-- dump date 20140619_044526 -- class Genbank::CDS -- table cds_note -- id note YP_002470411.1 homology (Evalue<1e-4) to COG1511 [S] Predicted membrane protein YP_002470418.1 homology (Evalue<1e-4) to COG3757 [M] Lyzozyme M1 (1,4-beta-N-acetylmuramidase) YP_002470420.1 homology (Evalue<1e-4) to COG0338 [L] Site-specific DNA methylase YP_002470424.1 homology (Evalue<1e-4) to COG1674 [D] DNA segregation ATPase FtsK/SpoIIIE and related proteins YP_002470426.1 homology (Evalue<1e-4) to COG2436 [S] Uncharacterized ACR YP_002470428.1 homology (Evalue<1e-4) to COG1598 [S] Uncharacterized ACR YP_002470430.1 3'-5' exonuclease of DNA polymerase III YP_002470431.1 homology (Evalue<1e-4) to COG1396 [K] Predicted transcriptional regulators YP_002470432.1 homology (Evalue<1e-4) to COG1396 [K] Predicted transcriptional regulators YP_002470439.1 homology (Evalue<1e-4) to COG0419 [L] ATPase involved in DNA repair YP_002470441.1 homology (Evalue<1e-4) to COG0629 [L] Single-stranded DNA-binding protein YP_002470443.1 homology (Evalue<1e-4) to COG0338 [L] Site-specific DNA methylase YP_002470450.1 homology (Evalue<1e-4) to COG0358 [L] DNA primase (bacterial type) YP_002470454.1 homology (Evalue<1e-4) to COG3747 [S] Uncharacterized phage protein YP_002470455.1 homology (Evalue<1e-4) to COG0553 [KL] Superfamily II DNA/RNA helicases, SNF2 family YP_002470457.1 homology (Evalue<1e-4) to COG0740 [NO] Protease subunit of ATP-dependent Clp proteases YP_002470466.1 binds to the dnaA-box as an ATP-bound complex at the origin of replication during the initiation of chromosomal replication; can also affect transcription of multiple genes including itself. YP_002470467.1 binds the polymerase to DNA and acts as a sliding clamp YP_002470468.1 homology (Evalue<1e-4) to COG2501 [S] Uncharacterized ACR YP_002470469.1 Required for DNA replication; binds preferentially to single-stranded, linear DNA YP_002470471.1 negatively supercoils closed circular double-stranded DNA YP_002470472.1 negatively supercoils closed circular double-stranded DNA YP_002470474.1 homology (Evalue<1e-4) to COG1827 [R] Predicted small molecule binding protein (contains 3H domain) YP_002470475.1 homology (Evalue<1e-4) to COG1615 [S] Uncharacterized ACR YP_002470476.1 homology (Evalue<1e-4) to COG0579 [R] Predicted dehydrogenase YP_002470478.1 catalyzes a two-step reaction, first charging a serine molecule by linking its carboxyl group to the alpha-phosphate of ATP, followed by transfer of the aminoacyl-adenylate to its tRNA YP_002470479.1 homology (Evalue<1e-4) to COG0745 [TK] Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain YP_002470480.1 homology (Evalue<1e-4) to COG0642 [T] Signal transduction histidine kinase YP_002470482.1 homology (Evalue<1e-4) to COG1686 [M] D-alanyl-D-alanine carboxypeptidase YP_002470484.1 homology (Evalue<1e-4) to COG3547 [L] Transposase YP_002470486.1 homology (Evalue<1e-4) to COG0491 [R] Zn-dependent hydrolases, including glyoxylases YP_002470488.1 homology (Evalue<1e-4) to COG3344 [L] Retron-type reverse transcriptase YP_002470491.1 homology (Evalue<1e-4) to COG1131 [Q] ABC-type multidrug transport system, ATPase component YP_002470492.1 homology (Evalue<1e-4) to COG1277 [R] ABC-type transport system involved in multi-copper enzyme maturation, permease component YP_002470493.1 homology (Evalue<1e-4) to COG0642 [T] Signal transduction histidine kinase YP_002470494.1 homology (Evalue<1e-4) to COG0745 [TK] Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain YP_002470495.1 homology (Evalue<1e-4) to COG1408 [R] Predicted phosphohydrolases YP_002470497.1 homology (Evalue<1e-4) to COG2246 [S] Uncharacterized membrane protein YP_002470498.1 homology (Evalue<1e-4) to COG0583 [K] Transcriptional regulator YP_002470499.1 catalyzes the formation of citrate from acetyl-CoA and oxaloacetate YP_002470501.1 homology (Evalue<1e-4) to COG1734 [T] DnaK suppressor protein YP_002470502.1 homology (Evalue<1e-4) to COG0119 [E] Isopropylmalate/homocitrate/citramalate synthases YP_002470503.1 homology (Evalue<1e-4) to COG0454 [KR] Histone acetyltransferase HPA2 and related acetyltransferases YP_002470504.1 catalyzes the decarboxylaton of phospatidyl-L-sering to phosphatidylethanolamine YP_002470505.1 homology (Evalue<1e-4) to COG1309 [K] Transcriptional regulator YP_002470506.1 homology (Evalue<1e-4) to COG0661 [R] Predicted unusual protein kinase YP_002470508.1 homology (Evalue<1e-4) to COG0590 [FJ] Cytosine/adenosine deaminases YP_002470510.1 homology (Evalue<1e-4) to COG1476 [K] Predicted transcriptional regulators YP_002470512.1 homology (Evalue<1e-4) to COG1853 [R] Conserved protein/domain typically associated with flavoprotein oxygenases, DIM6/NTAB family YP_002470515.1 homology (Evalue<1e-4) to COG1917 [S] Uncharacterized ACR, double-stranded beta-helix domain YP_002470517.1 homology (Evalue<1e-4) to COG0574 [G] Phosphoenolpyruvate synthase/pyruvate phosphate dikinase YP_002470518.1 homology (Evalue<1e-4) to COG1309 [K] Transcriptional regulator YP_002470520.1 homology (Evalue<1e-4) to COG1595 [K] DNA-directed RNA polymerase specialized sigma subunits, sigma24 homologs YP_002470521.1 homology (Evalue<1e-4) to COG1132 [Q] ABC-type multidrug/protein/lipid transport system, ATPase component YP_002470522.1 homology (Evalue<1e-4) to COG1132 [Q] ABC-type multidrug/protein/lipid transport system, ATPase component YP_002470523.1 homology (Evalue<1e-4) to COG2826 [L] Transposase, IS30 family YP_002470525.1 homology (Evalue<1e-4) to COG3655 [K] Predicted transcriptional regulator YP_002470526.1 homology (Evalue<1e-4) to COG3315 [Q] O-Methyltransferase involved in polyketide biosynthesis YP_002470527.1 homology (Evalue<1e-4) to COG3315 [Q] O-Methyltransferase involved in polyketide biosynthesis YP_002470528.1 homology (Evalue<1e-4) to COG1846 [K] Transcriptional regulators YP_002470529.1 homology (Evalue<1e-4) to COG0477 [GEPR] Permeases of the major facilitator superfamily YP_002470530.1 homology (Evalue<1e-4) to COG2217 [P] Cation transport ATPases YP_002470531.1 homology (Evalue<1e-4) to COG2217 [P] Cation transport ATPases YP_002470532.1 homology (Evalue<1e-4) to COG1937 [S] Uncharacterized BCR YP_002470533.1 catalyzes the removal of amino acids from the N termini of peptides YP_002470534.1 homology (Evalue<1e-4) to COG2509 [R] Uncharacterized FAD-dependent dehydrogenases YP_002470535.1 catalyzes the formation of N6-(1,2,-dicarboxyethyl)-AMP from L-aspartate, inosine monophosphate and GTP in AMP biosynthesis YP_002470537.1 homology (Evalue<1e-4) to COG2081 [R] Predicted flavoproteins YP_002470538.1 homology (Evalue<1e-4) to COG1832 [R] Predicted CoA-binding protein YP_002470539.1 acts to load the DnaB helicase onto the initiation site during DNA replication YP_002470541.1 homology (Evalue<1e-4) to COG2070 [R] Dioxygenases related to 2-nitropropane dioxygenase YP_002470542.1 homology (Evalue<1e-4) to COG1846 [K] Transcriptional regulators YP_002470543.1 homology (Evalue<1e-4) to COG0332 [I] 3-oxoacyl-acyl-carrier-protein synthase III YP_002470544.1 homology (Evalue<1e-4) to COG0236 [IQ] Acyl carrier protein YP_002470545.1 homology (Evalue<1e-4) to COG2070 [R] Dioxygenases related to 2-nitropropane dioxygenase YP_002470546.1 homology (Evalue<1e-4) to COG0331 [I] (acyl-carrier-protein) S-malonyltransferase YP_002470547.1 homology (Evalue<1e-4) to COG1028 [QR] Dehydrogenases with different specificities (related to short-chain alcohol dehydrogenases) YP_002470548.1 FabF; beta-ketoacyl-ACP synthase II, KASII; catalyzes a condensation reaction in fatty acid biosynthesis: addition of an acyl acceptor of two carbons from malonyl-ACP; required for the elongation of short-chain unsaturated acyl-ACP YP_002470549.1 homology (Evalue<1e-4) to COG0511 [I] Biotin carboxyl carrier protein YP_002470550.1 in Pseudomonas aeruginosa this enzyme is a trimer of dimers; essential for membrane formation; performs third step of type II fatty acid biosynthesis; catalyzes dehydration of (3R)-hydroxyacyl-ACP to trans-2-acyl-ACP YP_002470551.1 homology (Evalue<1e-4) to COG0439 [I] Biotin carboxylase YP_002470552.1 homology (Evalue<1e-4) to COG0777 [I] Acetyl-CoA carboxylase beta subunit YP_002470553.1 catalyzes the carboxylation of acetyl-CoA to malonyl-CoA; forms a tetramer composed of two alpha (AccA) and two beta (AccD) subunits; one of the two catalytic subunits that can form the acetyl CoA carboxylase enzyme together with a carrier protein YP_002470554.1 homology (Evalue<1e-4) to COG1528 [P] Ferritin-like protein YP_002470555.1 homology (Evalue<1e-4) to COG1404 [O] Subtilisin-like serine proteases YP_002470556.1 homology (Evalue<1e-4) to COG3238 [S] Uncharacterized BCR YP_002470559.1 catalyzes a two-step reaction, first charging an asparagine molecule by linking its carboxyl group to the alpha-phosphate of ATP, followed by transfer of the aminoacyl-adenylate to its tRNA YP_002470560.1 homology (Evalue<1e-4) to COG0350 [L] Methylated DNA-protein cysteine methyltransferase YP_002470562.1 homology (Evalue<1e-4) to COG0419 [L] ATPase involved in DNA repair YP_002470563.1 homology (Evalue<1e-4) to COG0420 [L] DNA repair exonuclease YP_002470564.1 homology (Evalue<1e-4) to COG0653 [N] Preprotein translocase subunit SecA (ATPase, RNA helicase) YP_002470566.1 homology (Evalue<1e-4) to COG1235 [R] Metal-dependent hydrolases of the beta-lactamase superfamily I YP_002470567.1 adds enolpyruvyl to UDP-N-acetylglucosamine as a component of cell wall formation; gram-positive bacteria have 2 copies of MurA which are active YP_002470570.1 homology (Evalue<1e-4) to COG0174 [E] Glutamine synthase YP_002470571.1 converts L-glutamate to D-glutamate, a component of peptidoglycan YP_002470573.1 homology (Evalue<1e-4) to COG0840 [N] Methyl-accepting chemotaxis protein YP_002470574.1 homology (Evalue<1e-4) to COG1313 [R] Uncharacterized Fe-S protein PflX, homolog of pyruvate formate lyase activating proteins YP_002470575.1 homology (Evalue<1e-4) to COG0733 [R] Na+-dependent transporters of the SNF family YP_002470577.1 homology (Evalue<1e-4) to COG1242 [R] Uncharacterized Fe-S oxidoreductases YP_002470578.1 catalyzes the formation of (2R)-3-sulfolactate from (2R)-2-phospho-3-sulfolactate YP_002470580.1 homology (Evalue<1e-4) to COG0637 [R] Predicted phosphatase/phosphohexomutase YP_002470581.1 homology (Evalue<1e-4) to COG1034 [C] NADH dehydrogenase/NADH:ubiquinone oxidoreductase 75 kD subunit (chain G) YP_002470583.1 Catalyzes the formation of UDP-N-acetylmuramoyl-L-alanine from UDP-N-acetylmuramate and L-alanine in peptidoglycan synthesis YP_002470584.1 homology (Evalue<1e-4) to COG0503 [F] Adenine/guanine phosphoribosyltransferases and related PRPP-binding proteins YP_002470585.1 stage V sporulation protein G; essential for spore formation and a negative regulator of asymmetric septation in Bacillus; involved in methicillin-resistance, biofilm formation and capsular polysaccharide synthesis in Staphylococcus YP_002470586.1 forms a homotrimer; catalyzes the acetylation of glucosamine-1-phosphate and uridylation of N-acetylglucosamine-1-phosphate to produce UDP-GlcNAc; function in cell wall synthesis YP_002470587.1 catalyzes the formation of 5-phospho-alpha-D-ribose 1-phosphate from D-ribose 5-phosphate and ATP YP_002470588.1 homology (Evalue<1e-4) to COG0745 [TK] Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain YP_002470589.1 homology (Evalue<1e-4) to COG0642 [T] Signal transduction histidine kinase YP_002470590.1 homology (Evalue<1e-4) to COG0265 [O] Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain YP_002470591.1 Enables the recycling of peptidyl-tRNAs produced at termination of translation YP_002470592.1 homology (Evalue<1e-4) to COG1197 [LK] Transcription-repair coupling factor - superfamily II helicase YP_002470593.1 cis/trans isomerase of peptidylprolyl; PPIase; membrane-bound lipoprotein YP_002470594.1 homology (Evalue<1e-4) to COG2002 [K] Regulators of stationary/sporulation gene expression YP_002470595.1 homology (Evalue<1e-4) to COG2244 [R] Membrane protein involved in the export of O-antigen and teichoic acid YP_002470596.1 homology (Evalue<1e-4) to COG1694 [R] Predicted pyrophosphatase YP_002470597.1 homology (Evalue<1e-4) to COG0776 [L] Bacterial nucleoid DNA-binding protein YP_002470598.1 homology (Evalue<1e-4) to COG1188 [J] Ribosome-associated heat shock protein implicated in the recycling of the 50S subunit (S4 paralog) YP_002470602.1 homology (Evalue<1e-4) to COG1098 [J] Ribosomal protein S1 domains YP_002470603.1 homology (Evalue<1e-4) to COG2208 [TK] Serine phosphatase RsbU, regulator of sigma subunit YP_002470604.1 homology (Evalue<1e-4) to COG0037 [D] Predicted ATPase of the PP-loop superfamily implicated in cell cycle control YP_002470605.1 homology (Evalue<1e-4) to COG0634 [F] Hypoxanthine-guanine phosphoribosyltransferase YP_002470606.1 homology (Evalue<1e-4) to COG0465 [O] ATP-dependent Zn proteases YP_002470608.1 type III; catalyzes the formation of (R)-4'-phosphopantothenate from (R)-pantothenate in coenzyme A biosynthesis; type III pantothenate kinases are not subject to feedback inhibition from coenzyme A and have a high Km for ATP YP_002470609.1 homology (Evalue<1e-4) to COG0042 [R] Predicted TIM-barrel enzymes, possibly dehydrogenases, nifR3 family YP_002470611.1 necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites; arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus YP_002470612.1 class II; LysRS2; catalyzes a two-step reaction, first charging a lysine molecule by linking its carboxyl group to the alpha-phosphate of ATP, followed by transfer of the aminoacyl-adenylate to its tRNA; in Methanosarcina barkeri, LysRS2 charges both tRNA molecules for lysine that exist in this organism and in addition can charge the tRNAPyl with lysine in the presence of LysRS1 YP_002470613.1 Catalyzes a two-step reaction, first charging a glycine molecule by linking its carboxyl group to the alpha-phosphate of ATP, followed by transfer of the aminoacyl-adenylate to its tRNA YP_002470614.1 UDP-N-acetylmuramoylalanine--D-glutamate ligase; involved in peptidoglycan biosynthesis; cytoplasmic; catalyzes the addition of glutamate to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanine during cell wall formation YP_002470615.1 EF-G; promotes GTP-dependent translocation of the ribosome during translation; many organisms have multiple copies of this gene YP_002470617.1 homology (Evalue<1e-4) to COG0406 [G] Fructose-2,6-bisphosphatase YP_002470619.1 homology (Evalue<1e-4) to COG0556 [L] Helicase subunit of the DNA excision repair complex YP_002470621.1 homology (Evalue<1e-4) to COG0542 [O] ATPases with chaperone activity, ATP-binding subunit YP_002470622.1 Sms; stabilizes the strand-invasion intermediate during the DNA repair; involved in recombination of donor DNA and plays an important role in DNA damage repair after exposure to mutagenic agents YP_002470623.1 non-specific DNA-binding; scans chromosomes during sporulation for DNA-damage; delays initiation of sporulation; participates in a checkpoint signaling cascade for cell-cycle progression and DNA repair YP_002470625.1 homology (Evalue<1e-4) to COG1855 [R] ATPases of the PilT family YP_002470626.1 4-diphosphocytidyl-2C-methyl-D-erythritol synthase; MEP cytidylyltransferase; MCT; catalyzes the formation of 4-diphosphocytidyl-2-C-methyl-D-erythritol from CTP and 2-C-methyl-D-erythritol 4-phosphate; involved in isoprenoid and isopentenyl-PP biosynthesis; forms homodimers YP_002470627.1 catalyzes a two-step reaction; charges a cysteine by linking its carboxyl group to the alpha-phosphate of ATP then transfers the aminoacyl-adenylate to its tRNA YP_002470628.1 homology (Evalue<1e-4) to COG1939 [S] Uncharacterized BCR YP_002470629.1 homology (Evalue<1e-4) to COG0566 [J] rRNA methylases YP_002470630.1 homology (Evalue<1e-4) to COG3688 [R] Predicted RNA-binding protein containing a PIN domain YP_002470631.1 DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates YP_002470632.1 EF-Tu; promotes GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis; when the tRNA anticodon matches the mRNA codon, GTP hydrolysis results; the inactive EF-Tu-GDP leaves the ribosome and release of GDP is promoted by elongation factor Ts; many prokaryotes have two copies of the gene encoding EF-Tu YP_002470633.1 in Escherichia coli BM108, a mutation that results in lack of L33 synthesis had no effect on ribosome synthesis or function; there are paralogous genes in several bacterial genomes, and a CXXC motif for zinc binding and an upstream regulation region of the paralog lacking this motif that are regulated by zinc similar to other ribosomal proteins like L31; the proteins in this group have the CXXC motif YP_002470634.1 homology (Evalue<1e-4) to COG0690 [N] Preprotein translocase subunit SecE YP_002470635.1 Modulates Rho-dependent transcription termination YP_002470636.1 binds directly to 23S ribosomal RNA YP_002470637.1 in Escherichia coli and Methanococcus, this protein autoregulates expression; the binding site in the mRNA mimics the binding site in the 23S rRNA YP_002470638.1 binds the two ribosomal protein L7/L12 dimers and anchors them to the large ribosomal subunit YP_002470639.1 present in two forms; L12 is normal, while L7 is aminoacylated at the N-terminal serine; the only multicopy ribosomal protein; 4:1 ratio of L7/L12 per ribosome; two L12 dimers bind L10; critically important for translation efficiency and fidelity; stimulates GTPase activity of translation factors YP_002470640.1 DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates; beta subunit is part of the catalytic core which binds with a sigma factor to produce the holoenzyme YP_002470641.1 DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates. Subunit beta' binds to sigma factor allowing it to bind to the -10 region of the promoter YP_002470642.1 homology (Evalue<1e-4) to COG1358 [J] Ribosomal protein HS6-type (S12/L30/L7a) YP_002470643.1 interacts with and stabilizes bases of the 16S rRNA that are involved in tRNA selection in the A site and with the mRNA backbone; located at the interface of the 30S and 50S subunits, it traverses the body of the 30S subunit contacting proteins on the other side; mutations in the S12 gene confer streptomycin resistance YP_002470644.1 binds directly to 16S rRNA where it nucleates assembly of the head domain of the 30S subunit YP_002470645.1 EF-G; promotes GTP-dependent translocation of the ribosome during translation; many organisms have multiple copies of this gene YP_002470646.1 EF-Tu; promotes GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis; when the tRNA anticodon matches the mRNA codon, GTP hydrolysis results; the inactive EF-Tu-GDP leaves the ribosome and release of GDP is promoted by elongation factor Ts; many prokaryotes have two copies of the gene encoding EF-Tu YP_002470647.1 NusE; involved in assembly of the 30S subunit; in the ribosome, this protein is involved in the binding of tRNA; in Escherichia coli this protein was also found to be involved in transcription antitermination; NusB/S10 heterodimers bind boxA sequences in the leader RNA of rrn operons which is required for antitermination; binding of NusB/S10 to boxA nucleates assembly of the antitermination complex YP_002470648.1 binds directly near the 3' end of the 23S rRNA, where it nucleates assembly of the 50S subunit; essential for peptidyltransferase activity; mutations in this gene confer resistance to tiamulin YP_002470649.1 L4 is important during the early stages of 50S assembly; it initially binds near the 5' end of the 23S rRNA YP_002470650.1 binds third domain of 23S rRNA and protein L29; part of exit tunnel YP_002470651.1 one of the primary rRNA-binding proteins; required for association of the 30S and 50S subunits to form the 70S ribosome, for tRNA binding and peptide bond formation YP_002470652.1 protein S19 forms a complex with S13 that binds strongly to the 16S ribosomal RNA YP_002470653.1 binds specifically to 23S rRNA during the early stages of 50S assembly; makes contact with all 6 domains of the 23S rRNA in the assembled 50S subunit and ribosome; mutations in this gene result in erythromycin resistance; located near peptidyl-transferase center YP_002470654.1 forms a complex with S10 and S14; binds the lower part of the 30S subunit head and the mRNA in the complete ribosome to position it for translation YP_002470655.1 located in the peptidyl transferase center and may be involved in peptidyl transferase activity; similar to archaeal L10e YP_002470656.1 one of the stabilizing components for the large ribosomal subunit YP_002470657.1 primary binding protein; helps mediate assembly; involved in translation fidelity YP_002470658.1 binds to the 23S rRNA between the centers for peptidyl transferase and GTPase YP_002470659.1 assembly initiator protein; binds to 5' end of 23S rRNA and nucleates assembly of the 50S; surrounds polypeptide exit tunnel YP_002470660.1 part of 50S and 5S/L5/L18/L25 subcomplex; contacts 5S rRNA and P site tRNA; forms a bridge to the 30S subunit in the ribosome by binding to S13 YP_002470661.1 located in the peptidyl transferase center and involved in assembly of 30S ribosome subunit; similar to what is observed with proteins L31 and L33, some proteins in this family contain CXXC motifs that are involved in zinc binding; if two copies are present in a genome, then the duplicated copy appears to have lost the zinc-binding motif and is instead regulated by zinc; the proteins in this group appear to contain the zinc-binding motif YP_002470662.1 binds directly to 16S rRNA central domain where it helps coordinate assembly of the platform of the 30S subunit YP_002470663.1 ribosomal protein L6 appears to have arisen as a result of an ancient gene duplication as based on structural comparison of the Bacillus stearothermophilus protein; RNA-binding appears to be in the C-terminal domain; mutations in the L6 gene confer resistance to aminoglycoside antibiotics such as gentamicin and these occur in truncations of the C-terminal domain; it has been localized to a region between the base of the L7/L12 stalk and the central protuberance YP_002470664.1 binds 5S rRNA along with protein L5 and L25 YP_002470665.1 located at the back of the 30S subunit body where it stabilizes the conformation of the head with respect to the body; contacts S4 and S8; with S4 and S12 plays a role in translational accuracy; mutations in this gene result in spectinomycin resistance YP_002470666.1 L30 binds domain II of the 23S rRNA and the 5S rRNA; similar to eukaryotic protein L7 YP_002470667.1 late assembly protein YP_002470668.1 forms heterotrimeric complex in the membrane; in bacteria the complex consists of SecY which forms the channel pore and SecE and SecG; the SecG subunit is not essential; in bacteria translocation is driven via the SecA ATPase YP_002470669.1 essential enzyme that recycles AMP in active cells; converts ATP and AMP to two molecules of ADP YP_002470670.1 homology (Evalue<1e-4) to COG0024 [J] Methionine aminopeptidase YP_002470671.1 stimulates the activities of the other two initiation factors, IF-2 and IF-3 YP_002470672.1 smallest protein in the large subunit; similar to what is found with protein L31 and L33 several bacterial genomes contain paralogs which may be regulated by zinc; the protein from Thermus thermophilus has a zinc-binding motif and contains a bound zinc ion; the proteins in this group have the motif YP_002470673.1 located at the top of the head of the 30S subunit, it contacts several helices of the 16S rRNA; makes contact with the large subunit via RNA-protein interactions and via protein-protein interactions with L5; contacts P-site tRNA YP_002470674.1 located on the platform of the 30S subunit, it bridges several disparate RNA helices of the 16S rRNA; forms part of the Shine-Dalgarno cleft in the 70S ribosome; interacts with S7 and S18 and IF-3 YP_002470675.1 primary rRNA binding protein; nucleates 30S assembly; involved in translational accuracy with proteins S5 and S12; interacts with protein S5; involved in autogeneously regulating ribosomal proteins by binding to pseudoknot structures in the polycistronic mRNA; interacts with transcription complex and functions similar to protein NusA in antitermination YP_002470676.1 catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates. Dimerization of the alpha subunit is the first step in the sequential assembly of subunits to form the holoenzyme YP_002470677.1 is a component of the macrolide binding site in the peptidyl transferase center YP_002470678.1 with CbiNQ forms the ABC transporter for cobalt import; Mycoplasmas have two adjacent copies of this gene YP_002470679.1 with CbiNQ forms the ABC transporter for cobalt import; Clostridia have two adjacent copies of this gene YP_002470680.1 homology (Evalue<1e-4) to COG0619 [P] ABC-type cobalt transport system, permease component CbiQ and related transporters YP_002470681.1 mediates pseudouridylation (positions 38, 39, 40) at the tRNA anticodon region which contributes to the structural stability YP_002470682.1 in Escherichia coli this protein is one of the earliest assembly proteins in the large subunit YP_002470683.1 forms a direct contact with the tRNA during translation YP_002470684.1 homology (Evalue<1e-4) to COG1943 [L] Predicted transposase YP_002470685.1 homology (Evalue<1e-4) to COG1961 [L] Site-specific recombinases, DNA invertase Pin homologs YP_002470689.1 homology (Evalue<1e-4) to COG1387 [ER] Histidinol phosphatase and related hydrolases of the PHP family YP_002470690.1 homology (Evalue<1e-4) to COG0738 [G] Fucose permease YP_002470691.1 homology (Evalue<1e-4) to COG2207 [K] AraC-type DNA-binding domain-containing proteins YP_002470692.1 homology (Evalue<1e-4) to COG1683 [S] Uncharacterized ACR YP_002470693.1 homology (Evalue<1e-4) to COG0778 [C] Nitroreductase YP_002470694.1 homology (Evalue<1e-4) to COG1309 [K] Transcriptional regulator YP_002470702.1 homology (Evalue<1e-4) to COG0791 [M] Cell wall-associated hydrolases (invasion-associated proteins) YP_002470703.1 homology (Evalue<1e-4) to COG0433 [R] Predicted ATPase YP_002470706.1 homology (Evalue<1e-4) to COG2088 [M] Uncharacterized protein, involved in the regulation of septum location YP_002470708.1 homology (Evalue<1e-4) to COG3505 [N] Type IV secretory pathway, VirD4 components YP_002470712.1 homology (Evalue<1e-4) to COG1475 [K] Predicted transcriptional regulators YP_002470713.1 homology (Evalue<1e-4) to COG1961 [L] Site-specific recombinases, DNA invertase Pin homologs YP_002470716.1 homology (Evalue<1e-4) to COG0860 [M] N-acetylmuramoyl-L-alanine amidase YP_002470717.1 homology (Evalue<1e-4) to COG1725 [K] Predicted transcriptional regulators YP_002470719.1 Catalyzes the reversible hydration of fumaric acid to yield I-malic acid YP_002470720.1 homology (Evalue<1e-4) to COG1838 [C] Tartrate dehydratase beta subunit/Fumarate hydratase class I, C-terminal domain YP_002470721.1 homology (Evalue<1e-4) to COG3697 [HI] Phosphoribosyl-dephospho-CoA transferase (holo-ACP synthetase) YP_002470722.1 homology (Evalue<1e-4) to COG0457 [R] TPR-repeat-containing proteins YP_002470723.1 homology (Evalue<1e-4) to COG1080 [G] Phosphoenolpyruvate-protein kinase (PTS system EI component in bacteria) YP_002470725.1 homology (Evalue<1e-4) to COG0457 [R] TPR-repeat-containing proteins YP_002470726.1 homology (Evalue<1e-4) to COG0526 [OC] Thiol-disulfide isomerase and thioredoxins YP_002470727.1 homology (Evalue<1e-4) to COG0492 [O] Thioredoxin reductase YP_002470728.1 homology (Evalue<1e-4) to COG3773 [M] Cell wall hydrolyses involved in spore germination YP_002470729.1 homology (Evalue<1e-4) to COG1624 [S] Uncharacterized ACR YP_002470731.1 homology (Evalue<1e-4) to COG2509 [R] Uncharacterized FAD-dependent dehydrogenases YP_002470732.1 catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate YP_002470733.1 Catalyzes the first step in hexosamine metabolism, converting fructose-6P into glucosamine-6P using glutamine as a nitrogen source YP_002470734.1 homology (Evalue<1e-4) to COG0477 [GEPR] Permeases of the major facilitator superfamily YP_002470735.1 homology (Evalue<1e-4) to COG2153 [R] Predicted acyltransferases YP_002470737.1 homology (Evalue<1e-4) to COG1145 [C] Ferredoxin 2 YP_002470738.1 homology (Evalue<1e-4) to COG1396 [K] Predicted transcriptional regulators YP_002470739.1 homology (Evalue<1e-4) to COG1180 [O] Pyruvate-formate lyase-activating enzyme YP_002470740.1 homology (Evalue<1e-4) to COG1882 [C] Pyruvate-formate lyase YP_002470741.1 homology (Evalue<1e-4) to COG3314 [S] Uncharacterized BCR YP_002470743.1 homology (Evalue<1e-4) to COG0345 [E] Pyrroline-5-carboxylate reductase YP_002470744.1 homology (Evalue<1e-4) to COG3123 [S] Uncharacterized BCR YP_002470745.1 homology (Evalue<1e-4) to COG1720 [S] Uncharacterized ACR YP_002470746.1 homology (Evalue<1e-4) to COG1691 [R] NCAIR mutase (PurE)-related proteins YP_002470747.1 homology (Evalue<1e-4) to COG1453 [R] Predicted oxidoreductases of the aldo/keto reductase family YP_002470748.1 homology (Evalue<1e-4) to COG0789 [K] Predicted transcriptional regulators YP_002470749.1 homology (Evalue<1e-4) to COG1641 [S] Uncharacterized ACR YP_002470750.1 homology (Evalue<1e-4) to COG0239 [D] Integral membrane protein possibly involved in chromosome condensation YP_002470751.1 may be involved in chromosome condensation; overexpression in Escherichia coli protects against decondensation by camphor; overexpressing the protein results in an increase in supercoiling YP_002470752.1 homology (Evalue<1e-4) to COG1993 [S] Uncharacterized ACR YP_002470756.1 homology (Evalue<1e-4) to COG1846 [K] Transcriptional regulators YP_002470757.1 homology (Evalue<1e-4) to COG0735 [P] Fe2+/Zn2+ uptake regulation proteins YP_002470758.1 homology (Evalue<1e-4) to COG0778 [C] Nitroreductase YP_002470759.1 this stereospecific enzymes reduces the S isomer of methionine sulfoxide while MsrB reduces the R form; provides protection against oxidative stress YP_002470760.1 homology (Evalue<1e-4) to COG1902 [C] NADH:flavin oxidoreductases, Old Yellow Enzyme family YP_002470761.1 homology (Evalue<1e-4) to COG1680 [M] Beta-lactamase class C and other penicillin binding proteins YP_002470762.1 homology (Evalue<1e-4) to COG1917 [S] Uncharacterized ACR, double-stranded beta-helix domain YP_002470763.1 homology (Evalue<1e-4) to COG2206 [T] HD-GYP domain YP_002470765.1 homology (Evalue<1e-4) to COG1396 [K] Predicted transcriptional regulators YP_002470766.1 homology (Evalue<1e-4) to COG3384 [S] Uncharacterized ACR YP_002470769.1 DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates YP_002470771.1 homology (Evalue<1e-4) to COG2378 [K] Predicted transcriptional regulator YP_002470773.1 homology (Evalue<1e-4) to COG0789 [K] Predicted transcriptional regulators YP_002470774.1 homology (Evalue<1e-4) to COG3695 [L] Predicted methylated DNA-protein cysteine methyltransferase YP_002470775.1 homology (Evalue<1e-4) to COG0242 [J] N-formylmethionyl-tRNA deformylase YP_002470776.1 homology (Evalue<1e-4) to COG0745 [TK] Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain YP_002470777.1 homology (Evalue<1e-4) to COG0642 [T] Signal transduction histidine kinase YP_002470778.1 homology (Evalue<1e-4) to COG3634 [O] Alkyl hydroperoxide reductase, large subunit YP_002470779.1 homology (Evalue<1e-4) to COG0450 [O] Peroxiredoxin YP_002470780.1 homology (Evalue<1e-4) to COG1136 [R] ABC-type transport systems, involved in lipoprotein release, ATPase components YP_002470781.1 homology (Evalue<1e-4) to COG0577 [R] ABC-type transport systems, involved in lipoprotein release, permease components YP_002470782.1 homology (Evalue<1e-4) to COG2207 [K] AraC-type DNA-binding domain-containing proteins YP_002470783.1 homology (Evalue<1e-4) to COG1132 [Q] ABC-type multidrug/protein/lipid transport system, ATPase component YP_002470784.1 homology (Evalue<1e-4) to COG1132 [Q] ABC-type multidrug/protein/lipid transport system, ATPase component YP_002470785.1 homology (Evalue<1e-4) to COG2710 [C] Nitrogenase molybdenum-iron protein, alpha and beta chains YP_002470787.1 homology (Evalue<1e-4) to COG2710 [C] Nitrogenase molybdenum-iron protein, alpha and beta chains YP_002470788.1 homology (Evalue<1e-4) to COG0518 [F] GMP synthase - Glutamine amidotransferase domain YP_002470789.1 homology (Evalue<1e-4) to COG3467 [R] Predicted flavin-nucleotide-binding protein YP_002470790.1 homology (Evalue<1e-4) to COG0535 [R] Predicted Fe-S oxidoreductases YP_002470791.1 homology (Evalue<1e-4) to COG0535 [R] Predicted Fe-S oxidoreductases YP_002470792.1 homology (Evalue<1e-4) to COG1522 [K] Transcriptional regulators YP_002470793.1 homology (Evalue<1e-4) to COG1522 [K] Transcriptional regulators YP_002470794.1 homology (Evalue<1e-4) to COG2388 [R] Predicted acetyltransferase YP_002470795.1 homology (Evalue<1e-4) to COG3481 [R] Predicted HD-superfamily hydrolase YP_002470797.1 homology (Evalue<1e-4) to COG1994 [R] Zn-dependent proteases YP_002470798.1 homology (Evalue<1e-4) to COG1277 [R] ABC-type transport system involved in multi-copper enzyme maturation, permease component YP_002470799.1 homology (Evalue<1e-4) to COG1131 [Q] ABC-type multidrug transport system, ATPase component YP_002470800.1 homology (Evalue<1e-4) to COG1725 [K] Predicted transcriptional regulators YP_002470801.1 homology (Evalue<1e-4) to COG0477 [GEPR] Permeases of the major facilitator superfamily YP_002470802.1 homology (Evalue<1e-4) to COG1846 [K] Transcriptional regulators YP_002470803.1 homology (Evalue<1e-4) to COG3279 [KT] Response regulator of the LytR/AlgR family YP_002470804.1 homology (Evalue<1e-4) to COG3290 [T] Signal transduction histidine kinase regulating citrate/malate metabolism YP_002470807.1 homology (Evalue<1e-4) to COG0577 [R] ABC-type transport systems, involved in lipoprotein release, permease components YP_002470808.1 homology (Evalue<1e-4) to COG1136 [R] ABC-type transport systems, involved in lipoprotein release, ATPase components YP_002470809.1 homology (Evalue<1e-4) to COG1696 [M] Predicted membrane protein involved in D-alanine export YP_002470814.1 homology (Evalue<1e-4) to COG3682 [K] Predicted transcriptional regulator YP_002470816.1 homology (Evalue<1e-4) to COG1595 [K] DNA-directed RNA polymerase specialized sigma subunits, sigma24 homologs YP_002470819.1 homology (Evalue<1e-4) to COG3682 [K] Predicted transcriptional regulator YP_002470822.1 homology (Evalue<1e-4) to COG2247 [M] cell wall-binding domain YP_002470823.1 homology (Evalue<1e-4) to COG2200 [T] EAL domain YP_002470824.1 homology (Evalue<1e-4) to COG1878 [R] Uncharacterized ACR, predicted metal-dependent hydrolases YP_002470825.1 homology (Evalue<1e-4) to COG1846 [K] Transcriptional regulators YP_002470826.1 homology (Evalue<1e-4) to COG0840 [N] Methyl-accepting chemotaxis protein YP_002470827.1 homology (Evalue<1e-4) to COG0582 [L] Integrase YP_002470828.1 homology (Evalue<1e-4) to COG3723 [L] Recombinational DNA repair protein (RecE pathway) YP_002470830.1 homology (Evalue<1e-4) to COG2032 [P] Cu/Zn superoxide dismutase YP_002470832.1 homology (Evalue<1e-4) to COG1775 [E] Benzoyl-CoA reductase/2-hydroxyglutaryl-CoA dehydratase subunit, BcrC/BadD/HgdB