the small ribosomal subunit and for intersubunit association, thus representing a key element in the assembly of the whole ribosome; Region: Ribosomal_S15p_S13e; cd00353 1310161004930 16S/18S rRNA binding site [nucleotide binding]; other site 1310161004931 S13e-L30e interaction site [polypeptide binding]; other site 1310161004932 25S rRNA binding site [nucleotide binding]; other site 1310161004933 NH_hydro_CaPnhB: A subgroup of nucleoside hydrolases similar to Corynebacterium ammoniagenes Purine/pyrimidine nucleoside hydrolase (pnhB). Nucleoside hydrolases cleave the N-glycosidic bond in nucleosides generating ribose and the respective base. These...; Region: nuc_hydro_CaPnhB; cd02650 1310161004934 active site 1310161004935 bifunctional riboflavin kinase/FMN adenylyltransferase; Reviewed; Region: PRK05627 1310161004936 FAD synthetase, N-terminal domain of the bifunctional enzyme; Region: FAD_synthetase_N; cd02064 1310161004937 active site 1310161004938 Riboflavin kinase; Region: Flavokinase; smart00904 1310161004939 tRNA pseudouridine synthase B; Provisional; Region: truB; PRK03287 1310161004940 Pseudouridine synthase, Escherichia coli TruB like; Region: PseudoU_synth_EcTruB; cd02573 1310161004941 RNA binding site [nucleotide binding]; other site 1310161004942 active site 1310161004943 tRNA Pseudouridine synthase II, C terminal; Region: TruB_C; pfam09142 1310161004944 Phosphopantetheinyl transferase component of siderophore synthetase [Secondary metabolites biosynthesis, transport, and catabolism]; Region: EntD; COG2977 1310161004945 4'-phosphopantetheinyl transferase superfamily; Region: ACPS; pfam01648 1310161004946 Predicted phosphohydrolases [General function prediction only]; Region: Icc; COG1409 1310161004947 metallophosphatase superfamily, metallophosphatase domain; Region: MPP_superfamily; cl13995 1310161004948 active site 1310161004949 metal binding site [ion binding]; metal-binding site 1310161004950 putative phosphoesterase; Region: acc_ester; TIGR03729 1310161004951 Na+-driven multidrug efflux pump [Defense mechanisms]; Region: NorM; COG0534 1310161004952 DinF and similar proteins, a subfamily of the multidrug and toxic compound extrusion (MATE)-like proteins; Region: MATE_DinF_like; cd13136 1310161004953 Exopolyphosphatase-related proteins [General function prediction only]; Region: COG0618 1310161004954 DHH family; Region: DHH; pfam01368 1310161004955 ribosome-binding factor A; Validated; Region: rbfA; PRK00521 1310161004956 Translation initiation factor IF-2, N-terminal region; Region: IF2_N; pfam04760 1310161004957 Translation initiation factor IF-2, N-terminal region; Region: IF2_N; pfam04760 1310161004958 Translation initiation factor 2 (IF-2; GTPase) [Translation, ribosomal structure and biogenesis]; Region: InfB; COG0532 1310161004959 Initiation Factor 2 (IF2)/ eukaryotic Initiation Factor 5B (eIF5B) family; Region: IF2_eIF5B; cd01887 1310161004960 G1 box; other site 1310161004961 putative GEF interaction site [polypeptide binding]; other site 1310161004962 GTP/Mg2+ binding site [chemical binding]; other site 1310161004963 Switch I region; other site 1310161004964 G2 box; other site 1310161004965 G3 box; other site 1310161004966 Switch II region; other site 1310161004967 G4 box; other site 1310161004968 G5 box; other site 1310161004969 This family represents the domain II of bacterial Initiation Factor 2 (IF2) and its eukaryotic mitochondrial homologue mtIF2. IF2, the largest initiation factor is an essential GTP binding protein. In E. coli three natural forms of IF2 exist in the cell; Region: IF2_mtIF2_II; cd03702 1310161004970 Translation-initiation factor 2; Region: IF-2; pfam11987 1310161004971 mtIF2_IVc: this family represents the C2 subdomain of domain IV of mitochondrial translation initiation factor 2 (mtIF2) which adopts a beta-barrel fold displaying a high degree of structural similarity with domain II of the translation elongation factor...; Region: mtIF2_IVc; cd03692 1310161004972 Ylxr homologs; group of conserved hypothetical bacterial proteins of unknown function; structure revealed putative RNA binding cleft; proteins are encoded by an operon that includes other proteins involved in transcription and/or translation; Region: YlxR; cd00279 1310161004973 putative RNA binding cleft [nucleotide binding]; other site 1310161004974 transcription elongation factor NusA; Provisional; Region: nusA; PRK12327 1310161004975 NusA N-terminal domain; Region: NusA_N; pfam08529 1310161004976 S1_NusA: N-utilizing substance A protein (NusA), S1-like RNA-binding domain. S1-like RNA-binding domains are found in a wide variety of RNA-associated proteins. NusA is a transcription elongation factor containing an N-terminal catalytic domain and three...; Region: S1_NusA; cd04455 1310161004977 RNA binding site [nucleotide binding]; other site 1310161004978 homodimer interface [polypeptide binding]; other site 1310161004979 NusA-like KH domain; Region: KH_5; pfam13184 1310161004980 NusA_K homology RNA-binding domain (KH). NusA is an essential multifunctional transcription elongation factor that is universally conserved among prokaryotes and archaea. NusA anti-termination function plays an important role in the expression of...; Region: NusA_KH; cd02134 1310161004981 G-X-X-G motif; other site 1310161004982 ribosome maturation protein RimP; Reviewed; Region: PRK00092 1310161004983 Sm and related proteins; Region: Sm_like; cl00259 1310161004984 Sm and related proteins; Region: Sm_like; cl00259 1310161004985 heptamer interface [polypeptide binding]; other site 1310161004986 Sm1 motif; other site 1310161004987 hexamer interface [polypeptide binding]; other site 1310161004988 RNA binding site [nucleotide binding]; other site 1310161004989 Sm2 motif; other site 1310161004990 ABC-type oligopeptide transport system, periplasmic component [Amino acid transport and metabolism]; Region: OppA; COG4166 1310161004991 The substrate-binding domain of an ABC-type nickel/oligopeptide-like import system contains the type 2 periplasmic binding fold; Region: PBP2_NikA_DppA_OppA_like; cd00995 1310161004992 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppB; COG0601 1310161004993 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1310161004994 dimer interface [polypeptide binding]; other site 1310161004995 conserved gate region; other site 1310161004996 ABC-ATPase subunit interface; other site 1310161004997 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppC; COG1173 1310161004998 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1310161004999 dimer interface [polypeptide binding]; other site 1310161005000 conserved gate region; other site 1310161005001 putative PBP binding loops; other site 1310161005002 ABC-ATPase subunit interface; other site 1310161005003 ATPase components of various ABC-type transport systems, contain duplicated ATPase [General function prediction only]; Region: COG1123 1310161005004 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 1310161005005 Walker A/P-loop; other site 1310161005006 ATP binding site [chemical binding]; other site 1310161005007 Q-loop/lid; other site 1310161005008 ABC transporter signature motif; other site 1310161005009 Walker B; other site 1310161005010 D-loop; other site 1310161005011 H-loop/switch region; other site 1310161005012 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097 1310161005013 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 1310161005014 Walker A/P-loop; other site 1310161005015 ATP binding site [chemical binding]; other site 1310161005016 Q-loop/lid; other site 1310161005017 ABC transporter signature motif; other site 1310161005018 Walker B; other site 1310161005019 D-loop; other site 1310161005020 H-loop/switch region; other site 1310161005021 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097 1310161005022 prolyl-tRNA synthetase; Provisional; Region: PRK09194 1310161005023 Prolyl-tRNA synthetase (ProRS) class II core catalytic domain. ProRS is a homodimer. It is responsible for the attachment of proline to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for ATP-dependent...; Region: ProRS_core_prok; cd00779 1310161005024 dimer interface [polypeptide binding]; other site 1310161005025 motif 1; other site 1310161005026 active site 1310161005027 motif 2; other site 1310161005028 INS is an amino acid-editing domain inserted (INS) into the bacterial class II prolyl-tRNA synthetase (ProRS) however, this CD is not exclusively bacterial. It is also found at the N-terminus of the eukaryotic/archaea-like ProRS's of yeasts and...; Region: ProRS-INS; cd04334 1310161005029 putative deacylase active site [active] 1310161005030 Class II tRNA amino-acyl synthetase-like catalytic core domain. Class II amino acyl-tRNA synthetases (aaRS) share a common fold and generally attach an amino acid to the 3' OH of ribose of the appropriate tRNA. PheRS is an exception in that it...; Region: class_II_aaRS-like_core; cl00268 1310161005031 active site 1310161005032 motif 3; other site 1310161005033 ProRS Prolyl-anticodon binding domain, short version found predominantly in bacteria. ProRS belongs to class II aminoacyl-tRNA synthetases (aaRS). This alignment contains the anticodon binding domain, which is responsible for specificity in tRNA-binding; Region: ProRS_anticodon_short; cd00861 1310161005034 anticodon binding site; other site 1310161005035 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3022 1310161005036 Mg-chelatase subunit ChlD [Coenzyme metabolism]; Region: ChlD; COG1240 1310161005037 Magnesium chelatase: Mg-chelatase catalyses the insertion of Mg into protoporphyrin IX (Proto). In chlorophyll biosynthesis, insertion of Mg2+ into protoporphyrin IX is catalysed by magnesium chelatase in an ATP-dependent reaction. Magnesium chelatase is...; Region: vWA_Magnesium_chelatase; cd01451 1310161005038 metal ion-dependent adhesion site (MIDAS); other site 1310161005039 Mg-chelatase subunit ChlI [Coenzyme metabolism]; Region: ChlI; COG1239 1310161005040 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 1310161005041 Walker A motif; other site 1310161005042 ATP binding site [chemical binding]; other site 1310161005043 Walker B motif; other site 1310161005044 arginine finger; other site 1310161005045 Uroporphyrin-III C-methyltransferase (S-Adenosyl-L-methionine:uroporphyrinogen III methyltransferase, SUMT); Region: SUMT; cd11642 1310161005046 diphthine synthase; Region: dph5; TIGR00522 1310161005047 active site 1310161005048 SAM binding site [chemical binding]; other site 1310161005049 homodimer interface [polypeptide binding]; other site 1310161005050 Uncharacterized conserved protein [Function unknown]; Region: COG0397 1310161005051 hypothetical protein; Validated; Region: PRK00029 1310161005052 Escherichia coli PhnB and similar proteins; the E. coli phnB gene is found next to an operon involved in the cleavage of carbon-phosphorus bonds in unactivated alkylphosphonates; Region: PhnB_like; cd06588 1310161005053 dimer interface [polypeptide binding]; other site 1310161005054 Escherichia coli PhnB and similar proteins; the E. coli phnB gene is found next to an operon involved in the cleavage of carbon-phosphorus bonds in unactivated alkylphosphonates; Region: PhnB_like; cd06588 1310161005055 dimer interface [polypeptide binding]; other site 1310161005056 malate:quinone oxidoreductase; Validated; Region: PRK05257 1310161005057 malate:quinone-oxidoreductase; Region: mal_quin_oxido; TIGR01320 1310161005058 Lysophospholipase [Lipid metabolism]; Region: PldB; COG2267 1310161005059 Putative lysophospholipase; Region: Hydrolase_4; pfam12146 1310161005060 mycothione reductase; Region: mycothione_red; TIGR03452 1310161005061 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 1310161005062 Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain; Region: Pyr_redox_dim; pfam02852 1310161005063 NTF2-like N-terminal transpeptidase domain; Region: MecA_N; pfam05223 1310161005064 Cell division protein FtsI/penicillin-binding protein 2 [Cell envelope biogenesis, outer membrane]; Region: FtsI; COG0768 1310161005065 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; pfam00905 1310161005066 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 1310161005067 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1310161005068 active site 1310161005069 phosphorylation site [posttranslational modification] 1310161005070 intermolecular recognition site; other site 1310161005071 dimerization interface [polypeptide binding]; other site 1310161005072 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 1310161005073 DNA binding residues [nucleotide binding] 1310161005074 dimerization interface [polypeptide binding]; other site 1310161005075 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: COG4585 1310161005076 Histidine kinase; Region: HisKA_3; pfam07730 1310161005077 Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase; Region: HATPase_c; pfam02518 1310161005078 Mg2+ binding site [ion binding]; other site 1310161005079 G-X-G motif; other site 1310161005080 ABC-type antimicrobial peptide transport system, permease component [Defense mechanisms]; Region: SalY; COG0577 1310161005081 FtsX-like permease family; Region: FtsX; pfam02687 1310161005082 ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255 1310161005083 ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136 1310161005084 Walker A/P-loop; other site 1310161005085 ATP binding site [chemical binding]; other site 1310161005086 Q-loop/lid; other site 1310161005087 ABC transporter signature motif; other site 1310161005088 Walker B; other site 1310161005089 D-loop; other site 1310161005090 H-loop/switch region; other site 1310161005091 4-hydroxy-3-methylbut-2-en-1-yl diphosphate synthase; Reviewed; Region: ispG; PRK00366 1310161005092 4-hydroxy-3-methylbut-2-en-1-yl diphosphate synthase; Validated; Region: PRK00694 1310161005093 4-hydroxy-3-methylbut-2-en-1-yl diphosphate synthase; Validated; Region: PRK00694 1310161005094 Predicted membrane-associated Zn-dependent proteases 1 [Cell envelope biogenesis, outer membrane]; Region: COG0750 1310161005095 RseP-like Site-2 proteases (S2P), zinc metalloproteases (MEROPS family M50A), cleave transmembrane domains of substrate proteins, regulating intramembrane proteolysis (RIP) of diverse signal transduction mechanisms. In Escherichia coli, the S2P homolog...; Region: S2P-M50_PDZ_RseP-like; cd06163 1310161005096 active site 1310161005097 PDZ domain of bacterial and plant zinc metalloprotases, presumably membrane-associated or integral membrane proteases, which may be involved in signalling and regulatory mechanisms. May be responsible for substrate recognition and/or binding, as most PDZ...; Region: PDZ_metalloprotease; cd00989 1310161005098 protein binding site [polypeptide binding]; other site 1310161005099 Protein of unknown function (DUF2631); Region: DUF2631; pfam10939 1310161005100 ABC-type Na+ transport system, ATPase component [Energy production and conversion / Inorganic ion transport and metabolism]; Region: NatA; COG4555 1310161005101 ATP-binding cassette domain of the drug resistance transporter and related proteins, subfamily A; Region: ABC_DR_subfamily_A; cd03230 1310161005102 Walker A/P-loop; other site 1310161005103 ATP binding site [chemical binding]; other site 1310161005104 Q-loop/lid; other site 1310161005105 ABC transporter signature motif; other site 1310161005106 Walker B; other site 1310161005107 D-loop; other site 1310161005108 H-loop/switch region; other site 1310161005109 ribosomal RNA large subunit methyltransferase N; Provisional; Region: PRK14459 1310161005110 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 1310161005111 FeS/SAM binding site; other site 1310161005112 Uncharacterized integral membrane protein [Function unknown]; Region: COG5416 1310161005113 Cytidylyltransferase family; Region: CTP_transf_1; pfam01148 1310161005114 CDP-diglyceride synthetase [Lipid metabolism]; Region: CdsA; COG0575 1310161005115 ribosome recycling factor; Reviewed; Region: frr; PRK00083 1310161005116 Ribosome recycling factor (RRF). Ribosome recycling factor dissociates the posttermination complex, composed of the ribosome, deacylated tRNA, and mRNA, after termination of translation. Thus ribosomes are "recycled" and ready for another...; Region: RRF; cd00520 1310161005117 hinge region; other site 1310161005118 UMP kinase (UMPK)-Ec, the microbial/chloroplast uridine monophosphate kinase (uridylate kinase) enzyme that catalyzes UMP phosphorylation and plays a key role in pyrimidine nucleotide biosynthesis; regulation of this process is via feed-back control and...; Region: AAK_UMPK-PyrH-Ec; cd04254 1310161005119 putative nucleotide binding site [chemical binding]; other site 1310161005120 uridine monophosphate binding site [chemical binding]; other site 1310161005121 homohexameric interface [polypeptide binding]; other site 1310161005122 elongation factor Ts; Provisional; Region: tsf; PRK09377 1310161005123 UBA/TS-N domain; Region: UBA; pfam00627 1310161005124 Elongation factor TS; Region: EF_TS; pfam00889 1310161005125 Elongation factor TS; Region: EF_TS; pfam00889 1310161005126 Ribosomal protein S2 (RPS2), involved in formation of the translation initiation complex, where it might contact the messenger RNA and several components of the ribosome. It has been shown that in Escherichia coli RPS2 is essential for the binding of...; Region: RPS2; cd01425 1310161005127 rRNA interaction site [nucleotide binding]; other site 1310161005128 S8 interaction site; other site 1310161005129 putative laminin-1 binding site; other site 1310161005130 site-specific tyrosine recombinase XerC; Reviewed; Region: xerC; PRK00236 1310161005131 DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213 1310161005132 active site 1310161005133 DNA binding site [nucleotide binding] 1310161005134 Int/Topo IB signature motif; other site 1310161005135 Predicted Rossmann fold nucleotide-binding protein involved in DNA uptake [DNA replication, recombination, and repair / Intracellular trafficking and secretion]; Region: Smf; COG0758 1310161005136 DNA protecting protein DprA; Region: dprA; TIGR00732 1310161005137 Predicted ATPase with chaperone activity [Posttranslational modification, protein turnover, chaperones]; Region: COG0606 1310161005138 Subunit ChlI of Mg-chelatase; Region: ChlI; pfam13541 1310161005139 Magnesium chelatase, subunit ChlI; Region: Mg_chelatase; pfam01078 1310161005140 Magnesium chelatase, subunit ChlI; Region: Mg_chelatase_2; pfam13335 1310161005141 hypothetical protein; Reviewed; Region: PRK12497 1310161005142 Protein of unknown function (DUF2469); Region: DUF2469; pfam10611 1310161005143 bacterial Ribonuclease HII-like; Region: RNase_HII_bacteria_HII_like; cd07182 1310161005144 RNA/DNA hybrid binding site [nucleotide binding]; other site 1310161005145 active site 1310161005146 signal peptidase I, bacterial type; Region: sigpep_I_bact; TIGR02227 1310161005147 The S26 Type I signal peptidase (SPase; LepB; leader peptidase B; leader peptidase I; EC 3.4.21.89) family members are essential membrane-bound serine proteases that function to cleave the amino-terminal signal peptide extension from proteins that are...; Region: S26_SPase_I; cd06530 1310161005148 Catalytic site [active] 1310161005149 The S26 Type I signal peptidase (SPase; LepB; leader peptidase B; leader peptidase I; EC 3.4.21.89) family members are essential membrane-bound serine proteases that function to cleave the amino-terminal signal peptide extension from proteins that are...; Region: S26_SPase_I; cd06530 1310161005150 ABC-type Fe3+-hydroxamate transport system, periplasmic component [Inorganic ion transport and metabolism]; Region: FepB; COG0614 1310161005151 Fe3+-siderophore binding domain FhuD. These proteins have been shown to function as initial receptors in ABC transport of Fe3+-siderophores in many eubacterial species. They belong to the TroA-like superfamily of helical backbone metal receptor proteins...; Region: FhuD; cd01146 1310161005152 siderophore binding site; other site 1310161005153 50S ribosomal protein L19; Provisional; Region: rplS; PRK05338 1310161005154 Thiamine monophosphate synthase (TMP synthase)/TenI. TMP synthase catalyzes an important step in the thiamine biosynthesis pathway, the substitution of the pyrophosphate of 2-methyl-4-amino-5- hydroxymethylpyrimidine pyrophosphate by 4-methyl-5-; Region: TMP_TenI; cd00564 1310161005155 active site 1310161005156 pyrophosphate binding site [ion binding]; other site 1310161005157 thiamine phosphate binding site [chemical binding]; other site 1310161005158 glycine oxidase ThiO; Region: thiamin_ThiO; TIGR02352 1310161005159 ThiaminS ubiquitin-like sulfur carrier protein; Region: ThiS; cd00565 1310161005160 thiS-thiF/thiG interaction site; other site 1310161005161 Thiazole synthase (ThiG) is the tetrameric enzyme that is involved in the formation of the thiazole moiety of thiamin pyrophosphate, an essential ubiquitous cofactor that plays an important role in carbohydrate and amino acid metabolism. ThiG catalyzes...; Region: ThiG; cd04728 1310161005162 ThiS interaction site; other site 1310161005163 putative active site [active] 1310161005164 tetramer interface [polypeptide binding]; other site 1310161005165 thiamine biosynthesis protein ThiF; Validated; Region: PRK05600 1310161005166 ThiF_MoeB_HesA. Family of E1-like enzymes involved in molybdopterin and thiamine biosynthesis family. The common reaction mechanism catalyzed by MoeB and ThiF, like other E1 enzymes, begins with a nucleophilic attack of the C-terminal carboxylate of MoaD...; Region: ThiF_MoeB_HesA_family; cd00757 1310161005167 ATP binding site [chemical binding]; other site 1310161005168 substrate interface [chemical binding]; other site 1310161005169 Rhodanese-related sulfurtransferase [Inorganic ion transport and metabolism]; Region: PspE; COG0607 1310161005170 active site residue [active] 1310161005171 Transcriptional accessory protein [Transcription]; Region: Tex; COG2183 1310161005172 Tex-like protein N-terminal domain; Region: Tex_N; pfam09371 1310161005173 Likely ribonuclease with RNase H fold; Region: YqgFc; smart00732 1310161005174 S1_like: Ribosomal protein S1-like RNA-binding domain. Found in a wide variety of RNA-associated proteins. Originally identified in S1 ribosomal protein. This superfamily also contains the Cold Shock Domain (CSD), which is a homolog of the S1 domain; Region: S1_like; cl09927 1310161005175 RNA binding site [nucleotide binding]; other site 1310161005176 Transcriptional regulators [Transcription]; Region: PurR; COG1609 1310161005177 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 1310161005178 DNA binding site [nucleotide binding] 1310161005179 domain linker motif; other site 1310161005180 Ligand binding domain of the LacI tanscriptional regulator family belonging to the type I periplasmic-binding fold protein superfamily; Region: PBP1_LacI_sugar_binding_like; cd06267 1310161005181 dimerization interface [polypeptide binding]; other site 1310161005182 ligand binding site [chemical binding]; other site 1310161005183 Di- and tricarboxylate transporters [Inorganic ion transport and metabolism]; Region: CitT; COG0471 1310161005184 Anion permease ArsB/NhaD. These permeases have been shown to translocate sodium, arsenate, antimonite, sulfate and organic anions across biological membranes in all three kingdoms of life. A typical anion permease contains 8-13 transmembrane helices...; Region: ArsB_NhaD_permease; cd00625 1310161005185 transmembrane helices; other site 1310161005186 prokaryotic 3-carboxy-cis,cis-muconate cycloisomerase (CMLE)_like; Region: pCLME; cd01597 1310161005187 Adenylosuccinate lyase [Nucleotide transport and metabolism]; Region: PurB; COG0015 1310161005188 tetramer interface [polypeptide binding]; other site 1310161005189 active site 1310161005190 Uncharacterized membrane-associated protein [Function unknown]; Region: DedA; COG0586 1310161005191 SNARE associated Golgi protein; Region: SNARE_assoc; pfam09335 1310161005192 tRNA (guanine-N(1)-)-methyltransferase; Reviewed; Region: trmD; PRK00026 1310161005193 Protein of unknown function (DUF4232); Region: DUF4232; pfam14016 1310161005194 16S rRNA-processing protein RimM; Provisional; Region: rimM; PRK00122 1310161005195 RimM N-terminal domain; Region: RimM; pfam01782 1310161005196 PRC-barrel domain; Region: PRC; pfam05239 1310161005197 Uncharacterized conserved protein, contains double-stranded beta-helix domain [Function unknown]; Region: COG1917 1310161005198 30S ribosomal protein S16; Provisional; Region: rpsP; PRK14520 1310161005199 ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other...; Region: ANK; cd00204 1310161005200 Ankyrin repeats (3 copies); Region: Ank_2; pfam12796 1310161005201 ABC-2 family transporter protein; Region: ABC2_membrane_3; pfam12698 1310161005202 ABC-type multidrug transport system, ATPase component [Defense mechanisms]; Region: CcmA; COG1131 1310161005203 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 1310161005204 Walker A/P-loop; other site 1310161005205 ATP binding site [chemical binding]; other site 1310161005206 Q-loop/lid; other site 1310161005207 ABC transporter signature motif; other site 1310161005208 Walker B; other site 1310161005209 D-loop; other site 1310161005210 H-loop/switch region; other site 1310161005211 signal recognition particle protein; Provisional; Region: PRK10867 1310161005212 SRP54-type protein, helical bundle domain; Region: SRP54_N; smart00963 1310161005213 The signal recognition particle (SRP) mediates the transport to or across the plasma membrane in bacteria and the endoplasmic reticulum in eukaryotes. SRP recognizes N-terminal sighnal sequences of newly synthesized polypeptides at the ribosome. The...; Region: SRP; cd03115 1310161005214 P loop; other site 1310161005215 GTP binding site [chemical binding]; other site 1310161005216 Signal peptide binding domain; Region: SRP_SPB; pfam02978 1310161005217 PII uridylyl-transferase; Provisional; Region: glnD; PRK00227 1310161005218 Nucleotidyltransferase (NT) domain of Escherichia coli adenylyltransferase (GlnE), Escherichia coli uridylyl transferase (GlnD), and similar proteins; Region: NT_GlnE_GlnD_like; cd05401 1310161005219 metal binding triad; other site 1310161005220 GlnD PII-uridylyltransferase; Region: GlnD_UR_UTase; pfam08335 1310161005221 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 1310161005222 Zn2+ binding site [ion binding]; other site 1310161005223 Mg2+ binding site [ion binding]; other site 1310161005224 Nitrogen regulatory protein PII [Amino acid transport and metabolism]; Region: GlnK; COG0347 1310161005225 Nitrogen regulatory protein P-II; Region: P-II; smart00938 1310161005226 Ammonia permease [Inorganic ion transport and metabolism]; Region: AmtB; COG0004 1310161005227 Chromosome segregation ATPases [Cell division and chromosome partitioning]; Region: Smc; COG1196 1310161005228 ATP-binding cassette domain of barmotin, a member of the SMC protein family; Region: ABC_SMC_barmotin; cd03278 1310161005229 Walker A/P-loop; other site 1310161005230 ATP binding site [chemical binding]; other site 1310161005231 SMC proteins Flexible Hinge Domain; Region: SMC_hinge; pfam06470 1310161005232 ATP-binding cassette domain of barmotin, a member of the SMC protein family; Region: ABC_SMC_barmotin; cd03278 1310161005233 ABC transporter signature motif; other site 1310161005234 Walker B; other site 1310161005235 D-loop; other site 1310161005236 H-loop/switch region; other site 1310161005237 acylphosphatase; Provisional; Region: PRK14422 1310161005238 Transcriptional regulator [Transcription]; Region: LysR; COG0583 1310161005239 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 1310161005240 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 1310161005241 dimerization interface [polypeptide binding]; other site 1310161005242 hypothetical protein; Provisional; Region: PRK10621 1310161005243 Sulfite exporter TauE/SafE; Region: TauE; pfam01925 1310161005244 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4815 1310161005245 Co/Zn/Cd efflux system component [Inorganic ion transport and metabolism]; Region: CzcD; COG1230 1310161005246 N-terminal domain of Escherichia coli Fpg1/MutM and related bacterial DNA glycosylases; Region: EcFpg-like_N; cd08966 1310161005247 formamidopyrimidine/5-formyluracil/ 5-hydroxymethyluracil DNA glycosylase; Validated; Region: PRK01103 1310161005248 H2TH interface [polypeptide binding]; other site 1310161005249 DNA binding site [nucleotide binding] 1310161005250 putative catalytic residues [active] 1310161005251 turnover-facilitating residue; other site 1310161005252 intercalation triad [nucleotide binding]; other site 1310161005253 8OG recognition residue [nucleotide binding]; other site 1310161005254 putative reading head residues; other site 1310161005255 Formamidopyrimidine-DNA glycosylase H2TH domain; Region: H2TH; pfam06831 1310161005256 Zinc finger found in FPG and IleRS; Region: zf-FPG_IleRS; pfam06827 1310161005257 ribonuclease III; Reviewed; Region: rnc; PRK00102 1310161005258 RIBOc. Ribonuclease III C terminal domain. This group consists of eukaryotic, bacterial and archeal ribonuclease III (RNAse III) proteins. RNAse III is a double stranded RNA-specific endonuclease. Prokaryotic RNAse III is important in...; Region: RIBOc; cd00593 1310161005259 dimerization interface [polypeptide binding]; other site 1310161005260 active site 1310161005261 metal binding site [ion binding]; metal-binding site 1310161005262 Double-stranded RNA binding motif. Binding is not sequence specific but is highly specific for double stranded RNA. Found in a variety of proteins including dsRNA dependent protein kinase PKR, RNA helicases, Drosophila staufen protein, E. coli RNase III; Region: DSRM; cd00048 1310161005263 dsRNA binding site [nucleotide binding]; other site 1310161005264 Predicted metal-binding, possibly nucleic acid-binding protein [General function prediction only]; Region: COG1399 1310161005265 Cell division initiation protein [Cell division and chromosome partitioning]; Region: DivIVA; COG3599 1310161005266 ATP synthase B/B' CF(0); Region: ATP-synt_B; cl17192 1310161005267 ABC-type cobalt transport system, ATPase component [Inorganic ion transport and metabolism]; Region: CbiO; COG1122 1310161005268 ATP-binding cassette domain of multidrug resistance protein-like transporters; Region: ABCC_MRP_Like; cd03228 1310161005269 Walker A/P-loop; other site 1310161005270 ATP binding site [chemical binding]; other site 1310161005271 Q-loop/lid; other site 1310161005272 ABC transporter signature motif; other site 1310161005273 Walker B; other site 1310161005274 D-loop; other site 1310161005275 H-loop/switch region; other site 1310161005276 ATP-binding cassette domain of multidrug resistance protein-like transporters; Region: ABCC_MRP_Like; cd03228 1310161005277 Walker A/P-loop; other site 1310161005278 ATP binding site [chemical binding]; other site 1310161005279 ABC transporter; Region: ABC_tran; pfam00005 1310161005280 Q-loop/lid; other site 1310161005281 ABC transporter signature motif; other site 1310161005282 Walker B; other site 1310161005283 D-loop; other site 1310161005284 H-loop/switch region; other site 1310161005285 glutamate dehydrogenase; Provisional; Region: PRK09414 1310161005286 Glu/Leu/Phe/Val dehydrogenase, dimerisation domain; Region: ELFV_dehydrog_N; pfam02812 1310161005287 NAD(P) binding domain of glutamate dehydrogenase, subgroup 2; Region: NAD_bind_2_Glu_DH; cd05313 1310161005288 NAD(P) binding site [chemical binding]; other site 1310161005289 Glycerate kinase [Carbohydrate transport and metabolism]; Region: COG1929 1310161005290 Galactose-1-phosphate uridylyltransferase [Energy production and conversion]; Region: GalT; COG1085 1310161005291 HIT family: HIT (Histidine triad) proteins, named for a motif related to the sequence HxHxH/Qxx (x, a hydrophobic amino acid), are a superfamily of nucleotide hydrolases and transferases, which act on the alpha-phosphate of ribonucleotides. On the basis...; Region: HIT_like; cl00228 1310161005292 nucleotide binding site/active site [active] 1310161005293 HIT family signature motif; other site 1310161005294 catalytic residue [active] 1310161005295 Metal-dependent amidase/aminoacylase/carboxypeptidase [General function prediction only]; Region: AbgB; COG1473 1310161005296 M20 Peptidase Aminoacylase 1 subfamily; Region: M20_Acy1_like6; cd05664 1310161005297 metal binding site [ion binding]; metal-binding site 1310161005298 putative dimer interface [polypeptide binding]; other site 1310161005299 This family is most closely related to the oligosaccharide phosphorylase domain family and other unidentified sequences. Oligosaccharide phosphorylase catalyzes the breakdown of oligosaccharides into glucose-1-phosphate units. They are important...; Region: GT1_Glycogen_Phosphorylase_like; cd04299 1310161005300 putative homodimer interface [polypeptide binding]; other site 1310161005301 putative active site pocket [active] 1310161005302 alpha-glucan phosphorylases; Region: more_P_ylases; TIGR02094 1310161005303 Predicted ring-cleavage extradiol dioxygenase [General function prediction only]; Region: COG2514 1310161005304 This conserved domain belongs to a superfamily including the bleomycin resistance protein, glyoxalase I, and type I ring-cleaving dioxygenases; Region: Glo_EDI_BRP_like_12; cd07255 1310161005305 putative metal binding site [ion binding]; other site 1310161005306 This domain superfamily is found in a variety of structurally related metalloproteins, including the type I extradiol dioxygenases, glyoxalase I and a group of antibiotic resistance proteins; Region: Glo_EDI_BRP_like; cl14632 1310161005307 active site 1310161005308 pyruvate kinase; Provisional; Region: PRK06247 1310161005309 Pyruvate kinase (PK): Large allosteric enzyme that regulates glycolysis through binding of the substrate, phosphoenolpyruvate, and one or more allosteric effectors. Like other allosteric enzymes, PK has a high substrate affinity R state and a low...; Region: Pyruvate_Kinase; cl17342 1310161005310 domain interfaces; other site 1310161005311 active site 1310161005312 prolipoprotein diacylglyceryl transferase; Reviewed; Region: PRK00052 1310161005313 Indole-3-glycerol phosphate synthase [Amino acid transport and metabolism]; Region: TrpC; COG0134 1310161005314 phosphate binding site [ion binding]; other site 1310161005315 Tryptophan-associated transmembrane protein (Trp_oprn_chp); Region: Trp_oprn_chp; pfam09534 1310161005316 phosphoribosyl-AMP cyclohydrolase; Reviewed; Region: hisI; PRK00051 1310161005317 The cyclase subunit of imidazoleglycerol phosphate synthase (HisF). Imidazole glycerol phosphate synthase (IGPS) catalyzes the fifth step of histidine biosynthesis, the formation of the imidazole ring. IGPS converts N1-(5'-phosphoribulosyl)...; Region: HisF; cd04731 1310161005318 Histidine biosynthesis protein; Region: His_biosynth; pfam00977 1310161005319 substrate binding