-- dump date 20140619_043310 -- class Genbank::misc_feature -- table misc_feature_note -- id note 508765000001 chromosomal replication initiation protein; Reviewed; Region: dnaA; PRK00149 508765000002 DnaA N-terminal domain; Region: DnaA_N; pfam11638 508765000003 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 508765000004 Walker A motif; other site 508765000005 ATP binding site [chemical binding]; other site 508765000006 Walker B motif; other site 508765000007 arginine finger; other site 508765000008 C-terminal domain of bacterial DnaA proteins. The DNA-binding C-terminal domain of DnaA contains a helix-turn-helix motif that specifically interacts with the DnaA box, a 9-mer motif that occurs repetitively in the replication origin oriC. Multiple...; Region: Bac_DnaA_C; cd06571 508765000009 DnaA box-binding interface [nucleotide binding]; other site 508765000010 DNA polymerase III subunit beta; Validated; Region: PRK05643 508765000011 Beta clamp domain. The beta subunit (processivity factor) of DNA polymerase III holoenzyme, refered to as the beta clamp, forms a ring shaped dimer that encircles dsDNA (sliding clamp) in bacteria. The beta-clamp is structurally similar to the trimeric...; Region: beta_clamp; cd00140 508765000012 putative DNA binding surface [nucleotide binding]; other site 508765000013 dimer interface [polypeptide binding]; other site 508765000014 beta-clamp/clamp loader binding surface; other site 508765000015 beta-clamp/translesion DNA polymerase binding surface; other site 508765000016 S4 domain; Region: S4_2; cl17325 508765000017 recombination protein F; Reviewed; Region: recF; PRK00064 508765000018 ATP-binding cassette domain of RecF; Region: ABC_RecF; cd03242 508765000019 Walker A/P-loop; other site 508765000020 ATP binding site [chemical binding]; other site 508765000021 Q-loop/lid; other site 508765000022 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 508765000023 ABC transporter signature motif; other site 508765000024 Walker B; other site 508765000025 D-loop; other site 508765000026 H-loop/switch region; other site 508765000027 DNA gyrase subunit B; Validated; Region: gyrB; PRK05644 508765000028 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 508765000029 Mg2+ binding site [ion binding]; other site 508765000030 G-X-G motif; other site 508765000031 TopoIIA_Trans_DNA_gyrase: Transducer domain, having a ribosomal S5 domain 2-like fold, of the type found in proteins of the type IIA family of DNA topoisomerases similar to the B subunits of E. coli DNA gyrase and E. coli Topoisomerase IV which are; Region: TopoII_Trans_DNA_gyrase; cd00822 508765000032 anchoring element; other site 508765000033 dimer interface [polypeptide binding]; other site 508765000034 ATP binding site [chemical binding]; other site 508765000035 TOPRIM_TopoIIA_GyrB: topoisomerase-primase (TOPRIM) nucleotidyl transferase/hydrolase domain of the type found in proteins of the type IIA family of DNA topoisomerases similar to the Escherichia coli GyrB subunit. TopoIIA enzymes cut both strands of the...; Region: TOPRIM_TopoIIA_GyrB; cd03366 508765000036 active site 508765000037 putative metal-binding site [ion binding]; other site 508765000038 DNA gyrase B subunit, carboxyl terminus; Region: DNA_gyraseB_C; pfam00986 508765000039 DNA gyrase subunit A; Validated; Region: PRK05560 508765000040 DNA Topoisomerase, subtype IIA; domain A'; bacterial DNA topoisomerase IV (C subunit, ParC), bacterial DNA gyrases (A subunit, GyrA),mammalian DNA toposiomerases II. DNA topoisomerases are essential enzymes that regulate the conformational changes...; Region: TOP4c; cd00187 508765000041 CAP-like domain; other site 508765000042 active site 508765000043 primary dimer interface [polypeptide binding]; other site 508765000044 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 508765000045 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 508765000046 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 508765000047 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 508765000048 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 508765000049 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 508765000050 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 508765000051 Zn2+ binding site [ion binding]; other site 508765000052 Mg2+ binding site [ion binding]; other site 508765000053 Predicted small molecule binding protein (contains 3H domain) [General function prediction only]; Region: COG1827 508765000054 HTH domain; Region: HTH_11; pfam08279 508765000055 3H domain; Region: 3H; pfam02829 508765000056 hydroxyglutarate oxidase; Provisional; Region: PRK11728 508765000057 BFD-like [2Fe-2S] binding domain; Region: Fer2_BFD; pfam04324 508765000058 Protein of unknown function (DUF1667); Region: DUF1667; cl17602 508765000059 T-box leader 508765000060 seryl-tRNA synthetase; Provisional; Region: PRK05431 508765000061 Seryl-tRNA synthetase N-terminal domain; Region: Seryl_tRNA_N; pfam02403 508765000062 Seryl-tRNA synthetase (SerRS) class II core catalytic domain. SerRS is responsible for the attachment of serine to the 3' OH group of ribose of the appropriate tRNA. This domain It is primarily responsible for ATP-dependent formation of the enzyme...; Region: SerRS_core; cd00770 508765000063 dimer interface [polypeptide binding]; other site 508765000064 active site 508765000065 motif 1; other site 508765000066 motif 2; other site 508765000067 motif 3; other site 508765000068 Acetyltransferases, including N-acetylases of ribosomal proteins [Translation, ribosomal structure and biogenesis]; Region: RimL; COG1670 508765000069 Acetyltransferase (GNAT) family; Region: Acetyltransf_1; pfam00583 508765000070 Coenzyme A binding pocket [chemical binding]; other site 508765000071 helicase-exonuclease AddAB, AddB subunit; Region: addB_Gpos; TIGR02773 508765000072 PD-(D/E)XK nuclease superfamily; Region: PDDEXK_1; pfam12705 508765000073 helicase-exonuclease AddAB, AddA subunit, Firmicutes type; Region: addA_Gpos; TIGR02785 508765000074 Part of AAA domain; Region: AAA_19; pfam13245 508765000075 Family description; Region: UvrD_C_2; pfam13538 508765000076 PD-(D/E)XK nuclease superfamily; Region: PDDEXK_1; pfam12705 508765000077 Uncharacterized protein conserved in bacteria [Function unknown]; Region: ErfK; COG1376 508765000078 L,D-transpeptidase catalytic domain; Region: YkuD; pfam03734 508765000079 Protein of unknown function (DUF1189); Region: DUF1189; pfam06691 508765000080 Na+/H+-dicarboxylate symporters [Energy production and conversion]; Region: GltP; COG1301 508765000081 Sodium:dicarboxylate symporter family; Region: SDF; pfam00375 508765000082 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 508765000083 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 508765000084 dimer interface [polypeptide binding]; other site 508765000085 phosphorylation site [posttranslational modification] 508765000086 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 508765000087 ATP binding site [chemical binding]; other site 508765000088 Mg2+ binding site [ion binding]; other site 508765000089 G-X-G motif; other site 508765000090 Integrase [DNA replication, recombination, and repair]; Region: XerC; COG0582 508765000091 phiLC3 phage and phage-related integrases, site-specific recombinases, DNA breaking-rejoining enzymes, C-terminal catalytic domain. This CD includes various bacterial (mainly gram positive) and phage integrases, including those similar to Lactococcus...; Region: INT_phiLC3_C; cd01189 508765000092 Int/Topo IB signature motif; other site 508765000093 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 508765000094 non-specific DNA binding site [nucleotide binding]; other site 508765000095 salt bridge; other site 508765000096 sequence-specific DNA binding site [nucleotide binding]; other site 508765000097 Helix-Turn-Helix DNA binding domain of transcription regulators from the MerR superfamily; Region: HTH_MerR-SF; cl02600 508765000098 DNA binding residues [nucleotide binding] 508765000099 phage/plasmid primase, P4 family, C-terminal domain; Region: primase_Cterm; TIGR01613 508765000100 Phage-related protein [Function unknown]; Region: COG4695; cl01923 508765000101 Caudovirus prohead protease; Region: Peptidase_U35; cl01521 508765000102 phage major capsid protein, HK97 family; Region: major_cap_HK97; TIGR01554 508765000103 Phage capsid family; Region: Phage_capsid; pfam05065 508765000104 Head-Tail Connector Protein gp6 of Bacteriophage HK97 and similar proteins; Region: gp6; cd08054 508765000105 oligomerization interface [polypeptide binding]; other site 508765000106 DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213 508765000107 active site 508765000108 DNA binding site [nucleotide binding] 508765000109 Int/Topo IB signature motif; other site 508765000110 HNH nucleases; Region: HNHc; smart00507 508765000111 active site 508765000112 Phage terminase-like protein, large subunit [General function prediction only]; Region: COG4626 508765000113 Phage head-tail joining protein; Region: Phage_H_T_join; pfam05521 508765000114 RNA polymerase sigma factor, sigma-70 family; Region: sigma70-ECF; TIGR02937 508765000115 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 508765000116 This domain family includes the Enolpyruvate transferase (EPT) family and the RNA 3' phosphate cyclase family (RTPC). These 2 families differ in that EPT is formed by 3 repeats of an alpha-beta structural domain while RTPC has 3 similar repeats...; Region: EPT_RTPC-like; cl00288 508765000117 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 508765000118 DNA binding residues [nucleotide binding] 508765000119 RNA polymerase sigma factor, sigma-70 family; Region: sigma70-ECF; TIGR02937 508765000120 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 508765000121 DNA binding residues [nucleotide binding] 508765000122 Domain of unknown function (DUF1887); Region: DUF1887; pfam09002 508765000123 phosphatidylserine decarboxylase; Provisional; Region: PRK00723 508765000124 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 508765000125 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 508765000126 2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207 508765000127 catalytic loop [active] 508765000128 iron binding site [ion binding]; other site 508765000129 [FeFe] hydrogenase, group A; Region: FeFe_hydrog_A; TIGR02512 508765000130 Iron only hydrogenase large subunit, C-terminal domain; Region: Fe_hyd_lg_C; pfam02906 508765000131 Iron hydrogenase small subunit; Region: Fe_hyd_SSU; pfam02256 508765000132 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 508765000133 haloacid dehalogenase-like hydrolase; Region: Hydrolase_3; pfam08282 508765000134 active site 508765000135 motif I; other site 508765000136 motif II; other site 508765000137 haloacid dehalogenase-like hydrolase; Region: HAD; cl17202 508765000138 ABC transporter ATP-binding protein; Provisional; Region: PRK15064 508765000139 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 508765000140 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 508765000141 ABC transporter; Region: ABC_tran_2; pfam12848 508765000142 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 508765000143 solute carrier 6 subfamily, Fusobacterium nucleatum Tyt1-like; solute-binding domain; Region: SLC6sbd_Tyt1-Like; cd10336 508765000144 Na2 binding site [ion binding]; other site 508765000145 putative substrate binding site 1 [chemical binding]; other site 508765000146 Na binding site 1 [ion binding]; other site 508765000147 putative substrate binding site 2 [chemical binding]; other site 508765000148 channel protein, hemolysin III family; Region: hlyIII; TIGR01065 508765000149 Predicted membrane protein, hemolysin III homolog [General function prediction only]; Region: COG1272 508765000150 Domain of unknown function (DUF1836); Region: DUF1836; pfam08876 508765000151 Predicted ATPase of the ABC class; Region: ABC_ATPase; pfam09818 508765000152 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3314 508765000153 Nucleoside recognition; Region: Gate; pfam07670 508765000154 Four helix bundle sensory module for signal transduction; Region: 4HB_MCP_1; pfam12729 508765000155 Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer); Region: MA; smart00283 508765000156 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 508765000157 dimer interface [polypeptide binding]; other site 508765000158 putative CheW interface [polypeptide binding]; other site 508765000159 gamma-glutamyl kinase; Provisional; Region: PRK05429 508765000160 AAK_G5K_ProB: Glutamate-5-kinase (G5K) catalyzes glutamate-dependent ATP cleavage; G5K transfers the terminal phosphoryl group of ATP to the gamma-carboxyl group of glutamate, in the first and controlling step of proline (and, in mammals, ornithine)...; Region: AAK_G5K_ProB; cd04242 508765000161 nucleotide binding site [chemical binding]; other site 508765000162 homotetrameric interface [polypeptide binding]; other site 508765000163 putative phosphate binding site [ion binding]; other site 508765000164 putative allosteric binding site; other site 508765000165 Gamma-glutamyl phosphate reductase (GPR), aldehyde dehydrogenase families 18 and 19; Region: ALDH_F18-19_ProA-GPR; cd07079 508765000166 gamma-glutamyl phosphate reductase; Region: proA; TIGR00407 508765000167 putative catalytic cysteine [active] 508765000168 Autoinducer synthetase; Region: Autoind_synth; cl17404 508765000169 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 508765000170 Coenzyme A binding pocket [chemical binding]; other site 508765000171 Bacterial PH domain; Region: DUF304; cl01348 508765000172 Bacterial PH domain; Region: DUF304; cl01348 508765000173 Predicted membrane protein [Function unknown]; Region: COG3428 508765000174 Bacterial PH domain; Region: DUF304; pfam03703 508765000175 Short-chain dehydrogenases of various substrate specificities [General function prediction only]; Region: DltE; COG0300 508765000176 classical (c) SDRs; Region: SDR_c; cd05233 508765000177 NAD(P) binding site [chemical binding]; other site 508765000178 active site 508765000179 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 508765000180 haloacid dehalogenase-like hydrolase; Region: Hydrolase_3; pfam08282 508765000181 active site 508765000182 motif I; other site 508765000183 motif II; other site 508765000184 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 508765000185 Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer); Region: MA; smart00283 508765000186 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 508765000187 dimer interface [polypeptide binding]; other site 508765000188 putative CheW interface [polypeptide binding]; other site 508765000189 MCP-signal associated domain; Region: MCPsignal_assoc; pfam13682 508765000190 carbamoyl phosphate synthase small subunit; Reviewed; Region: PRK12564 508765000191 Carbamoyl-phosphate synthase small chain, CPSase domain; Region: CPSase_sm_chain; smart01097 508765000192 Small chain of the glutamine-dependent form of carbamoyl phosphate synthase, CPSase II; Region: GATase1_CPSase; cd01744 508765000193 catalytic site [active] 508765000194 subunit interface [polypeptide binding]; other site 508765000195 carbamoyl phosphate synthase large subunit; Reviewed; Region: carB; PRK05294 508765000196 Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289 508765000197 Carbamoyl-phosphate synthase L chain, ATP binding domain; Region: CPSase_L_D2; pfam02786 508765000198 Carbamoyl-phosphate synthetase large chain, oligomerisation domain; Region: CPSase_L_D3; pfam02787 508765000199 Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289 508765000200 ATP-grasp domain; Region: ATP-grasp_4; cl17255 508765000201 Methylglyoxal synthase-like domain from type II glutamine-dependent carbamoyl phosphate synthetase (CSP). CSP, a CarA and CarB heterodimer, catalyzes the production of carbamoyl phosphate which is subsequently employed in the metabolic pathways...; Region: MGS_CPS_II; cd01424 508765000202 IMP binding site; other site 508765000203 dimer interface [polypeptide binding]; other site 508765000204 interdomain contacts; other site 508765000205 partial ornithine binding site; other site 508765000206 c-di-GMP phosphodiesterase class II (HD-GYP domain) [Signal transduction mechanisms]; Region: COG2206 508765000207 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 508765000208 Zn2+ binding site [ion binding]; other site 508765000209 Mg2+ binding site [ion binding]; other site 508765000210 Glutamine synthetase, catalytic domain; Region: Gln-synt_C; pfam00120 508765000211 glutamate racemase; Provisional; Region: PRK00865 508765000212 cyclophilin: cyclophilin-type peptidylprolyl cis- trans isomerases. This family contains eukaryotic, bacterial and archeal proteins which exhibit a peptidylprolyl cis- trans isomerases activity (PPIase, Rotamase) and in addition bind the...; Region: cyclophilin; cd00317 508765000213 active site 508765000214 Domain of unknown function (DUF3783); Region: DUF3783; pfam12646 508765000215 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 508765000216 non-specific DNA binding site [nucleotide binding]; other site 508765000217 salt bridge; other site 508765000218 sequence-specific DNA binding site [nucleotide binding]; other site 508765000219 Peptidase S24 LexA-like proteins are involved in the SOS response leading to the repair of single-stranded DNA within the bacterial cell. This family includes: the lambda repressor CI/C2 family and related bacterial prophage repressor proteins; LexA (EC...; Region: S24_LexA-like; cd06529 508765000220 Catalytic