-- dump date   	20140619_044854
-- class       	Genbank::misc_feature
-- table       	misc_feature_note
-- id	note
195102000001	ATPases involved in chromosome partitioning [Cell division and chromosome partitioning]; Region: Soj; COG1192
195102000002	ParA and ParB of Caulobacter crescentus belong to a conserved family of bacterial proteins implicated in chromosome segregation. ParB binds to DNA sequences adjacent to the origin of replication and localizes to opposite cell poles shortly following the...; Region: ParA; cd02042
195102000003	P-loop; other site
195102000004	Magnesium ion binding site [ion binding]; other site
195102000005	ParA and ParB of Caulobacter crescentus belong to a conserved family of bacterial proteins implicated in chromosome segregation. ParB binds to DNA sequences adjacent to the origin of replication and localizes to opposite cell poles shortly following the...; Region: ParA; cd02042
195102000006	Magnesium ion binding site [ion binding]; other site
195102000007	nucleoid occlusion protein; Region: nucleoid_noc; TIGR04285
195102000008	ParB-like nuclease domain; Region: ParBc; pfam02195
195102000009	Transposase, Mutator family; Region: Transposase_mut; pfam00872
195102000010	Transposase, Mutator family; Region: Transposase_mut; pfam00872
195102000011	Transposase, Mutator family; Region: Transposase_mut; pfam00872
195102000012	ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255
195102000013	putative bacteriocin export ABC transporter, lactococcin 972 group; Region: L_ocin_972_ABC; TIGR03608
195102000014	Walker A/P-loop; other site
195102000015	ATP binding site [chemical binding]; other site
195102000016	Q-loop/lid; other site
195102000017	ABC transporter signature motif; other site
195102000018	Walker B; other site
195102000019	D-loop; other site
195102000020	H-loop/switch region; other site
195102000021	bacteriocin-associated integral membrane (putative immunity) protein; Region: bact_immun_7tm; TIGR01654
195102000022	Protein of unknown function (DUF1430); Region: DUF1430; pfam07242
195102000023	Transposase, Mutator family; Region: Transposase_mut; pfam00872
195102000024	multiple promoter invertase; Provisional; Region: mpi; PRK13413
195102000025	Serine Recombinase (SR) family, Resolvase and Invertase subfamily, catalytic domain; members contain a C-terminal DNA binding domain. Serine recombinases catalyze site-specific recombination of DNA molecules by a concerted, four-strand cleavage and...; Region: SR_ResInv; cd03768
195102000026	catalytic residues [active]
195102000027	catalytic nucleophile [active]
195102000028	Presynaptic Site I dimer interface [polypeptide binding]; other site
195102000029	Synaptic Antiparallel dimer interface [polypeptide binding]; other site
195102000030	Synaptic Flat tetramer interface [polypeptide binding]; other site
195102000031	Synaptic Site I dimer interface [polypeptide binding]; other site
195102000032	DNA binding site [nucleotide binding]
195102000033	Helix-turn-helix domain of resolvase; Region: HTH_7; pfam02796
195102000034	Predicted transcriptional regulators [Transcription]; Region: COG1695
195102000035	Transcriptional regulator PadR-like family; Region: PadR; pfam03551
195102000036	Mov34/MPN/PAD-1 family; Region: MPN_DUF2466; cd08071
195102000037	MPN+ (JAMM) motif; other site
195102000038	Zinc-binding site [ion binding]; other site
195102000039	YcfA-like protein; Region: YcfA; pfam07927
195102000040	Uncharacterized protein family (UPF0150); Region: UPF0150; pfam03681
195102000041	Peptidase_C39 like family; Region: Peptidase_C39_2; pfam13529
195102000042	beta propeller repeat, Methanosarcina surface protein type; Region: beta_prop_Msarc; TIGR04275
195102000043	Serine Recombinase family, catalytic domain; a DNA binding domain may be present either N- or C-terminal to the catalytic domain. These enzymes perform site-specific recombination of DNA molecules by a concerted, four-strand cleavage and rejoining...; Region: Ser_Recombinase; cl02788
195102000044	catalytic residues [active]
195102000045	CHC2 zinc finger; Region: zf-CHC2; cl17510
195102000046	Domain of unknown function (DUF955); Region: DUF955; pfam06114
195102000047	conjugal transfer relaxase TraI; Provisional; Region: PRK13878
195102000048	Soluble lytic murein transglycosylase and related regulatory proteins (some contain LysM/invasin domains) [Cell envelope biogenesis, outer membrane]; Region: MltE; COG0741
195102000049	Lytic Transglycosylase (LT)  and Goose Egg White Lysozyme (GEWL) domain. Members include the soluble and insoluble membrane-bound LTs in bacteria, the LTs in bacteriophage lambda, as well as, the eukaryotic "goose-type" lysozymes (GEWL).  LTs...; Region: LT_GEWL; cd00254
195102000050	catalytic residue [active]
195102000051	Cell wall-associated hydrolases (invasion-associated proteins) [Cell envelope biogenesis, outer membrane]; Region: Spr; COG0791
195102000052	NlpC/P60 family; Region: NLPC_P60; pfam00877
195102000053	AAA-like domain; Region: AAA_10; pfam12846
195102000054	Topoisomerase IA [DNA replication, recombination, and repair]; Region: TopA; COG0550
195102000055	TOPRIM_TopoIA_TopoIII: The topoisomerase-primase (TORPIM) domain found in members of the type IA family of DNA topoisomerases (Topo IA) similar to topoisomerase III. Type IA DNA topoisomerases remove (relax) negative supercoils in the DNA by: cleaving...; Region: TOPRIM_TopoIA_TopoIII; cd03362
195102000056	active site
195102000057	putative interdomain interaction site [polypeptide binding]; other site
195102000058	putative metal-binding site [ion binding]; other site
195102000059	putative nucleotide binding site [chemical binding]; other site
195102000060	DNA Topoisomerase, subtype IA; DNA-binding, ATP-binding and catalytic domain of bacterial DNA topoisomerases I and III, and eukaryotic DNA topoisomerase III and eubacterial and archael reverse gyrases. Topoisomerases clevage single or double stranded DNA...; Region: TOP1Ac; cl11986
195102000061	domain I; other site
195102000062	DNA binding groove [nucleotide binding]
195102000063	phosphate binding site [ion binding]; other site
195102000064	domain II; other site
195102000065	domain III; other site
195102000066	nucleotide binding site [chemical binding]; other site
195102000067	catalytic site [active]
195102000068	domain IV; other site
195102000069	type III secretion protein, YscU/HrpY family; Region: FlhB_rel_III; TIGR01404
195102000070	Type IV secretory pathway, VirD4 components [Intracellular trafficking and secretion]; Region: VirD4; COG3505
195102000071	RecA-like NTPases. This family includes the NTP binding domain of F1 and V1 H+ATPases, DnaB and related helicases as well as bacterial RecA and related eukaryotic and archaeal recombinases. This group also includes bacterial conjugation proteins and...; Region: RecA-like_NTPases; cl17233
195102000072	Walker A motif; other site
195102000073	ATP binding site [chemical binding]; other site
195102000074	Type IV secretory pathway, VirD4 components [Intracellular trafficking and secretion]; Region: VirD4; COG3505
195102000075	TraM recognition site of TraD and TraG; Region: TraG-D_C; pfam12696
195102000076	sporulation transcription factor Spo0A; Region: spore_0_A; TIGR02875
195102000077	Sortase D (SrtD) is a membrane transpeptidase found in gram-positive bacteria that anchors surface proteins to peptidoglycans of the bacterial cell wall envelope. This involves a transpeptidation reaction in which the surface protein substrate is cleaved...; Region: Sortase_D_5; cd06166
195102000078	active site
195102000079	catalytic site [active]
195102000080	Cna protein B-type domain; Region: Cna_B; pfam05738
195102000081	Cna protein B-type domain; Region: Cna_B; pfam05738
195102000082	Cna protein B-type domain; Region: Cna_B; pfam05738
195102000083	Cna protein B-type domain; Region: Cna_B; pfam05738
195102000084	Cna protein B-type domain; Region: Cna_B; pfam05738
195102000085	Cna protein B-type domain; Region: Cna_B; pfam05738
195102000086	Cna protein B-type domain; Region: Cna_B; pfam05738
195102000087	Cna protein B-type domain; Region: Cna_B; pfam05738
195102000088	Cna protein B-type domain; Region: Cna_B; pfam05738
195102000089	Cna protein B-type domain; Region: Cna_B; pfam05738
195102000090	Cna protein B-type domain; Region: Cna_B; pfam05738
195102000091	PemK-like protein; Region: PemK; pfam02452
195102000092	SCP_bacterial: SCP-like extracellular protein domain, as found in bacteria and archaea. The wider family of SCP containing proteins includes plant pathogenesis-related protein 1 (PR-1), CRISPs, mammalian cysteine-rich secretory proteins, and allergen 5...; Region: SCP_bacterial; cd05379
195102000093	C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cl17315
195102000094	DNA binding residues [nucleotide binding]
195102000095	Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396
195102000096	Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093
195102000097	non-specific DNA binding site [nucleotide binding]; other site
195102000098	salt bridge; other site
195102000099	sequence-specific DNA binding site [nucleotide binding]; other site
195102000100	Peptidase S24 LexA-like proteins are involved in the SOS response leading to the repair of single-stranded DNA within the bacterial cell. This family includes: the lambda repressor CI/C2 family and related bacterial prophage repressor proteins; LexA (EC...; Region: S24_LexA-like; cd06529
195102000101	Catalytic site [active]
195102000102	chromosomal replication initiation protein; Reviewed; Region: dnaA; PRK00149
195102000103	DnaA N-terminal domain; Region: DnaA_N; pfam11638
195102000104	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
195102000105	Walker A motif; other site
195102000106	ATP binding site [chemical binding]; other site
195102000107	Walker B motif; other site
195102000108	arginine finger; other site
195102000109	C-terminal domain of bacterial DnaA proteins. The DNA-binding C-terminal domain of DnaA contains a helix-turn-helix motif that specifically interacts with the DnaA box, a 9-mer motif that occurs repetitively in the replication origin oriC. Multiple...; Region: Bac_DnaA_C; cd06571
195102000110	DnaA box-binding interface [nucleotide binding]; other site
195102000111	DNA polymerase III subunit beta; Validated; Region: PRK05643
195102000112	Beta clamp domain.  The beta subunit (processivity factor) of DNA polymerase III holoenzyme, refered to as the beta clamp, forms a ring shaped dimer that encircles dsDNA (sliding clamp) in bacteria.  The beta-clamp is structurally similar to the trimeric...; Region: beta_clamp; cd00140
195102000113	putative DNA binding surface [nucleotide binding]; other site
195102000114	dimer interface [polypeptide binding]; other site
195102000115	beta-clamp/clamp loader binding surface; other site
195102000116	beta-clamp/translesion DNA polymerase binding surface; other site
195102000117	S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site;  Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165
195102000118	RNA binding surface [nucleotide binding]; other site
195102000119	recombination protein F; Reviewed; Region: recF; PRK00064
195102000120	ATP-binding cassette domain of RecF; Region: ABC_RecF; cd03242
195102000121	Walker A/P-loop; other site
195102000122	ATP binding site [chemical binding]; other site
195102000123	Q-loop/lid; other site
195102000124	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
195102000125	ABC transporter signature motif; other site
195102000126	Walker B; other site
195102000127	D-loop; other site
195102000128	H-loop/switch region; other site
195102000129	DNA gyrase subunit B; Validated; Region: gyrB; PRK05644
195102000130	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
195102000131	Mg2+ binding site [ion binding]; other site
195102000132	G-X-G motif; other site
195102000133	TopoIIA_Trans_DNA_gyrase: Transducer domain, having a ribosomal S5 domain 2-like fold, of the type found in proteins of the type IIA family of DNA topoisomerases similar to the B subunits of E. coli DNA gyrase and E. coli Topoisomerase IV which are; Region: TopoII_Trans_DNA_gyrase; cd00822
195102000134	anchoring element; other site
195102000135	dimer interface [polypeptide binding]; other site
195102000136	ATP binding site [chemical binding]; other site
195102000137	TOPRIM_TopoIIA_GyrB: topoisomerase-primase (TOPRIM) nucleotidyl transferase/hydrolase domain of the type found in proteins of the type IIA family of DNA topoisomerases similar to the Escherichia coli GyrB subunit. TopoIIA enzymes cut both strands of the...; Region: TOPRIM_TopoIIA_GyrB; cd03366
195102000138	active site
195102000139	putative metal-binding site [ion binding]; other site
195102000140	DNA gyrase B subunit, carboxyl terminus; Region: DNA_gyraseB_C; pfam00986
195102000141	DNA gyrase subunit A; Validated; Region: PRK05560
195102000142	DNA Topoisomerase, subtype IIA; domain A'; bacterial DNA topoisomerase IV (C subunit, ParC), bacterial DNA gyrases (A subunit, GyrA),mammalian DNA toposiomerases II. DNA topoisomerases are essential enzymes that regulate the conformational changes...; Region: TOP4c; cd00187
195102000143	CAP-like domain; other site
195102000144	active site
195102000145	primary dimer interface [polypeptide binding]; other site
195102000146	DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989
195102000147	DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989
195102000148	DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989
195102000149	DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989
195102000150	DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989
195102000151	DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989
195102000152	HDOD domain; Region: HDOD; pfam08668
195102000153	hypothetical protein; Validated; Region: PRK00068
195102000154	Uncharacterized conserved protein [Function unknown]; Region: COG1615
195102000155	Predicted dehydrogenase [General function prediction only]; Region: COG0579
195102000156	hydroxyglutarate oxidase; Provisional; Region: PRK11728
195102000157	BFD-like [2Fe-2S] binding domain; Region: Fer2_BFD; pfam04324
195102000158	Protein of unknown function (DUF1667); Region: DUF1667; cl17602
195102000159	seryl-tRNA synthetase; Provisional; Region: PRK05431
195102000160	Seryl-tRNA synthetase N-terminal domain; Region: Seryl_tRNA_N; pfam02403
195102000161	Seryl-tRNA synthetase (SerRS) class II core catalytic domain. SerRS is responsible for the attachment of serine to the 3' OH group of ribose of the appropriate tRNA. This domain It is primarily responsible for ATP-dependent formation of the enzyme...; Region: SerRS_core; cd00770
195102000162	dimer interface [polypeptide binding]; other site
195102000163	active site
195102000164	motif 1; other site
195102000165	motif 2; other site
195102000166	motif 3; other site
195102000167	Escherichia coli YbbF/LpxH and related proteins, metallophosphatase domain; Region: MPP_YbbF-LpxH; cd07398
195102000168	putative active site [active]
195102000169	putative metal binding site [ion binding]; other site
195102000170	helicase-exonuclease AddAB, AddB subunit; Region: addB_Gpos; TIGR02773
195102000171	PD-(D/E)XK nuclease superfamily; Region: PDDEXK_1; pfam12705
195102000172	helicase-exonuclease AddAB, AddA subunit, Firmicutes type; Region: addA_Gpos; TIGR02785
195102000173	Part of AAA domain; Region: AAA_19; pfam13245
195102000174	Family description; Region: UvrD_C_2; pfam13538
195102000175	PD-(D/E)XK nuclease superfamily; Region: PDDEXK_1; pfam12705
195102000176	Nucleotidyltransferase (NT) domain of ClassII CCA-adding enzymes; Region: NT_ClassII-CCAase; cd05398
195102000177	tRNA CCA-pyrophosphorylase; Provisional; Region: PRK13299
195102000178	active site
195102000179	NTP binding site [chemical binding]; other site
195102000180	metal binding triad [ion binding]; metal-binding site
195102000181	Probable RNA and SrmB- binding site of polymerase A; Region: PolyA_pol_RNAbd; pfam12627
195102000182	tRNA nucleotidyltransferase domain 2 putative; Region: tRNA_NucTran2_2; pfam13735
195102000183	3'-5' exoribonuclease YhaM; Provisional; Region: PRK13480
195102000184	YhaM_OBF_like: A subfamily of OB folds similar to that found in Bacillus subtilis YhaM and Staphylococcus aureus cmp-binding factor-1 (SaCBF1). Both these proteins are 3'-to-5'exoribonucleases. YhaM requires Mn2+ or Co2+ for activity and is...; Region: YhaM_OBF_like; cd04492
195102000185	generic binding surface II; other site
195102000186	generic binding surface I; other site
195102000187	Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077
195102000188	Zn2+ binding site [ion binding]; other site
195102000189	Mg2+ binding site [ion binding]; other site
195102000190	Uncharacterized protein conserved in bacteria [Function unknown]; Region: ErfK; COG1376
195102000191	L,D-transpeptidase catalytic domain; Region: YkuD; pfam03734
195102000192	peptidase T; Region: peptidase-T; TIGR01882
195102000193	M20 Peptidase T specifically cleaves tripeptides; Region: M20_peptT; cd03892
195102000194	metal binding site [ion binding]; metal-binding site
195102000195	dimer interface [polypeptide binding]; other site
195102000196	EDD domain protein, DegV family; Region: DegV; TIGR00762
195102000197	Uncharacterized protein, DegV family COG1307; Region: DegV; pfam02645
195102000198	Domain of unknown function (DUF1887); Region: DUF1887; pfam09002
195102000199	phosphatidylserine decarboxylase; Provisional; Region: PRK00723
195102000200	pyrimidine utilization regulatory protein R; Region: RutR; TIGR03613
195102000201	Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440
195102000202	YsiA-like protein, C-terminal region; Region: TetR_C_4; pfam08359
195102000203	Hemolysins and related proteins containing CBS domains [General function prediction only]; Region: TlyC; COG1253
195102000204	Domain of unknown function DUF21; Region: DUF21; pfam01595
195102000205	This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains associated with the CorC_HlyC domain. CorC_HlyC is a transporter associated domain. This small domain is found in Na+/H+ antiporters, in proteins involved in...; Region: CBS_pair_CorC_HlyC_assoc; cd04590
195102000206	Transporter associated domain; Region: CorC_HlyC; smart01091
195102000207	Nucleoside deaminases include adenosine, guanine and cytosine deaminases. These enzymes are Zn dependent and catalyze the deamination of nucleosides. The zinc ion in the active site plays a central role in the proposed catalytic mechanism, activating a...; Region: nucleoside_deaminase; cd01285
195102000208	nucleoside/Zn binding site; other site
195102000209	dimer interface [polypeptide binding]; other site
195102000210	catalytic motif [active]
195102000211	Protein of unknown function (DUF2809); Region: DUF2809; pfam10990
195102000212	Mannosyl-glycoprotein endo-beta-N-acetylglucosaminidase; Region: Glucosaminidase; pfam01832
195102000213	Uncharacterized conserved protein [Function unknown]; Region: COG0397
195102000214	hypothetical protein; Validated; Region: PRK00029
195102000215	Zinc dependent phospholipase C/S1-P1 nuclease; Region: ZnPC_S1P1; cd10981
195102000216	Zn binding site [ion binding]; other site
195102000217	PLAT (Polycystin-1, Lipoxygenase, Alpha-Toxin) domain or LH2 (Lipoxygenase homology 2)  domain.  It consists of an eight stranded beta-barrel. The domain can be found in various domain architectures, in case of lipoxygenases, alpha toxin, lipases and...; Region: PLAT; cd00113
195102000218	Putative GTPases (G3E family) [General function prediction only]; Region: COG0523
195102000219	The Fer4_NifH superfamily contains a variety of proteins which share a common ATP-binding domain. Functionally, proteins in this superfamily use the energy from hydrolysis of NTP to transfer electron or ion; Region: Fer4_NifH; cl17203
195102000220	Cobalamin synthesis protein cobW C-terminal domain; Region: CobW_C; smart00833
195102000221	The Fer4_NifH superfamily contains a variety of proteins which share a common ATP-binding domain. Functionally, proteins in this superfamily use the energy from hydrolysis of NTP to transfer electron or ion; Region: Fer4_NifH; cl17203
195102000222	Predicted permeases [General function prediction only]; Region: COG0701
195102000223	Domain of unknown function (DUF1980); Region: DUF1980; pfam09323
195102000224	Domain of unknown function (DUF1980); Region: DUF1980; cl01492
195102000225	prolipoprotein diacylglyceryl transferase; Reviewed; Region: PRK12437
195102000226	Branched-chain amino acid transport protein; Region: Branch_AA_trans; pfam05525
195102000227	Dihydrofolate reductase [Coenzyme metabolism]; Region: FolA; COG0262
195102000228	Dihydrofolate reductase (DHFR). Reduces 7,8-dihydrofolate to 5,6,7,8-tetrahydrofolate with NADPH as a cofactor. This is an essential step in the biosynthesis of deoxythymidine phosphate since 5,6,7,8-tetrahydrofolate is required to regenerate 5; Region: DHFR; cd00209
195102000229	folate binding site [chemical binding]; other site
195102000230	NADP+ binding site [chemical binding]; other site
195102000231	DNA polymerase III subunits gamma and tau; Validated; Region: PRK05563
195102000232	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
195102000233	Walker A motif; other site
195102000234	ATP binding site [chemical binding]; other site
195102000235	Walker B motif; other site
195102000236	arginine finger; other site
195102000237	DNA polymerase III subunits gamma and tau domain III; Region: DNA_pol3_gamma3; pfam12169
195102000238	hypothetical protein; Validated; Region: PRK00153
195102000239	recombination protein RecR; Reviewed; Region: recR; PRK00076
195102000240	RecR protein; Region: RecR; pfam02132
195102000241	TOPRIM_recR: topoisomerase-primase (TOPRIM) nucleotidyl transferase/hydrolase domain of the type found in Escherichia coli RecR.  RecR participates in the RecFOR pathway of homologous recombinational repair in prokaryotes. This pathway provides a...; Region: TOPRIM_recR; cd01025
195102000242	putative active site [active]
195102000243	putative metal-binding site [ion binding]; other site
195102000244	tetramer interface [polypeptide binding]; other site
195102000245	Protein of unknown function (DUF2508); Region: DUF2508; pfam10704
195102000246	ABC-2 family transporter protein; Region: ABC2_membrane_3; pfam12698
195102000247	Serine-pyruvate aminotransferase/archaeal aspartate aminotransferase [Amino acid transport and metabolism]; Region: COG0075
195102000248	pyridoxal 5'-phosphate binding pocket [chemical binding]; other site
195102000249	catalytic residue [active]
195102000250	Phosphoglycerate dehydrogenase and related dehydrogenases [Amino acid transport and metabolism]; Region: SerA; COG0111
195102000251	Phosphoglycerate dehydrogenase (PGDH) NAD-binding and catalytic domains; Region: PGDH_2; cd05303
195102000252	putative ligand binding site [chemical binding]; other site
195102000253	NAD binding site [chemical binding]; other site
195102000254	dimerization interface [polypeptide binding]; other site
195102000255	catalytic site [active]
195102000256	Uncharacterized conserved protein [Function unknown]; Region: COG4198
195102000257	Protein of unknown function (DUF1015); Region: DUF1015; pfam06245
195102000258	5'-methylthioadenosine/S-adenosylhomocysteine nucleosidase; Validated; Region: PRK05584
195102000259	5'-methylthioadenosine/S-adenosylhomocysteine nucleosidase; Region: MTA/SAH-Nsdase; TIGR01704
195102000260	Dinucleotide-utilizing enzymes involved in molybdopterin and thiamine biosynthesis family 1 [Coenzyme metabolism]; Region: COG1179
195102000261	Family of activating enzymes (E1) of ubiquitin-like proteins related to the E.coli hypothetical protein ygdL. The common reaction mechanism catalyzed by E1-like enzymes begins with a nucleophilic attack of the C-terminal carboxylate of the ubiquitin-like...; Region: YgdL_like; cd00755
195102000262	putative ATP binding site [chemical binding]; other site
195102000263	putative substrate interface [chemical binding]; other site
195102000264	Fucose permease [Carbohydrate transport and metabolism]; Region: FucP; COG0738
195102000265	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
195102000266	putative substrate translocation pore; other site
195102000267	Acetyltransferases, including N-acetylases of ribosomal proteins [Translation, ribosomal structure and biogenesis]; Region: RimL; COG1670
195102000268	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl17182
195102000269	Deoxynucleoside kinases [Nucleotide transport and metabolism]; Region: COG1428
195102000270	Deoxyribonucleoside kinase (dNK) catalyzes the phosphorylation of deoxyribonucleosides to yield corresponding monophosphates (dNMPs). This family consists of various deoxynucleoside kinases including deoxyribo- cytidine (EC 2.7.1.74), guanosine (EC 2.7.1; Region: dNK; cd01673
195102000271	Substrate-binding site [chemical binding]; other site
195102000272	Substrate specificity [chemical binding]; other site
195102000273	transporter, basic amino acid/polyamine antiporter (APA) family; Region: 2A0302; TIGR00905
195102000274	Spore germination protein; Region: Spore_permease; cl17796
195102000275	glycogen branching enzyme; Provisional; Region: PRK12313
195102000276	N-terminal Early set domain associated with the catalytic domain of prokaryotic glycogen branching enzyme; Region: E_set_GBE_prok_N; cd02855
195102000277	Alpha amylase catalytic domain found in the Glycogen branching enzyme (also called 1,4-alpha-glucan branching enzyme); Region: AmyAc_Glg_BE; cd11322
195102000278	active site
195102000279	catalytic site [active]
195102000280	Alpha amylase, C-terminal all-beta domain; Region: Alpha-amylase_C; pfam02806
195102000281	This family is most closely related to the GT1 family of glycosyltransferases. Glycogen synthase catalyzes the formation and elongation of the alpha-1,4-glucose backbone using ADP-glucose, the second and key step of glycogen biosynthesis. This family...; Region: GT1_Glycogen_synthase_DULL1_like; cd03791
195102000282	glycogen synthase; Provisional; Region: glgA; PRK00654
195102000283	ADP-binding pocket [chemical binding]; other site
195102000284	homodimer interface [polypeptide binding]; other site
195102000285	This is a family of oligosaccharide phosphorylases. It includes yeast and mammalian glycogen phosphorylases, plant starch/glucan phosphorylase, as well as the maltodextrin phosphorylases of bacteria. The members of this family catalyze the breakdown of...; Region: GT1_Glycogen_Phosphorylase; cd04300
195102000286	homodimer interface [polypeptide binding]; other site
195102000287	glycogen/starch/alpha-glucan phosphorylases; Region: P_ylase; TIGR02093
195102000288	active site pocket [active]
195102000289	N-terminal Early set domain associated with the catalytic domain of cyclomaltodextrinase and pullulan-degrading enzymes; Region: E_set_CDase_PDE_N; cd02857
195102000290	homodimer interface [polypeptide binding]; other site
195102000291	maltodextrin glucosidase; Provisional; Region: PRK10785
195102000292	Alpha amylase catalytic domain found in cyclomaltodextrinases and related proteins; Region: AmyAc_CMD; cd11338
195102000293	active site
195102000294	homodimer interface [polypeptide binding]; other site
195102000295	catalytic site [active]
195102000296	glucose-1-phosphate adenylyltransferase; Provisional; Region: glgC; PRK05293
195102000297	ADP-glucose pyrophosphorylase is involved in the biosynthesis of glycogen or starch; Region: ADP_Glucose_PP; cd02508
195102000298	ligand binding site; other site
195102000299	oligomer interface; other site
195102000300	Glucose-1-phosphate adenylyltransferase, C-terminal Left-handed parallel beta helix (LbH) domain: Glucose-1-phosphate adenylyltransferase is also known as ADP-glucose synthase or ADP-glucose pyrophosphorylase. It catalyzes the first committed and...; Region: LbH_G1P_AT_C; cd04651
195102000301	dimer interface [polypeptide binding]; other site
195102000302	N-terminal domain interface [polypeptide binding]; other site
195102000303	sulfate 1 binding site; other site
195102000304	glucose-1-phosphate adenylyltransferase, GlgD subunit; Region: glgD; TIGR02092
195102000305	ADP-glucose pyrophosphorylase is involved in the biosynthesis of glycogen or starch; Region: ADP_Glucose_PP; cd02508
195102000306	ligand binding site; other site
195102000307	oligomer interface; other site
195102000308	Glucose-1-phosphate adenylyltransferase, C-terminal Left-handed parallel beta helix (LbH) domain: Glucose-1-phosphate adenylyltransferase is also known as ADP-glucose synthase or ADP-glucose pyrophosphorylase. It catalyzes the first committed and...; Region: LbH_G1P_AT_C; cd04651
195102000309	dimer interface [polypeptide binding]; other site
195102000310	N-terminal domain interface [polypeptide binding]; other site
195102000311	sulfate 1 binding site; other site
195102000312	Predicted integral membrane protein [Function unknown]; Region: COG5652
195102000313	cardiolipin synthase; Region: bac_cardiolipin; TIGR04265
195102000314	Catalytic domain, repeat 1, of bacterial cardiolipin synthase and similar proteins; Region: PLDc_CLS_1; cd09110
195102000315	putative active site [active]
195102000316	catalytic site [active]
195102000317	catalytic domain repeat 2 of bacterial cardiolipin synthase and similar proteins; Region: PLDc_CLS_2; cd09112
195102000318	putative active site [active]
195102000319	catalytic site [active]
195102000320	p-Aminobenzoyl-glutamate transporter family; Region: ydaH; TIGR00819
195102000321	Putative p-aminobenzoyl-glutamate transporter [Coenzyme metabolism]; Region: AbgT; COG2978
195102000322	CAT RNA binding domain; Region: CAT_RBD; smart01061
195102000323	PRD domain; Region: PRD; pfam00874
195102000324	PRD domain; Region: PRD; pfam00874
195102000325	Phosphotransferase system IIA components [Carbohydrate transport and metabolism]; Region: NagE; COG2190
195102000326	glycerol kinase (GK) interaction site [polypeptide binding]; other site
195102000327	HPr interaction site; other site
195102000328	active site
195102000329	phosphorylation site [posttranslational modification]
195102000330	Phosphotransferase system IIC components, glucose/maltose/N-acetylglucosamine-specific [Carbohydrate transport and metabolism]; Region: PtsG; COG1263
195102000331	PTS_IIB, PTS system, glucose/sucrose specific IIB subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIB_glc; cd00212
195102000332	active site turn [active]
195102000333	phosphorylation site [posttranslational modification]
195102000334	Transcriptional regulator [Transcription]; Region: AcrR; COG1309
195102000335	Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440
195102000336	Elongation factor G (EF-G) family; Region: EF-G_bact; cd04170
195102000337	elongation factor G; Reviewed; Region: PRK12740
195102000338	G1 box; other site
195102000339	putative GEF interaction site [polypeptide binding]; other site
195102000340	GTP/Mg2+ binding site [chemical binding]; other site
195102000341	Switch I region; other site
195102000342	G2 box; other site
195102000343	G3 box; other site
195102000344	Switch II region; other site
195102000345	G4 box; other site
195102000346	G5 box; other site
195102000347	EFG_mtEFG_II: this subfamily represents the domain II of elongation factor G (EF-G) in bacteria and, the C-terminus of mitochondrial Elongation factor G1 (mtEFG1) and G2 (mtEFG2)_like proteins found in eukaryotes. During the process of peptide synthesis...; Region: EFG_mtEFG_II; cd04088
195102000348	EFG_mtEFG1_IV: domains similar to domain IV of the bacterial translational elongation factor (EF) EF-G. Included in this group is a domain of mitochondrial Elongation factor G1 (mtEFG1) proteins homologous to domain IV of EF-G. Eukaryotic cells harbor 2...; Region: EFG_mtEFG1_IV; cd01434
195102000349	EFG_mtEFG_C: domains similar to the C-terminal domain of the bacterial translational elongation factor (EF) EF-G.  Included in this group is the C-terminus of mitochondrial Elongation factor G1 (mtEFG1) and G2 (mtEFG2) proteins. Eukaryotic cells harbor 2...; Region: EFG_mtEFG_C; cd03713
195102000350	Transcriptional regulator/sugar kinase [Transcription / Carbohydrate transport and metabolism]; Region: NagC; COG1940
195102000351	Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cd00012
195102000352	nucleotide binding site [chemical binding]; other site
195102000353	Rubredoxin, Small Modular nonheme iron binding domain containing a [Fe(SCys)4] center, present in rubrerythrin and nigerythrin and detected either N- or C-terminal to such proteins as flavin reductase, NAD(P)H-nitrite reductase, and...; Region: rubredoxin_SM; cd00729
195102000354	Rubredoxin; Region: Rubredoxin; pfam00301
195102000355	iron binding site [ion binding]; other site
195102000356	rubrerythrin-like, diiron-binding domain; Region: Rubrerythrin_like; cd01046
195102000357	Rubrerythrin [Energy production and conversion]; Region: COG1592
195102000358	diiron binding motif [ion binding]; other site
195102000359	Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067
195102000360	catalytic core [active]
195102000361	Transcriptional regulators of sugar metabolism [Transcription / Carbohydrate transport and metabolism]; Region: GlpR; COG1349
195102000362	DeoR-like helix-turn-helix domain; Region: HTH_DeoR; pfam08220
195102000363	DeoR C terminal sensor domain; Region: DeoRC; pfam00455
195102000364	Alcohol dehydrogenase, class IV [Energy production and conversion]; Region: EutG; COG1454
195102000365	Iron-containing alcohol dehydrogenases-like; Region: Fe-ADH6; cd08194
195102000366	putative active site [active]
195102000367	metal binding site [ion binding]; metal-binding site
195102000368	Tagatose-1,6-bisphosphate (TBP) aldolase and related Type B Class II aldolases. TBP aldolase is a tetrameric class II aldolase that catalyzes the reversible condensation of dihydroxyacetone phosphate with glyceraldehyde 3-phsophate to produce tagatose 1; Region: TBP_aldolase_IIB; cd00947
195102000369	intersubunit interface [polypeptide binding]; other site
195102000370	active site
195102000371	zinc binding site [ion binding]; other site
195102000372	Na+ binding site [ion binding]; other site
195102000373	Sugar kinases, ribokinase family [Carbohydrate transport and metabolism]; Region: RbsK; COG0524
195102000374	2-keto-3-deoxygluconate kinase (KdgK) phosphorylates 2-keto-3-deoxygluconate (KDG) to form 2-keto-3-deoxy-6-phosphogluconate (KDGP). KDG is the common intermediate product, that allows organisms to channel D-glucuronate and/or D-galacturinate into the...; Region: KdgK; cd01166
195102000375	substrate binding site [chemical binding]; other site
195102000376	ATP binding site [chemical binding]; other site
195102000377	KduI/IolB family; Region: KduI; pfam04962
195102000378	Acetolactate synthase [Amino acid transport and metabolism]; Region: COG3962
195102000379	Pyrimidine (PYR) binding domain of POX and related proteins; Region: TPP_PYR_POX_like; cd07035
195102000380	PYR/PP interface [polypeptide binding]; other site
195102000381	dimer interface [polypeptide binding]; other site
195102000382	TPP binding site [chemical binding]; other site
195102000383	Thiamine pyrophosphate enzyme, central domain; Region: TPP_enzyme_M; pfam00205
195102000384	Thiamine pyrophosphate (TPP) family, IolD subfamily, TPP-binding module; composed of proteins similar to Rhizobium leguminosarum bv. viciae IolD. IolD plays an important role in myo-inositol catabolism; Region: TPP_IolD; cd02003
195102000385	TPP-binding site; other site
195102000386	Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673
195102000387	Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408
195102000388	Oxidoreductase family, C-terminal alpha/beta domain; Region: GFO_IDH_MocA_C; pfam02894
195102000389	Sugar phosphate isomerases/epimerases [Carbohydrate transport and metabolism]; Region: IolE; COG1082
195102000390	AP endonuclease family 2; These endonucleases play a role in DNA repair. Cleave phosphodiester bonds at apurinic or apyrimidinic sites; the alignment also contains hexulose-6-phosphate isomerases, enzymes that catalyze the epimerization of...; Region: AP2Ec; cl12060
195102000391	putative transporter; Provisional; Region: PRK10484
195102000392	uncharacterized SLC5 subfamily, Escherichia coli YidK-like; solute binding domain; Region: SLC5sbd_YidK; cd10328
195102000393	Na binding site [ion binding]; other site
195102000394	Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673
195102000395	Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408
195102000396	Oxidoreductase family, C-terminal alpha/beta domain; Region: GFO_IDH_MocA_C; pfam02894
195102000397	Formate/nitrite transporter; Region: Form_Nir_trans; pfam01226
195102000398	3-hydroxybutyryl-CoA dehydratase; Validated; Region: PRK05809
195102000399	Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558
195102000400	substrate binding site [chemical binding]; other site
195102000401	oxyanion hole (OAH) forming residues; other site
195102000402	trimer interface [polypeptide binding]; other site
195102000403	Acyl CoA:acetate/3-ketoacid CoA transferase [Lipid metabolism]; Region: COG4670
195102000404	Coenzyme A transferase; Region: CoA_trans; smart00882
195102000405	Coenzyme A transferase; Region: CoA_trans; cl17247
195102000406	Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960
195102000407	Acyl-CoA dehydrogenase; Region: ACAD; cl09933
195102000408	active site
195102000409	Uncharacterized conserved protein [Function unknown]; Region: COG1416
195102000410	Glycerol dehydrogenase and related enzymes [Energy production and conversion]; Region: GldA; COG0371
195102000411	Glycerol dehydrogenases (GlyDH) catalyzes oxidation of glycerol to dihydroxyacetone in glycerol dissmilation; Region: GlyDH; cd08170
195102000412	dimer interface [polypeptide binding]; other site
195102000413	active site
195102000414	metal binding site [ion binding]; metal-binding site
195102000415	dihydroxyacetone kinase; Provisional; Region: PRK14479
195102000416	dihydroxyacetone kinase subunit DhaK; Provisional; Region: PRK14481
195102000417	DAK2 domain; Region: Dak2; pfam02734
195102000418	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
195102000419	Major Facilitator Superfamily; Region: MFS_1; pfam07690
195102000420	putative substrate translocation pore; other site
195102000421	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
195102000422	putative substrate translocation pore; other site
195102000423	L-lactate dehydrogenase; Reviewed; Region: ldh; PRK00066
195102000424	A subgroup of L-lactate dehydrogenases; Region: LDH_2; cd05292
195102000425	NAD binding site [chemical binding]; other site
195102000426	dimer interface [polypeptide binding]; other site
195102000427	substrate binding site [chemical binding]; other site
195102000428	tetramer (dimer of dimers) interface [polypeptide binding]; other site
195102000429	Protein of unknown function (DUF975); Region: DUF975; pfam06161
195102000430	Protein of unknown function (DUF975); Region: DUF975; pfam06161
195102000431	[FeFe] hydrogenase H-cluster maturation GTPase HydF; Region: GTP_HydF; TIGR03918
195102000432	E. coli Ras-like protein (Era)-like GTPase; Region: Era_like; cd00880
195102000433	G1 box; other site
195102000434	GTP/Mg2+ binding site [chemical binding]; other site
195102000435	Switch I region; other site
195102000436	G2 box; other site
195102000437	Switch II region; other site
195102000438	G3 box; other site
195102000439	G4 box; other site
195102000440	G5 box; other site
195102000441	thiamine biosynthesis protein ThiH; Reviewed; Region: thiH; PRK09613
195102000442	Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335
195102000443	FeS/SAM binding site; other site
195102000444	Biotin and Thiamin Synthesis associated domain; Region: BATS; smart00876
195102000445	putative iron-only hydrogenase system regulator; Region: hyd_TM1266; TIGR03959
195102000446	Predicted secreted protein [Function unknown]; Region: COG4086
195102000447	Protein of unknown function (DUF1002); Region: DUF1002; pfam06207
195102000448	Protein of unknown function (DUF1659); Region: DUF1659; pfam07872
195102000449	Protein of unknown function (DUF2922); Region: DUF2922; pfam11148
195102000450	N-acetylmuramoyl-L-alanine amidase [Cell envelope biogenesis, outer membrane]; Region: AmiC; COG0860
195102000451	N-acetylmuramoyl-L-alanine amidase or MurNAc-LAA (also known as peptidoglycan aminohydrolase, NAMLA amidase, NAMLAA, Amidase 3, and peptidoglycan amidase; EC 3.5.1.28) is an autolysin that hydrolyzes the amide bond between N-acetylmuramoyl and L-amino...; Region: MurNAc-LAA; cd02696
195102000452	active site
195102000453	metal binding site [ion binding]; metal-binding site
195102000454	zinc-ribbon domain; Region: zinc_ribbon_2; pfam13240
195102000455	Double zinc ribbon; Region: DZR; pfam12773
195102000456	YARHG domain; Region: YARHG; pfam13308
195102000457	Double zinc ribbon; Region: DZR; pfam12773
195102000458	Predicted membrane protein [Function unknown]; Region: COG4640
195102000459	zinc-ribbon domain; Region: zinc_ribbon_2; pfam13240
195102000460	Double zinc ribbon; Region: DZR; pfam12773
195102000461	phosphate regulon transcriptional regulatory protein PhoB; Region: PhoB; TIGR02154
195102000462	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
195102000463	active site
195102000464	phosphorylation site [posttranslational modification]
195102000465	intermolecular recognition site; other site
195102000466	dimerization interface [polypeptide binding]; other site
195102000467	Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383
195102000468	DNA binding site [nucleotide binding]
195102000469	Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642
195102000470	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
195102000471	ATP binding site [chemical binding]; other site
195102000472	Mg2+ binding site [ion binding]; other site
195102000473	G-X-G motif; other site
195102000474	ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136
195102000475	ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255
195102000476	Walker A/P-loop; other site
195102000477	ATP binding site [chemical binding]; other site
195102000478	Q-loop/lid; other site
195102000479	ABC transporter signature motif; other site
195102000480	Walker B; other site
195102000481	D-loop; other site
195102000482	H-loop/switch region; other site
195102000483	FtsX-like permease family; Region: FtsX; pfam02687
195102000484	Colicin immunity protein / pyocin immunity protein; Region: Colicin_Pyocin; pfam01320
195102000485	The Tellurite-resistance/Dicarboxylate Transporter (TDT) family; Region: TDT; cl04176
195102000486	The Tellurite-resistance/Dicarboxylate Transporter (TDT) family; Region: TDT; cl04176
195102000487	gating phenylalanine in ion channel; other site
195102000488	Predicted membrane protein [Function unknown]; Region: COG2855
195102000489	Permeases of the drug/metabolite transporter (DMT) superfamily [Carbohydrate transport and metabolism / Amino acid transport and metabolism / General function prediction only]; Region: RhaT; COG0697
195102000490	EamA-like transporter family; Region: EamA; cl17759
195102000491	EamA-like transporter family; Region: EamA; cl17759
195102000492	competence damage-inducible protein A; Provisional; Region: PRK00549
195102000493	Competence-damaged protein. CinA is the first gene in the competence- inducible (cin) operon and is thought to be specifically required at some stage in the process of transformation. This domain is closely related to a domain, found in a variety of...; Region: cinA; cd00885
195102000494	putative MPT binding site; other site
195102000495	Uncharacterized protein (competence- and mitomycin-induced) [General function prediction only]; Region: CinA; COG1546
195102000496	CAAX protease self-immunity; Region: Abi; pfam02517
195102000497	Rubrerythrin [Energy production and conversion]; Region: COG1592
195102000498	Rubrerythrin, ferritin-like diiron-binding domain; Region: Rubrerythrin; cd01041
195102000499	binuclear metal center [ion binding]; other site
195102000500	Rubredoxin, Small Modular nonheme iron binding domain containing a [Fe(SCys)4] center, present in rubrerythrin and nigerythrin and detected either N- or C-terminal to such proteins as flavin reductase, NAD(P)H-nitrite reductase, and...; Region: rubredoxin_SM; cd00729
195102000501	iron binding site [ion binding]; other site
195102000502	2'-5' RNA ligase superfamily; Region: 2_5_RNA_ligase2; pfam13563
195102000503	ATPase components of ABC transporters with duplicated ATPase domains [General function prediction only]; Region: Uup; COG0488
195102000504	ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221
195102000505	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
195102000506	Walker A/P-loop; other site
195102000507	ATP binding site [chemical binding]; other site
195102000508	Q-loop/lid; other site
195102000509	ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221
195102000510	ABC transporter signature motif; other site
195102000511	Walker B; other site
195102000512	D-loop; other site
195102000513	ABC transporter; Region: ABC_tran_2; pfam12848
195102000514	ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221
195102000515	Short C-terminal domain; Region: SHOCT; pfam09851
195102000516	Transposase IS200 like; Region: Y1_Tnp; pfam01797
195102000517	Nuclease-related domain; Region: NERD; pfam08378
195102000518	Superfamily I DNA and RNA helicases [General function prediction only]; Region: COG3972
195102000519	Family description; Region: UvrD_C_2; pfam13538
195102000520	Ribbon-helix-helix domain; Region: RHH_3; pfam12651
195102000521	BRO family, N-terminal domain; Region: Bro-N; cl10591
195102000522	BRO family, N-terminal domain; Region: Bro-N; cl10591
195102000523	RNA 2'-phosphotransferase; Reviewed; Region: PRK00819
195102000524	RNA:NAD 2'-phosphotransferase [Translation, ribosomal structure and biogenesis]; Region: KptA; COG1859
195102000525	haloacid dehalogenase-like hydrolase; Region: Hydrolase; pfam00702
195102000526	Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427
195102000527	motif II; other site
195102000528	2-keto-3-deoxygluconate kinase (KdgK) phosphorylates 2-keto-3-deoxygluconate (KDG) to form 2-keto-3-deoxy-6-phosphogluconate (KDGP). KDG is the common intermediate product, that allows organisms to channel D-glucuronate and/or D-galacturinate into the...; Region: KdgK; cd01166
195102000529	Sugar kinases, ribokinase family [Carbohydrate transport and metabolism]; Region: RbsK; COG0524
195102000530	substrate binding site [chemical binding]; other site
195102000531	ATP binding site [chemical binding]; other site
195102000532	beta-D-glucuronidase; Provisional; Region: PRK10150
195102000533	Glycosyl hydrolases family 2, sugar binding domain; Region: Glyco_hydro_2_N; pfam02837
195102000534	Glycosyl hydrolases family 2; Region: Glyco_hydro_2; pfam00703
195102000535	Glycosyl hydrolases family 2, TIM barrel domain; Region: Glyco_hydro_2_C; pfam02836
195102000536	Transcriptional regulators [Transcription]; Region: GntR; COG1802
195102000537	Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377
195102000538	DNA-binding site [nucleotide binding]; DNA binding site
195102000539	This entry represents the C-terminal ligand binding domain of many members of the GntR family; Region: FCD; smart00895
195102000540	D-mannonate oxidoreductase; Provisional; Region: PRK08277
195102000541	putative D-mannonate oxidoreductase, classical (c) SDR; Region: mannonate_red_SDR_c; cd08935
195102000542	putative NAD(P) binding site [chemical binding]; other site
195102000543	active site
195102000544	2-keto-3-deoxy-6-phosphogluconate aldolase [Carbohydrate transport and metabolism]; Region: Eda; COG0800
195102000545	KDPG and KHG aldolase; Region: KDPG_aldolase; cd00452
195102000546	active site
195102000547	intersubunit interface [polypeptide binding]; other site
195102000548	catalytic residue [active]
195102000549	mannonate dehydratase; Provisional; Region: PRK03906
195102000550	mannonate dehydratase; Region: uxuA; TIGR00695
195102000551	glucuronate isomerase; Reviewed; Region: PRK02925
195102000552	Glucuronate isomerase [Carbohydrate transport and metabolism]; Region: UxaC; COG1904
195102000553	melibiose:sodium symporter; Provisional; Region: PRK10429; cl15392
195102000554	MFS/sugar transport protein; Region: MFS_2; pfam13347
195102000555	Beta-glucosidase-related glycosidases [Carbohydrate transport and metabolism]; Region: BglX; COG1472
195102000556	Glycosyl hydrolase family 3 N terminal domain; Region: Glyco_hydro_3; cl07971
195102000557	Cna protein B-type domain; Region: Cna_B; pfam05738
195102000558	Cna protein B-type domain; Region: Cna_B; pfam05738
195102000559	fimbrial isopeptide formation D2 domain; Region: RrgB_K2N_iso_D2; TIGR04226
195102000560	Cna protein B-type domain; Region: Cna_B; pfam05738
195102000561	Sortase C (SrtC) or subfamily-3 sortases are membrane cysteine transpeptidases found in Gram-positive bacteria that anchor surface proteins to peptidoglycans of the bacterial cell wall envelope. This involves a transpeptidation reaction in which the...; Region: Sortase_C_3; cd05827
195102000562	active site
195102000563	catalytic site [active]
195102000564	Domain of unknown function (DUF2935); Region: DUF2935; pfam11155
195102000565	Domain of unknown function (DUF2935); Region: DUF2935; pfam11155
195102000566	Uncharacterized conserved protein [Function unknown]; Region: COG0398
195102000567	SNARE associated Golgi protein; Region: SNARE_assoc; pfam09335
195102000568	conserved hypothetical protein, ribA/ribD-fused; Region: ribofla_fusion; TIGR02464
195102000569	Mga helix-turn-helix domain; Region: Mga; pfam05043
195102000570	Phosphotransferase system, EIIC; Region: PTS_EIIC_2; pfam13303
195102000571	Phosphotransferase system, fructose-specific IIC component [Carbohydrate transport and metabolism]; Region: FruA; cl17425
195102000572	Thiol-activated cytolysin; Region: Thiol_cytolysin; pfam01289
195102000573	putative septicolysin, cholesterol-dependent cytolysin family and related proteins; Region: septicolysin_like; cd12208
195102000574	oligomer interface [polypeptide binding]; other site
195102000575	inner membrane transporter YjeM; Provisional; Region: PRK15238
195102000576	Beta-galactosidase [Carbohydrate transport and metabolism]; Region: LacA; COG1874
195102000577	Beta-galactosidase; Region: Glyco_hydro_42; pfam02449
195102000578	A4 beta-galactosidase middle domain: a type 1 glutamine amidotransferase (GATase1)-like domain; Region: A4_beta-galactosidase_middle_domain; cd03143
195102000579	Beta-galactosidase C-terminal domain; Region: Glyco_hydro_42C; pfam08533
195102000580	arginine deiminase; Provisional; Region: PRK01388
195102000581	ornithine carbamoyltransferase; Provisional; Region: PRK04284
195102000582	Aspartate/ornithine carbamoyltransferase, carbamoyl-P binding domain; Region: OTCace_N; pfam02729
195102000583	Aspartate/ornithine carbamoyltransferase, Asp/Orn binding domain; Region: OTCace; pfam00185
195102000584	transporter, basic amino acid/polyamine antiporter (APA) family; Region: 2A0302; TIGR00905
195102000585	Spore germination protein; Region: Spore_permease; cl17796
195102000586	carbamate kinase; Reviewed; Region: PRK12686
195102000587	AAK_CK: Carbamate kinase (CK) catalyzes both the ATP-phosphorylation of carbamate and carbamoyl phosphate (CP) utilization with the production of ATP from ADP and CP. Both CK (this CD) and nonhomologous CP synthetase synthesize carbamoyl phosphate, an...; Region: AAK_CK; cd04235
195102000588	putative substrate binding site [chemical binding]; other site
195102000589	nucleotide binding site [chemical binding]; other site
195102000590	nucleotide binding site [chemical binding]; other site
195102000591	homodimer interface [polypeptide binding]; other site
195102000592	Arginine repressor, DNA binding domain; Region: Arg_repressor; pfam01316
195102000593	Arginine repressor [Transcription]; Region: ArgR; COG1438
195102000594	Arginine repressor, C-terminal domain; Region: Arg_repressor_C; pfam02863
195102000595	Peptidase family M9 N-terminal; Region: Peptidase_M9_N; pfam08453
195102000596	Collagenase; Region: Peptidase_M9; pfam01752
195102000597	polycystic kidney disease I (PKD) domain; similar to other cell-surface modules, with an IG-like fold; domain probably functions as a ligand binding site in protein-protein or protein-carbohydrate interactions; a single instance of the repeat is...; Region: PKD; cd00146
195102000598	Bacterial pre-peptidase C-terminal domain; Region: PPC; pfam04151
195102000599	Bacterial pre-peptidase C-terminal domain; Region: PPC; pfam04151
195102000600	large-conductance mechanosensitive channel; Reviewed; Region: mscL; PRK00567
195102000601	large-conductance mechanosensitive channel; Provisional; Region: mscL; PRK13952
195102000602	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
195102000603	S-adenosylmethionine binding site [chemical binding]; other site
195102000604	cystathionine beta-lyase; Provisional; Region: PRK07671
195102000605	CGS_like: Cystathionine gamma-synthase is a PLP dependent enzyme and catalyzes the committed step of methionine biosynthesis. This pathway is unique to microorganisms and plants, rendering the enzyme an attractive target for the development of...; Region: CGS_like; cd00614
195102000606	homodimer interface [polypeptide binding]; other site
195102000607	substrate-cofactor binding pocket; other site
195102000608	pyridoxal 5'-phosphate binding site [chemical binding]; other site
195102000609	catalytic residue [active]
195102000610	Cysteine synthase [Amino acid transport and metabolism]; Region: CysK; COG0031
195102000611	CBS_like: This subgroup includes Cystathionine beta-synthase (CBS) and Cysteine synthase. CBS is a unique heme-containing enzyme that catalyzes a pyridoxal 5'-phosphate (PLP)-dependent condensation of serine and homocysteine to give cystathionine; Region: CBS_like; cd01561
195102000612	dimer interface [polypeptide binding]; other site
195102000613	pyridoxal 5'-phosphate binding site [chemical binding]; other site
195102000614	catalytic residue [active]
195102000615	S-ribosylhomocysteinase; Provisional; Region: PRK02260
195102000616	Esterases and lipases (includes fungal lipases, cholinesterases, etc.)  These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cd00312
195102000617	alpha/beta hydrolase fold; Region: Abhydrolase_3; pfam07859
195102000618	substrate binding pocket [chemical binding]; other site
195102000619	Prolyl oligopeptidase family; Region: Peptidase_S9; pfam00326
195102000620	ABC-type uncharacterized transport system, permease component [General function prediction only]; Region: COG4587
195102000621	ABC-2 family transporter protein; Region: ABC2_membrane_6; pfam06182
195102000622	ABC-type uncharacterized transport system, permease component [General function prediction only]; Region: COG4587
195102000623	ABC-2 family transporter protein; Region: ABC2_membrane_6; pfam06182
195102000624	ABC-type multidrug transport system, ATPase component [Defense mechanisms]; Region: CcmA; COG1131
195102000625	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
195102000626	Walker A/P-loop; other site
195102000627	ATP binding site [chemical binding]; other site
195102000628	Q-loop/lid; other site
195102000629	ABC transporter signature motif; other site
195102000630	Walker B; other site
195102000631	D-loop; other site
195102000632	H-loop/switch region; other site
195102000633	Domain of unknown function (DUF4162); Region: DUF4162; pfam13732
195102000634	NAD(P)H:FMN oxidoreductase family. This domain catalyzes the reduction of flavin, nitrocompound, quinones and azo compounds using NADH or NADPH as an electron donor. The enzyme is a homodimer, and each monomer binds a FMN as co-factor. This family...; Region: NfsB_like_nitroreductase; cd02149
195102000635	dimer interface [polypeptide binding]; other site
195102000636	FMN binding site [chemical binding]; other site
195102000637	N-acetylmannosamine-6-phosphate epimerase (NanE) converts N-acetylmannosamine-6-phosphate to N-acetylglucosamine-6-phosphate. This reaction is part of the pathway that allows the usage of sialic acid as a carbohydrate source. Sialic acids are a family of...; Region: NanE; cd04729
195102000638	N-acetylmannosamine-6-phosphate 2-epimerase; Provisional; Region: PRK01130
195102000639	putative active site cavity [active]
195102000640	N-acetylneuraminate lyase; Provisional; Region: PRK04147
195102000641	N-Acetylneuraminic acid aldolase, also called N-acetylneuraminate lyase (NAL); Region: NAL; cd00954
195102000642	inhibitor site; inhibition site
195102000643	active site
195102000644	dimer interface [polypeptide binding]; other site
195102000645	catalytic residue [active]
195102000646	uncharacterized subgroup of the Na(+)/iodide (NIS) cotransporter subfamily; putative solute-binding domain; Region: SLC5sbd_NIS-like_u3; cd11495
195102000647	Na binding site [ion binding]; other site
195102000648	Domain of unknown function (DUF386); Region: DUF386; cl01047
195102000649	Transcriptional regulator/sugar kinase [Transcription / Carbohydrate transport and metabolism]; Region: NagC; COG1940
195102000650	Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cd00012
195102000651	nucleotide binding site [chemical binding]; other site
195102000652	Transcriptional regulators [Transcription]; Region: RpiR; COG1737
195102000653	Helix-turn-helix domain, rpiR family; Region: HTH_6; pfam01418
195102000654	RpiR-like protein. RpiR contains a SIS (Sugar ISomerase) domain, which is found in many phosphosugar isomerases and phosphosugar binding proteins. In E. coli, rpiR negatively regulates the expression of rpiB gene. Both rpiB and rpiA are ribose phosphate...; Region: SIS_RpiR; cd05013
195102000655	putative active site [active]
195102000656	beta-N-acetylglucosaminidase; Region: NAGidase; pfam07555
195102000657	F5/8 type C domain; Region: F5_F8_type_C; pfam00754
195102000658	Coagulation factor 5/8 C-terminal domain, discoidin domain; Cell surface-attached carbohydrate-binding domain, present in eukaryotes and assumed to have horizontally transferred to eubacterial genomes; Region: FA58C; cd00057
195102000659	Coagulation factor 5/8 C-terminal domain, discoidin domain; Region: FA58C; smart00231
195102000660	sugar binding site [chemical binding]; other site
195102000661	F5/8 type C domain; Region: F5_F8_type_C; pfam00754
195102000662	cobalt transport protein CbiM; Validated; Region: PRK08319
195102000663	Cobalt uptake substrate-specific transmembrane region; Region: CbiM; pfam01891
195102000664	cobalt transport protein CbiN; Provisional; Region: PRK02898
195102000665	cobalt ABC transporter, permease protein CbiQ; Region: CbiQ_TIGR; TIGR02454
195102000666	cobalt transporter ATP-binding subunit; Provisional; Region: cbiO; PRK13636
195102000667	First domain of the ATP-binding cassette component of cobalt transport system; Region: ABC_cobalt_CbiO_domain1; cd03225
195102000668	Walker A/P-loop; other site
195102000669	ATP binding site [chemical binding]; other site
195102000670	Q-loop/lid; other site
195102000671	ABC transporter signature motif; other site
195102000672	Walker B; other site
195102000673	D-loop; other site
195102000674	H-loop/switch region; other site
195102000675	PTS system, alpha-glucoside-specific IIBC component; Region: PTS-IIBC-alpha; TIGR02005
195102000676	Phosphotransferase system IIC components, glucose/maltose/N-acetylglucosamine-specific [Carbohydrate transport and metabolism]; Region: PtsG; COG1263
195102000677	PTS_IIB, PTS system, glucose/sucrose specific IIB subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIB_glc; cd00212
195102000678	active site turn [active]
195102000679	phosphorylation site [posttranslational modification]
195102000680	Transcriptional regulators [Transcription]; Region: RpiR; COG1737
195102000681	Helix-turn-helix domain, rpiR family; Region: HTH_6; pfam01418
195102000682	RpiR-like protein. RpiR contains a SIS (Sugar ISomerase) domain, which is found in many phosphosugar isomerases and phosphosugar binding proteins. In E. coli, rpiR negatively regulates the expression of rpiB gene. Both rpiB and rpiA are ribose phosphate...; Region: SIS_RpiR; cd05013
195102000683	putative active site [active]
195102000684	Transcriptional regulators [Transcription]; Region: RpiR; COG1737
195102000685	RpiR-like protein. RpiR contains a SIS (Sugar ISomerase) domain, which is found in many phosphosugar isomerases and phosphosugar binding proteins. In E. coli, rpiR negatively regulates the expression of rpiB gene. Both rpiB and rpiA are ribose phosphate...; Region: SIS_RpiR; cd05013
195102000686	putative active site [active]
195102000687	Alpha-galactosidases/6-phospho-beta-glucosidases, family 4 of glycosyl hydrolases [Carbohydrate transport and metabolism]; Region: CelF; COG1486
195102000688	Glycoside Hydrolases Family 4; GlvA- and pagL-like glycosidases; Region: GH4_GlvA_pagL_like; cd05298
195102000689	NAD binding site [chemical binding]; other site
195102000690	sugar binding site [chemical binding]; other site
195102000691	divalent metal binding site [ion binding]; other site
195102000692	putative tetramer (dimer of dimers) interface [polypeptide binding]; other site
195102000693	dimer interface [polypeptide binding]; other site
195102000694	HAD superfamily, subfamily IIIB (Acid phosphatase); Region: Acid_phosphat_B; cl17236
195102000695	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3883
195102000696	Membrane proteins related to metalloendopeptidases [Cell envelope biogenesis, outer membrane]; Region: NlpD; COG0739
195102000697	Peptidase family M23; Region: Peptidase_M23; pfam01551
195102000698	Left-handed parallel beta-Helix (LbetaH or LbH) domain: The alignment contains 5 turns, each containing three imperfect tandem repeats of a hexapeptide repeat motif (X-[STAV]-X-[LIV]-[GAED]-X). Proteins containing hexapeptide repeats are often enzymes...; Region: LbetaH; cl00160
195102000699	sugar O-acyltransferase, sialic acid O-acetyltransferase NeuD family; Region: NeuD_NnaD; TIGR03570
195102000700	putative trimer interface [polypeptide binding]; other site
195102000701	putative CoA binding site [chemical binding]; other site
195102000702	Uncharacterized family 2; belongs to a superfamily containing transcriptional regulators CsoR (copper-sensitive operon repressor), RcnR, and FrmR, and related domains; this family was previously known as part of DUF156; Region: CsoR-like_DUF156_2; cd10159
195102000703	putative homodimer interface [polypeptide binding]; other site
195102000704	putative homotetramer interface [polypeptide binding]; other site
195102000705	putative allosteric switch controlling residues; other site
195102000706	putative metal binding site [ion binding]; other site
195102000707	putative homodimer-homodimer interface [polypeptide binding]; other site
195102000708	phosphate regulon sensor kinase PhoR; Region: phoR_proteo; TIGR02966
195102000709	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
195102000710	putative active site [active]
195102000711	heme pocket [chemical binding]; other site
195102000712	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
195102000713	dimer interface [polypeptide binding]; other site
195102000714	phosphorylation site [posttranslational modification]
195102000715	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
195102000716	ATP binding site [chemical binding]; other site
195102000717	Mg2+ binding site [ion binding]; other site
195102000718	G-X-G motif; other site
195102000719	Fucose 4-O-acetylase and related acetyltransferases [Carbohydrate transport and metabolism]; Region: NolL; COG3594
195102000720	Acyltransferase family; Region: Acyl_transf_3; pfam01757
195102000721	Conserved TM helix; Region: TM_helix; pfam05552
195102000722	Mechanosensitive ion channel; Region: MS_channel; pfam00924
195102000723	Heme oxygenase catalyzes the rate limiting step in the degradation of heme to bilirubin, it is essential for recycling of iron from heme. Heme is used as a substrate and cofactor for its own degradation to biliverdin, iron, and carbon monoxide. This...; Region: HemeO; cd00232
195102000724	heme binding pocket [chemical binding]; other site
195102000725	heme ligand [chemical binding]; other site
195102000726	DNA repair exonuclease [DNA replication, recombination, and repair]; Region: SbcD; COG0420
195102000727	Mre11 nuclease, N-terminal metallophosphatase domain; Region: MPP_Mre11_N; cd00840
195102000728	active site
195102000729	metal binding site [ion binding]; metal-binding site
195102000730	DNA binding site [nucleotide binding]
195102000731	Type 5 capsule protein repressor C-terminal domain; Region: SbcD_C; pfam12320
195102000732	ATPase involved in DNA repair [DNA replication, recombination, and repair]; Region: SbcC; COG0419
195102000733	ATP-binding cassette domain of sbcCD; Region: ABC_sbcCD; cd03279
195102000734	Walker A/P-loop; other site
195102000735	ATP binding site [chemical binding]; other site
195102000736	Q-loop/lid; other site
195102000737	ATPase involved in DNA repair [DNA replication, recombination, and repair]; Region: SbcC; COG0419
195102000738	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
195102000739	ABC transporter signature motif; other site
195102000740	Walker B; other site
195102000741	D-loop; other site
195102000742	H-loop/switch region; other site
195102000743	acetate kinase A/propionate kinase 2; Reviewed; Region: PRK00180
195102000744	propionate/acetate kinase; Provisional; Region: PRK12379
195102000745	tellurium resistance terB-like protein; Region: terB_like; cd07177
195102000746	metal binding site [ion binding]; metal-binding site
195102000747	DnaJ-class molecular chaperone with C-terminal Zn finger domain [Posttranslational modification, protein turnover, chaperones]; Region: DnaJ; COG0484
195102000748	DnaJ domain or J-domain.  DnaJ/Hsp40 (heat shock protein 40) proteins are highly conserved and play crucial roles in protein translation, folding, unfolding, translocation, and degradation. They act primarily by stimulating the ATPase activity of Hsp70s; Region: DnaJ; cd06257
195102000749	HSP70 interaction site [polypeptide binding]; other site
195102000750	helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342
195102000751	Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165
195102000752	NEAr Transporter domain; Region: NEAT; smart00725
195102000753	heme-binding site [chemical binding]; other site
195102000754	NEAr Transport domain, a component of cell surface proteins; Region: NEAT; cd06920
195102000755	heme-binding site [chemical binding]; other site
195102000756	NEAr Transport domain, a component of cell surface proteins; Region: NEAT; cd06920
195102000757	heme-binding site [chemical binding]; other site
195102000758	NEAr Transport domain, a component of cell surface proteins; Region: NEAT; cd06920
195102000759	heme-binding site [chemical binding]; other site
195102000760	NEAr Transport domain, a component of cell surface proteins; Region: NEAT; cd06920
195102000761	heme-binding site [chemical binding]; other site
195102000762	Sortase D (SrtD) is a membrane transpeptidase found in gram-positive bacteria that anchors surface proteins to peptidoglycans of the bacterial cell wall envelope. This involves a transpeptidation reaction in which the surface protein substrate is cleaved...; Region: Sortase_D_5; cd06166
195102000763	active site
195102000764	catalytic site [active]
195102000765	heme ABC transporter, heme-binding protein isdE; Region: IsdE; TIGR03659
195102000766	Siderophore binding protein FatB.  These proteins have been shown to function as ABC-type initial receptors in the siderophore-mediated iron uptake in some eubacterial species.  They belong to the TroA superfamily of periplasmic metal binding proteins...; Region: FatB; cd01140
195102000767	putative ligand binding residues [chemical binding]; other site
195102000768	iron-hydroxamate transporter permease subunit; Provisional; Region: PRK10577
195102000769	Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550
195102000770	ABC-ATPase subunit  interface; other site
195102000771	dimer interface [polypeptide binding]; other site
195102000772	putative PBP binding regions; other site
195102000773	ABC-type cobalamin/Fe3+-siderophores transport systems, ATPase components [Inorganic ion transport and metabolism / Coenzyme metabolism]; Region: FepC; COG1120
195102000774	ATP-binding component of iron-siderophores, vitamin B12 and hemin transporters and related proteins; Region: ABC_Iron-Siderophores_B12_Hemin; cd03214
195102000775	Walker A/P-loop; other site
195102000776	ATP binding site [chemical binding]; other site
195102000777	Q-loop/lid; other site
195102000778	ABC transporter signature motif; other site
195102000779	Walker B; other site
195102000780	D-loop; other site
195102000781	H-loop/switch region; other site
195102000782	ABC-type transport system involved in cytochrome bd biosynthesis, ATPase and permease components [Energy production and conversion / Posttranslational modification, protein turnover, chaperones]; Region: CydD; COG4988
195102000783	ABC transporter transmembrane region; Region: ABC_membrane; pfam00664
195102000784	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
195102000785	Walker A/P-loop; other site
195102000786	ATP binding site [chemical binding]; other site
195102000787	Q-loop/lid; other site
195102000788	ABC transporter signature motif; other site
195102000789	Walker B; other site
195102000790	D-loop; other site
195102000791	H-loop/switch region; other site
195102000792	ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132
195102000793	ABC transporter transmembrane region; Region: ABC_membrane; pfam00664
195102000794	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
195102000795	Walker A/P-loop; other site
195102000796	ATP binding site [chemical binding]; other site
195102000797	Q-loop/lid; other site
195102000798	ABC transporter signature motif; other site
195102000799	Walker B; other site
195102000800	D-loop; other site
195102000801	H-loop/switch region; other site
195102000802	Protein of unknown function (DUF454); Region: DUF454; cl01063
195102000803	hypothetical protein; Provisional; Region: PRK10410
195102000804	BFD-like [2Fe-2S] binding domain; Region: Fer2_BFD; pfam04324
195102000805	arylsulfatase; Provisional; Region: PRK13759
195102000806	Arylsulfatase A and related enzymes [Inorganic ion transport and metabolism]; Region: AslA; COG3119
195102000807	Sugar phosphate permease [Carbohydrate transport and metabolism]; Region: UhpC; COG2271
195102000808	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
195102000809	putative substrate translocation pore; other site
195102000810	Bacterial extracellular solute-binding protein; Region: SBP_bac_11; pfam13531
195102000811	ABC-type Fe3+ transport system, periplasmic component [Inorganic ion transport and metabolism]; Region: AfuA; COG1840
195102000812	Protein of unknown function (DUF3919); Region: DUF3919; pfam13057
195102000813	Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642
195102000814	Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225
195102000815	dimerization interface [polypeptide binding]; other site
195102000816	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
195102000817	dimer interface [polypeptide binding]; other site
195102000818	phosphorylation site [posttranslational modification]
195102000819	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
195102000820	ATP binding site [chemical binding]; other site
195102000821	Mg2+ binding site [ion binding]; other site
195102000822	G-X-G motif; other site
195102000823	Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745
195102000824	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
195102000825	active site
195102000826	phosphorylation site [posttranslational modification]
195102000827	intermolecular recognition site; other site
195102000828	dimerization interface [polypeptide binding]; other site
195102000829	Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383
195102000830	DNA binding site [nucleotide binding]
195102000831	Kef-type K+ transport systems, membrane components [Inorganic ion transport and metabolism]; Region: KefB; COG0475
195102000832	Sodium/hydrogen exchanger family; Region: Na_H_Exchanger; pfam00999
195102000833	Adhesin lipoprotein; Region: Lipoprotein_7; pfam01540
195102000834	Peptidoglycan binding domains similar to the C-terminal domain of outer-membrane protein OmpA; Region: OmpA_C-like; cl02931
195102000835	ligand binding site [chemical binding]; other site
195102000836	Enterocin A Immunity; Region: EntA_Immun; pfam08951
195102000837	CAAX protease self-immunity; Region: Abi; pfam02517
195102000838	Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949
195102000839	metal binding site [ion binding]; metal-binding site
195102000840	active site
195102000841	I-site; other site
195102000842	EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2).  The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948
195102000843	DnaJ domain or J-domain.  DnaJ/Hsp40 (heat shock protein 40) proteins are highly conserved and play crucial roles in protein translation, folding, unfolding, translocation, and degradation. They act primarily by stimulating the ATPase activity of Hsp70s; Region: DnaJ; cl02542
195102000844	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
195102000845	binding surface
195102000846	Tetratricopeptide repeat; Region: TPR_16; pfam13432
195102000847	TPR motif; other site
195102000848	GrpE is the adenine nucleotide exchange factor of DnaK (Hsp70)-type ATPases. The GrpE dimer binds to the ATPase domain of Hsp70 catalyzing the dissociation of ADP, which enables rebinding of ATP, one step in the Hsp70 reaction cycle in protein folding; Region: GrpE; cd00446
195102000849	hsp70 (ATPase domain) interactions [polypeptide binding]; other site
195102000850	molecular chaperone DnaK; Provisional; Region: dnaK; PRK00290
195102000851	Nucleotide-binding domain of the HSP70 family; Region: HSP70_NBD; cd10170
195102000852	nucleotide binding site [chemical binding]; other site
195102000853	putative NEF/HSP70 interaction site [polypeptide binding]; other site
195102000854	SBD interface [polypeptide binding]; other site
195102000855	Capsular polysaccharide biosynthesis protein [Carbohydrate transport and metabolism / Cell envelope biogenesis, outer membrane]; Region: CapC; COG4464
195102000856	Coat F domain; Region: Coat_F; pfam07875
195102000857	Protein of unknown function (DUF1648); Region: DUF1648; pfam07853
195102000858	NAD-dependent deacetylase; Provisional; Region: PRK00481
195102000859	SIR2H: Uncharacterized prokaryotic Sir2 homologs from several gram positive bacterial species and Fusobacteria; and are members of the SIR2 family of proteins, silent information regulator 2 (Sir2) enzymes which catalyze NAD+-dependent protein/histone...; Region: SIR2H; cd01411
195102000860	NAD+ binding site [chemical binding]; other site
195102000861	substrate binding site [chemical binding]; other site
195102000862	putative Zn binding site [ion binding]; other site
195102000863	Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093
195102000864	non-specific DNA binding site [nucleotide binding]; other site
195102000865	salt bridge; other site
195102000866	sequence-specific DNA binding site [nucleotide binding]; other site
195102000867	CarD-like/TRCF domain; Region: CarD_TRCF; smart01058
195102000868	Small-conductance mechanosensitive channel [Cell envelope biogenesis, outer membrane]; Region: MscS; COG0668
195102000869	Mechanosensitive ion channel; Region: MS_channel; pfam00924
195102000870	Uncharacterized protein involved in copper resistance [Inorganic ion transport and metabolism]; Region: CutC; COG3142
195102000871	Protein of unknown function (DUF1576); Region: DUF1576; pfam07613
195102000872	Protein of unknown function (DUF1576); Region: DUF1576; pfam07613
195102000873	Family 1 of Uracil-DNA glycosylase (UDG) enzymes; Region: UDG_F1; cd10027
195102000874	ligand binding site [chemical binding]; other site
195102000875	active site
195102000876	UGI interface [polypeptide binding]; other site
195102000877	catalytic site [active]
195102000878	Beta-glucosidase-related glycosidases [Carbohydrate transport and metabolism]; Region: BglX; COG1472
195102000879	Glycosyl hydrolase family 3 N terminal domain; Region: Glyco_hydro_3; pfam00933
195102000880	Glycosyl hydrolase family 3 C-terminal domain; Region: Glyco_hydro_3_C; pfam01915
195102000881	Peroxiredoxin [Posttranslational modification, protein turnover, chaperones]; Region: AhpC; COG0450
195102000882	Peroxiredoxin (PRX) family, Bacterioferritin comigratory protein (BCP) subfamily; composed of thioredoxin-dependent thiol peroxidases, widely expressed in pathogenic bacteria, that protect cells against toxicity from reactive oxygen species by reducing...; Region: PRX_BCP; cd03017
195102000883	catalytic triad [active]
195102000884	nitrogen fixation protein NifM; Region: nifM_nitrog; TIGR02933
195102000885	PPIC-type PPIASE domain; Region: Rotamase; pfam00639
195102000886	ABC-type polysaccharide/polyol phosphate export systems, permease component [Carbohydrate transport and metabolism / Cell envelope biogenesis, outer membrane]; Region: TagG; COG1682
195102000887	ABC-type polysaccharide/polyol phosphate transport system, ATPase component [Carbohydrate transport and metabolism / Cell envelope biogenesis, outer membrane]; Region: TagH; COG1134
195102000888	ATP-binding cassette component of polysaccharide transport system; Region: ABC_KpsT_Wzt; cd03220
195102000889	Walker A/P-loop; other site
195102000890	ATP binding site [chemical binding]; other site
195102000891	Q-loop/lid; other site
195102000892	ABC transporter signature motif; other site
195102000893	Walker B; other site
195102000894	D-loop; other site
195102000895	H-loop/switch region; other site
195102000896	C-Terminal domain of O-antigenic polysaccharide transporter protein Wzt and related proteins; Region: Wzt_C-like; cd10147
195102000897	putative carbohydrate binding site [chemical binding]; other site
195102000898	Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: GT1_like_1; cd04950
195102000899	Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438
195102000900	putative homodimer interface [polypeptide binding]; other site
195102000901	Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: GT1_like_1; cd04950
195102000902	Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438
195102000903	putative homodimer interface [polypeptide binding]; other site
195102000904	ABC-type polysaccharide/polyol phosphate transport system, ATPase component [Carbohydrate transport and metabolism / Cell envelope biogenesis, outer membrane]; Region: TagH; COG1134
195102000905	ATP-binding cassette component of polysaccharide transport system; Region: ABC_KpsT_Wzt; cd03220
195102000906	Walker A/P-loop; other site
195102000907	ATP binding site [chemical binding]; other site
195102000908	Q-loop/lid; other site
195102000909	ABC transporter signature motif; other site
195102000910	Walker B; other site
195102000911	D-loop; other site
195102000912	H-loop/switch region; other site
195102000913	C-Terminal domain of O-antigenic polysaccharide transporter protein Wzt and related proteins; Region: Wzt_C-like; cd10147
195102000914	putative carbohydrate binding site [chemical binding]; other site
195102000915	Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: GT1_like_1; cd04950
195102000916	Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438
195102000917	putative homodimer interface [polypeptide binding]; other site
195102000918	beta-phosphoglucomutase family hydrolase; Region: PGMB-YQAB-SF; TIGR02009
195102000919	haloacid dehalogenase-like hydrolase; Region: HAD; cl17202
195102000920	Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427
195102000921	motif II; other site
195102000922	Iron only hydrogenase large subunit, C-terminal domain [General function prediction only]; Region: COG4624
195102000923	Iron only hydrogenase large subunit, C-terminal domain; Region: Fe_hyd_lg_C; pfam02906
195102000924	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3883
195102000925	Cell wall-associated hydrolases (invasion-associated proteins) [Cell envelope biogenesis, outer membrane]; Region: Spr; COG0791
195102000926	NlpC/P60 family; Region: NLPC_P60; pfam00877
195102000927	Predicted O-methyltransferase [General function prediction only]; Region: COG4123
195102000928	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
195102000929	S-adenosylmethionine binding site [chemical binding]; other site
195102000930	Predicted methyltransferases [General function prediction only]; Region: COG0313
195102000931	Ribosomal RNA small subunit methyltransferase I, also known as rRNA (cytidine-2'-O-)-methyltransferase RsmI; Region: RsmI; cd11648
195102000932	putative SAM binding site [chemical binding]; other site
195102000933	putative homodimer interface [polypeptide binding]; other site
195102000934	SpoVT / AbrB like domain; Region: SpoVT_AbrB; smart00966
195102000935	Domain of unknown function (DUF1836); Region: DUF1836; pfam08876
195102000936	Aldose 1-epimerase, similar to Lactococcus lactis lacX; Region: Aldose_epim_lacX; cd09024
195102000937	active site
195102000938	catalytic residues [active]
195102000939	Transcriptional regulator [Transcription]; Region: LytR; COG1316
195102000940	Virulence factor BrkB; Region: Virul_fac_BrkB; pfam03631
195102000941	UDP-glucose 4-epimerase [Cell envelope biogenesis, outer membrane]; Region: GalE; COG1087
195102000942	UDP-glucose 4 epimerase, subgroup 1, extended (e) SDRs; Region: UDP_G4E_1_SDR_e; cd05247
195102000943	NAD binding site [chemical binding]; other site
195102000944	homodimer interface [polypeptide binding]; other site
195102000945	active site
195102000946	substrate binding site [chemical binding]; other site
195102000947	Single-stranded DNA-binding protein [DNA replication, recombination, and repair]; Region: Ssb; COG0629
195102000948	SSB_OBF: A subfamily of OB folds similar to the OB fold of ssDNA-binding protein (SSB). SSBs bind with high affinity to ssDNA. They bind to and protect ssDNA intermediates during DNA metabolic pathways. All bacterial and eukaryotic SSBs studied to date...; Region: SSB_OBF; cd04496
195102000949	dimer interface [polypeptide binding]; other site
195102000950	ssDNA binding site [nucleotide binding]; other site
195102000951	tetramer (dimer of dimers) interface [polypeptide binding]; other site
195102000952	Uncharacterized flavoproteins [Energy production and conversion]; Region: FpaA; COG0426
195102000953	Metallo-beta-lactamase superfamily; Region: Lactamase_B; smart00849
195102000954	Flavodoxin-like fold; Region: Flavodoxin_2; cl00438
195102000955	Endo-beta-N-acetylglucosaminidase D [Carbohydrate transport and metabolism]; Region: COG4724
195102000956	Endo-beta-N-acetylglucosaminidase (ENGase) hydrolyzes the N-N'-diacetylchitobiosyl core of N-glycosylproteins.  The beta-1,4-glycosyl bond located between two N-acetylglucosamine residues is hydrolyzed such that N-acetylglucosamine 1 remains with...; Region: GH85_ENGase; cd06547
195102000957	putative active site [active]
195102000958	FOG: PKD repeat [General function prediction only]; Region: COG3291
195102000959	polycystic kidney disease I (PKD) domain; similar to other cell-surface modules, with an IG-like fold; domain probably functions as a ligand binding site in protein-protein or protein-carbohydrate interactions; a single instance of the repeat is...; Region: PKD; cd00146
195102000960	F5/8 type C domain; Region: F5_F8_type_C; pfam00754
195102000961	sugar binding site [chemical binding]; other site
195102000962	Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all...; Region: FN3; cd00063
195102000963	Interdomain contacts; other site
195102000964	4'-phosphopantetheinyl transferase; Provisional; Region: acpS; PRK00070
195102000965	YjeF-related protein N-terminus; Region: YjeF_N; pfam03853
195102000966	B.subtilis YXKO protein of unknown function and related proteins. Based on the conservation of the ATP binding site, the substrate binding site and the Mg2+binding site and structural homology this group is a member of the ribokinase-like superfamily; Region: YXKO-related; cd01171
195102000967	putative substrate binding site [chemical binding]; other site
195102000968	putative ATP binding site [chemical binding]; other site
195102000969	PemK-like protein; Region: PemK; pfam02452
195102000970	transketolase; Reviewed; Region: PRK05899
195102000971	Thiamine pyrophosphate (TPP) family, Transketolase (TK) subfamily, TPP-binding module; TK catalyzes the transfer of a two-carbon unit from ketose phosphates to aldose phosphates. In heterotrophic organisms, TK provides a link between glycolysis and the...; Region: TPP_TK; cd02012
195102000972	TPP-binding site [chemical binding]; other site
195102000973	dimer interface [polypeptide binding]; other site
195102000974	Transketolase, C-terminal subunit [Carbohydrate transport and metabolism]; Region: COG3958
195102000975	Pyrimidine (PYR) binding domain of 1-deoxy-D-xylulose-5-phosphate synthase (DXS), transketolase (TK), and related proteins; Region: TPP_PYR_DXS_TK_like; cd07033
195102000976	PYR/PP interface [polypeptide binding]; other site
195102000977	dimer interface [polypeptide binding]; other site
195102000978	TPP binding site [chemical binding]; other site
195102000979	Transketolase, C-terminal domain; Region: Transketolase_C; pfam02780
195102000980	Uncharacterized conserved protein [Function unknown]; Region: COG1284
195102000981	Uncharacterized BCR, YitT family COG1284; Region: DUF161; pfam02588
195102000982	Uncharacterized BCR, YitT family COG1284; Region: DUF161; pfam02588
195102000983	Uncharacterized protein conserved in bacteria (DUF2179); Region: DUF2179; pfam10035
195102000984	Predicted ATPase involved in cell division [Cell division and chromosome partitioning]; Region: FtsE; COG2884
195102000985	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
195102000986	Walker A/P-loop; other site
195102000987	ATP binding site [chemical binding]; other site
195102000988	Q-loop/lid; other site
195102000989	ABC transporter signature motif; other site
195102000990	Walker B; other site
195102000991	D-loop; other site
195102000992	H-loop/switch region; other site
195102000993	Cell division protein [Cell division and chromosome partitioning]; Region: FtsX; COG2177
195102000994	cell division ABC transporter subunit FtsX; Provisional; Region: ftsX; PRK11026
195102000995	FtsX-like permease family; Region: FtsX; pfam02687
195102000996	Periplasmic protease [Cell envelope biogenesis, outer membrane]; Region: Prc; COG0793
195102000997	C-terminal processing peptidase family S41; Region: Peptidase_S41; cl02526
195102000998	PDZ domain of C-terminal processing-, tail-specific-, and tricorn proteases, which function in posttranslational protein processing, maturation, and disassembly or degradation, in Bacteria, Archaea, and plant chloroplasts. May be responsible for...; Region: PDZ_CTP_protease; cd00988
195102000999	protein binding site [polypeptide binding]; other site
195102001000	C-terminal processing peptidase; serine protease family S41; Region: Peptidase_S41_CPP; cd07560
195102001001	Catalytic dyad [active]
195102001002	excinuclease ABC subunit B; Provisional; Region: PRK05298
195102001003	DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046
195102001004	ATP binding site [chemical binding]; other site
195102001005	Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079
195102001006	nucleotide binding region [chemical binding]; other site
195102001007	ATP-binding site [chemical binding]; other site
195102001008	Ultra-violet resistance protein B; Region: UvrB; pfam12344
195102001009	UvrB/uvrC motif; Region: UVR; pfam02151
195102001010	EDD domain protein, DegV family; Region: DegV; TIGR00762
195102001011	Uncharacterized protein, DegV family COG1307; Region: DegV; pfam02645
195102001012	ABC-type Na+ transport system, ATPase component [Energy production and conversion / Inorganic ion transport and metabolism]; Region: NatA; COG4555
195102001013	ATP-binding cassette domain of the drug resistance transporter and related proteins, subfamily A; Region: ABC_DR_subfamily_A; cd03230
195102001014	Walker A/P-loop; other site
195102001015	ATP binding site [chemical binding]; other site
195102001016	Q-loop/lid; other site
195102001017	ABC transporter signature motif; other site
195102001018	Walker B; other site
195102001019	D-loop; other site
195102001020	H-loop/switch region; other site
195102001021	Esterase/lipase [Lipid metabolism]; Region: Aes; COG0657
195102001022	Esterases and lipases (includes fungal lipases, cholinesterases, etc.)  These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cd00312
195102001023	Prolyl oligopeptidase family; Region: Peptidase_S9; pfam00326
195102001024	Mismatch repair ATPase (MutS family) [DNA replication, recombination, and repair]; Region: MutS; COG0249
195102001025	ATP-binding cassette domain of MutS-like homolog; Region: ABC_MutS-like; cd03283
195102001026	Walker A/P-loop; other site
195102001027	ATP binding site [chemical binding]; other site
195102001028	Q-loop/lid; other site
195102001029	ABC transporter signature motif; other site
195102001030	Walker B; other site
195102001031	D-loop; other site
195102001032	H-loop/switch region; other site
195102001033	Transcriptional regulators [Transcription]; Region: FadR; COG2186
195102001034	Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377
195102001035	DNA-binding site [nucleotide binding]; DNA binding site
195102001036	FCD domain; Region: FCD; pfam07729
195102001037	L-lactate permease; Region: Lactate_perm; cl00701
195102001038	L-lactate permease [Energy production and conversion]; Region: LldP; COG1620
195102001039	The electron transfer flavoprotein (ETF) serves as a specific electron acceptor for various mitochondrial dehydrogenases. ETF transfers electrons to the main respiratory chain via ETF-ubiquinone oxidoreductase. ETF is an heterodimer that consists of an...; Region: ETF_beta; cd01714
195102001040	Ligand binding site [chemical binding]; other site
195102001041	Electron transfer flavoprotein domain; Region: ETF; pfam01012
195102001042	Electron transfer flavoprotein, alpha subunit [Energy production and conversion]; Region: FixB; COG2025
195102001043	The electron transfer flavoprotein (ETF) serves as a specific electron acceptor for various mitochondrial dehydrogenases. ETF transfers electrons to the main respiratory chain via ETF-ubiquinone oxidoreductase. ETF is an heterodimer that consists of an...; Region: ETF_alpha; cd01715
195102001044	Electron transfer flavoprotein FAD-binding domain; Region: ETF_alpha; pfam00766
195102001045	FAD binding domain; Region: FAD_binding_4; pfam01565
195102001046	glycolate oxidase, subunit GlcD; Region: glcD; TIGR00387
195102001047	TIGR03987 family protein; Region: TIGR03987
195102001048	signal peptidase I, bacterial type; Region: sigpep_I_bact; TIGR02227
195102001049	The S26 Type I signal peptidase (SPase; LepB; leader peptidase B; leader peptidase I; EC 3.4.21.89) family members are essential membrane-bound serine proteases that function to cleave the amino-terminal signal peptide extension from proteins that are...; Region: S26_SPase_I; cd06530
195102001050	Catalytic site [active]
195102001051	Transcriptional regulators of sugar metabolism [Transcription / Carbohydrate transport and metabolism]; Region: GlpR; COG1349
195102001052	DeoR-like helix-turn-helix domain; Region: HTH_DeoR; cl17531
195102001053	DeoR C terminal sensor domain; Region: DeoRC; pfam00455
195102001054	L-rhamnulose kinases; a subfamily of the FGGY family of carbohydrate kinases; Region: FGGY_RhuK; cd07771
195102001055	N- and C-terminal domain interface [polypeptide binding]; other site