YP_002470833.1 homology (Evalue<1e-4) to COG1924 [I] Activator of 2-hydroxyglutaryl-CoA dehydratase (HSP70-class ATPase domain) YP_002470834.1 homology (Evalue<1e-4) to COG0603 [R] Predicted ATPase (PP-loop superfamily), confers aluminum resistance YP_002470836.1 catalyzes the formation of 2-oxobutanoate from L-threonine YP_002470837.1 homology (Evalue<1e-4) to COG0489 [D] ATPases involved in chromosome partitioning YP_002470838.1 homology (Evalue<1e-4) to COG3411 [C] Ferredoxin YP_002470839.1 homology (Evalue<1e-4) to COG0840 [N] Methyl-accepting chemotaxis protein YP_002470840.1 homology (Evalue<1e-4) to COG0004 [P] Ammonia permeases YP_002470841.1 homology (Evalue<1e-4) to COG0347 [E] Nitrogen regulatory protein PII YP_002470842.1 homology (Evalue<1e-4) to COG0446 [R] Uncharacterized NAD(FAD)-dependent dehydrogenases YP_002470843.1 homology (Evalue<1e-4) to COG0640 [K] Predicted transcriptional regulators YP_002470844.1 homology (Evalue<1e-4) to COG0116 [L] Predicted N6-adenine-specific DNA methylases YP_002470845.1 homology (Evalue<1e-4) to COG0513 [LKJ ] Superfamily II DNA and RNA helicases YP_002470846.1 homology (Evalue<1e-4) to COG0111 [E] Phosphoglycerate dehydrogenase and related dehydrogenases YP_002470847.1 homology (Evalue<1e-4) to COG2207 [K] AraC-type DNA-binding domain-containing proteins YP_002470848.1 homology (Evalue<1e-4) to COG1301 [C] Na+/H+-dicarboxylate symporters YP_002470849.1 homology (Evalue<1e-4) to COG1167 [KE] Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain (MocR family) and their eukaryotic orthologs YP_002470850.1 catalyzes the formation of 10-formyltetrahydrofolate from formate and tetrahydrofolate YP_002470851.1 homology (Evalue<1e-4) to COG3404 [E] Methenyl tetrahydrofolate cyclohydrolase YP_002470852.1 homology (Evalue<1e-4) to COG0190 [H] 5,10-methylene-tetrahydrofolate dehydrogenase/Methenyl tetrahydrofolate cyclohydrolase YP_002470853.1 homology (Evalue<1e-4) to COG0446 [R] Uncharacterized NAD(FAD)-dependent dehydrogenases YP_002470856.1 in most organisms, only the N-terminal domain is present in a single polypeptide; in some archaea this domain is fused to a kinase domain; this gene is essential for growth in Escherichia coli and Bacillus subtilis; the secreted glycoprotease from Pasteurella haemolytica showed specificity for O-sialoglycosylated proteins; the Pyrococcus structure shows DNA-binding properties, iron-binding, ATP-binding, and AP endonuclease activity YP_002470857.1 biotin-containing enzyme that catalyzes a two step carboxylation of pyruvate to oxaloacetate YP_002470858.1 homology (Evalue<1e-4) to COG1752 [R] Predicted esterase of the alpha-beta hydrolase superfamily YP_002470859.1 homology (Evalue<1e-4) to COG1026 [R] Predicted Zn-dependent peptidases, insulinase-like YP_002470860.1 homology (Evalue<1e-4) to COG0011 [S] Uncharacterized ACR YP_002470861.1 homology (Evalue<1e-4) to COG0784 [T] CheY-like receiver domain YP_002470862.1 homology (Evalue<1e-4) to COG0488 [R] ATPase components of ABC transporters with duplicated ATPase domains YP_002470863.1 modulates transcription in response to the NADH/NAD(+) redox state YP_002470864.1 catalyzes the formation of crotonoyl-CoA from (3R)-3-hydroxybutanoyl-CoA YP_002470865.1 homology (Evalue<1e-4) to COG1960 [I] Acyl-CoA dehydrogenases YP_002470866.1 homology (Evalue<1e-4) to COG2086 [C] Electron transfer flavoprotein beta-subunit YP_002470867.1 homology (Evalue<1e-4) to COG2025 [C] Electron transfer flavoprotein alpha-subunit YP_002470868.1 homology (Evalue<1e-4) to COG1250 [I] 3-Hydroxyacyl-CoA dehydrogenase YP_002470869.1 homology (Evalue<1e-4) to COG0543 [HC] 2-polyprenylphenol hydroxylase and related flavodoxin oxidoreductases YP_002470870.1 function undetermined; similar to glutamate synthase beta subunit and related oxidoreductases which transfer electrons from NADPH to an acceptor protein or protein domain YP_002470871.1 homology (Evalue<1e-4) to COG0122 [L] 3-Methyladenine DNA glycosylase YP_002470872.1 homology (Evalue<1e-4) to COG0398 [S] Uncharacterized ACR YP_002470873.1 10 kDa chaperonin; Cpn10; GroES; forms homoheptameric ring; binds to one or both ends of the GroEL double barrel in the presence of adenine nucleotides capping it; folding of unfolded substrates initiates in a GroEL-substrate bound and capped by GroES; release of the folded substrate is dependent on ATP binding and hydrolysis in the trans ring YP_002470874.1 60 kDa chaperone family; promotes refolding of misfolded polypeptides especially under stressful conditions; forms two stacked rings of heptamers to form a barrel-shaped 14mer; ends can be capped by GroES; misfolded proteins enter the barrel where they are refolded when GroES binds; many bacteria have multiple copies of the groEL gene which are active under different environmental conditions; the B.japonicum protein in this cluster is expressed constitutively; in Rhodobacter, Corynebacterium and Rhizobium this protein is essential for growth YP_002470875.1 catalyzes the synthesis of xanthosine monophosphate by the NAD+ dependent oxidation of inosine monophosphate YP_002470876.1 contains glutamine-hydrolyzing domain and glutamine amidotransferase; GMP-binding domain; functions to produce GMP from XMP in the IMP pathway YP_002470877.1 homology (Evalue<1e-4) to COG0582 [L] Integrase YP_002470882.1 homology (Evalue<1e-4) to COG0419 [L] ATPase involved in DNA repair YP_002470894.1 homology (Evalue<1e-4) to COG3546 [P] Mn-containing catalase YP_002470895.1 homology (Evalue<1e-4) to COG0657 [I] Esterase/lipase YP_002470896.1 homology (Evalue<1e-4) to COG1476 [K] Predicted transcriptional regulators YP_002470897.1 homology (Evalue<1e-4) to COG2801 [L] transposase YP_002470898.1 homology (Evalue<1e-4) to COG2801 [L] transposase YP_002470900.1 homology (Evalue<1e-4) to COG3467 [R] Predicted flavin-nucleotide-binding protein YP_002470902.1 homology (Evalue<1e-4) to COG1234 [R] Metal-dependent hydrolases of the beta-lactamase superfamily III YP_002470907.1 homology (Evalue<1e-4) to COG0824 [R] Predicted thioesterase YP_002470908.1 homology (Evalue<1e-4) to COG1309 [K] Transcriptional regulator YP_002470909.1 homology (Evalue<1e-4) to COG1115 [E] Na+/alanine symporter YP_002470910.1 homology (Evalue<1e-4) to COG0475 [P] Kef-type K+ transport systems, membrane components YP_002470911.1 catalyzes the formation of pyruvate from D-cysteine YP_002470912.1 homology (Evalue<1e-4) to COG2733 [S] Uncharacterized membrane protein YP_002470913.1 homology (Evalue<1e-4) to COG2733 [S] Uncharacterized membrane protein YP_002470914.1 homology (Evalue<1e-4) to COG0443 [O] Molecular chaperone YP_002470915.1 homology (Evalue<1e-4) to COG0443 [O] Molecular chaperone YP_002470916.1 homology (Evalue<1e-4) to COG0443 [O] Molecular chaperone YP_002470917.1 homology (Evalue<1e-4) to COG0443 [O] Molecular chaperone YP_002470918.1 homology (Evalue<1e-4) to COG0419 [L] ATPase involved in DNA repair YP_002470919.1 homology (Evalue<1e-4) to COG2885 [M] Outer membrane protein and related peptidoglycan-associated (lipo)proteins YP_002470921.1 homology (Evalue<1e-4) to COG2247 [M] cell wall-binding domain YP_002470924.1 homology (Evalue<1e-4) to COG0378 [OK] Ni2+-binding GTPase involved in regulation of expression and maturation of urease and hydrogenase YP_002470925.1 homology (Evalue<1e-4) to COG1136 [R] ABC-type transport systems, involved in lipoprotein release, ATPase components YP_002470928.1 homology (Evalue<1e-4) to COG0031 [E] Cysteine synthase YP_002470929.1 homology (Evalue<1e-4) to COG2710 [C] Nitrogenase molybdenum-iron protein, alpha and beta chains YP_002470931.1 homology (Evalue<1e-4) to COG3279 [KT] Response regulator of the LytR/AlgR family YP_002470934.1 homology (Evalue<1e-4) to COG2267 [I] Lysophospholipase YP_002470936.1 homology (Evalue<1e-4) to COG0288 [P] Carbonic anhydrase YP_002470939.1 homology (Evalue<1e-4) to COG1376 [S] Uncharacterized BCR YP_002470940.1 involved in assembly of spore coat proteins such as GerQ by catalyzing epsilon-(gamma-glutamyl)lysine cross links YP_002470942.1 homology (Evalue<1e-4) to COG1633 [S] Uncharacterized ACR YP_002470943.1 homology (Evalue<1e-4) to COG0308 [E] Aminopeptidase N YP_002470944.1 homology (Evalue<1e-4) to COG3284 [Q] Transcriptional activator of acetoin/glycerol metabolism YP_002470945.1 homology (Evalue<1e-4) to COG1454 [C] Alcohol dehydrogenase IV YP_002470946.1 homology (Evalue<1e-4) to COG0477 [GEPR] Permeases of the major facilitator superfamily YP_002470947.1 homology (Evalue<1e-4) to COG0513 [LKJ ] Superfamily II DNA and RNA helicases YP_002470948.1 Converts isocitrate to alpha ketoglutarate YP_002470949.1 homology (Evalue<1e-4) to COG1878 [R] Uncharacterized ACR, predicted metal-dependent hydrolases YP_002470950.1 homology (Evalue<1e-4) to COG3655 [K] Predicted transcriptional regulator YP_002470951.1 homology (Evalue<1e-4) to COG0662 [G] Mannose-6-phosphate isomerase YP_002470952.1 homology (Evalue<1e-4) to COG1247 [M] Sortase and related acyltransferases YP_002470953.1 homology (Evalue<1e-4) to COG0789 [K] Predicted transcriptional regulators YP_002470954.1 homology (Evalue<1e-4) to COG3594 [G] Fucose 4-O-acetylase and related acetyltransferases YP_002470958.1 homology (Evalue<1e-4) to COG1193 [L] MutS-like ATPases involved in mismatch repair, family 1 YP_002470959.1 homology (Evalue<1e-4) to COG3328 [L] Predicted transposase YP_002470960.1 homology (Evalue<1e-4) to COG3328 [L] Predicted transposase YP_002470961.1 homology (Evalue<1e-4) to COG0550 [L] Topoisomerase IA YP_002470962.1 homology (Evalue<1e-4) to COG0745 [TK] Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain YP_002470963.1 homology (Evalue<1e-4) to COG0642 [T] Signal transduction histidine kinase YP_002470964.1 homology (Evalue<1e-4) to COG0451 [MG] Nucleoside-diphosphate-sugar epimerases YP_002470965.1 homology (Evalue<1e-4) to COG1063 [ER] Threonine dehydrogenase and related Zn-dependent dehydrogenases YP_002470966.1 homology (Evalue<1e-4) to COG0637 [R] Predicted phosphatase/phosphohexomutase YP_002470967.1 homology (Evalue<1e-4) to COG1733 [K] Predicted transcriptional regulators YP_002470968.1 homology (Evalue<1e-4) to COG2159 [R] Predicted metal-dependent hydrolase of the TIM-barrel fold YP_002470971.1 homology (Evalue<1e-4) to COG0206 [D] Cell division GTPase YP_002470972.1 homology (Evalue<1e-4) to COG0419 [L] ATPase involved in DNA repair YP_002470973.1 homology (Evalue<1e-4) to COG2050 [Q] Uncharacterized protein, possibly involved in aromatic compounds catabolism YP_002470974.1 homology (Evalue<1e-4) to COG2201 [NT] Chemotaxis response regulator containing a CheY-like receiver domain and a methylesterase domain YP_002470975.1 homology (Evalue<1e-4) to COG1352 [NT] Methylase of chemotaxis methyl-accepting proteins YP_002470977.1 homology (Evalue<1e-4) to COG2207 [K] AraC-type DNA-binding domain-containing proteins YP_002470978.1 homology (Evalue<1e-4) to COG1695 [K] Predicted transcriptional regulators YP_002470980.1 homology (Evalue<1e-4) to COG3344 [L] Retron-type reverse transcriptase YP_002470981.1 homology (Evalue<1e-4) to COG2020 [O] protein-S-isoprenylcysteine methyltransferase YP_002470985.1 homology (Evalue<1e-4) to COG3385 [L] Predicted transposase YP_002470986.1 homology (Evalue<1e-4) to COG0583 [K] Transcriptional regulator YP_002470987.1 homology (Evalue<1e-4) to COG1902 [C] NADH:flavin oxidoreductases, Old Yellow Enzyme family YP_002470988.1 homology (Evalue<1e-4) to COG2814 [G] Arabinose efflux permease YP_002470990.1 homology (Evalue<1e-4) to COG3666 [L] Transposase YP_002470991.1 homology (Evalue<1e-4) to COG3666 [L] Transposase YP_002470992.1 homology (Evalue<1e-4) to COG1906 [S] Uncharacterized ACR YP_002470994.1 homology (Evalue<1e-4) to COG0726 [G] Predicted xylanase/chitin deacetylase YP_002470996.1 catalyzes the formation of prolyl-tRNA(Pro) from proline and tRNA(Pro) YP_002470997.1 homology (Evalue<1e-4) to COG0465 [O] ATP-dependent Zn proteases YP_002470998.1 homology (Evalue<1e-4) to COG0210 [L] Superfamily I DNA and RNA helicases YP_002470999.1 catalyzes the formation of biotin from dethiobiotin and sulfur YP_002471000.1 homology (Evalue<1e-4) to COG0527 [E] Aspartokinases YP_002471001.1 homology (Evalue<1e-4) to COG0019 [E] Diaminopimelate decarboxylase YP_002471002.1 homology (Evalue<1e-4) to COG3459 [G] Cellobiose phosphorylase YP_002471003.1 catalyzes a two-step reaction, first charging a tryptophan molecule by linking its carboxyl group to the alpha-phosphate of ATP, followed by transfer of the aminoacyl-adenylate to its tRNA YP_002471004.1 homology (Evalue<1e-4) to COG0515 [T] Serine/threonine protein kinases YP_002471005.1 homology (Evalue<1e-4) to COG0535 [R] Predicted Fe-S oxidoreductases YP_002471006.1 homology (Evalue<1e-4) to COG1418 [R] Predicted HD superfamily hydrolase YP_002471007.1 homology (Evalue<1e-4) to COG2964 [S] Uncharacterized BCR YP_002471008.1 homology (Evalue<1e-4) to COG3681 [S] Uncharacterized ACR YP_002471009.1 homology (Evalue<1e-4) to COG2199 [T] GGDEF domain YP_002471011.1 homology (Evalue<1e-4) to COG1101 [EPGR] Various ABC transport systems, ATPase components YP_002471012.1 homology (Evalue<1e-4) to COG0559 [E] Branched-chain amino acid ABC-type transport system, permease components YP_002471013.1 homology (Evalue<1e-4) to COG2984 [S] Uncharacterized BCR YP_002471015.1 homology (Evalue<1e-4) to COG0500 [QR] SAM-dependent methyltransferases YP_002471016.1 homology (Evalue<1e-4) to COG0489 [D] ATPases involved in chromosome partitioning YP_002471017.1 homology (Evalue<1e-4) to COG1433 [S] Uncharacterized ACR YP_002471018.1 homology (Evalue<1e-4) to COG1149 [C] MinD superfamily P-loop ATPase containing an inserted ferredoxin domain YP_002471019.1 homology (Evalue<1e-4) to COG1149 [C] MinD superfamily P-loop ATPase containing an inserted ferredoxin domain YP_002471021.1 homology (Evalue<1e-4) to COG1433 [S] Uncharacterized ACR YP_002471022.1 homology (Evalue<1e-4) to COG0735 [P] Fe2+/Zn2+ uptake regulation proteins YP_002471023.1 homology (Evalue<1e-4) to COG1342 [R] Predicted DNA-binding proteins YP_002471024.1 homology (Evalue<1e-4) to COG0822 [C] NifU homologs involved in Fe-S cluster formation YP_002471025.1 homology (Evalue<1e-4) to COG1960 [I] Acyl-CoA dehydrogenases YP_002471026.1 homology (Evalue<1e-4) to COG1342 [R] Predicted DNA-binding proteins YP_002471029.1 catalyzes the formation of tetrahydrofolate and 2-dehydropantoate from 5,10-methylenetetrahydrofolate and 3-methyl-2-oxobutanoate YP_002471030.1 catalyzes the formation of (R)-pantothenate from pantoate and beta-alanine YP_002471031.1 homology (Evalue<1e-4) to COG0561 [R] Predicted hydrolases of the HAD superfamily YP_002471032.1 homology (Evalue<1e-4) to COG2719 [S] Uncharacterized BCR YP_002471033.1 homology (Evalue<1e-4) to COG2718 [S] Uncharacterized BCR YP_002471034.1 homology (Evalue<1e-4) to COG2766 [T] Ser protein kinase YP_002471035.1 homology (Evalue<1e-4) to COG1846 [K] Transcriptional regulators YP_002471036.1 homology (Evalue<1e-4) to COG0477 [GEPR] Permeases of the major facilitator superfamily YP_002471037.1 homology (Evalue<1e-4) to COG1566 [Q] Multidrug resistance efflux pump YP_002471038.1 homology (Evalue<1e-4) to COG0845 [Q] Membrane-fusion protein YP_002471039.1 homology (Evalue<1e-4) to COG1113 [E] Gamma-aminobutyrate permease and related permeases YP_002471040.1 catalyzes production of carbamoyl phosphate from bicarbonate and glutamine in pyrimidine and arginine biosynthesis pathways; forms an octamer composed of four CarAB dimers YP_002471041.1 four CarB-CarA dimers form the carbamoyl phosphate synthetase holoenzyme that catalyzes the production of carbamoyl phosphate; CarB is responsible for the amidotransferase activity YP_002471042.1 homology (Evalue<1e-4) to COG1473 [R] Metal-dependent amidase/aminoacylase/carboxypeptidase YP_002471043.1 homology (Evalue<1e-4) to COG0642 [T] Signal transduction histidine kinase YP_002471044.1 homology (Evalue<1e-4) to COG0745 [TK] Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain YP_002471045.1 homology (Evalue<1e-4) to COG0463 [M] Glycosyltransferases involved in cell wall biogenesis YP_002471046.1 homology (Evalue<1e-4) to COG2246 [S] Uncharacterized membrane protein YP_002471047.1 homology (Evalue<1e-4) to COG1807 [M] 4-amino-4-deoxy-L-arabinose transferase and related glycosyltransferases of PMT family YP_002471048.1 catalyzes the formation of glutamate-1-semialdehyde from glutamyl-tRNA(Glu) and NADPH; the second step of the pathway is catalyzed by glutamate-1-semialdehyde aminomutase which results in the formation of 5-aminolevulinic acid; functions in porphyrin (tetrapyrroles) biosynthesis; the crystal structure showed a C-terminal dimerization domain that appears to be absent in Chlamydial proteins YP_002471049.1 Converts (S)-4-amino-5-oxopentanoate to 5-aminolevulinate during the porphyrin biosynthesis pathway YP_002471050.1 homology (Evalue<1e-4) to COG1522 [K] Transcriptional regulators YP_002471051.1 homology (Evalue<1e-4) to COG0686 [E] Alanine dehydrogenase YP_002471052.1 homology (Evalue<1e-4) to COG3666 [L] Transposase YP_002471053.1 homology (Evalue<1e-4) to COG1807 [M] 4-amino-4-deoxy-L-arabinose transferase and related glycosyltransferases of PMT family YP_002471054.1 homology (Evalue<1e-4) to COG1307 [S] Uncharacterized BCR YP_002471055.1 homology (Evalue<1e-4) to COG1135 [R] Uncharacterized ABC-type transport system ATPase component YP_002471056.1 homology (Evalue<1e-4) to COG2011 [R] Permease component of an uncharacterized ABC transporter YP_002471057.1 homology (Evalue<1e-4) to COG3773 [M] Cell wall hydrolyses involved in spore germination YP_002471058.1 homology (Evalue<1e-4) to COG1852 [S] Uncharacterized ArCR YP_002471059.1 has 3'-5' exonuclease, 5'-3' exonuclease and 5'-3'polymerase activities, primarily functions to fill gaps during DNA replication and repair YP_002471060.1 catalyzes the phosphorylation of the 3'-hydroxyl group of dephosphocoenzyme A to form coenzyme A; involved in coenzyme A biosynthesis YP_002471061.1 homology (Evalue<1e-4) to COG0741 [M] Soluble lytic murein transglycosylase and related regulatory proteins (some contain LysM/invasin domains) YP_002471063.1 homology (Evalue<1e-4) to COG1028 [QR] Dehydrogenases with different specificities (related to short-chain alcohol dehydrogenases) YP_002471064.1 homology (Evalue<1e-4) to COG3546 [P] Mn-containing catalase YP_002471073.1 homology (Evalue<1e-4) to COG0642 [T] Signal transduction histidine kinase YP_002471074.1 homology (Evalue<1e-4) to COG0642 [T] Signal transduction histidine kinase YP_002471075.1 homology (Evalue<1e-4) to COG0745 [TK] Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain YP_002471078.1 homology (Evalue<1e-4) to COG0697 [GER] Permeases of the drug/metabolite transporter (DMT) superfamily YP_002471079.1 homology (Evalue<1e-4) to COG2195 [E] Di- and tripeptidases YP_002471081.1 homology (Evalue<1e-4) to COG0730 [R] Predicted permeases YP_002471083.1 homology (Evalue<1e-4) to COG0520 [E] Selenocysteine lyase YP_002471084.1 homology (Evalue<1e-4) to COG2376 [G] Dihydroxyacetone kinase YP_002471085.1 homology (Evalue<1e-4) to COG3412 [S] Uncharacterized BCR YP_002471086.1 catalyzes the formation of oxalozcetate and L-glutamate from L-aspartate and 2-oxoglutarate YP_002471087.1 homology (Evalue<1e-4) to COG1760 [E] L-serine deaminase YP_002471088.1 homology (Evalue<1e-4) to COG1760 [E] L-serine deaminase YP_002471089.1 homology (Evalue<1e-4) to COG1278 [K] Cold shock proteins YP_002471090.1 homology (Evalue<1e-4) to COG0477 [GEPR] Permeases of the major facilitator superfamily YP_002471091.1 catalyzes the formation of L-threonine from O-phospho-L-homoserine YP_002471092.1 homology (Evalue<1e-4) to COG3706 [T] Response regulator containing a CheY-like receiver domain and a GGDEF domain YP_002471093.1 homology (Evalue<1e-4) to COG1074 [L] ATP-dependent exoDNAse (exonuclease V) beta subunit (contains helicase and exonuclease domains) YP_002471094.1 homology (Evalue<1e-4) to COG0765 [E] ABC-type amino acid transport system, permease component YP_002471095.1 homology (Evalue<1e-4) to COG0834 [E] ABC-type amino acid transport system, periplasmic component YP_002471096.1 homology (Evalue<1e-4) to COG1026 [R] Predicted Zn-dependent peptidases, insulinase-like YP_002471097.1 homology (Evalue<1e-4) to COG0633 [C] Ferredoxin YP_002471099.1 homology (Evalue<1e-4) to COG1404 [O] Subtilisin-like serine proteases YP_002471100.1 catalyzes the formation of porphobilinogen from 5-aminolevulinate YP_002471101.1 homology (Evalue<1e-4) to COG0079 [E] Histidinol-phosphate aminotransferase/Tyrosine aminotransferase YP_002471102.1 homology (Evalue<1e-4) to COG2109 [H] ATP:corrinoid adenosyltransferase YP_002471103.1 catalyzes the formation of cobalt-precorrin 4 from cobalt-precorrin 3 YP_002471104.1 homology (Evalue<1e-4) to COG1577 [I] Mevalonate kinase YP_002471105.1 transformation of porphobilinogen to hydroxymethylbilane in porphyrin biosynthesis YP_002471106.1 homology (Evalue<1e-4) to COG0007 [H] Uroporphyrinogen-III methylase YP_002471108.1 catalyzes amidations at positions B, D, E, and G on adenosylcobyrinic A,C-diamide. NH(2) groups are provided by glutamine, and one molecule of ATP is hydrogenolyzed for each amidation YP_002471109.1 responsible for the amidation of carboxylic groups at position A and C of cobyrinic acid or hydrogenobrynic acid YP_002471110.1 catalyzes the interconversion of precorrin-8X and cobyrinic acid YP_002471111.1 Catalyzes the methylation of C-1 in cobalt-precorrin-5 and the subsequent extrusion of acetic acid from the resulting intermediate to form cobalt-precorrin-6A YP_002471112.1 homology (Evalue<1e-4) to COG2241 [H] Precorrin-6B methylase 1 YP_002471113.1 homology (Evalue<1e-4) to COG2242 [H] Precorrin-6B methylase 2 YP_002471114.1 catalyzes the formation of precorrin-3A from precorrin-2 YP_002471115.1 homology (Evalue<1e-4) to COG2875 [H] Precorrin-4 methylase YP_002471116.1 CobK/CbiJ; there are 2 pathways for cobalamin (vitamin B12) production, one aerobic (ex. P. denitrificans), the other anaerobic (ex. S. typhimurium); the CobK/CbiJ perform similar reactions in both; the anaerobic pathway includes the use of a chelated cobalt ion in order for ring contraction to occur; CobK thus converts precorrin 6 into dihydro-precorrin 6 while CbiJ converts cobalt-precorrin 6 into cobalt-deihydro-precorrin 6 YP_002471117.1 homology (Evalue<1e-4) to COG1010 [H] Precorrin-3B methylase YP_002471118.1 catalyzes ATP-dependent phosphorylation of adenosylcobinamide to form adenosylcobinamide phosphate and the addition of guanosine monophosphate to adenosylcobinamide phosphate to form adenosylcobinamide-GDP YP_002471119.1 homology (Evalue<1e-4) to COG0406 [G] Fructose-2,6-bisphosphatase YP_002471121.1 homology (Evalue<1e-4) to COG1733 [K] Predicted transcriptional regulators YP_002471122.1 homology (Evalue<1e-4) to COG0840 [N] Methyl-accepting chemotaxis protein YP_002471123.1 homology (Evalue<1e-4) to COG1454 [C] Alcohol dehydrogenase IV YP_002471124.1 homology (Evalue<1e-4) to COG0624 [E] Acetylornithine deacetylase/Succinyl-diaminopimelate desuccinylase and related deacylases YP_002471125.1 homology (Evalue<1e-4) to COG0531 [E] Amino acid transporters YP_002471126.1 homology (Evalue<1e-4) to COG1285 [S] Uncharacterized membrane protein YP_002471127.1 homology (Evalue<1e-4) to COG0716 [C] Flavodoxins YP_002471129.1 homology (Evalue<1e-4) to COG1902 [C] NADH:flavin oxidoreductases, Old Yellow Enzyme family YP_002471130.1 homology (Evalue<1e-4) to COG1266 [R] Predicted metal-dependent membrane protease YP_002471132.1 homology (Evalue<1e-4) to COG1902 [C] NADH:flavin oxidoreductases, Old Yellow Enzyme family YP_002471134.1 homology (Evalue<1e-4) to COG0379 [H] Quinolinate synthase YP_002471135.1 homology (Evalue<1e-4) to COG0029 [H] Aspartate oxidase YP_002471136.1 homology (Evalue<1e-4) to COG0157 [H] Nicotinate-nucleotide pyrophosphorylase YP_002471137.1 homology (Evalue<1e-4) to COG2206 [T] HD-GYP domain YP_002471138.1 homology (Evalue<1e-4) to COG0480 [J] Translation elongation and release factors (GTPases) YP_002471140.1 homology (Evalue<1e-4) to COG0671 [I] Membrane-associated phospholipid phosphatase YP_002471143.1 homology (Evalue<1e-4) to COG2865 [K] Predicted transcriptional regulator containing an HTH domain and an uncharacterized domain shared with the mammalian protein Schlafen YP_002471145.1 catalyzes the formation of tyrosyl-tRNA(Tyr) from tyrosine and tRNA(Tyr) YP_002471146.1 homology (Evalue<1e-4) to COG0456 [R] Acetyltransferases YP_002471147.1 homology (Evalue<1e-4) to COG1214 [O] Inactive homologs of metal-dependent proteases, molecular chaperones YP_002471148.1 homology (Evalue<1e-4) to COG0802 [R] Predicted ATPase or kinase YP_002471149.1 homology (Evalue<1e-4) to COG2206 [T] HD-GYP domain YP_002471150.1 homology (Evalue<1e-4) to COG0803 [P] ABC-type Mn/Zn transport system, periplasmic Mn/Zn-binding (lipo)protein (surface adhesin A) YP_002471151.1 homology (Evalue<1e-4) to COG0596 [R] Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) YP_002471152.1 homology (Evalue<1e-4) to COG0069 [E] Glutamate synthase domain 2 YP_002471153.1 homology (Evalue<1e-4) to COG0697 [GER] Permeases of the drug/metabolite transporter (DMT) superfamily YP_002471154.1 homology (Evalue<1e-4) to COG1834 [E] N-Dimethylarginine dimethylaminohydrolase YP_002471156.1 homology (Evalue<1e-4) to COG1053 [C] Succinate dehydrogenase/fumarate reductase, flavoprotein subunits YP_002471157.1 homology (Evalue<1e-4) to COG0479 [C] Succinate dehydrogenase/fumarate reductase Fe-S protein YP_002471158.1 homology (Evalue<1e-4) to COG2848 [S] Uncharacterized ACR YP_002471159.1 homology (Evalue<1e-4) to COG3830 [T] ACT domain-containing protein YP_002471160.1 homology (Evalue<1e-4) to COG1125 [E] ABC-type proline/glycine betaine transport systems, ATPase components YP_002471161.1 homology (Evalue<1e-4) to COG1174 [E] ABC-type proline/glycine betaine transport systems, permease component YP_002471162.1 homology (Evalue<1e-4) to COG2113 [E] ABC-type proline/glycine betaine transport systems, periplasmic components YP_002471163.1 Catalyzes the first of the two reduction steps in the elongation cycle of fatty acid synthesis YP_002471164.1 homology (Evalue<1e-4) to COG0745 [TK] Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain YP_002471165.1 homology (Evalue<1e-4) to COG0860 [M] N-acetylmuramoyl-L-alanine amidase YP_002471166.1 catalyzes the formation of 3-deoxy-D-arabino-hept-2-ulosonate 7-phosphate from phosphoenolpyruvate and D-erythrose 4-phosphate YP_002471167.1 homology (Evalue<1e-4) to COG0287 [E] Prephenate dehydrogenase YP_002471168.1 catalyzes the formation of 3-dehydroquinate from 3-deoxy-arabino-heptulonate 7-phosphate; functions in aromatic amino acid biosynthesis YP_002471169.1 catalyzes the formation of 5-O-(1-carboxyvinyl)-3-phosphoshikimate from phosphoenolpyruvate and 3-phosphoshikimate in tryptophan biosynthesis YP_002471170.1 catalyzes the formation of chorismate from 5-O-(1-carboxyvinyl)-3-phosphoshikimate in aromatic amino acid biosynthesis YP_002471171.1 homology (Evalue<1e-4) to COG0077 [E] Prephenate dehydratase YP_002471172.1 homology (Evalue<1e-4) to COG0169 [E] Shikimate 5-dehydrogenase YP_002471173.1 homology (Evalue<1e-4) to COG0703 [E] Shikimate kinase YP_002471175.1 homology (Evalue<1e-4) to COG3034 [S] Uncharacterized BCR YP_002471176.1 homology (Evalue<1e-4) to COG3391 [S] Uncharacterized ACR YP_002471177.1 homology (Evalue<1e-4) to COG1937 [S] Uncharacterized BCR YP_002471178.1 homology (Evalue<1e-4) to COG2217 [P] Cation transport ATPases YP_002471179.1 homology (Evalue<1e-4) to COG2608 [P] Copper chaperone YP_002471180.1 homology (Evalue<1e-4) to COG1109 [G] Phosphomannomutase YP_002471182.1 homology (Evalue<1e-4) to COG1502 [I] Phosphatidylserine/phosphatidylglycerophosphate/ cardiolipin synthases and related enzymes YP_002471184.1 homology (Evalue<1e-4) to COG0517 [R] CBS domains YP_002471188.1 homology (Evalue<1e-4) to COG3601 [S] Uncharacterized membrane protein YP_002471189.1 homology (Evalue<1e-4) to COG3191 [EQ] L-aminopeptidase/D-esterase YP_002471190.1 homology (Evalue<1e-4) to COG0539 [J] Ribosomal protein S1 YP_002471191.1 homology (Evalue<1e-4) to COG2200 [T] EAL domain YP_002471193.1 homology (Evalue<1e-4) to COG1309 [K] Transcriptional regulator YP_002471194.1 homology (Evalue<1e-4) to COG1132 [Q] ABC-type multidrug/protein/lipid transport system, ATPase component YP_002471195.1 homology (Evalue<1e-4) to COG1132 [Q] ABC-type multidrug/protein/lipid transport system, ATPase component YP_002471196.1 homology (Evalue<1e-4) to COG0726 [G] Predicted xylanase/chitin deacetylase YP_002471197.1 homology (Evalue<1e-4) to COG1104 [E] Cysteine sulfinate desulfinase/cysteine desulfurase and related enzymes YP_002471198.1 Required for the synthesis of the thiazole moiety YP_002471199.1 homology (Evalue<1e-4) to COG0265 [O] Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain YP_002471202.1 homology (Evalue<1e-4) to COG1584 [R] Predicted membrane protein YP_002471203.1 homology (Evalue<1e-4) to COG1135 [R] Uncharacterized ABC-type transport system ATPase component YP_002471204.1 homology (Evalue<1e-4) to COG2011 [R] Permease component of an uncharacterized ABC transporter YP_002471205.1 homology (Evalue<1e-4) to COG1464 [R] ABC-type uncharacterized transport systems, periplasmic component YP_002471206.1 homology (Evalue<1e-4) to COG2710 [C] Nitrogenase molybdenum-iron protein, alpha and beta chains YP_002471207.1 homology (Evalue<1e-4) to COG2710 [C] Nitrogenase molybdenum-iron protein, alpha and beta chains YP_002471209.1 homology (Evalue<1e-4) to COG0396 [R] Iron-regulated ABC transporter ATPase subunit SufC YP_002471210.1 homology (Evalue<1e-4) to COG0719 [R] Predicted membrane components of an uncharacterized iron-regulated ABC-type transporter SufB YP_002471211.1 homology (Evalue<1e-4) to COG0719 [R] Predicted membrane components of an uncharacterized iron-regulated ABC-type transporter SufB YP_002471212.1 homology (Evalue<1e-4) to COG0520 [E] Selenocysteine lyase YP_002471213.1 homology (Evalue<1e-4) to COG0822 [C] NifU homologs involved in Fe-S cluster formation YP_002471214.1 catalyzes the formation of inosine from adenosine YP_002471216.1 homology (Evalue<1e-4) to COG1894 [C] NADH:ubiquinone oxidoreductase, NADH-binding (51 kD) subunit YP_002471217.1 homology (Evalue<1e-4) to COG3383 [R] Uncharacterized anaerobic dehydrogenase YP_002471218.1 homology (Evalue<1e-4) to COG1142 [C] Fe-S-cluster-containing hydrogenase components 2 YP_002471219.1 homology (Evalue<1e-4) to COG1034 [C] NADH dehydrogenase/NADH:ubiquinone oxidoreductase 75 kD subunit (chain G) YP_002471223.1 homology (Evalue<1e-4) to COG0532 [J] Translation initiation factor 2 (GTPase) YP_002471225.1 homology (Evalue<1e-4) to COG0443 [O] Molecular chaperone YP_002471226.1 homology (Evalue<1e-4) to COG0452 [H] Phosphopantothenoylcysteine synthetase/decarboxylase YP_002471228.1 homology (Evalue<1e-4) to COG1726 [C] Na+-transporting NADH:ubiquinone oxidoreductase alpha subunit YP_002471230.1 homology (Evalue<1e-4) to COG1726 [C] Na+-transporting NADH:ubiquinone oxidoreductase alpha subunit YP_002471232.1 homology (Evalue<1e-4) to COG1726 [C] Na+-transporting NADH:ubiquinone oxidoreductase alpha subunit YP_002471234.1 homology (Evalue<1e-4) to COG1726 [C] Na+-transporting NADH:ubiquinone oxidoreductase alpha subunit YP_002471237.1 homology (Evalue<1e-4) to COG0460 [E] Homoserine dehydrogenase YP_002471238.1 catalyzes the formation of O-phospho-L-homoserine from L-homoserine in threonine biosynthesis from asparate YP_002471242.1 Maf; overexpression in Bacillus subtilis inhibits septation in the dividing cell YP_002471243.1 Involved in DNA double-strand break repair and recombination. Promotes the annealing of complementary single-stranded DNA and by simulation of RAD51 recombinase YP_002471244.1 functions in MreBCD complex in some organisms YP_002471245.1 in some organisms this protein is a transmembrane protein while in others it is periplasmic; involved in some organisms with other components of the MreBCD complex and with penicillin binding proteins in the periplasm or cell wall YP_002471246.1 homology (Evalue<1e-4) to COG2891 [M] Rod shape-determining protein YP_002471247.1 homology (Evalue<1e-4) to COG0768 [M] Cell division protein FtsI/penicillin-binding protein 2 YP_002471248.1 blocks the formation of polar Z-ring septums YP_002471249.1 homology (Evalue<1e-4) to COG2894 [D] Septum formation inhibitor-activating ATPase YP_002471250.1 homology (Evalue<1e-4) to COG0851 [D] Septum formation topological specificity factor YP_002471251.1 homology (Evalue<1e-4) to COG0772 [D] Bacterial cell division membrane protein YP_002471253.1 homology (Evalue<1e-4) to COG1994 [R] Zn-dependent proteases YP_002471254.1 homology (Evalue<1e-4) to COG1032 [C] Fe-S oxidoreductases family 2 YP_002471255.1 homology (Evalue<1e-4) to COG1032 [C] Fe-S oxidoreductases family 2 YP_002471256.1 homology (Evalue<1e-4) to COG1530 [J] Ribonucleases G and E YP_002471257.1 homology (Evalue<1e-4) to COG0261 [J] Ribosomal protein L21 YP_002471258.1 homology (Evalue<1e-4) to COG2868 [J] Predicted ribosomal protein YP_002471259.1 involved in the peptidyltransferase reaction during translation YP_002471260.1 essential GTPase; exhibits high exchange rate for GTP/GDP; associates with 50S ribosomal subunit; involved in regulation of chromosomal replication YP_002471261.1 transfers an adenyl group from ATP to NaMN to form nicotinic acid adenine dinucleotide (NaAD) which is then converted to the ubiquitous compound NAD by NAD synthetase; essential enzyme in bacteria YP_002471262.1 homology (Evalue<1e-4) to COG1713 [H] Predicted HD superfamily hydrolase involved in NAD metabolism YP_002471263.1 homology (Evalue<1e-4) to COG0251 [J] translation initiation inhibitor YP_002471264.1 homology (Evalue<1e-4) to COG0564 [J] Pseudouridylate synthases, 23S RNA-specific YP_002471265.1 homology (Evalue<1e-4) to COG1686 [M] D-alanyl-D-alanine carboxypeptidase YP_002471266.1 homology (Evalue<1e-4) to COG1555 [L] DNA uptake protein and related DNA-binding proteins YP_002471267.1 catalyzes the formation of oxalozcetate and L-glutamate from L-aspartate and 2-oxoglutarate YP_002471268.1 homology (Evalue<1e-4) to COG0679 [R] Predicted permeases YP_002471269.1 homology (Evalue<1e-4) to COG0474 [P] Cation transport ATPases YP_002471270.1 homology (Evalue<1e-4) to COG0658 [R] Predicted multitransmembrane, metal-binding protein YP_002471271.1 required for the assembly and function of the DNAX complex which is required for the assembly of the beta subunit onto primed DNA YP_002471272.1 binds directly to the 16S rRNA and is involved in post-translational inhibition of arginine and ornithine decarboxylase YP_002471273.1 Initiates the rapid degradation of small, acid-soluble proteins during spore germination YP_002471276.1 binds to the ribosome on the universally-conserved alpha-sarcin loop YP_002471277.1 catalyzes the oxygen-independent formation of protoporphyrinogen-IX from coproporphyrinogen-III YP_002471278.1 Negative regulator of class I heat shock genes (grpE-dnaK-dnaJ and groELS