site [chemical binding]; other site 1310161005320 glutamase interaction surface [polypeptide binding]; other site 1310161005321 Inositol-monophosphatase-like domains. This family of phosphatases is dependent on bivalent metal ions such as Mg++, and many members are inhibited by Li+ (which is thought to displace a bivalent ion in the active site). Substrates include fructose-1; Region: IMPase_like; cd01637 1310161005322 Archaeal fructose-1,6-bisphosphatase and related enzymes of inositol monophosphatase family [Carbohydrate transport and metabolism]; Region: SuhB; COG0483 1310161005323 active site 1310161005324 HisA. Phosphoribosylformimino-5-aminoimidazole carboxamide ribonucleotide (ProFAR) isomerase catalyzes the fourth step in histidine biosynthesis, an isomerisation of the aminoaldose moiety of ProFAR to the aminoketose of PRFAR (N-(5'-phospho-D-1...; Region: HisA; cd04732 1310161005325 Histidine biosynthesis protein; Region: His_biosynth; pfam00977 1310161005326 catalytic residues [active] 1310161005327 imidazole glycerol phosphate synthase subunit HisH; Provisional; Region: hisH; PRK13146 1310161005328 Type 1 glutamine amidotransferase (GATase1) domain found in imidazole glycerol phosphate synthase (IGPS); Region: GATase1_IGP_Synthase; cd01748 1310161005329 putative active site [active] 1310161005330 oxyanion strand; other site 1310161005331 catalytic triad [active] 1310161005332 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1310161005333 Major Facilitator Superfamily; Region: MFS_1; pfam07690 1310161005334 putative substrate translocation pore; other site 1310161005335 Imidazoleglycerol-phosphate dehydratase; Region: IGPD; cd07914 1310161005336 putative active site pocket [active] 1310161005337 4-fold oligomerization interface [polypeptide binding]; other site 1310161005338 metal binding residues [ion binding]; metal-binding site 1310161005339 3-fold/trimer interface [polypeptide binding]; other site 1310161005340 histidinol-phosphate aminotransferase; Provisional; Region: PRK03317 1310161005341 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 1310161005342 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1310161005343 homodimer interface [polypeptide binding]; other site 1310161005344 catalytic residue [active] 1310161005345 Histidinol dehydrogenase [Amino acid transport and metabolism]; Region: HisD; COG0141 1310161005346 Histidinol dehydrogenase, HisD, E.C 1.1.1.23. Histidinol dehydrogenase catalyzes the last two steps in the L-histidine biosynthesis pathway, which is conserved in bacteria, archaea, fungi, and plants. These last two steps are (i) the NAD-dependent...; Region: Histidinol_dh; cd06572 1310161005347 NAD binding site [chemical binding]; other site 1310161005348 dimerization interface [polypeptide binding]; other site 1310161005349 product binding site; other site 1310161005350 substrate binding site [chemical binding]; other site 1310161005351 zinc binding site [ion binding]; other site 1310161005352 catalytic residues [active] 1310161005353 Putative bacterial sensory transduction regulator; Region: YbjN; pfam10722 1310161005354 Putative bacterial sensory transduction regulator; Region: YbjN; pfam10722 1310161005355 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 1310161005356 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 1310161005357 Tetracyclin repressor, C-terminal all-alpha domain; Region: TetR_C; pfam02909 1310161005358 glycogen debranching enzyme GlgX; Region: glgX_debranch; TIGR02100 1310161005359 N-terminal Early set domain associated with the catalytic domain of Glycogen debranching enzyme and bacterial isoamylase (also called glycogen 6-glucanohydrolase); Region: E_set_GDE_Isoamylase_N; cd02856 1310161005360 Alpha amylase catalytic domain found in glycogen debranching enzymes; Region: AmyAc_Glg_debranch; cd11326 1310161005361 active site 1310161005362 catalytic site [active] 1310161005363 Methyltransferase domain; Region: Methyltransf_23; pfam13489 1310161005364 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 1310161005365 S-adenosylmethionine binding site [chemical binding]; other site 1310161005366 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl17173 1310161005367 Hydroxypyruvate isomerase [Carbohydrate transport and metabolism]; Region: Hfi; COG3622 1310161005368 Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673 1310161005369 Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408 1310161005370 Oxidoreductase family, C-terminal alpha/beta domain; Region: GFO_IDH_MocA_C; pfam02894 1310161005371 Transcriptional regulators [Transcription]; Region: PurR; COG1609 1310161005372 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 1310161005373 DNA binding site [nucleotide binding] 1310161005374 domain linker motif; other site 1310161005375 Ligand binding domain of the LacI tanscriptional regulator family belonging to the type I periplasmic-binding fold protein superfamily; Region: PBP1_LacI_sugar_binding_like; cd06267 1310161005376 dimerization interface [polypeptide binding]; other site 1310161005377 ligand binding site [chemical binding]; other site 1310161005378 ATP-binding component of iron-siderophores, vitamin B12 and hemin transporters and related proteins; Region: ABC_Iron-Siderophores_B12_Hemin; cd03214 1310161005379 ABC-type cobalamin/Fe3+-siderophores transport systems, ATPase components [Inorganic ion transport and metabolism / Coenzyme metabolism]; Region: FepC; COG1120 1310161005380 Walker A/P-loop; other site 1310161005381 ATP binding site [chemical binding]; other site 1310161005382 Q-loop/lid; other site 1310161005383 ABC transporter signature motif; other site 1310161005384 Walker B; other site 1310161005385 D-loop; other site 1310161005386 H-loop/switch region; other site 1310161005387 iron-hydroxamate transporter permease subunit; Provisional; Region: PRK10577 1310161005388 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550 1310161005389 ABC-ATPase subunit interface; other site 1310161005390 dimer interface [polypeptide binding]; other site 1310161005391 putative PBP binding regions; other site 1310161005392 ABC-type Fe3+-hydroxamate transport system, periplasmic component [Inorganic ion transport and metabolism]; Region: FepB; COG0614 1310161005393 Periplasmic binding protein YvrC. These proteins are predicted to function as initial receptors in ABC transport of metal ions in eubacteria and archaea. They belong to the TroA superfamily of periplasmic metal binding proteins that share a distinct...; Region: YvrC; cd01143 1310161005394 putative binding site residues; other site 1310161005395 an uncharacterized bacterial subgroup of the DEDDh 3'-5' exonuclease domain family with similarity to the epsilon subunit of DNA polymerase III; Region: DNA_pol_III_epsilon_like; cd06130 1310161005396 active site 1310161005397 catalytic site [active] 1310161005398 substrate binding site [chemical binding]; other site 1310161005399 Maltooligosyl trehalose synthase [Carbohydrate transport and metabolism]; Region: TreY; COG3280 1310161005400 Alpha amylase catalytic domain found in maltooligosyl trehalose synthase (MTSase); Region: AmyAc_MTSase; cd11336 1310161005401 active site 1310161005402 catalytic site [active] 1310161005403 Nucleotidyltransferase (NT) domain of RelA- and SpoT-like ppGpp synthetases and hydrolases; Region: NT_Rel-Spo_like; cd05399 1310161005404 synthetase active site [active] 1310161005405 NTP binding site [chemical binding]; other site 1310161005406 metal binding site [ion binding]; metal-binding site 1310161005407 probable oxidoreductase, LLM family; Region: LLM_2I7G; TIGR03858 1310161005408 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases [Energy production and conversion]; Region: COG2141 1310161005409 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 1310161005410 RNA binding surface [nucleotide binding]; other site 1310161005411 Uncharacterized conserved protein [Function unknown]; Region: COG1739 1310161005412 Uncharacterized protein family UPF0029; Region: UPF0029; pfam01205 1310161005413 Domain of unknown function (DUF1949); Region: DUF1949; pfam09186 1310161005414 threonine dehydratase; Validated; Region: PRK08639 1310161005415 Threonine dehydratase: The first step in amino acid degradation is the removal of nitrogen. Although the nitrogen atoms of most amino acids are transferred to alpha-ketoglutarate before removal, the alpha-amino group of threonine can be directly...; Region: Thr-dehyd; cd01562 1310161005416 tetramer interface [polypeptide binding]; other site 1310161005417 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1310161005418 catalytic residue [active] 1310161005419 Second of two tandem C-terminal ACT domains of threonine dehydratase I (ThrD-I; L-threonine hydrolyase); Region: ACT_ThrD-I_2; cd04907 1310161005420 putative Ile/Val binding site [chemical binding]; other site 1310161005421 CIMS - Cobalamine-independent methonine synthase, or MetE, C-terminal domain_like. Many members have been characterized as 5-methyltetrahydropteroyltriglutamate-homocysteine methyltransferases, EC:2.1.1.14, mostly from bacteria and plants. This enzyme...; Region: CIMS_C_terminal_like; cd03311 1310161005422 substrate binding site [chemical binding]; other site 1310161005423 THF binding site; other site 1310161005424 zinc-binding site [ion binding]; other site 1310161005425 DNA polymerase III subunit alpha; Validated; Region: dnaE; PRK05673 1310161005426 Polymerase and Histidinol Phosphatase domain of alpha-subunit of bacterial polymerase III DnaE3; Region: PHP_PolIIIA_DnaE3; cd12113 1310161005427 active site 1310161005428 PHP Thumb interface [polypeptide binding]; other site 1310161005429 metal binding site [ion binding]; metal-binding site 1310161005430 DnaE_OBF: A subfamily of OB folds corresponding to the C-terminal OB-fold nucleic acid binding domain of Thermus aquaticus and Escherichia coli type C replicative DNA polymerase III alpha subunit (DnaE). The DNA polymerase holoenzyme of E. coli contains...; Region: DnaE_OBF; cd04485 1310161005431 generic binding surface II; other site 1310161005432 generic binding surface I; other site 1310161005433 Predicted permeases [General function prediction only]; Region: RarD; COG2962 1310161005434 EamA-like transporter family; Region: EamA; cl17759 1310161005435 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 1310161005436 Predicted Co/Zn/Cd cation transporters [Inorganic ion transport and metabolism]; Region: MMT1; COG0053 1310161005437 Cation efflux family; Region: Cation_efflux; pfam01545 1310161005438 oxidoreductase; Provisional; Region: PRK06128 1310161005439 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 1310161005440 NAD(P) binding site [chemical binding]; other site 1310161005441 active site 1310161005442 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4529 1310161005443 FAD-NAD(P)-binding; Region: NAD_binding_9; pfam13454 1310161005444 Diaminopimelate decarboxylase [Amino acid transport and metabolism]; Region: LysA; COG0019 1310161005445 Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzyme Y4yA; Region: PLPDE_III_Y4yA_like; cd06842 1310161005446 dimer interface [polypeptide binding]; other site 1310161005447 active site 1310161005448 pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site 1310161005449 catalytic residues [active] 1310161005450 substrate binding site [chemical binding]; other site 1310161005451 2,3-diaminopropionate biosynthesis protein SbnA; Region: PLP_SbnA_fam; TIGR03945 1310161005452 CBS_like: This subgroup includes Cystathionine beta-synthase (CBS) and Cysteine synthase. CBS is a unique heme-containing enzyme that catalyzes a pyridoxal 5'-phosphate (PLP)-dependent condensation of serine and homocysteine to give cystathionine; Region: CBS_like; cd01561 1310161005453 dimer interface [polypeptide binding]; other site 1310161005454 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1310161005455 catalytic residue [active] 1310161005456 Pseudouridylate synthases, 23S RNA-specific [Translation, ribosomal structure and biogenesis]; Region: RluA; COG0564 1310161005457 Pseudouridine synthase, RsuA/RluD family; Region: PseudoU_synth_RluCD_like; cd02869 1310161005458 active site 1310161005459 Signal peptidase (SPase) II; Region: Peptidase_A8; cl00458 1310161005460 ATPase components of ABC transporters with duplicated ATPase domains [General function prediction only]; Region: Uup; COG0488 1310161005461 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 1310161005462 Walker A/P-loop; other site 1310161005463 ATP binding site [chemical binding]; other site 1310161005464 Q-loop/lid; other site 1310161005465 ABC transporter signature motif; other site 1310161005466 Walker B; other site 1310161005467 D-loop; other site 1310161005468 H-loop/switch region; other site 1310161005469 ABC transporter; Region: ABC_tran_2; pfam12848 1310161005470 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 1310161005471 Type II (periplasmic) bacterial L-asparaginase; Region: L-asparaginase_II; cd08964 1310161005472 active site 1310161005473 homotetramer interface [polypeptide binding]; other site 1310161005474 homodimer interface [polypeptide binding]; other site 1310161005475 Transposase and inactivated derivatives, IS30 family [DNA replication, recombination, and repair]; Region: Tra8; COG2826 1310161005476 Helix-turn-helix domain; Region: HTH_38; pfam13936 1310161005477 Homeodomain-like domain; Region: HTH_32; pfam13565 1310161005478 Integrase core domain; Region: rve; pfam00665 1310161005479 DNA polymerase IV; Provisional; Region: PRK03348 1310161005480 DNA Polymerase IV/Kappa; Region: PolY_Pol_IV_kappa; cd03586 1310161005481 active site 1310161005482 DNA binding site [nucleotide binding] 1310161005483 Threonine/homoserine efflux transporter [Amino acid transport and metabolism]; Region: rhtA; COG5006 1310161005484 Helix-Turn-Helix DNA binding domain of the transcription regulators NolA and AlbR; Region: HTH_NolA-AlbR; cd04788 1310161005485 MerR HTH family regulatory protein; Region: MerR_1; pfam13411 1310161005486 DNA binding residues [nucleotide binding] 1310161005487 putative dimer interface [polypeptide binding]; other site 1310161005488 HEAT repeats; Region: HEAT_2; pfam13646 1310161005489 isoleucyl-tRNA synthetase; Reviewed; Region: ileS; PRK06039 1310161005490 catalytic core domain of isoleucyl-tRNA synthetases; Region: IleRS_core; cd00818 1310161005491 HIGH motif; other site 1310161005492 catalytic core domain of isoleucyl-tRNA synthetases; Region: IleRS_core; cd00818 1310161005493 active site 1310161005494 KMSKS motif; other site 1310161005495 Anticodon-binding domain of archaeal, bacterial, and eukaryotic cytoplasmic isoleucyl tRNA synthetases; Region: Anticodon_Ia_Ile_ABEc; cd07961 1310161005496 tRNA binding surface [nucleotide binding]; other site 1310161005497 anticodon binding site; other site 1310161005498 DivIVA protein; Region: DivIVA; pfam05103 1310161005499 DivIVA domain; Region: DivI1A_domain; TIGR03544 1310161005500 Cell division initiation protein [Cell division and chromosome partitioning]; Region: DivIVA; COG3599 1310161005501 The band 7 domain of flotillin (reggie) like proteins. This group contains proteins similar to stomatin, prohibitin, flotillin, HlfK/C and podicin. Many of these band 7 domain-containing proteins are lipid raft-associated. Individual proteins of this...; Region: Band_7; cl02525 1310161005502 Predicted integral membrane protein [Function unknown]; Region: COG0762 1310161005503 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG1799 1310161005504 Predicted enzyme with a TIM-barrel fold [General function prediction only]; Region: COG0325 1310161005505 pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site 1310161005506 catalytic residue [active] 1310161005507 Multicopper polyphenol oxidase (laccase) [Secondary metabolites biosynthesis, transport and catabolism]; Region: yfiH; COG1496 1310161005508 Multi-copper polyphenol oxidoreductase laccase; Region: Cu-oxidase_4; pfam02578 1310161005509 Cell division GTPase [Cell division and chromosome partitioning]; Region: FtsZ; COG0206 1310161005510 FtsZ is a GTPase that is similar to the eukaryotic tubulins and is essential for cell division in prokaryotes. FtsZ is capable of polymerizing in a GTP-driven process into structures similar to those formed by tubulin. FtsZ forms a ring-shaped septum at...; Region: FtsZ_type1; cd02201 1310161005511 nucleotide binding site [chemical binding]; other site 1310161005512 SulA interaction site; other site 1310161005513 Cell division septal protein [Cell envelope biogenesis, outer membrane]; Region: FtsQ; COG1589 1310161005514 POTRA domain, FtsQ-type; Region: POTRA_1; pfam08478 1310161005515 Cell division protein FtsQ; Region: FtsQ; pfam03799 1310161005516 UDP-N-acetylmuramate--L-alanine ligase; Provisional; Region: murC; PRK00421 1310161005517 Mur ligase family, catalytic domain; Region: Mur_ligase; pfam01225 1310161005518 Mur ligase middle domain; Region: Mur_ligase_M; pfam08245 1310161005519 Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875 1310161005520 undecaprenyldiphospho-muramoylpentapeptide beta-N- acetylglucosaminyltransferase; Provisional; Region: murG; PRK00726 1310161005521 MurG is an N-acetylglucosaminyltransferase, the last enzyme involved in the intracellular phase of peptidoglycan biosynthesis. It transfers N-acetyl-D-glucosamine (GlcNAc) from UDP-GlcNAc to the C4 hydroxyl of a lipid-linked N-acetylmuramoyl pentapeptide...; Region: GT1_MurG; cd03785 1310161005522 active site 1310161005523 homodimer interface [polypeptide binding]; other site 1310161005524 cell division protein FtsW; Region: ftsW; TIGR02614 1310161005525 UDP-N-acetylmuramoyl-L-alanyl-D-glutamate synthetase; Provisional; Region: murD; PRK00141 1310161005526 Mur ligase middle domain; Region: Mur_ligase_M; pfam08245 1310161005527 Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875 1310161005528 phospho-N-acetylmuramoyl-pentapeptide-transferase; Provisional; Region: mraY; PRK00108 1310161005529 Phospho-N-acetylmuramoyl-pentapeptide-transferase (mraY) is an enzyme responsible for the formation of the first lipid intermediate in the synthesis of bacterial cell wall peptidoglycan. It catalyzes the formation of...; Region: GT_MraY; cd06852 1310161005530 Mg++ binding site [ion binding]; other site 1310161005531 putative catalytic motif [active] 1310161005532 putative substrate binding site [chemical binding]; other site 1310161005533 UDP-N-acetylmuramyl pentapeptide synthase [Cell envelope biogenesis, outer membrane]; Region: MurF; COG0770 1310161005534 Mur ligase family, catalytic domain; Region: Mur_ligase; pfam01225 1310161005535 Mur ligase middle domain; Region: Mur_ligase_M; pfam08245 1310161005536 Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875 1310161005537 UDP-N-acetylmuramoylalanyl-D-glutamate--2, 6-diaminopimelate ligase; Provisional; Region: murE; PRK00139 1310161005538 Mur ligase family, catalytic domain; Region: Mur_ligase; pfam01225 1310161005539 Mur ligase middle domain; Region: Mur_ligase_M; pfam08245 1310161005540 Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875 1310161005541 Predicted S-adenosylmethionine-dependent methyltransferase involved in cell envelope biogenesis [Cell envelope biogenesis, outer membrane]; Region: COG0275 1310161005542 MraW methylase family; Region: Methyltransf_5; cl17771 1310161005543 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2001 1310161005544 MraZ protein; Region: MraZ; pfam02381 1310161005545 MraZ protein; Region: MraZ; pfam02381 1310161005546 Protein of unknown function (DUF3040); Region: DUF3040; pfam11239 1310161005547 Acetyltransferases [General function prediction only]; Region: RimI; COG0456 1310161005548 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 1310161005549 Coenzyme A binding pocket [chemical binding]; other site 1310161005550 Methylenetetrahydrofolate reductase (MTHFR). 5,10-Methylenetetrahydrofolate is reduced to 5-methyltetrahydrofolate by methylenetetrahydrofolate reductase, a cytoplasmic, NAD(P)-dependent enzyme. 5-methyltetrahydrofolate is utilized by methionine synthase...; Region: MTHFR; cd00537 1310161005551 FAD binding site [chemical binding]; other site 1310161005552 Geranylgeranyl pyrophosphate synthase [Coenzyme metabolism]; Region: IspA; COG0142 1310161005553 Trans-Isoprenyl Diphosphate Synthases, head-to-tail; Region: Trans_IPPS_HT; cd00685 1310161005554 substrate binding pocket [chemical binding]; other site 1310161005555 chain length determination region; other site 1310161005556 substrate-Mg2+ binding site; other site 1310161005557 catalytic residues [active] 1310161005558 aspartate-rich region 1; other site 1310161005559 active site lid residues [active] 1310161005560 aspartate-rich region 2; other site 1310161005561 carotene biosynthesis associated membrane protein; Region: crt_membr; TIGR03459 1310161005562 Helix-turn-helix domain; Region: HTH_17; pfam12728 1310161005563 Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220 1310161005564 Catalytic domain of Protein Kinases; Region: PKc; cd00180 1310161005565 active site 1310161005566 ATP binding site [chemical binding]; other site 1310161005567 substrate binding site [chemical binding]; other site 1310161005568 activation loop (A-loop); other site 1310161005569 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2815 1310161005570 PASTA domain; Region: PASTA; pfam03793 1310161005571 PASTA domain of bacterial serine/threonine kinase pknB-like proteins. PknB is a member of a group of related transmembrane sensor kinases present in many gram positive bacteria, which has been shown to regulate cell shape in Mycobacterium tubercolosis; Region: PASTA_pknB; cd06577 1310161005572 PASTA domain of bacterial serine/threonine kinase pknB-like proteins. PknB is a member of a group of related transmembrane sensor kinases present in many gram positive bacteria, which has been shown to regulate cell shape in Mycobacterium tubercolosis; Region: PASTA_pknB; cd06577 1310161005573 PASTA domain of bacterial serine/threonine kinase pknB-like proteins. PknB is a member of a group of related transmembrane sensor kinases present in many gram positive bacteria, which has been shown to regulate cell shape in Mycobacterium tubercolosis; Region: PASTA_pknB; cd06577 1310161005574 PASTA domain of bacterial serine/threonine kinase pknB-like proteins. PknB is a member of a group of related transmembrane sensor kinases present in many gram positive bacteria, which has been shown to regulate cell shape in Mycobacterium tubercolosis; Region: PASTA_pknB; cd06577 1310161005575 Protein of unknown function (DUF2029); Region: DUF2029; cl09812 1310161005576 Protein of unknown function (DUF2029); Region: DUF2029; pfam09594 1310161005577 Class-II DAHP synthetase family; Region: DAHP_synth_2; pfam01474 1310161005578 Protein of unknown function (DUF2029); Region: DUF2029; cl09812 1310161005579 Predicted esterase [General function prediction only]; Region: COG0627 1310161005580 Predicted membrane protein [Function unknown]; Region: COG4763 1310161005581 Acyltransferase family; Region: Acyl_transf_3; pfam01757 1310161005582 1-acyl-sn-glycerol-3-phosphate acyltransferase [Lipid metabolism]; Region: PlsC; COG0204 1310161005583 Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: AGPAT-like; Region: LPLAT_AGPAT-like; cd07989 1310161005584 putative acyl-acceptor binding pocket; other site 1310161005585 ROK family protein (putative glucokinase); Region: ROK_glcA_fam; TIGR00744 1310161005586 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cd00012 1310161005587 nucleotide binding site [chemical binding]; other site 1310161005588 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 1310161005589 This family is most closely related to the GT1 family of glycosyltransferases and named after YqgM in Bacillus licheniformis about which little is known. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to...; Region: GT1_YqgM_like; cd03801 1310161005590 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3883 1310161005591 Spectrin repeats, found in several proteins involved in cytoskeletal structure; family members include spectrin, alpha-actinin and dystrophin; the spectrin repeat forms a three helix bundle with the second helix interrupted by proline in some sequences; Region: SPEC; cl02488 1310161005592 Cell wall-associated hydrolases (invasion-associated proteins) [Cell envelope biogenesis, outer membrane]; Region: Spr; COG0791 1310161005593 NlpC/P60 family; Region: NLPC_P60; pfam00877 1310161005594 Cell wall-associated hydrolases (invasion-associated proteins) [Cell envelope biogenesis, outer membrane]; Region: Spr; COG0791 1310161005595 NlpC/P60 family; Region: NLPC_P60; pfam00877 1310161005596 Cytochrome b subunit of the bc complex [Energy production and conversion]; Region: QcrB; COG1290 1310161005597 heme bH binding site [chemical binding]; other site 1310161005598 intrachain domain interface; other site 1310161005599 heme bL binding site [chemical binding]; other site 1310161005600 interchain domain interface [polypeptide binding]; other site 1310161005601 Cytochrome b(N-terminal)/b6/petB; Region: Cytochrom_B_N_2; pfam13631 1310161005602 Qo binding site; other site 1310161005603 Rieske Fe-S protein [Energy production and conversion]; Region: QcrA; COG0723 1310161005604 Rieske domain; a [2Fe-2S] cluster binding domain commonly found in Rieske non-heme iron oxygenase (RO) systems such as naphthalene and biphenyl dioxygenases, as well as in plant/cyanobacterial chloroplast b6f and mitochondrial cytochrome bc(1) complexes; Region: Rieske; cd03467 1310161005605 iron-sulfur cluster [ion binding]; other site 1310161005606 [2Fe-2S] cluster binding site [ion binding]; other site 1310161005607 Cytochrome c, mono- and diheme variants [Energy production and conversion]; Region: CccA; COG2010 1310161005608 Cytochrome c; Region: Cytochrom_C; pfam00034 1310161005609 Cytochrome C oxidase, cbb3-type, subunit III; Region: Cytochrome_CBB3; pfam13442 1310161005610 Heme-copper oxidase subunit III. Heme-copper oxidases are transmembrane protein complexes in the respiratory chains of prokaryotes and mitochondria which couple the reduction of molecular oxygen to water to, proton pumping across the membrane. The...; Region: Heme_Cu_Oxidase_III_like; cd00386 1310161005611 Subunit I/III interface [polypeptide binding]; other site 1310161005612 Cytochrome c oxidase subunit IV; Region: Cyt_c_ox_IV; pfam12270 1310161005613 Heme/copper-type cytochrome/quinol oxidases, subunit 2 [Energy production and conversion]; Region: CyoA; COG1622 1310161005614 Cytochrome C oxidase subunit II, periplasmic domain; Region: COX2; pfam00116 1310161005615 Asparagine synthase (glutamine-hydrolyzing) [Amino acid transport and metabolism]; Region: AsnB; COG0367 1310161005616 Glutamine amidotransferases class-II (GATase) asparagine synthase_B type. Asparagine synthetase B catalyses the ATP-dependent conversion of aspartate to asparagine. This enzyme is a homodimer, with each monomer composed of a glutaminase domain and a...; Region: AsnB; cd00712 1310161005617 active site 1310161005618 dimer interface [polypeptide binding]; other site 1310161005619 The C-terminal domain of Asparagine Synthase B. This domain is always found associated n-terminal amidotransferase domain. Family members that contain this domain catalyse the conversion of aspartate to asparagine. Asparagine synthetase B catalyzes the...; Region: Asn_Synthase_B_C; cd01991 1310161005620 Ligand Binding Site [chemical binding]; other site 1310161005621 Molecular Tunnel; other site 1310161005622 Fe-S cluster assembly scaffold protein [Posttranslational modification, protein turnover, chaperones]; Region: sufA; COG0316 1310161005623 Adenosylcobinamide kinase / adenosylcobinamide phosphate guanyltransferase (CobU). CobU is bifunctional cobalbumin biosynthesis enzymes which display adenosylcobinamide kinase and adenosylcobinamide phosphate guanyltransferase activity. This enzyme is a...; Region: CobU; cd00544 1310161005624 homotrimer interface [polypeptide binding]; other site 1310161005625 Walker A motif; other site 1310161005626 GTP binding site [chemical binding]; other site 1310161005627 Walker B motif; other site 1310161005628 Phosphoribosyltransferase; Region: DBI_PRT; pfam02277 1310161005629 Nicotinate-nucleotide-dimethylbenzimidazole phosphoribosyltransferase (DMB-PRT), also called CobT; Region: DMB-PRT_CobT; cd02439 1310161005630 putative dimer interface [polypeptide binding]; other site 1310161005631 active site pocket [active] 1310161005632 putative cataytic base [active] 1310161005633 cobalamin synthase; Reviewed; Region: cobS; PRK00235 1310161005634 Short-chain alcohol dehydrogenase of unknown specificity [General function prediction only]; Region: COG4221 1310161005635 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 1310161005636 NAD(P) binding site [chemical binding]; other site 1310161005637 active site 1310161005638 Branched-chain amino acid aminotransferase; Region: DUF3665; pfam12427 1310161005639 branched-chain amino acid aminotransferase; Provisional; Region: PRK13357 1310161005640 BCAT_beta_family: Branched-chain aminotransferase catalyses the transamination of the branched-chain amino acids leusine, isoleucine and valine to their respective alpha-keto acids, alpha-ketoisocaproate, alpha-keto-beta-methylvalerate and...; Region: BCAT_beta_family; cd01557 1310161005641 homodimer interface [polypeptide binding]; other site 1310161005642 substrate-cofactor binding pocket; other site 1310161005643 catalytic residue [active] 1310161005644 Cytosol aminopeptidase family, N-terminal and catalytic domains. Family M17 contains zinc- and manganese-dependent exopeptidases ( EC 3.4.11.1), including leucine aminopeptidase. They catalyze removal of amino acids from the N-terminus of a protein and...; Region: Peptidase_M17; cd00433 1310161005645 multifunctional aminopeptidase A; Provisional; Region: PRK00913 1310161005646 interface (dimer of trimers) [polypeptide binding]; other site 1310161005647 Substrate-binding/catalytic site; other site 1310161005648 Zn-binding sites [ion binding]; other site 1310161005649 pyruvate dehydrogenase dihydrolipoyltransacetylase; Validated; Region: aceF; PRK11854 1310161005650 Lipoyl domain of the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases. 2-oxo acid dehydrogenase multienzyme complexes, like pyruvate dehydrogenase (PDH), 2-oxoglutarate dehydrogenase (OGDH) and branched-chain 2-oxo acid...; Region: lipoyl_domain; cd06849 1310161005651 E3 interaction surface; other site 1310161005652 lipoyl attachment site [posttranslational modification]; other site 1310161005653 Lipoyl domain of the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases. 2-oxo acid dehydrogenase multienzyme complexes, like pyruvate dehydrogenase (PDH), 2-oxoglutarate dehydrogenase (OGDH) and branched-chain 2-oxo acid...; Region: lipoyl_domain; cd06849 1310161005654 E3 interaction surface; other site 1310161005655 lipoyl attachment site [posttranslational modification]; other site 1310161005656 Lipoyl domain of the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases. 2-oxo acid dehydrogenase multienzyme complexes, like pyruvate dehydrogenase (PDH), 2-oxoglutarate dehydrogenase (OGDH) and branched-chain 2-oxo acid...; Region: lipoyl_domain; cd06849 1310161005657 E3 interaction surface; other site 1310161005658 lipoyl attachment site [posttranslational modification]; other site 1310161005659 e3 binding domain; Region: E3_binding; pfam02817 1310161005660 2-oxoacid dehydrogenases acyltransferase (catalytic domain); Region: 2-oxoacid_dh; pfam00198 1310161005661 lipoate-protein ligase B; Provisional; Region: PRK14345 1310161005662 lipoyl synthase; Provisional; Region: PRK05481 1310161005663 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 1310161005664 FeS/SAM binding site; other site 1310161005665 Domain of unknown function (DUF4191); Region: DUF4191; pfam13829 1310161005666 Predicted permease [General function prediction only]; Region: COG2985 1310161005667 Predicted Permease Membrane Region; Region: Asp-Al_Ex; pfam06826 1310161005668 TrkA-C domain; Region: TrkA_C; pfam02080 1310161005669 AspT/YidE/YbjL antiporter duplication domain; Region: YidE_YbjL_dupl; TIGR01625 1310161005670 Transposase and inactivated derivatives, IS30 family [DNA replication, recombination, and repair]; Region: Tra8; COG2826 1310161005671 Helix-turn-helix domain; Region: HTH_38; pfam13936 1310161005672 Homeodomain-like domain; Region: HTH_32; pfam13565 1310161005673 Integrase core domain; Region: rve; pfam00665 1310161005674 RDD family; Region: RDD; pfam06271 1310161005675 glutamine synthetase, type I; Region: GlnA; TIGR00653 1310161005676 Glutamine synthetase, beta-Grasp domain; Region: Gln-synt_N; pfam03951 1310161005677 Glutamine synthetase, catalytic domain; Region: Gln-synt_C; pfam00120 1310161005678 Uncharacterized conserved protein, contains double-stranded beta-helix domain [Function unknown]; Region: COG1917 1310161005679 Members of the Nudix hydrolase superfamily catalyze the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+, for their activity and contain a highly...; Region: Nudix_Hydrolase_17; cd04676 1310161005680 nudix motif; other site 1310161005681 luciferase-type oxidoreductase, BA3436 family; Region: lucif_BA3436; TIGR03571 1310161005682 Flavin-utilizing monoxygenases; Region: Flavin_utilizing_monoxygenases; cl07892 1310161005683 Threonine synthase [Amino acid transport and metabolism]; Region: ThrC; COG0498 1310161005684 Threonine synthase catalyzes the final step of threonine biosynthesis. The conversion of O-phosphohomoserine into threonine and inorganic phosphate is pyridoxal 5'-phosphate dependent. The Thr-synth_1 CD includes members from higher plants; Region: Thr-synth_2; cd01560 1310161005685 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1310161005686 catalytic residue [active] 1310161005687 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1310161005688 Major Facilitator Superfamily; Region: MFS_1; pfam07690 1310161005689 putative substrate translocation pore; other site 1310161005693 Heme oxygenase catalyzes the rate limiting step in the degradation of heme to bilirubin, it is essential for recycling of iron from heme. Heme is used as a substrate and cofactor for its own degradation to biliverdin, iron, and carbon monoxide. This...; Region: HemeO; cd00232 1310161005694 heme binding pocket [chemical binding]; other site 1310161005695 heme ligand [chemical binding]; other site 1310161005696 bifunctional glutamine-synthetase adenylyltransferase/deadenyltransferase; Provisional; Region: PRK14109 1310161005697 Nucleotidyltransferase (NT) domain of Escherichia coli adenylyltransferase (GlnE), Escherichia coli uridylyl transferase (GlnD), and similar proteins; Region: NT_GlnE_GlnD_like; cd05401 1310161005698 metal binding triad; other site 1310161005699 GlnD PII-uridylyltransferase; Region: GlnD_UR_UTase; pfam08335 1310161005700 