195102001056	rhamnulokinase; Region: rhamnulo_kin; TIGR02627
195102001057	active site
195102001058	putative catalytic site [active]
195102001059	metal binding site [ion binding]; metal-binding site
195102001060	ATP binding site [chemical binding]; other site
195102001061	carbohydrate binding site [chemical binding]; other site
195102001062	L-fucose isomerase; Provisional; Region: fucI; PRK10991
195102001063	L-fucose isomerase (FucIase); FucIase converts L-fucose, an aldohexose, to its ketose form, which prepares it for aldol cleavage (similar to the isomerization of glucose during glycolysis). L-fucose (or 6-deoxy-L-galactose) is found in blood group...; Region: L-fucose_isomerase; cd03556
195102001064	hexamer (dimer of trimers) interface [polypeptide binding]; other site
195102001065	trimer interface [polypeptide binding]; other site
195102001066	substrate binding site [chemical binding]; other site
195102001067	Mn binding site [ion binding]; other site
195102001068	L-fuculose phosphate aldolase; Provisional; Region: PRK06833
195102001069	intersubunit interface [polypeptide binding]; other site
195102001070	active site
195102001071	Zn2+ binding site [ion binding]; other site
195102001072	PTS_IIA, PTS system, mannose/sorbose specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIA_man; cd00006
195102001073	active site
195102001074	active pocket/dimerization site; other site
195102001075	phosphorylation site [posttranslational modification]
195102001076	PTS_IIB, PTS system, Mannose/sorbose specific IIB subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIB_man; cd00001
195102001077	active site
195102001078	phosphorylation site [posttranslational modification]
195102001079	PTS system sorbose-specific iic component; Region: EII-Sor; pfam03609
195102001080	PTS system mannose/fructose/sorbose family IID component; Region: EIID-AGA; pfam03613
195102001081	Alpha-L-fucosidase; Region: Alpha_L_fucos; smart00812
195102001082	Alpha-L-fucosidase [Carbohydrate transport and metabolism]; Region: COG3669
195102001083	Melibiase; Region: Melibiase; pfam02065
195102001084	galactose-6-phosphate isomerase subunit LacA; Reviewed; Region: PRK08621
195102001085	galactose-6-phosphate isomerase subunit LacB; Reviewed; Region: PRK08622
195102001086	1-phosphofructokinase (FruK), minor 6-phosphofructokinase (pfkB) and related sugar kinases. FruK plays an important role in the predominant pathway for fructose utilisation.This group also contains tagatose-6-phophate kinase, an enzyme of the tagatose...; Region: FruK_PfkB_like; cd01164
195102001087	tagatose-6-phosphate kinase; Region: lacC; TIGR01231
195102001088	putative substrate binding site [chemical binding]; other site
195102001089	putative ATP binding site [chemical binding]; other site
195102001090	This novel putative carbohydrate binding module (NPCBM) domain is found at the N-terminus of glycosyl hydrolase family 98 proteins; Region: NPCBM; smart00776
195102001091	Glycosyl hydrolase family 98; Region: Glyco_hydro_98M; pfam08306
195102001092	Glycosyl hydrolase family 98 C-terminal domain; Region: Glyco_hydro_98C; pfam08307
195102001093	Protein of unknown function (DUF2809); Region: DUF2809; pfam10990
195102001094	Protein of unknown function (DUF975); Region: DUF975; pfam06161
195102001095	Uncharacterized membrane-associated protein [Function unknown]; Region: DedA; COG0586
195102001096	SNARE associated Golgi protein; Region: SNARE_assoc; pfam09335
195102001097	Cation transporter/ATPase, N-terminus; Region: Cation_ATPase_N; pfam00690
195102001098	Cation transport ATPase [Inorganic ion transport and metabolism]; Region: MgtA; COG0474
195102001099	E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122
195102001100	Putative hydrolase of sodium-potassium ATPase alpha subunit; Region: Hydrolase_like2; pfam13246
195102001101	haloacid dehalogenase-like hydrolase; Region: HAD; pfam12710
195102001102	Cation transporting ATPase, C-terminus; Region: Cation_ATPase_C; pfam00689
195102001103	Uncharacterized conserved protein [Function unknown]; Region: COG2013
195102001104	Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223
195102001105	active site
195102001106	EamA-like transporter family; Region: EamA; pfam00892
195102001107	Carboxylate/Amino Acid/Amine Transporter; Region: 2A78; TIGR00950
195102001108	EamA-like transporter family; Region: EamA; pfam00892
195102001109	amino acid transporter; Region: 2A0306; TIGR00909
195102001110	C-terminus of AA_permease; Region: AA_permease_C; pfam13906
195102001111	Domain of unknown function (DUF389); Region: DUF389; pfam04087
195102001112	Predicted Zn-dependent proteases and their inactivated homologs [General function prediction only]; Region: TldD; COG0312
195102001113	Predicted Zn-dependent proteases and their inactivated homologs [General function prediction only]; Region: TldD; COG0312
195102001114	aspartate 4-decarboxylase; Region: asp_4_decarbox; TIGR03801
195102001115	Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609
195102001116	pyridoxal 5'-phosphate binding site [chemical binding]; other site
195102001117	homodimer interface [polypeptide binding]; other site
195102001118	catalytic residue [active]
195102001119	Methylated DNA-protein cysteine methyltransferase [DNA replication, recombination, and repair]; Region: Ada; COG0350
195102001120	The DNA repair protein O6-alkylguanine-DNA alkyltransferase (ATase; also known as AGT, AGAT and MGMT) reverses O6-alkylation DNA damage by transferring O6-alkyl adducts to an active site cysteine irreversibly, without inducing DNA strand breaks. ATases...; Region: ATase; cd06445
195102001121	DNA binding site [nucleotide binding]
195102001122	active site
195102001123	ATP-dependent DNA helicase RecQ; Region: recQ; TIGR01389
195102001124	DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046
195102001125	ATP binding site [chemical binding]; other site
195102001126	putative Mg++ binding site [ion binding]; other site
195102001127	Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079
195102001128	nucleotide binding region [chemical binding]; other site
195102001129	ATP-binding site [chemical binding]; other site
195102001130	This DNA-binding domain is found in the RecQ helicase among others and has a helix-turn-helix structure; Region: RQC; smart00956
195102001131	HRDC domain; Region: HRDC; pfam00570
195102001132	N-Dimethylarginine dimethylaminohydrolase [Amino acid transport and metabolism]; Region: COG1834
195102001133	Amidinotransferase; Region: Amidinotransf; pfam02274
195102001134	Na+-driven multidrug efflux pump [Defense mechanisms]; Region: NorM; COG0534
195102001135	Uncharacterized subfamily of the multidrug and toxic compound extrusion (MATE) proteins; Region: MATE_like_8; cd13134
195102001136	Helix-Turn-Helix DNA binding domain of the transcription regulators TipAL, Mta, and SkgA; Region: HTH_TipAL-Mta; cd01106
195102001137	MerR HTH family regulatory protein; Region: MerR_1; pfam13411
195102001138	DNA binding residues [nucleotide binding]
195102001139	dimer interface [polypeptide binding]; other site
195102001140	TipAS antibiotic-recognition domain; Region: TipAS; pfam07739
195102001141	DNA-binding transcriptional activator YeiL; Provisional; Region: PRK10402
195102001142	effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038
195102001143	ligand binding site [chemical binding]; other site
195102001144	flexible hinge region; other site
195102001145	Crp-like helix-turn-helix domain; Region: HTH_Crp_2; pfam13545
195102001146	excinuclease ABC subunit A; Reviewed; Region: uvrA; PRK00349
195102001147	ATP-binding cassette domain I of the excision repair protein UvrA; Region: ABC_UvrA_I; cd03270
195102001148	ATP-binding cassette domain I of the excision repair protein UvrA; Region: ABC_UvrA_I; cd03270
195102001149	ATP-binding cassette domain II of the excision repair protein UvrA; Region: ABC_UvrA_II; cd03271
195102001150	Forkhead associated domain (FHA); found in eukaryotic and prokaryotic proteins. Putative nuclear signalling domain. FHA domains may bind phosphothreonine, phosphoserine and sometimes phosphotyrosine. In eukaryotes, many FHA domain-containing proteins...; Region: FHA; cd00060
195102001151	FOG: FHA domain [Signal transduction mechanisms]; Region: COG1716
195102001152	phosphopeptide binding site; other site
195102001153	Bacterial cell division membrane protein [Cell division and chromosome partitioning]; Region: FtsW; COG0772
195102001154	Penicillin binding protein transpeptidase domain; Region: Transpeptidase; pfam00905
195102001155	excinuclease ABC subunit C; Validated; Region: uvrC; PRK00558
195102001156	Catalytic GIY-YIG domain of nucleotide excision repair endonucleases UvrC, Cho, and similar proteins; Region: GIY-YIG_UvrC_Cho; cd10434
195102001157	GIY-YIG motif/motif A; other site
195102001158	active site
195102001159	catalytic site [active]
195102001160	putative DNA binding site [nucleotide binding]; other site
195102001161	metal binding site [ion binding]; metal-binding site
195102001162	UvrC Helix-hairpin-helix N-terminal; Region: UvrC_HhH_N; pfam08459
195102001163	UDP-N-acetylenolpyruvoylglucosamine reductase; Provisional; Region: murB; PRK13905
195102001164	FAD binding domain; Region: FAD_binding_4; pfam01565
195102001165	UDP-N-acetylenolpyruvoylglucosamine reductase, C-terminal domain; Region: MurB_C; pfam02873
195102001166	glmZ(sRNA)-inactivating NTPase; Provisional; Region: PRK05416
195102001167	Dephospho-CoA kinase [Coenzyme metabolism]; Region: CoaE; COG0237
195102001168	family of mostly uncharacterized proteins similar to B.subtilis YvcK; Region: YvcK_like; cd07187
195102001169	conserved hypothetical protein, cofD-related; Region: CofD_related; TIGR01826
195102001170	putative substrate binding pocket [chemical binding]; other site
195102001171	dimer interface [polypeptide binding]; other site
195102001172	phosphate binding site [ion binding]; other site
195102001173	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG1481
195102001174	Sporulation Regulator WhiA N terminal; Region: WhiA_N; pfam10298
195102001175	Domain of unknown function (DUF4179); Region: DUF4179; pfam13786
195102001176	RNA polymerase sigma factor, sigma-70 family; Region: sigma70-ECF; TIGR02937
195102001177	Sigma-70 region 2; Region: Sigma70_r2; pfam04542
195102001178	Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171
195102001179	DNA binding residues [nucleotide binding]
195102001180	DNA polymerase III DnaE; Reviewed; Region: dnaE; PRK06826
195102001181	Polymerase and Histidinol Phosphatase domain of alpha-subunit of bacterial polymerase III DnaE3; Region: PHP_PolIIIA_DnaE3; cd12113
195102001182	active site
195102001183	PHP Thumb interface [polypeptide binding]; other site
195102001184	metal binding site [ion binding]; metal-binding site
195102001185	DnaE_OBF: A subfamily of OB folds corresponding to the C-terminal OB-fold nucleic acid binding domain of Thermus aquaticus and Escherichia coli type C replicative DNA polymerase III alpha subunit (DnaE). The DNA polymerase holoenzyme of E. coli contains...; Region: DnaE_OBF; cd04485
195102001186	generic binding surface II; other site
195102001187	generic binding surface I; other site
195102001188	6-phosphofructokinase; Provisional; Region: PRK03202
195102001189	6-phosphofructokinase; Region: PFKA_ATP; TIGR02482
195102001190	active site
195102001191	ADP/pyrophosphate binding site [chemical binding]; other site
195102001192	dimerization interface [polypeptide binding]; other site
195102001193	allosteric effector site; other site
195102001194	fructose-1,6-bisphosphate binding site; other site
195102001195	Pyruvate kinase [Carbohydrate transport and metabolism]; Region: PykF; COG0469
195102001196	Pyruvate kinase (PK):  Large allosteric enzyme that regulates glycolysis through binding of the substrate, phosphoenolpyruvate, and one or more allosteric effectors. Like other allosteric enzymes, PK has a high substrate affinity R state and a low...; Region: Pyruvate_Kinase; cl17342
195102001197	domain interfaces; other site
195102001198	active site
195102001199	Domain of Unknown Function (DUF1540); Region: DUF1540; pfam07561
195102001200	Short-chain dehydrogenases of various substrate specificities [General function prediction only]; Region: DltE; COG0300
195102001201	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
195102001202	NAD(P) binding site [chemical binding]; other site
195102001203	active site
195102001204	Phosphatidylserine/phosphatidylglycerophosphate/car diolipin synthases and related enzymes [Lipid metabolism]; Region: Cls; COG1502
195102001205	Putative catalytic domain, repeat 1, of Streptococcus mutans uncharacterized protein SMU_988 and similar proteins; Region: PLDc_SMU_988_like_1; cd09154
195102001206	putative active site [active]
195102001207	catalytic site [active]
195102001208	Putative catalytic domain, repeat 2, of Streptococcus mutans uncharacterized protein SMU_988 and similar proteins; Region: PLDc_SMU_988_like_2; cd09160
195102001209	putative active site [active]
195102001210	catalytic site [active]
195102001211	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain (MocR family) and their eukaryotic orthologs [Transcription / Amino acid transport and metabolism]; Region: ARO8; COG1167
195102001212	Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377
195102001213	DNA-binding site [nucleotide binding]; DNA binding site
195102001214	Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609
195102001215	pyridoxal 5'-phosphate binding site [chemical binding]; other site
195102001216	homodimer interface [polypeptide binding]; other site
195102001217	catalytic residue [active]
195102001218	TRAM domain; Region: TRAM; cl01282
195102001219	SAM-dependent methyltransferases related to tRNA (uracil-5-)-methyltransferase [Translation, ribosomal structure and biogenesis]; Region: TrmA; COG2265
195102001220	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
195102001221	S-adenosylmethionine binding site [chemical binding]; other site
195102001222	AraC-like ligand binding domain; Region: AraC_binding; pfam02311
195102001223	Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165
195102001224	helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342
195102001225	Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165
195102001226	ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653
195102001227	Bacterial extracellular solute-binding protein; Region: SBP_bac_1; pfam01547
195102001228	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
195102001229	dimer interface [polypeptide binding]; other site
195102001230	conserved gate region; other site
195102001231	putative PBP binding loops; other site
195102001232	ABC-ATPase subunit interface; other site
195102001233	ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395
195102001234	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
195102001235	dimer interface [polypeptide binding]; other site
195102001236	conserved gate region; other site
195102001237	putative PBP binding loops; other site
195102001238	ABC-ATPase subunit interface; other site
195102001239	Alpha-galactosidase [Carbohydrate transport and metabolism]; Region: GalA; COG3345
195102001240	Melibiase; Region: Melibiase; pfam02065
195102001241	F5/8 type C domain; Region: F5_F8_type_C; pfam00754
195102001242	Laminarinase, member of the glycosyl hydrolase family 16; Region: GH16_laminarinase_like; cd08023
195102001243	active site
195102001244	catalytic residues [active]
195102001245	probable dihydroxyacetone kinase regulator; Region: DHAK_reg; TIGR02366
195102001246	Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440
195102001247	myosin-cross-reactive antigen; Provisional; Region: PRK13977
195102001248	ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132
195102001249	ABC transporter transmembrane region; Region: ABC_membrane; pfam00664
195102001250	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
195102001251	Walker A/P-loop; other site
195102001252	ATP binding site [chemical binding]; other site
195102001253	Q-loop/lid; other site
195102001254	ABC transporter signature motif; other site
195102001255	Walker B; other site
195102001256	D-loop; other site
195102001257	H-loop/switch region; other site
195102001258	ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132
195102001259	ABC transporter transmembrane region; Region: ABC_membrane; pfam00664
195102001260	ATP-binding cassette domain of glucan transporter and related proteins, subfamily C; Region: ABCC_Glucan_exporter_like; cd03254
195102001261	Walker A/P-loop; other site
195102001262	ATP binding site [chemical binding]; other site
195102001263	Q-loop/lid; other site
195102001264	ABC transporter signature motif; other site
195102001265	Walker B; other site
195102001266	D-loop; other site
195102001267	H-loop/switch region; other site
195102001268	Ferritin-like superfamily of diiron-containing four-helix-bundle proteins; Region: Ferritin_like; cl00264
195102001269	dinuclear metal binding motif [ion binding]; other site
195102001270	Lyc muramidase is an autolytic lysozyme (autolysin) from Clostridium acetobutylicum encoded by the lyc gene. Lyc has a glycosyl hydrolase family 25 (GH25) catalytic domain.  Endo-N-acetylmuramidases are lysozymes (also referred to as peptidoglycan...; Region: GH25_Lyc-like; cd06525
195102001271	Glycosyl hydrolases family 25; Region: Glyco_hydro_25; pfam01183
195102001272	active site
195102001273	Bacterial SH3 domain; Region: SH3_3; pfam08239
195102001274	Bacterial SH3 domain homologues; Region: SH3b; smart00287
195102001275	toxin secretion/phage lysis holin; Region: holin_tox_secr; TIGR01593
195102001276	Putative catalytic NodB homology domain of PgaB, IcaB, and similar proteins which consist of a deformed (beta/alpha)8 barrel fold with 5- or 6-strands; Region: CE4_NodB_like_5s_6s; cd10918
195102001277	putative active site [active]
195102001278	putative metal binding site [ion binding]; other site
195102001279	3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05653
195102001280	classical (c) SDRs; Region: SDR_c; cd05233
195102001281	NAD(P) binding site [chemical binding]; other site
195102001282	active site
195102001283	Transcriptional regulators [Transcription]; Region: PhnF; COG2188
195102001284	Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377
195102001285	DNA-binding site [nucleotide binding]; DNA binding site
195102001286	Uridine phosphorylase [Nucleotide transport and metabolism]; Region: Udp; COG2820
195102001287	Phosphorylase superfamily; Region: PNP_UDP_1; cl00303
195102001288	phosphopentomutase; Provisional; Region: PRK05362
195102001289	Metalloenzyme superfamily; Region: Metalloenzyme; pfam01676
195102001290	transporter, basic amino acid/polyamine antiporter (APA) family; Region: 2A0302; TIGR00905
195102001291	histidine decarboxylase, pyruvoyl type; Region: hisDCase_pyru; TIGR00541
195102001292	Bacillus subtilis YkuE and related proteins, C-terminal metallophosphatase domain; Region: MPP_YkuE_C; cd07385
195102001293	Calcineurin-like phosphoesterase; Region: Metallophos; pfam00149
195102001294	putative active site [active]
195102001295	putative metal binding site [ion binding]; other site
195102001296	3-hydroxyisobutyrate dehydrogenase and related beta-hydroxyacid dehydrogenases [Lipid metabolism]; Region: MmsB; COG2084
195102001297	6-phosphogluconate dehydrogenase-like protein; Reviewed; Region: PRK09599
195102001298	Quinolinate synthetase A protein; Region: NadA; pfam02445
195102001299	L-aspartate oxidase; Provisional; Region: PRK06175
195102001300	FAD binding domain; Region: FAD_binding_2; pfam00890
195102001301	Nicotinate-nucleotide pyrophosphorylase [Coenzyme metabolism]; Region: NadC; COG0157
195102001302	Quinolinate phosphoribosyl transferase (QAPRTase or QPRTase), also called nicotinate-nucleotide pyrophosphorylase, is involved in the de novo synthesis of NAD in both prokaryotes and eukaryotes. It catalyses the reaction of quinolinic acid (QA) with...; Region: QPRTase; cd01572
195102001303	dimerization interface [polypeptide binding]; other site
195102001304	active site
195102001305	xanthine permease; Region: pbuX; TIGR03173
195102001306	purine nucleoside phosphorylase; Provisional; Region: PRK08202
195102001307	nicotinamide mononucleotide transporter PnuC; Region: NMN_trans_PnuC; TIGR01528
195102001308	cAMP-binding proteins - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases [Signal transduction mechanisms]; Region: Crp; COG0664
195102001309	effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038
195102001310	ligand binding site [chemical binding]; other site
195102001311	flexible hinge region; other site
195102001312	helix_turn_helix, cAMP Regulatory protein C-terminus; DNA binding domain of prokaryotic regulatory proteins belonging to the catabolite activator protein family; Region: HTH_CRP; cl17320
195102001313	SH3 domain protein; Region: SH3_and_anchor; TIGR04211
195102001314	Nsp1-like C-terminal region; Region: Nsp1_C; pfam05064
195102001315	YcxB-like protein; Region: YcxB; pfam14317
195102001316	Branched-chain amino acid transport protein; Region: Branch_AA_trans; pfam05525
195102001317	Uncharacterized conserved protein [Function unknown]; Region: COG1284
195102001318	Uncharacterized BCR, YitT family COG1284; Region: DUF161; pfam02588
195102001319	Uncharacterized BCR, YitT family COG1284; Region: DUF161; pfam02588
195102001320	Uncharacterized protein conserved in bacteria (DUF2179); Region: DUF2179; pfam10035
195102001321	FAD/FMN-containing dehydrogenases [Energy production and conversion]; Region: GlcD; COG0277
195102001322	FAD binding domain; Region: FAD_binding_4; pfam01565
195102001323	Berberine and berberine like; Region: BBE; pfam08031
195102001324	Predicted hydrolases of the HAD superfamily [General function prediction only]; Region: Cof; COG0561
195102001325	Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427
195102001326	active site
195102001327	motif I; other site
195102001328	motif II; other site
195102001329	Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427
195102001330	Predicted dehydrogenase [General function prediction only]; Region: COG0579
195102001331	hydroxyglutarate oxidase; Provisional; Region: PRK11728
195102001332	BFD-like [2Fe-2S] binding domain; Region: Fer2_BFD; pfam04324
195102001333	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG0675
195102001334	Helix-turn-helix domain; Region: HTH_OrfB_IS605; pfam12323
195102001335	Probable transposase; Region: OrfB_IS605; pfam01385
195102001336	transposase, IS605 OrfB family, central region; Region: tspaseT_teng_C; TIGR01766
195102001337	CoA-disulfide reductase; Region: CoA_CoA_reduc; TIGR03385
195102001338	GGCT-like domains, also called AIG2-like family. Gamma-glutamyl cyclotransferase (GGCT) catalyzes the formation of pyroglutamic acid (5-oxoproline) from dipeptides containing gamma-glutamyl, and is a dimeric protein. In Homo sapiens, the protein is...; Region: GGCT_like; cd06661
195102001339	putative active site pocket [active]
195102001340	dimerization interface [polypeptide binding]; other site
195102001341	putative catalytic residue [active]
195102001342	Carbonic anhydrases (CA) are zinc-containing enzymes that catalyze the reversible hydration of carbon dioxide in a two-step mechanism in which the nucleophilic attack of a zinc-bound hydroxide ion on carbon dioxide is followed by the regeneration of an...; Region: beta_CA_cladeD; cd03379
195102001343	active site clefts [active]
195102001344	zinc binding site [ion binding]; other site
195102001345	dimer interface [polypeptide binding]; other site
195102001346	Protein of unknown function (DUF1113); Region: DUF1113; pfam06541
195102001347	zinc-ribbon domain; Region: zf-ribbon_3; pfam13248
195102001348	heat shock protein 90; Provisional; Region: PRK05218
195102001349	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
195102001350	ATP binding site [chemical binding]; other site
195102001351	Mg2+ binding site [ion binding]; other site
195102001352	G-X-G motif; other site
195102001353	Transcriptional regulators [Transcription]; Region: PurR; COG1609
195102001354	Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392
195102001355	DNA binding site [nucleotide binding]
195102001356	domain linker motif; other site
195102001357	Ligand-binding domain of uncharacterized transcription regulator ycjW which is a member of the LacI-GalR family repressors; Region: PBP1_ycjW_transcription_regulator_like; cd06294
195102001358	putative dimerization interface [polypeptide binding]; other site
195102001359	putative ligand binding site [chemical binding]; other site
195102001360	alpha,alpha-phosphotrehalase; Region: trehalose_treC; TIGR02403
195102001361	Alpha amylase catalytic domain found in Sucrose isomerases, oligo-1,6-glucosidase (also called isomaltase; sucrase-isomaltase; alpha-limit dextrinase), dextran glucosidase (also called glucan 1,6-alpha-glucosidase), and related proteins; Region: AmyAc_SI_OligoGlu_DGase; cd11333
195102001362	Ca binding site [ion binding]; other site
195102001363	active site
195102001364	catalytic site [active]
195102001365	PTS system, IIBC component; Region: PTS-II-BC-unk1; TIGR02003
195102001366	Phosphotransferase system IIC components, glucose/maltose/N-acetylglucosamine-specific [Carbohydrate transport and metabolism]; Region: PtsG; COG1263
195102001367	PTS_IIB, PTS system, glucose/sucrose specific IIB subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIB_glc; cd00212
195102001368	active site turn [active]
195102001369	phosphorylation site [posttranslational modification]
195102001370	Streptococcus agalactiae RgfB, part of a putative two component signal transduction system, and related proteins; Region: RgfB-like; cd09079
195102001371	putative catalytic site [active]
195102001372	putative metal binding site [ion binding]; other site
195102001373	putative phosphate binding site [ion binding]; other site
195102001374	Glycerophosphoryl diester phosphodiesterase [Energy production and conversion]; Region: UgpQ; COG0584
195102001375	Glycerophosphodiester phosphodiesterase domain of Thermoanaerobacter tengcongensis and similar proteins; Region: GDPD_TtGDE_like; cd08563
195102001376	active site
195102001377	catalytic site [active]
195102001378	metal binding site [ion binding]; metal-binding site
195102001379	dimer interface [polypeptide binding]; other site
195102001380	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
195102001381	putative substrate translocation pore; other site
195102001382	Major Facilitator Superfamily; Region: MFS_1; pfam07690
195102001383	UvrD/REP helicase N-terminal domain; Region: UvrD-helicase; pfam00580
195102001384	Part of AAA domain; Region: AAA_19; pfam13245
195102001385	exonuclease, DNA polymerase III, epsilon subunit family; Region: dnaq; TIGR00573
195102001386	DEDDh 3'-5' exonuclease domain family; Region: DEDDh; cd06127
195102001387	active site
195102001388	catalytic site [active]
195102001389	substrate binding site [chemical binding]; other site
195102001390	Family description; Region: UvrD_C_2; pfam13538
195102001391	tRNA (guanine-N(7)-)-methyltransferase; Reviewed; Region: trmB; PRK00121
195102001392	PD-(D/E)XK nuclease family transposase; Region: PDDEXK_2; pfam12784
195102001393	conserved hypothetical protein (putative transposase or invertase); Region: T_den_put_tspse; TIGR01784
195102001394	Uncharacterized conserved protein [Function unknown]; Region: COG3538
195102001395	Protein of unknown function (DUF1237); Region: DUF1237; pfam06824
195102001396	signal peptidase I, bacterial type; Region: sigpep_I_bact; TIGR02227
195102001397	The S24, S26 LexA/signal peptidase superfamily contains LexA-related and type I signal peptidase families. The S24 LexA protein domains include: the lambda repressor CI/C2 family and related bacterial prophage repressor proteins; LexA (EC 3.4.21.88), the...; Region: Peptidase_S24_S26; cd06462
195102001398	Catalytic site [active]
195102001399	Bacillus subtilis YkuE and related proteins, C-terminal metallophosphatase domain; Region: MPP_YkuE_C; cd07385
195102001400	putative active site [active]
195102001401	putative metal binding site [ion binding]; other site
195102001402	Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697
195102001403	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301
195102001404	Coenzyme A binding pocket [chemical binding]; other site
195102001405	YtxH-like protein; Region: YtxH; pfam12732
195102001406	Hemolysins and related proteins containing CBS domains [General function prediction only]; Region: TlyC; COG1253
195102001407	Domain of unknown function DUF21; Region: DUF21; pfam01595
195102001408	This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains associated with the CorC_HlyC domain. CorC_HlyC is a transporter associated domain. This small domain is found in Na+/H+ antiporters, in proteins involved in...; Region: CBS_pair_CorC_HlyC_assoc; cd04590
195102001409	Transporter associated domain; Region: CorC_HlyC; pfam03471
195102001410	Bacterial extracellular solute-binding protein; Region: SBP_bac_8; pfam13416
195102001411	ABC-type Fe3+ transport system, periplasmic component [Inorganic ion transport and metabolism]; Region: AfuA; COG1840
195102001412	ABC-type Fe3+ transport system, permease component [Inorganic ion transport and metabolism]; Region: ThiP; COG1178
195102001413	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
195102001414	dimer interface [polypeptide binding]; other site
195102001415	conserved gate region; other site
195102001416	putative PBP binding loops; other site
195102001417	ABC-ATPase subunit interface; other site
195102001418	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
195102001419	dimer interface [polypeptide binding]; other site
195102001420	conserved gate region; other site
195102001421	putative PBP binding loops; other site
195102001422	ABC-ATPase subunit interface; other site
195102001423	ABC-type polar amino acid transport system, ATPase component [Amino acid transport and metabolism]; Region: GlnQ; COG1126
195102001424	ATP-binding cassette domain of the carbohydrate and solute transporters-like; Region: ABC_Carb_Solutes_like; cd03259
195102001425	Walker A/P-loop; other site
195102001426	ATP binding site [chemical binding]; other site
195102001427	Q-loop/lid; other site
195102001428	ABC transporter signature motif; other site
195102001429	Walker B; other site
195102001430	D-loop; other site
195102001431	H-loop/switch region; other site
195102001432	Nitrite/Sulfite reductase ferredoxin-like half domain; Region: NIR_SIR_ferr; pfam03460
195102001433	Nitrite and sulphite reductase 4Fe-4S domain; Region: NIR_SIR; pfam01077
195102001434	BFD-like [2Fe-2S] binding domain; Region: Fer2_BFD; cl01093
195102001435	Predicted transcriptional regulators [Transcription]; Region: COG1725
195102001436	Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377
195102001437	DNA-binding site [nucleotide binding]; DNA binding site
195102001438	ABC-type multidrug transport system, ATPase component [Defense mechanisms]; Region: CcmA; COG1131
195102001439	ATP-binding cassette domain of the drug resistance transporter and related proteins, subfamily A; Region: ABC_DR_subfamily_A; cd03230
195102001440	Walker A/P-loop; other site
195102001441	ATP binding site [chemical binding]; other site
195102001442	Q-loop/lid; other site
195102001443	ABC transporter signature motif; other site
195102001444	Walker B; other site
195102001445	D-loop; other site
195102001446	H-loop/switch region; other site
195102001447	ABC-2 family transporter protein; Region: ABC2_membrane_5; pfam13346
195102001448	Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903
195102001449	Glyoxalase I catalyzes the isomerization of the hemithioacetal, formed by a 2-oxoaldehyde and glutathione, to S-D-lactoylglutathione; Region: Glyoxalase_I; cd07233
195102001450	dimer interface [polypeptide binding]; other site
195102001451	active site
195102001452	metal binding site [ion binding]; metal-binding site
195102001453	glutathione binding site [chemical binding]; other site
195102001454	AraC-type transcriptional regulator N-terminus; Region: AraC_N; pfam06719
195102001455	Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165
195102001456	helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342
195102001457	Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165
195102001458	Lactadehyde:propanediol oxidoreductase (LPO) catalyzes the interconversion between L-lactaldehyde and L-1,2-propanediol in Escherichia coli and other enterobacteria; Region: LPO; cd08176
195102001459	putative alcohol dehydrogenase; Provisional; Region: PRK09860
195102001460	dimer interface [polypeptide binding]; other site
195102001461	active site
195102001462	metal binding site [ion binding]; metal-binding site
195102001463	This putative domain contains a quite highly conserved sequence of CGGC in its central region; Region: CGGC; smart01078
195102001464	This conserved domain belongs to a superfamily including the bleomycin resistance protein, glyoxalase I, and type I ring-cleaving dioxygenases; Region: Glo_EDI_BRP_like_1; cd08352
195102001465	Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903
195102001466	putative metal binding site [ion binding]; other site
195102001467	Bacterial SH3 domain; Region: SH3_3; pfam08239
195102001468	Helix-Turn-Helix DNA binding domain of the BmrR transcription regulator; Region: HTH_BmrR; cd01107
195102001469	MerR HTH family regulatory protein; Region: MerR_1; pfam13411
195102001470	DNA binding residues [nucleotide binding]
195102001471	drug binding residues [chemical binding]; other site
195102001472	dimer interface [polypeptide binding]; other site
195102001473	Fusaric acid resistance protein-like; Region: FUSC_2; pfam13515
195102001474	Uncharacterized membrane-associated protein [Function unknown]; Region: DedA; COG0586
195102001475	SNARE associated Golgi protein; Region: SNARE_assoc; pfam09335
195102001476	Lysophospholipid acyltransferases (LPLATs) of glycerophospholipid biosynthesis; Region: LPLAT; cl17185
195102001477	putative acyl-acceptor binding pocket; other site
195102001478	Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745
195102001479	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
195102001480	active site
195102001481	phosphorylation site [posttranslational modification]
195102001482	intermolecular recognition site; other site
195102001483	dimerization interface [polypeptide binding]; other site
195102001484	Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383
195102001485	DNA binding site [nucleotide binding]
195102001486	Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642
195102001487	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
195102001488	dimer interface [polypeptide binding]; other site
195102001489	phosphorylation site [posttranslational modification]
195102001490	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
195102001491	ATP binding site [chemical binding]; other site
195102001492	Mg2+ binding site [ion binding]; other site
195102001493	G-X-G motif; other site
195102001494	Fusaric acid resistance protein-like; Region: FUSC_2; pfam13515
195102001495	Capsular polysaccharide biosynthesis protein [Cell envelope biogenesis, outer membrane]; Region: COG3944
195102001496	Chain length determinant protein; Region: Wzz; cl15801
195102001497	capsular exopolysaccharide family; Region: eps_fam; TIGR01007
195102001498	The Fer4_NifH superfamily contains a variety of proteins which share a common ATP-binding domain. Functionally, proteins in this superfamily use the energy from hydrolysis of NTP to transfer electron or ion; Region: Fer4_NifH; cl17203
195102001499	Predicted nucleoside-diphosphate sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: COG1086
195102001500	Left-handed parallel beta-Helix (LbetaH or LbH) domain: The alignment contains 5 turns, each containing three imperfect tandem repeats of a hexapeptide repeat motif (X-[STAV]-X-[LIV]-[GAED]-X). Proteins containing hexapeptide repeats are often enzymes...; Region: LbetaH; cl00160
195102001501	UDP-Glcnac (UDP-linked N-acetylglucosamine) inverting 4,6-dehydratase, extended (e) SDRs; Region: UDP_invert_4-6DH_SDR_e; cd05237
195102001502	NAD(P) binding site [chemical binding]; other site
195102001503	homodimer interface [polypeptide binding]; other site
195102001504	substrate binding site [chemical binding]; other site
195102001505	active site
195102001506	aminotransferase, LLPSF_NHT_00031 family; Region: NHT_00031; TIGR04181
195102001507	3-amino-5-hydroxybenzoic acid synthase family (AHBA_syn). AHBA_syn family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The members of this CD are involved in various biosynthetic pathways for secondary...; Region: AHBA_syn; cd00616
195102001508	inhibitor-cofactor binding pocket; inhibition site
195102001509	pyridoxal 5'-phosphate binding site [chemical binding]; other site
195102001510	catalytic residue [active]
195102001511	Serine kinase of the HPr protein, regulates carbohydrate metabolism [Signal transduction mechanisms]; Region: HprK; COG1493
195102001512	Phosphoenolpyruvate carboxykinase (PEPCK), a critical gluconeogenic enzyme, catalyzes the first committed step in the diversion of tricarboxylic acid cycle intermediates toward gluconeogenesis. It catalyzes the reversible decarboxylation and...; Region: PEPCK_HprK; cl00270
195102001513	active site
195102001514	metal-binding site [ion binding]
195102001515	nucleotide-binding site [chemical binding]; other site
195102001516	Coenzyme PQQ synthesis protein D (PqqD); Region: PqqD; cl05126
195102001517	Transglutaminase-like superfamily; Region: Transglut_core3; pfam13471
195102001518	ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132
195102001519	ABC transporter transmembrane region; Region: ABC_membrane; pfam00664
195102001520	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
195102001521	Walker A/P-loop; other site
195102001522	ATP binding site [chemical binding]; other site
195102001523	Q-loop/lid; other site
195102001524	ABC transporter signature motif; other site
195102001525	Walker B; other site
195102001526	D-loop; other site
195102001527	H-loop/switch region; other site
195102001528	Bacterial sugar transferase; Region: Bac_transf; pfam02397
195102001529	Putative Acyltransferase (AT), Left-handed parallel beta-Helix (LbH) domain; This group is composed of mostly uncharacterized proteins containing an N-terminal helical subdomain followed by a LbH domain. The alignment contains 6 turns, each containing...; Region: LbH_AT_putative; cd03360
195102001530	sugar O-acyltransferase, sialic acid O-acetyltransferase NeuD family; Region: NeuD_NnaD; TIGR03570
195102001531	putative trimer interface [polypeptide binding]; other site
195102001532	putative CoA binding site [chemical binding]; other site
195102001533	Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438
195102001534	This family is most closely related to the GT1 family of glycosyltransferases. cap1E in Streptococcus pneumoniae is required for the synthesis of type 1 capsular polysaccharides; Region: GT1_cap1E_like; cd03808
195102001535	putative ADP-binding pocket [chemical binding]; other site
195102001536	Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438
195102001537	This family is most closely related to the GT1 family of glycosyltransferases and named after YqgM in Bacillus licheniformis about which little is known. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to...; Region: GT1_YqgM_like; cd03801
195102001538	Glycosyltransferases involved in cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WcaA; COG0463
195102001539	Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cd00761
195102001540	active site
195102001541	Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438
195102001542	This family is most closely related to the GT1 family of glycosyltransferases. capH in Staphylococcus aureus has been shown to be required for the biosynthesis of the type 1 capsular polysaccharide (CP1); Region: GT1_CapH_like; cd03812
195102001543	putative ADP-binding pocket [chemical binding]; other site
195102001544	Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438
195102001545	This family is most closely related to the GT1 family of glycosyltransferases. WabH in Klebsiella pneumoniae has been shown to transfer a GlcNAc residue from UDP-GlcNAc onto the acceptor GalUA residue in the cellular outer core; Region: GT1_WabH_like; cd03811
195102001546	putative ADP-binding pocket [chemical binding]; other site
195102001547	putative glycosyl transferase; Provisional; Region: PRK10073
195102001548	Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cd00761
195102001549	active site
195102001550	Putative glycosyl/glycerophosphate transferases involved in teichoic acid biosynthesis TagF/TagB/EpsJ/RodC [Cell envelope biogenesis, outer membrane]; Region: TagB; COG1887
195102001551	CDP-Glycerol:Poly(glycerophosphate) glycerophosphotransferase; Region: Glyphos_transf; pfam04464
195102001552	nucleotidyl transferase superfamily; Region: nt_trans; cl00015
195102001553	Cytidylyltransferase; Region: CTP_transf_2; pfam01467
195102001554	active site
195102001555	nucleotide binding site [chemical binding]; other site
195102001556	HIGH motif; other site
195102001557	KMSKS motif; other site
195102001558	Glycosyl transferase family 2; Region: Glycos_transf_2; pfam00535
195102001559	active site
195102001560	Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438
195102001561	This family is most closely related to the GT1 family of glycosyltransferases. WabH in Klebsiella pneumoniae has been shown to transfer a GlcNAc residue from UDP-GlcNAc onto the acceptor GalUA residue in the cellular outer core; Region: GT1_WabH_like; cd03811
195102001562	putative ADP-binding pocket [chemical binding]; other site
195102001563	Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438
195102001564	This family is most closely related to the GT1 family of glycosyltransferases. WabH in Klebsiella pneumoniae has been shown to transfer a GlcNAc residue from UDP-GlcNAc onto the acceptor GalUA residue in the cellular outer core; Region: GT1_WabH_like; cd03811
195102001565	putative ADP-binding pocket [chemical binding]; other site
195102001566	Glycosyl hydrolase families: GH43, GH62, GH32, GH68; Region: GH43_62_32_68; cl14647
195102001567	This family is most closely related to the GT1 family of glycosyltransferases. WabH in Klebsiella pneumoniae has been shown to transfer a GlcNAc residue from UDP-GlcNAc onto the acceptor GalUA residue in the cellular outer core; Region: GT1_WabH_like; cd03811
195102001568	putative ADP-binding pocket [chemical binding]; other site
195102001569	Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438
195102001570	GlcNAc-PI de-N-acetylase; Region: PIG-L; pfam02585
195102001571	Chain length determinant protein; Region: Wzz; cl15801
195102001572	Capsular polysaccharide biosynthesis protein [Cell envelope biogenesis, outer membrane]; Region: COG3944
195102001573	capsular exopolysaccharide family; Region: eps_fam; TIGR01007
195102001574	The Fer4_NifH superfamily contains a variety of proteins which share a common ATP-binding domain. Functionally, proteins in this superfamily use the energy from hydrolysis of NTP to transfer electron or ion; Region: Fer4_NifH; cl17203
195102001575	exopolysaccharide biosynthesis polyprenyl glycosylphosphotransferase; Region: EPS_sugtrans; TIGR03025
195102001576	Bacterial sugar transferase; Region: Bac_transf; pfam02397
195102001577	Predicted UDP-glucose 6-dehydrogenase [Cell envelope biogenesis, outer membrane]; Region: Ugd; COG1004
195102001578	NAD-dependent glycerol-3-phosphate dehydrogenase N-terminus; Region: NAD_Gly3P_dh_N; pfam01210
195102001579	UDP-glucose/GDP-mannose dehydrogenase family, central domain; Region: UDPG_MGDP_dh; pfam00984
195102001580	UDP binding domain; Region: UDPG_MGDP_dh_C; smart00984
195102001581	Mannose-1-phosphate guanylyltransferase [Cell envelope biogenesis, outer membrane]; Region: {ManC}; COG0836
195102001582	GDP-M1P_Guanylyltransferase catalyzes the formation of GDP-Mannose; Region: GDP-M1P_Guanylyltransferase; cd02509
195102001583	Substrate binding site; other site
195102001584	Teichoic acid biosynthesis proteins [Cell envelope biogenesis, outer membrane]; Region: WecG; COG1922
195102001585	The glycosyltransferase WecG/TagA superfamily contains Escherichia coli WecG, Bacillus subtilis TagA and related proteins. E. coli WecG is believed to be a UDP-N-acetyl-D-mannosaminuronic acid transferase, and is involved in enterobacterial common...; Region: Glyco_transf_WecG_TagA; cd06533
195102001586	Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013
195102001587	This family is most closely related to the GT1 family of glycosyltransferases and named after YqgM in Bacillus licheniformis about which little is known. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to...; Region: GT1_YqgM_like; cd03801
195102001588	Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438
195102001589	Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438
195102001590	This family is most closely related to the GT1 family of glycosyltransferases and named after YqgM in Bacillus licheniformis about which little is known. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to...; Region: GT1_YqgM_like; cd03801
195102001591	Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438
195102001592	This family is most closely related to the GT1 family of glycosyltransferases. ExpE7 in Sinorhizobium meliloti has been shown to be involved in the biosynthesis of galactoglucans (exopolysaccharide II); Region: GT1_ExpE7_like; cd03823
195102001593	Glycosyltransferases involved in cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WcaA; COG0463
195102001594	Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cd00761
195102001595	active site
195102001596	Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438
195102001597	This family is most closely related to the GT1 family of glycosyltransferases. WabH in Klebsiella pneumoniae has been shown to transfer a GlcNAc residue from UDP-GlcNAc onto the acceptor GalUA residue in the cellular outer core; Region: GT1_WabH_like; cd03811
195102001598	putative ADP-binding pocket [chemical binding]; other site
195102001599	Glycosyltransferases involved in cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WcaA; COG0463
195102001600	Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cd00761
195102001601	active site
195102001602	Multidrug and toxic compound extrusion family and similar proteins; Region: MATE_like; cl09326
195102001603	dTDP-glucose pyrophosphorylase [Cell envelope biogenesis, outer membrane]; Region: RfbA; COG1209
195102001604	Prokaryotic UGPase catalyses the synthesis of UDP-glucose; Region: UGPase_prokaryotic; cd02541
195102001605	active site
195102001606	tetramer interface; other site
195102001607	Helix-turn-helix domain; Region: HTH_16; pfam12645
195102001608	RNA polymerase sigma factor, sigma-70 family; Region: sigma70-ECF; TIGR02937
195102001609	UDP-glucose 4-epimerase; Region: PLN02240
195102001610	UDP-glucose 4 epimerase, subgroup 1, extended (e) SDRs; Region: UDP_G4E_1_SDR_e; cd05247
195102001611	NAD binding site [chemical binding]; other site
195102001612	homodimer interface [polypeptide binding]; other site
195102001613	active site
195102001614	substrate binding site [chemical binding]; other site
195102001615	Prokaryotic UGPase catalyses the synthesis of UDP-glucose; Region: UGPase_prokaryotic; cd02541
195102001616	glucose-1-phosphate thymidylyltransferase, short form; Region: rmlA; TIGR01207
195102001617	active site
195102001618	tetramer interface; other site
195102001619	VanZ like family; Region: VanZ; cl01971
195102001620	Alpha-galactosidase [Carbohydrate transport and metabolism]; Region: GalA; COG3345
195102001621	Melibiase; Region: Melibiase; pfam02065
195102001622	Sortase B (SrtB) or subfamily-2 sortases are membrane cysteine transpeptidases found in gram-positive bacteria that anchor surface proteins to peptidoglycans of the bacterial cell wall envelope. This involves a transpeptidation reaction in which the...; Region: Sortase_B_2; cd05826
195102001623	active site
195102001624	catalytic site [active]
195102001625	The S26 Type I signal peptidase (SPase; LepB; leader peptidase B; leader peptidase I; EC 3.4.21.89) family members are essential membrane-bound serine proteases that function to cleave the amino-terminal signal peptide extension from proteins that are...; Region: S26_SPase_I; cd06530
195102001626	Catalytic site [active]
195102001627	alternate signal-mediated exported protein, CPF_0494 family; Region: exp_by_SipW_IV; TIGR04090
195102001628	alternate signal-mediated exported protein, CPF_0494 family; Region: exp_by_SipW_IV; TIGR04090
195102001629	Von Willebrand factor type A (vWA) domain was originally found in the blood coagulation protein von Willebrand factor (vWF). Typically, the vWA domain is made up of approximately 200 amino acid residues folded into a classic a/b para-rossmann type of...; Region: vWFA; cd00198
195102001630	metal ion-dependent adhesion site (MIDAS); other site
195102001631	Response regulator of the LytR/AlgR family [Transcription / Signal transduction mechanisms]; Region: LytT; COG3279
195102001632	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
195102001633	active site
195102001634	phosphorylation site [posttranslational modification]
195102001635	intermolecular recognition site; other site
195102001636	dimerization interface [polypeptide binding]; other site
195102001637	LytTr DNA-binding domain; Region: LytTR; pfam04397
195102001638	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
195102001639	ATP binding site [chemical binding]; other site
195102001640	Mg2+ binding site [ion binding]; other site
195102001641	G-X-G motif; other site
195102001642	SGNH_hydrolase, or GDSL_hydrolase, is a diverse family of lipases and esterases. The tertiary fold of the enzyme is substantially different from that of the alpha/beta hydrolase family and unique among all known hydrolases; its active site closely...; Region: SGNH_hydrolase; cd00229
195102001643	active site
195102001644	catalytic triad [active]
195102001645	oxyanion hole [active]
195102001646	PTS_IIA, PTS system, fructose/mannitol specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_fru; cd00211
195102001647	active site
195102001648	phosphorylation site [posttranslational modification]
195102001649	PTS_IIB_ascorbate: subunit IIB of enzyme II (EII) of the L-ascorbate-specific phosphoenolpyruvate:carbohydrate phosphotransferase system (PTS). In this system, EII is an L-ascorbate-specific permease with two cytoplasmic subunits (IIA and IIB) and a...; Region: PTS_IIB_ascorbate; cd05563
195102001650	active site
195102001651	P-loop; other site
195102001652	phosphorylation site [posttranslational modification]
195102001653	PTS system ascorbate-specific transporter subunit IIC; Reviewed; Region: ulaA; PRK09410
195102001654	Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427
195102001655	haloacid dehalogenase-like hydrolase; Region: Hydrolase_3; pfam08282
195102001656	active site
195102001657	motif I; other site
195102001658	motif II; other site
195102001659	Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427
195102001660	helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347
195102001661	Winged helix DNA-binding domain; Region: HTH_27; pfam13463
195102001662	ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132
195102001663	ABC transporter transmembrane region; Region: ABC_membrane; pfam00664
195102001664	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
195102001665	Walker A/P-loop; other site
195102001666	ATP binding site [chemical binding]; other site
195102001667	Q-loop/lid; other site
195102001668	ABC transporter signature motif; other site
195102001669	Walker B; other site
195102001670	D-loop; other site
195102001671	H-loop/switch region; other site
195102001672	ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132
195102001673	ABC transporter transmembrane region; Region: ABC_membrane; pfam00664
195102001674	ATP-binding cassette domain of glucan transporter and related proteins, subfamily C; Region: ABCC_Glucan_exporter_like; cd03254
195102001675	Walker A/P-loop; other site
195102001676	ATP binding site [chemical binding]; other site
195102001677	Q-loop/lid; other site
195102001678	ABC transporter signature motif; other site
195102001679	Walker B; other site
195102001680	D-loop; other site
195102001681	H-loop/switch region; other site
195102001682	Membrane transport protein; Region: Mem_trans; cl09117
195102001683	(R)-2-Hydroxyglutarate Dehydrogenase and related dehydrogenases, NAD-binding and catalytic domains; Region: HGDH_like; cd12184
195102001684	Lactate dehydrogenase and related dehydrogenases [Energy production and conversion / Coenzyme metabolism / General function prediction only]; Region: LdhA; COG1052
195102001685	putative homodimer interface [polypeptide binding]; other site
195102001686	putative ligand binding site [chemical binding]; other site
195102001687	putative NAD binding site [chemical binding]; other site
195102001688	catalytic site [active]
195102001689	Signal transduction histidine kinase regulating citrate/malate metabolism [Signal transduction mechanisms]; Region: CitA; COG3290
195102001690	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
195102001691	ATP binding site [chemical binding]; other site
195102001692	Mg2+ binding site [ion binding]; other site
195102001693	G-X-G motif; other site
195102001694	Response regulator of citrate/malate metabolism [Transcription / Signal transduction mechanisms]; Region: CitB; COG4565
195102001695	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
195102001696	active site
195102001697	phosphorylation site [posttranslational modification]
195102001698	intermolecular recognition site; other site
195102001699	dimerization interface [polypeptide binding]; other site
195102001700	Predicted membrane protein [Function unknown]; Region: COG1971
195102001701	Domain of unknown function DUF; Region: DUF204; pfam02659
195102001702	Domain of unknown function DUF; Region: DUF204; pfam02659
195102001703	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG0675
195102001704	Helix-turn-helix domain; Region: HTH_OrfB_IS605; pfam12323
195102001705	Probable transposase; Region: OrfB_IS605; pfam01385
195102001706	Putative transposase DNA-binding domain; Region: OrfB_Zn_ribbon; pfam07282
195102001707	Alcohol dehydrogenase, class IV [Energy production and conversion]; Region: EutG; COG1454
195102001708	Dehydroquinate synthase-like (DHQ-like) and iron-containing alcohol dehydrogenases (Fe-ADH); Region: DHQ_Fe-ADH; cl02872
195102001709	active site
195102001710	NAD binding site [chemical binding]; other site
195102001711	metal binding site [ion binding]; metal-binding site
195102001712	TrkA-C domain; Region: TrkA_C; pfam02080
195102001713	Transcriptional regulators [Transcription]; Region: MarR; COG1846
195102001714	MarR family; Region: MarR_2; pfam12802
195102001715	Predicted permease, member of the PurR regulon [General function prediction only]; Region: yhhT; COG0628
195102001716	Domain of unknown function DUF20; Region: UPF0118; pfam01594
195102001717	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
195102001718	putative substrate translocation pore; other site
195102001719	POT family; Region: PTR2; cl17359
195102001720	Sulfite reductase, beta subunit (hemoprotein) [Inorganic ion transport and metabolism]; Region: CysI; COG0155
195102001721	Nitrite/Sulfite reductase ferredoxin-like half domain; Region: NIR_SIR_ferr; pfam03460
195102001722	S-adenosylmethionine decarboxylase; Provisional; Region: PRK05462
195102001723	Arginine/lysine/ornithine decarboxylases [Amino acid transport and metabolism]; Region: LdcC; COG1982
195102001724	Ornithine decarboxylase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD corresponds to ornithine decarboxylase (ODC), arginine decarboxylase (ADC) and lysine...; Region: Orn_deC_like; cd00615
195102001725	homodimer interface [polypeptide binding]; other site
195102001726	pyridoxal 5'-phosphate binding site [chemical binding]; other site
195102001727	catalytic residue [active]
195102001728	Orn/Lys/Arg decarboxylase, C-terminal domain; Region: OKR_DC_1_C; pfam03711
195102001729	spermidine synthase; Provisional; Region: PRK00811
195102001730	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
195102001731	S-adenosylmethionine binding site [chemical binding]; other site
195102001732	agmatinase; Region: agmatinase; TIGR01230
195102001733	Agmatinase and related proteins; Region: Agmatinase-like_2; cd11593
195102001734	putative active site [active]
195102001735	Mn binding site [ion binding]; other site
195102001736	Protein of unknown function (DUF1294); Region: DUF1294; pfam06961
195102001737	F5/8 type C domain; Region: F5_F8_type_C; pfam00754
195102001738	sugar binding site [chemical binding]; other site
195102001739	Pentraxins are plasma proteins characterized by their pentameric discoid assembly and their Ca2+ dependent ligand binding, such as Serum amyloid P component (SAP) and C-reactive Protein (CRP), which are cytokine-inducible acute-phase proteins implicated...; Region: PTX; cl00102
195102001740	Sialidases or neuraminidases function to bind and hydrolyze terminal sialic acid residues from various glycoconjugates as well as playing roles in pathogenesis, bacterial nutrition and cellular interactions. They have a six-bladed, beta-propeller fold...; Region: Sialidase; cd00260
195102001741	Asp-box motif; other site
195102001742	catalytic site [active]
195102001743	Type II cohesin domain, interaction partner of dockerin; Region: Type_II_cohesin; cd08547
195102001744	dockerin binding interface; other site
195102001745	Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all...; Region: FN3; cd00063
195102001746	Interdomain contacts; other site
195102001747	Cytokine receptor motif; other site
195102001748	Cation transport ATPase [Inorganic ion transport and metabolism]; Region: ZntA; COG2217
195102001749	Heavy-metal-associated domain (HMA) is a conserved domain of approximately 30 amino acid residues found in a number of proteins that transport or detoxify heavy metals, for example, the CPx-type heavy metal ATPases and copper chaperones. HMA domain...; Region: HMA; cd00371
195102001750	metal-binding site [ion binding]
195102001751	Cation transport ATPase [Inorganic ion transport and metabolism]; Region: ZntA; COG2217
195102001752	Heavy-metal-associated domain (HMA) is a conserved domain of approximately 30 amino acid residues found in a number of proteins that transport or detoxify heavy metals, for example, the CPx-type heavy metal ATPases and copper chaperones. HMA domain...; Region: HMA; cd00371
195102001753	metal-binding site [ion binding]
195102001754	Cation transport ATPase [Inorganic ion transport and metabolism]; Region: ZntA; COG2217
195102001755	Heavy-metal-associated domain (HMA) is a conserved domain of approximately 30 amino acid residues found in a number of proteins that transport or detoxify heavy metals, for example, the CPx-type heavy metal ATPases and copper chaperones. HMA domain...; Region: HMA; cd00371
195102001756	metal-binding site [ion binding]
195102001757	The Tellurite-resistance/Dicarboxylate Transporter (TDT) family; Region: TDT; cl04176
195102001758	E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122
195102001759	Soluble P-type ATPase [General function prediction only]; Region: COG4087
195102001760	Flavodoxin-like fold; Region: Flavodoxin_2; cl00438
195102001761	ABC-type proline/glycine betaine transport systems, ATPase components [Amino acid transport and metabolism]; Region: OpuBA; COG1125
195102001762	ATP-binding cassette domain of the osmoprotectant transporter; Region: ABC_OpuCA_Osmoprotection; cd03295
195102001763	Walker A/P-loop; other site
195102001764	ATP binding site [chemical binding]; other site
195102001765	Q-loop/lid; other site
195102001766	ABC transporter signature motif; other site
195102001767	Walker B; other site
195102001768	D-loop; other site
195102001769	H-loop/switch region; other site
195102001770	FOG: CBS domain [General function prediction only]; Region: COG0517
195102001771	This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains in association with the ABC transporter OpuCA. OpuCA is the ATP binding component of a bacterial solute transporter that serves a protective role to cells growing...; Region: CBS_pair_ABC_OpuCA_assoc2; cd04583
195102001772	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
195102001773	dimer interface [polypeptide binding]; other site
195102001774	conserved gate region; other site
195102001775	putative PBP binding loops; other site
195102001776	ABC-ATPase subunit interface; other site
195102001777	Periplasmic glycine betaine/choline-binding (lipo)protein of an ABC-type transport system (osmoprotectant binding protein) [Cell envelope biogenesis, outer membrane]; Region: OpuBC; COG1732
195102001778	ABC-type proline/glycine betaine transport systems, periplasmic components [Amino acid transport and metabolism]; Region: ProX; cl17891
195102001779	RNA polymerase sigma-70 factor, TIGR02954 family; Region: Sig70_famx3
195102001780	Sigma-70 region 2; Region: Sigma70_r2; pfam04542
195102001781	Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171
195102001782	DNA binding residues [nucleotide binding]
195102001783	Domain of unknown function (DUF4179); Region: DUF4179; pfam13786
195102001784	PTS system, trehalose-specific IIBC component; Region: PTS-IIBC-Tre; TIGR01992
195102001785	PTS_IIB, PTS system, glucose/sucrose specific IIB subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIB_glc; cd00212
195102001786	active site turn [active]
195102001787	phosphorylation site [posttranslational modification]
195102001788	Phosphotransferase system IIC components, glucose/maltose/N-acetylglucosamine-specific [Carbohydrate transport and metabolism]; Region: PtsG; COG1263
195102001789	alpha,alpha-phosphotrehalase; Region: trehalose_treC; TIGR02403
195102001790	Alpha amylase catalytic domain found in Sucrose isomerases, oligo-1,6-glucosidase (also called isomaltase; sucrase-isomaltase; alpha-limit dextrinase), dextran glucosidase (also called glucan 1,6-alpha-glucosidase), and related proteins; Region: AmyAc_SI_OligoGlu_DGase; cd11333
195102001791	Ca binding site [ion binding]; other site
195102001792	active site
195102001793	catalytic site [active]
195102001794	Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377
195102001795	DNA-binding site [nucleotide binding]; DNA binding site
195102001796	trehalose operon repressor, B. subtilis-type; Region: trehalos_R_Bsub; TIGR02404
195102001797	UTRA domain; Region: UTRA; pfam07702
195102001798	stage V sporulation protein D; Region: spoVD_pbp; TIGR02214
195102001799	Penicillin-binding Protein dimerisation domain; Region: PBP_dimer; pfam03717
195102001800	Penicillin binding protein transpeptidase domain; Region: Transpeptidase; pfam00905
195102001801	PASTA domain of PBP2x-like proteins, first repeat. Penicillin-binding proteins (PBPs) are the major targets for beta-lactam antibiotics, like penicillins and cephalosporins. Beta-lactam antibiotics specifically inhibit transpeptidase activity by...; Region: PASTA_Pbp2x-like_1; cd06576
195102001802	PASTA domain of PBP2x-like proteins, second repeat. Penicillin-binding proteins (PBPs) are the major targets for beta-lactam antibiotics, like penicillins and cephalosporins. Beta-lactam antibiotics specifically inhibit transpeptidase activity by...; Region: PASTA_Pbp2x-like_2; cd06575
195102001803	Peptidoglycan recognition proteins (PGRPs) are pattern recognition receptors that bind, and in certain cases, hydrolyze peptidoglycans (PGNs) of bacterial cell walls. PGRPs have been divided into three classes: short PGRPs (PGRP-S), that are small (20...; Region: PGRP; cd06583
195102001804	amidase catalytic site [active]
195102001805	Zn binding residues [ion binding]; other site
195102001806	substrate binding site [chemical binding]; other site
195102001807	riboflavin biosynthesis protein RibD; Region: eubact_ribD; TIGR00326
195102001808	Riboflavin-specific deaminase. Riboflavin biosynthesis protein RibD (Diaminohydroxyphosphoribosylaminopyrimidine deaminase) catalyzes the deamination of 2,5-diamino-6-ribosylamino-4(3H)-pyrimidinone 5'-phosphate, which is an intermediate step in the...; Region: Riboflavin_deaminase-reductase; cd01284
195102001809	catalytic motif [active]
195102001810	Zn binding site [ion binding]; other site
195102001811	RibD C-terminal domain; Region: RibD_C; cl17279
195102001812	riboflavin synthase subunit alpha; Provisional; Region: PRK09289
195102001813	Lumazine binding domain; Region: Lum_binding; pfam00677
195102001814	Lumazine binding domain; Region: Lum_binding; pfam00677
195102001815	bifunctional 3,4-dihydroxy-2-butanone 4-phosphate synthase/GTP cyclohydrolase II protein; Provisional; Region: PRK09311
195102001816	3,4-dihydroxy-2-butanone 4-phosphate synthase; Region: DHBP_synthase; pfam00926
195102001817	GTP cyclohydrolase II (RibA).  GTP cyclohydrolase II catalyzes the conversion of GTP to 2,5-diamino-6-ribosylamino-4(3H)-pyrimidinone 5' phosphate, formate, pyrophosphate (APy), and GMP in the biosynthetic pathway of riboflavin. Riboflavin is the...; Region: GTP_cyclohydro2; cd00641
195102001818	dimerization interface [polypeptide binding]; other site
195102001819	active site
195102001820	lumazine synthase (6,7-dimethyl-8-ribityllumazine synthase, LS), catalyzes the penultimate step in the biosynthesis of riboflavin (vitamin B2); type-I; Region: Lumazine_synthase-I; cd09209
195102001821	homopentamer interface [polypeptide binding]; other site
195102001822	active site
195102001823	glucan-binding repeat; Region: glucan_65_rpt; TIGR04035
195102001824	Putative cell wall binding repeat; Region: CW_binding_1; pfam01473
195102001825	glucan-binding repeat; Region: glucan_65_rpt; TIGR04035
195102001826	Uncharacterized protein family UPF0047; Region: UPF0047; pfam01894
195102001827	RNA recognition motif (RRM) superfamily; Region: RRM_SF; cl17169
195102001828	1,3-beta-galactosyl-N-acetylhexosamine phosphorylase; Region: TIGR02336
195102001829	Lacto-N-biose phosphorylase; Region: Lact_bio_phlase; pfam09508
195102001830	Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642
195102001831	Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225
195102001832	dimerization interface [polypeptide binding]; other site
195102001833	Histidine kinase; Region: His_kinase; pfam06580
195102001834	Histidine kinase-like ATPases; Region: HATPase_c; smart00387
195102001835	ATP binding site [chemical binding]; other site
195102001836	Mg2+ binding site [ion binding]; other site
195102001837	G-X-G motif; other site
195102001838	Response regulator receiver domain; Region: Response_reg; pfam00072
195102001839	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
195102001840	active site
195102001841	phosphorylation site [posttranslational modification]
195102001842	intermolecular recognition site; other site
195102001843	dimerization interface [polypeptide binding]; other site
195102001844	Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165
195102001845	helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342
195102001846	Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165
195102001847	carbohydrate ABC transporter substrate-binding protein, CPR_0540 family; Region: bind_CPR_0540; TIGR03850
195102001848	Bacterial extracellular solute-binding protein; Region: SBP_bac_1; pfam01547
195102001849	ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395
195102001850	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
195102001851	dimer interface [polypeptide binding]; other site
195102001852	conserved gate region; other site
195102001853	putative PBP binding loops; other site
195102001854	ABC-ATPase subunit interface; other site
195102001855	ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395
195102001856	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
195102001857	dimer interface [polypeptide binding]; other site
195102001858	conserved gate region; other site
195102001859	putative PBP binding loops; other site
195102001860	ABC-ATPase subunit interface; other site
195102001861	Uncharacterized conserved protein [Function unknown]; Region: COG0398
195102001862	SNARE associated Golgi protein; Region: SNARE_assoc; pfam09335
195102001863	The HCP family of iron-sulfur proteins includes hybrid cluster protein (HCP), acetyl-CoA synthase (ACS), and carbon monoxide dehydrogenase (CODH), all of which contain [Fe4-S4] metal clusters at their active sites. These proteins have a conserved...; Region: HCP_like; cl14655
195102001864	Fe-S oxidoreductase [Energy production and conversion]; Region: GlpC; COG0247
195102001865	Cysteine-rich domain; Region: CCG; pfam02754
195102001866	CDP-alcohol phosphatidyltransferase; Region: CDP-OH_P_transf; pfam01066
195102001867	Phosphate transport regulator (distant homolog of PhoU) [Inorganic ion transport and metabolism]; Region: COG1392
195102001868	Phosphate/sulphate permeases [Inorganic ion transport and metabolism]; Region: PitA; COG0306
195102001869	PTS system 2-O-a-mannosyl-D-glycerate specific transporter subunit IIABC; Provisional; Region: PRK09765
195102001870	PTS_IIA, PTS system, fructose/mannitol specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_fru; cd00211
195102001871	active site
195102001872	phosphorylation site [posttranslational modification]
195102001873	PTS_IIB_fructose: subunit IIB of enzyme II (EII) of the fructose-specific phosphoenolpyruvate:carbohydrate phosphotransferase system (PTS). In this system, EII (also referred to as FruAB) is a fructose-specific permease made up of two proteins (FruA and...; Region: PTS_IIB_fructose; cd05569
195102001874	active site
195102001875	P-loop; other site
195102001876	phosphorylation site [posttranslational modification]
195102001877	PTS system, fructose subfamily, IIC component; Region: PTS_IIC_fructo; TIGR01427
195102001878	Fructose-1-phosphate kinase and related fructose-6-phosphate kinase (PfkB) [Carbohydrate transport and metabolism]; Region: FruK; COG1105
195102001879	1-phosphofructokinase (FruK), minor 6-phosphofructokinase (pfkB) and related sugar kinases. FruK plays an important role in the predominant pathway for fructose utilisation.This group also contains tagatose-6-phophate kinase, an enzyme of the tagatose...; Region: FruK_PfkB_like; cd01164
195102001880	putative substrate binding site [chemical binding]; other site
195102001881	putative ATP binding site [chemical binding]; other site
195102001882	Transcriptional regulators of sugar metabolism [Transcription / Carbohydrate transport and metabolism]; Region: GlpR; COG1349
195102001883	helix_turn_helix, Deoxyribose operon repressor; Region: HTH_DEOR; smart00420
195102001884	DeoR C terminal sensor domain; Region: DeoRC; pfam00455
195102001885	Predicted permease, member of the PurR regulon [General function prediction only]; Region: yhhT; COG0628
195102001886	Domain of unknown function DUF20; Region: UPF0118; pfam01594
195102001887	Isochorismatase family; Region: Isochorismatase; pfam00857
195102001888	Cysteine hydrolases; This family contains amidohydrolases, like CSHase (N-carbamoylsarcosine amidohydrolase), involved in creatine metabolism and nicotinamidase, converting nicotinamide to nicotinic acid and ammonia in the pyridine nucleotide cycle. It...; Region: cysteine_hydrolases; cd00431
195102001889	catalytic triad [active]
195102001890	conserved cis-peptide bond; other site
195102001891	ClC sycA-like chloride channel proteins. This ClC family presents in bacteria, where it facilitates acid resistance in acidic soil. Mutation of this gene (sycA) in Rhizobium tropici CIAT899 causes serious deficiencies in nodule development, nodulation...; Region: ClC_sycA_like; cd03682
195102001892	Chloride channel protein EriC [Inorganic ion transport and metabolism]; Region: EriC; COG0038
195102001893	putative Cl- selectivity filter; other site
195102001894	putative pore gating glutamate residue; other site
195102001895	glutaminase A; Region: Gln_ase; TIGR03814
195102001896	Glutaminase [Amino acid transport and metabolism]; Region: GlsA; COG2066
195102001897	Uncharacterized membrane protein [Function unknown]; Region: SapB; COG1285
195102001898	MgtC family; Region: MgtC; pfam02308
195102001899	putative DNA-binding transcriptional regulator; Reviewed; Region: PRK00347
195102001900	NADH pyrophosphatase, a member of the Nudix hydrolase superfamily, catalyzes the cleavage of NADH into reduced nicotinamide mononucleotide (NMNH) and AMP. Like other members of the Nudix family, it requires a divalent cation, such as Mg2+ or Mn2+, for...; Region: NADH_pyrophosphatase; cd03429
195102001901	putative NADH binding site [chemical binding]; other site
195102001902	putative active site [active]
195102001903	nudix motif; other site
195102001904	putative metal binding site [ion binding]; other site
195102001905	diaminopimelate decarboxylase; Region: lysA; TIGR01048
195102001906	Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzyme Diaminopimelate Decarboxylase; Region: PLPDE_III_DapDC; cd06828
195102001907	active site
195102001908	pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site
195102001909	substrate binding site [chemical binding]; other site
195102001910	catalytic residues [active]
195102001911	dimer interface [polypeptide binding]; other site
195102001912	Protein of unknown function (DUF3006); Region: DUF3006; pfam11213
195102001913	signal peptidase I, bacterial type; Region: sigpep_I_bact; TIGR02227
195102001914	The S26 Type I signal peptidase (SPase; LepB; leader peptidase B; leader peptidase I; EC 3.4.21.89) family members are essential membrane-bound serine proteases that function to cleave the amino-terminal signal peptide extension from proteins that are...; Region: S26_SPase_I; cd06530
195102001915	Catalytic site [active]
195102001916	FtsH Extracellular; Region: FtsH_ext; pfam06480
195102001917	ATP-dependent metalloprotease FtsH; Region: FtsH_fam; TIGR01241
195102001918	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
195102001919	Walker A motif; other site
195102001920	ATP binding site [chemical binding]; other site
195102001921	Walker B motif; other site
195102001922	arginine finger; other site
195102001923	Peptidase family M41; Region: Peptidase_M41; pfam01434
195102001924	Superfamily I DNA and RNA helicases [General function prediction only]; Region: COG3973
195102001925	Part of AAA domain; Region: AAA_19; pfam13245
195102001926	Family description; Region: UvrD_C_2; pfam13538
195102001927	Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of  substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134
195102001928	Bacterial extracellular solute-binding proteins, family 3; Region: SBP_bac_3; pfam00497
195102001929	substrate binding pocket [chemical binding]; other site
195102001930	membrane-bound complex binding site; other site
195102001931	hinge residues; other site
195102001932	ABC-type arginine transport system, permease component [Amino acid transport and metabolism]; Region: ArtQ; COG4215
195102001933	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
195102001934	dimer interface [polypeptide binding]; other site
195102001935	conserved gate region; other site
195102001936	putative PBP binding loops; other site
195102001937	ABC-ATPase subunit interface; other site
195102001938	ABC-type polar amino acid transport system, ATPase component [Amino acid transport and metabolism]; Region: GlnQ; COG1126
195102001939	ATP-binding cassette domain of the histidine and glutamine transporters; Region: ABC_HisP_GlnQ; cd03262
195102001940	Walker A/P-loop; other site
195102001941	ATP binding site [chemical binding]; other site
195102001942	Q-loop/lid; other site
195102001943	ABC transporter signature motif; other site
195102001944	Walker B; other site
195102001945	D-loop; other site
195102001946	H-loop/switch region; other site
195102001947	Phosphoglycerol transferase and related proteins, alkaline phosphatase superfamily [Cell envelope biogenesis, outer membrane]; Region: MdoB; COG1368
195102001948	Sulfatase; Region: Sulfatase; cl17466
195102001949	Phosphoglycerol transferase and related proteins, alkaline phosphatase superfamily [Cell envelope biogenesis, outer membrane]; Region: MdoB; COG1368
195102001950	Sulfatase; Region: Sulfatase; cl17466
195102001951	Predicted Co/Zn/Cd cation transporters [Inorganic ion transport and metabolism]; Region: MMT1; COG0053
195102001952	cation diffusion facilitator family transporter; Region: CDF; TIGR01297
195102001953	Peptidoglycan recognition proteins (PGRPs) are pattern recognition receptors that bind, and in certain cases, hydrolyze peptidoglycans (PGNs) of bacterial cell walls. PGRPs have been divided into three classes: short PGRPs (PGRP-S), that are small (20...; Region: PGRP; cd06583
195102001954	amidase catalytic site [active]
195102001955	Zn binding residues [ion binding]; other site
195102001956	substrate binding site [chemical binding]; other site
195102001957	Bacterial SH3 domain; Region: SH3_3; pfam08239
195102001958	Bacterial SH3 domain; Region: SH3_3; pfam08239
195102001959	Bacterial SH3 domain; Region: SH3_3; pfam08239
195102001960	Bacterial SH3 domain; Region: SH3_3; pfam08239
195102001961	Bacterial SH3 domain; Region: SH3_3; pfam08239
195102001962	M18 Peptidase Aspartyl aminopeptidase; Region: M18_DAP; cd05658
195102001963	Aminopeptidase I zinc metalloprotease (M18); Region: Peptidase_M18; pfam02127
195102001964	active site
195102001965	metal binding site [ion binding]; metal-binding site
195102001966	Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427
195102001967	haloacid dehalogenase-like hydrolase; Region: Hydrolase_3; pfam08282
195102001968	active site
195102001969	motif I; other site
195102001970	motif II; other site
195102001971	Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427
195102001972	haloacid dehalogenase-like hydrolase; Region: HAD; cl17202
195102001973	MMPL family; Region: MMPL; pfam03176
195102001974	Predicted drug exporters of the RND superfamily [General function prediction only]; Region: COG2409
195102001975	Carbon starvation protein CstA; Region: CstA; pfam02554
195102001976	peptide chain release factor 3; Provisional; Region: prfC; PRK00741
195102001977	Release Factor 3 (RF3) protein involved in the terminal step of translocation in bacteria; Region: RF3; cd04169
195102001978	G1 box; other site
195102001979	putative GEF interaction site [polypeptide binding]; other site
195102001980	GTP/Mg2+ binding site [chemical binding]; other site
195102001981	Switch I region; other site
195102001982	G2 box; other site
195102001983	G3 box; other site
195102001984	Switch II region; other site
195102001985	G4 box; other site
195102001986	G5 box; other site
195102001987	RF3_II: this subfamily represents the domain II of bacterial Release Factor 3 (RF3). Termination of protein synthesis by the ribosome requires two release factor (RF) classes. The class II RF3 is a GTPase that removes class I RFs (RF1 or RF2) from the...; Region: RF3_II; cd03689
195102001988	Predicted ATPase/kinase involved in NAD metabolism [Coenzyme metabolism]; Region: NadR; COG3172
195102001989	AAA domain; Region: AAA_28; pfam13521
195102001990	sugar phosphate phosphatase; Provisional; Region: PRK10513
195102001991	Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427
195102001992	active site
195102001993	motif I; other site
195102001994	motif II; other site
195102001995	Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427
195102001996	exopolysaccharide biosynthesis polyprenyl glycosylphosphotransferase; Region: EPS_sugtrans; TIGR03025
195102001997	Bacterial sugar transferase; Region: Bac_transf; pfam02397
195102001998	Glycosyltransferases involved in cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WcaA; COG0463
195102001999	Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394
195102002000	active site
195102002001	G1P_TT_short is the short form of glucose-1-phosphate thymidylyltransferase; Region: G1P_TT_short; cd02538
195102002002	glucose-1-phosphate thymidylyltransferase, short form; Region: rmlA; TIGR01207
195102002003	substrate binding site; other site
195102002004	tetramer interface; other site
195102002005	dTDP-4-dehydrorhamnose 3,5-epimerase; Region: dTDP_sugar_isom; cl17405
195102002006	dTDP-4-dehydrorhamnose reductase [Cell envelope biogenesis, outer membrane]; Region: RfbD; COG1091
195102002007	dTDP-6-deoxy-L-lyxo-4-hexulose reductase and related proteins, extended (e) SDRs; Region: dTDP_HR_like_SDR_e; cd05254
195102002008	NADP binding site [chemical binding]; other site
195102002009	active site
195102002010	putative substrate binding site [chemical binding]; other site
195102002011	dTDP-D-glucose 4,6-dehydratase [Cell envelope biogenesis, outer membrane]; Region: RfbB; COG1088
195102002012	dTDP-D-glucose 4,6-dehydratase, extended (e) SDRs; Region: dTDP_GD_SDR_e; cd05246
195102002013	NAD binding site [chemical binding]; other site
195102002014	substrate binding site [chemical binding]; other site
195102002015	homodimer interface [polypeptide binding]; other site
195102002016	active site
195102002017	O-Antigen ligase; Region: Wzy_C; pfam04932
195102002018	Glycosyltransferase like family 2; Region: Glyco_tranf_2_3; pfam13641
195102002019	Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cd00761
195102002020	active site
195102002021	LicD family; Region: LicD; pfam04991
195102002022	Membrane protein involved in the export of O-antigen and teichoic acid [General function prediction only]; Region: RfbX; COG2244
195102002023	Wzx, a subfamily of the multidrug and toxic compound extrusion (MATE)-like proteins; Region: MATE_Wzx_like; cd13128
195102002024	Mannosyl-glycoprotein endo-beta-N-acetylglucosaminidase; Region: Glucosaminidase; pfam01832
195102002025	FOG: Glucan-binding domain (YG repeat) [General function prediction only]; Region: COG5263
195102002026	Putative cell wall binding repeat; Region: CW_binding_1; pfam01473
195102002027	FOG: Glucan-binding domain (YG repeat) [General function prediction only]; Region: COG5263
195102002028	Putative cell wall binding repeat; Region: CW_binding_1; pfam01473
195102002029	glucan-binding repeat; Region: glucan_65_rpt; TIGR04035
195102002030	M14 family of metallocarboxypeptidases and related proteins; Region: Peptidase_M14_like; cl11393
195102002031	active site
195102002032	Zn binding site [ion binding]; other site
195102002033	FOG: Glucan-binding domain (YG repeat) [General function prediction only]; Region: COG5263
195102002034	Putative cell wall binding repeat; Region: CW_binding_1; pfam01473
195102002035	Putative cell wall binding repeat; Region: CW_binding_1; pfam01473
195102002036	glucan-binding repeat; Region: glucan_65_rpt; TIGR04035
195102002037	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3786
195102002038	Winged helix-turn-helix DNA-binding; Region: HTH_24; pfam13412
195102002039	Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394
195102002040	active site
195102002041	Choline Kinase (ChoK). The ChoK subfamily is part of a larger superfamily that includes the catalytic domains of other kinases, such as the typical serine/threonine/tyrosine protein kinases (PKs), RIO kinases, actin-fragmin kinase (AFK), and...; Region: ChoK; cd05151
195102002042	active site
195102002043	ATP binding site [chemical binding]; other site
195102002044	Phosphotransferase enzyme family; Region: APH; pfam01636
195102002045	substrate binding site [chemical binding]; other site
195102002046	dimer interface [polypeptide binding]; other site
195102002047	Permeases of the drug/metabolite transporter (DMT) superfamily [Carbohydrate transport and metabolism / Amino acid transport and metabolism / General function prediction only]; Region: RhaT; COG0697
195102002048	Multidrug resistance efflux transporter; Region: EmrE; pfam13536
195102002049	EamA-like transporter family; Region: EamA; cl17759
195102002050	Nucleoside-diphosphate-sugar pyrophosphorylase involved in lipopolysaccharide biosynthesis/translation initiation factor 2B, gamma/epsilon subunits (eIF-2Bgamma/eIF-2Bepsilon) [Cell envelope biogenesis, outer membrane / Translation, ribosomal structure...; Region: GCD1; COG1208
195102002051	Phosphocholine cytidylyltransferases catalyze the synthesis of CDP-choline; Region: PC_cytidylyltransferase; cd02523
195102002052	active site
195102002053	metal-binding site
195102002054	glucan-binding repeat; Region: glucan_65_rpt; TIGR04035
195102002055	glucan-binding repeat; Region: glucan_65_rpt; TIGR04035
195102002056	glucan-binding repeat; Region: glucan_65_rpt; TIGR04035
195102002057	Putative cell wall binding repeat; Region: CW_binding_1; pfam01473
195102002058	glucan-binding repeat; Region: glucan_65_rpt; TIGR04035
195102002059	Transcriptional regulator [Transcription]; Region: LytR; COG1316
195102002060	Branched-chain amino acid transport protein; Region: Branch_AA_trans; pfam05525
195102002061	tryptophanyl-tRNA synthetase II; Reviewed; Region: PRK12282
195102002062	catalytic core domain of tryptophanyl-tRNA synthetase; Region: TrpRS_core; cd00806
195102002063	active site
195102002064	HIGH motif; other site
195102002065	dimer interface [polypeptide binding]; other site
195102002066	KMSKS motif; other site
195102002067	anaerobic sulfatase-maturase; Provisional; Region: PRK13758
195102002068	Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335
195102002069	FeS/SAM binding site; other site
195102002070	radical SAM additional 4Fe4S-binding SPASM domain; Region: rSAM_more_4Fe4S; TIGR04085
195102002071	PBP superfamily domain; Region: PBP_like_2; cl17296
195102002072	Bacterial extracellular solute-binding protein; Region: SBP_bac_11; pfam13531
195102002073	PBP superfamily domain; Region: PBP_like_2; cl17296
195102002074	Bacterial extracellular solute-binding protein; Region: SBP_bac_11; pfam13531
195102002075	ABC-type phosphate transport system, permease component [Inorganic ion transport and metabolism]; Region: PstC; COG0573
195102002076	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
195102002077	dimer interface [polypeptide binding]; other site
195102002078	conserved gate region; other site
195102002079	putative PBP binding loops; other site
195102002080	ABC-ATPase subunit interface; other site
195102002081	ABC-type phosphate transport system, permease component [Inorganic ion transport and metabolism]; Region: PstA; COG0581
195102002082	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
195102002083	dimer interface [polypeptide binding]; other site
195102002084	conserved gate region; other site
195102002085	putative PBP binding loops; other site
195102002086	ABC-ATPase subunit interface; other site
195102002087	phosphate transporter ATP-binding protein; Provisional; Region: PRK14240
195102002088	ATP-binding cassette domain of the phosphate transport system; Region: ABC_PstB_phosphate_transporter; cd03260
195102002089	Walker A/P-loop; other site
195102002090	ATP binding site [chemical binding]; other site
195102002091	Q-loop/lid; other site
195102002092	ABC transporter signature motif; other site
195102002093	Walker B; other site
195102002094	D-loop; other site
195102002095	H-loop/switch region; other site
195102002096	phosphate transport system regulatory protein PhoU; Region: phoU_full; TIGR02135
195102002097	PhoU domain; Region: PhoU; pfam01895
195102002098	PhoU domain; Region: PhoU; pfam01895
195102002099	Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745
195102002100	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
195102002101	active site
195102002102	phosphorylation site [posttranslational modification]
195102002103	intermolecular recognition site; other site
195102002104	dimerization interface [polypeptide binding]; other site
195102002105	Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383
195102002106	DNA binding site [nucleotide binding]
195102002107	Protein of unknown function (DUF3793); Region: DUF3793; pfam12672
195102002108	flavodoxin; Provisional; Region: PRK05568
195102002109	Uncharacterized flavoproteins [Energy production and conversion]; Region: FpaA; COG0426
195102002110	glutaminyl-tRNA synthetase; Provisional; Region: PRK05347
195102002111	nucleotidyl transferase superfamily; Region: nt_trans; cl00015
195102002112	active site
195102002113	HIGH motif; other site
195102002114	nucleotide binding site [chemical binding]; other site
195102002115	catalytic core domain of glutaminyl-tRNA synthetase; Region: GlnRS_core; cd00807
195102002116	KMSKS motif; other site
195102002117	tRNA synthetases class I (E and Q), anti-codon binding domain; Region: tRNA-synt_1c_C; pfam03950
195102002118	Probable zinc-binding domain; Region: zf-trcl; pfam13451
195102002119	Spore germination protein; Region: Spore_permease; cl17796
195102002120	Bacillus/Clostridium GerA spore germination protein; Region: GerA; pfam03323
195102002121	germination protein, Ger(x)C family; Region: spore_ger_x_C; TIGR02887
195102002122	Spore germination B3/ GerAC like, C-terminal; Region: Spore_GerAC; pfam05504
195102002123	Predicted transcriptional regulator containing an HTH domain and an uncharacterized domain shared with the mammalian protein Schlafen [Transcription]; Region: COG2865
195102002124	Divergent AAA domain; Region: AAA_4; pfam04326
195102002125	ATPases associated with a variety of cellular activities; Region: AAA; smart00382
195102002126	tyrosyl-tRNA synthetase; Validated; Region: PRK05912
195102002127	catalytic core domain of tyrosinyl-tRNA synthetase; Region: TyrRS_core; cd00805
195102002128	active site
195102002129	HIGH motif; other site
195102002130	dimer interface [polypeptide binding]; other site
195102002131	KMSKS motif; other site
195102002132	S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site;  Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165
195102002133	RNA binding surface [nucleotide binding]; other site
195102002134	Deinococcus radiodurans DR1119 and related proteins, metallophosphatase domain; Region: MPP_DR1119; cd07393
195102002135	Calcineurin-like phosphoesterase; Region: Metallophos; pfam00149
195102002136	putative active site [active]
195102002137	putative metal binding site [ion binding]; other site
195102002138	Nucleotidyltransferase (NT) domain of RelA- and SpoT-like ppGpp synthetases and hydrolases; Region: NT_Rel-Spo_like; cd05399
195102002139	synthetase active site [active]
195102002140	NTP binding site [chemical binding]; other site
195102002141	metal binding site [ion binding]; metal-binding site
195102002142	Domain of unknown function (DUF4116); Region: DUF4116; pfam13475
195102002143	ATPases associated with a variety of cellular activities; Region: AAA; smart00382
195102002144	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
195102002145	Walker A motif; other site
195102002146	ATP binding site [chemical binding]; other site
195102002147	Walker B motif; other site
195102002148	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3864
195102002149	Putative metallopeptidase domain; Region: DUF2201_N; pfam13203
195102002150	Von Willebrand factor type A (vWA) domain was originally found in the blood coagulation protein von Willebrand factor (vWF). Typically, the vWA domain is made up of approximately 200 amino acid residues folded into a classic a/b para-rossmann type of...; Region: vWFA; cl00057
195102002151	Putative NodB-like catalytic domain of uncharacterized proteins found in bacteria; Region: CE4_COG5298; cd10923
195102002152	Uncharacterized protein conserved in bacteria (DUF2334); Region: DUF2334; pfam10096
195102002153	NodB motif; other site
195102002154	putative active site [active]