operons). Prevents heat-shock induction of these operons YP_002471279.1 with DnaK and DnaJ acts in response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins; may act as a thermosensor YP_002471280.1 heat shock protein 70; assists in folding of nascent polypeptide chains; refolding of misfolded proteins; utilizes ATPase activity to help fold; co-chaperones are DnaJ and GrpE; multiple copies in some bacteria YP_002471281.1 chaperone Hsp40; co-chaperone with DnaK; Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins and by disaggregating proteins, also in an autonomous, dnaK-independent fashion YP_002471282.1 methylates ribosomal protein L11 at multiple amino acid positions; mutations of these genes in Escherichia coli or Thermus thermophilus has no apparent phenotype YP_002471283.1 in Escherichia coli RsmE methylates the N3 position of the U1498 base in 16S rRNA; cells lacking this function can grow, but are outcompeted by wild-type; SAM-dependent m(3)U1498 methyltransferase YP_002471284.1 homology (Evalue<1e-4) to COG0621 [J] 2-methylthioadenine synthetase YP_002471285.1 homology (Evalue<1e-4) to COG0537 [FGR] Diadenosine tetraphosphate (Ap4A) hydrolase and other HIT family hydrolases YP_002471286.1 a small basic protein that is one of the last in the subunit assembly; omission does not prevent assembly but the subunit is inactive; binds central domain of 16S rRNA YP_002471287.1 homology (Evalue<1e-4) to COG1610 [S] Uncharacterized ACR YP_002471290.1 homology (Evalue<1e-4) to COG1480 [R] Predicted membrane-associated HD superfamily hydrolase YP_002471291.1 homology (Evalue<1e-4) to COG0319 [R] Predicted metal-dependent hydrolase YP_002471292.1 homology (Evalue<1e-4) to COG0818 [M] Diacylglycerol kinase YP_002471293.1 Reclaims exogenous and endogenous cytidine and 2'-deoxycytidine molecules for UMP synthesis YP_002471294.1 Era; Escherichia coli Ras-like protein; Bex; Bacillus Era-complementing segment; essential protein in Escherichia coli that is involved in many cellular processes; GTPase; binds the cell membrane through apparent C-terminal domain; mutants are arrested during the cell cycle; Streptococcus pneumoniae Era binds to RNA and Escherichia coli Era binds 16S rRNA and 30S ribosome YP_002471295.1 involved in DNA repair and RecFOR pathway recombination; RecFOR proteins displace ssDNA-binding protein and facilitate the production of RecA-coated ssDNA YP_002471297.1 homology (Evalue<1e-4) to COG0517 [R] CBS domains YP_002471298.1 catalyzes the formation of phosphoenolpyruvate from pyruvate YP_002471299.1 homology (Evalue<1e-4) to COG0111 [E] Phosphoglycerate dehydrogenase and related dehydrogenases YP_002471300.1 homology (Evalue<1e-4) to COG0583 [K] Transcriptional regulator YP_002471301.1 homology (Evalue<1e-4) to COG0263 [E] Glutamate 5-kinase YP_002471302.1 homology (Evalue<1e-4) to COG1902 [C] NADH:flavin oxidoreductases, Old Yellow Enzyme family YP_002471303.1 homology (Evalue<1e-4) to COG3382 [S] Uncharacterized ACR YP_002471304.1 homology (Evalue<1e-4) to COG0697 [GER] Permeases of the drug/metabolite transporter (DMT) superfamily YP_002471305.1 homology (Evalue<1e-4) to COG2207 [K] AraC-type DNA-binding domain-containing proteins YP_002471306.1 homology (Evalue<1e-4) to COG2963 [L] Transposase YP_002471307.1 homology (Evalue<1e-4) to COG1129 [G] ABC-type sugar (aldose) transport system, ATPase component YP_002471308.1 homology (Evalue<1e-4) to COG2227 [H] 2-polyprenyl-3-methyl-5-hydroxy-6-metoxy-1,4-benzoquinol methylase YP_002471309.1 homology (Evalue<1e-4) to COG1670 [J] Acetyltransferases, including N-acetylases of ribosomal proteins YP_002471310.1 homology (Evalue<1e-4) to COG0384 [R] Predicted epimerase, PhzC/PhzF homolog YP_002471311.1 homology (Evalue<1e-4) to COG2221 [C] Oxidoreductase related to nitrite reductase YP_002471312.1 homology (Evalue<1e-4) to COG0664 [T] cAMP-binding domains - Catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases YP_002471313.1 catalyzes the reduction of hydroxylamine to ammonia and water YP_002471314.1 homology (Evalue<1e-4) to COG1268 [R] Uncharacterized ACR YP_002471315.1 DTB synthetase; dethiobiotin synthase; involved in production of dethiobiotin from ATP and 7,8-diaminononanoate and carbon dioxide; contains magnesium YP_002471316.1 homology (Evalue<1e-4) to COG0161 [H] Adenosylmethionine-8-amino-7-oxononanoate aminotransferase YP_002471318.1 dGTPase family type 2 subfamily; presumably hydrolyzes dGTP to deoxyguanosine and triphosphate YP_002471319.1 synthesizes RNA primers at the replication forks YP_002471320.1 homology (Evalue<1e-4) to COG0568 [K] DNA-directed RNA polymerase sigma subunits (sigma70/sigma32) YP_002471322.1 homology (Evalue<1e-4) to COG2384 [R] Predicted SAM-dependent methyltransferase YP_002471323.1 homology (Evalue<1e-4) to COG0327 [S] Uncharacterized ACR YP_002471324.1 homology (Evalue<1e-4) to COG1579 [R] Zn-ribbon protein, possibly nucleic acid-binding YP_002471326.1 homology (Evalue<1e-4) to COG0370 [P] Fe2+ transport system YP_002471327.1 homology (Evalue<1e-4) to COG1918 [P] Fe2+ transport system YP_002471330.1 homology (Evalue<1e-4) to COG0294 [H] Dihydropteroate synthase and related enzymes YP_002471331.1 involved in the first step of tetrahydrofolate biosynthesis; catalyzes the formation of formate and 2-amino-4-hydroxy-6-(erythro-1,2, 3-trihydroxypropyl)dihydropteridine triphosphate from GTP and water; forms a homopolymer YP_002471333.1 homology (Evalue<1e-4) to COG0801 [H] 7,8-dihydro-6-hydroxymethylpterin-pyrophosphokinase YP_002471335.1 homology (Evalue<1e-4) to COG1277 [R] ABC-type transport system involved in multi-copper enzyme maturation, permease component YP_002471337.1 homology (Evalue<1e-4) to COG1131 [Q] ABC-type multidrug transport system, ATPase component YP_002471338.1 homology (Evalue<1e-4) to COG0642 [T] Signal transduction histidine kinase YP_002471339.1 homology (Evalue<1e-4) to COG0745 [TK] Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain YP_002471340.1 homology (Evalue<1e-4) to COG2333 [R] Predicted hydrolases of metallo-beta-lactamase fold YP_002471341.1 homology (Evalue<1e-4) to COG0204 [I] 1-acyl-sn-glycerol-3-phosphate acyltransferase YP_002471342.1 homology (Evalue<1e-4) to COG0119 [E] Isopropylmalate/homocitrate/citramalate synthases YP_002471343.1 Catalyzes the conversion of citrate to isocitrate YP_002471344.1 homology (Evalue<1e-4) to COG2873 [E] O-acetylhomoserine sulfhydrylase YP_002471345.1 homology (Evalue<1e-4) to COG1410 [E] Methionine synthase I, cobalamin-binding domain YP_002471347.1 homology (Evalue<1e-4) to COG0834 [E] ABC-type amino acid transport system, periplasmic component YP_002471348.1 homology (Evalue<1e-4) to COG0765 [E] ABC-type amino acid transport system, permease component YP_002471349.1 homology (Evalue<1e-4) to COG1126 [E] ABC-type polar amino acid transport system, ATPase component YP_002471350.1 catalyzes the formation of 2-N(omega)-(L-arginino)succinate from L-citrulline and L-aspartate in arginine biosynthesis, AMP-forming YP_002471351.1 catalyzes the formation of arginine from (N-L-arginino)succinate YP_002471352.1 homology (Evalue<1e-4) to COG2155 [S] Uncharacterized BCR YP_002471353.1 homology (Evalue<1e-4) to COG1522 [K] Transcriptional regulators YP_002471354.1 homology (Evalue<1e-4) to COG0017 [J] Aspartyl/asparaginyl-tRNA synthetases YP_002471356.1 homology (Evalue<1e-4) to COG0663 [R] Carbonic anhydrases/acetyltransferases, isoleucine patch superfamily YP_002471357.1 homology (Evalue<1e-4) to COG2866 [E] Predicted carboxypeptidase YP_002471358.1 homology (Evalue<1e-4) to COG1728 [S] Uncharacterized BCR YP_002471359.1 homology (Evalue<1e-4) to COG0474 [P] Cation transport ATPases YP_002471360.1 homology (Evalue<1e-4) to COG2996 [S] Uncharacterized BCR YP_002471361.1 catalyzes the formation of nicotinamide adenine dinucleotide (NAD) from nicotinic acid adenine dinucleotide (NAAD) using either ammonia or glutamine as the amide donor and ATP; ammonia-utilizing enzymes include the ones from Bacillus and Escherichia coli while glutamine-utilizing enzymes include the Mycobacterial one; forms homodimers YP_002471362.1 homology (Evalue<1e-4) to COG1585 [NO] Membrane protein implicated in regulation of membrane protease activity YP_002471363.1 homology (Evalue<1e-4) to COG0330 [O] Membrane protease subunits, stomatin/prohibitin homologs YP_002471365.1 homology (Evalue<1e-4) to COG2887 [L] RecB family exonuclease YP_002471366.1 catalyzes the conversion of a phosphate monoester to an alcohol and a phosphate YP_002471367.1 homology (Evalue<1e-4) to COG0176 [G] Transaldolase YP_002471369.1 Member of the extracytoplasmic function sigma factors which are active under specific conditions; binds with the catalytic core of RNA polymerase to produce the holoenzyme and directs bacterial core RNA polymerase to specific promoter elements to initiate transcription YP_002471370.1 homology (Evalue<1e-4) to COG0500 [QR] SAM-dependent methyltransferases YP_002471371.1 homology (Evalue<1e-4) to COG0626 [E] Cystathionine beta-lyases/cystathionine gamma-synthases YP_002471372.1 homology (Evalue<1e-4) to COG0031 [E] Cysteine synthase YP_002471373.1 homology (Evalue<1e-4) to COG0739 [M] Membrane proteins related to metalloendopeptidases YP_002471374.1 homology (Evalue<1e-4) to COG1442 [M] Lipopolysaccharide biosynthesis proteins, LPS:glycosyltransferases YP_002471375.1 homology (Evalue<1e-4) to COG0583 [K] Transcriptional regulator YP_002471376.1 homology (Evalue<1e-4) to COG0710 [E] 3-dehydroquinate dehydratase YP_002471377.1 AroE; catalyzes the conversion of shikimate to 3-dehydroshikimate YP_002471378.1 homology (Evalue<1e-4) to COG1902 [C] NADH:flavin oxidoreductases, Old Yellow Enzyme family YP_002471380.1 homology (Evalue<1e-4) to COG1073 [R] Hydrolases of the alpha/beta superfamily YP_002471381.1 homology (Evalue<1e-4) to COG0477 [GEPR] Permeases of the major facilitator superfamily YP_002471382.1 homology (Evalue<1e-4) to COG0477 [GEPR] Permeases of the major facilitator superfamily YP_002471383.1 catalyzes the conversion of shikimate to 3-dehydroshikimate YP_002471384.1 homology (Evalue<1e-4) to COG1902 [C] NADH:flavin oxidoreductases, Old Yellow Enzyme family YP_002471385.1 homology (Evalue<1e-4) to COG1082 [G] Sugar phosphate isomerases/epimerases YP_002471386.1 homology (Evalue<1e-4) to COG0583 [K] Transcriptional regulator YP_002471387.1 homology (Evalue<1e-4) to COG0399 [M] Predicted pyridoxal phosphate-dependent enzyme apparently involved in regulation of cell wall biogenesis YP_002471388.1 homology (Evalue<1e-4) to COG0399 [M] Predicted pyridoxal phosphate-dependent enzyme apparently involved in regulation of cell wall biogenesis YP_002471389.1 homology (Evalue<1e-4) to COG0500 [QR] SAM-dependent methyltransferases YP_002471391.1 catalyzes a two-step reaction, first charging a glutamine molecule by linking its carboxyl group to the alpha-phosphate of ATP, followed by transfer of the aminoacyl-adenylate to its tRNA YP_002471392.1 homology (Evalue<1e-4) to COG0726 [G] Predicted xylanase/chitin deacetylase YP_002471393.1 homology (Evalue<1e-4) to COG0367 [E] Asparagine synthase (glutamine-hydrolyzing) YP_002471394.1 homology (Evalue<1e-4) to COG3560 [R] Predicted oxidoreductase related to nitroreductase YP_002471395.1 homology (Evalue<1e-4) to COG2607 [R] Predicted ATPase of the AAA+ class YP_002471397.1 homology (Evalue<1e-4) to COG1670 [J] Acetyltransferases, including N-acetylases of ribosomal proteins YP_002471398.1 homology (Evalue<1e-4) to COG1636 [S] Uncharacterized BCR YP_002471399.1 homology (Evalue<1e-4) to COG1168 [E] PLP-dependent aminotransferase YP_002471401.1 homology (Evalue<1e-4) to COG1132 [Q] ABC-type multidrug/protein/lipid transport system, ATPase component YP_002471402.1 homology (Evalue<1e-4) to COG1348 [P] Nitrogenase subunit NifH (ATPase) YP_002471403.1 homology (Evalue<1e-4) to COG2710 [C] Nitrogenase molybdenum-iron protein, alpha and beta chains YP_002471404.1 homology (Evalue<1e-4) to COG2710 [C] Nitrogenase molybdenum-iron protein, alpha and beta chains YP_002471405.1 homology (Evalue<1e-4) to COG0535 [R] Predicted Fe-S oxidoreductases YP_002471406.1 homology (Evalue<1e-4) to COG0600 [P] ABC-type nitrate/sulfonate/taurine/bicarbonate transport systems, permease components YP_002471407.1 homology (Evalue<1e-4) to COG0715 [P] ABC-type nitrate/sulfonate/taurine/bicarbonate transport systems, periplasmic components YP_002471408.1 homology (Evalue<1e-4) to COG1116 [P] ABC-type nitrate/sulfonate/taurine/bicarbonate transport systems, ATPase components YP_002471409.1 homology (Evalue<1e-4) to COG0600 [P] ABC-type nitrate/sulfonate/taurine/bicarbonate transport systems, permease components YP_002471410.1 homology (Evalue<1e-4) to COG0600 [P] ABC-type nitrate/sulfonate/taurine/bicarbonate transport systems, permease components YP_002471411.1 homology (Evalue<1e-4) to COG2710 [C] Nitrogenase molybdenum-iron protein, alpha and beta chains YP_002471412.1 homology (Evalue<1e-4) to COG2710 [C] Nitrogenase molybdenum-iron protein, alpha and beta chains YP_002471413.1 homology (Evalue<1e-4) to COG2710 [C] Nitrogenase molybdenum-iron protein, alpha and beta chains YP_002471414.1 homology (Evalue<1e-4) to COG1348 [P] Nitrogenase subunit NifH (ATPase) YP_002471416.1 homology (Evalue<1e-4) to COG2710 [C] Nitrogenase molybdenum-iron protein, alpha and beta chains YP_002471417.1 homology (Evalue<1e-4) to COG2710 [C] Nitrogenase molybdenum-iron protein, alpha and beta chains YP_002471418.1 homology (Evalue<1e-4) to COG0747 [EP] ABC-type dipeptide/oligopeptide/nickel transport systems, periplasmic components YP_002471419.1 homology (Evalue<1e-4) to COG0601 [EP] ABC-type dipeptide/oligopeptide/nickel transport systems, permease components YP_002471420.1 homology (Evalue<1e-4) to COG1173 [EP] ABC-type dipeptide/oligopeptide/nickel transport systems, permease components YP_002471421.1 homology (Evalue<1e-4) to COG0444 [EP] ABC-type dipeptide/oligopeptide/nickel transport system, ATPase component YP_002471422.1 homology (Evalue<1e-4) to COG1124 [EP] ABC-type dipeptide/oligopeptide/nickel transport system, ATPase component YP_002471423.1 homology (Evalue<1e-4) to COG0500 [QR] SAM-dependent methyltransferases YP_002471424.1 homology (Evalue<1e-4) to COG0745 [TK] Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain YP_002471425.1 homology (Evalue<1e-4) to COG0642 [T] Signal transduction histidine kinase YP_002471426.1 homology (Evalue<1e-4) to COG2247 [M] cell wall-binding domain YP_002471428.1 homology (Evalue<1e-4) to COG2836 [S] Uncharacterized BCR YP_002471429.1 homology (Evalue<1e-4) to COG0840 [N] Methyl-accepting chemotaxis protein YP_002471430.1 homology (Evalue<1e-4) to COG0616 [NO] Periplasmic serine proteases (ClpP class) YP_002471431.1 homology (Evalue<1e-4) to COG0071 [O] Molecular chaperone (small heat shock protein) YP_002471433.1 homology (Evalue<1e-4) to COG0531 [E] Amino acid transporters YP_002471435.1 homology (Evalue<1e-4) to COG1454 [C] Alcohol dehydrogenase IV YP_002471436.1 decatenates replicating daughter chromosomes YP_002471437.1 homology (Evalue<1e-4) to COG1979 [C] Uncharacterized oxidoreductases, Fe-dependent alcohol dehydrogenase family YP_002471438.1 homology (Evalue<1e-4) to COG0784 [T] CheY-like receiver domain YP_002471439.1 homology (Evalue<1e-4) to COG2972 [T] Predicted signal transduction protein with a C-terminal ATPase domain YP_002471442.1 homology (Evalue<1e-4) to COG1012 [C] NAD-dependent aldehyde dehydrogenases YP_002471443.1 homology (Evalue<1e-4) to COG1454 [C] Alcohol dehydrogenase IV YP_002471444.1 homology (Evalue<1e-4) to COG1012 [C] NAD-dependent aldehyde dehydrogenases YP_002471445.1 homology (Evalue<1e-4) to COG1454 [C] Alcohol dehydrogenase IV YP_002471446.1 homology (Evalue<1e-4) to COG1454 [C] Alcohol dehydrogenase IV YP_002471447.1 homology (Evalue<1e-4) to COG0531 [E] Amino acid transporters YP_002471448.1 catalyzes the formation of (R)-2,3-dihydroxy-3-methylbutanoate from (S)-2-hydroxy-2-methyl-3-oxobutanoate in valine and isoleucine biosynthesis YP_002471449.1 homology (Evalue<1e-4) to COG0028 [EH] Thiamine pyrophosphate-requiring enzymes acetolactate synthase, pyruvate dehydrogenase (cytochrome), glyoxylate carboligase, phosphonopyruvate decarboxylase YP_002471450.1 homology (Evalue<1e-4) to COG1321 [K] Mn-dependent transcriptional regulator YP_002471451.1 homology (Evalue<1e-4) to COG2247 [M] cell wall-binding domain YP_002471452.1 homology (Evalue<1e-4) to COG2207 [K] AraC-type DNA-binding domain-containing proteins YP_002471454.1 homology (Evalue<1e-4) to COG1104 [E] Cysteine sulfinate desulfinase/cysteine desulfurase and related enzymes YP_002471455.1 catalyzes a sulfuration reaction to synthesize 2-thiouridine at the U34 position of tRNAs YP_002471456.1 catalyzes the formation of (R)-2,3-dihydroxy-3-methylbutanoate from (S)-2-hydroxy-2-methyl-3-oxobutanoate in valine and isoleucine biosynthesis YP_002471459.1 homology (Evalue<1e-4) to COG0845 [Q] Membrane-fusion protein YP_002471460.1 homology (Evalue<1e-4) to COG0841 [Q] Cation/multidrug efflux pump YP_002471461.1 homology (Evalue<1e-4) to COG1846 [K] Transcriptional regulators YP_002471463.1 homology (Evalue<1e-4) to COG3584 [S] Uncharacterized BCR YP_002471464.1 homology (Evalue<1e-4) to COG0840 [N] Methyl-accepting chemotaxis protein YP_002471465.1 homology (Evalue<1e-4) to COG0463 [M] Glycosyltransferases involved in cell wall biogenesis YP_002471466.1 homology (Evalue<1e-4) to COG2247 [M] cell wall-binding domain YP_002471467.1 homology (Evalue<1e-4) to COG2247 [M] cell wall-binding domain YP_002471468.1 homology (Evalue<1e-4) to COG2931 [Q] RTX toxins and related Ca2+-binding proteins YP_002471471.1 catalyzes the formation of L-aspartate 4-semialdehyde from L-homoserine YP_002471472.1 homology (Evalue<1e-4) to COG1180 [O] Pyruvate-formate lyase-activating enzyme YP_002471473.1 homology (Evalue<1e-4) to COG1882 [C] Pyruvate-formate lyase YP_002471474.1 homology (Evalue<1e-4) to COG0642 [T] Signal transduction histidine kinase YP_002471475.1 homology (Evalue<1e-4) to COG2200 [T] EAL domain YP_002471476.1 homology (Evalue<1e-4) to COG1989 [N] Signal peptidase, cleaves prepilin-like proteins YP_002471477.1 homology (Evalue<1e-4) to COG2165 [N] General secretory pathway proteins G and H and related periplasmic/secreted proteins YP_002471478.1 homology (Evalue<1e-4) to COG2804 [N] Predicted ATPases involved in pili biogenesis, PilB homologs YP_002471479.1 homology (Evalue<1e-4) to COG1459 [N] General secretory pathway protein F YP_002471480.1 homology (Evalue<1e-4) to COG0849 [D] Predicted ATPases of the HSP70 class involved in cell division YP_002471482.1 homology (Evalue<1e-4) to COG3210 [M] hemagglutinin/hemolysin YP_002471486.1 homology (Evalue<1e-4) to COG1032 [C] Fe-S oxidoreductases family 2 YP_002471487.1 homology (Evalue<1e-4) to COG0784 [T] CheY-like receiver domain YP_002471488.1 homology (Evalue<1e-4) to COG0643 [N] Chemotaxis protein histidine kinase and related kinases YP_002471489.1 homology (Evalue<1e-4) to COG0835 [N] Chemotaxis signal transduction protein YP_002471490.1 homology (Evalue<1e-4) to COG0840 [N] Methyl-accepting chemotaxis protein YP_002471491.1 homology (Evalue<1e-4) to COG0589 [T] Universal stress protein UspA and related nucleotide-binding proteins YP_002471492.1 homology (Evalue<1e-4) to COG0589 [T] Universal stress protein UspA and related nucleotide-binding proteins YP_002471493.1 homology (Evalue<1e-4) to COG2707 [S] Uncharacterized membrane protein YP_002471496.1 homology (Evalue<1e-4) to COG2931 [Q] RTX toxins and related Ca2+-binding proteins YP_002471498.1 homology (Evalue<1e-4) to COG0840 [N] Methyl-accepting chemotaxis protein YP_002471499.1 homology (Evalue<1e-4) to COG1331 [R] Highly conserved protein containing a thioredoxin domain YP_002471503.1 homology (Evalue<1e-4) to COG2217 [P] Cation transport ATPases YP_002471506.1 homology (Evalue<1e-4) to COG1285 [S] Uncharacterized membrane protein YP_002471507.1 catalyzes the formation of dUMP from dUTP YP_002471509.1 homology (Evalue<1e-4) to COG0346 [E] Lactoylglutathione lyase and related lyases YP_002471510.1 homology (Evalue<1e-4) to COG0629 [L] Single-stranded DNA-binding protein YP_002471512.1 homology (Evalue<1e-4) to COG1344 [N] Flagellin and related hook-associated proteins YP_002471513.1 with FlgF and C makes up the proximal portion of the flagellar basal body rod YP_002471514.1 with FlgF and B makes up the proximal portion of the flagellar basal body rod YP_002471515.1 forms a junction between the M-ring and FlgB during flagella biosynthesis YP_002471516.1 the MS-ring anchors the flagellum to the cytoplasmic membrane; part of the flagellar basal body which consists of four rings L, P, S, and M mounted on a central rod YP_002471517.1 One of three proteins involved in switching the direction of the flagellar rotation YP_002471518.1 homology (Evalue<1e-4) to COG1317 [N] Flagellar biosynthesis/type III secretory pathway protein YP_002471519.1 homology (Evalue<1e-4) to COG1157 [N] Flagellar biosynthesis/type III secretory pathway ATPase YP_002471520.1 homology (Evalue<1e-4) to COG2882 [N] Flagellar biosynthesis chaperone YP_002471521.1 homology (Evalue<1e-4) to COG3144 [N] Flagellar hook-length control protein YP_002471522.1 homology (Evalue<1e-4) to COG1843 [N] Flagellar hook capping protein YP_002471523.1 homology (Evalue<1e-4) to COG1749 [N] Flagellar basal body and hook proteins YP_002471524.1 homology (Evalue<1e-4) to COG1582 [N] Uncharacterized protein, possibly involved in motility YP_002471525.1 homology (Evalue<1e-4) to COG1580 [N] Flagellar basal body-associated protein YP_002471527.1 FliP, with proteins FliQ and FliR, forms the core of the central channel in the flagella export apparatus YP_002471528.1 homology (Evalue<1e-4) to COG1987 [N] Flagellar biosynthesis/type III secretory pathway protein YP_002471529.1 FlhB is a membrane protein responsible for substrate specificity in switching from rod/hook-type export to filament-type export; FliR is required for export of flagellar proteins, although a specific role has not yet been determined YP_002471530.1 membrane protein involved in the flagellar export apparatus YP_002471531.1 positive regulator of class III flagellar genes YP_002471532.1 homology (Evalue<1e-4) to COG0455 [D] ATPases involved in chromosome partitioning YP_002471533.1 homology (Evalue<1e-4) to COG1191 [K] DNA-directed RNA polymerase specialized sigma subunit YP_002471535.1 makes up the distal portion of the flagellar basal body rod; the Clostridia have two adjacent copies of the FlgG gene YP_002471536.1 makes up the distal portion of the flagellar basal body rod; the Clostridia have 2 adjacent copies of the FlgG gene YP_002471539.1 catalyzes the hydrolysis of pyrophosphate to phosphate YP_002471540.1 homology (Evalue<1e-4) to COG0474 [P] Cation transport ATPases YP_002471542.1 homology (Evalue<1e-4) to COG1067 [O] Predicted ATP-dependent protease YP_002471543.1 translation-associated GTPase; the crystal structure of the Haemophilus influenzae YchF protein showed similarity to the yeast structure (PDB: 1NI3); fluorescence spectroscopy revealed nucleic acid binding; the yeast protein YBR025c interacts with the translation elongation factor eEF1 YP_002471544.1 homology (Evalue<1e-4) to COG0275 [M] Predicted S-adenosylmethionine-dependent methyltransferase involved in cell envelope biogenesis YP_002471546.1 homology (Evalue<1e-4) to COG0768 [M] Cell division protein FtsI/penicillin-binding protein 2 YP_002471547.1 involved in cell wall formation; peptidoglycan synthesis; cytoplasmic enzyme; catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-aceylmuramoyl-l-alanyl-d-glutamate YP_002471548.1 homology (Evalue<1e-4) to COG0770 [M] UDP-N-acetylmuramyl pentapeptide synthase YP_002471549.1 First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan YP_002471550.1 homology (Evalue<1e-4) to COG0772 [D] Bacterial cell division membrane protein YP_002471551.1 homology (Evalue<1e-4) to COG1589 [M] Cell division septal protein YP_002471555.1 homology (Evalue<1e-4) to COG0325 [R] Predicted enzyme with a TIM-barrel fold YP_002471556.1 homology (Evalue<1e-4) to COG1799 [S] Uncharacterized BCR YP_002471557.1 homology (Evalue<1e-4) to COG0762 [S] Predicted integral membrane protein YP_002471558.1 homology (Evalue<1e-4) to COG2302 [S] Uncharacterized BCR, contains S4-like domain YP_002471559.1 homology (Evalue<1e-4) to COG3599 [D] Cell division initiation protein YP_002471560.1 enables the cleavage of the glycosidic bond in both 5'-methylthioadenosine and S-adenosylhomocysteine YP_002471561.1 lipoprotein signal peptidase; integral membrane protein that removes signal peptides from prolipoproteins during lipoprotein biosynthesis YP_002471562.1 homology (Evalue<1e-4) to COG0564 [J] Pseudouridylate synthases, 23S RNA-specific YP_002471563.1 homology (Evalue<1e-4) to COG2233 [F] Xanthine/uracil permeases YP_002471564.1 regulates pyrimidine biosynthesis by binding to the mRNA of the pyr genes, also has been shown to have uracil phosphoribosyltransferase activity YP_002471565.1 homology (Evalue<1e-4) to COG1293 [K] Predicted RNA-binding protein homologous to eukaryotic snRNP YP_002471566.1 involved in lysine biosynthesis; DAP epimerase; produces DL-diaminopimelate from LL-diaminopimelate YP_002471568.1 homology (Evalue<1e-4) to COG2804 [N] Predicted ATPases involved in pili biogenesis, PilB homologs YP_002471569.1 homology (Evalue<1e-4) to COG1459 [N] General secretory pathway protein F YP_002471570.1 homology (Evalue<1e-4) to COG2165 [N] General secretory pathway proteins G and H and related periplasmic/secreted proteins YP_002471577.1 homology (Evalue<1e-4) to COG0006 [E] Xaa-Pro aminopeptidase YP_002471578.1 Involved in peptide bond synthesis; alters the affinity of the ribosome for aminoacyl-tRNA YP_002471581.1 necessary for complete engulfment of forespore YP_002471588.1 homology (Evalue<1e-4) to COG1302 [S] Uncharacterized BCR YP_002471589.1 Regulates rRNA biosynthesis by transcriptional antitermination YP_002471590.1 bidirectionally degrades single-stranded DNA into large acid-insoluble oligonucleotides YP_002471591.1 homology (Evalue<1e-4) to COG1722 [L] Exonuclease VII small subunit YP_002471592.1 homology (Evalue<1e-4) to COG0142 [H] Geranylgeranyl pyrophosphate synthase YP_002471593.1 catalyzes the formation of 1-deoxy-D-xylulose 5-phosphate from pyruvate and D-glyceraldehyde 3-phosphate YP_002471594.1 homology (Evalue<1e-4) to COG1189 [J] Predicted rRNA methylases YP_002471595.1 homology (Evalue<1e-4) to COG0061 [R] Predicted kinase YP_002471596.1 regulates arginine biosynthesis when complexed with arginine by binding at site that overlap the promotors of the arginine biosynthesis genes YP_002471597.1 homology (Evalue<1e-4) to COG0497 [L] ATPases involved in DNA repair YP_002471598.1 homology (Evalue<1e-4) to COG0750 [M] Predicted membrane-associated Zn-dependent proteases 1 YP_002471599.1 homology (Evalue<1e-4) to COG0784 [T] CheY-like receiver domain YP_002471600.1 homology (Evalue<1e-4) to COG0494 [LR] NTP pyrophosphohydrolases including oxidative damage repair enzymes YP_002471601.1 homology (Evalue<1e-4) to COG1300 [S] Uncharacterized membrane protein YP_002471603.1 homology (Evalue<1e-4) to COG0582 [L] Integrase YP_002471604.1 catalyzes the transfer of phosphate between the C1 and C5 carbons of pentose YP_002471605.1 homology (Evalue<1e-4) to COG0213 [F] Thymidine phosphorylase YP_002471606.1 homology (Evalue<1e-4) to COG2445 [S] Uncharacterized ACR YP_002471607.1 homology (Evalue<1e-4) to COG1708 [R] Predicted nucleotidyltransferases YP_002471608.1 homology (Evalue<1e-4) to COG0840 [N] Methyl-accepting chemotaxis protein YP_002471609.1 homology (Evalue<1e-4) to COG2206 [T] HD-GYP domain YP_002471610.1 homology (Evalue<1e-4) to COG0778 [C] Nitroreductase YP_002471612.1 homology (Evalue<1e-4) to COG2206 [T] HD-GYP domain YP_002471613.1 homology (Evalue<1e-4) to COG2221 [C] Oxidoreductase related to nitrite reductase YP_002471614.1 homology (Evalue<1e-4) to COG1751 [S] Uncharacterized ACR YP_002471615.1 homology (Evalue<1e-4) to COG1686 [M] D-alanyl-D-alanine carboxypeptidase YP_002471616.1 homology (Evalue<1e-4) to COG0617 [J] tRNA nucleotidyltransferase/poly(A) polymerase YP_002471617.1 functions during chromosome segregation; may form a condensin-like structure with SMC and ScpB YP_002471618.1 functions during chromosome segregation; may form a condensin-like structure with SMC and ScpA; forms a homodimer YP_002471621.1 homology (Evalue<1e-4) to COG1686 [M] D-alanyl-D-alanine carboxypeptidase YP_002471623.1 homology (Evalue<1e-4) to COG0840 [N] Methyl-accepting chemotaxis protein YP_002471624.1 homology (Evalue<1e-4) to COG3086 [T] Positive regulator of sigma E activity YP_002471625.1 homology (Evalue<1e-4) to COG1726 [C] Na+-transporting NADH:ubiquinone oxidoreductase alpha subunit YP_002471626.1 homology (Evalue<1e-4) to COG1805 [C] Na+-transporting NADH:ubiquinone oxidoreductase subunit 2 YP_002471627.1 homology (Evalue<1e-4) to COG2869 [C] Na+-transporting NADH:ubiquinone oxidoreductase gamma subunit YP_002471628.1 homology (Evalue<1e-4) to COG1347 [C] Na+-transporting NADH:ubiquinone oxidoreductase subunit 4 YP_002471629.1 homology (Evalue<1e-4) to COG2209 [C] Na+-transporting NADH:ubiquinone oxidoreductase subunit 5 YP_002471630.1 homology (Evalue<1e-4) to COG2878 [C] Predicted alternative beta subunit of Na+-transporting NADH:ubiquinone oxidoreductase YP_002471634.1 homology (Evalue<1e-4) to COG0561 [R] Predicted hydrolases of the HAD superfamily YP_002471635.1 with component II, the glutamine amidotransferase, catalyzes the formation of anthranilate from chorismate and glutamine YP_002471636.1 homology (Evalue<1e-4) to COG0512 [EH] Anthranilate/para-aminobenzoate synthases component II YP_002471637.1 Catalyzes the conversion of N-(5-phospho-D-ribosyl)-anthranilate and diphosphate to anthranilate and 5-phospho-alpha-D-ribose 1-diphosphate YP_002471638.1 involved in tryptophan biosynthesis; amino acid biosynthesis; converts 1-(2-carboxyphenylamino)-1-deoxy-D-ribulose 5-phosphate to C(1)-(3-indolyl)-glycerol 3-phosphate and carbon dioxide and water YP_002471639.1 homology (Evalue<1e-4) to COG0135 [E] Phosphoribosylanthranilate isomerase YP_002471640.1 catalyzes the formation of L-tryptophan from L-serine and 1-(indol-3-yl)glycerol 3-phosphate YP_002471641.1 catalyzes the formation of indole and glyceraldehyde 3-phosphate from indoleglycerol phosphate in tryptophan biosynthesis YP_002471642.1 homology (Evalue<1e-4) to COG1937 [S] Uncharacterized BCR YP_002471643.1 homology (Evalue<1e-4) to COG3610 [S] Uncharacterized BCR YP_002471644.1 homology (Evalue<1e-4) to COG2966 [S] Uncharacterized BCR YP_002471645.1 catalyzes the reaction of glycine with 5,10-methylenetetrahydrofolate to form L-serine and tetrahydrofolate YP_002471647.1 homology (Evalue<1e-4) to COG0046 [F] Phosphoribosylformylglycinamidine (FGAM) synthase, synthetase domain YP_002471648.1 homology (Evalue<1e-4) to COG1131 [Q] ABC-type multidrug transport system, ATPase component YP_002471651.1 homology (Evalue<1e-4) to COG0642 [T] Signal transduction histidine kinase YP_002471652.1 homology (Evalue<1e-4) to COG1307 [S] Uncharacterized BCR YP_002471653.1 homology (Evalue<1e-4) to COG0840 [N] Methyl-accepting chemotaxis protein YP_002471654.1 homology (Evalue<1e-4) to COG3705 [E] ATP phosphoribosyltransferase involved in histidine biosynthesis YP_002471655.1 short form of enzyme; requires HisZ for function; catalyzes the formation of N'-5'-phosphoribosyl-ATP from phosphoribosyl pyrophosphate; crucial role in histidine biosynthesis; forms heteromultimer of HisG and HisZ YP_002471656.1 catalyzes the oxidation of L-histidinol to L-histidinaldehyde and then to L-histidine in histidine biosynthesis; functions as a dimer YP_002471657.1 homology (Evalue<1e-4) to COG0079 [E] Histidinol-phosphate aminotransferase/Tyrosine aminotransferase YP_002471658.1 homology (Evalue<1e-4) to COG0131 [E] Imidazoleglycerol-phosphate dehydratase YP_002471659.1 with HisF IGPS catalyzes the conversion of phosphoribulosyl-formimino-5-aminoimidazole-4-carboxamide ribonucleotide phosphate and glutamine to imidazole-glycerol phosphate, 5-aminoimidazol-4-carboxamide ribonucleotide, and glutamate in histidine biosynthesis; the HisH subunit provides the glutamine amidotransferase activity that produces the ammonia necessary to HisF for the synthesis of imidazole-glycerol phosphate and 5-aminoimidazol-4-carboxamide ribonucleotide YP_002471660.1 catalyzes the formation of 5-(5-phospho-1-deoxyribulos-1-ylamino)methylideneamino-l- (5-phosphoribosyl)imidazole-4-carboxamide from 1-(5-phosphoribosyl)-5-[(5- phosphoribosylamino)methylideneamino] imidazole-4-carboxamide YP_002471661.1 catalyzes the conversion of 5-[(5-phospho-1-deoxyribulos-1-ylamino)methylideneamino]- 1-(5-phosphoribosyl)imidazole-4-carboxamideand glutamine to imidazole-glycerol phosphate, 5-aminoimidazol-4-carboxamideribonucleotide and glutamate; the HisF subunit acts as a cyclase YP_002471662.1 PR-AMP cyclohydrolase; functions in histidine biosynthesis from PRPP; converts 1-(5-phosphoribosyl)-AMP to 1-(5-phosphoribosyl)-5-[(5- phosphoribosylamino)methylideneamino]imidazole-4- carboxyamide during the histidine biosynthesis pathway; binds zinc and magnesium; forms homodimers YP_002471663.1 catalyzes the formation of 1-(5-phosphoribosyl)-AMP from 1-(5-phosphoribolsyl)-ATP in histidine biosynthesis YP_002471666.1 homology (Evalue<1e-4) to COG1387 [ER] Histidinol phosphatase and related hydrolases of the PHP family YP_002471669.1 homology (Evalue<1e-4) to COG1408 [R] Predicted phosphohydrolases YP_002471670.1 homology (Evalue<1e-4) to COG2256 [L] Uncharacterized ATPase related to the helicase subunit of the Holliday junction resolvase YP_002471671.1 homology (Evalue<1e-4) to COG1396 [K] Predicted transcriptional regulators YP_002471672.1 homology (Evalue<1e-4) to COG0747 [EP] ABC-type dipeptide/oligopeptide/nickel transport systems, periplasmic components YP_002471673.1 homology (Evalue<1e-4) to COG0601 [EP] ABC-type dipeptide/oligopeptide/nickel transport systems, permease components YP_002471674.1 homology (Evalue<1e-4) to COG1173 [EP] ABC-type dipeptide/oligopeptide/nickel transport systems, permease components YP_002471675.1 homology (Evalue<1e-4) to COG0444 [EP] ABC-type dipeptide/oligopeptide/nickel transport system, ATPase component YP_002471676.1 homology (Evalue<1e-4) to COG1124 [EP] ABC-type dipeptide/oligopeptide/nickel transport system, ATPase component YP_002471677.1 homology (Evalue<1e-4) to COG2355 [E] Zn-dependent dipeptidase, microsomal dipeptidase homolog YP_002471678.1 homology (Evalue<1e-4) to COG1959 [K] Predicted transcriptional regulator YP_002471679.1 homology (Evalue<1e-4) to COG1104 [E] Cysteine sulfinate desulfinase/cysteine desulfurase and related enzymes YP_002471680.1 homology (Evalue<1e-4) to COG0822 [C] NifU homologs involved in Fe-S cluster formation YP_002471682.1 homology (Evalue<1e-4) to COG0628 [R] Predicted permease YP_002471684.1 homology (Evalue<1e-4) to COG2247 [M] cell wall-binding domain YP_002471685.1 Catalyzes a two-step reaction, first