Nucleotidyltransferase (NT) domain of Escherichia coli adenylyltransferase (GlnE), Escherichia coli uridylyl transferase (GlnD), and similar proteins; Region: NT_GlnE_GlnD_like; cd05401 1310161005701 metal binding triad; other site 1310161005702 GlnD PII-uridylyltransferase; Region: GlnD_UR_UTase; pfam08335 1310161005703 Glutamine synthetase [Amino acid transport and metabolism]; Region: GlnA; COG0174 1310161005704 Glutamine synthetase, beta-Grasp domain; Region: Gln-synt_N; pfam03951 1310161005705 Glutamine synthetase, catalytic domain; Region: Gln-synt_C; pfam00120 1310161005706 CYTH-like (also known as triphosphate tunnel metalloenzyme (TTM)-like) Phosphatases; Region: CYTH-like_Pase; cd07374 1310161005707 putative active site; other site 1310161005708 putative metal binding residues [ion binding]; other site 1310161005709 signature motif; other site 1310161005710 putative triphosphate binding site [ion binding]; other site 1310161005711 CHAD domain; Region: CHAD; pfam05235 1310161005712 CHAD domain; Region: CHAD; pfam05235 1310161005713 Galactokinase [Carbohydrate transport and metabolism]; Region: GalK; COG0153 1310161005714 Galactokinase galactose-binding signature; Region: GalKase_gal_bdg; pfam10509 1310161005715 GHMP kinases N terminal domain; Region: GHMP_kinases_N; pfam00288 1310161005716 bifunctional RNase H/acid phosphatase; Provisional; Region: PRK07238 1310161005717 RNAse HI family that includes Archaeal RNase HI; Region: RNase_HI_archaeal_like; cd09279 1310161005718 RNA/DNA hybrid binding site [nucleotide binding]; other site 1310161005719 active site 1310161005720 Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067 1310161005721 catalytic core [active] 1310161005722 Zn-ribbon protein, possibly nucleic acid-binding [General function prediction only]; Region: COG1579 1310161005723 Putative zinc ribbon domain; Region: DUF164; pfam02591 1310161005724 Uncharacterized conserved protein [Function unknown]; Region: COG0327 1310161005725 NIF3 (NGG1p interacting factor 3); Region: NIF3; pfam01784 1310161005726 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3323 1310161005727 NIF3 (NGG1p interacting factor 3); Region: NIF3; pfam01784 1310161005728 Uncharacterized conserved protein [Function unknown]; Region: COG0327 1310161005729 Predicted phosphatases [General function prediction only]; Region: Gph; COG0546 1310161005730 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 1310161005731 motif II; other site 1310161005732 Protein-tyrosine-phosphatase [Signal transduction mechanisms]; Region: Wzb; COG0394 1310161005733 Low molecular weight phosphatase family; Region: LMWPc; cd00115 1310161005734 active site 1310161005735 SURF1 superfamily. Surf1/Shy1 has been implicated in the posttranslational steps of the biogenesis of the mitochondrially-encoded Cox1 subunit of cytochrome c oxidase (complex IV). Cytochrome c oxidase (complex IV), the terminal electron-transferring...; Region: SURF1; cd06662 1310161005736 Transposase DDE domain; Region: DDE_Tnp_1; pfam01609 1310161005737 Transposase DDE domain; Region: DDE_Tnp_1_2; pfam13586 1310161005739 Protein of unknown function (DUF3052); Region: DUF3052; pfam11253 1310161005740 pyruvate dehydrogenase subunit E1; Reviewed; Region: aceE; PRK09405 1310161005741 Thiamine pyrophosphate (TPP) family, E1 of E. coli PDC-like subfamily, TPP-binding module; composed of proteins similar to the E1 component of the Escherichia coli pyruvate dehydrogenase multienzyme complex (PDC). PDC catalyzes the oxidative...; Region: TPP_E1_EcPDC_like; cd02017 1310161005742 dimer interface [polypeptide binding]; other site 1310161005743 TPP-binding site [chemical binding]; other site 1310161005744 ABC-type uncharacterized transport system, ATPase component [General function prediction only]; Region: PhnK; COG1101 1310161005745 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 1310161005746 Walker A/P-loop; other site 1310161005747 ATP binding site [chemical binding]; other site 1310161005748 Q-loop/lid; other site 1310161005749 ABC transporter signature motif; other site 1310161005750 Walker B; other site 1310161005751 D-loop; other site 1310161005752 H-loop/switch region; other site 1310161005753 Transmembrane subunit (TM) of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which are involved in the uptake of branched-chain amino acids (AAs), as well as TMs of transporters involved in the uptake of...; Region: TM_PBP1_branched-chain-AA_like; cd06574 1310161005754 Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653 1310161005755 TM-ABC transporter signature motif; other site 1310161005756 Type I periplasmic ligand-binding domain of uncharacterized ABC-type transport systems that are predicted to be involved in the uptake of amino acids, peptides, or inorganic ions; Region: PBP1_ABC_uncharacterized_transporter; cd06325 1310161005757 zinc binding site [ion binding]; other site 1310161005758 putative ligand binding site [chemical binding]; other site 1310161005759 Domain of unknown function (DUF1707); Region: DUF1707; pfam08044 1310161005760 Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596 1310161005761 Serine hydrolase; Region: Ser_hydrolase; cl17834 1310161005762 acyl carrier protein; Provisional; Region: acpP; PRK00982 1310161005763 Predicted sugar phosphatases of the HAD superfamily [Carbohydrate transport and metabolism]; Region: NagD; COG0647 1310161005764 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 1310161005765 active site 1310161005766 motif I; other site 1310161005767 motif II; other site 1310161005768 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 1310161005769 Uncharacterized conserved protein [Function unknown]; Region: COG4850 1310161005770 Uncharacterized conserved protein (DUF2183); Region: DUF2183; pfam09949 1310161005771 Beta-lactamase; Region: Beta-lactamase; pfam00144 1310161005772 Beta-lactamase class C and other penicillin binding proteins [Defense mechanisms]; Region: AmpC; COG1680 1310161005773 Domain of unknown function (DUF4274); Region: DUF4274; pfam14096 1310161005774 Phosphodiesterase/alkaline phosphatase D [Inorganic ion transport and metabolism]; Region: PhoD; COG3540 1310161005775 Bacillus subtilis PhoD and related proteins, metallophosphatase domain; Region: MPP_PhoD; cd07389 1310161005776 putative active site [active] 1310161005777 putative metal binding site [ion binding]; other site 1310161005778 metallophosphatase superfamily, metallophosphatase domain; Region: MPP_superfamily; cl13995 1310161005779 Glucoamylase and related glycosyl hydrolases [Carbohydrate transport and metabolism]; Region: SGA1; COG3387 1310161005780 Glycosyl hydrolases family 15; Region: Glyco_hydro_15; pfam00723 1310161005781 DNA primase; Validated; Region: dnaG; PRK05667 1310161005782 CHC2 zinc finger; Region: zf-CHC2; pfam01807 1310161005783 DNA primase catalytic core, N-terminal domain; Region: Toprim_N; pfam08275 1310161005784 TOPRIM_DnaG_primases: The topoisomerase-primase (TORPIM) nucleotidyl transferase/hydrolase domain found in the active site regions of proteins similar to Escherichia coli DnaG. Primases synthesize RNA primers for the initiation of DNA replication. DnaG...; Region: TOPRIM_DnaG_primases; cd03364 1310161005785 active site 1310161005786 metal binding site [ion binding]; metal-binding site 1310161005787 interdomain interaction site; other site 1310161005788 DnaB-helicase binding domain of primase; Region: DnaB_bind; pfam10410 1310161005789 DNA primase DnaG DnaB-binding; Region: DnaG_DnaB_bind; smart00766 1310161005790 RNase_Sa. Ribonucleases first isolated from Streptomyces aureofaciens. In general, ribonucleases cleave phosphodiester bonds in RNA and are essential for both non-specific RNA degradation and for numerous forms of RNA processing. RNAse Sa is a guanylate...; Region: RNase_Sa; cd00607 1310161005791 active site 1310161005792 barstar interaction site; other site 1310161005793 glucosamine--fructose-6-phosphate aminotransferase; Reviewed; Region: PRK00331 1310161005794 Glutamine amidotransferases class-II (Gn-AT)_GFAT-type. This domain is found at the N-terminus of glucosamine-6P synthase (GlmS, or GFAT in humans). The glutaminase domain catalyzes amide nitrogen transfer from glutamine to the appropriate substrate. In...; Region: GFAT; cd00714 1310161005795 glutaminase active site [active] 1310161005796 SIS (Sugar ISomerase) domain repeat 1 found in Glucosamine 6-phosphate synthase (GlmS) and Glucosamine-6-phosphate deaminase (GlmD). The SIS domain is found in many phosphosugar isomerases and phosphosugar binding proteins. GlmS contains a N-terminal...; Region: SIS_GlmS_GlmD_1; cd05008 1310161005797 dimer interface [polypeptide binding]; other site 1310161005798 active site 1310161005799 SIS (Sugar ISomerase) domain repeat 2 found in Glucosamine 6-phosphate synthase (GlmS) and Glucosamine-6-phosphate deaminase (GlmD). The SIS domain is found in many phosphosugar isomerases and phosphosugar binding proteins. GlmS contains a N-terminal...; Region: SIS_GlmS_GlmD_2; cd05009 1310161005800 dimer interface [polypeptide binding]; other site 1310161005801 active site 1310161005802 deoxyguanosinetriphosphate triphosphohydrolase-like protein; Provisional; Region: PRK03007 1310161005803 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 1310161005804 Zn2+ binding site [ion binding]; other site 1310161005805 Mg2+ binding site [ion binding]; other site 1310161005806 Phosphohydrolase-associated domain; Region: HD_assoc; pfam13286 1310161005807 Uncharacterized conserved protein [Function unknown]; Region: COG1434 1310161005808 YdcF-like. YdcF-like is a large family of mainly bacterial proteins, with a few members found in fungi, plants, and archaea. Escherichia coli YdcF has been shown to bind S-adenosyl-L-methionine (AdoMet), but a biochemical function has not been...; Region: YdcF-like; cd06259 1310161005809 putative active site [active] 1310161005810 Repair protein; Region: Repair_PSII; pfam04536 1310161005811 glycyl-tRNA synthetase; Provisional; Region: PRK04173 1310161005812 Class II tRNA amino-acyl synthetase-like catalytic core domain. Class II amino acyl-tRNA synthetases (aaRS) share a common fold and generally attach an amino acid to the 3' OH of ribose of the appropriate tRNA. PheRS is an exception in that it...; Region: class_II_aaRS-like_core; cl00268 1310161005813 motif 1; other site 1310161005814 Glycyl-tRNA synthetase (GlyRS)-like class II core catalytic domain. GlyRS functions as a homodimer in eukaryotes, archaea and some bacteria and as a heterotetramer in the remainder of prokaryotes. It is responsible for the attachment of glycine to the 3...; Region: GlyRS-like_core; cd00774 1310161005815 active site 1310161005816 motif 2; other site 1310161005817 motif 3; other site 1310161005818 GlyRS Glycyl-anticodon binding domain. GlyRS belongs to class II aminoacyl-tRNA synthetases (aaRS). This alignment contains the anticodon binding domain, which is responsible for specificity in tRNA-binding, so that the activated amino acid is...; Region: GlyRS_anticodon; cd00858 1310161005819 anticodon binding site; other site 1310161005820 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 1310161005821 dimerization interface [polypeptide binding]; other site 1310161005822 putative DNA binding site [nucleotide binding]; other site 1310161005823 putative Zn2+ binding site [ion binding]; other site 1310161005824 Ferric uptake regulator(Fur) and related metalloregulatory proteins; typically iron-dependent, DNA-binding repressors and activators; Region: Fur_like; cd07153 1310161005825 metal binding site 2 [ion binding]; metal-binding site 1310161005826 putative DNA binding helix; other site 1310161005827 metal binding site 1 [ion binding]; metal-binding site 1310161005828 dimer interface [polypeptide binding]; other site 1310161005829 structural Zn2+ binding site [ion binding]; other site 1310161005830 Domain of unknown function (DUF222); Region: DUF222; pfam02720 1310161005831 HNH nucleases; HNH endonuclease signature which is found in viral, prokaryotic, and eukaryotic proteins. The alignment includes members of the large group of homing endonucleases, yeast intron 1 protein, MutS, as well as bacterial colicins, pyocins, and...; Region: HNHc; cd00085 1310161005832 active site 1310161005833 Ferritin-CCC1, N-terminal ferritin-like diiron-binding domain; Region: Ferritin_CCC1_N; cd01044 1310161005834 diiron binding motif [ion binding]; other site 1310161005835 Nodulin-21 and CCC1-related protein family; Region: Nodulin-21_like_2; cd02433 1310161005836 Undecaprenyl pyrophosphate synthase [Lipid metabolism]; Region: UppS; COG0020 1310161005837 Cis (Z)-Isoprenyl Diphosphate Synthases (cis-IPPS); homodimers which catalyze the successive 1'-4 condensation of the isopentenyl diphosphate (IPP) molecule to trans,trans-farnesyl diphosphate (FPP) or to cis,trans-FPP to form long-chain polyprenyl...; Region: CIS_IPPS; cd00475 1310161005838 catalytic residue [active] 1310161005839 putative FPP diphosphate binding site; other site 1310161005840 putative FPP binding hydrophobic cleft; other site 1310161005841 dimer interface [polypeptide binding]; other site 1310161005842 putative IPP diphosphate binding site; other site 1310161005843 Recombination protein O N terminal; Region: RecO_N; pfam11967 1310161005844 DNA repair protein RecO; Reviewed; Region: recO; PRK00085 1310161005845 Recombination protein O C terminal; Region: RecO_C; pfam02565 1310161005846 GTPase Era; Reviewed; Region: era; PRK00089 1310161005847 E. coli Ras-like protein (Era) is a multifunctional GTPase; Region: Era; cd04163 1310161005848 G1 box; other site 1310161005849 GTP/Mg2+ binding site [chemical binding]; other site 1310161005850 Switch I region; other site 1310161005851 G2 box; other site 1310161005852 Switch II region; other site 1310161005853 G3 box; other site 1310161005854 G4 box; other site 1310161005855 G5 box; other site 1310161005856 KH domain; Region: KH_2; pfam07650 1310161005857 Hemolysins and related proteins containing CBS domains [General function prediction only]; Region: TlyC; COG1253 1310161005858 Domain of unknown function DUF21; Region: DUF21; pfam01595 1310161005859 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains associated with the CorC_HlyC domain. CorC_HlyC is a transporter associated domain. This small domain is found in Na+/H+ antiporters, in proteins involved in...; Region: CBS_pair_CorC_HlyC_assoc; cd04590 1310161005860 Transporter associated domain; Region: CorC_HlyC; smart01091 1310161005861 metal-binding heat shock protein; Provisional; Region: PRK00016 1310161005862 Phosphate starvation-inducible protein PhoH, predicted ATPase [Signal transduction mechanisms]; Region: PhoH; COG1702 1310161005863 PhoH-like protein; Region: PhoH; pfam02562 1310161005864 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG1385 1310161005865 RNA methyltransferase, RsmE family; Region: TIGR00046 1310161005866 chaperone protein DnaJ; Provisional; Region: PRK14278 1310161005867 DnaJ domain or J-domain. DnaJ/Hsp40 (heat shock protein 40) proteins are highly conserved and play crucial roles in protein translation, folding, unfolding, translocation, and degradation. They act primarily by stimulating the ATPase activity of Hsp70s; Region: DnaJ; cd06257 1310161005868 HSP70 interaction site [polypeptide binding]; other site 1310161005869 Zinc finger domain of DnaJ and HSP40; Region: DnaJ_zf; cd10719 1310161005870 Zn binding sites [ion binding]; other site 1310161005871 C-terminal substrate binding domain of DnaJ and HSP40; Region: DnaJ_C; cd10747 1310161005872 dimer interface [polypeptide binding]; other site 1310161005873 heat-inducible transcription repressor; Provisional; Region: hrcA; PRK00082 1310161005874 coproporphyrinogen III oxidase; Validated; Region: PRK05628 1310161005875 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 1310161005876 FeS/SAM binding site; other site 1310161005877 HemN C-terminal domain; Region: HemN_C; pfam06969 1310161005878 Long-chain acyl-CoA synthetases (AMP-forming) [Lipid metabolism]; Region: FAA1; COG1022 1310161005879 Long-chain fatty acid CoA synthetases and Bubblegum-like very long-chain fatty acid CoA synthetases; Region: VL_LC_FACS_like; cd05907 1310161005880 acyl-activating enzyme (AAE) consensus motif; other site 1310161005881 putative AMP binding site [chemical binding]; other site 1310161005882 putative active site [active] 1310161005883 putative CoA binding site [chemical binding]; other site 1310161005884 4-alpha-glucanotransferase; Provisional; Region: malQ; PRK11052 1310161005885 4-alpha-glucanotransferase [Carbohydrate transport and metabolism]; Region: MalQ; COG1640 1310161005886 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 1310161005887 ABC-type transport system involved in Fe-S cluster assembly, permease and ATPase components [Posttranslational modification, protein turnover, chaperones]; Region: ATM1; COG5265 1310161005888 ATP-binding cassette domain of the bacterial lipid flippase and related proteins, subfamily C; Region: ABCC_MsbA; cd03251 1310161005889 Walker A/P-loop; other site 1310161005890 ATP binding site [chemical binding]; other site 1310161005891 Q-loop/lid; other site 1310161005892 ABC transporter signature motif; other site 1310161005893 Walker B; other site 1310161005894 D-loop; other site 1310161005895 H-loop/switch region; other site 1310161005896 Zn-dependent oligopeptidases [Amino acid transport and metabolism]; Region: Dcp; COG0339 1310161005897 Peptidase family M3 dipeptidyl carboxypeptidase (DCP); Region: M3A_DCP; cd06456 1310161005898 active site 1310161005899 Zn binding site [ion binding]; other site 1310161005900 Carboxylesterase type B [Lipid metabolism]; Region: PnbA; COG2272 1310161005901 Esterases and lipases (includes fungal lipases, cholinesterases, etc.) These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cd00312 1310161005902 substrate binding pocket [chemical binding]; other site 1310161005903 catalytic triad [active] 1310161005904 trehalose synthase; Region: treS_nterm; TIGR02456 1310161005905 Alpha amylase catalytic domain found in Trehalose synthetase; Region: AmyAc_TreS; cd11334 1310161005906 active site 1310161005907 catalytic site [active] 1310161005908 Uncharacterized protein, probably involved in trehalose biosynthesis [Carbohydrate transport and metabolism]; Region: Ble; COG3281 1310161005909 Isopentenyldiphosphate isomerase [Lipid metabolism]; Region: Idi; COG1443 1310161005910 Isopentenyl diphosphate (IPP) isomerase, a member of the Nudix hydrolase superfamily, is a key enzyme in the isoprenoid biosynthetic pathway. Isoprenoids comprise a large family of natural products including sterols, carotenoids, dolichols and prenylated...; Region: IPP_Isomerase; cd02885 1310161005911 active site 1310161005912 metal binding site [ion binding]; metal-binding site 1310161005913 nudix motif; other site 1310161005914 Protein of unknown function (DUF3558); Region: DUF3558; pfam12079 1310161005915 Bifunctional PLP-dependent enzyme with beta-cystathionase and maltose regulon repressor activities [Amino acid transport and metabolism]; Region: MalY; COG1168 1310161005916 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 1310161005917 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1310161005918 homodimer interface [polypeptide binding]; other site 1310161005919 catalytic residue [active] 1310161005920 Branched-chain amino acid transport protein; Region: Branch_AA_trans; pfam05525 1310161005921 luciferase family oxidoreductase, group 1; Region: oxido_grp_1; TIGR03558 1310161005922 Flavin-utilizing monoxygenases; Region: Flavin_utilizing_monoxygenases; cl07892 1310161005923 choline/carnitine/betaine transport; Region: bcct; TIGR00842 1310161005924 Predicted permeases [General function prediction only]; Region: COG0679 1310161005925 FAD/FMN-containing dehydrogenases [Energy production and conversion]; Region: GlcD; COG0277 1310161005926 FAD binding domain; Region: FAD_binding_4; pfam01565 1310161005927 Fe-S oxidoreductase [Energy production and conversion]; Region: GlpC; COG0247 1310161005928 Transcriptional regulators [Transcription]; Region: GntR; COG1802 1310161005929 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 1310161005930 DNA-binding site [nucleotide binding]; DNA binding site 1310161005931 FCD domain; Region: FCD; pfam07729 1310161005932 DctM-like transporters; Region: DctM; pfam06808 1310161005933 TRAP-type C4-dicarboxylate transport system, large permease component [Carbohydrate transport and metabolism]; Region: DctQ; COG1593 1310161005934 ABC-type dipeptide transport system, periplasmic component [Amino acid transport and metabolism]; Region: DdpA; COG0747 1310161005935 The substrate-binding component of an uncharacterized ABC-type nickel/dipeptide/oligopeptide-like import system contains the type 2 periplasmic binding fold; Region: PBP2_NikA_DppA_OppA_like_6; cd08494 1310161005936 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppB; COG0601 1310161005937 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cl00427 1310161005938 nickel ABC transporter, permease subunit NikC; Region: nickel_nikC; TIGR02790 1310161005939 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1310161005940 dimer interface [polypeptide binding]; other site 1310161005941 conserved gate region; other site 1310161005942 putative PBP binding loops; other site 1310161005943 ABC-ATPase subunit interface; other site 1310161005944 ATPase components of various ABC-type transport systems, contain duplicated ATPase [General function prediction only]; Region: COG1123 1310161005945 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 1310161005946 Walker A/P-loop; other site 1310161005947 ATP binding site [chemical binding]; other site 1310161005948 Q-loop/lid; other site 1310161005949 ABC transporter signature motif; other site 1310161005950 Walker B; other site 1310161005951 D-loop; other site 1310161005952 H-loop/switch region; other site 1310161005953 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097 1310161005954 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 1310161005955 Walker A/P-loop; other site 1310161005956 ATP binding site [chemical binding]; other site 1310161005957 Q-loop/lid; other site 1310161005958 ABC transporter signature motif; other site 1310161005959 Walker B; other site 1310161005960 D-loop; other site 1310161005961 H-loop/switch region; other site 1310161005962 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097 1310161005963 2'-5' RNA ligase [Translation, ribosomal structure and biogenesis]; Region: LigT; COG1514 1310161005964 LigT like Phosphoesterase; Region: LigT_PEase; pfam02834 1310161005965 Sugar kinases, ribokinase family [Carbohydrate transport and metabolism]; Region: RbsK; COG0524 1310161005966 Ribokinase catalyses the phosphorylation of ribose to ribose-5-phosphate using ATP. This reaction is the first step in the ribose metabolism. It traps ribose within the cell after uptake and also prepares the sugar for use in the synthesis of nucleotides...; Region: ribokinase; cd01174 1310161005967 substrate binding site [chemical binding]; other site 1310161005968 dimer interface [polypeptide binding]; other site 1310161005969 ATP binding site [chemical binding]; other site 1310161005970 bile acid transporter; Region: bass; TIGR00841 1310161005971 Sodium Bile acid symporter family; Region: SBF; pfam01758 1310161005972 D-hexose-6-phosphate epimerase-like; Region: D-hex-6-P-epi_like; cd09020 1310161005973 active site 1310161005974 phosphate binding residues; other site 1310161005975 catalytic residues [active] 1310161005976 malate synthase G; Provisional; Region: PRK02999 1310161005977 active site 1310161005978 isocitrate lyase; Provisional; Region: PRK15063 1310161005979 Members of the ICL/PEPM enzyme family catalyze either P-C or C-C bond formation/cleavage. Known members are phosphoenolpyruvate mutase (PEPM), phosphonopyruvate hydrolase (PPH), carboxyPEP mutase (CPEP mutase), oxaloacetate hydrolase (OAH), isocitrate...; Region: ICL_PEPM; cd00377 1310161005980 tetramer interface [polypeptide binding]; other site 1310161005981 active site 1310161005982 Mg2+/Mn2+ binding site [ion binding]; other site 1310161005983 Aquifex aeolicus AQ1575 and related proteins, metallophosphatase domain; Region: MPP_AQ1575; cd07390 1310161005984 Calcineurin-like phosphoesterase; Region: Metallophos; pfam00149 1310161005985 putative active site [active] 1310161005986 putative metal binding site [ion binding]; other site 1310161005987 Choline-glycine betaine transporter [Cell envelope biogenesis, outer membrane]; Region: BetT; COG1292 1310161005988 Lamin Tail Domain; Region: LTD; pfam00932 1310161005989 DctM-like transporters; Region: DctM; pfam06808 1310161005990 TRAP-type C4-dicarboxylate transport system, large permease component [Carbohydrate transport and metabolism]; Region: DctQ; COG1593 1310161005991 TRAP-type C4-dicarboxylate transport system, small permease component [Carbohydrate transport and metabolism]; Region: DctM; COG3090 1310161005992 TRAP-type C4-dicarboxylate transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: DctP; COG1638 1310161005993 Bacterial extracellular solute-binding protein, family 7; Region: SBP_bac_7; cl15441 1310161005994 GTP-binding protein LepA; Provisional; Region: PRK05433 1310161005995 LepA also known as Elongation Factor 4 (EF4); Region: LepA; cd01890 1310161005996 G1 box; other site 1310161005997 putative GEF interaction site [polypeptide binding]; other site 1310161005998 GTP/Mg2+ binding site [chemical binding]; other site 1310161005999 Switch I region; other site 1310161006000 G2 box; other site 1310161006001 G3 box; other site 1310161006002 Switch II region; other site 1310161006003 G4 box; other site 1310161006004 G5 box; other site 1310161006005 lepA_II: This subfamily represents the domain II of LepA, a GTP-binding protein localized in the cytoplasmic membrane. The N-terminal domain of LepA shares regions of homology to translation factors. In terms of interaction with the ribosome, EF-G, EF-Tu...; Region: lepA_II; cd03699 1310161006006 lepA_C: This family represents the C-terminal region of LepA, a GTP-binding protein localized in the cytoplasmic membrane. LepA is ubiquitous in Bacteria and Eukaryota (e.g. Saccharomyces cerevisiae GUF1p), but is missing from Archaea. LepA exhibits...; Region: lepA_C; cd03709 1310161006007 GTP-binding protein LepA C-terminus; Region: LepA_C; pfam06421 1310161006008 PemK-like protein; Region: PemK; pfam02452 1310161006009 30S ribosomal protein S20; Reviewed; Region: rpsT; PRK00239 1310161006010 Putative threonine efflux protein [Amino acid transport and metabolism]; Region: RhtB; COG1280 1310161006011 Ankyrin repeats (many copies); Region: Ank_4; pfam13637 1310161006012 ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other...; Region: ANK; cd00204 1310161006013 Ankyrin repeats (many copies); Region: Ank_4; pfam13637 1310161006014 hypothetical protein; Validated; Region: PRK05629 1310161006015 DNA polymerase III, delta subunit; Region: DNA_pol3_delta; pfam06144 1310161006016 Predicted membrane metal-binding protein [General function prediction only]; Region: ComEC; COG0658 1310161006017 Competence protein; Region: Competence; pfam03772 1310161006018 SLBB domain; Region: SLBB; pfam10531 1310161006019 Helix-hairpin-helix motif; Region: HHH_3; pfam12836 1310161006020 Helix-hairpin-helix motif; Region: HHH; pfam00633 1310161006021 Uncharacterized protein conserved in bacteria [Function unknown]; Region: DegV; COG1307 1310161006022 Uncharacterized protein, DegV family COG1307; Region: DegV; pfam02645 1310161006023 Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067 1310161006024 catalytic core [active] 1310161006025 Uncharacterized homolog of plant Iojap protein [Function unknown]; Region: COG0799 1310161006026 nicotinic acid mononucleotide adenylyltransferase; Provisional; Region: nadD; PRK00071 1310161006027 Nicotinamide/nicotinate mononucleotide adenylyltransferase; Region: NMNAT; cd02165 1310161006028 active site 1310161006029 (T/H)XGH motif; other site 1310161006030 Cutinase; Region: Cutinase; pfam01083 1310161006031 Gamma-glutamyl phosphate reductase (GPR), aldehyde dehydrogenase families 18 and 19; Region: ALDH_F18-19_ProA-GPR; cd07079 1310161006032 gamma-glutamyl phosphate reductase; Region: proA; TIGR00407 1310161006033 putative catalytic cysteine [active] 1310161006034 Putative D-isomer specific 2-hydroxyacid dehydrogenases; Region: 2-Hacid_dh_2; cd12159 1310161006035 Lactate dehydrogenase and related dehydrogenases [Energy production and conversion / Coenzyme metabolism / General function prediction only]; Region: LdhA; COG1052 1310161006036 putative ligand binding site [chemical binding]; other site 1310161006037 putative NAD binding site [chemical binding]; other site 1310161006038 catalytic site [active] 1310161006039 glutamate 5-kinase; Region: proB; TIGR01027 1310161006040 AAK_G5K_ProB: Glutamate-5-kinase (G5K) catalyzes glutamate-dependent ATP cleavage; G5K transfers the terminal phosphoryl group of ATP to the gamma-carboxyl group of glutamate, in the first and controlling step of proline (and, in mammals, ornithine)...; Region: AAK_G5K_ProB; cd04242 1310161006041 nucleotide binding site [chemical binding]; other site 1310161006042 homotetrameric interface [polypeptide binding]; other site 1310161006043 putative phosphate binding site [ion binding]; other site 1310161006044 putative allosteric binding site; other site 1310161006045 PUA domain; Region: PUA; pfam01472 1310161006046 GTPase CgtA; Reviewed; Region: obgE; PRK12296 1310161006047 GTP1/OBG; Region: GTP1_OBG; pfam01018 1310161006048 Obg GTPase; Region: Obg; cd01898 1310161006049 G1 box; other site 1310161006050 GTP/Mg2+ binding site [chemical binding]; other site 1310161006051 Switch I region; other site 1310161006052 G2 box; other site 1310161006053 G3 box; other site 1310161006054 Switch II region; other site 1310161006055 G4 box; other site 1310161006056 G5 box; other site 1310161006057 Domain of unknown function (DUF1967); Region: DUF1967; pfam09269 1310161006058 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 1310161006059 Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248 1310161006060 active site 1310161006061 catalytic tetrad [active] 1310161006062 Predicted nuclease of the RNAse H fold, HicB family [General function prediction only]; Region: HicB; COG4226 1310161006063 50S ribosomal protein L27; Validated; Region: rpmA; PRK05435 1310161006064 50S ribosomal protein L21; Validated; Region: rplU; PRK05573 1310161006065 50S ribosomal protein L21/unknown domain fusion protein; Provisional; Region: PRK12278 1310161006066 Translation initiation factor IF-2, N-terminal region; Region: IF2_N; pfam04760 1310161006067 ribonuclease, Rne/Rng family; Region: RNaseEG; TIGR00757 1310161006068 S1_RNase_E: RNase E and RNase G, S1-like RNA-binding domain. RNase E is an essential endoribonuclease in the processing and degradation of RNA. In addition to its role in mRNA degradation, RNase E has also been implicated in the processing of rRNA, and...; Region: S1_RNase_E; cd04453 1310161006069 homodimer interface [polypeptide binding]; other site 1310161006070 oligonucleotide binding site [chemical binding]; other site 1310161006072 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3464 1310161006073 Transposase; Region: DDE_Tnp_ISL3; pfam01610 1310161006075 Uncharacterized conserved protein [Function unknown]; Region: COG2128 1310161006076 Carboxymuconolactone decarboxylase family; Region: CMD; pfam02627 1310161006077 Nucleoside diphosphate kinase Group I (NDPk_I)-like: NDP kinase domains are present in a large family of structurally and functionally conserved proteins from bacteria to humans that generally catalyze the transfer of gamma-phosphates of a nucleoside...; Region: NDPk_I; cd04413 1310161006078 active site 1310161006079 multimer interface [polypeptide binding]; other site 1310161006080 Predicted acetyltransferase [General function prediction only]; Region: COG2388 1310161006081 START/RHO_alpha_C/PITP/Bet_v1/CoxG/CalC (SRPBCC) ligand-binding domain superfamily; Region: SRPBCC; cd07812 1310161006082 hydrophobic ligand binding site; other site 1310161006083 Protein of unknown function (DUF4233); Region: DUF4233; pfam14017 1310161006084 Folylpolyglutamate synthase [Coenzyme metabolism]; Region: FolC; COG0285 1310161006085 Mur ligase middle domain; Region: Mur_ligase_M; pfam08245 1310161006086 valyl-tRNA synthetase; Reviewed; Region: valS; PRK05729 1310161006087 nucleotidyl transferase superfamily; Region: nt_trans; cl00015 1310161006088 active site 1310161006089 HIGH motif; other site 1310161006090 nucleotide binding site [chemical binding]; other site 1310161006091 Leucyl-tRNA synthetase, Domain 2; Region: tRNA-synt_1_2; pfam13603 1310161006092 catalytic core domain of valyl-tRNA synthetases; Region: ValRS_core; cd00817 1310161006093 active site 1310161006094 KMSKS motif; other site 1310161006095 Anticodon-binding domain of valyl tRNA synthetases; Region: Anticodon_Ia_Val; cd07962 1310161006096 tRNA binding surface [nucleotide binding]; other site 1310161006097 anticodon binding site; other site 1310161006098 Valyl tRNA synthetase tRNA binding arm; Region: Val_tRNA-synt_C; pfam10458 1310161006099 ABC-type oligopeptide transport system, periplasmic component [Amino acid transport and metabolism]; Region: OppA; COG4166 1310161006100 The substrate-binding domain of an ABC-type nickel/oligopeptide-like import system contains the type 2 periplasmic binding fold; Region: PBP2_NikA_DppA_OppA_like; cd00995 1310161006101 Nucleotide-binding domain of the HSP70 family; Region: HSP70_NBD; cd10170 1310161006102 Actin-like ATPase involved in cell morphogenesis [Cell division and chromosome partitioning]; Region: MreB; COG1077 1310161006103 nucleotide binding site [chemical binding]; other site 1310161006104 putative NEF/HSP70 interaction site [polypeptide binding]; other site 1310161006105 SBD interface [polypeptide binding]; other site 1310161006106 Possible lysine decarboxylase; Region: Lysine_decarbox; cl00695 1310161006107 malate dehydrogenase; Provisional; Region: PRK05442 1310161006108 Chloroplast-like malate dehydrogenases; Region: MDH_choloroplast_like; cd01338 1310161006109 NAD(P) binding site [chemical binding]; other site 1310161006110 dimer interface [polypeptide binding]; other site 1310161006111 malate binding site [chemical binding]; other site 1310161006112 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 1310161006113 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 1310161006114 Predicted transcriptional regulators [Transcription]; Region: COG1695 1310161006115 Transcriptional regulator PadR-like family; Region: PadR; cl17335 1310161006116 Phenylpropionate dioxygenase and related ring-hydroxylating dioxygenases, large terminal subunit [Inorganic ion transport and metabolism / General function prediction only]; Region: HcaE; COG4638 1310161006117 Rieske