site [active] 508765000221 Subtilisin-like serine proteases [Posttranslational modification, protein turnover, chaperones]; Region: AprE; COG1404 508765000222 Peptidase S8 family domain in CspA-like proteins; Region: Peptidases_S8_CspA-like; cd07478 508765000223 active site 508765000224 catalytic triad [active] 508765000225 Stage II sporulation protein; Region: SpoIID; pfam08486 508765000226 Putative peptidoglycan-binding domain-containing protein [Cell envelope biogenesis, outer membrane]; Region: COG3409 508765000227 Putative peptidoglycan binding domain; Region: PG_binding_1; pfam01471 508765000228 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 508765000229 FeS/SAM binding site; other site 508765000230 Uncharacterized membrane protein [Function unknown]; Region: COG3949 508765000231 Predicted Fe-S oxidoreductase [General function prediction only]; Region: COG1242 508765000232 2-phosphosulfolactate phosphatase; Provisional; Region: PRK00886 508765000233 Phosphosulfolactate phosphohydrolase and related enzymes [Coenzyme metabolism / General function prediction only]; Region: COG2045 508765000234 Predicted SAM-dependent methyltransferases [General function prediction only]; Region: COG1092 508765000235 Putative RNA-binding Domain in PseudoUridine synthase and Archaeosine transglycosylase; Region: PUA; smart00359 508765000236 Middle domain of the SAM-dependent methyltransferase RlmI and related proteins; Region: RlmI_M_like; cd11572 508765000237 putative RNA binding site [nucleotide binding]; other site 508765000238 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 508765000239 S-adenosylmethionine binding site [chemical binding]; other site 508765000240 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 508765000241 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 508765000242 active site 508765000243 phosphorylation site [posttranslational modification] 508765000244 intermolecular recognition site; other site 508765000245 dimerization interface [polypeptide binding]; other site 508765000246 Transcriptional regulatory protein, C terminal; Region: Trans_reg_C; smart00862 508765000247 DNA binding site [nucleotide binding] 508765000248 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 508765000249 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 508765000250 dimer interface [polypeptide binding]; other site 508765000251 phosphorylation site [posttranslational modification] 508765000252 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 508765000253 ATP binding site [chemical binding]; other site 508765000254 Mg2+ binding site [ion binding]; other site 508765000255 G-X-G motif; other site 508765000256 Polyphosphate(polyP) polymerase domain of yeast vacuolar transport chaperone (VTC) proteins VTC-2, -3 and- 4, and similar proteins; Region: PolyPPase_VTC_like; cd07750 508765000257 putative metal binding residues [ion binding]; other site 508765000258 signature motif; other site 508765000259 dimer interface [polypeptide binding]; other site 508765000260 active site 508765000261 polyP binding site; other site 508765000262 substrate binding site [chemical binding]; other site 508765000263 acceptor-phosphate pocket; other site 508765000264 Uncharacterized membrane protein [Function unknown]; Region: SapB; COG1285 508765000265 MgtC family; Region: MgtC; pfam02308 508765000266 CotH protein; Region: CotH; pfam08757 508765000267 5'-nucleotidase/2',3'-cyclic phosphodiesterase and related esterases [Nucleotide transport and metabolism]; Region: UshA; COG0737 508765000268 Escherichia coli CpdB and related proteins, N-terminal metallophosphatase domain; Region: MPP_CpdB_N; cd07410 508765000269 active site 508765000270 metal binding site [ion binding]; metal-binding site 508765000271 5'-nucleotidase, C-terminal domain; Region: 5_nucleotid_C; pfam02872 508765000272 T-box leader 508765000273 Isoleucyl-tRNA synthetase [Translation, ribosomal structure and biogenesis]; Region: IleS; COG0060 508765000274 catalytic core domain of isoleucyl-tRNA synthetases; Region: IleRS_core; cd00818 508765000275 HIGH motif; other site 508765000276 catalytic core domain of isoleucyl-tRNA synthetases; Region: IleRS_core; cd00818 508765000277 active site 508765000278 KMSKS motif; other site 508765000279 Anticodon-binding domain of archaeal, bacterial, and eukaryotic cytoplasmic isoleucyl tRNA synthetases; Region: Anticodon_Ia_Ile_ABEc; cd07961 508765000280 tRNA binding surface [nucleotide binding]; other site 508765000281 anticodon binding site; other site 508765000282 Transcriptional regulators [Transcription]; Region: PurR; COG1609 508765000283 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 508765000284 DNA binding site [nucleotide binding] 508765000285 domain linker motif; other site 508765000286 Ligand binding domain of the LacI tanscriptional regulator family belonging to the type I periplasmic-binding fold protein superfamily; Region: PBP1_LacI_sugar_binding_like; cd06267 508765000287 dimerization interface [polypeptide binding]; other site 508765000288 ligand binding site [chemical binding]; other site 508765000289 Na+-driven multidrug efflux pump [Defense mechanisms]; Region: NorM; COG0534 508765000290 Subfamily of the multidrug and toxic compound extrusion (MATE)-like proteins similar to Streptococcus aureus MepA; Region: MATE_MepA_like; cd13143 508765000291 Uncharacterized membrane protein, required for spore maturation in B.subtilis. [General function prediction only]; Region: SpmA; COG2715 508765000292 Uncharacterized membrane protein [Function unknown]; Region: SpmB; cl17667 508765000293 Uncharacterized conserved protein [Function unknown]; Region: COG3937 508765000294 2-polyprenylphenol 6-hydroxylase; Region: UbiB; TIGR01982 508765000295 ABC1 family; Region: ABC1; cl17513 508765000296 Lysine riboswitch 508765000297 Na+/H+ antiporter [Energy production and conversion]; Region: NhaC; COG1757 508765000298 Creatinase/Prolidase N-terminal domain; Region: Creatinase_N; pfam01321 508765000299 Xaa-Pro aminopeptidase [Amino acid transport and metabolism]; Region: PepP; COG0006 508765000300 X-Prolyl Aminopeptidase 2. E.C. 3.4.11.9. Also known as X-Pro aminopeptidase, proline aminopeptidase, aminopeptidase P, and aminoacylproline aminopeptidase. Catalyses release of any N-terminal amino acid, including proline, that is linked with proline; Region: APP; cd01085 508765000301 active site 508765000302 psp operon transcriptional activator PspF; Region: phageshock_pspF; TIGR02974 508765000303 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 508765000304 Walker A motif; other site 508765000305 ATP binding site [chemical binding]; other site 508765000306 Walker B motif; other site 508765000307 arginine finger; other site 508765000308 Lysophospholipase [Lipid metabolism]; Region: PldB; COG2267 508765000309 Putative lysophospholipase; Region: Hydrolase_4; pfam12146 508765000310 Major intrinsic protein (MIP) superfamily. Members of the MIP superfamily function as membrane channels that selectively transport water, small neutral molecules, and ions out of and between cells. The channel proteins share a common fold: the N-terminal...; Region: MIP; cd00333 508765000311 amphipathic channel; other site 508765000312 Asn-Pro-Ala signature motifs; other site 508765000313 dihydroxyacetone kinase subunit DhaK; Provisional; Region: PRK14481 508765000314 Dihydroxyacetone kinase [Carbohydrate transport and metabolism]; Region: DAK1; COG2376 508765000315 dihydroxyacetone kinase, phosphoprotein-dependent, L subunit; Region: dha_L_ycgS; TIGR02365 508765000316 phosphotransferase mannnose-specific family component IIA; Provisional; Region: PRK14484 508765000317 active pocket/dimerization site; other site 508765000318 active site 508765000319 phosphorylation site [posttranslational modification] 508765000320 T-box leader 508765000321 methionyl-tRNA synthetase; Reviewed; Region: PRK12267 508765000322 catalytic core domain of methioninyl-tRNA synthetases; Region: MetRS_core; cd00814 508765000323 HIGH motif; other site 508765000324 active site 508765000325 KMSKS motif; other site 508765000326 Anticodon-binding domain of methionyl tRNA synthetases; Region: Anticodon_Ia_Met; cd07957 508765000327 tRNA binding surface [nucleotide binding]; other site 508765000328 anticodon binding site; other site 508765000329 tRNA-binding-domain-containing Escherichia coli methionyl-tRNA synthetase (EcMetRS)-like proteins. This family includes EcMetRS and Aquifex aeolicus Trbp111 (AaTrbp111). This domain has general tRNA binding properties. MetRS aminoacylates methionine...; Region: tRNA_bind_EcMetRS_like; cd02800 508765000330 dimer interface [polypeptide binding]; other site 508765000331 putative tRNA-binding site [nucleotide binding]; other site 508765000332 TatD like proteins; E.coli TatD is a cytoplasmic protein, shown to have magnesium dependent DNase activity; Region: TatD_DNAse; cd01310 508765000333 active site 508765000334 Domain of unknown function (DUF348); Region: DUF348; pfam03990 508765000335 G5 domain; Region: G5; pfam07501 508765000336 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3584 508765000337 ribonuclease M5; Region: 5S_RNA_mat_M5; TIGR00334 508765000338 TOPRIM_ RNase M5_like: The topoisomerase-primase (TOPRIM) nucleotidyl transferase/hydrolase domain found in Ribonuclease M5: (RNase M5) and other small primase-like proteins from bacteria and archaea. RNase M5 catalyzes the maturation of 5S rRNA in low...; Region: TOPRIM_RNase_M5_like; cd01027 508765000339 putative active site [active] 508765000340 putative metal binding site [ion binding]; other site 508765000341 Domain of unknown function (DUF4093); Region: DUF4093; pfam13331 508765000342 16S ribosomal RNA methyltransferase KsgA/Dim1 family protein; Reviewed; Region: ksgA; PRK00274 508765000343 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 508765000344 S-adenosylmethionine binding site [chemical binding]; other site 508765000345 prolipoprotein diacylglyceryl transferase; Reviewed; Region: PRK00052 508765000346 ATPases involved in chromosome partitioning [Cell division and chromosome partitioning]; Region: Mrp; COG0489 508765000347 MRP (Multiple Resistance and pH adaptation) is a homologue of the Fer4_NifH superfamily. Like the other members of the superfamily, MRP contains a ATP-binding domain at the N-termini. It is found in bacteria as a membrane-spanning protein and functions...; Region: MRP-like; cd02037 508765000348 Ferredoxin [Energy production and conversion]; Region: Fer; COG1141 508765000349 Thiamine transporter protein (Thia_YuaJ); Region: Thia_YuaJ; pfam09515 508765000350 Predicted transcriptional regulators [Transcription]; Region: COG1695 508765000351 Transcriptional regulator PadR-like family; Region: PadR; pfam03551 508765000352 EDD domain protein, DegV family; Region: DegV; TIGR00762 508765000353 Uncharacterized protein, DegV family COG1307; Region: DegV; pfam02645 508765000354 anaerobic ribonucleoside triphosphate reductase; Provisional; Region: PRK07111 508765000355 ATP cone domain; Region: ATP-cone; pfam03477 508765000356 Class III ribonucleotide reductase; Region: RNR_III; cd01675 508765000357 effector binding site; other site 508765000358 active site 508765000359 Zn binding site [ion binding]; other site 508765000360 glycine loop; other site 508765000361 trans-homoaconitate synthase; Reviewed; Region: aksA; PRK11858 508765000362 Streptomyces rubellomurinus FrbC and related proteins, catalytic TIM barrel domain; Region: DRE_TIM_NifV; cd07939 508765000363 active site 508765000364 catalytic residues [active] 508765000365 metal binding site [ion binding]; metal-binding site 508765000366 aconitate hydratase; Validated; Region: PRK07229 508765000367 Aconitase catalyzes the reversible isomerization of citrate and isocitrate as part of the TCA cycle; Region: AcnA_Bact; cd01585 508765000368 substrate binding site [chemical binding]; other site 508765000369 ligand binding site [chemical binding]; other site 508765000370 Aconitase swivel domain. Aconitase (aconitate hydratase) catalyzes the reversible isomerization of citrate and isocitrate as part of the TCA cycle. This is the aconitase swivel domain, which undergoes swivelling conformational change in the enzyme...; Region: Aconitase_swivel; cl00215 508765000371 substrate binding site [chemical binding]; other site 508765000372 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 508765000373 metal binding site [ion binding]; metal-binding site 508765000374 active site 508765000375 I-site; other site 508765000376 EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2). The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948 508765000377 anaerobic ribonucleoside-triphosphate reductase activating protein; Region: NrdG; TIGR02491 508765000378 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 508765000379 FeS/SAM binding site; other site 508765000380 Alkyladenine DNA glycosylase catalyzes the first step in base excision repair; Region: AAG; cd00540 508765000381 active site 508765000382 DNA binding site [nucleotide binding] 508765000383 Transcriptional regulators [Transcription]; Region: PurR; COG1609 508765000384 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 508765000385 DNA binding site [nucleotide binding] 508765000386 domain linker motif; other site 508765000387 Ligand binding domain of the LacI tanscriptional regulator family belonging to the type I periplasmic-binding fold protein superfamily; Region: PBP1_LacI_sugar_binding_like; cd06267 508765000388 dimerization interface [polypeptide binding]; other site 508765000389 ligand binding site [chemical binding]; other site 508765000390 alpha,alpha-phosphotrehalase; Region: trehalose_treC; TIGR02403 508765000391 Alpha amylase catalytic domain found in Sucrose isomerases, oligo-1,6-glucosidase (also called isomaltase; sucrase-isomaltase; alpha-limit dextrinase), dextran glucosidase (also called glucan 1,6-alpha-glucosidase), and related proteins; Region: AmyAc_SI_OligoGlu_DGase; cd11333 508765000392 Ca binding site [ion binding]; other site 508765000393 active site 508765000394 catalytic site [active] 508765000395 ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653 508765000396 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; pfam01547 508765000397 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 508765000398 dimer interface [polypeptide binding]; other site 508765000399 conserved gate region; other site 508765000400 putative PBP binding loops; other site 508765000401 ABC-ATPase subunit interface; other site 508765000402 ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395 508765000403 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 508765000404 dimer interface [polypeptide binding]; other site 508765000405 conserved gate region; other site 508765000406 putative PBP binding loops; other site 508765000407 ABC-ATPase subunit interface; other site 508765000408 Bacterial capsule synthesis protein PGA_cap; Region: PGA_cap; smart00854 508765000409 CapA and related proteins, metallophosphatase domain; Region: MPP_CapA; cd07381 508765000410 putative active site [active] 508765000411 putative metal binding site [ion binding]; other site 508765000412 Predicted divalent heavy-metal cations transporter [Inorganic ion transport and metabolism]; Region: COG0428 508765000413 asparaginyl-tRNA synthetase; Validated; Region: asnC; PRK03932 508765000414 EcAsnRS_like_N: N-terminal, anticodon recognition domain of the type found in Escherichia coli asparaginyl-tRNA synthetase (AsnRS) and, in Arabidopsis thaliana and Saccharomyces cerevisiae mitochondrial (mt) AsnRS. This domain is a beta-barrel domain (OB...; Region: EcAsnRS_like_N; cd04318 508765000415 putative dimer interface [polypeptide binding]; other site 508765000416 putative anticodon binding site; other site 508765000417 Asx tRNA synthetase (AspRS/AsnRS) class II core domain. Assignment to class II aminoacyl-tRNA synthetases (aaRS) based upon its structure and the presence of three characteristic sequence motifs in the core domain. This family includes AsnRS as well as...; Region: AsxRS_core; cd00776 508765000418 homodimer interface [polypeptide binding]; other site 508765000419 motif 1; other site 508765000420 motif 2; other site 508765000421 active site 508765000422 motif 3; other site 508765000423 T-box leader 508765000424 Escherichia coli YfcE and related proteins, metallophosphatase domain; Region: MPP_YfcE; cd00841 508765000425 Calcineurin-like phosphoesterase; Region: Metallophos; pfam00149 508765000426 active site 508765000427 metal binding site [ion binding]; metal-binding site 508765000428 homotetramer interface [polypeptide binding]; other site 508765000429 Xaa-Pro aminopeptidase [Amino acid transport and metabolism]; Region: PepP; COG0006 508765000430 Creatinase/Prolidase N-terminal domain; Region: Creatinase_N; pfam01321 508765000431 Similar to Prolidase and Aminopeptidase P. The members of this subfamily presumably catalyse hydrolysis of Xaa-Pro dipeptides and/or release of any N-terminal amino acid, including proline, that is linked with proline; Region: APP-like; cd01092 508765000432 active site 508765000433 UDP-N-acetylmuramate--L-alanine ligase; Provisional; Region: murC; PRK00421 508765000434 Mur ligase family, catalytic domain; Region: Mur_ligase; pfam01225 508765000435 Mur ligase middle domain; Region: Mur_ligase_M; pfam08245 508765000436 Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875 508765000437 pur operon repressor; Provisional; Region: PRK09213 508765000438 Bacterial purine repressor, N-terminal; Region: PuR_N; pfam09182 508765000439 