charging an alanyl molecule by linking its carboxyl group to the alpha-phosphate of ATP, followed by transfer of the aminoacyl-adenylate to its tRNA YP_002471687.1 similar to RuvC resolvase with substantial differences; NMR structural information suggests this protein is monomeric; unknown cellular function YP_002471689.1 homology (Evalue<1e-4) to COG0735 [P] Fe2+/Zn2+ uptake regulation proteins YP_002471690.1 homology (Evalue<1e-4) to COG0595 [R] Predicted hydrolase of the metallo-beta-lactamase superfamily YP_002471691.1 homology (Evalue<1e-4) to COG1217 [N] Predicted membrane GTPase involved in stress response YP_002471692.1 homology (Evalue<1e-4) to COG1559 [R] Predicted periplasmic solute-binding protein YP_002471693.1 homology (Evalue<1e-4) to COG0500 [QR] SAM-dependent methyltransferases YP_002471694.1 homology (Evalue<1e-4) to COG0826 [O] Collagenase and related proteases YP_002471695.1 homology (Evalue<1e-4) to COG0768 [M] Cell division protein FtsI/penicillin-binding protein 2 YP_002471696.1 sigma-28; sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released; this sigma factor is responsible for the expression of sporulation specific genes and is expressed in the mother cell after engulfment YP_002471697.1 homology (Evalue<1e-4) to COG2805 [N] Predicted ATPases involved in pili biogenesis, PilT homologs YP_002471698.1 homology (Evalue<1e-4) to COG1215 [M] Glycosyltransferases, probably involved in cell wall biogenesis YP_002471699.1 homology (Evalue<1e-4) to COG0849 [D] Predicted ATPases of the HSP70 class involved in cell division YP_002471700.1 GTPase; similar structure to tubulin; forms ring-shaped polymers at the site of cell division; other proteins such as FtsA, ZipA, and ZapA, interact with and regulate FtsZ function YP_002471702.1 sigma-29; sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released; this sigma factor is responsible for the expression of sporulation specific genes and is expressed in the mother cell at the onset of sporulation YP_002471703.1 sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released; this sigma factor is responsible for the expression of sporulation specific genes and is expressed after engulfment; this factor is involved in the transcription of small acid-soluble proteins involved in protecting the forespore chromatin YP_002471704.1 homology (Evalue<1e-4) to COG1873 [S] Uncharacterized ACR YP_002471705.1 homology (Evalue<1e-4) to COG1327 [K] Predicted transcriptional regulator, consists of a Zn-ribbon and ATP-cone domains YP_002471706.1 homology (Evalue<1e-4) to COG1496 [S] Uncharacterized ACR YP_002471707.1 homology (Evalue<1e-4) to COG0745 [TK] Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain YP_002471708.1 homology (Evalue<1e-4) to COG0642 [T] Signal transduction histidine kinase YP_002471709.1 homology (Evalue<1e-4) to COG0226 [P] ABC-type phosphate transport system, periplasmic component YP_002471710.1 homology (Evalue<1e-4) to COG0573 [P] ABC-type phosphate transport system, permease component YP_002471711.1 homology (Evalue<1e-4) to COG0581 [P] ABC-type phosphate transport system, permease component YP_002471712.1 homology (Evalue<1e-4) to COG1117 [P] ABC-type phosphate transport system, ATPase component YP_002471713.1 homology (Evalue<1e-4) to COG0704 [P] Phosphate uptake regulator YP_002471714.1 homology (Evalue<1e-4) to COG1392 [P] Phosphate transport regulator (distant homolog of PhoU) YP_002471715.1 homology (Evalue<1e-4) to COG0306 [P] Phosphate/sulphate permeases YP_002471716.1 homology (Evalue<1e-4) to COG1625 [C] Fe-S oxidoreductase, related to NifB/MoaA family YP_002471717.1 EngA; essential Neisserial GTPase; synchronizes cellular events by interacting with multiple targets with tandem G-domains; overexpression in Escherichia coli suppresses rrmJ mutation; structural analysis of the Thermotoga maritima ortholog shows different nucleotide binding affinities in the two binding domains YP_002471718.1 catalyzes the NAD(P)H-dependent reduction of glycerol 3-phosphate to glycerone phosphate YP_002471719.1 homology (Evalue<1e-4) to COG1807 [M] 4-amino-4-deoxy-L-arabinose transferase and related glycosyltransferases of PMT family YP_002471720.1 homology (Evalue<1e-4) to COG0745 [TK] Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain YP_002471721.1 homology (Evalue<1e-4) to COG0642 [T] Signal transduction histidine kinase YP_002471722.1 homology (Evalue<1e-4) to COG0463 [M] Glycosyltransferases involved in cell wall biogenesis YP_002471723.1 homology (Evalue<1e-4) to COG0542 [O] ATPases with chaperone activity, ATP-binding subunit YP_002471724.1 homology (Evalue<1e-4) to COG1561 [S] Uncharacterized stress-induced protein YP_002471725.1 homology (Evalue<1e-4) to COG2052 [S] Uncharacterized BCR YP_002471726.1 Essential for recycling GMP and indirectly, cGMP YP_002471727.1 Promotes RNA polymerase assembly; latches the N- and C-terminal regions of the beta' subunit thereby facilitating its interaction with the beta and alpha subunits YP_002471728.1 catalyzes the conjugation of cysteine to 4'-phosphopantothenate to form 4-phosphopantothenoylcysteine, which is then decarboxylated to form 4'-phosphopantotheine YP_002471729.1 binding of PriA to forked DNA starts the assembly of the primosome, also possesses 3'-5' helicase activity YP_002471730.1 cleaves off formyl group from N-terminal methionine residues of newly synthesized proteins; binds iron(2+) YP_002471731.1 modifies the free amino group of the aminoacyl moiety of methionyl-tRNA(fMet) which is important in translation initiation; inactivation of this gene in Escherichia coli severely impairs growth YP_002471732.1 homology (Evalue<1e-4) to COG2738 [R] Predicted Zn-dependent protease YP_002471733.1 homology (Evalue<1e-4) to COG0144 [J] tRNA and rRNA cytosine-C5-methylases YP_002471734.1 23S rRNA m2A2503 methyltransferase; methylates the C2 position of the A2530 nucleotide in 23S rRNA; may be involved in antibiotic resistance YP_002471735.1 homology (Evalue<1e-4) to COG0631 [T] Protein serine/threonine phosphatases YP_002471736.1 homology (Evalue<1e-4) to COG0515 [T] Serine/threonine protein kinases YP_002471737.1 EngC; RsgA; CpgA; circularly permuted GTPase; ribosome small subunit-dependent GTPase A; has the pattern G4-G1-G3 as opposed to other GTPases; interacts strongly with 30S ribosome which stimulates GTPase activity YP_002471738.1 catalyzes the interconversion of D-ribulose 5-phosphate to xylulose 5-phosphate YP_002471739.1 homology (Evalue<1e-4) to COG1564 [H] Thiamine pyrophosphokinase YP_002471741.1 required for 70S ribosome assembly YP_002471742.1 homology (Evalue<1e-4) to COG0039 [C] Malate/lactate dehydrogenases YP_002471743.1 homology (Evalue<1e-4) to COG1302 [S] Uncharacterized BCR YP_002471744.1 homology (Evalue<1e-4) to COG1461 [R] Predicted kinase related to dihydroxyacetone kinase YP_002471745.1 catalyzes branch migration in Holliday junction intermediates YP_002471746.1 homology (Evalue<1e-4) to COG0742 [L] N6-adenine-specific methylase YP_002471747.1 Catalyzes the conversion of ATP and pantetheine 4'-phosphate to diphosphate and 3'-dephospho-coA YP_002471749.1 homology (Evalue<1e-4) to COG3314 [S] Uncharacterized BCR YP_002471750.1 homology (Evalue<1e-4) to COG1323 [S] Uncharacterized ACR YP_002471751.1 in Salmonella this enzyme is required for ethanolamine catabolism; has higher affinity for CoA than Pta YP_002471752.1 homology (Evalue<1e-4) to COG0282 [C] Acetate kinase YP_002471753.1 homology (Evalue<1e-4) to COG1399 [R] Predicted metal-binding, possibly nucleic acid-binding protein YP_002471754.1 some L32 proteins have zinc finger motifs consisting of CXXC while others do not YP_002471755.1 involved in acylation of glycerol-3-phosphate to form 1-acyl-glycerol-3 phosphate for use in phospholipid biosynthesis; functions with PlsY YP_002471756.1 carries the fatty acid chain in fatty acid biosynthesis YP_002471757.1 cytoplasmic enzyme involved in processing rRNA and some mRNAs; substrates typically have dsRNA regions; forms a homodimer; have N-terminal nuclease and C-terminal RNA-binding domains; requires magnesium as preferred ion for activity YP_002471758.1 homology (Evalue<1e-4) to COG1243 [K] ELP3 component of the RNA polymerase II complex, consists of an N-terminal BioB/LipA-like domain and a C-terminal histone acetyltransferase domain (only BioB/LipA-like domain in Thermotoga) YP_002471759.1 homology (Evalue<1e-4) to COG1196 [D] Chromosome segregation ATPases YP_002471760.1 homology (Evalue<1e-4) to COG0552 [N] Signal recognition particle GTPase YP_002471761.1 homology (Evalue<1e-4) to COG2739 [S] Uncharacterized BCR YP_002471762.1 homology (Evalue<1e-4) to COG0541 [N] Signal recognition particle GTPase YP_002471763.1 binds to lower part of 30S body where it stabilizes two domains; required for efficient assembly of 30S; in Escherichia coli this protein has nuclease activity YP_002471764.1 homology (Evalue<1e-4) to COG1837 [R] Predicted RNA-binding protein (KH domain) YP_002471765.1 Essential for efficient processing of 16S rRNA YP_002471766.1 methylates guanosine-37 in various tRNAs; uses S-adenosyl-L-methionine to transfer methyl group to tRNA YP_002471767.1 this protein is located at the 30S-50S ribosomal subunit interface and may play a role in the structure and function of the aminoacyl-tRNA binding site YP_002471768.1 homology (Evalue<1e-4) to COG0681 [N] Signal peptidase I YP_002471769.1 essential GTPase; functions in ribosome assembly; binds a unique part of the 23S rRNA; interacts with ribosomal protein L25(Ctc) YP_002471770.1 RNH2; RNase HII; binds manganese; endonuclease which specifically degrades the RNA of RNA-DNA hybrids YP_002471771.1 homology (Evalue<1e-4) to COG0792 [L] Predicted endonuclease distantly related to archaeal Holliday junction resolvase YP_002471772.1 homology (Evalue<1e-4) to COG0606 [O] Predicted ATPase with chaperone activity YP_002471773.1 homology (Evalue<1e-4) to COG0648 [L] Endonuclease IV YP_002471774.1 homology (Evalue<1e-4) to COG0758 [LN] Predicted Rossmann fold nucleotide-binding protein involved in DNA uptake YP_002471775.1 catalyzes the ATP-dependent breakage of single-stranded DNA followed by passage and rejoining, maintains net negative superhelicity YP_002471776.1 CodY; DNA-binding protein that represses the expression of many genes that are induced as cells make the transition from rapid exponential growth to stationary phase (By similarity). It is a GTP-binding protein that senses the intracellular GTP concentration as an indicator of nutritional limitations. At low GTP concentration it no longer binds GTP and stop to act as a transcriptional repressor YP_002471777.1 one of the last subunits in the assembly of the 30S subunit; absence of S2 does not inhibit assembly but results in an inactive subunit YP_002471778.1 EF-Ts; functions during elongation stage of protein translation; forms a dimer; associates with EF-Tu-GDP complex and promotes exchange of GDP to GTP resulting in regeneration of the active form of EF-Tu YP_002471779.1 Catalyzes the phosphorylation of UMP to UDP YP_002471780.1 Rrf; Frr; ribosome-recycling factor; release factor 4; RF4; recycles ribosomes upon translation termination along with release factor RF-3 and elongation factor EF-G; A GTPase-dependent process results in release of 50S from 70S; inhibited by release factor RF-1; essential for viability; structurally similar to tRNAs YP_002471781.1 catalyzes the formation of undecaprenyl pyrophosphate from isopentenyl pyrophosphate YP_002471782.1 homology (Evalue<1e-4) to COG0575 [I] CDP-diglyceride synthetase YP_002471783.1 catalyzes the NADP-dependent rearrangement and reduction of 1-deoxy-D-xylulose-5-phosphate (DXP) to 2-C-methyl-D-erythritol 4-phosphate YP_002471784.1 homology (Evalue<1e-4) to COG0750 [M] Predicted membrane-associated Zn-dependent proteases 1 YP_002471785.1 catalyzes the conversion of 2C-methyl-D-erythritol 2,4-cyclodiphosphate into 4-hydroxy-3-methyl-2-en-1-yl diphosphate; involved in isoprenoid synthesis YP_002471786.1 catalyzes DNA-template-directed extension of the 3'- end of a DNA strand by one nucleotide at a time; required for leading strand synthesis; PolC exhibits 3' to 5' exonuclease activity YP_002471787.1 in Streptococcus pneumoniae this gene was found to be essential; structure determination of the Streptococcus protein shows that it is similar to a number of other proteins YP_002471788.1 modifies transcription through interactions with RNA polymerase affecting elongation, readthrough, termination, and antitermination YP_002471789.1 homology (Evalue<1e-4) to COG2740 [K] Predicted nucleic-acid-binding protein implicated in transcription termination YP_002471790.1 homology (Evalue<1e-4) to COG1358 [J] Ribosomal protein HS6-type (S12/L30/L7a) YP_002471791.1 Protects formylmethionyl-tRNA from spontaneous hydrolysis and promotes its binding to the 30S ribosomal subunits during initiation of protein synthesis. Also involved in the hydrolysis of GTP during the formation of the 70S ribosomal complex YP_002471792.1 associates with free 30S ribosomal subunits; essential for efficient processing of 16S rRNA; in Escherichia coli rbfA is induced by cold shock YP_002471793.1 homology (Evalue<1e-4) to COG0618 [R] Exopolyphosphatase-related proteins YP_002471794.1 catalyzes isomerization of specific uridines in RNA to pseudouridine; responsible for residues in T loops of many tRNAs YP_002471795.1 catalyzes the formation of FMN from riboflavin and the formation of FAD from FMN; in Bacillus the ribC gene has both flavokinase and FAD synthetase activities YP_002471796.1 primary rRNA binding protein; helps nucleate assembly of 30S; binds directly to the 16S rRNA and an intersubunit bridge to the 23S rRNA; autoregulates translation through interactions with the mRNA leader sequence YP_002471797.1 homology (Evalue<1e-4) to COG1185 [J] Polyribonucleotide nucleotidyltransferase (polynucleotide phosphorylase) YP_002471798.1 homology (Evalue<1e-4) to COG0612 [R] Predicted Zn-dependent peptidases YP_002471799.1 homology (Evalue<1e-4) to COG1873 [S] Uncharacterized ACR YP_002471800.1 catalyzes the formation of 4-phospho-L-aspartate from L-aspartate and ATP; diaminopimelate sensitive YP_002471801.1 homology (Evalue<1e-4) to COG0740 [NO] Protease subunit of ATP-dependent Clp proteases YP_002471802.1 homology (Evalue<1e-4) to COG1674 [D] DNA segregation ATPase FtsK/SpoIIIE and related proteins YP_002471803.1 homology (Evalue<1e-4) to COG0621 [J] 2-methylthioadenine synthetase YP_002471804.1 homology (Evalue<1e-4) to COG0558 [I] Phosphatidylglycerophosphate synthase YP_002471805.1 catalyzes the hydrolysis of ATP in the presence of single-stranded DNA, the ATP-dependent uptake of single-stranded DNA by duplex DNA, and the ATP-dependent hybridization of homologous single-stranded DNAs YP_002471806.1 protein from Staphylococcus aureus has phosphodiesterase activity against 2'-3'-cAMP and 2'-3'-cGMP YP_002471807.1 homology (Evalue<1e-4) to COG2359 [S] Uncharacterized BCR YP_002471808.1 catalyzes the formation of decaprenylphosphoryl-5-phosphoribose from phosphoribose diphosphate and decaprenyl phosphate YP_002471809.1 homology (Evalue<1e-4) to COG1807 [M] 4-amino-4-deoxy-L-arabinose transferase and related glycosyltransferases of PMT family YP_002471810.1 homology (Evalue<1e-4) to COG0697 [GER] Permeases of the drug/metabolite transporter (DMT) superfamily YP_002471811.1 catalyzes the formation of oxalozcetate and L-glutamate from L-aspartate and 2-oxoglutarate YP_002471812.1 homology (Evalue<1e-4) to COG1925 [G] Phosphotransferase system, HPr-related proteins YP_002471813.1 homology (Evalue<1e-4) to COG2155 [S] Uncharacterized BCR YP_002471814.1 Catalyzes two discrete reactions in the de novo synthesis of purines: the cleavage of adenylosuccinate and succinylaminoimidazole carboxamide ribotide YP_002471815.1 homology (Evalue<1e-4) to COG0532 [J] Translation initiation factor 2 (GTPase) YP_002471816.1 Charges one glutamine molecule and pairs it to its corresponding RNA trinucleotide during protein translation YP_002471817.1 homology (Evalue<1e-4) to COG0057 [G] Glyceraldehyde-3-phosphate dehydrogenase/erythrose-4-phosphate dehydrogenase YP_002471818.1 homology (Evalue<1e-4) to COG1686 [M] D-alanyl-D-alanine carboxypeptidase YP_002471819.1 homology (Evalue<1e-4) to COG0494 [LR] NTP pyrophosphohydrolases including oxidative damage repair enzymes YP_002471820.1 homology (Evalue<1e-4) to COG1846 [K] Transcriptional regulators YP_002471823.1 homology (Evalue<1e-4) to COG1846 [K] Transcriptional regulators YP_002471824.1 homology (Evalue<1e-4) to COG0477 [GEPR] Permeases of the major facilitator superfamily YP_002471826.1 homology (Evalue<1e-4) to COG0642 [T] Signal transduction histidine kinase YP_002471827.1 catalyzes the formation of 5-phospho-alpha-D-ribose 1-diphosphate and nicotinate from nicotinate D-ribonucleotide and diphosphate YP_002471828.1 homology (Evalue<1e-4) to COG0210 [L] Superfamily I DNA and RNA helicases YP_002471829.1 homology (Evalue<1e-4) to COG2205 [T] Osmosensitive K+ channel histidine kinase YP_002471830.1 homology (Evalue<1e-4) to COG0745 [TK] Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain YP_002471831.1 catalyzes the hydrolysis of ATP coupled with the exchange of hydrogen and potassium ions YP_002471832.1 One of the components of the high-affinity ATP-driven potassium transport (or KDP) system, which catalyzes the hydrolysis of ATP coupled with the exchange of hydrogen and potassium ions YP_002471833.1 one of the components of the high-affinity ATP-driven potassium transport (or KDP)system, which catalyzes the hydrolysis of ATP coupled with the exchange of hydrogen and potassium ions; the C subunit may be involved in assembly of the KDP complex YP_002471834.1 homology (Evalue<1e-4) to COG0138 [F] AICAR transformylase/IMP cyclohydrolase PurH (only IMP cyclohydrolase domain in Aful) YP_002471835.1 homology (Evalue<1e-4) to COG1335 [Q] Amidases related to nicotinamidase YP_002471836.1 homology (Evalue<1e-4) to COG1268 [R] Uncharacterized ACR YP_002471837.1 homology (Evalue<1e-4) to COG0840 [N] Methyl-accepting chemotaxis protein YP_002471838.1 homology (Evalue<1e-4) to COG0849 [D] Predicted ATPases of the HSP70 class involved in cell division YP_002471839.1 homology (Evalue<1e-4) to COG1473 [R] Metal-dependent amidase/aminoacylase/carboxypeptidase YP_002471840.1 homology (Evalue<1e-4) to COG0564 [J] Pseudouridylate synthases, 23S RNA-specific YP_002471841.1 homology (Evalue<1e-4) to COG2244 [R] Membrane protein involved in the export of O-antigen and teichoic acid YP_002471842.1 homology (Evalue<1e-4) to COG2244 [R] Membrane protein involved in the export of O-antigen and teichoic acid YP_002471846.1 homology (Evalue<1e-4) to COG1032 [C] Fe-S oxidoreductases family 2 YP_002471848.1 catalyzes the phosphorylation of the phosphocarrier protein HPr of the bacterial phosphotransferase system YP_002471849.1 homology (Evalue<1e-4) to COG0212 [H] 5-formyltetrahydrofolate cyclo-ligase YP_002471850.1 homology (Evalue<1e-4) to COG0477 [GEPR] Permeases of the major facilitator superfamily YP_002471851.1 homology (Evalue<1e-4) to COG2339 [S] Uncharacterized membrane protein YP_002471852.1 homology (Evalue<1e-4) to COG0745 [TK] Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain YP_002471853.1 homology (Evalue<1e-4) to COG0642 [T] Signal transduction histidine kinase YP_002471854.1 homology (Evalue<1e-4) to COG2226 [H] Methylase involved in ubiquinone/menaquinone biosynthesis YP_002471855.1 homology (Evalue<1e-4) to COG1266 [R] Predicted metal-dependent membrane protease YP_002471856.1 homology (Evalue<1e-4) to COG1575 [H] 1,4-dihydroxy-2-naphthoate octaprenyltransferase YP_002471857.1 homology (Evalue<1e-4) to COG0644 [C] Dehydrogenases (flavoproteins) YP_002471858.1 homology (Evalue<1e-4) to COG2440 [C] Ferredoxin-like protein YP_002471862.1 homology (Evalue<1e-4) to COG3208 [Q] Predicted thioesterase involved in non-ribosomal peptide biosynthesis YP_002471863.1 homology (Evalue<1e-4) to COG1021 [Q] Peptide arylation enzymes YP_002471864.1 homology (Evalue<1e-4) to COG1020 [Q] Non-ribosomal peptide synthetase modules and related proteins YP_002471866.1 homology (Evalue<1e-4) to COG1020 [Q] Non-ribosomal peptide synthetase modules and related proteins YP_002471867.1 homology (Evalue<1e-4) to COG1020 [Q] Non-ribosomal peptide synthetase modules and related proteins YP_002471870.1 homology (Evalue<1e-4) to COG1020 [Q] Non-ribosomal peptide synthetase modules and related proteins YP_002471871.1 homology (Evalue<1e-4) to COG1132 [Q] ABC-type multidrug/protein/lipid transport system, ATPase component YP_002471872.1 homology (Evalue<1e-4) to COG1132 [Q] ABC-type multidrug/protein/lipid transport system, ATPase component YP_002471874.1 homology (Evalue<1e-4) to COG0619 [P] ABC-type cobalt transport system, permease component CbiQ and related transporters YP_002471875.1 homology (Evalue<1e-4) to COG1122 [P] ABC-type cobalt transport system, ATPase component YP_002471876.1 homology (Evalue<1e-4) to COG0534 [Q] Na+-driven multidrug efflux pump YP_002471877.1 homology (Evalue<1e-4) to COG1819 [GC] Glycosyl transferases, related to UDP-glucuronosyltransferase YP_002471878.1 homology (Evalue<1e-4) to COG1131 [Q] ABC-type multidrug transport system, ATPase component YP_002471880.1 homology (Evalue<1e-4) to COG2091 [Q] Phosphopantetheinyl transferase YP_002471881.1 homology (Evalue<1e-4) to COG3208 [Q] Predicted thioesterase involved in non-ribosomal peptide biosynthesis YP_002471882.1 homology (Evalue<1e-4) to COG1020 [Q] Non-ribosomal peptide synthetase modules and related proteins YP_002471883.1 homology (Evalue<1e-4) to COG0477 [GEPR] Permeases of the major facilitator superfamily YP_002471884.1 homology (Evalue<1e-4) to COG3321 [Q] Polyketide synthase modules and related proteins YP_002471888.1 homology (Evalue<1e-4) to COG0716 [C] Flavodoxins YP_002471889.1 homology (Evalue<1e-4) to COG2768 [R] Uncharacterized Fe-S center protein YP_002471890.1 homology (Evalue<1e-4) to COG0726 [G] Predicted xylanase/chitin deacetylase YP_002471891.1 homology (Evalue<1e-4) to COG1309 [K] Transcriptional regulator YP_002471892.1 homology (Evalue<1e-4) to COG0477 [GEPR] Permeases of the major facilitator superfamily YP_002471893.1 homology (Evalue<1e-4) to COG2199 [T] GGDEF domain YP_002471894.1 homology (Evalue<1e-4) to COG0598 [P] Mg2+ and Co2+ transporters YP_002471895.1 catalyzes the removal of amino acids from the N termini of peptides YP_002471896.1 homology (Evalue<1e-4) to COG0613 [R] Predicted metal-dependent phosphoesterases (PHP family) YP_002471900.1 homology (Evalue<1e-4) to COG2703 [P] Hemerythrin YP_002471901.1 homology (Evalue<1e-4) to COG0833 [E] Amino acid transporters YP_002471902.1 catalyzes the formation of fumarate from aspartate YP_002471903.1 homology (Evalue<1e-4) to COG1087 [M] UDP-glucose 4-epimerase YP_002471904.1 catalyzes a two-step reaction, first charging an arginine molecule by linking its carboxyl group to the alpha-phosphate of ATP, followed by transfer of the aminoacyl-adenylate to its tRNA; class-I aminoacyl-tRNA synthetase YP_002471905.1 homology (Evalue<1e-4) to COG3359 [L] Predicted exonuclease YP_002471906.1 homology (Evalue<1e-4) to COG0517 [R] CBS domains YP_002471907.1 homology (Evalue<1e-4) to COG0560 [E] Phosphoserine phosphatase YP_002471909.1 catalyzes the reduction of N-acetyl-5-glutamyl phosphate to N-acetyl-L-glutamate 5-semialdehyde in arginine biosynthesis and the reduction of N-acetyl-gamma-aminoadipyl-phosphate to N-acetyl-L-aminoadipate-semialdehyde in lysine biosynthesis; involved in both the arginine and lysine biosynthetic pathways; lysine is produced via the AAA pathway, lysine from alpha-aminoadipate YP_002471910.1 homology (Evalue<1e-4) to COG1364 [R] Predicted kinase related to thiamine pyrophosphokinase YP_002471911.1 catalyzes the phosphorylation of N-acetyl-L-glutamate to form N-acetyl-L-glutamate 5-phosphate YP_002471912.1 homology (Evalue<1e-4) to COG0160 [E] PLP-dependent aminotransferases YP_002471913.1 homology (Evalue<1e-4) to COG1357 [S] Uncharacterized low-complexity proteins YP_002471914.1 catalyzes the hydrolysis of S-ribosylhomocysteine to homocysteine and autoinducer-2 YP_002471915.1 homology (Evalue<1e-4) to COG1179 [H] Dinucleotide-utilizing enzymes involved in molybdopterin and thiamine biosynthesis family 1 YP_002471916.1 homology (Evalue<1e-4) to COG0388 [R] Predicted amidohydrolase YP_002471917.1 homology (Evalue<1e-4) to COG1215 [M] Glycosyltransferases, probably involved in cell wall biogenesis YP_002471918.1 homology (Evalue<1e-4) to COG1187 [J] 16S rRNA uridine-516 pseudouridylate synthase and related pseudouridylate synthases YP_002471919.1 homology (Evalue<1e-4) to COG1737 [K] Transcriptional regulators YP_002471920.1 homology (Evalue<1e-4) to COG2081 [R] Predicted flavoproteins YP_002471921.1 Catalyzes the formation of (d)CDP from ATP and (d)CMP YP_002471922.1 these proteins appear to have resulted from a fusion of lytB and rpsA; catalyzes the conversion of 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate into isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP); functions in the nonmevalonate isoprenoid biosynthesis pathway YP_002471923.1 Decarboxylation of S-adenosylmethionine provides the aminopropyl moiety required for spermidine biosynthesis from putrescine YP_002471924.1 homology (Evalue<1e-4) to COG0456 [R] Acetyltransferases YP_002471925.1 catalyzes the formation of oxalozcetate and L-glutamate from L-aspartate and 2-oxoglutarate YP_002471927.1 homology (Evalue<1e-4) to COG0500 [QR] SAM-dependent methyltransferases YP_002471928.1 catalyzes the formation of 2-methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine from N6-(dimethylallyl)adenosine (i(6)A) YP_002471929.1 This protein performs the mismatch recognition step during the DNA repair process YP_002471930.1 homology (Evalue<1e-4) to COG0323 [L] DNA mismatch repair enzyme (predicted ATPase) YP_002471931.1 IPP transferase; isopentenyltransferase; involved in tRNA modification; in Escherichia coli this enzyme catalyzes the addition of a delta2-isopentenyl group from dimethylallyl diphosphate to the N6-nitrogen of adenosine adjacent to the anticodon of tRNA species that read codons starting with uracil; further tRNA modifications may occur; mutations in miaA result in defects in translation efficiency and fidelity YP_002471932.1 homology (Evalue<1e-4) to COG1923 [R] Uncharacterized ACR, host factor I protein YP_002471933.1 homology (Evalue<1e-4) to COG0626 [E] Cystathionine beta-lyases/cystathionine gamma-synthases YP_002471934.1 Represses a number of genes involved in the response to DNA damage YP_002471937.1 site-specific tyrosine recombinase which cuts and rejoins DNA molecules; binds cooperatively to specific DNA consensus sites; forms a heterotetrameric complex with XerC; XerCD exhibit similar sequences; essential to convert chromosome dimers to monomers during cell division and functions during plasmid segregation; cell division protein FtsK may regulate the XerCD complex; enzyme from Streptococcus group has unusual active site motifs YP_002471938.1 homology (Evalue<1e-4) to COG3580 [S] Uncharacterized BCR YP_002471939.1 homology (Evalue<1e-4) to COG3581 [S] Uncharacterized BCR YP_002471940.1 homology (Evalue<1e-4) to COG1924 [I] Activator of 2-hydroxyglutaryl-CoA dehydratase (HSP70-class ATPase domain) YP_002471941.1 homology (Evalue<1e-4) to COG1284 [S] Uncharacterized BCR YP_002471947.1 homology (Evalue<1e-4) to COG2323 [S] Predicted membrane protein YP_002471948.1 homology (Evalue<1e-4) to COG1752 [R] Predicted esterase of the alpha-beta hydrolase superfamily YP_002471950.1 homology (Evalue<1e-4) to COG1940 [K] Transcriptional regulators YP_002471951.1 homology (Evalue<1e-4) to COG0366 [G] Glycosidases YP_002471952.1 homology (Evalue<1e-4) to COG1918 [P] Fe2+ transport system YP_002471953.1 homology (Evalue<1e-4) to COG0370 [P] Fe2+ transport system YP_002471954.1 homology (Evalue<1e-4) to COG1918 [P] Fe2+ transport system YP_002471956.1 homology (Evalue<1e-4) to COG0290 [J] Translation initiation factor IF3 YP_002471957.1 homology (Evalue<1e-4) to COG1757 [C] Na+/H+ antiporter YP_002471958.1 homology (Evalue<1e-4) to COG1914 [P] Mn2+ and Fe2+ transporters of the NRAMP family YP_002471959.1 homology (Evalue<1e-4) to COG3339 [S] Uncharacterized ACR YP_002471960.1 homology (Evalue<1e-4) to COG0005 [F] Purine nucleoside phosphorylase YP_002471961.1 catalyzes the formation of O-succinyl-L-homoserine from succinyl-CoA and L-homoserine in methionine biosynthesis YP_002471962.1 homology (Evalue<1e-4) to COG1595 [K] DNA-directed RNA polymerase specialized sigma subunits, sigma24 homologs YP_002471963.1 homology (Evalue<1e-4) to COG1557 [S] Predicted membrane protein YP_002471964.1 homology (Evalue<1e-4) to COG1012 [C] NAD-dependent aldehyde dehydrogenases YP_002471965.1 homology (Evalue<1e-4) to COG3682 [K] Predicted transcriptional regulator YP_002471967.1 homology (Evalue<1e-4) to COG0440 [E] Acetolactate synthase, small subunit YP_002471968.1 homology (Evalue<1e-4) to COG0028 [EH] Thiamine pyrophosphate-requiring enzymes acetolactate synthase, pyruvate dehydrogenase (cytochrome), glyoxylate carboligase, phosphonopyruvate decarboxylase YP_002471969.1 homology (Evalue<1e-4) to COG0493 [ER] NADPH-dependent glutamate synthase beta chain and related oxidoreductases YP_002471970.1 homology (Evalue<1e-4) to COG0069 [E] Glutamate synthase domain 2 YP_002471972.1 homology (Evalue<1e-4) to COG1611 [R] Predicted Rossmann fold nucleotide-binding protein YP_002471973.1 Converts L-aspartate to beta-alanine and provides the major route of beta-alanine production in bacteria. Beta-alanine is essential for the biosynthesis of pantothenate (vitamin B5) YP_002471974.1 homology (Evalue<1e-4) to COG2755 [E] Lysophospholipase L1 and related esterases YP_002471975.1 homology (Evalue<1e-4) to COG0105 [F] Nucleoside diphosphate kinase YP_002471979.1 homology (Evalue<1e-4) to COG1511 [S] Predicted membrane protein YP_002471980.1 homology (Evalue<1e-4) to COG1511 [S] Predicted membrane protein YP_002471981.1 homology (Evalue<1e-4) to COG1897 [E] Homoserine trans-succinylase YP_002471982.1 homology (Evalue<1e-4) to COG0626 [E] Cystathionine beta-lyases/cystathionine gamma-synthases YP_002471983.1 homology (Evalue<1e-4) to COG0192 [H] S-adenosylmethionine synthetase YP_002471984.1 homology (Evalue<1e-4) to COG2340 [S] Uncharacterized protein with SCP/PR1 domains YP_002471985.1 homology (Evalue<1e-4) to COG0352 [H] Thiamine monophosphate synthase YP_002471986.1 in Escherichia coli this enzyme functions in thiamine biosynthesis along with thiFSGI and iscS; with ThiFSG catalyzes the formation of thiazole phosphate from tyrosine, cysteine and 1-deoxy-D-xylulose-5-phosphate; forms a complex with ThiG; contains an iron-sulfur center YP_002471987.1 functions in thiamine (vitamin B1) biosynthesis; in Bacillus subtilis this enzyme catalyzes the formation of thiazole from dehydroxyglycine and 1-deoxy-D-xylulose-5-phosphate and ThiS-thiocarboxylate YP_002471988.1 catalyzes the adenylation of ThiS which is involved in the formation of 5-methyl-4-(beta-hydroxyethyl)thiazole phosphate YP_002471989.1 homology (Evalue<1e-4) to COG2104 [H] Sulfur transfer protein involved in thiamine biosynthesis YP_002471991.1 homology (Evalue<1e-4) to COG1695 [K] Predicted transcriptional regulators YP_002471992.1 homology (Evalue<1e-4) to COG0642 [T] Signal transduction histidine kinase YP_002471993.1 homology (Evalue<1e-4) to COG0745 [TK] Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain YP_002471994.1 homology (Evalue<1e-4) to COG0577 [R] ABC-type transport systems, involved in lipoprotein release, permease components YP_002471995.1 homology (Evalue<1e-4) to COG1136 [R] ABC-type transport systems, involved in lipoprotein release, ATPase components YP_002471996.1 homology (Evalue<1e-4) to COG1396 [K] Predicted transcriptional regulators YP_002472000.1 homology (Evalue<1e-4) to COG0477 [GEPR] Permeases of the major facilitator superfamily YP_002472001.1 homology (Evalue<1e-4) to COG1846 [K] Transcriptional regulators YP_002472002.1 homology (Evalue<1e-4) to COG0322 [L] Nuclease subunit of the excinuclease complex YP_002472003.1 homology (Evalue<1e-4) to COG0574 [G] Phosphoenolpyruvate synthase/pyruvate phosphate dikinase YP_002472004.1 homology (Evalue<1e-4) to COG1309 [K] Transcriptional regulator YP_002472005.1 homology (Evalue<1e-4) to COG1393 [P] Arsenate reductase and related proteins, glutaredoxin family YP_002472006.1 homology (Evalue<1e-4) to COG0577 [R] ABC-type transport systems, involved in lipoprotein release, permease components YP_002472007.1 homology (Evalue<1e-4) to COG0577 [R] ABC-type transport systems, involved in lipoprotein release, permease components YP_002472008.1 homology (Evalue<1e-4) to COG0675 [L] Predicted transposases YP_002472009.1 homology (Evalue<1e-4) to COG1136 [R] ABC-type transport systems, involved in lipoprotein release, ATPase components YP_002472023.1 homology (Evalue<1e-4) to COG1695 [K] Predicted transcriptional regulators YP_002472026.1 homology (Evalue<1e-4) to COG1595 [K] DNA-directed RNA polymerase specialized sigma subunits, sigma24 homologs YP_002472028.1 homology (Evalue<1e-4) to COG0642 [T] Signal transduction histidine kinase YP_002472029.1 homology (Evalue<1e-4) to COG0745 [TK] Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain YP_002472030.1 homology (Evalue<1e-4) to COG1277 [R] ABC-type transport system involved in multi-copper enzyme maturation, permease component YP_002472031.1 homology (Evalue<1e-4) to COG1131 [Q] ABC-type multidrug transport system, ATPase component YP_002472033.1 homology (Evalue<1e-4) to COG0534 [Q] Na+-driven multidrug efflux pump YP_002472034.1 homology (Evalue<1e-4) to COG0406 [G] Fructose-2,6-bisphosphatase YP_002472035.1 homology (Evalue<1e-4) to COG1902 [C] NADH:flavin oxidoreductases, Old Yellow Enzyme family YP_002472036.1 homology (Evalue<1e-4) to COG1670 [J] Acetyltransferases, including N-acetylases of ribosomal proteins YP_002472037.1 homology (Evalue<1e-4) to COG0488 [R] ATPase components of ABC transporters with duplicated ATPase domains YP_002472038.1 catalyzes the dehydration of 2,3-dihydroxy-3-methylbutanoate to 3-methyl-2-oxobutanoate in valine and isoleucine biosynthesis YP_002472039.1 homology (Evalue<1e-4) to COG2186 [K] Transcriptional regulators YP_002472040.1 homology (Evalue<1e-4) to COG0840 [N] Methyl-accepting chemotaxis protein YP_002472041.1 catalyzes the formation of biotin from dethiobiotin and sulfur 2 S-adenosyl-L-methionine YP_002472043.1 homology (Evalue<1e-4) to COG2247 [M] cell wall-binding domain YP_002472045.1 homology (Evalue<1e-4) to COG0531 [E] Amino acid transporters YP_002472048.1 homology (Evalue<1e-4) to COG0535 [R] Predicted Fe-S oxidoreductases YP_002472049.1 homology (Evalue<1e-4) to COG0609 [PH] ABC-type cobalamin/Fe3+-siderophores transport systems, permease components YP_002472050.1 homology (Evalue<1e-4) to COG1120 [PH] ABC-type cobalamin/Fe3+-siderophores transport systems, ATPase components YP_002472051.1 homology (Evalue<1e-4) to COG0614 [P] ABC-type cobalamin/Fe3+-siderophores transport systems, periplasmic components YP_002472053.1 homology (Evalue<1e-4) to COG0640 [K] Predicted transcriptional regulators YP_002472054.1 homology (Evalue<1e-4) to COG0701 [R] Predicted permeases YP_002472055.1 homology (Evalue<1e-4) to COG0526 [OC] Thiol-disulfide isomerase and thioredoxins YP_002472056.1 homology (Evalue<1e-4) to COG2801 [L] transposase YP_002472057.1 homology (Evalue<1e-4) to COG2801 [L] transposase YP_002472058.1 homology (Evalue<1e-4) to COG0394 [T] Protein-tyrosine-phosphatase YP_002472059.1 exports sodium by using the electrochemical proton gradient to allow protons into the cell; functions in adaptation to high salinity and alkaline pH; activity increases at higher pH; downregulated at acidic pH YP_002472060.1 homology (Evalue<1e-4) to COG0726 [G] Predicted xylanase/chitin deacetylase YP_002472061.1 homology (Evalue<1e-4) to COG1309 [K] Transcriptional regulator YP_002472062.1 homology (Evalue<1e-4) to COG0477 [GEPR] Permeases of the major facilitator superfamily YP_002472063.1 homology (Evalue<1e-4) to COG3464 [L] Transposase YP_002472064.1 homology (Evalue<1e-4) to COG3464 [L] Transposase YP_002472066.1 homology (Evalue<1e-4) to COG2801 [L] transposase YP_002472067.1 homology (Evalue<1e-4) to COG2801 [L] transposase YP_002472068.1 homology (Evalue<1e-4) to COG0534 [Q] Na+-driven multidrug efflux pump YP_002472069.1 homology (Evalue<1e-4) to COG3321 [Q] Polyketide synthase modules and related proteins YP_002472070.1 homology (Evalue<1e-4) to COG3321 [Q] Polyketide synthase modules and related proteins YP_002472071.1 homology (Evalue<1e-4) to COG0331 [I] (acyl-carrier-protein) S-malonyltransferase YP_002472072.1 homology (Evalue<1e-4) to COG1020 [Q] Non-ribosomal peptide synthetase modules and related proteins YP_002472073.1 homology (Evalue<1e-4) to COG0318 [IQ] Acyl-CoA synthetases (AMP-forming)/AMP-acid ligases II YP_002472074.1 homology (Evalue<1e-4) to COG3208 [Q] Predicted thioesterase involved in non-ribosomal peptide biosynthesis YP_002472075.1 homology (Evalue<1e-4) to COG2091 [Q] Phosphopantetheinyl transferase YP_002472076.1 homology (Evalue<1e-4) to COG0582 [L] Integrase YP_002472077.1 homology (Evalue<1e-4) to COG0582 [L] Integrase YP_002472079.1 homology (Evalue<1e-4) to COG0614 [P] ABC-type cobalamin/Fe3+-siderophores transport systems, periplasmic components YP_002472080.1 homology (Evalue<1e-4) to COG1910 [P] Periplasmic molybdate-binding protein (domain) YP_002472081.1 homology (Evalue<1e-4) to COG2710 [C] Nitrogenase molybdenum-iron protein, alpha and beta chains YP_002472082.1 homology (Evalue<1e-4) to COG2710 [C] Nitrogenase molybdenum-iron protein, alpha and beta chains YP_002472083.1 homology (Evalue<1e-4) to COG2710 [C] Nitrogenase molybdenum-iron protein, alpha and beta chains YP_002472085.1 homology (Evalue<1e-4) to COG2710 [C] Nitrogenase molybdenum-iron protein, alpha and beta chains YP_002472086.1 nitrogenase iron protein; nitrogenase component 2; with component 1, an molybdenum-iron protein, catalyzes the fixation of nitrogen to ammonia; nitrogen reductase provides electrons to the nitrogenase complex; alternative NifH, may be molybdenum-independent YP_002472087.1 homology (Evalue<1e-4) to COG0535 [R] Predicted Fe-S oxidoreductases YP_002472091.1 homology (Evalue<1e-4) to COG0347 [E] Nitrogen regulatory protein PII YP_002472092.1 homology (Evalue<1e-4) to COG0347 [E] Nitrogen regulatory protein PII YP_002472094.1 homology (Evalue<1e-4) to COG0535 [R] Predicted Fe-S oxidoreductases YP_002472095.1 homology (Evalue<1e-4) to COG0119 [E] Isopropylmalate/homocitrate/citramalate synthases YP_002472096.1 homology (Evalue<1e-4) to COG0119 [E] Isopropylmalate/homocitrate/citramalate synthases YP_002472097.1 homology (Evalue<1e-4) to COG0454 [KR] Histone acetyltransferase HPA2 and related acetyltransferases YP_002472099.1 homology (Evalue<1e-4) to COG3437 [KT] Response regulator containing a CheY-like receiver domain and an HD-GYP domain YP_002472100.1 catalyzes the formation of 5,10-methylenetetrahydrofolate from 5-methyltetrahydrofolate and S-adenosyl-L-homocysteine and methionine from S-adenosyl-L-methionine and L-homocysteine; expressed in B. subtilis under methionine starvation conditions YP_002472101.1 catalyzes the transfer of a methyl group from 5-methyltetrahydrofolate to homocysteine to form methionine YP_002472102.1 homology (Evalue<1e-4) to COG0317 [TK] Guanosine polyphosphate pyrophosphohydrolases/synthetases YP_002472103.1 homology (Evalue<1e-4) to COG0210 [L] Superfamily I DNA and RNA helicases YP_002472104.1 homology (Evalue<1e-4) to COG1595 [K] DNA-directed RNA polymerase specialized sigma subunits, sigma24 homologs YP_002472107.1 homology (Evalue<1e-4) to COG1249 [C] Dihydrolipoamide dehydrogenase/glutathione oxidoreductase and related enzymes YP_002472108.1 homology (Evalue<1e-4) to COG0095 [H] Lipoate-protein ligase A YP_002472109.1 acts in conjunction with GvcH to form H-protein-S-aminomethyldihydrolipoyllysine from glycine; forms a heterodimer with subunit 1 to form the P protein YP_002472110.1 homology (Evalue<1e-4) to COG0403 [E] Glycine cleavage system protein P (pyridoxal-binding), N-terminal domain YP_002472111.1 part of multienzyme complex composed of H, L, P, and T proteins which catalyzes oxidation of glycine to yield carbon dioxide, ammonia, 5,10-CH2-H4folate and a reduced pyridine nucleotide; protein H is involved in transfer of methylamine group from the P to T protein; covalently bound to a lipoyl cofactor YP_002472112.1 homology (Evalue<1e-4) to COG0404 [E] Glycine cleavage system T protein (aminomethyltransferase) YP_002472113.1 homology (Evalue<1e-4) to COG2200 [T] EAL domain YP_002472114.1 required for the synthesis of the hydromethylpyrimidine moiety of thiamine YP_002472117.1 homology (Evalue<1e-4) to COG0438 [M] Predicted glycosyltransferases YP_002472118.1 homology (Evalue<1e-4) to COG0058 [G] Glucan phosphorylase YP_002472119.1 homology (Evalue<1e-4) to COG0277 [C] FAD/FMN-containing dehydrogenases YP_002472120.1 homology (Evalue<1e-4) to COG1132 [Q] ABC-type multidrug/protein/lipid transport system, ATPase component YP_002472121.1 homology (Evalue<1e-4) to COG1132 [Q] ABC-type multidrug/protein/lipid transport system, ATPase component YP_002472122.1 homology (Evalue<1e-4) to COG1846 [K] Transcriptional regulators YP_002472123.1 homology (Evalue<1e-4) to COG1280 [E] threonine efflux protein YP_002472124.1 homology (Evalue<1e-4) to COG0531 [E] Amino acid transporters YP_002472125.1 homology (Evalue<1e-4) to COG1284 [S] Uncharacterized BCR YP_002472126.1 homology (Evalue<1e-4) to COG3706 [T] Response regulator containing a CheY-like receiver domain and a GGDEF domain YP_002472127.1 homology (Evalue<1e-4) to COG0637 [R] Predicted phosphatase/phosphohexomutase YP_002472128.1 homology (Evalue<1e-4) to COG1359 [S] Uncharacterized ACR YP_002472130.1 homology (Evalue<1e-4) to COG2303 [N] Choline dehydrogenase and related flavoproteins YP_002472131.1 homology (Evalue<1e-4) to COG0840 [N] Methyl-accepting chemotaxis protein YP_002472132.1 homology (Evalue<1e-4) to COG0050 [JE] GTPases - translation elongation factors YP_002472133.1 with CysN catalyzes the formation of adenylylsulfate from sulfate and ATP YP_002472134.1 homology (Evalue<1e-4) to COG1146 [C] Ferredoxin 3 YP_002472135.1 catalyzes the reduction of adenosine 5'-phosphosulfate to AMP and sulfite YP_002472136.1 homology (Evalue<1e-4) to COG0529 [P] Adenylylsulfate kinase and related kinases YP_002472137.1 homology (Evalue<1e-4) to COG1118 [P] ABC-type sulfate/molybdate transport systems, ATPase component YP_002472138.1 homology (Evalue<1e-4) to COG0555 [P] ABC-type sulfate/molybdate transport systems, permease components YP_002472139.1 homology (Evalue<1e-4) to COG0555 [P] ABC-type sulfate/molybdate transport systems, permease components YP_002472140.1 homology (Evalue<1e-4) to COG1613 [P] ABC-type sulfate transport system, periplasmic component YP_002472141.1 homology (Evalue<1e-4) to COG1940 [K] Transcriptional regulators YP_002472142.1 homology (Evalue<1e-4) to COG2104 [H] Sulfur transfer protein involved in thiamine biosynthesis YP_002472143.1 homology (Evalue<1e-4) to COG0476 [H] Dinucleotide-utilizing enzymes involved in molybdopterin and thiamine biosynthesis family 2 YP_002472144.1 homology (Evalue<1e-4) to COG1310 [S] Uncharacterized ACR, PAD1/JAB1-related YP_002472145.1 homology (Evalue<1e-4) to COG0155 [P] Sulfite reductase hemoprotein beta-component YP_002472146.1 homology (Evalue<1e-4) to COG2873 [E] O-acetylhomoserine sulfhydrylase YP_002472150.1 homology (Evalue<1e-4) to COG0681 [N] Signal peptidase I YP_002472153.1 homology (Evalue<1e-4) to COG0543 [HC] 2-polyprenylphenol hydroxylase and related flavodoxin oxidoreductases YP_002472155.1 homology (Evalue<1e-4) to COG1396 [K] Predicted transcriptional regulators YP_002472156.1 homology (Evalue<1e-4) to COG1278 [K] Cold shock proteins YP_002472158.1 homology (Evalue<1e-4) to COG2856 [E] Predicted Zn peptidase YP_002472162.1 homology (Evalue<1e-4) to COG3409 [M] peptidoglycan-binding domain-containing protein YP_002472167.1 homology (Evalue<1e-4) to COG0641 [R] Arylsulfatase regulator (Fe-S oxidoreductase) YP_002472170.1 homology (Evalue<1e-4) to COG3299 [S] Uncharacterized homolog of phage Mu protein gp47 YP_002472174.1 homology (Evalue<1e-4) to COG1652 [S] Uncharacterized protein containing LysM domain YP_002472176.1 homology (Evalue<1e-4) to COG3753 [S] Uncharacterized BCR YP_002472179.1 homology (Evalue<1e-4) to COG0840 [N] Methyl-accepting chemotaxis protein YP_002472180.1 homology (Evalue<1e-4) to COG3617 [K] Prophage antirepressor YP_002472181.1 homology (Evalue<1e-4) to COG1396 [K] Predicted transcriptional regulators YP_002472182.1 homology (Evalue<1e-4) to COG3646 [S] Uncharacterized phage-encoded protein YP_002472183.1 homology (Evalue<1e-4) to COG0457 [R] TPR-repeat-containing proteins YP_002472185.1 homology (Evalue<1e-4) to COG1598 [S] Uncharacterized ACR YP_002472186.1 homology (Evalue<1e-4) to COG1598 [S] Uncharacterized ACR YP_002472207.1 homology (Evalue<1e-4) to COG0484 [O] Molecular chaperones (contain C-terminal Zn finger domain) YP_002472216.1 homology (Evalue<1e-4) to COG0338 [L] Site-specific DNA methylase YP_002472217.1 homology (Evalue<1e-4) to COG0305 [L] Replicative DNA helicase YP_002472220.1 homology (Evalue<1e-4) to COG3723 [L] Recombinational DNA repair protein (RecE pathway) YP_002472224.1 homology (Evalue<1e-4) to COG1396 [K] Predicted transcriptional regulators YP_002472225.1 homology (Evalue<1e-4) to COG1396 [K] Predicted transcriptional regulators YP_002472226.1 homology (Evalue<1e-4) to COG1396 [K] Predicted transcriptional regulators YP_002472228.1 homology (Evalue<1e-4) to COG1396 [K] Predicted transcriptional regulators YP_002472229.1 homology (Evalue<1e-4) to COG1318 [K] Predicted transcriptional regulators YP_002472230.1 homology (Evalue<1e-4) to COG0419 [L] ATPase involved in DNA repair YP_002472233.1 homology (Evalue<1e-4) to COG1961 [L] Site-specific recombinases, DNA invertase Pin homologs YP_002472234.1 homology (Evalue<1e-4) to COG1206 [D] NAD(FAD)-utilizing enzyme apparently involved in cell division YP_002472235.1 homology (Evalue<1e-4) to COG0388 [R] Predicted amidohydrolase YP_002472237.1 homology (Evalue<1e-4) to COG0697 [GER] Permeases of the drug/metabolite transporter (DMT) superfamily YP_002472239.1 homology (Evalue<1e-4) to COG0596 [R] Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) YP_002472240.1 homology (Evalue<1e-4) to COG1346 [M] effector of murein hydrolase YP_002472241.1 homology (Evalue<1e-4) to COG1380 [R] effector of murein hydrolase LrgA YP_002472242.1 homology (Evalue<1e-4) to COG1592 [C] Rubrerythrin YP_002472244.1 homology (Evalue<1e-4) to COG1432 [S] Uncharacterized ACR YP_002472245.1 homology (Evalue<1e-4) to COG2246 [S] Uncharacterized membrane protein YP_002472250.1 homology (Evalue<1e-4) to COG0840 [N] Methyl-accepting chemotaxis protein YP_002472251.1 homology (Evalue<1e-4) to COG1113 [E] Gamma-aminobutyrate permease and related permeases YP_002472252.1 homology (Evalue<1e-4) to COG1284 [S] Uncharacterized BCR YP_002472253.1 homology (Evalue<1e-4) to COG0840 [N] Methyl-accepting chemotaxis protein YP_002472254.1 homology (Evalue<1e-4) to COG0591 [EHR] Na+/proline, Na+/panthothenate symporters and related permeases YP_002472255.1 homology (Evalue<1e-4) to COG0840 [N] Methyl-accepting chemotaxis protein YP_002472256.1 homology (Evalue<1e-4) to COG3287 [S] Uncharacterized ACR YP_002472261.1 homology (Evalue<1e-4) to COG2445 [S] Uncharacterized ACR YP_002472262.1 homology (Evalue<1e-4) to COG1708 [R] Predicted nucleotidyltransferases YP_002472264.1 homology (Evalue<1e-4) to COG1297 [S] Uncharacterized membrane protein YP_002472265.1 homology (Evalue<1e-4) to COG0679 [R] Predicted permeases YP_002472267.1 homology (Evalue<1e-4) to COG0665 [E] Glycine/D-amino acid oxidases (deaminating) YP_002472268.1 homology (Evalue<1e-4) to COG0446 [R] Uncharacterized NAD(FAD)-dependent dehydrogenases YP_002472269.1 homology (Evalue<1e-4) to COG1142 [C] Fe-S-cluster-containing hydrogenase components 2 YP_002472270.1 homology (Evalue<1e-4) to COG0446 [R] Uncharacterized NAD(FAD)-dependent dehydrogenases YP_002472271.1 homology (Evalue<1e-4) to COG0251 [J] translation initiation inhibitor YP_002472272.1 homology (Evalue<1e-4) to COG0111 [E] Phosphoglycerate dehydrogenase and related dehydrogenases YP_002472273.1 catalyzes the formation of succinate semialdehyde and glutamate from 4-aminobutanoate and 2-oxoglutarate YP_002472274.1 homology (Evalue<1e-4) to COG1454 [C] Alcohol dehydrogenase IV YP_002472275.1 homology (Evalue<1e-4) to COG0765 [E] ABC-type amino acid transport system, permease component YP_002472276.1 homology (Evalue<1e-4) to COG0765 [E] ABC-type amino acid transport system, permease component YP_002472277.1 homology (Evalue<1e-4) to COG0834 [E] ABC-type amino acid transport system, periplasmic component YP_002472278.1 homology (Evalue<1e-4) to COG1126 [E] ABC-type polar amino acid transport system, ATPase component YP_002472279.1 homology (Evalue<1e-4) to COG2186 [K] Transcriptional regulators YP_002472280.1 homology (Evalue<1e-4) to COG0610 [L] Restriction enzymes type I helicase subunits and related helicases YP_002472282.1 homology (Evalue<1e-4) to COG2161 [S] Uncharacterized ACR YP_002472284.1 homology (Evalue<1e-4) to COG1708 [R] Predicted nucleotidyltransferases YP_002472286.1 homology (Evalue<1e-4) to COG1708 [R] Predicted nucleotidyltransferases YP_002472290.1 homology (Evalue<1e-4) to COG3328 [L] Predicted transposase YP_002472291.1 homology (Evalue<1e-4) to COG3328 [L] Predicted transposase YP_002472295.1 homology (Evalue<1e-4) to COG0451 [MG] Nucleoside-diphosphate-sugar epimerases YP_002472297.1 homology (Evalue<1e-4) to COG3328 [L] Predicted transposase YP_002472299.1 homology (Evalue<1e-4) to COG2604 [S] Uncharacterized BCR YP_002472301.1 homology (Evalue<1e-4) to COG1086 [MG] Predicted nucleoside-diphosphate sugar epimerases YP_002472302.1 homology (Evalue<1e-4) to COG0451 [MG] Nucleoside-diphosphate-sugar epimerases YP_002472303.1 homology (Evalue<1e-4) to COG1004 [M] Predicted UDP-glucose 6-dehydrogenase YP_002472304.1 homology (Evalue<1e-4) to COG1543 [S] Uncharacterized ACR YP_002472305.1 homology (Evalue<1e-4) to COG0439 [I] Biotin carboxylase YP_002472306.1 homology (Evalue<1e-4) to COG1028 [QR] Dehydrogenases with different specificities (related to short-chain alcohol dehydrogenases) YP_002472307.1 homology (Evalue<1e-4) to COG0028 [EH] Thiamine pyrophosphate-requiring enzymes acetolactate synthase, pyruvate dehydrogenase (cytochrome), glyoxylate carboligase, phosphonopyruvate decarboxylase YP_002472308.1 homology (Evalue<1e-4) to COG0535 [R] Predicted Fe-S oxidoreductases YP_002472309.1 homology (Evalue<1e-4) to COG0500 [QR] SAM-dependent methyltransferases YP_002472310.1 homology (Evalue<1e-4) to COG0500 [QR] SAM-dependent methyltransferases YP_002472311.1 homology (Evalue<1e-4) to COG0500 [QR] SAM-dependent methyltransferases YP_002472312.1 homology (Evalue<1e-4) to COG1861 [M] Spore coat polysaccharide biosynthesis protein F, CMP-KDO synthetase homolog YP_002472313.1 homology (Evalue<1e-4) to COG2089 [M] Sialic acid synthase YP_002472314.1 homology (Evalue<1e-4) to COG2604 [S] Uncharacterized BCR YP_002472315.1 homology (Evalue<1e-4) to COG1344 [N] Flagellin and related hook-associated proteins YP_002472317.1 homology (Evalue<1e-4) to COG1345 [N] Flagellar capping protein YP_002472318.1 homology (Evalue<1e-4) to COG1516 [N] Flagellar protein YP_002472320.1 homology (Evalue<1e-4) to COG1334 [N] Uncharacterized flagellar protein FlaG YP_002472321.1 homology (Evalue<1e-4) to COG1551 [T] Carbon storage regulator (could also regulate swarming and quorum sensing) YP_002472322.1 binds to flagellin and appears to stabilize flagellin during flagella assembly YP_002472323.1 homology (Evalue<1e-4) to COG1344 [N] Flagellin and related hook-associated proteins YP_002472325.1 homology (Evalue<1e-4) to COG1256 [N] Flagellar hook-associated protein YP_002472327.1 homology (Evalue<1e-4) to COG2747 [KN] Negative regulator of flagellin synthesis (anti-sigma-28 factor) YP_002472328.1 One of three proteins involved in switching the direction of the flagellar rotation YP_002472329.1 homology (Evalue<1e-4) to COG1868 [N] Flagellar motor switch protein YP_002472330.1 homology (Evalue<1e-4) to COG0835 [N] Chemotaxis signal transduction protein YP_002472331.1 homology (Evalue<1e-4) to COG0784 [T] CheY-like receiver domain YP_002472332.1 homology (Evalue<1e-4) to COG1776 [NT] Chemotaxis protein CheC, inhibitor of MCP methylation YP_002472333.1 homology (Evalue<1e-4) to COG0643 [N] Chemotaxis protein histidine kinase and related kinases YP_002472334.1 homology (Evalue<1e-4) to COG1352 [NT] Methylase of chemotaxis methyl-accepting proteins YP_002472335.1 homology (Evalue<1e-4) to COG2201 [NT] Chemotaxis response regulator containing a CheY-like receiver domain and a methylesterase domain YP_002472336.1 catalyzes the conversion of glutamine residues to glutamate on methyl-accepting chemotaxis receptors YP_002472337.1 homology (Evalue<1e-4) to COG0835 [N] Chemotaxis signal transduction protein YP_002472338.1 homology (Evalue<1e-4) to COG1315 [S] Uncharacterized BCR YP_002472339.1 homology (Evalue<1e-4) to COG0115 [EH] Branched-chain amino acid aminotransferase/4-amino-4-deoxychorismate lyase YP_002472340.1 homology (Evalue<1e-4) to COG0560 [E] Phosphoserine phosphatase YP_002472342.1 homology (Evalue<1e-4) to COG0674 [C] Pyruvate:ferredoxin oxidoreductase and related 2-oxoacid:ferredoxin oxidoreductases, alpha subunit YP_002472343.1 UDP-N-acetylglucosamine--N-acetylmuramyl- (pentapeptide) pyrophosphoryl-undecaprenol N-acetylglucosamine transferase; involved in cell wall formation; inner membrane-associated; last step of peptidoglycan synthesis YP_002472344.1 homology (Evalue<1e-4) to COG0608 [L] Single-stranded DNA-specific exonuclease YP_002472345.1 homology (Evalue<1e-4) to COG0612 [R] Predicted Zn-dependent peptidases YP_002472346.1 homology (Evalue<1e-4) to COG0693 [R] intracellular protease/amidase YP_002472347.1 decatenates newly replicated chromosomal DNA and relaxes positive and negative DNA supercoiling YP_002472348.1 decatenates newly replicated chromosomal DNA and relaxes positive and negative DNA supercoiling YP_002472349.1 homology (Evalue<1e-4) to COG0642 [T] Signal transduction histidine kinase YP_002472350.1 homology (Evalue<1e-4) to COG0745 [TK] Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain YP_002472351.1 homology (Evalue<1e-4) to COG1308 [K] Transcription factor homologous to NACalpha-BTF3 YP_002472352.1 homology (Evalue<1e-4) to COG1151 [C] 6Fe-6S prismane cluster-containing protein YP_002472353.1 homology (Evalue<1e-4) to COG0446 [R] Uncharacterized NAD(FAD)-dependent dehydrogenases YP_002472354.1 homology (Evalue<1e-4) to COG0370 [P] Fe2+ transport system YP_002472355.1 homology (Evalue<1e-4) to COG1918 [P] Fe2+ transport system YP_002472356.1 homology (Evalue<1e-4) to COG2207 [K] AraC-type DNA-binding domain-containing proteins YP_002472357.1 homology (Evalue<1e-4) to COG0473 [E] Isocitrate/isopropylmalate dehydrogenase YP_002472358.1 homology (Evalue<1e-4) to COG0066 [E] 3-isopropylmalate dehydratase small subunit YP_002472359.1 catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate in leucine biosynthesis YP_002472360.1 homology (Evalue<1e-4) to COG0119 [E] Isopropylmalate/homocitrate/citramalate synthases YP_002472361.1 homology (Evalue<1e-4) to COG0840 [N] Methyl-accepting chemotaxis protein YP_002472362.1 homology (Evalue<1e-4) to COG3323 [S] Uncharacterized BCR YP_002472365.1 An electron-transfer protein; flavodoxin binds one FMN molecule, which serves as a redox-active prosthetic group YP_002472366.1 RibE; 6,7-diimethyl-8-ribityllumazine synthase; DMRL synthase; lumazine synthase; beta subunit of riboflavin synthase; condenses 5-amino-6-(1'-D)-ribityl-amino-2,4(1H,3H)-pyrimidinedione with L-3,4-dihydrohy-2-butanone-4-phosphate to generate 6,6-dimethyl-8-lumazine (DMRL); riboflavin synthase then uses 2 molecules of DMRL to produce riboflavin (vitamin B12); involved in the last steps of riboflavin biosynthesis; forms a 60mer (icosahedral shell) in both Bacillus subtilis and Escherichia coli; in Bacillus subtilis this 60mer is associated with the riboflavin synthase subunit (alpha) while in Escherichia coli it is not YP_002472367.1 homology (Evalue<1e-4) to COG0807 [H] GTP cyclohydrolase II YP_002472368.1 homology (Evalue<1e-4) to COG0307 [H] Riboflavin synthase alpha chain YP_002472369.1 homology (Evalue<1e-4) to COG0117 [H] Pyrimidine deaminase YP_002472371.1 homology (Evalue<1e-4) to COG1132 [Q] ABC-type multidrug/protein/lipid transport system, ATPase component YP_002472372.1 homology (Evalue<1e-4) to COG1132 [Q] ABC-type multidrug/protein/lipid transport system, ATPase component YP_002472374.1 homology (Evalue<1e-4) to COG1116 [P] ABC-type nitrate/sulfonate/taurine/bicarbonate transport systems, ATPase components YP_002472375.1 homology (Evalue<1e-4) to COG0600 [P] ABC-type nitrate/sulfonate/taurine/bicarbonate transport systems, permease components YP_002472376.1 homology (Evalue<1e-4) to COG0715 [P] ABC-type nitrate/sulfonate/taurine/bicarbonate transport systems, periplasmic components YP_002472378.1 homology (Evalue<1e-4) to COG2873 [E] O-acetylhomoserine sulfhydrylase YP_002472379.1 homology (Evalue<1e-4) to COG2267 [I] Lysophospholipase YP_002472380.1 homology (Evalue<1e-4) to COG2873 [E] O-acetylhomoserine sulfhydrylase YP_002472382.1 homology (Evalue<1e-4) to COG0071 [O] Molecular chaperone (small heat shock protein) YP_002472383.1 homology (Evalue<1e-4) to COG0454 [KR] Histone acetyltransferase HPA2 and related acetyltransferases YP_002472384.1 homology (Evalue<1e-4) to COG0620 [E] Methionine synthase II (cobalamin-independent) YP_002472385.1 homology (Evalue<1e-4) to COG0620 [E] Methionine synthase II (cobalamin-independent) YP_002472386.1 homology (Evalue<1e-4) to COG0583 [K] Transcriptional regulator YP_002472387.1 homology (Evalue<1e-4) to COG2873 [E] O-acetylhomoserine sulfhydrylase YP_002472388.1 homology (Evalue<1e-4) to COG1253 [N] Hemolysins and related proteins containing CBS domains YP_002472389.1 homology (Evalue<1e-4) to COG0735 [P] Fe2+/Zn2+ uptake regulation proteins YP_002472390.1 primary rRNA binding protein; nucleates 30S assembly; involved in translational accuracy with proteins S5 and S12; interacts with protein S5; involved in autogeneously regulating ribosomal proteins by binding to pseudoknot structures in the polycistronic mRNA; interacts with transcription complex and functions similar to protein NusA in antitermination YP_002472391.1 homology (Evalue<1e-4) to COG2755 [E] Lysophospholipase L1 and related esterases YP_002472392.1 homology (Evalue<1e-4) to COG1277 [R] ABC-type transport system involved in multi-copper enzyme maturation, permease component YP_002472393.1 homology (Evalue<1e-4) to COG1131 [Q] ABC-type multidrug transport system, ATPase component YP_002472394.1 homology (Evalue<1e-4) to COG0432 [S] Uncharacterized ACR YP_002472395.1 homology (Evalue<1e-4) to COG0789 [K] Predicted transcriptional regulators YP_002472396.1 homology (Evalue<1e-4) to COG1834 [E] N-Dimethylarginine dimethylaminohydrolase YP_002472397.1 homology (Evalue<1e-4) to COG0637 [R] Predicted phosphatase/phosphohexomutase YP_002472399.1 homology (Evalue<1e-4) to COG1595 [K] DNA-directed RNA polymerase specialized sigma subunits, sigma24 homologs YP_002472400.1 homology (Evalue<1e-4) to COG0262 [H] Dihydrofolate reductase YP_002472401.1 homology (Evalue<1e-4) to COG0537 [FGR] Diadenosine tetraphosphate (Ap4A) hydrolase and other HIT family hydrolases YP_002472403.1 homology (Evalue<1e-4) to COG1351 [F] Predicted alternative thymidylate synthase YP_002472404.1 homology (Evalue<1e-4) to COG1376 [S] Uncharacterized BCR YP_002472405.1 homology (Evalue<1e-4) to COG1406 [N] Predicted inhibitor of MCP methylation, homolog of CheC YP_002472406.1 homology (Evalue<1e-4) to COG0784 [T] CheY-like receiver domain YP_002472407.1 homology (Evalue<1e-4) to COG1893 [H] Ketopantoate reductase YP_002472408.1 homology (Evalue<1e-4) to COG1012 [C] NAD-dependent aldehyde dehydrogenases YP_002472409.1 homology (Evalue<1e-4) to COG0697 [GER] Permeases of the drug/metabolite transporter (DMT) superfamily YP_002472410.1 homology (Evalue<1e-4) to COG0477 [GEPR] Permeases of the major facilitator superfamily YP_002472411.1 molecular chaperone YP_002472414.1 homology (Evalue<1e-4) to COG1052 [CHR] Lactate dehydrogenase and related dehydrogenases YP_002472415.1 homology (Evalue<1e-4) to COG1309 [K] Transcriptional regulator YP_002472416.1 homology (Evalue<1e-4) to COG0845 [Q] Membrane-fusion protein YP_002472417.1 homology (Evalue<1e-4) to COG0842 [R] ABC-type multidrug transport system, permease component YP_002472418.1 homology (Evalue<1e-4) to COG0842 [R] ABC-type multidrug transport system, permease component YP_002472419.1 homology (Evalue<1e-4) to COG1180 [O] Pyruvate-formate lyase-activating enzyme YP_002472420.1 homology (Evalue<1e-4) to COG2078 [S] Uncharacterized ACR YP_002472421.1 homology (Evalue<1e-4) to COG2210 [S] Uncharacterized ACR YP_002472422.1 homology (Evalue<1e-4) to COG1279 [R] Lysine efflux permease YP_002472423.1 homology (Evalue<1e-4) to COG1167 [KE] Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain (MocR family) and their eukaryotic orthologs YP_002472424.1 homology (Evalue<1e-4) to COG2217 [P] Cation transport ATPases YP_002472429.1 homology (Evalue<1e-4) to COG0474 [P] Cation transport ATPases YP_002472430.1 homology (Evalue<1e-4) to COG0840 [N] Methyl-accepting chemotaxis protein YP_002472431.1 homology (Evalue<1e-4) to COG2200 [T] EAL domain YP_002472433.1 homology (Evalue<1e-4) to COG3682 [K] Predicted transcriptional regulator YP_002472434.1 homology (Evalue<1e-4) to COG1145 [C] Ferredoxin 2 YP_002472436.1 homology (Evalue<1e-4) to COG2247 [M] cell wall-binding domain YP_002472437.1 homology (Evalue<1e-4) to COG2217 [P] Cation transport ATPases YP_002472438.1 homology (Evalue<1e-4) to COG0534 [Q] Na+-driven multidrug efflux pump YP_002472442.1 homology (Evalue<1e-4) to COG1268 [R] Uncharacterized ACR YP_002472443.1 homology (Evalue<1e-4) to COG3543 [S] Uncharacterized ACR YP_002472444.1 homology (Evalue<1e-4) to COG0840 [N] Methyl-accepting chemotaxis protein YP_002472445.1 homology (Evalue<1e-4) to COG0840 [N] Methyl-accepting chemotaxis protein YP_002472446.1 catalyzes the reversible transfer of the terminal phosphate of ATP to form a long chain polyphosphate YP_002472447.1 homology (Evalue<1e-4) to COG0248 [FP] Exopolyphosphatase YP_002472448.1 homology (Evalue<1e-4) to COG0248 [FP] Exopolyphosphatase YP_002472449.1 homology (Evalue<1e-4) to COG0248 [FP] Exopolyphosphatase YP_002472450.1 homology (Evalue<1e-4) to COG0477 [GEPR] Permeases of the major facilitator superfamily YP_002472451.1 homology (Evalue<1e-4) to COG1034 [C] NADH dehydrogenase/NADH:ubiquinone oxidoreductase 75 kD subunit (chain G) YP_002472452.1 homology (Evalue<1e-4) to COG1550 [S] Uncharacterized BCR YP_002472453.1 converts homocysteine and S-adenosyl-methionine to methionine and S-adenosyl-homocysteine or S-methyl-methionine and homocysteine to two methionines YP_002472455.1 homology (Evalue<1e-4) to COG0477 [GEPR] Permeases of the major facilitator superfamily YP_002472456.1 homology (Evalue<1e-4) to COG0745 [TK] Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain YP_002472457.1 homology (Evalue<1e-4) to COG2205 [T] Osmosensitive K+ channel histidine kinase YP_002472458.1 homology (Evalue<1e-4) to COG0531 [E] Amino acid transporters YP_002472459.1 homology (Evalue<1e-4) to COG0679 [R] Predicted permeases YP_002472460.1 homology (Evalue<1e-4) to COG0768 [M] Cell division protein FtsI/penicillin-binding protein 2 YP_002472461.1 homology (Evalue<1e-4) to COG2755 [E] Lysophospholipase L1 and related esterases YP_002472462.1 homology (Evalue<1e-4) to COG1249 [C] Dihydrolipoamide dehydrogenase/glutathione oxidoreductase and related enzymes YP_002472463.1 homology (Evalue<1e-4) to COG0508 [C] Dihydrolipoamide acyltransferases YP_002472464.1 homology (Evalue<1e-4) to COG0022 [C] Thiamine pyrophosphate-dependent dehydrogenases, E1 component beta subunit YP_002472465.1 homology (Evalue<1e-4) to COG1071 [C] Thiamine pyrophosphate-dependent dehydrogenases, E1 component alpha subunit YP_002472466.1 homology (Evalue<1e-4) to COG3284 [Q] Transcriptional activator of acetoin/glycerol metabolism YP_002472467.1 catalyzes the radical-mediated insertion of two sulfur atoms into an acyl carrier protein (ACP) bound to an octanoyl group to produce a lipoyl group YP_002472468.1 homology (Evalue<1e-4) to COG0321 [H] Lipoate-protein ligase B YP_002472469.1 homology (Evalue<1e-4) to COG1266 [R] Predicted metal-dependent membrane protease YP_002472470.1 homology (Evalue<1e-4) to COG2826 [L] Transposase, IS30 family YP_002472471.1 homology (Evalue<1e-4) to COG1476 [K] Predicted transcriptional regulators YP_002472473.1 homology (Evalue<1e-4) to COG0726 [G] Predicted xylanase/chitin deacetylase YP_002472474.1 homology (Evalue<1e-4) to COG1595 [K] DNA-directed RNA polymerase specialized sigma subunits, sigma24 homologs YP_002472476.1 homology (Evalue<1e-4) to COG0697 [GER] Permeases of the drug/metabolite transporter (DMT) superfamily YP_002472478.1 homology (Evalue<1e-4) to COG1695 [K] Predicted transcriptional regulators YP_002472479.1 homology (Evalue<1e-4) to COG1309 [K] Transcriptional regulator YP_002472480.1 homology (Evalue<1e-4) to COG1136 [R] ABC-type transport systems, involved in lipoprotein release, ATPase components YP_002472481.1 homology (Evalue<1e-4) to COG0577 [R] ABC-type transport systems, involved in lipoprotein release, permease components YP_002472482.1 homology (Evalue<1e-4) to COG0716 [C] Flavodoxins YP_002472483.1 homology (Evalue<1e-4) to COG0474 [P] Cation transport ATPases YP_002472485.1 homology (Evalue<1e-4) to COG1247 [M] Sortase and related acyltransferases YP_002472487.1 homology (Evalue<1e-4) to COG1131 [Q] ABC-type multidrug transport system, ATPase component YP_002472489.1 homology (Evalue<1e-4) to COG1595 [K] DNA-directed RNA polymerase specialized sigma subunits, sigma24 homologs YP_002472490.1 homology (Evalue<1e-4) to COG2217 [P] Cation transport ATPases YP_002472492.1 homology (Evalue<1e-4) to COG0558 [I] Phosphatidylglycerophosphate synthase YP_002472493.1 homology (Evalue<1e-4) to COG1846 [K] Transcriptional regulators YP_002472494.1 homology (Evalue<1e-4) to COG0500 [QR] SAM-dependent methyltransferases YP_002472495.1 homology (Evalue<1e-4) to COG0652 [O] Peptidyl-prolyl cis-trans isomerase (rotamase) - cyclophilin family YP_002472496.1 homology (Evalue<1e-4) to COG1164 [E] Oligoendopeptidase F YP_002472497.1 functions in asparagine biosynthesis; converts glutamine, aspartate, ATP, and water to glutamate, asparagine, pyrophosphate and AMP YP_002472498.1 homology (Evalue<1e-4) to COG0457 [R] TPR-repeat-containing proteins YP_002472499.1 BacA; phosphatase activity in Escherichia coli not kinase; involved in bacitracin resistance as bacitracin supposedly sequesters undecaprenyl disphosphate which reduces the pool of lipid carrier available to the cell YP_002472501.1 homology (Evalue<1e-4) to COG0338 [L] Site-specific DNA methylase YP_002472504.1 homology (Evalue<1e-4) to COG0477 [GEPR] Permeases of the major facilitator superfamily YP_002472505.1 homology (Evalue<1e-4) to COG0642 [T] Signal transduction histidine kinase YP_002472506.1 homology (Evalue<1e-4) to COG1008 [C] NADH:ubiquinone oxidoreductase subunit 4 (chain M) YP_002472507.1 homology (Evalue<1e-4) to COG1131 [Q] ABC-type multidrug transport system, ATPase component YP_002472508.1 homology (Evalue<1e-4) to COG0745 [TK] Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain YP_002472510.1 homology (Evalue<1e-4) to COG0332 [I] 3-oxoacyl-acyl-carrier-protein synthase III YP_002472511.1 homology (Evalue<1e-4) to COG0840 [N] Methyl-accepting chemotaxis protein YP_002472512.1 homology (Evalue<1e-4) to COG1149 [C] MinD superfamily P-loop ATPase containing an inserted ferredoxin domain YP_002472513.1 SPOUT methyltransferase family protein; crystal structure shows homodimer; in Escherichia coli this protein methylates pseudouridine at position 1915 of the 23S ribosomal RNA YP_002472514.1 homology (Evalue<1e-4) to COG0488 [R] ATPase components of ABC transporters with duplicated ATPase domains YP_002472515.1 homology (Evalue<1e-4) to COG1160 [R] Predicted GTPases YP_002472516.1 catalyzes the formation of fumarate from aspartate YP_002472517.1 homology (Evalue<1e-4) to COG1002 [L] Type II restriction enzyme, methylase subunits YP_002472520.1 homology (Evalue<1e-4) to COG0542 [O] ATPases with chaperone activity, ATP-binding subunit YP_002472521.1 homology (Evalue<1e-4) to COG2127 [S] Uncharacterized ACR YP_002472522.1 homology (Evalue<1e-4) to COG0443 [O] Molecular chaperone YP_002472523.1 homology (Evalue<1e-4) to COG0443 [O] Molecular chaperone YP_002472524.1 homology (Evalue<1e-4) to COG0419 [L] ATPase involved in DNA repair YP_002472525.1 homology (Evalue<1e-4) to COG0443 [O] Molecular chaperone YP_002472526.1 homology (Evalue<1e-4) to COG0443 [O] Molecular chaperone YP_002472527.1 homology (Evalue<1e-4) to COG2310 [T] Uncharacterized proteins involved in stress response, homologs of TerZ and cAMP-binding protein CABP1 YP_002472529.1 homology (Evalue<1e-4) to COG0861 [P] Membrane protein TerC, possibly involved in tellurium resistance YP_002472530.1 homology (Evalue<1e-4) to COG1695 [K] Predicted transcriptional regulators YP_002472531.1 homology (Evalue<1e-4) to COG1307 [S] Uncharacterized BCR YP_002472533.1 homology (Evalue<1e-4) to COG1368 [M] Phosphoglycerol transferase and related proteins, alkaline phosphatase superfamily YP_002472534.1 homology (Evalue<1e-4) to COG0642 [T] Signal transduction histidine kinase YP_002472535.1 homology (Evalue<1e-4) to COG0745 [TK] Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain YP_002472536.1 homology (Evalue<1e-4) to COG0840 [N] Methyl-accepting chemotaxis protein YP_002472538.1 