195102002155	putative catalytic site [active]
195102002156	putative Zn binding site [ion binding]; other site
195102002157	glycine radical enzyme, YjjI family; Region: glycyl_YjjI; TIGR04040
195102002158	Pyruvate formate lyase; Region: PFL; pfam02901
195102002159	Ribonucleotide reductase and Pyruvate formate lyase; Region: RNR_PFL; cl09939
195102002160	glycine radical enzyme activase, YjjW family; Region: activase_YjjW; TIGR04041
195102002161	Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cl15377
195102002162	FeS/SAM binding site; other site
195102002163	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
195102002164	TPR motif; other site
195102002165	binding surface
195102002166	Tetratricopeptide repeat; Region: TPR_12; pfam13424
195102002167	Alpha-L-fucosidase [Carbohydrate transport and metabolism]; Region: COG3669
195102002168	Alpha-L-fucosidase; Region: Alpha_L_fucos; cl12119
195102002169	F5/8 type C domain; Region: F5_F8_type_C; pfam00754
195102002170	HesB-like selenoprotein; Region: HesB_rel_seleno; TIGR01911
195102002171	Transposase IS200 like; Region: Y1_Tnp; pfam01797
195102002172	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG0675
195102002173	Helix-turn-helix domain; Region: HTH_OrfB_IS605; pfam12323
195102002174	Probable transposase; Region: OrfB_IS605; pfam01385
195102002175	transposase, IS605 OrfB family, central region; Region: tspaseT_teng_C; TIGR01766
195102002176	Putative transposase DNA-binding domain; Region: OrfB_Zn_ribbon; pfam07282
195102002177	leucyl-tRNA synthetase; Validated; Region: leuS; PRK00390
195102002178	catalytic core domain of leucyl-tRNA synthetases; Region: LeuRS_core; cd00812
195102002179	HIGH motif; other site
195102002180	Leucyl-tRNA synthetase, Domain 2; Region: tRNA-synt_1_2; pfam13603
195102002181	nucleotidyl transferase superfamily; Region: nt_trans; cl00015
195102002182	active site
195102002183	KMSKS motif; other site
195102002184	Anticodon-binding domain of bacterial and eukaryotic mitochondrial leucyl tRNA synthetases; Region: Anticodon_Ia_Leu_BEm; cd07958
195102002185	tRNA binding surface [nucleotide binding]; other site
195102002186	Members of the Nudix hydrolase superfamily catalyze the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+, for their activity. They also contain a...; Region: Nudix_Hydrolase_1; cd03674
195102002187	nudix motif; other site
195102002188	bifunctional biotin--[acetyl-CoA-carboxylase] synthetase/biotin operon repressor; Provisional; Region: PRK11886
195102002189	Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090
195102002190	dimerization interface [polypeptide binding]; other site
195102002191	putative DNA binding site [nucleotide binding]; other site
195102002192	putative Zn2+ binding site [ion binding]; other site
195102002193	Biotin/lipoate A/B protein ligase family; Region: BPL_LplA_LipB; pfam03099
195102002194	Biotin protein ligase C terminal domain; Region: BPL_C; pfam02237
195102002195	Nuclease-related domain; Region: NERD; pfam08378
195102002196	HRDC domain; Region: HRDC; pfam00570
195102002197	Domain of unknown function (DUF4184); Region: DUF4184; pfam13803
195102002198	Trimeric dUTP diphosphatases; Region: trimeric_dUTPase; cd07557
195102002199	trimer interface [polypeptide binding]; other site
195102002200	active site
195102002201	Trimeric dUTP diphosphatases; Region: trimeric_dUTPase; cl00493
195102002202	thiamine biosynthesis protein ThiC; Provisional; Region: PRK13352
195102002203	thiamine biosynthesis protein ThiC; Region: thiC; TIGR00190
195102002204	phosphoribosylformylglycinamidine synthase, clade II; Region: FGAM-synthase; TIGR01857
195102002205	AIR (aminoimidazole ribonucleotide) synthase related protein. This family includes Hydrogen expression/formation protein HypE, AIR synthases, FGAM (formylglycinamidine ribonucleotide) synthase and Selenophosphate synthetase (SelD). The N-terminal domain...; Region: PurM-like; cl10019
195102002206	PurL subunit of the formylglycinamide ribonucleotide amidotransferase (FGAR-AT), first repeat. FGAR-AT catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to formylglycinamidine ribonucleotide (FGAM), ADP; Region: PurL_repeat1; cd02203
195102002207	dimerization interface [polypeptide binding]; other site
195102002208	ATP binding site [chemical binding]; other site
195102002209	PurL subunit of the formylglycinamide ribonucleotide amidotransferase (FGAR-AT), second repeat. FGAR-AT catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to formylglycinamidine ribonucleotide (FGAM), ADP; Region: PurL_repeat2; cd02204
195102002210	dimerization interface [polypeptide binding]; other site
195102002211	ATP binding site [chemical binding]; other site
195102002212	Type 1 glutamine amidotransferase (GATase1)-like domain found in Formylglycinamide ribonucleotide amidotransferase; Region: GATase1_FGAR_AT; cd01740
195102002213	putative active site [active]
195102002214	catalytic triad [active]
195102002215	AIR carboxylase; Region: AIRC; pfam00731
195102002216	phosphoribosylaminoimidazole-succinocarboxamide synthase; Reviewed; Region: PRK09362
195102002217	bacterial and archaeal 5-aminoimidazole-4-(N-succinylcarboxamide) ribonucleotide (SAICAR) synthase; Region: SAICAR_synt_PurC; cd01415
195102002218	ATP binding site [chemical binding]; other site
195102002219	active site
195102002220	substrate binding site [chemical binding]; other site
195102002221	amidophosphoribosyltransferase; Provisional; Region: PRK05793
195102002222	Glutamine amidotransferases class-II (GN-AT)_GPAT- type. This domain is found at the N-terminus of  glutamine phosphoribosylpyrophosphate (Prpp) amidotransferase (GPATase) . The glutaminase domain catalyzes amide nitrogen transfer from glutamine to the...; Region: GPATase_N; cd00715
195102002223	active site
195102002224	tetramer interface [polypeptide binding]; other site
195102002225	Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223
195102002226	active site
195102002227	phosphoribosylaminoimidazole synthetase; Provisional; Region: PRK05385
195102002228	PurM (Aminoimidazole Ribonucleotide [AIR] synthetase), one of eleven enzymes required for purine biosynthesis, catalyzes the conversion of formylglycinamide ribonucleotide (FGAM) and ATP to AIR, ADP, and Pi, the fifth step in de novo purine biosynthesis; Region: PurM; cd02196
195102002229	dimerization interface [polypeptide binding]; other site
195102002230	putative ATP binding site [chemical binding]; other site
195102002231	phosphoribosylglycinamide formyltransferase; Reviewed; Region: purN; PRK05647
195102002232	Phosphoribosylglycinamide formyltransferase (GAR transformylase, GART); Region: FMT_core_GART; cd08645
195102002233	active site
195102002234	substrate binding site [chemical binding]; other site
195102002235	cosubstrate binding site; other site
195102002236	catalytic site [active]
195102002237	bifunctional phosphoribosylaminoimidazolecarboxamide formyltransferase/IMP cyclohydrolase; Provisional; Region: purH; PRK00881
195102002238	Inosine monophosphate cyclohydrolase domain. This is the N-terminal domain in the purine biosynthesis pathway protein ATIC (purH). The bifunctional ATIC protein contains a C-terminal  ATIC formylase domain that formylates...; Region: IMPCH; cd01421
195102002239	purine monophosphate binding site [chemical binding]; other site
195102002240	dimer interface [polypeptide binding]; other site
195102002241	putative catalytic residues [active]
195102002242	AICARFT/IMPCHase bienzyme; Region: AICARFT_IMPCHas; smart00798
195102002243	AICARFT/IMPCHase bienzyme; Region: AICARFT_IMPCHas; cl03362
195102002244	phosphoribosylamine--glycine ligase; Provisional; Region: PRK00885
195102002245	Phosphoribosylglycinamide synthetase, ATP-grasp (A) domain; Region: GARS_A; pfam01071
195102002246	Phosphoribosylglycinamide synthetase, C domain; Region: GARS_C; pfam02843
195102002247	hypothetical protein; Provisional; Region: PRK11770
195102002248	Domain of unknown function (DUF307); Region: DUF307; pfam03733
195102002249	Domain of unknown function (DUF307); Region: DUF307; pfam03733
195102002250	Rubredoxin, Small Modular nonheme iron binding domain containing a [Fe(SCys)4] center, present in rubrerythrin and nigerythrin and detected either N- or C-terminal to such proteins as flavin reductase, NAD(P)H-nitrite reductase, and...; Region: rubredoxin_SM; cd00729
195102002251	Rubredoxin; Region: Rubredoxin; pfam00301
195102002252	iron binding site [ion binding]; other site
195102002253	rubrerythrin-like, diiron-binding domain; Region: Rubrerythrin_like; cd01046
195102002254	Rubrerythrin [Energy production and conversion]; Region: COG1592
195102002255	diiron binding motif [ion binding]; other site
195102002256	argininosuccinate lyase; Provisional; Region: PRK00855
195102002257	Argininosuccinate lyase (argininosuccinase, ASAL); Region: Argininosuccinate_lyase; cd01359
195102002258	active sites [active]
195102002259	tetramer interface [polypeptide binding]; other site
195102002260	argininosuccinate synthase; Provisional; Region: PRK13820
195102002261	Argininosuccinate synthase. The Argininosuccinate synthase is a urea cycle enzyme that catalyzes the penultimate step in arginine biosynthesis: the ATP-dependent ligation of citrulline to aspartate to form argininosuccinate, AMP and pyrophosphate .  In...; Region: Argininosuccinate_Synthase; cd01999
195102002262	ANP binding site [chemical binding]; other site
195102002263	Substrate Binding Site II [chemical binding]; other site
195102002264	Substrate Binding Site I [chemical binding]; other site
195102002265	Transaldolase-like fructose-6-phosphate aldolases (FSA) found in bacteria and archaea; Region: Transaldolase_FSA; cd00956
195102002266	active site
195102002267	intersubunit interactions; other site
195102002268	catalytic residue [active]
195102002269	Bacterial Ig-like domain (group 4); Region: Big_4; pfam07532
195102002270	Concanavalin A-like lectin/glucanases superfamily; Region: Laminin_G_3; pfam13385
195102002271	Endo-alpha-N-acetylgalactosaminidase; Region: Glyco_hydro_101; pfam12905
195102002272	Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all...; Region: FN3; cd00063
195102002273	Interdomain contacts; other site
195102002274	Cytokine receptor motif; other site
195102002275	3-deoxy-7-phosphoheptulonate synthase; Reviewed; Region: PRK08673
195102002276	phospho-2-dehydro-3-deoxyheptonate aldolase; Region: DAHP_synth_Bsub; TIGR01361
195102002277	Dehydroquinate synthase (DHQS) catalyzes the conversion of DAHP to DHQ in shikimate pathway for aromatic compounds synthesis; Region: DHQS; cd08195
195102002278	active site
195102002279	dimer interface [polypeptide binding]; other site
195102002280	metal binding site [ion binding]; metal-binding site
195102002281	3-phosphoshikimate 1-carboxyvinyltransferase; Provisional; Region: PRK02427
195102002282	EPSP synthase domain. 3-phosphoshikimate 1-carboxyvinyltransferase (5-enolpyruvylshikimate-3-phosphate synthase) (EC 2.5.1.19) catalyses the reaction between shikimate-3-phosphate (S3P) and phosphoenolpyruvate (PEP) to form...; Region: EPSP_synthase; cd01556
195102002283	hinge; other site
195102002284	active site
195102002285	Chorismate synthase [Amino acid transport and metabolism]; Region: AroC; COG0082
195102002286	Chorismase synthase, the enzyme catalyzing the final step of the shikimate pathway; Region: Chorismate_synthase; cd07304
195102002287	Tetramer interface [polypeptide binding]; other site
195102002288	active site
195102002289	FMN-binding site [chemical binding]; other site
195102002290	Chorismate mutase type II; Region: CM_2; smart00830
195102002291	Shikimate 5-dehydrogenase [Amino acid transport and metabolism]; Region: AroE; COG0169
195102002292	Shikimate dehydrogenase substrate binding domain; Region: Shikimate_dh_N; pfam08501
195102002293	NAD(P) binding domain of Shikimate dehydrogenase; Region: NAD_bind_Shikimate_DH; cd01065
195102002294	shikimate binding site; other site
195102002295	NAD(P) binding site [chemical binding]; other site
195102002296	Shikimate kinase [Amino acid transport and metabolism]; Region: AroK; COG0703
195102002297	Shikimate kinase (SK) is the fifth enzyme in the shikimate pathway, a seven-step biosynthetic pathway which converts erythrose-4-phosphate to chorismic acid, found in bacteria, fungi and plants. Chorismic acid is a important intermediate in the synthesis...; Region: SK; cd00464
195102002298	ADP binding site [chemical binding]; other site
195102002299	magnesium binding site [ion binding]; other site
195102002300	putative shikimate binding site; other site
195102002301	Dehydroquinase class II; Region: DHquinase_II; pfam01220
195102002302	Dehydroquinase (DHQase), type II. Dehydroquinase (or 3-dehydroquinate dehydratase) catalyzes the reversible dehydration of 3-dehydroquinate to form 3-dehydroshikimate. This reaction is part of two metabolic pathways: the biosynthetic shikimate pathway...; Region: DHQase_II; cd00466
195102002303	trimer interface [polypeptide binding]; other site
195102002304	active site
195102002305	dimer interface [polypeptide binding]; other site
195102002306	Predicted transcriptional regulators [Transcription]; Region: COG1695
195102002307	Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090
195102002308	putative DNA binding site [nucleotide binding]; other site
195102002309	putative Zn2+ binding site [ion binding]; other site
195102002310	ABC-type uncharacterized transport system, ATPase component [General function prediction only]; Region: COG4152
195102002311	ATP-binding cassette domain of an uncharacterized transporter; Region: ABC_putative_ATPase; cd03269
195102002312	Walker A/P-loop; other site
195102002313	ATP binding site [chemical binding]; other site
195102002314	Q-loop/lid; other site
195102002315	ABC transporter signature motif; other site
195102002316	Walker B; other site
195102002317	D-loop; other site
195102002318	H-loop/switch region; other site
195102002319	Domain of unknown function (DUF4162); Region: DUF4162; pfam13732
195102002320	ABC-type Na+ efflux pump, permease component [Energy production and conversion / Inorganic ion transport and metabolism]; Region: NatB; COG1668
195102002321	ABC-2 family transporter protein; Region: ABC2_membrane_2; cl17866
195102002322	Linear amide C-N hydrolases, choloylglycine hydrolase family; Region: CBAH; pfam02275
195102002323	Penicillin V acylase (PVA), also known as conjugated bile salt acid hydrolase (CBAH), catalyzes the hydrolysis of penicillin V to yield 6-amino penicillanic acid (6-APA), an important key intermediate of semisynthetic penicillins.  PVA has an N-terminal...; Region: Ntn_PVA; cd00542
195102002324	active site
195102002325	Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cl17220
195102002326	helix_turn_helix ASNC type; Region: HTH_ASNC; smart00344
195102002327	AsnC family; Region: AsnC_trans_reg; pfam01037
195102002328	hypothetical protein; Validated; Region: PRK07682
195102002329	Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609
195102002330	pyridoxal 5'-phosphate binding site [chemical binding]; other site
195102002331	homodimer interface [polypeptide binding]; other site
195102002332	catalytic residue [active]
195102002333	Zinc dependent phospholipase C (alpha toxin); Region: Zn_dep_PLPC; smart00770
195102002334	Zn binding site [ion binding]; other site
195102002335	diacylglycerol glucosyltransferase; Provisional; Region: PRK13608
195102002336	Monogalactosyldiacylglycerol (MGDG) synthase; Region: MGDG_synth; pfam06925
195102002337	Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013
195102002338	Acetyltransferases [General function prediction only]; Region: RimI; COG0456
195102002339	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301
195102002340	Coenzyme A binding pocket [chemical binding]; other site
195102002341	RNA polymerase sigma-70 factor, TIGR02954 family; Region: Sig70_famx3
195102002342	Sigma-70 region 2; Region: Sigma70_r2; pfam04542
195102002343	Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171
195102002344	DNA binding residues [nucleotide binding]
195102002345	Domain of unknown function (DUF4179); Region: DUF4179; pfam13786
195102002346	Predicted metal-dependent hydrolases related to alanyl-tRNA synthetase HxxxH domain [General function prediction only]; Region: COG2872
195102002347	Threonyl and Alanyl tRNA synthetase second additional domain; Region: tRNA_SAD; smart00863
195102002348	Glycosyltransferases involved in cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WcaA; COG0463
195102002349	Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cd00761
195102002350	active site
195102002351	Predicted permease, member of the PurR regulon [General function prediction only]; Region: yhhT; COG0628
195102002352	Domain of unknown function DUF20; Region: UPF0118; pfam01594
195102002353	zinc transporter ZupT; Provisional; Region: PRK04201
195102002354	ZIP Zinc transporter; Region: Zip; pfam02535
195102002355	Transcriptional regulators of sugar metabolism [Transcription / Carbohydrate transport and metabolism]; Region: GlpR; COG1349
195102002356	DeoR-like helix-turn-helix domain; Region: HTH_DeoR; cl17531
195102002357	DeoR C terminal sensor domain; Region: DeoRC; pfam00455
195102002358	haloacid dehalogenase-like hydrolase; Region: Hydrolase_3; pfam08282
195102002359	Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427
195102002360	active site
195102002361	motif I; other site
195102002362	motif II; other site
195102002363	haloacid dehalogenase-like hydrolase; Region: HAD; cl17202
195102002364	spore photoproduct lyase; Region: photo_TT_lyase; TIGR04070
195102002365	DNA repair photolyase [DNA replication, recombination, and repair]; Region: SplB; COG1533
195102002366	Sialidase, N-terminal domain; Region: Sialidase; pfam02973
195102002367	Sialidases or neuraminidases function to bind and hydrolyze terminal sialic acid residues from various glycoconjugates as well as playing roles in pathogenesis, bacterial nutrition and cellular interactions. They have a six-bladed, beta-propeller fold...; Region: Sialidase; cd00260
195102002368	catalytic site [active]
195102002369	BNR repeat-like domain; Region: BNR_2; pfam13088
195102002370	Sialidases or neuraminidases function to bind and hydrolyze terminal sialic acid residues from various glycoconjugates as well as playing roles in pathogenesis, bacterial nutrition and cellular interactions. They have a six-bladed, beta-propeller fold...; Region: Sialidase; cd00260
195102002371	Asp-box motif; other site
195102002372	Asp-box motif; other site
195102002373	catalytic site [active]
195102002374	cyclically-permuted mutarotase family protein; Region: mutarot_permut; TIGR03548
195102002375	Galactose oxidase, central domain; Region: Kelch_3; cl02701
195102002376	Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396
195102002377	Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093
195102002378	non-specific DNA binding site [nucleotide binding]; other site
195102002379	salt bridge; other site
195102002380	sequence-specific DNA binding site [nucleotide binding]; other site
195102002381	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
195102002382	NAD(P) binding site [chemical binding]; other site
195102002383	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
195102002384	active site
195102002385	Acetyltransferases [General function prediction only]; Region: RimI; COG0456
195102002386	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301
195102002387	Coenzyme A binding pocket [chemical binding]; other site
195102002388	MYM-type Zinc finger with FCS sequence motif; Region: zf-FCS; pfam06467
195102002389	Adenine nucleotide alpha hydrolases superfamily including N type ATP PPases, ATP sulphurylases Universal Stress Response protein and electron transfer flavoprotein (ETF). The domain forms a apha/beta/apha fold which  binds to Adenosine nucleotide; Region: AANH_like; cl00292
195102002390	Transcriptional regulator [Transcription]; Region: LysR; COG0583
195102002391	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
195102002392	The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398
195102002393	dimerization interface [polypeptide binding]; other site
195102002394	CoA-disulfide reductase; Region: CoA_CoA_reduc; TIGR03385
195102002395	NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500
195102002396	Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070
195102002397	Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain; Region: Pyr_redox_dim; pfam02852
195102002398	Rhodanese Homology Domain (RHOD); an alpha beta fold domain found duplicated in the rhodanese protein. The cysteine containing enzymatically active version of the domain is also found in the Cdc25 class of protein phosphatases and a variety of proteins...; Region: RHOD; cd00158
195102002399	active site residue [active]
195102002400	Sulphur transport; Region: Sulf_transp; pfam04143
195102002401	Amino acid permease; Region: AA_permease_2; pfam13520
195102002402	Fibronectin-binding protein (FBP); Region: FBP; pfam07299
195102002403	TRX family; composed of two groups: Group I, which includes proteins that exclusively encode a TRX domain; and Group II, which are composed of fusion proteins of TRX and additional domains. Group I TRX is a small ancient protein that alter the redox...; Region: TRX_family; cd02947
195102002404	catalytic residues [active]
195102002405	Predicted transcriptional regulators [Transcription]; Region: COG1733
195102002406	HxlR-like helix-turn-helix; Region: HxlR; pfam01638
195102002407	Cytochrome c biogenesis protein [Posttranslational modification, protein turnover, chaperones]; Region: CcdA; COG0785
195102002408	Cytochrome C biogenesis protein transmembrane region; Region: DsbD; pfam02683
195102002409	TlpA-like family; composed of  TlpA, ResA, DsbE and similar proteins. TlpA, ResA and DsbE are bacterial protein disulfide reductases with important roles in cytochrome maturation. They are membrane-anchored proteins with a soluble TRX domain containing a...; Region: TlpA_like_family; cd02966
195102002410	Thioredoxin-like; Region: Thioredoxin_8; pfam13905
195102002411	catalytic residues [active]
195102002412	SGNH_hydrolase, or GDSL_hydrolase, is a diverse family of lipases and esterases. The tertiary fold of the enzyme is substantially different from that of the alpha/beta hydrolase family and unique among all known hydrolases; its active site closely...; Region: SGNH_hydrolase; cl01053
195102002413	Esterases and lipases (includes fungal lipases, cholinesterases, etc.)  These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cd00312
195102002414	alpha/beta hydrolase fold; Region: Abhydrolase_3; pfam07859
195102002415	Prolyl oligopeptidase family; Region: Peptidase_S9; pfam00326
195102002416	Carbon starvation protein CstA; Region: CstA; pfam02554
195102002417	Carbon starvation protein, predicted membrane protein [Signal transduction mechanisms]; Region: CstA; COG1966
195102002418	Carbon starvation protein, predicted membrane protein [Signal transduction mechanisms]; Region: CstA; COG1966
195102002419	Carbon starvation protein CstA; Region: CstA; pfam02554
195102002420	C-terminal domain on CstA (DUF4161); Region: DUF4161; pfam13722
195102002421	Transcriptional regulator [Transcription]; Region: AcrR; COG1309
195102002422	Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440
195102002423	Transcriptional regulator C-terminal region; Region: TetR_C_8; pfam14278
195102002424	ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136
195102002425	ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255
195102002426	Walker A/P-loop; other site
195102002427	ATP binding site [chemical binding]; other site
195102002428	Q-loop/lid; other site
195102002429	ABC transporter signature motif; other site
195102002430	Walker B; other site
195102002431	D-loop; other site
195102002432	H-loop/switch region; other site
195102002433	ABC-type antimicrobial peptide transport system, permease component [Defense mechanisms]; Region: SalY; COG0577
195102002434	FtsX-like permease family; Region: FtsX; pfam02687
195102002435	MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704
195102002436	ABC-type antimicrobial peptide transport system, permease component [Defense mechanisms]; Region: SalY; COG0577
195102002437	FtsX-like permease family; Region: FtsX; pfam02687
195102002438	Acetyltransferase (GNAT) domain; Region: Acetyltransf_10; pfam13673
195102002439	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301
195102002440	Coenzyme A binding pocket [chemical binding]; other site
195102002441	Enterocin A Immunity; Region: EntA_Immun; pfam08951
195102002442	cardiolipin synthase; Region: bac_cardiolipin; TIGR04265
195102002443	Phospholipase_D-nuclease N-terminal; Region: PLDc_N; pfam13396
195102002444	Catalytic domain, repeat 1, of bacterial cardiolipin synthase and similar proteins; Region: PLDc_CLS_1; cd09110
195102002445	putative active site [active]
195102002446	catalytic site [active]
195102002447	catalytic domain repeat 2 of bacterial cardiolipin synthase and similar proteins; Region: PLDc_CLS_2; cd09112
195102002448	putative active site [active]
195102002449	catalytic site [active]
195102002450	NADH pyrophosphatase, a member of the Nudix hydrolase superfamily, catalyzes the cleavage of NADH into reduced nicotinamide mononucleotide (NMNH) and AMP. Like other members of the Nudix family, it requires a divalent cation, such as Mg2+ or Mn2+, for...; Region: NADH_pyrophosphatase; cd03429
195102002451	putative NADH binding site [chemical binding]; other site
195102002452	putative active site [active]
195102002453	nudix motif; other site
195102002454	putative metal binding site [ion binding]; other site
195102002455	cytosine deaminase; Provisional; Region: PRK09230
195102002456	Bacterial cytosine deaminase and related metal-dependent hydrolases. Cytosine deaminases (CDs) catalyze the deamination of cytosine, producing uracil and ammonia. They play an important role in pyrimidine salvage. CDs are present in prokaryotes and fungi; Region: Bact_CD; cd01293
195102002457	active site
195102002458	Creatinine amidohydrolase; Region: Creatininase; pfam02633
195102002459	EamA-like transporter family; Region: EamA; pfam00892
195102002460	EamA-like transporter family; Region: EamA; pfam00892
195102002461	Purine catabolism regulatory protein-like family; Region: PucR; pfam07905
195102002462	PucR C-terminal helix-turn-helix domain; Region: HTH_30; pfam13556
195102002463	Polypeptide or peptide deformylase; a family of metalloenzymes that catalyzes the removal of the N-terminal formyl group in a growing polypeptide chain following translation initiation during protein synthesis in prokaryotes. These enzymes utilize Fe(II)...; Region: Pep_deformylase; cd00487
195102002464	active site
195102002465	catalytic residues [active]
195102002466	metal binding site [ion binding]; metal-binding site
195102002467	Na+/H+-dicarboxylate symporters [Energy production and conversion]; Region: GltP; COG1301
195102002468	Sodium:dicarboxylate symporter family; Region: SDF; cl00573
195102002469	dUMP phosphatase; Provisional; Region: PRK09449
195102002470	Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427
195102002471	motif II; other site
195102002472	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301
195102002473	Coenzyme A binding pocket [chemical binding]; other site
195102002474	Helix-Turn-Helix DNA binding domain of the BltR transcription regulator; Region: HTH_BltR; cd04782
195102002475	MerR HTH family regulatory protein; Region: MerR_1; pfam13411
195102002476	DNA binding residues [nucleotide binding]
195102002477	dimer interface [polypeptide binding]; other site
195102002478	Domain of unknown function (DUF4317); Region: DUF4317; pfam14199
195102002479	Domain of unknown function (DUF4317); Region: DUF4317; pfam14199
195102002480	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG0675
195102002481	Helix-turn-helix domain; Region: HTH_OrfB_IS605; pfam12323
195102002482	Probable transposase; Region: OrfB_IS605; pfam01385
195102002483	transposase, IS605 OrfB family, central region; Region: tspaseT_teng_C; TIGR01766
195102002484	Probable zinc-binding domain; Region: zf-trcl; pfam13451
195102002485	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
195102002486	MFS/sugar transport protein; Region: MFS_2; pfam13347
195102002487	AraC-like ligand binding domain; Region: AraC_binding; pfam02311
195102002488	Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165
195102002489	helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342
195102002490	Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165
195102002491	cryptic beta-D-galactosidase subunit alpha; Reviewed; Region: ebgA; PRK10340
195102002492	Glycosyl hydrolases family 2, sugar binding domain; Region: Glyco_hydro_2_N; pfam02837
195102002493	Glycosyl hydrolases family 2; Region: Glyco_hydro_2; pfam00703
195102002494	Glycosyl hydrolases family 2, TIM barrel domain; Region: Glyco_hydro_2_C; pfam02836
195102002495	Beta galactosidase small chain; Region: Bgal_small_N; smart01038
195102002496	H+/gluconate symporter and related permeases [Carbohydrate transport and metabolism / Amino acid transport and metabolism]; Region: GntT; COG2610
195102002497	fructuronate transporter; Provisional; Region: PRK10034; cl15264
195102002498	Family of unknown function (DUF438); Region: DUF438; pfam04282
195102002499	Hemerythrin-like domain; Region: Hr-like; cd12108
195102002500	Fe binding site [ion binding]; other site
195102002501	Domain of Unknown function (DUF542); Region: ScdA_N; pfam04405
195102002502	iron-sulfur cluster repair di-iron protein; Region: FeS_repair_RIC; TIGR03652
195102002503	Hemerythrin HHE cation binding domain; Region: Hemerythrin; pfam01814
195102002504	cAMP-binding proteins - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases [Signal transduction mechanisms]; Region: Crp; COG0664
195102002505	effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038
195102002506	ligand binding site [chemical binding]; other site
195102002507	flexible hinge region; other site
195102002508	helix_turn_helix, cAMP Regulatory protein C-terminus; DNA binding domain of prokaryotic regulatory proteins belonging to the catabolite activator protein family; Region: HTH_CRP; cd00092
195102002509	putative switch regulator; other site
195102002510	non-specific DNA interactions [nucleotide binding]; other site
195102002511	DNA binding site [nucleotide binding]
195102002512	sequence specific DNA binding site [nucleotide binding]; other site
195102002513	putative cAMP binding site [chemical binding]; other site
195102002514	Rubredoxin [Energy production and conversion]; Region: COG1773
195102002515	Rubredoxin; nonheme iron binding domains containing a [Fe(SCys)4] center. Rubredoxins are small nonheme iron proteins. The iron atom is coordinated by four cysteine residues (Fe(S-Cys)4), but iron can also be replaced by cobalt, nickel or zinc. They are...; Region: rubredoxin; cd00730
195102002516	iron binding site [ion binding]; other site
195102002517	FAD_NAD(P)H binding domain of flavohemoglobin. Flavohemoglobins have a globin domain containing a B-type heme fused with a ferredoxin reductase-like FAD/NAD-binding domain. Flavohemoglobins detoxify nitric oxide (NO) via an NO dioxygenase reaction. The...; Region: flavohem_like_fad_nad_binding; cd06184
195102002518	FAD binding pocket [chemical binding]; other site
195102002519	FAD binding motif [chemical binding]; other site
195102002520	phosphate binding motif [ion binding]; other site
195102002521	beta-alpha-beta structure motif; other site
195102002522	NAD binding pocket [chemical binding]; other site
195102002523	cAMP-binding proteins - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases [Signal transduction mechanisms]; Region: Crp; COG0664
195102002524	effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038
195102002525	ligand binding site [chemical binding]; other site
195102002526	flexible hinge region; other site
195102002527	helix_turn_helix, cAMP Regulatory protein C-terminus; DNA binding domain of prokaryotic regulatory proteins belonging to the catabolite activator protein family; Region: HTH_CRP; cd00092
195102002528	putative switch regulator; other site
195102002529	non-specific DNA interactions [nucleotide binding]; other site
195102002530	DNA binding site [nucleotide binding]
195102002531	sequence specific DNA binding site [nucleotide binding]; other site
195102002532	putative cAMP binding site [chemical binding]; other site
195102002533	Rubredoxin; Region: Rubredoxin; pfam00301
195102002534	Rubredoxin; nonheme iron binding domains containing a [Fe(SCys)4] center. Rubredoxins are small nonheme iron proteins. The iron atom is coordinated by four cysteine residues (Fe(S-Cys)4), but iron can also be replaced by cobalt, nickel or zinc. They are...; Region: rubredoxin; cd00730
195102002535	iron binding site [ion binding]; other site
195102002536	Uncharacterized flavoproteins [Energy production and conversion]; Region: FpaA; COG0426
195102002537	Metallo-beta-lactamase superfamily; Region: Lactamase_B; smart00849
195102002538	Flavodoxin-like fold; Region: Flavodoxin_2; cl00438
195102002539	peroxiredoxin; Region: AhpC; TIGR03137
195102002540	Peroxiredoxin (PRX) family, Typical 2-Cys PRX subfamily; PRXs are thiol-specific antioxidant (TSA) proteins, which confer a protective role in cells through its peroxidase activity by reducing hydrogen peroxide, peroxynitrite, and organic hydroperoxides; Region: PRX_Typ2cys; cd03015
195102002541	dimer interface [polypeptide binding]; other site
195102002542	decamer (pentamer of dimers) interface [polypeptide binding]; other site
195102002543	catalytic triad [active]
195102002544	peroxidatic and resolving cysteines [active]
195102002545	putative alkyl hydroperoxide reductase F subunit; Region: AhpF_homolog; TIGR03143
195102002546	Anaerobic glycerol-3-phosphate dehydrogenase [Amino acid transport and metabolism]; Region: GlpB; cl17730
195102002547	Alkyl hydroperoxide reductase F subunit (AhpF) N-terminal domain (NTD) family, N-terminal TRX-fold subdomain; AhpF is a homodimeric flavoenzyme which catalyzes the NADH-dependent reduction of the peroxiredoxin AhpC, which in turn catalyzes the reduction...; Region: AhpF_NTD_N; cd02974
195102002548	catalytic residue [active]
195102002549	TRX-GRX-like family, Alkyl hydroperoxide reductase F subunit (AhpF) N-terminal domain (NTD) subfamily, C-terminal TRX-fold subdomain; AhpF is a homodimeric flavoenzyme which catalyzes the NADH-dependent reduction of the peroxiredoxin AhpC, which then...; Region: AhpF_NTD_C; cd03026
195102002550	catalytic residues [active]
195102002551	ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221
195102002552	ATPase components of ABC transporters with duplicated ATPase domains [General function prediction only]; Region: Uup; COG0488
195102002553	ABC transporter; Region: ABC_tran_2; pfam12848
195102002554	ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221
195102002555	ABC transporter; Region: ABC_tran; pfam00005
195102002556	Predicted membrane protein, putative toxin regulator [General function prediction only]; Region: PfoR; COG3641
195102002557	Phosphotransferase system, EIIC; Region: PTS_EIIC_2; pfam13303
195102002558	2-dehydropantoate 2-reductase; Reviewed; Region: PRK06522
195102002559	Ketopantoate reductase PanE/ApbA; Region: ApbA; pfam02558
195102002560	Ketopantoate reductase PanE/ApbA C terminal; Region: ApbA_C; pfam08546
195102002561	helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347
195102002562	MarR family; Region: MarR_2; pfam12802
195102002563	helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347
195102002564	MarR family; Region: MarR_2; pfam12802
195102002565	MarR family; Region: MarR_2; cl17246
195102002566	Pirin-related protein [General function prediction only]; Region: COG1741
195102002567	Pirin; Region: Pirin; pfam02678
195102002568	Pirin C-terminal cupin domain; Region: Pirin_C; pfam05726
195102002569	Acyl carrier protein phosphodiesterase [Lipid metabolism]; Region: AcpD; COG1182
195102002570	NADPH-dependent FMN reductase; Region: FMN_red; pfam03358
195102002571	Fe3+-siderophore binding domain FhuD.  These proteins have been shown to function as initial receptors in ABC transport of Fe3+-siderophores in many eubacterial species. They belong to the TroA-like superfamily of helical backbone metal receptor proteins...; Region: FhuD; cd01146
195102002572	Periplasmic binding protein; Region: Peripla_BP_2; pfam01497
195102002573	siderophore binding site; other site
195102002574	iron-hydroxamate transporter permease subunit; Provisional; Region: PRK10577
195102002575	Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550
195102002576	ABC-ATPase subunit  interface; other site
195102002577	dimer interface [polypeptide binding]; other site
195102002578	putative PBP binding regions; other site
195102002579	iron-hydroxamate transporter permease subunit; Provisional; Region: PRK10577
195102002580	Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550
195102002581	ABC-ATPase subunit  interface; other site
195102002582	dimer interface [polypeptide binding]; other site
195102002583	putative PBP binding regions; other site
195102002584	ABC-type cobalamin/Fe3+-siderophores transport systems, ATPase components [Inorganic ion transport and metabolism / Coenzyme metabolism]; Region: FepC; COG1120
195102002585	ATP-binding component of iron-siderophores, vitamin B12 and hemin transporters and related proteins; Region: ABC_Iron-Siderophores_B12_Hemin; cd03214
195102002586	Walker A/P-loop; other site
195102002587	ATP binding site [chemical binding]; other site
195102002588	Q-loop/lid; other site
195102002589	ABC transporter signature motif; other site
195102002590	Walker B; other site
195102002591	D-loop; other site
195102002592	H-loop/switch region; other site
195102002593	Members of the Nudix hydrolase superfamily catalyze the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+, for their activity and contain a highly...; Region: Nudix_Hydrolase_27; cd04686
195102002594	nudix motif; other site
195102002595	PAP2_like proteins, a super-family of histidine phosphatases and vanadium haloperoxidases, includes type 2 phosphatidic acid phosphatase or lipid phosphate phosphatase (LPP), Glucose-6-phosphatase, Phosphatidylglycerophosphatase B and bacterial acid...; Region: PAP2_like; cl00474
195102002596	Membrane-associated phospholipid phosphatase [Lipid metabolism]; Region: PgpB; COG0671
195102002597	active site
195102002598	Protein of unknown function DUF45; Region: DUF45; cl00636
195102002599	Protein of unknown function DUF45; Region: DUF45; pfam01863
195102002600	PAS fold; Region: PAS_4; pfam08448
195102002601	c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal    transduction mechanisms]; Region: COG2199
195102002602	Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949
195102002603	metal binding site [ion binding]; metal-binding site
195102002604	active site
195102002605	I-site; other site
195102002606	Polymerase and Histidinol Phosphatase domain of Histidinol phosphate phosphatase of Hisj like; Region: PHP_HisPPase_Hisj_like; cd12110
195102002607	histidinol-phosphatase; Reviewed; Region: PRK08123
195102002608	active site
195102002609	dimer interface [polypeptide binding]; other site
195102002610	N-terminal Early set domain associated with the catalytic domain of cyclomaltodextrinase and pullulan-degrading enzymes; Region: E_set_CDase_PDE_N; cd02857
195102002611	homodimer interface [polypeptide binding]; other site
195102002612	Alpha amylase catalytic domain found in cyclomaltodextrinases and related proteins; Region: AmyAc_CMD; cd11338
195102002613	active site
195102002614	homodimer interface [polypeptide binding]; other site
195102002615	catalytic site [active]
195102002616	L-cysteine desulfidase [Amino acid transport and metabolism]; Region: COG3681
195102002617	YdcF-like. YdcF-like is a large family of mainly bacterial proteins, with a few members found in fungi, plants, and archaea. Escherichia coli YdcF has been shown to bind S-adenosyl-L-methionine (AdoMet), but a biochemical function has not been...; Region: YdcF-like; cd06259
195102002618	Uncharacterized conserved protein [Function unknown]; Region: COG1434
195102002619	putative active site [active]
195102002620	ABC-type Fe3+-hydroxamate transport system, periplasmic component [Inorganic ion transport and metabolism]; Region: FepB; COG0614
195102002621	Periplasmic binding protein FeuA.  These proteins have predicted to function as initial receptors in ABC transport of metal ions in some eubacterial species.  They belong to the TroA superfamily of periplasmic metal binding proteins that share a distinct...; Region: FeuA; cd01138
195102002622	putative ligand binding residues [chemical binding]; other site
195102002623	iron-hydroxamate transporter permease subunit; Provisional; Region: PRK10577
195102002624	Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550
195102002625	ABC-ATPase subunit  interface; other site
195102002626	dimer interface [polypeptide binding]; other site
195102002627	putative PBP binding regions; other site
195102002628	iron-hydroxamate transporter permease subunit; Provisional; Region: PRK10577
195102002629	Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550
195102002630	ABC-ATPase subunit  interface; other site
195102002631	dimer interface [polypeptide binding]; other site
195102002632	putative PBP binding regions; other site
195102002633	ABC-type cobalamin/Fe3+-siderophores transport systems, ATPase components [Inorganic ion transport and metabolism / Coenzyme metabolism]; Region: FepC; COG1120
195102002634	ATP-binding component of iron-siderophores, vitamin B12 and hemin transporters and related proteins; Region: ABC_Iron-Siderophores_B12_Hemin; cd03214
195102002635	Walker A/P-loop; other site
195102002636	ATP binding site [chemical binding]; other site
195102002637	Q-loop/lid; other site
195102002638	ABC transporter signature motif; other site
195102002639	Walker B; other site
195102002640	D-loop; other site
195102002641	H-loop/switch region; other site
195102002642	putative acetyltransferase YhhY; Provisional; Region: PRK10140
195102002643	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301
195102002644	Coenzyme A binding pocket [chemical binding]; other site
195102002645	Domain of unknown function (DUF4177); Region: DUF4177; pfam13783
195102002646	Endo-beta-N-acetylglucosaminidase D [Carbohydrate transport and metabolism]; Region: COG4724
195102002647	Endo-beta-N-acetylglucosaminidase (ENGase) hydrolyzes the N-N'-diacetylchitobiosyl core of N-glycosylproteins.  The beta-1,4-glycosyl bond located between two N-acetylglucosamine residues is hydrolyzed such that N-acetylglucosamine 1 remains with...; Region: GH85_ENGase; cd06547
195102002648	putative active site [active]
195102002649	F5/8 type C domain; Region: F5_F8_type_C; pfam00754
195102002650	sugar binding site [chemical binding]; other site
195102002651	Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all...; Region: FN3; cd00063
195102002652	Interdomain contacts; other site
195102002653	Cytokine receptor motif; other site
195102002654	D-alanine--D-alanine ligase; Reviewed; Region: ddl; PRK01372
195102002655	D-ala D-ala ligase N-terminus; Region: Dala_Dala_lig_N; pfam01820
195102002656	ATP-grasp domain; Region: ATP-grasp_4; cl17255
195102002657	Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427
195102002658	haloacid dehalogenase-like hydrolase; Region: Hydrolase_3; pfam08282
195102002659	active site
195102002660	motif I; other site
195102002661	motif II; other site
195102002662	PTS system mannose-specific transporter subunits IIAB; Provisional; Region: PRK15088
195102002663	PTS_IIA, PTS system, mannose/sorbose specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIA_man; cd00006
195102002664	active pocket/dimerization site; other site
195102002665	active site
195102002666	phosphorylation site [posttranslational modification]
195102002667	PTS_IIB, PTS system, Mannose/sorbose specific IIB subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIB_man; cd00001
195102002668	active site
195102002669	phosphorylation site [posttranslational modification]
195102002670	PTS system mannose-specific transporter subunit IIC; Provisional; Region: PRK15065
195102002671	PTS system mannose/fructose/sorbose family IID component; Region: EIID-AGA; pfam03613
195102002672	Phosphotransferase system, mannose/fructose/N-acetylgalactosamine-specific component IID [Carbohydrate transport and metabolism]; Region: ManZ; COG3716
195102002673	Domain of unknown function (DUF956); Region: DUF956; pfam06115
195102002674	delta-lactam-biosynthetic de-N-acetylase; Region: spore_pdaA; TIGR02884
195102002675	Catalytic NodB homology domain of Streptococcus mutans polysaccharide deacetylase PgdA, Bacillus subtilis YheN, and similar proteins; Region: CE4_SmPgdA_like; cd10944
195102002676	NodB motif; other site
195102002677	active site
195102002678	catalytic site [active]
195102002679	Zn binding site [ion binding]; other site
195102002680	conserved hypothetical integral membrane protein TIGR02206; Region: intg_mem_TP0381
195102002681	Na+-driven multidrug efflux pump [Defense mechanisms]; Region: NorM; COG0534
195102002682	Subfamily of the multidrug and toxic compound extrusion (MATE)-like proteins similar to Streptococcus aureus MepA; Region: MATE_MepA_like; cd13143
195102002683	Beta-galactosidase/beta-glucuronidase [Carbohydrate transport and metabolism]; Region: LacZ; COG3250
195102002684	Glycosyl hydrolases family 2, sugar binding domain; Region: Glyco_hydro_2_N; pfam02837
195102002685	Glycosyl hydrolases family 2; Region: Glyco_hydro_2; pfam00703
195102002686	Glycosyl hydrolases family 2, TIM barrel domain; Region: Glyco_hydro_2_C; pfam02836
195102002687	Uncharacterized protein with SCP/PR1 domains [Function unknown]; Region: COG2340
195102002688	SCP_bacterial: SCP-like extracellular protein domain, as found in bacteria and archaea. The wider family of SCP containing proteins includes plant pathogenesis-related protein 1 (PR-1), CRISPs, mammalian cysteine-rich secretory proteins, and allergen 5...; Region: SCP_bacterial; cd05379
195102002689	ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132
195102002690	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
195102002691	Walker A/P-loop; other site
195102002692	ATP binding site [chemical binding]; other site
195102002693	Q-loop/lid; other site
195102002694	ABC transporter signature motif; other site
195102002695	Walker B; other site
195102002696	D-loop; other site
195102002697	H-loop/switch region; other site
195102002698	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
195102002699	ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136
195102002700	Walker A/P-loop; other site
195102002701	ATP binding site [chemical binding]; other site
195102002702	Q-loop/lid; other site
195102002703	ABC transporter signature motif; other site
195102002704	Walker B; other site
195102002705	D-loop; other site
195102002706	H-loop/switch region; other site
195102002707	Uncharacterized conserved protein [Function unknown]; Region: COG3402
195102002708	Bacterial PH domain; Region: DUF304; pfam03703
195102002709	Predicted membrane protein [Function unknown]; Region: COG3428
195102002710	Bacterial PH domain; Region: DUF304; pfam03703
195102002711	Bacterial PH domain; Region: DUF304; pfam03703
195102002712	Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090
195102002713	dimerization interface [polypeptide binding]; other site
195102002714	putative DNA binding site [nucleotide binding]; other site
195102002715	putative Zn2+ binding site [ion binding]; other site
195102002716	Protein-tyrosine-phosphatase [Signal transduction mechanisms]; Region: Wzb; COG0394
195102002717	Low molecular weight phosphatase family; Region: LMWPc; cd00115
195102002718	active site
195102002719	Na+-driven multidrug efflux pump [Defense mechanisms]; Region: NorM; COG0534
195102002720	Uncharacterized subfamily of the multidrug and toxic compound extrusion (MATE) proteins; Region: MATE_like_1; cd13140
195102002721	Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745
195102002722	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
195102002723	active site
195102002724	phosphorylation site [posttranslational modification]
195102002725	intermolecular recognition site; other site
195102002726	dimerization interface [polypeptide binding]; other site
195102002727	Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383
195102002728	DNA binding site [nucleotide binding]
195102002729	Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642
195102002730	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
195102002731	ATP binding site [chemical binding]; other site
195102002732	Mg2+ binding site [ion binding]; other site
195102002733	G-X-G motif; other site
195102002734	Fic/DOC family; Region: Fic; pfam02661
195102002735	clostripain; Region: clostrip; TIGR02806
195102002736	ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136
195102002737	ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255
195102002738	Walker A/P-loop; other site
195102002739	ATP binding site [chemical binding]; other site
195102002740	Q-loop/lid; other site
195102002741	ABC transporter signature motif; other site
195102002742	Walker B; other site
195102002743	D-loop; other site
195102002744	H-loop/switch region; other site
195102002745	KIAA1161 is an uncharacterized Homo sapiens protein with a glycosyl hydrolase family 31 (GH31) domain that is homologous to the Escherichia coli YihQ glucosidase. Orthologs of KIA1161 are found in eukaryotes and prokaryotes. In bacteria, YihQ (along with...; Region: GH31_glucosidase_KIAA1161; cd06592
195102002746	Alpha-glucosidases, family 31 of glycosyl hydrolases [Carbohydrate transport and metabolism]; Region: COG1501
195102002747	putative active site [active]
195102002748	putative catalytic site [active]
195102002749	Stress responsive A/B Barrel Domain; Region: Dabb; smart00886
195102002750	Serine-pyruvate aminotransferase/archaeal aspartate aminotransferase [Amino acid transport and metabolism]; Region: COG0075
195102002751	pyridoxal 5'-phosphate binding pocket [chemical binding]; other site
195102002752	catalytic residue [active]
195102002753	Rubrerythrin [Energy production and conversion]; Region: COG1592
195102002754	Rubrerythrin, ferritin-like diiron-binding domain; Region: Rubrerythrin; cd01041
195102002755	binuclear metal center [ion binding]; other site
195102002756	Rubredoxin, Small Modular nonheme iron binding domain containing a [Fe(SCys)4] center, present in rubrerythrin and nigerythrin and detected either N- or C-terminal to such proteins as flavin reductase, NAD(P)H-nitrite reductase, and...; Region: rubredoxin_SM; cd00729
195102002757	iron binding site [ion binding]; other site
195102002758	N-terminal catalytic domain of endoplasmic reticulum(ER)/cytosolic class II alpha-mannosidases; glycoside hydrolase family 38 (GH38); Region: GH38N_AMII_ER_cytosolic; cd10789
195102002759	active site
195102002760	catalytic site [active]
195102002761	Alpha mannosidase, middle domain; Region: Alpha-mann_mid; smart00872
195102002762	Glycosyl hydrolases family 38 C-terminal domain; Region: Glyco_hydro_38C; pfam07748
195102002763	Acetyltransferase (GNAT) domain; Region: Acetyltransf_3; pfam13302
195102002764	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301
195102002765	Coenzyme A binding pocket [chemical binding]; other site
195102002766	Uncharacterized oxidoreductases, Fe-dependent alcohol dehydrogenase family [Energy production and conversion]; Region: COG1979
195102002767	Butanol dehydrogenase catalyzes the conversion of butyraldehyde to butanol with the cofactor NAD(P)H being oxidized in the process; Region: BDH; cd08187
195102002768	dimer interface [polypeptide binding]; other site
195102002769	active site
195102002770	metal binding site [ion binding]; metal-binding site
195102002771	Putative sugar diacid recognition; Region: Diacid_rec; pfam05651
195102002772	Sugar diacid utilization regulator [Transcription / Signal transduction mechanisms]; Region: CdaR; COG3835
195102002773	PucR C-terminal helix-turn-helix domain; Region: HTH_30; pfam13556
195102002774	H+/gluconate symporter and related permeases [Carbohydrate transport and metabolism / Amino acid transport and metabolism]; Region: GntT; COG2610
195102002775	fructuronate transporter; Provisional; Region: PRK10034; cl15264
195102002776	Glycerate kinase [Carbohydrate transport and metabolism]; Region: COG1929
195102002777	ATP-dependent RNA helicase DbpA; Provisional; Region: PRK11776
195102002778	DEAD-box helicases. A diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker  B motif; Region: DEADc; cd00268
195102002779	ATP binding site [chemical binding]; other site
195102002780	Mg++ binding site [ion binding]; other site
195102002781	motif III; other site
195102002782	Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079
195102002783	nucleotide binding region [chemical binding]; other site
195102002784	ATP-binding site [chemical binding]; other site
195102002785	RNA recognition motif in Bacillus subtilis ATP-dependent RNA helicase YxiN and similar proteins; Region: RRM_BsYxiN_like; cd12500
195102002786	RNA binding site [nucleotide binding]; other site
195102002787	Na+-driven multidrug efflux pump [Defense mechanisms]; Region: NorM; COG0534
195102002788	Uncharacterized subfamily of the multidrug and toxic compound extrusion (MATE) proteins; Region: MATE_like_8; cd13134
195102002789	F5/8 type C domain; Region: F5_F8_type_C; pfam00754
195102002790	sugar binding site [chemical binding]; other site
195102002791	Alpha-N-acetylglucosaminidase (NAGLU) N-terminal domain; Region: NAGLU_N; pfam12971
195102002792	Alpha-N-acetylglucosaminidase (NAGLU) tim-barrel domain; Region: NAGLU; pfam05089
195102002793	Alpha-N-acetylglucosaminidase (NAGLU) C-terminal domain; Region: NAGLU_C; pfam12972
195102002794	F5/8 type C domain; Region: F5_F8_type_C; pfam00754
195102002795	sugar binding site [chemical binding]; other site
195102002796	F5/8 type C domain; Region: F5_F8_type_C; pfam00754
195102002797	F5/8 type C domain; Region: F5_F8_type_C; pfam00754
195102002798	F5/8 type C domain; Region: F5_F8_type_C; pfam00754
195102002799	sugar binding site [chemical binding]; other site
195102002800	F5/8 type C domain; Region: F5_F8_type_C; pfam00754
195102002801	sugar binding site [chemical binding]; other site
195102002802	Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all...; Region: FN3; cd00063
195102002803	Interdomain contacts; other site
195102002804	Cytokine receptor motif; other site
195102002805	alanine racemase; Reviewed; Region: alr; PRK00053
195102002806	Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzyme Alanine Racemase; Region: PLPDE_III_AR; cd00430
195102002807	active site
195102002808	pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site
195102002809	dimer interface [polypeptide binding]; other site
195102002810	substrate binding site [chemical binding]; other site
195102002811	catalytic residues [active]
195102002812	Acetyltransferases [General function prediction only]; Region: RimI; COG0456
195102002813	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301
195102002814	Coenzyme A binding pocket [chemical binding]; other site
195102002815	Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642
195102002816	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
195102002817	ATP binding site [chemical binding]; other site
195102002818	Mg2+ binding site [ion binding]; other site
195102002819	G-X-G motif; other site
195102002820	Accessory gene regulator B; Region: AgrB; smart00793
195102002821	Creatinase/Prolidase N-terminal domain; Region: Creatinase_N; pfam01321
195102002822	Xaa-Pro aminopeptidase [Amino acid transport and metabolism]; Region: PepP; COG0006
195102002823	Creatinase/Prolidase N-terminal domain; Region: Creatinase_N; pfam01321
195102002824	X-Prolyl Aminopeptidase 2. E.C. 3.4.11.9. Also known as X-Pro aminopeptidase, proline aminopeptidase, aminopeptidase P, and aminoacylproline aminopeptidase. Catalyses release of any N-terminal amino acid, including proline, that is linked with proline; Region: APP; cd01085
195102002825	active site
195102002826	Leucyl aminopeptidase (aminopeptidase T) [Amino acid transport and metabolism]; Region: AmpS; COG2309
195102002827	Thermophilic metalloprotease (M29); Region: Peptidase_M29; pfam02073
195102002828	putative acetyltransferase; Provisional; Region: PRK03624
195102002829	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301
195102002830	Coenzyme A binding pocket [chemical binding]; other site
195102002831	Uncharacterized conserved protein [Function unknown]; Region: COG1284
195102002832	Uncharacterized BCR, YitT family COG1284; Region: DUF161; pfam02588
195102002833	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG0675
195102002834	Helix-turn-helix domain; Region: HTH_OrfB_IS605; pfam12323
195102002835	Probable transposase; Region: OrfB_IS605; pfam01385
195102002836	transposase, IS605 OrfB family, central region; Region: tspaseT_teng_C; TIGR01766
195102002837	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301
195102002838	Coenzyme A binding pocket [chemical binding]; other site
195102002839	Protein of unknown function (DUF1189); Region: DUF1189; pfam06691
195102002840	Glycosyl hydrolase family 20, domain 2; Region: Glyco_hydro_20b; pfam02838
195102002841	beta-N-acetylglucosaminidase; Region: NAGidase; pfam07555
195102002842	F5/8 type C domain; Region: F5_F8_type_C; pfam00754
195102002843	sugar binding site [chemical binding]; other site
195102002844	F5/8 type C domain; Region: F5_F8_type_C; pfam00754
195102002845	sugar binding site [chemical binding]; other site
195102002846	hypothetical protein; Provisional; Region: PRK00967
195102002847	ABC-type multidrug transport system, ATPase component [Defense mechanisms]; Region: CcmA; COG1131
195102002848	ATP-binding cassette domain of the drug resistance transporter and related proteins, subfamily A; Region: ABC_DR_subfamily_A; cd03230
195102002849	Walker A/P-loop; other site
195102002850	ATP binding site [chemical binding]; other site
195102002851	Q-loop/lid; other site
195102002852	ABC transporter signature motif; other site
195102002853	Walker B; other site
195102002854	D-loop; other site
195102002855	H-loop/switch region; other site
195102002856	Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118
195102002857	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
195102002858	S-adenosylmethionine binding site [chemical binding]; other site
195102002859	Coenzyme A pyrophosphatase (CoAse), a member of the Nudix hydrolase superfamily, functions to catalyze the elimination of oxidized inactive CoA, which can inhibit CoA-utilizing enzymes. The need of CoAses mainly arises under conditions of oxidative...; Region: CoAse; cd03426
195102002860	putative active site [active]
195102002861	putative CoA binding site [chemical binding]; other site
195102002862	nudix motif; other site
195102002863	metal binding site [ion binding]; metal-binding site
195102002864	SNARE associated Golgi protein; Region: SNARE_assoc; cl00429
195102002865	SNARE associated Golgi protein; Region: SNARE_assoc; pfam09335
195102002866	Uncharacterized membrane-associated protein [Function unknown]; Region: DedA; COG0586
195102002867	Alcohol dehydrogenase, class IV [Energy production and conversion]; Region: EutG; COG1454
195102002868	1,3-propanediol dehydrogenase (PPD) catalyzes the reduction of 3-hydroxypropionaldehyde (3-HPA) to 1,3-propanediol in glycerol metabolism; Region: PDD; cd08180
195102002869	putative active site [active]
195102002870	metal binding site [ion binding]; metal-binding site
195102002871	1,2-propanediol utilization protein U (PduU)/ethanolamine utilization protein S (EutS), Bacterial Micro-Compartment (BMC) domain; Region: BMC_PduU-EutS; cd07046
195102002872	putative hexamer interface [polypeptide binding]; other site
195102002873	putative hexagonal pore; other site
195102002874	Rat sarcoma (Ras)-like superfamily of small guanosine triphosphatases (GTPases); Region: Ras_like_GTPase; cd00882
195102002875	G1 box; other site
195102002876	GTP/Mg2+ binding site [chemical binding]; other site
195102002877	G2 box; other site
195102002878	Switch I region; other site
195102002879	G3 box; other site
195102002880	Switch II region; other site
195102002881	G4 box; other site
195102002882	G5 box; other site
195102002883	Response regulator with putative antiterminator output domain [Signal transduction mechanisms]; Region: AmiR; COG3707
195102002884	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
195102002885	active site
195102002886	phosphorylation site [posttranslational modification]
195102002887	intermolecular recognition site; other site
195102002888	dimerization interface [polypeptide binding]; other site
195102002889	ANTAR domain; Region: ANTAR; pfam03861
195102002890	Signal transduction histidine kinase; Region: H_kinase_N; pfam12282
195102002891	Signal transduction histidine kinase [Signal transduction mechanisms]; Region: COG3920
195102002892	Histidine kinase; Region: HisKA_2; pfam07568
195102002893	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cl00075
195102002894	Mg2+ binding site [ion binding]; other site
195102002895	G-X-G motif; other site
195102002896	Ethanolamine utilisation protein EutA; Region: EutA; pfam06277
195102002897	ethanolamine ammonia lyase large subunit; Provisional; Region: PRK15067
195102002898	Ethanolamine ammonia lyase large subunit (EutB); Region: EutB; pfam06751
195102002899	ethanolamine ammonia-lyase small subunit; Provisional; Region: PRK05465
195102002900	ethanolamine utilization protein EutL; Provisional; Region: PRK15405
195102002901	ethanolamine utilization protein S (EutS), Bacterial Micro-Compartment (BMC) domain repeat 1; Region: BMC_EutL_repeat1; cd07049
195102002902	putative hexamer interface [polypeptide binding]; other site
195102002903	putative hexagonal pore; other site
195102002904	ethanolamine utilization protein S (EutS), Bacterial Micro-Compartment (BMC) domain repeat 2; Region: BMC_EutL_repeat2; cd07050
195102002905	putative hexamer interface [polypeptide binding]; other site
195102002906	putative hexagonal pore; other site
195102002907	Carbon dioxide concentrating mechanism/carboxysome shell protein [Secondary metabolites biosynthesis, transport, and catabolism / Energy production and conversion]; Region: CcmK; COG4577
195102002908	Carbon dioxide concentrating mechanism K (CcmK)-like proteins, Bacterial Micro-Compartment (BMC) domain; Region: BMC_CcmK_like; cd07045
195102002909	Hexamer interface [polypeptide binding]; other site
195102002910	Hexagonal pore residue; other site
195102002911	Coenzyme A acylating aldehyde dehydrogenase (ACDH), ALDH family 20-like; Region: ALDH_F20_ACDH; cd07122
195102002912	putative catalytic cysteine [active]
195102002913	Carbon dioxide concentrating mechanism/carboxysome shell protein [Secondary metabolites biosynthesis, transport, and catabolism / Energy production and conversion]; Region: CcmK; COG4577
195102002914	1,2-propanediol utilization protein A (PduA), Bacterial Micro-Compartment (BMC) domain; Region: BMC_PduA; cd07059
195102002915	Hexamer interface [polypeptide binding]; other site
195102002916	Putative hexagonal pore residue; other site
195102002917	Cobalamin adenosyltransferase; Region: Cob_adeno_trans; cl00920
195102002918	propanediol utilization phosphotransacylase; Provisional; Region: PRK15070
195102002919	Propanediol utilisation protein PduL; Region: PduL; pfam06130
195102002920	Propanediol utilisation protein PduL; Region: PduL; pfam06130
195102002921	ethanolamine utilization protein; Region: eut_hyp; TIGR02536
195102002922	Ethanolamine utilisation protein and carboxysome structural protein domain family; Region: EutN_CcmL; cd01614
195102002923	Hexamer/Pentamer interface [polypeptide binding]; other site
195102002924	central pore; other site
195102002925	PduT-like ethanolamine utilization protein; Region: eut_PduT; TIGR02526
195102002926	1,2-propanediol utilization protein T (PduT), Bacterial Micro-Compartment (BMC) domain repeat 1; Region: BMC_PduT_repeat1; cd07053
195102002927	putative hexamer interface [polypeptide binding]; other site
195102002928	putative hexagonal pore; other site
195102002929	1,2-propanediol utilization protein T (PduT), Bacterial Micro-Compartment (BMC) domain repeat 2; Region: BMC_PduT_repeat2; cd07054
195102002930	putative hexamer interface [polypeptide binding]; other site
195102002931	putative hexagonal pore; other site
195102002932	ethanolamine utilization protein EutH; Provisional; Region: PRK15086
195102002933	Ethanolamine utilisation protein EutQ; Region: EutQ; pfam06249
195102002934	ethanolamine utilization protein EutQ; Provisional; Region: PRK15457
195102002935	Glutathione (GSH) peroxidase family; tetrameric selenoenzymes that catalyze the reduction of a variety of hydroperoxides including lipid peroxidases, using GSH as a specific electron donor substrate. GSH peroxidase contains one selenocysteine residue per...; Region: GSH_Peroxidase; cd00340
195102002936	catalytic residues [active]
195102002937	dimer interface [polypeptide binding]; other site
195102002938	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301
195102002939	Coenzyme A binding pocket [chemical binding]; other site
195102002940	Bacterial periplasmic substrate-binding proteins; Region: PBPb; smart00062
195102002941	Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of  substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134
195102002942	substrate binding pocket [chemical binding]; other site
195102002943	membrane-bound complex binding site; other site
195102002944	hinge residues; other site
195102002945	EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2).  The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948
195102002946	Multimeric flavodoxin WrbA [General function prediction only]; Region: WrbA; COG0655
195102002947	NADPH-dependent FMN reductase; Region: FMN_red; pfam03358
195102002948	anaerobic ribonucleoside-triphosphate reductase; Region: NrdD; TIGR02487
195102002949	Class III ribonucleotide reductase; Region: RNR_III; cd01675
195102002950	effector binding site; other site
195102002951	active site
195102002952	Zn binding site [ion binding]; other site
195102002953	glycine loop; other site
195102002954	4Fe-4S single cluster domain; Region: Fer4_12; pfam13353
195102002955	Nitroreductase-like family 3. A subfamily of the nitroreductase family containing uncharacterized proteins that are similar to nitroreductase. Nitroreductase catalyzes the reduction of nitroaromatic compounds such as nitrotoluenes, nitrofurans and...; Region: Nitroreductase_3; cd02139
195102002956	putative FMN binding site [chemical binding]; other site
195102002957	Metal-dependent hydrolases of the beta-lactamase superfamily II [General function prediction only]; Region: COG1237
195102002958	Predicted Zn-dependent hydrolases of the beta-lactamase fold [General function prediction only]; Region: COG2220
195102002959	Major intrinsic protein (MIP) superfamily. Members of the MIP superfamily function as membrane channels that selectively transport water, small neutral molecules, and ions out of and between cells. The channel proteins share a common fold: the N-terminal...; Region: MIP; cd00333
195102002960	amphipathic channel; other site
195102002961	Asn-Pro-Ala signature motifs; other site
195102002962	Predicted sensor domain [Signal transduction mechanisms / Transcription]; Region: PocR; COG4936
195102002963	Sensory domain found in PocR; Region: PocR; pfam10114
195102002964	Histidine kinase; Region: His_kinase; pfam06580
195102002965	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
195102002966	ATP binding site [chemical binding]; other site
195102002967	Mg2+ binding site [ion binding]; other site
195102002968	G-X-G motif; other site
195102002969	Response regulator receiver domain; Region: Response_reg; pfam00072
195102002970	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
195102002971	active site
195102002972	phosphorylation site [posttranslational modification]
195102002973	intermolecular recognition site; other site
195102002974	dimerization interface [polypeptide binding]; other site
195102002975	Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165
195102002976	helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342
195102002977	Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165
195102002978	Propanediol dehydratase, large subunit [Secondary metabolites biosynthesis, transport, and catabolism]; Region: PduC; COG4909
195102002979	Dehydratase large subunit. This family contains the large (alpha) subunit of B12-dependent glycerol dehydratases (GDHs) and B12-dependent diol dehydratases (DDHs). GDH is isofunctional with DDH. These enzymes can each catalyze the conversion of 1; Region: Dehydratase_LU; cd03687
195102002980	alpha-alpha subunit/dimer interface [polypeptide binding]; other site
195102002981	alpha-beta subunit interface [polypeptide binding]; other site
195102002982	alpha-gamma subunit interface [polypeptide binding]; other site
195102002983	active site
195102002984	substrate and K+ binding site; other site
195102002985	K+ binding site [ion binding]; other site
195102002986	cobalamin binding site [chemical binding]; other site
195102002987	propanediol dehydratase medium subunit; Provisional; Region: pduD; PRK15042
195102002988	Dehydratase small subunit; Region: Dehydratase_SU; pfam02287
195102002989	Condensing enzymes; Family of enzymes that catalyze a (decarboxylating or non-decarboxylating) Claisen-like condensation reaction. Members are share strong structural similarity, and are involved in the synthesis and degradation of fatty acids, and the...; Region: cond_enzymes; cl09938
195102002990	Diol dehydratase reactivase ATPase-like domain; Region: DDR; pfam08841
195102002991	Dehydratase medium subunit; Region: Dehydratase_MU; pfam02288
195102002992	Cobalamin adenosyltransferase; Region: Cob_adeno_trans; pfam01923
195102002993	Domain of unknown function (DUF336); Region: DUF336; pfam03928
195102002994	Alcohol dehydrogenase, class IV [Energy production and conversion]; Region: EutG; COG1454
195102002995	Lactadehyde:propanediol oxidoreductase (LPO) catalyzes the interconversion between L-lactaldehyde and L-1,2-propanediol in Escherichia coli and other enterobacteria; Region: LPO; cd08176
195102002996	dimer interface [polypeptide binding]; other site
195102002997	active site
195102002998	metal binding site [ion binding]; metal-binding site
195102002999	inner membrane transporter YjeM; Provisional; Region: PRK15238
195102003000	Predicted membrane protein [Function unknown]; Region: COG2717
195102003001	Acetyltransferases [General function prediction only]; Region: RimI; COG0456
195102003002	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301
195102003003	Coenzyme A binding pocket [chemical binding]; other site
195102003004	Protein of unknown function (DUF1622); Region: DUF1622; pfam07784
195102003005	Protein of unknown function (DUF1622); Region: DUF1622; pfam07784
195102003006	Lysophospholipase [Lipid metabolism]; Region: PldB; COG2267
195102003007	Putative lysophospholipase; Region: Hydrolase_4; pfam12146
195102003008	Pentapeptide repeats (9 copies); Region: Pentapeptide_4; pfam13599
195102003009	Sodium:dicarboxylate symporter family; Region: SDF; pfam00375
195102003010	Na+/H+-dicarboxylate symporters [Energy production and conversion]; Region: GltP; COG1301
195102003011	Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745
195102003012	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
195102003013	active site
195102003014	phosphorylation site [posttranslational modification]
195102003015	intermolecular recognition site; other site
195102003016	dimerization interface [polypeptide binding]; other site
195102003017	Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383
195102003018	DNA binding site [nucleotide binding]
195102003019	ABC-type multidrug transport system, ATPase component [Defense mechanisms]; Region: CcmA; COG1131
195102003020	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
195102003021	Walker A/P-loop; other site
195102003022	ATP binding site [chemical binding]; other site
195102003023	Q-loop/lid; other site
195102003024	ABC transporter signature motif; other site
195102003025	Walker B; other site
195102003026	D-loop; other site
195102003027	H-loop/switch region; other site
195102003028	ABC-2 family transporter protein; Region: ABC2_membrane_4; pfam12730
195102003029	ABC-2 family transporter protein; Region: ABC2_membrane_2; cl17866
195102003030	Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642
195102003031	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
195102003032	dimer interface [polypeptide binding]; other site
195102003033	phosphorylation site [posttranslational modification]
195102003034	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
195102003035	ATP binding site [chemical binding]; other site
195102003036	Mg2+ binding site [ion binding]; other site
195102003037	G-X-G motif; other site
195102003038	Domain of unknown function (DUF1413); Region: DUF1413; pfam07205
195102003039	flavoprotein, HI0933 family; Region: TIGR00275
195102003040	NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450
195102003041	Glutathione (GSH) peroxidase family; tetrameric selenoenzymes that catalyze the reduction of a variety of hydroperoxides including lipid peroxidases, using GSH as a specific electron donor substrate. GSH peroxidase contains one selenocysteine residue per...; Region: GSH_Peroxidase; cd00340
195102003042	catalytic residues [active]
195102003043	dimer interface [polypeptide binding]; other site
195102003044	Predicted membrane-bound metal-dependent hydrolase (DUF457); Region: DUF457; cl00868
195102003045	Hydrolase of X-linked nucleoside diphosphate N terminal; Region: Nudix_N; pfam12535
195102003046	Members of the Nudix hydrolase superfamily catalyze the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+, for their activity and contain a highly...; Region: Nudix_Hydrolase_14; cd04672
195102003047	nudix motif; other site
195102003048	Pentapeptide repeats (9 copies); Region: Pentapeptide_4; pfam13599
195102003049	Pentapeptide repeats (9 copies); Region: Pentapeptide_4; pfam13599
195102003050	Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805
195102003051	helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347
195102003052	MarR family; Region: MarR; pfam01047
195102003053	inner membrane transporter YjeM; Provisional; Region: PRK15238
195102003054	Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949
195102003055	metal binding site [ion binding]; metal-binding site
195102003056	active site
195102003057	I-site; other site
195102003058	Domain of unknown function (DUF4352); Region: DUF4352; pfam11611
195102003059	Sodium:dicarboxylate symporter family; Region: SDF; pfam00375
195102003060	Na+/H+-dicarboxylate symporters [Energy production and conversion]; Region: GltP; COG1301
195102003061	Predicted membrane protein [Function unknown]; Region: COG1289
195102003062	Fusaric acid resistance protein-like; Region: FUSC_2; pfam13515
195102003063	Kef-type K+ transport systems, membrane components [Inorganic ion transport and metabolism]; Region: KefB; COG0475
195102003064	Sodium/hydrogen exchanger family; Region: Na_H_Exchanger; pfam00999
195102003065	TrkA-C domain; Region: TrkA_C; pfam02080
195102003066	Methyltransferase domain; Region: Methyltransf_32; pfam13679
195102003067	Polymerase and Histidinol Phosphatase domain of Histidinol phosphate phosphatase of Hisj like; Region: PHP_HisPPase_Hisj_like; cd12110
195102003068	histidinol phosphate phosphatase, HisJ family; Region: hisJ_fam; TIGR01856
195102003069	active site
195102003070	dimer interface [polypeptide binding]; other site
195102003071	Lactonase, 7-bladed beta-propeller; Region: Lactonase; pfam10282
195102003072	Tet(M)-like family includes Tet(M), Tet(O), Tet(W), and OtrA, containing tetracycline resistant proteins; Region: TetM_like; cd04168
195102003073	Translation elongation factors (GTPases) [Translation, ribosomal structure and biogenesis]; Region: FusA; COG0480
195102003074	G1 box; other site
195102003075	putative GEF interaction site [polypeptide binding]; other site
195102003076	GTP/Mg2+ binding site [chemical binding]; other site
195102003077	Switch I region; other site
195102003078	G2 box; other site
195102003079	G3 box; other site
195102003080	Switch II region; other site
195102003081	G4 box; other site
195102003082	Translation elongation factors (GTPases) [Translation, ribosomal structure and biogenesis]; Region: FusA; COG0480
195102003083	G5 box; other site
195102003084	EFG_mtEFG_II: this subfamily represents the domain II of elongation factor G (EF-G) in bacteria and, the C-terminus of mitochondrial Elongation factor G1 (mtEFG1) and G2 (mtEFG2)_like proteins found in eukaryotes. During the process of peptide synthesis...; Region: EFG_mtEFG_II; cd04088
195102003085	EF-G_domain IV_RPP domain is a part of bacterial ribosomal protected proteins (RPP) family. RPPs such as tetracycline resistance proteins Tet(M) and Tet(O) mediate tetracycline resistance in both gram-positive and -negative species. Tetracyclines inhibit...; Region: Tet_like_IV; cd01684
195102003086	Tet_C: C-terminus of ribosomal protection proteins Tet(M) and Tet(O). This domain has homology to the C terminal domains of the elongation factors EF-G and EF-2. Tet(M) and Tet(O) catalyze the release of tetracycline (Tc) from the ribosome in a...; Region: Tet_C; cd03711
195102003087	K+ potassium transporter; Region: K_trans; cl15781
195102003088	K+ potassium transporter; Region: K_trans; cl15781
195102003089	nonheme-containing ferritins; Region: Nonheme_Ferritin; cd01055
195102003090	Ferritin-like domain; Region: Ferritin; pfam00210
195102003091	ferroxidase diiron center [ion binding]; other site
195102003092	AraC-like ligand binding domain; Region: AraC_binding; pfam02311
195102003093	helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342
195102003094	Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165
195102003095	Glycosyl hydrolase family 20, catalytic domain; Region: Glyco_hydro_20; pfam00728
195102003096	Glycosyl hydrolase family 20 (GH20) catalytic domain of N-acetyl-beta-D-glucosaminidase (GcnA, also known as BhsA) and related proteins. GcnA  is an exoglucosidase which cleaves N-acetyl-beta-D-galactosamine (NAG) and N-acetyl-beta-D-galactosamine...; Region: GH20_GcnA-like; cd06565
195102003097	putative active site [active]
195102003098	Uncharacterized conserved protein [Function unknown]; Region: COG4127
195102003099	Tim44 is an essential component of the machinery that mediates the translocation of nuclear-encoded proteins across the mitochondrial inner membrane; Region: Tim44; smart00978
195102003100	Bacillus/Clostridium GerA spore germination protein; Region: GerA; pfam03323
195102003101	Predicted membrane protein [Function unknown]; Region: COG1288
195102003102	C4-dicarboxylate anaerobic carrier; Region: DcuC; pfam03606
195102003103	PAS fold; Region: PAS_4; pfam08448
195102003104	phosphate regulon sensor kinase PhoR; Region: phoR_proteo; TIGR02966
195102003105	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
195102003106	putative active site [active]
195102003107	heme pocket [chemical binding]; other site
195102003108	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
195102003109	dimer interface [polypeptide binding]; other site
195102003110	phosphorylation site [posttranslational modification]
195102003111	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
195102003112	ATP binding site [chemical binding]; other site
195102003113	Mg2+ binding site [ion binding]; other site
195102003114	G-X-G motif; other site
195102003115	Phosphotransferase system, EIIC; Region: PTS_EIIC_2; pfam13303
195102003116	Phosphotransferase system, fructose-specific IIC component [Carbohydrate transport and metabolism]; Region: FruA; cl17425
195102003117	L-serine dehydratase, iron-sulfur-dependent, beta subunit; Region: sda_beta; TIGR00719
195102003118	Serine dehydratase beta chain; Region: SDH_beta; pfam03315
195102003119	C-terminal ACT domain of the L-serine dehydratase (LSD), iron-sulfur-dependent, beta subunit; Region: ACT_LSD; cd04903
195102003120	putative L-serine binding site [chemical binding]; other site
195102003121	Serine dehydratase alpha chain; Region: SDH_alpha; cl12120
195102003122	L-serine deaminase [Amino acid transport and metabolism]; Region: SdaA; COG1760
195102003123	This is a subfamily of Adenine nucleotide alpha hydrolases superfamily.Adeninosine nucleotide alpha hydrolases superfamily  includes N type ATP PPases and ATP sulphurylases. It forms a apha/beta/apha fold which  binds to Adenosine group.  This subfamily; Region: Alpha_ANH_like_II; cd01993
195102003124	Ligand Binding Site [chemical binding]; other site
195102003125	tRNA pseudouridine synthase A; Reviewed; Region: PRK12434
195102003126	Eukaryotic and bacterial pseudouridine synthases similar to E.  coli TruA; Region: PseudoU_synth_EcTruA; cd02570
195102003127	dimerization interface 3.5A [polypeptide binding]; other site
195102003128	active site
195102003129	Dioxygenases related to 2-nitropropane dioxygenase [General function prediction only]; Region: COG2070
195102003130	2-Nitropropane dioxygenase (NPD), one of the nitroalkane oxidizing enzyme families, catalyzes oxidative denitrification of nitroalkanes to their corresponding carbonyl compounds and nitrites. NDP is a member of the NAD(P)H-dependent flavin oxidoreductase...; Region: NPD_like; cd04730
195102003131	FMN binding site [chemical binding]; other site
195102003132	substrate binding site [chemical binding]; other site
195102003133	putative catalytic residue [active]
195102003134	cAMP-binding proteins - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases [Signal transduction mechanisms]; Region: Crp; COG0664
195102003135	effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038
195102003136	ligand binding site [chemical binding]; other site
195102003137	flexible hinge region; other site
195102003138	helix_turn_helix, cAMP Regulatory protein C-terminus; DNA binding domain of prokaryotic regulatory proteins belonging to the catabolite activator protein family; Region: HTH_CRP; cd00092
195102003139	non-specific DNA interactions [nucleotide binding]; other site
195102003140	DNA binding site [nucleotide binding]
195102003141	sequence specific DNA binding site [nucleotide binding]; other site
195102003142	putative cAMP binding site [chemical binding]; other site
195102003143	Radical SAM superfamily; Region: Radical_SAM; pfam04055
195102003144	Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335
195102003145	FeS/SAM binding site; other site
195102003146	Cellulase M and related proteins [Carbohydrate transport and metabolism]; Region: FrvX; COG1363
195102003147	M42 Peptidase, Endoglucanase-like subfamily; Region: M42_glucanase_like; cd05657
195102003148	putative oligomer interface [polypeptide binding]; other site
195102003149	putative active site [active]
195102003150	metal binding site [ion binding]; metal-binding site
195102003151	Peptidase MA superfamily; Region: Peptidase_MA_2; pfam13485
195102003152	catalytic core domain of discriminating glutamyl-tRNA synthetase; Region: GluRS_core; cd00808
195102003153	glutamyl-tRNA synthetase; Reviewed; Region: gltX; PRK01406
195102003154	HIGH motif; other site
195102003155	catalytic core domain of discriminating glutamyl-tRNA synthetase; Region: GluRS_core; cd00808
195102003156	active site
195102003157	KMSKS motif; other site
195102003158	Probable zinc-binding domain; Region: zf-trcl; pfam13451
195102003159	Protein of unknown function, DUF488; Region: DUF488; pfam04343
195102003160	aspartate 4-decarboxylase; Region: asp_4_decarbox; TIGR03801
195102003161	Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609
195102003162	pyridoxal 5'-phosphate binding site [chemical binding]; other site
195102003163	homodimer interface [polypeptide binding]; other site
195102003164	catalytic residue [active]
195102003165	Bacterial protein of unknown function (DUF896); Region: DUF896; pfam05979
195102003166	HPr kinase/phosphorylase; Provisional; Region: PRK05428
195102003167	HPr Serine kinase N terminus; Region: Hpr_kinase_N; pfam02603
195102003168	HprK/P, the bifunctional histidine-containing protein kinase/phosphatase, controls the phosphorylation state of the phosphocarrier protein HPr and regulates the utilization of carbon sources by gram-positive bacteria. It catalyzes both the ATP-dependent...; Region: HprK_C; cd01918
195102003169	Hpr binding site; other site
195102003170	active site
195102003171	homohexamer subunit interaction site [polypeptide binding]; other site
195102003172	Thermotoga maritima CorA-like family; Region: TmCorA-like; cd12822
195102003173	CorA-like Mg2+ transporter protein; Region: CorA; pfam01544
195102003174	oligomer interface [polypeptide binding]; other site
195102003175	metal binding site [ion binding]; metal-binding site
195102003176	metal binding site [ion binding]; metal-binding site
195102003177	putative Cl binding site [ion binding]; other site
195102003178	aspartate ring; other site
195102003179	hydrophobic gate; other site
195102003180	periplasmic entrance; other site
195102003181	M18 Peptidase Aminopeptidase I; Region: M18_API; cd05659
195102003182	Aminopeptidase I zinc metalloprotease (M18); Region: Peptidase_M18; pfam02127
195102003183	oligomer interface [polypeptide binding]; other site
195102003184	putative active site [active]
195102003185	metal binding site [ion binding]; metal-binding site
195102003186	c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal    transduction mechanisms]; Region: COG2199
195102003187	Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949
195102003188	metal binding site [ion binding]; metal-binding site
195102003189	active site
195102003190	I-site; other site
195102003191	EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2).  The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948
195102003192	Methylglyoxal synthase catalyzes the enolization of dihydroxyacetone phosphate (DHAP) to produce methylglyoxal. The first part of the catalytic mechanism is believed to be similar to TIM (triosephosphate isomerase) in that both enzymes utilize DHAP to...; Region: MGS; cd01422
195102003193	active site
195102003194	dimer interfaces [polypeptide binding]; other site
195102003195	catalytic residues [active]
195102003196	Bacteriophage holin; Region: Phage_holin_1; cl02344
195102003197	YjgF, YER057c, and UK114 belong to a large family of proteins present in bacteria, archaea, and eukaryotes with no definitive function. The conserved domain is similar in structure to chorismate mutase but there is no sequence similarity and no...; Region: YjgF_YER057c_UK114_family; cd00448
195102003198	homotrimer interaction site [polypeptide binding]; other site
195102003199	putative active site [active]
195102003200	TSCPD domain; Region: TSCPD; cl14834
195102003201	Uncharacterized flavoproteins [Energy production and conversion]; Region: FpaA; COG0426
195102003202	Metallo-beta-lactamase superfamily; Region: Lactamase_B; smart00849
195102003203	Flavodoxin-like fold; Region: Flavodoxin_2; cl00438
195102003204	Rubredoxin, Small Modular nonheme iron binding domain containing a [Fe(SCys)4] center, present in rubrerythrin and nigerythrin and detected either N- or C-terminal to such proteins as flavin reductase, NAD(P)H-nitrite reductase, and...; Region: rubredoxin_SM; cd00729
195102003205	Rubredoxin; Region: Rubredoxin; pfam00301
195102003206	iron binding site [ion binding]; other site
195102003207	Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox_2; pfam07992
195102003208	Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070
195102003209	Predicted metal-dependent phosphoesterases (PHP family) [General function prediction only]; Region: COG0613
195102003210	Polymerase and Histidinol Phosphatase domain of Histidinol phosphate phosphatase (HisPPase) AMP bound; Region: PHP_HisPPase_AMP; cd07438
195102003211	active site
195102003212	Polymerase and Histidinol Phosphatase domain of Histidinol phosphate phosphatase (HisPPase) AMP bound; Region: PHP_HisPPase_AMP; cd07438
195102003213	para-aminobenzoate synthase component II; Provisional; Region: PRK08857
195102003214	Type 1 glutamine amidotransferase (GATase1) domain found in Anthranilate synthase; Region: GATase1_Anthranilate_Synthase; cd01743
195102003215	glutamine binding [chemical binding]; other site
195102003216	catalytic triad [active]
195102003217	Anthranilate/para-aminobenzoate synthases component I [Amino acid transport and metabolism / Coenzyme metabolism]; Region: TrpE; COG0147
195102003218	Anthranilate synthase component I, N terminal region; Region: Anth_synt_I_N; pfam04715
195102003219	chorismate binding enzyme; Region: Chorismate_bind; cl10555
195102003220	PyridoxaL 5'-Phosphate Dependent Enzymes class IV (PLPDE_IV). This D-amino acid superfamily, one of five classes of PLPDE, consists of branched-chain amino acid aminotransferases (BCAT), D-amino acid transferases (DAAT), and...; Region: PLPDE_IV; cd00449
195102003221	homodimer interface [polypeptide binding]; other site
195102003222	Branched-chain amino acid aminotransferase/4-amino-4-deoxychorismate lyase [Amino acid transport and metabolism / Coenzyme metabolism]; Region: IlvE; COG0115
195102003223	substrate-cofactor binding pocket; other site
195102003224	pyridoxal 5'-phosphate binding site [chemical binding]; other site
195102003225	catalytic residue [active]
195102003226	GTP cyclohydrolase I (GTP-CH-I) catalyzes the conversion of GTP into dihydroneopterin triphosphate.  The enzyme product is the precursor of tetrahydrofolate in eubacteria, fungi, and plants and of the folate analogs in methanogenic bacteria.  In...; Region: GTP_cyclohydro1; cd00642
195102003227	homodecamer interface [polypeptide binding]; other site
195102003228	GTP cyclohydrolase I; Provisional; Region: PLN03044
195102003229	active site
195102003230	putative catalytic site residues [active]
195102003231	zinc binding site [ion binding]; other site
195102003232	GTP-CH-I/GFRP interaction surface; other site
195102003233	Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077
195102003234	Zn2+ binding site [ion binding]; other site
195102003235	Mg2+ binding site [ion binding]; other site
195102003236	DHPS subgroup of Pterin binding enzymes. DHPS (dihydropteroate synthase), a functional homodimer, catalyzes the condensation of p-aminobenzoic acid (pABA) in the de novo biosynthesis of folate, which is an essential cofactor in both nucleic acid and...; Region: DHPS; cd00739
195102003237	dihydropteroate synthase; Region: DHPS; TIGR01496
195102003238	substrate binding pocket [chemical binding]; other site
195102003239	dimer interface [polypeptide binding]; other site
195102003240	inhibitor binding site; inhibition site
195102003241	Dihydroneopterin aldolase (DHNA) and 7,8-dihydroneopterin triphosphate epimerase domain (DHNTPE); these enzymes have been designated folB and folX, respectively. Folate derivatives are essential cofactors in the biosynthesis of purines, pyrimidines, and...; Region: DHNA_DHNTPE; cd00534
195102003242	homooctamer interface [polypeptide binding]; other site
195102003243	active site
195102003244	7,8-dihydro-6-hydroxymethylpterin-pyrophosphokinase (HPPK). Folate derivatives are essential cofactors in the biosynthesis of purines, pyrimidines, and amino acids as well as formyl-tRNA. Mammalian cells are able to utilize pre-formed folates after...; Region: HPPK; cd00483