domain; a [2Fe-2S] cluster binding domain commonly found in Rieske non-heme iron oxygenase (RO) systems such as naphthalene and biphenyl dioxygenases, as well as in plant/cyanobacterial chloroplast b6f and mitochondrial cytochrome bc(1) complexes; Region: Rieske; cl00938 1310161006118 iron-sulfur cluster [ion binding]; other site 1310161006119 [2Fe-2S] cluster binding site [ion binding]; other site 1310161006120 C-terminal catalytic domain of the oxygenase alpha subunit of dicamba O-demethylase and related aromatic ring hydroxylating dioxygenases; Region: RHO_alpha_C_DMO-like; cd08878 1310161006121 alpha subunit interface [polypeptide binding]; other site 1310161006122 active site 1310161006123 substrate binding site [chemical binding]; other site 1310161006124 Fe binding site [ion binding]; other site 1310161006125 Flavodoxin reductases (ferredoxin-NADPH reductases) family 1 [Energy production and conversion]; Region: Hmp; COG1018 1310161006126 Phthalate dioxygenase reductase (PDR) is an FMN-dependent reductase that mediates electron transfer from NADH to FMN to an iron sulfur cluster. PDR has an an N-terminal ferrredoxin reductase (FNR)-like NAD(H) binding domain and a C-terminal iron-sulfur; Region: PDR_like; cd06185 1310161006127 FMN-binding pocket [chemical binding]; other site 1310161006128 flavin binding motif; other site 1310161006129 phosphate binding motif [ion binding]; other site 1310161006130 beta-alpha-beta structure motif; other site 1310161006131 NAD binding pocket [chemical binding]; other site 1310161006132 2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207 1310161006133 Ferredoxin [Energy production and conversion]; Region: Fdx; COG0633 1310161006134 catalytic loop [active] 1310161006135 iron binding site [ion binding]; other site 1310161006136 benzoate transport; Region: 2A0115; TIGR00895 1310161006137 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1310161006138 putative substrate translocation pore; other site 1310161006139 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1310161006140 Predicted permeases [General function prediction only]; Region: COG0679 1310161006141 ATP-dependent protease ATP-binding subunit ClpX; Provisional; Region: clpX; PRK05342 1310161006142 ClpX C4-type zinc finger; Region: zf-C4_ClpX; smart00994 1310161006143 Magnesium chelatase, subunit ChlI; Region: Mg_chelatase; pfam01078 1310161006144 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 1310161006145 Walker A motif; other site 1310161006146 ATP binding site [chemical binding]; other site 1310161006147 Walker B motif; other site 1310161006148 C-terminal, D2-small domain, of ClpB protein; Region: ClpB_D2-small; smart01086 1310161006149 SGNH_hydrolase subfamily. SGNH hydrolases are a diverse family of lipases and esterases. The tertiary fold of the enzyme is substantially different from that of the alpha/beta hydrolase family and unique among all known hydrolases; its active site...; Region: SGNH_hydrolase_like_6; cd01844 1310161006150 active site 1310161006151 catalytic triad [active] 1310161006152 oxyanion hole [active] 1310161006153 3-oxoacid CoA-transferase, B subunit; Region: pcaJ_scoB_fam; TIGR02428 1310161006154 Acyl CoA:acetate/3-ketoacid CoA transferase, alpha subunit [Lipid metabolism]; Region: AtoD; COG1788 1310161006155 beta-ketoadipate pathway transcriptional regulators, PcaR/PcaU/PobR family; Region: pcaR_pcaU; TIGR02431 1310161006156 helix_turn_helix isocitrate lyase regulation; Region: HTH_ICLR; smart00346 1310161006157 Bacterial transcriptional regulator; Region: IclR; pfam01614 1310161006158 acetyl-CoA acetyltransferase; Provisional; Region: PRK06205 1310161006159 Thiolase are ubiquitous enzymes that catalyze the reversible thiolytic cleavage of 3-ketoacyl-CoA into acyl-CoA and acetyl-CoA, a 2-step reaction involving a covalent intermediate formed with a catalytic cysteine. They are found in prokaryotes and...; Region: thiolase; cd00751 1310161006160 dimer interface [polypeptide binding]; other site 1310161006161 active site 1310161006162 3-oxoadipate enol-lactonase; Region: protocat_pcaD; TIGR02427 1310161006163 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 1310161006164 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 1310161006165 DNA binding residues [nucleotide binding] 1310161006166 dimerization interface [polypeptide binding]; other site 1310161006167 4-carboxymuconolactone decarboxylase; Region: decarb_PcaC; TIGR02425 1310161006168 3-carboxy-cis,cis-muconate cycloisomerase; Region: protocat_pcaB; TIGR02426 1310161006169 Adenylosuccinate lyase [Nucleotide transport and metabolism]; Region: PurB; COG0015 1310161006170 tetramer interface [polypeptide binding]; other site 1310161006171 Protocatechuate 3,4-dioxygenase beta subunit [Secondary metabolites biosynthesis, transport, and catabolism]; Region: PcaH; COG3485 1310161006172 protocatechuate 3,4-dioxygenase, alpha subunit; Region: protocat_alph; TIGR02423 1310161006173 active site 1310161006174 protocatechuate 3,4-dioxygenase, beta subunit; Region: protocat_beta; TIGR02422 1310161006175 Intradiol dioxygenases catalyze the critical ring-cleavage step in the conversion of catecholate derivatives to citric acid cycle intermediates. This family contains catechol 1,2-dioxygenases and protocatechuate 3,4-dioxygenases which are mononuclear...; Region: intradiol_dioxygenase; cl17208 1310161006176 active site 1310161006177 HNH nucleases; HNH endonuclease signature which is found in viral, prokaryotic, and eukaryotic proteins. The alignment includes members of the large group of homing endonucleases, yeast intron 1 protein, MutS, as well as bacterial colicins, pyocins, and...; Region: HNHc; cd00085 1310161006178 active site 1310161006179 Muconolactone delta-isomerase [Secondary metabolites biosynthesis, transport, and catabolism]; Region: CatC1; COG4829 1310161006180 Enolase-superfamily, characterized by the presence of an enolate anion intermediate which is generated by abstraction of the alpha-proton of the carboxylate substrate by an active site residue and is stabilized by coordination to the essential Mg2+ ion; Region: enolase_like; cl17188 1310161006181 muconate and chloromuconate cycloisomerases; Region: mucon_cyclo; TIGR02534 1310161006182 metal binding site [ion binding]; metal-binding site 1310161006183 substrate binding pocket [chemical binding]; other site 1310161006184 catechol 1,2-dioxygenase, Actinobacterial; Region: catachol_actin; TIGR02438 1310161006185 Intradiol dioxygenases catalyze the critical ring-cleavage step in the conversion of catecholate derivatives to citric acid cycle intermediates. This family contains catechol 1,2-dioxygenases and protocatechuate 3,4-dioxygenases which are mononuclear...; Region: intradiol_dioxygenase; cl17208 1310161006186 active site 1310161006187 benzoate 1,2-dioxygenase, large subunit; Region: benzo_1_2_benA; TIGR03229 1310161006188 Rieske domain; a [2Fe-2S] cluster binding domain commonly found in Rieske non-heme iron oxygenase (RO) systems such as naphthalene and biphenyl dioxygenases, as well as in plant/cyanobacterial chloroplast b6f and mitochondrial cytochrome bc(1) complexes; Region: Rieske; cl00938 1310161006189 iron-sulfur cluster [ion binding]; other site 1310161006190 [2Fe-2S] cluster binding site [ion binding]; other site 1310161006191 C-terminal catalytic domain of the oxygenase alpha subunit of Pseudomonas resinovorans strain CA10 anthranilate 1,2-dioxygenase and related aromatic ring hydroxylating dioxygenases; Region: RHO_alpha_C_AntDO-like; cd08879 1310161006192 putative alpha subunit interface [polypeptide binding]; other site 1310161006193 putative active site [active] 1310161006194 putative substrate binding site [chemical binding]; other site 1310161006195 Fe binding site [ion binding]; other site 1310161006196 Ring hydroxylating dioxygenase beta subunit. This subunit has a similar structure to NTF-2, Ketosteroid isomerase and scytalone dehydratase.The degradation of aromatic compounds by aerobic bacteria frequently begins with the dihydroxylation of the...; Region: ring_hydroxylating_dioxygenases_beta; cd00667 1310161006197 inter-subunit interface; other site 1310161006198 anthranilate dioxygenase reductase; Provisional; Region: antC; PRK11872 1310161006199 2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207 1310161006200 catalytic loop [active] 1310161006201 iron binding site [ion binding]; other site 1310161006202 Benzoate dioxygenase reductase (BenDO) FAD/NAD binding domain. Oxygenases oxidize hydrocarbons using dioxygen as the oxidant. As a Class I bacterial dioxygenases, benzoate dioxygenase like proteins combine an [2Fe-2S] cluster containing N-terminal...; Region: BenDO_FAD_NAD; cd06209 1310161006203 FAD binding pocket [chemical binding]; other site 1310161006204 FAD binding motif [chemical binding]; other site 1310161006205 phosphate binding motif [ion binding]; other site 1310161006206 beta-alpha-beta structure motif; other site 1310161006207 NAD binding pocket [chemical binding]; other site 1310161006208 Transcriptional regulators [Transcription]; Region: FadR; COG2186 1310161006209 FCD domain; Region: FCD; pfam07729 1310161006210 1,6-dihydroxycyclohexa-2,4-diene-1-carboxylate dehydrogenase; Provisional; Region: benD; PRK12823 1310161006211 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 1310161006212 NAD(P) binding site [chemical binding]; other site 1310161006213 active site 1310161006214 AAA ATPase domain; Region: AAA_16; pfam13191 1310161006215 AAA domain; Region: AAA_22; pfam13401 1310161006216 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 1310161006217 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 1310161006218 DNA binding residues [nucleotide binding] 1310161006219 dimerization interface [polypeptide binding]; other site 1310161006220 benzoate transport; Region: 2A0115; TIGR00895 1310161006221 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1310161006222 putative substrate translocation pore; other site 1310161006223 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1310161006224 Uncharacterized protein involved in benzoate metabolism [Secondary metabolites biosynthesis, transport, and catabolism]; Region: BenE; COG3135 1310161006225 benzoate transporter; Region: benE; TIGR00843 1310161006226 ATP-dependent Clp protease proteolytic subunit; Reviewed; Region: PRK12553 1310161006227 Caseinolytic protease (ClpP) is an ATP-dependent, highly conserved serine protease; Region: S14_ClpP_2; cd07017 1310161006228 oligomer interface [polypeptide binding]; other site 1310161006229 active site residues [active] 1310161006230 Clp protease; Region: CLP_protease; pfam00574 1310161006231 Caseinolytic protease (ClpP) is an ATP-dependent, highly conserved serine protease; Region: S14_ClpP_2; cd07017 1310161006232 oligomer interface [polypeptide binding]; other site 1310161006233 active site residues [active] 1310161006234 trigger factor; Provisional; Region: tig; PRK01490 1310161006235 FKBP-type peptidyl-prolyl cis-trans isomerase; Region: FKBP_C; pfam00254 1310161006236 Bacterial trigger factor protein (TF) C-terminus; Region: Trigger_C; pfam05698 1310161006237 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 1310161006238 dimerization interface [polypeptide binding]; other site 1310161006239 putative DNA binding site [nucleotide binding]; other site 1310161006240 putative Zn2+ binding site [ion binding]; other site 1310161006241 Beta-lactamase; Region: Beta-lactamase; pfam00144 1310161006242 Beta-lactamase class C and other penicillin binding proteins [Defense mechanisms]; Region: AmpC; COG1680 1310161006243 RDD family; Region: RDD; pfam06271 1310161006244 Prophage CP4-57 regulatory protein (AlpA); Region: Phage_AlpA; cl17523 1310161006245 ribose-5-phosphate isomerase B; Provisional; Region: PRK05571 1310161006246 Predicted membrane protein [Function unknown]; Region: COG2311 1310161006247 Protein of unknown function (DUF418); Region: DUF418; pfam04235 1310161006248 DSBA-like thioredoxin domain; Region: DSBA; pfam01323 1310161006249 Protein Disulfide Oxidoreductases and Other Proteins with a Thioredoxin fold; Region: Thioredoxin_like; cl00388 1310161006250 aminopeptidase N, Streptomyces lividans type; Region: pepN_strep_liv; TIGR02412 1310161006251 Peptidase M1 family containing Aminopeptidase N; Region: M1_APN_3; cd09602 1310161006252 Zn binding site [ion binding]; other site 1310161006253 Uncharacterized conserved protein [Function unknown]; Region: COG4748 1310161006254 Type I restriction enzyme R protein N terminus (HSDR_N); Region: HSDR_N; cl14958 1310161006257 Trans-Isoprenyl Diphosphate Synthases, head-to-head; Region: Trans_IPPS_HH; cd00683 1310161006258 active site lid residues [active] 1310161006259 substrate binding pocket [chemical binding]; other site 1310161006260 catalytic residues [active] 1310161006261 substrate-Mg2+ binding site; other site 1310161006262 aspartate-rich region 1; other site 1310161006263 aspartate-rich region 2; other site 1310161006264 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1310161006265 putative substrate translocation pore; other site 1310161006266 Arabinose efflux permease [Carbohydrate transport and metabolism]; Region: AraJ; COG2814 1310161006267 CMD domain protein, Avi_7170 family; Region: CMD_Avi_7170; TIGR04029 1310161006268 alkylhydroperoxidase domain protein, Avi_7169 family; Region: perox_Avi_7169; TIGR04030 1310161006269 uncharacterized peroxidase-related enzyme; Region: peroxid_rel; TIGR01926 1310161006270 ATPase components of various ABC-type transport systems, contain duplicated ATPase [General function prediction only]; Region: COG1123 1310161006271 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 1310161006272 Walker A/P-loop; other site 1310161006273 ATP binding site [chemical binding]; other site 1310161006274 Q-loop/lid; other site 1310161006275 ABC transporter signature motif; other site 1310161006276 Walker B; other site 1310161006277 D-loop; other site 1310161006278 H-loop/switch region; other site 1310161006279 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097 1310161006280 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 1310161006281 Walker A/P-loop; other site 1310161006282 ATP binding site [chemical binding]; other site 1310161006283 Q-loop/lid; other site 1310161006284 ABC transporter signature motif; other site 1310161006285 Walker B; other site 1310161006286 D-loop; other site 1310161006287 H-loop/switch region; other site 1310161006288 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097 1310161006289 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppC; COG1173 1310161006290 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1310161006291 putative PBP binding loops; other site 1310161006292 dimer interface [polypeptide binding]; other site 1310161006293 ABC-ATPase subunit interface; other site 1310161006294 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppB; COG0601 1310161006295 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1310161006296 dimer interface [polypeptide binding]; other site 1310161006297 conserved gate region; other site 1310161006298 putative PBP binding loops; other site 1310161006299 ABC-ATPase subunit interface; other site 1310161006300 ABC-type dipeptide transport system, periplasmic component [Amino acid transport and metabolism]; Region: DdpA; COG0747 1310161006301 The substrate-binding component of an uncharacterized ABC-type nickel/dipeptide/oligopeptide-like import system contains the type 2 periplasmic binding fold; Region: PBP2_NikA_DppA_OppA_like_15; cd08492 1310161006302 FAD-NAD(P)-binding; Region: NAD_binding_9; pfam13454 1310161006303 hypothetical protein; Provisional; Region: PRK06062 1310161006304 Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610 1310161006305 inhibitor-cofactor binding pocket; inhibition site 1310161006306 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1310161006307 catalytic residue [active] 1310161006308 Domain of unknown function (DUF222); Region: DUF222; pfam02720 1310161006309 HNH nucleases; HNH endonuclease signature which is found in viral, prokaryotic, and eukaryotic proteins. The alignment includes members of the large group of homing endonucleases, yeast intron 1 protein, MutS, as well as bacterial colicins, pyocins, and...; Region: HNHc; cd00085 1310161006310 active site 1310161006311 Uncharacterized membrane-associated protein [Function unknown]; Region: DedA; COG0586 1310161006312 SNARE associated Golgi protein; Region: SNARE_assoc; cl00429 1310161006313 short chain dehydrogenase; Provisional; Region: PRK08219 1310161006314 HetN oxidoreductase-like, classical (c) SDR; Region: HetN_like_SDR_c; cd08932 1310161006315 putative NAD(P) binding site [chemical binding]; other site 1310161006316 active site 1310161006317 tetracycline repressor protein TetR; Provisional; Region: PRK13756 1310161006318 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 1310161006319 cystathionine gamma-synthase; Provisional; Region: PRK07811 1310161006320 CGS_like: Cystathionine gamma-synthase is a PLP dependent enzyme and catalyzes the committed step of methionine biosynthesis. This pathway is unique to microorganisms and plants, rendering the enzyme an attractive target for the development of...; Region: CGS_like; cd00614 1310161006321 homodimer interface [polypeptide binding]; other site 1310161006322 substrate-cofactor binding pocket; other site 1310161006323 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1310161006324 catalytic residue [active] 1310161006325 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 1310161006326 ABC-type cobalamin/Fe3+-siderophores transport systems, ATPase components [Inorganic ion transport and metabolism / Coenzyme metabolism]; Region: FepC; COG1120 1310161006327 Walker A/P-loop; other site 1310161006328 ATP binding site [chemical binding]; other site 1310161006329 Q-loop/lid; other site 1310161006330 ABC transporter signature motif; other site 1310161006331 Walker B; other site 1310161006332 D-loop; other site 1310161006333 H-loop/switch region; other site 1310161006334 Truncated hemoglobins (trHbs) are a family of oxygen-binding heme proteins found in cyanobacteria, eubacteria, unicellular eukaryotes, and plants. The truncated hemoglobins have a characteristic two-over-two alpha helical folding pattern that is distinct...; Region: Trunc_globin; cd00454 1310161006335 apolar tunnel; other site 1310161006336 heme binding site [chemical binding]; other site 1310161006337 dimerization interface [polypeptide binding]; other site 1310161006338 Chromate transport protein ChrA [Inorganic ion transport and metabolism]; Region: ChrA; COG2059 1310161006339 chromate transporter, chromate ion transporter (CHR) family; Region: 2A51; TIGR00937 1310161006340 Chromate transporter; Region: Chromate_transp; pfam02417 1310161006341 4-hydroxybenzoyl-CoA thioesterase (4HBT). Catalyzes the final step in the 4-chlorobenzoate degradation pathway in which 4-chlorobenzoate is converted to 4-hydroxybenzoate in certain soil-dwelling bacteria. 4HBT forms a homotetramer with four active sites; Region: 4HBT; cd00586 1310161006342 active site 1310161006343 Uncharacterized proteins of the AP superfamily [General function prediction only]; Region: COG1524 1310161006344 Type I phosphodiesterase / nucleotide pyrophosphatase; Region: Phosphodiest; pfam01663 1310161006345 putative ABC transporter ATP-binding protein; Reviewed; Region: PRK11819 1310161006346 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 1310161006347 Walker A/P-loop; other site 1310161006348 ATP binding site [chemical binding]; other site 1310161006349 Q-loop/lid; other site 1310161006350 ABC transporter signature motif; other site 1310161006351 Walker B; other site 1310161006352 D-loop; other site 1310161006353 H-loop/switch region; other site 1310161006354 ABC transporter; Region: ABC_tran_2; pfam12848 1310161006355 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 1310161006356 Single-stranded DNA-binding protein [DNA replication, recombination, and repair]; Region: Ssb; COG0629 1310161006357 SSB_OBF: A subfamily of OB folds similar to the OB fold of ssDNA-binding protein (SSB). SSBs bind with high affinity to ssDNA. They bind to and protect ssDNA intermediates during DNA metabolic pathways. All bacterial and eukaryotic SSBs studied to date...; Region: SSB_OBF; cd04496 1310161006358 dimer interface [polypeptide binding]; other site 1310161006359 ssDNA binding site [nucleotide binding]; other site 1310161006360 tetramer (dimer of dimers) interface [polypeptide binding]; other site 1310161006361 Copper resistance protein D; Region: CopD; cl00563 1310161006362 Predicted membrane protein [Function unknown]; Region: COG3336 1310161006363 Alkaline phosphatase [Inorganic ion transport and metabolism]; Region: PhoA; COG1785 1310161006364 Alkaline phosphatase homologues; alkaline phosphatases are non-specific phosphomonoesterases that catalyze the hydrolysis reaction via a phosphoseryl intermediate to produce inorganic phosphate and the corresponding alcohol, optimally at high pH; Region: alkPPc; cl15837 1310161006365 active site 1310161006366 dimer interface [polypeptide binding]; other site 1310161006367 ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395 1310161006368 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1310161006369 dimer interface [polypeptide binding]; other site 1310161006370 conserved gate region; other site 1310161006371 putative PBP binding loops; other site 1310161006372 ABC-ATPase subunit interface; other site 1310161006373 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1310161006374 dimer interface [polypeptide binding]; other site 1310161006375 conserved gate region; other site 1310161006376 putative PBP binding loops; other site 1310161006377 ABC-ATPase subunit interface; other site 1310161006378 ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653 1310161006379 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; pfam01547 1310161006380 Lipopolysaccharide kinase (Kdo/WaaP) family; Region: Kdo; cl17488 1310161006381 Domain of unknown function (DUF4032); Region: DUF4032; pfam13224 1310161006382 glycerol-3-phosphate transporter ATP-binding subunit; Provisional; Region: ugpC; PRK11650 1310161006383 The N-terminal ATPase domain of the maltose transporter, MalK; Region: ABC_MalK_N; cd03301 1310161006384 Walker A/P-loop; other site 1310161006385 ATP binding site [chemical binding]; other site 1310161006386 Q-loop/lid; other site 1310161006387 ABC transporter signature motif; other site 1310161006388 Walker B; other site 1310161006389 D-loop; other site 1310161006390 H-loop/switch region; other site 1310161006393 C2 domain; Region: C2; cl14603 1310161006394 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 1310161006395 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 1310161006397 Medium chain reductase/dehydrogenase (MDR)/zinc-dependent alcohol dehydrogenase-like family; Region: MDR; cl16912 1310161006398 Zn-dependent alcohol dehydrogenases, class III [Energy production and conversion]; Region: AdhC; COG1062 1310161006399 NCAIR mutase (PurE)-related proteins [General function prediction only]; Region: COG1691 1310161006400 AIR carboxylase; Region: AIRC; smart01001 1310161006401 Uncharacterized conserved protein [Function unknown]; Region: COG1641 1310161006402 Hydroxypyruvate isomerase [Carbohydrate transport and metabolism]; Region: Hfi; COG3622 1310161006403 Short-chain dehydrogenases of various substrate specificities [General function prediction only]; Region: DltE; COG0300 1310161006404 classical (c) SDRs; Region: SDR_c; cd05233 1310161006405 NAD(P) binding site [chemical binding]; other site 1310161006406 active site 1310161006407 DNA polymerase III, epsilon subunit and related 3'-5' exonucleases [DNA replication, recombination, and repair]; Region: DnaQ; COG0847 1310161006408 DEDDh 3'-5' exonuclease domain of oligoribonuclease and similar proteins; Region: Orn; cd06135 1310161006409 catalytic site [active] 1310161006410 putative active site [active] 1310161006411 putative substrate binding site [chemical binding]; other site 1310161006412 dimer interface [polypeptide binding]; other site 1310161006413 Domain of unknown function (DUF3327); Region: DUF3327; pfam11806 1310161006414 Enterochelin esterase and related enzymes [Inorganic ion transport and metabolism]; Region: Fes; COG2382 1310161006415 IgD-like repeat domain of mycobacterial L,D-transpeptidases; Region: LDT_IgD_like; cl17506 1310161006416 IgD-like repeat domain of mycobacterial L,D-transpeptidases; Region: LDT_IgD_like_2; cd13432 1310161006417 Uncharacterized protein conserved in bacteria [Function unknown]; Region: ErfK; COG1376 1310161006418 L,D-transpeptidase catalytic domain; Region: YkuD; pfam03734 1310161006419 Ankyrin repeats (many copies); Region: Ank_5; pfam13857 1310161006420 ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other...; Region: ANK; cd00204 1310161006422 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3464 1310161006423 Transposase; Region: DDE_Tnp_ISL3; pfam01610 1310161006424 Glutaminase [Amino acid transport and metabolism]; Region: GlsA; COG2066 1310161006425 glutaminase; Provisional; Region: PRK00971 1310161006426 Sulphate Transporter and Anti-Sigma factor antagonist domain found in the C-terminal region of sulphate transporters as well as in bacterial and archaeal proteins involved in the regulation of sigma factors; Region: STAS; cl00604 1310161006430 glucuronate isomerase; Reviewed; Region: PRK02925 1310161006431 Glucuronate isomerase [Carbohydrate transport and metabolism]; Region: UxaC; COG1904 1310161006432 Gluconate kinase (GntK) catalyzes the phosphoryl transfer from ATP to gluconate. The resulting product gluconate-6-phoshate is an important precursor of gluconate metabolism. GntK acts as a dimmer composed of two identical subunits; Region: GntK; cd02021 1310161006433 Restriction endonuclease [Defense mechanisms]; Region: McrA; COG1403 1310161006434 HNH nucleases; HNH endonuclease signature which is found in viral, prokaryotic, and eukaryotic proteins. The alignment includes members of the large group of homing endonucleases, yeast intron 1 protein, MutS, as well as bacterial colicins, pyocins, and...; Region: HNHc; cd00085 1310161006435 active site 1310161006436 Nicotinamidase/pyrazinamidase (PZase). Nicotinamidase, a ubiquitous enzyme in prokaryotes, converts nicotinamide to nicotinic acid (niacin) and ammonia, which in turn can be recycled to make nicotinamide adenine dinucleotide (NAD). The same enzyme is...; Region: nicotinamidase; cd01011 1310161006437 Isochorismatase family; Region: Isochorismatase; pfam00857 1310161006438 catalytic triad [active] 1310161006439 metal binding site [ion binding]; metal-binding site 1310161006440 conserved cis-peptide bond; other site 1310161006441 Protein of unknown function (DUF3618); Region: DUF3618; pfam12277 1310161006442 Peroxiredoxin [Posttranslational modification, protein turnover, chaperones]; Region: AhpC; COG0450 1310161006443 Peroxiredoxin (PRX) family, Bacterioferritin comigratory protein (BCP) subfamily; composed of thioredoxin-dependent thiol peroxidases, widely expressed in pathogenic bacteria, that protect cells against toxicity from reactive oxygen species by reducing...; Region: PRX_BCP; cd03017 1310161006444 catalytic triad [active] 1310161006445 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 1310161006446 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 1310161006447 4'-phosphopantetheinyl transferase; Provisional; Region: acpS; PRK00070 1310161006448 drug resistance transporter, EmrB/QacA subfamily; Region: efflux_EmrB; TIGR00711 1310161006449 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1310161006450 putative substrate translocation pore; other site 1310161006451 (acyl-carrier-protein) S-malonyltransferase [Lipid metabolism]; Region: FabD; COG0331 1310161006452 Enoyl reductase domain of yeast-type FAS1 [Lipid metabolism]; Region: COG4981 1310161006453 TIM barrel proteins share a structurally conserved phosphate binding motif and in general share an eight beta/alpha closed barrel structure. Specific for this family is the conserved phosphate binding site at the edges of strands 7 and 8. The phosphate...; Region: TIM_phosphate_binding; cl17186 1310161006454 phosphate binding site [ion binding]; other site 1310161006455 Domain of unknown function (DUF1729); Region: DUF1729; pfam08354 1310161006456 The hotdog fold was initially identified in the E. coli FabA (beta-hydroxydecanoyl-acyl carrier protein (ACP)-dehydratase) structure and subsequently in 4HBT (4-hydroxybenzoyl-CoA thioesterase) from Pseudomonas. A number of other seemingly unrelated...; Region: hot_dog; cl00509 1310161006457 active site 2 [active] 1310161006458 active site 1 [active] 1310161006459 (acyl-carrier-protein) S-malonyltransferase [Lipid metabolism]; Region: FabD; COG0331 1310161006460 malonyl CoA-acyl carrier protein transacylase; Region: fabD; TIGR00128 1310161006461 3-oxoacyl-[acyl-carrier protein]; Region: COG4982 1310161006462 ketoacyl reductase (KR) domain of fungal-type fatty acid synthase (fFAS), classical (c)-like SDRs; Region: KR_fFAS_SDR_c_like; cd08950 1310161006463 putative NAD(P) binding site [chemical binding]; other site 1310161006464 active site 1310161006465 "elongating" condensing enzymes are a subclass of decarboxylating condensing enzymes, including beta-ketoacyl [ACP] synthase, type I and II and polyketide synthases.They are characterized by the utlization of acyl carrier protein (ACP)...; Region: elong_cond_enzymes; cd00828 1310161006466 3-oxoacyl-(acyl-carrier-protein) synthase [Lipid metabolism / Secondary metabolites biosynthesis, transport, and catabolism]; Region: FabB; COG0304 1310161006467 active site 1310161006468 Regulator of polyketide synthase expression [Signal transduction mechanisms / Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG2508 1310161006469 PucR C-terminal helix-turn-helix domain; Region: HTH_30; pfam13556 1310161006470 Membrane proteins related to metalloendopeptidases [Cell envelope biogenesis, outer membrane]; Region: NlpD; COG0739 1310161006471 Peptidase family M23; Region: Peptidase_M23; pfam01551 1310161006472 Glucitol operon activator [Transcription]; Region: GutM; COG4578 1310161006473 Domain of unknown function (DUF3817); Region: DUF3817; pfam12823 1310161006474 NTPase/HAM1. This family consists of the HAM1 protein and pyrophosphate-releasing xanthosine/ inosine triphosphatase. HAM1 protects the cell against mutagenesis by the base analog 6-N-hydroxylaminopurine (HAP) in E. Coli and S. cerevisiae. A...; Region: HAM1; cd00515 1310161006475 active site 1310161006476 dimerization interface [polypeptide binding]; other site 1310161006477 ribonuclease PH; Reviewed; Region: rph; PRK00173 1310161006478 Ribonuclease PH; Region: RNase_PH_bact; cd11362 1310161006479 hexamer interface [polypeptide binding]; other site 1310161006480 active site 1310161006481 DDE domain; Region: DDE_Tnp_IS240; pfam13610 1310161006482 Integrase core domain; Region: rve; pfam00665 1310161006483 DDE domain; Region: DDE_Tnp_IS240; pfam13610 1310161006484 Integrase core domain; Region: rve; pfam00665 1310161006486 Metal-dependent hydrolases of the beta-lactamase superfamily III [General function prediction only]; Region: ElaC; COG1234 1310161006487 helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347 1310161006488 MarR family; Region: MarR; pfam01047 1310161006489 Membrane associated serine protease [Amino acid transport and metabolism]; Region: COG0705 1310161006490 nylC-like family; composed of proteins with similarity to Flavobacterium endo-type 6-aminohexanoate-oligomer hydrolase (EIII), the product of the nylon oligomer degradation gene, nylC. EIII is an amide hydrolase that catalyzes the degradation of...; Region: nylC_like; cd02252 1310161006491 putative active site pocket [active] 1310161006492 cleavage site 1310161006493 Domain of unknown function (DUF2017); Region: DUF2017; pfam09438 1310161006494 ATP-dependent Clp protease adaptor protein ClpS; Reviewed; Region: clpS; PRK00033 1310161006495 Uncharacterized protein with SCP/PR1 domains [Function unknown]; Region: COG2340 1310161006496 SCP_bacterial: SCP-like extracellular protein domain, as found in bacteria and archaea. The wider family of SCP containing proteins includes plant pathogenesis-related protein 1 (PR-1), CRISPs, mammalian cysteine-rich secretory proteins, and allergen 5...; Region: SCP_bacterial; cd05379 1310161006497 nicotinate phosphoribosyltransferase; Validated; Region: PRK09243 1310161006498 Nicotinate phosphoribosyltransferase (NAPRTase), subgroup A. Nicotinate phosphoribosyltransferase catalyses the formation of NAMN and PPi from 5-phosphoribosy -1-pyrophosphate (PRPP) and nicotinic acid, this is the first, and also rate limiting, reaction...; Region: NAPRTase_A; cd01570 1310161006499 active site 1310161006500 Rad3-related DNA helicases [Transcription / DNA replication, recombination, and repair]; Region: DinG; COG1199 1310161006501 DEAD/DEAH box helicase; Region: DEAD; pfam00270 1310161006502 DEAD_2; Region: DEAD_2; pfam06733 1310161006503 Helicase C-terminal domain; Region: Helicase_C_2; pfam13307 1310161006504 Prion/Doppel alpha-helical domain; Region: Prion; cl02493 1310161006505 Predicted integral membrane protein (DUF2189); Region: DUF2189; cl02291 1310161006506 Peptidyl-tRNA hydrolase [Translation, ribosomal structure and biogenesis]; Region: pth2; COG1990 1310161006507 CT domains found N-terminal of phosphoserine phosphatase (PSP, SerB); Region: ACT_PSP_1; cd04870 1310161006508 ACT domains found N-terminal of phosphoserine phosphatase (PSP, SerB); Region: ACT_PSP_2; cd04871 1310161006509 phosphoserine phosphatase SerB; Region: serB; TIGR00338 1310161006510 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 1310161006511 motif II; other site 1310161006512 Ubiquinol oxidase subunit I. Ubiquinol oxidase, the terminal oxidase in the respiratory chains of aerobic bacteria, is a multi-chain transmembrane protein located in the cell membrane. It catalyzes the reduction of O2 and simultaneously pumps protons...; Region: Ubiquinol_Oxidase_I; cd01662 1310161006513 Heme/copper-type cytochrome/quinol oxidases, subunit 1 [Energy production and conversion]; Region: CyoB; COG0843 1310161006514 D-pathway; other site 1310161006515 Putative ubiquinol binding site [chemical binding]; other site 1310161006516 Low-spin heme (heme b) binding site [chemical binding]; other site 1310161006517 Putative water exit pathway; other site 1310161006518 Binuclear center (heme o3/CuB) [ion binding]; other site 1310161006519 K-pathway; other site 1310161006520 Putative proton exit pathway; other site 1310161006521 ribonucleotide-diphosphate reductase subunit beta; Provisional; Region: nrdF2; PRK13966 1310161006522 Ribonucleotide Reductase, R2/beta subunit, ferritin-like diiron-binding domain; Region: RNRR2; cd01049 1310161006523 dimer interface [polypeptide