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 508765000440 active site 508765000441 regulatory protein SpoVG; Reviewed; Region: PRK13259 508765000442 bifunctional N-acetylglucosamine-1-phosphate uridyltransferase/glucosamine-1-phosphate acetyltransferase; Provisional; Region: glmU; PRK14354 508765000443 N-terminal domain of bacterial GlmU; Region: GT2_GlmU_N_bac; cd02540 508765000444 Substrate binding site; other site 508765000445 Mg++ binding site; other site 508765000446 N-acetyl-glucosamine-1-phosphate uridyltransferase (GlmU), C-terminal left-handed beta-helix (LbH) acetyltransferase domain: GlmU is also known as UDP-N-acetylglucosamine pyrophosphorylase. It is a bifunctional bacterial enzyme that catalyzes two...; Region: LbH_GlmU_C; cd03353 508765000447 active site 508765000448 substrate binding site [chemical binding]; other site 508765000449 CoA binding site [chemical binding]; other site 508765000450 ribose-phosphate pyrophosphokinase; Provisional; Region: PRK01259 508765000451 N-terminal domain of ribose phosphate pyrophosphokinase; Region: Pribosyltran_N; pfam13793 508765000452 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 508765000453 active site 508765000454 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 508765000455 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 508765000456 active site 508765000457 phosphorylation site [posttranslational modification] 508765000458 intermolecular recognition site; other site 508765000459 dimerization interface [polypeptide binding]; other site 508765000460 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 508765000461 DNA binding site [nucleotide binding] 508765000462 Peptidyl-tRNA hydrolase (PTH) is a monomeric protein that cleaves the ester bond linking the nascent peptide and tRNA when peptidyl-tRNA is released prematurely from the ribosome. This ensures the recycling of peptidyl-tRNAs into tRNAs produced through...; Region: PTH; cd00462 508765000463 putative active site [active] 508765000464 catalytic residue [active] 508765000465 Transcription-repair coupling factor (superfamily II helicase) [DNA replication, recombination, and repair / Transcription]; Region: Mfd; COG1197 508765000466 CarD-like/TRCF domain; Region: CarD_TRCF; smart01058 508765000467 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 508765000468 ATP binding site [chemical binding]; other site 508765000469 putative Mg++ binding site [ion binding]; other site 508765000470 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 508765000471 nucleotide binding region [chemical binding]; other site 508765000472 ATP-binding site [chemical binding]; other site 508765000473 This domain is found in proteins necessary for strand-specific repair in DNA such as TRCF in Escherichia coli; Region: TRCF; smart00982 508765000474 peptidylprolyl isomerase; Provisional; Region: prsA; PRK00059 508765000475 SurA N-terminal domain; Region: SurA_N_3; cl07813 508765000476 PPIC-type PPIASE domain; Region: Rotamase; pfam00639 508765000477 stage V sporulation protein T; Region: spore_V_T; TIGR02851 508765000478 looped-hinge helix DNA binding domain, AbrB family; Region: lp_hng_hel_AbrB; TIGR01439 508765000479 stage V sporulation protein B; Region: spore_V_B; TIGR02900 508765000480 Stage V sporulation protein B, also known as Stage III sporulation protein F, and related proteins; Region: MATE_SpoVB_like; cd13124 508765000481 Protein containing tetrapyrrole methyltransferase domain and MazG-like (predicted pyrophosphatase) domain [General function prediction only]; Region: COG3956 508765000482 N-terminal S-AdoMet dependent methylase domain of Bacillus subtilis YabN and related proteins; Region: YabN_N; cd11723 508765000483 putative SAM binding site [chemical binding]; other site 508765000484 putative homodimer interface [polypeptide binding]; other site 508765000485 Nucleoside Triphosphate Pyrophosphohydrolase (EC 3.6.1.8) N-terminal tandem-domain of MazG proteins from Escherichia coli and bacterial homologs; Region: NTP-PPase_MazG_Nterm; cd11528 508765000486 homodimer interface [polypeptide binding]; other site 508765000487 metal binding site [ion binding]; metal-binding site 508765000488 Nucleoside Triphosphate Pyrophosphohydrolase (EC 3.6.1.8) C-terminal tandem-domain of MazG proteins from Escherichia coli and bacterial homologs' Region: NTP-PPase_MazG_Cterm; cd11529 508765000489 homodimer interface [polypeptide binding]; other site 508765000490 active site 508765000491 putative chemical substrate binding site [chemical binding]; other site 508765000492 metal binding site [ion binding]; metal-binding site 508765000493 Integration host factor (IHF) and HU are small heterodimeric members of the DNABII protein family that bind and bend DNA, functioning as architectural factors in many cellular processes including transcription, site-specific recombination, and...; Region: HU_IHF; cd00591 508765000494 IHF dimer interface [polypeptide binding]; other site 508765000495 IHF - DNA interface [nucleotide binding]; other site 508765000496 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 508765000497 RNA binding surface [nucleotide binding]; other site 508765000498 YabP family; Region: YabP; cl06766 508765000499 Septum formation initiator [Cell division and chromosome partitioning]; Region: COG2919 508765000500 Septum formation initiator; Region: DivIC; pfam04977 508765000501 hypothetical protein; Provisional; Region: PRK05807 508765000502 S1_RPS1_repeat_hs4: Ribosomal protein S1 (RPS1) domain. RPS1 is a component of the small ribosomal subunit thought to be involved in the recognition and binding of mRNA's during translation initiation. The bacterial RPS1 domain architecture consists...; Region: S1_RPS1_repeat_hs4; cd05692 508765000503 RNA binding site [nucleotide binding]; other site 508765000504 stage II sporulation protein E; Region: spore_II_E; TIGR02865 508765000505 Stage II sporulation protein E (SpoIIE); Region: SpoIIE; pfam07228 508765000506 tRNA(Ile)-lysidine synthase MesJ [Cell cycle control, cell division, chromosome partitioning]; Region: MesJ; COG0037 508765000507 N-terminal domain of predicted ATPase of the PP-loop faimly implicated in cell cycle control [Cell division and chromosome partitioning]. This is a subfamily of Adenine nucleotide alpha hydrolases superfamily.Adeninosine nucleotide alpha hydrolases...; Region: PP-ATPase; cd01992 508765000508 Ligand Binding Site [chemical binding]; other site 508765000509 TilS substrate C-terminal domain; Region: TilS_C; smart00977 508765000510 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 508765000511 active site 508765000512 FtsH Extracellular; Region: FtsH_ext; pfam06480 508765000513 ATP-dependent metalloprotease FtsH; Region: FtsH_fam; TIGR01241 508765000514 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 508765000515 Walker A motif; other site 508765000516 ATP binding site [chemical binding]; other site 508765000517 Walker B motif; other site 508765000518 arginine finger; other site 508765000519 Peptidase family M41; Region: Peptidase_M41; pfam01434 508765000520 formate--tetrahydrofolate ligase; Provisional; Region: PRK13505 508765000521 Formyltetrahydrofolate synthetase (FTHFS) catalyzes the ATP-dependent activation of formate ion via its addition to the N10 position of tetrahydrofolate. FTHFS is a highly expressed key enzyme in both the Wood-Ljungdahl pathway of autotrophic CO2...; Region: FTHFS; cd00477 508765000522 Potassium binding sites [ion binding]; other site 508765000523 Cesium cation binding sites [ion binding]; other site 508765000524 pantothenate kinase; Reviewed; Region: PRK13318 508765000525 putative TIM-barrel protein, nifR3 family; Region: nifR3_yhdG; TIGR00737 508765000526 Dihydrouridine synthase-like (DUS-like) FMN-binding domain. Members of this family catalyze the reduction of the 5,6-double bond of a uridine residue on tRNA. Dihydrouridine modification of tRNA is widely observed in prokaryotes and eukaryotes, and also...; Region: DUS_like_FMN; cd02801 508765000527 FMN binding site [chemical binding]; other site 508765000528 active site 508765000529 catalytic residues [active] 508765000530 substrate binding site [chemical binding]; other site 508765000531 Sulfite oxidase (SO) family, molybdopterin binding domain. This molybdopterin cofactor (Moco) binding domain is found in a variety of oxidoreductases, main members of this family are nitrate reductase (NR) and sulfite oxidase (SO). SO catalyzes the...; Region: SO_family_Moco; cl00199 508765000532 transcription elongation factor GreA; Reviewed; Region: greA; PRK00226 508765000533 Transcription elongation factor, N-terminal; Region: GreA_GreB_N; pfam03449 508765000534 Transcription elongation factor, GreA/GreB, C-term; Region: GreA_GreB; pfam01272 508765000535 lysyl-tRNA synthetase; Reviewed; Region: lysS; PRK00484 508765000536 LysRS_N: N-terminal, anticodon recognition domain of lysyl-tRNA synthetases (LysRS). These enzymes are homodimeric class 2b aminoacyl-tRNA synthetases (aaRSs). This domain is a beta-barrel domain (OB fold) involved in binding the tRNA anticodon stem-loop; Region: LysRS_N; cd04322 508765000537 dimer interface [polypeptide binding]; other site 508765000538 putative anticodon binding site; other site 508765000539 Lys_tRNA synthetase (LysRS) class II core domain. Class II LysRS is a dimer which attaches a lysine to the 3' OH group of ribose of the appropriate tRNA. Its assignment to class II aaRS is based upon its structure and the presence of three...; Region: LysRS_core; cd00775 508765000540 motif 1; other site 508765000541 active site 508765000542 motif 2; other site 508765000543 motif 3; other site 508765000544 T-box leader 508765000545 glycyl-tRNA synthetase; Provisional; Region: PRK04173 508765000546 Class II tRNA amino-acyl synthetase-like catalytic core domain. Class II amino acyl-tRNA synthetases (aaRS) share a common fold and generally attach an amino acid to the 3' OH of ribose of the appropriate tRNA. PheRS is an exception in that it...; Region: class_II_aaRS-like_core; cl00268 508765000547 motif 1; other site 508765000548 Glycyl-tRNA synthetase (GlyRS)-like class II core catalytic domain. GlyRS functions as a homodimer in eukaryotes, archaea and some bacteria and as a heterotetramer in the remainder of prokaryotes. It is responsible for the attachment of glycine to the 3...; Region: GlyRS-like_core; cd00774 508765000549 active site 508765000550 motif 2; other site 508765000551 motif 3; other site 508765000552 GlyRS Glycyl-anticodon binding domain. GlyRS belongs to class II aminoacyl-tRNA synthetases (aaRS). This alignment contains the anticodon binding domain, which is responsible for specificity in tRNA-binding, so that the activated amino acid is...; Region: GlyRS_anticodon; cd00858 508765000553 anticodon binding site; other site 508765000554 UDP-N-acetylmuramoyl-L-alanyl-D-glutamate synthetase; Provisional; Region: murD; PRK01710 508765000555 Medium chain reductase/dehydrogenase (MDR)/zinc-dependent alcohol dehydrogenase-like family; Region: MDR; cl16912 508765000556 Mur ligase middle domain; Region: Mur_ligase_M; pfam08245 508765000557 Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875 508765000558 Mg2+ and Co2+ transporters [Inorganic ion transport and metabolism]; Region: CorA; COG0598 508765000559 uncharacterized bacterial subfamily of the Escherichia coli CorA-Salmonella typhimurium ZntB family; Region: EcCorA_ZntB-like_u2; cd12827 508765000560 Cl binding site [ion binding]; other site 508765000561 oligomer interface [polypeptide binding]; other site 508765000562 Zinc peptidases M18, M20, M28, and M42; Region: Zinc_peptidase_like; cl14876 508765000563 amidohydrolase; Region: amidohydrolases; TIGR01891 508765000564 metal binding site [ion binding]; metal-binding site 508765000565 Inhibitor of sigma-G Gin; Region: Gin; pfam10764 508765000566 Thymidylate kinase [Nucleotide transport and metabolism]; Region: Tmk; COG0125 508765000567 thymidylate kinase; Provisional; Region: PRK13975; cl17243 508765000568 Protein of unknown function (DUF970); Region: DUF970; pfam06153 508765000569 DNA polymerase III subunit delta'; Validated; Region: PRK05564 508765000570 DNA polymerase III subunit delta'; Validated; Region: PRK08485 508765000571 Uncharacterized homolog of PSP1 [Function unknown]; Region: COG1774 508765000572 The HCP family of iron-sulfur proteins includes hybrid cluster protein (HCP), acetyl-CoA synthase (ACS), and carbon monoxide dehydrogenase (CODH), all of which contain [Fe4-S4] metal clusters at their active sites. These proteins have a conserved...; Region: HCP_like; cl14655 508765000573 4Fe-4S dicluster domain; Region: Fer4_7; pfam12838 508765000574 Predicted Zn-dependent hydrolases of the beta-lactamase fold [General function prediction only]; Region: COG2220 508765000575 Beta-lactamase superfamily domain; Region: Lactamase_B_3; pfam13483 508765000576 Firmicute transcriptional repressor of class III stress genes (CtsR); Region: CtsR; pfam05848 508765000577 Modulator of heat shock repressor CtsR, McsA [Signal transduction mechanisms]; Region: COG3880 508765000578 ATP:guanido phosphotransferase; Provisional; Region: PRK01059 508765000579 Phosphagen (guanidino) kinases found in bacteria; Region: bacterial_phosphagen_kinase; cd07930 508765000580 ADP binding site [chemical binding]; other site 508765000581 phosphagen binding site; other site 508765000582 substrate specificity loop; other site 508765000583 ATP-binding subunits of Clp protease and DnaK/DnaJ chaperones [Posttranslational modification, protein turnover, chaperones]; Region: clpA; COG0542 508765000584 Clp amino terminal domain; Region: Clp_N; pfam02861 508765000585 Clp amino terminal domain; Region: Clp_N; pfam02861 508765000586 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 508765000587 Walker A motif; other site 508765000588 ATP binding site [chemical binding]; other site 508765000589 Walker B motif; other site 508765000590 arginine finger; other site 508765000591 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 508765000592 Walker A motif; other site 508765000593 ATP binding site [chemical binding]; other site 508765000594 Walker B motif; other site 508765000595 C-terminal, D2-small domain, of ClpB protein; Region: ClpB_D2-small; smart01086 508765000596 thioredoxin-disulfide reductase; Region: TRX_reduct; TIGR01292 508765000597 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500 508765000598 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 508765000599 NrdH-redoxin (NrdH) family; NrdH is a small monomeric protein with a conserved redox active CXXC motif within a TRX fold, characterized by a glutaredoxin (GRX)-like sequence and TRX-like activity profile. In vitro, it displays protein disulfide reductase...; Region: NrdH; cd02976 508765000600 catalytic residues [active] 508765000601 NrdH-redoxin (NrdH) family; NrdH is a small monomeric protein with a conserved redox active CXXC motif within a TRX fold, characterized by a glutaredoxin (GRX)-like sequence and TRX-like activity profile. In vitro, it displays protein disulfide reductase...; Region: NrdH; cd02976 508765000602 catalytic residues [active] 508765000603 DNA repair protein RadA; Provisional; Region: PRK11823 508765000604 Sms (bacterial radA) DNA repair protein. This protein is not related to archael radA any more than is to other RecA-like NTPases. Sms has a role in recombination and recombinational repair and is responsible for the stabilization or processing of...; Region: Sms; cd01121 508765000605 Walker A motif/ATP binding site; other site 508765000606 ATP binding site [chemical binding]; other site 508765000607 Walker B motif; other site 508765000608 Subunit ChlI of Mg-chelatase; Region: ChlI; pfam13541 508765000609 DNA integrity scanning protein DisA; Provisional; Region: PRK13482 508765000610 DisA bacterial checkpoint controller nucleotide-binding; Region: DisA_N; pfam02457 508765000611 DisA bacterial checkpoint controller linker region; Region: DisA-linker; pfam10635 508765000612 Nucleoside Triphosphate Pyrophosphohydrolase (EC 3.6.1.8) MazG-like domain superfamily; Region: NTP-PPase; cl16941 508765000613 Integral membrane protein (PIN domain superfamily) [General function prediction only]; Region: COG4956 508765000614 PIN domain of Thermus Thermophilus Hb8, uncharacterized Bacillus subtilis YacL, and other bacterial homologs; Region: PIN_YacL; cd09877 508765000615 putative active site [active] 508765000616 CDP-ME synthetase is involved in mevalonate-independent isoprenoid production; Region: CDP-ME_synthetase; cd02516 508765000617 substrate binding site; other site 508765000618 dimer interface; other site 508765000619 T-box leader 508765000620 prolyl-tRNA synthetase; Provisional; Region: PRK09194 508765000621 Prolyl-tRNA synthetase (ProRS) class II core catalytic domain. ProRS is a homodimer. It is responsible for the attachment of proline to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for ATP-dependent...; Region: ProRS_core_prok; cd00779 508765000622 dimer interface [polypeptide binding]; other site 508765000623 motif 1; other site 508765000624 active site 508765000625 motif 2; other site 508765000626 INS is an amino acid-editing domain inserted (INS) into the bacterial class II prolyl-tRNA synthetase (ProRS) however, this CD is not exclusively bacterial. It is also found at the N-terminus of the eukaryotic/archaea-like ProRS's of yeasts and...; Region: ProRS-INS; cd04334 508765000627 putative deacylase active site [active] 508765000628 Class II tRNA amino-acyl synthetase-like catalytic core domain. Class II amino acyl-tRNA