195102003245	catalytic center binding site [active]
195102003246	ATP binding site [chemical binding]; other site
195102003247	Pyruvate kinase (PK):  Large allosteric enzyme that regulates glycolysis through binding of the substrate, phosphoenolpyruvate, and one or more allosteric effectors. Like other allosteric enzymes, PK has a high substrate affinity R state and a low...; Region: Pyruvate_Kinase; cl17342
195102003248	active site
195102003249	domain interfaces; other site
195102003250	PAP2_like_2 proteins. PAP2 is a super-family of phosphatases and haloperoxidases. This subgroup, which is specific to bacteria, lacks functional characterization and may act as a membrane-associated lipid phosphatase; Region: PAP2_like_2; cd03392
195102003251	Membrane-associated phospholipid phosphatase [Lipid metabolism]; Region: PgpB; COG0671
195102003252	active site
195102003253	ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653
195102003254	Domain of unknown function (DUF3502); Region: DUF3502; pfam12010
195102003255	Uncharacterized ACR, COG1993; Region: DUF190; cl00872
195102003256	camphor resistance protein CrcB; Provisional; Region: PRK14199
195102003257	ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653
195102003258	Bacterial extracellular solute-binding protein; Region: SBP_bac_1; pfam01547
195102003259	Domain of unknown function (DUF3502); Region: DUF3502; pfam12010
195102003260	Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090
195102003261	dimerization interface [polypeptide binding]; other site
195102003262	putative DNA binding site [nucleotide binding]; other site
195102003263	putative Zn2+ binding site [ion binding]; other site
195102003264	This uncharacterized conserved protein belongs to a family of iron-molybdenum cluster-binding proteins that includes NifX, NifB, and NifY, all of which are involved in the synthesis of an iron-molybdenum cofactor (FeMo-co) that binds the active site of...; Region: MTH1175; cd00851
195102003265	Metal-dependent amidase/aminoacylase/carboxypeptidase [General function prediction only]; Region: AbgB; COG1473
195102003266	M20 Peptidases Aminoacyclase-1 indole-3-acetic-L-aspartic acid hydrolase from bacteria and archaea; Region: M20_Acy1_IAAspH_bact; cd05665
195102003267	putative metal binding site [ion binding]; other site
195102003268	dimer interface [polypeptide binding]; other site
195102003269	Choline Kinase (ChoK). The ChoK subfamily is part of a larger superfamily that includes the catalytic domains of other kinases, such as the typical serine/threonine/tyrosine protein kinases (PKs), RIO kinases, actin-fragmin kinase (AFK), and...; Region: ChoK; cd05151
195102003270	active site
195102003271	ATP binding site [chemical binding]; other site
195102003272	Phosphotransferase enzyme family; Region: APH; pfam01636
195102003273	substrate binding site [chemical binding]; other site
195102003274	dimer interface [polypeptide binding]; other site
195102003275	Phosphoribosyltransferase; Region: DBI_PRT; pfam02277
195102003276	Nicotinate-nucleotide-dimethylbenzimidazole phosphoribosyltransferase (DMB-PRT), also called CobT; Region: DMB-PRT_CobT; cd02439
195102003277	active site pocket [active]
195102003278	putative dimer interface [polypeptide binding]; other site
195102003279	putative cataytic base [active]
195102003280	Adenosylcobinamide kinase / adenosylcobinamide phosphate guanyltransferase (CobU). CobU is bifunctional cobalbumin biosynthesis enzymes which display adenosylcobinamide kinase and adenosylcobinamide phosphate guanyltransferase activity. This enzyme is a...; Region: CobU; cd00544
195102003281	homotrimer interface [polypeptide binding]; other site
195102003282	Walker A motif; other site
195102003283	GTP binding site [chemical binding]; other site
195102003284	Walker B motif; other site
195102003285	cobalamin synthase; Reviewed; Region: cobS; PRK00235
195102003286	Cobinamide kinase / cobinamide phosphate guanyltransferase; Region: CobU; cl17363
195102003287	Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067
195102003288	catalytic core [active]
195102003289	cobalamin biosynthesis protein; Provisional; Region: cobD; PRK01209
195102003290	threonine-phosphate decarboxylase; Provisional; Region: PRK06358
195102003291	Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609
195102003292	pyridoxal 5'-phosphate binding site [chemical binding]; other site
195102003293	homodimer interface [polypeptide binding]; other site
195102003294	catalytic residue [active]
195102003295	ABC-type Fe3+-hydroxamate transport system, periplasmic component [Inorganic ion transport and metabolism]; Region: FepB; COG0614
195102003296	Periplasmic binding protein YvrC.  These proteins are predicted to function as initial receptors in ABC transport of metal ions in eubacteria and archaea.  They belong to the TroA superfamily of periplasmic metal binding proteins that share a distinct...; Region: YvrC; cd01143
195102003297	putative binding site residues; other site
195102003298	iron-hydroxamate transporter permease subunit; Provisional; Region: PRK10577
195102003299	Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550
195102003300	ABC-ATPase subunit  interface; other site
195102003301	dimer interface [polypeptide binding]; other site
195102003302	putative PBP binding regions; other site
195102003303	ABC-type cobalamin/Fe3+-siderophores transport systems, ATPase components [Inorganic ion transport and metabolism / Coenzyme metabolism]; Region: FepC; COG1120
195102003304	ATP-binding component of iron-siderophores, vitamin B12 and hemin transporters and related proteins; Region: ABC_Iron-Siderophores_B12_Hemin; cd03214
195102003305	Walker A/P-loop; other site
195102003306	ATP binding site [chemical binding]; other site
195102003307	Q-loop/lid; other site
195102003308	ABC transporter signature motif; other site
195102003309	Walker B; other site
195102003310	D-loop; other site
195102003311	H-loop/switch region; other site
195102003312	Predicted ATPases of PP-loop superfamily [General function prediction only]; Region: COG2102
195102003313	This is a subfamily of Adenine nucleotide alpha hydrolases superfamily.Adeninosine nucleotide alpha hydrolases superfamily  includes N type ATP PPases and ATP sulphurylases. It forms a apha/beta/apha fold which  binds to Adenosine group.  This subfamily; Region: Alpha_ANH_like_IV; cd01994
195102003314	Ligand Binding Site [chemical binding]; other site
195102003315	cobyric acid synthase; Provisional; Region: PRK00784
195102003316	Dethiobiotin synthetase [Coenzyme metabolism]; Region: BioD; COG0132
195102003317	Type 1 glutamine amidotransferase (GATase1) domain found in Cobyric Acid Synthase (CobQ); Region: GATase1_CobQ; cd01750
195102003318	catalytic triad [active]
195102003319	Galactose mutarotase-like; Region: Gal_mutarotas_2; pfam13802
195102003320	CPE1046 is an uncharacterized Clostridium perfringens protein with a glycosyl hydrolase family 31 (GH31) domain. The domain architecture of CPE1046 and its orthologs includes a C-terminal fibronectin type 3 (FN3) domain and a coagulation factor 5/8 type...; Region: GH31_CPE1046; cd06596
195102003321	putative active site [active]
195102003322	putative catalytic site [active]
195102003323	Alpha-glucosidases, family 31 of glycosyl hydrolases [Carbohydrate transport and metabolism]; Region: COG1501
195102003324	Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all...; Region: FN3; cd00063
195102003325	Interdomain contacts; other site
195102003326	Cytokine receptor motif; other site
195102003327	Coagulation factor 5/8 C-terminal domain, discoidin domain; Region: FA58C; smart00231
195102003328	F5/8 type C domain; Region: F5_F8_type_C; pfam00754
195102003329	sugar binding site [chemical binding]; other site
195102003330	Cohesin domain, interaction partner of dockerin; Region: Type_III_cohesin_like; cd08759
195102003331	putative dockerin binding interface; other site
195102003332	F5/8 type C domain; Region: F5_F8_type_C; pfam00754
195102003333	sugar binding site [chemical binding]; other site
195102003334	Bacterial surface proteins containing Ig-like domains [Cell motility and secretion]; Region: COG5492
195102003335	Bacterial Ig-like domain (group 2); Region: Big_2; pfam02368
195102003336	Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all...; Region: FN3; cd00063
195102003337	Interdomain contacts; other site
195102003338	Cytokine receptor motif; other site
195102003339	Lysis protein; Region: Lysis_col; pfam02402
195102003340	Thioredoxin-like domain; Region: Thioredoxin_2; pfam13098
195102003341	Methyltransferase domain; Region: Methyltransf_31; pfam13847
195102003342	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
195102003343	S-adenosylmethionine binding site [chemical binding]; other site
195102003344	5'-methylthioadenosine/S-adenosylhomocysteine nucleosidase; Validated; Region: PRK05584
195102003345	5'-methylthioadenosine/S-adenosylhomocysteine nucleosidase; Region: MTA/SAH-Nsdase; TIGR01704
195102003346	Cyclopropane fatty acid synthase and related methyltransferases [Cell envelope biogenesis, outer membrane]; Region: Cfa; COG2230
195102003347	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
195102003348	S-adenosylmethionine binding site [chemical binding]; other site
195102003349	Rhodanese Homology Domain; Region: RHOD; smart00450
195102003350	active site residue [active]
195102003351	Rhodanese-related sulfurtransferase [Inorganic ion transport and metabolism]; Region: SseA; COG2897
195102003352	Thiosulfate sulfurtransferase (TST), N-terminal, inactive domain. TST contains 2 copies of the Rhodanese Homology Domain; this is the 1st repeat, which does not contain the catalytically active Cys residue. The role of the 1st repeat is uncertain, but it...; Region: TST_Repeat_1; cd01448
195102003353	active site residue [active]
195102003354	Thiosulfate sulfurtransferase (TST), C-terminal, catalytic domain. TST contains 2 copies of the Rhodanese Homology Domain; this is the second repeat. Only the second repeat contains the catalytically active Cys residue; Region: TST_Repeat_2; cd01449
195102003355	active site residue [active]
195102003356	Protein of unknown function (DUF1292); Region: DUF1292; pfam06949
195102003357	Exonuclease-Endonuclease-Phosphatase domain; uncharacterized family 1; Region: EEP-1; cd09083
195102003358	putative catalytic site [active]
195102003359	putative metal binding site [ion binding]; other site
195102003360	putative phosphate binding site [ion binding]; other site
195102003361	histidinol-phosphatase; Reviewed; Region: PRK08123
195102003362	Polymerase and Histidinol Phosphatase domain of Histidinol phosphate phosphatase of Hisj like; Region: PHP_HisPPase_Hisj_like; cd12110
195102003363	active site
195102003364	dimer interface [polypeptide binding]; other site
195102003365	Tetratricopeptide repeat; Region: TPR_16; pfam13432
195102003366	tol-pal system protein YbgF; Region: tol_pal_ybgF; TIGR02795
195102003367	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
195102003368	binding surface
195102003369	TPR motif; other site
195102003370	Glutamine aminotransferase (GAT, glutaminase) domain of glutamine-dependent NAD synthetases (class 7 and 8 nitrilases); Region: GAT_Gln-NAD-synth; cd07570
195102003371	multimer interface [polypeptide binding]; other site
195102003372	active site
195102003373	catalytic triad [active]
195102003374	protein interface 1 [polypeptide binding]; other site
195102003375	NAD synthase [Coenzyme metabolism]; Region: NadE; COG0171
195102003376	NAD+ synthase is a homodimer, which catalyzes the final step in de novo nicotinamide adenine dinucleotide (NAD+) biosynthesis, an amide transfer from either ammonia or glutamine to nicotinic acid adenine dinucleotide (NaAD). The conversion of NaAD to NAD...; Region: NAD_synthase; cd00553
195102003377	homodimer interface [polypeptide binding]; other site
195102003378	NAD binding pocket [chemical binding]; other site
195102003379	ATP binding pocket [chemical binding]; other site
195102003380	Mg binding site [ion binding]; other site
195102003381	active-site loop [active]
195102003382	Membrane protein implicated in regulation of membrane protease activity [Posttranslational modification, protein turnover, chaperones / Intracellular trafficking and secretion]; Region: COG1585
195102003383	Membrane protease subunits, stomatin/prohibitin homologs [Posttranslational modification, protein turnover, chaperones]; Region: HflC; COG0330
195102003384	Band_7_stomatin_like: A subgroup of the band 7 domain of flotillin (reggie) like proteins similar to stomatin and podicin (two lipid raft-associated integral membrane proteins). Individual proteins of this band 7 domain family may cluster to form...; Region: Band_7_stomatin_like; cd03403
195102003385	Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzymes; Region: PLPDE_III; cl00261
195102003386	pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site
195102003387	catalytic residue [active]
195102003388	electron transport complex, RnfABCDGE type, G subunit; Region: rnfG; TIGR01947
195102003389	FMN-binding domain; Region: FMN_bind; cl01081
195102003390	electron transport complex RsxE subunit; Provisional; Region: PRK12405
195102003391	electron transport complex, RnfABCDGE type, A subunit; Region: rnfA; TIGR01943
195102003392	ferredoxin; Validated; Region: PRK07118
195102003393	Putative Fe-S cluster; Region: FeS; cl17515
195102003394	RPB11 and RPB3 subunits of RNA polymerase; Region: RNAP_RPB11_RPB3; cl11409
195102003395	RPB11 and RPB3 subunits of RNA polymerase; Region: RNAP_RPB11_RPB3; cl11409
195102003396	Deoxycytidylate deaminase domain. Deoxycytidylate deaminase catalyzes the deamination of dCMP to dUMP, providing the nucleotide substrate for thymidylate synthase. The enzyme binds Zn++, which is required for catalytic activity. The activity of the...; Region: deoxycytidylate_deaminase; cd01286
195102003397	catalytic motif [active]
195102003398	Zn binding site [ion binding]; other site
195102003399	MarR family; Region: MarR_2; pfam12802
195102003400	3-oxoacyl-(acyl carrier protein) synthase III; Reviewed; Region: PRK09352
195102003401	Ketoacyl-acyl carrier protein synthase III (KASIII) initiates the elongation in type II fatty acid synthase systems. It is found in bacteria and plants. Elongation of fatty acids in the type II systems occurs by Claisen condensation of malonyl-acyl...; Region: KAS_III; cd00830
195102003402	dimer interface [polypeptide binding]; other site
195102003403	active site
195102003404	CoA binding pocket [chemical binding]; other site
195102003405	(acyl-carrier-protein) S-malonyltransferase [Lipid metabolism]; Region: FabD; COG0331
195102003406	malonyl CoA-acyl carrier protein transacylase; Region: fabD; TIGR00128
195102003407	beta-Keto acyl carrier protein reductase (BKR), involved in Type II FAS, classical (c) SDRs; Region: BKR_SDR_c; cd05333
195102003408	3-oxoacyl-(acyl-carrier-protein) reductase; Region: 3oxo_ACP_reduc; TIGR01830
195102003409	NAD(P) binding site [chemical binding]; other site
195102003410	homotetramer interface [polypeptide binding]; other site
195102003411	homodimer interface [polypeptide binding]; other site
195102003412	active site
195102003413	beta-ketoacyl-acyl-carrier-protein synthase II; Region: fabF; TIGR03150
195102003414	Beta-ketoacyl-acyl carrier protein (ACP) synthase (KAS), type I and II. KASs are responsible for the elongation steps in fatty acid biosynthesis. KASIII catalyses the initial condensation and KAS I and II catalyze further elongation steps by Claisen...; Region: KAS_I_II; cd00834
195102003415	dimer interface [polypeptide binding]; other site
195102003416	active site
195102003417	acetyl-CoA carboxylase biotin carboxyl carrier protein subunit; Validated; Region: PRK06302
195102003418	The biotinyl-domain or biotin carboxyl carrier protein (BCCP) domain is present in all biotin-dependent enzymes, such as acetyl-CoA carboxylase, pyruvate carboxylase, propionyl-CoA carboxylase, methylcrotonyl-CoA carboxylase, geranyl-CoA carboxylase; Region: biotinyl_domain; cd06850
195102003419	carboxyltransferase (CT) interaction site; other site
195102003420	biotinylation site [posttranslational modification]; other site
195102003421	FabZ is a 17kD beta-hydroxyacyl-acyl carrier protein (ACP) dehydratase that primarily catalyzes the dehydration of beta-hydroxyacyl-ACP to trans-2-acyl-ACP, the third step in the elongation phase of the bacterial/ plastid, type II, fatty-acid...; Region: FabZ; cd01288
195102003422	biotin carboxylase; Validated; Region: PRK05586
195102003423	Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289
195102003424	Carbamoyl-phosphate synthase L chain, ATP binding domain; Region: CPSase_L_D2; pfam02786
195102003425	Biotin carboxylase C-terminal domain; Region: Biotin_carb_C; smart00878
195102003426	malonate decarboxylase subunit beta; Reviewed; Region: PRK07189; cl17682
195102003427	acetyl-CoA carboxylase carboxyltransferase subunit alpha; Validated; Region: PRK05724
195102003428	Predicted transcriptional regulators [Transcription]; Region: COG1695
195102003429	Transcriptional regulator PadR-like family; Region: PadR; cl17335
195102003430	AP endonuclease family 2; These endonucleases play a role in DNA repair. Cleave phosphodiester bonds at apurinic or apyrimidinic sites; the alignment also contains hexulose-6-phosphate isomerases, enzymes that catalyze the epimerization of...; Region: AP2Ec; cd00019
195102003431	Xylose isomerase-like TIM barrel; Region: AP_endonuc_2; pfam01261
195102003432	AP (apurinic/apyrimidinic) site pocket; other site
195102003433	DNA interaction; other site
195102003434	Metal-binding active site; metal-binding site
195102003435	16S rRNA uridine-516 pseudouridylate synthase and related pseudouridylate synthases [Translation, ribosomal structure and biogenesis]; Region: RsuA; COG1187
195102003436	S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site;  Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165
195102003437	RNA binding surface [nucleotide binding]; other site
195102003438	Pseudouridine synthases, RsuA subfamily; Region: PseudoU_synth_RsuA_like; cd02870
195102003439	active site
195102003440	Putative rRNA methylase; Region: rRNA_methylase; pfam06962
195102003441	Transcriptional regulators [Transcription]; Region: RpiR; COG1737
195102003442	Helix-turn-helix domain, rpiR family; Region: HTH_6; pfam01418
195102003443	RpiR-like protein. RpiR contains a SIS (Sugar ISomerase) domain, which is found in many phosphosugar isomerases and phosphosugar binding proteins. In E. coli, rpiR negatively regulates the expression of rpiB gene. Both rpiB and rpiA are ribose phosphate...; Region: SIS_RpiR; cd05013
195102003444	putative active site [active]
195102003445	flavoprotein, HI0933 family; Region: TIGR00275
195102003446	cytidylate kinase; Provisional; Region: cmk; PRK00023
195102003447	Cytidine monophosphate kinase (CMPK) catalyzes the reversible phosphorylation of cytidine monophosphate (CMP) to produce cytidine diphosphate (CDP), using ATP as the preferred phosphoryl donor; Region: CMPK; cd02020
195102003448	CMP-binding site; other site
195102003449	The sites determining sugar specificity; other site
195102003450	4-hydroxy-3-methylbut-2-enyl diphosphate reductase; Provisional; Region: PRK12360
195102003451	(E)-4-hydroxy-3-methyl-but-2-enyl pyrophosphate reductase (IPP and DMAPP forming); Region: ispH_lytB; TIGR00216
195102003452	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301
195102003453	Coenzyme A binding pocket [chemical binding]; other site
195102003454	Helix-turn-helix domain; Region: HTH_17; pfam12728
195102003455	MerR HTH family regulatory protein; Region: MerR_1; pfam13411
195102003456	Linear amide C-N hydrolases, choloylglycine hydrolase family; Region: CBAH; pfam02275
195102003457	The Ntn hydrolases (N-terminal nucleophile) are a diverse superfamily of of enzymes that are activated autocatalytically via an N-terminally lcated nucleophilic amino acid.  N-terminal nucleophile (NTN-) hydrolase superfamily, which contains a...; Region: Ntn_hydrolase; cl00467
195102003458	active site
195102003459	(dimethylallyl)adenosine tRNA methylthiotransferase; Provisional; Region: PRK14328
195102003460	Uncharacterized protein family UPF0004; Region: UPF0004; pfam00919
195102003461	Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335
195102003462	FeS/SAM binding site; other site
195102003463	TRAM domain; Region: TRAM; pfam01938
195102003464	phosphoenolpyruvate carboxylase; Provisional; Region: PRK13655
195102003465	phosphoenolpyruvate carboxylase, archaeal type; Region: PEPCase_arch; TIGR02751
195102003466	Site-specific recombinase XerD [DNA replication, recombination, and repair]; Region: XerD; COG4974
195102003467	DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213
195102003468	active site
195102003469	DNA binding site [nucleotide binding]
195102003470	Int/Topo IB signature motif; other site
195102003471	Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396
195102003472	Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093
195102003473	sequence-specific DNA binding site [nucleotide binding]; other site
195102003474	salt bridge; other site
195102003475	Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093
195102003476	non-specific DNA binding site [nucleotide binding]; other site
195102003477	salt bridge; other site
195102003478	sequence-specific DNA binding site [nucleotide binding]; other site
195102003479	BRO family, N-terminal domain; Region: Bro-N; smart01040
195102003480	HNH endonuclease; Region: HNH; pfam01844
195102003481	active site
195102003482	phage terminase, small subunit, putative, P27 family; Region: sm_term_P27; TIGR01558
195102003483	Phage terminase-like protein, large subunit [General function prediction only]; Region: COG4626
195102003484	Phage-related protein [Function unknown]; Region: COG4695; cl01923
195102003485	phage portal protein, HK97 family; Region: portal_HK97; TIGR01537
195102003486	Caudovirus prohead protease; Region: Peptidase_U35; pfam04586
195102003487	phage major capsid protein, HK97 family; Region: major_cap_HK97; TIGR01554
195102003488	Phage capsid family; Region: Phage_capsid; pfam05065
195102003489	Head-Tail Connector Protein gp6 of Bacteriophage HK97 and similar proteins; Region: gp6; cd08054
195102003490	oligomerization interface [polypeptide binding]; other site
195102003491	phage head-tail adaptor, putative, SPP1 family; Region: gp16_SPP1; TIGR01563
195102003492	phage protein, HK97 gp10 family; Region: phge_HK97_gp10; TIGR01725
195102003493	phage major tail protein, phi13 family; Region: maj_tail_phi13; TIGR01603
195102003494	phage tail tape measure protein, TP901 family, core region; Region: tape_meas_TP901; TIGR01760
195102003495	Phage tail protein; Region: Sipho_tail; cl17486
195102003496	Phage-related protein [Function unknown]; Region: COG4722
195102003497	phage minor structural protein, N-terminal region; Region: put_anti_recept; TIGR01665
195102003498	Cell wall-associated hydrolases (invasion-associated proteins) [Cell envelope biogenesis, outer membrane]; Region: Spr; COG0791
195102003499	NlpC/P60 family; Region: NLPC_P60; pfam00877
195102003500	lysozyme_like domain.  This contains several members including Soluble Lytic Transglycosylases (SLT), Goose Egg-White Lysozymes (GEWL), Hen Egg-White Lysozymes (HEWL), chitinases, bacteriophage lambda lysozymes, endolysins, autolysins, and chitosanases; Region: lysozyme_like; cl00222
195102003501	catalytic residue [active]
195102003502	Metallo-beta-lactamase superfamily; Region: Lactamase_B; smart00849
195102003503	Domain of unknown function (DUF2479); Region: DUF2479; pfam10651
195102003504	Peptidoglycan recognition proteins (PGRPs) are pattern recognition receptors that bind, and in certain cases, hydrolyze peptidoglycans (PGNs) of bacterial cell walls. PGRPs have been divided into three classes: short PGRPs (PGRP-S), that are small (20...; Region: PGRP; cd06583
195102003505	amidase catalytic site [active]
195102003506	Zn binding residues [ion binding]; other site
195102003507	substrate binding site [chemical binding]; other site
195102003508	Transcriptional regulator, contains sigma factor-related N-terminal domain [Transcription]; Region: DeoR; COG2390
195102003509	Putative sugar-binding domain; Region: Sugar-bind; pfam04198
195102003510	ATP:dephospho-CoA triphosphoribosyl transferase; Region: CitG; cl00768
195102003511	Citrate lyase synthetase [Energy production and conversion]; Region: CitC; COG3053
195102003512	Citrate lyase ligase; Region: Citrate_lyase_ligase; cd02169
195102003513	putative active site [active]
195102003514	(T/H)XGH motif; other site
195102003515	citrate lyase acyl carrier protein; Region: citD; TIGR01608
195102003516	citrate lyase, beta subunit; Region: citE; TIGR01588
195102003517	citrate lyase, alpha subunit; Region: citF; TIGR01584
195102003518	Acetyl-CoA hydrolase/transferase C-terminal domain; Region: AcetylCoA_hyd_C; pfam13336
195102003519	holo-ACP synthase CitX; Region: citrate_citX; TIGR03124
195102003520	Malic enzyme [Energy production and conversion]; Region: SfcA; COG0281
195102003521	Malic enzyme, N-terminal domain; Region: malic; pfam00390
195102003522	NAD(P) binding domain of malic enzyme (ME), subgroup 2; Region: NAD_bind_2_malic_enz; cd05311
195102003523	putative NAD(P) binding site [chemical binding]; other site
195102003524	2-hydroxycarboxylate transporter family; Region: 2HCT; pfam03390
195102003525	formate acetyltransferase 1; Region: pyr_form_ly_1; TIGR01255
195102003526	Pyruvate formate lyase 1; Region: PFL1; cd01678
195102003527	coenzyme A binding site [chemical binding]; other site
195102003528	active site
195102003529	catalytic residues [active]
195102003530	glycine loop; other site
195102003531	pyruvate formate-lyase 1-activating enzyme; Region: PFLA; TIGR02493
195102003532	Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335
195102003533	FeS/SAM binding site; other site
195102003534	DNA mismatch repair protein MutS; Provisional; Region: PRK05399
195102003535	MutS domain I; Region: MutS_I; pfam01624
195102003536	MutS domain II; Region: MutS_II; pfam05188
195102003537	MutS domain III; Region: MutS_III; pfam05192
195102003538	ATP-binding cassette domain of MutS1 homolog; Region: ABC_MutS1; cd03284
195102003539	Walker A/P-loop; other site
195102003540	ATP binding site [chemical binding]; other site
195102003541	Q-loop/lid; other site
195102003542	ABC transporter signature motif; other site
195102003543	Walker B; other site
195102003544	D-loop; other site
195102003545	H-loop/switch region; other site
195102003546	DNA mismatch repair protein; Reviewed; Region: mutL; PRK00095
195102003547	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
195102003548	ATP binding site [chemical binding]; other site
195102003549	Mg2+ binding site [ion binding]; other site
195102003550	G-X-G motif; other site
195102003551	MutL_Trans: transducer domain, having a ribosomal S5 domain 2-like fold, conserved in the C-terminal domain of DNA mismatch repair (MutL/MLH1/PMS2) family. This transducer domain is homologous to the second domain of the DNA gyrase B subunit, which is...; Region: MutL_Trans; cd00782
195102003552	ATP binding site [chemical binding]; other site
195102003553	MutL C terminal dimerisation domain; Region: MutL_C; pfam08676
195102003554	tRNA delta(2)-isopentenylpyrophosphate transferase [Translation, ribosomal structure and biogenesis]; Region: MiaA; COG0324
195102003555	tRNA delta(2)-isopentenylpyrophosphate transferase; Reviewed; Region: miaA; PRK00091
195102003556	bacterial Hfq-like; Region: Hfq; cd01716
195102003557	hexamer interface [polypeptide binding]; other site
195102003558	Sm1 motif; other site
195102003559	RNA binding site [nucleotide binding]; other site
195102003560	Sm2 motif; other site
195102003561	Aluminium resistance protein; Region: Alum_res; pfam06838
195102003562	Cystathionine beta-lyase family protein involved in aluminum resistance [Inorganic ion transport and metabolism]; Region: COG4100
195102003563	LexA repressor; Validated; Region: PRK00215
195102003564	Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090
195102003565	putative DNA binding site [nucleotide binding]; other site
195102003566	putative Zn2+ binding site [ion binding]; other site
195102003567	Peptidase S24 LexA-like proteins are involved in the SOS response leading to the repair of single-stranded DNA within the bacterial cell. This family includes: the lambda repressor CI/C2 family and related bacterial prophage repressor proteins; LexA (EC...; Region: S24_LexA-like; cd06529
195102003568	Catalytic site [active]
195102003569	site-specific tyrosine recombinase XerC; Reviewed; Region: xerC; PRK00236
195102003570	DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213
195102003571	active site
195102003572	DNA binding site [nucleotide binding]
195102003573	Int/Topo IB signature motif; other site
195102003574	Protein of unknown function (DUF3892); Region: DUF3892; pfam13031
195102003575	threonine dehydratase; Provisional; Region: PRK08198
195102003576	Threonine dehydratase: The first step in amino acid degradation is the removal of nitrogen. Although the nitrogen atoms of most amino acids are transferred to alpha-ketoglutarate before removal, the alpha-amino group of threonine can be directly...; Region: Thr-dehyd; cd01562
195102003577	tetramer interface [polypeptide binding]; other site
195102003578	pyridoxal 5'-phosphate binding site [chemical binding]; other site
195102003579	catalytic residue [active]
195102003580	C-terminal ACT domain of biodegradative (catabolic) threonine dehydratase II (ThrD-II) and other related ACT domains; Region: ACT_ThrD-II-like; cd04886
195102003581	Amino acid transporters [Amino acid transport and metabolism]; Region: LysP; COG0833
195102003582	Na+/H+-dicarboxylate symporters [Energy production and conversion]; Region: GltP; COG1301
195102003583	Sodium:dicarboxylate symporter family; Region: SDF; pfam00375
195102003584	Predicted membrane protein [Function unknown]; Region: COG2364
195102003585	Uncharacterized BCR, YitT family COG1284; Region: DUF161; pfam02588
195102003586	Nudix hydrolase is a superfamily of enzymes found in all three kingdoms of life, and it catalyzes the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+...; Region: Nudix_Hydrolase; cl00447
195102003587	nudix motif; other site
195102003588	Phosphoserine phosphatase [Amino acid transport and metabolism]; Region: SerB; COG0560
195102003589	Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427
195102003590	motif II; other site
195102003591	ECF-type riboflavin transporter, S component; Region: ECF-ribofla_trS; pfam07155
195102003592	Human Ape1-like subfamily of the ExoIII family purinic/apyrimidinic (AP) endonucleases; Region: Ape1-like_AP-endo; cd09087
195102003593	active site
195102003594	putative catalytic site [active]
195102003595	DNA binding site [nucleotide binding]
195102003596	putative phosphate binding site [ion binding]; other site
195102003597	metal binding site A [ion binding]; metal-binding site
195102003598	AP binding site [nucleotide binding]; other site
195102003599	metal binding site B [ion binding]; metal-binding site
195102003600	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301
195102003601	Coenzyme A binding pocket [chemical binding]; other site
195102003602	Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223
195102003603	active site
195102003604	dihydroorotate dehydrogenase (subfamily 1) family protein; Region: pyrD_sub1_fam; TIGR01037
195102003605	Dihydroorotate dehydrogenase (DHOD) class 1B FMN-binding domain. DHOD catalyzes the oxidation of (S)-dihydroorotate to orotate. This is the fourth step and the only redox reaction in the de novo biosynthesis of UMP, the precursor of all pyrimidine...; Region: DHOD_1B_like; cd04740
195102003606	heterodimer interface [polypeptide binding]; other site
195102003607	active site
195102003608	FMN binding site [chemical binding]; other site
195102003609	homodimer interface [polypeptide binding]; other site
195102003610	substrate binding site [chemical binding]; other site
195102003611	dihydroorotate dehydrogenase electron transfer subunit; Reviewed; Region: PRK00054
195102003612	FAD/NAD binding domain in the electron transfer subunit of dihydroorotate dehydrogenase. Dihydroorotate dehydrogenases (DHODs) catalyze the only redox reaction in pyrimidine de novo biosynthesis. They catalyze the oxidation of (S)-dihydroorotate to...; Region: DHOD_e_trans; cd06218
195102003613	FAD binding pocket [chemical binding]; other site
195102003614	FAD binding motif [chemical binding]; other site
195102003615	phosphate binding motif [ion binding]; other site
195102003616	beta-alpha-beta structure motif; other site
195102003617	NAD binding pocket [chemical binding]; other site
195102003618	Iron coordination center [ion binding]; other site
195102003619	Orotidine 5'-phosphate decarboxylase (ODCase) is a dimeric enzyme that decarboxylates orotidine 5'-monophosphate (OMP) to form uridine 5'-phosphate (UMP), an essential step in the pyrimidine biosynthetic pathway. In mammals, UMP synthase...; Region: OMP_decarboxylase_like; cd04725
195102003620	active site
195102003621	dimer interface [polypeptide binding]; other site
195102003622	dihydroorotase; Validated; Region: pyrC; PRK09357
195102003623	Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281
195102003624	Dihydroorotase (DHOase), subgroup IIa; DHOases catalyze the reversible interconversion of carbamoyl aspartate to dihydroorotate, a key reaction in pyrimidine biosynthesis. This subgroup also contains proteins that lack the active site, like unc-33, a C; Region: DHOase_IIa; cd01317
195102003625	active site
195102003626	Aspartate carbamoyltransferase regulatory chain, metal binding domain; Region: PyrI_C; pfam02748
195102003627	aspartate carbamoyltransferase catalytic subunit; Provisional; Region: pyrB; PRK00856
195102003628	Aspartate/ornithine carbamoyltransferase, carbamoyl-P binding domain; Region: OTCace_N; pfam02729
195102003629	Aspartate/ornithine carbamoyltransferase, Asp/Orn binding domain; Region: OTCace; pfam00185
195102003630	Beta-lactamase enzyme family; Region: Beta-lactamase2; pfam13354
195102003631	6-phosphofructokinase; Region: PFKA_ATP; TIGR02482
195102003632	phosphofructokinase; Region: PFK_mixed; TIGR02483
195102003633	active site
195102003634	ADP/pyrophosphate binding site [chemical binding]; other site
195102003635	dimerization interface [polypeptide binding]; other site
195102003636	allosteric effector site; other site
195102003637	fructose-1,6-bisphosphate binding site; other site
195102003638	undecaprenyl pyrophosphate phosphatase; Reviewed; Region: PRK00281
195102003639	Phosphomannose isomerase [Carbohydrate transport and metabolism]; Region: ManA; COG1482
195102003640	Alpha-Mannosidase Binding Domain of Atg19/34; Region: ABD; cl15429
195102003641	UDP-N-acetylmuramyl tripeptide synthase [Cell envelope biogenesis, outer membrane]; Region: MurE; COG0769
195102003642	Mur ligase middle domain; Region: Mur_ligase_M; pfam08245
195102003643	Domain of unknown function (DUF1727); Region: DUF1727; pfam08353
195102003644	Type 1 glutamine amidotransferase (GATase1) domain found in Cobyric Acid Synthase (CobQ); Region: GATase1_CobQ; cd01750
195102003645	catalytic triad [active]
195102003646	inner membrane transporter YjeM; Provisional; Region: PRK15238
195102003647	Uncharacterized metal-binding protein (DUF2227); Region: DUF2227; pfam09988
195102003648	Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642
195102003649	Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225
195102003650	dimerization interface [polypeptide binding]; other site
195102003651	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
195102003652	dimer interface [polypeptide binding]; other site
195102003653	phosphorylation site [posttranslational modification]
195102003654	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
195102003655	ATP binding site [chemical binding]; other site
195102003656	Mg2+ binding site [ion binding]; other site
195102003657	G-X-G motif; other site
195102003658	Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745
195102003659	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
195102003660	active site
195102003661	phosphorylation site [posttranslational modification]
195102003662	intermolecular recognition site; other site
195102003663	dimerization interface [polypeptide binding]; other site
195102003664	Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383
195102003665	DNA binding site [nucleotide binding]
195102003666	2-hydroxyglutaryl-CoA dehydratase, D-component; Region: HGD-D; pfam06050
195102003667	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3581
195102003668	Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cd00012
195102003669	nucleotide binding site [chemical binding]; other site
195102003670	BadF/BadG/BcrA/BcrD ATPase family; Region: BcrAD_BadFG; cl17271
195102003671	Activator of 2-hydroxyglutaryl-CoA dehydratase (HSP70-class ATPase domain) [Lipid metabolism]; Region: COG1924
195102003672	BadF/BadG/BcrA/BcrD ATPase family; Region: BcrAD_BadFG; cl17271
195102003673	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3580
195102003674	Radical SAM N-terminal; Region: Radical_SAM_N; pfam08497
195102003675	hypothetical protein; Provisional; Region: PRK00955
195102003676	Domain of unknown function (DUF3362); Region: DUF3362; pfam11842
195102003677	Rad3-related DNA helicases [Transcription / DNA replication, recombination, and repair]; Region: DinG; COG1199
195102003678	DEAD/DEAH box helicase; Region: DEAD; pfam00270
195102003679	DEAD_2; Region: DEAD_2; pfam06733
195102003680	Helicase C-terminal domain; Region: Helicase_C_2; pfam13307
195102003681	Multidrug and toxic compound extrusion family and similar proteins; Region: MATE_like; cl09326
195102003682	Na+-driven multidrug efflux pump [Defense mechanisms]; Region: NorM; COG0534
195102003683	Subfamily of the multidrug and toxic compound extrusion (MATE)-like proteins similar to Streptococcus aureus MepA; Region: MATE_MepA_like; cd13143
195102003684	Phosphotransferase enzyme family; Region: APH; pfam01636
195102003685	Aminoglycoside 3'-phosphotransferase (APH) and Choline Kinase (ChoK) family. The APH/ChoK family is part of a larger superfamily that includes the catalytic domains of other kinases, such as the typical serine/threonine/tyrosine protein kinases (PKs)...; Region: APH_ChoK_like; cl17270
195102003686	Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394
195102003687	active site
195102003688	Cation transporter/ATPase, N-terminus; Region: Cation_ATPase_N; pfam00690
195102003689	Cation transport ATPase [Inorganic ion transport and metabolism]; Region: MgtA; COG0474
195102003690	E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122
195102003691	Putative hydrolase of sodium-potassium ATPase alpha subunit; Region: Hydrolase_like2; pfam13246
195102003692	Soluble P-type ATPase [General function prediction only]; Region: COG4087
195102003693	Cation transporting ATPase, C-terminus; Region: Cation_ATPase_C; pfam00689
195102003694	stage V sporulation protein B; Region: spore_V_B; TIGR02900
195102003695	Stage V sporulation protein B, also known as Stage III sporulation protein F, and related proteins; Region: MATE_SpoVB_like; cd13124
195102003696	Pseudouridylate synthases, 23S RNA-specific [Translation, ribosomal structure and biogenesis]; Region: RluA; COG0564
195102003697	S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site;  Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165
195102003698	RNA binding surface [nucleotide binding]; other site
195102003699	Pseudouridine synthase, RsuA/RluD family; Region: PseudoU_synth_RluCD_like; cd02869
195102003700	active site
195102003701	Metal-dependent amidase/aminoacylase/carboxypeptidase [General function prediction only]; Region: AbgB; COG1473
195102003702	M20 Peptidase Aminoacylase 1 family; Region: M20_Acy1; cd03886
195102003703	metal binding site [ion binding]; metal-binding site
195102003704	dimer interface [polypeptide binding]; other site
195102003705	Superfamily I DNA and RNA helicases [DNA replication, recombination, and repair]; Region: UvrD; COG0210
195102003706	DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046
195102003707	ATP binding site [chemical binding]; other site
195102003708	Family description; Region: UvrD_C_2; pfam13538
195102003709	nicotinate phosphoribosyltransferase; Validated; Region: PRK09243
195102003710	Nicotinate phosphoribosyltransferase (NAPRTase), subgroup A. Nicotinate phosphoribosyltransferase catalyses the formation of NAMN and PPi from 5-phosphoribosy -1-pyrophosphate (PRPP) and nicotinic acid, this is the first, and also rate limiting, reaction...; Region: NAPRTase_A; cd01570
195102003711	active site
195102003712	Ferric uptake regulator(Fur) and related metalloregulatory proteins; typically iron-dependent, DNA-binding repressors and activators; Region: Fur_like; cd07153
195102003713	metal binding site 2 [ion binding]; metal-binding site
195102003714	putative DNA binding helix; other site
195102003715	metal binding site 1 [ion binding]; metal-binding site
195102003716	dimer interface [polypeptide binding]; other site
195102003717	structural Zn2+ binding site [ion binding]; other site
195102003718	dipeptidase PepV; Reviewed; Region: PRK07318
195102003719	M20 Peptidase Xaa-His dipeptidase (PepV) degrades hydrophobic dipeptides; Region: M20_PepV; cd03888
195102003720	active site
195102003721	metal binding site [ion binding]; metal-binding site
195102003722	Xanthine/uracil permeases [Nucleotide transport and metabolism]; Region: UraA; COG2233
195102003723	4-hydroxybenzoyl-CoA thioesterase (4HBT). Catalyzes the final step in the 4-chlorobenzoate degradation pathway in which 4-chlorobenzoate is converted to 4-hydroxybenzoate in certain soil-dwelling bacteria. 4HBT forms a homotetramer with four active sites; Region: 4HBT; cd00586
195102003724	ABC-type cobalamin/Fe3+-siderophores transport systems, ATPase components [Inorganic ion transport and metabolism / Coenzyme metabolism]; Region: FepC; COG1120
195102003725	ATP-binding component of iron-siderophores, vitamin B12 and hemin transporters and related proteins; Region: ABC_Iron-Siderophores_B12_Hemin; cd03214
195102003726	Q-loop/lid; other site
195102003727	ABC transporter signature motif; other site
195102003728	Walker B; other site
195102003729	D-loop; other site
195102003730	H-loop/switch region; other site
195102003731	ABC-type cobalamin/Fe3+-siderophores transport systems, ATPase components [Inorganic ion transport and metabolism / Coenzyme metabolism]; Region: FepC; COG1120
195102003732	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
195102003733	Walker A/P-loop; other site
195102003734	ATP binding site [chemical binding]; other site
195102003735	iron-hydroxamate transporter permease subunit; Provisional; Region: PRK10577
195102003736	Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550
195102003737	ABC-ATPase subunit  interface; other site
195102003738	dimer interface [polypeptide binding]; other site
195102003739	putative PBP binding regions; other site
195102003740	ABC-type Fe3+-hydroxamate transport system, periplasmic component [Inorganic ion transport and metabolism]; Region: FepB; COG0614
195102003741	Metal binding protein TroA_a.  These proteins are predicted to function as initial receptors in ABC transport of metal ions in eubacteria. They belong to the TroA superfamily of helical backbone metal receptor proteins that share a distinct fold and...; Region: TroA_a; cd01148
195102003742	putative ligand binding residues [chemical binding]; other site
195102003743	cobalt-precorrin-6x reductase; Reviewed; Region: PRK08057
195102003744	Precorrin-6x reductase [Coenzyme metabolism]; Region: CobK; COG2099
195102003745	Precorrin-3B C(17)-methyltransferase (CobJ/CbiH); Region: Precorrin_3B_C17_MT; cd11646
195102003746	active site
195102003747	SAM binding site [chemical binding]; other site
195102003748	homodimer interface [polypeptide binding]; other site
195102003749	cobalamin biosynthesis protein CbiG; Validated; Region: PRK05788
195102003750	Cobalamin synthesis G N-terminal; Region: CbiG_N; pfam11760
195102003751	Cobalamin biosynthesis central region; Region: CbiG_mid; pfam11761
195102003752	Cobalamin synthesis G C-terminus; Region: CbiG_C; pfam01890
195102003753	Precorrin-4 C11-methyltransferase (CbiF/CobM); Region: Precorrin-4_C11-MT; cd11641
195102003754	active site
195102003755	SAM binding site [chemical binding]; other site
195102003756	homodimer interface [polypeptide binding]; other site
195102003757	Precorrin-2 C20-methyltransferase, also named CobI or CbiL; Region: Precorrin_2_C20_MT; cd11645
195102003758	active site
195102003759	SAM binding site [chemical binding]; other site
195102003760	homodimer interface [polypeptide binding]; other site
195102003761	Precorrin-6B methylase 2 [Coenzyme metabolism]; Region: CobL; COG2242
195102003762	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
195102003763	S-adenosylmethionine binding site [chemical binding]; other site
195102003764	Precorrin-6Y methyltransferase, the cobalamin biosynthesis enzyme CbiE; Region: Precorrin-6Y-methylase; cd11644
195102003765	active site
195102003766	putative homodimer interface [polypeptide binding]; other site
195102003767	SAM binding site [chemical binding]; other site
195102003768	cobalt-precorrin-6A synthase; Reviewed; Region: cbiD; PRK00075
195102003769	precorrin-8X methylmutase; Validated; Region: cbiC; PRK05575
195102003770	cobalt-precorrin-8X methylmutase; Validated; Region: cbiC; cl00913
195102003771	Cobalt chelatase (CbiK); Region: CbiK; pfam06180
195102003772	Anaerobic cobalamin biosynthetic cobalt chelatase (CbiK), N-terminal domain. CbiK is part of the cobalt-early path for cobalamin biosynthesis. It catalyzes the insertion of cobalt into the oxidized form of precorrin-2, factor II (sirohydrochlorin), the...; Region: CbiK_N; cd03412
195102003773	active site
195102003774	C-terminal domain interface [polypeptide binding]; other site
195102003775	Anaerobic cobalamin biosynthetic cobalt chelatase (CbiK), C-terminal domain. CbiK is part of the cobalt-early path for cobalamin biosynthesis. It catalyzes the insertion of cobalt into the oxidized form of precorrin-2, factor II (sirohydrochlorin), the...; Region: CbiK_C; cd03413
195102003776	active site
195102003777	N-terminal domain interface [polypeptide binding]; other site
195102003778	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3883
195102003779	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3584
195102003780	Bacterial SH3 domain; Region: SH3_3; pfam08239
195102003781	Bacterial SH3 domain; Region: SH3_3; pfam08239
195102003782	Bacterial SH3 domain; Region: SH3_3; pfam08239
195102003783	Bacterial SH3 domain; Region: SH3_3; pfam08239
195102003784	Bacterial SH3 domain; Region: SH3_3; pfam08239
195102003785	Bacterial SH3 domain; Region: SH3_3; pfam08239
195102003786	Bacterial SH3 domain; Region: SH3_3; pfam08239
195102003787	Bacterial SH3 domain; Region: SH3_3; pfam08239
195102003788	Bacterial SH3 domain; Region: SH3_3; pfam08239
195102003789	Bacterial SH3 domain; Region: SH3_3; pfam08239
195102003790	Beta- N-acetylglucosaminidase [Carbohydrate transport and metabolism]; Region: LytD; COG4193
195102003791	Mannosyl-glycoprotein endo-beta-N-acetylglucosaminidase; Region: Glucosaminidase; cl17361
195102003792	GGGtGRT protein; Region: GGGtGRT; pfam14057
195102003793	NifU homolog involved in Fe-S cluster formation [Energy production and conversion]; Region: IscU; COG0822
195102003794	Iron-sulfur cluster scaffold-like proteins; Region: IscU_like; cl00528
195102003795	Glycosyl hydrolase family 20, domain 2; Region: Glyco_hydro_20b; pfam02838
195102003796	beta-N-acetylglucosaminidase; Region: NAGidase; pfam07555
195102003797	F5/8 type C domain; Region: F5_F8_type_C; pfam00754
195102003798	sugar binding site [chemical binding]; other site
195102003799	Domains similar to the eukaryotic reeler domain and bacterial cohesins; Region: Reeler_cohesin_like; cd08523
195102003800	Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all...; Region: FN3; cd00063
195102003801	Interdomain contacts; other site
195102003802	Cytokine receptor motif; other site
195102003803	Superoxide dismutase [Inorganic ion transport and metabolism]; Region: SodA; COG0605
195102003804	Iron/manganese superoxide dismutases, alpha-hairpin domain; Region: Sod_Fe_N; pfam00081
195102003805	Iron/manganese superoxide dismutases, C-terminal domain; Region: Sod_Fe_C; pfam02777
195102003806	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
195102003807	Major Facilitator Superfamily; Region: MFS_1; pfam07690
195102003808	putative substrate translocation pore; other site
195102003809	MgtE intracellular N domain; Region: MgtE_N; pfam03448
195102003810	Mg/Co/Ni transporter MgtE (contains CBS domain) [Inorganic ion transport and metabolism]; Region: MgtE; COG2239
195102003811	This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domain in the magnesium transporter, MgtE.  MgtE and its homologs are found in eubacteria, archaebacteria, and eukaryota. Members of this family transport Mg2+ or other...; Region: CBS_pair_Mg_transporter; cd04606
195102003812	Divalent cation transporter; Region: MgtE; pfam01769
195102003813	Uncharacterized conserved protein [Function unknown]; Region: COG1434
195102003814	YdcF-like. YdcF-like is a large family of mainly bacterial proteins, with a few members found in fungi, plants, and archaea. Escherichia coli YdcF has been shown to bind S-adenosyl-L-methionine (AdoMet), but a biochemical function has not been...; Region: YdcF-like; cd06259
195102003815	putative active site [active]
195102003816	Cold-Shock Protein (CSP) contains an S1-like cold-shock domain (CSD) that is found in eukaryotes, prokaryotes, and archaea.  CSP's include the major cold-shock proteins CspA and CspB in bacteria and the eukaryotic gene regulatory factor Y-box...; Region: CSP_CDS; cd04458
195102003817	DNA-binding site [nucleotide binding]; DNA binding site
195102003818	RNA-binding motif; other site
195102003819	Heavy-metal-associated domain (HMA) is a conserved domain of approximately 30 amino acid residues found in a number of proteins that transport or detoxify heavy metals, for example, the CPx-type heavy metal ATPases and copper chaperones. HMA domain...; Region: HMA; cd00371
195102003820	L,D-transpeptidase catalytic domain; Region: YkuD; pfam03734
195102003821	Uncharacterized protein conserved in bacteria [Function unknown]; Region: ErfK; COG1376
195102003822	Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673
195102003823	Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408
195102003824	Predicted integral membrane protein [Function unknown]; Region: COG0392
195102003825	Uncharacterized conserved protein [Function unknown]; Region: COG2898
195102003826	Uncharacterized conserved protein (DUF2156); Region: DUF2156; pfam09924
195102003827	Predicted integral membrane protein [Function unknown]; Region: COG0392
195102003828	Bax inhibitor 1 like; Region: BaxI_1; cl17691
195102003829	Zinc ribbon domain; Region: CxxC_CxxC_SSSS; cl00993
195102003830	putative oxidoreductase; Provisional; Region: PRK12831
195102003831	The HCP family of iron-sulfur proteins includes hybrid cluster protein (HCP), acetyl-CoA synthase (ACS), and carbon monoxide dehydrogenase (CODH), all of which contain [Fe4-S4] metal clusters at their active sites. These proteins have a conserved...; Region: HCP_like; cl14655
195102003832	NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450
195102003833	ferredoxin-NADP(+) reductase subunit alpha; Reviewed; Region: PRK06222
195102003834	FAD/NAD binding domain in the electron transfer subunit of dihydroorotate dehydrogenase-like proteins. Dihydroorotate dehydrogenases (DHODs) catalyze the only redox reaction in pyrimidine de novo biosynthesis. They catalyze the oxidation of (S)...; Region: DHOD_e_trans_like1; cd06219
195102003835	FAD binding pocket [chemical binding]; other site
195102003836	FAD binding motif [chemical binding]; other site
195102003837	phosphate binding motif [ion binding]; other site
195102003838	beta-alpha-beta structure motif; other site
195102003839	NAD binding pocket [chemical binding]; other site
195102003840	Iron coordination center [ion binding]; other site
195102003841	Alcohol dehydrogenase, class IV [Energy production and conversion]; Region: EutG; COG1454
195102003842	NADPH-dependent butanol dehydrogenase involved in the butanol and ethanol formation pathway in bacteria; Region: NADPH_BDH; cd08179
195102003843	putative active site [active]
195102003844	metal binding site [ion binding]; metal-binding site
195102003845	ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653
195102003846	Bacterial extracellular solute-binding protein; Region: SBP_bac_1; pfam01547
195102003847	Domain of unknown function (DUF3502); Region: DUF3502; pfam12010
195102003848	Bacterial SH3 domain; Region: SH3_3; pfam08239
195102003849	Bacterial SH3 domain; Region: SH3_3; pfam08239
195102003850	Bacterial SH3 domain; Region: SH3_3; pfam08239
195102003851	Bacterial SH3 domain; Region: SH3_3; pfam08239
195102003852	Bacterial SH3 domain; Region: SH3_3; pfam08239
195102003853	Bacterial SH3 domain; Region: SH3_3; pfam08239
195102003854	HNH endonuclease; Region: HNH_2; pfam13391
195102003855	Host cell surface-exposed lipoprotein; Region: Lipoprotein_Ltp; pfam07553
195102003856	Host cell surface-exposed lipoprotein; Region: Lipoprotein_Ltp; pfam07553
195102003857	Host cell surface-exposed lipoprotein; Region: Lipoprotein_Ltp; pfam07553
195102003858	Transcription elongation factor, N-terminal; Region: GreA_GreB_N; pfam03449
195102003859	transcription elongation factor GreA; Region: greA; TIGR01462
195102003860	Transcription elongation factor, GreA/GreB, C-term; Region: GreA_GreB; pfam01272
195102003861	Coagulation factor 5/8 C-terminal domain, discoidin domain; Region: FA58C; smart00231
195102003862	F5/8 type C domain; Region: F5_F8_type_C; pfam00754
195102003863	sugar binding site [chemical binding]; other site
195102003864	F5/8 type C domain; Region: F5_F8_type_C; pfam00754
195102003865	Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all...; Region: FN3; cd00063
195102003866	Interdomain contacts; other site
195102003867	Domain of unknown function (DUF4091); Region: DUF4091; pfam13320
195102003868	Beta-galactosidase/beta-glucuronidase [Carbohydrate transport and metabolism]; Region: LacZ; COG3250
195102003869	Glycosyl hydrolases family 2, sugar binding domain; Region: Glyco_hydro_2_N; pfam02837
195102003870	Glycosyl hydrolases family 2; Region: Glyco_hydro_2; pfam00703
195102003871	Glycosyl hydrolases family 2, TIM barrel domain; Region: Glyco_hydro_2_C; pfam02836
195102003872	Bacterial Ig-like domain (group 1); Region: Big_1; cl17740
195102003873	Bacterial Ig-like domain (group 4); Region: Big_4; pfam07532
195102003874	Bacterial Ig-like domain (group 4); Region: Big_4; pfam07532
195102003875	TRZ/ATZ family contains enzymes from the atrazine degradation pathway and related hydrolases. Atrazine, a chlorinated herbizide, can be catabolized by a variety of different bacteria. The first three steps of the atrazine dehalogenation pathway are...; Region: ATZ_TRZ_like; cd01298
195102003876	Cytosine deaminase and related metal-dependent hydrolases [Nucleotide transport and metabolism / General function prediction only]; Region: SsnA; COG0402
195102003877	active site
195102003878	putative substrate binding pocket [chemical binding]; other site
195102003879	Adenine deaminase [Nucleotide transport and metabolism]; Region: AdeC; COG1001
195102003880	Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281
195102003881	Adenine deaminase (AdeC) directly deaminates adenine to form hypoxanthine. This reaction is part of one of the adenine salvage pathways, as well as the degradation pathway. It is important for adenine utilization as a purine, as well as a nitrogen source...; Region: AdeC; cd01295
195102003882	active site
195102003883	Adenine deaminase C-terminal domain; Region: Adenine_deam_C; pfam13382
195102003884	Spermidine/putrescine-binding periplasmic protein [Amino acid transport and metabolism]; Region: PotD; COG0687
195102003885	Bacterial extracellular solute-binding protein; Region: SBP_bac_6; pfam13343
195102003886	ABC-type spermidine/putrescine transport systems, ATPase components [Amino acid transport and metabolism]; Region: PotA; COG3842
195102003887	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
195102003888	Walker A/P-loop; other site
195102003889	ATP binding site [chemical binding]; other site
195102003890	Q-loop/lid; other site
195102003891	ABC transporter signature motif; other site
195102003892	Walker B; other site
195102003893	D-loop; other site
195102003894	H-loop/switch region; other site
195102003895	TOBE domain; Region: TOBE_2; pfam08402
195102003896	ABC-type spermidine/putrescine transport system, permease component II [Amino acid transport and metabolism]; Region: PotC; COG1177
195102003897	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
195102003898	dimer interface [polypeptide binding]; other site
195102003899	conserved gate region; other site
195102003900	putative PBP binding loops; other site
195102003901	ABC-ATPase subunit interface; other site
195102003902	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
195102003903	ABC-ATPase subunit interface; other site
195102003904	putative PBP binding loops; other site
195102003905	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cl00427
195102003906	tRNA-dihydrouridine synthase [Translation, ribosomal structure and biogenesis]; Region: COG0042
195102003907	Dihydrouridine synthase-like (DUS-like) FMN-binding domain. Members of this family catalyze the reduction of the 5,6-double bond of a uridine residue on tRNA. Dihydrouridine modification of tRNA is widely observed in prokaryotes and eukaryotes, and also...; Region: DUS_like_FMN; cd02801
195102003908	FMN binding site [chemical binding]; other site
195102003909	active site
195102003910	catalytic residues [active]
195102003911	substrate binding site [chemical binding]; other site
195102003912	Na+-driven multidrug efflux pump [Defense mechanisms]; Region: NorM; COG0534
195102003913	Subfamily of the multidrug and toxic compound extrusion (MATE)-like proteins similar to Streptococcus aureus MepA; Region: MATE_MepA_like; cd13143
195102003914	Coenzyme PQQ synthesis protein D (PqqD); Region: PqqD; cl05126
195102003915	OPT oligopeptide transporter protein; Region: OPT; pfam03169
195102003916	putative oligopeptide transporter, OPT family; Region: TIGR00733
195102003917	beta-N-acetylglucosaminidase; Region: NAGidase; pfam07555
195102003918	F5/8 type C domain; Region: F5_F8_type_C; pfam00754
195102003919	CD99 antigen like protein 2; Region: CD99L2; pfam12301
195102003920	LPXTG-motif cell wall anchor domain; Region: LPXTG_anchor; TIGR01167
195102003921	F5/8 type C domain; Region: F5_F8_type_C; pfam00754
195102003922	F5/8 type C domain; Region: F5_F8_type_C; pfam00754
195102003923	Peptidase M60-like family; Region: M60-like; pfam13402
195102003924	This novel putative carbohydrate binding module (NPCBM) domain is found at the N-terminus of glycosyl hydrolase family 98 proteins; Region: NPCBM; smart00776
195102003925	This novel putative carbohydrate binding module (NPCBM) domain is found at the N-terminus of glycosyl hydrolase family 98 proteins; Region: NPCBM; smart00776
195102003926	Leucine Rich repeats (2 copies); Region: LRR_4; pfam12799
195102003927	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
195102003928	Major Facilitator Superfamily; Region: MFS_1; pfam07690
195102003929	putative substrate translocation pore; other site
195102003930	Transcriptional regulators [Transcription]; Region: PhnF; COG2188
195102003931	Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377
195102003932	DNA-binding site [nucleotide binding]; DNA binding site
195102003933	Nucleoside permease [Nucleotide transport and metabolism]; Region: NupC; COG1972
195102003934	Na+ dependent nucleoside transporter N-terminus; Region: Nucleos_tra2_N; pfam01773
195102003935	Nucleoside recognition; Region: Gate; pfam07670
195102003936	Na+ dependent nucleoside transporter C-terminus; Region: Nucleos_tra2_C; pfam07662
195102003937	C-terminal processing peptidase family S41; Region: Peptidase_S41; cl02526
195102003938	Active site serine [active]
195102003939	Protein of unknown function (DUF1097); Region: DUF1097; pfam06496
195102003940	KAP family P-loop domain; Region: KAP_NTPase; pfam07693
195102003941	Predicted P-loop ATPase [General function prediction only]; Region: COG4928
195102003942	Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223
195102003943	active site
195102003944	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
195102003945	binding surface
195102003946	TPR motif; other site
195102003947	TPR repeat; Region: TPR_11; pfam13414
195102003948	TPR repeat; Region: TPR_11; pfam13414
195102003949	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
195102003950	binding surface
195102003951	TPR motif; other site
195102003952	TPR repeat; Region: TPR_11; pfam13414
195102003953	Small protein B (SmpB) is a component of the trans-translation system in prokaryotes for releasing stalled ribosome from damaged messenger RNAs; Region: SmpB; cd09294
195102003954	SmpB-tmRNA interface; other site
195102003955	ribonuclease R; Region: RNase_R; TIGR02063
195102003956	Ribonuclease B OB domain; Region: OB_RNB; pfam08206
195102003957	S1_like: Ribosomal protein S1-like RNA-binding domain. Found in a wide variety of RNA-associated proteins. Originally identified in S1 ribosomal protein. This superfamily also contains the Cold Shock Domain (CSD), which is a homolog of the S1 domain; Region: S1_like; cl09927
195102003958	RNB domain; Region: RNB; pfam00773
195102003959	S1_RNase_R: RNase R C-terminal S1 domain. RNase R is a processive 3' to 5' exoribonuclease, which is a homolog of RNase II. RNase R degrades RNA with secondary structure having a 3' overhang of at least 7 nucleotides. RNase R and PNPase...; Region: S1_RNase_R; cd04471
195102003960	RNA binding site [nucleotide binding]; other site
195102003961	Preprotein translocase SecG subunit; Region: SecG; pfam03840
195102003962	enolase; Provisional; Region: eno; PRK00077
195102003963	Enolase: Enolases are homodimeric enzymes that catalyse the reversible dehydration of 2-phospho-D-glycerate to phosphoenolpyruvate as part of the glycolytic and gluconeogenesis pathways. The reaction is facilitated by the presence of metal ions; Region: enolase; cd03313
195102003964	dimer interface [polypeptide binding]; other site
195102003965	metal binding site [ion binding]; metal-binding site
195102003966	substrate binding pocket [chemical binding]; other site
195102003967	glutamate:gamma-aminobutyrate antiporter; Region: 2A0307_GadC; TIGR00910
195102003968	Phosphoglyceromutase [Carbohydrate transport and metabolism]; Region: GpmI; COG0696
195102003969	phosphoglyceromutase; Provisional; Region: PRK05434
195102003970	Triosephosphate isomerase (TIM) is a glycolytic enzyme that catalyzes the interconversion of dihydroxyacetone phosphate and D-glyceraldehyde-3-phosphate. The reaction is very efficient and requires neither cofactors nor metal ions. TIM, usually...; Region: TIM; cd00311
195102003971	triosephosphate isomerase; Provisional; Region: PRK14567
195102003972	substrate binding site [chemical binding]; other site
195102003973	dimer interface [polypeptide binding]; other site
195102003974	catalytic triad [active]
195102003975	Phosphoglycerate kinase; Region: PGK; pfam00162
195102003976	Phosphoglycerate kinase (PGK) is a monomeric enzyme which catalyzes the transfer of the high-energy phosphate group of 1,3-bisphosphoglycerate to ADP, forming ATP and 3-phosphoglycerate. This reaction represents the first of the two substrate-level...; Region: Phosphoglycerate_kinase; cd00318
195102003977	substrate binding site [chemical binding]; other site
195102003978	hinge regions; other site
195102003979	ADP binding site [chemical binding]; other site
195102003980	catalytic site [active]
195102003981	Glyceraldehyde 3-phosphate dehydrogenase, NAD binding domain; Region: Gp_dh_N; pfam00044
195102003982	glyceraldehyde-3-phosphate dehydrogenase, type I; Region: GAPDH-I; TIGR01534
195102003983	Glyceraldehyde 3-phosphate dehydrogenase, C-terminal domain; Region: Gp_dh_C; pfam02800
195102003984	Transcriptional regulator, contains sigma factor-related N-terminal domain [Transcription]; Region: DeoR; COG2390
195102003985	Putative sugar-binding domain; Region: Sugar-bind; pfam04198
195102003986	RNA polymerase factor sigma-54; Reviewed; Region: PRK05932
195102003987	Sigma-54 factor, Activator interacting domain (AID); Region: Sigma54_AID; pfam00309
195102003988	Sigma-54 factor, core binding domain; Region: Sigma54_CBD; pfam04963
195102003989	Sigma-54, DNA binding domain; Region: Sigma54_DBD; pfam04552
195102003990	Uncharacterized ABC-type transport system, periplasmic component/surface lipoprotein [General function prediction only]; Region: Med; COG1744
195102003991	Periplasmic binding domain of basic membrane lipoprotein, PnrA, in Treponema pallidum and its homologs from other bacteria and Archaea; Region: PBP1_BmpA_PnrA_like; cd06354
195102003992	ligand binding site [chemical binding]; other site
195102003993	EDD domain protein, DegV family; Region: DegV; TIGR00762
195102003994	Uncharacterized protein, DegV family COG1307; Region: DegV; pfam02645
195102003995	Predicted rRNA methylase (SpoU class) [Translation, ribosomal structure and biogenesis]; Region: CspR; COG0219
195102003996	haloacid dehalogenase-like hydrolase; Region: Hydrolase_3; pfam08282
195102003997	Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427
195102003998	active site
195102003999	motif I; other site
195102004000	motif II; other site
195102004001	Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427
195102004002	Putative peptidoglycan binding domain; Region: PG_binding_4; pfam12229
195102004003	VanW like protein; Region: VanW; pfam04294
195102004004	G5 domain; Region: G5; pfam07501
195102004005	Endo-N-acetylmuramidases (muramidases) are lysozymes (also referred to as peptidoglycan hydrolases) that degrade bacterial cell walls by catalyzing the hydrolysis of 1,4-beta-linkages between N-acetylmuramic acid and N-acetyl-D-glucosamine residues; Region: GH25_muramidase; cd00599
195102004006	active site
195102004007	D-alanine--D-alanine ligase; Reviewed; Region: ddl; PRK01372
195102004008	D-ala D-ala ligase N-terminus; Region: Dala_Dala_lig_N; pfam01820
195102004009	ATP-grasp domain; Region: ATP-grasp_4; cl17255
195102004010	phosphate regulon sensor kinase PhoR; Region: phoR_proteo; TIGR02966
195102004011	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
195102004012	putative active site [active]
195102004013	heme pocket [chemical binding]; other site
195102004014	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
195102004015	dimer interface [polypeptide binding]; other site
195102004016	phosphorylation site [posttranslational modification]
195102004017	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
195102004018	ATP binding site [chemical binding]; other site
195102004019	Mg2+ binding site [ion binding]; other site
195102004020	G-X-G motif; other site
195102004021	Permeases of the drug/metabolite transporter (DMT) superfamily [Carbohydrate transport and metabolism / Amino acid transport and metabolism / General function prediction only]; Region: RhaT; COG0697
195102004022	EamA-like transporter family; Region: EamA; pfam00892
195102004023	Predicted EndoIII-related endonuclease [DNA replication, recombination, and repair]; Region: Nth; COG0177
195102004024	endonuclease III; includes endonuclease III (DNA-(apurinic or apyrimidinic site) lyase), alkylbase DNA glycosidases (Alka-family) and other DNA glycosidases; Region: ENDO3c; cd00056
195102004025	minor groove reading motif; other site
195102004026	helix-hairpin-helix signature motif; other site
195102004027	substrate binding pocket [chemical binding]; other site
195102004028	active site
195102004029	Iron-sulfur binding domain of endonuclease III; Region: EndIII_4Fe-2S; pfam10576
195102004030	1-acyl-sn-glycerol-3-phosphate acyltransferase [Lipid metabolism]; Region: PlsC; COG0204
195102004031	Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: AGPAT-like; Region: LPLAT_AGPAT-like; cd07989
195102004032	putative acyl-acceptor binding pocket; other site
195102004033	Uncharacterized Fe-S protein [Energy production and conversion]; Region: COG1600
195102004034	Domain of unknown function (DUF1730); Region: DUF1730; pfam08331
195102004035	serine O-acetyltransferase; Region: cysE; TIGR01172
195102004036	Serine acetyltransferase (SAT): SAT catalyzes the CoA-dependent acetylation of the side chain hydroxyl group of L-serine to form O-acetylserine, as the first step of a two-step biosynthetic pathway in bacteria and plants leading to the formation of...; Region: LbH_SAT; cd03354
195102004037	trimer interface [polypeptide binding]; other site
195102004038	active site
195102004039	substrate binding site [chemical binding]; other site
195102004040	CoA binding site [chemical binding]; other site
195102004041	Cysteine synthase [Amino acid transport and metabolism]; Region: CysK; COG0031
195102004042	CBS_like: This subgroup includes Cystathionine beta-synthase (CBS) and Cysteine synthase. CBS is a unique heme-containing enzyme that catalyzes a pyridoxal 5'-phosphate (PLP)-dependent condensation of serine and homocysteine to give cystathionine; Region: CBS_like; cd01561
195102004043	dimer interface [polypeptide binding]; other site
195102004044	pyridoxal 5'-phosphate binding site [chemical binding]; other site
195102004045	catalytic residue [active]
195102004046	PRC-barrel domain; Region: PRC; pfam05239
195102004047	MgtE intracellular N domain; Region: MgtE_N; smart00924
195102004048	FOG: CBS domain [General function prediction only]; Region: COG0517
195102004049	This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domain in the magnesium transporter, MgtE.  MgtE and its homologs are found in eubacteria, archaebacteria, and eukaryota. Members of this family transport Mg2+ or other...; Region: CBS_pair_Mg_transporter; cd04606
195102004050	Bacterial extracellular solute-binding proteins, family 3; Region: SBP_bac_3; pfam00497
195102004051	Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of  substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134
195102004052	substrate binding pocket [chemical binding]; other site
195102004053	membrane-bound complex binding site; other site
195102004054	hinge residues; other site
195102004055	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
195102004056	dimer interface [polypeptide binding]; other site
195102004057	conserved gate region; other site
195102004058	putative PBP binding loops; other site
195102004059	ABC-ATPase subunit interface; other site
195102004060	ABC-type polar amino acid transport system, ATPase component [Amino acid transport and metabolism]; Region: GlnQ; COG1126
195102004061	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
195102004062	Walker A/P-loop; other site
195102004063	ATP binding site [chemical binding]; other site
195102004064	Q-loop/lid; other site
195102004065	ABC transporter signature motif; other site
195102004066	Walker B; other site
195102004067	D-loop; other site
195102004068	H-loop/switch region; other site
195102004069	putative lipid kinase; Reviewed; Region: PRK13059
195102004070	Diacylglycerol kinase catalytic domain; Region: DAGK_cat; pfam00781
195102004071	CDP-alcohol phosphatidyltransferase; Region: CDP-OH_P_transf; pfam01066
195102004072	CDP-diacylglycerol--serine O-phosphatidyltransferase; Region: pssA; TIGR00473
195102004073	Domain of Unknown Function (DUF1041); Region: DUF1041; pfam06292
195102004074	Rubrerythrin [Energy production and conversion]; Region: COG1592
195102004075	Rubrerythrin, ferritin-like diiron-binding domain; Region: Rubrerythrin; cd01041
195102004076	binuclear metal center [ion binding]; other site
195102004077	Rubredoxin, Small Modular nonheme iron binding domain containing a [Fe(SCys)4] center, present in rubrerythrin and nigerythrin and detected either N- or C-terminal to such proteins as flavin reductase, NAD(P)H-nitrite reductase, and...; Region: rubredoxin_SM; cd00729
195102004078	iron binding site [ion binding]; other site
195102004079	SpoVR like protein; Region: SpoVR; pfam04293
195102004080	Uncharacterized conserved protein [Function unknown]; Region: SpoVR; COG2719
195102004081	Von Willebrand factor type A (vWA) domain was originally found in the blood coagulation protein von Willebrand factor (vWF). Typically, the vWA domain is made up of approximately 200 amino acid residues folded into a classic a/b para-rossmann type of...; Region: vWFA; cd00198
195102004082	metal ion-dependent adhesion site (MIDAS); other site
195102004083	Putative Ser protein kinase [Signal transduction mechanisms]; Region: PrkA; COG2766
195102004084	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cl17189
195102004085	PrkA serine protein kinase C-terminal domain; Region: PrkA; pfam06798
195102004086	ATP-dependent DNA helicase RecQ; Region: recQ; TIGR01389
195102004087	DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046
195102004088	ATP binding site [chemical binding]; other site
195102004089	putative Mg++ binding site [ion binding]; other site
195102004090	Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079
195102004091	nucleotide binding region [chemical binding]; other site
195102004092	ATP-binding site [chemical binding]; other site
195102004093	This DNA-binding domain is found in the RecQ helicase among others and has a helix-turn-helix structure; Region: RQC; smart00956
195102004094	HRDC domain; Region: HRDC; pfam00570
195102004095	Thiamine monophosphate synthase (TMP synthase)/TenI. TMP synthase catalyzes an important step in the thiamine biosynthesis pathway, the substitution of the pyrophosphate of 2-methyl-4-amino-5- hydroxymethylpyrimidine pyrophosphate by 4-methyl-5-; Region: TMP_TenI; cd00564
195102004096	thiamine phosphate binding site [chemical binding]; other site
195102004097	active site
195102004098	pyrophosphate binding site [ion binding]; other site
195102004099	4-methyl-5-beta-hydroxyethylthiazole (Thz) kinase catalyzes the phosphorylation of the hydroxylgroup of Thz. A reaction that allows cells to recycle Thz into the thiamine biosynthesis pathway, as an alternative to its synthesis from cysteine, tyrosine...; Region: THZ_kinase; cd01170
195102004100	substrate binding site [chemical binding]; other site
195102004101	multimerization interface [polypeptide binding]; other site
195102004102	ATP binding site [chemical binding]; other site
195102004103	4-amino-5-hydroxymethyl-2-methyl-pyrimidine phosphate kinase (HMPP-kinase) catalyzes two consecutive phosphorylation steps in the thiamine phosphate biosynthesis pathway, leading to the synthesis of vitamin B1. The first step is the phosphorylation of...; Region: HMPP_kinase; cd01169
195102004104	dimer interface [polypeptide binding]; other site
195102004105	substrate binding site [chemical binding]; other site
195102004106	ATP binding site [chemical binding]; other site
195102004107	Predicted esterase of the alpha-beta hydrolase superfamily [General function prediction only]; Region: COG4667
195102004108	Hypothetical patatin similar to yjju protein of Escherichia coli; Region: Pat_hypo_Ecoli_yjju_like; cd07208
195102004109	active site
195102004110	nucleophile elbow; other site
195102004111	Transcriptional regulators [Transcription]; Region: PurR; COG1609
195102004112	Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392
195102004113	DNA binding site [nucleotide binding]
195102004114	Ligand-binding domain of DNA transcription repressor GalR which is one of two regulatory proteins involved in galactose transport and metabolism; Region: PBP1_GalR; cd01544
195102004115	putative dimerization interface [polypeptide binding]; other site
195102004116	putative ligand binding site [chemical binding]; other site
195102004117	methyl-galactoside ABC transporter galactose-binding periplasmic protein MglB; Provisional; Region: PRK15395
195102004118	Periplasmic glucose/galactose-binding protein (GGBP) involved in chemotaxis towards, and active transport of, glucose and galactose in various bacterial species; Region: PBP1_GGBP; cd01539
195102004119	ligand binding site [chemical binding]; other site
195102004120	calcium binding site [ion binding]; other site
195102004121	First domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_I; cd03216
195102004122	galactose/methyl galaxtoside transporter ATP-binding protein; Provisional; Region: PRK10982
195102004123	Walker A/P-loop; other site
195102004124	ATP binding site [chemical binding]; other site
195102004125	Q-loop/lid; other site
195102004126	ABC transporter signature motif; other site
195102004127	Walker B; other site
195102004128	D-loop; other site
195102004129	H-loop/switch region; other site
195102004130	Second domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_II; cd03215
195102004131	Transmembrane subunit (TM) of Escherichia coli AraH and related proteins. E. coli AraH is the TM of a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of the monosaccharide arabinose. This group...; Region: TM_PBP1_transp_AraH_like; cd06579
195102004132	Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653
195102004133	TM-ABC transporter signature motif; other site
195102004134	galactose mutarotase_like; Region: galactose_mutarotase_like; cd09019
195102004135	active site
195102004136	catalytic residues [active]
195102004137	galactokinase; Provisional; Region: PRK05322
195102004138	Galactokinase galactose-binding signature; Region: GalKase_gal_bdg; pfam10509
195102004139	GHMP kinases N terminal domain; Region: GHMP_kinases_N; pfam00288
195102004140	GHMP kinases C terminal; Region: GHMP_kinases_C; pfam08544
195102004141	galactose-1-phosphate uridylyltransferase; Provisional; Region: PRK05270
195102004142	Galactose-1-phosphate uridyl transferase, N-terminal domain; Region: GalP_UDP_transf; pfam01087
195102004143	Galactose-1-phosphate uridyl transferase, C-terminal domain; Region: GalP_UDP_tr_C; pfam02744
195102004144	Uridine kinase [Nucleotide transport and metabolism]; Region: Udk; COG0572
195102004145	Uridine monophosphate kinase_like (UMPK_like) is a family of proteins highly similar to the uridine monophosphate kinase (UMPK, EC 2.7.1.48), also known as uridine kinase or uridine-cytidine kinase (UCK); Region: UMPK_like; cd02028
195102004146	active site
195102004147	Predicted membrane protein [Function unknown]; Region: COG2323
195102004148	Domain of unknown function (DUF4363); Region: DUF4363; pfam14276
195102004149	Tagatose-1,6-bisphosphate (TBP) aldolase and related Type B Class II aldolases. TBP aldolase is a tetrameric class II aldolase that catalyzes the reversible condensation of dihydroxyacetone phosphate with glyceraldehyde 3-phsophate to produce tagatose 1; Region: TBP_aldolase_IIB; cd00947
195102004150	fructose-bisphosphate aldolase; Provisional; Region: PRK09197
195102004151	intersubunit interface [polypeptide binding]; other site
195102004152	active site
195102004153	zinc binding site [ion binding]; other site
195102004154	Na+ binding site [ion binding]; other site
195102004155	37-kD nucleoid-associated bacterial protein; Region: NA37; pfam04245
195102004156	Adenylyl cyclase (AC) class IV-like, a subgroup of the CYTH-like superfamily; Region: CYTH-like_AC_IV-like; cd07890
195102004157	putative active site [active]
195102004158	putative metal binding residues [ion binding]; other site
195102004159	putative triphosphate binding site [ion binding]; other site
195102004160	signature motif; other site
195102004161	dimer interface [polypeptide binding]; other site
195102004162	Bacterial SH3 domain; Region: SH3_3; pfam08239
195102004163	Bacterial SH3 domain; Region: SH3_3; pfam08239
195102004164	Bacterial SH3 domain; Region: SH3_3; pfam08239
195102004165	Cell wall-associated hydrolases (invasion-associated proteins) [Cell envelope biogenesis, outer membrane]; Region: Spr; COG0791
195102004166	NlpC/P60 family; Region: NLPC_P60; pfam00877
195102004167	Uncharacterized conserved protein (DUF2164); Region: DUF2164; cl02278
195102004168	This CD includes cysteinyl-tRNA(Pro) deacylases from Haemophilus influenzae and Escherichia coli and other related bacterial proteins. These trans-acting, single-domain proteins are homologs of ProX and also the cis-acting prolyl-tRNA synthetase (ProRS)...; Region: YbaK_deacylase; cd00002
195102004169	putative deacylase active site [active]
195102004170	Endo-N-acetylmuramidases (muramidases) are lysozymes (also referred to as peptidoglycan hydrolases) that degrade bacterial cell walls by catalyzing the hydrolysis of 1,4-beta-linkages between N-acetylmuramic acid and N-acetyl-D-glucosamine residues; Region: GH25_muramidase; cl10448
195102004171	active site
195102004172	Bacterial SH3 domain; Region: SH3_3; cl17532
195102004173	hypothetical protein; Provisional; Region: PRK01184
195102004174	Nucleoside/nucleotide kinase (NK) is a protein superfamily consisting of multiple families of enzymes that share structural similarity and are functionally related to the catalysis of the reversible phosphate group transfer from nucleoside triphosphates...; Region: NK; cl17190
195102004175	ribonuclease Z; Region: RNase_Z; TIGR02651
195102004176	F5/8 type C domain; Region: F5_F8_type_C; pfam00754
195102004177	F5/8 type C domain; Region: F5_F8_type_C; pfam00754
195102004178	sugar binding site [chemical binding]; other site
195102004179	Glycosyl hydrolase family 20, catalytic domain; Region: Glyco_hydro_20; pfam00728
195102004180	Glycosyl hydrolase family 20 (GH20) catalytic domain of dispersin B (DspB), lacto-N-biosidase (LnbB) and related proteins. Dispersin B is a soluble beta-N-acetylglucosamidase found in bacteria that hydrolyzes the beta-1,6-linkages of PGA (poly-beta-(1,6)...; Region: GH20_DspB_LnbB-like; cd06564
195102004181	active site
195102004182	Concanavalin A-like lectin/glucanases superfamily; Region: Laminin_G_3; pfam13385
195102004183	F5/8 type C domain; Region: F5_F8_type_C; pfam00754
195102004184	sugar binding site [chemical binding]; other site
195102004185	Type II cohesin domain, interaction partner of dockerin; Region: Type_II_cohesin; cd08547
195102004186	dockerin binding interface; other site
195102004187	Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all...; Region: FN3; cd00063
195102004188	Interdomain contacts; other site
195102004189	Cytokine receptor motif; other site
195102004190	Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377
195102004191	DNA-binding site [nucleotide binding]; DNA binding site
195102004192	TrkA-C domain; Region: TrkA_C; pfam02080
195102004193	Circularly permuted YlqF-related GTPases; Region: YlqF_related_GTPase; cl17249
195102004194	G5 box; other site
195102004195	YibE/F-like protein; Region: YibE_F; pfam07907
195102004196	Lamin Tail Domain; Region: LTD; pfam00932
195102004197	OB-fold nucleic acid binding domain; Region: tRNA_anti; pfam01336
195102004198	Protein of unknown function (DUF3604); Region: DUF3604; pfam12228
195102004199	LPXTG-motif cell wall anchor domain; Region: LPXTG_anchor; TIGR01167
195102004200	Histone acetyltransferase HPA2 and related acetyltransferases [Transcription / General function prediction only]; Region: WecD; COG0454
195102004201	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301
195102004202	Coenzyme A binding pocket [chemical binding]; other site
195102004203	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl17182
195102004204	Polymerase and Histidinol Phosphatase domain of Histidinol phosphate phosphatase of Hisj like; Region: PHP_HisPPase_Hisj_like; cd12110
195102004205	histidinol phosphate phosphatase, HisJ family; Region: hisJ_fam; TIGR01856
195102004206	active site
195102004207	dimer interface [polypeptide binding]; other site
195102004208	solute carrier 6 subfamily, Fusobacterium nucleatum Tyt1-like; solute-binding domain; Region: SLC6sbd_Tyt1-Like; cd10336
195102004209	Na2 binding site [ion binding]; other site
195102004210	putative substrate binding site 1 [chemical binding]; other site
195102004211	Na binding site 1 [ion binding]; other site
195102004212	putative substrate binding site 2 [chemical binding]; other site
195102004213	Protein of unknown function (DUF3816); Region: DUF3816; pfam12822
195102004214	Thiamine transporter protein (Thia_YuaJ); Region: Thia_YuaJ; pfam09515
195102004215	threonine-phosphate decarboxylase; Provisional; Region: PRK06358
195102004216	Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609
195102004217	pyridoxal 5'-phosphate binding site [chemical binding]; other site
195102004218	homodimer interface [polypeptide binding]; other site
195102004219	catalytic residue [active]
195102004220	calcium/proton exchanger (cax); Region: cax; TIGR00378
195102004221	Sodium/calcium exchanger protein; Region: Na_Ca_ex; pfam01699
195102004222	Sodium/calcium exchanger protein; Region: Na_Ca_ex; pfam01699
195102004223	Uncharacterized conserved protein [Function unknown]; Region: COG3379
195102004224	Type I phosphodiesterase / nucleotide pyrophosphatase; Region: Phosphodiest; pfam01663
195102004225	Domain of unknown function (DUF368); Region: DUF368; pfam04018
195102004226	D-alanyl-D-alanine carboxypeptidase [Cell envelope biogenesis, outer membrane]; Region: VanY; COG1876
195102004227	D-alanyl-D-alanine carboxypeptidase; Region: VanY; pfam02557
195102004228	methionine aminopeptidase; Provisional; Region: PRK12318
195102004229	SEC-C motif; Region: SEC-C; pfam02810
195102004230	Methionine Aminopeptidase 1. E.C. 3.4.11.18. Also known as methionyl aminopeptidase and Peptidase M. Catalyzes release of N-terminal amino acids, preferentially methionine, from peptides and arylamides; Region: MetAP1; cd01086
195102004231	active site
195102004232	Zinc dependent phospholipase C; Region: Zn_dep_PLPC; pfam00882
195102004233	YihA (EngB) GTPase family; Region: YihA_EngB; cd01876
195102004234	G1 box; other site
195102004235	GTP/Mg2+ binding site [chemical binding]; other site
195102004236	Switch I region; other site
195102004237	G2 box; other site
195102004238	G3 box; other site
195102004239	Switch II region; other site
195102004240	G4 box; other site
195102004241	G5 box; other site
195102004242	ATP-dependent Lon protease, bacterial type [Posttranslational modification, protein turnover, chaperones]; Region: Lon; COG0466
195102004243	Found in ATP-dependent protease La (LON); Region: LON; smart00464
195102004244	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
195102004245	Walker A motif; other site
195102004246	ATP binding site [chemical binding]; other site
195102004247	Walker B motif; other site
195102004248	arginine finger; other site
195102004249	Lon protease (S16) C-terminal proteolytic domain; Region: Lon_C; pfam05362
195102004250	ATP-dependent protease LonB; Region: spore_lonB; TIGR02902
195102004251	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
195102004252	Walker A motif; other site
195102004253	ATP binding site [chemical binding]; other site
195102004254	Walker B motif; other site
195102004255	arginine finger; other site
195102004256	Lon protease (S16) C-terminal proteolytic domain; Region: Lon_C; pfam05362
195102004257	ATP-dependent protease ATP-binding subunit ClpX; Provisional; Region: clpX; PRK05342
195102004258	ClpX C4-type zinc finger; Region: zf-C4_ClpX; pfam06689
195102004259	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
195102004260	Walker A motif; other site
195102004261	ATP binding site [chemical binding]; other site
195102004262	Walker B motif; other site
195102004263	C-terminal, D2-small domain, of ClpB protein; Region: ClpB_D2-small; smart01086
195102004264	Clp protease; Region: CLP_protease; pfam00574
195102004265	Caseinolytic protease (ClpP) is an ATP-dependent, highly conserved serine protease; Region: S14_ClpP_2; cd07017
195102004266	oligomer interface [polypeptide binding]; other site
195102004267	active site residues [active]
195102004268	trigger factor; Provisional; Region: tig; PRK01490
195102004269	FKBP-type peptidyl-prolyl cis-trans isomerase; Region: FKBP_C; pfam00254
195102004270	Bacterial trigger factor protein (TF) C-terminus; Region: Trigger_C; pfam05698
195102004271	Sugar phosphate isomerases/epimerases [Carbohydrate transport and metabolism]; Region: IolE; COG1082
195102004272	AP endonuclease family 2; These endonucleases play a role in DNA repair. Cleave phosphodiester bonds at apurinic or apyrimidinic sites; the alignment also contains hexulose-6-phosphate isomerases, enzymes that catalyze the epimerization of...; Region: AP2Ec; cl12060
195102004273	AP (apurinic/apyrimidinic) site pocket; other site
195102004274	DNA interaction; other site
195102004275	Metal-binding active site; metal-binding site
195102004276	Superfamily II DNA and RNA helicases [DNA replication, recombination, and repair / Transcription / Translation, ribosomal structure and biogenesis]; Region: SrmB; COG0513
195102004277	DEAD-box helicases. A diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker  B motif; Region: DEADc; cd00268
195102004278	ATP binding site [chemical binding]; other site
195102004279	Mg++ binding site [ion binding]; other site
195102004280	motif III; other site
195102004281	Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079
195102004282	nucleotide binding region [chemical binding]; other site
195102004283	ATP-binding site [chemical binding]; other site
195102004284	RNA recognition motif in the DbpA subfamily of prokaryotic DEAD-box rRNA helicases; Region: RRM_DbpA; cd12252
195102004285	RNA binding site [nucleotide binding]; other site
195102004286	purine nucleoside phosphorylase; Reviewed; Region: deoD; PRK05819
195102004287	Uridine phosphorylase [Nucleotide transport and metabolism]; Region: Udp; COG2820
195102004288	Predicted membrane protein [Function unknown]; Region: COG4640
195102004289	PEGA domain; Region: PEGA; pfam08308
195102004290	DNA polymerase III subunit epsilon; Validated; Region: PRK06195
195102004291	an uncharacterized bacterial subgroup of the DEDDh 3'-5' exonuclease domain family with similarity to the epsilon subunit of DNA polymerase III; Region: DNA_pol_III_epsilon_like; cd06130
195102004292	active site
195102004293	catalytic site [active]
195102004294	substrate binding site [chemical binding]; other site
195102004295	Breast Cancer Suppressor Protein (BRCA1), carboxy-terminal domain. The BRCT domain is found within many DNA damage repair and cell cycle checkpoint proteins. The unique diversity of this domain superfamily allows BRCT modules to interact forming homo...; Region: BRCT; cd00027
195102004296	Dimer interface [polypeptide binding]; other site
195102004297	BRCT sequence motif; other site
195102004298	Predicted Zn-dependent peptidases, insulinase-like [General function prediction only]; Region: COG1026
195102004299	Insulinase (Peptidase family M16); Region: Peptidase_M16; pfam00675
195102004300	Peptidase M16 inactive domain; Region: Peptidase_M16_C; pfam05193
195102004301	Peptidase M16C associated; Region: M16C_assoc; pfam08367
195102004302	Peptidase M16 inactive domain; Region: Peptidase_M16_C; pfam05193
195102004303	Putative amidase domain; Region: Amidase_6; pfam12671
195102004304	N-acetylmuramoyl-L-alanine amidase [Cell envelope biogenesis, outer membrane]; Region: AmiC; COG0860
195102004305	N-acetylmuramoyl-L-alanine amidase or MurNAc-LAA (also known as peptidoglycan aminohydrolase, NAMLA amidase, NAMLAA, Amidase 3, and peptidoglycan amidase; EC 3.5.1.28) is an autolysin that hydrolyzes the amide bond between N-acetylmuramoyl and L-amino...; Region: MurNAc-LAA; cd02696