binding]; other site 1310161006524 putative radical transfer pathway; other site 1310161006525 diiron center [ion binding]; other site 1310161006526 tyrosyl radical; other site 1310161006527 nonheme-containing ferritins; Region: Nonheme_Ferritin; cd01055 1310161006528 Ferritin-like domain; Region: Ferritin; pfam00210 1310161006529 ferroxidase diiron center [ion binding]; other site 1310161006530 Transcriptional regulators [Transcription]; Region: FadR; COG2186 1310161006531 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 1310161006532 DNA-binding site [nucleotide binding]; DNA binding site 1310161006533 This entry represents the C-terminal ligand binding domain of many members of the GntR family; Region: FCD; smart00895 1310161006534 Mn-dependent transcriptional regulator [Transcription]; Region: TroR; COG1321 1310161006535 helix_turn_helix, cAMP Regulatory protein C-terminus; DNA binding domain of prokaryotic regulatory proteins belonging to the catabolite activator protein family; Region: HTH_CRP; cd00092 1310161006536 non-specific DNA interactions [nucleotide binding]; other site 1310161006537 DNA binding site [nucleotide binding] 1310161006538 sequence specific DNA binding site [nucleotide binding]; other site 1310161006539 putative cAMP binding site [chemical binding]; other site 1310161006540 Iron dependent repressor, metal binding and dimerisation domain; Region: Fe_dep_repr_C; pfam02742 1310161006541 ribonucleotide-diphosphate reductase subunit alpha; Validated; Region: PRK08188 1310161006542 Ribonucleotide reductase N-terminal; Region: RNR_N; pfam08343 1310161006543 Class I ribonucleotide reductase; Region: RNR_I; cd01679 1310161006544 active site 1310161006545 dimer interface [polypeptide binding]; other site 1310161006546 catalytic residues [active] 1310161006547 effector binding site; other site 1310161006548 R2 peptide binding site; other site 1310161006549 ribonucleotide reductase stimulatory protein; Reviewed; Region: nrdI; PRK03600 1310161006550 NrdH-redoxin (NrdH) family; NrdH is a small monomeric protein with a conserved redox active CXXC motif within a TRX fold, characterized by a glutaredoxin (GRX)-like sequence and TRX-like activity profile. In vitro, it displays protein disulfide reductase...; Region: NrdH; cd02976 1310161006551 catalytic residues [active] 1310161006552 50S ribosomal protein L36; Validated; Region: rpmJ; PRK00831 1310161006553 NAD synthase [Coenzyme metabolism]; Region: NadE; COG0171 1310161006554 NAD+ synthase is a homodimer, which catalyzes the final step in de novo nicotinamide adenine dinucleotide (NAD+) biosynthesis, an amide transfer from either ammonia or glutamine to nicotinic acid adenine dinucleotide (NaAD). The conversion of NaAD to NAD...; Region: NAD_synthase; cd00553 1310161006555 homodimer interface [polypeptide binding]; other site 1310161006556 NAD binding pocket [chemical binding]; other site 1310161006557 ATP binding pocket [chemical binding]; other site 1310161006558 Mg binding site [ion binding]; other site 1310161006559 active-site loop [active] 1310161006560 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3001 1310161006561 Phosphotransferase enzyme family; Region: APH; pfam01636 1310161006562 Pyridoxamine 5'-phosphate oxidase; Region: Pyridox_ox_2; pfam12900 1310161006563 Yhdh putative quinone oxidoreductases; Region: MDR_yhdh; cd08288 1310161006564 putative quinone oxidoreductase, YhdH/YhfP family; Region: oxido_YhdH; TIGR02823 1310161006565 NADP binding site [chemical binding]; other site 1310161006566 dimer interface [polypeptide binding]; other site 1310161006567 Uncharacterized protein involved in propionate catabolism [General function prediction only]; Region: PrpD; COG2079 1310161006568 (2R)-phospho-3-sulfolactate synthase (PSL synthase, CoM biosynthesis) [Coenzyme transport and metabolism]; Region: COG1809 1310161006569 Protein-disulfide isomerase [Posttranslational modification, protein turnover, chaperones]; Region: DsbG; COG1651 1310161006570 phosphoglucomutase; Validated; Region: PRK07564 1310161006571 This bacterial PGM-like (phosphoglucomutase-like) protein of unknown function belongs to the alpha-D-phosphohexomutase superfamily. The alpha-D-phosphohexomutases include several related enzymes that catalyze a reversible intramolecular phosphoryl...; Region: PGM_like3; cd05801 1310161006572 active site 1310161006573 substrate binding site [chemical binding]; other site 1310161006574 metal binding site [ion binding]; metal-binding site 1310161006577 hypothetical protein; Provisional; Region: PRK05463 1310161006578 Transposase DDE domain; Region: DDE_Tnp_1; pfam01609 1310161006579 Uncharacterized protein potentially involved in peptidoglycan biosynthesis [Cell envelope biogenesis, outer membrane]; Region: COG5479 1310161006580 LGFP repeat; Region: LGFP; pfam08310 1310161006581 LGFP repeat; Region: LGFP; pfam08310 1310161006582 LGFP repeat; Region: LGFP; pfam08310 1310161006583 exopolysaccharide biosynthesis polyprenyl glycosylphosphotransferase; Region: EPS_sugtrans; TIGR03025 1310161006585 Transposase DDE domain; Region: DDE_Tnp_1; pfam01609 1310161006586 Predicted membrane protein [General function prediction only]; Region: COG4194 1310161006587 Protein of unknown function (DUF1648); Region: DUF1648; pfam07853 1310161006588 Sodium:dicarboxylate symporter family; Region: SDF; pfam00375 1310161006589 Na+/H+-dicarboxylate symporters [Energy production and conversion]; Region: GltP; COG1301 1310161006590 ABC-type transport system, involved in lipoprotein release, permease component [Cell envelope biogenesis, outer membrane]; Region: LolE; COG4591 1310161006591 MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704 1310161006592 FtsX-like permease family; Region: FtsX; pfam02687 1310161006593 MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704 1310161006594 FtsX-like permease family; Region: FtsX; pfam02687 1310161006595 ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255 1310161006596 ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136 1310161006597 Walker A/P-loop; other site 1310161006598 ATP binding site [chemical binding]; other site 1310161006599 Q-loop/lid; other site 1310161006600 ABC transporter signature motif; other site 1310161006601 Walker B; other site 1310161006602 D-loop; other site 1310161006603 H-loop/switch region; other site 1310161006604 Sugar phosphate isomerases/epimerases [Carbohydrate transport and metabolism]; Region: IolE; COG1082 1310161006605 Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408 1310161006606 Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673 1310161006607 Oxidoreductase family, C-terminal alpha/beta domain; Region: GFO_IDH_MocA_C; pfam02894 1310161006608 Methyltransferase domain; Region: Methyltransf_23; pfam13489 1310161006609 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 1310161006610 S-adenosylmethionine binding site [chemical binding]; other site 1310161006611 UDP-N-acetylglucosamine 1-carboxyvinyltransferase; Region: murA; TIGR01072 1310161006612 UDP-N-acetylglucosamine enolpyruvyl transferase catalyzes enolpyruvyl transfer as part of the first step in the biosynthesis of peptidoglycan, a component of the bacterial cell wall. The reaction is phosphoenolpyruvate + UDP-N-acetyl-D-glucosamine =...; Region: UdpNAET; cd01555 1310161006613 hinge; other site 1310161006614 active site 1310161006615 cob(I)alamin adenosyltransferase [Coenzyme transport and metabolism]; Region: COG2096 1310161006616 GAF domain; Region: GAF_2; pfam13185 1310161006617 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 1310161006618 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 1310161006619 DNA binding residues [nucleotide binding] 1310161006620 dimerization interface [polypeptide binding]; other site 1310161006621 Cysteine synthase [Amino acid transport and metabolism]; Region: CysK; COG0031 1310161006622 CBS_like: This subgroup includes Cystathionine beta-synthase (CBS) and Cysteine synthase. CBS is a unique heme-containing enzyme that catalyzes a pyridoxal 5'-phosphate (PLP)-dependent condensation of serine and homocysteine to give cystathionine; Region: CBS_like; cd01561 1310161006623 dimer interface [polypeptide binding]; other site 1310161006624 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1310161006625 catalytic residue [active] 1310161006626 serine O-acetyltransferase; Region: cysE; TIGR01172 1310161006627 Serine acetyltransferase (SAT): SAT catalyzes the CoA-dependent acetylation of the side chain hydroxyl group of L-serine to form O-acetylserine, as the first step of a two-step biosynthetic pathway in bacteria and plants leading to the formation of...; Region: LbH_SAT; cd03354 1310161006628 trimer interface [polypeptide binding]; other site 1310161006629 active site 1310161006630 substrate binding site [chemical binding]; other site 1310161006631 CoA binding site [chemical binding]; other site 1310161006632 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 1310161006633 Coenzyme A binding pocket [chemical binding]; other site 1310161006634 succinyl-CoA synthetase subunit alpha; Validated; Region: PRK05678 1310161006635 CoA binding domain; Region: CoA_binding; smart00881 1310161006636 CoA-ligase; Region: Ligase_CoA; pfam00549 1310161006637 succinyl-CoA synthetase subunit beta; Provisional; Region: sucC; PRK00696 1310161006638 ATP-grasp domain; Region: ATP-grasp_2; pfam08442 1310161006639 CoA-ligase; Region: Ligase_CoA; pfam00549 1310161006640 Predicted dithiol-disulfide isomerase involved in polyketide biosynthesis [Secondary metabolites biosynthesis, transport, and catabolism]; Region: FrnE; COG2761 1310161006641 DsbA family, FrnE subfamily; FrnE is a DsbA-like protein containing a CXXC motif. It is presumed to be a thiol oxidoreductase involved in polyketide biosynthesis, specifically in the production of the aromatic antibiotics frenolicin and nanaomycins; Region: DsbA_FrnE; cd03024 1310161006642 catalytic residues [active] 1310161006643 Lysophospholipase [Lipid metabolism]; Region: PldB; COG2267 1310161006644 Acetyl-CoA hydrolase/transferase N-terminal domain; Region: AcetylCoA_hydro; pfam02550 1310161006645 succinate CoA transferase; Region: YgfH_subfam; TIGR03458 1310161006646 Acetyl-CoA hydrolase/transferase C-terminal domain; Region: AcetylCoA_hyd_C; pfam13336 1310161006647 putative TIM-barrel protein, nifR3 family; Region: nifR3_yhdG; TIGR00737 1310161006648 Dihydrouridine synthase-like (DUS-like) FMN-binding domain. Members of this family catalyze the reduction of the 5,6-double bond of a uridine residue on tRNA. Dihydrouridine modification of tRNA is widely observed in prokaryotes and eukaryotes, and also...; Region: DUS_like_FMN; cd02801 1310161006649 FMN binding site [chemical binding]; other site 1310161006650 active site 1310161006651 catalytic residues [active] 1310161006652 substrate binding site [chemical binding]; other site 1310161006653 Phosphate uptake regulator [Inorganic ion transport and metabolism]; Region: PhoU; COG0704 1310161006654 PhoU domain; Region: PhoU; pfam01895 1310161006655 PhoU domain; Region: PhoU; pfam01895 1310161006656 phosphate transporter ATP-binding protein; Provisional; Region: PRK14241 1310161006657 ATP-binding cassette domain of the phosphate transport system; Region: ABC_PstB_phosphate_transporter; cd03260 1310161006658 Walker A/P-loop; other site 1310161006659 ATP binding site [chemical binding]; other site 1310161006660 Q-loop/lid; other site 1310161006661 ABC transporter signature motif; other site 1310161006662 Walker B; other site 1310161006663 D-loop; other site 1310161006664 H-loop/switch region; other site 1310161006665 ABC-type phosphate transport system, permease component [Inorganic ion transport and metabolism]; Region: PstA; COG0581 1310161006666 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1310161006667 dimer interface [polypeptide binding]; other site 1310161006668 conserved gate region; other site 1310161006669 putative PBP binding loops; other site 1310161006670 ABC-ATPase subunit interface; other site 1310161006671 ABC-type phosphate transport system, permease component [Inorganic ion transport and metabolism]; Region: PstC; COG0573 1310161006672 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1310161006673 dimer interface [polypeptide binding]; other site 1310161006674 conserved gate region; other site 1310161006675 putative PBP binding loops; other site 1310161006676 ABC-ATPase subunit interface; other site 1310161006677 PBP superfamily domain; Region: PBP_like_2; cl17296 1310161006678 mycothiol synthase; Region: mycothiol_MshD; TIGR03448 1310161006679 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 1310161006680 Coenzyme A binding pocket [chemical binding]; other site 1310161006681 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 1310161006682 Coenzyme A binding pocket [chemical binding]; other site 1310161006683 Protein of unknown function (DUF2993); Region: DUF2993; pfam11209 1310161006684 nitrobindin heme-binding domain; Region: nitrobindin; cd07828 1310161006685 heme-binding site [chemical binding]; other site 1310161006686 Branched-chain amino acid aminotransferase/4-amino-4-deoxychorismate lyase [Amino acid transport and metabolism / Coenzyme metabolism]; Region: IlvE; COG0115 1310161006687 ADCL_like: 4-Amino-4-deoxychorismate lyase: is a member of the fold-type IV of PLP dependent enzymes that converts 4-amino-4-deoxychorismate (ADC) to p-aminobenzoate and pyruvate. Based on the information available from the crystal structure, most...; Region: ADCL_like; cd01559 1310161006688 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1310161006689 catalytic residue [active] 1310161006690 Predicted aminomethyltransferase related to GcvT [General function prediction only]; Region: COG0354 1310161006691 folate-binding protein YgfZ; Region: ygfZ_signature; TIGR03317 1310161006692 Glycine cleavage T-protein C-terminal barrel domain; Region: GCV_T_C; pfam08669 1310161006694 Transposase and inactivated derivatives, IS30 family [DNA replication, recombination, and repair]; Region: Tra8; COG2826 1310161006695 Helix-turn-helix domain; Region: HTH_38; pfam13936 1310161006696 Homeodomain-like domain; Region: HTH_32; pfam13565 1310161006697 Integrase core domain; Region: rve; pfam00665 1310161006698 phosphoribosylaminoimidazole synthetase; Provisional; Region: PRK05385 1310161006699 PurM (Aminoimidazole Ribonucleotide [AIR] synthetase), one of eleven enzymes required for purine biosynthesis, catalyzes the conversion of formylglycinamide ribonucleotide (FGAM) and ATP to AIR, ADP, and Pi, the fifth step in de novo purine biosynthesis; Region: PurM; cd02196 1310161006700 dimerization interface [polypeptide binding]; other site 1310161006701 putative ATP binding site [chemical binding]; other site 1310161006702 amidophosphoribosyltransferase; Provisional; Region: PRK07847 1310161006703 Glutamine amidotransferases class-II (GN-AT)_GPAT- type. This domain is found at the N-terminus of glutamine phosphoribosylpyrophosphate (Prpp) amidotransferase (GPATase) . The glutaminase domain catalyzes amide nitrogen transfer from glutamine to the...; Region: GPATase_N; cd00715 1310161006704 active site 1310161006705 tetramer interface [polypeptide binding]; other site 1310161006706 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 1310161006707 active site 1310161006708 Brown fat-inducible thioesterase (BFIT). Brain acyl-CoA hydrolase (BACH). These enzymes deacylate long-chain fatty acids by hydrolyzing acyl-CoA thioesters to free fatty acids and CoA-SH. Eukaryotic members of this family are expressed in brain, testis; Region: BFIT_BACH; cd03442 1310161006709 Brown fat-inducible thioesterase (BFIT). Brain acyl-CoA hydrolase (BACH). These enzymes deacylate long-chain fatty acids by hydrolyzing acyl-CoA thioesters to free fatty acids and CoA-SH. Eukaryotic members of this family are expressed in brain, testis; Region: BFIT_BACH; cd03442 1310161006710 Predicted membrane protein, hemolysin III homolog [General function prediction only]; Region: COG1272 1310161006711 channel protein, hemolysin III family; Region: hlyIII; TIGR01065 1310161006712 phosphoribosylformylglycinamidine synthase II; Provisional; Region: PRK01213 1310161006713 PurL subunit of the formylglycinamide ribonucleotide amidotransferase (FGAR-AT), first repeat. FGAR-AT catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to formylglycinamidine ribonucleotide (FGAM), ADP; Region: PurL_repeat1; cd02203 1310161006714 dimerization interface [polypeptide binding]; other site 1310161006715 ATP binding site [chemical binding]; other site 1310161006716 PurL subunit of the formylglycinamide ribonucleotide amidotransferase (FGAR-AT), second repeat. FGAR-AT catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to formylglycinamidine ribonucleotide (FGAM), ADP; Region: PurL_repeat2; cd02204 1310161006717 dimerization interface [polypeptide binding]; other site 1310161006718 ATP binding site [chemical binding]; other site 1310161006719 phosphoribosylformylglycinamidine synthase I; Provisional; Region: PRK03619 1310161006720 Type 1 glutamine amidotransferase (GATase1)-like domain found in Formylglycinamide ribonucleotide amidotransferase; Region: GATase1_FGAR_AT; cd01740 1310161006721 putative active site [active] 1310161006722 catalytic triad [active] 1310161006723 phosphoribosylformylglycinamidine synthase subunit PurS; Reviewed; Region: PRK05974 1310161006724 Glutathione (GSH) peroxidase family; tetrameric selenoenzymes that catalyze the reduction of a variety of hydroperoxides including lipid peroxidases, using GSH as a specific electron donor substrate. GSH peroxidase contains one selenocysteine residue per...; Region: GSH_Peroxidase; cd00340 1310161006725 catalytic residues [active] 1310161006726 dimer interface [polypeptide binding]; other site 1310161006727 Predicted extracellular nuclease [General function prediction only]; Region: COG2374 1310161006728 YhcR_OBF_like: A subfamily of OB-fold domains similar to the OB folds of Bacillus subtilis YhcR. YhcR is a sugar-nonspecific nuclease, which is active in the presence of Ca2+ and Mn2+. It cleaves RNA endonucleolytically, producing 3'-monophosphate...; Region: YhcR_OBF_like; cd04486 1310161006729 generic binding surface II; other site 1310161006730 generic binding surface I; other site 1310161006731 Mycoplasma pulmonis MnuA nuclease-like; Region: MnuA_DNase1-like; cd10283 1310161006732 putative active site [active] 1310161006733 putative catalytic site [active] 1310161006734 putative Mg binding site IVb [ion binding]; other site 1310161006735 putative phosphate binding site [ion binding]; other site 1310161006736 putative DNA binding site [nucleotide binding]; other site 1310161006737 putative Mg binding site IVa [ion binding]; other site 1310161006738 Predicted deacetylase [General function prediction only]; Region: COG3233 1310161006739 Putative catalytic domain of uncharacterized bacterial proteins from the carbohydrate esterase 4 superfamily; Region: CE4_u10; cd11374 1310161006740 putative active site [active] 1310161006741 putative Zn binding site [ion binding]; other site 1310161006742 Sodium:dicarboxylate symporter family; Region: SDF; cl00573 1310161006743 Na+/H+-dicarboxylate symporters [Energy production and conversion]; Region: GltP; COG1301 1310161006744 Protease II [Amino acid transport and metabolism]; Region: PtrB; COG1770 1310161006745 Prolyl oligopeptidase family; Region: Peptidase_S9; pfam00326 1310161006746 non-metazoan 5-aminoimidazole-4-(N-succinylcarboxamide) ribonucleotide (SAICAR) synthase; Region: SAICAR_synt_Sc; cd01414 1310161006747 ATP binding site [chemical binding]; other site 1310161006748 active site 1310161006749 substrate binding site [chemical binding]; other site 1310161006750 Adenylosuccinate lyase [Nucleotide transport and metabolism]; Region: PurB; COG0015 1310161006751 Lyase class I_like superfamily: contains the lyase class I family, histidine ammonia-lyase and phenylalanine ammonia-lyase, which catalyze similar beta-elimination reactions; Region: Lyase_I_like; cl00013 1310161006752 tetramer interface [polypeptide binding]; other site 1310161006753 aspartate aminotransferase; Provisional; Region: PRK05764 1310161006754 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 1310161006755 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1310161006756 homodimer interface [polypeptide binding]; other site 1310161006757 catalytic residue [active] 1310161006758 phosphoribosylamine--glycine ligase; Provisional; Region: PRK00885 1310161006759 Phosphoribosylglycinamide synthetase, N domain; Region: GARS_N; pfam02844 1310161006760 Phosphoribosylglycinamide synthetase, ATP-grasp (A) domain; Region: GARS_A; pfam01071 1310161006761 Phosphoribosylglycinamide synthetase, C domain; Region: GARS_C; pfam02843 1310161006762 Diadenosine tetraphosphate (Ap4A) hydrolase and other HIT family hydrolases [Nucleotide transport and metabolism / Carbohydrate transport and metabolism / General function prediction only]; Region: Hit; COG0537 1310161006763 nucleotide binding site/active site [active] 1310161006764 HIT family signature motif; other site 1310161006765 catalytic residue [active] 1310161006766 Methyltransferase domain; Region: Methyltransf_31; pfam13847 1310161006767 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 1310161006768 S-adenosylmethionine binding site [chemical binding]; other site 1310161006769 Dipeptide/tripeptide permease [Amino acid transport and metabolism]; Region: PTR2; COG3104 1310161006770 POT family; Region: PTR2; cl17359 1310161006771 adenosylmethionine--8-amino-7-oxononanoate transaminase; Provisional; Region: PRK05630 1310161006772 Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610 1310161006773 inhibitor-cofactor binding pocket; inhibition site 1310161006774 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1310161006775 catalytic residue [active] 1310161006776 AAA domain; Region: AAA_26; pfam13500 1310161006777 The Fer4_NifH superfamily contains a variety of proteins which share a common ATP-binding domain. Functionally, proteins in this superfamily use the energy from hydrolysis of NTP to transfer electron or ion; Region: Fer4_NifH; cl17203 1310161006778 Dethiobiotin synthetase (DTBS) is the penultimate enzyme in the biotin biosynthesis pathway in Escherichia coli and other microorganisms. The enzyme catalyzes formation of the ureido ring of dethiobiotin from (7R,8S)-7,8-diaminononanoic acid (DAPA) and...; Region: DTBS; cd03109 1310161006779 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 1310161006780 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 1310161006781 dimerization interface [polypeptide binding]; other site 1310161006782 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 1310161006783 dimer interface [polypeptide binding]; other site 1310161006784 phosphorylation site [posttranslational modification] 1310161006785 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1310161006786 ATP binding site [chemical binding]; other site 1310161006787 Mg2+ binding site [ion binding]; other site 1310161006788 G-X-G motif; other site 1310161006789 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 1310161006790 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1310161006791 active site 1310161006792 phosphorylation site [posttranslational modification] 1310161006793 intermolecular recognition site; other site 1310161006794 dimerization interface [polypeptide binding]; other site 1310161006795 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 1310161006796 DNA binding site [nucleotide binding] 1310161006797 Predicted transcriptional regulators [Transcription]; Region: SoxR; COG0789 1310161006798 Helix-Turn-Helix DNA binding domain of the transcription regulators TipAL, Mta, and SkgA; Region: HTH_TipAL-Mta; cd01106 1310161006799 DNA binding residues [nucleotide binding] 1310161006800 dimer interface [polypeptide binding]; other site 1310161006801 TipAS antibiotic-recognition domain; Region: TipAS; pfam07739 1310161006802 Predicted amino acid aldolase or racemase [Amino acid transport and metabolism]; Region: COG3616 1310161006803 Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzymes, Low Specificity D-Threonine Aldolase-like; Region: PLPDE_III_LS_D-TA_like; cd06820 1310161006804 dimer interface [polypeptide binding]; other site 1310161006805 active site 1310161006806 pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site 1310161006807 substrate binding site [chemical binding]; other site 1310161006808 catalytic residue [active] 1310161006809 pyruvate dehydrogenase; Provisional; Region: PRK06546 1310161006810 Pyrimidine (PYR) binding domain of POX; Region: TPP_PYR_POX; cd07039 1310161006811 PYR/PP interface [polypeptide binding]; other site 1310161006812 dimer interface [polypeptide binding]; other site 1310161006813 tetramer interface [polypeptide binding]; other site 1310161006814 TPP binding site [chemical binding]; other site 1310161006815 Thiamine pyrophosphate enzyme, central domain; Region: TPP_enzyme_M; pfam00205 1310161006816 Thiamine pyrophosphate (TPP) family, Pyruvate oxidase (POX) subfamily, TPP-binding module; composed of proteins similar to Lactobacillus plantarum POX, which plays a key role in controlling acetate production under aerobic conditions. POX decarboxylates...; Region: TPP_POX; cd02014 1310161006817 TPP-binding site [chemical binding]; other site 1310161006818 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1310161006819 Major Facilitator Superfamily; Region: MFS_1; pfam07690 1310161006820 putative substrate translocation pore; other site 1310161006821 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1310161006822 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 1310161006823 Permeases of the major facilitator superfamily [General function prediction only]; Region: COG2270 1310161006824 Ion channel regulatory protein UNC-93; Region: UNC-93; pfam05978 1310161006825 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1310161006826 glycosyl hydrolase family 16; Region: Glyco_hydrolase_16; cl00218 1310161006827 active site 1310161006828 catalytic residues [active] 1310161006829 glycosyl hydrolase family 16; Region: Glyco_hydrolase_16; cl00218 1310161006830 active site 1310161006831 catalytic residues [active] 1310161006832 putative FAD-binding dehydrogenase; Reviewed; Region: PRK12843 1310161006833 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 1310161006834 The C-terminal substrate binding domain of LysR-type transcriptional regulators involved in the catabolism of aromatic compounds and that of other related regulators, contains type 2 periplasmic binding fold; Region: PBP2_LTTR_aromatics_like; cd08414 1310161006835 dimerization interface [polypeptide binding]; other site 1310161006836 substrate binding pocket [chemical binding]; other site 1310161006837 diaminopimelate dehydrogenase; Region: DAP-DH; TIGR01921 1310161006838 Glyceraldehyde 3-phosphate dehydrogenase, NAD binding domain; Region: Gp_dh_N; cl17742 1310161006839 Phospholipase/Carboxylesterase; Region: Abhydrolase_2; pfam02230 1310161006840 Cof subfamily of IIB subfamily of haloacid dehalogenase superfamily; Region: Cof-subfamily; TIGR00099 1310161006841 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 1310161006842 active site 1310161006843 motif I; other site 1310161006844 motif II; other site 1310161006845 haloacid dehalogenase-like hydrolase; Region: HAD; cl17202 1310161006846 Uncharacterized conserved protein [Function unknown]; Region: COG5646 1310161006847 Helix-turn-helix XRE-family like proteins; Region: HTH_XRE; smart00530 1310161006848 non-specific DNA binding site [nucleotide binding]; other site 1310161006849 salt bridge; other site 1310161006850 sequence-specific DNA binding site [nucleotide binding]; other site 1310161006851 Uncharacterized conserved protein [Function unknown]; Region: COG2966 1310161006852 Protein of unknown function (DUF1212); Region: DUF1212; pfam06738 1310161006853 Uncharacterized conserved protein [Function unknown]; Region: COG3610 1310161006854 Trehalose-6-phosphate synthase [Carbohydrate transport and metabolism]; Region: OtsA; COG0380 1310161006855 Trehalose-6-Phosphate Synthase (TPS) is a glycosyltransferase that catalyses the synthesis of alpha,alpha-1,1-trehalose-6-phosphate from glucose-6-phosphate using a UDP-glucose donor. It is a key enzyme in the trehalose synthesis pathway. Trehalose is a...; Region: GT1_TPS; cd03788 1310161006856 active site 1310161006857 homotetramer interface [polypeptide binding]; other site 1310161006858 META domain; Region: META; cl01245 1310161006859 Trehalose-6-phosphatase [Carbohydrate transport and metabolism]; Region: OtsB; COG1877 1310161006860 trehalose-6-phosphate phosphatase; Provisional; Region: PRK10187; cl17105 1310161006861 Transcriptional regulators [Transcription]; Region: PurR; COG1609 1310161006862 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 1310161006863 DNA binding site [nucleotide binding] 1310161006864 domain linker motif; other site 1310161006865 Ligand-binding domain of uncharacterized DNA-binding regulatory proteins that are members of the LacI-GalR family of bacterial transcription repressors; Region: PBP1_LacI_like_3; cd06279 1310161006866 putative dimerization interface [polypeptide binding]; other site 1310161006867 putative ligand binding site [chemical binding]; other site 1310161006868 ABC-type metal ion transport system, periplasmic component/surface adhesin [Inorganic ion transport and metabolism]; Region: LraI; COG0803 1310161006869 Helical backbone metal receptor (TroA-like domain). These proteins have been shown to function in the ABC transport of ferric siderophores and metal ions such as Mn2+, Fe3+, Cu2+ and/or Zn2+. Their ligand binding site is formed in the interface between...; Region: TroA-like; cl00262 1310161006870 intersubunit interface [polypeptide binding]; other site 1310161006871 ABC-type Mn/Zn transport systems, ATPase component [Inorganic ion transport and metabolism]; Region: ZnuC; COG1121 1310161006872 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 1310161006873 Walker A/P-loop; other site 1310161006874 ATP binding site [chemical binding]; other site 1310161006875 Q-loop/lid; other site 1310161006876 ABC transporter signature motif; other site 1310161006877 Walker B; other site 1310161006878 D-loop; other site 1310161006879 H-loop/switch region; other site 1310161006880 ABC-type Mn2+/Zn2+ transport systems, permease components [Inorganic ion transport and metabolism]; Region: ZnuB; COG1108 1310161006881 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550 1310161006882 dimer interface [polypeptide binding]; other site 1310161006883 putative PBP binding regions; other site 1310161006884 ABC-ATPase subunit interface; other site 1310161006885 Winged helix-turn helix; Region: HTH_29; pfam13551 1310161006886 Helix-turn-helix domain; Region: HTH_28; pfam13518 1310161006887 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: Tra5; COG2801 1310161006888 Integrase core domain; Region: rve; pfam00665 1310161006889 Integrase core domain; Region: rve_3; pfam13683 1310161006890 hypothetical protein; Provisional; Region: PRK12839 1310161006891 Xylose isomerase-like TIM barrel; Region: AP_endonuc_2; pfam01261 1310161006892 Oxidoreductase family, C-terminal alpha/beta domain; Region: GFO_IDH_MocA_C; pfam02894 1310161006893 Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673 1310161006894 Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673 1310161006895 Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408 1310161006896 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1310161006897 putative substrate translocation pore; other site 1310161006898 metabolite-proton symporter; Region: 2A0106; TIGR00883 1310161006899 Transcriptional regulator [Transcription]; Region: IclR; COG1414 1310161006900 Bacterial transcriptional regulator; Region: IclR; pfam01614 1310161006901 rRNA methylases [Translation, ribosomal structure and biogenesis]; Region: SpoU; COG0566 1310161006902 RNA 2'-O ribose methyltransferase substrate binding; Region: SpoU_sub_bind; pfam08032 1310161006903 SpoU rRNA Methylase family; Region: SpoU_methylase; pfam00588 1310161006904 cysteinyl-tRNA synthetase; Validated; Region: cysS; PRK00260 1310161006905 nucleotidyl transferase superfamily; Region: nt_trans; cl00015 1310161006906 active site 1310161006907 HIGH motif; other site 1310161006908 nucleotide binding site [chemical binding]; other site 1310161006909 catalytic core domain of cysteinyl tRNA synthetase; Region: CysRS_core; cd00672 1310161006910 KMSKS motif; other site 1310161006911 Anticodon-binding domain of class Ia aminoacyl tRNA synthetases and similar domains; Region: Anticodon_Ia_like; cl12020 1310161006912 PTS system, sucrose-specific IIBC component; Region: PTS-II-BC-sucr; TIGR01996 1310161006913 PTS_IIB, PTS system, glucose/sucrose specific IIB subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIB_glc; cd00212 1310161006914 active site turn [active] 1310161006915 phosphorylation site [posttranslational modification] 1310161006916 Phosphotransferase system IIC components, glucose/maltose/N-acetylglucosamine-specific [Carbohydrate transport and metabolism]; Region: PtsG; COG1263 1310161006917 Phosphotransferase system IIA components [Carbohydrate transport and metabolism]; Region: NagE; COG2190 1310161006918 HPr interaction site; other site 1310161006919 glycerol kinase (GK) interaction site [polypeptide binding]; other site 1310161006920 active site 1310161006921 phosphorylation site [posttranslational modification] 1310161006922 6-phosphogluconolactonase/Glucosamine-6-phosphate isomerase/deaminase [Carbohydrate transport and metabolism]; Region: NagB; COG0363 1310161006923 GlcN6P_deaminase: Glucosamine-6-phosphate (GlcN6P) deaminase subfamily; GlcN6P deaminase catalyzes the reversible conversion of GlcN6P to D-fructose-6-phosphate (Fru6P) and ammonium. The reaction is an aldo-keto isomerization coupled with an amination or...; Region: GlcN6P_deaminase; cd01399 1310161006924 active site 1310161006925 trimer interface [polypeptide binding]; other site 1310161006926 allosteric site; other site 1310161006927 active site lid [active] 1310161006928 hexamer (dimer of trimers) interface [polypeptide binding]; other site 1310161006929 N-acetylglucosamine-6-phosphate deacetylase [Carbohydrate transport and metabolism]; Region: NagA; COG1820 1310161006930 N-acetylglucosamine-6-phosphate deacetylase, NagA, catalyzes the hydrolysis of the N-acetyl group of N-acetyl-glucosamine-6-phosphate (GlcNAc-6-P) to glucosamine 6-phosphate and acetate. This is the first committed step in the biosynthetic pathway to...; Region: NagA; cd00854 1310161006931 active site 1310161006932 dimer interface [polypeptide binding]; other site 1310161006933 Dihydrodipicolinate synthase/N-acetylneuraminate lyase [Amino acid transport and metabolism / Cell envelope biogenesis, outer