homology (Evalue<1e-4) to COG2267 [I] Lysophospholipase YP_002472539.1 homology (Evalue<1e-4) to COG1020 [Q] Non-ribosomal peptide synthetase modules and related proteins YP_002472540.1 homology (Evalue<1e-4) to COG3321 [Q] Polyketide synthase modules and related proteins YP_002472541.1 homology (Evalue<1e-4) to COG0331 [I] (acyl-carrier-protein) S-malonyltransferase YP_002472542.1 homology (Evalue<1e-4) to COG0318 [IQ] Acyl-CoA synthetases (AMP-forming)/AMP-acid ligases II YP_002472543.1 homology (Evalue<1e-4) to COG0577 [R] ABC-type transport systems, involved in lipoprotein release, permease components YP_002472544.1 homology (Evalue<1e-4) to COG1136 [R] ABC-type transport systems, involved in lipoprotein release, ATPase components YP_002472545.1 homology (Evalue<1e-4) to COG0845 [Q] Membrane-fusion protein YP_002472547.1 homology (Evalue<1e-4) to COG1131 [Q] ABC-type multidrug transport system, ATPase component YP_002472548.1 homology (Evalue<1e-4) to COG1725 [K] Predicted transcriptional regulators YP_002472551.1 homology (Evalue<1e-4) to COG0454 [KR] Histone acetyltransferase HPA2 and related acetyltransferases YP_002472552.1 homology (Evalue<1e-4) to COG2801 [L] transposase YP_002472553.1 homology (Evalue<1e-4) to COG0491 [R] Zn-dependent hydrolases, including glyoxylases YP_002472557.1 four CarB-CarA dimers form the carbamoyl phosphate synthetase holoenzyme that catalyzes the production of carbamoyl phosphate; CarB is responsible for the amidotransferase activity YP_002472558.1 catalyzes production of carbamoyl phosphate from bicarbonate and glutamine in pyrimidine and arginine biosynthesis pathways; forms an octamer composed of four CarAB dimers YP_002472559.1 homology (Evalue<1e-4) to COG0078 [E] Ornithine carbamoyltransferase YP_002472560.1 homology (Evalue<1e-4) to COG0834 [E] ABC-type amino acid transport system, periplasmic component YP_002472561.1 homology (Evalue<1e-4) to COG0179 [Q] 2-keto-4-pentenoate hydratase/2-oxohepta-3-ene-1,7-dioic acid hydratase (catechol pathway) YP_002472562.1 homology (Evalue<1e-4) to COG0514 [L] Superfamily II DNA helicase YP_002472563.1 homology (Evalue<1e-4) to COG0583 [K] Transcriptional regulator YP_002472564.1 homology (Evalue<1e-4) to COG2855 [S] Uncharacterized membrane protein YP_002472565.1 homology (Evalue<1e-4) to COG0526 [OC] Thiol-disulfide isomerase and thioredoxins YP_002472566.1 homology (Evalue<1e-4) to COG0326 [O] Molecular chaperone, HSP90 family YP_002472567.1 homology (Evalue<1e-4) to COG0841 [Q] Cation/multidrug efflux pump YP_002472568.1 homology (Evalue<1e-4) to COG0845 [Q] Membrane-fusion protein YP_002472569.1 homology (Evalue<1e-4) to COG1309 [K] Transcriptional regulator YP_002472571.1 homology (Evalue<1e-4) to COG1695 [K] Predicted transcriptional regulators YP_002472572.1 homology (Evalue<1e-4) to COG0477 [GEPR] Permeases of the major facilitator superfamily YP_002472573.1 homology (Evalue<1e-4) to COG3842 [E] ABC-type spermidine/putrescine transport systems, ATPase components YP_002472574.1 homology (Evalue<1e-4) to COG0600 [P] ABC-type nitrate/sulfonate/taurine/bicarbonate transport systems, permease components YP_002472575.1 homology (Evalue<1e-4) to COG0715 [P] ABC-type nitrate/sulfonate/taurine/bicarbonate transport systems, periplasmic components YP_002472576.1 homology (Evalue<1e-4) to COG1028 [QR] Dehydrogenases with different specificities (related to short-chain alcohol dehydrogenases) YP_002472577.1 homology (Evalue<1e-4) to COG1533 [L] DNA repair photolyase YP_002472580.1 catalyzes the first step in pyrimidine degradation: the NADPH-dependent reduction of uracil and thymine to the corresponding 5,6-dihydropyrimidines YP_002472581.1 homology (Evalue<1e-4) to COG0493 [ER] NADPH-dependent glutamate synthase beta chain and related oxidoreductases YP_002472582.1 homology (Evalue<1e-4) to COG0044 [F] Dihydroorotase and related cyclic amidohydrolases YP_002472583.1 homology (Evalue<1e-4) to COG1953 [FH] Cytosine/uracil/thiamine/allantoin permeases YP_002472584.1 allantoate amidohydrolase and N-carbamoyl-L-amino acid amidohydrolase are very similar; the allantoate amidohydrolase from Escherichia coli forms a dimer and binds zinc ions for catalytic activity and catalyzes the conversion of allantoate to (S)-ureidoglycolate and ammonia; carbamoyl amidohydrolase from Bacillus sp. converts N-carbamoyl amino acids to amino acids, ammonia, and carbon dioxide YP_002472585.1 homology (Evalue<1e-4) to COG0160 [E] PLP-dependent aminotransferases YP_002472586.1 homology (Evalue<1e-4) to COG1454 [C] Alcohol dehydrogenase IV YP_002472587.1 homology (Evalue<1e-4) to COG2508 [TQ] Regulator of polyketide synthase expression YP_002472588.1 homology (Evalue<1e-4) to COG0010 [E] Arginase/agmatinase/formimionoglutamate hydrolase, arginase family YP_002472589.1 homology (Evalue<1e-4) to COG0281 [C] Malic enzyme YP_002472590.1 homology (Evalue<1e-4) to COG0477 [GEPR] Permeases of the major facilitator superfamily YP_002472592.1 member of metallo-beta-lactamase family; the purified enzyme from Escherichia coli forms dimeric zinc phosphodiesterase; in Bacillus subtilis this protein is a 3'-tRNA processing endoribonuclease and is essential while in Escherichia coli it is not; associates with two zinc ions YP_002472593.1 homology (Evalue<1e-4) to COG0840 [N] Methyl-accepting chemotaxis protein YP_002472594.1 with PdxST is involved in the biosynthesis of pyridoxal 5'-phosphate; PdxT catalyzes the hydrolysis of glutamine to glutamate and ammonia; PdxS utilizes the ammonia to synthesize pyridoxal 5'-phosphate YP_002472595.1 with PdxT forms pyridoxal 5'-phosphate from glutamine, either ribose 5-phosphate or ribulose 5-phosphate, and either glyceraldehyde 3-phosphate or dihydroxyacetone phosphate YP_002472596.1 homology (Evalue<1e-4) to COG1524 [R] Uncharacterized proteins of the AP superfamily YP_002472597.1 homology (Evalue<1e-4) to COG0340 [H] Biotin-(acetyl-CoA carboxylase) ligase YP_002472598.1 homology (Evalue<1e-4) to COG0044 [F] Dihydroorotase and related cyclic amidohydrolases YP_002472599.1 homology (Evalue<1e-4) to COG1145 [C] Ferredoxin 2 YP_002472600.1 homology (Evalue<1e-4) to COG0664 [T] cAMP-binding domains - Catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases YP_002472601.1 homology (Evalue<1e-4) to COG2968 [S] Uncharacterized BCR YP_002472602.1 homology (Evalue<1e-4) to COG0617 [J] tRNA nucleotidyltransferase/poly(A) polymerase YP_002472603.1 homology (Evalue<1e-4) to COG0739 [M] Membrane proteins related to metalloendopeptidases YP_002472605.1 homology (Evalue<1e-4) to COG0463 [M] Glycosyltransferases involved in cell wall biogenesis YP_002472606.1 homology (Evalue<1e-4) to COG2931 [Q] RTX toxins and related Ca2+-binding proteins YP_002472607.1 homology (Evalue<1e-4) to COG1846 [K] Transcriptional regulators YP_002472608.1 homology (Evalue<1e-4) to COG0477 [GEPR] Permeases of the major facilitator superfamily YP_002472609.1 homology (Evalue<1e-4) to COG1321 [K] Mn-dependent transcriptional regulator YP_002472611.1 homology (Evalue<1e-4) to COG0500 [QR] SAM-dependent methyltransferases YP_002472612.1 homology (Evalue<1e-4) to COG0393 [S] Uncharacterized ACR YP_002472613.1 this stereospecific enzymes reduces the R isomer of methionine sulfoxide while MsrA reduces the S form; provides protection against oxidative stress YP_002472615.1 homology (Evalue<1e-4) to COG0789 [K] Predicted transcriptional regulators YP_002472616.1 homology (Evalue<1e-4) to COG0745 [TK] Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain YP_002472617.1 homology (Evalue<1e-4) to COG0642 [T] Signal transduction histidine kinase YP_002472619.1 homology (Evalue<1e-4) to COG1131 [Q] ABC-type multidrug transport system, ATPase component YP_002472620.1 homology (Evalue<1e-4) to COG0842 [R] ABC-type multidrug transport system, permease component YP_002472621.1 homology (Evalue<1e-4) to COG1846 [K] Transcriptional regulators YP_002472622.1 catalyzes the reduction of hydroxylamine to ammonia and water YP_002472624.1 homology (Evalue<1e-4) to COG1704 [S] Uncharacterized ACR YP_002472625.1 homology (Evalue<1e-4) to COG1132 [Q] ABC-type multidrug/protein/lipid transport system, ATPase component YP_002472626.1 homology (Evalue<1e-4) to COG1132 [Q] ABC-type multidrug/protein/lipid transport system, ATPase component YP_002472627.1 homology (Evalue<1e-4) to COG2207 [K] AraC-type DNA-binding domain-containing proteins YP_002472628.1 homology (Evalue<1e-4) to COG1741 [R] Pirin-related protein YP_002472629.1 homology (Evalue<1e-4) to COG0655 [R] Multimeric flavodoxin WrbA YP_002472630.1 homology (Evalue<1e-4) to COG3689 [S] Predicted membrane protein YP_002472631.1 homology (Evalue<1e-4) to COG0701 [R] Predicted permeases YP_002472632.1 homology (Evalue<1e-4) to COG0523 [R] GTPases (G3E family) YP_002472633.1 homology (Evalue<1e-4) to COG0569 [P] K+ transport systems, NAD-binding component YP_002472634.1 homology (Evalue<1e-4) to COG0168 [P] Trk-type K+ transport systems, membrane components YP_002472635.1 homology (Evalue<1e-4) to COG1902 [C] NADH:flavin oxidoreductases, Old Yellow Enzyme family YP_002472636.1 homology (Evalue<1e-4) to COG3044 [R] Predicted ATPase of the ABC class YP_002472637.1 homology (Evalue<1e-4) to COG3738 [S] Uncharacterized BCR YP_002472638.1 homology (Evalue<1e-4) to COG2710 [C] Nitrogenase molybdenum-iron protein, alpha and beta chains YP_002472639.1 homology (Evalue<1e-4) to COG2710 [C] Nitrogenase molybdenum-iron protein, alpha and beta chains YP_002472640.1 homology (Evalue<1e-4) to COG1348 [P] Nitrogenase subunit NifH (ATPase) YP_002472641.1 homology (Evalue<1e-4) to COG2207 [K] AraC-type DNA-binding domain-containing proteins YP_002472642.1 homology (Evalue<1e-4) to COG2076 [P] Membrane transporters of cations and cationic drugs YP_002472643.1 homology (Evalue<1e-4) to COG0477 [GEPR] Permeases of the major facilitator superfamily YP_002472645.1 homology (Evalue<1e-4) to COG1083 [M] CMP-N-acetylneuraminic acid synthetase YP_002472647.1 homology (Evalue<1e-4) to COG0399 [M] Predicted pyridoxal phosphate-dependent enzyme apparently involved in regulation of cell wall biogenesis YP_002472648.1 homology (Evalue<1e-4) to COG2120 [S] Uncharacterized proteins, LmbE homologs YP_002472649.1 homology (Evalue<1e-4) to COG0381 [M] UDP-N-acetylglucosamine 2-epimerase YP_002472651.1 homology (Evalue<1e-4) to COG2089 [M] Sialic acid synthase YP_002472652.1 homology (Evalue<1e-4) to COG0110 [R] Acetyltransferases (the isoleucine patch superfamily) YP_002472653.1 homology (Evalue<1e-4) to COG0451 [MG] Nucleoside-diphosphate-sugar epimerases YP_002472656.1 homology (Evalue<1e-4) to COG2604 [S] Uncharacterized BCR YP_002472659.1 homology (Evalue<1e-4) to COG2230 [M] Cyclopropane fatty acid synthase and related methyltransferases YP_002472660.1 homology (Evalue<1e-4) to COG0789 [K] Predicted transcriptional regulators YP_002472661.1 homology (Evalue<1e-4) to COG0840 [N] Methyl-accepting chemotaxis protein YP_002472662.1 homology (Evalue<1e-4) to COG0840 [N] Methyl-accepting chemotaxis protein YP_002472663.1 homology (Evalue<1e-4) to COG1277 [R] ABC-type transport system involved in multi-copper enzyme maturation, permease component YP_002472664.1 homology (Evalue<1e-4) to COG1131 [Q] ABC-type multidrug transport system, ATPase component YP_002472666.1 homology (Evalue<1e-4) to COG1396 [K] Predicted transcriptional regulators YP_002472667.1 homology (Evalue<1e-4) to COG0842 [R] ABC-type multidrug transport system, permease component YP_002472668.1 homology (Evalue<1e-4) to COG1131 [Q] ABC-type multidrug transport system, ATPase component YP_002472669.1 homology (Evalue<1e-4) to COG1309 [K] Transcriptional regulator YP_002472670.1 homology (Evalue<1e-4) to COG1309 [K] Transcriptional regulator YP_002472671.1 homology (Evalue<1e-4) to COG0477 [GEPR] Permeases of the major facilitator superfamily YP_002472672.1 homology (Evalue<1e-4) to COG1335 [Q] Amidases related to nicotinamidase YP_002472673.1 homology (Evalue<1e-4) to COG1122 [P] ABC-type cobalt transport system, ATPase component YP_002472674.1 homology (Evalue<1e-4) to COG0619 [P] ABC-type cobalt transport system, permease component CbiQ and related transporters YP_002472675.1 catalyzes the ATP-dependent transport of cobalt YP_002472676.1 homology (Evalue<1e-4) to COG0421 [E] Spermidine synthase YP_002472677.1 homology (Evalue<1e-4) to COG1606 [R] ATP-utilizing enzymes of the PP-loop superfamily YP_002472678.1 homology (Evalue<1e-4) to COG0789 [K] Predicted transcriptional regulators YP_002472679.1 homology (Evalue<1e-4) to COG0599 [S] Uncharacterized ACR, homolog of gamma-carboxymuconolactone decarboxylase subunit YP_002472680.1 homology (Evalue<1e-4) to COG3070 [N] Regulator of competence-specific genes YP_002472681.1 homology (Evalue<1e-4) to COG0614 [P] ABC-type cobalamin/Fe3+-siderophores transport systems, periplasmic components YP_002472682.1 homology (Evalue<1e-4) to COG0614 [P] ABC-type cobalamin/Fe3+-siderophores transport systems, periplasmic components YP_002472683.1 homology (Evalue<1e-4) to COG1120 [PH] ABC-type cobalamin/Fe3+-siderophores transport systems, ATPase components YP_002472684.1 homology (Evalue<1e-4) to COG0609 [PH] ABC-type cobalamin/Fe3+-siderophores transport systems, permease components YP_002472685.1 homology (Evalue<1e-4) to COG2710 [C] Nitrogenase molybdenum-iron protein, alpha and beta chains YP_002472686.1 homology (Evalue<1e-4) to COG2710 [C] Nitrogenase molybdenum-iron protein, alpha and beta chains YP_002472687.1 homology (Evalue<1e-4) to COG0707 [M] UDP-N-acetylglucosamine:LPS N-acetylglucosamine transferase YP_002472689.1 homology (Evalue<1e-4) to COG1307 [S] Uncharacterized BCR YP_002472690.1 homology (Evalue<1e-4) to COG0716 [C] Flavodoxins YP_002472692.1 homology (Evalue<1e-4) to COG1309 [K] Transcriptional regulator YP_002472693.1 homology (Evalue<1e-4) to COG0477 [GEPR] Permeases of the major facilitator superfamily YP_002472697.1 homology (Evalue<1e-4) to COG1846 [K] Transcriptional regulators YP_002472698.1 homology (Evalue<1e-4) to COG2801 [L] transposase YP_002472699.1 homology (Evalue<1e-4) to COG2801 [L] transposase YP_002472700.1 homology (Evalue<1e-4) to COG2186 [K] Transcriptional regulators YP_002472701.1 homology (Evalue<1e-4) to COG1346 [M] effector of murein hydrolase YP_002472702.1 homology (Evalue<1e-4) to COG1380 [R] effector of murein hydrolase LrgA YP_002472703.1 homology (Evalue<1e-4) to COG1024 [I] Enoyl-CoA hydratase/carnithine racemase YP_002472705.1 homology (Evalue<1e-4) to COG0210 [L] Superfamily I DNA and RNA helicases YP_002472706.1 homology (Evalue<1e-4) to COG1309 [K] Transcriptional regulator YP_002472709.1 homology (Evalue<1e-4) to COG0394 [T] Protein-tyrosine-phosphatase YP_002472710.1 homology (Evalue<1e-4) to COG0798 [P] Arsenite efflux pump ACR3 and related permeases YP_002472711.1 homology (Evalue<1e-4) to COG0640 [K] Predicted transcriptional regulators YP_002472712.1 homology (Evalue<1e-4) to COG0110 [R] Acetyltransferases (the isoleucine patch superfamily) YP_002472713.1 homology (Evalue<1e-4) to COG0488 [R] ATPase components of ABC transporters with duplicated ATPase domains YP_002472714.1 homology (Evalue<1e-4) to COG2801 [L] transposase YP_002472715.1 homology (Evalue<1e-4) to COG2801 [L] transposase YP_002472718.1 homology (Evalue<1e-4) to COG1695 [K] Predicted transcriptional regulators YP_002472720.1 homology (Evalue<1e-4) to COG2159 [R] Predicted metal-dependent hydrolase of the TIM-barrel fold YP_002472721.1 homology (Evalue<1e-4) to COG1228 [Q] Imidazolonepropionase and related amidohydrolases YP_002472722.1 homology (Evalue<1e-4) to COG0642 [T] Signal transduction histidine kinase YP_002472723.1 homology (Evalue<1e-4) to COG0745 [TK] Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain YP_002472724.1 homology (Evalue<1e-4) to COG1846 [K] Transcriptional regulators YP_002472727.1 homology (Evalue<1e-4) to COG0491 [R] Zn-dependent hydrolases, including glyoxylases YP_002472728.1 homology (Evalue<1e-4) to COG2382 [P] Enterochelin esterase and related enzymes YP_002472729.1 homology (Evalue<1e-4) to COG0778 [C] Nitroreductase YP_002472732.1 homology (Evalue<1e-4) to COG1061 [L] DNA or RNA helicases of superfamily II YP_002472734.1 homology (Evalue<1e-4) to COG1952 [N] Preprotein translocase subunit SecB YP_002472737.1 homology (Evalue<1e-4) to COG3587 [L] Restriction endonuclease YP_002472738.1 homology (Evalue<1e-4) to COG3587 [L] Restriction endonuclease YP_002472739.1 homology (Evalue<1e-4) to COG3655 [K] Predicted transcriptional regulator YP_002472742.1 homology (Evalue<1e-4) to COG0574 [G] Phosphoenolpyruvate synthase/pyruvate phosphate dikinase YP_002472743.1 homology (Evalue<1e-4) to COG0574 [G] Phosphoenolpyruvate synthase/pyruvate phosphate dikinase YP_002472744.1 homology (Evalue<1e-4) to COG1309 [K] Transcriptional regulator YP_002472745.1 homology (Evalue<1e-4) to COG1902 [C] NADH:flavin oxidoreductases, Old Yellow Enzyme family YP_002472746.1 homology (Evalue<1e-4) to COG1145 [C] Ferredoxin 2 YP_002472747.1 homology (Evalue<1e-4) to COG0300 [R] Short-chain dehydrogenases of various substrate specificities YP_002472749.1 homology (Evalue<1e-4) to COG1032 [C] Fe-S oxidoreductases family 2 YP_002472750.1 homology (Evalue<1e-4) to COG1145 [C] Ferredoxin 2 YP_002472751.1 homology (Evalue<1e-4) to COG0300 [R] Short-chain dehydrogenases of various substrate specificities YP_002472752.1 homology (Evalue<1e-4) to COG1511 [S] Predicted membrane protein YP_002472753.1 homology (Evalue<1e-4) to COG1033 [R] Predicted exporters of the RND superfamily YP_002472754.1 homology (Evalue<1e-4) to COG0657 [I] Esterase/lipase YP_002472755.1 homology (Evalue<1e-4) to COG3829 [KT] Transcriptional regulator containing PAS, AAA-type ATPase, and DNA-binding domains YP_002472756.1 homology (Evalue<1e-4) to COG2108 [R] Uncharacterized ACR related to pyruvate formate-lyase activating enzyme YP_002472758.1 homology (Evalue<1e-4) to COG1846 [K] Transcriptional regulators YP_002472760.1 homology (Evalue<1e-4) to COG0477 [GEPR] Permeases of the major facilitator superfamily YP_002472765.1 homology (Evalue<1e-4) to COG0582 [L] Integrase YP_002472766.1 homology (Evalue<1e-4) to COG0732 [L] Restriction endonuclease S subunits YP_002472767.1 homology (Evalue<1e-4) to COG0610 [L] Restriction enzymes type I helicase subunits and related helicases YP_002472768.1 homology (Evalue<1e-4) to COG0827 [L] Adenine-specific DNA methylase YP_002472770.1 homology (Evalue<1e-4) to COG0491 [R] Zn-dependent hydrolases, including glyoxylases YP_002472774.1 homology (Evalue<1e-4) to COG0500 [QR] SAM-dependent methyltransferases YP_002472777.1 homology (Evalue<1e-4) to COG1136 [R] ABC-type transport systems, involved in lipoprotein release, ATPase components YP_002472778.1 homology (Evalue<1e-4) to COG0642 [T] Signal transduction histidine kinase YP_002472779.1 homology (Evalue<1e-4) to COG0745 [TK] Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain YP_002472781.1 homology (Evalue<1e-4) to COG2320 [S] Uncharacterized ACR YP_002472782.1 homology (Evalue<1e-4) to COG0500 [QR] SAM-dependent methyltransferases YP_002472784.1 homology (Evalue<1e-4) to COG0488 [R] ATPase components of ABC transporters with duplicated ATPase domains YP_002472785.1 homology (Evalue<1e-4) to COG0477 [GEPR] Permeases of the major facilitator superfamily YP_002472786.1 homology (Evalue<1e-4) to COG1961 [L] Site-specific recombinases, DNA invertase Pin homologs YP_002472788.1 homology (Evalue<1e-4) to COG1961 [L] Site-specific recombinases, DNA invertase Pin homologs YP_002472792.1 homology (Evalue<1e-4) to COG2931 [Q] RTX toxins and related Ca2+-binding proteins YP_002472806.1 homology (Evalue<1e-4) to COG0740 [NO] Protease subunit of ATP-dependent Clp proteases YP_002472812.1 homology (Evalue<1e-4) to COG0863 [L] DNA modification methylase YP_002472813.1 catalyzes the formation of S-adenosylmethionine from methionine and ATP; methionine adenosyltransferase YP_002472815.1 homology (Evalue<1e-4) to COG1403 [L] Restriction endonuclease YP_002472816.1 homology (Evalue<1e-4) to COG1476 [K] Predicted transcriptional regulators YP_002472817.1 homology (Evalue<1e-4) to COG0242 [J] N-formylmethionyl-tRNA deformylase YP_002472819.1 homology (Evalue<1e-4) to COG0553 [KL] Superfamily II DNA/RNA helicases, SNF2 family YP_002472823.1 homology (Evalue<1e-4) to COG3561 [K] Phage anti-repressor protein YP_002472824.1 homology (Evalue<1e-4) to COG0749 [L] DNA polymerase I - 3'-5' exonuclease and polymerase domains YP_002472830.1 homology (Evalue<1e-4) to COG1396 [K] Predicted transcriptional regulators YP_002472832.1 homology (Evalue<1e-4) to COG0270 [L] Site-specific DNA methylase YP_002472833.1 homology (Evalue<1e-4) to COG2265 [J] SAM-dependent methyltransferases related to tRNA (uracil-5-)-methyltransferase YP_002472834.1 homology (Evalue<1e-4) to COG0724 [K] RNA-binding proteins (RRM domain) YP_002472835.1 homology (Evalue<1e-4) to COG1368 [M] Phosphoglycerol transferase and related proteins, alkaline phosphatase superfamily YP_002472836.1 homology (Evalue<1e-4) to COG2801 [L] transposase YP_002472837.1 homology (Evalue<1e-4) to COG2801 [L] transposase YP_002472838.1 homology (Evalue<1e-4) to COG1368 [M] Phosphoglycerol transferase and related proteins, alkaline phosphatase superfamily YP_002472839.1 homology (Evalue<1e-4) to COG0084 [L] Mg-dependent DNase YP_002472841.1 homology (Evalue<1e-4) to COG0491 [R] Zn-dependent hydrolases, including glyoxylases YP_002472844.1 catalyzes the formation of N(1)-(5-phospho-D-ribosyl)glycinamide from 5-phospho-D-ribosylamine and glycine in purine biosynthesis YP_002472845.1 involved in de novo purine biosynthesis YP_002472846.1 glycinamide ribonucleotide transformylase; GAR Tfase; catalyzes the synthesis of 5'-phosphoribosylformylglycinamide from 5'-phosphoribosylglycinamide and 10-formyltetrahydrofolate; PurN requires formyl folate for the reaction unlike PurT which uses formate YP_002472847.1 catalyzes the formation of 1-(5-phosphoribosyl)-5-aminoimidazole from 2-(formamido)-N1-(5-phosphoribosyl)acetamidine and ATP in purine biosynthesis YP_002472848.1 Catalyzes first step of the de novo purine nucleotide biosynthetic pathway YP_002472849.1 catalyzes the formation of (S)-2-(5-amino-1-(5-phospho-D-ribosyl)imidazole-4- carboxamido)succinate from 5-amino-1-(5-phospho-D-ribosyl)imidazole-4-carboxylate and L-aspartate in purine biosynthesis; SAICAR synthase YP_002472850.1 homology (Evalue<1e-4) to COG0041 [F] Phosphoribosylcarboxyaminoimidazole (NCAIR) mutase YP_002472851.1 homology (Evalue<1e-4) to COG2755 [E] Lysophospholipase L1 and related esterases YP_002472852.1 homology (Evalue<1e-4) to COG1434 [S] Uncharacterized ACR YP_002472853.1 homology (Evalue<1e-4) to COG2252 [R] Permeases YP_002472854.1 homology (Evalue<1e-4) to COG1002 [L] Type II restriction enzyme, methylase subunits YP_002472855.1 homology (Evalue<1e-4) to COG0534 [Q] Na+-driven multidrug efflux pump YP_002472856.1 homology (Evalue<1e-4) to COG0265 [O] Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain YP_002472857.1 transfers the N-acyl diglyceride moiety to the prospective N-terminal cysteine in prolipoprotein YP_002472858.1 homology (Evalue<1e-4) to COG1968 [S] Uncharacterized ACR, bacitracin resistance protein YP_002472859.1 PEP carboxykinase; PEP carboxylase; PEPCK; catalyzes the phosphorylation and decarboxylation of oxaloacetate to form phosphoenolpyruvate using ATP YP_002472860.1 homology (Evalue<1e-4) to COG0769 [M] UDP-N-acetylmuramyl tripeptide synthase YP_002472861.1 homology (Evalue<1e-4) to COG3442 [R] Predicted glutamine amidotransferase YP_002472862.1 homology (Evalue<1e-4) to COG0542 [O] ATPases with chaperone activity, ATP-binding subunit YP_002472863.1 homology (Evalue<1e-4) to COG0457 [R] TPR-repeat-containing proteins YP_002472864.1 homology (Evalue<1e-4) to COG0457 [R] TPR-repeat-containing proteins YP_002472865.1 homology (Evalue<1e-4) to COG1878 [R] Uncharacterized ACR, predicted metal-dependent hydrolases YP_002472867.1 homology (Evalue<1e-4) to COG2364 [R] Uncharacterized membrane protein YP_002472868.1 homology (Evalue<1e-4) to COG3595 [S] Uncharacterized BCR YP_002472870.1 homology (Evalue<1e-4) to COG1695 [K] Predicted transcriptional regulators YP_002472877.1 homology (Evalue<1e-4) to COG1595 [K] DNA-directed RNA polymerase specialized sigma subunits, sigma24 homologs YP_002472878.1 homology (Evalue<1e-4) to COG2217 [P] Cation transport ATPases YP_002472879.1 homology (Evalue<1e-4) to COG1937 [S] Uncharacterized BCR YP_002472880.1 homology (Evalue<1e-4) to COG0465 [O] ATP-dependent Zn proteases YP_002472881.1 homology (Evalue<1e-4) to COG0705 [R] Uncharacterized membrane protein (homolog of Drosophila rhomboid) YP_002472882.1 homology (Evalue<1e-4) to COG2206 [T] HD-GYP domain YP_002472884.1 homology (Evalue<1e-4) to COG0735 [P] Fe2+/Zn2+ uptake regulation proteins YP_002472885.1 homology (Evalue<1e-4) to COG1971 [S] Predicted membrane protein YP_002472886.1 homology (Evalue<1e-4) to COG1451 [R] Predicted metal-dependent hydrolase YP_002472887.1 homology (Evalue<1e-4) to COG0793 [M] Periplasmic protease YP_002472888.1 homology (Evalue<1e-4) to COG2247 [M] cell wall-binding domain YP_002472889.1 homology (Evalue<1e-4) to COG1846 [K] Transcriptional regulators YP_002472890.1 homology (Evalue<1e-4) to COG1335 [Q] Amidases related to nicotinamidase YP_002472891.1 homology (Evalue<1e-4) to COG0768 [M] Cell division protein FtsI/penicillin-binding protein 2 YP_002472892.1 homology (Evalue<1e-4) to COG0840 [N] Methyl-accepting chemotaxis protein YP_002472893.1 homology (Evalue<1e-4) to COG2008 [E] Threonine aldolase YP_002472894.1 Catalyzes the phosphorylation of L-glutamate during the proline biosynthesis pathway YP_002472895.1 homology (Evalue<1e-4) to COG0263 [E] Glutamate 5-kinase YP_002472896.1 homology (Evalue<1e-4) to COG0345 [E] Pyrroline-5-carboxylate reductase YP_002472897.1 homology (Evalue<1e-4) to COG0038 [P] Chloride channel protein EriC YP_002472898.1 homology (Evalue<1e-4) to COG0683 [E] ABC-type branched-chain amino acid transport systems, periplasmic component YP_002472899.1 homology (Evalue<1e-4) to COG0410 [E] ABC-type branched-chain amino acid transport systems, ATPase component YP_002472900.1 homology (Evalue<1e-4) to COG0411 [E] ABC-type branched-chain amino acid transport systems, ATPase component YP_002472901.1 homology (Evalue<1e-4) to COG0559 [E] Branched-chain amino acid ABC-type transport system, permease components YP_002472902.1 homology (Evalue<1e-4) to COG0559 [E] Branched-chain amino acid ABC-type transport system, permease components YP_002472903.1 homology (Evalue<1e-4) to COG3585 [H] Molybdopterin-binding protein YP_002472904.1 homology (Evalue<1e-4) to COG0242 [J] N-formylmethionyl-tRNA deformylase YP_002472905.1 homology (Evalue<1e-4) to COG1476 [K] Predicted transcriptional regulators YP_002472906.1 homology (Evalue<1e-4) to COG2755 [E] Lysophospholipase L1 and related esterases YP_002472907.1 homology (Evalue<1e-4) to COG2801 [L] transposase YP_002472908.1 homology (Evalue<1e-4) to COG2801 [L] transposase YP_002472909.1 homology (Evalue<1e-4) to COG1343 [S] Uncharacterized ACR YP_002472910.1 homology (Evalue<1e-4) to COG1518 [S] Uncharacterized ACR YP_002472911.1 homology (Evalue<1e-4) to COG1468 [L] RecB family exonuclease YP_002472912.1 homology (Evalue<1e-4) to COG1203 [R] Predicted helicases YP_002472913.1 homology (Evalue<1e-4) to COG1688 [S] Uncharacterized ACR YP_002472914.1 homology (Evalue<1e-4) to COG3649 [S] Uncharacterized BCR YP_002472916.1 homology (Evalue<1e-4) to COG1583 [S] Uncharacterized ACR YP_002472917.1 homology (Evalue<1e-4) to COG2865 [K] Predicted transcriptional regulator containing an HTH domain and an uncharacterized domain shared with the mammalian protein Schlafen YP_002472918.1 homology (Evalue<1e-4) to COG2962 [R] Predicted permeases YP_002472919.1 homology (Evalue<1e-4) to COG0789 [K] Predicted transcriptional regulators YP_002472921.1 homology (Evalue<1e-4) to COG0531 [E] Amino acid transporters YP_002472925.1 homology (Evalue<1e-4) to COG2055 [C] Malate/L-lactate dehydrogenases YP_002472926.1 homology (Evalue<1e-4) to COG2110 [S] Uncharacterized ACR related to the C-terminal domain of histone macroH2A1 YP_002472927.1 homology (Evalue<1e-4) to COG0605 [P] Superoxide dismutase YP_002472928.1 homology (Evalue<1e-4) to COG1177 [E] ABC-type spermidine/putrescine transport system, permease component II YP_002472929.1 homology (Evalue<1e-4) to COG1176 [E] ABC-type spermidine/putrescine transport system, permease component I YP_002472930.1 homology (Evalue<1e-4) to COG0687 [E] Spermidine/putrescine-binding periplasmic protein YP_002472931.1 homology (Evalue<1e-4) to COG3842 [E] ABC-type spermidine/putrescine transport systems, ATPase components YP_002472934.1 homology (Evalue<1e-4) to COG0274 [F] Deoxyribose-phosphate aldolase YP_002472935.1 homology (Evalue<1e-4) to COG0715 [P] ABC-type nitrate/sulfonate/taurine/bicarbonate transport systems, periplasmic components YP_002472936.1 homology (Evalue<1e-4) to COG0600 [P] ABC-type nitrate/sulfonate/taurine/bicarbonate transport systems, permease components YP_002472938.1 homology (Evalue<1e-4) to COG2710 [C] Nitrogenase molybdenum-iron protein, alpha and beta chains YP_002472939.1 homology (Evalue<1e-4) to COG0535 [R] Predicted Fe-S oxidoreductases YP_002472941.1 homology (Evalue<1e-4) to COG2710 [C] Nitrogenase molybdenum-iron protein, alpha and beta chains YP_002472943.1 homology (Evalue<1e-4) to COG0840 [N] Methyl-accepting chemotaxis protein YP_002472944.1 homology (Evalue<1e-4) to COG1984 [E] Allophanate hydrolase subunit 2 YP_002472945.1 homology (Evalue<1e-4) to COG2049 [E] Allophanate hydrolase subunit 1 YP_002472946.1 homology (Evalue<1e-4) to COG1540 [R] Uncharacterized proteins, homologs of lactam utilization protein B YP_002472947.1 homology (Evalue<1e-4) to COG0024 [J] Methionine aminopeptidase YP_002472948.1 homology (Evalue<1e-4) to COG1853 [R] Conserved protein/domain typically associated with flavoprotein oxygenases, DIM6/NTAB family YP_002472949.1 homology (Evalue<1e-4) to COG0861 [P] Membrane protein TerC, possibly involved in tellurium resistance YP_002472950.1 homology (Evalue<1e-4) to COG0180 [J] Tryptophanyl-tRNA synthetase YP_002472951.1 homology (Evalue<1e-4) to COG1250 [I] 3-Hydroxyacyl-CoA dehydrogenase YP_002472952.1 homology (Evalue<1e-4) to COG1732 [M] Periplasmic glycine betaine/choline-binding (lipo)protein of an ABC-type transport system (osmoprotectant binding protein) YP_002472953.1 homology (Evalue<1e-4) to COG1125 [E] ABC-type proline/glycine betaine transport systems, ATPase components YP_002472954.1 homology (Evalue<1e-4) to COG2188 [K] Transcriptional regulators YP_002472955.1 homology (Evalue<1e-4) to COG0289 [E] Dihydrodipicolinate reductase YP_002472960.1 homology (Evalue<1e-4) to COG3279 [KT] Response regulator of the LytR/AlgR family YP_002472962.1 homology (Evalue<1e-4) to COG2972 [T] Predicted signal transduction protein with a C-terminal ATPase domain YP_002472963.1 homology (Evalue<1e-4) to COG0071 [O] Molecular chaperone (small heat shock protein) YP_002472964.1 homology (Evalue<1e-4) to COG0249 [L] MutS-like ATPases involved in mismatch repair, family 2 YP_002472965.1 homology (Evalue<1e-4) to COG0432 [S] Uncharacterized ACR YP_002472966.1 homology (Evalue<1e-4) to COG3341 [R] Predicted double-stranded RNA/RNA-DNA hybrid binding protein YP_002472967.1 tRNA (guanine-N(7)-)-methyltransferase; catalyzes the formation of N(7)-methylguanine at position 46 (m7G46) in tRNA by transferring the methyl residue from S-adenosyl-L-methionine YP_002472969.1 homology (Evalue<1e-4) to COG1994 [R] Zn-dependent proteases YP_002472972.1 homology (Evalue<1e-4) to COG1875 [T] Predicted ATPase related to phosphate starvation-inducible protein PhoH YP_002472973.1 homology (Evalue<1e-4) to COG1131 [Q] ABC-type multidrug transport system, ATPase component YP_002472975.1 homology (Evalue<1e-4) to COG1388 [N] LysM-repeat proteins and domains YP_002472976.1 homology (Evalue<1e-4) to COG1811 [R] Uncharacterized membrane protein, possible Na+ channel or pump YP_002472977.1 homology (Evalue<1e-4) to COG0840 [N] Methyl-accepting chemotaxis protein YP_002472978.1 homology (Evalue<1e-4) to COG2200 [T] EAL domain YP_002472979.1 homology (Evalue<1e-4) to COG1687 [E] Predicted branched-chain amino acid permeases (azaleucine resistance) YP_002472980.1 homology (Evalue<1e-4) to COG1296 [E] Predicted branched-chain amino acid permease (azaleucine resistance) YP_002472981.1 homology (Evalue<1e-4) to COG1396 [K] Predicted transcriptional regulators YP_002472982.1 An electron-transfer protein; flavodoxin binds one FMN molecule, which serves as a redox-active prosthetic group YP_002472983.1 homology (Evalue<1e-4) to COG1853 [R] Conserved protein/domain typically associated with flavoprotein oxygenases, DIM6/NTAB family YP_002472985.1 homology (Evalue<1e-4) to COG1396 [K] Predicted transcriptional regulators YP_002472986.1 homology (Evalue<1e-4) to COG3757 [M] Lyzozyme M1 (1,4-beta-N-acetylmuramidase) YP_002472990.1 homology (Evalue<1e-4) to COG1237 [R] Metal-dependent hydrolases of the beta-lactamase superfamily II YP_002472991.1 homology (Evalue<1e-4) to COG2230 [M] Cyclopropane fatty acid synthase and related methyltransferases YP_002472992.1 homology (Evalue<1e-4) to COG1253 [N] Hemolysins and related proteins containing CBS domains YP_002472994.1 homology (Evalue<1e-4) to COG0194 [F] Guanylate kinase YP_002472995.1 homology (Evalue<1e-4) to COG3212 [S] Uncharacterized membrane protein YP_002473001.1 homology (Evalue<1e-4) to COG1309 [K] Transcriptional regulator YP_002473002.1 homology (Evalue<1e-4) to COG0477 [GEPR] Permeases of the major facilitator superfamily YP_002473003.1 homology (Evalue<1e-4) to COG0681 [N] Signal peptidase I YP_002473004.1 homology (Evalue<1e-4) to COG1942 [R] Uncharacterized protein, 4-oxalocrotonate tautomerase homolog YP_002473009.1 homology (Evalue<1e-4) to COG1961 [L] Site-specific recombinases, DNA invertase Pin homologs YP_002473012.1 homology (Evalue<1e-4) to COG1396 [K] Predicted transcriptional regulators YP_002473014.1 homology (Evalue<1e-4) to COG1943 [L] Predicted transposase YP_002473015.1 homology (Evalue<1e-4) to COG1961 [L] Site-specific recombinases, DNA invertase Pin homologs YP_002473016.1 homology (Evalue<1e-4) to COG2801 [L] transposase YP_002473018.1 homology (Evalue<1e-4) to COG1309 [K] Transcriptional regulator YP_002473021.1 homology (Evalue<1e-4) to COG2247 [M] cell wall-binding domain YP_002473022.1 homology (Evalue<1e-4) to COG1619 [S] Uncharacterized proteins, homologs of microcin C7 resistance protein MccF YP_002473023.1 homology (Evalue<1e-4) to COG1278 [K] Cold shock proteins YP_002473024.1 homology (Evalue<1e-4) to COG1846 [K] Transcriptional regulators YP_002473025.1 homology (Evalue<1e-4) to COG0477 [GEPR] Permeases of the major facilitator superfamily YP_002473026.1 homology (Evalue<1e-4) to COG2032 [P] Cu/Zn superoxide dismutase YP_002473028.1 homology (Evalue<1e-4) to COG0655 [R] Multimeric flavodoxin WrbA YP_002473030.1 homology (Evalue<1e-4) to COG1278 [K] Cold shock proteins YP_002473033.1 homology (Evalue<1e-4) to