195102004306	active site
195102004307	metal binding site [ion binding]; metal-binding site
195102004308	Flavin Reductases; Region: FlaRed; cl00801
195102004309	Conserved protein/domain typically associated with flavoprotein oxygenases, DIM6/NTAB family [General function prediction only]; Region: COG1853
195102004310	Chloride channel protein EriC [Inorganic ion transport and metabolism]; Region: EriC; COG0038
195102004311	ClC chloride channel EriC.  This domain is found in the EriC chloride transporters that mediate the extreme acid resistance response in eubacteria and archaea. This response allows bacteria to survive in the acidic environments by decarboxylation-linked...; Region: EriC; cd01031
195102004312	Cl- selectivity filter; other site
195102004313	Cl- binding residues [ion binding]; other site
195102004314	pore gating glutamate residue; other site
195102004315	dimer interface [polypeptide binding]; other site
195102004316	H+/Cl- coupling transport residue; other site
195102004317	TrkA-C domain; Region: TrkA_C; pfam02080
195102004318	electron transport complex, RnfABCDGE type, C subunit; Region: rnfC; TIGR01945
195102004319	SLBB domain; Region: SLBB; pfam10531
195102004320	The HCP family of iron-sulfur proteins includes hybrid cluster protein (HCP), acetyl-CoA synthase (ACS), and carbon monoxide dehydrogenase (CODH), all of which contain [Fe4-S4] metal clusters at their active sites. These proteins have a conserved...; Region: HCP_like; cl14655
195102004321	NQR2, RnfD, RnfE family; Region: NQR2_RnfD_RnfE; pfam03116
195102004322	Protein of unknown function (DUF1653); Region: DUF1653; pfam07866
195102004323	thiamine biosynthesis protein ThiI; Provisional; Region: PRK01565
195102004324	THUMP domain of thiamine biosynthesis protein ThiI; Region: THUMP_ThiI; cd11716
195102004325	ThiI is required for thiazole synthesis in the thiamine biosynthesis pathway. It belongs to the Adenosine Nucleotide Hydrolysis suoerfamily and predicted to bind to Adenosine nucleotide; Region: ThiI; cd01712
195102004326	Ligand Binding Site [chemical binding]; other site
195102004327	Cysteine sulfinate desulfinase/cysteine desulfurase and related enzymes [Amino acid transport and metabolism]; Region: NifS; COG1104
195102004328	cysteine desulfurase NifS; Region: FeS_nifS; TIGR03402
195102004329	pyridoxal 5'-phosphate binding pocket [chemical binding]; other site
195102004330	catalytic residue [active]
195102004331	hypothetical protein; Provisional; Region: PRK04435
195102004332	Helix-turn-helix domain of Hin and related proteins, a family of DNA-binding domains unique to bacteria and represented by the Hin protein of Salmonella. The basic HTH domain is a simple fold comprised of three core helices that form a right-handed...; Region: HTH_Hin_like; cl17393
195102004333	DNA-binding interface [nucleotide binding]; DNA binding site
195102004334	C-terminal ACT domain of a small (; 147 a.a.) putative phenylalanine biosynthetic pathway protein described in Bacillus subtilis (BS) PheB (PheB-BS) and related domains; Region: ACT_PheB-BS; cd04888
195102004335	alpha-mannosidase; Provisional; Region: PRK09819
195102004336	N-terminal catalytic domain of SPGH38, a putative alpha-mannosidase of Streptococcus pyogenes, and its prokaryotic homologs; glycoside hydrolase family 38 (GH38); Region: GH38N_AMII_SpGH38_like; cd10814
195102004337	active site
195102004338	metal binding site [ion binding]; metal-binding site
195102004339	homodimer interface [polypeptide binding]; other site
195102004340	catalytic site [active]
195102004341	Alpha mannosidase, middle domain; Region: Alpha-mann_mid; smart00872
195102004342	Acetyltransferase (GNAT) domain; Region: Acetyltransf_3; pfam13302
195102004343	Acetyltransferase (GNAT) family; Region: Acetyltransf_1; pfam00583
195102004344	Methionine synthase I (cobalamin-dependent), methyltransferase domain [Amino acid transport and metabolism]; Region: MetH; cl14105
195102004345	Homocysteine S-methyltransferase; Region: S-methyl_trans; pfam02574
195102004346	1-acyl-sn-glycerol-3-phosphate acyltransferase [Lipid metabolism]; Region: PlsC; COG0204
195102004347	Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: AGPAT-like; Region: LPLAT_AGPAT-like; cd07989
195102004348	putative acyl-acceptor binding pocket; other site
195102004349	Na+/alanine symporter [Amino acid transport and metabolism]; Region: AlsT; COG1115
195102004350	amino acid carrier protein; Region: agcS; TIGR00835
195102004351	Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077
195102004352	Zn2+ binding site [ion binding]; other site
195102004353	Mg2+ binding site [ion binding]; other site
195102004354	Predicted membrane protein [Function unknown]; Region: COG4684
195102004355	Protein of unknown function (DUF3816); Region: DUF3816; pfam12822
195102004356	nylC-like family; composed of proteins with similarity to Flavobacterium endo-type 6-aminohexanoate-oligomer hydrolase (EIII), the product of the nylon oligomer degradation gene, nylC. EIII is an amide hydrolase that catalyzes the degradation of...; Region: nylC_like; cd02252
195102004357	putative active site pocket [active]
195102004358	cleavage site
195102004359	Small, acid-soluble spore proteins, alpha/beta type; Region: SASP; pfam00269
195102004360	GGCT-like domains, also called AIG2-like family. Gamma-glutamyl cyclotransferase (GGCT) catalyzes the formation of pyroglutamic acid (5-oxoproline) from dipeptides containing gamma-glutamyl, and is a dimeric protein. In Homo sapiens, the protein is...; Region: GGCT_like; cd06661
195102004361	putative active site pocket [active]
195102004362	dimerization interface [polypeptide binding]; other site
195102004363	putative catalytic residue [active]
195102004364	Pyroglutamyl peptidase (PGP) type I, also known as pyrrolidone carboxyl peptidase (pcp) type I:  Enzymes responsible for cleaving pyroglutamate (pGlu) from the N-terminal end of specialized proteins. The N-terminal pGlu protects these proteins from...; Region: Peptidase_C15; cd00501
195102004365	putative substrate binding pocket [chemical binding]; other site
195102004366	AC domain interface; other site
195102004367	catalytic triad [active]
195102004368	AB domain interface; other site
195102004369	interchain disulfide; other site
195102004370	Predicted membrane protein [Function unknown]; Region: COG3817
195102004371	Protein of unknown function (DUF979); Region: DUF979; pfam06166
195102004372	Protein of unknown function (DUF969); Region: DUF969; pfam06149
195102004373	ATP-dependent chaperone ClpB; Region: chaperone_ClpB; TIGR03346
195102004374	Clp amino terminal domain; Region: Clp_N; pfam02861
195102004375	Clp amino terminal domain; Region: Clp_N; pfam02861
195102004376	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
195102004377	Walker A motif; other site
195102004378	ATP binding site [chemical binding]; other site
195102004379	Walker B motif; other site
195102004380	arginine finger; other site
195102004381	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
195102004382	Walker A motif; other site
195102004383	ATP binding site [chemical binding]; other site
195102004384	Walker B motif; other site
195102004385	C-terminal, D2-small domain, of ClpB protein; Region: ClpB_D2-small; pfam10431
195102004386	Nucleotidyltransferase (NT) domain of RelA- and SpoT-like ppGpp synthetases and hydrolases; Region: NT_Rel-Spo_like; cd05399
195102004387	synthetase active site [active]
195102004388	NTP binding site [chemical binding]; other site
195102004389	metal binding site [ion binding]; metal-binding site
195102004390	cardiolipin synthase; Region: bac_cardiolipin; TIGR04265
195102004391	Phospholipase_D-nuclease N-terminal; Region: PLDc_N; pfam13396
195102004392	Catalytic domain, repeat 1, of bacterial cardiolipin synthase and similar proteins; Region: PLDc_CLS_1; cd09110
195102004393	putative active site [active]
195102004394	catalytic site [active]
195102004395	catalytic domain repeat 2 of bacterial cardiolipin synthase and similar proteins; Region: PLDc_CLS_2; cd09112
195102004396	putative active site [active]
195102004397	catalytic site [active]
195102004398	L-aspartate oxidase; Region: nadB; TIGR00551
195102004399	L-aspartate oxidase; Provisional; Region: PRK06175
195102004400	Fumarate reductase flavoprotein C-term; Region: Succ_DH_flav_C; pfam02910
195102004401	glutamate-1-semialdehyde aminotransferase; Provisional; Region: PRK00062
195102004402	Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610
195102004403	inhibitor-cofactor binding pocket; inhibition site
195102004404	pyridoxal 5'-phosphate binding site [chemical binding]; other site
195102004405	catalytic residue [active]
195102004406	Porphobilinogen synthase (PBGS), which is also called delta-aminolevulinic acid dehydratase (ALAD), catalyzes the condensation of two 5-aminolevulinic acid (ALA) molecules to form the pyrrole porphobilinogen (PBG), which is the second step in the...; Region: ALAD_PBGS; cd00384
195102004407	dimer interface [polypeptide binding]; other site
195102004408	active site
195102004409	Schiff base residues; other site
195102004410	Uroporphyrin-III C-methyltransferase (S-Adenosyl-L-methionine:uroporphyrinogen III methyltransferase, SUMT); Region: SUMT; cd11642
195102004411	active site
195102004412	SAM binding site [chemical binding]; other site
195102004413	homodimer interface [polypeptide binding]; other site
195102004414	Uroporphyrinogen-III synthase [Coenzyme metabolism]; Region: HemD; COG1587
195102004415	Uroporphyrinogen-III synthase (HemD) catalyzes the asymmetrical cyclization of tetrapyrrole (linear) to uroporphyrinogen-III, the fourth step in the biosynthesis of heme. This ubiquitous enzyme is present in eukaryotes, bacteria and archaea. Mutations in...; Region: HemD; cd06578
195102004416	active site
195102004417	porphobilinogen deaminase; Reviewed; Region: hemC; PRK00072
195102004418	Hydroxymethylbilane synthase (HMBS), also known as porphobilinogen deaminase (PBGD), is an intermediate enzyme in the biosynthetic pathway of tetrapyrrolic ring systems, such as heme, chlorophylls, and vitamin B12. HMBS catalyzes the conversion of...; Region: HMBS; cd00494
195102004419	domain interfaces; other site
195102004420	active site
195102004421	precorrin-2 dehydrogenase; Provisional; Region: PRK05562
195102004422	Putative NAD(P)-binding; Region: NAD_binding_7; pfam13241
195102004423	glutamyl-tRNA reductase; Reviewed; Region: hemA; PRK00045
195102004424	NAD(P) binding domain of amino acid dehydrogenase-like proteins; Region: NAD_bind_amino_acid_DH; cl17226
195102004425	NAD(P) binding pocket [chemical binding]; other site
195102004426	Glutamyl-tRNAGlu reductase, dimerisation domain; Region: GlutR_dimer; pfam00745
195102004427	sulfite reductase, subunit C; Region: sulfite_red_C; TIGR02912
195102004428	Nitrite/Sulfite reductase ferredoxin-like half domain; Region: NIR_SIR_ferr; pfam03460
195102004429	The HCP family of iron-sulfur proteins includes hybrid cluster protein (HCP), acetyl-CoA synthase (ACS), and carbon monoxide dehydrogenase (CODH), all of which contain [Fe4-S4] metal clusters at their active sites. These proteins have a conserved...; Region: HCP_like; cl14655
195102004430	anaerobic sulfite reductase subunit B; Provisional; Region: PRK08221
195102004431	Anaerobic sulfite reductase contains an FAD and NADPH binding module with structural similarity to ferredoxin reductase and sequence similarity to dihydroorotate dehydrogenases. Clostridium pasteurianum inducible dissimilatory type sulfite reductase is...; Region: sulfite_reductase_like; cd06221
195102004432	FAD binding pocket [chemical binding]; other site
195102004433	FAD binding motif [chemical binding]; other site
195102004434	phosphate binding motif [ion binding]; other site
195102004435	beta-alpha-beta structure motif; other site
195102004436	NAD binding pocket [chemical binding]; other site
195102004437	Iron coordination center [ion binding]; other site
195102004438	anaerobic sulfite reductase subunit A; Provisional; Region: PRK15055
195102004439	cAMP-binding proteins - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases [Signal transduction mechanisms]; Region: Crp; COG0664
195102004440	effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038
195102004441	ligand binding site [chemical binding]; other site
195102004442	flexible hinge region; other site
195102004443	Crp-like helix-turn-helix domain; Region: HTH_Crp_2; pfam13545
195102004444	Formate/nitrite transporter; Region: Form_Nir_trans; pfam01226
195102004445	The GIY-YIG domain of uncharacterized protein family UPF0213 related to structure-specific endonuclease SLX1; Region: GIY-YIG_UPF0213; cd10456
195102004446	GIY-YIG motif/motif A; other site
195102004447	putative active site [active]
195102004448	putative metal binding site [ion binding]; other site
195102004449	Cupin domain; Region: Cupin_2; pfam07883
195102004450	helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342
195102004451	Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165
195102004452	Beta-xylosidase [Carbohydrate transport and metabolism]; Region: XynB; COG3664
195102004453	Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093
195102004454	non-specific DNA binding site [nucleotide binding]; other site
195102004455	salt bridge; other site
195102004456	sequence-specific DNA binding site [nucleotide binding]; other site
195102004457	Tetratricopeptide repeat; Region: TPR_12; pfam13424
195102004458	Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093
195102004459	non-specific DNA binding site [nucleotide binding]; other site
195102004460	salt bridge; other site
195102004461	sequence-specific DNA binding site [nucleotide binding]; other site
195102004462	Caulimovirus viroplasmin; Region: Cauli_VI; pfam01693
195102004463	Bacterial RNase HI containing a hybrid binding domain (HBD) at the N-terminus; Region: RNase_HI_bacteria_HBD; cd09277
195102004464	RNA/DNA hybrid binding site [nucleotide binding]; other site
195102004465	active site
195102004466	Uncharacterized conserved protein [Function unknown]; Region: COG3339
195102004467	Rhomboid family; Region: Rhomboid; pfam01694
195102004468	oligoendopeptidase F; Region: pepF; TIGR00181
195102004469	Peptidase family M3B Oligopeptidase F (PepF); Region: M3B_PepF_3; cd09608
195102004470	active site
195102004471	Zn binding site [ion binding]; other site
195102004472	ABC-type cobalt transport system, ATPase component [Inorganic ion transport and metabolism]; Region: CbiO; COG1122
195102004473	ATP-binding cassette domain of the metal-type transporters; Region: ABC_Metallic_Cations; cd03235
195102004474	ABC-type Mn2+/Zn2+ transport systems, permease components [Inorganic ion transport and metabolism]; Region: ZnuB; COG1108
195102004475	Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550
195102004476	ABC-ATPase subunit  interface; other site
195102004477	dimer interface [polypeptide binding]; other site
195102004478	putative PBP binding regions; other site
195102004479	Na+-driven multidrug efflux pump [Defense mechanisms]; Region: NorM; COG0534
195102004480	Uncharacterized subfamily of the multidrug and toxic compound extrusion (MATE) proteins; Region: MATE_like_1; cd13140
195102004481	Fn3 associated; Region: Fn3_assoc; pfam13287
195102004482	F5/8 type C domain; Region: F5_F8_type_C; pfam00754
195102004483	ferric uptake regulator; Provisional; Region: fur; PRK09462
195102004484	Ferric uptake regulator(Fur) and related metalloregulatory proteins; typically iron-dependent, DNA-binding repressors and activators; Region: Fur_like; cd07153
195102004485	metal binding site 2 [ion binding]; metal-binding site
195102004486	putative DNA binding helix; other site
195102004487	metal binding site 1 [ion binding]; metal-binding site
195102004488	dimer interface [polypeptide binding]; other site
195102004489	structural Zn2+ binding site [ion binding]; other site
195102004490	Phosphotransferase system, mannose/fructose/N-acetylgalactosamine-specific component IID [Carbohydrate transport and metabolism]; Region: ManZ; COG3716
195102004491	Phosphotransferase system, mannose/fructose/N-acetylgalactosamine-specific component IIC [Carbohydrate transport and metabolism]; Region: ManY; COG3715
195102004492	PTS system sorbose subfamily IIB component; Region: PTSIIB_sorb; pfam03830
195102004493	active site
195102004494	phosphorylation site [posttranslational modification]
195102004495	PTS_IIA, PTS system, mannose/sorbose specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIA_man; cd00006
195102004496	active pocket/dimerization site; other site
195102004497	active site
195102004498	phosphorylation site [posttranslational modification]
195102004499	6-phosphofructokinase; Provisional; Region: PRK14072
195102004500	6-phosphofructokinase; Region: PFKA_ATP; TIGR02482
195102004501	active site
195102004502	ADP/pyrophosphate binding site [chemical binding]; other site
195102004503	dimerization interface [polypeptide binding]; other site
195102004504	allosteric effector site; other site
195102004505	fructose-1,6-bisphosphate binding site; other site
195102004506	C_GCAxxG_C_C family probable redox protein; Region: C_GCAxxG_C_C; TIGR01909
195102004507	Selenocysteine lyase/Cysteine desulfurase [Posttranslational modification, protein turnover, chaperones]; Region: csdA; COG0520
195102004508	Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321
195102004509	pyridoxal 5'-phosphate binding pocket [chemical binding]; other site
195102004510	catalytic residue [active]
195102004511	ATPase components of ABC transporters with duplicated ATPase domains [General function prediction only]; Region: Uup; COG0488
195102004512	ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221
195102004513	ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221
195102004514	ABC transporter; Region: ABC_tran_2; pfam12848
195102004515	ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221
195102004516	Trimeric dUTP diphosphatases; Region: trimeric_dUTPase; cd07557
195102004517	trimer interface [polypeptide binding]; other site
195102004518	active site
195102004519	Domain of unknown function (DUF1836); Region: DUF1836; pfam08876
195102004520	channel protein, hemolysin III family; Region: hlyIII; TIGR01065
195102004521	Predicted membrane protein, hemolysin III homolog [General function prediction only]; Region: COG1272
195102004522	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
195102004523	putative DNA-binding transcriptional regulator; Provisional; Region: PRK10837
195102004524	C-terminal substrate binding domain of LysR-type transcriptional regulator CysL, which activates the transcription of the cysJI operon encoding sulfite reductase, contains the type 2 periplasmic binding fold; Region: PBP2_CysL_like; cd08420
195102004525	putative dimerization interface [polypeptide binding]; other site
195102004526	Predicted xylanase/chitin deacetylase [Carbohydrate transport and metabolism]; Region: CDA1; COG0726
195102004527	Catalytic NodB homology domain of Streptococcus mutans polysaccharide deacetylase PgdA, Bacillus subtilis YheN, and similar proteins; Region: CE4_SmPgdA_like; cd10944
195102004528	NodB motif; other site
195102004529	active site
195102004530	catalytic site [active]
195102004531	Zn binding site [ion binding]; other site
195102004532	N-acetylmuramoyl-L-alanine amidase or MurNAc-LAA (also known as peptidoglycan aminohydrolase, NAMLA amidase, NAMLAA, Amidase 3, and peptidoglycan amidase; EC 3.5.1.28) is an autolysin that hydrolyzes the amide bond between N-acetylmuramoyl and L-amino...; Region: MurNAc-LAA; cl02713
195102004533	putative transporter; Provisional; Region: PRK11660
195102004534	Sulfate transporter N-terminal domain with GLY motif; Region: Sulfate_tra_GLY; pfam13792
195102004535	Sulfate transporter family; Region: Sulfate_transp; pfam00916
195102004536	Sulphate Transporter and Anti-Sigma factor antagonist domain of SulP-like sulfate transporters, plays a role in the function and regulation of the transport activity, proposed general NTP binding function; Region: STAS_SulP_like_sulfate_transporter; cd07042
195102004537	YeiC-like sugar kinase.  Found in eukaryotes and bacteria, YeiC-like kinase is part of the ribokinase/pfkB sugar kinase superfamily. Its oligomerization state is unknown at this time; Region: YeiC_kinase_like; cd01941
195102004538	Sugar kinases, ribokinase family [Carbohydrate transport and metabolism]; Region: RbsK; COG0524
195102004539	substrate binding site [chemical binding]; other site
195102004540	ATP binding site [chemical binding]; other site
195102004541	Domain of unknown function (DUF4250); Region: DUF4250; pfam14056
195102004542	Na+-driven multidrug efflux pump [Defense mechanisms]; Region: NorM; COG0534
195102004543	Subfamily of the multidrug and toxic compound extrusion (MATE)-like proteins similar to Streptococcus aureus MepA; Region: MATE_MepA_like; cd13143
195102004544	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
195102004545	ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136
195102004546	Walker A/P-loop; other site
195102004547	ATP binding site [chemical binding]; other site
195102004548	Q-loop/lid; other site
195102004549	ABC transporter signature motif; other site
195102004550	Walker B; other site
195102004551	D-loop; other site
195102004552	H-loop/switch region; other site
195102004553	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
195102004554	dimer interface [polypeptide binding]; other site
195102004555	conserved gate region; other site
195102004556	putative PBP binding loops; other site
195102004557	ABC-ATPase subunit interface; other site
195102004558	Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of  substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cl17432
195102004559	NMT1/THI5 like; Region: NMT1; pfam09084
195102004560	Sulfite exporter TauE/SafE; Region: TauE; pfam01925
195102004561	Uncharacterized membrane-associated protein [Function unknown]; Region: DedA; COG0586
195102004562	SNARE associated Golgi protein; Region: SNARE_assoc; cl00429
195102004563	Uncharacterized membrane-associated protein [Function unknown]; Region: DedA; COG0586
195102004564	SNARE associated Golgi protein; Region: SNARE_assoc; pfam09335
195102004565	This is a subfamily of Adenine nucleotide alpha hydrolases superfamily.Adeninosine nucleotide alpha hydrolases superfamily  includes N type ATP PPases and ATP sulphurylases. It forms a apha/beta/apha fold which  binds to Adenosine group.  This subfamily; Region: Alpha_ANH_like_II; cd01993
195102004566	ACT domain proteins similar to the yet uncharacterized Streptococcus pneumoniae ACT domain protein; Region: ACT_1ZPV; cd04872
195102004567	Uncharacterized proteins with similarity to Ribonucleotide reductase and Pyruvate formate lyase; Region: RNR_PFL_like_DUF711; cd08025
195102004568	QueT transporter; Region: QueT; pfam06177
195102004569	Predicted hydrolase (metallo-beta-lactamase superfamily) [General function prediction only]; Region: ComEC; COG2333
195102004570	Metallo-beta-lactamase superfamily; Region: Lactamase_B; pfam00753
195102004571	Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase; Region: HATPase_c; pfam02518
195102004572	ATP binding site [chemical binding]; other site
195102004573	Mg2+ binding site [ion binding]; other site
195102004574	G-X-G motif; other site
195102004575	Response regulator of the LytR/AlgR family [Transcription / Signal transduction mechanisms]; Region: LytT; COG3279
195102004576	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
195102004577	active site
195102004578	phosphorylation site [posttranslational modification]
195102004579	intermolecular recognition site; other site
195102004580	dimerization interface [polypeptide binding]; other site
195102004581	LytTr DNA-binding domain; Region: LytTR; pfam04397
195102004582	N-acetylmuramoyl-L-alanine amidase [Cell envelope biogenesis, outer membrane]; Region: AmiC; COG0860
195102004583	N-acetylmuramoyl-L-alanine amidase or MurNAc-LAA (also known as peptidoglycan aminohydrolase, NAMLA amidase, NAMLAA, Amidase 3, and peptidoglycan amidase; EC 3.5.1.28) is an autolysin that hydrolyzes the amide bond between N-acetylmuramoyl and L-amino...; Region: MurNAc-LAA; cd02696
195102004584	active site
195102004585	metal binding site [ion binding]; metal-binding site
195102004586	Domain of unknown function DUF77; Region: DUF77; pfam01910
195102004587	Domain of unknown function (DUF348); Region: DUF348; pfam03990
195102004588	Domain of unknown function (DUF348); Region: DUF348; pfam03990
195102004589	G5 domain; Region: G5; pfam07501
195102004590	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3584
195102004591	uracil transporter; Provisional; Region: PRK10720
195102004592	ABC transporter ATP-binding protein; Provisional; Region: PRK15064
195102004593	ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221
195102004594	ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221
195102004595	ABC transporter; Region: ABC_tran_2; pfam12848
195102004596	ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221
195102004597	Predicted xylanase/chitin deacetylase [Carbohydrate transport and metabolism]; Region: CDA1; COG0726
195102004598	Catalytic NodB homology domain of Streptococcus mutans polysaccharide deacetylase PgdA, Bacillus subtilis YheN, and similar proteins; Region: CE4_SmPgdA_like; cd10944
195102004599	NodB motif; other site
195102004600	active site
195102004601	catalytic site [active]
195102004602	Zn binding site [ion binding]; other site
195102004603	DNA topoisomerase III; Provisional; Region: PRK07726
195102004604	TOPRIM_TopoIA_TopoIII: The topoisomerase-primase (TORPIM) domain found in members of the type IA family of DNA topoisomerases (Topo IA) similar to topoisomerase III. Type IA DNA topoisomerases remove (relax) negative supercoils in the DNA by: cleaving...; Region: TOPRIM_TopoIA_TopoIII; cd03362
195102004605	active site
195102004606	putative interdomain interaction site [polypeptide binding]; other site
195102004607	putative metal-binding site [ion binding]; other site
195102004608	putative nucleotide binding site [chemical binding]; other site
195102004609	DNA Topoisomerase, subtype IA; DNA-binding, ATP-binding and catalytic domain of bacterial DNA topoisomerases I and III, and eukaryotic DNA topoisomerase III and eubacterial and archael reverse gyrases. Topoisomerases clevage single or double stranded DNA...; Region: TOP1Ac; cd00186
195102004610	domain I; other site
195102004611	DNA binding groove [nucleotide binding]
195102004612	phosphate binding site [ion binding]; other site
195102004613	domain II; other site
195102004614	domain III; other site
195102004615	nucleotide binding site [chemical binding]; other site
195102004616	catalytic site [active]
195102004617	domain IV; other site
195102004618	Zn-finger domain associated with topoisomerase type I [DNA replication, recombination, and repair]; Region: TopA; COG0551
195102004619	Predicted membrane protein [Function unknown]; Region: COG3428
195102004620	Bacterial PH domain; Region: DUF304; pfam03703
195102004621	Bacterial PH domain; Region: DUF304; pfam03703
195102004622	Bacterial PH domain; Region: DUF304; pfam03703
195102004623	Predicted periplasmic ligand-binding sensor domain [Signal transduction mechanisms]; Region: COG3292
195102004624	Two component regulator propeller; Region: Reg_prop; pfam07494
195102004625	Y_Y_Y domain; Region: Y_Y_Y; pfam07495
195102004626	Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642
195102004627	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
195102004628	dimer interface [polypeptide binding]; other site
195102004629	phosphorylation site [posttranslational modification]
195102004630	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
195102004631	ATP binding site [chemical binding]; other site
195102004632	Mg2+ binding site [ion binding]; other site
195102004633	G-X-G motif; other site
195102004634	DHHW protein; Region: DHHW; pfam14286
195102004635	DHHW protein; Region: DHHW; pfam14286
195102004636	Predicted membrane protein involved in D-alanine export [Cell envelope biogenesis, outer membrane]; Region: DltB; COG1696
195102004637	Domain of unknown function (DUF4358); Region: DUF4358; pfam14270
195102004638	Superfamily II DNA and RNA helicases [DNA replication, recombination, and repair / Transcription / Translation, ribosomal structure and biogenesis]; Region: SrmB; COG0513
195102004639	DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cl17251
195102004640	ATP binding site [chemical binding]; other site
195102004641	putative Mg++ binding site [ion binding]; other site
195102004642	Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079
195102004643	nucleotide binding region [chemical binding]; other site
195102004644	ATP-binding site [chemical binding]; other site
195102004645	glutamate dehydrogenase; Provisional; Region: PRK09414
195102004646	Glu/Leu/Phe/Val dehydrogenase, dimerisation domain; Region: ELFV_dehydrog_N; pfam02812
195102004647	NAD(P) binding domain of glutamate dehydrogenase, subgroup 2; Region: NAD_bind_2_Glu_DH; cd05313
195102004648	NAD(P) binding site [chemical binding]; other site
195102004649	branched-chain amino acid aminotransferase; Provisional; Region: PRK13357
195102004650	BCAT_beta_family: Branched-chain aminotransferase catalyses the transamination of the branched-chain amino acids  leusine, isoleucine and valine to their respective alpha-keto acids, alpha-ketoisocaproate, alpha-keto-beta-methylvalerate and...; Region: BCAT_beta_family; cd01557
195102004651	homodimer interface [polypeptide binding]; other site
195102004652	substrate-cofactor binding pocket; other site
195102004653	catalytic residue [active]
195102004654	Glycosyl hydrolase family 67 N-terminus; Region: Glyco_hydro_67N; pfam03648
195102004655	beta-N-acetylglucosaminidase; Region: NAGidase; pfam07555
195102004656	F5/8 type C domain; Region: F5_F8_type_C; pfam00754
195102004657	sugar binding site [chemical binding]; other site
195102004658	Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all...; Region: FN3; cd00063
195102004659	Interdomain contacts; other site
195102004660	Cytokine receptor motif; other site
195102004661	Protein tyrosine phosphatases (PTP) catalyze the dephosphorylation of phosphotyrosine peptides; they regulate phosphotyrosine levels in signal transduction pathways. The depth of the active site cleft renders the enzyme specific for phosphorylated Tyr; Region: PTPc; cl00053
195102004662	ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132
195102004663	ABC transporter transmembrane region; Region: ABC_membrane; pfam00664
195102004664	ATP-binding cassette domain of the bacterial lipid flippase and related proteins, subfamily C; Region: ABCC_MsbA; cd03251
195102004665	Walker A/P-loop; other site
195102004666	ATP binding site [chemical binding]; other site
195102004667	Q-loop/lid; other site
195102004668	ABC transporter signature motif; other site
195102004669	Walker B; other site
195102004670	D-loop; other site
195102004671	H-loop/switch region; other site
195102004672	ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132
195102004673	ABC transporter transmembrane region; Region: ABC_membrane; pfam00664
195102004674	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
195102004675	Walker A/P-loop; other site
195102004676	ATP binding site [chemical binding]; other site
195102004677	Q-loop/lid; other site
195102004678	ABC transporter signature motif; other site
195102004679	Walker B; other site
195102004680	D-loop; other site
195102004681	H-loop/switch region; other site
195102004682	Putative NodB-like catalytic domain of uncharacterized proteins found in bacteria; Region: CE4_COG5298; cd10923
195102004683	Uncharacterized protein conserved in bacteria (DUF2334); Region: DUF2334; pfam10096
195102004684	NodB motif; other site
195102004685	putative active site [active]
195102004686	putative catalytic site [active]
195102004687	putative Zn binding site [ion binding]; other site
195102004688	Sugar kinases, ribokinase family [Carbohydrate transport and metabolism]; Region: RbsK; COG0524
195102004689	Fructokinases (FRKs) mainly from bacteria and plants are enzymes with high specificity for fructose, as are all FRKs, but they catalyzes the conversion of fructose to fructose-6-phosphate, which is an entry point into glycolysis via conversion into...; Region: bac_FRK; cd01167
195102004690	putative substrate binding site [chemical binding]; other site
195102004691	putative ATP binding site [chemical binding]; other site
195102004692	sucrose-6-phosphate hydrolase; Region: scrB_fam; TIGR01322
195102004693	Glycosyl hydrolase family 32, beta-fructosidases; Region: GH32_B_Fructosidase; cd08996
195102004694	substrate binding [chemical binding]; other site
195102004695	active site
195102004696	Glycosyl hydrolases family 32 C terminal; Region: Glyco_hydro_32C; pfam08244
195102004697	Transcriptional regulators [Transcription]; Region: PurR; COG1609
195102004698	Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392
195102004699	DNA binding site [nucleotide binding]
195102004700	domain linker motif; other site
195102004701	Ligand-binding domain of DNA transcription repressor specific for trehalose (TreR) which is a member of the LacI-GalR family of bacterial transcription regulators; Region: PBP1_TreR_like; cd01542
195102004702	dimerization interface [polypeptide binding]; other site
195102004703	ligand binding site [chemical binding]; other site
195102004704	PTS system, sucrose-specific IIBC component; Region: PTS-II-BC-sucr; TIGR01996
195102004705	PTS_IIB, PTS system, glucose/sucrose specific IIB subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIB_glc; cd00212
195102004706	active site turn [active]
195102004707	phosphorylation site [posttranslational modification]
195102004708	Phosphotransferase system IIC components, glucose/maltose/N-acetylglucosamine-specific [Carbohydrate transport and metabolism]; Region: PtsG; COG1263
195102004709	Alpha/beta hydrolase family; Region: Abhydrolase_5; pfam12695
195102004710	sulfite reductase, subunit C; Region: sulfite_red_C; TIGR02912
195102004711	Nitrite/Sulfite reductase ferredoxin-like half domain; Region: NIR_SIR_ferr; pfam03460
195102004712	RPB11 and RPB3 subunits of RNA polymerase; Region: RNAP_RPB11_RPB3; cl11409
195102004713	anaerobic sulfite reductase subunit B; Provisional; Region: PRK08221
195102004714	Anaerobic sulfite reductase contains an FAD and NADPH binding module with structural similarity to ferredoxin reductase and sequence similarity to dihydroorotate dehydrogenases. Clostridium pasteurianum inducible dissimilatory type sulfite reductase is...; Region: sulfite_reductase_like; cd06221
195102004715	FAD binding pocket [chemical binding]; other site
195102004716	FAD binding motif [chemical binding]; other site
195102004717	phosphate binding motif [ion binding]; other site
195102004718	beta-alpha-beta structure motif; other site
195102004719	NAD binding pocket [chemical binding]; other site
195102004720	Iron coordination center [ion binding]; other site
195102004721	anaerobic sulfite reductase subunit A; Provisional; Region: PRK15055
195102004722	The HCP family of iron-sulfur proteins includes hybrid cluster protein (HCP), acetyl-CoA synthase (ACS), and carbon monoxide dehydrogenase (CODH), all of which contain [Fe4-S4] metal clusters at their active sites. These proteins have a conserved...; Region: HCP_like; cl14655
195102004723	MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704
195102004724	ABC-type antimicrobial peptide transport system, permease component [Defense mechanisms]; Region: SalY; COG0577
195102004725	FtsX-like permease family; Region: FtsX; pfam02687
195102004726	ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136
195102004727	ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255
195102004728	Walker A/P-loop; other site
195102004729	ATP binding site [chemical binding]; other site
195102004730	Q-loop/lid; other site
195102004731	ABC transporter signature motif; other site
195102004732	Walker B; other site
195102004733	D-loop; other site
195102004734	H-loop/switch region; other site
195102004735	Membrane-fusion protein [Cell envelope biogenesis, outer membrane]; Region: AcrA; COG0845
195102004736	HlyD family secretion protein; Region: HlyD_3; pfam13437
195102004737	AAA domain; Region: AAA_26; pfam13500
195102004738	dithiobiotin synthetase; Reviewed; Region: bioD; PRK00090
195102004739	biotin synthase; Region: bioB; TIGR00433
195102004740	Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335
195102004741	FeS/SAM binding site; other site
195102004742	Biotin and Thiamin Synthesis associated domain; Region: BATS; pfam06968
195102004743	Uncharacterized conserved protein [General function prediction only]; Region: BioY; COG1268
195102004744	Predicted secreted protein [Function unknown]; Region: COG4086
195102004745	Protein of unknown function (DUF1002); Region: DUF1002; pfam06207
195102004746	stage V sporulation protein K; Region: spore_V_K; TIGR02881
195102004747	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
195102004748	Walker B motif; other site
195102004749	arginine finger; other site
195102004750	stage V sporulation protein K; Region: spore_V_K; TIGR02881
195102004751	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
195102004752	Walker A motif; other site
195102004753	ATP binding site [chemical binding]; other site
195102004754	Walker B motif; other site
195102004755	arginine finger; other site
195102004756	stage V sporulation protein K; Region: spore_V_K; TIGR02881
195102004757	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cl17189
195102004758	Walker A motif; other site
195102004759	ATP binding site [chemical binding]; other site
195102004760	Walker B motif; other site
195102004761	arginine finger; other site
195102004762	Anaerobic dehydrogenases, typically selenocysteine-containing [Energy production and conversion]; Region: BisC; COG0243
195102004763	The MopB_3 CD includes a group of related uncharacterized bacterial and archaeal molybdopterin-binding oxidoreductase-like domains with a putative N-terminal iron-sulfur [4Fe-4S] cluster binding site and molybdopterin cofactor binding site. These members...; Region: MopB_3; cd02766
195102004764	putative [4Fe-4S] binding site [ion binding]; other site
195102004765	putative molybdopterin cofactor binding site [chemical binding]; other site
195102004766	Molybdopterin-Binding, C-terminal (MopB_CT) domain of the MopB superfamily of proteins, a  large, diverse, heterogeneous superfamily of enzymes that, in general, bind molybdopterin as a cofactor. The MopB domain is found in a wide variety of molybdenum-...; Region: MopB_CT; cd02775
195102004767	phosphoribosylpyrophosphate synthetase; Provisional; Region: PRK06827
195102004768	N-terminal domain of ribose phosphate pyrophosphokinase; Region: Pribosyltran_N; pfam13793
195102004769	Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223
195102004770	active site
195102004771	hypothetical protein; Provisional; Region: PRK06851
195102004772	AAA domain; Region: AAA_30; pfam13604
195102004773	Predicted xylanase/chitin deacetylase [Carbohydrate transport and metabolism]; Region: CDA1; COG0726
195102004774	Catalytic NodB homology domain of Streptococcus mutans polysaccharide deacetylase PgdA, Bacillus subtilis YheN, and similar proteins; Region: CE4_SmPgdA_like; cd10944
195102004775	NodB motif; other site
195102004776	active site
195102004777	catalytic site [active]
195102004778	Zn binding site [ion binding]; other site
195102004779	pullulanase, type I; Region: pulA_typeI; TIGR02104
195102004780	Early set domain associated with the catalytic domain of pullulanase (also called dextrinase and alpha-dextrin endo-1,6-alpha glucosidase); Region: E_set_Pullulanase; cd02860
195102004781	Alpha amylase catalytic domain found in Pullulanase (also called dextrinase; alpha-dextrin endo-1,6-alpha glucosidase), limit dextrinase, and related proteins; Region: AmyAc_Pullulanase_LD-like; cd11341
195102004782	Ca binding site [ion binding]; other site
195102004783	active site
195102004784	catalytic site [active]
195102004785	Domain of unknown function (DUF3372); Region: DUF3372; pfam11852
195102004786	signal peptidase I, bacterial type; Region: sigpep_I_bact; TIGR02227
195102004787	The S26 Type I signal peptidase (SPase; LepB; leader peptidase B; leader peptidase I; EC 3.4.21.89) family members are essential membrane-bound serine proteases that function to cleave the amino-terminal signal peptide extension from proteins that are...; Region: S26_SPase_I; cd06530
195102004788	Catalytic site [active]
195102004789	ATP cone domain; Region: ATP-cone; pfam03477
195102004790	Sulfatase; Region: Sulfatase; pfam00884
195102004791	Predicted membrane protein [Function unknown]; Region: COG4129
195102004792	Bacterial protein of unknown function (DUF939); Region: DUF939; pfam06081
195102004793	DUF939 C-terminal domain; Region: DUF939_C; pfam11728
195102004794	Undecaprenyl pyrophosphate synthase [Lipid metabolism]; Region: UppS; COG0020
195102004795	Cis (Z)-Isoprenyl Diphosphate Synthases (cis-IPPS); homodimers which catalyze the successive 1'-4 condensation of the isopentenyl diphosphate (IPP) molecule to trans,trans-farnesyl diphosphate (FPP) or to cis,trans-FPP to form long-chain polyprenyl...; Region: CIS_IPPS; cl00230
195102004796	catalytic residue [active]
195102004797	putative FPP diphosphate  binding site; other site
195102004798	putative FPP binding hydrophobic cleft; other site
195102004799	dimer interface [polypeptide binding]; other site
195102004800	putative IPP diphosphate binding site; other site
195102004801	phytoene desaturase; Region: crtI_fam; TIGR02734
195102004802	NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450
195102004803	c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal    transduction mechanisms]; Region: COG2199
195102004804	Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949
195102004805	metal binding site [ion binding]; metal-binding site
195102004806	active site
195102004807	I-site; other site
195102004808	c-di-GMP phosphodiesterase class II (HD-GYP domain) [Signal transduction mechanisms]; Region: COG2206
195102004809	Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077
195102004810	Zn2+ binding site [ion binding]; other site
195102004811	Mg2+ binding site [ion binding]; other site
195102004812	Accessory gene regulator B; Region: AgrB; smart00793
195102004813	Uncharacterized conserved protein [Function unknown]; Region: COG0398
195102004814	SNARE associated Golgi protein; Region: SNARE_assoc; pfam09335
195102004815	Ca2+/Na+ antiporter [Inorganic ion transport and metabolism]; Region: ECM27; COG0530
195102004816	Sodium/calcium exchanger protein; Region: Na_Ca_ex; pfam01699
195102004817	Sodium/calcium exchanger protein; Region: Na_Ca_ex; pfam01699
195102004818	DNA Polymerase IV/Kappa; Region: PolY_Pol_IV_kappa; cd03586
195102004819	active site
195102004820	DNA polymerase IV; Validated; Region: PRK02406
195102004821	DNA binding site [nucleotide binding]
195102004822	cyclophilin: cyclophilin-type peptidylprolyl cis- trans isomerases. This family contains eukaryotic, bacterial and archeal proteins which exhibit a peptidylprolyl cis- trans isomerases activity (PPIase, Rotamase) and in addition bind the...; Region: cyclophilin; cd00317
195102004823	active site
195102004824	Protein of unknown function (DUF3785); Region: DUF3785; pfam12653
195102004825	Predicted hydrolases of the HAD superfamily [General function prediction only]; Region: Cof; COG0561
195102004826	Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427
195102004827	active site
195102004828	motif I; other site
195102004829	motif II; other site
195102004830	Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427
195102004831	Phage shock protein A (IM30), suppresses sigma54-dependent transcription [Transcription / Signal transduction mechanisms]; Region: PspA; COG1842
195102004832	bifunctional glutamate--cysteine ligase/glutathione synthetase; Provisional; Region: PRK02471
195102004833	Glutamate-cysteine ligase; Region: Glu_cys_ligase; cl17352
195102004834	ATP-grasp domain; Region: ATP-grasp_4; cl17255
195102004835	Hypothetical patatin similar to Z1214 protein of Escherichia coli; Region: Pat_hypo_Ecoli_Z1214_like; cd07209
195102004836	Predicted esterase of the alpha-beta hydrolase superfamily [General function prediction only]; Region: RssA; COG1752
195102004837	nucleophile elbow; other site
195102004838	Xanthine/uracil/vitamin C permease [Nucleotide transport and    metabolism]; Region: COG2252
195102004839	CoA binding domain; Region: CoA_binding_2; pfam13380
195102004840	Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653
195102004841	Transmembrane subunit (TM) of Treponema pallidum (Tp) RbsC-1, RbsC-2 and related proteins. This is a functionally uncharacterized subgroup of TMs which belong to a larger group of TMs of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette; Region: TM_PBP1_transp_TpRbsC_like; cd06580
195102004842	TM-ABC transporter signature motif; other site
195102004843	Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653
195102004844	Transmembrane subunit (TM) of Treponema pallidum (Tp) RbsC-1, RbsC-2 and related proteins. This is a functionally uncharacterized subgroup of TMs which belong to a larger group of TMs of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette; Region: TM_PBP1_transp_TpRbsC_like; cd06580
195102004845	TM-ABC transporter signature motif; other site
195102004846	ABC-type uncharacterized transport systems, ATPase components [General function prediction only]; Region: COG3845
195102004847	First domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_I; cd03216
195102004848	Walker A/P-loop; other site
195102004849	ATP binding site [chemical binding]; other site
195102004850	Q-loop/lid; other site
195102004851	ABC transporter signature motif; other site
195102004852	Walker B; other site
195102004853	D-loop; other site
195102004854	H-loop/switch region; other site
195102004855	Second domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_II; cd03215
195102004856	Uncharacterized ABC-type transport system, periplasmic component/surface lipoprotein [General function prediction only]; Region: Med; COG1744
195102004857	Periplasmic binding domain of basic membrane lipoprotein, PnrA, in Treponema pallidum and its homologs from other bacteria and Archaea; Region: PBP1_BmpA_PnrA_like; cd06354
195102004858	ligand binding site [chemical binding]; other site
195102004859	Alpha/beta hydrolase family; Region: Abhydrolase_5; pfam12695
195102004860	ABC-type cobalt transport system, permease component CbiQ and related transporters [Inorganic ion transport and metabolism]; Region: CbiQ; COG0619
195102004861	ABC-type cobalt transport system, ATPase component [Inorganic ion transport and metabolism]; Region: CbiO; COG1122
195102004862	First domain of the ATP-binding cassette component of cobalt transport system; Region: ABC_cobalt_CbiO_domain1; cd03225
195102004863	Walker A/P-loop; other site
195102004864	ATP binding site [chemical binding]; other site
195102004865	Q-loop/lid; other site
195102004866	ABC transporter signature motif; other site
195102004867	Walker B; other site
195102004868	D-loop; other site
195102004869	H-loop/switch region; other site
195102004870	ATP-binding cassette cobalt transporter; Region: DUF3744; pfam12558
195102004871	ABC-type cobalt transport system, ATPase component [Inorganic ion transport and metabolism]; Region: CbiO; COG1122
195102004872	First domain of the ATP-binding cassette component of cobalt transport system; Region: ABC_cobalt_CbiO_domain1; cd03225
195102004873	Walker A/P-loop; other site
195102004874	ATP binding site [chemical binding]; other site
195102004875	Q-loop/lid; other site
195102004876	ABC transporter signature motif; other site
195102004877	Walker B; other site
195102004878	D-loop; other site
195102004879	H-loop/switch region; other site
195102004880	hypothetical protein; Provisional; Region: PRK13661
195102004881	Rhodanese Homology Domain (RHOD); an alpha beta fold domain found duplicated in the rhodanese protein. The cysteine containing enzymatically active version of the domain is also found in the Cdc25 class of protein phosphatases and a variety of proteins...; Region: RHOD; cd00158
195102004882	active site residue [active]
195102004883	Early set domain associated with the catalytic domain of sugar utilizing enzymes at either the N or C terminus; Region: E_set; cl09101
195102004884	Early set domain associated with the catalytic domain of pullulanase (also called dextrinase and alpha-dextrin endo-1,6-alpha glucosidase); Region: E_set_Pullulanase; cd02860
195102004885	pullulanase, type I; Region: pulA_typeI; TIGR02104
195102004886	Alpha amylase catalytic domain found in Pullulanase (also called dextrinase; alpha-dextrin endo-1,6-alpha glucosidase), limit dextrinase, and related proteins; Region: AmyAc_Pullulanase_LD-like; cd11341
195102004887	Ca binding site [ion binding]; other site
195102004888	active site
195102004889	catalytic site [active]
195102004890	glycogen branching enzyme; Provisional; Region: PRK12313
195102004891	N-terminal Early set domain associated with the catalytic domain of prokaryotic glycogen branching enzyme; Region: E_set_GBE_prok_N; cd02855
195102004892	Alpha amylase catalytic domain found in the Glycogen branching enzyme (also called 1,4-alpha-glucan branching enzyme); Region: AmyAc_Glg_BE; cd11322
195102004893	active site
195102004894	catalytic site [active]
195102004895	Alpha amylase, C-terminal all-beta domain; Region: Alpha-amylase_C; pfam02806
195102004896	Uncharacterized conserved protein [Function unknown]; Region: COG2966
195102004897	Protein of unknown function (DUF1212); Region: DUF1212; pfam06738
195102004898	Protein of unknown function (DUF3815); Region: DUF3815; pfam12821
195102004899	Uncharacterized conserved protein [Function unknown]; Region: COG2898
195102004900	Uncharacterized conserved protein (DUF2156); Region: DUF2156; pfam09924
195102004901	TRX family; composed of two groups: Group I, which includes proteins that exclusively encode a TRX domain; and Group II, which are composed of fusion proteins of TRX and additional domains. Group I TRX is a small ancient protein that alter the redox...; Region: TRX_family; cd02947
195102004902	catalytic residues [active]
195102004903	Acetyl xylan esterase (AXE1); Region: AXE1; pfam05448
195102004904	Predicted hydrolase (metallo-beta-lactamase superfamily) [General function prediction only]; Region: ComEC; COG2333
195102004905	Metallo-beta-lactamase superfamily; Region: Lactamase_B; pfam00753
195102004906	Domain of unknown function (DUF3783); Region: DUF3783; pfam12646
195102004907	Thiamine monophosphate synthase (TMP synthase)/TenI. TMP synthase catalyzes an important step in the thiamine biosynthesis pathway, the substitution of the pyrophosphate of 2-methyl-4-amino-5- hydroxymethylpyrimidine pyrophosphate by 4-methyl-5-; Region: TMP_TenI; cd00564
195102004908	thiamine phosphate binding site [chemical binding]; other site
195102004909	active site
195102004910	pyrophosphate binding site [ion binding]; other site
195102004911	thiamine biosynthesis protein ThiH; Reviewed; Region: thiH; PRK09240
195102004912	Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335
195102004913	FeS/SAM binding site; other site
195102004914	Biotin and Thiamin Synthesis associated domain; Region: BATS; pfam06968
195102004915	Thiazole synthase (ThiG) is the tetrameric enzyme that is involved in the formation of the thiazole moiety of thiamin pyrophosphate, an essential ubiquitous cofactor that plays an important role in carbohydrate and amino acid metabolism. ThiG catalyzes...; Region: ThiG; cd04728
195102004916	ThiS interaction site; other site
195102004917	putative active site [active]
195102004918	tetramer interface [polypeptide binding]; other site
195102004919	ThiS-like ubiquitin; Region: ThiS-like; pfam14453
195102004920	thiamine biosynthesis protein ThiF; Provisional; Region: PRK08644
195102004921	E1_ThiF_like. Member of superfamily of activating enzymes (E1) of the ubiquitin-like proteins. The common reaction mechanism catalyzed by E1-like enzymes begins with a nucleophilic attack of the C-terminal carboxylate of the ubiquitin-like substrate, on...; Region: E1_ThiF_like; cd01487
195102004922	putative ATP binding site [chemical binding]; other site
195102004923	putative substrate interface [chemical binding]; other site
195102004924	ThiaminS ubiquitin-like sulfur carrier protein; Region: ThiS; cd00565
195102004925	thiS-thiF/thiG interaction site; other site
195102004926	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
195102004927	Major Facilitator Superfamily; Region: MFS_1; pfam07690
195102004928	putative substrate translocation pore; other site
195102004929	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
195102004930	putative substrate translocation pore; other site
195102004931	Nucleotidyltransferase (NT) domain of RelA- and SpoT-like ppGpp synthetases and hydrolases; Region: NT_Rel-Spo_like; cd05399
195102004932	synthetase active site [active]
195102004933	NTP binding site [chemical binding]; other site
195102004934	metal binding site [ion binding]; metal-binding site
195102004935	methionine sulfoxide reductase B; Provisional; Region: PRK00222
195102004936	Alpha/beta hydrolase family; Region: Abhydrolase_5; pfam12695
195102004937	Predicted xylanase/chitin deacetylase [Carbohydrate transport and metabolism]; Region: CDA1; COG0726
195102004938	Catalytic NodB homology domain of Streptococcus mutans polysaccharide deacetylase PgdA, Bacillus subtilis YheN, and similar proteins; Region: CE4_SmPgdA_like; cd10944
195102004939	NodB motif; other site
195102004940	active site
195102004941	catalytic site [active]
195102004942	Zn binding site [ion binding]; other site
195102004943	Uncharacterized conserved protein [Function unknown]; Region: COG0398
195102004944	SNARE associated Golgi protein; Region: SNARE_assoc; pfam09335
195102004945	KicB killing factor; Region: KicB; cl11468
195102004946	Membrane proteins related to metalloendopeptidases [Cell envelope biogenesis, outer membrane]; Region: NlpD; COG0739
195102004947	Peptidase family M23; Region: Peptidase_M23; pfam01551
195102004948	hypothetical protein; Provisional; Region: PRK13678
195102004949	Superfamily I DNA and RNA helicases [General function prediction only]; Region: COG3973
195102004950	Part of AAA domain; Region: AAA_19; pfam13245
195102004951	Domain of unknown function (DUF2383); Region: DUF2383; pfam09537
195102004952	Cation efflux family; Region: Cation_efflux; cl00316
195102004953	Fusaric acid resistance protein-like; Region: FUSC_2; pfam13515
195102004954	Bacterial SNF2 helicase associated; Region: SNF2_assoc; pfam08455
195102004955	SNF2 family N-terminal domain; Region: SNF2_N; pfam00176
195102004956	DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046
195102004957	ATP binding site [chemical binding]; other site
195102004958	putative Mg++ binding site [ion binding]; other site
195102004959	Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079
195102004960	nucleotide binding region [chemical binding]; other site
195102004961	ATP-binding site [chemical binding]; other site
195102004962	Transcriptional regulators [Transcription]; Region: PurR; COG1609
195102004963	Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392
195102004964	DNA binding site [nucleotide binding]
195102004965	domain linker motif; other site
195102004966	Ligand binding domain of the LacI tanscriptional regulator family belonging to the type I periplasmic-binding fold protein superfamily; Region: PBP1_LacI_sugar_binding_like; cd06267
195102004967	dimerization interface [polypeptide binding]; other site
195102004968	ligand binding site [chemical binding]; other site
195102004969	Type 1 periplasmic binding fold superfamily; Region: Periplasmic_Binding_Protein_Type_1; cl10011
195102004970	Type 1 periplasmic binding fold superfamily; Region: Periplasmic_Binding_Protein_Type_1; cl10011
195102004971	Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653
195102004972	Transmembrane subunit (TM) of Escherichia coli AraH and related proteins. E. coli AraH is the TM of a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of the monosaccharide arabinose. This group...; Region: TM_PBP1_transp_AraH_like; cd06579
195102004973	TM-ABC transporter signature motif; other site
195102004974	ABC-type sugar transport system, ATPase component [Carbohydrate transport and metabolism]; Region: MglA; COG1129
195102004975	First domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_I; cd03216
195102004976	Walker A/P-loop; other site
195102004977	ATP binding site [chemical binding]; other site
195102004978	Q-loop/lid; other site
195102004979	ABC transporter signature motif; other site
195102004980	Walker B; other site
195102004981	D-loop; other site
195102004982	H-loop/switch region; other site
195102004983	Second domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_II; cd03215
195102004984	D-ribose pyranase; Provisional; Region: PRK11797
195102004985	Sugar kinases, ribokinase family [Carbohydrate transport and metabolism]; Region: RbsK; COG0524
195102004986	Ribokinase catalyses the phosphorylation of ribose to ribose-5-phosphate using ATP. This reaction is the first step in the ribose metabolism. It traps ribose within the cell after uptake and also prepares the sugar for use in the synthesis of nucleotides...; Region: ribokinase; cd01174
195102004987	substrate binding site [chemical binding]; other site
195102004988	dimer interface [polypeptide binding]; other site
195102004989	ATP binding site [chemical binding]; other site
195102004990	Polypeptide or peptide deformylase; a family of metalloenzymes that catalyzes the removal of the N-terminal formyl group in a growing polypeptide chain following translation initiation during protein synthesis in prokaryotes. These enzymes utilize Fe(II)...; Region: Pep_deformylase; cd00487
195102004991	active site
195102004992	catalytic residues [active]
195102004993	metal binding site [ion binding]; metal-binding site
195102004994	UDP-N-acetylmuramyl pentapeptide phosphotransferase/UDP-N- acetylglucosamine-1-phosphate transferase [Cell envelope biogenesis, outer membrane]; Region: Rfe; COG0472
195102004995	This subfamily contains Escherichia coli WecA, Bacillus subtilis TagO and related proteins. WecA is an UDP-N-acetylglucosamine (GlcNAc):undecaprenyl-phosphate (Und-P) GlcNAc-1-phosphate transferase that catalyzes the formation of a phosphodiester bond...; Region: GT_WecA_like; cd06853
195102004996	Mg++ binding site [ion binding]; other site
195102004997	putative catalytic motif [active]
195102004998	substrate binding site [chemical binding]; other site
195102004999	Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090
195102005000	dimerization interface [polypeptide binding]; other site
195102005001	putative DNA binding site [nucleotide binding]; other site
195102005002	putative Zn2+ binding site [ion binding]; other site
195102005003	V-type ATP synthase subunit D; Reviewed; Region: PRK00373
195102005004	V-type ATP synthase subunit B; Provisional; Region: PRK04196
195102005005	ATP synthase alpha/beta family, beta-barrel domain; Region: ATP-synt_ab_N; pfam02874
195102005006	V/A-type ATP synthase (non-catalytic) subunit B. These ATPases couple ATP hydrolysis to the build up of a H+ gradient, but V-type ATPases do not catalyze the reverse reaction. The Vacuolar (V-type) ATPase is found in the membranes of vacuoles, the golgi...; Region: V_A-ATPase_B; cd01135
195102005007	Walker A motif homologous position; other site
195102005008	Walker B motif; other site
195102005009	ATP synthase alpha/beta chain, C terminal domain; Region: ATP-synt_ab_C; pfam00306
195102005010	V-type ATP synthase subunit A; Provisional; Region: PRK04192
195102005011	ATP synthase alpha/beta family, beta-barrel domain; Region: ATP-synt_ab_N; pfam02874
195102005012	V/A-type ATP synthase catalytic subunit A. These ATPases couple ATP hydrolysis to the build up of a H+ gradient, but V-type ATPases do not catalyze the reverse reaction.  The Vacuolar (V-type) ATPase is found in the membranes of vacuoles, the golgi...; Region: V_A-ATPase_A; cd01134
195102005013	Walker A motif/ATP binding site; other site
195102005014	Walker B motif; other site
195102005015	ATP synthase alpha/beta chain, C terminal domain; Region: ATP-synt_ab_C; pfam00306
195102005016	V-type ATP synthase subunit F; Provisional; Region: PRK01395
195102005017	V-type ATP synthase subunit C; Provisional; Region: PRK01198
195102005018	Archaeal/vacuolar-type H+-ATPase subunit C [Energy production and conversion]; Region: NtpC; COG1527
195102005019	Archaeal/vacuolar-type H+-ATPase subunit E [Energy production and conversion]; Region: NtpE; COG1390
195102005020	V-type ATP synthase subunit E; Provisional; Region: PRK03963; cl17074
195102005021	V-type ATP synthase subunit K; Validated; Region: PRK06558
195102005022	ATP synthase subunit C; Region: ATP-synt_C; pfam00137
195102005023	ATP synthase subunit C; Region: ATP-synt_C; pfam00137
195102005024	V-type ATP synthase subunit I; Validated; Region: PRK05771
195102005025	ATP synthase B/B' CF(0); Region: ATP-synt_B; cl17192
195102005026	Fe-S oxidoreductase [Energy production and conversion]; Region: COG1032
195102005027	B12 binding domain_like associated with radical SAM domain. This domain shows similarity with B12 (adenosylcobamide) binding domains found in several enzymes, such as glutamate mutase, methionine synthase and methylmalonyl-CoA mutase, but it lacks the...; Region: radical_SAM_B12_BD; cd02068
195102005028	Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335
195102005029	FeS/SAM binding site; other site
195102005030	Protein of unknown function (DUF4080); Region: DUF4080; pfam13311
195102005031	Glucose/sorbosone dehydrogenases [Carbohydrate transport and metabolism]; Region: COG2133
195102005032	stage V sporulation protein B; Region: spore_V_B; TIGR02900
195102005033	Stage V sporulation protein B, also known as Stage III sporulation protein F, and related proteins; Region: MATE_SpoVB_like; cd13124
195102005034	Predicted RNA-bindining protein (contains S1 and HTH domains) [General function prediction only]; Region: COG2996
195102005035	S1 domain; Region: S1_2; pfam13509
195102005036	S1 domain; Region: S1_2; pfam13509
195102005037	Carbonic anhydrases/acetyltransferases, isoleucine patch superfamily [General function prediction only]; Region: PaaY; COG0663
195102005038	Gamma carbonic anhydrase-like: This family is composed of gamma carbonic anhydrase (CA), Ferripyochelin Binding Protein (FBP), E. coli paaY protein, and similar proteins. CAs are zinc-containing enzymes that catalyze the reversible hydration of carbon...; Region: LbH_gamma_CA_like; cd04645
195102005039	trimer interface [polypeptide binding]; other site
195102005040	putative metal binding site [ion binding]; other site
195102005041	Polymerase and Histidinol Phosphatase domain; Region: PHP; cl17102
195102005042	active site
195102005043	AsnC-type helix-turn-helix domain; Region: HTH_AsnC-type; pfam13404
195102005044	AsnC family; Region: AsnC_trans_reg; pfam01037
195102005045	Uncharacterized conserved protein [Function unknown]; Region: COG2155
195102005046	Phosphoenolpyruvate carboxykinase (PEPCK), a critical gluconeogenic enzyme, catalyzes the first committed step in the diversion of tricarboxylic acid cycle intermediates toward gluconeogenesis. It catalyzes the reversible decarboxylation and...; Region: PEPCK_HprK; cl00270
195102005047	active site
195102005048	metal-binding site [ion binding]
195102005049	nucleotide-binding site [chemical binding]; other site
195102005050	Predicted hydrolase (metallo-beta-lactamase superfamily) [General function prediction only]; Region: ComEC; COG2333
195102005051	Metallo-beta-lactamase superfamily; Region: Lactamase_B; pfam00753
195102005052	RNase_H superfamily; Region: RNase_H_2; pfam13482
195102005053	Fe2+ transport system protein A [Inorganic ion transport and metabolism]; Region: FeoA; COG1918
195102005054	Fe2+ transport system protein B [Inorganic ion transport and metabolism]; Region: FeoB; COG0370
195102005055	Ferrous iron transport protein B (FeoB) family; Region: FeoB; cd01879
195102005056	G1 box; other site
195102005057	GTP/Mg2+ binding site [chemical binding]; other site
195102005058	Switch I region; other site
195102005059	G2 box; other site
195102005060	G3 box; other site
195102005061	Switch II region; other site
195102005062	G4 box; other site
195102005063	G5 box; other site
195102005064	Nucleoside recognition; Region: Gate; pfam07670
195102005065	Ferrous iron transport protein B C terminus; Region: FeoB_C; pfam07664
195102005066	Nucleoside recognition; Region: Gate; pfam07670
195102005067	arginyl-tRNA synthetase; Reviewed; Region: PRK12451
195102005068	Arginyl tRNA synthetase N terminal dom; Region: Arg_tRNA_synt_N; smart01016
195102005069	catalytic core domain of arginyl-tRNA synthetases; Region: ArgRS_core; cd00671
195102005070	active site
195102005071	HIGH motif; other site
195102005072	KMSK motif region; other site
195102005073	Anticodon-binding domain of arginyl tRNA synthetases; Region: Anticodon_Ia_Arg; cd07956
195102005074	tRNA binding surface [nucleotide binding]; other site
195102005075	anticodon binding site; other site
195102005076	Exopolyphosphatase [Nucleotide transport and metabolism / Inorganic ion transport and metabolism]; Region: GppA; COG0248
195102005077	Ppx/GppA phosphatase family; Region: Ppx-GppA; pfam02541
195102005078	Bacterial capsule synthesis protein PGA_cap; Region: PGA_cap; smart00854
195102005079	CapA and related proteins, metallophosphatase domain; Region: MPP_CapA; cd07381
195102005080	putative active site [active]
195102005081	putative metal binding site [ion binding]; other site
195102005082	Uncharacterized homologs of Site-2 protease (S2P), zinc metalloproteases (MEROPS family M50) which cleave transmembrane domains of substrate proteins, regulating intramembrane proteolysis (RIP) of diverse signal transduction mechanisms. Members of the...; Region: S2P-M50_like_1; cd06158
195102005083	Peptidase family M50; Region: Peptidase_M50; pfam02163
195102005084	active site
195102005085	putative substrate binding region [chemical binding]; other site
195102005086	NYN ribonuclease and ATPase of PhoH family domains [General    function prediction only]; Region: COG1875
195102005087	PIN domain of bacterial Smg6-like homologs with PhoH-like ATPase domains; Region: PIN_PhoHL-ATPase; cd09883
195102005088	putative active site [active]
195102005089	PhoH-like protein; Region: PhoH; pfam02562
195102005090	DNA polymerase III, epsilon subunit and related 3'-5' exonucleases [DNA replication, recombination, and repair]; Region: DnaQ; COG0847
195102005091	DEDDh 3'-5' exonuclease domain family; Region: DEDDh; cd06127
195102005092	active site
195102005093	catalytic site [active]
195102005094	substrate binding site [chemical binding]; other site
195102005095	SSB_OBF: A subfamily of OB folds similar to the OB fold of ssDNA-binding protein (SSB). SSBs bind with high affinity to ssDNA. They bind to and protect ssDNA intermediates during DNA metabolic pathways. All bacterial and eukaryotic SSBs studied to date...; Region: SSB_OBF; cd04496
195102005096	dimer interface [polypeptide binding]; other site
195102005097	ssDNA binding site [nucleotide binding]; other site
195102005098	tetramer (dimer of dimers) interface [polypeptide binding]; other site
195102005099	Adenylosuccinate lyase [Nucleotide transport and metabolism]; Region: PurB; COG0015
195102005100	Adenylsuccinate lyase (ASL)_subgroup 2; Region: Adenylsuccinate_lyase_2; cd03302
195102005101	tetramer interface [polypeptide binding]; other site
195102005102	active site
195102005103	Histidine-containing phosphocarrier protein (HPr)-like proteins. HPr is a central component of the bacterial phosphoenolpyruvate sugar phosphotransferase system (PTS). The PTS catalyses the phosphorylation of sugar substrates during their translocation...; Region: PTS-HPr_like; cd00367
195102005104	dimerization domain swap beta strand [polypeptide binding]; other site
195102005105	regulatory protein interface [polypeptide binding]; other site
195102005106	active site
195102005107	regulatory phosphorylation site [posttranslational modification]; other site
195102005108	aspartate aminotransferase; Provisional; Region: PRK05764
195102005109	Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609
195102005110	pyridoxal 5'-phosphate binding site [chemical binding]; other site
195102005111	homodimer interface [polypeptide binding]; other site
195102005112	catalytic residue [active]
195102005113	Stage V sporulation protein S (SpoVS); Region: SpoVS; pfam04232
195102005114	phosphodiesterase; Provisional; Region: PRK12704
195102005115	ATP synthase B/B' CF(0); Region: ATP-synt_B; cl17192
195102005116	Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077
195102005117	Zn2+ binding site [ion binding]; other site
195102005118	Mg2+ binding site [ion binding]; other site
195102005119	recombinase A; Provisional; Region: recA; PRK09354
195102005120	RecA is a  bacterial enzyme which has roles in homologous recombination, DNA repair, and the induction of the SOS response.  RecA couples ATP hydrolysis to DNA strand exchange; Region: recA; cd00983
195102005121	hexamer interface [polypeptide binding]; other site
195102005122	Walker A motif; other site
195102005123	ATP binding site [chemical binding]; other site
195102005124	Walker B motif; other site
195102005125	CDP-alcohol phosphatidyltransferase; Region: CDP-OH_P_transf; cl00453
195102005126	2-methylthioadenine synthetase [Translation, ribosomal structure and biogenesis]; Region: MiaB; COG0621
195102005127	Uncharacterized protein family UPF0004; Region: UPF0004; pfam00919
195102005128	Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335
195102005129	FeS/SAM binding site; other site
195102005130	Acyltransferase family; Region: Acyl_transf_3; pfam01757
195102005131	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
195102005132	DNA segregation ATPase FtsK/SpoIIIE and related proteins [Cell division and chromosome partitioning]; Region: FtsK; COG1674
195102005133	FtsK/SpoIIIE family; Region: FtsK_SpoIIIE; pfam01580
195102005134	Ftsk gamma domain; Region: Ftsk_gamma; pfam09397
195102005135	Caseinolytic protease (ClpP) is an ATP-dependent protease; Region: Clp_protease_like; cl15763
195102005136	active site
195102005137	aspartate kinase I; Reviewed; Region: PRK08210
195102005138	AAK_AKi-DapG-BS: Amino Acid Kinase Superfamily (AAK), AKi-DapG; this CD includes the N-terminal catalytic aspartokinase (AK) domain of  the diaminopimelate-sensitive aspartokinase isoenzyme AKI (DapG), a monofunctional class enzyme found in Bacilli; Region: AAK_AKi-DapG-BS; cd04260
195102005139	putative catalytic residues [active]
195102005140	putative nucleotide binding site [chemical binding]; other site
195102005141	putative aspartate binding site [chemical binding]; other site
195102005142	ACT domains of the diaminopimelate-sensitive aspartokinase (AK) isoenzyme AKI; Region: ACT_AKi-DapG-BS_1; cd04914
195102005143	ACT domains of the diaminopimelate-sensitive aspartokinase (AK) isoenzyme AKI; Region: ACT_AKi-DapG-BS_2; cd04937
195102005144	sporulation protein, YlmC/YmxH family; Region: spore_YlmC_YmxH; TIGR02888
195102005145	polynucleotide phosphorylase/polyadenylase; Provisional; Region: PRK11824
195102005146	Polyribonucleotide nucleotidyltransferase, repeat 1; Region: RNase_PH_PNPase_1; cd11363
195102005147	RNase E interface [polypeptide binding]; other site
195102005148	trimer interface [polypeptide binding]; other site
195102005149	Polyribonucleotide nucleotidyltransferase, RNA binding domain; Region: PNPase; pfam03726
195102005150	Polyribonucleotide nucleotidyltransferase, repeat 2; Region: RNase_PH_PNPase_2; cd11364
195102005151	RNase E interface [polypeptide binding]; other site
195102005152	trimer interface [polypeptide binding]; other site
195102005153	active site
195102005154	Polynucleotide phosphorylase (PNPase) K homology RNA-binding domain (KH). PNPase is a polyribonucleotide nucleotidyl transferase that degrades mRNA in prokaryotes and plant chloroplasts. The C-terminal region of PNPase contains domains homologous to...; Region: PNPase_KH; cd02393
195102005155	putative nucleic acid binding region [nucleotide binding]; other site
195102005156	G-X-X-G motif; other site
195102005157	S1_PNPase: Polynucleotide phosphorylase (PNPase), ), S1-like RNA-binding domain. PNPase  is a polyribonucleotide nucleotidyl transferase that degrades mRNA. It is a trimeric multidomain protein. The C-terminus contains the S1 domain which binds ssRNA; Region: S1_PNPase; cd04472
195102005158	RNA binding site [nucleotide binding]; other site
195102005159	domain interface; other site
195102005160	Ribosomal protein S15 (prokaryotic)_S13 (eukaryotic) binds the central domain of 16S rRNA and is required for assembly of the small ribosomal subunit and for intersubunit association, thus representing a key element in the assembly of the whole ribosome; Region: Ribosomal_S15p_S13e; cd00353
195102005161	16S/18S rRNA binding site [nucleotide binding]; other site
195102005162	S13e-L30e interaction site [polypeptide binding]; other site
195102005163	25S rRNA binding site [nucleotide binding]; other site
195102005164	bifunctional riboflavin kinase/FMN adenylyltransferase; Reviewed; Region: PRK05627
195102005165	FAD synthetase, N-terminal domain of the bifunctional enzyme; Region: FAD_synthetase_N; cd02064
195102005166	active site
195102005167	Riboflavin kinase; Region: Flavokinase; smart00904
195102005168	tRNA pseudouridine synthase B; Provisional; Region: truB; PRK00130
195102005169	Pseudouridine synthase, Escherichia coli TruB like; Region: PseudoU_synth_EcTruB; cd02573
195102005170	RNA binding site [nucleotide binding]; other site
195102005171	active site
195102005172	Pseudouridine synthase II TruB, C-terminal; Region: TruB-C_2; pfam09157
195102005173	Exopolyphosphatase-related proteins [General function prediction only]; Region: COG0618
195102005174	DHH family; Region: DHH; pfam01368
195102005175	DHHA1 domain; Region: DHHA1; pfam02272
195102005176	ribosome-binding factor A; Validated; Region: rbfA; PRK00521
195102005177	Translation initiation factor IF-2, N-terminal region; Region: IF2_N; pfam04760
195102005178	translation initiation factor IF-2; Region: IF-2; TIGR00487
195102005179	Translation initiation factor IF-2, N-terminal region; Region: IF2_N; pfam04760
195102005180	Initiation Factor 2 (IF2)/ eukaryotic Initiation Factor 5B (eIF5B) family; Region: IF2_eIF5B; cd01887
195102005181	G1 box; other site
195102005182	putative GEF interaction site [polypeptide binding]; other site
195102005183	GTP/Mg2+ binding site [chemical binding]; other site
195102005184	Switch I region; other site
195102005185	G2 box; other site
195102005186	G3 box; other site
195102005187	Switch II region; other site
195102005188	G4 box; other site
195102005189	G5 box; other site
195102005190	This family represents the domain II of bacterial Initiation Factor 2 (IF2) and its eukaryotic mitochondrial homologue mtIF2. IF2, the largest initiation factor is an essential GTP binding protein. In E. coli three natural forms of IF2 exist in the cell; Region: IF2_mtIF2_II; cd03702
195102005191	Translation-initiation factor 2; Region: IF-2; pfam11987
195102005192	mtIF2_IVc: this family represents the C2 subdomain of domain IV of mitochondrial translation initiation factor 2 (mtIF2) which adopts a beta-barrel fold displaying a high degree of structural similarity with domain II of the translation elongation factor...; Region: mtIF2_IVc; cd03692
195102005193	ribosomal protein L7Ae family protein; Provisional; Region: PRK05583
195102005194	Ylxr homologs; group of conserved hypothetical bacterial proteins of unknown function; structure revealed putative RNA binding cleft; proteins are encoded by an operon that includes other proteins involved in transcription and/or translation; Region: YlxR; cd00279
195102005195	putative RNA binding cleft [nucleotide binding]; other site
195102005196	transcription elongation factor NusA; Provisional; Region: nusA; PRK12327
195102005197	NusA N-terminal domain; Region: NusA_N; pfam08529
195102005198	S1_NusA: N-utilizing substance A protein (NusA), S1-like RNA-binding domain. S1-like RNA-binding domains are found in a wide variety of RNA-associated proteins. NusA is a transcription elongation factor containing an N-terminal catalytic domain and three...; Region: S1_NusA; cd04455
195102005199	RNA binding site [nucleotide binding]; other site
195102005200	homodimer interface [polypeptide binding]; other site
195102005201	NusA-like KH domain; Region: KH_5; pfam13184
195102005202	NusA_K homology RNA-binding domain (KH). NusA is an essential multifunctional transcription elongation factor that is universally conserved among prokaryotes and archaea. NusA anti-termination function plays an important role in the expression of...; Region: NusA_KH; cd02134
195102005203	G-X-X-G motif; other site
195102005204	ribosome maturation protein RimP; Reviewed; Region: PRK00092
195102005205	Sm and related proteins; Region: Sm_like; cl00259
195102005206	Bacillus subtilis YxlS-like, C-terminal domain; Region: YlxS_C; cd01734
195102005207	putative oligomer interface [polypeptide binding]; other site
195102005208	putative RNA binding site [nucleotide binding]; other site
195102005209	DNA polymerase III PolC; Validated; Region: polC; PRK00448
195102005210	DNA polymerase III polC-type N-terminus; Region: DNA_pol3_alph_N; pfam11490
195102005211	polC_OBF: A subfamily of OB folds corresponding to the N-terminal OB-fold nucleic acid binding domain of Bacillus subtilis type C replicative DNA polymerase III alpha subunit (polC). Replication in B. subtilis and Staphylococcus aureus requires two...; Region: polC_OBF; cd04484
195102005212	generic binding surface II; other site
195102005213	generic binding surface I; other site
195102005214	Polymerase and Histidinol Phosphatase domain; Region: PHP; cl17102
195102005215	active site
195102005216	DEDDh 3'-5' exonuclease domain family; Region: DEDDh; cd06127
195102005217	active site
195102005218	catalytic site [active]
195102005219	substrate binding site [chemical binding]; other site
195102005220	Polymerase and Histidinol Phosphatase domain of alpha-subunit of bacterial polymerase III at PolC gene; Region: PHP_PolIIIA_POLC; cd07435
195102005221	4-hydroxy-3-methylbut-2-en-1-yl diphosphate synthase; Reviewed; Region: ispG; PRK00366
195102005222	4-hydroxy-3-methylbut-2-en-1-yl diphosphate synthase; Validated; Region: PRK00694
195102005223	4-hydroxy-3-methylbut-2-en-1-yl diphosphate synthase; Validated; Region: PRK00694
195102005224	Predicted membrane-associated Zn-dependent proteases 1 [Cell envelope biogenesis, outer membrane]; Region: COG0750
195102005225	RseP-like Site-2 proteases (S2P), zinc metalloproteases (MEROPS family M50A), cleave transmembrane domains of substrate proteins, regulating intramembrane proteolysis (RIP) of diverse signal transduction mechanisms. In Escherichia coli, the S2P homolog...; Region: S2P-M50_PDZ_RseP-like; cd06163
195102005226	active site
195102005227	PDZ domain of bacterial and plant zinc metalloprotases, presumably membrane-associated or integral membrane proteases, which may be involved in signalling and regulatory mechanisms. May be responsible for substrate recognition and/or binding, as most PDZ...; Region: PDZ_metalloprotease; cd00989
195102005228	protein binding site [polypeptide binding]; other site
195102005229	Site-2 protease (S2P) class of zinc metalloproteases (MEROPS family M50) cleaves transmembrane domains of substrate proteins, regulating intramembrane proteolysis (RIP) of diverse signal transduction mechanisms. Members of this family use proteolytic...; Region: S2P-M50; cl10020
195102005230	putative substrate binding region [chemical binding]; other site
195102005231	1-deoxy-D-xylulose 5-phosphate reductoisomerase; Provisional; Region: PRK05447
195102005232	1-deoxy-D-xylulose 5-phosphate reductoisomerase; Region: DXP_reductoisom; pfam02670
195102005233	1-deoxy-D-xylulose 5-phosphate reductoisomerase C-terminal; Region: DXP_redisom_C; pfam08436
195102005234	DXP reductoisomerase C-terminal domain; Region: DXPR_C; pfam13288
195102005235	CDP-diglyceride synthetase [Lipid metabolism]; Region: CdsA; COG0575
195102005236	Cytidylyltransferase family; Region: CTP_transf_1; pfam01148
195102005237	Undecaprenyl pyrophosphate synthase [Lipid metabolism]; Region: UppS; COG0020
195102005238	Cis (Z)-Isoprenyl Diphosphate Synthases (cis-IPPS); homodimers which catalyze the successive 1'-4 condensation of the isopentenyl diphosphate (IPP) molecule to trans,trans-farnesyl diphosphate (FPP) or to cis,trans-FPP to form long-chain polyprenyl...; Region: CIS_IPPS; cd00475
195102005239	catalytic residue [active]
195102005240	putative FPP diphosphate  binding site; other site
195102005241	putative FPP binding hydrophobic cleft; other site
195102005242	dimer interface [polypeptide binding]; other site
195102005243	putative IPP diphosphate binding site; other site
195102005244	ribosome recycling factor; Reviewed; Region: frr; PRK00083
195102005245	Ribosome recycling factor (RRF). Ribosome recycling factor dissociates the posttermination complex, composed of the ribosome, deacylated tRNA, and mRNA, after termination of translation.  Thus ribosomes are "recycled" and ready for another...; Region: RRF; cd00520
195102005246	hinge region; other site
195102005247	UMP kinase (UMPK)-Ec, the microbial/chloroplast uridine monophosphate kinase (uridylate kinase) enzyme that catalyzes UMP phosphorylation and plays a key role in pyrimidine nucleotide biosynthesis; regulation of this process is via feed-back control and...; Region: AAK_UMPK-PyrH-Ec; cd04254
195102005248	putative nucleotide binding site [chemical binding]; other site
195102005249	uridine monophosphate binding site [chemical binding]; other site
195102005250	homohexameric interface [polypeptide binding]; other site
195102005251	elongation factor Ts; Provisional; Region: tsf; PRK09377
195102005252	UBA/TS-N domain; Region: UBA; pfam00627
195102005253	Elongation factor TS; Region: EF_TS; pfam00889
195102005254	Elongation factor TS; Region: EF_TS; pfam00889
195102005255	Ribosomal protein S2 (RPS2), involved in formation of the translation initiation complex, where it might contact the messenger RNA and several components of the ribosome. It has been shown that in Escherichia coli RPS2 is essential for the binding of...; Region: RPS2; cd01425
195102005256	rRNA interaction site [nucleotide binding]; other site
195102005257	S8 interaction site; other site
195102005258	putative laminin-1 binding site; other site
195102005259	transcriptional repressor CodY; Validated; Region: PRK04158
195102005260	CodY GAF-like domain; Region: CodY; pfam06018
195102005261	CodY helix-turn-helix domain; Region: HTH_CodY; pfam08222
195102005262	DNA topoisomerase I; Validated; Region: PRK05582
195102005263	TOPRIM_TopoIA_TopoI: The topoisomerase-primase (TORPIM) domain found in members of the type IA family of DNA topoisomerases (Topo IA) similar to Escherichia coli DNA topoisomerase I.   Type IA DNA topoisomerases remove (relax) negative supercoils in the...; Region: TOPRIM_TopoIA_TopoI; cd03363
195102005264	active site
195102005265	interdomain interaction site; other site
195102005266	putative metal-binding site [ion binding]; other site
195102005267	nucleotide binding site [chemical binding]; other site
195102005268	DNA Topoisomerase, subtype IA; DNA-binding, ATP-binding and catalytic domain of bacterial DNA topoisomerases I and III, and eukaryotic DNA topoisomerase III and eubacterial and archael reverse gyrases. Topoisomerases clevage single or double stranded DNA...; Region: TOP1Ac; cd00186
195102005269	domain I; other site
195102005270	DNA binding groove [nucleotide binding]
195102005271	phosphate binding site [ion binding]; other site
195102005272	domain II; other site
195102005273	domain III; other site
195102005274	nucleotide binding site [chemical binding]; other site
195102005275	catalytic site [active]
195102005276	domain IV; other site
195102005277	Topoisomerase DNA binding C4 zinc finger; Region: zf-C4_Topoisom; pfam01396
195102005278	Topoisomerase DNA binding C4 zinc finger; Region: zf-C4_Topoisom; pfam01396
195102005279	Topoisomerase DNA binding C4 zinc finger; Region: zf-C4_Topoisom; pfam01396
195102005280	DNA protecting protein DprA; Region: dprA; TIGR00732
195102005281	DNA recombination-mediator protein A; Region: DNA_processg_A; pfam02481
195102005282	Predicted ATPase with chaperone activity [Posttranslational modification, protein turnover, chaperones]; Region: COG0606
195102005283	Subunit ChlI of Mg-chelatase; Region: ChlI; pfam13541
195102005284	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
195102005285	Walker A motif; other site
195102005286	ATP binding site [chemical binding]; other site
195102005287	Walker B motif; other site
195102005288	Magnesium chelatase, subunit ChlI; Region: Mg_chelatase_2; pfam13335
195102005289	hypothetical protein; Reviewed; Region: PRK12497
195102005290	bacterial Ribonuclease HII-like; Region: RNase_HII_bacteria_HII_like; cd07182
195102005291	RNA/DNA hybrid binding site [nucleotide binding]; other site
195102005292	active site
195102005293	GTPase YlqF; Reviewed; Region: rbgA; PRK09563
195102005294	Circularly permuted YlqF GTPase; Region: YlqF; cd01856
195102005295	GTP/Mg2+ binding site [chemical binding]; other site
195102005296	G4 box; other site
195102005297	G5 box; other site
195102005298	50S ribosome-binding GTPase; Region: MMR_HSR1; pfam01926
195102005299	G1 box; other site
195102005300	Switch I region; other site
195102005301	G2 box; other site
195102005302	G3 box; other site
195102005303	Switch II region; other site
195102005304	50S ribosomal protein L19; Provisional; Region: rplS; PRK05338
195102005305	tRNA (guanine-N(1)-)-methyltransferase; Reviewed; Region: trmD; PRK00026
195102005306	16S rRNA-processing protein RimM; Provisional; Region: rimM; PRK00122
195102005307	RimM N-terminal domain; Region: RimM; pfam01782
195102005308	PRC-barrel domain; Region: PRC; pfam05239
195102005309	Predicted RNA-binding protein (contains KH domain) [General function prediction only]; Region: COG1837
195102005310	hypothetical protein; Provisional; Region: PRK00468
195102005311	30S ribosomal protein S16; Reviewed; Region: rpsP; PRK00040
195102005312	signal recognition particle protein; Provisional; Region: PRK10867
195102005313	SRP54-type protein, helical bundle domain; Region: SRP54_N; smart00963
195102005314	The signal recognition particle (SRP) mediates the transport to or across the plasma membrane in bacteria and the endoplasmic reticulum in eukaryotes. SRP recognizes N-terminal sighnal sequences of newly synthesized polypeptides at the ribosome. The...; Region: SRP; cd03115
195102005315	P loop; other site
195102005316	GTP binding site [chemical binding]; other site
195102005317	Signal peptide binding domain; Region: SRP_SPB; pfam02978
195102005318	putative DNA-binding protein; Validated; Region: PRK00118
195102005319	Putative helix-turn-helix protein, YlxM / p13 like; Region: UPF0122; pfam04297
195102005320	signal recognition particle-docking protein FtsY; Provisional; Region: PRK10416
195102005321	SRP54-type protein, helical bundle domain; Region: SRP54_N; pfam02881
195102005322	The signal recognition particle (SRP) mediates the transport to or across the plasma membrane in bacteria and the endoplasmic reticulum in eukaryotes. SRP recognizes N-terminal sighnal sequences of newly synthesized polypeptides at the ribosome. The...; Region: SRP; cd03115
195102005323	P loop; other site
195102005324	GTP binding site [chemical binding]; other site
195102005325	chromosome segregation protein SMC, common bacterial type; Region: SMC_prok_B; TIGR02168
195102005326	ATP-binding cassette domain of barmotin, a member of the SMC protein family; Region: ABC_SMC_barmotin; cd03278
195102005327	Walker A/P-loop; other site
195102005328	ATP binding site [chemical binding]; other site
195102005329	Q-loop/lid; other site
195102005330	SMC proteins Flexible Hinge Domain; Region: SMC_hinge; smart00968
195102005331	ATP-binding cassette domain of barmotin, a member of the SMC protein family; Region: ABC_SMC_barmotin; cd03278
195102005332	ABC transporter signature motif; other site
195102005333	Walker B; other site
195102005334	D-loop; other site
195102005335	H-loop/switch region; other site
195102005336	Elongator protein 3, MiaB family, Radical SAM; Region: Elp3; smart00729
195102005337	Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335
195102005338	FeS/SAM binding site; other site
195102005339	ribonuclease III; Reviewed; Region: rnc; PRK00102
195102005340	RIBOc. Ribonuclease III C terminal domain. This group consists of eukaryotic, bacterial and archeal ribonuclease III (RNAse III) proteins. RNAse III is a double stranded RNA-specific endonuclease. Prokaryotic RNAse III is important in...; Region: RIBOc; cd00593
195102005341	dimerization interface [polypeptide binding]; other site
195102005342	active site
195102005343	metal binding site [ion binding]; metal-binding site
195102005344	Double-stranded RNA binding motif. Binding is not sequence specific but is highly specific for double stranded RNA. Found in a variety of proteins including dsRNA dependent protein kinase PKR, RNA helicases, Drosophila staufen protein, E. coli RNase III; Region: DSRM; cd00048
195102005345	dsRNA binding site [nucleotide binding]; other site
195102005346	acyl carrier protein; Provisional; Region: acpP; PRK00982
195102005347	putative phosphate acyltransferase; Provisional; Region: PRK05331
195102005348	Fatty acid synthesis protein; Region: FA_synthesis; cl17261
195102005349	50S ribosomal protein L32; Reviewed; Region: rpmF; PRK12286
195102005350	Uncharacterized ACR, COG1399; Region: DUF177; pfam02620
195102005351	acetate kinase A/propionate kinase 2; Reviewed; Region: PRK00180
195102005352	propionate/acetate kinase; Provisional; Region: PRK12379
195102005353	phosphotransacetylase; Reviewed; Region: eutD; PRK09653
195102005354	hypothetical protein; Provisional; Region: PRK13670
195102005355	HIGH Nucleotidyl Transferase; Region: HIGH_NTase1; cl17673
195102005356	sporulation integral membrane protein YlbJ; Region: spore_ylbJ; TIGR02871
195102005357	Nucleoside recognition; Region: Gate; pfam07670
195102005358	Cell division initiation protein [Cell division and chromosome partitioning]; Region: DivIVA; COG3599
195102005359	phosphopantetheine adenylyltransferase; Provisional; Region: coaD; PRK00168
195102005360	Phosphopantetheine adenylyltransferase; Region: PPAT; cd02163
195102005361	active site
195102005362	(T/H)XGH motif; other site
195102005363	Conserved hypothetical protein 95; Region: Cons_hypoth95; pfam03602
195102005364	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
195102005365	S-adenosylmethionine binding site [chemical binding]; other site
195102005366	ATP-dependent DNA helicase RecG; Provisional; Region: PRK10917
195102005367	Uncharacterized conserved protein [Function unknown]; Region: COG3743
195102005368	RecG_wedge_OBF: A subfamily of OB folds corresponding to the OB fold found in the N-terminal (wedge) domain of Escherichia coli RecG. RecG is a branched-DNA-specific helicase, which catalyzes the interconversion of a DNA replication fork to a...; Region: RecG_wedge_OBF; cd04488
195102005369	ssDNA binding site; other site