membrane]; Region: DapA; COG0329 1310161006934 Dihydrodipicolinate synthase family; Region: DHDPS-like; cd00408 1310161006935 inhibitor site; inhibition site 1310161006936 active site 1310161006937 dimer interface [polypeptide binding]; other site 1310161006938 catalytic residue [active] 1310161006939 ROK family protein (putative glucokinase); Region: ROK_glcA_fam; TIGR00744 1310161006940 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cd00012 1310161006941 nucleotide binding site [chemical binding]; other site 1310161006942 Putative N-acetylmannosamine-6-phosphate epimerase [Carbohydrate transport and metabolism]; Region: NanE; COG3010 1310161006943 N-acetylmannosamine-6-phosphate epimerase (NanE) converts N-acetylmannosamine-6-phosphate to N-acetylglucosamine-6-phosphate. This reaction is part of the pathway that allows the usage of sialic acid as a carbohydrate source. Sialic acids are a family of...; Region: NanE; cd04729 1310161006944 putative active site cavity [active] 1310161006945 Sialidases or neuraminidases function to bind and hydrolyze terminal sialic acid residues from various glycoconjugates as well as playing roles in pathogenesis, bacterial nutrition and cellular interactions. They have a six-bladed, beta-propeller fold...; Region: Sialidase; cd00260 1310161006946 catalytic site [active] 1310161006947 Asp-box motif; other site 1310161006948 Transcriptional regulators [Transcription]; Region: FadR; COG2186 1310161006949 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 1310161006950 DNA-binding site [nucleotide binding]; DNA binding site 1310161006951 FCD domain; Region: FCD; pfam07729 1310161006952 ABC-type dipeptide transport system, periplasmic component [Amino acid transport and metabolism]; Region: DdpA; COG0747 1310161006953 The substrate-binding domain of an ABC-type nickel/oligopeptide-like import system contains the type 2 periplasmic binding fold; Region: PBP2_NikA_DppA_OppA_like; cd00995 1310161006954 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppB; COG0601 1310161006955 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1310161006956 dimer interface [polypeptide binding]; other site 1310161006957 conserved gate region; other site 1310161006958 putative PBP binding loops; other site 1310161006959 ABC-ATPase subunit interface; other site 1310161006960 nickel ABC transporter, permease subunit NikC; Region: nickel_nikC; TIGR02790 1310161006961 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1310161006962 dimer interface [polypeptide binding]; other site 1310161006963 conserved gate region; other site 1310161006964 putative PBP binding loops; other site 1310161006965 ABC-ATPase subunit interface; other site 1310161006966 ABC-type dipeptide/oligopeptide/nickel transport system, ATPase component [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppD; COG0444 1310161006967 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 1310161006968 Walker A/P-loop; other site 1310161006969 ATP binding site [chemical binding]; other site 1310161006970 Q-loop/lid; other site 1310161006971 ABC transporter signature motif; other site 1310161006972 Walker B; other site 1310161006973 D-loop; other site 1310161006974 H-loop/switch region; other site 1310161006975 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; pfam08352 1310161006976 ABC-type dipeptide/oligopeptide/nickel transport system, ATPase component [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppF; COG1124 1310161006977 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 1310161006978 Walker A/P-loop; other site 1310161006979 ATP binding site [chemical binding]; other site 1310161006980 Q-loop/lid; other site 1310161006981 ABC transporter signature motif; other site 1310161006982 Walker B; other site 1310161006983 D-loop; other site 1310161006984 H-loop/switch region; other site 1310161006985 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097 1310161006986 Putative threonine efflux protein [Amino acid transport and metabolism]; Region: RhtB; COG1280 1310161006987 Transcriptional regulators [Transcription]; Region: Lrp; COG1522 1310161006988 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 1310161006989 putative DNA binding site [nucleotide binding]; other site 1310161006990 putative Zn2+ binding site [ion binding]; other site 1310161006991 AsnC family; Region: AsnC_trans_reg; pfam01037 1310161006992 MECDP_synthase (2-C-methyl-D-erythritol-2,4-cyclodiphosphate synthase), encoded by the ispF gene, catalyzes the formation of 2-C-methyl-D-erythritol 2,4-cyclodiphosphate (MEC) in the non-mevalonate deoxyxylulose (DOXP) pathway for isoprenoid biosynthesis; Region: MECDP_synthase; cd00554 1310161006993 homotrimer interaction site [polypeptide binding]; other site 1310161006994 zinc binding site [ion binding]; other site 1310161006995 CDP-binding sites; other site 1310161006996 CDP-ME synthetase is involved in mevalonate-independent isoprenoid production; Region: CDP-ME_synthetase; cd02516 1310161006997 substrate binding site; other site 1310161006998 dimer interface; other site 1310161006999 Transcriptional regulators, similar to M. xanthus CarD [Transcription]; Region: COG1329 1310161007000 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 1310161007001 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1310161007002 active site 1310161007003 phosphorylation site [posttranslational modification] 1310161007004 intermolecular recognition site; other site 1310161007005 dimerization interface [polypeptide binding]; other site 1310161007006 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 1310161007007 DNA binding site [nucleotide binding] 1310161007008 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 1310161007009 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 1310161007010 dimerization interface [polypeptide binding]; other site 1310161007011 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 1310161007012 dimer interface [polypeptide binding]; other site 1310161007013 phosphorylation site [posttranslational modification] 1310161007014 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1310161007015 ATP binding site [chemical binding]; other site 1310161007016 Mg2+ binding site [ion binding]; other site 1310161007017 G-X-G motif; other site 1310161007018 DNA repair protein RadA; Provisional; Region: PRK11823 1310161007019 RecA-like NTPases. This family includes the NTP binding domain of F1 and V1 H+ATPases, DnaB and related helicases as well as bacterial RecA and related eukaryotic and archaeal recombinases. This group also includes bacterial conjugation proteins and...; Region: RecA-like_NTPases; cl17233 1310161007020 Walker A motif; other site 1310161007021 ATP binding site [chemical binding]; other site 1310161007022 Walker B motif; other site 1310161007023 Subunit ChlI of Mg-chelatase; Region: ChlI; pfam13541 1310161007024 Predicted nucleic-acid-binding protein (contains the HHH domain) [General function prediction only]; Region: COG1623 1310161007025 DisA bacterial checkpoint controller nucleotide-binding; Region: DisA_N; pfam02457 1310161007026 DisA bacterial checkpoint controller linker region; Region: DisA-linker; pfam10635 1310161007027 NADP+-dependent p-hydroxybenzaldehyde dehydrogenase-like; Region: ALDH_HBenzADH; cd07151 1310161007028 Aldehyde dehydrogenase family; Region: Aldedh; pfam00171 1310161007029 NAD(P) binding site [chemical binding]; other site 1310161007030 catalytic residues [active] 1310161007031 Carbonic anhydrases (CA) are zinc-containing enzymes that catalyze the reversible hydration of carbon dioxide in a two-step mechanism in which the nucleophilic attack of a zinc-bound hydroxide ion on carbon dioxide is followed by the regeneration of an...; Region: beta_CA_cladeC; cd03378 1310161007032 active site clefts [active] 1310161007033 zinc binding site [ion binding]; other site 1310161007034 dimer interface [polypeptide binding]; other site 1310161007035 endonuclease III; includes endonuclease III (DNA-(apurinic or apyrimidinic site) lyase), alkylbase DNA glycosidases (Alka-family) and other DNA glycosidases; Region: ENDO3c; cd00056 1310161007036 endonuclease III; Region: ENDO3c; smart00478 1310161007037 minor groove reading motif; other site 1310161007038 helix-hairpin-helix signature motif; other site 1310161007039 substrate binding pocket [chemical binding]; other site 1310161007040 active site 1310161007041 iron-sulpphur binding domain in DNA-(apurinic or apyrimidinic site) lyase (subfamily of ENDO3); Region: FES; smart00525 1310161007042 Mono-functional DNA-alkylating methyl methanesulfonate N-term; Region: MMS1_N; pfam10433 1310161007043 meso-2,3-butanediol dehydrogenase-like, classical (c) SDRs; Region: meso-BDH-like_SDR_c; cd05366 1310161007044 acetoin reductases; Region: 23BDH; TIGR02415 1310161007045 NAD binding site [chemical binding]; other site 1310161007046 homotetramer interface [polypeptide binding]; other site 1310161007047 homodimer interface [polypeptide binding]; other site 1310161007048 active site 1310161007049 substrate binding site [chemical binding]; other site 1310161007050 Uncharacterized enzyme involved in biosynthesis of extracellular polysaccharides [General function prediction only]; Region: COG2329 1310161007051 ATP-binding subunits of Clp protease and DnaK/DnaJ chaperones [Posttranslational modification, protein turnover, chaperones]; Region: clpA; COG0542 1310161007052 Clp amino terminal domain; Region: Clp_N; pfam02861 1310161007053 Clp amino terminal domain; Region: Clp_N; pfam02861 1310161007054 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 1310161007055 Walker A motif; other site 1310161007056 ATP binding site [chemical binding]; other site 1310161007057 Walker B motif; other site 1310161007058 arginine finger; other site 1310161007059 UvrB/uvrC motif; Region: UVR; pfam02151 1310161007060 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 1310161007061 Walker A motif; other site 1310161007062 ATP binding site [chemical binding]; other site 1310161007063 Walker B motif; other site 1310161007064 C-terminal, D2-small domain, of ClpB protein; Region: ClpB_D2-small; pfam10431 1310161007065 inosine 5-monophosphate dehydrogenase; Validated; Region: PRK07807 1310161007066 IMP dehydrogenase/GMP reductase [Nucleotide transport and metabolism]; Region: GuaB; COG0516 1310161007067 The CBS domain, named after human CBS, is a small domain originally identified in cystathionine beta-synthase and is subsequently found in a wide range of different proteins. CBS domains usually occur in tandem repeats. They associate to form a so-called...; Region: CBS_pair; cd02205 1310161007068 IMPDH: The catalytic domain of the inosine monophosphate dehydrogenase. IMPDH catalyzes the NAD-dependent oxidation of inosine 5'-monophosphate (IMP) to xanthosine 5' monophosphate (XMP). It is a rate-limiting step in the de novo synthesis of...; Region: IMPDH; cd00381 1310161007069 active site 1310161007070 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 1310161007071 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 1310161007072 phenol 2-monooxygenase; Provisional; Region: PRK08294 1310161007073 FAD-dependent Phenol hydoxylase (PHOX) family, C-terminal TRX-fold domain; composed of proteins similar to PHOX from the aerobic topsoil yeast Trichosporon cutaneum. PHOX is a flavoprotein monooxygenase that catalyzes the hydroxylation of phenol and...; Region: PHOX_C; cd02979 1310161007074 dimer interface [polypeptide binding]; other site 1310161007075 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1310161007076 putative substrate translocation pore; other site 1310161007077 lysyl-tRNA synthetase; Reviewed; Region: lysS; PRK00484 1310161007078 LysRS_N: N-terminal, anticodon recognition domain of lysyl-tRNA synthetases (LysRS). These enzymes are homodimeric class 2b aminoacyl-tRNA synthetases (aaRSs). This domain is a beta-barrel domain (OB fold) involved in binding the tRNA anticodon stem-loop; Region: LysRS_N; cd04322 1310161007079 dimer interface [polypeptide binding]; other site 1310161007080 putative anticodon binding site; other site 1310161007081 Class II tRNA amino-acyl synthetase-like catalytic core domain. Class II amino acyl-tRNA synthetases (aaRS) share a common fold and generally attach an amino acid to the 3' OH of ribose of the appropriate tRNA. PheRS is an exception in that it...; Region: class_II_aaRS-like_core; cl00268 1310161007082 motif 1; other site 1310161007083 dimer interface [polypeptide binding]; other site 1310161007084 active site 1310161007085 motif 2; other site 1310161007086 motif 3; other site 1310161007087 Panthothenate synthetase [Coenzyme metabolism]; Region: PanC; COG0414 1310161007088 pantoate--beta-alanine ligase; Region: panC; TIGR00018 1310161007089 active site 1310161007090 nucleotide binding site [chemical binding]; other site 1310161007091 HIGH motif; other site 1310161007092 KMSKS motif; other site 1310161007093 Rossmann-like domain; Region: Rossmann-like; pfam10727 1310161007094 Domain of unknown function (DUF2520); Region: DUF2520; pfam10728 1310161007095 Protein of unknown function (DUF3180); Region: DUF3180; pfam11377 1310161007096 7,8-dihydro-6-hydroxymethylpterin-pyrophosphokinase (HPPK). Folate derivatives are essential cofactors in the biosynthesis of purines, pyrimidines, and amino acids as well as formyl-tRNA. Mammalian cells are able to utilize pre-formed folates after...; Region: HPPK; cd00483 1310161007097 catalytic center binding site [active] 1310161007098 ATP binding site [chemical binding]; other site 1310161007099 Dihydroneopterin aldolase (DHNA) and 7,8-dihydroneopterin triphosphate epimerase domain (DHNTPE); these enzymes have been designated folB and folX, respectively. Folate derivatives are essential cofactors in the biosynthesis of purines, pyrimidines, and...; Region: DHNA_DHNTPE; cd00534 1310161007100 homooctamer interface [polypeptide binding]; other site 1310161007101 active site 1310161007102 DHPS subgroup of Pterin binding enzymes. DHPS (dihydropteroate synthase), a functional homodimer, catalyzes the condensation of p-aminobenzoic acid (pABA) in the de novo biosynthesis of folate, which is an essential cofactor in both nucleic acid and...; Region: DHPS; cd00739 1310161007103 dihydropteroate synthase; Region: DHPS; TIGR01496 1310161007104 substrate binding pocket [chemical binding]; other site 1310161007105 dimer interface [polypeptide binding]; other site 1310161007106 inhibitor binding site; inhibition site 1310161007107 GTP cyclohydrolase I; Provisional; Region: PLN03044 1310161007108 GTP cyclohydrolase I (GTP-CH-I) catalyzes the conversion of GTP into dihydroneopterin triphosphate. The enzyme product is the precursor of tetrahydrofolate in eubacteria, fungi, and plants and of the folate analogs in methanogenic bacteria. In...; Region: GTP_cyclohydro1; cd00642 1310161007109 homodecamer interface [polypeptide binding]; other site 1310161007110 active site 1310161007111 putative catalytic site residues [active] 1310161007112 zinc binding site [ion binding]; other site 1310161007113 GTP-CH-I/GFRP interaction surface; other site 1310161007114 ATP-dependent metalloprotease FtsH; Region: FtsH_fam; TIGR01241 1310161007115 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 1310161007116 Walker A motif; other site 1310161007117 ATP binding site [chemical binding]; other site 1310161007118 Walker B motif; other site 1310161007119 arginine finger; other site 1310161007120 Peptidase family M41; Region: Peptidase_M41; pfam01434 1310161007121 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 1310161007122 active site 1310161007123 tRNA(Ile)-lysidine synthase MesJ [Cell cycle control, cell division, chromosome partitioning]; Region: MesJ; COG0037 1310161007124 N-terminal domain of predicted ATPase of the PP-loop faimly implicated in cell cycle control [Cell division and chromosome partitioning]. This is a subfamily of Adenine nucleotide alpha hydrolases superfamily.Adeninosine nucleotide alpha hydrolases...; Region: PP-ATPase; cd01992 1310161007125 Ligand Binding Site [chemical binding]; other site 1310161007126 D-alanyl-D-alanine carboxypeptidase (penicillin-binding protein 4) [Cell envelope biogenesis, outer membrane]; Region: DacB; COG2027 1310161007127 D-alanyl-D-alanine carboxypeptidase, serine-type, PBP4 family; Region: PBP4; TIGR00666 1310161007128 Inorganic pyrophosphatase. These enzymes hydrolyze inorganic pyrophosphate (PPi) to two molecules of orthophosphates (Pi). The reaction requires bivalent cations. The enzymes in general exist as homooligomers; Region: pyrophosphatase; cd00412 1310161007129 dimer interface [polypeptide binding]; other site 1310161007130 substrate binding site [chemical binding]; other site 1310161007131 metal binding sites [ion binding]; metal-binding site 1310161007132 Predicted spermidine synthase with an N-terminal membrane domain [General function prediction only]; Region: COG4262 1310161007133 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 1310161007134 S-adenosylmethionine binding site [chemical binding]; other site 1310161007135 Predicted membrane protein [Function unknown]; Region: COG3766 1310161007136 Domain of Unknown Function (DUF350); Region: DUF350; pfam03994 1310161007137 Domain of unknown function (DUF4247); Region: DUF4247; pfam14042 1310161007138 Protein of unknown function DUF2617; Region: DUF2617; pfam10936 1310161007139 Domain of unknown function (DUF4178); Region: DUF4178; pfam13785 1310161007142 phenylpropionate dioxygenase ferredoxin reductase subunit; Provisional; Region: PRK09754 1310161007143 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500 1310161007144 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 1310161007145 Rhodanese Homology Domain (RHOD); an alpha beta fold domain found duplicated in the rhodanese protein. The cysteine containing enzymatically active version of the domain is also found in the Cdc25 class of protein phosphatases and a variety of proteins...; Region: RHOD; cd00158 1310161007146 active site residue [active] 1310161007147 Transcriptional regulators [Transcription]; Region: MarR; COG1846 1310161007148 MarR family; Region: MarR_2; pfam12802 1310161007149 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 1310161007150 amino acid adenylation domain; Region: AA-adenyl-dom; TIGR01733 1310161007151 acyl-activating enzyme (AAE) consensus motif; other site 1310161007152 AMP binding site [chemical binding]; other site 1310161007153 active site 1310161007154 CoA binding site [chemical binding]; other site 1310161007155 Phosphopantetheine attachment site; Region: PP-binding; pfam00550 1310161007156 non-ribosomal peptide synthetase terminal domain of unknown function; Region: NRPS_term_dom; TIGR02353 1310161007157 Left-handed parallel beta-Helix (LbetaH or LbH) domain: The alignment contains 5 turns, each containing three imperfect tandem repeats of a hexapeptide repeat motif (X-[STAV]-X-[LIV]-[GAED]-X). Proteins containing hexapeptide repeats are often enzymes...; Region: LbetaH; cl00160 1310161007158 putative CoA binding site [chemical binding]; other site 1310161007159 putative trimer interface [polypeptide binding]; other site 1310161007160 Protein of unknown function (DUF3754); Region: DUF3754; pfam12576 1310161007161 Left-handed parallel beta-Helix (LbetaH or LbH) domain: The alignment contains 5 turns, each containing three imperfect tandem repeats of a hexapeptide repeat motif (X-[STAV]-X-[LIV]-[GAED]-X). Proteins containing hexapeptide repeats are often enzymes...; Region: LbetaH; cl00160 1310161007162 putative trimer interface [polypeptide binding]; other site 1310161007163 putative CoA binding site [chemical binding]; other site 1310161007164 succinic semialdehyde dehydrogenase; Reviewed; Region: gabD2; PRK09407 1310161007165 Mycobacterium tuberculosis succinate-semialdehyde dehydrogenase 2-like; Region: ALDH_SSADH2_GabD2; cd07101 1310161007166 NAD(P) binding site [chemical binding]; other site 1310161007167 catalytic residues [active] 1310161007168 polyphosphate kinase 2, PA0141 family; Region: PPK2_P_aer; TIGR03707 1310161007169 chaperonin GroEL; Reviewed; Region: groEL; PRK12849 1310161007170 GroEL_like type I chaperonin. Chaperonins are involved in productive folding of proteins. They share a common general morphology, a double toroid of 2 stacked rings, each composed of 7-9 subunits. The symmetry of type I is seven-fold and they are found...; Region: GroEL; cd03344 1310161007171 ring oligomerisation interface [polypeptide binding]; other site 1310161007172 ATP/Mg binding site [chemical binding]; other site 1310161007173 stacking interactions; other site 1310161007174 hinge regions; other site 1310161007175 Tubulin like; Region: Tubulin_2; pfam13809 1310161007176 von Willebrand factor (vWF) type A domain; Region: VWA; smart00327 1310161007177 metal ion-dependent adhesion site (MIDAS); other site 1310161007178 hypothetical protein; Provisional; Region: PRK07907 1310161007179 M20 Dipeptidases; Region: M20_Dipept_like; cd03893 1310161007180 active site 1310161007181 metal binding site [ion binding]; metal-binding site 1310161007182 dimer interface [polypeptide binding]; other site 1310161007183 acetyl-CoA acetyltransferase; Validated; Region: PRK08242 1310161007184 putative monovalent cation/H+ antiporter subunit A; Reviewed; Region: PRK12644 1310161007185 NADH-Ubiquinone/plastoquinone (complex I), various chains; Region: Oxidored_q1; pfam00361 1310161007186 Multisubunit Na+/H+ antiporter, MnhB subunit [Inorganic ion transport and metabolism]; Region: MnhB; COG2111 1310161007187 Domain of unknown function (DUF4040); Region: DUF4040; cl00676 1310161007188 putative monovalent cation/H+ antiporter subunit C; Reviewed; Region: PRK07946 1310161007189 putative monovalent cation/H+ antiporter subunit D; Reviewed; Region: PRK12665 1310161007190 NADH-Ubiquinone/plastoquinone (complex I), various chains; Region: Oxidored_q1; pfam00361 1310161007191 putative monovalent cation/H+ antiporter subunit E; Reviewed; Region: PRK08965 1310161007192 putative monovalent cation/H+ antiporter subunit F; Reviewed; Region: PRK07948 1310161007193 putative monovalent cation/H+ antiporter subunit G; Reviewed; Region: PRK12592 1310161007194 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 1310161007195 carboxylate-amine ligase; Provisional; Region: PRK13517 1310161007196 carboxylate-amine ligase, YbdK family; Region: gshA_cyan_rel; TIGR02050 1310161007197 LytR cell envelope-related transcriptional attenuator; Region: LytR_C; pfam13399 1310161007198 Protein of unknown function (DUF3263); Region: DUF3263; pfam11662 1310161007199 Polypeptide or peptide deformylase; a family of metalloenzymes that catalyzes the removal of the N-terminal formyl group in a growing polypeptide chain following translation initiation during protein synthesis in prokaryotes. These enzymes utilize Fe(II)...; Region: Pep_deformylase; cd00487 1310161007200 active site 1310161007201 catalytic residues [active] 1310161007202 metal binding site [ion binding]; metal-binding site 1310161007203 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 1310161007204 Coenzyme A binding pocket [chemical binding]; other site 1310161007205 Escherichia coli exonuclease III (ExoIII) and Neisseria meningitides NExo-like subfamily of the ExoIII family purinic/apyrimidinic (AP) endonucleases; Region: ExoIII-like_AP-endo; cd09086 1310161007206 putative catalytic site [active] 1310161007207 putative phosphate binding site [ion binding]; other site 1310161007208 active site 1310161007209 metal binding site A [ion binding]; metal-binding site 1310161007210 DNA binding site [nucleotide binding] 1310161007211 putative AP binding site [nucleotide binding]; other site 1310161007212 putative metal binding site B [ion binding]; other site 1310161007213 cardiolipin synthetase; Reviewed; Region: cls; PRK01642 1310161007214 Catalytic domain of phospholipase D superfamily proteins; Region: PLDc_SF; cl15239 1310161007215 putative active site [active] 1310161007216 catalytic site [active] 1310161007217 Catalytic domain of phospholipase D superfamily proteins; Region: PLDc_SF; cl15239 1310161007218 putative active site [active] 1310161007219 catalytic site [active] 1310161007220 bicyclomycin/multidrug efflux system; Provisional; Region: PRK11102 1310161007221 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1310161007222 putative substrate translocation pore; other site 1310161007223 Na+/phosphate symporter [Inorganic ion transport and metabolism]; Region: NptA; COG1283 1310161007224 Na+/Pi-cotransporter; Region: Na_Pi_cotrans; pfam02690 1310161007225 Na+/Pi-cotransporter; Region: Na_Pi_cotrans; pfam02690 1310161007226 Predicted epimerase, PhzC/PhzF homolog [General function prediction only]; Region: COG0384 1310161007227 ABC-2 family transporter protein; Region: ABC2_membrane_2; cl17866 1310161007228 ABC-2 family transporter protein; Region: ABC2_membrane_4; pfam12730 1310161007229 ABC-type multidrug transport system, ATPase component [Defense mechanisms]; Region: CcmA; COG1131 1310161007230 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 1310161007231 Walker A/P-loop; other site 1310161007232 ATP binding site [chemical binding]; other site 1310161007233 Q-loop/lid; other site 1310161007234 ABC transporter signature motif; other site 1310161007235 Walker B; other site 1310161007236 D-loop; other site 1310161007237 H-loop/switch region; other site 1310161007238 Nudix hydrolase is a superfamily of enzymes found in all three kingdoms of life, and it catalyzes the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+...; Region: Nudix_Hydrolase; cd02883 1310161007239 nudix motif; other site 1310161007240 Bacterial extracellular solute-binding proteins, family 3; Region: SBP_bac_3; pfam00497 1310161007241 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 1310161007242 substrate binding pocket [chemical binding]; other site 1310161007243 membrane-bound complex binding site; other site 1310161007244 hinge residues; other site 1310161007245 Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220 1310161007246 Catalytic domain of Protein Kinases; Region: PKc; cd00180 1310161007247 active site 1310161007248 ATP binding site [chemical binding]; other site 1310161007249 substrate binding site [chemical binding]; other site 1310161007250 activation loop (A-loop); other site 1310161007251 propionate/acetate kinase; Provisional; Region: PRK12379 1310161007252 acetate kinase A/propionate kinase 2; Reviewed; Region: PRK00180 1310161007253 phosphotransacetylase; Reviewed; Region: eutD; PRK09653 1310161007254 ferredoxin-NADP+ reductase; Region: PLN02852 1310161007255 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500 1310161007256 Predicted acyltransferase [General function prediction only]; Region: ElaA; COG2153 1310161007257 phosphoribosylglycinamide formyltransferase 2; Validated; Region: purT; PRK09288 1310161007258 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 1310161007259 ATP-grasp domain; Region: ATP-grasp; pfam02222 1310161007260 putative transposase OrfB; Reviewed; Region: PHA02517 1310161007261 HTH-like domain; Region: HTH_21; pfam13276 1310161007262 Integrase core domain; Region: rve; pfam00665 1310161007263 Integrase core domain; Region: rve_3; pfam13683 1310161007264 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG2963 1310161007265 Transposase; Region: HTH_Tnp_1; pfam01527 1310161007266 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: COG4585 1310161007267 Histidine kinase; Region: HisKA_3; pfam07730 1310161007268 Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase; Region: HATPase_c; pfam02518 1310161007269 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 1310161007270 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1310161007271 active site 1310161007272 phosphorylation site [posttranslational modification] 1310161007273 intermolecular recognition site; other site 1310161007274 dimerization interface [polypeptide binding]; other site 1310161007275 helix_turn_helix, Lux Regulon; Region: HTH_LUXR; smart00421 1310161007276 DNA binding residues [nucleotide binding] 1310161007277 dimerization interface [polypeptide binding]; other site 1310161007278 Adenylosuccinate synthetase; Region: Adenylsucc_synt; smart00788 1310161007279 Adenylosuccinate synthetase (AdSS) catalyzes the first step in the de novo biosynthesis of AMP. IMP and L-aspartate are conjugated in a two-step reaction accompanied by the hydrolysis of GTP to GDP in the presence of Mg2+. In the first step, the...; Region: AdSS; cd03108 1310161007280 GDP-binding site [chemical binding]; other site 1310161007281 ACT binding site; other site 1310161007282 IMP binding site; other site 1310161007283 cardiolipin synthetase; Reviewed; Region: PRK12452 1310161007284 Predicted membrane protein [Function unknown]; Region: COG4129 1310161007285 Fusaric acid resistance protein-like; Region: FUSC_2; pfam13515 1310161007286 fructose-bisphosphate aldolase; Provisional; Region: PRK09197 1310161007287 Class II Type A, Fructose-1,6-bisphosphate (FBP) aldolases. The enzyme catalyses the zinc-dependent, reversible aldol condensation of dihydroxyacetone phosphate with glyceraldehyde-3-phosphate to form fructose-1,6-bisphosphate. FBP aldolase is...; Region: FBP_aldolase_IIA; cd00946 1310161007288 active site 1310161007289 intersubunit interface [polypeptide binding]; other site 1310161007290 zinc binding site [ion binding]; other site 1310161007291 Na+ binding site [ion binding]; other site 1310161007292 Predicted glycosyl hydrolase [Carbohydrate transport and metabolism]; Region: COG4833 1310161007293 rRNA methylases [Translation, ribosomal structure and biogenesis]; Region: SpoU; COG0566 1310161007294 SpoU rRNA Methylase family; Region: SpoU_methylase; cl17307 1310161007295 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 1310161007296 active site 1310161007297 Rhodanese-related sulfurtransferase [Inorganic ion transport and metabolism]; Region: SseA; COG2897 1310161007298 Thiosulfate sulfurtransferase (TST), N-terminal, inactive domain. TST contains 2 copies of the Rhodanese Homology Domain; this is the 1st repeat, which does not contain the catalytically active Cys residue. The role of the 1st repeat is uncertain, but it...; Region: TST_Repeat_1; cd01448 1310161007299 active site residue [active] 1310161007300 Thiosulfate sulfurtransferase (TST), C-terminal, catalytic domain. TST contains 2 copies of the Rhodanese Homology Domain; this is the second repeat. Only the second repeat contains the catalytically active Cys residue; Region: TST_Repeat_2; cd01449 1310161007301 active site residue [active] 1310161007302 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 1310161007303 sequence-specific DNA binding site [nucleotide binding]; other site 1310161007304 salt bridge; other site 1310161007305 H+ Antiporter protein; Region: 2A0121; TIGR00900 1310161007306 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1310161007307 putative substrate translocation pore; other site 1310161007308 Domain of unknown function (DUF4265); Region: DUF4265; pfam14085 1310161007309 ATP-dependent chaperone ClpB; Region: chaperone_ClpB; TIGR03346 1310161007310 Clp amino terminal domain; Region: Clp_N; pfam02861 1310161007311 Clp amino terminal domain; Region: Clp_N; pfam02861 1310161007312 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 1310161007313 Walker A motif; other site 1310161007314 ATP binding site [chemical binding]; other site 1310161007315 Walker B motif; other site 1310161007316 arginine finger; other site 1310161007317 Protein of unknown function (DUF2730); Region: DUF2730; pfam10805 1310161007318 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 1310161007319 Walker A motif; other site 1310161007320 ATP binding site [chemical binding]; other site 1310161007321 Walker B motif; other site 1310161007322 arginine finger; other site 1310161007323 C-terminal, D2-small domain, of ClpB protein; Region: ClpB_D2-small; pfam10431 1310161007324 Na+/glutamate symporter [Amino acid transport and metabolism]; Region: GltS; COG0786 1310161007325 Predicted Co/Zn/Cd cation transporters [Inorganic ion transport and metabolism]; Region: MMT1; COG0053 1310161007326 cation diffusion facilitator family transporter; Region: CDF; TIGR01297 1310161007327 Predicted flavoprotein involved in K+ transport [Inorganic ion transport and metabolism]; Region: TrkA; COG2072 1310161007328 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500 1310161007329 Cystathionine beta-lyases/cystathionine gamma-synthases [Amino acid transport and metabolism]; Region: MetC; COG0626 1310161007330 CGS_like: Cystathionine gamma-synthase is a PLP dependent enzyme and catalyzes the committed step of methionine biosynthesis. This pathway is unique to microorganisms and plants, rendering the enzyme an attractive target for the development of...; Region: CGS_like; cd00614 1310161007331 homodimer interface [polypeptide binding]; other site 1310161007332 substrate-cofactor binding pocket; other site 1310161007333 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1310161007334 catalytic residue [active] 1310161007335 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 1310161007336 non-specific DNA binding site [nucleotide binding]; other site 1310161007337 salt bridge; other site 1310161007338 sequence-specific DNA binding site [nucleotide binding]; other site 1310161007339 Cupin domain; Region: Cupin_2; pfam07883 1310161007342 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4861 1310161007343 Firmicute plasmid replication protein (RepL); Region: RepL; pfam05732 1310161007344 Uncharacterized protein conserved in bacteria (DUF2186); Region: DUF2186; pfam09952 1310161007345 Predicted nucleotidyltransferase [General function prediction only]; Region: COG4849 1310161007346 2-polyprenylphenol hydroxylase and related flavodoxin oxidoreductases [Coenzyme metabolism / Energy production and conversion]; Region: UbiB; COG0543 1310161007347 Ferredoxin reductase (FNR), an FAD and NAD(P) binding protein, was intially identified as a chloroplast reductase activity, catalyzing the electron transfer from reduced iron-sulfur protein ferredoxin to NADP+ as the final step in the electron transport...; Region: FNR_like; cl06868 1310161007348 FAD binding pocket [chemical binding]; other site 1310161007349 conserved FAD binding motif [chemical binding]; other site 1310161007350 phosphate binding motif [ion binding]; other site 1310161007351 beta-alpha-beta structure motif; other site 1310161007352 NAD binding pocket [chemical binding]; other site 1310161007353 Predicted amidohydrolase [General function prediction only]; Region: COG0388 1310161007354 Uncharacterized subgroup of the nitrilase superfamily (putative class 13 nitrilases); Region: nitrilase_3; cd07581 1310161007355 putative active site [active] 1310161007356 catalytic triad [active] 1310161007357 putative dimer interface [polypeptide binding]; other site 1310161007358 