COG3545 [R] Predicted esterase of the alpha/beta hydrolase fold YP_002473035.1 homology (Evalue<1e-4) to COG3728 [L] Phage terminase, small subunit YP_002473037.1 homology (Evalue<1e-4) to COG2367 [M] Beta-lactamase class A YP_002473038.1 homology (Evalue<1e-4) to COG3316 [L] transposase YP_002473040.1 homology (Evalue<1e-4) to COG1121 [P] ABC-type Mn/Zn transport systems, ATPase component YP_002473041.1 homology (Evalue<1e-4) to COG1108 [P] ABC-type Mn2+/Zn2+ transport systems, permease components YP_002473043.1 catalyzes the synthesis of alpha-ribazole-5'-phosphate from nicotinate mononucleotide and 5,6-dimethylbenzimidazole YP_002473044.1 catalyzes the formation of siroheme from precorrin-2 YP_002473045.1 CobD; CbiD in Salmonella; converts cobyric acid to cobinamide by the addition of aminopropanol on the F carboxylic group YP_002473046.1 homology (Evalue<1e-4) to COG0494 [LR] NTP pyrophosphohydrolases including oxidative damage repair enzymes YP_002473047.1 homology (Evalue<1e-4) to COG1167 [KE] Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain (MocR family) and their eukaryotic orthologs YP_002473048.1 homology (Evalue<1e-4) to COG1464 [R] ABC-type uncharacterized transport systems, periplasmic component YP_002473049.1 D-alanine--D-alanine ligase; DdlA; DdlB; cytoplasmic; catalyzes the formation of D-alanyl-D-alanine from two D-alanines in peptidoglycan synthesis; there are two forms of this enzyme in Escherichia coli YP_002473050.1 homology (Evalue<1e-4) to COG1782 [R] Predicted metal-dependent RNase, consists of a metallo-beta-lactamase domain and an RNA-binding KH domain YP_002473051.1 catalyzes the formation of 3-deoxy-D-arabino-hept-2-ulosonate 7 phosphate from phosphoenolpyruvate and D-erythrose 4-phosphate, phenylalanine sensitive YP_002473052.1 Condenses 4-methyl-5-(beta-hydroxyethyl)-thiazole monophosphate and 4-amino-5-hydroxymethyl pyrimidine pyrophosphate to form thiamine monophosphate YP_002473053.1 homology (Evalue<1e-4) to COG2145 [H] Hydroxyethylthiazole kinase, sugar kinase family YP_002473054.1 homology (Evalue<1e-4) to COG0351 [H] Hydroxymethylpyrimidine/phosphomethylpyrimidine kinase YP_002473055.1 homology (Evalue<1e-4) to COG0582 [L] Integrase YP_002473056.1 homology (Evalue<1e-4) to COG3378 [R] Predicted ATPase YP_002473060.1 homology (Evalue<1e-4) to COG1396 [K] Predicted transcriptional regulators YP_002473064.1 homology (Evalue<1e-4) to COG2247 [M] cell wall-binding domain YP_002473065.1 homology (Evalue<1e-4) to COG0457 [R] TPR-repeat-containing proteins YP_002473067.1 homology (Evalue<1e-4) to COG2801 [L] transposase YP_002473068.1 homology (Evalue<1e-4) to COG2801 [L] transposase YP_002473069.1 homology (Evalue<1e-4) to COG0286 [L] Type I restriction-modification system methyltransferase subunit YP_002473070.1 homology (Evalue<1e-4) to COG0732 [L] Restriction endonuclease S subunits YP_002473073.1 homology (Evalue<1e-4) to COG0582 [L] Integrase YP_002473075.1 homology (Evalue<1e-4) to COG1396 [K] Predicted transcriptional regulators YP_002473076.1 homology (Evalue<1e-4) to COG1396 [K] Predicted transcriptional regulators YP_002473077.1 homology (Evalue<1e-4) to COG3378 [R] Predicted ATPase YP_002473082.1 homology (Evalue<1e-4) to COG1196 [D] Chromosome segregation ATPases YP_002473086.1 homology (Evalue<1e-4) to COG0568 [K] DNA-directed RNA polymerase sigma subunits (sigma70/sigma32) YP_002473088.1 homology (Evalue<1e-4) to COG1278 [K] Cold shock proteins YP_002473089.1 homology (Evalue<1e-4) to COG1454 [C] Alcohol dehydrogenase IV YP_002473092.1 homology (Evalue<1e-4) to COG3547 [L] Transposase YP_002473093.1 homology (Evalue<1e-4) to COG0348 [C] Polyferredoxin YP_002473096.1 homology (Evalue<1e-4) to COG1454 [C] Alcohol dehydrogenase IV YP_002473099.1 homology (Evalue<1e-4) to COG3344 [L] Retron-type reverse transcriptase YP_002473100.1 homology (Evalue<1e-4) to COG1633 [S] Uncharacterized ACR YP_002473105.1 homology (Evalue<1e-4) to COG0110 [R] Acetyltransferases (the isoleucine patch superfamily) YP_002473106.1 homology (Evalue<1e-4) to COG0655 [R] Multimeric flavodoxin WrbA YP_002473107.1 homology (Evalue<1e-4) to COG1846 [K] Transcriptional regulators YP_002473111.1 homology (Evalue<1e-4) to COG1013 [C] Pyruvate:ferredoxin oxidoreductase and related 2-oxoacid:ferredoxin oxidoreductases, beta subunit YP_002473112.1 homology (Evalue<1e-4) to COG0674 [C] Pyruvate:ferredoxin oxidoreductase and related 2-oxoacid:ferredoxin oxidoreductases, alpha subunit YP_002473113.1 homology (Evalue<1e-4) to COG1144 [C] Pyruvate:ferredoxin oxidoreductase and related 2-oxoacid:ferredoxin oxidoreductases, delta subunit YP_002473114.1 homology (Evalue<1e-4) to COG1014 [C] Pyruvate:ferredoxin oxidoreductase and related 2-oxoacid:ferredoxin oxidoreductases, gamma subunit YP_002473115.1 homology (Evalue<1e-4) to COG1454 [C] Alcohol dehydrogenase IV YP_002473116.1 homology (Evalue<1e-4) to COG1180 [O] Pyruvate-formate lyase-activating enzyme YP_002473117.1 homology (Evalue<1e-4) to COG1882 [C] Pyruvate-formate lyase YP_002473118.1 homology (Evalue<1e-4) to COG1396 [K] Predicted transcriptional regulators YP_002473119.1 homology (Evalue<1e-4) to COG0642 [T] Signal transduction histidine kinase YP_002473120.1 homology (Evalue<1e-4) to COG0745 [TK] Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain YP_002473122.1 homology (Evalue<1e-4) to COG0840 [N] Methyl-accepting chemotaxis protein YP_002473123.1 homology (Evalue<1e-4) to COG1028 [QR] Dehydrogenases with different specificities (related to short-chain alcohol dehydrogenases) YP_002473124.1 homology (Evalue<1e-4) to COG1131 [Q] ABC-type multidrug transport system, ATPase component YP_002473125.1 homology (Evalue<1e-4) to COG1668 [C] ABC-type Na+ efflux pump, permease component YP_002473126.1 sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released; sigma 54 factor is responsible for the expression of enzymes involved in nitrogen assimilation and metabolism; the rhizobia often have 2 copies of this sigma factor; in Rhizobium etli RpoN1 shown to be involved in the assimilation of several nitrogen and carbon sources during free-living aerobic growth and RpoN2 is involved in symbiotic nitrogen fixation; in Bradyrhizobium both RpoN1 and N2 are functional in free-living and symbiotic conditions, rpoN1 gene was regulated in response to oxygen YP_002473127.1 homology (Evalue<1e-4) to COG1454 [C] Alcohol dehydrogenase IV YP_002473128.1 homology (Evalue<1e-4) to COG1012 [C] NAD-dependent aldehyde dehydrogenases YP_002473129.1 homology (Evalue<1e-4) to COG0427 [C] Acetyl-CoA hydrolase YP_002473130.1 homology (Evalue<1e-4) to COG0697 [GER] Permeases of the drug/metabolite transporter (DMT) superfamily YP_002473131.1 homology (Evalue<1e-4) to COG0427 [C] Acetyl-CoA hydrolase YP_002473132.1 homology (Evalue<1e-4) to COG0694 [O] Thioredoxin-like proteins and domains YP_002473133.1 homology (Evalue<1e-4) to COG2368 [Q] Aromatic ring hydroxylase YP_002473134.1 homology (Evalue<1e-4) to COG3829 [KT] Transcriptional regulator containing PAS, AAA-type ATPase, and DNA-binding domains YP_002473135.1 homology (Evalue<1e-4) to COG2030 [I] Predicted acyl dehydratase YP_002473138.1 homology (Evalue<1e-4) to COG0318 [IQ] Acyl-CoA synthetases (AMP-forming)/AMP-acid ligases II YP_002473140.1 homology (Evalue<1e-4) to COG0662 [G] Mannose-6-phosphate isomerase YP_002473142.1 homology (Evalue<1e-4) to COG3402 [S] Uncharacterized ACR YP_002473143.1 homology (Evalue<1e-4) to COG3428 [S] Predicted membrane protein YP_002473149.1 homology (Evalue<1e-4) to COG1309 [K] Transcriptional regulator YP_002473150.1 homology (Evalue<1e-4) to COG0477 [GEPR] Permeases of the major facilitator superfamily YP_002473151.1 homology (Evalue<1e-4) to COG0577 [R] ABC-type transport systems, involved in lipoprotein release, permease components YP_002473152.1 homology (Evalue<1e-4) to COG1136 [R] ABC-type transport systems, involved in lipoprotein release, ATPase components YP_002473153.1 homology (Evalue<1e-4) to COG0642 [T] Signal transduction histidine kinase YP_002473154.1 homology (Evalue<1e-4) to COG0745 [TK] Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain YP_002473155.1 homology (Evalue<1e-4) to COG0642 [T] Signal transduction histidine kinase YP_002473156.1 homology (Evalue<1e-4) to COG0745 [TK] Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain YP_002473157.1 homology (Evalue<1e-4) to COG1131 [Q] ABC-type multidrug transport system, ATPase component YP_002473158.1 homology (Evalue<1e-4) to COG1277 [R] ABC-type transport system involved in multi-copper enzyme maturation, permease component YP_002473160.1 converts 2-oxoglutarate to glutamate; in Escherichia coli this enzyme plays a role in glutamate synthesis when the cell is under energy restriction; uses NADPH; forms a homohexamer YP_002473161.1 homology (Evalue<1e-4) to COG0803 [P] ABC-type Mn/Zn transport system, periplasmic Mn/Zn-binding (lipo)protein (surface adhesin A) YP_002473163.1 homology (Evalue<1e-4) to COG0840 [N] Methyl-accepting chemotaxis protein YP_002473164.1 homology (Evalue<1e-4) to COG1126 [E] ABC-type polar amino acid transport system, ATPase component YP_002473165.1 homology (Evalue<1e-4) to COG1940 [K] Transcriptional regulators YP_002473166.1 homology (Evalue<1e-4) to COG0715 [P] ABC-type nitrate/sulfonate/taurine/bicarbonate transport systems, periplasmic components YP_002473167.1 homology (Evalue<1e-4) to COG0600 [P] ABC-type nitrate/sulfonate/taurine/bicarbonate transport systems, permease components YP_002473168.1 homology (Evalue<1e-4) to COG1116 [P] ABC-type nitrate/sulfonate/taurine/bicarbonate transport systems, ATPase components YP_002473169.1 homology (Evalue<1e-4) to COG1053 [C] Succinate dehydrogenase/fumarate reductase, flavoprotein subunits YP_002473170.1 homology (Evalue<1e-4) to COG1146 [C] Ferredoxin 3 YP_002473172.1 catalyzes the formation of L-tryptophan from indole and L-serine YP_002473174.1 homology (Evalue<1e-4) to COG0568 [K] DNA-directed RNA polymerase sigma subunits (sigma70/sigma32) YP_002473182.1 homology (Evalue<1e-4) to COG1538 [MN] Outer membrane protein YP_002473183.1 homology (Evalue<1e-4) to COG2247 [M] cell wall-binding domain YP_002473184.1 homology (Evalue<1e-4) to COG2247 [M] cell wall-binding domain YP_002473185.1 homology (Evalue<1e-4) to COG0535 [R] Predicted Fe-S oxidoreductases YP_002473186.1 functions with NifN to assemble FeMo cofactor; functions in assembly of nitrogenase MoFe YP_002473187.1 homology (Evalue<1e-4) to COG2710 [C] Nitrogenase molybdenum-iron protein, alpha and beta chains YP_002473188.1 homology (Evalue<1e-4) to COG2710 [C] Nitrogenase molybdenum-iron protein, alpha and beta chains YP_002473189.1 homology (Evalue<1e-4) to COG0347 [E] Nitrogen regulatory protein PII YP_002473190.1 homology (Evalue<1e-4) to COG0347 [E] Nitrogen regulatory protein PII YP_002473191.1 homology (Evalue<1e-4) to COG1348 [P] Nitrogenase subunit NifH (ATPase) YP_002473192.1 homology (Evalue<1e-4) to COG1910 [P] Periplasmic molybdate-binding protein (domain) YP_002473194.1 homology (Evalue<1e-4) to COG3585 [H] Molybdopterin-binding protein YP_002473195.1 homology (Evalue<1e-4) to COG1118 [P] ABC-type sulfate/molybdate transport systems, ATPase component YP_002473196.1 homology (Evalue<1e-4) to COG0555 [P] ABC-type sulfate/molybdate transport systems, permease components YP_002473197.1 homology (Evalue<1e-4) to COG0725 [P] ABC-type molybdate transport system, periplasmic component YP_002473199.1 homology (Evalue<1e-4) to COG0840 [N] Methyl-accepting chemotaxis protein YP_002473201.1 homology (Evalue<1e-4) to COG0675 [L] Predicted transposases YP_002473204.1 homology (Evalue<1e-4) to COG1196 [D] Chromosome segregation ATPases YP_002473205.1 homology (Evalue<1e-4) to COG0582 [L] Integrase YP_002473207.1 homology (Evalue<1e-4) to COG2931 [Q] RTX toxins and related Ca2+-binding proteins YP_002473210.1 homology (Evalue<1e-4) to COG2931 [Q] RTX toxins and related Ca2+-binding proteins YP_002473212.1 homology (Evalue<1e-4) to COG2247 [M] cell wall-binding domain YP_002473213.1 homology (Evalue<1e-4) to COG2247 [M] cell wall-binding domain YP_002473214.1 homology (Evalue<1e-4) to COG3773 [M] Cell wall hydrolyses involved in spore germination YP_002473216.1 homology (Evalue<1e-4) to COG0037 [D] Predicted ATPase of the PP-loop superfamily implicated in cell cycle control YP_002473217.1 homology (Evalue<1e-4) to COG0642 [T] Signal transduction histidine kinase YP_002473222.1 homology (Evalue<1e-4) to COG0642 [T] Signal transduction histidine kinase YP_002473223.1 homology (Evalue<1e-4) to COG0840 [N] Methyl-accepting chemotaxis protein YP_002473224.1 homology (Evalue<1e-4) to COG0160 [E] PLP-dependent aminotransferases YP_002473225.1 homology (Evalue<1e-4) to COG2508 [TQ] Regulator of polyketide synthase expression YP_002473228.1 homology (Evalue<1e-4) to COG1272 [R] Predicted membrane proteins, hemolysin III homologs YP_002473230.1 homology (Evalue<1e-4) to COG0697 [GER] Permeases of the drug/metabolite transporter (DMT) superfamily YP_002473231.1 catalyzes a two-step reaction, first charging an aspartate molecule by linking its carboxyl group to the alpha-phosphate of ATP, followed by transfer of the aminoacyl-adenylate to its tRNA; contains discriminating and non-discriminating subtypes YP_002473232.1 catalyzes a two-step reaction, first charging a histidine molecule by linking its carboxyl group to the alpha-phosphate of ATP, followed by transfer of the aminoacyl-adenylate to its tRNA; class II aminoacyl-tRNA synthetase; forms homodimers; some organisms have a paralogous gene, hisZ, that is similar to hisS and produces a protein that performs the first step in histidine biosynthesis along with HisG YP_002473233.1 catalyzes the oxygen-independent formation of protoporphyrinogen-IX from coproporphyrinogen-III YP_002473234.1 homology (Evalue<1e-4) to COG0491 [R] Zn-dependent hydrolases, including glyoxylases YP_002473235.1 hydrolyzes D-tyrosyl-tRNA(Tyr) into D-tyrosine and free tRNA(Tyr); possible defense mechanism against a harmful effect of D-tyrosine YP_002473236.1 homology (Evalue<1e-4) to COG0317 [TK] Guanosine polyphosphate pyrophosphohydrolases/synthetases YP_002473237.1 catalyzes a salvage reaction resulting in the formation of AMP which is metabolically less costly than a de novo synthesis YP_002473238.1 homology (Evalue<1e-4) to COG0675 [L] Predicted transposases YP_002473239.1 homology (Evalue<1e-4) to COG0608 [L] Single-stranded DNA-specific exonuclease YP_002473240.1 forms a complex with SecD and YajC; SecDFyajC stimulates the proton motive force-driven protein translocation; seems to modulate the cycling of SecA by stabilizing its membrane-inserted state and appears to be required for the release of mature proteins from the extracytoplasmic side of the membrane; in some organisms, such as Bacillus subtilis, SecD is fused to SecF YP_002473241.1 part of the preprotein secretory system; when complexed with proteins SecF and YajC, SecDFyajC stimulates the proton motive force-driven protein translocation, and appears to be required for the release of mature proteins from the extracytoplasmic side of the membrane YP_002473242.1 homology (Evalue<1e-4) to COG0535 [R] Predicted Fe-S oxidoreductases YP_002473244.1 homology (Evalue<1e-4) to COG1862 [N] Preprotein translocase subunit YajC YP_002473245.1 Exchanges the guanine residue with 7-aminomethyl-7-deazaguanine in tRNAs with GU(N) anticodons (tRNA-Asp, -Asn, -His and -Tyr) YP_002473246.1 Synthesizes oQ from preQ1 in a single S-adenosylmethionine-requiring step YP_002473247.1 promotes strand exchange during homologous recombination; RuvAB complex promotes branch migration; RuvABC complex scans the DNA during branch migration and resolves Holliday junctions at consensus sequences; forms hexameric rings around opposite DNA arms; requires ATP for branch migration and orientation of RuvAB complex determines direction of migration YP_002473248.1 plays an essential role in ATP-dependent branch migration of the Holliday junction YP_002473250.1 homology (Evalue<1e-4) to COG2333 [R] Predicted hydrolases of metallo-beta-lactamase fold YP_002473251.1 homology (Evalue<1e-4) to COG0217 [S] Uncharacterized ACR YP_002473252.1 homology (Evalue<1e-4) to COG1739 [S] Uncharacterized ACR YP_002473253.1 homology (Evalue<1e-4) to COG1167 [KE] Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain (MocR family) and their eukaryotic orthologs YP_002473255.1 homology (Evalue<1e-4) to COG2262 [R] GTPases YP_002473256.1 homology (Evalue<1e-4) to COG0744 [M] Membrane carboxypeptidase (penicillin-binding protein) YP_002473257.1 sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released; this sigma factor is responsible for the expression of sporulation specific genes and is expressed in the prespore at the onset of sporulation. Interaction with spoIIAB inhibits sigma F activity throughout the cell before the formation of the asymmetric septum; after septation the interaction is confined to the mother cell, and sigma F activity is released in the prespore. YP_002473258.1 binds to sigma F preventing its association with RNA polymerase during sporulation YP_002473259.1 homology (Evalue<1e-4) to COG1366 [T] Anti-anti-sigma regulatory factor (antagonist of anti-sigma factor) YP_002473260.1 catalyzes the formation of spermidine from putrescine and S-adenosylmethioninamine YP_002473261.1 homology (Evalue<1e-4) to COG1002 [L] Type II restriction enzyme, methylase subunits YP_002473262.1 homology (Evalue<1e-4) to COG0726 [G] Predicted xylanase/chitin deacetylase YP_002473263.1 homology (Evalue<1e-4) to COG1922 [M] Teichoic acid biosynthesis proteins YP_002473264.1 homology (Evalue<1e-4) to COG2148 [M] Sugar transferases involved in lipopolysaccharide synthesis YP_002473265.1 homology (Evalue<1e-4) to COG3274 [S] Uncharacterized BCR YP_002473266.1 homology (Evalue<1e-4) to COG0728 [R] Uncharacterized membrane protein, virulence factor YP_002473267.1 homology (Evalue<1e-4) to COG0438 [M] Predicted glycosyltransferases YP_002473268.1 homology (Evalue<1e-4) to COG3307 [M] Lipid A core - O-antigen ligase and related enzymes YP_002473269.1 homology (Evalue<1e-4) to COG0381 [M] UDP-N-acetylglucosamine 2-epimerase YP_002473270.1 homology (Evalue<1e-4) to COG0110 [R] Acetyltransferases (the isoleucine patch superfamily) YP_002473271.1 homology (Evalue<1e-4) to COG0673 [R] Predicted dehydrogenases and related proteins YP_002473272.1 homology (Evalue<1e-4) to COG0677 [M] UDP-N-acetyl-D-mannosaminuronate dehydrogenase YP_002473273.1 homology (Evalue<1e-4) to COG2182 [G] Maltose-binding periplasmic proteins/domains YP_002473274.1 homology (Evalue<1e-4) to COG0728 [R] Uncharacterized membrane protein, virulence factor YP_002473275.1 homology (Evalue<1e-4) to COG3594 [G] Fucose 4-O-acetylase and related acetyltransferases YP_002473277.1 homology (Evalue<1e-4) to COG0463 [M] Glycosyltransferases involved in cell wall biogenesis YP_002473278.1 homology (Evalue<1e-4) to COG0438 [M] Predicted glycosyltransferases YP_002473279.1 homology (Evalue<1e-4) to COG0438 [M] Predicted glycosyltransferases YP_002473280.1 homology (Evalue<1e-4) to COG1086 [MG] Predicted nucleoside-diphosphate sugar epimerases YP_002473281.1 homology (Evalue<1e-4) to COG1210 [M] UDP-glucose pyrophosphorylase YP_002473282.1 homology (Evalue<1e-4) to COG0457 [R] TPR-repeat-containing proteins YP_002473283.1 homology (Evalue<1e-4) to COG1109 [G] Phosphomannomutase YP_002473284.1 homology (Evalue<1e-4) to COG1982 [E] Arginine/lysine/ornithine decarboxylases YP_002473285.1 homology (Evalue<1e-4) to COG1683 [S] Uncharacterized ACR YP_002473286.1 MutS2; MutS-II; involved in blocking homologous and homeologous recombination; has ATPase activity stimulated by recombination intermediates; inhibits DNA strand exchange YP_002473287.1 homology (Evalue<1e-4) to COG0826 [O] Collagenase and related proteases YP_002473290.1 homology (Evalue<1e-4) to COG1196 [D] Chromosome segregation ATPases YP_002473293.1 homology (Evalue<1e-4) to COG3027 [S] Uncharacterized BCR YP_002473294.1 catalyzes a two-step reaction, first charging a phenylalanine molecule by linking its carboxyl group to the alpha-phosphate of ATP, followed by transfer of the aminoacyl-adenylate to its tRNA; forms a tetramer of alpha(2)beta(2); binds two magnesium ions per tetramer; type 2 subfamily YP_002473295.1 catalyzes a two-step reaction, first charging a phenylalanine molecule by linking its carboxyl group to the alpha-phosphate of ATP, followed by transfer of the aminoacyl-adenylate to its tRNA; forms a heterotetramer of alpha(2)beta(2); binds two magnesium ions per tetramer; type 1 subfamily YP_002473296.1 homology (Evalue<1e-4) to COG0566 [J] rRNA methylases YP_002473297.1 binds directly to 23S ribosomal RNA prior to in vitro assembly of the 50S ribosomal subunit YP_002473298.1 homology (Evalue<1e-4) to COG0291 [J] Ribosomal protein L35 YP_002473299.1 catalyzes a two-step reaction, first charging a threonine molecule by linking its carboxyl group to the alpha-phosphate of ATP, followed by transfer of the aminoacyl-adenylate to its tRNA; catalyzes the formation of threonyl-tRNA(Thr) from threonine and tRNA(Thr) YP_002473301.1 homology (Evalue<1e-4) to COG0642 [T] Signal transduction histidine kinase YP_002473302.1 homology (Evalue<1e-4) to COG0436 [E] PLP-dependent aminotransferases YP_002473303.1 catalyzes the reduction of 2,3-dihydrodipicolinate to 2,3,4,5-tetrahydrodipicolinate in lysine and diaminopimelate biosynthesis YP_002473304.1 catalyzes the formation of dihydrodipicolinate from L-aspartate 4-semialdehyde and pyruvate in lysine and diaminopimelate biosynthesis YP_002473305.1 homology (Evalue<1e-4) to COG0136 [E] Aspartate-semialdehyde dehydrogenase YP_002473307.1 homology (Evalue<1e-4) to COG0500 [QR] SAM-dependent methyltransferases YP_002473308.1 becomes active under oxidative stress; four conserved cysteines bind a zinc atom when they are in the reduced state and the enzyme is inactive; oxidative stress results in oxidized cysteines, release of zinc, and binding of Hsp33 to aggregation-prone proteins; forms dimers and higher order oligomers YP_002473309.1 homology (Evalue<1e-4) to COG2171 [E] Tetrahydrodipicolinate N-succinyltransferase YP_002473310.1 binds to single stranded DNA and may facilitate the binding and interaction of other proteins to DNA YP_002473312.1 homology (Evalue<1e-4) to COG0726 [G] Predicted xylanase/chitin deacetylase YP_002473314.1 homology (Evalue<1e-4) to COG3391 [S] Uncharacterized ACR YP_002473316.1 homology (Evalue<1e-4) to COG0285 [H] Folylpolyglutamate synthase YP_002473317.1 valine--tRNA ligase; ValRS; converts valine ATP and tRNA(Val) to AMP PPi and valyl-tRNA(Val); class-I aminoacyl-tRNA synthetase type 1 subfamily; has a posttransfer editing process to hydrolyze mischarged Thr-tRNA(Val) which is done by the editing domain YP_002473318.1 homology (Evalue<1e-4) to COG0715 [P] ABC-type nitrate/sulfonate/taurine/bicarbonate transport systems, periplasmic components YP_002473319.1 homology (Evalue<1e-4) to COG1396 [K] Predicted transcriptional regulators YP_002473326.1 homology (Evalue<1e-4) to COG1961 [L] Site-specific recombinases, DNA invertase Pin homologs YP_002473328.1 homology (Evalue<1e-4) to COG3378 [R] Predicted ATPase YP_002473329.1 homology (Evalue<1e-4) to COG1396 [K] Predicted transcriptional regulators YP_002473330.1 homology (Evalue<1e-4) to COG2189 [L] Adenine specific DNA methylase Mod YP_002473331.1 homology (Evalue<1e-4) to COG3587 [L] Restriction endonuclease YP_002473332.1 homology (Evalue<1e-4) to COG3593 [L] Predicted ATP-dependent endonuclease of the OLD family YP_002473334.1 homology (Evalue<1e-4) to COG3757 [M] Lyzozyme M1 (1,4-beta-N-acetylmuramidase) YP_002473337.1 homology (Evalue<1e-4) to COG2931 [Q] RTX toxins and related Ca2+-binding proteins YP_002473340.1 homology (Evalue<1e-4) to COG3299 [S] Uncharacterized homolog of phage Mu protein gp47 YP_002473344.1 homology (Evalue<1e-4) to COG1652 [S] Uncharacterized protein containing LysM domain YP_002473346.1 homology (Evalue<1e-4) to COG0840 [N] Methyl-accepting chemotaxis protein YP_002473364.1 homology (Evalue<1e-4) to COG1783 [R] Phage terminase large subunit YP_002473365.1 homology (Evalue<1e-4) to COG3728 [L] Phage terminase, small subunit YP_002473367.1 homology (Evalue<1e-4) to COG1598 [S] Uncharacterized ACR YP_002473373.1 homology (Evalue<1e-4) to COG0270 [L] Site-specific DNA methylase YP_002473375.1 homology (Evalue<1e-4) to COG0338 [L] Site-specific DNA methylase YP_002473376.1 homology (Evalue<1e-4) to COG0305 [L] Replicative DNA helicase YP_002473386.1 homology (Evalue<1e-4) to COG1476 [K] Predicted transcriptional regulators YP_002473387.1 homology (Evalue<1e-4) to COG1396 [K] Predicted transcriptional regulators YP_002473389.1 homology (Evalue<1e-4) to COG1476 [K] Predicted transcriptional regulators YP_002473390.1 homology (Evalue<1e-4) to COG1396 [K] Predicted transcriptional regulators YP_002473391.1 homology (Evalue<1e-4) to COG3290 [T] Signal transduction histidine kinase regulating citrate/malate metabolism YP_002473393.1 homology (Evalue<1e-4) to COG1961 [L] Site-specific recombinases, DNA invertase Pin homologs YP_002473394.1 homology (Evalue<1e-4) to COG0426 [C] Uncharacterized flavoproteins YP_002473395.1 homology (Evalue<1e-4) to COG0491 [R] Zn-dependent hydrolases, including glyoxylases YP_002473396.1 homology (Evalue<1e-4) to COG1924 [I] Activator of 2-hydroxyglutaryl-CoA dehydratase (HSP70-class ATPase domain) YP_002473397.1 homology (Evalue<1e-4) to COG1116 [P] ABC-type nitrate/sulfonate/taurine/bicarbonate transport systems, ATPase components YP_002473398.1 homology (Evalue<1e-4) to COG0600 [P] ABC-type nitrate/sulfonate/taurine/bicarbonate transport systems, permease components YP_002473399.1 homology (Evalue<1e-4) to COG0457 [R] TPR-repeat-containing proteins YP_002473400.1 homology (Evalue<1e-4) to COG1305 [E] Transglutaminase-like enzymes, cysteine proteases YP_002473401.1 homology (Evalue<1e-4) to COG3547 [L] Transposase YP_002473402.1 binds RecA and inhibits RecA-mediated DNA strand exchange and ATP hydrolysis and coprotease activities YP_002473403.1 homology (Evalue<1e-4) to COG0612 [R] Predicted Zn-dependent peptidases YP_002473404.1 homology (Evalue<1e-4) to COG0513 [LKJ ] Superfamily II DNA and RNA helicases YP_002473405.1 homology (Evalue<1e-4) to COG1543 [S] Uncharacterized ACR YP_002473407.1 homology (Evalue<1e-4) to COG2606 [S] Uncharacterized ACR YP_002473408.1 homology (Evalue<1e-4) to COG0782 [K] Transcription elongation factor YP_002473409.1 homology (Evalue<1e-4) to COG0020 [I] Undecaprenyl pyrophosphate synthase YP_002473410.1 homology (Evalue<1e-4) to COG0674 [C] Pyruvate:ferredoxin oxidoreductase and related 2-oxoacid:ferredoxin oxidoreductases, alpha subunit YP_002473411.1 homology (Evalue<1e-4) to COG0053 [P] Predicted Co/Zn/Cd cation transporters YP_002473413.1 homology (Evalue<1e-4) to COG1477 [H] Membrane-associated lipoprotein involved in thiamine biosynthesis YP_002473414.1 catalyzes the formation of adenosylcobalamin from Ado-cobinamide-GDP and alpha-ribazole YP_002473415.1 homology (Evalue<1e-4) to COG0735 [P] Fe2+/Zn2+ uptake regulation proteins YP_002473416.1 homology (Evalue<1e-4) to COG1653 [G] Sugar-binding periplasmic proteins/domains YP_002473418.1 homology (Evalue<1e-4) to COG2378 [K] Predicted transcriptional regulator YP_002473420.1 homology (Evalue<1e-4) to COG1266 [R] Predicted metal-dependent membrane protease YP_002473421.1 binds guanine nucleotides; in Escherichia coli depletion results in defective cell division and filamentation; in Bacillus subtilis this gene is essential YP_002473422.1 homology (Evalue<1e-4) to COG0466 [O] ATP-dependent Lon protease, bacterial type YP_002473423.1 binds and unfolds substrates as part of the ClpXP protease YP_002473424.1 hydrolyzes proteins to small peptides; with the ATPase subunits ClpA or ClpX, ClpP degrades specific substrates YP_002473425.1 Tig; RopA; peptidyl-prolyl cis/trans isomerase; promotes folding of newly synthesized proteins; binds ribosomal 50S subunit; forms a homodimer YP_002473426.1 homology (Evalue<1e-4) to COG1082 [G] Sugar phosphate isomerases/epimerases YP_002473428.1 involved in fifth step of pyrimidine biosynthesis; converts orotidine 5'-phosphate and diphosphate to orotate and 5-phospho-alpha-D-ribose 1-diphosphate YP_002473429.1 homology (Evalue<1e-4) to COG0167 [F] Dihydroorotate dehydrogenase YP_002473430.1 responsible for channeling the electrons from the oxidation of dihydroorotate from the FMN redox center in the pyrD subunit to the ultimate electron acceptor NAD(+) YP_002473431.1 type 2 subfamily; involved in last step of pyrimidine biosynthesis; converts orotidine 5'-phosphate to UMP and carbon dioxide; OMP decarboxylase; OMPDCase; OMPdecase YP_002473432.1 homology (Evalue<1e-4) to COG0044 [F] Dihydroorotase and related cyclic amidohydrolases YP_002473433.1 involved in the allosteric regulation of aspartate carbamoyltransferase YP_002473434.1 catalyzes the transfer of the carbamoyl moiety from carbamoyl phosphate to L- aspartate in pyrimidine biosynthesis YP_002473435.1 homology (Evalue<1e-4) to COG1321 [K] Mn-dependent transcriptional regulator YP_002473436.1 homology (Evalue<1e-4) to COG1210 [M] UDP-glucose pyrophosphorylase YP_002473439.1 homology (Evalue<1e-4) to COG0655 [R] Multimeric flavodoxin WrbA YP_002473441.1 homology (Evalue<1e-4) to COG3290 [T] Signal transduction histidine kinase regulating citrate/malate metabolism YP_002473443.1 homology (Evalue<1e-4) to COG0347 [E] Nitrogen regulatory protein PII YP_002473444.1 homology (Evalue<1e-4) to COG0004 [P] Ammonia permeases YP_002473445.1 homology (Evalue<1e-4) to COG0531 [E] Amino acid transporters YP_002473446.1 homology (Evalue<1e-4) to COG0583 [K] Transcriptional regulator YP_002473447.1 binds to ssrA RNA (tmRNA) and is required for its successful binding to ribosomes; also appears to function in the trans-translation step by promoting accommodation of tmRNA into the ribosomal A site; SmpB protects the tmRNA from RNase R degradation in Caulobacter crescentus; both the tmRNA and SmpB are regulated in cell cycle-dependent manner; functions in release of stalled ribosomes from damaged mRNAs and targeting proteins for degradation YP_002473448.1 homology (Evalue<1e-4) to COG0557 [K] Exoribonucleases YP_002473449.1 homology (Evalue<1e-4) to COG1314 [N] Preprotein translocase subunit YP_002473450.1 enolase; catalyzes the formation of phosphoenolpyruvate from 2-phospho-D-glycerate in glycolysis YP_002473451.1 catalyzes the interconversion of 2-phosphoglycerate and 3-phosphoglycerate YP_002473452.1 Reversibly isomerizes the ketone sugar dihydroxyacetone phosphate to the aldehyde sugar glyceraldehyde-3-phosphate YP_002473453.1 Converts 3-phospho-D-glycerate to 3-phospho-D-glyceroyl phosphate during the glycolysis pathway YP_002473454.1 homology (Evalue<1e-4) to COG0057 [G] Glyceraldehyde-3-phosphate dehydrogenase/erythrose-4-phosphate dehydrogenase YP_002473455.1 homology (Evalue<1e-4) to COG1307 [S] Uncharacterized BCR YP_002473456.1 homology (Evalue<1e-4) to COG0219 [J] Predicted rRNA methylase (SpoU class) YP_002473457.1 homology (Evalue<1e-4) to COG1533 [L] DNA repair photolyase YP_002473458.1 homology (Evalue<1e-4) to COG0860 [M] N-acetylmuramoyl-L-alanine amidase YP_002473461.1 homology (Evalue<1e-4) to COG0697 [GER] Permeases of the drug/metabolite transporter (DMT) superfamily YP_002473463.1 homology (Evalue<1e-4) to COG0577 [R] ABC-type transport systems, involved in lipoprotein release, permease components YP_002473464.1 homology (Evalue<1e-4) to COG1136 [R] ABC-type transport systems, involved in lipoprotein release, ATPase components YP_002473465.1 homology (Evalue<1e-4) to COG0642 [T] Signal transduction histidine kinase YP_002473466.1 homology (Evalue<1e-4) to COG0745 [TK] Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain YP_002473467.1 homology (Evalue<1e-4) to COG3547 [L] Transposase YP_002473469.1 homology (Evalue<1e-4) to COG3655 [K] Predicted transcriptional regulator YP_002473471.1 homology (Evalue<1e-4) to COG3326 [S] Predicted membrane protein YP_002473472.1 homology (Evalue<1e-4) to COG1846 [K] Transcriptional regulators YP_002473473.1 homology (Evalue<1e-4) to COG0477 [GEPR] Permeases of the major facilitator superfamily YP_002473474.1 homology (Evalue<1e-4) to COG0671 [I] Membrane-associated phospholipid phosphatase YP_002473475.1 homology (Evalue<1e-4) to COG0531 [E] Amino acid transporters YP_002473476.1 homology (Evalue<1e-4) to COG2801 [L] transposase YP_002473477.1 homology (Evalue<1e-4) to COG1196 [D] Chromosome segregation ATPases YP_002473478.1 homology (Evalue<1e-4) to COG2720 [S] Uncharacterized BCR, vancomycin resistance protein YP_002473479.1 homology (Evalue<1e-4) to COG1058 [R] Predicted nucleotide-utilizing enzyme related to molybdopterin-biosynthesis enzyme MoeA YP_002473480.1 homology (Evalue<1e-4) to COG0177 [L] Predicted EndoIII-related endonuclease YP_002473481.1 homology (Evalue<1e-4) to COG0204 [I] 1-acyl-sn-glycerol-3-phosphate acyltransferase YP_002473482.1 homology (Evalue<1e-4) to COG1045 [E] Serine acetyltransferase YP_002473483.1 homology (Evalue<1e-4) to COG0031 [E] Cysteine synthase YP_002473484.1 homology (Evalue<1e-4) to COG1295 [R] Predicted multitransmembrane protein YP_002473488.1 homology (Evalue<1e-4) to COG1592 [C] Rubrerythrin YP_002473489.1 homology (Evalue<1e-4) to COG1482 [G] Phosphomannose isomerase YP_002473492.1 homology (Evalue<1e-4) to COG2364 [R] Uncharacterized membrane protein YP_002473493.1 homology (Evalue<1e-4) to COG2119 [S] Predicted membrane protein YP_002473494.1 homology (Evalue<1e-4) to COG0697 [GER] Permeases of the drug/metabolite transporter (DMT) superfamily YP_002473495.1 homology (Evalue<1e-4) to COG1454 [C] Alcohol dehydrogenase IV YP_002473496.1 homology (Evalue<1e-4) to COG1122 [P] ABC-type cobalt transport system, ATPase component YP_002473497.1 homology (Evalue<1e-4) to COG0619 [P] ABC-type cobalt transport system, permease component CbiQ and related transporters YP_002473498.1 periplasmic cobalt binding component of the cobalt transport system YP_002473499.1 catalyzes the ATP-dependent transport of cobalt YP_002473500.1 homology (Evalue<1e-4) to COG3434 [T] Predicted signal transduction protein containing EAL and modified HD-GYP domains YP_002473501.1 homology (Evalue<1e-4) to COG0840 [N] Methyl-accepting chemotaxis protein YP_002473502.1 homology (Evalue<1e-4) to COG0605 [P] Superoxide dismutase YP_002473504.1 homology (Evalue<1e-4) to COG0735 [P] Fe2+/Zn2+ uptake regulation proteins YP_002473505.1 homology (Evalue<1e-4) to COG0840 [N] Methyl-accepting chemotaxis protein YP_002473506.1 homology (Evalue<1e-4) to COG1454 [C] Alcohol dehydrogenase IV YP_002473507.1 homology (Evalue<1e-4) to COG1902 [C] NADH:flavin oxidoreductases, Old Yellow Enzyme family YP_002473508.1 homology (Evalue<1e-4) to COG3284 [Q] Transcriptional activator of acetoin/glycerol metabolism YP_002473509.1 homology (Evalue<1e-4) to COG0389 [L] Nucleotidyltransferase/DNA polymerase involved in DNA repair YP_002473510.1 homology (Evalue<1e-4) to COG0840 [N] Methyl-accepting chemotaxis protein YP_002473511.1 