195102005370	generic binding surface II; other site
195102005371	DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046
195102005372	ATP binding site [chemical binding]; other site
195102005373	putative Mg++ binding site [ion binding]; other site
195102005374	Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079
195102005375	nucleotide binding region [chemical binding]; other site
195102005376	ATP-binding site [chemical binding]; other site
195102005377	DAK2 domain fusion protein YloV; Region: YloV; TIGR03599
195102005378	DAK2 domain; Region: Dak2; pfam02734
195102005379	Asp23 family; Region: Asp23; pfam03780
195102005380	50S ribosomal protein L28; Reviewed; Region: rpmB; PRK00359
195102005381	Thiamine pyrophosphokinase; Region: TPK; cd07995
195102005382	thiamine pyrophosphokinase; Region: thi_PPkinase; TIGR01378
195102005383	active site
195102005384	dimerization interface [polypeptide binding]; other site
195102005385	thiamine binding site [chemical binding]; other site
195102005386	Pentose-5-phosphate-3-epimerase [Carbohydrate transport and metabolism]; Region: Rpe; COG0036
195102005387	Ribulose-5-phosphate 3-epimerase (RPE). This enzyme catalyses the interconversion of D-ribulose 5-phosphate (Ru5P) into D-xylulose 5-phosphate, as part of the Calvin cycle (reductive pentose phosphate pathway) in chloroplasts and in the oxidative pentose...; Region: RPE; cd00429
195102005388	substrate binding site [chemical binding]; other site
195102005389	hexamer interface [polypeptide binding]; other site
195102005390	metal binding site [ion binding]; metal-binding site
195102005391	GTPase RsgA; Reviewed; Region: PRK00098
195102005392	S1_YloQ_GTPase: YloQ GTase family (also known as YjeQ and CpgA), S1-like RNA-binding domain. Proteins in the YloQ GTase family bind the ribosome and have GTPase activity. The precise role of this family is unknown. The protein structure is composed of...; Region: S1_YloQ_GTPase; cd04466
195102005393	RNA binding site [nucleotide binding]; other site
195102005394	homodimer interface [polypeptide binding]; other site
195102005395	Ribosomal interacting GTPase YjeQ/EngC, a circularly permuted subfamily of the Ras GTPases; Region: YjeQ_EngC; cd01854
195102005396	GTPase/Zn-binding domain interface [polypeptide binding]; other site
195102005397	GTP/Mg2+ binding site [chemical binding]; other site
195102005398	G4 box; other site
195102005399	G5 box; other site
195102005400	G1 box; other site
195102005401	Switch I region; other site
195102005402	G2 box; other site
195102005403	G3 box; other site
195102005404	Switch II region; other site
195102005405	Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220
195102005406	Catalytic domain of Protein Kinases; Region: PKc; cd00180
195102005407	active site
195102005408	ATP binding site [chemical binding]; other site
195102005409	substrate binding site [chemical binding]; other site
195102005410	activation loop (A-loop); other site
195102005411	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2815
195102005412	PASTA domain of bacterial serine/threonine kinase pknB-like proteins. PknB is a member of a group of related transmembrane sensor kinases present in many gram positive bacteria, which has been shown to regulate cell shape in Mycobacterium tubercolosis; Region: PASTA_pknB; cd06577
195102005413	PASTA domain of bacterial serine/threonine kinase pknB-like proteins. PknB is a member of a group of related transmembrane sensor kinases present in many gram positive bacteria, which has been shown to regulate cell shape in Mycobacterium tubercolosis; Region: PASTA_pknB; cd06577
195102005414	PASTA domain of bacterial serine/threonine kinase pknB-like proteins. PknB is a member of a group of related transmembrane sensor kinases present in many gram positive bacteria, which has been shown to regulate cell shape in Mycobacterium tubercolosis; Region: PASTA_pknB; cd06577
195102005415	Serine/threonine phosphatases, family 2C, catalytic domain; The protein architecture and deduced catalytic mechanism of PP2C phosphatases are similar to the PP1, PP2A, PP2B family of protein Ser/Thr phosphatases, with which PP2C shares no sequence...; Region: PP2Cc; cd00143
195102005416	Protein phosphatase 2C; Region: PP2C; pfam00481
195102005417	active site
195102005418	ribosomal RNA large subunit methyltransferase N; Provisional; Region: PRK14454
195102005419	Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335
195102005420	FeS/SAM binding site; other site
195102005421	16S rRNA methyltransferase B; Provisional; Region: PRK14902
195102005422	NusB family; Region: NusB; pfam01029
195102005423	putative RNA binding site [nucleotide binding]; other site
195102005424	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
195102005425	S-adenosylmethionine binding site [chemical binding]; other site
195102005426	Putative neutral zinc metallopeptidase; Region: Zn_peptidase_2; pfam04298
195102005427	methionyl-tRNA formyltransferase; Reviewed; Region: fmt; PRK00005
195102005428	Methionyl-tRNA formyltransferase, N-terminal hydrolase domain; Region: FMT_core_Met-tRNA-FMT_N; cd08646
195102005429	putative active site [active]
195102005430	substrate binding site [chemical binding]; other site
195102005431	putative cosubstrate binding site; other site
195102005432	catalytic site [active]
195102005433	C-terminal domain of Formyltransferase and other enzymes; Region: Met_tRNA_FMT_C; cd08704
195102005434	substrate binding site [chemical binding]; other site
195102005435	Polypeptide or peptide deformylase; a family of metalloenzymes that catalyzes the removal of the N-terminal formyl group in a growing polypeptide chain following translation initiation during protein synthesis in prokaryotes. These enzymes utilize Fe(II)...; Region: Pep_deformylase; cd00487
195102005436	active site
195102005437	catalytic residues [active]
195102005438	metal binding site [ion binding]; metal-binding site
195102005439	primosome assembly protein PriA; Validated; Region: PRK05580
195102005440	DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046
195102005441	ATP binding site [chemical binding]; other site
195102005442	putative Mg++ binding site [ion binding]; other site
195102005443	Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079
195102005444	nucleotide binding region [chemical binding]; other site
195102005445	ATP-binding site [chemical binding]; other site
195102005446	bifunctional phosphopantothenoylcysteine decarboxylase/phosphopantothenate synthase; Validated; Region: PRK05579
195102005447	Flavoprotein; Region: Flavoprotein; pfam02441
195102005448	DNA / pantothenate metabolism flavoprotein; Region: DFP; pfam04127
195102005449	DNA-directed RNA polymerase subunit omega; Reviewed; Region: rpoZ; PRK00392
195102005450	Guanylate kinase [Nucleotide transport and metabolism]; Region: Gmk; COG0194
195102005451	Guanosine monophosphate kinase (GMPK, EC 2.7.4.8), also known as guanylate kinase (GKase), catalyzes the reversible phosphoryl transfer from adenosine triphosphate (ATP) to guanosine monophosphate (GMP) to yield adenosine diphosphate (ADP) and guanosine...; Region: GMPK; cd00071
195102005452	catalytic site [active]
195102005453	G-X2-G-X-G-K; other site
195102005454	hypothetical protein; Provisional; Region: PRK04323
195102005455	hypothetical protein; Provisional; Region: PRK11820
195102005456	YicC-like family, N-terminal region; Region: YicC_N; pfam03755
195102005457	Domain of unknown function (DUF1732); Region: DUF1732; pfam08340
195102005458	Xanthine/uracil/vitamin C permease [Nucleotide transport and    metabolism]; Region: COG2252
195102005459	Type II (periplasmic) bacterial L-asparaginase; Region: L-asparaginase_II; cd08964
195102005460	active site
195102005461	homotetramer interface [polypeptide binding]; other site
195102005462	homodimer interface [polypeptide binding]; other site
195102005463	stage IV sporulation protein A; Region: spore_IV_A; TIGR02836
195102005464	Rat sarcoma (Ras)-like superfamily of small guanosine triphosphatases (GTPases); Region: Ras_like_GTPase; cd00882
195102005465	G1 box; other site
195102005466	GTP/Mg2+ binding site [chemical binding]; other site
195102005467	G2 box; other site
195102005468	Switch I region; other site
195102005469	G3 box; other site
195102005470	Switch II region; other site
195102005471	G5 box; other site
195102005472	NAD(P)H-dependent glycerol-3-phosphate dehydrogenase; Validated; Region: gpsA; PRK00094
195102005473	NAD-dependent glycerol-3-phosphate dehydrogenase N-terminus; Region: NAD_Gly3P_dh_N; pfam01210
195102005474	NAD-dependent glycerol-3-phosphate dehydrogenase C-terminus; Region: NAD_Gly3P_dh_C; pfam07479
195102005475	GTP-binding protein Der; Reviewed; Region: PRK00093
195102005476	EngA1 GTPase contains the first domain of EngA; Region: EngA1; cd01894
195102005477	G1 box; other site
195102005478	GTP/Mg2+ binding site [chemical binding]; other site
195102005479	Switch I region; other site
195102005480	G2 box; other site
195102005481	Switch II region; other site
195102005482	G3 box; other site
195102005483	G4 box; other site
195102005484	G5 box; other site
195102005485	EngA2 GTPase contains the second domain of EngA; Region: EngA2; cd01895
195102005486	G1 box; other site
195102005487	GTP/Mg2+ binding site [chemical binding]; other site
195102005488	Switch I region; other site
195102005489	G2 box; other site
195102005490	G3 box; other site
195102005491	Switch II region; other site
195102005492	G4 box; other site
195102005493	G5 box; other site
195102005494	putative FeS-containing Cyanobacterial-specific oxidoreductase; Region: cyano_FeS_chp; TIGR03279
195102005495	PDZ domain of tryspin-like serine proteases, such as DegP/HtrA, which are oligomeric proteins involved in heat-shock response, chaperone function, and apoptosis. May be responsible for substrate recognition and/or binding, as most PDZ domains bind...; Region: PDZ_serine_protease; cd00987
195102005496	Protein of unknown function (DUF512); Region: DUF512; pfam04459
195102005497	Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321
195102005498	Methyl-accepting chemotaxis protein [Cell motility and secretion / Signal transduction mechanisms]; Region: Tar; COG0840
195102005499	Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225
195102005500	dimerization interface [polypeptide binding]; other site
195102005501	phosphate regulon sensor kinase PhoR; Region: phoR_proteo; TIGR02966
195102005502	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
195102005503	putative active site [active]
195102005504	heme pocket [chemical binding]; other site
195102005505	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
195102005506	dimer interface [polypeptide binding]; other site
195102005507	phosphorylation site [posttranslational modification]
195102005508	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
195102005509	ATP binding site [chemical binding]; other site
195102005510	Mg2+ binding site [ion binding]; other site
195102005511	G-X-G motif; other site
195102005512	Multi-copper polyphenol oxidoreductase laccase; Region: Cu-oxidase_4; pfam02578
195102005513	Multicopper polyphenol oxidase (laccase) [Secondary metabolites biosynthesis, transport and catabolism]; Region: yfiH; COG1496
195102005514	transcriptional regulator NrdR; Validated; Region: nrdR; PRK00464
195102005515	ATP cone domain; Region: ATP-cone; pfam03477
195102005516	sporulation protein, YlmC/YmxH family; Region: spore_YlmC_YmxH; TIGR02888
195102005517	sporulation sigma factor SigG; Reviewed; Region: PRK08215
195102005518	Sigma-70 region 2; Region: Sigma70_r2; pfam04542
195102005519	Sigma-70 region 3; Region: Sigma70_r3; pfam04539
195102005520	Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171
195102005521	DNA binding residues [nucleotide binding]
195102005522	sporulation sigma factor SigE; Reviewed; Region: PRK08301
195102005523	Sigma-70 region 2; Region: Sigma70_r2; pfam04542
195102005524	Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171
195102005525	DNA binding residues [nucleotide binding]
195102005526	Sporulation factor SpoIIGA; Region: Peptidase_U4; pfam03419
195102005527	sigma-E processing peptidase SpoIIGA; Region: spore_II_GA; TIGR02854
195102005528	cell division protein FtsZ; Validated; Region: PRK09330
195102005529	FtsZ is a GTPase that is similar to the eukaryotic tubulins and is essential for cell division in prokaryotes.  FtsZ is capable of polymerizing in a GTP-driven process into structures similar to those formed by tubulin. FtsZ forms a ring-shaped septum at...; Region: FtsZ_type1; cd02201
195102005530	nucleotide binding site [chemical binding]; other site
195102005531	SulA interaction site; other site
195102005532	cell division protein FtsA; Region: ftsA; TIGR01174
195102005533	Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cd00012
195102005534	nucleotide binding site [chemical binding]; other site
195102005535	Cell division protein FtsA; Region: FtsA; pfam14450
195102005536	Tfp pilus assembly protein, pilus retraction ATPase PilT [Cell motility and secretion / Intracellular trafficking and secretion]; Region: PilT; COG2805
195102005537	RecA-like NTPases. This family includes the NTP binding domain of F1 and V1 H+ATPases, DnaB and related helicases as well as bacterial RecA and related eukaryotic and archaeal recombinases. This group also includes bacterial conjugation proteins and...; Region: RecA-like_NTPases; cl17233
195102005538	Walker A motif; other site
195102005539	ATP binding site [chemical binding]; other site
195102005540	Walker B motif; other site
195102005541	RNA polymerase sigma-K factor; Region: spore_sigmaK; TIGR02846
195102005542	Sigma-70 region 2; Region: Sigma70_r2; pfam04542
195102005543	Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171
195102005544	DNA binding residues [nucleotide binding]
195102005545	Cell division protein FtsI/penicillin-binding protein 2 [Cell envelope biogenesis, outer membrane]; Region: FtsI; COG0768
195102005546	Penicillin binding protein transpeptidase domain; Region: Transpeptidase; pfam00905
195102005547	Uridine monophosphate kinase (UMPK, EC 2.7.1.48), also known as uridine kinase or uridine-cytidine kinase (UCK), catalyzes the reversible phosphoryl transfer from ATP to uridine or cytidine to yield UMP or CMP. In the primidine nucleotide-salvage pathway; Region: UMPK; cd02023
195102005548	Uridine kinase [Nucleotide transport and metabolism]; Region: Udk; COG0572
195102005549	Sugar specificity; other site
195102005550	Pyrimidine base specificity; other site
195102005551	ATP-binding site [chemical binding]; other site
195102005552	Collagenase and related proteases [Posttranslational modification, protein turnover, chaperones]; Region: COG0826
195102005553	Peptidase family U32; Region: Peptidase_U32; pfam01136
195102005554	Predicted O-methyltransferase [General function prediction only]; Region: COG4122
195102005555	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
195102005556	S-adenosylmethionine binding site [chemical binding]; other site
195102005557	YceG-like family; Region: YceG; pfam02618
195102005558	proteins similar to Escherichia coli yceG; Region: yceG_like; cd08010
195102005559	dimerization interface [polypeptide binding]; other site
195102005560	Predicted membrane GTPase involved in stress response [Signal transduction mechanisms]; Region: TypA; COG1217
195102005561	Tyrosine phosphorylated protein A (TypA)/BipA family belongs to ribosome-binding GTPases; Region: TypA_BipA; cd01891
195102005562	G1 box; other site
195102005563	putative GEF interaction site [polypeptide binding]; other site
195102005564	GTP/Mg2+ binding site [chemical binding]; other site
195102005565	Switch I region; other site
195102005566	G2 box; other site
195102005567	G3 box; other site
195102005568	Switch II region; other site
195102005569	G4 box; other site
195102005570	G5 box; other site
195102005571	BipA_TypA_II: domain II of BipA (also called TypA) having homology to domain II of the elongation factors (EFs) EF-G and EF-Tu.  BipA is a highly conserved protein with global regulatory properties in Escherichia coli. BipA is phosphorylated on a...; Region: BipA_TypA_II; cd03691
195102005572	BipA_TypA_C: a C-terminal portion of BipA or TypA having homology to the C terminal domains of the elongation factors EF-G and EF-2. A member of the ribosome binding GTPase superfamily, BipA is widely distributed in bacteria and plants.  BipA is a highly...; Region: BipA_TypA_C; cd03710
195102005573	mRNA degradation ribonucleases J1/J2 (metallo-beta-lactamase superfamily) [Translation, ribosomal structure and biogenesis; Replication, recombination and repair]; Region: COG0595
195102005574	Metallo-beta-lactamase superfamily; Region: Lactamase_B; smart00849
195102005575	RNA-metabolising metallo-beta-lactamase; Region: RMMBL; pfam07521
195102005576	Ferric uptake regulator(Fur) and related metalloregulatory proteins; typically iron-dependent, DNA-binding repressors and activators; Region: Fur_like; cd07153
195102005577	metal binding site 2 [ion binding]; metal-binding site
195102005578	putative DNA binding helix; other site
195102005579	metal binding site 1 [ion binding]; metal-binding site
195102005580	dimer interface [polypeptide binding]; other site
195102005581	structural Zn2+ binding site [ion binding]; other site
195102005582	hypothetical protein; Provisional; Region: PRK13678
195102005583	Holliday junction resolvase-like protein; Reviewed; Region: PRK00109
195102005584	hypothetical protein; Provisional; Region: PRK05473
195102005585	alanyl-tRNA synthetase; Reviewed; Region: alaS; PRK00252
195102005586	Alanyl-tRNA synthetase (AlaRS) class II core catalytic domain. AlaRS is a homodimer. It is responsible for the attachment of alanine to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for ATP-dependent...; Region: AlaRS_core; cd00673
195102005587	motif 1; other site
195102005588	active site
195102005589	motif 2; other site
195102005590	motif 3; other site
195102005591	Class II tRNA amino-acyl synthetase-like catalytic core domain. Class II amino acyl-tRNA synthetases (aaRS) share a common fold and generally attach an amino acid to the 3' OH of ribose of the appropriate tRNA.   PheRS is an exception in that it...; Region: class_II_aaRS-like_core; cl00268
195102005592	Threonyl and Alanyl tRNA synthetase second additional domain; Region: tRNA_SAD; smart00863
195102005593	Domain of unknown function DUF20; Region: UPF0118; pfam01594
195102005594	Predicted permease, member of the PurR regulon [General function prediction only]; Region: yhhT; COG0628
195102005595	PRC-barrel domain containing protein [General function prediction only]; Region: COG3881
195102005596	PRC-barrel domain; Region: PRC; pfam05239
195102005597	Predicted tRNA(5-methylaminomethyl-2-thiouridylate) methyltransferase, contains the PP-loop ATPase domain [Translation, ribosomal structure and biogenesis]; Region: TrmU; COG0482
195102005598	tRNA methyl transferase. This family represents tRNA(5-methylaminomethyl-2-thiouridine)-methyltransferase which is involved in the biosynthesis of the modified nucleoside 5-methylaminomethyl-2-thiouridine present in the wobble position of some tRNAs; Region: tRNA_Me_trans; cd01998
195102005599	Ligand Binding Site [chemical binding]; other site
195102005600	NifU homolog involved in Fe-S cluster formation [Energy production and conversion]; Region: IscU; COG0822
195102005601	Iron-sulfur cluster scaffold-like proteins; Region: IscU_like; cd06664
195102005602	trimerization site [polypeptide binding]; other site
195102005603	active site
195102005604	Cysteine sulfinate desulfinase/cysteine desulfurase and related enzymes [Amino acid transport and metabolism]; Region: NifS; COG1104
195102005605	cysteine desulfurase NifS; Region: FeS_nifS; TIGR03402
195102005606	pyridoxal 5'-phosphate binding pocket [chemical binding]; other site
195102005607	catalytic residue [active]
195102005608	Predicted transcriptional regulator [Transcription]; Region: COG1959
195102005609	Transcriptional regulator; Region: Rrf2; cl17282
195102005610	recombination factor protein RarA; Reviewed; Region: PRK13342
195102005611	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
195102005612	Walker A motif; other site
195102005613	ATP binding site [chemical binding]; other site
195102005614	Walker B motif; other site
195102005615	arginine finger; other site
195102005616	MgsA AAA+ ATPase C terminal; Region: MgsA_C; pfam12002
195102005617	Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949
195102005618	metal binding site [ion binding]; metal-binding site
195102005619	active site
195102005620	I-site; other site
195102005621	MOSC domain; Region: MOSC; pfam03473
195102005622	molybdenum cofactor biosynthesis protein A, bacterial; Region: moaA; TIGR02666
195102005623	Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335
195102005624	FeS/SAM binding site; other site
195102005625	Molybdenum Cofactor Synthesis C; Region: Mob_synth_C; pfam06463
195102005626	MoeA_like. This domain is similar to a domain found in a variety of proteins involved in biosynthesis of molybdopterin cofactor, like MoaB, MogA, and MoeA. There this domain is presumed to bind molybdopterin. The exact function of this subgroup is...; Region: MoeA_like; cd03522
195102005627	putative MPT binding site; other site
195102005628	MobA catalyzes the formation of molybdopterin guanine dinucleotide; Region: MobA; cd02503
195102005629	GTP binding site; other site
195102005630	Molybdopterin biosynthesis enzyme [Coenzyme metabolism]; Region: MoeA; COG0303
195102005631	MoeA family. Members of this family are involved in biosynthesis of the molybdenum cofactor (MoCF), an essential cofactor of a diverse group of redox enzymes. MoCF biosynthesis is an evolutionarily conserved pathway present in eubacteria, archaea and...; Region: MoeA; cd00887
195102005632	dimer interface [polypeptide binding]; other site
195102005633	putative functional site; other site
195102005634	putative MPT binding site; other site
195102005635	Molybdenum is an essential trace element in the form of molybdenum cofactor (Moco) which is associated with the metabolism of nitrogen, carbon and sulfur by redox active enzymes. In E. coli, the synthesis of Moco involves genes from several loci: moa; Region: MobB; cd03116
195102005636	Walker A motif; other site
195102005637	Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox_2; pfam07992
195102005638	Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070
195102005639	DMSO reductase, iron-sulfur subunit; Region: DMSO_dmsB; TIGR02951
195102005640	Nitrate reductases, NapA (Nitrate-R-NapA), NasA, and NarB catalyze the reduction of nitrate to nitrite. Monomeric Nas is located in the cytoplasm and participates in nitrogen assimilation. Dimeric Nap is located in the periplasm and is coupled to quinol...; Region: MopB_Nitrate-R-NapA-like; cd02754
195102005641	formate dehydrogenase, alpha subunit, archaeal-type; Region: Fdh-alpha; TIGR01591
195102005642	[4Fe-4S] binding site [ion binding]; other site
195102005643	molybdopterin cofactor binding site; other site
195102005644	Nitrate reductases, NapA (Nitrate-R-NapA), NasA, and NarB catalyze the reduction of nitrate to nitrite. Monomeric Nas is located in the cytoplasm and participates in nitrogen assimilation. Dimeric Nap is located in the periplasm and is coupled to quinol...; Region: MopB_CT_Nitrate-R-NapA-like; cd02791
195102005645	molybdopterin cofactor binding site; other site
195102005646	Glucose inhibited division protein A; Region: GIDA; pfam01134
195102005647	Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070
195102005648	tRNA (uracil-5-)-methyltransferase Gid; Reviewed; Region: PRK05335
195102005649	hypothetical protein; Provisional; Region: PRK05802
195102005650	FAD/NAD binding domain (electron transfer subunit) of dihydroorotate dehydrogenase-like proteins. Dihydroorotate dehydrogenases (DHODs) catalyze the only redox reaction in pyrimidine de novo biosynthesis. They catalyze the oxidation of (S)-dihydroorotate...; Region: DHOD_e_trans_like; cd06192
195102005651	FAD binding pocket [chemical binding]; other site
195102005652	FAD binding motif [chemical binding]; other site
195102005653	phosphate binding motif [ion binding]; other site
195102005654	beta-alpha-beta structure motif; other site
195102005655	NAD binding pocket [chemical binding]; other site
195102005656	Iron coordination center [ion binding]; other site
195102005657	Beta-lactamase enzyme family; Region: Beta-lactamase2; cl17872
195102005658	D-alanyl-D-alanine carboxypeptidase; Region: Peptidase_S11; pfam00768
195102005659	Protein of unknown function (DUF2953); Region: DUF2953; pfam11167
195102005660	Sporulation protein YtfJ (Spore_YtfJ); Region: Spore_YtfJ; cl01596
195102005661	segregation and condensation protein B; Reviewed; Region: scpB; PRK00135
195102005662	segregation and condensation protein A; Reviewed; Region: scpA; PRK00104
195102005663	D-alanyl-D-alanine carboxypeptidase [Cell envelope biogenesis, outer membrane]; Region: DacC; COG1686
195102005664	Beta-lactamase enzyme family; Region: Beta-lactamase2; cl17872
195102005665	Penicillin-binding protein 5, C-terminal domain; Region: PBP5_C; pfam07943
195102005666	pyrimidine-nucleoside phosphorylase; Region: Y_phosphoryl; TIGR02644
195102005667	Glycosyl transferase family, helical bundle domain; Region: Glycos_trans_3N; pfam02885
195102005668	Glycosyl transferase family, a/b domain; Region: Glycos_transf_3; pfam00591
195102005669	Pyrimidine nucleoside phosphorylase C-terminal domain; Region: PYNP_C; pfam07831
195102005670	tyrosine recombinase XerD; Region: recomb_XerD; TIGR02225
195102005671	DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213
195102005672	active site
195102005673	DNA binding site [nucleotide binding]
195102005674	Int/Topo IB signature motif; other site
195102005675	stage II sporulation protein M; Region: spo_II_M; TIGR02831
195102005676	ADP-ribose pyrophosphatase (ADPRase) catalyzes the hydrolysis of ADP-ribose and a variety of additional ADP-sugar conjugates to AMP and ribose-5-phosphate. Like other members of the Nudix hydrolase superfamily, it requires a divalent cation, such as Mg2+; Region: ADPRase_NUDT5; cd03424
195102005677	dimer interface [polypeptide binding]; other site
195102005678	ADP-ribose binding site [chemical binding]; other site
195102005679	active site
195102005680	nudix motif; other site
195102005681	metal binding site [ion binding]; metal-binding site
195102005682	Sporulation initiation factor Spo0A C terminal; Region: Spo0A_C; pfam08769
195102005683	Response regulator receiver domain; Region: Response_reg; pfam00072
195102005684	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
195102005685	active site
195102005686	phosphorylation site [posttranslational modification]
195102005687	intermolecular recognition site; other site
195102005688	dimerization interface [polypeptide binding]; other site
195102005689	stage IV sporulation protein B; Region: spore_IV_B; TIGR02860
195102005690	PDZ domain of bacterial and plant zinc metalloprotases, presumably membrane-associated or integral membrane proteases, which may be involved in signalling and regulatory mechanisms. May be responsible for substrate recognition and/or binding, as most PDZ...; Region: PDZ_metalloprotease; cd00989
195102005691	SpoIVB peptidase S55; Region: Peptidase_S55; pfam05580
195102005692	ATPase involved in DNA repair [DNA replication, recombination, and repair]; Region: RecN; COG0497
195102005693	ATP-binding cassette domain of RecN; Region: ABC_RecN; cd03241
195102005694	Walker A/P-loop; other site
195102005695	ATP binding site [chemical binding]; other site
195102005696	Q-loop/lid; other site
195102005697	ATP-binding cassette domain of RecN; Region: ABC_RecN; cd03241
195102005698	ABC transporter signature motif; other site
195102005699	Walker B; other site
195102005700	D-loop; other site
195102005701	H-loop/switch region; other site
195102005702	arginine repressor; Provisional; Region: argR; PRK00441
195102005703	Arginine repressor, DNA binding domain; Region: Arg_repressor; pfam01316
195102005704	Arginine repressor, C-terminal domain; Region: Arg_repressor_C; pfam02863
195102005705	NAD kinase [Coenzyme metabolism]; Region: nadF; COG0061
195102005706	Predicted rRNA methylase [Translation, ribosomal structure and biogenesis]; Region: COG1189
195102005707	S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site;  Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165
195102005708	RNA binding surface [nucleotide binding]; other site
195102005709	FtsJ-like methyltransferase; Region: FtsJ; pfam01728
195102005710	1-deoxy-D-xylulose-5-phosphate synthase; Provisional; Region: PRK05444
195102005711	Thiamine pyrophosphate (TPP) family, DXS subfamily, TPP-binding module; 1-Deoxy-D-xylulose-5-phosphate synthase (DXS) is a regulatory enzyme of the mevalonate-independent pathway involved in terpenoid biosynthesis. Terpeniods are plant natural products...; Region: TPP_DXS; cd02007
195102005712	TPP-binding site; other site
195102005713	Pyrimidine (PYR) binding domain of 1-deoxy-D-xylulose-5-phosphate synthase (DXS), transketolase (TK), and related proteins; Region: TPP_PYR_DXS_TK_like; cd07033
195102005714	PYR/PP interface [polypeptide binding]; other site
195102005715	dimer interface [polypeptide binding]; other site
195102005716	TPP binding site [chemical binding]; other site
195102005717	Transketolase, C-terminal domain; Region: Transketolase_C; pfam02780
195102005718	Geranylgeranyl pyrophosphate synthase [Coenzyme metabolism]; Region: IspA; COG0142
195102005719	Trans-Isoprenyl Diphosphate Synthases, head-to-tail; Region: Trans_IPPS_HT; cd00685
195102005720	substrate binding pocket [chemical binding]; other site
195102005721	chain length determination region; other site
195102005722	substrate-Mg2+ binding site; other site
195102005723	catalytic residues [active]
195102005724	aspartate-rich region 1; other site
195102005725	active site lid residues [active]
195102005726	aspartate-rich region 2; other site
195102005727	exodeoxyribonuclease VII small subunit; Provisional; Region: PRK00977
195102005728	exodeoxyribonuclease VII large subunit; Reviewed; Region: xseA; PRK00286
195102005729	ExoVII_LU_OBF: A subfamily of OB folds corresponding to the N-terminal OB-fold domain of Escherichia coli exodeoxyribonuclease VII (ExoVII) large subunit. E. coli ExoVII is composed of two non-identical subunits. E. coli ExoVII is a...; Region: ExoVII_LU_OBF; cd04489
195102005730	generic binding surface I; other site
195102005731	generic binding surface II; other site
195102005732	bifunctional 5,10-methylene-tetrahydrofolate dehydrogenase/ 5,10-methylene-tetrahydrofolate cyclohydrolase; Provisional; Region: PRK14172
195102005733	Tetrahydrofolate dehydrogenase/cyclohydrolase, catalytic domain; Region: THF_DHG_CYH; pfam00763
195102005734	NADP binding domain of methylene-tetrahydrofolate dehydrogenase/cyclohydrolase; Region: NAD_bind_m-THF_DH_Cyclohyd; cd01080
195102005735	homodimer interface [polypeptide binding]; other site
195102005736	NADP binding site [chemical binding]; other site
195102005737	substrate binding site [chemical binding]; other site
195102005738	Transcription termination factor NusB (N protein-Utilization Substance B). NusB plays a key role in the regulation of ribosomal RNA biosynthesis in eubacteria by modulating the efficiency of transcriptional antitermination. NusB along with other Nus...; Region: Terminator_NusB; cd00619
195102005739	putative RNA binding site [nucleotide binding]; other site
195102005740	Asp23 family; Region: Asp23; pfam03780
195102005741	SpoIIIAH-like protein; Region: SpoIIIAH; pfam12685
195102005742	stage III sporulation protein AG; Region: spore_III_AG; TIGR02830
195102005743	Stage III sporulation protein AF (Spore_III_AF); Region: Spore_III_AF; cl17562
195102005744	stage III sporulation protein AE; Region: spore_III_AE; TIGR02829
195102005745	stage III sporulation protein AD; Region: spore_III_AD; TIGR02849
195102005746	stage III sporulation protein AC; Region: spore_III_AC; TIGR02848
195102005747	stage III sporulation protein AB; Region: spore_III_AB; TIGR02833
195102005748	stage III sporulation protein AA; Region: spore_III_AA; TIGR02858
195102005749	RecA-like NTPases. This family includes the NTP binding domain of F1 and V1 H+ATPases, DnaB and related helicases as well as bacterial RecA and related eukaryotic and archaeal recombinases. This group also includes bacterial conjugation proteins and...; Region: RecA-like_NTPases; cl17233
195102005750	Walker A motif; other site
195102005751	ATP binding site [chemical binding]; other site
195102005752	elongation factor P; Validated; Region: PRK00529
195102005753	Elongation factor P (EF-P) KOW-like domain; Region: EFP_N; pfam08207
195102005754	S1_EF-P_repeat_1: Translation elongation factor P (EF-P), S1-like RNA-binding domain, repeat 1. EF-P stimulates the peptidyltransferase activity in the prokaryotic 70S ribosome. EF-P enhances the synthesis of certain dipeptides with...; Region: S1_EF-P_repeat_1; cd04470
195102005755	RNA binding site [nucleotide binding]; other site
195102005756	S1_EF-P_repeat_2: Translation elongation factor P (EF-P), S1-like RNA-binding domain, repeat 1. EF-P stimulates the peptidyltransferase activity in the prokaryotic 70S ribosome. EF-P enhances the synthesis of certain dipeptides with...; Region: S1_EF-P_repeat_2; cd05794
195102005757	RNA binding site [nucleotide binding]; other site
195102005758	hypothetical protein; Provisional; Region: PRK10557
195102005759	Type II secretion system (T2SS), protein F; Region: T2SF; pfam00482
195102005760	Type II secretion system (T2SS), protein F; Region: T2SF; pfam00482
195102005761	Type II secretion system (T2SS), protein E, N-terminal domain; Region: T2SE_Nter; pfam05157
195102005762	Type II/IV secretion system protein; Region: T2SE; pfam00437
195102005763	RecA-like NTPases. This family includes the NTP binding domain of F1 and V1 H+ATPases, DnaB and related helicases as well as bacterial RecA and related eukaryotic and archaeal recombinases. This group also includes bacterial conjugation proteins and...; Region: RecA-like_NTPases; cl17233
195102005764	Walker A motif; other site
195102005765	ATP binding site [chemical binding]; other site
195102005766	Walker B motif; other site
195102005767	Dipeptidyl peptidase IV (DPP IV) N-terminal region; Region: DPPIV_N; pfam00930
195102005768	diaminopimelate epimerase; Provisional; Region: dapF; PRK00450
195102005769	Diaminopimelate epimerase; Region: DAP_epimerase; pfam01678
195102005770	Diaminopimelate epimerase; Region: DAP_epimerase; pfam01678
195102005771	Fibronectin-binding protein A N-terminus (FbpA); Region: FbpA; pfam05833
195102005772	Domain of unknown function (DUF814); Region: DUF814; pfam05670
195102005773	Predicted N6-adenine-specific DNA methylase [DNA replication, recombination, and repair]; Region: COG0116
195102005774	THUMP domain associated with S-adenosylmethionine-dependent methyltransferases; Region: THUMP_AdoMetMT; cd11715
195102005775	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl17173
195102005776	Pyrimidine operon attenuation protein/uracil phosphoribosyltransferase [Nucleotide transport and metabolism]; Region: PyrR; COG2065
195102005777	Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223
195102005778	active site
195102005779	Pseudouridylate synthases, 23S RNA-specific [Translation, ribosomal structure and biogenesis]; Region: RluA; COG0564
195102005780	S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site;  Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165
195102005781	RNA binding surface [nucleotide binding]; other site
195102005782	Pseudouridine synthase, RsuA/RluD family; Region: PseudoU_synth_RluCD_like; cd02869
195102005783	active site
195102005784	DivIVA protein; Region: DivIVA; pfam05103
195102005785	DivIVA domain; Region: DivI1A_domain; TIGR03544
195102005786	photosystem II S4 domain protein; Region: PS_II_S4; TIGR03069
195102005787	S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site;  Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165
195102005788	RNA binding surface [nucleotide binding]; other site
195102005789	Protein of unknown function (DUF552); Region: DUF552; cl00775
195102005790	Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzymes, YBL036c-like proteins; Region: PLPDE_III_YBL036c_like; cd00635
195102005791	pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site
195102005792	catalytic residue [active]
195102005793	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3879
195102005794	Bacterial protein of unknown function (DUF881); Region: DUF881; pfam05949
195102005795	Protein of unknown function (DUF1290); Region: DUF1290; pfam06947
195102005796	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3879
195102005797	Bacterial protein of unknown function (DUF881); Region: DUF881; pfam05949
195102005798	Cell division septal protein [Cell envelope biogenesis, outer membrane]; Region: FtsQ; COG1589
195102005799	POTRA domain, FtsQ-type; Region: POTRA_1; pfam08478
195102005800	Cell cycle protein; Region: FTSW_RODA_SPOVE; cl00511
195102005801	phospho-N-acetylmuramoyl-pentapeptide-transferase; Provisional; Region: mraY; PRK00108
195102005802	Phospho-N-acetylmuramoyl-pentapeptide-transferase (mraY) is an enzyme responsible for the formation of the first lipid intermediate in the synthesis of bacterial cell wall peptidoglycan. It catalyzes the formation of...; Region: GT_MraY; cd06852
195102005803	Mg++ binding site [ion binding]; other site
195102005804	putative catalytic motif [active]
195102005805	putative substrate binding site [chemical binding]; other site
195102005806	UDP-N-acetylmuramyl pentapeptide synthase [Cell envelope biogenesis, outer membrane]; Region: MurF; COG0770
195102005807	Mur ligase family, catalytic domain; Region: Mur_ligase; pfam01225
195102005808	Mur ligase middle domain; Region: Mur_ligase_M; pfam08245
195102005809	Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875
195102005810	UDP-N-acetylmuramoylalanyl-D-glutamate--2, 6-diaminopimelate ligase; Provisional; Region: murE; PRK00139
195102005811	Mur ligase family, catalytic domain; Region: Mur_ligase; pfam01225
195102005812	Mur ligase middle domain; Region: Mur_ligase_M; pfam08245
195102005813	Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875
195102005814	stage V sporulation protein D; Region: spoVD_pbp; TIGR02214
195102005815	Penicillin-binding Protein dimerisation domain; Region: PBP_dimer; pfam03717
195102005816	Penicillin binding protein transpeptidase domain; Region: Transpeptidase; pfam00905
195102005817	PASTA domain of PBP2x-like proteins, first repeat. Penicillin-binding proteins (PBPs) are the major targets for beta-lactam antibiotics, like penicillins and cephalosporins. Beta-lactam antibiotics specifically inhibit transpeptidase activity by...; Region: PASTA_Pbp2x-like_1; cd06576
195102005818	PASTA domain of PBP2x-like proteins, second repeat. Penicillin-binding proteins (PBPs) are the major targets for beta-lactam antibiotics, like penicillins and cephalosporins. Beta-lactam antibiotics specifically inhibit transpeptidase activity by...; Region: PASTA_Pbp2x-like_2; cd06575
195102005819	Cell division protein FtsL; Region: FtsL; cl11433
195102005820	MraW methylase family; Region: Methyltransf_5; pfam01795
195102005821	16S rRNA m(4)C1402 methyltranserfase; Provisional; Region: PRK00050
195102005822	GTP-binding protein YchF; Reviewed; Region: PRK09601
195102005823	YchF GTPase; Region: YchF; cd01900
195102005824	G1 box; other site
195102005825	GTP/Mg2+ binding site [chemical binding]; other site
195102005826	Switch I region; other site
195102005827	G2 box; other site
195102005828	Switch II region; other site
195102005829	G3 box; other site
195102005830	G4 box; other site
195102005831	G5 box; other site
195102005832	TGS_YchF_C: This subfamily represents TGS domain-containing YchF GTP-binding protein, a universally conserved GTPase whose function is unknown. The N-terminal domain of the YchF protein belongs to the Obg-like family of GTPases, and some members of the...; Region: TGS_YchF_C; cd04867
195102005833	Catalytic NodB homology domain of Bacillus subtilis polysaccharide deacetylase PdaA, and its bacterial homologs; Region: CE4_BsPdaA_like; cd10948
195102005834	delta-lactam-biosynthetic de-N-acetylase; Region: spore_pdaA; TIGR02884
195102005835	NodB motif; other site
195102005836	active site
195102005837	catalytic site [active]
195102005838	Cd binding site [ion binding]; other site
195102005839	Formiminotransferase-cyclodeaminase; Region: FTCD_C; pfam04961
195102005840	Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438
195102005841	Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013
195102005842	The glycosyltransferase WecG/TagA superfamily contains Escherichia coli WecG, Bacillus subtilis TagA and related proteins. E. coli WecG is believed to be a UDP-N-acetyl-D-mannosaminuronic acid transferase, and is involved in enterobacterial common...; Region: Glyco_transf_WecG_TagA; cd06533
195102005843	Tetratricopeptide repeat; Region: TPR_12; pfam13424
195102005844	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
195102005845	binding surface
195102005846	TPR motif; other site
195102005847	Phosphomannomutase [Carbohydrate transport and metabolism]; Region: {ManB}; COG1109
195102005848	This CD includes PGM2 (phosphoglucomutase 2) and PGM2L1 (phosphoglucomutase 2-like 1). The mammalian PGM2 is thought to be a phosphopentomutase that catalyzes the conversion of the nucleoside breakdown products, ribose-1-phosphate and...; Region: PGM2; cd05799
195102005849	active site
195102005850	substrate binding site [chemical binding]; other site
195102005851	metal binding site [ion binding]; metal-binding site
195102005852	50S ribosomal protein L25/general stress protein Ctc; Reviewed; Region: PRK05618
195102005853	Ribosomal L25/TL5/CTC N-terminal 5S rRNA binding domain; Region: Ribosomal_L25_TL5_CTC; cd00495
195102005854	5S rRNA interface [nucleotide binding]; other site
195102005855	CTC domain interface [polypeptide binding]; other site
195102005856	L16 interface [polypeptide binding]; other site
195102005857	Glycosyl hydrolase family 65 central catalytic domain; Region: Glyco_hydro_65m; pfam03632
195102005858	NPCBM/NEW2 domain; Region: NPCBM; pfam08305
195102005859	Cadherin-like beta sandwich domain; Region: Cadherin-like; pfam12733
195102005860	Concanavalin A-like lectin/glucanases superfamily; Region: Laminin_G_3; pfam13385
195102005861	Cadherin-like beta sandwich domain; Region: Cadherin-like; pfam12733
195102005862	Alpha-L-fucosidase [Carbohydrate transport and metabolism]; Region: COG3669
195102005863	Alpha-L-fucosidase; Region: Alpha_L_fucos; cl12119
195102005864	F5/8 type C domain; Region: F5_F8_type_C; pfam00754
195102005865	Calx-beta domain; Region: Calx-beta; pfam03160
195102005866	Glycerophosphodiester phosphodiesterase domain of Thermoanaerobacter tengcongensis and similar proteins; Region: GDPD_TtGDE_like; cd08563
195102005867	Glycerophosphoryl diester phosphodiesterase [Energy production and conversion]; Region: UgpQ; COG0584
195102005868	active site
195102005869	catalytic site [active]
195102005870	metal binding site [ion binding]; metal-binding site
195102005871	dimer interface [polypeptide binding]; other site
195102005872	Family of homologous FMN-dependent alpha-hydroxyacid oxidizing enzymes. This family occurs in both prokaryotes and eukaryotes. Members of this family include flavocytochrome b2 (FCB2), glycolate oxidase (GOX), lactate monooxygenase (LMO), mandelate...; Region: alpha_hydroxyacid_oxid_FMN; cd02809
195102005873	active site
195102005874	substrate binding site [chemical binding]; other site
195102005875	FMN-dependent dehydrogenase; Region: FMN_dh; pfam01070
195102005876	FMN binding site [chemical binding]; other site
195102005877	putative catalytic residues [active]
195102005878	Uncharacterized conserved protein [Function unknown]; Region: COG1683
195102005879	stage V sporulation protein D; Region: spoVD_pbp; TIGR02214
195102005880	Penicillin-binding Protein dimerisation domain; Region: PBP_dimer; pfam03717
195102005881	Penicillin binding protein transpeptidase domain; Region: Transpeptidase; pfam00905
195102005882	PASTA domain of PBP2x-like proteins, first repeat. Penicillin-binding proteins (PBPs) are the major targets for beta-lactam antibiotics, like penicillins and cephalosporins. Beta-lactam antibiotics specifically inhibit transpeptidase activity by...; Region: PASTA_Pbp2x-like_1; cd06576
195102005883	PASTA domain of PBP2x-like proteins, second repeat. Penicillin-binding proteins (PBPs) are the major targets for beta-lactam antibiotics, like penicillins and cephalosporins. Beta-lactam antibiotics specifically inhibit transpeptidase activity by...; Region: PASTA_Pbp2x-like_2; cd06575
195102005884	recombination and DNA strand exchange inhibitor protein; Reviewed; Region: PRK00409
195102005885	MutS domain III; Region: MutS_III; pfam05192
195102005886	ATP-binding cassette domain of MutS2; Region: ABC_MutS2; cd03280
195102005887	Walker A/P-loop; other site
195102005888	ATP binding site [chemical binding]; other site
195102005889	Q-loop/lid; other site
195102005890	ABC transporter signature motif; other site
195102005891	Walker B; other site
195102005892	D-loop; other site
195102005893	H-loop/switch region; other site
195102005894	Smr domain; Region: Smr; pfam01713
195102005895	Collagenase and related proteases [Posttranslational modification, protein turnover, chaperones]; Region: COG0826
195102005896	Peptidase family U32; Region: Peptidase_U32; pfam01136
195102005897	Collagenase; Region: DUF3656; pfam12392
195102005898	Peptidase family U32; Region: Peptidase_U32; cl03113
195102005899	histidinol-phosphatase; Provisional; Region: PRK05588
195102005900	Polymerase and Histidinol Phosphatase domain; Region: PHP; cl17102
195102005901	active site
195102005902	Cell division protein ZapA; Region: ZapA; pfam05164
195102005903	phenylalanyl-tRNA synthetase subunit beta; Reviewed; Region: pheT; PRK00629
195102005904	tRNA-binding-domain-containing prokaryotic phenylalanly tRNA synthetase (PheRS) beta chain.  PheRS aminoacylate phenylalanine transfer RNAs (tRNAphe). PheRSs belong structurally to class II aminoacyl tRNA synthetases (aaRSs) but, as they aminoacylate...; Region: tRNA_bind_bactPheRS; cd02796
195102005905	putative tRNA-binding site [nucleotide binding]; other site
195102005906	B3/4 domain; Region: B3_4; pfam03483
195102005907	tRNA synthetase B5 domain; Region: B5; smart00874
195102005908	Phenylalanyl-tRNA synthetase (PheRS) beta chain core domain. PheRS belongs to class II aminoacyl-tRNA synthetases (aaRS) based upon its structure. While class II aaRSs generally aminoacylate the 3'-OH ribose of the appropriate tRNA,  PheRS is an...; Region: PheRS_beta_core; cd00769
195102005909	dimer interface [polypeptide binding]; other site
195102005910	motif 1; other site
195102005911	motif 3; other site
195102005912	motif 2; other site
195102005913	Ferredoxin-fold anticodon binding domain; Region: FDX-ACB; smart00896
195102005914	phenylalanyl-tRNA synthetase subunit alpha; Validated; Region: pheS; PRK00488
195102005915	Aminoacyl tRNA synthetase class II, N-terminal domain; Region: Phe_tRNA-synt_N; pfam02912
195102005916	Phenylalanyl-tRNA synthetase (PheRS) alpha chain catalytic core domain. PheRS belongs to class II aminoacyl-tRNA synthetases (aaRS) based upon its structure and the presence of three characteristic sequence motifs. This domain is primarily responsible...; Region: PheRS_alpha_core; cd00496
195102005917	dimer interface [polypeptide binding]; other site
195102005918	motif 1; other site
195102005919	active site
195102005920	motif 2; other site
195102005921	motif 3; other site
195102005922	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG0675
195102005923	Helix-turn-helix domain; Region: HTH_OrfB_IS605; pfam12323
195102005924	Probable transposase; Region: OrfB_IS605; pfam01385
195102005925	transposase, IS605 OrfB family, central region; Region: tspaseT_teng_C; TIGR01766
195102005926	Transposase IS200 like; Region: Y1_Tnp; pfam01797
195102005927	rRNA methylases [Translation, ribosomal structure and biogenesis]; Region: SpoU; COG0566
195102005928	RNA 2'-O ribose methyltransferase substrate binding; Region: SpoU_sub_bind; smart00967
195102005929	SpoU rRNA Methylase family; Region: SpoU_methylase; pfam00588
195102005930	K+ transport systems, NAD-binding component [Inorganic ion transport and metabolism]; Region: TrkA; COG0569
195102005931	TrkA-N domain; Region: TrkA_N; pfam02254
195102005932	TrkA-C domain; Region: TrkA_C; pfam02080
195102005933	potassium uptake protein, TrkH family; Region: 2a38; TIGR00933
195102005934	Trk-type K+ transport systems, membrane components [Inorganic ion transport and metabolism]; Region: TrkG; COG0168
195102005935	Ribosomal protein L20; Region: Ribosomal_L20; cd07026
195102005936	23S rRNA binding site [nucleotide binding]; other site
195102005937	L21 binding site [polypeptide binding]; other site
195102005938	L13 binding site [polypeptide binding]; other site
195102005939	50S ribosomal protein L35; Reviewed; Region: rpmI; PRK00172
195102005940	translation initiation factor IF-3; Reviewed; Region: infC; PRK00028
195102005941	Translation initiation factor IF-3, N-terminal domain; Region: IF3_N; pfam05198
195102005942	Translation initiation factor IF-3, C-terminal domain; Region: IF3_C; pfam00707
195102005943	putative sporulation protein YtxC; Region: spo_ytxC; TIGR02834
195102005944	Transcriptional regulator/sugar kinase [Transcription / Carbohydrate transport and metabolism]; Region: NagC; COG1940
195102005945	Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cd00012
195102005946	nucleotide binding site [chemical binding]; other site
195102005947	ADP-ribose pyrophosphatase (ADPRase) catalyzes the hydrolysis of ADP-ribose and a variety of additional ADP-sugar conjugates to AMP and ribose-5-phosphate. Like other members of the Nudix hydrolase superfamily, it requires a divalent cation, such as Mg2+; Region: ADPRase_NUDT5; cd03424
195102005948	dimer interface [polypeptide binding]; other site
195102005949	ADP-ribose binding site [chemical binding]; other site
195102005950	active site
195102005951	nudix motif; other site
195102005952	metal binding site [ion binding]; metal-binding site
195102005953	Hsp33-like chaperonin; Reviewed; Region: hslO; PRK00114
195102005954	Heat shock protein 33 (Hsp33):  Cytosolic protein that acts as a molecular chaperone under oxidative conditions.  In normal (reducing) cytosolic conditions, four conserved Cys residues are coordinated by a Zn ion. Under oxidative stress (such as heat...; Region: Hsp33; cd00498
195102005955	dimerization interface [polypeptide binding]; other site
195102005956	domain crossover interface; other site
195102005957	redox-dependent activation switch; other site
195102005958	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
195102005959	S-adenosylmethionine binding site [chemical binding]; other site
195102005960	Small, acid-soluble spore proteins, alpha/beta type; Region: SASP; pfam00269
195102005961	aspartate-semialdehyde dehydrogenase; Provisional; Region: PRK14874
195102005962	Semialdehyde dehydrogenase, NAD binding domain; Region: Semialdhyde_dh; smart00859
195102005963	Dihydrodipicolinate synthase/N-acetylneuraminate lyase [Amino acid transport and metabolism / Cell envelope biogenesis, outer membrane]; Region: DapA; COG0329
195102005964	Dihydrodipicolinate synthase (DHDPS); Region: DHDPS; cd00950
195102005965	dimer interface [polypeptide binding]; other site
195102005966	active site
195102005967	catalytic residue [active]
195102005968	dihydrodipicolinate reductase; Provisional; Region: PRK00048
195102005969	Dihydrodipicolinate reductase, N-terminus; Region: DapB_N; pfam01113
195102005970	Dihydrodipicolinate reductase, C-terminus; Region: DapB_C; pfam05173
195102005971	aminotransferase A; Validated; Region: PRK07683
195102005972	Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609
195102005973	pyridoxal 5'-phosphate binding site [chemical binding]; other site
195102005974	homodimer interface [polypeptide binding]; other site
195102005975	catalytic residue [active]
195102005976	ATP:corrinoid adenosyltransferase BtuR/CobO/CobP. This family consists of the BtuR, CobO, CobP proteins all of which are Cob(I)alamin (vitamin B12) adenosyltransferase, which is involved in cobalamin (vitamin B12) biosynthesis. This enzyme is a homodimer; Region: CobA_CobO_BtuR; cd00561
195102005977	homodimer interface [polypeptide binding]; other site
195102005978	Walker A motif; other site
195102005979	ATP binding site [chemical binding]; other site
195102005980	hydroxycobalamin binding site [chemical binding]; other site
195102005981	Walker B motif; other site
195102005982	Tetrahydrodipicolinate succinyltransferase N-terminal; Region: DapH_N; pfam08503
195102005983	2,3,4,5-tetrahydropyridine-2,6-dicarboxylate N-acetyltransferase; Region: DapD_Ac; TIGR03532
195102005984	2,3,4,5-tetrahydropyridine-2,6-dicarboxylate (THDP) N-succinyltransferase (also called THP succinyltransferase): THDP N-succinyltransferase catalyzes the conversion of tetrahydrodipicolinate and succinyl-CoA to N-succinyltetrahydrodipicolinate and CoA; Region: LbH_THP_succinylT; cd03350
195102005985	active site
195102005986	trimer interface [polypeptide binding]; other site
195102005987	substrate binding site [chemical binding]; other site
195102005988	CoA binding site [chemical binding]; other site
195102005989	single-stranded DNA-binding protein; Provisional; Region: PRK05813
195102005990	SSB_OBF: A subfamily of OB folds similar to the OB fold of ssDNA-binding protein (SSB). SSBs bind with high affinity to ssDNA. They bind to and protect ssDNA intermediates during DNA metabolic pathways. All bacterial and eukaryotic SSBs studied to date...; Region: SSB_OBF; cd04496
195102005991	dimer interface [polypeptide binding]; other site
195102005992	ssDNA binding site [nucleotide binding]; other site
195102005993	tetramer (dimer of dimers) interface [polypeptide binding]; other site
195102005994	Catalytic NodB homology domain of rhizobial NodB-like proteins; Region: CE4_NodB_like_6s_7s; cd10917
195102005995	NodB motif; other site
195102005996	active site
195102005997	catalytic site [active]
195102005998	metal binding site [ion binding]; metal-binding site
195102005999	Domain of unknown function (DUF4364); Region: DUF4364; pfam14277
195102006000	Predicted permease, member of the PurR regulon [General function prediction only]; Region: yhhT; COG0628
195102006001	Domain of unknown function DUF20; Region: UPF0118; pfam01594
195102006002	Transcriptional regulator [Transcription]; Region: LytR; COG1316
195102006003	Haemolysin-III related; Region: HlyIII; cl03831
195102006004	channel protein, hemolysin III family; Region: hlyIII; TIGR01065
195102006005	Cupin superfamily (DUF985); Region: Cupin_5; pfam06172
195102006006	ClC chloride channel EriC.  This domain is found in the EriC chloride transporters that mediate the extreme acid resistance response in eubacteria and archaea. This response allows bacteria to survive in the acidic environments by decarboxylation-linked...; Region: EriC; cd01031
195102006007	Chloride channel protein EriC [Inorganic ion transport and metabolism]; Region: EriC; COG0038
195102006008	Cl- selectivity filter; other site
195102006009	Cl- binding residues [ion binding]; other site
195102006010	pore gating glutamate residue; other site
195102006011	dimer interface [polypeptide binding]; other site
195102006012	H+/Cl- coupling transport residue; other site
195102006013	TrkA-C domain; Region: TrkA_C; pfam02080
195102006014	Folylpolyglutamate synthase [Coenzyme metabolism]; Region: FolC; COG0285
195102006015	Mur ligase middle domain; Region: Mur_ligase_M; pfam08245
195102006016	Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875
195102006017	valyl-tRNA synthetase; Reviewed; Region: valS; PRK05729
195102006018	catalytic core domain of valyl-tRNA synthetases; Region: ValRS_core; cd00817
195102006019	HIGH motif; other site
195102006020	Leucyl-tRNA synthetase, Domain 2; Region: tRNA-synt_1_2; pfam13603
195102006021	catalytic core domain of valyl-tRNA synthetases; Region: ValRS_core; cd00817
195102006022	active site
195102006023	KMSKS motif; other site
195102006024	Anticodon-binding domain of valyl tRNA synthetases; Region: Anticodon_Ia_Val; cd07962
195102006025	tRNA binding surface [nucleotide binding]; other site
195102006026	anticodon binding site; other site
195102006027	Valyl tRNA synthetase tRNA binding arm; Region: Val_tRNA-synt_C; pfam10458
195102006028	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
195102006029	binding surface
195102006030	TPR repeat; Region: TPR_11; pfam13414
195102006031	TPR motif; other site
195102006032	Tetratricopeptide repeat; Region: TPR_12; pfam13424
195102006033	Transglutaminase-like enzymes, putative cysteine proteases [Amino acid transport and metabolism]; Region: COG1305
195102006034	Transglutaminase-like superfamily; Region: Transglut_core; pfam01841
195102006035	RecX family; Region: RecX; cl00936
195102006036	Predicted Zn-dependent peptidases [General function prediction only]; Region: PqqL; COG0612
195102006037	Insulinase (Peptidase family M16); Region: Peptidase_M16; pfam00675
195102006038	Peptidase M16 inactive domain; Region: Peptidase_M16_C; pfam05193
195102006039	Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745
195102006040	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
195102006041	active site
195102006042	phosphorylation site [posttranslational modification]
195102006043	intermolecular recognition site; other site
195102006044	dimerization interface [polypeptide binding]; other site
195102006045	Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383
195102006046	DNA binding site [nucleotide binding]
195102006047	Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642
195102006048	Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225
195102006049	dimerization interface [polypeptide binding]; other site
195102006050	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
195102006051	dimer interface [polypeptide binding]; other site
195102006052	phosphorylation site [posttranslational modification]
195102006053	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
195102006054	ATP binding site [chemical binding]; other site
195102006055	Mg2+ binding site [ion binding]; other site
195102006056	G-X-G motif; other site
195102006057	3-ketoacyl-(acyl-carrier-protein) reductase; Provisional; Region: fabG; PRK05565
195102006058	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
195102006059	NAD(P) binding site [chemical binding]; other site
195102006060	active site
195102006061	Zn-dependent dipeptidase, microsomal dipeptidase homolog [Amino acid transport and metabolism]; Region: COG2355
195102006062	renal dipeptidase (rDP), best studied in mammals and also called membrane or microsomal dipeptidase, is a membrane-bound glycoprotein hydrolyzing dipeptides and is involved in hydrolytic metabolism of penem and carbapenem beta-lactam antibiotics; Region: rDP_like; cd01301
195102006063	active site
195102006064	dimer interface [polypeptide binding]; other site
195102006065	serine hydroxymethyltransferase; Reviewed; Region: glyA; PRK00011
195102006066	Serine-glycine hydroxymethyltransferase (SHMT). This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). SHMT carries out interconversion of serine and glycine; it catalyzes the transfer of hydroxymethyl...; Region: SHMT; cd00378
195102006067	dimer interface [polypeptide binding]; other site
195102006068	active site
195102006069	glycine-pyridoxal phosphate binding site [chemical binding]; other site
195102006070	folate binding site [chemical binding]; other site
195102006071	Uncharacterized conserved protein [Function unknown]; Region: COG2966
195102006072	Protein of unknown function (DUF1212); Region: DUF1212; pfam06738
195102006073	Protein of unknown function (DUF3815); Region: DUF3815; pfam12821
195102006074	Transcriptional regulators CsoR (copper-sensitive operon repressor), RcnR, and FrmR, and related domains; this domain superfamily was previously known as DUF156; Region: CsoR-like_DUF156; cd10148
195102006075	putative homodimer interface [polypeptide binding]; other site
195102006076	putative homotetramer interface [polypeptide binding]; other site
195102006077	putative allosteric switch controlling residues; other site
195102006078	putative metal binding site [ion binding]; other site
195102006079	putative homodimer-homodimer interface [polypeptide binding]; other site
195102006080	aspartyl-tRNA synthetase; Validated; Region: aspS; PRK00476
195102006081	EcAspRS_like_N: N-terminal, anticodon recognition domain of the type found in Escherichia coli aspartyl-tRNA synthetase (AspRS), the human mitochondrial (mt) AspRS-2, the discriminating (D) Thermus thermophilus AspRS-1, and the nondiscriminating (ND)...; Region: EcAspRS_like_N; cd04317
195102006082	dimer interface [polypeptide binding]; other site
195102006083	anticodon binding site; other site
195102006084	Asp tRNA synthetase (aspRS) class II core domain. Class II assignment is based upon its structure and the presence of three characteristic sequence motifs. AspRS is a homodimer, which attaches a specific amino acid to the 3' OH group of ribose of...; Region: AspRS_core; cd00777
195102006085	homodimer interface [polypeptide binding]; other site
195102006086	motif 1; other site
195102006087	active site
195102006088	motif 2; other site
195102006089	GAD domain; Region: GAD; pfam02938
195102006090	Asp tRNA synthetase (aspRS) class II core domain. Class II assignment is based upon its structure and the presence of three characteristic sequence motifs. AspRS is a homodimer, which attaches a specific amino acid to the 3' OH group of ribose of...; Region: AspRS_core; cd00777
195102006091	motif 3; other site
195102006092	histidyl-tRNA synthetase; Region: hisS; TIGR00442
195102006093	Class II Histidinyl-tRNA synthetase (HisRS)-like catalytic core domain. HisRS is a homodimer. It is responsible for the attachment of histidine to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for...; Region: HisRS-like_core; cd00773
195102006094	dimer interface [polypeptide binding]; other site
195102006095	motif 1; other site
195102006096	active site
195102006097	motif 2; other site
195102006098	HisRS Histidyl-anticodon binding domain. HisRS belongs to class II aminoacyl-tRNA synthetases (aaRS). This alignment contains the anticodon binding domain, which is responsible for specificity in tRNA-binding, so that the activated amino acid is...; Region: HisRS_anticodon; cd00859
195102006099	anticodon binding site; other site
195102006100	coproporphyrinogen III oxidase; Provisional; Region: PRK08207
195102006101	Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335
195102006102	FeS/SAM binding site; other site
195102006103	Zn-dependent hydrolases, including glyoxylases [General function prediction only]; Region: GloB; COG0491
195102006104	D-Tyrosyl-tRNAtyr deacylases; a class of tRNA-dependent hydrolases which are capable of hydrolyzing the ester bond of D-Tyrosyl-tRNA reducing the level of cellular D-Tyrosine while recycling the peptidyl-tRNA; found in bacteria and in eukaryotes but not...; Region: Dtyr_deacylase; cd00563
195102006105	putative active site [active]
195102006106	dimerization interface [polypeptide binding]; other site
195102006107	putative tRNAtyr binding site [nucleotide binding]; other site
195102006108	Guanosine polyphosphate pyrophosphohydrolases/synthetases [Signal transduction mechanisms / Transcription]; Region: SpoT; COG0317
195102006109	Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077
195102006110	Zn2+ binding site [ion binding]; other site
195102006111	Mg2+ binding site [ion binding]; other site
195102006112	Nucleotidyltransferase (NT) domain of RelA- and SpoT-like ppGpp synthetases and hydrolases; Region: NT_Rel-Spo_like; cd05399
195102006113	synthetase active site [active]
195102006114	NTP binding site [chemical binding]; other site
195102006115	metal binding site [ion binding]; metal-binding site
195102006116	TGS_RelA_SpoT: The RelA (SpoT) protein, also referred to as ppGpp hydrolase/synthetase, is a ribosome-associated protein that is activated during amino acid starvation and thought to mediate the stringent response. RelA contains a TGS domain, named after...; Region: TGS_RelA_SpoT; cd01668
195102006117	ACT  domain found C-terminal of the RelA/SpoT domains; Region: ACT_RelA-SpoT; cd04876
195102006118	Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223
195102006119	active site
195102006120	DHH family; Region: DHH; pfam01368
195102006121	preprotein translocase subunit SecF; Reviewed; Region: secF; PRK13022
195102006122	SecD/SecF GG Motif; Region: Sec_GG; pfam07549
195102006123	Protein export membrane protein; Region: SecD_SecF; pfam02355
195102006124	protein-export membrane protein SecD; Region: secD; TIGR01129
195102006125	protein-export membrane protein, SecD/SecF family; Region: 2A0604s01; TIGR00916
195102006126	SCIFF radical SAM maturase; Region: rSAM_six_Cys; TIGR03974
195102006127	Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335
195102006128	FeS/SAM binding site; other site
195102006129	radical SAM additional 4Fe4S-binding SPASM domain; Region: rSAM_more_4Fe4S; TIGR04085
195102006130	preprotein translocase subunit YajC; Validated; Region: yajC; PRK05585
195102006131	queuine tRNA-ribosyltransferase; Provisional; Region: tgt; PRK00112
195102006132	Queuine/archaeosine tRNA-ribosyltransferase [Translation, ribosomal structure and biogenesis]; Region: Tgt; COG0343
195102006133	S-adenosylmethionine:tRNA ribosyltransferase-isomerase; Provisional; Region: queA; PRK00147
195102006134	S-adenosylmethionine:tRNA ribosyltransferase-isomerase; Region: queA; TIGR00113
195102006135	Holliday junction DNA helicase RuvB; Reviewed; Region: ruvB; PRK00080
195102006136	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
195102006137	Walker A motif; other site
195102006138	ATP binding site [chemical binding]; other site
195102006139	Walker B motif; other site
195102006140	arginine finger; other site
195102006141	Holliday junction DNA helicase ruvB C-terminus; Region: RuvB_C; pfam05491
195102006142	Holliday junction DNA helicase RuvA; Reviewed; Region: ruvA; PRK00116
195102006143	RuvA N terminal domain; Region: RuvA_N; pfam01330
195102006144	RuvA, C-terminal domain; Region: RuvA_C; pfam07499
195102006145	bifunctional 2',3'-cyclic nucleotide 2'-phosphodiesterase/3'-nucleotidase precursor protein; Reviewed; Region: PRK09419
195102006146	Escherichia coli CpdB and related proteins, N-terminal metallophosphatase domain; Region: MPP_CpdB_N; cd07410
195102006147	active site
195102006148	metal binding site [ion binding]; metal-binding site
195102006149	5'-nucleotidase, C-terminal domain; Region: 5_nucleotid_C; pfam02872
195102006150	Escherichia coli UshA-like family, N-terminal metallophosphatase domain; Region: MPP_UshA_N_like; cd00845
195102006151	active site
195102006152	metal binding site [ion binding]; metal-binding site
195102006153	5'-nucleotidase, C-terminal domain; Region: 5_nucleotid_C; pfam02872
195102006154	LPXTG-motif cell wall anchor domain; Region: LPXTG_anchor; TIGR01167
195102006155	bifunctional 2',3'-cyclic nucleotide 2'-phosphodiesterase/3'-nucleotidase precursor protein; Reviewed; Region: PRK09419
195102006156	Escherichia coli CpdB and related proteins, N-terminal metallophosphatase domain; Region: MPP_CpdB_N; cd07410
195102006157	active site
195102006158	metal binding site [ion binding]; metal-binding site
195102006159	5'-nucleotidase, C-terminal domain; Region: 5_nucleotid_C; pfam02872
195102006160	Escherichia coli UshA-like family, N-terminal metallophosphatase domain; Region: MPP_UshA_N_like; cd00845
195102006161	active site
195102006162	metal binding site [ion binding]; metal-binding site
195102006163	5'-nucleotidase, C-terminal domain; Region: 5_nucleotid_C; pfam02872
195102006164	Tyrosine phosphatase family; Region: Y_phosphatase3; pfam13350
195102006165	Tyrosine phosphatase family C-terminal region; Region: Y_phosphatase3C; pfam13348
195102006166	Globins are heme proteins, which bind and transport oxygen. This family summarizes a diverse set of homologous protein domains, including: (1) tetrameric vertebrate hemoglobins, which are the major protein component of erythrocytes and transport oxygen...; Region: globin; cd01040
195102006167	heme-binding site [chemical binding]; other site
195102006168	hypothetical protein; Validated; Region: PRK00110
195102006169	Uncharacterized conserved protein [Function unknown]; Region: COG1739
195102006170	Uncharacterized protein family UPF0029; Region: UPF0029; pfam01205
195102006171	Domain of unknown function (DUF1949); Region: DUF1949; pfam09186
195102006172	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain (MocR family) and their eukaryotic orthologs [Transcription / Amino acid transport and metabolism]; Region: ARO8; COG1167
195102006173	Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377
195102006174	DNA-binding site [nucleotide binding]; DNA binding site
195102006175	Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609
195102006176	pyridoxal 5'-phosphate binding site [chemical binding]; other site
195102006177	homodimer interface [polypeptide binding]; other site
195102006178	catalytic residue [active]
195102006179	Nucleotidyltransferase (NT) domain of Staphylococcus aureus kanamycin nucleotidyltransferase, and similar proteins; Region: NT_KNTase_like; cd05403
195102006180	active site
195102006181	NTP binding site [chemical binding]; other site
195102006182	metal binding triad [ion binding]; metal-binding site
195102006183	antibiotic binding site [chemical binding]; other site
195102006184	GTP-binding protein HflX; Region: GTP_HflX; TIGR03156
195102006185	GTP-binding GTPase N-terminal; Region: GTP-bdg_N; pfam13167
195102006186	HflX GTPase family; Region: HflX; cd01878
195102006187	G1 box; other site
195102006188	GTP/Mg2+ binding site [chemical binding]; other site
195102006189	Switch I region; other site
195102006190	G2 box; other site
195102006191	G3 box; other site
195102006192	Switch II region; other site
195102006193	G4 box; other site
195102006194	G5 box; other site
195102006195	Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223
195102006196	active site
195102006197	sporulation protein YunB; Region: spo_yunB; TIGR02832
195102006198	Transglycosylase; Region: Transgly; pfam00912
195102006199	penicillin-binding protein, 1A family; Region: PBP_1a_fam; TIGR02074
195102006200	Penicillin binding protein transpeptidase domain; Region: Transpeptidase; cl17760
195102006201	Na+/alanine symporter [Amino acid transport and metabolism]; Region: AlsT; COG1115
195102006202	amino acid carrier protein; Region: agcS; TIGR00835
195102006203	Acetyltransferase (GNAT) domain; Region: Acetyltransf_3; pfam13302
195102006204	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301
195102006205	Coenzyme A binding pocket [chemical binding]; other site
195102006206	DNA-binding transcriptional repressor PuuR; Provisional; Region: PRK09943
195102006207	Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093
195102006208	non-specific DNA binding site [nucleotide binding]; other site
195102006209	salt bridge; other site
195102006210	sequence-specific DNA binding site [nucleotide binding]; other site
195102006211	Cupin domain; Region: Cupin_2; pfam07883
195102006212	ABC-type spermidine/putrescine transport systems, ATPase components [Amino acid transport and metabolism]; Region: PotA; COG3842
195102006213	ATP-binding cassette domain of the polyamine transporter; Region: ABC_PotA_N; cd03300
195102006214	Walker A/P-loop; other site
195102006215	ATP binding site [chemical binding]; other site
195102006216	Q-loop/lid; other site
195102006217	ABC transporter signature motif; other site
195102006218	Walker B; other site
195102006219	D-loop; other site
195102006220	H-loop/switch region; other site
195102006221	TOBE domain; Region: TOBE_2; pfam08402
195102006222	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
195102006223	dimer interface [polypeptide binding]; other site
195102006224	conserved gate region; other site
195102006225	putative PBP binding loops; other site
195102006226	ABC-ATPase subunit interface; other site
195102006227	ABC-type spermidine/putrescine transport system, permease component II [Amino acid transport and metabolism]; Region: PotC; COG1177
195102006228	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
195102006229	dimer interface [polypeptide binding]; other site
195102006230	conserved gate region; other site
195102006231	putative PBP binding loops; other site
195102006232	ABC-ATPase subunit interface; other site
195102006233	Spermidine/putrescine-binding periplasmic protein [Amino acid transport and metabolism]; Region: PotD; COG0687
195102006234	Bacterial extracellular solute-binding protein; Region: SBP_bac_6; pfam13343
195102006235	Nucleoside diphosphate kinase Group I (NDPk_I)-like: NDP kinase domains are present in a large family of structurally and functionally conserved proteins from bacteria to humans that generally catalyze the transfer of gamma-phosphates of a nucleoside...; Region: NDPk_I; cd04413
195102006236	active site
195102006237	multimer interface [polypeptide binding]; other site
195102006238	Acylphosphatase; Region: Acylphosphatase; pfam00708
195102006239	D-alanyl-D-alanine carboxypeptidase; Region: Peptidase_S11; pfam00768
195102006240	Beta-lactamase enzyme family; Region: Beta-lactamase2; cl17872
195102006241	pyrophosphatase PpaX; Provisional; Region: PRK13288
195102006242	Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427
195102006243	active site
195102006244	motif I; other site
195102006245	motif II; other site
195102006246	Asparagine synthetase (aspartate-ammonia ligase) (AsnA) catalyses the conversion of L-aspartate to L-asparagine in the presence of ATP and ammonia.  AsnA is a homodimeric enzyme which is structurally similiar to the catalytic core domain of class II...; Region: AsnA; cd00645
195102006247	dimer interface [polypeptide binding]; other site
195102006248	active site
195102006249	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
195102006250	TPR motif; other site
195102006251	binding surface
195102006252	Putative effector of murein hydrolase LrgA [General function prediction only]; Region: COG1380
195102006253	LrgB-like family; Region: LrgB; pfam04172
195102006254	DNA topoisomerase III; Provisional; Region: PRK07726
195102006255	TOPRIM_TopoIA_TopoIII: The topoisomerase-primase (TORPIM) domain found in members of the type IA family of DNA topoisomerases (Topo IA) similar to topoisomerase III. Type IA DNA topoisomerases remove (relax) negative supercoils in the DNA by: cleaving...; Region: TOPRIM_TopoIA_TopoIII; cd03362
195102006256	active site
195102006257	putative interdomain interaction site [polypeptide binding]; other site
195102006258	putative metal-binding site [ion binding]; other site
195102006259	putative nucleotide binding site [chemical binding]; other site
195102006260	DNA Topoisomerase, subtype IA; DNA-binding, ATP-binding and catalytic domain of bacterial DNA topoisomerases I and III, and eukaryotic DNA topoisomerase III and eubacterial and archael reverse gyrases. Topoisomerases clevage single or double stranded DNA...; Region: TOP1Ac; cl11986
195102006261	domain I; other site
195102006262	DNA binding groove [nucleotide binding]
195102006263	phosphate binding site [ion binding]; other site
195102006264	domain II; other site
195102006265	domain III; other site
195102006266	nucleotide binding site [chemical binding]; other site
195102006267	catalytic site [active]
195102006268	domain IV; other site
195102006269	C-terminal repeat of topoisomerase; Region: Toprim_Crpt; pfam13342
195102006270	Imidazolonepropionase and related amidohydrolases [Secondary metabolites biosynthesis, transport, and catabolism]; Region: HutI; COG1228
195102006271	Metallo-dependent hydrolases, subgroup C is part of the superfamily of metallo-dependent hydrolases, a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the...; Region: Met_dep_hydrolase_C; cd01309
195102006272	active site
195102006273	TspO/MBR family; Region: TspO_MBR; pfam03073
195102006274	Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642
195102006275	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
195102006276	dimer interface [polypeptide binding]; other site
195102006277	phosphorylation site [posttranslational modification]
195102006278	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
195102006279	ATP binding site [chemical binding]; other site
195102006280	Mg2+ binding site [ion binding]; other site
195102006281	G-X-G motif; other site
195102006282	phosphate regulon sensor kinase PhoR; Region: phoR_proteo; TIGR02966
195102006283	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
195102006284	dimer interface [polypeptide binding]; other site
195102006285	phosphorylation site [posttranslational modification]
195102006286	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
195102006287	ATP binding site [chemical binding]; other site
195102006288	Mg2+ binding site [ion binding]; other site
195102006289	G-X-G motif; other site
195102006290	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
195102006291	binding surface
195102006292	TPR motif; other site
195102006293	TPR repeat; Region: TPR_11; pfam13414
195102006294	Tetratricopeptide repeat; Region: TPR_12; pfam13424
195102006295	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
195102006296	binding surface
195102006297	TPR motif; other site
195102006298	TPR repeat; Region: TPR_11; pfam13414
195102006299	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cl02429
195102006300	binding surface
195102006301	TPR motif; other site
195102006302	Lysophospholipase [Lipid metabolism]; Region: PldB; COG2267
195102006303	Putative lysophospholipase; Region: Hydrolase_4; pfam12146
195102006304	Protein Kinases, catalytic domain; Region: PKc_like; cl09925
195102006305	active site
195102006306	ATP binding site [chemical binding]; other site
195102006307	substrate binding site [chemical binding]; other site
195102006308	Glycosyl hydrolases family 8; Region: Glyco_hydro_8; cl01351
195102006309	Soluble lytic murein transglycosylase and related regulatory proteins (some contain LysM/invasin domains) [Cell envelope biogenesis, outer membrane]; Region: MltE; COG0741
195102006310	Lytic Transglycosylase (LT)  and Goose Egg White Lysozyme (GEWL) domain. Members include the soluble and insoluble membrane-bound LTs in bacteria, the LTs in bacteriophage lambda, as well as, the eukaryotic "goose-type" lysozymes (GEWL).  LTs...; Region: LT_GEWL; cd00254
195102006311	N-acetyl-D-glucosamine binding site [chemical binding]; other site
195102006312	catalytic residue [active]
195102006313	Dephospho-CoA kinase [Coenzyme metabolism]; Region: CoaE; COG0237
195102006314	Dephospho-coenzyme A kinase (DPCK, EC 2.7.1.24) catalyzes the phosphorylation of dephosphocoenzyme A (dCoA) to yield CoA, which is the final step in CoA biosynthesis; Region: DPCK; cd02022
195102006315	CoA-binding site [chemical binding]; other site
195102006316	ATP-binding [chemical binding]; other site
195102006317	DNA polymerase I; Provisional; Region: PRK05755
195102006318	PIN domain of the 5'-3' exonuclease of Taq DNA polymerase I and homologs; Region: PIN_53EXO; cd09859
195102006319	active site
195102006320	metal binding site 1 [ion binding]; metal-binding site
195102006321	putative 5' ssDNA interaction site; other site
195102006322	metal binding site 3; metal-binding site
195102006323	metal binding site 2 [ion binding]; metal-binding site
195102006324	H3TH domain of the 5'-3' exonuclease of Taq DNA polymerase I and homologs; Region: H3TH_53EXO; cd09898
195102006325	putative DNA binding site [nucleotide binding]; other site
195102006326	putative metal binding site [ion binding]; other site
195102006327	inactive DEDDy 3'-5' exonuclease domain of Bacillus stearothermophilus DNA polymerase I and similar family-A DNA polymerases; Region: DNA_polA_I_Bacillus_like_exo; cd06140
195102006328	Polymerase I functions primarily to fill DNA gaps that arise during DNA repair, recombination and replication; Region: DNA_pol_A_pol_I_C; cd08637
195102006329	active site
195102006330	DNA binding site [nucleotide binding]
195102006331	catalytic site [active]
195102006332	glutaminase A; Region: Gln_ase; TIGR03814
195102006333	Glutaminase [Amino acid transport and metabolism]; Region: GlsA; COG2066
195102006334	Thermophilic metalloprotease (M29); Region: Peptidase_M29; pfam02073
195102006335	Leucyl aminopeptidase (aminopeptidase T) [Amino acid transport and metabolism]; Region: AmpS; COG2309
195102006336	Predicted periplasmic protein (DUF2233); Region: DUF2233; pfam09992
195102006337	Elongator protein 3, MiaB family, Radical SAM; Region: Elp3; smart00729
195102006338	Protein of unknown function (DUF3816); Region: DUF3816; pfam12822
195102006339	NH_3: A subgroup of nucleoside hydrolases. This group contains eukaryotic and bacterial proteins similar to nucleoside hydrolases. Nucleoside hydrolases cleave the N-glycosidic bond in nucleosides generating ribose and the respective base. These enzymes...; Region: nuc_hydro_3; cd02653
195102006340	active site
195102006341	Uncharacterized conserved protein [Function unknown]; Region: COG0327
195102006342	NIF3 (NGG1p interacting factor 3); Region: NIF3; pfam01784
195102006343	Predicted SAM-dependent methyltransferase [General function prediction only]; Region: COG2384
195102006344	Family of unknown function (DUF633); Region: DUF633; pfam04816
195102006345	Protein of unknown function (DUF2679); Region: DUF2679; pfam10882
195102006346	RNA polymerase sigma factor RpoD; Validated; Region: PRK09210
195102006347	Sigma-70 factor, region 1.1; Region: Sigma70_r1_1; pfam03979
195102006348	Sigma-70 factor, region 1.2; Region: Sigma70_r1_2; pfam00140
195102006349	Sigma-70 region 2; Region: Sigma70_r2; pfam04542
195102006350	Sigma-70 region 3; Region: Sigma70_r3; pfam04539
195102006351	Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171
195102006352	DNA binding residues [nucleotide binding]
195102006353	DNA primase; Validated; Region: dnaG; PRK05667
195102006354	CHC2 zinc finger; Region: zf-CHC2; pfam01807
195102006355	DNA primase catalytic core, N-terminal domain; Region: Toprim_N; pfam08275
195102006356	TOPRIM_DnaG_primases: The topoisomerase-primase (TORPIM) nucleotidyl transferase/hydrolase domain found in the active site regions of proteins similar to Escherichia coli DnaG. Primases synthesize RNA primers for the initiation of DNA replication. DnaG...; Region: TOPRIM_DnaG_primases; cd03364
195102006357	active site
195102006358	metal binding site [ion binding]; metal-binding site
195102006359	interdomain interaction site; other site
195102006360	DnaB-helicase binding domain of primase; Region: DnaB_bind; pfam10410
195102006361	deoxyguanosinetriphosphate triphosphohydrolase-like protein; Provisional; Region: PRK01286
195102006362	Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077
195102006363	Zn2+ binding site [ion binding]; other site
195102006364	Mg2+ binding site [ion binding]; other site
195102006365	Phosphohydrolase-associated domain; Region: HD_assoc; pfam13286
195102006366	spore coat protein, CotS family; Region: spore_CotS; TIGR02906
195102006367	Aminoglycoside 3'-phosphotransferase (APH) and Choline Kinase (ChoK) family. The APH/ChoK family is part of a larger superfamily that includes the catalytic domains of other kinases, such as the typical serine/threonine/tyrosine protein kinases (PKs)...; Region: APH_ChoK_like; cd05120
195102006368	substrate binding site [chemical binding]; other site
195102006369	pyruvate phosphate dikinase; Provisional; Region: PRK09279
195102006370	Pyruvate phosphate dikinase, PEP/pyruvate binding domain; Region: PPDK_N; pfam01326
195102006371	PEP-utilising enzyme, mobile domain; Region: PEP-utilizers; pfam00391
195102006372	PEP-utilising enzyme, TIM barrel domain; Region: PEP-utilizers_C; pfam02896
195102006373	HTH domain; Region: HTH_11; pfam08279
195102006374	FOG: CBS domain [General function prediction only]; Region: COG0517
195102006375	The CBS domain, named after human CBS, is a small domain originally identified in cystathionine beta-synthase and is subsequently found in a wide range of different proteins. CBS domains usually occur in tandem repeats. They associate to form a so-called...; Region: CBS_pair_4; cd04617
195102006376	Domain of unknown function (DUF4342); Region: DUF4342; pfam14242
195102006377	Recombination protein O N terminal; Region: RecO_N; pfam11967
195102006378	DNA repair protein RecO; Region: reco; TIGR00613
195102006379	Recombination protein O C terminal; Region: RecO_C; pfam02565
195102006380	GTPase Era; Reviewed; Region: era; PRK00089
195102006381	E. coli Ras-like protein (Era) is a multifunctional GTPase; Region: Era; cd04163
195102006382	G1 box; other site
195102006383	GTP/Mg2+ binding site [chemical binding]; other site
195102006384	Switch I region; other site
195102006385	G2 box; other site
195102006386	Switch II region; other site
195102006387	G3 box; other site
195102006388	G4 box; other site
195102006389	G5 box; other site
195102006390	KH domain; Region: KH_2; pfam07650
195102006391	Cytidine deaminase zinc-binding domain. These enzymes are Zn dependent. The zinc ion in the active site plays a central role in the proposed catalytic mechanism, activating a water molecule to form a hydroxide ion that performs a nucleophilic attack on...; Region: cytidine_deaminase; cd01283
195102006392	active site
195102006393	catalytic motif [active]
195102006394	Zn binding site [ion binding]; other site
195102006395	Prokaryotic diacylglycerol kinase; Region: DAGK_prokar; pfam01219
195102006396	PAP2_like proteins, diacylglycerol_kinase like sub-family. In some prokaryotes, PAP2_like phosphatase domains appear fused to E. coli DAGK-like trans-membrane diacylglycerol kinase domains. The cellular function of these architectures remains to be...; Region: PAP2_diacylglycerolkinase; cd03383
195102006397	active site
195102006398	metal-binding heat shock protein; Provisional; Region: PRK00016
195102006399	Predicted membrane-associated HD superfamily hydrolase [General function prediction only]; Region: COG1480
195102006400	7TM receptor with intracellular HD hydrolase; Region: 7TM-7TMR_HD; pfam07698
195102006401	Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077
195102006402	Zn2+ binding site [ion binding]; other site
195102006403	Mg2+ binding site [ion binding]; other site
195102006404	Putative stage IV sporulation protein YqfD; Region: YqfD; pfam06898
195102006405	sporulation protein YqfD; Region: spore_yqfD; TIGR02876
195102006406	sporulation protein YqfC; Region: spore_yqfC; TIGR02856
195102006407	Yqey-like protein; Region: YqeY; pfam09424
195102006408	30S ribosomal protein S21; Reviewed; Region: rpsU; PRK00270
195102006409	Protein Kinase C Interacting protein related (PKCI): PKCI and related proteins belong to the ubiquitous HIT family of hydrolases that act on alpha-phosphates of ribonucleotides. The members of this subgroup have a conserved HxHxHxx motif (x is a...; Region: PKCI_related; cd01276
195102006410	nucleotide binding site/active site [active]
195102006411	HIT family signature motif; other site
195102006412	catalytic residue [active]
195102006413	2-methylthioadenine synthetase [Translation, ribosomal structure and biogenesis]; Region: MiaB; COG0621
195102006414	Uncharacterized protein family UPF0004; Region: UPF0004; pfam00919
195102006415	Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335
195102006416	FeS/SAM binding site; other site
195102006417	16S ribosomal RNA methyltransferase RsmE; Provisional; Region: PRK11713
195102006418	RNA methyltransferase, RsmE family; Region: TIGR00046
195102006419	Ribosomal protein L11 methyltransferase (PrmA); Region: PrmA; pfam06325
195102006420	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
195102006421	S-adenosylmethionine binding site [chemical binding]; other site
195102006422	Predicted transcriptional regulators [Transcription]; Region: COG1725
195102006423	Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377
195102006424	DNA-binding site [nucleotide binding]; DNA binding site
195102006425	ABC-type Mn/Zn transport systems, ATPase component [Inorganic ion transport and metabolism]; Region: ZnuC; COG1121
195102006426	ATP-binding cassette domain of the drug resistance transporter and related proteins, subfamily A; Region: ABC_DR_subfamily_A; cd03230
195102006427	Walker A/P-loop; other site
195102006428	ATP binding site [chemical binding]; other site
195102006429	Q-loop/lid; other site
195102006430	ABC transporter signature motif; other site
195102006431	Walker B; other site
195102006432	D-loop; other site
195102006433	H-loop/switch region; other site
195102006434	chaperone protein DnaJ; Provisional; Region: PRK14297
195102006435	DnaJ domain or J-domain.  DnaJ/Hsp40 (heat shock protein 40) proteins are highly conserved and play crucial roles in protein translation, folding, unfolding, translocation, and degradation. They act primarily by stimulating the ATPase activity of Hsp70s; Region: DnaJ; cd06257
195102006436	HSP70 interaction site [polypeptide binding]; other site
195102006437	C-terminal substrate binding domain of DnaJ and HSP40; Region: DnaJ_C; cl03262
195102006438	substrate binding site [polypeptide binding]; other site
195102006439	Zinc finger domain of DnaJ and HSP40; Region: DnaJ_zf; cd10719
195102006440	Zn binding sites [ion binding]; other site
195102006441	C-terminal substrate binding domain of DnaJ and HSP40; Region: DnaJ_C; cd10747
195102006442	dimer interface [polypeptide binding]; other site
195102006443	molecular chaperone DnaK; Provisional; Region: dnaK; PRK00290
195102006444	Nucleotide-binding domain of human HSPA9 and similar proteins; Region: HSPA9-Ssq1-like_NBD; cd10234
195102006445	nucleotide binding site [chemical binding]; other site
195102006446	NEF interaction site [polypeptide binding]; other site
195102006447	SBD interface [polypeptide binding]; other site
195102006448	GrpE; Region: GrpE; pfam01025
195102006449	GrpE is the adenine nucleotide exchange factor of DnaK (Hsp70)-type ATPases. The GrpE dimer binds to the ATPase domain of Hsp70 catalyzing the dissociation of ADP, which enables rebinding of ATP, one step in the Hsp70 reaction cycle in protein folding; Region: GrpE; cd00446
195102006450	dimer interface [polypeptide binding]; other site
195102006451	hsp70 (ATPase domain) interactions [polypeptide binding]; other site
195102006452	heat-inducible transcription repressor; Provisional; Region: hrcA; PRK00082
195102006453	Winged helix-turn-helix transcription repressor, HrcA DNA-binding; Region: HrcA_DNA-bdg; pfam03444
195102006454	coproporphyrinogen III oxidase; Provisional; Region: PRK05799
195102006455	Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335
195102006456	FeS/SAM binding site; other site
195102006457	HemN C-terminal domain; Region: HemN_C; pfam06969
195102006458	Ribosomal L25/TL5/CTC N-terminal 5S rRNA binding domain; Region: Ribosomal_L25_TL5_CTC; cd00495
195102006459	5S rRNA interface [nucleotide binding]; other site
195102006460	CTC domain interface [polypeptide binding]; other site
195102006461	L16 interface [polypeptide binding]; other site
195102006462	GTP-binding protein LepA; Provisional; Region: PRK05433
195102006463	LepA also known as Elongation Factor 4 (EF4); Region: LepA; cd01890
195102006464	G1 box; other site
195102006465	putative GEF interaction site [polypeptide binding]; other site