Alpha/beta hydrolase; Region: Abhydrolase_8; pfam06259 1310161007359 NAD(P)+-dependent aldehyde dehydrogenase superfamily; Region: ALDH-SF; cl11961 1310161007360 Aldehyde dehydrogenase family; Region: Aldedh; pfam00171 1310161007361 NAD(P) binding site [chemical binding]; other site 1310161007362 catalytic residues [active] 1310161007363 Helix-Turn-Helix DNA binding domain of the HspR transcription regulator; Region: HTH_HspR; cd04766 1310161007364 DNA binding residues [nucleotide binding] 1310161007365 MerR HTH family regulatory protein; Region: MerR_1; pfam13411 1310161007366 putative dimer interface [polypeptide binding]; other site 1310161007367 chaperone protein DnaJ; Provisional; Region: PRK14279 1310161007368 DnaJ domain or J-domain. DnaJ/Hsp40 (heat shock protein 40) proteins are highly conserved and play crucial roles in protein translation, folding, unfolding, translocation, and degradation. They act primarily by stimulating the ATPase activity of Hsp70s; Region: DnaJ; cd06257 1310161007369 HSP70 interaction site [polypeptide binding]; other site 1310161007370 Zinc finger domain of DnaJ and HSP40; Region: DnaJ_zf; cd10719 1310161007371 Zn binding sites [ion binding]; other site 1310161007372 C-terminal substrate binding domain of DnaJ and HSP40; Region: DnaJ_C; cd10747 1310161007373 dimer interface [polypeptide binding]; other site 1310161007374 Molecular chaperone GrpE (heat shock protein) [Posttranslational modification, protein turnover, chaperones]; Region: GrpE; COG0576 1310161007375 GrpE is the adenine nucleotide exchange factor of DnaK (Hsp70)-type ATPases. The GrpE dimer binds to the ATPase domain of Hsp70 catalyzing the dissociation of ADP, which enables rebinding of ATP, one step in the Hsp70 reaction cycle in protein folding; Region: GrpE; cd00446 1310161007376 dimer interface [polypeptide binding]; other site 1310161007377 hsp70 (ATPase domain) interactions [polypeptide binding]; other site 1310161007378 molecular chaperone DnaK; Provisional; Region: dnaK; PRK00290 1310161007379 Nucleotide-binding domain of human HSPA9 and similar proteins; Region: HSPA9-Ssq1-like_NBD; cd10234 1310161007380 nucleotide binding site [chemical binding]; other site 1310161007381 NEF interaction site [polypeptide binding]; other site 1310161007382 SBD interface [polypeptide binding]; other site 1310161007383 nucleosidase; Provisional; Region: PRK05634 1310161007384 Nucleoside phosphorylase [Nucleotide transport and metabolism]; Region: Pfs; COG0775 1310161007385 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4924 1310161007386 Uncharacterized protein conserved in bacteria N-term (DUF3322); Region: DUF3322; pfam11795 1310161007387 Uncharacterized protein conserved in bacteria C-term(DUF2220); Region: DUF2220; pfam09983 1310161007388 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4913 1310161007389 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cd00267 1310161007390 Walker A/P-loop; other site 1310161007391 ATP binding site [chemical binding]; other site 1310161007392 Q-loop/lid; other site 1310161007393 Putative exonuclease SbcCD, C subunit; Region: SbcCD_C; pfam13558 1310161007394 Domain of unknown function (DUF4194); Region: DUF4194; pfam13835 1310161007395 Protein of unknown function (DUF3375); Region: DUF3375; pfam11855 1310161007396 Zn-dependent alcohol dehydrogenases [General function prediction only]; Region: AdhP; COG1064 1310161007397 Cinnamyl alcohol dehydrogenases (CAD); Region: CAD3; cd08297 1310161007398 NAD binding site [chemical binding]; other site 1310161007399 substrate binding site [chemical binding]; other site 1310161007400 catalytic Zn binding site [ion binding]; other site 1310161007401 tetramer interface [polypeptide binding]; other site 1310161007402 structural Zn binding site [ion binding]; other site 1310161007405 Sulfite exporter TauE/SafE; Region: TauE; pfam01925 1310161007406 Sirohydrochlorin ferrochelatase [Inorganic ion transport and metabolism]; Region: COG2138 1310161007407 Sirohydrochlorin cobalt chelatase (CbiX) and sirohydrochlorin iron chelatase (SirB), N-terminal domain. SirB catalyzes the ferro-chelation of sirohydrochlorin to siroheme, the prosthetic group of sulfite and nitrite reductases. CbiX is a cobaltochelatase; Region: CbiX_SirB_N; cd03416 1310161007408 putative active site [active] 1310161007409 Class II Chelatase: a family of ATP-independent monomeric or homodimeric enzymes that catalyze the insertion of metal into protoporphyrin rings. This family includes protoporphyrin IX ferrochelatase (HemH), sirohydrochlorin ferrochelatase (SirB) and the...; Region: Chelatase_Class_II; cl02784 1310161007410 active site 1310161007411 sulfate adenylyltransferase, large subunit; Region: CysN; TIGR02034 1310161007412 CysN, together with protein CysD, forms the ATP sulfurylase (ATPS) complex; Region: CysN_ATPS; cd04166 1310161007413 CysD dimerization site [polypeptide binding]; other site 1310161007414 G1 box; other site 1310161007415 putative GEF interaction site [polypeptide binding]; other site 1310161007416 GTP/Mg2+ binding site [chemical binding]; other site 1310161007417 Switch I region; other site 1310161007418 G2 box; other site 1310161007419 G3 box; other site 1310161007420 Switch II region; other site 1310161007421 G4 box; other site 1310161007422 G5 box; other site 1310161007423 CysN_NodQ_II: This subfamily represents the domain II of the large subunit of ATP sulfurylase (ATPS): CysN or the N-terminal portion of NodQ, found mainly in proteobacteria and homologous to the domain II of EF-Tu. Escherichia coli ATPS consists of CysN...; Region: CysN_NodQ_II; cd03695 1310161007424 Domain III of Elongation factor (EF) Tu (EF-TU) and EF-G. Elongation factors (EF) EF-Tu and EF-G participate in the elongation phase during protein biosynthesis on the ribosome. Their functional cycles depend on GTP binding and its hydrolysis. The EF-Tu...; Region: Translation_factor_III; cl02786 1310161007425 sulfate adenylyltransferase, small subunit; Region: CysD; TIGR02039 1310161007426 This domain is found in phosphoadenosine phosphosulphate (PAPS) reductase enzymes or PAPS sulphotransferase. PAPS reductase is part of the adenine nucleotide alpha hydrolases superfamily also including N type ATP PPases and ATP sulphurylases. A highly...; Region: PAPS_reductase; cd01713 1310161007427 Active Sites [active] 1310161007428 3'-phosphoadenosine 5'-phosphosulfate sulfotransferase (PAPS reductase)/FAD synthetase and related enzymes [Amino acid transport and metabolism / Coenzyme metabolism]; Region: CysH; COG0175 1310161007429 This domain is found in phosphoadenosine phosphosulphate (PAPS) reductase enzymes or PAPS sulphotransferase. PAPS reductase is part of the adenine nucleotide alpha hydrolases superfamily also including N type ATP PPases and ATP sulphurylases. A highly...; Region: PAPS_reductase; cd01713 1310161007430 Active Sites [active] 1310161007431 Sulfite reductase, beta subunit (hemoprotein) [Inorganic ion transport and metabolism]; Region: CysI; COG0155 1310161007432 Nitrite/Sulfite reductase ferredoxin-like half domain; Region: NIR_SIR_ferr; pfam03460 1310161007433 Nitrite/Sulfite reductase ferredoxin-like half domain; Region: NIR_SIR_ferr; pfam03460 1310161007434 ferredoxin-NADP+ reductase; Region: PLN02852 1310161007435 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500 1310161007436 Fic family protein [Function unknown]; Region: COG3177 1310161007437 Fic/DOC family; Region: Fic; pfam02661 1310161007438 Polyphosphate kinase N-terminal domain; Region: PP_kinase_N; pfam13089 1310161007439 Escherichia coli PhnB and similar proteins; the E. coli phnB gene is found next to an operon involved in the cleavage of carbon-phosphorus bonds in unactivated alkylphosphonates; Region: PhnB_like; cd06588 1310161007440 dimer interface [polypeptide binding]; other site 1310161007441 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 1310161007442 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3333 1310161007443 Tripartite tricarboxylate transporter TctB family; Region: TctB; pfam07331 1310161007444 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3181 1310161007445 Predicted ATPase [General function prediction only]; Region: COG3910 1310161007446 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cd00267 1310161007447 Walker A/P-loop; other site 1310161007448 ATP binding site [chemical binding]; other site 1310161007449 Q-loop/lid; other site 1310161007450 ABC transporter signature motif; other site 1310161007451 Walker B; other site 1310161007452 D-loop; other site 1310161007453 H-loop/switch region; other site 1310161007454 Predicted ATPase [General function prediction only]; Region: COG3910 1310161007455 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cd00267 1310161007456 Walker A/P-loop; other site 1310161007457 ATP binding site [chemical binding]; other site 1310161007458 Q-loop/lid; other site 1310161007459 ABC transporter signature motif; other site 1310161007460 Walker B; other site 1310161007461 D-loop; other site 1310161007462 H-loop/switch region; other site 1310161007463 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1310161007464 Major Facilitator Superfamily; Region: MFS_1; pfam07690 1310161007465 putative substrate translocation pore; other site 1310161007466 Acetylornithine deacetylase/Succinyl-diaminopimelate desuccinylase and related deacylases [Amino acid transport and metabolism]; Region: ArgE; COG0624 1310161007467 M20 Peptidase, carboxypeptidase yscS-like; Region: M20_yscS_like; cd05675 1310161007468 putative metal binding site [ion binding]; other site 1310161007469 Thiosulfate reductase cytochrome B subunit (membrane anchoring protein) [Energy production and conversion]; Region: COG4117 1310161007470 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 1310161007471 Walker A/P-loop; other site 1310161007472 ATP binding site [chemical binding]; other site 1310161007473 Q-loop/lid; other site 1310161007474 ABC-type cobalt transport system, ATPase component [Inorganic ion transport and metabolism]; Region: CbiO; COG1122 1310161007475 ABC transporter signature motif; other site 1310161007476 Walker B; other site 1310161007477 D-loop; other site 1310161007478 H-loop/switch region; other site 1310161007479 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cd00267 1310161007480 Walker A/P-loop; other site 1310161007481 ATP binding site [chemical binding]; other site 1310161007482 ABC transporter signature motif; other site 1310161007483 Walker B; other site 1310161007484 D-loop; other site 1310161007485 H-loop/switch region; other site 1310161007486 ABC-type cobalt transport system, permease component CbiQ and related transporters [Inorganic ion transport and metabolism]; Region: CbiQ; COG0619 1310161007487 This family contains NADPH-dependent flavin reductase and oxygen-insensitive nitroreductase. These enzymes are homodimeric flavoproteins that contain one FMN per monomer as a cofactor. Flavin reductase catalyzes the reduction of flavin by using NADPH as...; Region: NfsA_FRP; cd02146 1310161007488 dimer interface [polypeptide binding]; other site 1310161007489 FMN binding site [chemical binding]; other site 1310161007490 NADPH bind site [chemical binding]; other site 1310161007491 Inosine-uridine nucleoside N-ribohydrolase [Nucleotide transport and metabolism]; Region: URH1; COG1957 1310161007492 active site 1310161007493 Membrane protease subunits, stomatin/prohibitin homologs [Posttranslational modification, protein turnover, chaperones]; Region: HflC; COG0330 1310161007494 A subgroup of the band 7 domain of flotillin (reggie) like proteins. This subgroup contains proteins similar to stomatin, prohibitin, flotillin, HlfK/C and podicin. Many of these band 7 domain-containing proteins are lipid raft-associated. Individual...; Region: Band_7_2; cd03402 1310161007495 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4877 1310161007496 Methyladenine glycosylase; Region: Adenine_glyco; pfam03352 1310161007497 bifunctional nitric oxide dioxygenase/dihydropteridine reductase 2; Provisional; Region: PRK13289 1310161007498 Globins are heme proteins, which bind and transport oxygen. This family summarizes a diverse set of homologous protein domains, including: (1) tetrameric vertebrate hemoglobins, which are the major protein component of erythrocytes and transport oxygen...; Region: globin; cd01040 1310161007499 heme-binding site [chemical binding]; other site 1310161007500 FAD_NAD(P)H binding domain of flavohemoglobin. Flavohemoglobins have a globin domain containing a B-type heme fused with a ferredoxin reductase-like FAD/NAD-binding domain. Flavohemoglobins detoxify nitric oxide (NO) via an NO dioxygenase reaction. The...; Region: flavohem_like_fad_nad_binding; cd06184 1310161007501 FAD binding pocket [chemical binding]; other site 1310161007502 FAD binding motif [chemical binding]; other site 1310161007503 phosphate binding motif [ion binding]; other site 1310161007504 beta-alpha-beta structure motif; other site 1310161007505 NAD binding pocket [chemical binding]; other site 1310161007506 Heme binding pocket [chemical binding]; other site 1310161007507 Domain of unknown function (DUF1707); Region: DUF1707; pfam08044 1310161007508 Predicted dinucleotide-binding enzymes [General function prediction only]; Region: COG2085 1310161007509 NADP oxidoreductase coenzyme F420-dependent; Region: F420_oxidored; pfam03807 1310161007514 aminotransferase AlaT; Validated; Region: PRK09265 1310161007515 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 1310161007516 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1310161007517 homodimer interface [polypeptide binding]; other site 1310161007518 catalytic residue [active] 1310161007519 Transposase and inactivated derivatives, IS30 family [DNA replication, recombination, and repair]; Region: Tra8; COG2826 1310161007520 Helix-turn-helix domain; Region: HTH_38; pfam13936 1310161007521 Homeodomain-like domain; Region: HTH_32; pfam13565 1310161007522 Integrase core domain; Region: rve; pfam00665 1310161007523 Predicted multitransmembrane protein [Function unknown]; Region: COG5438 1310161007524 Predicted UDP-glucose 6-dehydrogenase [Cell envelope biogenesis, outer membrane]; Region: Ugd; COG1004 1310161007525 UDP-glucose/GDP-mannose dehydrogenase family, central domain; Region: UDPG_MGDP_dh; pfam00984 1310161007526 UDP binding domain; Region: UDPG_MGDP_dh_C; smart00984 1310161007527 Trimeric dUTP diphosphatases; Region: trimeric_dUTPase; cd07557 1310161007528 trimer interface [polypeptide binding]; other site 1310161007529 active site 1310161007530 Htaa; Region: HtaA; pfam04213 1310161007531 Uncharacterized vancomycin resistance protein [Defense mechanisms]; Region: COG2720 1310161007532 Putative peptidoglycan binding domain; Region: PG_binding_4; pfam12229 1310161007533 VanW like protein; Region: VanW; pfam04294 1310161007534 Beta-glucosidase-related glycosidases [Carbohydrate transport and metabolism]; Region: BglX; COG1472 1310161007535 Glycosyl hydrolase family 3 N terminal domain; Region: Glyco_hydro_3; cl07971 1310161007536 Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293 1310161007537 Ligand Binding Site [chemical binding]; other site 1310161007538 Protein of unknown function (DUF2613); Region: DUF2613; pfam11021 1310161007539 Domain of unknown function (DUF3367); Region: DUF3367; pfam11847 1310161007540 Predicted acyltransferases [Lipid metabolism]; Region: COG1835 1310161007541 Protein of unknown function (DUF3068); Region: DUF3068; pfam11271 1310161007542 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 1310161007543 This family is most closely related to the GT1 family of glycosyltransferases and named after YqgM in Bacillus licheniformis about which little is known. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to...; Region: GT1_YqgM_like; cd03801 1310161007544 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 1310161007545 S-adenosylmethionine binding site [chemical binding]; other site 1310161007546 Phosphoenolpyruvate carboxykinase (PEPCK), a critical gluconeogenic enzyme, catalyzes the first committed step in the diversion of tricarboxylic acid cycle intermediates toward gluconeogenesis. It catalyzes the reversible decarboxylation and...; Region: PEPCK_GTP; cd00819 1310161007547 active site 1310161007548 substrate-binding site [chemical binding]; other site 1310161007549 metal-binding site [ion binding] 1310161007550 GTP binding site [chemical binding]; other site 1310161007551 Tellurite resistance protein and related permeases [Inorganic ion transport and metabolism]; Region: TehA; COG1275 1310161007552 The Tellurite-resistance/Dicarboxylate Transporter (TDT) family; Region: TDT_like_2; cd09320 1310161007553 gating phenylalanine in ion channel; other site 1310161007554 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 1310161007555 S-adenosylmethionine binding site [chemical binding]; other site 1310161007556 LabA_like proteins; Region: LabA_like; cd06167 1310161007557 putative metal binding site [ion binding]; other site 1310161007558 MMPL family; Region: MMPL; pfam03176 1310161007559 MMPL family; Region: MMPL; pfam03176 1310161007560 Predicted integral membrane protein [Function unknown]; Region: COG0392 1310161007561 Protein of unknown function (DUF3054); Region: DUF3054; pfam11255 1310161007562 Acetyl-CoA carboxylase, carboxyltransferase component (subunits alpha and beta) [Lipid metabolism]; Region: COG4799 1310161007563 malonate decarboxylase subunit beta; Reviewed; Region: PRK07189; cl17682 1310161007564 Acetyl-CoA carboxylase alpha subunit [Lipid metabolism]; Region: AccA; cl17345 1310161007565 Phosphopantetheine attachment site; Region: PKS_PP; smart00823 1310161007566 Polyketide synthase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG3321 1310161007567 polyketide synthases (PKSs) polymerize simple fatty acids into a large variety of different products, called polyketides, by successive decarboxylating Claisen condensations. PKSs can be divided into 2 groups, modular type I PKSs consisting of one or...; Region: PKS; cd00833 1310161007568 active site 1310161007569 Acyl transferase domain in polyketide synthase (PKS) enzymes; Region: PKS_AT; smart00827 1310161007570 Phosphopantetheine attachment site; Region: PKS_PP; smart00823 1310161007571 Thioesterase domains of type I polyketide synthases or non-ribosomal peptide synthetases [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG3319 1310161007572 long-chain-fatty-acid--CoA ligase; Validated; Region: PRK07769 1310161007573 Fatty acyl-AMP ligase (FAAL); Region: FAAL; cd05931 1310161007574 acyl-activating enzyme (AAE) consensus motif; other site 1310161007575 active site 1310161007576 Cutinase; Region: Cutinase; pfam01083 1310161007577 Putative esterase; Region: Esterase; pfam00756 1310161007578 S-formylglutathione hydrolase; Region: PLN02442 1310161007579 Uncharacterized protein potentially involved in peptidoglycan biosynthesis [Cell envelope biogenesis, outer membrane]; Region: COG5479 1310161007580 LGFP repeat; Region: LGFP; pfam08310 1310161007581 LGFP repeat; Region: LGFP; pfam08310 1310161007582 LGFP repeat; Region: LGFP; pfam08310 1310161007583 Domain of unknown function (DUF222); Region: DUF222; pfam02720 1310161007584 HNH nucleases; HNH endonuclease signature which is found in viral, prokaryotic, and eukaryotic proteins. The alignment includes members of the large group of homing endonucleases, yeast intron 1 protein, MutS, as well as bacterial colicins, pyocins, and...; Region: HNHc; cd00085 1310161007585 active site 1310161007586 Putative esterase; Region: Esterase; pfam00756 1310161007587 S-formylglutathione hydrolase; Region: PLN02442 1310161007588 phosphoribose diphosphate:decaprenyl-phosphate phosphoribosyltransferase; Provisional; Region: PRK12324 1310161007589 UbiA prenyltransferase family; Region: UbiA; pfam01040 1310161007590 Membrane-associated phospholipid phosphatase [Lipid metabolism]; Region: PgpB; COG0671 1310161007591 PAP2_like proteins, a super-family of histidine phosphatases and vanadium haloperoxidases, includes type 2 phosphatidic acid phosphatase or lipid phosphate phosphatase (LPP), Glucose-6-phosphatase, Phosphatidylglycerophosphatase B and bacterial acid...; Region: PAP2_like; cd01610 1310161007592 active site 1310161007593 Predicted glycosyltransferases [General function prediction only]; Region: COG1216 1310161007594 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394 1310161007595 PAP2_like_2 proteins. PAP2 is a super-family of phosphatases and haloperoxidases. This subgroup, which is specific to bacteria, lacks functional characterization and may act as a membrane-associated lipid phosphatase; Region: PAP2_like_2; cd03392 1310161007596 active site 1310161007597 Membrane-associated phospholipid phosphatase [Lipid metabolism]; Region: PgpB; COG0671 1310161007598 Predicted flavoprotein involved in K+ transport [Inorganic ion transport and metabolism]; Region: TrkA; COG2072 1310161007599 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500 1310161007600 UDP-galactopyranose mutase [Cell envelope biogenesis, outer membrane]; Region: Glf; COG0562 1310161007601 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450 1310161007602 UDP-galactopyranose mutase; Region: GLF; pfam03275 1310161007603 Uncharacterized protein potentially involved in peptidoglycan biosynthesis [Cell envelope biogenesis, outer membrane]; Region: COG5479 1310161007604 Peptidoglycan recognition proteins (PGRPs) are pattern recognition receptors that bind, and in certain cases, hydrolyze peptidoglycans (PGNs) of bacterial cell walls. PGRPs have been divided into three classes: short PGRPs (PGRP-S), that are small (20...; Region: PGRP; cd06583 1310161007605 amidase catalytic site [active] 1310161007606 Zn binding residues [ion binding]; other site 1310161007607 substrate binding site [chemical binding]; other site 1310161007608 LGFP repeat; Region: LGFP; pfam08310 1310161007609 glycerol kinase; Provisional; Region: glpK; PRK00047 1310161007610 Cellulomonas sp. glycerol kinase-like proteins; belongs to the FGGY family of carbohydrate kinases; Region: FGGY_CsGK_like; cd07789 1310161007611 N- and C-terminal domain interface [polypeptide binding]; other site 1310161007612 active site 1310161007613 MgATP binding site [chemical binding]; other site 1310161007614 catalytic site [active] 1310161007615 metal binding site [ion binding]; metal-binding site 1310161007616 putative homotetramer interface [polypeptide binding]; other site 1310161007617 glycerol binding site [chemical binding]; other site 1310161007618 homodimer interface [polypeptide binding]; other site 1310161007619 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 1310161007620 haloacid dehalogenase-like hydrolase; Region: Hydrolase_3; pfam08282 1310161007621 active site 1310161007622 motif I; other site 1310161007623 motif II; other site 1310161007624 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 1310161007625 1-acyl-sn-glycerol-3-phosphate acyltransferase [Lipid metabolism]; Region: PlsC; COG0204 1310161007626 Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: AGPAT-like; Region: LPLAT_AGPAT-like; cd07989 1310161007627 putative acyl-acceptor binding pocket; other site 1310161007628 seryl-tRNA synthetase; Provisional; Region: PRK05431 1310161007629 Seryl-tRNA synthetase N-terminal domain; Region: Seryl_tRNA_N; pfam02403 1310161007630 Seryl-tRNA synthetase (SerRS) class II core catalytic domain. SerRS is responsible for the attachment of serine to the 3' OH group of ribose of the appropriate tRNA. This domain It is primarily responsible for ATP-dependent formation of the enzyme...; Region: SerRS_core; cd00770 1310161007631 dimer interface [polypeptide binding]; other site 1310161007632 active site 1310161007633 motif 1; other site 1310161007634 motif 2; other site 1310161007635 motif 3; other site 1310161007636 Transcriptional regulators [Transcription]; Region: PhnF; COG2188 1310161007637 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 1310161007638 DNA-binding site [nucleotide binding]; DNA binding site 1310161007639 UTRA domain; Region: UTRA; pfam07702 1310161007640 Minimal MMP-like domain found in Acidothermus cellulolyticus hypothetical protein ACEL2062 and similar protein; Region: MMP_ACEL2062; cd12952 1310161007641 Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067 1310161007642 catalytic core [active] 1310161007643 prephenate dehydratase; Provisional; Region: PRK11898 1310161007644 Prephenate dehydratase; Region: PDT; pfam00800 1310161007645 C-terminal ACT domain of the bifunctional chorismate mutase-prephenate dehydratase (CM-PDT) enzyme and the prephenate dehydratase (PDT) enzyme; Region: ACT_CM-PDT; cd04905 1310161007646 putative L-Phe binding site [chemical binding]; other site 1310161007647 Asp-tRNAAsn/Glu-tRNAGln amidotransferase A subunit and related amidases [Translation, ribosomal structure and biogenesis]; Region: GatA; COG0154 1310161007648 Amidase; Region: Amidase; cl11426 1310161007649 CAAX protease self-immunity; Region: Abi; pfam02517 1310161007650 Transcriptional regulator [Transcription]; Region: LytR; COG1316 1310161007651 Protein of unknown function (DUF3500); Region: DUF3500; pfam12006 1310161007652 Uncharacterized homolog of gamma-carboxymuconolactone decarboxylase subunit [Function unknown]; Region: COG0599 1310161007653 Protein of unknown function (DUF3500); Region: DUF3500; pfam12006 1310161007654 Glycerophosphoryl diester phosphodiesterase [Energy production and conversion]; Region: UgpQ; COG0584 1310161007655 Glycerophosphodiester phosphodiesterase domain of uncharacterized bacterial glycerophosphodiester phosphodiesterases; Region: GDPD_like_2; cd08582 1310161007656 putative active site [active] 1310161007657 catalytic site [active] 1310161007658 putative metal binding site [ion binding]; other site 1310161007659 H+/gluconate symporter and related permeases [Carbohydrate transport and metabolism / Amino acid transport and metabolism]; Region: GntT; COG2610 1310161007660 fructuronate transporter; Provisional; Region: PRK10034; cl15264 1310161007661 pyruvate kinase; Provisional; Region: PRK14725 1310161007662 Pyruvate kinase [Carbohydrate transport and metabolism]; Region: PykF; COG0469 1310161007663 active site 1310161007664 L-lactate dehydrogenase; Reviewed; Region: ldh; PRK00066 1310161007665 L-2-hydroxyisocapronate dehydrogenases and some bacterial L-lactate dehydrogenases; Region: HicDH_like; cd05291 1310161007666 tetramer (dimer of dimers) interface [polypeptide binding]; other site 1310161007667 NAD binding site [chemical binding]; other site 1310161007668 dimer interface [polypeptide binding]; other site 1310161007669 substrate binding site [chemical binding]; other site 1310161007670 Predicted membrane protein [Function unknown]; Region: COG4425 1310161007671 Predicted membrane protein (DUF2319); Region: DUF2319; pfam10081 1310161007672 Predicted hydrolase (HAD superfamily) [General function prediction only]; Region: COG1011 1310161007673 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 1310161007674 motif II; other site 1310161007675 Predicted flavoprotein [General function prediction only]; Region: COG0431 1310161007676 NADPH-dependent FMN reductase; Region: FMN_red; pfam03358 1310161007677 Calcineurin-like phosphoesterase; Region: Metallophos; pfam00149 1310161007678 metallophosphatase superfamily, metallophosphatase domain; Region: MPP_superfamily; cl13995 1310161007679 active site 1310161007680 metal binding site [ion binding]; metal-binding site 1310161007681 metabolite-proton symporter; Region: 2A0106; TIGR00883 1310161007682 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1310161007683 putative substrate translocation pore; other site 1310161007684 Isopentenyl diphosphate isomerase (BS_ypgA, MTH48 and related proteins) [Coenzyme transport and metabolism]; Region: idi; COG1304 1310161007685 Family of homologous FMN-dependent alpha-hydroxyacid oxidizing enzymes. This family occurs in both prokaryotes and eukaryotes. Members of this family include flavocytochrome b2 (FCB2), glycolate oxidase (GOX), lactate monooxygenase (LMO), mandelate...; Region: alpha_hydroxyacid_oxid_FMN; cd02809 1310161007686 active site 1310161007687 substrate binding site [chemical binding]; other site 1310161007688 FMN binding site [chemical binding]; other site 1310161007689 putative catalytic residues [active] 1310161007690 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 1310161007691 non-specific DNA binding site [nucleotide binding]; other site 1310161007692 salt bridge; other site 1310161007693 sequence-specific DNA binding site [nucleotide binding]; other site 1310161007696 Calcineurin-like phosphoesterase; Region: Metallophos; pfam00149 1310161007697 metallophosphatase superfamily, metallophosphatase domain; Region: MPP_superfamily; cl13995 1310161007698 Uncharacterized conserved protein [Function unknown]; Region: COG4894 1310161007699 Zinc peptidases M18, M20, M28, and M42; Region: Zinc_peptidase_like; cl14876 1310161007700 Metal-dependent amidase/aminoacylase/carboxypeptidase [General function prediction only]; Region: AbgB; COG1473 1310161007701 metal binding site [ion binding]; metal-binding site 1310161007702 Zinc peptidases M18, M20, M28, and M42; Region: Zinc_peptidase_like; cl14876 1310161007703 methionine sulfoxide reductase A; Provisional; Region: PRK00058 1310161007704 Superoxide dismutase [Inorganic ion transport and metabolism]; Region: SodA; COG0605 1310161007705 Iron/manganese superoxide dismutases, alpha-hairpin domain; Region: Sod_Fe_N; pfam00081 1310161007706 Iron/manganese superoxide dismutases, C-terminal domain; Region: Sod_Fe_C; pfam02777 1310161007707 Transcriptional regulator [Transcription]; Region: LysR; COG0583 1310161007708 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 1310161007709 The substrate binding domain of LysR-type transcriptional regulator GltC, which activates gltA expression of glutamate synthase operon, contains type 2 periplasmic binding fold; Region: PBP2_GltC_like; cd08434 1310161007710 putative dimerization interface [polypeptide binding]; other site 1310161007711 Cupredoxin-like domain; Region: Cupredoxin_1; cl17234 1310161007712 Predicted nuclease (RecB family) [General function prediction only]; Region: COG2251 1310161007713 DnaQ-like (or DEDD) 3'-5' exonuclease domain superfamily; Region: DnaQ_like_exo; cl10012 1310161007714 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1310161007715 Major Facilitator Superfamily; Region: MFS_1; pfam07690 1310161007716 putative substrate translocation pore; other site 1310161007717 Transcriptional regulators [Transcription]; Region: MarR; COG1846 1310161007718 MarR family; Region: MarR_2; pfam12802 1310161007719 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 1310161007720 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1310161007721 active site 1310161007722 phosphorylation site [posttranslational modification] 1310161007723 intermolecular recognition site; other site 1310161007724 dimerization interface [polypeptide binding]; other site 1310161007725 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 1310161007726 DNA binding residues [nucleotide binding] 1310161007727 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: COG4585 1310161007728 Histidine kinase; Region: HisKA_3; pfam07730 1310161007729 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1310161007730 ATP binding site [chemical binding]; other site 1310161007731 Mg2+ binding site [ion binding]; other site 1310161007732 G-X-G motif; other site 1310161007733 Domain of unknown function (DUF2020); Region: DUF2020; pfam09449 1310161007734 Sortase D (SrtD) is a membrane transpeptidase found in gram-positive bacteria that anchors surface proteins to peptidoglycans of the bacterial cell wall envelope. This involves a transpeptidation reaction in which the surface protein substrate is cleaved...; Region: Sortase_D_5; cd05830 1310161007735 active site 1310161007736 catalytic site [active] 1310161007737 putative inner membrane protein translocase component YidC; Validated; Region: PRK00247 1310161007738 60Kd inner membrane protein; Region: 60KD_IMP; cl00489 1310161007739 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 1310161007740 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 1310161007741 Transglycosylase associated protein; Region: Transgly_assoc; cl00978 1310161007742 Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293 1310161007743 Ligand Binding Site [chemical binding]; other site 1310161007744 Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293 1310161007745 Ligand Binding Site [chemical binding]; other site 1310161007746 luciferase family oxidoreductase, group 1; Region: oxido_grp_1; TIGR03558 1310161007747 Flavin-utilizing monoxygenases; Region: Flavin_utilizing_monoxygenases; cl07892 1310161007748 Pseudouridylate synthases, 23S RNA-specific [Translation, ribosomal structure and biogenesis]; Region: RluA; COG0564 1310161007749 Pseudouridine synthase, a subgroup of the RluA family; Region: PSRA_1; cd02558 1310161007750 probable active site [active] 1310161007751 Predicted transcriptional regulators [Transcription]; Region: COG1725 1310161007752 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 1310161007753 DNA-binding site [nucleotide binding]; DNA binding site 1310161007754 LabA_like proteins; Region: LabA_like; cd06167 1310161007755 putative metal binding site [ion binding]; other site 1310161007756 Uncharacterized conserved protein [Function unknown]; Region: COG1432 1310161007757 Phage shock protein A (IM30), suppresses sigma54-dependent transcription [Transcription / Signal transduction mechanisms]; Region: PspA; COG1842 1310161007758 Integrase core domain; Region: rve; pfam00665 1310161007759 Integrase core domain; Region: rve_3; pfam13683 1310161007764 Methyltransferase domain; Region: Methyltransf_23; pfam13489 1310161007765 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 1310161007766 S-adenosylmethionine binding site [chemical binding]; other site 1310161007767 Nodulin-21 and CCC1-related protein family; Region: Nodulin-21_like_1; cd02432 1310161007768 Uncharacterized conserved protein, contains double-stranded beta-helix domain [Function unknown]; Region: COG1917 1310161007770 Ferredoxin [Energy production and conversion]; Region: COG1146 1310161007771 4Fe-4S binding domain; Region: Fer4; pfam00037 1310161007772 Uncharacterized conserved protein, contains double-stranded beta-helix domain [Function unknown]; Region: COG1917 1310161007775 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3544 1310161007776 copper-(or silver)-translocating P-type ATPase; Region: ATPase-IB1_Cu; TIGR01511 1310161007777 E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122 1310161007778 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 1310161007779 motif I; other site 1310161007780 motif II; other site 1310161007781 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 