synthetases (aaRS) share a common fold and generally attach an amino acid to the 3' OH of ribose of the appropriate tRNA. PheRS is an exception in that it...; Region: class_II_aaRS-like_core; cl00268 508765000629 active site 508765000630 motif 3; other site 508765000631 ProRS Prolyl-anticodon binding domain, short version found predominantly in bacteria. ProRS belongs to class II aminoacyl-tRNA synthetases (aaRS). This alignment contains the anticodon binding domain, which is responsible for specificity in tRNA-binding; Region: ProRS_anticodon_short; cd00861 508765000632 anticodon binding site; other site 508765000633 cysteinyl-tRNA synthetase; Validated; Region: cysS; PRK00260 508765000634 catalytic core domain of cysteinyl tRNA synthetase; Region: CysRS_core; cd00672 508765000635 active site 508765000636 HIGH motif; other site 508765000637 catalytic core domain of cysteinyl tRNA synthetase; Region: CysRS_core; cd00672 508765000638 KMSKS motif; other site 508765000639 Anticodon-binding domain of cysteinyl tRNA synthetases; Region: Anticodon_Ia_Cys; cd07963 508765000640 tRNA binding surface [nucleotide binding]; other site 508765000641 anticodon binding site; other site 508765000642 RIBOc. Ribonuclease III C terminal domain. This group consists of eukaryotic, bacterial and archeal ribonuclease III (RNAse III) proteins. RNAse III is a double stranded RNA-specific endonuclease. Prokaryotic RNAse III is important in...; Region: RIBOc; cd00593 508765000643 dimerization interface [polypeptide binding]; other site 508765000644 active site 508765000645 metal binding site [ion binding]; metal-binding site 508765000646 rRNA methylases [Translation, ribosomal structure and biogenesis]; Region: SpoU; COG0566 508765000647 RNA 2'-O ribose methyltransferase substrate binding; Region: SpoU_sub_bind; pfam08032 508765000648 SpoU rRNA Methylase family; Region: SpoU_methylase; pfam00588 508765000649 YacP-like NYN domain; Region: NYN_YacP; pfam05991 508765000650 RNA polymerase sigma-H factor; Region: spore_sigH; TIGR02859 508765000651 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 508765000652 Sigma-70, region 4; Region: Sigma70_r4_2; pfam08281 508765000653 elongation factor Tu; Reviewed; Region: PRK00049 508765000654 Elongation Factor Tu (EF-Tu) GTP-binding proteins; Region: EF_Tu; cd01884 508765000655 G1 box; other site 508765000656 GEF interaction site [polypeptide binding]; other site 508765000657 GTP/Mg2+ binding site [chemical binding]; other site 508765000658 Switch I region; other site 508765000659 G2 box; other site 508765000660 G3 box; other site 508765000661 Switch II region; other site 508765000662 G4 box; other site 508765000663 G5 box; other site 508765000664 EFTU_II: Elongation factor Tu domain II. Elongation factors Tu (EF-Tu) are three-domain GTPases with an essential function in the elongation phase of mRNA translation. The GTPase center of EF-Tu is in the N-terminal domain (domain I), also known as the...; Region: EFTU_II; cd03697 508765000665 Domain III of elongation factor (EF) Tu. Ef-Tu consists of three structural domains, designated I, II and III. Domain III adopts a beta barrel structure. Domain III is involved in binding to both charged tRNA and binding to elongation factor Ts (EF-Ts); Region: EFTU_III; cd03707 508765000666 Antibiotic Binding Site [chemical binding]; other site 508765000667 SecE/Sec61-gamma subunits of protein translocation complex; Region: SecE; pfam00584 508765000668 transcription antitermination protein NusG; Validated; Region: nusG; PRK05609 508765000669 Bacterial N-Utilization Substance G (NusG) N-terminal (NGN) domain, subgroup 1; Region: NGN_Bact_1; cd09891 508765000670 putative homodimer interface [polypeptide binding]; other site 508765000671 NusG contains an NGN domain at its N-terminus and KOW motif at its C-terminus; Region: KOW_NusG; cd06091 508765000672 heterodimer interface [polypeptide binding]; other site 508765000673 homodimer interface [polypeptide binding]; other site 508765000674 50S ribosomal protein L11; Validated; Region: rplK; PRK00140 508765000675 Ribosomal protein L11. Ribosomal protein L11, together with proteins L10 and L7/L12, and 23S rRNA, form the L7/L12 stalk on the surface of the large subunit of the ribosome. The homologous eukaryotic cytoplasmic protein is also called 60S ribosomal...; Region: Ribosomal_L11; cd00349 508765000676 23S rRNA interface [nucleotide binding]; other site 508765000677 L7/L12 interface [polypeptide binding]; other site 508765000678 putative thiostrepton binding site; other site 508765000679 L25 interface [polypeptide binding]; other site 508765000680 Ribosomal protein L1. The L1 protein, located near the E-site of the ribosome, forms part of the L1 stalk along with 23S rRNA. In bacteria and archaea, L1 functions both as a ribosomal protein that binds rRNA, and as a translation repressor that binds...; Region: Ribosomal_L1; cd00403 508765000681 mRNA/rRNA interface [nucleotide binding]; other site 508765000682 Ribosomal protein L10 leader 508765000683 Ribosomal protein L10 family, L10 subfamily; composed of bacterial 50S ribosomal protein and eukaryotic mitochondrial 39S ribosomal protein, L10. L10 occupies the L7/L12 stalk of the ribosome. The N-terminal domain (NTD) of L10 interacts with L11 protein...; Region: Ribosomal_L10; cd05797 508765000684 23S rRNA interface [nucleotide binding]; other site 508765000685 Interface with L7/L12 ribosomal proteins [polypeptide binding]; other site 508765000686 Ribosomal protein L7/L12. Ribosomal protein L7/L12 refers to the large ribosomal subunit proteins L7 and L12, which are identical except that L7 is acetylated at the N terminus. It is a component of the L7/L12 stalk, which is located at the surface of...; Region: Ribosomal_L7_L12; cd00387 508765000687 core dimer interface [polypeptide binding]; other site 508765000688 peripheral dimer interface [polypeptide binding]; other site 508765000689 L10 interface [polypeptide binding]; other site 508765000690 L11 interface [polypeptide binding]; other site 508765000691 putative EF-Tu interaction site [polypeptide binding]; other site 508765000692 putative EF-G interaction site [polypeptide binding]; other site 508765000693 RNA polymerase beta subunit. RNA polymerases catalyse the DNA dependent polymerization of RNA. Prokaryotes contain a single RNA polymerase compared to three in eukaryotes (not including mitochondrial. and chloroplast polymerases). Each RNA polymerase...; Region: RNA_pol_B_RPB2; cl17585 508765000694 RNA polymerase Rpb2, domain 2; Region: RNA_pol_Rpb2_2; pfam04561 508765000695 RNA polymerase beta subunit. RNA polymerases catalyse the DNA dependent polymerization of RNA. Prokaryotes contain a single RNA polymerase compared to three in eukaryotes (not including mitochondrial. and chloroplast polymerases). Each RNA polymerase...; Region: RNA_pol_B_RPB2; cd00653 508765000696 DNA-directed RNA polymerase subunit beta; Reviewed; Region: rpoB; PRK00405 508765000697 RPB1 interaction site [polypeptide binding]; other site 508765000698 RPB10 interaction site [polypeptide binding]; other site 508765000699 RPB11 interaction site [polypeptide binding]; other site 508765000700 RPB3 interaction site [polypeptide binding]; other site 508765000701 RPB12 interaction site [polypeptide binding]; other site 508765000702 DNA-directed RNA polymerase subunit beta'; Provisional; Region: PRK00566 508765000703 RNA polymerase Rpb1, domain 1; Region: RNA_pol_Rpb1_1; pfam04997 508765000704 RNA polymerase I subunit A N-terminus; Region: RPOLA_N; smart00663 508765000705 RNA polymerase Rpb1, domain 3; Region: RNA_pol_Rpb1_3; pfam04983 508765000706 RNA polymerase Rpb1, domain 4; Region: RNA_pol_Rpb1_4; pfam05000 508765000707 Largest subunit (beta') of Bacterial DNA-dependent RNA polymerase (RNAP), C-terminal domain; Region: RNAP_beta'_C; cd02655 508765000708 Rpb1 (beta') - Rpb6 (omega) interaction site [polypeptide binding]; other site 508765000709 G-loop; other site 508765000710 Largest subunit (beta') of Bacterial DNA-dependent RNA polymerase (RNAP), C-terminal domain; Region: RNAP_beta'_C; cd02655 508765000711 DNA binding site [nucleotide binding] 508765000712 Rpb1 (beta') - Rpb2 (beta) interaction site [polypeptide binding]; other site 508765000713 S12-like family, 30S ribosomal protein S12 subfamily; S12 is located at the interface of the large and small ribosomal subunits of prokaryotes, chloroplasts and mitochondria, where it plays an important role in both tRNA and ribosomal subunit...; Region: Ribosomal_S12; cd03368 508765000714 S17 interaction site [polypeptide binding]; other site 508765000715 S8 interaction site; other site 508765000716 16S rRNA interaction site [nucleotide binding]; other site 508765000717 streptomycin interaction site [chemical binding]; other site 508765000718 23S rRNA interaction site [nucleotide binding]; other site 508765000719 aminoacyl-tRNA interaction site (A-site) [nucleotide binding]; other site 508765000720 30S ribosomal protein S7; Validated; Region: PRK05302 508765000721 elongation factor G; Reviewed; Region: PRK00007 508765000722 Elongation factor G (EF-G) family involved in both the elongation and ribosome recycling phases of protein synthesis; Region: EF-G; cd01886 508765000723 G1 box; other site 508765000724 putative GEF interaction site [polypeptide binding]; other site 508765000725 GTP/Mg2+ binding site [chemical binding]; other site 508765000726 Switch I region; other site 508765000727 G2 box; other site 508765000728 G3 box; other site 508765000729 Switch II region; other site 508765000730 G4 box; other site 508765000731 G5 box; other site 508765000732 EFG_mtEFG_II: this subfamily represents the domain II of elongation factor G (EF-G) in bacteria and, the C-terminus of mitochondrial Elongation factor G1 (mtEFG1) and G2 (mtEFG2)_like proteins found in eukaryotes. During the process of peptide synthesis...; Region: EFG_mtEFG_II; cd04088 508765000733 EFG_mtEFG1_IV: domains similar to domain IV of the bacterial translational elongation factor (EF) EF-G. Included in this group is a domain of mitochondrial Elongation factor G1 (mtEFG1) proteins homologous to domain IV of EF-G. Eukaryotic cells harbor 2...; Region: EFG_mtEFG1_IV; cd01434 508765000734 EFG_mtEFG_C: domains similar to the C-terminal domain of the bacterial translational elongation factor (EF) EF-G. Included in this group is the C-terminus of mitochondrial Elongation factor G1 (mtEFG1) and G2 (mtEFG2) proteins. Eukaryotic cells harbor 2...; Region: EFG_mtEFG_C; cd03713 508765000735 elongation factor Tu; Reviewed; Region: PRK00049 508765000736 Elongation Factor Tu (EF-Tu) GTP-binding proteins; Region: EF_Tu; cd01884 508765000737 G1 box; other site 508765000738 GEF interaction site [polypeptide binding]; other site 508765000739 GTP/Mg2+ binding site [chemical binding]; other site 508765000740 Switch I region; other site 508765000741 G2 box; other site 508765000742 G3 box; other site 508765000743 Switch II region; other site 508765000744 G4 box; other site 508765000745 G5 box; other site 508765000746 EFTU_II: Elongation factor Tu domain II. Elongation factors Tu (EF-Tu) are three-domain GTPases with an essential function in the elongation phase of mRNA translation. The GTPase center of EF-Tu is in the N-terminal domain (domain I), also known as the...; Region: EFTU_II; cd03697 508765000747 Domain III of elongation factor (EF) Tu. Ef-Tu consists of three structural domains, designated I, II and III. Domain III adopts a beta barrel structure. Domain III is involved in binding to both charged tRNA and binding to elongation factor Ts (EF-Ts); Region: EFTU_III; cd03707 508765000748 Antibiotic Binding Site [chemical binding]; other site 508765000749 30S ribosomal protein S10; Reviewed; Region: rpsJ; PRK00596 508765000750 50S ribosomal protein L3; Validated; Region: rplC; PRK00001 508765000751 50S ribosomal protein L4; Provisional; Region: rplD; PRK05319 508765000752 50S ribosomal protein L23; Reviewed; Region: rplW; PRK05738 508765000753 50S ribosomal protein L2; Validated; Region: rplB; PRK09374 508765000754 Ribosomal Proteins L2, RNA binding domain; Region: Ribosomal_L2; pfam00181 508765000755 Ribosomal Proteins L2, C-terminal domain; Region: Ribosomal_L2_C; pfam03947 508765000756 30S ribosomal protein S19; Reviewed; Region: rpsS; PRK00357 508765000757 Ribosomal protein L22/L17e. L22 (L17 in eukaryotes) is a core protein of the large ribosomal subunit. It is the only ribosomal protein that interacts with all six domains of 23S rRNA, and is one of the proteins important for directing the proper...; Region: Ribosomal_L22; cd00336 508765000758 putative translocon binding site; other site 508765000759 protein-rRNA interface [nucleotide binding]; other site 508765000760 30S ribosomal protein S3; Reviewed; Region: rpsC; PRK00310 508765000761 K homology RNA-binding (KH) domain of the prokaryotic 30S small ribosomal subunit protein S3. S3 is part of the head region of the 30S ribosomal subunit and is believed to interact with mRNA as it threads its way from the latch into the channel. The KH...; Region: 30S_S3_KH; cd02412 508765000762 G-X-X-G motif; other site 508765000763 Ribosomal protein S3, C-terminal domain; Region: Ribosomal_S3_C; pfam00189 508765000764 Ribosomal_L16_L10e: L16 is an essential protein in the large ribosomal subunit of bacteria, mitochondria, and chloroplasts. Large subunits that lack L16 are defective in peptidyl transferase activity, peptidyl-tRNA hydrolysis activity, association with...; Region: Ribosomal_L16_L10e; cd01433 508765000765 23S rRNA interface [nucleotide binding]; other site 508765000766 5S rRNA interface [nucleotide binding]; other site 508765000767 putative antibiotic binding site [chemical binding]; other site 508765000768 L25 interface [polypeptide binding]; other site 508765000769 L27 interface [polypeptide binding]; other site 508765000770 Ribosomal L29 protein/HIP. L29 is a protein of the large ribosomal Subunit. A homolog, called heparin/heparan sulfate interacting protein (HIP), has also been identified in mammals. L29 is located on the surface of the large ribosomal subunit, where it...; Region: Ribosomal_L29_HIP; cd00427 508765000771 23S rRNA interface [nucleotide binding]; other site 508765000772 putative translocon interaction site; other site 508765000773 signal recognition particle (SRP54) interaction site; other site 508765000774 L23 interface [polypeptide binding]; other site 508765000775 trigger factor interaction site; other site 508765000776 30S ribosomal protein S17; Reviewed; Region: rpsQ; PRK05610 508765000777 50S ribosomal protein L14; Validated; Region: rplN; PRK05483 508765000778 50S ribosomal protein L24; Reviewed; Region: rplX; PRK00004 508765000779 KOW motif of Ribosomal Protein L26; Region: KOW_RPL26; cd06089 508765000780 RNA binding site [nucleotide binding]; other site 508765000781 50S ribosomal protein L5; Validated; Region: rplE; PRK00010 508765000782 Ribosomal protein L5; Region: Ribosomal_L5; pfam00281 508765000783 ribosomal L5P family C-terminus; Region: Ribosomal_L5_C; pfam00673 508765000784 30S ribosomal protein S14; Reviewed; Region: rpsN; PRK08061 508765000785 30S ribosomal protein S8; Validated; Region: rpsH; PRK00136 508765000786 50S ribosomal protein L6; Validated; Region: rplF; PRK05498 508765000787 Ribosomal protein L6; Region: Ribosomal_L6; pfam00347 508765000788 Ribosomal protein L6; Region: Ribosomal_L6; pfam00347 508765000789 Ribosomal L18/L5e: L18 (L5e) is a ribosomal protein found in the central protuberance (CP) of the large subunit. L18 binds 5S rRNA and induces a conformational change that stimulates the binding of L5 to 5S rRNA. Association of 5S rRNA with 23S rRNA...; Region: Ribosomal_L18_L5e; cd00432 508765000790 5S rRNA interface [nucleotide binding]; other site 508765000791 L27 interface [polypeptide binding]; other site 508765000792 23S rRNA interface [nucleotide binding]; other site 508765000793 L5 interface [polypeptide binding]; other site 508765000794 30S ribosomal protein S5; Validated; Region: rpsE; PRK00550 508765000795 Ribosomal protein S5, N-terminal domain; Region: Ribosomal_S5; pfam00333 508765000796 Ribosomal protein S5, C-terminal domain; Region: Ribosomal_S5_C; pfam03719 508765000797 Ribosomal protein L30, which is found in eukaryotes and prokaryotes but not in archaea, is one of the smallest ribosomal proteins with a molecular mass of about 7kDa. L30 binds the 23SrRNA as well as the 5S rRNA and is one of five ribosomal proteins that...; Region: Ribosomal_L30; cd01658 508765000798 23S rRNA binding site [nucleotide binding]; other site 508765000799 50S ribosomal protein L15; Reviewed; Region: rplO; PRK05592 508765000800 preprotein translocase subunit SecY; Reviewed; Region: secY; PRK09204 508765000801 SecY translocase; Region: SecY; pfam00344 508765000802 adenylate kinase; Reviewed; Region: adk; PRK00279 508765000803 Adenylate kinase (ADK) catalyzes the reversible phosphoryl transfer from adenosine triphosphates (ATP) to adenosine monophosphates (AMP) and to yield adenosine diphosphates (ADP). This enzyme is required for the biosynthesis of ADP and is essential for...; Region: ADK; cd01428 508765000804 AMP-binding site [chemical binding]; other site 508765000805 ATP-AMP (Ap5A)-binding site [chemical binding]; other site 508765000806 Methionine Aminopeptidase 1. E.C. 3.4.11.18. Also known as methionyl aminopeptidase and Peptidase M. Catalyzes release of N-terminal amino acids, preferentially methionine, from peptides and arylamides; Region: MetAP1; cd01086 508765000807 active site 508765000808 KOW motif of Ribosomal Protein L14; Region: KOW_RPL14; cd06088 508765000809 S1_IF1: Translation Initiation Factor IF1, S1-like RNA-binding domain. IF1 contains an S1-like RNA-binding domain, which is found in a wide variety of RNA-associated proteins. Translation initiation includes a number of interrelated steps preceding the...; Region: S1_IF1; cd04451 508765000810 rRNA binding site [nucleotide binding]; other site 508765000811 predicted 30S ribosome binding site; other site 508765000812 50S ribosomal protein L36; Reviewed; Region: rpmJ; PRK00465 508765000813 30S ribosomal protein S13; Validated; Region: rpsM; PRK05179 508765000814 30S ribosomal protein S13; Region: bact_S13; TIGR03631 508765000815 30S ribosomal protein S11; Validated; Region: PRK05309 508765000816 30S ribosomal protein S4; Validated; Region: rpsD; PRK05327 508765000817 Ribosomal protein S4/S9 N-terminal domain; Region: Ribosomal_S4; pfam00163 508765000818 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 508765000819 RNA binding surface [nucleotide binding]; other site 508765000820 DNA-directed RNA polymerase subunit alpha; Provisional; Region: PRK05182 508765000821 N-terminal domain of the Alpha subunit of Bacterial RNA polymerase; Region: RNAP_alpha_NTD; cd06928 508765000822 alphaNTD homodimer interface [polypeptide binding]; other site 508765000823 alphaNTD - beta interaction site [polypeptide binding]; other site 508765000824 alphaNTD - beta' interaction site [polypeptide binding]; other site 508765000825 Bacterial RNA polymerase, alpha chain C terminal domain; Region: RNA_pol_A_CTD; pfam03118 508765000826 50S ribosomal protein L17; Validated; Region: rplQ; PRK05591 508765000827 cobalt transporter ATP-binding subunit; Provisional; Region: PRK13633 508765000828 First domain of the ATP-binding cassette component of cobalt transport system; Region: ABC_cobalt_CbiO_domain1; cd03225 508765000829 Walker A/P-loop; other site 508765000830 ATP binding site [chemical binding]; other site 508765000831 Q-loop/lid; other site 508765000832 ABC transporter signature motif; other site 508765000833 Walker B; other site 508765000834 D-loop; other site 508765000835 H-loop/switch region; other site 508765000836 cobalt transporter ATP-binding subunit; Provisional; Region: cbiO; PRK13637 508765000837 First domain of the ATP-binding cassette component of cobalt transport system; Region: ABC_cobalt_CbiO_domain1; cd03225 508765000838 Walker A/P-loop; other site 508765000839 ATP binding site [chemical binding]; other site 508765000840 Q-loop/lid; other site 508765000841 ABC transporter signature motif; other site 508765000842 Walker B; other site 508765000843 D-loop; other site 508765000844 H-loop/switch region; other site 508765000845 ABC-type cobalt transport system, permease component CbiQ and related transporters [Inorganic ion transport and metabolism]; Region: CbiQ; COG0619 508765000846 tRNA pseudouridine synthase A; Validated; Region: truA; PRK00021 508765000847 Eukaryotic and bacterial pseudouridine synthases similar to E. coli TruA; Region: PseudoU_synth_EcTruA; cd02570 508765000848 dimerization interface 3.5A [polypeptide binding]; other site 508765000849 active site 508765000850 Ribosomal protein L13. Protein L13, a large ribosomal subunit protein, is one of five proteins required for an early folding intermediate of 23S rRNA in the assembly of the large subunit. L13 is situated on the bottom of the large subunit, near the...; Region: Ribosomal_L13; cd00392 508765000851 23S rRNA interface [nucleotide binding]; other site 508765000852 L3 interface [polypeptide binding]; other site 508765000853 30S ribosomal protein S9; Reviewed; Region: rpsI; PRK00132 508765000854 Na+/phosphate symporter [Inorganic ion transport and metabolism]; Region: NptA; COG1283 508765000855 Na+/Pi-cotransporter; Region: Na_Pi_cotrans; pfam02690 508765000856 Na+/Pi-cotransporter; Region: Na_Pi_cotrans; pfam02690 508765000857 PhoU domain; Region: PhoU; pfam01895 508765000858 PhoU domain; Region: PhoU; pfam01895 508765000859 N-acetylmuramoyl-L-alanine amidase [Cell envelope biogenesis, outer membrane]; Region: AmiC; COG0860 508765000860 N-acetylmuramoyl-L-alanine amidase or MurNAc-LAA (also known as peptidoglycan aminohydrolase, NAMLA amidase, NAMLAA, Amidase 3, and peptidoglycan amidase; EC 3.5.1.28) is an autolysin that hydrolyzes the amide bond between N-acetylmuramoyl and L-amino...; Region: MurNAc-LAA; cd02696 508765000861 active site 508765000862 metal binding site [ion binding]; metal-binding site 508765000863 fumarate hydratase; Provisional; Region: PRK06246 508765000864 fumarate hydratase; Provisional; Region: PRK06842 508765000865 Uncharacterized conserved protein [Function unknown]; Region: COG1284 508765000866 Uncharacterized BCR, YitT family COG1284; Region: DUF161; pfam02588 508765000867 Uncharacterized BCR, YitT family COG1284; Region: DUF161; pfam02588 508765000868 Uncharacterized protein conserved in bacteria (DUF2179); Region: DUF2179; pfam10035 508765000869 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 508765000870 TPR motif; other site 508765000871 Tetratricopeptide repeat; Region: TPR_12; pfam13424 508765000872 binding surface 508765000873 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 508765000874 binding surface 508765000875 Tetratricopeptide repeat; Region: TPR_12; pfam13424 508765000876 TPR motif; other site 508765000877 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 508765000878 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 508765000879 active site 508765000880 phosphorylation site [posttranslational modification] 508765000881 intermolecular recognition site; other site 508765000882 dimerization interface [polypeptide binding]; other site 508765000883 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 508765000884 DNA binding site [nucleotide binding] 508765000885 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 508765000886 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 508765000887 dimer interface [polypeptide binding]; other site 508765000888 phosphorylation site [posttranslational modification] 508765000889 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 508765000890 ATP binding site [chemical binding]; other site 508765000891 Mg2+ binding site [ion binding]; other site 508765000892 G-X-G motif; other site 508765000893 ribonucleotide-diphosphate reductase subunit alpha; Validated; Region: PRK07088 508765000894 Class I ribonucleotide reductase; Region: RNR_I; cd01679 508765000895 active site 508765000896 dimer interface [polypeptide binding]; other site 508765000897 catalytic residues [active] 508765000898 effector binding site; other site 508765000899 R2 peptide binding site; other site 508765000900 Ribonucleotide Reductase, R2/beta subunit, ferritin-like diiron-binding domain; Region: RNRR2; cd01049 508765000901 dimer interface [polypeptide binding]; other site 508765000902 putative radical transfer pathway; other site 508765000903 diiron center [ion binding]; other site 508765000904 tyrosyl radical; other site 508765000905 Phosphoenolpyruvate-protein kinase (PTS system EI component in bacteria) [Carbohydrate transport and metabolism]; Region: PtsA; COG1080 508765000906 PEP-utilising enzyme, N-terminal; Region: PEP-utilisers_N; pfam05524 508765000907 PEP-utilising enzyme, mobile domain; Region: PEP-utilizers; pfam00391 508765000908 PEP-utilising enzyme, TIM barrel domain; Region: PEP-utilizers_C; pfam02896 508765000909 Chromate transporter; Region: Chromate_transp; pfam02417 508765000910 Chromate transporter; Region: Chromate_transp; pfam02417 508765000911 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 508765000912 Tetratricopeptide repeat; Region: TPR_16; pfam13432 508765000913 binding surface 508765000914 TPR motif; other site 508765000915 isoaspartyl dipeptidase; Provisional; Region: PRK10657 508765000916 Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281 508765000917 active site 508765000918 Cell Wall Hydrolase; Region: Hydrolase_2; pfam07486 508765000919 Uncharacterized conserved protein [Function unknown]; Region: COG1624 508765000920 DisA bacterial checkpoint controller nucleotide-binding; Region: DisA_N; pfam02457 508765000921 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4856 508765000922 YbbR-like protein; Region: YbbR; pfam07949 508765000923 Uncharacterized FAD-dependent dehydrogenases [General function prediction only]; Region: COG2509 508765000924 phosphate butyryltransferase; Validated; Region: PRK05805 508765000925 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cd00012 508765000926 nucleotide binding site [chemical binding]; other site 508765000927 Acetokinase family; Region: Acetate_kinase; cl17229 508765000928 Mitochondrial biogenesis AIM24; Region: AIM24; pfam01987 508765000929 Trp repressor protein; Region: Trp_repressor; cl17266 508765000930 phosphoglucosamine mutase; Provisional; Region: glmM; PRK14316 508765000931 GlmM is a bacterial phosphoglucosamine mutase (PNGM) that belongs to the alpha-D-phosphohexomutase superfamily. It is required for the interconversion of glucosamine-6-phosphate and glucosamine-1-phosphate in the biosynthetic pathway of...; Region: GlmM; cd05802 508765000932 active site 508765000933 substrate binding site [chemical binding]; other site 508765000934 metal binding site [ion binding]; metal-binding site 508765000935 Phage late control gene D protein (GPD); Region: Phage_GPD; pfam05954 508765000936 Domain of unknown function (DUF4280); Region: DUF4280; pfam14107 508765000937 Phage late control gene D protein (GPD); Region: Phage_GPD; cl15796 508765000938 Pentapeptide repeats (9 copies); Region: Pentapeptide_4; pfam13599 508765000939 Bacterial EndoU nuclease; Region: EndoU_bacteria; pfam14436 508765000940 Bacterial EndoU nuclease; Region: EndoU_bacteria; pfam14436 508765000941 microbial_RNases. Ribonucleases (RNAses) cleave phosphodiester bonds in RNA and are essential for both non-specific RNA degradation and for numerous forms of RNA processing. The alignment contains fungal RNases (U2, T1, F1, Th, Pb, N1, and Ms) and...; Region: microbial_RNases; cl00212 508765000942 active site 508765000943 Leucine Rich repeats (2 copies); Region: LRR_4; pfam12799 508765000944 Leucine Rich repeats (2 copies); Region: LRR_4; pfam12799 508765000945 Leucine Rich repeats (2 copies); Region: LRR_4; pfam12799 508765000946 acetolactate synthase 3 regulatory subunit; Reviewed; Region: ilvH; PRK11895 508765000947 N-terminal ACT domain of the Escherichia coli IlvH-like regulatory subunit of acetohydroxyacid synthase (AHAS); Region: ACT_AHAS; cd04878 508765000948 putative valine binding site [chemical binding]; other site 508765000949 dimer interface [polypeptide binding]; other site 508765000950 Small subunit of acetolactate synthase; Region: ALS_ss_C; pfam10369 508765000951 3-isopropylmalate dehydratase large subunit; Reviewed; Region: PRK00402 508765000952 3-isopropylmalate dehydratase catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate; Region: IPMI; cd01583 508765000953 substrate binding site [chemical binding]; other site 508765000954 ligand binding site [chemical binding]; other site 508765000955 3-isopropylmalate dehydratase small subunit; Reviewed; Region: leuD; PRK00439 508765000956 Aconatase-like swivel domain of 3-isopropylmalate dehydratase and related uncharacterized proteins. 3-isopropylmalate dehydratase catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate...; Region: IPMI_Swivel; cd01577 508765000957 substrate binding site [chemical binding]; other site 508765000958 3-isopropylmalate dehydrogenase; Provisional; Region: PRK00772 508765000959 tartrate dehydrogenase; Provisional; Region: PRK08194 508765000960 dihydroxy-acid dehydratase; Provisional; Region: PRK00911 508765000961 acetolactate synthase 3 catalytic subunit; Reviewed; Region: PRK06048 508765000962 Pyrimidine (PYR) binding domain of POX and related proteins; Region: TPP_PYR_POX_like; cd07035 508765000963 PYR/PP interface [polypeptide binding]; other site 508765000964 dimer interface [polypeptide binding]; other site 508765000965 TPP binding site [chemical binding]; other site 508765000966 Thiamine pyrophosphate enzyme, central domain; Region: TPP_enzyme_M; pfam00205 508765000967 Thiamine pyrophosphate (TPP) family, Acetohydroxyacid synthase (AHAS) subfamily, TPP-binding module; composed of proteins similar to the large catalytic subunit of AHAS. AHAS catalyzes the condensation of two molecules of pyruvate to give the...; Region: TPP_AHAS; cd02015 508765000968 TPP-binding site [chemical binding]; other site 508765000969 dimer interface [polypeptide binding]; other site 508765000970 ketol-acid reductoisomerase; Provisional; Region: PRK05479 508765000971 Acetohydroxy acid isomeroreductase, catalytic domain; Region: IlvN; pfam07991 508765000972 Acetohydroxy acid isomeroreductase, catalytic domain; Region: IlvC; pfam01450 508765000973 The GIY-YIG domain of uncharacterized protein family UPF0213 related to structure-specific endonuclease SLX1; Region: GIY-YIG_UPF0213; cd10456 508765000974 GIY-YIG motif/motif A; other site 508765000975 putative active site [active] 508765000976 putative metal binding site [ion binding]; other site 508765000977 Transcriptional regulators [Transcription]; Region: PurR; COG1609 508765000978 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 508765000979 DNA binding site [nucleotide binding] 508765000980 domain linker motif; other site 508765000981 Ligand-binding domain of uncharacterized transcription regulator ycjW which is a member of the LacI-GalR family repressors; Region: PBP1_ycjW_transcription_regulator_like; cd06294 508765000982 putative dimerization interface [polypeptide binding]; other site 508765000983 putative ligand binding site [chemical binding]; other site 508765000984 alpha,alpha-phosphotrehalase; Region: trehalose_treC; TIGR02403 508765000985 Alpha amylase catalytic domain found in Sucrose isomerases, oligo-1,6-glucosidase (also called isomaltase; sucrase-isomaltase; alpha-limit dextrinase), dextran glucosidase (also called glucan 1,6-alpha-glucosidase), and related proteins; Region: AmyAc_SI_OligoGlu_DGase; cd11333 508765000986 Ca binding site [ion binding]; other site 508765000987 active site 508765000988 catalytic site [active] 508765000989 PTS system, IIBC component; Region: PTS-II-BC-unk1; TIGR02003 508765000990 Phosphotransferase system IIC components, glucose/maltose/N-acetylglucosamine-specific [Carbohydrate transport and metabolism]; Region: PtsG; COG1263 508765000991 PTS_IIB, PTS system, glucose/sucrose specific IIB subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIB_glc; cd00212 508765000992 active site turn [active] 508765000993 phosphorylation site [posttranslational modification] 508765000994 Streptococcus agalactiae RgfB, part of a putative two component signal transduction system, and related proteins; Region: RgfB-like; cd09079 508765000995 putative catalytic site [active] 508765000996 putative metal binding site [ion binding]; other site 508765000997 putative phosphate binding site [ion binding]; other site 508765000998 helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347 508765000999 Winged helix DNA-binding domain; Region: HTH_27; pfam13463 508765001000 Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533 508765001001 Membrane Fusion Protein cluster 2 (function with RND porters); Region: 8a0102; TIGR00999 508765001002 HlyD family secretion protein; Region: HlyD_3; pfam13437 508765001003 Cation/multidrug efflux pump [Defense mechanisms]; Region: AcrB; COG0841 508765001004 Protein export membrane protein; Region: SecD_SecF; cl14618 508765001005 Transglutaminase-like superfamily; Region: Transglut_core; pfam01841 508765001006 glucosamine--fructose-6-phosphate aminotransferase; Reviewed; Region: PRK00331 508765001007 Glutamine amidotransferases class-II (Gn-AT)_GFAT-type. This domain is found at the N-terminus of glucosamine-6P synthase (GlmS, or GFAT in humans). The glutaminase domain catalyzes amide nitrogen transfer from glutamine to the appropriate substrate. In...; Region: GFAT; cd00714 508765001008 glutaminase active site [active] 508765001009 SIS (Sugar ISomerase) domain repeat 1 found in Glucosamine 6-phosphate synthase (GlmS) and Glucosamine-6-phosphate deaminase (GlmD). The SIS domain is found in many phosphosugar isomerases and phosphosugar binding proteins. GlmS contains a N-terminal...; Region: SIS_GlmS_GlmD_1; cd05008 508765001010 dimer interface [polypeptide binding]; other site 508765001011 active site 508765001012 SIS (Sugar ISomerase) domain repeat 2 found in Glucosamine 6-phosphate synthase (GlmS) and Glucosamine-6-phosphate deaminase (GlmD). The SIS domain is found in many phosphosugar isomerases and phosphosugar binding proteins. GlmS contains a N-terminal...; Region: SIS_GlmS_GlmD_2; cd05009 508765001013 dimer interface [polypeptide binding]; other site 508765001014 active site 508765001015 effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038 508765001016 global nitrogen regulator NtcA, cyanobacterial; Region: NtcA_cyano; TIGR03697 508765001017 ligand binding site [chemical binding]; other site 508765001018 flexible hinge region; other site 508765001019 Crp-like helix-turn-helix domain; Region: HTH_Crp_2; pfam13545 508765001020 Na+-driven multidrug efflux pump [Defense mechanisms]; Region: NorM; COG0534 508765001021 Subfamily of the multidrug and toxic compound extrusion (MATE)-like proteins similar to Streptococcus aureus MepA; Region: MATE_MepA_like; cd13143 508765001022 The phosphomannomutase/phosphoglucomutase (PMM/PGM) bifunctional enzyme catalyzes the reversible conversion of 