195102006466	GTP/Mg2+ binding site [chemical binding]; other site
195102006467	Switch I region; other site
195102006468	G2 box; other site
195102006469	G3 box; other site
195102006470	Switch II region; other site
195102006471	G4 box; other site
195102006472	G5 box; other site
195102006473	lepA_II: This subfamily represents the domain II of LepA, a GTP-binding protein localized in the cytoplasmic membrane. The N-terminal domain of LepA shares regions of homology to translation factors. In terms of interaction with the ribosome, EF-G, EF-Tu...; Region: lepA_II; cd03699
195102006474	lepA_C: This family represents the C-terminal region of LepA, a GTP-binding protein localized in the cytoplasmic membrane.   LepA is ubiquitous in Bacteria and Eukaryota (e.g. Saccharomyces cerevisiae GUF1p), but is missing from Archaea. LepA exhibits...; Region: lepA_C; cd03709
195102006475	GTP-binding protein LepA C-terminus; Region: LepA_C; pfam06421
195102006476	Stage II sporulation protein P (SpoIIP); Region: SpoIIP; pfam07454
195102006477	stage II sporulation protein P; Region: spore_II_P; TIGR02867
195102006478	germination protease; Provisional; Region: PRK12362
195102006479	30S ribosomal protein S20; Reviewed; Region: rpsT; PRK00239
195102006480	DNA polymerase III subunit delta; Reviewed; Region: holA; PRK05574
195102006481	DNA polymerase III, delta subunit; Region: DNA_pol3_delta; pfam06144
195102006482	DNA polymerase III subunits gamma and tau domain III; Region: DNA_pol3_gamma3; pfam12169
195102006483	Competence protein; Region: Competence; pfam03772
195102006484	stage V sporulation protein AE; Region: spore_V_AE; TIGR02839
195102006485	stage V sporulation protein AD; Validated; Region: PRK08304
195102006486	stage V sporulation protein AD; Provisional; Region: PRK12404
195102006487	stage V sporulation protein AC; Region: spore_V_AC; TIGR02838
195102006488	sporulation sigma factor SigF; Validated; Region: PRK05572
195102006489	Sigma-70 region 2; Region: Sigma70_r2; pfam04542
195102006490	Sigma-70 region 3; Region: Sigma70_r3; pfam04539
195102006491	Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171
195102006492	DNA binding residues [nucleotide binding]
195102006493	Histidine kinase-like ATPase domain; Region: HATPase_c_2; pfam13581
195102006494	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
195102006495	ATP binding site [chemical binding]; other site
195102006496	Mg2+ binding site [ion binding]; other site
195102006497	G-X-G motif; other site
195102006498	Sulphate Transporter and Anti-Sigma factor antagonist) domain of anti-anti-sigma factors, key regulators of anti-sigma factors by phosphorylation; Region: STAS_anti-anti-sigma_factors; cd07043
195102006499	Sulfate permease and related transporters (MFS superfamily) [Inorganic ion transport and metabolism]; Region: SUL1; COG0659
195102006500	anti sigma factor interaction site; other site
195102006501	regulatory phosphorylation site [posttranslational modification]; other site
195102006502	AAA domain; Region: AAA_32; pfam13654
195102006503	Predicted ATP-dependent protease [Posttranslational modification, protein turnover, chaperones]; Region: LonB; COG1067
195102006504	Lon protease (S16) C-terminal proteolytic domain; Region: Lon_C; pfam05362
195102006505	2-deoxyribose-5-phosphate aldolase (DERA) of the DeoC family; Region: DeoC; cd00959
195102006506	intersubunit interface [polypeptide binding]; other site
195102006507	active site
195102006508	catalytic residue [active]
195102006509	Cation transport ATPase [Inorganic ion transport and metabolism]; Region: MgtA; COG0474
195102006510	Cation transporter/ATPase, N-terminus; Region: Cation_ATPase_N; smart00831
195102006511	E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122
195102006512	Putative hydrolase of sodium-potassium ATPase alpha subunit; Region: Hydrolase_like2; pfam13246
195102006513	Soluble P-type ATPase [General function prediction only]; Region: COG4087
195102006514	Cation transporting ATPase, C-terminus; Region: Cation_ATPase_C; pfam00689
195102006515	putative manganese-dependent inorganic pyrophosphatase; Provisional; Region: PRK14869
195102006516	The CBS domain, named after human CBS, is a small domain originally identified in cystathionine beta-synthase and is subsequently found in a wide range of different proteins. CBS domains usually occur in tandem repeats. They associate to form a so-called...; Region: CBS_pair; cl15354
195102006517	DRTGG domain; Region: DRTGG; pfam07085
195102006518	The CBS domain, named after human CBS, is a small domain originally identified in cystathionine beta-synthase and is subsequently found in a wide range of different proteins. CBS domains usually occur in tandem repeats. They associate to form a so-called...; Region: CBS_pair; cd02205
195102006519	The CBS domain, named after human CBS, is a small domain originally identified in cystathionine beta-synthase and is subsequently found in a wide range of different proteins. CBS domains usually occur in tandem repeats. They associate to form a so-called...; Region: CBS_pair; cl15354
195102006520	DHHA2 domain; Region: DHHA2; pfam02833
195102006521	haloacid dehalogenase-like hydrolase; Region: HAD; cl17202
195102006522	DOPA decarboxylase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to DOPA/tyrosine decarboxylase (DDC), histidine decarboxylase (HDC), and...; Region: DOPA_deC_like; cd06450
195102006523	tyrosine decarboxylase MnfA; Region: tyr_de_CO2_Arch; TIGR03812
195102006524	pyridoxal 5'-phosphate binding site [chemical binding]; other site
195102006525	catalytic residue [active]
195102006526	Protein of unknown function (DUF2776); Region: DUF2776; pfam10951
195102006527	glutamate:gamma-aminobutyrate antiporter; Region: 2A0307_GadC; TIGR00910
195102006528	pyruvate:ferredoxin (flavodoxin) oxidoreductase, homodimeric; Region: pyruv_ox_red; TIGR02176
195102006529	Pyrimidine (PYR) binding domain of pyruvate ferredoxin oxidoreductase (PFOR), indolepyruvate ferredoxin oxidoreductase alpha subunit (IOR-alpha), and related proteins; Region: TPP_PYR_PFOR_IOR-alpha_like; cd07034
195102006530	dimer interface [polypeptide binding]; other site
195102006531	PYR/PP interface [polypeptide binding]; other site
195102006532	TPP binding site [chemical binding]; other site
195102006533	substrate binding site [chemical binding]; other site
195102006534	Transketolase, C-terminal domain; Region: Transketolase_C; pfam02780
195102006535	Pyruvate:ferredoxin oxidoreductase and related 2-oxoacid:ferredoxin oxidoreductases, gamma subunit [Energy production and conversion]; Region: PorG; COG1014
195102006536	Domain of unknown function; Region: EKR; smart00890
195102006537	4Fe-4S binding domain; Region: Fer4_6; pfam12837
195102006538	Thiamine pyrophosphate (TPP family), PFOR_PNO subfamily, TPP-binding module; composed of proteins similar to the single subunit pyruvate ferredoxin oxidoreductase (PFOR) of Desulfovibrio Africanus, present in bacteria and amitochondriate eukaryotes. This...; Region: TPP_PFOR_PNO; cd03377
195102006539	TPP-binding site [chemical binding]; other site
195102006540	dimer interface [polypeptide binding]; other site
195102006541	flavodoxin; Provisional; Region: PRK05569
195102006542	Uncharacterized flavoproteins [Energy production and conversion]; Region: FpaA; COG0426
195102006543	MurG is an N-acetylglucosaminyltransferase, the last enzyme involved in the intracellular phase of peptidoglycan biosynthesis. It transfers N-acetyl-D-glucosamine (GlcNAc) from UDP-GlcNAc to the C4 hydroxyl of a lipid-linked N-acetylmuramoyl pentapeptide...; Region: GT1_MurG; cd03785
195102006544	undecaprenyldiphospho-muramoylpentapeptide beta-N-acetylglucosaminyltransferase; Reviewed; Region: PRK12446
195102006545	active site
195102006546	homodimer interface [polypeptide binding]; other site
195102006547	Small, acid-soluble spore proteins, alpha/beta type; Region: SASP; pfam00269
195102006548	single-stranded-DNA-specific exonuclease RecJ; Region: recJ; TIGR00644
195102006549	DHH family; Region: DHH; pfam01368
195102006550	DHHA1 domain; Region: DHHA1; pfam02272
195102006551	Predicted Zn-dependent peptidases [General function prediction only]; Region: PqqL; COG0612
195102006552	Insulinase (Peptidase family M16); Region: Peptidase_M16; pfam00675
195102006553	Peptidase M16 inactive domain; Region: Peptidase_M16_C; pfam05193
195102006554	DJ-1 family protein; Region: not_thiJ; TIGR01383
195102006555	Type 1 glutamine amidotransferase (GATase1)-like domain found in Human DJ-1; Region: GATase1_DJ-1; cd03135
195102006556	conserved cys residue [active]
195102006557	DNA topoisomerase IV subunit A; Provisional; Region: PRK13979
195102006558	DNA Topoisomerase, subtype IIA; domain A'; bacterial DNA topoisomerase IV (C subunit, ParC), bacterial DNA gyrases (A subunit, GyrA),mammalian DNA toposiomerases II. DNA topoisomerases are essential enzymes that regulate the conformational changes...; Region: TOP4c; cd00187
195102006559	CAP-like domain; other site
195102006560	active site
195102006561	primary dimer interface [polypeptide binding]; other site
195102006562	DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989
195102006563	DNA topoisomerase IV subunit B; Reviewed; Region: PRK05559
195102006564	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
195102006565	ATP binding site [chemical binding]; other site
195102006566	Mg2+ binding site [ion binding]; other site
195102006567	G-X-G motif; other site
195102006568	TopoIIA_Trans_DNA_gyrase: Transducer domain, having a ribosomal S5 domain 2-like fold, of the type found in proteins of the type IIA family of DNA topoisomerases similar to the B subunits of E. coli DNA gyrase and E. coli Topoisomerase IV which are; Region: TopoII_Trans_DNA_gyrase; cd00822
195102006569	anchoring element; other site
195102006570	dimer interface [polypeptide binding]; other site
195102006571	ATP binding site [chemical binding]; other site
195102006572	Topoisomerase-primase domain. This is a nucleotidyl transferase/hydrolase domain found in type IA, type IIA and type IIB topoisomerases, bacterial DnaG-type primases, small primase-like proteins from bacteria and archaea, OLD family nucleases from...; Region: TOPRIM; cl00718
195102006573	active site
195102006574	metal binding site [ion binding]; metal-binding site
195102006575	DNA gyrase B subunit, carboxyl terminus; Region: DNA_gyraseB_C; pfam00986
195102006576	Member of the Rhodanese Homology Domain superfamily. This CD includes several putative ATP /GTP binding proteins including E. coli YbbB; Region: RHOD_YbbB; cd01520
195102006577	tRNA 2-selenouridine synthase; Region: tRNA_sel_U_synt; TIGR03167
195102006578	active site residue [active]
195102006579	Glycosyltransferases, probably involved in cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: COG1215
195102006580	EpsO protein participates in the methanolan synthesis; Region: EpsO_like; cd06438
195102006581	DXD motif; other site
195102006582	putative UV damage endonuclease; Provisional; Region: uvsE; PRK02308
195102006583	putative sporulation protein YtaF; Region: spore_YtaF; TIGR02840
195102006584	trans-2-enoyl-CoA reductase; Provisional; Region: PRK13656
195102006585	NAD(P)H binding domain of trans-2-enoyl-CoA reductase; Region: Eno-Rase_NADH_b; pfam12242
195102006586	Trans-2-enoyl-CoA reductase catalytic region; Region: Enoyl_reductase; pfam12241
195102006587	Enoyl reductase FAD binding domain; Region: Eno-Rase_FAD_bd; pfam07055
195102006588	inner membrane transporter YjeM; Provisional; Region: PRK15238
195102006589	Alpha-glucosidases, family 31 of glycosyl hydrolases [Carbohydrate transport and metabolism]; Region: COG1501
195102006590	Galactose mutarotase-like; Region: Gal_mutarotas_2; pfam13802
195102006591	Alpha-glucosidase II (alpha-D-glucoside glucohydrolase) is a glycosyl hydrolase family 31 (GH31) enzyme, found in bacteria and plants, which has exo-alpha-1,4-glucosidase and oligo-1,6-glucosidase activities. Alpha-glucosidase II has been characterized...; Region: GH31_glucosidase_II_MalA; cd06604
195102006592	trimer interface [polypeptide binding]; other site
195102006593	active site
195102006594	homohexamer (dimer of homotrimer) interface [polypeptide binding]; other site
195102006595	catalytic site [active]
195102006596	Transcriptional regulator/sugar kinase [Transcription / Carbohydrate transport and metabolism]; Region: NagC; COG1940
195102006597	Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cd00012
195102006598	nucleotide binding site [chemical binding]; other site
195102006599	ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653
195102006600	Bacterial extracellular solute-binding protein; Region: SBP_bac_1; pfam01547
195102006601	Domain of unknown function (DUF3502); Region: DUF3502; pfam12010
195102006602	N-terminal catalytic domain of endoplasmic reticulum(ER)/cytosolic class II alpha-mannosidases; glycoside hydrolase family 38 (GH38); Region: GH38N_AMII_ER_cytosolic; cd10789
195102006603	active site
195102006604	catalytic site [active]
195102006605	Alpha mannosidase, middle domain; Region: Alpha-mann_mid; pfam09261
195102006606	Glycosyl hydrolases family 38 C-terminal domain; Region: Glyco_hydro_38C; pfam07748
195102006607	ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395
195102006608	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
195102006609	dimer interface [polypeptide binding]; other site
195102006610	conserved gate region; other site
195102006611	ABC-ATPase subunit interface; other site
195102006612	ABC-type polysaccharide transport system, permease component [Carbohydrate transport and metabolism]; Region: LplB; COG4209
195102006613	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
195102006614	ABC-ATPase subunit interface; other site
195102006615	MoaC family, prokaryotic and eukaryotic. Members of this family are involved in molybdenum cofactor (Moco) biosynthesis, an essential cofactor of a diverse group of redox enzymes. MoaC, a small hexameric protein, converts, together with MoaA, a guanosine...; Region: MoaC_PE; cd01420
195102006616	trimer interface [polypeptide binding]; other site
195102006617	dimer interface [polypeptide binding]; other site
195102006618	putative active site [active]
195102006619	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
195102006620	dimer interface [polypeptide binding]; other site
195102006621	conserved gate region; other site
195102006622	putative PBP binding loops; other site
195102006623	ABC-ATPase subunit interface; other site
195102006624	ABC-type molybdate transport system, periplasmic component [Inorganic ion transport and metabolism]; Region: ModA; COG0725
195102006625	Bacterial extracellular solute-binding protein; Region: SBP_bac_1; cl17199
195102006626	MogA_MoaB family. Members of this family are involved in biosynthesis of the molybdenum cofactor (MoCF) an essential cofactor of a diverse group of redox enzymes. MoCF biosynthesis is an evolutionarily conserved pathway present in eubacteria, archaea; Region: MogA_MoaB; cd00886
195102006627	MPT binding site; other site
195102006628	trimer interface [polypeptide binding]; other site
195102006629	Response regulator receiver domain; Region: Response_reg; pfam00072
195102006630	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
195102006631	active site
195102006632	phosphorylation site [posttranslational modification]
195102006633	intermolecular recognition site; other site
195102006634	dimerization interface [polypeptide binding]; other site
195102006635	helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342
195102006636	Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165
195102006637	Predicted signal transduction protein with a C-terminal ATPase domain [Signal transduction mechanisms]; Region: COG2972
195102006638	Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225
195102006639	dimerization interface [polypeptide binding]; other site
195102006640	Histidine kinase; Region: His_kinase; pfam06580
195102006641	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
195102006642	ATP binding site [chemical binding]; other site
195102006643	Mg2+ binding site [ion binding]; other site
195102006644	G-X-G motif; other site
195102006645	Protein of unknown function, DUF624; Region: DUF624; pfam04854
195102006646	FemAB family; Region: FemAB; pfam02388
195102006647	Acetyltransferase (GNAT) domain; Region: Acetyltransf_6; pfam13480
195102006648	Transcriptional regulator PadR-like family; Region: PadR; cl17335
195102006649	Predicted transcriptional regulators [Transcription]; Region: COG1695
195102006650	ABC-type polar amino acid transport system, ATPase component [Amino acid transport and metabolism]; Region: GlnQ; COG1126
195102006651	ATP-binding cassette domain of the histidine and glutamine transporters; Region: ABC_HisP_GlnQ; cd03262
195102006652	Walker A/P-loop; other site
195102006653	ATP binding site [chemical binding]; other site
195102006654	Q-loop/lid; other site
195102006655	ABC transporter signature motif; other site
195102006656	Walker B; other site
195102006657	D-loop; other site
195102006658	H-loop/switch region; other site
195102006659	Bacterial extracellular solute-binding proteins, family 3; Region: SBP_bac_3; pfam00497
195102006660	Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of  substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134
195102006661	substrate binding pocket [chemical binding]; other site
195102006662	membrane-bound complex binding site; other site
195102006663	hinge residues; other site
195102006664	ABC-type arginine transport system, permease component [Amino acid transport and metabolism]; Region: ArtQ; COG4215
195102006665	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
195102006666	dimer interface [polypeptide binding]; other site
195102006667	conserved gate region; other site
195102006668	putative PBP binding loops; other site
195102006669	ABC-ATPase subunit interface; other site
195102006670	Flavodoxin-like fold; Region: Flavodoxin_2; cl00438
195102006671	4Fe-4S dicluster domain; Region: Fer4_9; pfam13187
195102006672	Protein of unknown function DUF86; Region: DUF86; pfam01934
195102006673	Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225
195102006674	dimerization interface [polypeptide binding]; other site
195102006675	Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642
195102006676	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
195102006677	dimer interface [polypeptide binding]; other site
195102006678	phosphorylation site [posttranslational modification]
195102006679	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
195102006680	ATP binding site [chemical binding]; other site
195102006681	Mg2+ binding site [ion binding]; other site
195102006682	G-X-G motif; other site
195102006683	Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745
195102006684	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
195102006685	active site
195102006686	phosphorylation site [posttranslational modification]
195102006687	intermolecular recognition site; other site
195102006688	dimerization interface [polypeptide binding]; other site
195102006689	Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383
195102006690	DNA binding site [nucleotide binding]
195102006691	Protein of unknown function (DUF503); Region: DUF503; pfam04456
195102006692	DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046
195102006693	ATP binding site [chemical binding]; other site
195102006694	Superfamily II DNA and RNA helicases [DNA replication, recombination, and repair / Transcription / Translation, ribosomal structure and biogenesis]; Region: SrmB; COG0513
195102006695	putative Mg++ binding site [ion binding]; other site
195102006696	Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079
195102006697	nucleotide binding region [chemical binding]; other site
195102006698	ATP-binding site [chemical binding]; other site
195102006699	Mitochondrial degradasome RNA helicase subunit C terminal; Region: SUV3_C; pfam12513
195102006700	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
195102006701	S-adenosylmethionine binding site [chemical binding]; other site
195102006702	Heptaprenyl diphosphate synthase component I; Region: Hpre_diP_synt_I; pfam07456
195102006703	Listerrria innocua Lin0431  is similar to the N-Utilization Substance G (NusG) N terminal (NGN) insert (DII); Region: Lin0431_like; cd09911
195102006704	trimer interface [polypeptide binding]; other site
195102006705	Membrane-associated lipoprotein involved in thiamine biosynthesis [Coenzyme metabolism]; Region: ApbE; COG1477
195102006706	ApbE family; Region: ApbE; pfam02424
195102006707	Protein of unknown function (DUF1533); Region: DUF1533; pfam07550
195102006708	Protein of unknown function (DUF1533); Region: DUF1533; pfam07550
195102006709	Protein of unknown function (DUF1533); Region: DUF1533; pfam07550
195102006710	Protein of unknown function (DUF1533); Region: DUF1533; pfam07550
195102006711	Protein of unknown function (DUF1533); Region: DUF1533; pfam07550
195102006712	Protein of unknown function (DUF1533); Region: DUF1533; pfam07550
195102006713	Protein of unknown function (DUF1533); Region: DUF1533; pfam07550
195102006714	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cl17904
195102006715	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
195102006716	Peptidase S8 family domain in CspA-like proteins; Region: Peptidases_S8_CspA-like; cd07478
195102006717	active site
195102006718	catalytic triad [active]
195102006719	Subtilisin-like serine proteases [Posttranslational modification, protein turnover, chaperones]; Region: AprE; COG1404
195102006720	Peptidase S8 family domain in CspA-like proteins; Region: Peptidases_S8_CspA-like; cd07478
195102006721	active site
195102006722	catalytic triad [active]
195102006723	SAM-dependent methyltransferases related to tRNA (uracil-5-)-methyltransferase [Translation, ribosomal structure and biogenesis]; Region: TrmA; COG2265
195102006724	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
195102006725	S-adenosylmethionine binding site [chemical binding]; other site
195102006726	RDD family; Region: RDD; cl00746
195102006727	Selenocysteine-specific translation elongation factor [Translation, ribosomal structure and biogenesis]; Region: SelB; COG3276
195102006728	SelB, the dedicated elongation factor for delivery of selenocysteinyl-tRNA to the ribosome; Region: SelB; cd04171
195102006729	G1 box; other site
195102006730	putative GEF interaction site [polypeptide binding]; other site
195102006731	GTP/Mg2+ binding site [chemical binding]; other site
195102006732	Switch I region; other site
195102006733	G2 box; other site
195102006734	G3 box; other site
195102006735	Switch II region; other site
195102006736	G4 box; other site
195102006737	G5 box; other site
195102006738	selB_II: this subfamily represents the domain of elongation factor SelB, homologous to domain II of EF-Tu. SelB may function by replacing EF-Tu. In prokaryotes, the incorporation of selenocysteine as the 21st amino acid, encoded by TGA, requires several...; Region: selB_II; cd03696
195102006739	This family represents the domain of elongation factor SelB, homologous to domain III of EF-Tu. SelB may function by replacing EF-Tu. In prokaryotes, the incorporation of selenocysteine as the 21st amino acid, encoded by TGA, requires several elements:...; Region: selB_III; cd04094
195102006740	Elongation factor SelB, winged helix; Region: SelB-wing_2; pfam09106
195102006741	Elongation factor SelB, winged helix; Region: SelB-wing_3; pfam09107
195102006742	seryl-tRNA(sec) selenium transferase; Region: selA; TIGR00474
195102006743	Selenocysteine synthase N terminal; Region: Se-cys_synth_N; pfam12390
195102006744	Selenocysteine synthase [seryl-tRNASer selenium transferase] [Amino acid transport and metabolism]; Region: SelA; COG1921
195102006745	pyridoxal 5'-phosphate binding pocket [chemical binding]; other site
195102006746	catalytic residue [active]
195102006747	Selenophosphate synthetase  (SelD) catalyzes the conversion of selenium to selenophosphate which is required by a number of bacterial, archaeal and eukaryotic organisms for synthesis of Secys-tRNA, the precursor of selenocysteine in selenoenzymes. The...; Region: SelD; cd02195
195102006748	dimerization interface [polypeptide binding]; other site
195102006749	putative ATP binding site [chemical binding]; other site
195102006750	SLBB domain; Region: SLBB; pfam10531
195102006751	comEA protein; Region: comE; TIGR01259
195102006752	Helix-hairpin-helix motif; Region: HHH; pfam00633
195102006753	Beta-lactamase enzyme family; Region: Beta-lactamase2; cl17872
195102006754	D-alanyl-D-alanine carboxypeptidase; Region: Peptidase_S11; pfam00768
195102006755	Penicillin-binding protein 5, C-terminal domain; Region: PBP5_C; pfam07943
195102006756	Pseudouridylate synthases, 23S RNA-specific [Translation, ribosomal structure and biogenesis]; Region: RluA; COG0564
195102006757	Pseudouridine synthase, RsuA/RluD family; Region: PseudoU_synth_RluCD_like; cd02869
195102006758	active site
195102006759	Transcriptional regulator [Transcription]; Region: LytR; COG1316
195102006760	LytR cell envelope-related transcriptional attenuator; Region: LytR_C; pfam13399
195102006761	Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077
195102006762	Zn2+ binding site [ion binding]; other site
195102006763	Mg2+ binding site [ion binding]; other site
195102006764	nicotinic acid mononucleotide adenylyltransferase; Provisional; Region: nadD; PRK00071
195102006765	Nicotinamide/nicotinate mononucleotide adenylyltransferase; Region: NMNAT; cd02165
195102006766	active site
195102006767	(T/H)XGH motif; other site
195102006768	Predicted RNA-binding protein containing KH domain, possibly ribosomal protein [Translation, ribosomal structure and biogenesis]; Region: COG1534
195102006769	GTPase CgtA; Reviewed; Region: obgE; PRK12297
195102006770	GTP1/OBG; Region: GTP1_OBG; pfam01018
195102006771	Obg GTPase; Region: Obg; cd01898
195102006772	G1 box; other site
195102006773	GTP/Mg2+ binding site [chemical binding]; other site
195102006774	Switch I region; other site
195102006775	G2 box; other site
195102006776	G3 box; other site
195102006777	Switch II region; other site
195102006778	G4 box; other site
195102006779	G5 box; other site
195102006780	Domain of unknown function (DUF1967); Region: DUF1967; pfam09269
195102006781	50S ribosomal protein L27; Validated; Region: rpmA; PRK05435
195102006782	hypothetical protein; Provisional; Region: PRK14553
195102006783	50S ribosomal protein L21; Validated; Region: rplU; PRK05573
195102006784	ribonuclease, Rne/Rng family; Region: RNaseEG; TIGR00757
195102006785	S1_RNase_E: RNase E and RNase G, S1-like RNA-binding domain. RNase E is an essential endoribonuclease in the processing and degradation of RNA. In addition to its role in mRNA degradation, RNase E has also been implicated in the processing of rRNA, and...; Region: S1_RNase_E; cd04453
195102006786	homodimer interface [polypeptide binding]; other site
195102006787	oligonucleotide binding site [chemical binding]; other site
195102006788	radical SAM-linked protein; Region: sam_1_link_chp; TIGR03936
195102006789	Uncharacterized protein conserved in bacteria (DUF2344); Region: DUF2344; pfam10105
195102006790	radical SAM family uncharacterized protein; Region: rSAM_fuse_unch; TIGR03960
195102006791	Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335
195102006792	FeS/SAM binding site; other site
195102006793	SpoIVFB Site-2 protease (S2P), a zinc metalloprotease (MEROPS family M50B), regulates intramembrane proteolysis (RIP), and is involved in the pro-sigmaK pathway of bacterial spore formation. SpoIVFB (sporulation protein, stage IV cell wall formation, F...; Region: S2P-M50_SpoIVFB; cd06161
195102006794	Peptidase family M50; Region: Peptidase_M50; pfam02163
195102006795	active site
195102006796	putative substrate binding region [chemical binding]; other site
195102006797	rod shape-determining protein RodA; Region: rodA_shape; TIGR02210
195102006798	cell division topological specificity factor MinE; Provisional; Region: PRK13987
195102006799	septum site-determining protein MinD; Region: minD_bact; TIGR01968
195102006800	Bacterial cell division requires the formation of a septum at mid-cell. The site is determined by the min operon products MinC, MinD and MinE. MinC is a nonspecific inhibitor of the septum protein FtsZ. MinE is the supressor of MinC. MinD plays a pivotal...; Region: MinD; cd02036
195102006801	Switch I; other site
195102006802	Switch II; other site
195102006803	septum formation inhibitor; Reviewed; Region: minC; PRK00513
195102006804	Septum formation inhibitor MinC, C-terminal domain; Region: MinC_C; pfam03775
195102006805	Penicillin-binding Protein dimerisation domain; Region: PBP_dimer; pfam03717
195102006806	Penicillin-binding Protein dimerisation domain; Region: PBP_dimer; pfam03717
195102006807	Penicillin binding protein transpeptidase domain; Region: Transpeptidase; cl17760
195102006808	Penicillin binding protein transpeptidase domain; Region: Transpeptidase; cl17760
195102006809	rod shape-determining protein MreD; Region: shape_MreD; TIGR03426
195102006810	rod shape-determining protein MreC; Provisional; Region: PRK13922
195102006811	rod shape-determining protein MreC; Region: MreC; pfam04085
195102006812	rod shape-determining protein MreB; Provisional; Region: PRK13927
195102006813	MreB and similar proteins; Region: MreB_like; cd10225
195102006814	nucleotide binding site [chemical binding]; other site
195102006815	Mg binding site [ion binding]; other site
195102006816	putative protofilament interaction site [polypeptide binding]; other site
195102006817	RodZ interaction site [polypeptide binding]; other site
195102006818	hypothetical protein; Reviewed; Region: PRK00024
195102006819	Mov34/MPN/PAD-1 family; Region: MPN_DUF2466; cd08071
195102006820	MPN+ (JAMM) motif; other site
195102006821	Zinc-binding site [ion binding]; other site
195102006822	Maf-like protein; Reviewed; Region: PRK00078
195102006823	Nucleotide binding protein Maf. Maf has been implicated in inhibition of septum formation in eukaryotes, bacteria and archaea, but homologs in B.subtilis and S.cerevisiae are nonessential for cell division. Maf has been predicted to be a nucleotide- or...; Region: Maf; cd00555
195102006824	active site
195102006825	dimer interface [polypeptide binding]; other site
195102006826	Sporulation related domain; Region: SPOR; pfam05036
195102006827	Predicted metal-dependent phosphoesterases (PHP family) [General function prediction only]; Region: COG0613
195102006828	Polymerase and Histidinol Phosphatase domain of Histidinol phosphate phosphatase (HisPPase) AMP bound; Region: PHP_HisPPase_AMP; cd07438
195102006829	active site
195102006830	Polymerase and Histidinol Phosphatase domain of Histidinol phosphate phosphatase (HisPPase) AMP bound; Region: PHP_HisPPase_AMP; cd07438
195102006831	Xaa-His dipeptidase; Region: aa-his-dipept; TIGR01893
195102006832	M20 Peptidase D has specificity for beta-alanyl-L-histidine dipeptide; Region: M20_pepD; cd03890
195102006833	metal binding site [ion binding]; metal-binding site
195102006834	dimer interface [polypeptide binding]; other site
195102006835	Pyruvate kinase [Carbohydrate transport and metabolism]; Region: PykF; COG0469
195102006836	Pyruvate kinase (PK):  Large allosteric enzyme that regulates glycolysis through binding of the substrate, phosphoenolpyruvate, and one or more allosteric effectors. Like other allosteric enzymes, PK has a high substrate affinity R state and a low...; Region: Pyruvate_Kinase; cl17342
195102006837	domain interfaces; other site
195102006838	active site
195102006839	30S ribosomal protein S1; Reviewed; Region: rpsA; PRK06676
195102006840	S1_RPS1_repeat_ec1_hs1: Ribosomal protein S1 (RPS1) domain. RPS1 is a component of the small ribosomal subunit thought to be involved in the recognition and binding of mRNA's during translation initiation. The bacterial RPS1 domain architecture...; Region: S1_RPS1_repeat_ec1_hs1; cd05687
195102006841	RNA binding site [nucleotide binding]; other site
195102006842	S1_RPS1_repeat_ec2_hs2: Ribosomal protein S1 (RPS1) domain. RPS1 is a component of the small ribosomal subunit thought to be involved in the recognition and binding of mRNA's during translation initiation. The bacterial RPS1 domain architecture...; Region: S1_RPS1_repeat_ec2_hs2; cd04465
195102006843	RNA binding site [nucleotide binding]; other site
195102006844	S1_like: Ribosomal protein S1-like RNA-binding domain. Found in a wide variety of RNA-associated proteins. Originally identified in S1 ribosomal protein. This superfamily also contains the Cold Shock Domain (CSD), which is a homolog of the S1 domain; Region: S1_like; cl09927
195102006845	RNA binding site [nucleotide binding]; other site
195102006846	S1_PNPase: Polynucleotide phosphorylase (PNPase), ), S1-like RNA-binding domain. PNPase  is a polyribonucleotide nucleotidyl transferase that degrades mRNA. It is a trimeric multidomain protein. The C-terminus contains the S1 domain which binds ssRNA; Region: S1_PNPase; cd04472
195102006847	RNA binding site [nucleotide binding]; other site
195102006848	domain interface; other site
195102006849	Heavy-metal-associated domain (HMA) is a conserved domain of approximately 30 amino acid residues found in a number of proteins that transport or detoxify heavy metals, for example, the CPx-type heavy metal ATPases and copper chaperones. HMA domain...; Region: HMA; cl00207
195102006850	metal-binding site [ion binding]
195102006851	hypothetical protein; Validated; Region: PRK02101
195102006852	FOG: CBS domain [General function prediction only]; Region: COG0517
195102006853	The CBS domain, named after human CBS, is a small domain originally identified in cystathionine beta-synthase and is subsequently found in a wide range of different proteins. CBS domains usually occur in tandem repeats. They associate to form a so-called...; Region: CBS_pair_30; cd04643
195102006854	DEDDh 3'-5' exonuclease domain of Caenorhabditis elegans ERI-1, human 3' exonuclease, and similar proteins; Region: ERI-1_3'hExo_like; cd06133
195102006855	DNA polymerase III, epsilon subunit and related 3'-5' exonucleases [DNA replication, recombination, and repair]; Region: DnaQ; COG0847
195102006856	active site
195102006857	catalytic site [active]
195102006858	substrate binding site [chemical binding]; other site
195102006859	Protein of unknown function DUF262; Region: DUF262; pfam03235
195102006860	Uncharacterized conserved protein [Function unknown]; Region: COG1479
195102006861	Protein of unknown function DUF262; Region: DUF262; pfam03235
195102006862	Protein of unknown function (DUF1524); Region: DUF1524; pfam07510
195102006863	ATP-binding cassette domain of MutS-like homolog; Region: ABC_MutS-like; cd03283
195102006864	Walker A/P-loop; other site
195102006865	ATP binding site [chemical binding]; other site
195102006866	Q-loop/lid; other site
195102006867	ABC transporter signature motif; other site
195102006868	Walker B; other site
195102006869	D-loop; other site
195102006870	H-loop/switch region; other site
195102006871	PTS system, glucose-specific IIBC component; Region: PTS-II-BC-glcB; TIGR02002
195102006872	Phosphotransferase system IIC components, glucose/maltose/N-acetylglucosamine-specific [Carbohydrate transport and metabolism]; Region: PtsG; COG1263
195102006873	PTS_IIB, PTS system, glucose/sucrose specific IIB subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIB_glc; cd00212
195102006874	active site turn [active]
195102006875	phosphorylation site [posttranslational modification]
195102006876	ABC-type metal ion transport system, periplasmic component/surface adhesin [Inorganic ion transport and metabolism]; Region: LraI; COG0803
195102006877	Metal binding protein AcdA.  These proteins have been shown to function in the ABC uptake of Zn2+ and Mn2+ and in competence for genetic transformation and adhesion. The AcdA proteins belong to the TroA superfamily of helical backbone metal receptor...; Region: AdcA; cd01017
195102006878	metal binding site [ion binding]; metal-binding site
195102006879	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
195102006880	Walker A/P-loop; other site
195102006881	ATP binding site [chemical binding]; other site
195102006882	DNA repair exonuclease [DNA replication, recombination, and repair]; Region: SbcD; COG0420
195102006883	Mre11 nuclease, N-terminal metallophosphatase domain; Region: MPP_Mre11_N; cd00840
195102006884	active site
195102006885	metal binding site [ion binding]; metal-binding site
195102006886	DNA binding site [nucleotide binding]
195102006887	Small, acid-soluble spore proteins, alpha/beta type; Region: SASP; pfam00269
195102006888	5'-nucleotidase/2',3'-cyclic phosphodiesterase and related esterases [Nucleotide transport and metabolism]; Region: UshA; COG0737
195102006889	Escherichia coli CpdB and related proteins, N-terminal metallophosphatase domain; Region: MPP_CpdB_N; cd07410
195102006890	active site
195102006891	metal binding site [ion binding]; metal-binding site
195102006892	5'-nucleotidase, C-terminal domain; Region: 5_nucleotid_C; pfam02872
195102006893	FOG: CBS domain [General function prediction only]; Region: COG0517
195102006894	The CBS domain, named after human CBS, is a small domain originally identified in cystathionine beta-synthase and is subsequently found in a wide range of different proteins. CBS domains usually occur in tandem repeats. They associate to form a so-called...; Region: CBS_pair; cd02205
195102006895	ACT domains are commonly involved in specifically binding an amino acid or other small ligand leading to regulation of the enzyme; Region: ACT; cl09141
195102006896	Predicted ATPase or kinase [General function prediction only]; Region: COG0802
195102006897	tRNA threonylcarbamoyl adenosine modification protein YeaZ; Region: T6A_YeaZ; TIGR03725
195102006898	Glycoprotease family; Region: Peptidase_M22; pfam00814
195102006899	ribosomal-protein-alanine acetyltransferase; Region: rimI; TIGR01575
195102006900	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301
195102006901	Coenzyme A binding pocket [chemical binding]; other site
195102006902	Predicted membrane protein [Function unknown]; Region: COG3601
195102006903	Protein of unknown function (DUF3816); Region: DUF3816; pfam12822
195102006904	Transcriptional accessory protein [Transcription]; Region: Tex; COG2183
195102006905	Tex-like protein N-terminal domain; Region: Tex_N; pfam09371
195102006906	Likely ribonuclease with RNase H fold; Region: YqgFc; smart00732
195102006907	S1_Tex: The C-terminal S1 domain of a transcription accessory factor called Tex, which has been characterized in Bordetella pertussis and Pseudomonas aeruginosa. The tex gene is essential in Bortella pertusis and is named for its role in toxin expression; Region: S1_Tex; cd05685
195102006908	RNA binding site [nucleotide binding]; other site
195102006909	Zinc peptidases M18, M20, M28, and M42; Region: Zinc_peptidase_like; cl14876
195102006910	M28 Zn-Peptidases containing a PA domain insert; Region: M28_like_PA; cd03877
195102006911	Peptidase family M28; Region: Peptidase_M28; pfam04389
195102006912	metal binding site [ion binding]; metal-binding site
195102006913	peptide chain release factor 2; Provisional; Region: PRK05589
195102006914	PCRF domain; Region: PCRF; pfam03462
195102006915	RF-1 domain; Region: RF-1; pfam00472
195102006916	preprotein translocase subunit SecA; Reviewed; Region: PRK12904
195102006917	DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cl17251
195102006918	ATP binding site [chemical binding]; other site
195102006919	putative Mg++ binding site [ion binding]; other site
195102006920	SecA preprotein cross-linking domain; Region: SecA_PP_bind; smart00958
195102006921	SEC-C motif; Region: SEC-C; pfam02810
195102006922	RaiA ("ribosome-associated inhibitor A", also known as Protein Y (PY), YfiA, and SpotY,  is a stress-response protein that binds the ribosomal subunit interface and arrests translation by interfering with aminoacyl-tRNA binding to the ribosomal...; Region: RaiA; cd00552
195102006923	30S subunit binding site; other site
195102006924	comF family protein; Region: comF; TIGR00201
195102006925	Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223
195102006926	active site
195102006927	helicase, putative, RecD/TraA family; Region: recD_rel; TIGR01448
195102006928	AAA domain; Region: AAA_30; pfam13604
195102006929	Family description; Region: UvrD_C_2; pfam13538
195102006930	N-acetylglucosamine-6-phosphate deacetylase [Carbohydrate transport and metabolism]; Region: NagA; COG1820
195102006931	N-acetylglucosamine-6-phosphate deacetylase, NagA, catalyzes the hydrolysis of the N-acetyl group of N-acetyl-glucosamine-6-phosphate (GlcNAc-6-P) to glucosamine 6-phosphate and acetate. This is the first committed step in the biosynthetic pathway to...; Region: NagA; cd00854
195102006932	active site
195102006933	dimer interface [polypeptide binding]; other site
195102006934	S-adenosylmethionine synthetase; Validated; Region: PRK05250
195102006935	S-adenosylmethionine synthetase, N-terminal domain; Region: S-AdoMet_synt_N; pfam00438
195102006936	S-adenosylmethionine synthetase, central domain; Region: S-AdoMet_synt_M; pfam02772
195102006937	S-adenosylmethionine synthetase, C-terminal domain; Region: S-AdoMet_synt_C; pfam02773
195102006938	Protein of unknown function (DUF1256); Region: DUF1256; pfam06866
195102006939	rod shape-determining protein Mbl; Provisional; Region: PRK13928
195102006940	MreB and similar proteins; Region: MreB_like; cd10225
195102006941	nucleotide binding site [chemical binding]; other site
195102006942	Mg binding site [ion binding]; other site
195102006943	putative protofilament interaction site [polypeptide binding]; other site
195102006944	RodZ interaction site [polypeptide binding]; other site
195102006945	sporulation transcriptional regulator SpoIIID; Region: spore_III_D; TIGR02844
195102006946	Membrane proteins related to metalloendopeptidases [Cell envelope biogenesis, outer membrane]; Region: NlpD; COG0739
195102006947	Peptidase family M23; Region: Peptidase_M23; pfam01551
195102006948	Stage II sporulation protein; Region: SpoIID; pfam08486
195102006949	SpoIID/LytB domain; Region: SpoIID_LytB; TIGR02669
195102006950	UDP-N-acetylglucosamine 1-carboxyvinyltransferase; Region: murA; TIGR01072
195102006951	UDP-N-acetylglucosamine enolpyruvyl transferase catalyzes enolpyruvyl transfer as part of the first step in the biosynthesis of peptidoglycan, a component of the bacterial cell wall. The reaction is phosphoenolpyruvate + UDP-N-acetyl-D-glucosamine =...; Region: UdpNAET; cd01555
195102006952	hinge; other site
195102006953	active site
195102006954	F0F1 ATP synthase subunit epsilon; Provisional; Region: atpC; PRK13450
195102006955	mitochondrial ATP synthase delta subunit; Region: F1-ATPase_delta; cd12152
195102006956	gamma subunit interface [polypeptide binding]; other site
195102006957	epsilon subunit interface [polypeptide binding]; other site
195102006958	LBP interface [polypeptide binding]; other site
195102006959	F0F1 ATP synthase subunit beta; Validated; Region: PRK09280
195102006960	ATP synthase alpha/beta family, beta-barrel domain; Region: ATP-synt_ab_N; pfam02874
195102006961	F1 ATP synthase beta subunit, nucleotide-binding domain. The F-ATPase is found in bacterial plasma membranes, mitochondrial inner membranes and in chloroplast thylakoid membranes. It has also been found in the archaea Methanosarcina barkeri. It uses a...; Region: F1-ATPase_beta; cd01133
195102006962	alpha subunit interaction interface [polypeptide binding]; other site
195102006963	Walker A motif; other site
195102006964	ATP binding site [chemical binding]; other site
195102006965	Walker B motif; other site
195102006966	inhibitor binding site; inhibition site
195102006967	ATP synthase alpha/beta chain, C terminal domain; Region: ATP-synt_ab_C; pfam00306
195102006968	mitochondrial ATP synthase gamma subunit; Region: F1-ATPase_gamma; cd12151
195102006969	core domain interface [polypeptide binding]; other site
195102006970	delta subunit interface [polypeptide binding]; other site
195102006971	epsilon subunit interface [polypeptide binding]; other site
195102006972	F0F1 ATP synthase subunit alpha; Validated; Region: PRK09281
195102006973	ATP synthase alpha/beta family, beta-barrel domain; Region: ATP-synt_ab_N; pfam02874
195102006974	F1 ATP synthase alpha, central domain. The F-ATPase is found in bacterial plasma membranes, mitochondrial inner membranes and in chloroplast thylakoid membranes. It has also been found in the archaea Methanosarcina barkeri. It uses a proton gradient to...; Region: F1_ATPase_alpha; cd01132
195102006975	beta subunit interaction interface [polypeptide binding]; other site
195102006976	Walker A motif; other site
195102006977	ATP binding site [chemical binding]; other site
195102006978	Walker B motif; other site
195102006979	ATP synthase alpha/beta chain, C terminal domain; Region: ATP-synt_ab_C; pfam00306
195102006980	F0F1 ATP synthase subunit delta; Validated; Region: PRK05758
195102006981	ATP synthase delta (OSCP) subunit; Region: OSCP; pfam00213
195102006982	F0F1 ATP synthase subunit B; Provisional; Region: PRK13461
195102006983	F0F1 ATP synthase subunit B; Validated; Region: PRK05759
195102006984	F0F1 ATP synthase subunit C; Provisional; Region: PRK13469
195102006985	F0F1 ATP synthase subunit A; Validated; Region: PRK05815
195102006986	F0F1-type ATP synthase, subunit a [Energy production and conversion]; Region: AtpB; COG0356
195102006987	putative acyltransferase; Provisional; Region: PRK05790
195102006988	Thiolase are ubiquitous enzymes that catalyze the reversible thiolytic cleavage of 3-ketoacyl-CoA into acyl-CoA and acetyl-CoA, a 2-step reaction involving a covalent intermediate formed with a catalytic cysteine. They are found in prokaryotes and...; Region: thiolase; cd00751
195102006989	dimer interface [polypeptide binding]; other site
195102006990	active site
195102006991	UDP-N-acetylglucosamine 2-epimerase [Cell envelope biogenesis, outer membrane]; Region: WecB; COG0381
195102006992	Bacterial members of the UDP-N-Acetylglucosamine (GlcNAc) 2-Epimerase  family are known to catalyze the reversible interconversion of UDP-GlcNAc and UDP-N-acetylmannosamine (UDP-ManNAc). The enzyme serves to produce an activated form of ManNAc residues; Region: GT1_UDP-GlcNAc_2-Epimerase; cd03786
195102006993	active site
195102006994	homodimer interface [polypeptide binding]; other site
195102006995	Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223
195102006996	active site
195102006997	ribose-5-phosphate isomerase B; Provisional; Region: PRK05571
195102006998	Putative translation factor (SUA5) [Translation, ribosomal structure and biogenesis]; Region: SUA5; COG0009
195102006999	Putative GTP-binding controlling metal-binding; Region: SUA5; pfam03481
195102007000	peptide chain release factor 1; Validated; Region: prfA; PRK00591
195102007001	This domain is found in peptide chain release factors; Region: PCRF; smart00937
195102007002	RF-1 domain; Region: RF-1; pfam00472
195102007003	Protein of unknown function (DUF1385); Region: DUF1385; pfam07136
195102007004	N5-glutamine S-adenosyl-L-methionine-dependent methyltransferase; Provisional; Region: PRK09328
195102007005	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
195102007006	S-adenosylmethionine binding site [chemical binding]; other site
195102007007	thymidine kinase; Provisional; Region: PRK04296
195102007008	50S ribosomal protein L31; Reviewed; Region: rpmE; PRK00019
195102007009	diacylglycerol glucosyltransferase; Provisional; Region: PRK13609
195102007010	Monogalactosyldiacylglycerol (MGDG) synthase; Region: MGDG_synth; pfam06925
195102007011	Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013
195102007012	transcription termination factor Rho; Provisional; Region: PRK12608
195102007013	Rho_CSD: Rho protein cold-shock domain (CSD). Rho protein is a transcription termination factor in most bacteria. In bacteria, there are two distinct mechanisms for mRNA transcription termination. In intrinsic termination, RNA polymerase and nascent mRNA...; Region: Rho_CSD; cd04459
195102007014	RNA binding site [nucleotide binding]; other site
195102007015	Transcription termination factor rho is a bacterial ATP-dependent RNA/DNA helicase. It is a homohexamer. Each monomer consists of an N-terminal domain of the OB fold, which is responsible for binding to cysteine rich nucleotides. This alignment is of the...; Region: rho_factor; cd01128
195102007016	multimer interface [polypeptide binding]; other site
195102007017	Walker A motif; other site
195102007018	ATP binding site [chemical binding]; other site
195102007019	Walker B motif; other site
195102007020	CTP synthetase; Validated; Region: pyrG; PRK05380
195102007021	CTP synthetase (CTPs) is a two-domain protein, which consists of an N-terminal synthetase domain and C-terminal glutaminase domain. The enzymes hydrolyze the amide bond of glutamine to ammonia and glutamate at the glutaminase domains and transfer nascent...; Region: CTGs; cd03113
195102007022	Catalytic site [active]
195102007023	active site
195102007024	UTP binding site [chemical binding]; other site
195102007025	Type 1 glutamine amidotransferase (GATase1) domain found in Cytidine Triphosphate Synthetase; Region: GATase1_CTP_Synthase; cd01746
195102007026	active site
195102007027	putative oxyanion hole; other site
195102007028	catalytic triad [active]
195102007029	Domain of unknown function (DUF1934); Region: DUF1934; pfam09148
195102007030	Predicted tRNA(5-methylaminomethyl-2-thiouridylate) methyltransferase, contains the PP-loop ATPase domain [Translation, ribosomal structure and biogenesis]; Region: TrmU; COG0482
195102007031	ThiI is required for thiazole synthesis in the thiamine biosynthesis pathway. It belongs to the Adenosine Nucleotide Hydrolysis suoerfamily and predicted to bind to Adenosine nucleotide; Region: ThiI; cd01712
195102007032	Ligand Binding Site [chemical binding]; other site
195102007033	stage II sporulation protein R; Region: spore_II_R; TIGR02837
195102007034	4-diphosphocytidyl-2-C-methyl-D-erythritol kinase; Provisional; Region: ipk; PRK00128
195102007035	GHMP kinases N terminal domain; Region: GHMP_kinases_N; pfam00288
195102007036	cyanophycin synthetase; Provisional; Region: PRK14016
195102007037	ATP-grasp domain; Region: ATP-grasp_4; cl17255
195102007038	Mur ligase middle domain; Region: Mur_ligase_M; pfam08245
195102007039	Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875
195102007040	Type 1 glutamine amidotransferase (GATase1)-like domain found in cyanophycinase; Region: GAT1_cyanophycinase; cd03145
195102007041	proposed catalytic triad [active]
195102007042	active site nucleophile [active]
195102007043	Domain of unknown function (DUF3794); Region: DUF3794; pfam12673
195102007044	Domain of unknown function (DUF3794); Region: DUF3794; pfam12673
195102007045	Domain of unknown function (DUF3794); Region: DUF3794; pfam12673
195102007046	Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118
195102007047	Protein of unknown function (DUF1021); Region: DUF1021; pfam06257
195102007048	YabG peptidase U57; Region: Peptidase_U57; pfam05582
195102007049	Aminoglycoside 3'-phosphotransferase (APH) and Choline Kinase (ChoK) family. The APH/ChoK family is part of a larger superfamily that includes the catalytic domains of other kinases, such as the typical serine/threonine/tyrosine protein kinases (PKs)...; Region: APH_ChoK_like; cl17270
195102007050	spore coat protein, CotS family; Region: spore_CotS; TIGR02906
195102007051	active site
195102007052	ATP binding site [chemical binding]; other site
195102007053	Aminoglycoside 3'-phosphotransferase (APH) and Choline Kinase (ChoK) family. The APH/ChoK family is part of a larger superfamily that includes the catalytic domains of other kinases, such as the typical serine/threonine/tyrosine protein kinases (PKs)...; Region: APH_ChoK_like; cd05120
195102007054	substrate binding site [chemical binding]; other site
195102007055	Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438
195102007056	This family is most closely related to the GT1 family of glycosyltransferases. mtfB (mannosyltransferase B) in E. coli has been shown to direct the growth of the O9-specific polysaccharide chain. It transfers two mannoses into the position 3 of the...; Region: GT1_mtfB_like; cd03809
195102007057	spore coat protein, CotS family; Region: spore_CotS; TIGR02906
195102007058	Aminoglycoside 3'-phosphotransferase (APH) and Choline Kinase (ChoK) family. The APH/ChoK family is part of a larger superfamily that includes the catalytic domains of other kinases, such as the typical serine/threonine/tyrosine protein kinases (PKs)...; Region: APH_ChoK_like; cl17270
195102007059	active site
195102007060	ATP binding site [chemical binding]; other site
195102007061	Aminoglycoside 3'-phosphotransferase (APH) and Choline Kinase (ChoK) family. The APH/ChoK family is part of a larger superfamily that includes the catalytic domains of other kinases, such as the typical serine/threonine/tyrosine protein kinases (PKs)...; Region: APH_ChoK_like; cd05120
195102007062	substrate binding site [chemical binding]; other site
195102007063	spore coat protein, CotS family; Region: spore_CotS; TIGR02906
195102007064	Aminoglycoside 3'-phosphotransferase (APH) and Choline Kinase (ChoK) family. The APH/ChoK family is part of a larger superfamily that includes the catalytic domains of other kinases, such as the typical serine/threonine/tyrosine protein kinases (PKs)...; Region: APH_ChoK_like; cl17270
195102007065	active site
195102007066	ATP binding site [chemical binding]; other site
195102007067	This family is most closely related to the GT1 family of glycosyltransferases. mtfB (mannosyltransferase B) in E. coli has been shown to direct the growth of the O9-specific polysaccharide chain. It transfers two mannoses into the position 3 of the...; Region: GT1_mtfB_like; cd03809
195102007068	Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438
195102007069	Heptaprenyl diphosphate synthase component I; Region: Hpre_diP_synt_I; pfam07456
195102007070	Listerrria innocua Lin0431  is similar to the N-Utilization Substance G (NusG) N terminal (NGN) insert (DII); Region: Lin0431_like; cd09911
195102007071	trimer interface [polypeptide binding]; other site
195102007072	Major membrane immunogen, membrane-anchored lipoprotein [Function unknown]; Region: COG4939
195102007073	FMN-binding domain; Region: FMN_bind; cl01081
195102007074	Membrane-associated lipoprotein involved in thiamine biosynthesis [Coenzyme metabolism]; Region: ApbE; COG1477
195102007075	ApbE family; Region: ApbE; pfam02424
195102007076	ethanolamine utilization protein EutH; Provisional; Region: PRK15086
195102007077	PTS_IIB_chitobiose_lichenan: subunit IIB of enzyme II (EII) of the N,N-diacetylchitobiose-specific and lichenan-specific phosphoenolpyruvate:carbohydrate phosphotransferase system (PTS). In these systems, EII is either a lichenan- or an N; Region: PTS_IIB_chitobiose_lichenan; cd05564
195102007078	active site
195102007079	P-loop; other site
195102007080	phosphorylation site [posttranslational modification]
195102007081	periplasmic serine pepetdase DegS; Region: protease_degS; TIGR02038
195102007082	Trypsin-like peptidase domain; Region: Trypsin_2; pfam13365
195102007083	PDZ domain of tryspin-like serine proteases, such as DegP/HtrA, which are oligomeric proteins involved in heat-shock response, chaperone function, and apoptosis. May be responsible for substrate recognition and/or binding, as most PDZ domains bind...; Region: PDZ_serine_protease; cd00987
195102007084	protein binding site [polypeptide binding]; other site
195102007085	Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697
195102007086	UGMP family protein; Validated; Region: PRK09604
195102007087	Inactive homolog of metal-dependent proteases, putative molecular chaperone [Posttranslational modification, protein turnover, chaperones]; Region: COG1214; cl17884
195102007088	Endodeoxyribonuclease RusA; Region: RusA; pfam05866
195102007089	Members of the SGNH-hydrolase superfamily, a diverse family of lipases and esterases. The tertiary fold of the enzyme is substantially different from that of the alpha/beta hydrolase family and unique among all known hydrolases; its active site closely...; Region: SGNH_hydrolase_like_4; cd04501
195102007090	active site
195102007091	catalytic triad [active]
195102007092	oxyanion hole [active]
195102007093	Thioredoxin reductase [Posttranslational modification, protein turnover, chaperones]; Region: TrxB; COG0492
195102007094	NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500
195102007095	SirA_like_N, a protein of unknown function with an N-terminal SirA-like domain.  The SirA, YedF, YeeD protein family is present in bacteria as well as archaea. SirA (also known as UvrY,  and YhhP) belongs to a family of a two-component response...; Region: SirA_like_N; cd03421
195102007096	selenium metabolism protein YedF; Region: selenium_YedF; TIGR03527
195102007097	CPxP  motif; other site
195102007098	DsrE/DsrF-like family; Region: DrsE; pfam02635
195102007099	Phosphoglycerol transferase and related proteins, alkaline phosphatase superfamily [Cell envelope biogenesis, outer membrane]; Region: MdoB; COG1368
195102007100	Sulfatase; Region: Sulfatase; pfam00884
195102007101	Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642
195102007102	Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225
195102007103	dimerization interface [polypeptide binding]; other site
195102007104	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
195102007105	dimer interface [polypeptide binding]; other site
195102007106	phosphorylation site [posttranslational modification]
195102007107	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
195102007108	ATP binding site [chemical binding]; other site
195102007109	Mg2+ binding site [ion binding]; other site
195102007110	G-X-G motif; other site
195102007111	Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745
195102007112	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
195102007113	active site
195102007114	dimerization interface [polypeptide binding]; other site
195102007115	Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383
195102007116	DNA binding site [nucleotide binding]
195102007117	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
195102007118	PEP synthetase regulatory protein; Provisional; Region: PRK05339
195102007119	Methyltransferase domain; Region: Methyltransf_31; pfam13847
195102007120	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
195102007121	S-adenosylmethionine binding site [chemical binding]; other site
195102007122	Signal peptidase (SPase) II; Region: Peptidase_A8; cl00458
195102007123	Bacterial extracellular solute-binding protein; Region: SBP_bac_1; cl17199
195102007124	Bacterial extracellular solute-binding protein; Region: SBP_bac_1; cl17199
195102007125	Chromate transporter; Region: Chromate_transp; pfam02417
195102007126	Chromate transporter; Region: Chromate_transp; pfam02417
195102007127	Domain of unknown function (DUF4309); Region: DUF4309; pfam14172
195102007128	Xaa-His dipeptidase; Region: aa-his-dipept; TIGR01893
195102007129	M20 Peptidase D has specificity for beta-alanyl-L-histidine dipeptide; Region: M20_pepD; cd03890
195102007130	metal binding site [ion binding]; metal-binding site
195102007131	dimer interface [polypeptide binding]; other site
195102007132	Escherichia coli YfcE and related proteins, metallophosphatase domain; Region: MPP_YfcE; cd00841
195102007133	Calcineurin-like phosphoesterase; Region: Metallophos; pfam00149
195102007134	active site
195102007135	metal binding site [ion binding]; metal-binding site
195102007136	homotetramer interface [polypeptide binding]; other site
195102007137	NTPase/HAM1.  This family consists of the HAM1 protein and pyrophosphate-releasing xanthosine/ inosine triphosphatase. HAM1 protects the cell against mutagenesis by the base analog 6-N-hydroxylaminopurine (HAP) in E. Coli and S. cerevisiae. A...; Region: HAM1; cd00515
195102007138	active site
195102007139	dimerization interface [polypeptide binding]; other site
195102007140	ribonuclease PH; Reviewed; Region: rph; PRK00173
195102007141	Ribonuclease PH; Region: RNase_PH_bact; cd11362
195102007142	hexamer interface [polypeptide binding]; other site
195102007143	active site
195102007144	The substrate-binding domain of an ABC-type nickel/oligopeptide-like import system contains the type 2 periplasmic binding fold; Region: PBP2_NikA_DppA_OppA_like; cl01709
195102007145	Bacterial extracellular solute-binding proteins, family 5 Middle; Region: SBP_bac_5; pfam00496
195102007146	Restriction endonuclease; Region: Mrr_cat; pfam04471
195102007147	NAD-dependent DNA ligase LigA; Validated; Region: ligA; PRK07956
195102007148	NAD+ dependent DNA ligase adenylation domain. DNA ligases catalyze the crucial step of joining the breaks in duplex DNA during DNA replication, repair and recombination, utilizing either ATP or NAD(+) as a cofactor, but using the same basic reaction...; Region: LIGANc; cd00114
195102007149	nucleotide binding pocket [chemical binding]; other site
195102007150	K-X-D-G motif; other site
195102007151	catalytic site [active]
195102007152	NAD-dependent DNA ligase OB-fold domain; Region: DNA_ligase_OB; pfam03120
195102007153	NAD-dependent DNA ligase C4 zinc finger domain; Region: DNA_ligase_ZBD; pfam03119
195102007154	H3TH domains of structure-specific 5' nucleases (or flap endonuclease-1-like) involved in DNA replication, repair, and recombination; Region: H3TH_StructSpec-5'-nucleases; cl14815
195102007155	DNA binding site [nucleotide binding]
195102007156	endonuclease III; includes endonuclease III (DNA-(apurinic or apyrimidinic site) lyase), alkylbase DNA glycosidases (Alka-family) and other DNA glycosidases; Region: ENDO3c; cl14786
195102007157	Breast Cancer Suppressor Protein (BRCA1), carboxy-terminal domain. The BRCT domain is found within many DNA damage repair and cell cycle checkpoint proteins. The unique diversity of this domain superfamily allows BRCT modules to interact forming homo...; Region: BRCT; cd00027
195102007158	Dimer interface [polypeptide binding]; other site
195102007159	BRCT sequence motif; other site
195102007160	ATP-dependent DNA helicase PcrA; Region: pcrA; TIGR01073
195102007161	Part of AAA domain; Region: AAA_19; pfam13245
195102007162	AAA domain; Region: AAA_14; pfam13173
195102007163	Family description; Region: UvrD_C_2; pfam13538
195102007164	Gram positive anchor; Region: Gram_pos_anchor; pfam00746
195102007165	S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site;  Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165
195102007166	16S rRNA pseudouridylate synthase A; Provisional; Region: PRK10839
195102007167	RNA binding surface [nucleotide binding]; other site
195102007168	Pseudouridine synthase, Escherichia coli RsuA like; Region: PseudoU_synth_RsuA; cd02553
195102007169	active site
195102007170	uracil binding [chemical binding]; other site
195102007171	triple tyrosine motif-containing protein; Provisional; Region: PRK14081
195102007172	Y_Y_Y domain; Region: Y_Y_Y; pfam07495
195102007173	Y_Y_Y domain; Region: Y_Y_Y; pfam07495
195102007174	Y_Y_Y domain; Region: Y_Y_Y; pfam07495
195102007175	Y_Y_Y domain; Region: Y_Y_Y; pfam07495
195102007176	Y_Y_Y domain; Region: Y_Y_Y; pfam07495
195102007177	hypothetical protein; Validated; Region: PRK00124
195102007178	glucose-6-phosphate isomerase; Provisional; Region: pgi; PRK14097
195102007179	Phosphoglucose isomerase (PGI) contains two SIS (Sugar ISomerase) domains. This classification is based on the alignment of the first SIS domain. PGI is a multifunctional enzyme which as an intracellular dimer catalyzes the reversible isomerization of...; Region: SIS_PGI_1; cd05015
195102007180	active site
195102007181	dimer interface [polypeptide binding]; other site
195102007182	Phosphoglucose isomerase (PGI) contains two SIS (Sugar ISomerase) domains. This classification is based on the alignment of the second SIS domain. PGI is a multifunctional enzyme which as an intracellular dimer catalyzes the reversible isomerization of...; Region: SIS_PGI_2; cd05016
195102007183	dimer interface [polypeptide binding]; other site
195102007184	active site
195102007185	dipeptide transporter ATP-binding subunit; Provisional; Region: dppF; PRK11308
195102007186	ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257
195102007187	Walker A/P-loop; other site
195102007188	ATP binding site [chemical binding]; other site
195102007189	Q-loop/lid; other site
195102007190	ABC transporter signature motif; other site
195102007191	Walker B; other site
195102007192	D-loop; other site
195102007193	H-loop/switch region; other site
195102007194	oligopeptide/dipeptide ABC transporter, ATP-binding protein, C-terminal domain; Region: oligo_HPY; TIGR01727
195102007195	ABC-type dipeptide/oligopeptide/nickel transport system, ATPase component [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppD; COG0444
195102007196	ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257
195102007197	Walker A/P-loop; other site
195102007198	ATP binding site [chemical binding]; other site
195102007199	Q-loop/lid; other site
195102007200	ABC transporter signature motif; other site
195102007201	Walker B; other site
195102007202	D-loop; other site
195102007203	H-loop/switch region; other site
195102007204	oligopeptide/dipeptide ABC transporter, ATP-binding protein, C-terminal domain; Region: oligo_HPY; TIGR01727
195102007205	N-terminal TM domain of oligopeptide transport permease C; Region: OppC_N; pfam12911
195102007206	ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppC; COG1173
195102007207	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
195102007208	dimer interface [polypeptide binding]; other site
195102007209	conserved gate region; other site
195102007210	putative PBP binding loops; other site
195102007211	ABC-ATPase subunit interface; other site
195102007212	ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppB; COG0601
195102007213	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
195102007214	dimer interface [polypeptide binding]; other site
195102007215	conserved gate region; other site
195102007216	putative PBP binding loops; other site
195102007217	ABC-ATPase subunit interface; other site
195102007218	ABC-type dipeptide transport system, periplasmic component [Amino acid transport and metabolism]; Region: DdpA; COG0747
195102007219	The substrate-binding domain of an ABC-type nickel/oligopeptide-like import system contains the type 2 periplasmic binding fold; Region: PBP2_NikA_DppA_OppA_like; cl01709
195102007220	nitrite extrusion protein (nitrite facilitator); Region: 2A0108; TIGR00886
195102007221	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cl17904
195102007222	GMP synthase; Reviewed; Region: guaA; PRK00074
195102007223	Type 1 glutamine amidotransferase (GATase1) domain found in GMP synthetase; Region: GATase1_GMP_Synthase; cd01742
195102007224	AMP/PPi binding site [chemical binding]; other site
195102007225	candidate oxyanion hole; other site
195102007226	catalytic triad [active]
195102007227	potential glutamine specificity residues [chemical binding]; other site
195102007228	The C-terminal domain of GMP synthetase. It contains two subdomains; the ATP pyrophosphatase domain which closes to the N-termial and the dimerization domain at C-terminal end. The ATP-PPase is a twisted, five-stranded parallel beta-sheet sandwiched...; Region: GMP_synthase_C; cd01997
195102007229	ATP Binding subdomain [chemical binding]; other site
195102007230	Ligand Binding sites [chemical binding]; other site
195102007231	Dimerization subdomain; other site
195102007232	inosine 5'-monophosphate dehydrogenase; Reviewed; Region: PRK05567
195102007233	TIM barrel proteins share a structurally conserved phosphate binding motif and in general share an eight beta/alpha closed barrel structure. Specific for this family is the conserved phosphate binding site at the edges of strands 7 and 8. The phosphate...; Region: TIM_phosphate_binding; cl17186
195102007234	This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains in the inosine 5' monophosphate dehydrogenase (IMPDH) protein.  IMPDH is an essential enzyme that catalyzes the first step unique to GTP synthesis, playing a...; Region: CBS_pair_IMPDH; cd04601
195102007235	IMPDH: The catalytic domain of the inosine monophosphate dehydrogenase. IMPDH catalyzes the NAD-dependent oxidation of inosine 5'-monophosphate (IMP) to xanthosine 5' monophosphate (XMP). It is a rate-limiting step in the de novo synthesis of...; Region: IMPDH; cd00381
195102007236	active site
195102007237	PA14 domain; Region: PA14; cl08459
195102007238	Type IV pilin N-term methylation site GFxxxE; Region: N_methyl_2; cl06830
195102007239	Type II secretory pathway, pseudopilin PulG [Cell motility and secretion / Intracellular trafficking and secretion]; Region: PulG; COG2165
195102007240	Type II secretory pathway, pseudopilin PulG [Cell motility and secretion / Intracellular trafficking and secretion]; Region: PulG; COG2165
195102007241	Type IV pilin N-term methylation site GFxxxE; Region: N_methyl_2; pfam13544
195102007242	Fimbrial assembly protein (PilN); Region: PilN; pfam05137
195102007243	Competence protein A; Region: Competence_A; pfam11104
195102007244	Cell division protein FtsA; Region: FtsA; pfam14450
195102007245	Type II secretory pathway, component PulF [Cell motility and secretion / Intracellular trafficking and secretion]; Region: PulF; COG1459
195102007246	Type II secretion system (T2SS), protein F; Region: T2SF; pfam00482
195102007247	Type II secretion system (T2SS), protein F; Region: T2SF; pfam00482
195102007248	type IV-A pilus assembly ATPase PilB; Region: type_IV_pilB; TIGR02538
195102007249	Type II secretion system (T2SS), protein E, N-terminal domain; Region: T2SE_Nter; pfam05157
195102007250	PulE/GspE The type II secretory pathway is the main terminal branch of the general secretory pathway (GSP). It is responsible for the export the majority of Gram-negative bacterial exoenzymes and toxins. PulE is a cytoplasmic protein of the GSP, which...; Region: PulE-GspE; cd01129
195102007251	Walker A motif; other site
195102007252	ATP binding site [chemical binding]; other site
195102007253	Walker B motif; other site
195102007254	Type II secretory pathway, prepilin signal peptidase PulO and related peptidases [Cell motility and secretion / Posttranslational modification, protein turnover, chaperones / Intracellular trafficking and secretion]; Region: PulO; COG1989
195102007255	Bacterial Peptidase A24 N-terminal domain; Region: DiS_P_DiS; pfam06750
195102007256	Type IV leader peptidase family; Region: Peptidase_A24; pfam01478
195102007257	chaperonin GroEL; Reviewed; Region: groEL; PRK12849
195102007258	GroEL_like type I chaperonin. Chaperonins are involved in productive folding of proteins. They share a common general morphology, a double toroid of 2 stacked rings, each composed of 7-9 subunits. The symmetry of type I is seven-fold and they are found...; Region: GroEL; cd03344
195102007259	ring oligomerisation interface [polypeptide binding]; other site
195102007260	ATP/Mg binding site [chemical binding]; other site
195102007261	stacking interactions; other site
195102007262	hinge regions; other site
195102007263	Chaperonin 10 Kd subunit (cpn10 or GroES); Cpn10 cooperates with chaperonin 60 (cpn60 or GroEL), an ATPase, to assist the folding and assembly of proteins and is found in eubacterial cytosol, as well as in the matrix of mitochondria and chloroplasts. It...; Region: cpn10; cd00320
195102007264	oligomerisation interface [polypeptide binding]; other site
195102007265	mobile loop; other site
195102007266	roof hairpin; other site
195102007267	Protein of unknown function (DUF1461); Region: DUF1461; pfam07314
195102007268	HNH nucleases; HNH endonuclease signature which is found in viral, prokaryotic, and eukaryotic proteins. The alignment includes members of the large group of homing endonucleases, yeast intron 1 protein, MutS, as well as bacterial colicins, pyocins, and...; Region: HNHc; cl00083
195102007269	active site
195102007270	8-oxoguanine DNA glycosylase, N-terminal domain; Region: OGG_N; pfam07934
195102007271	8-oxoguanine DNA-glycosylase (ogg); Region: ogg; TIGR00588
195102007272	endonuclease III; includes endonuclease III (DNA-(apurinic or apyrimidinic site) lyase), alkylbase DNA glycosidases (Alka-family) and other DNA glycosidases; Region: ENDO3c; cd00056
195102007273	minor groove reading motif; other site
195102007274	helix-hairpin-helix signature motif; other site
195102007275	substrate binding pocket [chemical binding]; other site
195102007276	active site
195102007277	C_GCAxxG_C_C family probable redox protein; Region: C_GCAxxG_C_C; TIGR01909
195102007278	The S26 Type I signal peptidase (SPase; LepB; leader peptidase B; leader peptidase I; EC 3.4.21.89) family members are essential membrane-bound serine proteases that function to cleave the amino-terminal signal peptide extension from proteins that are...; Region: S26_SPase_I; cd06530
195102007279	Catalytic site [active]
195102007280	ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132
195102007281	ABC transporter transmembrane region; Region: ABC_membrane; pfam00664
195102007282	ATP-binding cassette domain of the bacterial lipid flippase and related proteins, subfamily C; Region: ABCC_MsbA; cd03251
195102007283	Walker A/P-loop; other site
195102007284	ATP binding site [chemical binding]; other site
195102007285	Q-loop/lid; other site
195102007286	ABC transporter signature motif; other site
195102007287	Walker B; other site
195102007288	D-loop; other site
195102007289	H-loop/switch region; other site
195102007290	3-hydroxybutyryl-CoA dehydrogenase; Validated; Region: PRK05808
195102007291	3-hydroxyacyl-CoA dehydrogenase, NAD binding domain; Region: 3HCDH_N; pfam02737
195102007292	3-hydroxyacyl-CoA dehydrogenase, C-terminal domain; Region: 3HCDH; pfam00725
195102007293	Electron transfer flavoprotein, alpha subunit [Energy production and conversion]; Region: FixB; COG2025
195102007294	The electron transfer flavoprotein (ETF) serves as a specific electron acceptor for various mitochondrial dehydrogenases. ETF transfers electrons to the main respiratory chain via ETF-ubiquinone oxidoreductase. ETF is an heterodimer that consists of an...; Region: ETF_alpha; cd01715
195102007295	Electron transfer flavoprotein FAD-binding domain; Region: ETF_alpha; pfam00766
195102007296	The electron transfer flavoprotein (ETF) serves as a specific electron acceptor for various mitochondrial dehydrogenases. ETF transfers electrons to the main respiratory chain via ETF-ubiquinone oxidoreductase. ETF is an heterodimer that consists of an...; Region: ETF_beta; cd01714
195102007297	Ligand binding site [chemical binding]; other site
195102007298	Electron transfer flavoprotein domain; Region: ETF; pfam01012
195102007299	Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960
195102007300	Short chain acyl-CoA dehydrogenases and eukaryotic short/branched chain acyl-CoA dehydrogenases; Region: SCAD_SBCAD; cd01158
195102007301	FAD binding site [chemical binding]; other site
195102007302	homotetramer interface [polypeptide binding]; other site
195102007303	substrate binding pocket [chemical binding]; other site
195102007304	catalytic base [active]
195102007305	3-hydroxybutyryl-CoA dehydratase; Validated; Region: PRK05809
195102007306	Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558
195102007307	substrate binding site [chemical binding]; other site
195102007308	oxyanion hole (OAH) forming residues; other site
195102007309	trimer interface [polypeptide binding]; other site
195102007310	redox-sensing transcriptional repressor Rex; Provisional; Region: PRK05472
195102007311	Putative DNA-binding protein N-terminus; Region: Put_DNA-bind_N; pfam06971
195102007312	CoA binding domain; Region: CoA_binding; pfam02629
195102007313	Heavy-metal-associated domain; Region: HMA; pfam00403
195102007314	metal-binding site [ion binding]
195102007315	heavy metal-(Cd/Co/Hg/Pb/Zn)-translocating P-type ATPase; Region: ATPase-IB2_Cd; TIGR01512
195102007316	E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122
195102007317	Soluble P-type ATPase [General function prediction only]; Region: COG4087
195102007318	Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090
195102007319	dimerization interface [polypeptide binding]; other site
195102007320	putative DNA binding site [nucleotide binding]; other site
195102007321	putative Zn2+ binding site [ion binding]; other site
195102007322	Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377
195102007323	DNA-binding site [nucleotide binding]; DNA binding site
195102007324	TrkA-C domain; Region: TrkA_C; pfam02080
195102007325	Zinc dependent phospholipase C; Region: Zn_dep_PLPC; pfam00882
195102007326	Protein of unknown function (DUF3867); Region: DUF3867; pfam12983
195102007327	Mannose-1-phosphate guanylyltransferase [Cell envelope biogenesis, outer membrane]; Region: {ManC}; COG0836
195102007328	GDP-M1P_Guanylyltransferase catalyzes the formation of GDP-Mannose; Region: GDP-M1P_Guanylyltransferase; cd02509
195102007329	Substrate binding site; other site
195102007330	Cupin domain; Region: Cupin_2; cl17218
195102007331	Beta-glucosidase/6-phospho-beta-glucosidase/beta- galactosidase [Carbohydrate transport and metabolism]; Region: BglB; COG2723
195102007332	beta-galactosidase; Region: BGL; TIGR03356
195102007333	Bacillus subtilis aldehyde dehydrogenase ywdH-like; Region: ALDH_YwdH-P39616; cd07136
195102007334	aldehyde dehydrogenase family protein; Provisional; Region: PTZ00381
195102007335	NAD(P) binding site [chemical binding]; other site
195102007336	catalytic residues [active]
195102007337	Domain of unknown function (DUF4163); Region: DUF4163; pfam13739
195102007338	Protein of unknown function (DUF3298); Region: DUF3298; pfam11738
195102007339	Alpha/beta hydrolase family; Region: Abhydrolase_5; pfam12695
195102007340	16S rRNA uridine-516 pseudouridylate synthase and related pseudouridylate synthases [Translation, ribosomal structure and biogenesis]; Region: RsuA; COG1187
195102007341	S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site;  Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165
195102007342	RNA binding surface [nucleotide binding]; other site
195102007343	Pseudouridine synthase, Escherichia coli RluF like; Region: PseudoU_synth_RluF; cd02554
195102007344	probable active site [active]
195102007345	Anti-sigma factor N-terminus; Region: RsgI_N; pfam12791
195102007346	Sortase D (SrtD) is a membrane transpeptidase found in gram-positive bacteria that anchors surface proteins to peptidoglycans of the bacterial cell wall envelope. This involves a transpeptidation reaction in which the surface protein substrate is cleaved...; Region: Sortase_D_5; cd06166
195102007347	active site
195102007348	catalytic site [active]
195102007349	MECDP_synthase (2-C-methyl-D-erythritol-2,4-cyclodiphosphate synthase), encoded by the ispF gene, catalyzes the formation of 2-C-methyl-D-erythritol 2,4-cyclodiphosphate (MEC) in the non-mevalonate deoxyxylulose (DOXP) pathway for isoprenoid biosynthesis; Region: MECDP_synthase; cd00554
195102007350	homotrimer interaction site [polypeptide binding]; other site
195102007351	zinc binding site [ion binding]; other site
195102007352	CDP-binding sites; other site
195102007353	Na+/H+ antiporter [Energy production and conversion]; Region: NhaC; COG1757
195102007354	Pyridoxal kinase plays a key role in the synthesis of the active coenzyme pyridoxal-5'-phosphate  (PLP), by catalyzing the phosphorylation of the precursor vitamin B6  in the presence of Zn2+ and ATP. Mammals are unable to synthesize PLP de novo and...; Region: pyridoxal_pyridoxamine_kinase; cd01173
195102007355	dimer interface [polypeptide binding]; other site
195102007356	pyridoxal binding site [chemical binding]; other site
195102007357	ATP binding site [chemical binding]; other site
195102007358	HNH nucleases; HNH endonuclease signature which is found in viral, prokaryotic, and eukaryotic proteins. The alignment includes members of the large group of homing endonucleases, yeast intron 1 protein, MutS, as well as bacterial colicins, pyocins, and...; Region: HNHc; cd00085
195102007359	active site
195102007360	SGNH_hydrolase, or GDSL_hydrolase, is a diverse family of lipases and esterases. The tertiary fold of the enzyme is substantially different from that of the alpha/beta hydrolase family and unique among all known hydrolases; its active site closely...; Region: SGNH_hydrolase; cd00229
195102007361	active site
195102007362	catalytic triad [active]
195102007363	oxyanion hole [active]
195102007364	SGNH_hydrolase, or GDSL_hydrolase, is a diverse family of lipases and esterases. The tertiary fold of the enzyme is substantially different from that of the alpha/beta hydrolase family and unique among all known hydrolases; its active site closely...; Region: SGNH_hydrolase; cd00229
195102007365	active site
195102007366	catalytic triad [active]
195102007367	oxyanion hole [active]
195102007368	threonyl-tRNA synthetase; Reviewed; Region: thrS; PRK00413
195102007369	TGS _ThrRS_N:  ThrRS (threonyl-tRNA Synthetase)  is a class II tRNA synthetase that couples threonine to its cognate tRNA.  In addition to its catalytic and anticodon-binding domains, ThrRS has an N-terminal TGS domain, named after the ThrRS, GTPase, and...; Region: TGS_ThrRS_N; cd01667
195102007370	Threonyl and Alanyl tRNA synthetase second additional domain; Region: tRNA_SAD; pfam07973
195102007371	Threonyl-tRNA synthetase (ThrRS) class II core catalytic domain. ThrRS is a homodimer. It is responsible for the attachment of threonine to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for ATP-dependent...; Region: ThrRS_core; cd00771
195102007372	active site
195102007373	dimer interface [polypeptide binding]; other site
195102007374	motif 1; other site
195102007375	motif 2; other site
195102007376	motif 3; other site
195102007377	ThrRS Threonyl-anticodon binding domain. ThrRS belongs to class II aminoacyl-tRNA synthetases (aaRS). This alignment contains the anticodon binding domain, which is responsible for specificity in tRNA-binding, so that the activated amino acid is...; Region: ThrRS_anticodon; cd00860
195102007378	anticodon binding site; other site
195102007379	Peptidase family M3B Oligopeptidase F (PepF); Region: M3B_PepF_1; cd09606
195102007380	oligoendopeptidase, M3 family; Region: M3_not_pepF; TIGR02289
195102007381	active site
195102007382	Zn binding site [ion binding]; other site
195102007383	5-formyltetrahydrofolate cyclo-ligase family; Region: 5-FTHF_cyc-lig; pfam01812
195102007384	5,10-methenyltetrahydrofolate synthetase; Region: MTHFS_bact; TIGR02727
195102007385	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
195102007386	S-adenosylmethionine binding site [chemical binding]; other site
195102007387	glucosamine--fructose-6-phosphate aminotransferase; Reviewed; Region: PRK00331
195102007388	Glutamine amidotransferases class-II (Gn-AT)_GFAT-type. This domain is found at the N-terminus of glucosamine-6P synthase (GlmS, or GFAT in humans).  The glutaminase domain catalyzes amide nitrogen transfer from glutamine to the appropriate substrate. In...; Region: GFAT; cd00714
195102007389	glutaminase active site [active]
195102007390	SIS (Sugar ISomerase) domain repeat 1 found in Glucosamine 6-phosphate synthase (GlmS) and Glucosamine-6-phosphate deaminase (GlmD). The SIS domain is found in many phosphosugar isomerases and phosphosugar binding proteins. GlmS contains a N-terminal...; Region: SIS_GlmS_GlmD_1; cd05008
195102007391	dimer interface [polypeptide binding]; other site
195102007392	active site
195102007393	SIS (Sugar ISomerase) domain repeat 2 found in Glucosamine 6-phosphate synthase (GlmS) and Glucosamine-6-phosphate deaminase (GlmD). The SIS domain is found in many phosphosugar isomerases and phosphosugar binding proteins. GlmS contains a N-terminal...; Region: SIS_GlmS_GlmD_2; cd05009
195102007394	dimer interface [polypeptide binding]; other site
195102007395	active site
195102007396	Ferritin-like superfamily of diiron-containing four-helix-bundle proteins; Region: Ferritin_like; cd00657
195102007397	dinuclear metal binding motif [ion binding]; other site
195102007398	phosphoglucosamine mutase; Provisional; Region: glmM; PRK14316
195102007399	GlmM is a bacterial phosphoglucosamine mutase (PNGM) that belongs to the alpha-D-phosphohexomutase superfamily. It is required for the interconversion of glucosamine-6-phosphate and glucosamine-1-phosphate in the biosynthetic pathway of...; Region: GlmM; cd05802
195102007400	active site
195102007401	substrate binding site [chemical binding]; other site
195102007402	metal binding site [ion binding]; metal-binding site
195102007403	Domain of Unknown Function (DUF349); Region: DUF349; pfam03993
195102007404	Domain of Unknown Function (DUF349); Region: DUF349; pfam03993
195102007405	Domain of Unknown Function (DUF349); Region: DUF349; pfam03993
195102007406	HAMP domain; Region: HAMP; pfam00672
195102007407	Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642
195102007408	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
195102007409	dimer interface [polypeptide binding]; other site
195102007410	phosphorylation site [posttranslational modification]
195102007411	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
195102007412	ATP binding site [chemical binding]; other site
195102007413	Mg2+ binding site [ion binding]; other site
195102007414	G-X-G motif; other site
195102007415	Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745
195102007416	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
195102007417	active site
195102007418	phosphorylation site [posttranslational modification]
195102007419	intermolecular recognition site; other site
195102007420	dimerization interface [polypeptide binding]; other site
195102007421	Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383
195102007422	DNA binding site [nucleotide binding]
195102007423	Domain of Unknown Function (DUF1540); Region: DUF1540; pfam07561
195102007424	Domain of Unknown Function (DUF1540); Region: DUF1540; pfam07561
195102007425	Trp repressor protein; Region: Trp_repressor; cl17266
195102007426	Mitochondrial biogenesis AIM24; Region: AIM24; pfam01987
195102007427	Glycogen debranching enzyme N terminal; Region: GDE_N; pfam12439
195102007428	glycogen debranching enzyme, archaeal type, putative; Region: gde_arch; TIGR01561
195102007429	Amylo-alpha-1,6-glucosidase; Region: GDE_C; pfam06202
195102007430	This is a family of oligosaccharide phosphorylases. It includes yeast and mammalian glycogen phosphorylases, plant starch/glucan phosphorylase, as well as the maltodextrin phosphorylases of bacteria. The members of this family catalyze the breakdown of...; Region: GT1_Glycogen_Phosphorylase; cd04300
195102007431	homodimer interface [polypeptide binding]; other site
195102007432	glycogen/starch/alpha-glucan phosphorylases; Region: P_ylase; TIGR02093
195102007433	active site pocket [active]
195102007434	4-alpha-glucanotransferase; Provisional; Region: PRK14508
195102007435	Alpha-glucosidases, family 31 of glycosyl hydrolases [Carbohydrate transport and metabolism]; Region: COG1501
195102007436	Galactose mutarotase-like; Region: Gal_mutarotas_2; pfam13802
195102007437	Alpha-glucosidase II (alpha-D-glucoside glucohydrolase) is a glycosyl hydrolase family 31 (GH31) enzyme, found in bacteria and plants, which has exo-alpha-1,4-glucosidase and oligo-1,6-glucosidase activities. Alpha-glucosidase II has been characterized...; Region: GH31_glucosidase_II_MalA; cd06604
195102007438	trimer interface [polypeptide binding]; other site
195102007439	active site
195102007440	homohexamer (dimer of homotrimer) interface [polypeptide binding]; other site
195102007441	catalytic site [active]
195102007442	Transcriptional regulators [Transcription]; Region: PurR; COG1609
195102007443	Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392
195102007444	DNA binding site [nucleotide binding]
195102007445	domain linker motif; other site
195102007446	Ligand binding domain of the LacI tanscriptional regulator family belonging to the type I periplasmic-binding fold protein superfamily; Region: PBP1_LacI_sugar_binding_like; cd06267
195102007447	dimerization interface [polypeptide binding]; other site
195102007448	ligand binding site [chemical binding]; other site
195102007449	ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395
195102007450	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
195102007451	dimer interface [polypeptide binding]; other site
195102007452	conserved gate region; other site
195102007453	putative PBP binding loops; other site
195102007454	ABC-ATPase subunit interface; other site
195102007455	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
195102007456	dimer interface [polypeptide binding]; other site
195102007457	conserved gate region; other site
195102007458	ABC-ATPase subunit interface; other site
195102007459	Maltose-binding periplasmic proteins/domains [Carbohydrate transport and metabolism]; Region: MalE; COG2182
195102007460	Bacterial extracellular solute-binding protein; Region: SBP_bac_1; pfam01547
195102007461	PucR C-terminal helix-turn-helix domain; Region: HTH_30; pfam13556
195102007462	glycerol-3-phosphate transporter ATP-binding subunit; Provisional; Region: ugpC; PRK11650
195102007463	The N-terminal ATPase domain of the maltose transporter, MalK; Region: ABC_MalK_N; cd03301
195102007464	Walker A/P-loop; other site
195102007465	ATP binding site [chemical binding]; other site
195102007466	Q-loop/lid; other site
195102007467	ABC transporter signature motif; other site
195102007468	Walker B; other site
195102007469	D-loop; other site
195102007470	H-loop/switch region; other site
195102007471	TOBE domain; Region: TOBE; pfam03459
195102007472	2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207
195102007473	catalytic loop [active]
195102007474	iron binding site [ion binding]; other site
195102007475	NADH-ubiquinone oxidoreductase-G iron-sulfur binding region; Region: NADH-G_4Fe-4S_3; smart00929
195102007476	[FeFe] hydrogenase, group A; Region: FeFe_hydrog_A; TIGR02512
195102007477	Iron only hydrogenase large subunit, C-terminal domain; Region: Fe_hyd_lg_C; pfam02906
195102007478	Iron hydrogenase small subunit; Region: Fe_hyd_SSU; pfam02256
195102007479	Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cd00012
195102007480	nucleotide binding site [chemical binding]; other site
195102007481	Acetokinase family; Region: Acetate_kinase; cl17229
195102007482	phosphate butyryltransferase; Validated; Region: PRK05805
195102007483	Uncharacterized FAD-dependent dehydrogenases [General function prediction only]; Region: COG2509
195102007484	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4856
195102007485	YbbR-like protein; Region: YbbR; pfam07949
195102007486	TIGR00159 family protein; Region: TIGR00159
195102007487	DisA bacterial checkpoint controller nucleotide-binding; Region: DisA_N; pfam02457
195102007488	Cell Wall Hydrolase; Region: Hydrolase_2; pfam07486
195102007489	Thioredoxin reductase [Posttranslational modification, protein turnover, chaperones]; Region: TrxB; COG0492
195102007490	TRX family; composed of two groups: Group I, which includes proteins that exclusively encode a TRX domain; and Group II, which are composed of fusion proteins of TRX and additional domains. Group I TRX is a small ancient protein that alter the redox...; Region: TRX_family; cd02947