1310161007782 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 1310161007783 dimerization interface [polypeptide binding]; other site 1310161007784 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 1310161007785 dimer interface [polypeptide binding]; other site 1310161007786 phosphorylation site [posttranslational modification] 1310161007787 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1310161007788 ATP binding site [chemical binding]; other site 1310161007789 Mg2+ binding site [ion binding]; other site 1310161007790 G-X-G motif; other site 1310161007791 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 1310161007792 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1310161007793 active site 1310161007794 phosphorylation site [posttranslational modification] 1310161007795 intermolecular recognition site; other site 1310161007796 dimerization interface [polypeptide binding]; other site 1310161007797 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 1310161007798 DNA binding site [nucleotide binding] 1310161007799 Putative multicopper oxidases [Secondary metabolites biosynthesis, transport, and catabolism]; Region: SufI; COG2132 1310161007800 Multicopper oxidase; Region: Cu-oxidase_3; pfam07732 1310161007801 Multicopper oxidase; Region: Cu-oxidase; pfam00394 1310161007802 Multicopper oxidase; Region: Cu-oxidase_2; pfam07731 1310161007803 TlpA-like family; composed of TlpA, ResA, DsbE and similar proteins. TlpA, ResA and DsbE are bacterial protein disulfide reductases with important roles in cytochrome maturation. They are membrane-anchored proteins with a soluble TRX domain containing a...; Region: TlpA_like_family; cd02966 1310161007804 Thioredoxin-like; Region: Thioredoxin_8; pfam13905 1310161007805 catalytic residues [active] 1310161007806 NADPH:quinone reductase and related Zn-dependent oxidoreductases [Energy production and conversion / General function prediction only]; Region: Qor; COG0604 1310161007807 alcohol dehydrogenase and quinone reductase-like medium chain degydrogenases/reductases; Region: MDR_like_2; cd05289 1310161007808 putative NAD(P) binding site [chemical binding]; other site 1310161007809 cAMP-binding proteins - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases [Signal transduction mechanisms]; Region: Crp; COG0664 1310161007810 Crp-like helix-turn-helix domain; Region: HTH_Crp_2; pfam13545 1310161007811 Heavy-metal-associated domain (HMA) is a conserved domain of approximately 30 amino acid residues found in a number of proteins that transport or detoxify heavy metals, for example, the CPx-type heavy metal ATPases and copper chaperones. HMA domain...; Region: HMA; cd00371 1310161007812 metal-binding site [ion binding] 1310161007813 heavy metal translocating P-type ATPase; Region: ATPase-IB_hvy; TIGR01525 1310161007814 E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122 1310161007815 Soluble P-type ATPase [General function prediction only]; Region: COG4087 1310161007819 TRX family; composed of two groups: Group I, which includes proteins that exclusively encode a TRX domain; and Group II, which are composed of fusion proteins of TRX and additional domains. Group I TRX is a small ancient protein that alter the redox...; Region: TRX_family; cd02947 1310161007820 Thioredoxin-like; Region: Thioredoxin_8; pfam13905 1310161007821 catalytic residues [active] 1310161007822 Heavy-metal-associated domain (HMA) is a conserved domain of approximately 30 amino acid residues found in a number of proteins that transport or detoxify heavy metals, for example, the CPx-type heavy metal ATPases and copper chaperones. HMA domain...; Region: HMA; cd00371 1310161007823 metal-binding site [ion binding] 1310161007824 benzoate transport; Region: 2A0115; TIGR00895 1310161007825 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1310161007826 putative substrate translocation pore; other site 1310161007827 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1310161007828 Predicted transcriptional regulators [Transcription]; Region: COG1695 1310161007829 Transcriptional regulator PadR-like family; Region: PadR; pfam03551 1310161007830 replicative DNA helicase; Provisional; Region: PRK05636 1310161007831 DnaB-like helicase N terminal domain; Region: DnaB; pfam00772 1310161007832 DnaB helicase C terminal domain. The hexameric helicase DnaB unwinds the DNA duplex at the chromosome replication fork. Although the mechanism by which DnaB both couples ATP hydrolysis to translocation along DNA and denatures the duplex is unknown, a...; Region: DnaB_C; cd00984 1310161007833 Walker A motif; other site 1310161007834 ATP binding site [chemical binding]; other site 1310161007835 Walker B motif; other site 1310161007836 DNA binding loops [nucleotide binding] 1310161007837 50S ribosomal protein L9; Reviewed; Region: rplI; PRK00137 1310161007838 Ribosomal protein L9, N-terminal domain; Region: Ribosomal_L9_N; pfam01281 1310161007839 Ribosomal protein L9, C-terminal domain; Region: Ribosomal_L9_C; pfam03948 1310161007840 Single-stranded DNA-binding protein [DNA replication, recombination, and repair]; Region: Ssb; COG0629 1310161007841 SSB_OBF: A subfamily of OB folds similar to the OB fold of ssDNA-binding protein (SSB). SSBs bind with high affinity to ssDNA. They bind to and protect ssDNA intermediates during DNA metabolic pathways. All bacterial and eukaryotic SSBs studied to date...; Region: SSB_OBF; cd04496 1310161007842 dimer interface [polypeptide binding]; other site 1310161007843 ssDNA binding site [nucleotide binding]; other site 1310161007844 tetramer (dimer of dimers) interface [polypeptide binding]; other site 1310161007845 30S ribosomal protein S6; Reviewed; Region: rpsF; PRK00453 1310161007846 Predicted integral membrane protein [Function unknown]; Region: COG5650 1310161007847 Membrane carboxypeptidase (penicillin-binding protein) [Cell envelope biogenesis, outer membrane]; Region: MrcB; COG0744 1310161007848 Transglycosylase; Region: Transgly; pfam00912 1310161007849 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; pfam00905 1310161007850 Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293 1310161007851 Ligand Binding Site [chemical binding]; other site 1310161007852 Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293 1310161007853 Ligand Binding Site [chemical binding]; other site 1310161007854 Uncharacterized enzyme involved in biosynthesis of extracellular polysaccharides [General function prediction only]; Region: COG2329 1310161007855 putative rhodanese-related sulfurtransferase; Provisional; Region: PRK00142 1310161007856 Member of the Rhodanese Homology Domain superfamily. This CD includes Escherichia coli YceA, Bacillus subtilis YbfQ, and similar uncharacterized proteins; Region: RHOD_YceA; cd01518 1310161007857 active site residue [active] 1310161007858 MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704 1310161007859 ABC-type antimicrobial peptide transport system, permease component [Defense mechanisms]; Region: SalY; COG0577 1310161007860 FtsX-like permease family; Region: FtsX; pfam02687 1310161007861 ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136 1310161007862 ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255 1310161007863 Walker A/P-loop; other site 1310161007864 ATP binding site [chemical binding]; other site 1310161007865 Q-loop/lid; other site 1310161007866 ABC transporter signature motif; other site 1310161007867 Walker B; other site 1310161007868 D-loop; other site 1310161007869 H-loop/switch region; other site 1310161007870 Myo-inositol-1-phosphate synthase [Lipid metabolism]; Region: INO1; COG1260 1310161007871 inositol 1-phosphate synthase, Actinobacterial type; Region: mycothiol_INO1; TIGR03450 1310161007872 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4868 1310161007873 hypothetical protein; Provisional; Region: PRK13663 1310161007874 DNA-binding ferritin-like protein (oxidative damage protectant) [Inorganic ion transport and metabolism]; Region: Dps; COG0783 1310161007875 DPS protein, ferritin-like diiron-binding domain; Region: DPS; cd01043 1310161007876 dimerization interface [polypeptide binding]; other site 1310161007877 DPS ferroxidase diiron center [ion binding]; other site 1310161007878 ion pore; other site 1310161007879 Formamidopyrimidine-DNA glycosylase [DNA replication, recombination, and repair]; Region: Nei; COG0266 1310161007880 N-terminal domain of the actinomycetal Nei1 and related DNA glycosylases; Region: AcNei1_N; cd08970 1310161007881 putative DNA binding site [nucleotide binding]; other site 1310161007882 catalytic residue [active] 1310161007883 putative H2TH interface [polypeptide binding]; other site 1310161007884 putative catalytic residues [active] 1310161007885 Formamidopyrimidine-DNA glycosylase H2TH domain; Region: H2TH; pfam06831 1310161007886 Uncharacterized protein family UPF0027; Region: UPF0027; pfam01139 1310161007887 hypothetical protein; Reviewed; Region: PRK09588 1310161007888 Uncharacterized conserved protein [Function unknown]; Region: COG1434 1310161007889 YdcF-like. YdcF-like is a large family of mainly bacterial proteins, with a few members found in fungi, plants, and archaea. Escherichia coli YdcF has been shown to bind S-adenosyl-L-methionine (AdoMet), but a biochemical function has not been...; Region: YdcF-like; cd06259 1310161007890 putative active site [active] 1310161007891 Methylated DNA-protein cysteine methyltransferase [DNA replication, recombination, and repair]; Region: Ada; COG0350 1310161007892 6-O-methylguanine DNA methyltransferase, ribonuclease-like domain; Region: Methyltransf_1N; pfam02870 1310161007893 The DNA repair protein O6-alkylguanine-DNA alkyltransferase (ATase; also known as AGT, AGAT and MGMT) reverses O6-alkylation DNA damage by transferring O6-alkyl adducts to an active site cysteine irreversibly, without inducing DNA strand breaks. ATases...; Region: ATase; cd06445 1310161007894 DNA binding site [nucleotide binding] 1310161007895 active site 1310161007896 Arginate lyase and other MDR family members; Region: AL_MDR; cd08252 1310161007897 zinc-binding alcohol dehydrogenase family protein; Region: adh_fam_1; TIGR02817 1310161007898 putative NAD(P) binding site [chemical binding]; other site 1310161007899 dimer interface [polypeptide binding]; other site 1310161007900 Arabinose efflux permease [Carbohydrate transport and metabolism]; Region: AraJ; COG2814 1310161007901 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1310161007902 putative substrate translocation pore; other site 1310161007903 Malic enzyme [Energy production and conversion]; Region: SfcA; COG0281 1310161007904 Malic enzyme, N-terminal domain; Region: malic; pfam00390 1310161007905 NAD(P) binding domain of malic enzyme (ME), subgroup 2; Region: NAD_bind_2_malic_enz; cd05311 1310161007906 putative NAD(P) binding site [chemical binding]; other site 1310161007907 Sugar (pentulose and hexulose) kinases [Carbohydrate transport and metabolism]; Region: XylB; COG1070 1310161007908 Gluconate kinases; a subfamily of the FGGY family of carbohydrate kinases; Region: FGGY_GntK; cd07770 1310161007909 N- and C-terminal domain interface [polypeptide binding]; other site 1310161007910 active site 1310161007911 catalytic site [active] 1310161007912 metal binding site [ion binding]; metal-binding site 1310161007913 carbohydrate binding site [chemical binding]; other site 1310161007914 ATP binding site [chemical binding]; other site 1310161007915 Glycopeptide antibiotics resistance protein [Defense mechanisms]; Region: VanZ; COG4767 1310161007916 Glycopeptide antibiotics resistance protein [Defense mechanisms]; Region: VanZ; COG4767 1310161007917 ubiquinone biosynthesis hydroxylase family protein; Provisional; Region: PRK07608; cl17314 1310161007918 pyridine nucleotide-disulfide oxidoreductase; Provisional; Region: PRK07251 1310161007919 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 1310161007920 Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain; Region: Pyr_redox_dim; pfam02852 1310161007921 Glycine/D-amino acid oxidases (deaminating) [Amino acid transport and metabolism]; Region: DadA; COG0665 1310161007922 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500 1310161007923 Von Willebrand factor type A (vWA) domain was originally found in the blood coagulation protein von Willebrand factor (vWF). Typically, the vWA domain is made up of approximately 200 amino acid residues folded into a classic a/b para-rossmann type of...; Region: vWFA; cl00057 1310161007924 Uncharacterized protein containing a von Willebrand factor type A (vWA) domain [General function prediction only]; Region: COG2304 1310161007925 Von Willebrand factor type A (vWA) domain was originally found in the blood coagulation protein von Willebrand factor (vWF). Typically, the vWA domain is made up of approximately 200 amino acid residues folded into a classic a/b para-rossmann type of...; Region: vWFA; cl00057 1310161007926 Nitroreductase-like family 5. A subfamily of the nitroreductase family containing uncharacterized proteins that are similar to nitroreductase. Nitroreductase catalyzes the reduction of nitroaromatic compounds such as nitrotoluenes, nitrofurans and...; Region: Nitroreductase_5; cd02148 1310161007927 putative FMN binding site [chemical binding]; other site 1310161007928 leucyl-tRNA synthetase; Validated; Region: leuS; PRK00390 1310161007929 catalytic core domain of leucyl-tRNA synthetases; Region: LeuRS_core; cd00812 1310161007930 HIGH motif; other site 1310161007931 Leucyl-tRNA synthetase, Domain 2; Region: tRNA-synt_1_2; pfam13603 1310161007932 nucleotidyl transferase superfamily; Region: nt_trans; cl00015 1310161007933 nucleotidyl transferase superfamily; Region: nt_trans; cl00015 1310161007934 active site 1310161007935 KMSKS motif; other site 1310161007936 Anticodon-binding domain of bacterial and eukaryotic mitochondrial leucyl tRNA synthetases; Region: Anticodon_Ia_Leu_BEm; cd07958 1310161007937 tRNA binding surface [nucleotide binding]; other site 1310161007938 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2832 1310161007939 Plasmid maintenance system antidote protein [General function prediction only]; Region: VapI; COG3093 1310161007940 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 1310161007941 non-specific DNA binding site [nucleotide binding]; other site 1310161007942 salt bridge; other site 1310161007943 sequence-specific DNA binding site [nucleotide binding]; other site 1310161007944 mycothiol-dependent maleylpyruvate isomerase; Reviewed; Region: PRK09583 1310161007945 Mycothiol maleylpyruvate isomerase N-terminal domain; Region: MDMPI_N; pfam11716 1310161007946 MDMPI C-terminal domain; Region: MDMPI_C; pfam07398 1310161007947 2-keto-4-pentenoate hydratase/2-oxohepta-3-ene-1,7-dioic acid hydratase (catechol pathway) [Secondary metabolites biosynthesis, transport, and catabolism]; Region: MhpD; COG0179 1310161007948 Fumarylacetoacetate (FAA) hydrolase family; Region: FAA_hydrolase; pfam01557 1310161007949 Gentisate 1,2-dioxygenase [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG3435 1310161007950 Cupin domain; Region: Cupin_2; pfam07883 1310161007951 Sugar-specific transcriptional regulator TrmB; Region: TrmB; cl17775 1310161007952 Transcriptional regulator [Transcription]; Region: IclR; COG1414 1310161007953 Bacterial transcriptional regulator; Region: IclR; pfam01614 1310161007954 Baculoviral E56 protein, specific to ODV envelope; Region: Baculo_E56; pfam04639 1310161007955 benzoate transport; Region: 2A0115; TIGR00895 1310161007956 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1310161007957 putative substrate translocation pore; other site 1310161007958 salicylate hydroxylase; Provisional; Region: PRK08163 1310161007959 ubiquinone biosynthesis hydroxylase family protein; Provisional; Region: PRK07608; cl17314 1310161007960 Na+/H+-dicarboxylate symporters [Energy production and conversion]; Region: GltP; COG1301 1310161007961 Sodium:dicarboxylate symporter family; Region: SDF; pfam00375 1310161007962 SdpI/YhfL protein family; Region: SdpI; pfam13630 1310161007963 Predicted integral membrane protein [Function unknown]; Region: COG5658 1310161007964 anthranilate synthase component I; Provisional; Region: PRK13564 1310161007965 Anthranilate synthase component I, N terminal region; Region: Anth_synt_I_N; pfam04715 1310161007966 chorismate binding enzyme; Region: Chorismate_bind; pfam00425 1310161007967 Type 1 glutamine amidotransferase (GATase1) domain found in Anthranilate synthase; Region: GATase1_Anthranilate_Synthase; cd01743 1310161007968 Glutamine amidotransferase class-I; Region: GATase; pfam00117 1310161007969 glutamine binding [chemical binding]; other site 1310161007970 catalytic triad [active] 1310161007971 anthranilate phosphoribosyltransferase; Provisional; Region: trpD; PRK00188 1310161007972 Glycosyl transferase family, helical bundle domain; Region: Glycos_trans_3N; pfam02885 1310161007973 Glycosyl transferase family, a/b domain; Region: Glycos_transf_3; pfam00591 1310161007974 bifunctional indole-3-glycerol phosphate synthase/phosphoribosylanthranilate isomerase; Provisional; Region: PRK09427 1310161007975 Indole-3-glycerol phosphate synthase (IGPS); an enzyme in the tryptophan biosynthetic pathway, catalyzing the ring closure reaction of 1-(o-carboxyphenylamino)-1-deoxyribulose-5-phosphate (CdRP) to indole-3-glycerol phosphate (IGP), accompanied by the...; Region: IGPS; cd00331 1310161007976 active site 1310161007977 ribulose/triose binding site [chemical binding]; other site 1310161007978 phosphate binding site [ion binding]; other site 1310161007979 substrate (anthranilate) binding pocket [chemical binding]; other site 1310161007980 product (indole) binding pocket [chemical binding]; other site 1310161007981 Phosphoribosylanthranilate isomerase (PRAI) catalyzes the fourth step of the tryptophan biosynthesis, the conversion of N-(5'- phosphoribosyl)-anthranilate (PRA) to 1-(o-carboxyphenylamino)- 1-deoxyribulose 5-phosphate (CdRP). Most PRAIs are...; Region: PRAI; cd00405 1310161007982 active site 1310161007983 tryptophan synthase, beta subunit; Region: trpB; TIGR00263 1310161007984 Tryptophan synthase-beta: Trptophan synthase is a bifunctional enzyme that catalyses the last two steps in the biosynthesis of L-tryptophan via its alpha and beta reactions. In the alpha reaction, indole 3-glycerol phosphate is cleaved reversibly to...; Region: Trp-synth_B; cd06446 1310161007985 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1310161007986 catalytic residue [active] 1310161007987 tryptophan synthase alpha subunit; Provisional; Region: trpA; CHL00200 1310161007988 Ttryptophan synthase (TRPS) alpha subunit (TSA). TPRS is a bifunctional tetrameric enzyme (2 alpha and 2 beta subunits) that catalyzes the last two steps of L-tryptophan biosynthesis. Alpha and beta subunit catalyze two distinct reactions which are both...; Region: Tryptophan_synthase_alpha; cd04724 1310161007989 substrate binding site [chemical binding]; other site 1310161007990 active site 1310161007991 catalytic residues [active] 1310161007992 heterodimer interface [polypeptide binding]; other site 1310161007993 PTS system ascorbate-specific transporter subunit IIC; Reviewed; Region: ulaA; PRK09410 1310161007994 PTS_IIA, PTS system, fructose/mannitol specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_fru; cd00211 1310161007995 active site 1310161007996 phosphorylation site [posttranslational modification] 1310161007997 PTS_IIB_ascorbate: subunit IIB of enzyme II (EII) of the L-ascorbate-specific phosphoenolpyruvate:carbohydrate phosphotransferase system (PTS). In this system, EII is an L-ascorbate-specific permease with two cytoplasmic subunits (IIA and IIB) and a...; Region: PTS_IIB_ascorbate; cd05563 1310161007998 active site 1310161007999 P-loop; other site 1310161008000 phosphorylation site [posttranslational modification] 1310161008001 ABC-type multidrug transport system, ATPase component [Defense mechanisms]; Region: CcmA; COG1131 1310161008002 ATP-binding cassette domain of the drug resistance transporter and related proteins, subfamily A; Region: ABC_DR_subfamily_A; cd03230 1310161008003 Walker A/P-loop; other site 1310161008004 ATP binding site [chemical binding]; other site 1310161008005 Q-loop/lid; other site 1310161008006 ABC transporter signature motif; other site 1310161008007 Walker B; other site 1310161008008 D-loop; other site 1310161008009 H-loop/switch region; other site 1310161008010 Putative exporter of polyketide antibiotics [Cell envelope biogenesis, outer membrane]; Region: TnrB3; COG3559 1310161008011 Rieske domain; a [2Fe-2S] cluster binding domain commonly found in Rieske non-heme iron oxygenase (RO) systems such as naphthalene and biphenyl dioxygenases, as well as in plant/cyanobacterial chloroplast b6f and mitochondrial cytochrome bc(1) complexes; Region: Rieske; cd03467 1310161008012 iron-sulfur cluster [ion binding]; other site 1310161008013 [2Fe-2S] cluster binding site [ion binding]; other site 1310161008014 Predicted Na+-dependent transporter [General function prediction only]; Region: COG0385 1310161008015 SBF-like CPA transporter family (DUF4137); Region: DUF4137; pfam13593 1310161008016 Uncharacterized conserved protein [Function unknown]; Region: COG3358 1310161008017 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 1310161008018 putative DNA binding site [nucleotide binding]; other site 1310161008019 NADH:flavin oxidoreductases, Old Yellow Enzyme family [Energy production and conversion]; Region: NemA; COG1902 1310161008020 Old yellow enzyme (OYE) YqjM-like FMN binding domain. YqjM is involved in the oxidative stress response of Bacillus subtilis. Like the other OYE members, each monomer of YqjM contains FMN as a non-covalently bound cofactor and uses NADPH as a reducing...; Region: OYE_YqiM_FMN; cd02932 1310161008021 active site 1310161008022 FMN binding site [chemical binding]; other site 1310161008023 substrate binding site [chemical binding]; other site 1310161008024 homotetramer interface [polypeptide binding]; other site 1310161008025 catalytic residue [active] 1310161008026 atypical (a) SDRs, subgroup 5; Region: SDR_a5; cd05243 1310161008027 NADH(P)-binding; Region: NAD_binding_10; pfam13460 1310161008028 NAD(P) binding site [chemical binding]; other site 1310161008029 putative active site [active] 1310161008031 short chain dehydrogenase; Provisional; Region: PRK08267 1310161008032 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 1310161008033 NAD(P) binding site [chemical binding]; other site 1310161008034 active site 1310161008035 mttA/Hcf106 family; Region: MttA_Hcf106; pfam02416 1310161008036 twin arginine translocase protein A; Provisional; Region: tatA; PRK00575 1310161008037 Dipeptide/tripeptide permease [Amino acid transport and metabolism]; Region: PTR2; COG3104 1310161008038 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1310161008039 putative substrate translocation pore; other site 1310161008040 POT family; Region: PTR2; cl17359 1310161008041 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 1310161008042 Intradiol dioxygenases catalyze the critical ring-cleavage step in the conversion of catecholate derivatives to citric acid cycle intermediates. This family contains catechol 1,2-dioxygenases and protocatechuate 3,4-dioxygenases which are mononuclear...; Region: intradiol_dioxygenase; cl17208 1310161008043 Protocatechuate 3,4-dioxygenase beta subunit [Secondary metabolites biosynthesis, transport, and catabolism]; Region: PcaH; COG3485 1310161008044 active site 1310161008045 Alcohol dehydrogenase, class IV [Energy production and conversion]; Region: EutG; COG1454 1310161008046 Maleylacetate reductase is involved in many aromatic compounds degradation pathways of aerobic microbes; Region: MAR; cd08177 1310161008047 active site 1310161008048 dimer interface [polypeptide binding]; other site 1310161008049 metal binding site [ion binding]; metal-binding site 1310161008050 Sugar (and other) transporter; Region: Sugar_tr; pfam00083 1310161008051 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1310161008052 putative substrate translocation pore; other site 1310161008053 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1310161008054 Transcriptional regulator [Transcription]; Region: IclR; COG1414 1310161008055 Sugar-specific transcriptional regulator TrmB; Region: TrmB; cl17775 1310161008056 Transcriptional regulator [Transcription]; Region: IclR; COG1414 1310161008057 IclR helix-turn-helix domain; Region: HTH_IclR; cl17605 1310161008058 Bacterial transcriptional regulator; Region: IclR; pfam01614 1310161008059 Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673 1310161008060 Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408 1310161008061 Oxidoreductase family, C-terminal alpha/beta domain; Region: GFO_IDH_MocA_C; pfam02894 1310161008062 Sugar phosphate isomerases/epimerases [Carbohydrate transport and metabolism]; Region: IolE; COG1082 1310161008063 Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673 1310161008064 Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408 1310161008065 Oxidoreductase family, C-terminal alpha/beta domain; Region: GFO_IDH_MocA_C; pfam02894 1310161008066 Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673 1310161008067 Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408 1310161008068 Oxidoreductase family, C-terminal alpha/beta domain; Region: GFO_IDH_MocA_C; pfam02894 1310161008069 Lamin Tail Domain; Region: LTD; pfam00932 1310161008070 Bacterial Ig-like domain (group 3); Region: Big_3_3; pfam13750 1310161008071 Bacillus subtilis YvnB and related proteins, metallophosphatase domain; Region: MPP_YvnB; cd07399 1310161008072 Calcineurin-like phosphoesterase; Region: Metallophos; pfam00149 1310161008073 putative active site [active] 1310161008074 putative metal binding site [ion binding]; other site 1310161008075 proline/glycine betaine transporter; Provisional; Region: PRK10642 1310161008076 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1310161008077 putative substrate translocation pore; other site 1310161008078 Band_7_stomatin_like: A subgroup of the band 7 domain of flotillin (reggie) like proteins similar to stomatin and podicin (two lipid raft-associated integral membrane proteins). Individual proteins of this band 7 domain family may cluster to form...; Region: Band_7_stomatin_like; cd03403 1310161008079 Membrane protease subunits, stomatin/prohibitin homologs [Posttranslational modification, protein turnover, chaperones]; Region: HflC; COG0330 1310161008080 GIY-YIG nuclease domain superfamily; Region: GIY-YIG_SF; cd00719 1310161008081 GIY-YIG motif/motif A; other site 1310161008082 active site 1310161008083 catalytic site [active] 1310161008084 metal binding site [ion binding]; metal-binding site 1310161008085 Predicted helicase [General function prediction only]; Region: COG4889 1310161008086 Restriction endonuclease; Region: Mrr_cat_2; pfam13156 1310161008087 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 1310161008088 ATP binding site [chemical binding]; other site 1310161008089 putative Mg++ binding site [ion binding]; other site 1310161008090 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 1310161008091 ATP-binding site [chemical binding]; other site 1310161008092 Domain of unknown function (DUF4395); Region: DUF4395; pfam14340 1310161008094 The DNA repair protein O6-alkylguanine-DNA alkyltransferase (ATase; also known as AGT, AGAT and MGMT) reverses O6-alkylation DNA damage by transferring O6-alkyl adducts to an active site cysteine irreversibly, without inducing DNA strand breaks. ATases...; Region: ATase; cl01497 1310161008095 DNA binding site [nucleotide binding] 1310161008096 active site 1310161008097 Heavy-metal-associated domain (HMA) is a conserved domain of approximately 30 amino acid residues found in a number of proteins that transport or detoxify heavy metals, for example, the CPx-type heavy metal ATPases and copper chaperones. HMA domain...; Region: HMA; cd00371 1310161008098 metal-binding site [ion binding] 1310161008099 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1310161008100 ABC-type Fe3+-citrate transport system, periplasmic component [Inorganic ion transport and metabolism]; Region: FecB; COG4594 1310161008101 Fe3+-siderophore binding domain FhuD. These proteins have been shown to function as initial receptors in ABC transport of Fe3+-siderophores in many eubacterial species. They belong to the TroA-like superfamily of helical backbone metal receptor proteins...; Region: FhuD; cd01146 1310161008102 siderophore binding site; other site 1310161008103 NADPH:quinone reductase and related Zn-dependent oxidoreductases [Energy production and conversion / General function prediction only]; Region: Qor; COG0604 1310161008104 2-enoyl thioester reductase (ETR) like proteins, child 2; Region: ETR_like_2; cd08292 1310161008105 putative NAD(P) binding site [chemical binding]; other site 1310161008106 putative dimer interface [polypeptide binding]; other site 1310161008107 Predicted membrane protein [Function unknown]; Region: COG3759 1310161008108 4-amino-5-hydroxymethyl-2-methyl-pyrimidine phosphate kinase (HMPP-kinase) catalyzes two consecutive phosphorylation steps in the thiamine phosphate biosynthesis pathway, leading to the synthesis of vitamin B1. The first step is the phosphorylation of...; Region: HMPP_kinase; cd01169 1310161008109 substrate binding site [chemical binding]; other site 1310161008110 dimer interface [polypeptide binding]; other site 1310161008111 ATP binding site [chemical binding]; other site 1310161008112 Copper chaperone [Inorganic ion transport and metabolism]; Region: CopZ; COG2608 1310161008113 metal-binding site [ion binding] 1310161008114 Predicted branched-chain amino acid permeases (azaleucine resistance) [Amino acid transport and metabolism]; Region: AzlD; COG1687 1310161008115 Predicted branched-chain amino acid permease (azaleucine resistance) [Amino acid transport and metabolism]; Region: AzlC; COG1296 1310161008116 hypothetical protein; Validated; Region: PRK00228 1310161008117 tRNA adenylyltransferase; Region: tRNA_CCA_actino; TIGR02692 1310161008118 Nucleotidyltransferase (NT) domain of ClassII CCA-adding enzymes; Region: NT_ClassII-CCAase; cd05398 1310161008119 active site 1310161008120 NTP binding site [chemical binding]; other site 1310161008121 metal binding triad [ion binding]; metal-binding site 1310161008122 Probable RNA and SrmB- binding site of polymerase A; Region: PolyA_pol_RNAbd; pfam12627 1310161008123 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 1310161008124 Zn2+ binding site [ion binding]; other site 1310161008125 Mg2+ binding site [ion binding]; other site 1310161008126 tRNA nucleotidyltransferase domain 2 putative; Region: tRNA_NucTran2_2; pfam13735 1310161008127 Diadenosine hexaphosphate (Ap6A) hydrolase is a member of the Nudix hydrolase superfamily. Ap6A hydrolase specifically hydrolyzes diadenosine polyphosphates, but not ATP or diadenosine triphosphate, and it generates ATP as the product. Ap6A, the most...; Region: Ap6A_hydrolase; cd03673 1310161008128 active site 1310161008129 Ap6A binding site [chemical binding]; other site 1310161008130 nudix motif; other site 1310161008131 metal binding site [ion binding]; metal-binding site 1310161008132 Uncharacterized membrane protein, putative virulence factor [General function prediction only]; Region: MviN; COG0728 1310161008133 MurJ/MviN, a subfamily of the multidrug and toxic compound extrusion (MATE)-like proteins; Region: MATE_MurJ_like; cd13123 1310161008134 RNA polymerase sigma factor, sigma-70 family; Region: sigma70-ECF; TIGR02937 1310161008135 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 1310161008136 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 1310161008137 DNA binding residues [nucleotide binding] 1310161008138 thioredoxin-disulfide reductase; Region: TRX_reduct; TIGR01292 1310161008139 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500 1310161008140 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 1310161008141 TRX family; composed of two groups: Group I, which includes proteins that exclusively encode a TRX domain; and Group II, which are composed of fusion proteins of TRX and additional domains. Group I TRX is a small ancient protein that alter the redox...; Region: TRX_family; cd02947 1310161008142 catalytic residues [active] 1310161008143 Putative peptidoglycan-binding domain-containing protein [Cell envelope biogenesis, outer membrane]; Region: COG3409 1310161008144 Putative peptidoglycan binding domain; Region: PG_binding_1; pfam01471 1310161008145 N-acetylmuramoyl-L-alanine amidase [Cell envelope biogenesis, outer membrane]; Region: AmiC; COG0860 1310161008146 N-acetylmuramoyl-L-alanine amidase or MurNAc-LAA (also known as peptidoglycan aminohydrolase, NAMLA amidase, NAMLAA, Amidase 3, and peptidoglycan amidase; EC 3.5.1.28) is an autolysin that hydrolyzes the amide bond between N-acetylmuramoyl and L-amino...; Region: MurNAc-LAA; cd02696 1310161008147 active site 1310161008148 metal binding site [ion binding]; metal-binding site 1310161008149 ParB/RepB/Spo0J family partition protein; Region: parB_part; TIGR00180 1310161008150 ParB-like nuclease domain; Region: ParB; smart00470 1310161008151 KorB domain; Region: KorB; pfam08535 1310161008152 ATPases involved in chromosome partitioning [Cell division and chromosome partitioning]; Region: Soj; COG1192 1310161008153 ParA and ParB of Caulobacter crescentus belong to a conserved family of bacterial proteins implicated in chromosome segregation. ParB binds to DNA sequences adjacent to the origin of replication and localizes to opposite cell poles shortly following the...; Region: ParA; cd02042 1310161008154 P-loop; other site 1310161008155 Magnesium ion binding site [ion binding]; other site 1310161008156 ParA and ParB of Caulobacter crescentus belong to a conserved family of bacterial proteins implicated in chromosome segregation. ParB binds to DNA sequences adjacent to the origin of replication and localizes to opposite cell poles shortly following the...; Region: ParA; cd02042 1310161008157 Magnesium ion binding site [ion binding]; other site 1310161008158 The Fer4_NifH superfamily contains a variety of proteins which share a common ATP-binding domain. Functionally, proteins in this superfamily use the energy from hydrolysis of NTP to transfer electron or ion; Region: Fer4_NifH; cl17203 1310161008159 Predicted S-adenosylmethionine-dependent methyltransferase involved in bacterial cell division [Cell envelope biogenesis, outer membrane]; Region: GidB; COG0357 1310161008160 16S rRNA methyltransferase GidB; Reviewed; Region: gidB; PRK00107 1310161008161 putative inner membrane protein translocase component YidC; Provisional; Region: PRK03449 1310161008162 Haemolytic domain; Region: Haemolytic; pfam01809 1310161008163 ribonuclease P; Reviewed; Region: rnpA; PRK03459