homology (Evalue<1e-4) to COG0655 [R] Multimeric flavodoxin WrbA YP_002473512.1 homology (Evalue<1e-4) to COG2801 [L] transposase YP_002473517.1 homology (Evalue<1e-4) to COG0622 [R] Predicted phosphoesterase YP_002473518.1 HAM1-like protein; Rec-dependent growth; RgdB; yggV; it is suspected that this protein functions to remove misincorporated bases such as xanthine or hypoxanthine YP_002473519.1 RNase PH; tRNA nucleotidyltransferase; forms hexamers in Bacillus subtilis; phosphoroltic 3'-5' exoribonuclease; involved in maturation of tRNA precursors and removes terminal nucleotides near CCA acceptor arms of mature tRNAs YP_002473520.1 homology (Evalue<1e-4) to COG0309 [O] Hydrogenase maturation factor YP_002473522.1 homology (Evalue<1e-4) to COG0747 [EP] ABC-type dipeptide/oligopeptide/nickel transport systems, periplasmic components YP_002473524.1 allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp-tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases; reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA YP_002473525.1 allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp-tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases; reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA YP_002473526.1 allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp-tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases; reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA; some Mycoplasma proteins contain an N-terminal fusion to an unknown domain YP_002473528.1 homology (Evalue<1e-4) to COG1752 [R] Predicted esterase of the alpha-beta hydrolase superfamily YP_002473529.1 homology (Evalue<1e-4) to COG0535 [R] Predicted Fe-S oxidoreductases YP_002473530.1 homology (Evalue<1e-4) to COG0706 [N] Preprotein translocase subunit YidC YP_002473531.1 homology (Evalue<1e-4) to COG1418 [R] Predicted HD superfamily hydrolase YP_002473533.1 homology (Evalue<1e-4) to COG0661 [R] Predicted unusual protein kinase YP_002473535.1 homology (Evalue<1e-4) to COG1309 [K] Transcriptional regulator YP_002473536.1 homology (Evalue<1e-4) to COG0272 [L] NAD-dependent DNA ligase (contains BRCT domain type II) YP_002473537.1 homology (Evalue<1e-4) to COG0210 [L] Superfamily I DNA and RNA helicases YP_002473539.1 homology (Evalue<1e-4) to COG1187 [J] 16S rRNA uridine-516 pseudouridylate synthase and related pseudouridylate synthases YP_002473540.1 homology (Evalue<1e-4) to COG0741 [M] Soluble lytic murein transglycosylase and related regulatory proteins (some contain LysM/invasin domains) YP_002473542.1 homology (Evalue<1e-4) to COG1523 [G] Pullulanase and related glycosidases YP_002473543.1 homology (Evalue<1e-4) to COG1671 [S] Uncharacterized BCR YP_002473544.1 homology (Evalue<1e-4) to COG0166 [G] Glucose-6-phosphate isomerase YP_002473546.1 homology (Evalue<1e-4) to COG0448 [G] ADP-glucose pyrophosphorylase YP_002473547.1 catalyzes the formation of ADP-glucose and diphosphate from ATP and alpha-D-glucose 1-phosphate YP_002473548.1 homology (Evalue<1e-4) to COG0366 [G] Glycosidases YP_002473549.1 homology (Evalue<1e-4) to COG0058 [G] Glucan phosphorylase YP_002473550.1 catalyzes the formation of alpha-1,4-glucan chains from ADP-glucose YP_002473551.1 homology (Evalue<1e-4) to COG0296 [G] 1,4-alpha-glucan branching enzyme YP_002473552.1 homology (Evalue<1e-4) to COG0706 [N] Preprotein translocase subunit YidC YP_002473553.1 homology (Evalue<1e-4) to COG3682 [K] Predicted transcriptional regulator YP_002473555.1 homology (Evalue<1e-4) to COG0534 [Q] Na+-driven multidrug efflux pump YP_002473556.1 homology (Evalue<1e-4) to COG1846 [K] Transcriptional regulators YP_002473560.1 homology (Evalue<1e-4) to COG0477 [GEPR] Permeases of the major facilitator superfamily YP_002473561.1 homology (Evalue<1e-4) to COG1309 [K] Transcriptional regulator YP_002473562.1 homology (Evalue<1e-4) to COG0845 [Q] Membrane-fusion protein YP_002473563.1 homology (Evalue<1e-4) to COG1131 [Q] ABC-type multidrug transport system, ATPase component YP_002473564.1 homology (Evalue<1e-4) to COG0842 [R] ABC-type multidrug transport system, permease component YP_002473565.1 homology (Evalue<1e-4) to COG0332 [I] 3-oxoacyl-acyl-carrier-protein synthase III YP_002473567.1 homology (Evalue<1e-4) to COG0277 [C] FAD/FMN-containing dehydrogenases YP_002473568.1 homology (Evalue<1e-4) to COG2025 [C] Electron transfer flavoprotein alpha-subunit YP_002473569.1 homology (Evalue<1e-4) to COG2086 [C] Electron transfer flavoprotein beta-subunit YP_002473570.1 homology (Evalue<1e-4) to COG1253 [N] Hemolysins and related proteins containing CBS domains YP_002473571.1 homology (Evalue<1e-4) to COG1277 [R] ABC-type transport system involved in multi-copper enzyme maturation, permease component YP_002473572.1 homology (Evalue<1e-4) to COG1131 [Q] ABC-type multidrug transport system, ATPase component YP_002473573.1 homology (Evalue<1e-4) to COG0745 [TK] Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain YP_002473574.1 homology (Evalue<1e-4) to COG0664 [T] cAMP-binding domains - Catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases YP_002473577.1 homology (Evalue<1e-4) to COG1113 [E] Gamma-aminobutyrate permease and related permeases YP_002473578.1 catalyzes the formation of tyrosyl-tRNA(Tyr) from tyrosine and tRNA(Tyr) YP_002473579.1 homology (Evalue<1e-4) to COG0730 [R] Predicted permeases YP_002473583.1 homology (Evalue<1e-4) to COG1961 [L] Site-specific recombinases, DNA invertase Pin homologs YP_002473584.1 homology (Evalue<1e-4) to COG0842 [R] ABC-type multidrug transport system, permease component YP_002473585.1 homology (Evalue<1e-4) to COG1131 [Q] ABC-type multidrug transport system, ATPase component YP_002473589.1 homology (Evalue<1e-4) to COG1695 [K] Predicted transcriptional regulators YP_002473590.1 homology (Evalue<1e-4) to COG0577 [R] ABC-type transport systems, involved in lipoprotein release, permease components YP_002473591.1 homology (Evalue<1e-4) to COG1136 [R] ABC-type transport systems, involved in lipoprotein release, ATPase components YP_002473592.1 homology (Evalue<1e-4) to COG0642 [T] Signal transduction histidine kinase YP_002473593.1 homology (Evalue<1e-4) to COG0745 [TK] Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain YP_002473596.1 homology (Evalue<1e-4) to COG0577 [R] ABC-type transport systems, involved in lipoprotein release, permease components YP_002473597.1 homology (Evalue<1e-4) to COG1136 [R] ABC-type transport systems, involved in lipoprotein release, ATPase components YP_002473598.1 homology (Evalue<1e-4) to COG0642 [T] Signal transduction histidine kinase YP_002473599.1 homology (Evalue<1e-4) to COG0745 [TK] Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain YP_002473600.1 homology (Evalue<1e-4) to COG3666 [L] Transposase YP_002473601.1 homology (Evalue<1e-4) to COG2265 [J] SAM-dependent methyltransferases related to tRNA (uracil-5-)-methyltransferase YP_002473602.1 homology (Evalue<1e-4) to COG0469 [G] Pyruvate kinase YP_002473603.1 catalyzes the formation of D-fructose 1,6-bisphosphate from D-fructose 6-phosphate in glycolysis YP_002473604.1 catalyzes DNA-template-directed extension of the 3'-end of a DNA strand by one nucleotide at a time. Proposed to be responsible for the synthesis of the lagging strand. In the low GC gram positive bacteria this enzyme is less processive and more error prone than its counterpart in other bacteria. YP_002473605.1 homology (Evalue<1e-4) to COG0517 [R] CBS domains YP_002473606.1 homology (Evalue<1e-4) to COG1481 [S] Uncharacterized BCR YP_002473607.1 homology (Evalue<1e-4) to COG0391 [S] Uncharacterized ACR YP_002473608.1 homology (Evalue<1e-4) to COG1660 [R] Predicted P-loop-containing kinase YP_002473609.1 catalyzes the reduction of UDP-N-acetylglucosamine enolpyruvate to form UDP-N-acetylmuramate in peptidoglycan biosynthesis YP_002473610.1 The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrC both incises the 5' and 3' sides of the lesion. The N-terminal half is responsible for the 3' incision and the C-terminal half is responsible for the 5' incision YP_002473611.1 homology (Evalue<1e-4) to COG1988 [R] Predicted membrane-bound metal-dependent hydrolases YP_002473612.1 homology (Evalue<1e-4) to COG0768 [M] Cell division protein FtsI/penicillin-binding protein 2 YP_002473613.1 homology (Evalue<1e-4) to COG0772 [D] Bacterial cell division membrane protein YP_002473614.1 homology (Evalue<1e-4) to COG1716 [T] FHA-domain-containing proteins YP_002473615.1 The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 uvrA and 2 uvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by uvrB, the uvrA molecules dissociate YP_002473616.1 The UvrABC repair system catalyzes the recognition and processing of DNA lesions. The beta-hairpin of the Uvr-B subunit is inserted between the strands, where it probes for the presence of a lesion YP_002473617.1 homology (Evalue<1e-4) to COG0265 [O] Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain YP_002473618.1 homology (Evalue<1e-4) to COG0793 [M] Periplasmic protease YP_002473619.1 homology (Evalue<1e-4) to COG2177 [D] Cell division protein YP_002473620.1 homology (Evalue<1e-4) to COG2884 [D] Predicted ATPase involved in cell division YP_002473621.1 homology (Evalue<1e-4) to COG0021 [G] Transketolase YP_002473622.1 homology (Evalue<1e-4) to COG0021 [G] Transketolase YP_002473623.1 homology (Evalue<1e-4) to COG2337 [T] Growth inhibitor YP_002473624.1 homology (Evalue<1e-4) to COG0864 [K] Predicted transcriptional regulators containing the CopG/Arc/MetJ DNA-binding domain and a metal-binding domain YP_002473625.1 converts L-alanine to D-alanine which is used in cell wall biosynthesis; binds one pyridoxal phosphate per monomer; forms a homodimer YP_002473626.1 homology (Evalue<1e-4) to COG1557 [S] Predicted membrane protein YP_002473627.1 homology (Evalue<1e-4) to COG0063 [G] Predicted sugar kinase YP_002473628.1 Catalyzes the formation of holo-ACP, which mediates the essential transfer of acyl fatty acid intermediates during the biosynthesis of fatty acids and lipids YP_002473630.1 homology (Evalue<1e-4) to COG2190 [G] Phosphotransferase system IIA components YP_002473631.1 homology (Evalue<1e-4) to COG3773 [M] Cell wall hydrolyses involved in spore germination YP_002473632.1 homology (Evalue<1e-4) to COG2239 [P] Mg/Co/Ni transporter MgtE (contains CBS domain) YP_002473634.1 similar to YegS from E. coli YP_002473635.1 homology (Evalue<1e-4) to COG0517 [R] CBS domains YP_002473636.1 homology (Evalue<1e-4) to COG0398 [S] Uncharacterized ACR YP_002473637.1 homology (Evalue<1e-4) to COG1183 [I] Phosphatidylserine synthase YP_002473639.1 homology (Evalue<1e-4) to COG0427 [C] Acetyl-CoA hydrolase YP_002473640.1 homology (Evalue<1e-4) to COG0572 [F] Uridine kinase YP_002473641.1 homology (Evalue<1e-4) to COG2323 [S] Predicted membrane protein YP_002473643.1 homology (Evalue<1e-4) to COG0191 [G] Fructose/tagatose bisphosphate aldolase YP_002473644.1 homology (Evalue<1e-4) to COG1437 [F] Adenylate cyclase, class 2 (thermophilic) YP_002473646.1 homology (Evalue<1e-4) to COG2214 [O] Molecular chaperones, DnaJ class YP_002473648.1 leucine--tRNA ligase; LeuRS; class-I aminoacyl-tRNA synthetase; charges leucine by linking carboxyl group to alpha-phosphate of ATP and then transfers aminoacyl-adenylate to its tRNA; due to the large number of codons that tRNA(Leu) recognizes, the leucyl-tRNA synthetase does not recognize the anticodon loop of the tRNA, but instead recognition is dependent on a conserved discriminator base A37 and a long arm; an editing domain hydrolyzes misformed products; in Methanothermobacter thermautotrophicus this enzyme associates with prolyl-tRNA synthetase YP_002473649.1 homology (Evalue<1e-4) to COG2357 [S] Uncharacterized BCR YP_002473650.1 homology (Evalue<1e-4) to COG1655 [S] Uncharacterized BCR YP_002473651.1 homology (Evalue<1e-4) to COG1768 [R] Predicted phosphohydrolases YP_002473652.1 homology (Evalue<1e-4) to COG2257 [S] Uncharacterized BCR homologous to the cytoplasmic domain of flagellar protein FhlB YP_002473653.1 homology (Evalue<1e-4) to COG1196 [D] Chromosome segregation ATPases YP_002473654.1 homology (Evalue<1e-4) to COG3601 [S] Uncharacterized membrane protein YP_002473655.1 homology (Evalue<1e-4) to COG2183 [R] Predicted RNA binding protein, contains S1 domain YP_002473656.1 homology (Evalue<1e-4) to COG0577 [R] ABC-type transport systems, involved in lipoprotein release, permease components YP_002473657.1 homology (Evalue<1e-4) to COG1136 [R] ABC-type transport systems, involved in lipoprotein release, ATPase components YP_002473658.1 homology (Evalue<1e-4) to COG0845 [Q] Membrane-fusion protein YP_002473660.1 catalyzes the release of newly synthesized polypeptide chains at the stop codons UAA and UGA YP_002473661.1 functions in protein export; can interact with acidic membrane phospholipids and the SecYEG protein complex; binds to preproteins; binds to ATP and undergoes a conformational change to promote membrane insertion of SecA/bound preprotein; ATP hydrolysis appears to drive release of the preprotein from SecA and deinsertion of SecA from the membrane; additional proteins SecD/F/YajC aid SecA recycling; exists in an equilibrium between monomers and dimers; may possibly form higher order oligomers; proteins in this cluster correspond SecA1; SecA2 is not essential and seems to play a role in secretion of a subset of proteins YP_002473662.1 homology (Evalue<1e-4) to COG1544 [J] Ribosome-associated protein Y (PSrp-1) YP_002473663.1 catalyzes the transamination of the branched-chain amino acids to their respective alpha-keto acids YP_002473664.1 homology (Evalue<1e-4) to COG0582 [L] Integrase YP_002473665.1 homology (Evalue<1e-4) to COG3594 [G] Fucose 4-O-acetylase and related acetyltransferases YP_002473667.1 homology (Evalue<1e-4) to COG0562 [M] UDP-galactopyranose mutase YP_002473668.1 homology (Evalue<1e-4) to COG0463 [M] Glycosyltransferases involved in cell wall biogenesis YP_002473669.1 homology (Evalue<1e-4) to COG0671 [I] Membrane-associated phospholipid phosphatase YP_002473671.1 homology (Evalue<1e-4) to COG1396 [K] Predicted transcriptional regulators YP_002473673.1 homology (Evalue<1e-4) to COG0348 [C] Polyferredoxin YP_002473674.1 homology (Evalue<1e-4) to COG0701 [R] Predicted permeases YP_002473675.1 homology (Evalue<1e-4) to COG0526 [OC] Thiol-disulfide isomerase and thioredoxins YP_002473676.1 homology (Evalue<1e-4) to COG0640 [K] Predicted transcriptional regulators YP_002473678.1 homology (Evalue<1e-4) to COG0745 [TK] Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain YP_002473679.1 homology (Evalue<1e-4) to COG0642 [T] Signal transduction histidine kinase YP_002473681.1 homology (Evalue<1e-4) to COG1237 [R] Metal-dependent hydrolases of the beta-lactamase superfamily II YP_002473682.1 homology (Evalue<1e-4) to COG0157 [H] Nicotinate-nucleotide pyrophosphorylase YP_002473683.1 homology (Evalue<1e-4) to COG0822 [C] NifU homologs involved in Fe-S cluster formation YP_002473684.1 homology (Evalue<1e-4) to COG1342 [R] Predicted DNA-binding proteins YP_002473685.1 homology (Evalue<1e-4) to COG0735 [P] Fe2+/Zn2+ uptake regulation proteins YP_002473686.1 homology (Evalue<1e-4) to COG1433 [S] Uncharacterized ACR YP_002473688.1 homology (Evalue<1e-4) to COG1149 [C] MinD superfamily P-loop ATPase containing an inserted ferredoxin domain YP_002473689.1 homology (Evalue<1e-4) to COG1149 [C] MinD superfamily P-loop ATPase containing an inserted ferredoxin domain YP_002473690.1 homology (Evalue<1e-4) to COG1433 [S] Uncharacterized ACR YP_002473691.1 homology (Evalue<1e-4) to COG0489 [D] ATPases involved in chromosome partitioning YP_002473692.1 homology (Evalue<1e-4) to COG0730 [R] Predicted permeases YP_002473693.1 homology (Evalue<1e-4) to COG0697 [GER] Permeases of the drug/metabolite transporter (DMT) superfamily YP_002473694.1 homology (Evalue<1e-4) to COG0583 [K] Transcriptional regulator YP_002473696.1 homology (Evalue<1e-4) to COG2865 [K] Predicted transcriptional regulator containing an HTH domain and an uncharacterized domain shared with the mammalian protein Schlafen YP_002473699.1 homology (Evalue<1e-4) to COG2606 [S] Uncharacterized ACR YP_002473700.1 homology (Evalue<1e-4) to COG0500 [QR] SAM-dependent methyltransferases YP_002473703.1 homology (Evalue<1e-4) to COG1040 [R] Predicted amidophosphoribosyltransferases YP_002473705.1 homology (Evalue<1e-4) to COG0507 [L] ATP-dependent exoDNAse (exonuclease V), alpha subunit - helicase superfamily I member YP_002473706.1 homology (Evalue<1e-4) to COG2710 [C] Nitrogenase molybdenum-iron protein, alpha and beta chains YP_002473707.1 homology (Evalue<1e-4) to COG2710 [C] Nitrogenase molybdenum-iron protein, alpha and beta chains YP_002473708.1 homology (Evalue<1e-4) to COG0614 [P] ABC-type cobalamin/Fe3+-siderophores transport systems, periplasmic components YP_002473709.1 catalyzes the formation of S-adenosylmethionine from methionine and ATP; methionine adenosyltransferase YP_002473711.1 homology (Evalue<1e-4) to COG1077 [D] HSP70 class molecular chaperones involved in cell morphogenesis YP_002473713.1 homology (Evalue<1e-4) to COG0739 [M] Membrane proteins related to metalloendopeptidases YP_002473714.1 homology (Evalue<1e-4) to COG2385 [D] Sporulation protein and related proteins YP_002473715.1 adds enolpyruvyl to UDP-N-acetylglucosamine as a component of cell wall formation; gram-positive bacteria have 2 copies of MurA which are active YP_002473717.1 produces ATP from ADP in the presence of a proton gradient across the membrane; the epsilon subunit is part of the catalytic core of the ATP synthase complex YP_002473718.1 Produces ATP from ADP in the presence of a proton gradient across the membrane. The beta chain is a regulatory subunit YP_002473719.1 Produces ATP from ADP in the presence of a proton gradient across the membrane. The gamma chain is a regulatory subunit YP_002473720.1 produces ATP from ADP in the presence of a proton gradient across the membrane; the alpha chain is a catalytic subunit YP_002473721.1 Produces ATP from ADP in the presence of a proton gradient across the membrane; the delta subunit is part of the catalytic core of the ATP synthase complex YP_002473722.1 produces ATP from ADP in the presence of a proton gradient across the membrane; subunit B is part of the membrane proton channel YP_002473723.1 produces ATP from ADP in the presence of a proton gradient across the membrane; subunit C is part of the membrane proton channel F0 YP_002473724.1 Produces ATP from ADP in the presence of a proton gradient across the membrane. Subunit A is part of the membrane proton channel F0 YP_002473726.1 Catalyzes the synthesis of acetoacetyl coenzyme A from two molecules of acetyl coenzyme A. It can also act as a thiolase, catalyzing the reverse reaction and generating two-carbon units from the four-carbon product of fatty acid oxidation; in Rhizobia and Ralstonia is involved in PHB biosynthesis YP_002473727.1 Catalyzes the synthesis of acetoacetyl coenzyme A from two molecules of acetyl coenzyme A. It can also act as a thiolase, catalyzing the reverse reaction and generating two-carbon units from the four-carbon product of fatty acid oxidation; in Rhizobia and Ralstonia is involved in PHB biosynthesis YP_002473728.1 Catalyzes the synthesis of acetoacetyl coenzyme A from two molecules of acetyl coenzyme A. It can also act as a thiolase, catalyzing the reverse reaction and generating two-carbon units from the four-carbon product of fatty acid oxidation; in Rhizobia and Ralstonia is involved in PHB biosynthesis YP_002473729.1 homology (Evalue<1e-4) to COG0381 [M] UDP-N-acetylglucosamine 2-epimerase YP_002473730.1 homology (Evalue<1e-4) to COG0472 [M] UDP-N-acetylmuramyl pentapeptide phosphotransferase/UDP-N- acetylglucosamine-1-phosphate transferase YP_002473731.1 homology (Evalue<1e-4) to COG2131 [F] Deoxycytidylate deaminase YP_002473732.1 Catalyzes the formation of uracil and 5-phospho-alpha-D-ribosy 1-diphosphate from UMP and diphosphate YP_002473733.1 catalyzes the interconversion of ribose 5-phosphate to ribulose 5-phosphate; enzyme from E. coli shows allose 6-phosphate isomerase activity YP_002473734.1 homology (Evalue<1e-4) to COG0394 [T] Protein-tyrosine-phosphatase YP_002473735.1 homology (Evalue<1e-4) to COG0009 [J] translation factor (SUA5) YP_002473736.1 homology (Evalue<1e-4) to COG0428 [P] Predicted divalent heavy-metal cations transporter YP_002473738.1 recognizes the termination signals UAG and UAA during protein translation a specificity which is dependent on amino acid residues residing in loops of the L-shaped tRNA-like molecule of RF1; this protein is similar to release factor 2 YP_002473739.1 homology (Evalue<1e-4) to COG2890 [J] Predicted rRNA or tRNA methylase YP_002473741.1 homology (Evalue<1e-4) to COG0840 [N] Methyl-accepting chemotaxis protein YP_002473742.1 homology (Evalue<1e-4) to COG0254 [J] Ribosomal protein L31 YP_002473743.1 An RNA-DNA helicase that actively releases nascent mRNAs from paused transcription complexes YP_002473745.1 CTP synthase; cytidine triphosphate synthetase; catalyzes the ATP-dependent amination of UTP to CTP with either L-glutamine or ammonia as the source of nitrogen; in Escherichia coli this enzyme forms a homotetramer YP_002473748.1 homology (Evalue<1e-4) to COG1011 [R] Predicted hydrolases of the HAD superfamily YP_002473749.1 homology (Evalue<1e-4) to COG0707 [M] UDP-N-acetylglucosamine:LPS N-acetylglucosamine transferase YP_002473751.1 homology (Evalue<1e-4) to COG0531 [E] Amino acid transporters YP_002473753.1 An essential enzyme in the nonmevalonate pathway of isopentenyl diphosphate and dimethylallyl diphosphate biosynthesis YP_002473754.1 catalyze the formation of cyanophycin which may act to store excess nitrogen YP_002473756.1 homology (Evalue<1e-4) to COG1388 [N] LysM-repeat proteins and domains YP_002473760.1 homology (Evalue<1e-4) to COG0438 [M] Predicted glycosyltransferases YP_002473761.1 homology (Evalue<1e-4) to COG0640 [K] Predicted transcriptional regulators YP_002473762.1 homology (Evalue<1e-4) to COG2207 [K] AraC-type DNA-binding domain-containing proteins YP_002473763.1 homology (Evalue<1e-4) to COG1132 [Q] ABC-type multidrug/protein/lipid transport system, ATPase component YP_002473764.1 homology (Evalue<1e-4) to COG1132 [Q] ABC-type multidrug/protein/lipid transport system, ATPase component YP_002473765.1 homology (Evalue<1e-4) to COG2247 [M] cell wall-binding domain YP_002473766.1 homology (Evalue<1e-4) to COG0510 [M] Predicted choline kinase involved in LPS biosynthesis YP_002473769.1 homology (Evalue<1e-4) to COG0438 [M] Predicted glycosyltransferases YP_002473770.1 homology (Evalue<1e-4) to COG1653 [G] Sugar-binding periplasmic proteins/domains YP_002473771.1 homology (Evalue<1e-4) to COG0535 [R] Predicted Fe-S oxidoreductases YP_002473772.1 responsible for recognizing base lesions in the genome and initiating base excision DNA repair YP_002473773.1 homology (Evalue<1e-4) to COG2827 [L] Predicted endonuclease containing a URI domain YP_002473774.1 homology (Evalue<1e-4) to COG0836 [M] Mannose-1-phosphate guanylyltransferase YP_002473775.1 homology (Evalue<1e-4) to COG1112 [L] Superfamily I DNA and RNA helicases and helicase subunits YP_002473776.1 homology (Evalue<1e-4) to COG1309 [K] Transcriptional regulator YP_002473777.1 homology (Evalue<1e-4) to COG0574 [G] Phosphoenolpyruvate synthase/pyruvate phosphate dikinase YP_002473778.1 homology (Evalue<1e-4) to COG0586 [S] Uncharacterized membrane-associated protein YP_002473779.1 homology (Evalue<1e-4) to COG1609 [K] Transcriptional regulators YP_002473780.1 IleRS; catalyzes the formation of isoleucyl-tRNA(Ile) from isoleucine and tRNA(Ile); since isoleucine and other amino acids such as valine are similar, there are additional editing function in this enzyme; one is involved in hydrolysis of activated valine-AMP and the other is involved in deacylation of mischarged Val-tRNA(Ile); there are two active sites, one for aminoacylation and one for editing; class-I aminoacyl-tRNA synthetase family type 2 subfamily; some organisms carry two different copies of this enzyme; in some organisms, the type 2 subfamily is associated with resistance to the antibiotic pseudomonic acid (mupirocin) YP_002473781.1 homology (Evalue<1e-4) to COG0860 [M] N-acetylmuramoyl-L-alanine amidase YP_002473782.1 homology (Evalue<1e-4) to COG2220 [R] Predicted Zn-dependent hydrolases of the beta-lactamase fold YP_002473783.1 homology (Evalue<1e-4) to COG0640 [K] Predicted transcriptional regulators YP_002473784.1 homology (Evalue<1e-4) to COG0602 [O] Organic radical activating enzymes YP_002473785.1 Catalyzes the reduction of nucleoside 5'-triphosphates to 2'-deoxynucleoside 5'-triphosphates YP_002473786.1 homology (Evalue<1e-4) to COG1141 [C] Ferredoxin 1 YP_002473789.1 homology (Evalue<1e-4) to COG0532 [J] Translation initiation factor 2 (GTPase) YP_002473790.1 catalyzes the transfer of a total of four methyl groups from S-adenosyl-l-methionine (S-AdoMet) to two adjacent adenosine bases A1518 and A1519 in 16S rRNA; mutations in ksgA causes resistance to the translation initiation inhibitor kasugamycin YP_002473791.1 homology (Evalue<1e-4) to COG1658 [L] Small primase-like proteins (Toprim domain) YP_002473792.1 homology (Evalue<1e-4) to COG3584 [S] Uncharacterized BCR YP_002473793.1 homology (Evalue<1e-4) to COG0084 [L] Mg-dependent DNase YP_002473794.1 methionine--tRNA ligase; MetRS; adds methionine to tRNA(Met) with cleavage of ATP to AMP and diphosphate; some MetRS enzymes form dimers depending on a C-terminal domain that is also found in other proteins such as Trbp111 in Aquifex aeolicus and the cold-shock protein CsaA from Bacillus subtilis while others do not; four subfamilies exist based on sequence motifs and zinc content YP_002473795.1 homology (Evalue<1e-4) to COG1573 [L] Uracil-DNA glycosylase YP_002473796.1 homology (Evalue<1e-4) to COG0700 [S] Uncharacterized membrane protein YP_002473797.1 homology (Evalue<1e-4) to COG2715 [R] Uncharacterized membrane protein, required for spore maturation in B.subtilis. YP_002473800.1 homology (Evalue<1e-4) to COG0726 [G] Predicted xylanase/chitin deacetylase YP_002473801.1 homology (Evalue<1e-4) to COG0245 [I] 2C-methyl-D-erythritol 2,4-cyclodiphosphate synthase YP_002473803.1 homology (Evalue<1e-4) to COG1705 [N] Flagellum-specific muramidase YP_002473804.1 homology (Evalue<1e-4) to COG1842 [I] Phage shock protein A (IM30), suppresses sigma54-dependent transcription YP_002473807.1 homology (Evalue<1e-4) to COG2033 [C] Desulfoferrodoxin YP_002473808.1 homology (Evalue<1e-4) to COG1592 [C] Rubrerythrin YP_002473809.1 homology (Evalue<1e-4) to COG0617 [J] tRNA nucleotidyltransferase/poly(A) polymerase YP_002473810.1 homology (Evalue<1e-4) to COG2002 [K] Regulators of stationary/sporulation gene expression YP_002473811.1 homology (Evalue<1e-4) to COG0791 [M] Cell wall-associated hydrolases (invasion-associated proteins) YP_002473812.1 homology (Evalue<1e-4) to COG0313 [R] Predicted methyltransferases YP_002473813.1 homology (Evalue<1e-4) to COG0500 [QR] SAM-dependent methyltransferases YP_002473814.1 homology (Evalue<1e-4) to COG1360 [N] Flagellar motor protein YP_002473815.1 homology (Evalue<1e-4) to COG1291 [N] Flagellar motor component YP_002473816.1 homology (Evalue<1e-4) to COG1146 [C] Ferredoxin 3 YP_002473818.1 homology (Evalue<1e-4) to COG1774 [S] Uncharacterized ACR, PSP1 homologs YP_002473819.1 catalyzes the DNA-template-directed extension of the 3'-end of a DNA strand; the delta' subunit seems to interact with the gamma subunit to transfer the beta subunit on the DNA YP_002473821.1 homology (Evalue<1e-4) to COG0125 [F] Thymidylate kinase YP_002473822.1 homology (Evalue<1e-4) to COG1982 [E] Arginine/lysine/ornithine decarboxylases YP_002473824.1 homology (Evalue<1e-4) to COG0598 [P] Mg2+ and Co2+ transporters YP_002473825.1 homology (Evalue<1e-4) to COG1619 [S] Uncharacterized proteins, homologs of microcin C7 resistance protein MccF YP_002473826.1 homology (Evalue<1e-4) to COG0760 [O] Parvulin-like peptidyl-prolyl isomerase YP_002473827.1 Modulates the activities of several enzymes which are inactive in their acetylated form YP_002473828.1 homology (Evalue<1e-4) to COG0075 [E] Serine-pyruvate aminotransferase/archaeal aspartate aminotransferase YP_002473829.1 homology (Evalue<1e-4) to COG1573 [L] Uracil-DNA glycosylase YP_002473831.1 homology (Evalue<1e-4) to COG1363 [G] Cellulase M and related proteins YP_002473832.1 homology (Evalue<1e-4) to COG1363 [G] Cellulase M and related proteins YP_002473833.1 homology (Evalue<1e-4) to COG1363 [G] Cellulase M and related proteins YP_002473835.1 homology (Evalue<1e-4) to COG0111 [E] Phosphoglycerate dehydrogenase and related dehydrogenases YP_002473836.1 homology (Evalue<1e-4) to COG0075 [E] Serine-pyruvate aminotransferase/archaeal aspartate aminotransferase YP_002473837.1 homology (Evalue<1e-4) to COG1145 [C] Ferredoxin 2 YP_002473839.1 homology (Evalue<1e-4) to COG2816 [L] NTP pyrophosphohydrolases containing a Zn-finger, probably nucleic-acid-binding YP_002473840.1 Regulatory factor involved in maltose metabolism YP_002473843.1 involved in a recombinational process of DNA repair, independent of the recBC complex YP_002473844.1 homology (Evalue<1e-4) to COG0718 [S] Uncharacterized BCR YP_002473845.1 catalyzes the DNA-template-directed extension of the 3'-end of a DNA strand; the tau chain serves as a scaffold to help in the dimerizaton of the alpha,epsilon and theta core complex; the gamma chain seems to interact with the delta and delta' subunits to transfer the beta subunit on the DNA YP_002473846.1 in Escherichia coli this enzyme functions in thiamine biosynthesis along with thiFSGI and IscS; with ThiFSG catalyzes the formation of thiazole phosphate from tyrosine, cysteine and 1-deoxy-D-xylulose-5-phosphate; forms a complex with ThiG; contains an iron-sulfur center; in Thermotoga this enzyme has an extra C-terminal domain YP_002473847.1 homology (Evalue<1e-4) to COG0500 [QR] SAM-dependent methyltransferases YP_002473848.1 homology (Evalue<1e-4) to COG1961 [L] Site-specific recombinases, DNA invertase Pin homologs YP_002473850.1 homology (Evalue<1e-4) to COG0542 [O] ATPases with chaperone activity, ATP-binding subunit YP_002473852.1 homology (Evalue<1e-4) to COG3547 [L] Transposase YP_002473855.1 homology (Evalue<1e-4) to COG1961 [L] Site-specific recombinases, DNA invertase Pin homologs YP_002473857.1 homology (Evalue<1e-4) to COG1961 [L] Site-specific recombinases, DNA invertase Pin homologs YP_002473858.1 homology (Evalue<1e-4) to COG2337 [T] Growth inhibitor YP_002473859.1 homology (Evalue<1e-4) to COG1595 [K] DNA-directed RNA polymerase specialized sigma subunits, sigma24 homologs YP_002473860.1 homology (Evalue<1e-4) to COG1725 [K] Predicted transcriptional regulators YP_002473861.1 homology (Evalue<1e-4) to COG1121 [P] ABC-type Mn/Zn transport systems, ATPase component YP_002473864.1 homology (Evalue<1e-4) to COG1668 [C] ABC-type Na+ efflux pump, permease component YP_002473865.1 homology (Evalue<1e-4) to COG1131 [Q] ABC-type multidrug transport system, ATPase component YP_002473866.1 homology (Evalue<1e-4) to COG0642 [T] Signal transduction histidine kinase YP_002473867.1 homology (Evalue<1e-4) to COG0745 [TK] Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain YP_002473869.1 homology (Evalue<1e-4) to COG3741 [E] N-formylglutamate amidohydrolase YP_002473870.1 homology (Evalue<1e-4) to COG0500 [QR] SAM-dependent methyltransferases YP_002473872.1 homology (Evalue<1e-4) to COG3505 [N] Type IV secretory pathway, VirD4 components YP_002473873.1 homology (Evalue<1e-4) to COG3797 [S] Uncharacterized BCR YP_002473875.1 homology (Evalue<1e-4) to COG0790 [R] TPR repeat proteins YP_002473876.1 homology (Evalue<1e-4) to COG0789 [K] Predicted transcriptional regulators YP_002473879.1 homology (Evalue<1e-4) to COG0454 [KR] Histone acetyltransferase HPA2 and related acetyltransferases YP_002473883.1 homology (Evalue<1e-4) to COG0739 [M] Membrane proteins related to metalloendopeptidases YP_002473895.1 homology (Evalue<1e-4) to COG2064 [S] Predicted membrane protein YP_002473897.1 homology (Evalue<1e-4) to COG0630 [N] Type IV secretory pathway, VirB11 components, and related ATPases involved in archaeal flagella biosynthesis YP_002473900.1 homology (Evalue<1e-4) to COG1989 [N] Signal peptidase, cleaves prepilin-like proteins YP_002473901.1 homology (Evalue<1e-4) to COG2088 [M] Uncharacterized protein, involved in the regulation of septum location YP_002473905.1 homology (Evalue<1e-4) to COG0338 [L] Site-specific DNA methylase YP_002473908.1 homology (Evalue<1e-4) to COG0071 [O] Molecular chaperone (small heat shock protein) YP_002473909.1 unwinds double stranded DNA YP_002473910.1 homology (Evalue<1e-4) to COG1067 [O] Predicted ATP-dependent protease YP_002473911.1 in Escherichia coli this protein is wrapped around the base of the L1 stalk YP_002473912.1 homology (Evalue<1e-4) to COG0618 [R] Exopolyphosphatase-related proteins YP_002473915.1 binds as a heterodimer with protein S6 to the central domain of the 16S rRNA; helps stabilize the platform of the 30S subunit YP_002473916.1 homology (Evalue<1e-4) to COG0629 [L] Single-stranded DNA-binding protein YP_002473917.1 binds cooperatively with S18 to the S15-16S complex, allowing platform assembly to continue with S11 and S21 YP_002473919.1 homology (Evalue<1e-4) to COG0668 [M] Small-conductance mechanosensitive channel YP_002473920.1 homology (Evalue<1e-4) to COG0628 [R] Predicted permease YP_002473923.1 homology (Evalue<1e-4) to COG1475 [K] Predicted transcriptional regulators YP_002473924.1 homology (Evalue<1e-4) to COG1192 [D] ATPases involved in chromosome partitioning YP_002473925.1 homology (Evalue<1e-4) to COG3344 [L] Retron-type reverse transcriptase YP_002473926.1 glucose-inhibited division protein B; SAM-dependent methyltransferase; methylates the N7 position of guanosine in position 527 of 16S rRNA YP_002473927.1 GidA; glucose-inhibited cell division protein A; involved in the 5-carboxymethylaminomethyl modification (mnm(5)s(2)U) of the wobble uridine base in some tRNAs YP_002473928.1 in Escherichia coli this protein is involved in the biosynthesis of the hypermodified nucleoside 5-methylaminomethyl-2-thiouridine, which is found in the wobble position of some tRNAs and affects ribosomal frameshifting; shows potassium-dependent dimerization and GTP hydrolysis; also involved in regulation of glutamate-dependent acid resistance and activation of gadE YP_002473929.1 homology (Evalue<1e-4) to COG1847 [R] Predicted RNA-binding protein YP_002473930.1 functions to insert inner membrane proteins into the IM in Escherichia coli; interacts with transmembrane segments; functions in both Sec-dependent and -independent membrane insertion; similar to Oxa1p in mitochondria YP_002473931.1 homology (Evalue<1e-4) to COG0759 [S] Uncharacterized ACR YP_002473932.1 protein component of RNaseP which catalyzes the removal of the 5'-leader sequence from pre-tRNA to produce the mature 5'terminus; this enzyme also cleaves other RNA substrates YP_002473933.1 in Escherichia coli transcription of this gene is enhanced by polyamines