195102007491	Thioredoxin-like; Region: Thioredoxin_8; pfam13905
195102007492	catalytic residues [active]
195102007493	Isoaspartyl dipeptidase hydrolyzes the beta-L-isoaspartyl linkages in dipeptides, as part of the degradative pathway to eliminate proteins with beta-L-isoaspartyl peptide bonds, bonds whereby the beta-group of an aspartate forms the peptide link with the...; Region: Isoaspartyl-dipeptidase; cd01308
195102007494	isoaspartyl dipeptidase IadA; Region: isoAsp_dipep; TIGR01975
195102007495	dimer interface [polypeptide binding]; other site
195102007496	active site
195102007497	Phosphoenolpyruvate-protein kinase (PTS system EI component in bacteria) [Carbohydrate transport and metabolism]; Region: PtsA; COG1080
195102007498	PEP-utilising enzyme, N-terminal; Region: PEP-utilisers_N; pfam05524
195102007499	PEP-utilising enzyme, mobile domain; Region: PEP-utilizers; pfam00391
195102007500	PEP-utilising enzyme, TIM barrel domain; Region: PEP-utilizers_C; pfam02896
195102007501	Histidine-containing phosphocarrier protein (HPr)-like proteins. HPr is a central component of the bacterial phosphoenolpyruvate sugar phosphotransferase system (PTS). The PTS catalyses the phosphorylation of sugar substrates during their translocation...; Region: PTS-HPr_like; cd00367
195102007502	dimerization domain swap beta strand [polypeptide binding]; other site
195102007503	regulatory protein interface [polypeptide binding]; other site
195102007504	active site
195102007505	regulatory phosphorylation site [posttranslational modification]; other site
195102007506	Transcriptional regulator containing PAS, AAA-type ATPase, and DNA-binding domains [Transcription / Signal transduction mechanisms]; Region: RocR; COG3829
195102007507	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
195102007508	putative active site [active]
195102007509	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
195102007510	Walker A motif; other site
195102007511	ATP binding site [chemical binding]; other site
195102007512	Walker B motif; other site
195102007513	arginine finger; other site
195102007514	Bacterial regulatory protein, Fis family; Region: HTH_8; cl17420
195102007515	30S ribosomal protein S4; Validated; Region: rpsD; PRK05327
195102007516	Ribosomal protein S4/S9 N-terminal domain; Region: Ribosomal_S4; pfam00163
195102007517	S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site;  Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165
195102007518	RNA binding surface [nucleotide binding]; other site
195102007519	Ribonucleotide Reductase, R2/beta subunit, ferritin-like diiron-binding domain; Region: RNRR2; cd01049
195102007520	dimer interface [polypeptide binding]; other site
195102007521	putative radical transfer pathway; other site
195102007522	diiron center [ion binding]; other site
195102007523	tyrosyl radical; other site
195102007524	ribonucleotide-diphosphate reductase subunit alpha; Validated; Region: PRK07088
195102007525	Class I ribonucleotide reductase; Region: RNR_I; cd01679
195102007526	active site
195102007527	dimer interface [polypeptide binding]; other site
195102007528	catalytic residues [active]
195102007529	effector binding site; other site
195102007530	R2 peptide binding site; other site
195102007531	Arsenate Reductase (ArsC) family, unknown subfamily; uncharacterized proteins containing a CXXC motif with similarity to thioredoxin (TRX)-fold arsenic reductases, ArsC. Proteins containing a redox active CXXC motif like TRX and glutaredoxin (GRX)...; Region: ArsC_like; cd03036
195102007532	ArsC family; Region: ArsC; pfam03960
195102007533	putative ArsC-like catalytic residues; other site
195102007534	putative TRX-like catalytic residues [active]
195102007535	Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642
195102007536	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
195102007537	dimer interface [polypeptide binding]; other site
195102007538	phosphorylation site [posttranslational modification]
195102007539	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
195102007540	ATP binding site [chemical binding]; other site
195102007541	Mg2+ binding site [ion binding]; other site
195102007542	G-X-G motif; other site
195102007543	Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745
195102007544	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
195102007545	active site
195102007546	phosphorylation site [posttranslational modification]
195102007547	intermolecular recognition site; other site
195102007548	dimerization interface [polypeptide binding]; other site
195102007549	Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383
195102007550	DNA binding site [nucleotide binding]
195102007551	Uncharacterized conserved protein [Function unknown]; Region: COG1284
195102007552	Uncharacterized BCR, YitT family COG1284; Region: DUF161; pfam02588
195102007553	Uncharacterized BCR, YitT family COG1284; Region: DUF161; pfam02588
195102007554	Uncharacterized protein conserved in bacteria (DUF2179); Region: DUF2179; pfam10035
195102007555	N-acetylmuramoyl-L-alanine amidase [Cell envelope biogenesis, outer membrane]; Region: AmiC; COG0860
195102007556	N-acetylmuramoyl-L-alanine amidase or MurNAc-LAA (also known as peptidoglycan aminohydrolase, NAMLA amidase, NAMLAA, Amidase 3, and peptidoglycan amidase; EC 3.5.1.28) is an autolysin that hydrolyzes the amide bond between N-acetylmuramoyl and L-amino...; Region: MurNAc-LAA; cd02696
195102007557	active site
195102007558	metal binding site [ion binding]; metal-binding site
195102007559	Na+/phosphate symporter [Inorganic ion transport and metabolism]; Region: NptA; COG1283
195102007560	Na+/Pi-cotransporter; Region: Na_Pi_cotrans; pfam02690
195102007561	Na+/Pi-cotransporter; Region: Na_Pi_cotrans; pfam02690
195102007562	PhoU domain; Region: PhoU; pfam01895
195102007563	PhoU domain; Region: PhoU; pfam01895
195102007564	30S ribosomal protein S9; Reviewed; Region: rpsI; PRK00132
195102007565	Ribosomal protein L13.  Protein L13, a large ribosomal subunit protein, is one of five proteins required for an early folding intermediate of 23S rRNA in the assembly of the large subunit. L13 is situated on the bottom of the large subunit, near the...; Region: Ribosomal_L13; cd00392
195102007566	23S rRNA interface [nucleotide binding]; other site
195102007567	L3 interface [polypeptide binding]; other site
195102007568	tRNA pseudouridine synthase A; Validated; Region: truA; PRK00021
195102007569	Eukaryotic and bacterial pseudouridine synthases similar to E.  coli TruA; Region: PseudoU_synth_EcTruA; cd02570
195102007570	dimerization interface 3.5A [polypeptide binding]; other site
195102007571	active site
195102007572	ABC-type cobalt transport system, permease component CbiQ and related transporters [Inorganic ion transport and metabolism]; Region: CbiQ; COG0619
195102007573	cobalt transporter ATP-binding subunit; Provisional; Region: cbiO; PRK13637
195102007574	First domain of the ATP-binding cassette component of cobalt transport system; Region: ABC_cobalt_CbiO_domain1; cd03225
195102007575	Walker A/P-loop; other site
195102007576	ATP binding site [chemical binding]; other site
195102007577	Q-loop/lid; other site
195102007578	ABC transporter signature motif; other site
195102007579	Walker B; other site
195102007580	D-loop; other site
195102007581	H-loop/switch region; other site
195102007582	cobalt transporter ATP-binding subunit; Provisional; Region: PRK13633
195102007583	First domain of the ATP-binding cassette component of cobalt transport system; Region: ABC_cobalt_CbiO_domain1; cd03225
195102007584	Walker A/P-loop; other site
195102007585	ATP binding site [chemical binding]; other site
195102007586	Q-loop/lid; other site
195102007587	ABC transporter signature motif; other site
195102007588	Walker B; other site
195102007589	D-loop; other site
195102007590	H-loop/switch region; other site
195102007591	50S ribosomal protein L17; Validated; Region: rplQ; PRK05591
195102007592	DNA-directed RNA polymerase subunit alpha; Provisional; Region: PRK05182
195102007593	N-terminal domain of the Alpha subunit of Bacterial RNA polymerase; Region: RNAP_alpha_NTD; cd06928
195102007594	alphaNTD homodimer interface [polypeptide binding]; other site
195102007595	alphaNTD - beta interaction site [polypeptide binding]; other site
195102007596	alphaNTD - beta' interaction site [polypeptide binding]; other site
195102007597	Bacterial RNA polymerase, alpha chain C terminal domain; Region: RNA_pol_A_CTD; pfam03118
195102007598	30S ribosomal protein S4; Validated; Region: rpsD; PRK05327
195102007599	Ribosomal protein S4/S9 N-terminal domain; Region: Ribosomal_S4; pfam00163
195102007600	S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site;  Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165
195102007601	RNA binding surface [nucleotide binding]; other site
195102007602	30S ribosomal protein S11; Validated; Region: PRK05309
195102007603	30S ribosomal protein S13; Validated; Region: rpsM; PRK05179
195102007604	30S ribosomal protein S13; Region: bact_S13; TIGR03631
195102007605	50S ribosomal protein L36; Reviewed; Region: rpmJ; PRK00465
195102007606	S1_IF1: Translation Initiation Factor IF1, S1-like RNA-binding domain. IF1 contains an S1-like RNA-binding domain, which is found in a wide variety of RNA-associated proteins. Translation initiation includes a number of interrelated steps preceding the...; Region: S1_IF1; cd04451
195102007607	rRNA binding site [nucleotide binding]; other site
195102007608	predicted 30S ribosome binding site; other site
195102007609	KOW motif of Ribosomal Protein L14; Region: KOW_RPL14; cd06088
195102007610	RNA binding site [nucleotide binding]; other site
195102007611	Methionine Aminopeptidase 1. E.C. 3.4.11.18. Also known as methionyl aminopeptidase and Peptidase M. Catalyzes release of N-terminal amino acids, preferentially methionine, from peptides and arylamides; Region: MetAP1; cd01086
195102007612	active site
195102007613	adenylate kinase; Reviewed; Region: adk; PRK00279
195102007614	Adenylate kinase (ADK) catalyzes the reversible phosphoryl transfer from adenosine triphosphates (ATP) to adenosine monophosphates (AMP) and to yield adenosine diphosphates (ADP). This enzyme is required for the biosynthesis of ADP and is essential for...; Region: ADK; cd01428
195102007615	AMP-binding site [chemical binding]; other site
195102007616	ATP-AMP (Ap5A)-binding site [chemical binding]; other site
195102007617	preprotein translocase subunit SecY; Reviewed; Region: secY; PRK09204
195102007618	SecY translocase; Region: SecY; pfam00344
195102007619	50S ribosomal protein L15; Reviewed; Region: rplO; PRK05592
195102007620	Ribosomal protein L30, which is found in eukaryotes and prokaryotes but not in archaea, is one of the smallest ribosomal proteins with a molecular mass of about 7kDa. L30 binds the 23SrRNA as well as the 5S rRNA and is one of five ribosomal proteins that...; Region: Ribosomal_L30; cd01658
195102007621	23S rRNA binding site [nucleotide binding]; other site
195102007622	30S ribosomal protein S5; Validated; Region: rpsE; PRK00550
195102007623	Ribosomal protein S5, N-terminal domain; Region: Ribosomal_S5; pfam00333
195102007624	Ribosomal protein S5, C-terminal domain; Region: Ribosomal_S5_C; pfam03719
195102007625	Ribosomal L18/L5e:  L18 (L5e) is a ribosomal protein found in the central protuberance (CP) of the large subunit. L18 binds 5S rRNA and induces a conformational change that stimulates the binding of L5 to 5S rRNA. Association of 5S rRNA with 23S rRNA...; Region: Ribosomal_L18_L5e; cd00432
195102007626	5S rRNA interface [nucleotide binding]; other site
195102007627	L27 interface [polypeptide binding]; other site
195102007628	23S rRNA interface [nucleotide binding]; other site
195102007629	L5 interface [polypeptide binding]; other site
195102007630	50S ribosomal protein L6; Validated; Region: rplF; PRK05498
195102007631	Ribosomal protein L6; Region: Ribosomal_L6; pfam00347
195102007632	Ribosomal protein L6; Region: Ribosomal_L6; pfam00347
195102007633	30S ribosomal protein S8; Validated; Region: rpsH; PRK00136
195102007634	30S ribosomal protein S14; Reviewed; Region: rpsN; PRK08061
195102007635	50S ribosomal protein L5; Validated; Region: rplE; PRK00010
195102007636	Ribosomal protein L5; Region: Ribosomal_L5; pfam00281
195102007637	ribosomal L5P family C-terminus; Region: Ribosomal_L5_C; pfam00673
195102007638	50S ribosomal protein L24; Reviewed; Region: rplX; PRK00004
195102007639	KOW motif of Ribosomal Protein L26; Region: KOW_RPL26; cd06089
195102007640	RNA binding site [nucleotide binding]; other site
195102007641	50S ribosomal protein L14; Validated; Region: rplN; PRK05483
195102007642	30S ribosomal protein S17; Reviewed; Region: rpsQ; PRK05610
195102007643	Ribosomal L29 protein/HIP.  L29 is a protein of the large ribosomal Subunit. A homolog, called heparin/heparan sulfate interacting protein (HIP), has also been identified in mammals.  L29 is located on the surface of the large ribosomal subunit, where it...; Region: Ribosomal_L29_HIP; cd00427
195102007644	23S rRNA interface [nucleotide binding]; other site
195102007645	putative translocon interaction site; other site
195102007646	signal recognition particle (SRP54) interaction site; other site
195102007647	L23 interface [polypeptide binding]; other site
195102007648	trigger factor interaction site; other site
195102007649	Ribosomal_L16_L10e: L16 is an essential protein in the large ribosomal subunit of bacteria, mitochondria, and chloroplasts. Large subunits that lack L16 are defective in peptidyl transferase activity, peptidyl-tRNA hydrolysis activity, association with...; Region: Ribosomal_L16_L10e; cd01433
195102007650	23S rRNA interface [nucleotide binding]; other site
195102007651	5S rRNA interface [nucleotide binding]; other site
195102007652	putative antibiotic binding site [chemical binding]; other site
195102007653	L25 interface [polypeptide binding]; other site
195102007654	L27 interface [polypeptide binding]; other site
195102007655	30S ribosomal protein S3; Reviewed; Region: rpsC; PRK00310
195102007656	K homology RNA-binding (KH) domain of the prokaryotic 30S small ribosomal subunit protein S3. S3  is part of the head region of the 30S ribosomal subunit and is believed to interact with mRNA as it threads its way from the latch into the channel.  The KH...; Region: 30S_S3_KH; cd02412
195102007657	G-X-X-G motif; other site
195102007658	Ribosomal protein S3, C-terminal domain; Region: Ribosomal_S3_C; pfam00189
195102007659	Ribosomal protein L22/L17e.  L22 (L17 in eukaryotes) is a core protein of the large ribosomal subunit.  It is the only ribosomal protein that interacts with all six domains of 23S rRNA, and is one of the proteins important for directing the proper...; Region: Ribosomal_L22; cd00336
195102007660	putative translocon binding site; other site
195102007661	protein-rRNA interface [nucleotide binding]; other site
195102007662	30S ribosomal protein S19; Reviewed; Region: rpsS; PRK00357
195102007663	50S ribosomal protein L2; Validated; Region: rplB; PRK09374
195102007664	Ribosomal Proteins L2, RNA binding domain; Region: Ribosomal_L2; pfam00181
195102007665	Ribosomal Proteins L2, C-terminal domain; Region: Ribosomal_L2_C; pfam03947
195102007666	50S ribosomal protein L23; Reviewed; Region: rplW; PRK05738
195102007667	50S ribosomal protein L4; Provisional; Region: rplD; PRK05319
195102007668	50S ribosomal protein L3; Validated; Region: rplC; PRK00001
195102007669	30S ribosomal protein S10; Reviewed; Region: rpsJ; PRK00596
195102007670	elongation factor Tu; Reviewed; Region: PRK00049
195102007671	Elongation Factor Tu (EF-Tu) GTP-binding proteins; Region: EF_Tu; cd01884
195102007672	G1 box; other site
195102007673	GEF interaction site [polypeptide binding]; other site
195102007674	GTP/Mg2+ binding site [chemical binding]; other site
195102007675	Switch I region; other site
195102007676	G2 box; other site
195102007677	G3 box; other site
195102007678	Switch II region; other site
195102007679	G4 box; other site
195102007680	G5 box; other site
195102007681	EFTU_II: Elongation factor Tu domain II. Elongation factors Tu (EF-Tu) are three-domain GTPases with an essential function in the elongation phase of mRNA translation. The GTPase center of EF-Tu is in the N-terminal domain (domain I), also known as the...; Region: EFTU_II; cd03697
195102007682	Domain III of elongation factor (EF) Tu. Ef-Tu consists of three structural domains, designated I, II and III. Domain III adopts a beta barrel structure. Domain III is involved in binding to both charged tRNA and binding to elongation factor Ts (EF-Ts); Region: EFTU_III; cd03707
195102007683	Antibiotic Binding Site [chemical binding]; other site
195102007684	elongation factor G; Reviewed; Region: PRK00007
195102007685	Elongation factor G (EF-G) family involved in both the elongation and ribosome recycling phases of protein synthesis; Region: EF-G; cd01886
195102007686	G1 box; other site
195102007687	putative GEF interaction site [polypeptide binding]; other site
195102007688	GTP/Mg2+ binding site [chemical binding]; other site
195102007689	Switch I region; other site
195102007690	G2 box; other site
195102007691	G3 box; other site
195102007692	Switch II region; other site
195102007693	G4 box; other site
195102007694	G5 box; other site
195102007695	EFG_mtEFG_II: this subfamily represents the domain II of elongation factor G (EF-G) in bacteria and, the C-terminus of mitochondrial Elongation factor G1 (mtEFG1) and G2 (mtEFG2)_like proteins found in eukaryotes. During the process of peptide synthesis...; Region: EFG_mtEFG_II; cd04088
195102007696	EFG_mtEFG1_IV: domains similar to domain IV of the bacterial translational elongation factor (EF) EF-G. Included in this group is a domain of mitochondrial Elongation factor G1 (mtEFG1) proteins homologous to domain IV of EF-G. Eukaryotic cells harbor 2...; Region: EFG_mtEFG1_IV; cd01434
195102007697	EFG_mtEFG_C: domains similar to the C-terminal domain of the bacterial translational elongation factor (EF) EF-G.  Included in this group is the C-terminus of mitochondrial Elongation factor G1 (mtEFG1) and G2 (mtEFG2) proteins. Eukaryotic cells harbor 2...; Region: EFG_mtEFG_C; cd03713
195102007698	30S ribosomal protein S7; Validated; Region: PRK05302
195102007699	S12-like family, 30S ribosomal protein S12 subfamily; S12 is located at the interface of the large and small ribosomal subunits of prokaryotes, chloroplasts and mitochondria, where it plays an important role in both tRNA and ribosomal subunit...; Region: Ribosomal_S12; cd03368
195102007700	S17 interaction site [polypeptide binding]; other site
195102007701	S8 interaction site; other site
195102007702	16S rRNA interaction site [nucleotide binding]; other site
195102007703	streptomycin interaction site [chemical binding]; other site
195102007704	23S rRNA interaction site [nucleotide binding]; other site
195102007705	aminoacyl-tRNA interaction site (A-site) [nucleotide binding]; other site
195102007706	Ribosomal protein L7Ae/L30e/S12e/Gadd45 family; Region: Ribosomal_L7Ae; cl00600
195102007707	DNA-directed RNA polymerase subunit beta'; Provisional; Region: PRK00566
195102007708	RNA polymerase Rpb1, domain 1; Region: RNA_pol_Rpb1_1; pfam04997
195102007709	RNA polymerase I subunit A N-terminus; Region: RPOLA_N; smart00663
195102007710	RNA polymerase Rpb1, domain 3; Region: RNA_pol_Rpb1_3; pfam04983
195102007711	RNA polymerase Rpb1, domain 4; Region: RNA_pol_Rpb1_4; pfam05000
195102007712	Largest subunit (beta') of Bacterial DNA-dependent RNA polymerase (RNAP), C-terminal domain; Region: RNAP_beta'_C; cd02655
195102007713	Rpb1 (beta') - Rpb6 (omega) interaction site [polypeptide binding]; other site
195102007714	G-loop; other site
195102007715	Largest subunit (beta') of Bacterial DNA-dependent RNA polymerase (RNAP), C-terminal domain; Region: RNAP_beta'_C; cd02655
195102007716	DNA binding site [nucleotide binding]
195102007717	Rpb1 (beta') - Rpb2 (beta) interaction site [polypeptide binding]; other site
195102007718	DNA-directed RNA polymerase subunit beta; Reviewed; Region: rpoB; PRK00405
195102007719	RNA polymerase beta subunit. RNA polymerases catalyse the DNA dependent polymerization of RNA. Prokaryotes contain a single RNA polymerase compared to three in eukaryotes (not including mitochondrial. and chloroplast polymerases). Each RNA polymerase...; Region: RNA_pol_B_RPB2; cl17585
195102007720	RNA polymerase Rpb2, domain 2; Region: RNA_pol_Rpb2_2; pfam04561
195102007721	RNA polymerase beta subunit. RNA polymerases catalyse the DNA dependent polymerization of RNA. Prokaryotes contain a single RNA polymerase compared to three in eukaryotes (not including mitochondrial. and chloroplast polymerases). Each RNA polymerase...; Region: RNA_pol_B_RPB2; cd00653
195102007722	RPB1 interaction site [polypeptide binding]; other site
195102007723	RPB10 interaction site [polypeptide binding]; other site
195102007724	RPB11 interaction site [polypeptide binding]; other site
195102007725	RPB3 interaction site [polypeptide binding]; other site
195102007726	RPB12 interaction site [polypeptide binding]; other site
195102007727	Ribosomal protein L7/L12. Ribosomal protein L7/L12 refers to the large ribosomal subunit proteins L7 and L12, which are identical except that L7 is acetylated at the N terminus. It is a component of the L7/L12 stalk, which is located at the surface of...; Region: Ribosomal_L7_L12; cd00387
195102007728	core dimer interface [polypeptide binding]; other site
195102007729	peripheral dimer interface [polypeptide binding]; other site
195102007730	L10 interface [polypeptide binding]; other site
195102007731	L11 interface [polypeptide binding]; other site
195102007732	putative EF-Tu interaction site [polypeptide binding]; other site
195102007733	putative EF-G interaction site [polypeptide binding]; other site
195102007734	Ribosomal protein L10 family, L10 subfamily; composed of bacterial 50S ribosomal protein and eukaryotic mitochondrial 39S ribosomal protein, L10. L10 occupies the L7/L12 stalk of the ribosome. The N-terminal domain (NTD) of L10 interacts with L11 protein...; Region: Ribosomal_L10; cd05797
195102007735	23S rRNA interface [nucleotide binding]; other site
195102007736	Interface with L7/L12 ribosomal proteins [polypeptide binding]; other site
195102007737	Ribosomal protein L1.  The L1 protein, located near the E-site of the ribosome, forms part of the L1 stalk along with 23S rRNA.  In bacteria and archaea, L1 functions both as a ribosomal protein that binds rRNA, and as a translation repressor that binds...; Region: Ribosomal_L1; cd00403
195102007738	mRNA/rRNA interface [nucleotide binding]; other site
195102007739	50S ribosomal protein L11; Validated; Region: rplK; PRK00140
195102007740	Ribosomal protein L11. Ribosomal protein L11, together with proteins L10 and L7/L12, and 23S rRNA, form the L7/L12 stalk on the surface of the large subunit of the ribosome. The homologous eukaryotic cytoplasmic protein is also called 60S ribosomal...; Region: Ribosomal_L11; cd00349
195102007741	23S rRNA interface [nucleotide binding]; other site
195102007742	L7/L12 interface [polypeptide binding]; other site
195102007743	putative thiostrepton binding site; other site
195102007744	L25 interface [polypeptide binding]; other site
195102007745	transcription antitermination protein NusG; Validated; Region: nusG; PRK05609
195102007746	Bacterial N-Utilization Substance G (NusG) N-terminal (NGN) domain, subgroup 1; Region: NGN_Bact_1; cd09891
195102007747	putative homodimer interface [polypeptide binding]; other site
195102007748	NusG contains an NGN domain at its N-terminus and KOW motif at its C-terminus; Region: KOW_NusG; cd06091
195102007749	heterodimer interface [polypeptide binding]; other site
195102007750	homodimer interface [polypeptide binding]; other site
195102007751	preprotein translocase, SecE subunit, bacterial; Region: secE_bact; TIGR00964
195102007752	50S ribosomal protein L33; Validated; Region: rpmG; PRK00504
195102007753	elongation factor Tu; Reviewed; Region: PRK00049
195102007754	Elongation Factor Tu (EF-Tu) GTP-binding proteins; Region: EF_Tu; cd01884
195102007755	G1 box; other site
195102007756	GEF interaction site [polypeptide binding]; other site
195102007757	GTP/Mg2+ binding site [chemical binding]; other site
195102007758	Switch I region; other site
195102007759	G2 box; other site
195102007760	G3 box; other site
195102007761	Switch II region; other site
195102007762	G4 box; other site
195102007763	G5 box; other site
195102007764	EFTU_II: Elongation factor Tu domain II. Elongation factors Tu (EF-Tu) are three-domain GTPases with an essential function in the elongation phase of mRNA translation. The GTPase center of EF-Tu is in the N-terminal domain (domain I), also known as the...; Region: EFTU_II; cd03697
195102007765	Domain III of elongation factor (EF) Tu. Ef-Tu consists of three structural domains, designated I, II and III. Domain III adopts a beta barrel structure. Domain III is involved in binding to both charged tRNA and binding to elongation factor Ts (EF-Ts); Region: EFTU_III; cd03707
195102007766	Antibiotic Binding Site [chemical binding]; other site
195102007767	RNA polymerase sigma-H factor; Region: spore_sigH; TIGR02859
195102007768	Sigma-70 region 2; Region: Sigma70_r2; pfam04542
195102007769	Sigma-70, region 4; Region: Sigma70_r4_2; pfam08281
195102007770	YacP-like NYN domain; Region: NYN_YacP; pfam05991
195102007771	rRNA methylases [Translation, ribosomal structure and biogenesis]; Region: SpoU; COG0566
195102007772	RNA 2'-O ribose methyltransferase substrate binding; Region: SpoU_sub_bind; pfam08032
195102007773	SpoU rRNA Methylase family; Region: SpoU_methylase; pfam00588
195102007774	FAD-dependent thymidylate synthase; Reviewed; Region: thyX; PRK00847
195102007775	Ribonuclease III family protein [Replication, recombination, and    repair]; Region: COG1939
195102007776	dimerization interface [polypeptide binding]; other site
195102007777	active site
195102007778	metal binding site [ion binding]; metal-binding site
195102007779	cysteinyl-tRNA synthetase; Validated; Region: cysS; PRK00260
195102007780	catalytic core domain of cysteinyl tRNA synthetase; Region: CysRS_core; cd00672
195102007781	active site
195102007782	HIGH motif; other site
195102007783	catalytic core domain of cysteinyl tRNA synthetase; Region: CysRS_core; cd00672
195102007784	KMSKS motif; other site
195102007785	Anticodon-binding domain of cysteinyl tRNA synthetases; Region: Anticodon_Ia_Cys; cd07963
195102007786	tRNA binding surface [nucleotide binding]; other site
195102007787	anticodon binding site; other site
195102007788	prolyl-tRNA synthetase; Provisional; Region: PRK09194
195102007789	Prolyl-tRNA synthetase (ProRS) class II core catalytic domain. ProRS is a homodimer. It is responsible for the attachment of proline to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for ATP-dependent...; Region: ProRS_core_prok; cd00779
195102007790	dimer interface [polypeptide binding]; other site
195102007791	motif 1; other site
195102007792	active site
195102007793	motif 2; other site
195102007794	INS is an amino acid-editing domain inserted (INS) into the bacterial class II prolyl-tRNA synthetase (ProRS) however, this CD is not exclusively bacterial. It is also found at the N-terminus of the eukaryotic/archaea-like ProRS's of yeasts and...; Region: ProRS-INS; cd04334
195102007795	putative deacylase active site [active]
195102007796	Class II tRNA amino-acyl synthetase-like catalytic core domain. Class II amino acyl-tRNA synthetases (aaRS) share a common fold and generally attach an amino acid to the 3' OH of ribose of the appropriate tRNA.   PheRS is an exception in that it...; Region: class_II_aaRS-like_core; cl00268
195102007797	active site
195102007798	motif 3; other site
195102007799	ProRS Prolyl-anticodon binding domain, short version found predominantly in bacteria. ProRS belongs to class II aminoacyl-tRNA synthetases (aaRS). This alignment contains the anticodon binding domain, which is responsible for specificity in tRNA-binding; Region: ProRS_anticodon_short; cd00861
195102007800	anticodon binding site; other site
195102007801	CDP-ME synthetase is involved in mevalonate-independent isoprenoid production; Region: CDP-ME_synthetase; cd02516
195102007802	substrate binding site; other site
195102007803	dimer interface; other site
195102007804	Integral membrane protein (PIN domain superfamily) [General function prediction only]; Region: COG4956
195102007805	PIN domain of Thermus Thermophilus Hb8, uncharacterized Bacillus subtilis YacL, and other bacterial homologs; Region: PIN_YacL; cd09877
195102007806	putative active site [active]
195102007807	Nucleoside Triphosphate Pyrophosphohydrolase (EC 3.6.1.8) MazG-like domain superfamily; Region: NTP-PPase; cl16941
195102007808	DNA integrity scanning protein DisA; Provisional; Region: PRK13482
195102007809	DisA bacterial checkpoint controller nucleotide-binding; Region: DisA_N; pfam02457
195102007810	DisA bacterial checkpoint controller linker region; Region: DisA-linker; pfam10635
195102007811	DNA repair protein RadA; Provisional; Region: PRK11823
195102007812	Sms (bacterial radA) DNA repair protein. This protein is not related to archael radA any more than is to other RecA-like NTPases. Sms has a role in recombination and recombinational repair and is responsible for the stabilization or processing of...; Region: Sms; cd01121
195102007813	Walker A motif/ATP binding site; other site
195102007814	ATP binding site [chemical binding]; other site
195102007815	Walker B motif; other site
195102007816	6-phosphogluconolactonase/Glucosamine-6-phosphate isomerase/deaminase [Carbohydrate transport and metabolism]; Region: NagB; COG0363
195102007817	GlcN6P_deaminase: Glucosamine-6-phosphate (GlcN6P) deaminase subfamily; GlcN6P deaminase catalyzes the reversible conversion of GlcN6P to D-fructose-6-phosphate (Fru6P) and ammonium. The reaction is an aldo-keto isomerization coupled with an amination or...; Region: GlcN6P_deaminase; cd01399
195102007818	active site
195102007819	trimer interface [polypeptide binding]; other site
195102007820	allosteric site; other site
195102007821	active site lid [active]
195102007822	hexamer (dimer of trimers) interface [polypeptide binding]; other site
195102007823	Transcriptional regulators [Transcription]; Region: PhnF; COG2188
195102007824	Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377
195102007825	DNA-binding site [nucleotide binding]; DNA binding site
195102007826	UTRA domain; Region: UTRA; pfam07702
195102007827	NrdH-redoxin (NrdH) family; NrdH is a small monomeric protein with a conserved redox active CXXC motif within a TRX fold, characterized by a glutaredoxin (GRX)-like sequence and TRX-like activity profile. In vitro, it displays protein disulfide reductase...; Region: NrdH; cd02976
195102007828	catalytic residues [active]
195102007829	NADP+-dependent non-phosphorylating glyceraldehyde 3-phosphate dehydrogenase and ALDH family 11; Region: ALDH_F11_NP-GAPDH; cd07082
195102007830	Aldehyde dehydrogenase family; Region: Aldedh; pfam00171
195102007831	tetrameric interface [polypeptide binding]; other site
195102007832	activator binding site; other site
195102007833	NADP binding site [chemical binding]; other site
195102007834	substrate binding site [chemical binding]; other site
195102007835	catalytic residues [active]
195102007836	NrdH-redoxin (NrdH) family; NrdH is a small monomeric protein with a conserved redox active CXXC motif within a TRX fold, characterized by a glutaredoxin (GRX)-like sequence and TRX-like activity profile. In vitro, it displays protein disulfide reductase...; Region: NrdH; cd02976
195102007837	catalytic residues [active]
195102007838	thioredoxin-disulfide reductase; Region: TRX_reduct; TIGR01292
195102007839	NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500
195102007840	ATP-binding subunits of Clp protease and DnaK/DnaJ chaperones [Posttranslational modification, protein turnover, chaperones]; Region: clpA; COG0542
195102007841	Clp amino terminal domain; Region: Clp_N; pfam02861
195102007842	Clp amino terminal domain; Region: Clp_N; pfam02861
195102007843	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
195102007844	Walker A motif; other site
195102007845	ATP binding site [chemical binding]; other site
195102007846	Walker B motif; other site
195102007847	arginine finger; other site
195102007848	UvrB/uvrC motif; Region: UVR; pfam02151
195102007849	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
195102007850	Walker A motif; other site
195102007851	ATP binding site [chemical binding]; other site
195102007852	Walker B motif; other site
195102007853	C-terminal, D2-small domain, of ClpB protein; Region: ClpB_D2-small; pfam10431
195102007854	ATP:guanido phosphotransferase; Provisional; Region: PRK01059
195102007855	Phosphagen (guanidino) kinases found in bacteria; Region: bacterial_phosphagen_kinase; cd07930
195102007856	ADP binding site [chemical binding]; other site
195102007857	phosphagen binding site; other site
195102007858	substrate specificity loop; other site
195102007859	Modulator of heat shock repressor CtsR, McsA [Signal transduction    mechanisms]; Region: COG3880
195102007860	Firmicute transcriptional repressor of class III stress genes (CtsR); Region: CtsR; pfam05848
195102007861	Predicted Zn-dependent hydrolases of the beta-lactamase fold [General function prediction only]; Region: COG2220
195102007862	Beta-lactamase superfamily domain; Region: Lactamase_B_3; pfam13483
195102007863	Mur ligase middle domain; Region: Mur_ligase_M; pfam08245
195102007864	Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875
195102007865	The HCP family of iron-sulfur proteins includes hybrid cluster protein (HCP), acetyl-CoA synthase (ACS), and carbon monoxide dehydrogenase (CODH), all of which contain [Fe4-S4] metal clusters at their active sites. These proteins have a conserved...; Region: HCP_like; cl14655
195102007866	4Fe-4S dicluster domain; Region: Fer4_7; pfam12838
195102007867	Uncharacterized homolog of PSP1 [Function unknown]; Region: COG1774
195102007868	DNA polymerase III subunit delta'; Validated; Region: PRK05564
195102007869	DNA polymerase III subunit delta'; Validated; Region: PRK08485
195102007870	Protein of unknown function (DUF970); Region: DUF970; pfam06153
195102007871	Guanosine monophosphate kinase (GMPK, EC 2.7.4.8), also known as guanylate kinase (GKase), catalyzes the reversible phosphoryl transfer from adenosine triphosphate (ATP) to guanosine monophosphate (GMP) to yield adenosine diphosphate (ADP) and guanosine...; Region: GMPK; cd00071
195102007872	AAA domain; Region: AAA_18; pfam13238
195102007873	catalytic site [active]
195102007874	G-X2-G-X-G-K; other site
195102007875	Arginine/lysine/ornithine decarboxylases [Amino acid transport and metabolism]; Region: LdcC; COG1982
195102007876	Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321
195102007877	pyridoxal 5'-phosphate binding pocket [chemical binding]; other site
195102007878	catalytic residue [active]
195102007879	Orn/Lys/Arg decarboxylase, C-terminal domain; Region: OKR_DC_1_C; pfam03711
195102007880	Inhibitor of sigma-G Gin; Region: Gin; pfam10764
195102007881	Zinc peptidases M18, M20, M28, and M42; Region: Zinc_peptidase_like; cl14876
195102007882	amidohydrolase; Region: amidohydrolases; TIGR01891
195102007883	metal binding site [ion binding]; metal-binding site
195102007884	Mg2+ and Co2+ transporters [Inorganic ion transport and metabolism]; Region: CorA; COG0598
195102007885	uncharacterized bacterial subfamily of the Escherichia coli CorA-Salmonella typhimurium ZntB family; Region: EcCorA_ZntB-like_u2; cd12827
195102007886	Cl binding site [ion binding]; other site
195102007887	oligomer interface [polypeptide binding]; other site
195102007888	LD-Carboxypeptidase, a serine protease, includes microcin C7 self immunity protein; Region: Peptidase_S66; cd07025
195102007889	dimer interface [polypeptide binding]; other site
195102007890	catalytic triad [active]
195102007891	UDP-N-acetylmuramoyl-L-alanyl-D-glutamate synthetase; Provisional; Region: murD; PRK01710
195102007892	Mur ligase middle domain; Region: Mur_ligase_M; pfam08245
195102007893	Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875
195102007894	biotin synthase; Provisional; Region: PRK07094
195102007895	Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335
195102007896	FeS/SAM binding site; other site
195102007897	Biotin and Thiamin Synthesis associated domain; Region: BATS; pfam06968
195102007898	dihydropyrimidine dehydrogenase subunit A; Provisional; Region: PRK11749
195102007899	NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500
195102007900	Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070
195102007901	Microcin C7 self-immunity protein determines resistance to exogenous microcin C7; Region: Peptidase_S66_mccF_like; cd07062
195102007902	putative dimer interface [polypeptide binding]; other site
195102007903	catalytic triad [active]
195102007904	M20 Peptidase T like enzymes specifically cleave tripeptides; Region: M20_peptT_like; cd05683
195102007905	peptidase T-like protein; Region: PepT-like; TIGR01883
195102007906	metal binding site [ion binding]; metal-binding site
195102007907	putative dimer interface [polypeptide binding]; other site
195102007908	glycyl-tRNA synthetase; Provisional; Region: PRK04173
195102007909	Class II tRNA amino-acyl synthetase-like catalytic core domain. Class II amino acyl-tRNA synthetases (aaRS) share a common fold and generally attach an amino acid to the 3' OH of ribose of the appropriate tRNA.   PheRS is an exception in that it...; Region: class_II_aaRS-like_core; cl00268
195102007910	motif 1; other site
195102007911	Glycyl-tRNA synthetase (GlyRS)-like class II core catalytic domain. GlyRS functions as a homodimer in eukaryotes, archaea and some bacteria and as a heterotetramer in the remainder of prokaryotes. It is responsible for the attachment of glycine to the 3...; Region: GlyRS-like_core; cd00774
195102007912	active site
195102007913	motif 2; other site
195102007914	motif 3; other site
195102007915	GlyRS Glycyl-anticodon binding domain. GlyRS belongs to class II aminoacyl-tRNA synthetases (aaRS). This alignment contains the anticodon binding domain, which is responsible for specificity in tRNA-binding, so that the activated amino acid is...; Region: GlyRS_anticodon; cd00858
195102007916	anticodon binding site; other site
195102007917	lysyl-tRNA synthetase; Reviewed; Region: lysS; PRK00484
195102007918	LysRS_N: N-terminal, anticodon recognition domain of lysyl-tRNA synthetases (LysRS). These enzymes are homodimeric class 2b aminoacyl-tRNA synthetases (aaRSs). This domain is a beta-barrel domain (OB fold) involved in binding the tRNA anticodon stem-loop; Region: LysRS_N; cd04322
195102007919	dimer interface [polypeptide binding]; other site
195102007920	putative anticodon binding site; other site
195102007921	Lys_tRNA synthetase (LysRS) class II core domain. Class II LysRS is a dimer which attaches a lysine to the 3' OH group of ribose of the appropriate tRNA. Its assignment to class II aaRS is based upon its structure and the presence of three...; Region: LysRS_core; cd00775
195102007922	motif 1; other site
195102007923	active site
195102007924	motif 2; other site
195102007925	motif 3; other site
195102007926	transcription elongation factor GreA; Reviewed; Region: greA; PRK00226
195102007927	Transcription elongation factor, N-terminal; Region: GreA_GreB_N; pfam03449
195102007928	Transcription elongation factor, GreA/GreB, C-term; Region: GreA_GreB; pfam01272
195102007929	putative TIM-barrel protein, nifR3 family; Region: nifR3_yhdG; TIGR00737
195102007930	Dihydrouridine synthase-like (DUS-like) FMN-binding domain. Members of this family catalyze the reduction of the 5,6-double bond of a uridine residue on tRNA. Dihydrouridine modification of tRNA is widely observed in prokaryotes and eukaryotes, and also...; Region: DUS_like_FMN; cd02801
195102007931	FMN binding site [chemical binding]; other site
195102007932	active site
195102007933	catalytic residues [active]
195102007934	substrate binding site [chemical binding]; other site
195102007935	Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cd00012
195102007936	nucleotide binding site [chemical binding]; other site
195102007937	Type III pantothenate kinase; Region: Pan_kinase; cl17198
195102007938	formate--tetrahydrofolate ligase; Provisional; Region: PRK13505
195102007939	Formyltetrahydrofolate synthetase (FTHFS) catalyzes the ATP-dependent activation of formate ion via its addition to the N10 position of tetrahydrofolate. FTHFS is a highly expressed key enzyme in both the Wood-Ljungdahl pathway of autotrophic CO2...; Region: FTHFS; cd00477
195102007940	Potassium binding sites [ion binding]; other site
195102007941	Cesium cation binding sites [ion binding]; other site
195102007942	FtsH Extracellular; Region: FtsH_ext; pfam06480
195102007943	ATP-dependent metalloprotease FtsH; Region: FtsH_fam; TIGR01241
195102007944	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
195102007945	Walker A motif; other site
195102007946	ATP binding site [chemical binding]; other site
195102007947	Walker B motif; other site
195102007948	arginine finger; other site
195102007949	Peptidase family M41; Region: Peptidase_M41; pfam01434
195102007950	Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223
195102007951	active site
195102007952	tRNA(Ile)-lysidine synthase MesJ [Cell cycle control, cell division, chromosome partitioning]; Region: MesJ; COG0037
195102007953	N-terminal domain of predicted ATPase of the PP-loop faimly implicated in cell cycle control [Cell division and chromosome partitioning]. This is a subfamily of Adenine nucleotide alpha hydrolases superfamily.Adeninosine nucleotide alpha hydrolases...; Region: PP-ATPase; cd01992
195102007954	Ligand Binding Site [chemical binding]; other site
195102007955	TilS substrate C-terminal domain; Region: TilS_C; smart00977
195102007956	stage II sporulation protein E; Region: spore_II_E; TIGR02865
195102007957	Stage II sporulation protein E (SpoIIE); Region: SpoIIE; pfam07228
195102007958	hypothetical protein; Provisional; Region: PRK05807
195102007959	S1_like: Ribosomal protein S1-like RNA-binding domain. Found in a wide variety of RNA-associated proteins. Originally identified in S1 ribosomal protein. This superfamily also contains the Cold Shock Domain (CSD), which is a homolog of the S1 domain; Region: S1_like; cl09927
195102007960	RNA binding site [nucleotide binding]; other site
195102007961	Septum formation initiator; Region: DivIC; pfam04977
195102007962	Septum formation initiator [Cell division and chromosome partitioning]; Region: COG2919
195102007963	spore cortex biosynthesis protein YabQ; Region: spore_yabQ; TIGR02893
195102007964	sporulation protein YabP; Region: spore_yabP; TIGR02892
195102007965	S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site;  Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165
195102007966	RNA binding surface [nucleotide binding]; other site
195102007967	Integration host factor (IHF) and HU are small heterodimeric members of the DNABII protein family that bind and bend DNA, functioning as architectural factors in many cellular processes including transcription, site-specific recombination, and...; Region: HU_IHF; cd00591
195102007968	IHF dimer interface [polypeptide binding]; other site
195102007969	IHF - DNA interface [nucleotide binding]; other site
195102007970	Protein containing tetrapyrrole methyltransferase domain and MazG-like (predicted pyrophosphatase) domain [General function prediction only]; Region: COG3956
195102007971	N-terminal S-AdoMet dependent methylase domain of Bacillus subtilis YabN and related proteins; Region: YabN_N; cd11723
195102007972	putative SAM binding site [chemical binding]; other site
195102007973	putative homodimer interface [polypeptide binding]; other site
195102007974	Nucleoside Triphosphate Pyrophosphohydrolase (EC 3.6.1.8) N-terminal tandem-domain of MazG proteins from Escherichia coli and bacterial homologs; Region: NTP-PPase_MazG_Nterm; cd11528
195102007975	homodimer interface [polypeptide binding]; other site
195102007976	metal binding site [ion binding]; metal-binding site
195102007977	Nucleoside Triphosphate Pyrophosphohydrolase (EC 3.6.1.8) C-terminal tandem-domain of MazG proteins from Escherichia coli and bacterial homologs' Region: NTP-PPase_MazG_Cterm; cd11529
195102007978	homodimer interface [polypeptide binding]; other site
195102007979	active site
195102007980	putative chemical substrate binding site [chemical binding]; other site
195102007981	metal binding site [ion binding]; metal-binding site
195102007982	stage V sporulation protein B; Region: spore_V_B; TIGR02900
195102007983	Stage V sporulation protein B, also known as Stage III sporulation protein F, and related proteins; Region: MATE_SpoVB_like; cd13124
195102007984	stage V sporulation protein T; Region: spore_V_T; TIGR02851
195102007985	looped-hinge helix DNA binding domain, AbrB family; Region: lp_hng_hel_AbrB; TIGR01439
195102007986	peptidylprolyl isomerase; Provisional; Region: prsA; PRK00059
195102007987	SurA N-terminal domain; Region: SurA_N_3; cl07813
195102007988	PPIC-type PPIASE domain; Region: Rotamase; pfam00639
195102007989	Transcription-repair coupling factor (superfamily II helicase) [DNA replication, recombination, and repair / Transcription]; Region: Mfd; COG1197
195102007990	CarD-like/TRCF domain; Region: CarD_TRCF; smart01058
195102007991	DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046
195102007992	ATP binding site [chemical binding]; other site
195102007993	putative Mg++ binding site [ion binding]; other site
195102007994	Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079
195102007995	nucleotide binding region [chemical binding]; other site
195102007996	ATP-binding site [chemical binding]; other site
195102007997	This domain is found in proteins necessary for strand-specific repair in DNA such as TRCF in Escherichia coli; Region: TRCF; smart00982
195102007998	Peptidyl-tRNA hydrolase (PTH) is a monomeric protein that cleaves the ester bond linking the nascent peptide and tRNA when peptidyl-tRNA is released prematurely from the ribosome. This ensures the recycling of peptidyl-tRNAs into tRNAs produced through...; Region: PTH; cd00462
195102007999	putative active site [active]
195102008000	catalytic residue [active]
195102008001	Trypsin-like peptidase domain; Region: Trypsin_2; pfam13365
195102008002	PDZ domain of tryspin-like serine proteases, such as DegP/HtrA, which are oligomeric proteins involved in heat-shock response, chaperone function, and apoptosis. May be responsible for substrate recognition and/or binding, as most PDZ domains bind...; Region: PDZ_serine_protease; cd00987
195102008003	protein binding site [polypeptide binding]; other site
195102008004	Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642
195102008005	Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225
195102008006	dimerization interface [polypeptide binding]; other site
195102008007	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
195102008008	dimer interface [polypeptide binding]; other site
195102008009	phosphorylation site [posttranslational modification]
195102008010	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
195102008011	ATP binding site [chemical binding]; other site
195102008012	Mg2+ binding site [ion binding]; other site
195102008013	G-X-G motif; other site
195102008014	Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745
195102008015	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
195102008016	active site
195102008017	phosphorylation site [posttranslational modification]
195102008018	intermolecular recognition site; other site
195102008019	dimerization interface [polypeptide binding]; other site
195102008020	Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383
195102008021	DNA binding site [nucleotide binding]
195102008022	ribose-phosphate pyrophosphokinase; Provisional; Region: PRK01259
195102008023	N-terminal domain of ribose phosphate pyrophosphokinase; Region: Pribosyltran_N; pfam13793
195102008024	Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223
195102008025	active site
195102008026	bifunctional N-acetylglucosamine-1-phosphate uridyltransferase/glucosamine-1-phosphate acetyltransferase; Provisional; Region: glmU; PRK14354
195102008027	N-terminal domain of bacterial GlmU; Region: GT2_GlmU_N_bac; cd02540
195102008028	Substrate binding site; other site
195102008029	Mg++ binding site; other site
195102008030	N-acetyl-glucosamine-1-phosphate uridyltransferase (GlmU), C-terminal left-handed beta-helix (LbH) acetyltransferase domain: GlmU is also known as UDP-N-acetylglucosamine pyrophosphorylase. It is a bifunctional bacterial enzyme that catalyzes two...; Region: LbH_GlmU_C; cd03353
195102008031	active site
195102008032	substrate binding site [chemical binding]; other site
195102008033	CoA binding site [chemical binding]; other site
195102008034	regulatory protein SpoVG; Reviewed; Region: PRK13259
195102008035	pur operon repressor, Bacillus subtilis type; Region: purR_Bsub; TIGR01743
195102008036	Bacterial purine repressor, N-terminal; Region: PuR_N; pfam09182
195102008037	Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223
195102008038	active site
195102008039	UDP-N-acetylmuramate--L-alanine ligase; Provisional; Region: murC; PRK00421
195102008040	Mur ligase family, catalytic domain; Region: Mur_ligase; pfam01225
195102008041	Mur ligase middle domain; Region: Mur_ligase_M; pfam08245
195102008042	Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875
195102008043	Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cl17402
195102008044	DNA-binding transcriptional regulator CytR; Provisional; Region: PRK11041
195102008045	Ligand binding domain of the LacI tanscriptional regulator family belonging to the type I periplasmic-binding fold protein superfamily; Region: PBP1_LacI_sugar_binding_like; cd06267
195102008046	dimerization interface [polypeptide binding]; other site
195102008047	ligand binding site [chemical binding]; other site
195102008048	purine nucleoside phosphorylase; Provisional; Region: PRK08202
195102008049	Nucleoside permease [Nucleotide transport and metabolism]; Region: NupC; COG1972
195102008050	Na+ dependent nucleoside transporter N-terminus; Region: Nucleos_tra2_N; pfam01773
195102008051	Nucleoside recognition; Region: Gate; pfam07670
195102008052	Na+ dependent nucleoside transporter C-terminus; Region: Nucleos_tra2_C; pfam07662
195102008053	Xaa-Pro aminopeptidase [Amino acid transport and metabolism]; Region: PepP; COG0006
195102008054	Creatinase/Prolidase N-terminal domain; Region: Creatinase_N; pfam01321
195102008055	Similar to Prolidase and Aminopeptidase P. The members of this subfamily presumably catalyse hydrolysis of Xaa-Pro dipeptides and/or release of any N-terminal amino acid, including proline, that is linked with proline; Region: APP-like; cd01092
195102008056	active site
195102008057	Escherichia coli YfcE and related proteins, metallophosphatase domain; Region: MPP_YfcE; cd00841
195102008058	Calcineurin-like phosphoesterase; Region: Metallophos; pfam00149
195102008059	active site
195102008060	metal binding site [ion binding]; metal-binding site
195102008061	homotetramer interface [polypeptide binding]; other site
195102008062	Cytochrome b5-like Heme/Steroid binding domain; Region: Cyt-b5; cl02041
195102008063	Cytochrome b5-like Heme/Steroid binding domain; Region: Cyt-b5; cl02041
195102008064	Cytochrome b5-like Heme/Steroid binding domain; Region: Cyt-b5; cl02041
195102008065	Cytochrome b5-like Heme/Steroid binding domain; Region: Cyt-b5; cl02041
195102008066	asparaginyl-tRNA synthetase; Validated; Region: asnC; PRK03932
195102008067	EcAsnRS_like_N: N-terminal, anticodon recognition domain of the type found in Escherichia coli asparaginyl-tRNA synthetase (AsnRS) and, in Arabidopsis thaliana and Saccharomyces cerevisiae mitochondrial (mt) AsnRS. This domain is a beta-barrel domain (OB...; Region: EcAsnRS_like_N; cd04318
195102008068	putative dimer interface [polypeptide binding]; other site
195102008069	putative anticodon binding site; other site
195102008070	Asx tRNA synthetase (AspRS/AsnRS) class II core domain.  Assignment to class II aminoacyl-tRNA synthetases (aaRS) based upon its structure and the presence of three characteristic sequence motifs in the core domain. This family includes AsnRS as well as...; Region: AsxRS_core; cd00776
195102008071	homodimer interface [polypeptide binding]; other site
195102008072	motif 1; other site
195102008073	motif 2; other site
195102008074	active site
195102008075	motif 3; other site
195102008076	Leucyl aminopeptidase [Amino acid transport and metabolism]; Region: PepB; COG0260
195102008077	Cytosol aminopeptidase family, N-terminal and catalytic domains.  Family M17 contains zinc- and manganese-dependent exopeptidases ( EC  3.4.11.1), including leucine aminopeptidase. They catalyze removal of amino acids from the N-terminus of a protein and...; Region: Peptidase_M17; cd00433
195102008078	interface (dimer of trimers) [polypeptide binding]; other site
195102008079	Substrate-binding/catalytic site; other site
195102008080	Zn-binding sites [ion binding]; other site
195102008081	YcxB-like protein; Region: YcxB; pfam14317
195102008082	anaerobic ribonucleoside-triphosphate reductase activating protein; Region: NrdG; TIGR02491
195102008083	Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335
195102008084	FeS/SAM binding site; other site
195102008085	Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077
195102008086	Zn2+ binding site [ion binding]; other site
195102008087	Mg2+ binding site [ion binding]; other site
195102008088	Na+-driven multidrug efflux pump [Defense mechanisms]; Region: NorM; COG0534
195102008089	Uncharacterized subfamily of the multidrug and toxic compound extrusion (MATE) proteins; Region: MATE_like_8; cd13134
195102008090	Adenosine deaminase [Nucleotide transport and metabolism]; Region: Add; COG1816
195102008091	Adenosine deaminase (ADA) is a monomeric zinc dependent enzyme which catalyzes the irreversible hydrolytic deamination of both adenosine, as well as desoxyadenosine, to ammonia and inosine or desoxyinosine, respectively. ADA plays an important role in...; Region: ADA; cd01320
195102008092	active site
195102008093	purine riboside binding site [chemical binding]; other site
195102008094	anaerobic ribonucleoside triphosphate reductase; Provisional; Region: PRK07111
195102008095	ATP cone domain; Region: ATP-cone; pfam03477
195102008096	Class III ribonucleotide reductase; Region: RNR_III; cd01675
195102008097	effector binding site; other site
195102008098	active site
195102008099	Zn binding site [ion binding]; other site
195102008100	glycine loop; other site
195102008101	Protein of unknown function (DUF3048); Region: DUF3048; pfam11258
195102008102	EDD domain protein, DegV family; Region: DegV; TIGR00762
195102008103	Uncharacterized protein, DegV family COG1307; Region: DegV; pfam02645
195102008104	Predicted transcriptional regulators [Transcription]; Region: COG1695
195102008105	Transcriptional regulator PadR-like family; Region: PadR; pfam03551
195102008106	4Fe-4S single cluster domain; Region: Fer4_15; pfam13459
195102008107	Protein of unknown function (DUF1271); Region: DUF1271; cl01443
195102008108	ATPases involved in chromosome partitioning [Cell division and chromosome partitioning]; Region: Mrp; COG0489
195102008109	MRP (Multiple Resistance and pH adaptation) is a homologue of the Fer4_NifH superfamily. Like the other members of the superfamily, MRP contains a ATP-binding domain at the N-termini. It is found in bacteria as a membrane-spanning protein and functions...; Region: MRP-like; cd02037
195102008110	prolipoprotein diacylglyceryl transferase; Reviewed; Region: PRK00052
195102008111	16S ribosomal RNA methyltransferase KsgA/Dim1 family protein; Reviewed; Region: ksgA; PRK00274
195102008112	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
195102008113	S-adenosylmethionine binding site [chemical binding]; other site
195102008114	ribonuclease M5; Region: 5S_RNA_mat_M5; TIGR00334
195102008115	TOPRIM_ RNase M5_like: The topoisomerase-primase (TOPRIM) nucleotidyl transferase/hydrolase domain found in Ribonuclease M5: (RNase M5) and other small primase-like proteins from bacteria and archaea.  RNase M5 catalyzes the maturation of 5S rRNA in low...; Region: TOPRIM_RNase_M5_like; cd01027
195102008116	putative active site [active]
195102008117	putative metal binding site [ion binding]; other site
195102008118	Domain of unknown function (DUF4093); Region: DUF4093; pfam13331
195102008119	Domain of unknown function (DUF348); Region: DUF348; pfam03990
195102008120	Domain of unknown function (DUF348); Region: DUF348; pfam03990
195102008121	G5 domain; Region: G5; pfam07501
195102008122	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3584
195102008123	TatD like proteins;  E.coli TatD is a cytoplasmic protein, shown to have magnesium dependent DNase activity; Region: TatD_DNAse; cd01310
195102008124	Predicted metal-dependent hydrolases with the TIM-barrel fold [General function prediction only]; Region: COG1099
195102008125	active site
195102008126	Protein of unknown function (DUF445); Region: DUF445; pfam04286
195102008127	cAMP-binding proteins - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases [Signal transduction mechanisms]; Region: Crp; COG0664
195102008128	effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038
195102008129	ligand binding site [chemical binding]; other site
195102008130	flexible hinge region; other site
195102008131	Crp-like helix-turn-helix domain; Region: HTH_Crp_2; pfam13545
195102008132	methionyl-tRNA synthetase; Reviewed; Region: PRK12268
195102008133	catalytic core domain of methioninyl-tRNA synthetases; Region: MetRS_core; cd00814
195102008134	active site
195102008135	HIGH motif; other site
195102008136	KMSKS motif; other site
195102008137	Anticodon-binding domain of methionyl tRNA synthetases; Region: Anticodon_Ia_Met; cd07957
195102008138	tRNA binding surface [nucleotide binding]; other site
195102008139	anticodon binding site; other site
195102008140	methionyl-tRNA synthetase; Reviewed; Region: PRK12267
195102008141	catalytic core domain of methioninyl-tRNA synthetases; Region: MetRS_core; cd00814
195102008142	HIGH motif; other site
195102008143	active site
195102008144	KMSKS motif; other site
195102008145	Anticodon-binding domain of methionyl tRNA synthetases; Region: Anticodon_Ia_Met; cd07957
195102008146	tRNA binding surface [nucleotide binding]; other site
195102008147	anticodon binding site; other site
195102008148	tRNA-binding-domain-containing Escherichia coli methionyl-tRNA synthetase (EcMetRS)-like proteins.  This family includes EcMetRS and Aquifex aeolicus Trbp111 (AaTrbp111). This domain has general tRNA binding properties.  MetRS aminoacylates methionine...; Region: tRNA_bind_EcMetRS_like; cd02800
195102008149	dimer interface [polypeptide binding]; other site
195102008150	putative tRNA-binding site [nucleotide binding]; other site
195102008151	Bacterial protein of unknown function (DUF939); Region: DUF939; pfam06081
195102008152	Bacterial protein of unknown function (DUF939); Region: DUF939; pfam06081
195102008153	Na+/H+ antiporter [Energy production and conversion]; Region: NhaC; COG1757
195102008154	Predicted unusual protein kinase [General function prediction only]; Region: AarF; COG0661
195102008155	ABC1 family; Region: ABC1; pfam03109
195102008156	Aminoglycoside 3'-phosphotransferase (APH) and Choline Kinase (ChoK) family. The APH/ChoK family is part of a larger superfamily that includes the catalytic domains of other kinases, such as the typical serine/threonine/tyrosine protein kinases (PKs)...; Region: APH_ChoK_like; cd05120
195102008157	active site
195102008158	ATP binding site [chemical binding]; other site
195102008159	Uncharacterized conserved protein [Function unknown]; Region: COG3937
195102008160	Aminopeptidase P, N-terminal domain; Region: AMP_N; smart01011
195102008161	proline aminopeptidase P II; Provisional; Region: PRK10879
195102008162	Prolidase. E.C. 3.4.13.9. Also known as Xaa-Pro dipeptidase, X-Pro dipeptidase, proline dipeptidase., imidodipeptidase, peptidase D, gamma-peptidase. Catalyses hydrolysis of Xaa-Pro dipeptides; also acts on aminoacyl-hydroxyproline analogs. No action on...; Region: Prolidase; cd01087
195102008163	active site
195102008164	bifunctional acetaldehyde-CoA/alcohol dehydrogenase; Provisional; Region: PRK13805
195102008165	Coenzyme A acylating aldehyde dehydrogenase (ACDH), ALDH family 20-like; Region: ALDH_F20_ACDH; cd07122
195102008166	putative catalytic cysteine [active]
195102008167	C-terminal alcohol dehydrogenase domain of the acetaldehyde dehydrogenase-alcohol dehydrogenase bifunctional two-domain protein (AAD); Region: AAD_C; cd08178
195102008168	putative active site [active]
195102008169	metal binding site [ion binding]; metal-binding site
195102008170	Uncharacterized membrane protein [Function unknown]; Region: SpmB; COG0700
195102008171	Uncharacterized membrane protein, required for spore maturation in B.subtilis. [General function prediction only]; Region: SpmA; COG2715
195102008172	SecA DEAD-like domain; Region: SecA_DEAD; smart00957
195102008173	Na+-driven multidrug efflux pump [Defense mechanisms]; Region: NorM; COG0534
195102008174	Subfamily of the multidrug and toxic compound extrusion (MATE)-like proteins similar to Streptococcus aureus MepA; Region: MATE_MepA_like; cd13143
195102008175	Cytochrome c biogenesis protein [Posttranslational modification, protein turnover, chaperones]; Region: CcdA; COG0785
195102008176	Cytochrome C biogenesis protein transmembrane region; Region: DsbD; cl15788
195102008177	TRX family; composed of two groups: Group I, which includes proteins that exclusively encode a TRX domain; and Group II, which are composed of fusion proteins of TRX and additional domains. Group I TRX is a small ancient protein that alter the redox...; Region: TRX_family; cd02947
195102008178	catalytic residues [active]
195102008179	Transcriptional regulators [Transcription]; Region: PurR; COG1609
195102008180	Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392
195102008181	DNA binding site [nucleotide binding]
195102008182	domain linker motif; other site
195102008183	Ligand binding domain of the LacI tanscriptional regulator family belonging to the type I periplasmic-binding fold protein superfamily; Region: PBP1_LacI_sugar_binding_like; cd06267
195102008184	dimerization interface [polypeptide binding]; other site
195102008185	ligand binding site [chemical binding]; other site
195102008186	Rhodanese Homology Domain (RHOD); an alpha beta fold domain found duplicated in the rhodanese protein. The cysteine containing enzymatically active version of the domain is also found in the Cdc25 class of protein phosphatases and a variety of proteins...; Region: RHOD; cd00158
195102008187	active site residue [active]
195102008188	isoleucyl-tRNA synthetase; Reviewed; Region: ileS; PRK06039
195102008189	catalytic core domain of isoleucyl-tRNA synthetases; Region: IleRS_core; cd00818
195102008190	HIGH motif; other site
195102008191	catalytic core domain of isoleucyl-tRNA synthetases; Region: IleRS_core; cd00818
195102008192	active site
195102008193	KMSKS motif; other site
195102008194	Anticodon-binding domain of archaeal, bacterial, and eukaryotic cytoplasmic isoleucyl tRNA synthetases; Region: Anticodon_Ia_Ile_ABEc; cd07961
195102008195	tRNA binding surface [nucleotide binding]; other site
195102008196	anticodon binding site; other site
195102008197	BFD-like [2Fe-2S] binding domain; Region: Fer2_BFD; cl01093
195102008198	ATPase components of ABC transporters with duplicated ATPase domains [General function prediction only]; Region: Uup; COG0488
195102008199	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
195102008200	Walker A/P-loop; other site
195102008201	ATP binding site [chemical binding]; other site
195102008202	Q-loop/lid; other site
195102008203	ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221
195102008204	ABC transporter signature motif; other site
195102008205	Walker B; other site
195102008206	D-loop; other site
195102008207	ABC transporter; Region: ABC_tran_2; pfam12848
195102008208	ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221
195102008209	putative proton-coupled thiamine transporter YuaJ; Region: thia_yuaJ; TIGR02357
195102008210	Putative transcription activator [Transcription]; Region: TenA; COG0819
195102008211	Predicted SAM-dependent methyltransferases [General function prediction only]; Region: COG1092
195102008212	Putative RNA-binding Domain in PseudoUridine synthase and Archaeosine transglycosylase; Region: PUA; smart00359
195102008213	Middle domain of the SAM-dependent methyltransferase RlmI and related proteins; Region: RlmI_M_like; cd11572
195102008214	putative RNA binding site [nucleotide binding]; other site
195102008215	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
195102008216	S-adenosylmethionine binding site [chemical binding]; other site
195102008217	Uncharacterized protein with conserved CXXC pairs [Function unknown]; Region: COG3862
195102008218	Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox_2; pfam07992
195102008219	Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070
195102008220	Predicted dehydrogenase [General function prediction only]; Region: COG0579
195102008221	hydroxyglutarate oxidase; Provisional; Region: PRK11728
195102008222	BFD-like [2Fe-2S] binding domain; Region: Fer2_BFD; pfam04324
195102008223	glycerol kinase; Provisional; Region: glpK; PRK00047
195102008224	Escherichia coli glycerol kinase-like proteins; belongs to the FGGY family of carbohydrate kinases; Region: FGGY_EcGK_like; cd07786
195102008225	N- and C-terminal domain interface [polypeptide binding]; other site
195102008226	active site
195102008227	MgATP binding site [chemical binding]; other site
195102008228	catalytic site [active]
195102008229	metal binding site [ion binding]; metal-binding site
195102008230	glycerol binding site [chemical binding]; other site
195102008231	homotetramer interface [polypeptide binding]; other site
195102008232	homodimer interface [polypeptide binding]; other site
195102008233	FBP binding site [chemical binding]; other site
195102008234	protein IIAGlc interface [polypeptide binding]; other site
195102008235	Glycerol-3-phosphate responsive antiterminator; Region: G3P_antiterm; cl00852
195102008236	Major intrinsic protein (MIP) superfamily. Members of the MIP superfamily function as membrane channels that selectively transport water, small neutral molecules, and ions out of and between cells. The channel proteins share a common fold: the N-terminal...; Region: MIP; cd00333
195102008237	amphipathic channel; other site
195102008238	Asn-Pro-Ala signature motifs; other site
195102008239	Platelet-activating factor acetylhydrolase, isoform II; Region: PAF-AH_p_II; pfam03403
195102008240	2-phosphosulfolactate phosphatase; Provisional; Region: PRK00886
195102008241	Phosphosulfolactate phosphohydrolase and related enzymes [Coenzyme metabolism / General function prediction only]; Region: COG2045
195102008242	Predicted Fe-S oxidoreductase [General function prediction only]; Region: COG1242
195102008243	Uncharacterized membrane protein [Function unknown]; Region: COG3949
195102008244	Putative peptidoglycan-binding domain-containing protein [Cell envelope biogenesis, outer membrane]; Region: COG3409
195102008245	Putative peptidoglycan binding domain; Region: PG_binding_1; pfam01471
195102008246	Peptidase S8 family domain in CspA-like proteins; Region: Peptidases_S8_CspA-like; cd07478
195102008247	active site
195102008248	catalytic triad [active]
195102008249	Subtilisin-like serine proteases [Posttranslational modification, protein turnover, chaperones]; Region: AprE; COG1404
195102008250	Peptidase S8 family domain in CspA-like proteins; Region: Peptidases_S8_CspA-like; cd07478
195102008251	active site
195102008252	catalytic triad [active]
195102008253	Peptidase S8 family domain in CspA-like proteins; Region: Peptidases_S8_CspA-like; cd07478
195102008254	active site
195102008255	catalytic triad [active]
195102008256	Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093
195102008257	non-specific DNA binding site [nucleotide binding]; other site
195102008258	salt bridge; other site
195102008259	sequence-specific DNA binding site [nucleotide binding]; other site
195102008260	Peptidase S24 LexA-like proteins are involved in the SOS response leading to the repair of single-stranded DNA within the bacterial cell. This family includes: the lambda repressor CI/C2 family and related bacterial prophage repressor proteins; LexA (EC...; Region: S24_LexA-like; cd06529
195102008261	Catalytic site [active]
195102008262	Domain of unknown function (DUF3783); Region: DUF3783; pfam12646
195102008263	cyclophilin: cyclophilin-type peptidylprolyl cis- trans isomerases. This family contains eukaryotic, bacterial and archeal proteins which exhibit a peptidylprolyl cis- trans isomerases activity (PPIase, Rotamase) and in addition bind the...; Region: cyclophilin; cd00317
195102008264	active site
195102008265	Domain of unknown function (DUF4325); Region: DUF4325; pfam14213
195102008266	glutamate racemase; Provisional; Region: PRK00865
195102008267	Glutamine synthetase [Amino acid transport and metabolism]; Region: GlnA; COG0174
195102008268	Glutamine synthetase, catalytic domain; Region: Gln-synt_C; pfam00120
195102008269	VanZ like family; Region: VanZ; cl01971
195102008270	carbamoyl phosphate synthase large subunit; Reviewed; Region: carB; PRK05294
195102008271	Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289
195102008272	Carbamoyl-phosphate synthase L chain, ATP binding domain; Region: CPSase_L_D2; pfam02786
195102008273	Carbamoyl-phosphate synthetase large chain, oligomerisation domain; Region: CPSase_L_D3; pfam02787
195102008274	Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289
195102008275	ATP-grasp domain; Region: ATP-grasp_4; cl17255
195102008276	Methylglyoxal synthase-like domain from type II glutamine-dependent carbamoyl phosphate synthetase (CSP). CSP, a CarA and CarB heterodimer, catalyzes the production of carbamoyl phosphate which is subsequently employed in the metabolic pathways...; Region: MGS_CPS_II; cd01424
195102008277	IMP binding site; other site
195102008278	dimer interface [polypeptide binding]; other site
195102008279	interdomain contacts; other site
195102008280	partial ornithine binding site; other site
195102008281	carbamoyl phosphate synthase small subunit; Reviewed; Region: PRK12564
195102008282	Carbamoyl-phosphate synthase small chain, CPSase domain; Region: CPSase_sm_chain; smart01097
195102008283	Small chain of the glutamine-dependent form of carbamoyl phosphate synthase, CPSase II; Region: GATase1_CPSase; cd01744
195102008284	catalytic site [active]
195102008285	subunit interface [polypeptide binding]; other site
195102008286	[FeFe] hydrogenase, group B1/B3; Region: FeFe_hydrog_B1; TIGR04105
195102008287	4Fe-4S binding domain; Region: Fer4; pfam00037
195102008288	Iron only hydrogenase large subunit, C-terminal domain; Region: Fe_hyd_lg_C; pfam02906
195102008289	Alkyladenine DNA glycosylase catalyzes the first step in base excision repair; Region: AAG; cd00540
195102008290	active site
195102008291	DNA binding site [nucleotide binding]
195102008292	PTS_IIA, PTS system, lactose/cellobiose specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_lac; cd00215
195102008293	methionine cluster; other site
195102008294	active site
195102008295	phosphorylation site [posttranslational modification]
195102008296	metal binding site [ion binding]; metal-binding site
195102008297	Gamma-glutamyl phosphate reductase (GPR), aldehyde dehydrogenase families 18 and 19; Region: ALDH_F18-19_ProA-GPR; cd07079
195102008298	gamma-glutamyl phosphate reductase; Region: proA; TIGR00407
195102008299	putative catalytic cysteine [active]
195102008300	gamma-glutamyl kinase; Provisional; Region: PRK05429
195102008301	AAK_G5K_ProB: Glutamate-5-kinase (G5K) catalyzes glutamate-dependent ATP cleavage; G5K transfers the terminal phosphoryl group of ATP to the gamma-carboxyl group of glutamate, in the first and controlling step of proline (and, in mammals, ornithine)...; Region: AAK_G5K_ProB; cd04242
195102008302	nucleotide binding site [chemical binding]; other site
195102008303	homotetrameric interface [polypeptide binding]; other site
195102008304	putative phosphate binding site [ion binding]; other site
195102008305	putative allosteric binding site; other site
195102008306	short chain dehydrogenase; Provisional; Region: PRK06701
195102008307	classical (c) SDR, subgroup 1; Region: SDR_c1; cd05355
195102008308	NAD binding site [chemical binding]; other site
195102008309	metal binding site [ion binding]; metal-binding site
195102008310	active site
195102008311	Short-chain dehydrogenases of various substrate specificities [General function prediction only]; Region: DltE; COG0300
195102008312	classical (c) SDRs; Region: SDR_c; cd05233
195102008313	NAD(P) binding site [chemical binding]; other site
195102008314	active site
195102008315	Xanthine/uracil/vitamin C permease [Nucleotide transport and    metabolism]; Region: COG2252
195102008316	Sulfate transporter family; Region: Sulfate_transp; pfam00916
195102008317	hybrid cluster protein; Provisional; Region: PRK05290
195102008318	The HCP family of iron-sulfur proteins includes hybrid cluster protein (HCP), acetyl-CoA synthase (ACS), and carbon monoxide dehydrogenase (CODH), all of which contain [Fe4-S4] metal clusters at their active sites. These proteins have a conserved...; Region: HCP_like; cl14655
195102008319	ACS interaction site; other site
195102008320	CODH interaction site; other site
195102008321	Hybrid cluster protein (HCP), formerly known as prismane, is thought to play a role in nitrogen metabolism but its specific function is unknown. HCP has three structural domains, an N-terminal alpha-helical domain, and two similar domains comprising a...; Region: HCP; cd01914
195102008322	hybrid metal cluster; other site
195102008323	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3314
195102008324	Nucleoside recognition; Region: Gate; pfam07670
195102008325	Staygreen protein; Region: Staygreen; pfam12638
195102008326	Protein of unknown function (DUF3888); Region: DUF3888; pfam13027
195102008327	maltose O-acetyltransferase; Provisional; Region: PRK10092
195102008328	Maltose O-acetyltransferase (MAT) and Galactoside O-acetyltransferase (GAT): MAT and GAT catalyze the CoA-dependent acetylation of the 6-hydroxyl group of their respective sugar substrates. MAT acetylates maltose and glucose exclusively at the C6...; Region: LbH_MAT_GAT; cd03357
195102008329	active site
195102008330	substrate binding site [chemical binding]; other site
195102008331	trimer interface [polypeptide binding]; other site
195102008332	CoA binding site [chemical binding]; other site
195102008333	methionine sulfoxide reductase A; Provisional; Region: PRK14054
195102008334	type II restriction m6 adenine DNA methyltransferase, Alw26I/Eco31I/Esp3I family; Region: met_A_Alw26; TIGR02987
195102008335	Predicted membrane protein [Function unknown]; Region: COG1511
195102008336	YhgE/Pip N-terminal domain; Region: pip_yhgE_Nterm; TIGR03061
195102008337	YhgE/Pip C-terminal domain; Region: pip_yhgE_Cterm; TIGR03062
195102008338	YhgE/Pip N-terminal domain; Region: pip_yhgE_Nterm; TIGR03061
195102008339	Predicted membrane protein [Function unknown]; Region: COG1511
195102008340	YhgE/Pip C-terminal domain; Region: pip_yhgE_Cterm; TIGR03062
195102008341	Uncharacterized Zn-ribbon-containing protein involved in phosphonate metabolism [Inorganic ion transport and metabolism]; Region: PhnA; COG2824
195102008342	PhnA Zinc-Ribbon; Region: PhnA_Zn_Ribbon; pfam08274
195102008343	PhnA protein; Region: PhnA; pfam03831
195102008344	Predicted DNA modification methylase [DNA replication, recombination, and repair]; Region: COG1041
195102008345	Kef-type K+ transport systems, membrane components [Inorganic ion transport and metabolism]; Region: KefB; COG0475
195102008346	NhaP-type Na+/H+ and K+/H+ antiporters [Inorganic ion transport and metabolism]; Region: NhaP; COG0025
195102008347	TrkA-C domain; Region: TrkA_C; pfam02080
195102008348	Membrane protein of unknown function; Region: DUF360; pfam04020
195102008349	Protein of unknown function (DUF2871); Region: DUF2871; pfam11070
195102008350	short chain dehydrogenase; Provisional; Region: PRK06701
195102008351	classical (c) SDR, subgroup 1; Region: SDR_c1; cd05355
195102008352	NAD binding site [chemical binding]; other site
195102008353	metal binding site [ion binding]; metal-binding site
195102008354	active site
195102008355	Probable zinc-binding domain; Region: zf-trcl; pfam13451
195102008356	rRNA large subunit methyltransferase; Provisional; Region: PRK00103
195102008357	TIGR03987 family protein; Region: TIGR03987
195102008358	Uncharacterized ACR, YkgG family COG1556; Region: DUF162; pfam02589
195102008359	hypothetical protein; Provisional; Region: PRK05590
195102008360	Sporulation and spore germination; Region: Germane; pfam10646
195102008361	Metal-dependent hydrolases of the beta-lactamase superfamily I [General function prediction only]; Region: PhnP; COG1235
195102008362	UDP-N-acetylglucosamine 1-carboxyvinyltransferase; Region: murA; TIGR01072
195102008363	UDP-N-acetylglucosamine enolpyruvyl transferase catalyzes enolpyruvyl transfer as part of the first step in the biosynthesis of peptidoglycan, a component of the bacterial cell wall. The reaction is phosphoenolpyruvate + UDP-N-acetyl-D-glucosamine =...; Region: UdpNAET; cd01555
195102008364	hinge; other site
195102008365	active site
195102008366	2'-5' RNA ligase superfamily; Region: 2_5_RNA_ligase2; pfam13563
195102008367	dUTPase; Region: dUTPase_2; pfam08761
195102008368	Nucleoside Triphosphate Pyrophosphohydrolase (EC 3.6.1.8) MazG-like domain found in dimeric 2-Deoxyuridine 5'-triphosphate nucleotidohydrolase and similar proteins; Region: NTP-PPase_dUTPase; cd11527
195102008369	active site
195102008370	homodimer interface [polypeptide binding]; other site
195102008371	metal binding site [ion binding]; metal-binding site
195102008372	Protein of unknown function, DUF606; Region: DUF606; pfam04657
195102008373	Subtilisin-like serine proteases [Posttranslational modification, protein turnover, chaperones]; Region: AprE; COG1404
195102008374	Peptidase domain in the S8 and S53 families; Region: Peptidases_S8_S53; cl10459
195102008375	active site
195102008376	catalytic residues [active]
195102008377	Membrane proteins related to metalloendopeptidases [Cell envelope biogenesis, outer membrane]; Region: NlpD; COG0739
195102008378	Peptidase family M23; Region: Peptidase_M23; pfam01551
195102008379	Replication initiation and membrane attachment; Region: DnaB_2; pfam07261
195102008380	Replication initiation and membrane attachment; Region: DnaB_2; cl12121
195102008381	DNA replication protein DnaC; Validated; Region: PRK06835
195102008382	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
195102008383	Walker A motif; other site
195102008384	ATP binding site [chemical binding]; other site
195102008385	Walker B motif; other site
195102008386	flavoprotein, HI0933 family; Region: TIGR00275
195102008387	NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500
195102008388	Acyl-ACP thioesterase; Region: Acyl-ACP_TE; pfam01643
195102008389	4-hydroxybenzoyl-CoA thioesterase (4HBT). Catalyzes the final step in the 4-chlorobenzoate degradation pathway in which 4-chlorobenzoate is converted to 4-hydroxybenzoate in certain soil-dwelling bacteria. 4HBT forms a homotetramer with four active sites; Region: 4HBT; cd00586
195102008390	active site
195102008391	Thioesterase-like superfamily; Region: 4HBT_2; pfam13279
195102008392	active site 2 [active]
195102008393	active site 1 [active]
195102008394	Acyl-ACP thioesterase; Region: Acyl-ACP_TE; pfam01643
195102008395	4-hydroxybenzoyl-CoA thioesterase (4HBT). Catalyzes the final step in the 4-chlorobenzoate degradation pathway in which 4-chlorobenzoate is converted to 4-hydroxybenzoate in certain soil-dwelling bacteria. 4HBT forms a homotetramer with four active sites; Region: 4HBT; cd00586
195102008396	active site
195102008397	Rubredoxin, Small Modular nonheme iron binding domain containing a [Fe(SCys)4] center, present in rubrerythrin and nigerythrin and detected either N- or C-terminal to such proteins as flavin reductase, NAD(P)H-nitrite reductase, and...; Region: rubredoxin_SM; cd00729
195102008398	Rubredoxin; Region: Rubredoxin; pfam00301
195102008399	iron binding site [ion binding]; other site
195102008400	rubrerythrin-like, diiron-binding domain; Region: Rubrerythrin_like; cd01046
195102008401	Rubrerythrin [Energy production and conversion]; Region: COG1592
195102008402	diiron binding motif [ion binding]; other site
195102008403	hybrid cluster protein-associated redox disulfide domain; Region: prismane_assoc; TIGR03980
195102008404	Nudix hydrolase is a superfamily of enzymes found in all three kingdoms of life, and it catalyzes the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+...; Region: Nudix_Hydrolase; cl00447
195102008405	nudix motif; other site
195102008406	Adenylosuccinate synthetase (AdSS) catalyzes the first step in the de novo biosynthesis of AMP. IMP and L-aspartate are conjugated in a two-step reaction accompanied by the hydrolysis of GTP to GDP in the presence of Mg2+. In the first step, the...; Region: AdSS; cd03108
195102008407	Adenylosuccinate synthetase; Region: Adenylsucc_synt; smart00788
195102008408	GDP-binding site [chemical binding]; other site
195102008409	ACT binding site; other site
195102008410	IMP binding site; other site
195102008411	L-serine dehydratase, iron-sulfur-dependent, beta subunit; Region: sda_beta; TIGR00719
195102008412	Serine dehydratase beta chain; Region: SDH_beta; pfam03315
195102008413	C-terminal ACT domain of the L-serine dehydratase (LSD), iron-sulfur-dependent, beta subunit; Region: ACT_LSD; cd04903
195102008414	putative L-serine binding site [chemical binding]; other site
195102008415	Serine dehydratase alpha chain; Region: SDH_alpha; cl12120
195102008416	L-serine deaminase [Amino acid transport and metabolism]; Region: SdaA; COG1760
195102008417	putative sugar isomerase, AgaS family; Region: agaS_fam; TIGR02815
195102008418	SIS (Sugar ISomerase) domain repeat 1 found in Glucosamine 6-phosphate synthase (GlmS) and Glucosamine-6-phosphate deaminase (GlmD). The SIS domain is found in many phosphosugar isomerases and phosphosugar binding proteins. GlmS contains a N-terminal...; Region: SIS_GlmS_GlmD_1; cd05008
195102008419	dimer interface [polypeptide binding]; other site
195102008420	active site
195102008421	AgaS-like protein. AgaS contains a SIS (Sugar ISomerase) domain which is found in many phosphosugar isomerases and phosphosugar binding proteins. AgaS is a putative isomerase in Escherichia coli. It is similar to the glucosamine-6-phosphate synthases; Region: SIS_AgaS_like; cd05010
195102008422	putative active site [active]
195102008423	Tagatose-1,6-bisphosphate (TBP) aldolase and related Type B Class II aldolases. TBP aldolase is a tetrameric class II aldolase that catalyzes the reversible condensation of dihydroxyacetone phosphate with glyceraldehyde 3-phsophate to produce tagatose 1; Region: TBP_aldolase_IIB; cd00947
195102008424	fructose-bisphosphate aldolase; Provisional; Region: PRK09197
195102008425	intersubunit interface [polypeptide binding]; other site
195102008426	active site
195102008427	zinc binding site [ion binding]; other site
195102008428	Na+ binding site [ion binding]; other site
195102008429	Transcriptional regulators [Transcription]; Region: PhnF; COG2188
195102008430	Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377
195102008431	DNA-binding site [nucleotide binding]; DNA binding site
195102008432	UTRA domain; Region: UTRA; pfam07702
195102008433	Preprotein translocase subunit; Region: YajC; cl00806
195102008434	PTS_IIA, PTS system, mannose/sorbose specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIA_man; cd00006
195102008435	active pocket/dimerization site; other site
195102008436	active site
195102008437	phosphorylation site [posttranslational modification]
195102008438	PTS system mannose/fructose/sorbose family IID component; Region: EIID-AGA; pfam03613
195102008439	PTS system sorbose-specific iic component; Region: EII-Sor; pfam03609
195102008440	PTS_IIB, PTS system, Mannose/sorbose specific IIB subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIB_man; cd00001
195102008441	active site
195102008442	phosphorylation site [posttranslational modification]
195102008443	pyrroline-5-carboxylate reductase; Reviewed; Region: PRK11880
195102008444	pyrroline-5-carboxylate reductase; Region: PLN02688
195102008445	replicative DNA helicase; Provisional; Region: PRK05595
195102008446	DnaB-like helicase N terminal domain; Region: DnaB; pfam00772
195102008447	DnaB helicase C terminal domain. The hexameric helicase DnaB unwinds the DNA duplex at the  chromosome replication fork. Although the mechanism by which DnaB both couples ATP hydrolysis to translocation along DNA and denatures the duplex is unknown, a...; Region: DnaB_C; cd00984
195102008448	Walker A motif; other site
195102008449	ATP binding site [chemical binding]; other site
195102008450	Walker B motif; other site
195102008451	DNA binding loops [nucleotide binding]
195102008452	ATP-dependent protease, Lon family; Region: spore_lon_C; TIGR02903
195102008453	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
195102008454	Walker A motif; other site
195102008455	ATP binding site [chemical binding]; other site
195102008456	Walker B motif; other site
195102008457	arginine finger; other site
195102008458	Lon protease (S16) C-terminal proteolytic domain; Region: Lon_C; pfam05362
195102008459	50S ribosomal protein L9; Reviewed; Region: rplI; PRK00137
195102008460	Ribosomal protein L9, N-terminal domain; Region: Ribosomal_L9_N; pfam01281
195102008461	Ribosomal protein L9, C-terminal domain; Region: Ribosomal_L9_C; pfam03948
195102008462	Predicted signaling protein consisting of a modified GGDEF domain and a DHH domain [Signal transduction mechanisms]; Region: COG3887
195102008463	DHH family; Region: DHH; pfam01368
195102008464	DHHA1 domain; Region: DHHA1; pfam02272
195102008465	Predicted membrane protein (DUF2232); Region: DUF2232; pfam09991
195102008466	MazG-like family; Region: MazG-like; pfam12643
195102008467	30S ribosomal protein S18; Reviewed; Region: rpsR; PRK00391
195102008468	Single-stranded DNA-binding protein [DNA replication, recombination, and repair]; Region: Ssb; COG0629
195102008469	SSB_OBF: A subfamily of OB folds similar to the OB fold of ssDNA-binding protein (SSB). SSBs bind with high affinity to ssDNA. They bind to and protect ssDNA intermediates during DNA metabolic pathways. All bacterial and eukaryotic SSBs studied to date...; Region: SSB_OBF; cd04496
195102008470	dimer interface [polypeptide binding]; other site
195102008471	ssDNA binding site [nucleotide binding]; other site
195102008472	tetramer (dimer of dimers) interface [polypeptide binding]; other site
195102008473	30S ribosomal protein S6; Reviewed; Region: rpsF; PRK00453
195102008474	Bacterial protein of unknown function (DUF951); Region: DUF951; pfam06107
195102008475	Small-conductance mechanosensitive channel [Cell envelope biogenesis, outer membrane]; Region: MscS; COG0668
195102008476	Mechanosensitive ion channel; Region: MS_channel; pfam00924
195102008477	Protein of unknown function (DUF3343); Region: DUF3343; pfam11823
195102008478	LysE type translocator; Region: LysE; cl00565
195102008479	Selenocysteine lyase/Cysteine desulfurase [Posttranslational modification, protein turnover, chaperones]; Region: csdA; COG0520
195102008480	cysteine desulfurase family protein; Region: am_tr_V_EF2568; TIGR01977
195102008481	pyridoxal 5'-phosphate binding pocket [chemical binding]; other site
195102008482	catalytic residue [active]
195102008483	Predicted permease, member of the PurR regulon [General function prediction only]; Region: yhhT; cl00465
195102008484	putative sporulation protein YyaC; Region: spore_YyaC; TIGR02841
195102008485	ParB/RepB/Spo0J family partition protein; Region: parB_part; TIGR00180
195102008486	ParB-like nuclease domain; Region: ParB; smart00470
195102008487	ATPases involved in chromosome partitioning [Cell division and chromosome partitioning]; Region: Soj; COG1192
195102008488	ParA and ParB of Caulobacter crescentus belong to a conserved family of bacterial proteins implicated in chromosome segregation. ParB binds to DNA sequences adjacent to the origin of replication and localizes to opposite cell poles shortly following the...; Region: ParA; cd02042
195102008489	P-loop; other site
195102008490	Magnesium ion binding site [ion binding]; other site
195102008491	ParA and ParB of Caulobacter crescentus belong to a conserved family of bacterial proteins implicated in chromosome segregation. ParB binds to DNA sequences adjacent to the origin of replication and localizes to opposite cell poles shortly following the...; Region: ParA; cd02042
195102008492	Magnesium ion binding site [ion binding]; other site
195102008493	Predicted S-adenosylmethionine-dependent methyltransferase involved in bacterial cell division [Cell envelope biogenesis, outer membrane]; Region: GidB; COG0357
195102008494	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
195102008495	S-adenosylmethionine binding site [chemical binding]; other site
195102008496	tRNA uridine 5-carboxymethylaminomethyl modification enzyme GidA; Validated; Region: PRK05192
195102008497	tRNA (uracil-5-)-methyltransferase Gid; Reviewed; Region: PRK05335
195102008498	GidA associated domain 3; Region: GIDA_assoc_3; pfam13932
195102008499	tRNA modification GTPase TrmE; Reviewed; Region: trmE; PRK05291
195102008500	GTP-binding protein TrmE N-terminus; Region: TrmE_N; pfam10396
195102008501	trmE is a tRNA modification GTPase; Region: trmE; cd04164
195102008502	G1 box; other site
195102008503	GTP/Mg2+ binding site [chemical binding]; other site
195102008504	Switch I region; other site
195102008505	G2 box; other site
195102008506	Switch II region; other site
195102008507	G3 box; other site
195102008508	G4 box; other site
195102008509	G5 box; other site
195102008510	Catalytic cysteine-containing C-terminus of GTPase, MnmE; Region: GTPase_Cys_C; pfam12631
195102008511	Predicted RNA-binding protein [General function prediction only]; Region: Jag; COG1847
195102008512	jag_K homology RNA-binding domain. The KH domain is found in proteins homologous to the Bacillus subtilis protein Jag, which is associated with SpoIIIJ and is necessary for the third stage of sporulation.  The KH motif is a beta-alpha-alpha-beta-beta...; Region: jag_KH; cd02414
195102008513	G-X-X-G motif; other site
195102008514	R3H domain found in proteins homologous to Bacillus subtilus Jag, which is associated with SpoIIIJ. SpoIIIJ is necessary for the third stage of sporulation. The name of the R3H domain comes from the characteristic spacing of the most conserved arginine...; Region: R3H_jag; cd02644
195102008515	RxxxH motif; other site
195102008516	putative inner membrane protein translocase component YidC; Provisional; Region: PRK00145
195102008517	Haemolytic domain; Region: Haemolytic; pfam01809
195102008518	ribonuclease P; Reviewed; Region: rnpA; PRK00499
195102008519	50S ribosomal protein L34; Reviewed; Region: rpmH; PRK00399