1-phospho to 6-phospho-sugars (e.g. between mannose-1-phosphate and mannose-6-phosphate or glucose-1-phosphate and glucose-6-phosphate) via a...; Region: PMM_PGM; cd03089 508765001023 active site 508765001024 Phosphomannomutase [Carbohydrate transport and metabolism]; Region: {ManB}; COG1109 508765001025 substrate binding site [chemical binding]; other site 508765001026 metal binding site [ion binding]; metal-binding site 508765001027 Kef-type K+ transport systems, membrane components [Inorganic ion transport and metabolism]; Region: KefB; cl10482 508765001028 NhaP-type Na+/H+ and K+/H+ antiporters [Inorganic ion transport and metabolism]; Region: NhaP; COG0025 508765001029 TrkA-C domain; Region: TrkA_C; pfam02080 508765001030 Formate/nitrite transporter; Region: Form_Nir_trans; pfam01226 508765001031 Carbonic anhydrases (CA) are zinc-containing enzymes that catalyze the reversible hydration of carbon dioxide in a two-step mechanism in which the nucleophilic attack of a zinc-bound hydroxide ion on carbon dioxide is followed by the regeneration of an...; Region: beta_CA_cladeD; cd03379 508765001032 active site clefts [active] 508765001033 zinc binding site [ion binding]; other site 508765001034 dimer interface [polypeptide binding]; other site 508765001035 5,10-methenyltetrahydrofolate synthetase; Region: MTHFS_bact; TIGR02727 508765001036 5-formyltetrahydrofolate cyclo-ligase family; Region: 5-FTHF_cyc-lig; pfam01812 508765001037 O-acetylhomoserine sulfhydrylase [Amino acid transport and metabolism]; Region: MET17; COG2873 508765001038 CGS_like: Cystathionine gamma-synthase is a PLP dependent enzyme and catalyzes the committed step of methionine biosynthesis. This pathway is unique to microorganisms and plants, rendering the enzyme an attractive target for the development of...; Region: CGS_like; cd00614 508765001039 homodimer interface [polypeptide binding]; other site 508765001040 substrate-cofactor binding pocket; other site 508765001041 pyridoxal 5'-phosphate binding site [chemical binding]; other site 508765001042 catalytic residue [active] 508765001043 threonyl-tRNA synthetase; Reviewed; Region: thrS; PRK00413 508765001044 TGS _ThrRS_N: ThrRS (threonyl-tRNA Synthetase) is a class II tRNA synthetase that couples threonine to its cognate tRNA. In addition to its catalytic and anticodon-binding domains, ThrRS has an N-terminal TGS domain, named after the ThrRS, GTPase, and...; Region: TGS_ThrRS_N; cd01667 508765001045 Threonyl and Alanyl tRNA synthetase second additional domain; Region: tRNA_SAD; pfam07973 508765001046 Threonyl-tRNA synthetase (ThrRS) class II core catalytic domain. ThrRS is a homodimer. It is responsible for the attachment of threonine to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for ATP-dependent...; Region: ThrRS_core; cd00771 508765001047 active site 508765001048 dimer interface [polypeptide binding]; other site 508765001049 motif 1; other site 508765001050 motif 2; other site 508765001051 motif 3; other site 508765001052 ThrRS Threonyl-anticodon binding domain. ThrRS belongs to class II aminoacyl-tRNA synthetases (aaRS). This alignment contains the anticodon binding domain, which is responsible for specificity in tRNA-binding, so that the activated amino acid is...; Region: ThrRS_anticodon; cd00860 508765001053 anticodon binding site; other site 508765001054 T-box leader 508765001055 HNH nucleases; HNH endonuclease signature which is found in viral, prokaryotic, and eukaryotic proteins. The alignment includes members of the large group of homing endonucleases, yeast intron 1 protein, MutS, as well as bacterial colicins, pyocins, and...; Region: HNHc; cd00085 508765001056 active site 508765001057 Glycerol-3-phosphate responsive antiterminator; Region: G3P_antiterm; cl00852 508765001058 sn-glycerol-3-phosphate transporter; Provisional; Region: glpT; PRK11273 508765001059 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 508765001060 putative substrate translocation pore; other site 508765001061 MECDP_synthase (2-C-methyl-D-erythritol-2,4-cyclodiphosphate synthase), encoded by the ispF gene, catalyzes the formation of 2-C-methyl-D-erythritol 2,4-cyclodiphosphate (MEC) in the non-mevalonate deoxyxylulose (DOXP) pathway for isoprenoid biosynthesis; Region: MECDP_synthase; cd00554 508765001062 homotrimer interaction site [polypeptide binding]; other site 508765001063 zinc binding site [ion binding]; other site 508765001064 CDP-binding sites; other site 508765001065 Anti-sigma factor N-terminus; Region: RsgI_N; pfam12791 508765001066 Predicted xylanase/chitin deacetylase [Carbohydrate transport and metabolism]; Region: CDA1; COG0726 508765001067 Putative catalytic NodB homology domain of PgaB, IcaB, and similar proteins which consist of a deformed (beta/alpha)8 barrel fold with 5- or 6-strands; Region: CE4_NodB_like_5s_6s; cd10918 508765001068 putative active site [active] 508765001069 putative metal binding site [ion binding]; other site 508765001070 Domain of unknown function (DUF4163); Region: DUF4163; pfam13739 508765001071 Protein of unknown function (DUF3298); Region: DUF3298; pfam11738 508765001072 Uncharacterized conserved protein [Function unknown]; Region: COG1284 508765001073 Uncharacterized BCR, YitT family COG1284; Region: DUF161; pfam02588 508765001074 Uncharacterized BCR, YitT family COG1284; Region: DUF161; pfam02588 508765001075 Uncharacterized protein conserved in bacteria (DUF2179); Region: DUF2179; pfam10035 508765001076 biotin synthase; Provisional; Region: PRK07094 508765001077 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 508765001078 FeS/SAM binding site; other site 508765001079 Biotin and Thiamin Synthesis associated domain; Region: BATS; cl06149 508765001080 Cation transporter/ATPase, N-terminus; Region: Cation_ATPase_N; pfam00690 508765001081 Cation transport ATPase [Inorganic ion transport and metabolism]; Region: MgtA; COG0474 508765001082 E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122 508765001083 Putative hydrolase of sodium-potassium ATPase alpha subunit; Region: Hydrolase_like2; pfam13246 508765001084 haloacid dehalogenase-like hydrolase; Region: HAD; pfam12710 508765001085 Cation transporting ATPase, C-terminus; Region: Cation_ATPase_C; pfam00689 508765001086 Transcriptional regulators [Transcription]; Region: FadR; COG2186 508765001087 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 508765001088 DNA-binding site [nucleotide binding]; DNA binding site 508765001089 FCD domain; Region: FCD; pfam07729 508765001090 The electron transfer flavoprotein (ETF) serves as a specific electron acceptor for various mitochondrial dehydrogenases. ETF transfers electrons to the main respiratory chain via ETF-ubiquinone oxidoreductase. ETF is an heterodimer that consists of an...; Region: ETF_beta; cd01714 508765001091 Ligand binding site [chemical binding]; other site 508765001092 Electron transfer flavoprotein domain; Region: ETF; pfam01012 508765001093 Ferredoxin [Energy production and conversion]; Region: NapF; COG1145 508765001094 RPB11 and RPB3 subunits of RNA polymerase; Region: RNAP_RPB11_RPB3; cl11409 508765001095 Electron transfer flavoprotein, alpha subunit [Energy production and conversion]; Region: FixB; COG2025 508765001096 The electron transfer flavoprotein (ETF) serves as a specific electron acceptor for various mitochondrial dehydrogenases. ETF transfers electrons to the main respiratory chain via ETF-ubiquinone oxidoreductase. ETF is an heterodimer that consists of an...; Region: ETF_alpha; cd01715 508765001097 Electron transfer flavoprotein FAD-binding domain; Region: ETF_alpha; pfam00766 508765001098 FAD/FMN-containing dehydrogenases [Energy production and conversion]; Region: GlcD; COG0277 508765001099 FAD binding domain; Region: FAD_binding_4; pfam01565 508765001100 Predicted esterase of the alpha-beta hydrolase superfamily [General function prediction only]; Region: COG4667 508765001101 Hypothetical patatin similar to yjju protein of Escherichia coli; Region: Pat_hypo_Ecoli_yjju_like; cd07208 508765001102 active site 508765001103 nucleophile elbow; other site 508765001104 transcription termination factor Rho; Provisional; Region: rho; PRK09376 508765001105 Mannose-1-phosphate guanylyltransferase [Cell envelope biogenesis, outer membrane]; Region: {ManC}; COG0836 508765001106 GDP-M1P_Guanylyltransferase catalyzes the formation of GDP-Mannose; Region: GDP-M1P_Guanylyltransferase; cd02509 508765001107 Substrate binding site; other site 508765001108 Cupin domain; Region: Cupin_2; cl17218 508765001109 Zinc dependent phospholipase C; Region: Zn_dep_PLPC; pfam00882 508765001110 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 508765001111 dimerization interface [polypeptide binding]; other site 508765001112 putative DNA binding site [nucleotide binding]; other site 508765001113 putative Zn2+ binding site [ion binding]; other site 508765001114 Heavy-metal-associated domain (HMA) is a conserved domain of approximately 30 amino acid residues found in a number of proteins that transport or detoxify heavy metals, for example, the CPx-type heavy metal ATPases and copper chaperones. HMA domain...; Region: HMA; cd00371 508765001115 metal-binding site [ion binding] 508765001116 Cation transport ATPase [Inorganic ion transport and metabolism]; Region: ZntA; COG2217 508765001117 E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122 508765001118 Soluble P-type ATPase [General function prediction only]; Region: COG4087 508765001119 redox-sensing transcriptional repressor Rex; Provisional; Region: PRK05472 508765001120 Putative DNA-binding protein N-terminus; Region: Put_DNA-bind_N; pfam06971 508765001121 CoA binding domain; Region: CoA_binding; pfam02629 508765001122 3-hydroxybutyryl-CoA dehydratase; Validated; Region: PRK05809 508765001123 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 508765001124 substrate binding site [chemical binding]; other site 508765001125 oxyanion hole (OAH) forming residues; other site 508765001126 trimer interface [polypeptide binding]; other site 508765001127 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 508765001128 Short chain acyl-CoA dehydrogenases and eukaryotic short/branched chain acyl-CoA dehydrogenases; Region: SCAD_SBCAD; cd01158 508765001129 FAD binding site [chemical binding]; other site 508765001130 homotetramer interface [polypeptide binding]; other site 508765001131 substrate binding pocket [chemical binding]; other site 508765001132 catalytic base [active] 508765001133 The electron transfer flavoprotein (ETF) serves as a specific electron acceptor for various mitochondrial dehydrogenases. ETF transfers electrons to the main respiratory chain via ETF-ubiquinone oxidoreductase. ETF is an heterodimer that consists of an...; Region: ETF_beta; cd01714 508765001134 Ligand binding site [chemical binding]; other site 508765001135 Electron transfer flavoprotein domain; Region: ETF; pfam01012 508765001136 Electron transfer flavoprotein, alpha subunit [Energy production and conversion]; Region: FixB; COG2025 508765001137 The electron transfer flavoprotein (ETF) serves as a specific electron acceptor for various mitochondrial dehydrogenases. ETF transfers electrons to the main respiratory chain via ETF-ubiquinone oxidoreductase. ETF is an heterodimer that consists of an...; Region: ETF_alpha; cd01715 508765001138 Electron transfer flavoprotein FAD-binding domain; Region: ETF_alpha; pfam00766 508765001139 3-hydroxybutyryl-CoA dehydrogenase; Validated; Region: PRK05808 508765001140 3-hydroxyacyl-CoA dehydrogenase, NAD binding domain; Region: 3HCDH_N; pfam02737 508765001141 3-hydroxyacyl-CoA dehydrogenase, C-terminal domain; Region: 3HCDH; pfam00725 508765001142 Putative redox-active protein (C_GCAxxG_C_C); Region: C_GCAxxG_C_C; cl09920 508765001143 8-oxoguanine DNA glycosylase, N-terminal domain; Region: OGG_N; pfam07934 508765001144 endonuclease III; includes endonuclease III (DNA-(apurinic or apyrimidinic site) lyase), alkylbase DNA glycosidases (Alka-family) and other DNA glycosidases; Region: ENDO3c; cd00056 508765001145 endonuclease III; Region: ENDO3c; smart00478 508765001146 minor groove reading motif; other site 508765001147 helix-hairpin-helix signature motif; other site 508765001148 substrate binding pocket [chemical binding]; other site 508765001149 active site 508765001150 [FeFe] hydrogenase, group B1/B3; Region: FeFe_hydrog_B1; TIGR04105 508765001151 4Fe-4S binding domain; Region: Fer4; pfam00037 508765001152 4Fe-4S binding domain; Region: Fer4; pfam00037 508765001153 Iron only hydrogenase large subunit, C-terminal domain; Region: Fe_hyd_lg_C; pfam02906 508765001154 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 508765001155 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 508765001156 active site 508765001157 phosphorylation site [posttranslational modification] 508765001158 intermolecular recognition site; other site 508765001159 dimerization interface [polypeptide binding]; other site 508765001160 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 508765001161 DNA binding site [nucleotide binding] 508765001162 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 508765001163 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 508765001164 dimerization interface [polypeptide binding]; other site 508765001165 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 508765001166 dimer interface [polypeptide binding]; other site 508765001167 phosphorylation site [posttranslational modification] 508765001168 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 508765001169 ATP binding site [chemical binding]; other site 508765001170 Mg2+ binding site [ion binding]; other site 508765001171 G-X-G motif; other site 508765001172 Protein of unknown function (DUF3919); Region: DUF3919; pfam13057 508765001173 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; cl17199 508765001174 Bacterial extracellular solute-binding protein; Region: SBP_bac_8; pfam13416 508765001175 Chaperonin 10 Kd subunit (cpn10 or GroES); Cpn10 cooperates with chaperonin 60 (cpn60 or GroEL), an ATPase, to assist the folding and assembly of proteins and is found in eubacterial cytosol, as well as in the matrix of mitochondria and chloroplasts. It...; Region: cpn10; cd00320 508765001176 oligomerisation interface [polypeptide binding]; other site 508765001177 mobile loop; other site 508765001178 roof hairpin; other site 508765001179 chaperonin GroEL; Reviewed; Region: groEL; PRK12849 508765001180 GroEL_like type I chaperonin. Chaperonins are involved in productive folding of proteins. They share a common general morphology, a double toroid of 2 stacked rings, each composed of 7-9 subunits. The symmetry of type I is seven-fold and they are found...; Region: GroEL; cd03344 508765001181 ring oligomerisation interface [polypeptide binding]; other site 508765001182 ATP/Mg binding site [chemical binding]; other site 508765001183 stacking interactions; other site 508765001184 hinge regions; other site 508765001185 inosine 5'-monophosphate dehydrogenase; Reviewed; Region: PRK05567 508765001186 TIM barrel proteins share a structurally conserved phosphate binding motif and in general share an eight beta/alpha closed barrel structure. Specific for this family is the conserved phosphate binding site at the edges of strands 7 and 8. The phosphate...; Region: TIM_phosphate_binding; cl17186 508765001187 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains in the inosine 5' monophosphate dehydrogenase (IMPDH) protein. IMPDH is an essential enzyme that catalyzes the first step unique to GTP synthesis, playing a...; Region: CBS_pair_IMPDH; cd04601 508765001188 IMPDH: The catalytic domain of the inosine monophosphate dehydrogenase. IMPDH catalyzes the NAD-dependent oxidation of inosine 5'-monophosphate (IMP) to xanthosine 5' monophosphate (XMP). It is a rate-limiting step in the de novo synthesis of...; Region: IMPDH; cd00381 508765001189 active site 508765001190 GMP synthase; Reviewed; Region: guaA; PRK00074 508765001191 Type 1 glutamine amidotransferase (GATase1) domain found in GMP synthetase; Region: GATase1_GMP_Synthase; cd01742 508765001192 AMP/PPi binding site [chemical binding]; other site 508765001193 candidate oxyanion hole; other site 508765001194 catalytic triad [active] 508765001195 potential glutamine specificity residues [chemical binding]; other site 508765001196 The C-terminal domain of GMP synthetase. It contains two subdomains; the ATP pyrophosphatase domain which closes to the N-termial and the dimerization domain at C-terminal end. The ATP-PPase is a twisted, five-stranded parallel beta-sheet sandwiched...; Region: GMP_synthase_C; cd01997 508765001197 ATP Binding subdomain [chemical binding]; other site 508765001198 Ligand Binding sites [chemical binding]; other site 508765001199 Dimerization subdomain; other site 508765001200 Beta-lactamase class D [Defense mechanisms]; Region: COG2602 508765001201 Predicted xylanase/chitin deacetylase [Carbohydrate transport and metabolism]; Region: CDA1; COG0726 508765001202 Putative catalytic NodB homology domain of PgaB, IcaB, and similar proteins which consist of a deformed (beta/alpha)8 barrel fold with 5- or 6-strands; Region: CE4_NodB_like_5s_6s; cd10918 508765001203 putative active site [active] 508765001204 putative metal binding site [ion binding]; other site 508765001205 Essential protein Yae1, N terminal; Region: Yae1_N; pfam09811 508765001206 Essential protein Yae1, N terminal; Region: Yae1_N; pfam09811 508765001207 Essential protein Yae1, N terminal; Region: Yae1_N; pfam09811 508765001208 Transcriptional antiterminator [Transcription]; Region: BglG; COG3711 508765001209 PRD domain; Region: PRD; pfam00874 508765001210 PTS_IIB_bgl_like: the PTS (phosphotransferase system) IIB domain of a family of sensory systems composed of a membrane-bound sugar-sensor (similar to BglF) and a transcription antiterminator (similar to BglG) which regulate expression of genes involved...; Region: PTS_IIB_bgl_like; cd05568 508765001211 active site 508765001212 P-loop; other site 508765001213 phosphorylation site [posttranslational modification] 508765001214 PTS_IIA, PTS system, fructose/mannitol specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_fru; cd00211 508765001215 active site 508765001216 phosphorylation site [posttranslational modification] 508765001217 Glucitol operon activator protein (GutM); Region: GutM; pfam06923 508765001218 PTS system enzyme II sorbitol-specific factor; Region: EII-GUT; pfam03608 508765001219 PTS system glucitol/sorbitol-specific IIA component; Region: PTSIIA_gutA; pfam03829 508765001220 sorbitol-6-phosphate 2-dehydrogenase; Provisional; Region: PRK06171 508765001221 classical (c) SDRs; Region: SDR_c; cd05233 508765001222 NAD(P) binding site [chemical binding]; other site 508765001223 active site 508765001224 Transaldolase-like fructose-6-phosphate aldolases (FSA) found in bacteria and archaea; Region: Transaldolase_FSA; cd00956 508765001225 active site 508765001226 intersubunit interactions; other site 508765001227 catalytic residue [active] 508765001228 glucose-6-phosphate isomerase; Provisional; Region: pgi; PRK14097 508765001229 Phosphoglucose isomerase (PGI) contains two SIS (Sugar ISomerase) domains. This classification is based on the alignment of the first SIS domain. PGI is a multifunctional enzyme which as an intracellular dimer catalyzes the reversible isomerization of...; Region: SIS_PGI_1; cd05015 508765001230 active site 508765001231 dimer interface [polypeptide binding]; other site 508765001232 Phosphoglucose isomerase (PGI) contains two SIS (Sugar ISomerase) domains. This classification is based on the alignment of the second SIS domain. PGI is a multifunctional enzyme which as an intracellular dimer catalyzes the reversible isomerization of...; Region: SIS_PGI_2; cd05016 508765001233 dimer interface [polypeptide binding]; other site 508765001234 active site 508765001235 hypothetical protein; Validated; Region: PRK00124 508765001236 triple tyrosine motif-containing protein; Provisional; Region: PRK14081 508765001237 Y_Y_Y domain; Region: Y_Y_Y; pfam07495 508765001238 Y_Y_Y domain; Region: Y_Y_Y; pfam07495 508765001239 Y_Y_Y domain; Region: Y_Y_Y; pfam07495 508765001240 Soluble lytic murein transglycosylase and related regulatory proteins (some contain LysM/invasin domains) [Cell envelope biogenesis, outer membrane]; Region: MltE; COG0741 508765001241 Lytic Transglycosylase (LT) and Goose Egg White Lysozyme (GEWL) domain. Members include the soluble and insoluble membrane-bound LTs in bacteria, the LTs in bacteriophage lambda, as well as, the eukaryotic "goose-type" lysozymes (GEWL). LTs...; Region: LT_GEWL; cd00254 508765001242 N-acetyl-D-glucosamine binding site [chemical binding]; other site 508765001243 catalytic residue [active] 508765001244 16S rRNA uridine-516 pseudouridylate synthase and related pseudouridylate synthases [Translation, ribosomal structure and biogenesis]; Region: RsuA; COG1187 508765001245 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 508765001246 RNA binding surface [nucleotide binding]; other site 508765001247 Pseudouridine synthase, Escherichia coli RsuA like; Region: PseudoU_synth_RsuA; cd02553 508765001248 active site 508765001249 uracil binding [chemical binding]; other site 508765001250 ATP-dependent DNA helicase PcrA; Region: pcrA; TIGR01073 508765001251 Part of AAA domain; Region: AAA_19; pfam13245 508765001252 Family description; Region: UvrD_C_2; pfam13538 508765001253 NAD-dependent DNA ligase LigA; Validated; Region: ligA; PRK07956 508765001254 NAD+ dependent DNA ligase adenylation domain. DNA ligases catalyze the crucial step of joining the breaks in duplex DNA during DNA replication, repair and recombination, utilizing either ATP or NAD(+) as a cofactor, but using the same basic reaction...; Region: LIGANc; cd00114 508765001255 nucleotide binding pocket [chemical binding]; other site 508765001256 K-X-D-G motif; other site 508765001257 catalytic site [active] 508765001258 NAD-dependent DNA ligase OB-fold domain; Region: DNA_ligase_OB; pfam03120 508765001259 NAD-dependent DNA ligase C4 zinc finger domain; Region: DNA_ligase_ZBD; pfam03119 508765001260 Breast Cancer Suppressor Protein (BRCA1), carboxy-terminal domain. The BRCT domain is found within many DNA damage repair and cell cycle checkpoint proteins. The unique diversity of this domain superfamily allows BRCT modules to interact forming homo...; Region: BRCT; cd00027 508765001261 Dimer interface [polypeptide binding]; other site 508765001262 BRCT sequence motif; other site 508765001263 aspartyl/glutamyl-tRNA amidotransferase subunit C; Reviewed; Region: gatC; PRK00034 508765001264 Asp-tRNAAsn/Glu-tRNAGln amidotransferase A subunit and related amidases [Translation, ribosomal structure and biogenesis]; Region: GatA; COG0154 508765001265 aspartyl/glutamyl-tRNA amidotransferase subunit A; Reviewed; Region: gatA; PRK00012 508765001266 aspartyl/glutamyl-tRNA amidotransferase subunit B; Validated; Region: gatB; PRK05477 508765001267 GatB/GatE catalytic domain; Region: GatB_N; pfam02934 508765001268 GatB domain; Region: GatB_Yqey; smart00845 508765001269 ABC-type dipeptide transport system, periplasmic component [Amino acid transport and metabolism]; Region: DdpA; COG0747 508765001270 The substrate-binding domain of an ABC-type nickel/oligopeptide-like import system contains the type 2 periplasmic binding fold; Region: PBP2_NikA_DppA_OppA_like; cl01709 508765001271 ribonuclease PH; Reviewed; Region: rph; PRK00173 508765001272 Ribonuclease PH; Region: RNase_PH_bact; cd11362 508765001273 hexamer interface [polypeptide binding]; other site 508765001274 active site 508765001275 NTPase/HAM1. This family consists of the HAM1 protein and pyrophosphate-releasing xanthosine/ inosine triphosphatase. HAM1 protects the cell against mutagenesis by the base analog 6-N-hydroxylaminopurine (HAP) in E. Coli and S. cerevisiae. A...; Region: HAM1; cd00515 508765001276 active site 508765001277 dimerization interface [polypeptide binding]; other site 508765001278 Escherichia coli YfcE and related proteins, metallophosphatase domain; Region: MPP_YfcE; cd00841 508765001279 Calcineurin-like phosphoesterase; Region: Metallophos; pfam00149 508765001280 active site 508765001281 metal binding site [ion binding]; metal-binding site 508765001282 homotetramer interface [polypeptide binding]; other site 508765001283 Predicted xylanase/chitin deacetylase [Carbohydrate transport and metabolism]; Region: CDA1; COG0726 508765001284 Catalytic NodB homology domain of Streptococcus mutans polysaccharide deacetylase PgdA, Bacillus subtilis YheN, and similar proteins; Region: CE4_SmPgdA_like; cd10944 508765001285 NodB motif; other site 508765001286 active site 508765001287 catalytic site [active] 508765001288 Zn binding site [ion binding]; other site 508765001289 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 508765001290 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 508765001291 active site 508765001292 phosphorylation site [posttranslational modification] 508765001293 intermolecular recognition site; other site 508765001294 dimerization interface [polypeptide binding]; other site 508765001295 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 508765001296 DNA binding site [nucleotide binding] 508765001297 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 508765001298 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 508765001299 dimerization interface [polypeptide binding]; other site 508765001300 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 508765001301 dimer interface [polypeptide binding]; other site 508765001302 phosphorylation site [posttranslational modification] 508765001303 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 508765001304 ATP binding site [chemical binding]; other site 508765001305 Mg2+ binding site [ion binding]; other site 508765001306 G-X-G motif; other site 508765001307 Predicted Zn-dependent proteases and their inactivated homologs [General function prediction only]; Region: TldD; COG0312 508765001308 Predicted Zn-dependent proteases and their inactivated homologs [General function prediction only]; Region: TldD; COG0312 508765001309 Phosphoglycerol transferase and related proteins, alkaline phosphatase superfamily [Cell envelope biogenesis, outer membrane]; Region: MdoB; COG1368 508765001310 Sulfatase; Region: Sulfatase; cl17466 508765001311 SirA, YedF, and YeeD. Two-layered alpha/beta sandwich domain. SirA (also known as UvrY, and YhhP) belongs to a family of bacterial two-component response regulators that controls secondary metabolism and virulence. The other member of this...; Region: SirA_YedF_YeeD; cl00436 508765001312 selenium metabolism protein YedF; Region: selenium_YedF; TIGR03527 508765001313 CPxP motif; other site 508765001314 DsrE/DsrF-like family; Region: DrsE; cl00672 508765001315 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox_2; pfam07992 508765001316 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500 508765001317 SGNH_hydrolase, or GDSL_hydrolase, is a diverse family of lipases and esterases. The tertiary fold of the enzyme is substantially different from that of the alpha/beta hydrolase family and unique among all known hydrolases; its active site closely...; Region: SGNH_hydrolase; cl01053 508765001318 active site 508765001319 catalytic triad [active] 508765001320 oxyanion hole [active] 508765001321 Endodeoxyribonuclease RusA; Region: RusA; pfam05866 508765001322 UGMP family protein; Validated; Region: PRK09604 508765001323 tRNA threonylcarbamoyl adenosine modification protein YeaZ; Region: T6A_YeaZ; TIGR03725 508765001324 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 508765001325 Trypsin-like peptidase domain; Region: Trypsin_2; pfam13365 508765001326 active site 508765001327 PDZ domain of tryspin-like serine proteases, such as DegP/HtrA, which are oligomeric proteins involved in heat-shock response, chaperone function, and apoptosis. May be responsible for substrate recognition and/or binding, as most PDZ domains bind...; Region: PDZ_serine_protease; cd00987 508765001328 protein binding site [polypeptide binding]; other site 508765001329 Carboxypeptidase regulatory-like domain; Region: CarboxypepD_reg; pfam13620 508765001330 ethanolamine utilization protein EutH; Provisional; Region: PRK15086 508765001331 ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653 508765001332 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 508765001333 This family is most closely related to the GT1 family of glycosyltransferases. mtfB (mannosyltransferase B) in E. coli has been shown to direct the growth of the O9-specific polysaccharide chain. It transfers two mannoses into the position 3 of the...; Region: GT1_mtfB_like; cd03809 508765001334 spore coat protein, CotS family; Region: spore_CotS; TIGR02906 508765001335 spore coat protein YutH; Region: spore_yutH; TIGR02905 508765001336 spore coat protein, CotS family; Region: spore_CotS; TIGR02906 508765001337 spore coat protein, CotS family; Region: spore_CotS; TIGR02906 508765001338 Aminoglycoside 3'-phosphotransferase (APH) and Choline Kinase (ChoK) family. The APH/ChoK family is part of a larger superfamily that includes the catalytic domains of other kinases, such as the typical serine/threonine/tyrosine protein kinases (PKs)...; Region: APH_ChoK_like; cd05120 508765001339 substrate binding site [chemical binding]; other site 508765001340 This family is most closely related to the GT1 family of glycosyltransferases. mtfB (mannosyltransferase B) in E. coli has been shown to direct the growth of the O9-specific polysaccharide chain. It transfers two mannoses into the position 3 of the...; Region: GT1_mtfB_like; cd03809 508765001341 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 508765001342 Aminoglycoside 3'-phosphotransferase (APH) and Choline Kinase (ChoK) family. The APH/ChoK family is part of a larger superfamily that includes the catalytic domains of other kinases, such as the typical serine/threonine/tyrosine protein kinases (PKs)...; Region: APH_ChoK_like; cl17270 508765001343 spore coat protein, CotS family; Region: spore_CotS; TIGR02906 508765001344 active site 508765001345 ATP binding site [chemical binding]; other site 508765001346 Aminoglycoside 3'-phosphotransferase (APH) and Choline Kinase (ChoK) family. The APH/ChoK family is part of a larger superfamily that includes the catalytic domains of other kinases, such as the typical serine/threonine/tyrosine protein kinases (PKs)...; Region: APH_ChoK_like; cd05120 508765001347 substrate binding site [chemical binding]; other site 508765001348 YabG peptidase U57; Region: Peptidase_U57; pfam05582 508765001349 Protein of unknown function (DUF1021); Region: DUF1021; pfam06257 508765001350 Domain of unknown function (DUF3794); Region: DUF3794; pfam12673 508765001351 Domain of unknown function (DUF3794); Region: DUF3794; pfam12673 508765001352 Domain of unknown function (DUF3794); Region: DUF3794; pfam12673 508765001353 FOG: LysM repeat [Cell envelope biogenesis, outer membrane]; Region: LytE; COG1388 508765001354 Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118 508765001355 Type 1 glutamine amidotransferase (GATase1)-like domain found in cyanophycinase; Region: GAT1_cyanophycinase; cd03145 508765001356 proposed catalytic triad [active] 508765001357 active site nucleophile [active] 508765001358 cyanophycin synthetase; Provisional; Region: PRK14016 508765001359 ATP-grasp domain; Region: ATP-grasp_4; cl17255 508765001360 Mur ligase middle domain; Region: Mur_ligase_M; pfam08245 508765001361 Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875 508765001362 4-diphosphocytidyl-2-C-methyl-D-erythritol kinase; Provisional; Region: ipk; PRK00128 508765001363 GHMP kinases N terminal domain; Region: GHMP_kinases_N; pfam00288 508765001364 GHMP kinases C terminal; Region: GHMP_kinases_C; pfam08544 508765001365 Stage II sporulation protein R (spore_II_R); Region: Spore_II_R; pfam09551 508765001366 Predicted tRNA(5-methylaminomethyl-2-thiouridylate) methyltransferase, contains the PP-loop ATPase domain [Translation, ribosomal structure and biogenesis]; Region: TrmU; COG0482 508765001367 ThiI is required for thiazole synthesis in the thiamine biosynthesis pathway. It belongs to the Adenosine Nucleotide Hydrolysis suoerfamily and predicted to bind to Adenosine nucleotide; Region: ThiI; cd01712 508765001368 Ligand Binding Site [chemical binding]; other site 508765001369 Domain of unknown function (DUF814); Region: DUF814; pfam05670 508765001370 Domain of unknown function (DUF1934); Region: DUF1934; pfam09148 508765001371 CTP synthetase; Validated; Region: pyrG; PRK05380 508765001372 CTP synthetase (CTPs) is a two-domain protein, which consists of an N-terminal synthetase domain and C-terminal glutaminase domain. The enzymes hydrolyze the amide bond of glutamine to ammonia and glutamate at the glutaminase domains and transfer nascent...; Region: CTGs; cd03113 508765001373 Catalytic site [active] 508765001374 active site 508765001375 UTP binding site [chemical binding]; other site 508765001376 Type 1 glutamine amidotransferase (GATase1) domain found in Cytidine Triphosphate Synthetase; Region: GATase1_CTP_Synthase; cd01746 508765001377 active site 508765001378 putative oxyanion hole; other site 508765001379 catalytic triad [active] 508765001380 Rho termination factor, N-terminal domain; Region: Rho_N; pfam07498 508765001381 transcription termination factor Rho; Provisional; Region: PRK12608 508765001382 Rho_CSD: Rho protein cold-shock domain (CSD). Rho protein is a transcription termination factor in most bacteria. In bacteria, there are two distinct mechanisms for mRNA transcription termination. In intrinsic termination, RNA polymerase and nascent mRNA...; Region: Rho_CSD; cd04459 508765001383 RNA binding site [nucleotide binding]; other site 508765001384 Transcription termination factor rho is a bacterial ATP-dependent RNA/DNA helicase. It is a homohexamer. Each monomer consists of an N-terminal domain of the OB fold, which is responsible for binding to cysteine rich nucleotides. This alignment is of the...; Region: rho_factor; cd01128 508765001385 multimer interface [polypeptide binding]; other site 508765001386 Walker A motif; other site 508765001387 ATP binding site [chemical binding]; other site 508765001388 Walker B motif; other site 508765001389 UDP-N-acetylglucosamine:LPS N-acetylglucosamine transferase [Cell envelope biogenesis, outer membrane]; Region: MurG; COG0707 508765001390 Monogalactosyldiacylglycerol (MGDG) synthase; Region: MGDG_synth; pfam06925 508765001391 Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013 508765001392 50S ribosomal protein L31; Reviewed; Region: rpmE; PRK00019 508765001393 thymidine kinase; Provisional; Region: PRK04296 508765001394 Protein of unknown function (DUF1385); Region: DUF1385; cl01595 508765001395 N5-glutamine S-adenosyl-L-methionine-dependent methyltransferase; Provisional; Region: PRK09328 508765001396 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 508765001397 S-adenosylmethionine binding site [chemical binding]; other site 508765001398 peptide chain release factor 1; Validated; Region: prfA; PRK00591 508765001399 This domain is found in peptide chain release factors; Region: PCRF; smart00937 508765001400 RF-1 domain; Region: RF-1; pfam00472 508765001401 Putative translation factor (SUA5) [Translation, ribosomal structure and biogenesis]; Region: SUA5; COG0009 508765001402 Putative GTP-binding controlling metal-binding; Region: SUA5; pfam03481 508765001403 ribose-5-phosphate isomerase B; Provisional; Region: PRK05571 508765001404 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 508765001405 active site 508765001406 Deoxycytidylate deaminase [Nucleotide transport and metabolism]; Region: ComEB; COG2131 508765001407 active site 508765001408 Zn binding site [ion binding]; other site 508765001409 UDP-N-acetylglucosamine 2-epimerase [Cell envelope biogenesis, outer membrane]; Region: WecB; COG0381 508765001410 Bacterial members of the UDP-N-Acetylglucosamine (GlcNAc) 2-Epimerase family are known to catalyze the reversible interconversion of UDP-GlcNAc and UDP-N-acetylmannosamine (UDP-ManNAc). The enzyme serves to produce an activated form of ManNAc residues; Region: GT1_UDP-GlcNAc_2-Epimerase; cd03786 508765001411 active site 508765001412 homodimer interface [polypeptide binding]; other site 508765001413 putative acyltransferase; Provisional; Region: PRK05790 508765001414 Thiolase are ubiquitous enzymes that catalyze the reversible thiolytic cleavage of 3-ketoacyl-CoA into acyl-CoA and acetyl-CoA, a 2-step reaction involving a covalent intermediate formed with a catalytic cysteine. They are found in prokaryotes and...; Region: thiolase; cd00751 508765001415 dimer interface [polypeptide binding]; other site 508765001416 active site 508765001417 F0F1-type ATP synthase, subunit a [Energy production and conversion]; Region: AtpB; COG0356 508765001418 F0F1 ATP synthase subunit A; Validated; Region: PRK05815 508765001419 F0F1 ATP synthase subunit C; Provisional; Region: PRK13469 508765001420 F0F1 ATP synthase subunit B; Provisional; Region: PRK13461 508765001421 F0F1 ATP synthase subunit B; Validated; Region: PRK05759 508765001422 F0F1 ATP synthase subunit delta; Validated; Region: PRK05758 508765001423 ATP synthase delta (OSCP) subunit; Region: OSCP; pfam00213 508765001424 F0F1 ATP synthase subunit alpha; Validated; Region: PRK09281 508765001425 ATP synthase alpha/beta family, beta-barrel domain; Region: ATP-synt_ab_N; pfam02874 508765001426 F1 ATP synthase alpha, central domain. The F-ATPase is found in bacterial plasma membranes, mitochondrial inner membranes and in chloroplast thylakoid membranes. It has also been found in the archaea Methanosarcina barkeri. It uses a proton gradient to...; Region: F1_ATPase_alpha; cd01132 508765001427 beta subunit interaction interface [polypeptide binding]; other site 508765001428 Walker A motif; other site 508765001429 ATP binding site [chemical binding]; other site 508765001430 Walker B motif; other site 508765001431 ATP synthase alpha/beta chain, C terminal domain; Region: ATP-synt_ab_C; pfam00306 508765001432 mitochondrial ATP synthase gamma subunit; Region: F1-ATPase_gamma; cd12151 508765001433 core domain interface [polypeptide binding]; other site 508765001434 delta subunit interface [polypeptide binding]; other site 508765001435 epsilon subunit interface [polypeptide binding]; other site 508765001436 F0F1 ATP synthase subunit beta; Validated; Region: PRK09280 508765001437 ATP synthase alpha/beta family, beta-barrel domain; Region: ATP-synt_ab_N; pfam02874 508765001438 F1 ATP synthase beta subunit, nucleotide-binding domain. The F-ATPase is found in bacterial plasma membranes, mitochondrial inner membranes and in chloroplast thylakoid membranes. It has also been found in the archaea Methanosarcina barkeri. It uses a...; Region: F1-ATPase_beta; cd01133 508765001439 alpha subunit interaction interface [polypeptide binding]; other site 508765001440 Walker A motif; other site 508765001441 ATP binding site [chemical binding]; other site 508765001442 Walker B motif; other site 508765001443 inhibitor binding site; inhibition site 508765001444 ATP synthase alpha/beta chain, C terminal domain; Region: ATP-synt_ab_C; pfam00306 508765001445 F0F1 ATP synthase subunit epsilon; Provisional; Region: atpC; PRK13450 508765001446 mitochondrial ATP synthase delta subunit; Region: F1-ATPase_delta; cd12152 508765001447 gamma subunit interface [polypeptide binding]; other site 508765001448 epsilon subunit interface [polypeptide binding]; other site 508765001449 LBP interface [polypeptide binding]; other site 508765001450 UDP-N-acetylglucosamine 1-carboxyvinyltransferase; Region: murA; TIGR01072 508765001451 UDP-N-acetylglucosamine enolpyruvyl transferase catalyzes enolpyruvyl transfer as part of the first step in the biosynthesis of peptidoglycan, a component of the bacterial cell wall. The reaction is phosphoenolpyruvate + UDP-N-acetyl-D-glucosamine =...; Region: UdpNAET; cd01555 508765001452 hinge; other site 508765001453 active site 508765001454 SpoIID/LytB domain; Region: SpoIID_LytB; TIGR02669 508765001455 Stage II sporulation protein; Region: SpoIID; pfam08486 508765001456 Membrane proteins related to metalloendopeptidases [Cell envelope biogenesis, outer membrane]; Region: NlpD; COG0739 508765001457 Peptidase family M23; Region: Peptidase_M23; pfam01551 508765001458 Stage III sporulation protein D; Region: SpoIIID; pfam12116 508765001459 rod shape-determining protein Mbl; Provisional; Region: PRK13928 508765001460 MreB and similar proteins; Region: MreB_like; cd10225 508765001461 nucleotide binding site [chemical binding]; other site 508765001462 Mg binding site [ion binding]; other site 508765001463 putative protofilament interaction site [polypeptide binding]; other site 508765001464 RodZ interaction site [polypeptide binding]; other site 508765001465 Protein of unknown function (DUF1256); Region: DUF1256; pfam06866 508765001466 S-adenosylmethionine synthetase; Validated; Region: PRK05250 508765001467 S-adenosylmethionine synthetase, N-terminal domain; Region: S-AdoMet_synt_N; pfam00438 508765001468 S-adenosylmethionine synthetase, central domain; Region: S-AdoMet_synt_M; pfam02772 508765001469 S-adenosylmethionine synthetase, C-terminal domain; Region: S-AdoMet_synt_C; pfam02773 508765001470 helicase, putative, RecD/TraA family; Region: recD_rel; TIGR01448 508765001471 H3TH domains of structure-specific 5' nucleases (or flap endonuclease-1-like) involved in DNA replication, repair, and recombination; Region: H3TH_StructSpec-5'-nucleases; cl14815 508765001472 DNA binding site [nucleotide binding] 508765001473 AAA domain; Region: AAA_30; pfam13604 508765001474 Family description; Region: UvrD_C_2; pfam13538 508765001475 comF family protein; Region: comF; TIGR00201 508765001476 RaiA ("ribosome-associated inhibitor A", also known as Protein Y (PY), YfiA, and SpotY, is a stress-response protein that binds the ribosomal subunit interface and arrests translation by interfering with aminoacyl-tRNA binding to the ribosomal...; Region: RaiA; cd00552 508765001477 30S subunit binding site; other site 508765001478 preprotein translocase subunit SecA; Reviewed; Region: PRK12904 508765001479 DEAD/DEAH box helicase; Region: DEAD; pfam00270 508765001480 ATP binding site [chemical binding]; other site 508765001481 putative Mg++ binding site [ion binding]; other site 508765001482 SecA preprotein cross-linking domain; Region: SecA_PP_bind; smart00958 508765001483 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cl17351 508765001484 nucleotide binding region [chemical binding]; other site 508765001485 ATP-binding site [chemical binding]; other site 508765001486 SEC-C motif; Region: SEC-C; pfam02810 508765001487 peptide chain release factor 2; Provisional; Region: PRK05589 508765001488 This domain is found in peptide chain release factors; Region: PCRF; smart00937 508765001489 RF-1 domain; Region: RF-1; pfam00472 508765001490 Zinc peptidases M18, M20, M28, and M42; Region: Zinc_peptidase_like; cl14876 508765001491 M28 Zn-Peptidases containing a PA domain insert; Region: M28_like_PA; cd03877 508765001492 Peptidase family M28; Region: Peptidase_M28; pfam04389 508765001493 metal binding site [ion binding]; metal-binding site 508765001494 Transcriptional accessory protein [Transcription]; Region: Tex; COG2183 508765001495 Tex-like protein N-terminal domain; Region: Tex_N; pfam09371 508765001496 Likely ribonuclease with RNase H fold; Region: YqgFc; smart00732 508765001497 S1_Tex: The C-terminal S1 domain of a transcription accessory factor called Tex, which has been characterized in Bordetella pertussis and Pseudomonas aeruginosa. The tex gene is essential in Bortella pertusis and is named for its role in toxin expression; Region: S1_Tex; cd05685 508765001498 RNA binding site [nucleotide binding]; other site 508765001499 Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673 508765001500 Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408 508765001501 Permeases of the drug/metabolite transporter (DMT) superfamily [Carbohydrate transport and metabolism / Amino acid transport and metabolism / General function prediction only]; Region: RhaT; COG0697 508765001502 EamA-like transporter family; Region: EamA; pfam00892 508765001503 EamA-like transporter family; Region: EamA; pfam00892 508765001504 Predicted membrane protein [Function unknown]; Region: COG3601 508765001505 Protein of unknown function (DUF3816); Region: DUF3816; pfam12822 508765001506 ribosomal-protein-alanine acetyltransferase; Region: rimI; TIGR01575 508765001507 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 508765001508 Coenzyme A binding pocket [chemical binding]; other site 508765001509 tRNA threonylcarbamoyl adenosine modification protein YeaZ; Region: T6A_YeaZ; TIGR03725 508765001510 Glycoprotease family; Region: Peptidase_M22; pfam00814 508765001511 Predicted ATPase or kinase [General function prediction only]; Region: COG0802 508765001512 Helical backbone metal receptor (TroA-like domain). These proteins have been shown to function in the ABC transport of ferric siderophores and metal ions such as Mn2+, Fe3+, Cu2+ and/or Zn2+. Their ligand binding site is formed in the interface between...; Region: TroA-like; cl00262 508765001513 Periplasmic solute binding protein family; Region: SBP_bac_9; pfam01297 508765001514 intersubunit interface [polypeptide binding]; other site 508765001515 Predicted sensor domain [Signal transduction mechanisms / Transcription]; Region: PocR; COG4936 508765001516 Sensory domain found in PocR; Region: PocR; pfam10114 508765001517 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 508765001518 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 508765001519 Glycerol dehydrogenase and related enzymes [Energy production and conversion]; Region: GldA; COG0371 508765001520 Glycerol dehydrogenases (GlyDH) catalyzes oxidation of glycerol to dihydroxyacetone in glycerol dissmilation; Region: GlyDH; cd08170 508765001521 dimer interface [polypeptide binding]; other site 508765001522 active site 508765001523 metal binding site [ion binding]; metal-binding site 508765001524 dihydroxyacetone kinase; Provisional; Region: PRK14479 508765001525 dihydroxyacetone kinase subunit DhaK; Provisional; Region: PRK14481 508765001526 DAK2 domain; Region: Dak2; pfam02734 508765001527 The Ntn hydrolases (N-terminal nucleophile) are a diverse superfamily of of enzymes that are activated autocatalytically via an N-terminally lcated nucleophilic amino acid. N-terminal nucleophile (NTN-) hydrolase superfamily, which contains a...; Region: Ntn_hydrolase; cl00467 508765001528 Peptidase S8 family domain in CspA-like proteins; Region: Peptidases_S8_CspA-like; cd07478 508765001529 active site 508765001530 catalytic triad [active] 508765001531 Peptidase S8 family domain in CspA-like proteins; Region: Peptidases_S8_CspA-like; cd07478 508765001532 active site 508765001533 catalytic triad [active] 508765001534 Dioxygenases related to 2-nitropropane dioxygenase [General function prediction only]; Region: COG2070 508765001535 2-Nitropropane dioxygenase (NPD), one of the nitroalkane oxidizing enzyme families, catalyzes oxidative denitrification of nitroalkanes to their corresponding carbonyl compounds and nitrites. NDP is a member of the NAD(P)H-dependent flavin oxidoreductase...; Region: NPD_like; cd04730 508765001536 FMN binding site [chemical binding]; other site 508765001537 substrate binding site [chemical binding]; other site 508765001538 putative catalytic residue [active] 508765001539 Small, acid-soluble spore proteins, alpha/beta type; Region: SASP; pfam00269 508765001540 DNA-directed RNA polymerase specialized sigma subunit, sigma24 homolog [Transcription]; Region: RpoE; COG1595 508765001541 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 508765001542 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 508765001543 DNA binding residues [nucleotide binding] 508765001544 Domain of unknown function (DUF4179); Region: DUF4179; pfam13786 508765001545 Mre11 nuclease, N-terminal metallophosphatase domain; Region: MPP_Mre11_N; cd00840 508765001546 Calcineurin-like phosphoesterase; Region: Metallophos; pfam00149 508765001547 active site 508765001548 metal binding site [ion binding]; metal-binding site 508765001549 DNA binding site [nucleotide binding] 508765001550 Putative exonuclease SbcCD, C subunit; Region: SbcCD_C; pfam13558 508765001551 Metal binding protein AcdA. These proteins have been shown to function in the ABC uptake of Zn2+ and Mn2+ and in competence for genetic transformation and adhesion. The AcdA proteins belong to the TroA superfamily of helical backbone metal receptor...; Region: AdcA; cd01017 508765001552 Periplasmic solute binding protein family; Region: SBP_bac_9; pfam01297 508765001553 metal binding site [ion binding]; metal-binding site 508765001554 Mismatch repair ATPase (MutS family) [DNA replication, recombination, and repair]; Region: MutS; COG0249 508765001555 ATP-binding cassette domain of MutS-like homolog; Region: ABC_MutS-like; cd03283 508765001556 Walker A/P-loop; other site 508765001557 ATP binding site [chemical binding]; other site 508765001558 Q-loop/lid; other site 508765001559 ABC transporter signature motif; other site 508765001560 Walker B; other site 508765001561 D-loop; other site 508765001562 H-loop/switch region; other site 508765001563 DEDDh 3'-5' exonuclease domain of Caenorhabditis elegans ERI-1, human 3' exonuclease, and similar proteins; Region: ERI-1_3'hExo_like; cd06133 508765001564 active site 508765001565 catalytic site [active] 508765001566 substrate binding site [chemical binding]; other site 508765001567 FOG: CBS domain [General function prediction only]; Region: COG0517 508765001568 The CBS domain, named after human CBS, is a small domain originally identified in cystathionine beta-synthase and is subsequently found in a wide range of different proteins. CBS domains usually occur in tandem repeats. They associate to form a so-called...; Region: CBS_pair_30; cd04643 508765001569 Phage shock protein A (IM30), suppresses sigma54-dependent transcription [Transcription / Signal transduction mechanisms]; Region: PspA; COG1842 508765001570 30S ribosomal protein S1; Reviewed; Region: rpsA; PRK06676 508765001571 S1_RPS1_repeat_ec1_hs1: Ribosomal protein S1 (RPS1) domain. RPS1 is a component of the small ribosomal subunit thought to be involved in the recognition and binding of mRNA's during translation initiation. The bacterial RPS1 domain architecture...; Region: S1_RPS1_repeat_ec1_hs1; cd05687 508765001572 RNA binding site [nucleotide binding]; other site 508765001573 S1_RPS1_repeat_ec2_hs2: Ribosomal protein S1 (RPS1) domain. RPS1 is a component of the small ribosomal subunit thought to be involved in the recognition and binding of mRNA's during translation initiation. The bacterial RPS1 domain architecture...; Region: S1_RPS1_repeat_ec2_hs2; cd04465 508765001574 RNA binding site [nucleotide binding]; other site 508765001575 S1_like: Ribosomal protein S1-like RNA-binding domain. Found in a wide variety of RNA-associated proteins. Originally identified in S1 ribosomal protein. This superfamily also contains the Cold Shock Domain (CSD), which is a homolog of the S1 domain; Region: S1_like; cl09927 508765001576 RNA binding site [nucleotide binding]; other site 508765001577 S1_PNPase: Polynucleotide phosphorylase (PNPase), ), S1-like RNA-binding domain. PNPase is a polyribonucleotide nucleotidyl transferase that degrades mRNA. It is a trimeric multidomain protein. The C-terminus contains the S1 domain which binds ssRNA; Region: S1_PNPase; cd04472 508765001578 RNA binding site [nucleotide binding]; other site 508765001579 domain interface; other site 508765001580 Pyruvate kinase [Carbohydrate transport and metabolism]; Region: PykF; COG0469 508765001581 Pyruvate kinase (PK): Large allosteric enzyme that regulates glycolysis through binding of the substrate, phosphoenolpyruvate, and one or more allosteric effectors. Like other allosteric enzymes, PK has a high substrate affinity R state and a low...; Region: Pyruvate_Kinase; cl17342 508765001582 domain interfaces; other site 508765001583 active site 508765001584 Xaa-His dipeptidase; Region: aa-his-dipept; TIGR01893 508765001585 M20 Peptidase D has specificity for beta-alanyl-L-histidine dipeptide; Region: M20_pepD; cd03890 508765001586 metal binding site [ion binding]; metal-binding site 508765001587 dimer interface [polypeptide binding]; other site 508765001588 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 508765001589 Coenzyme A binding pocket [chemical binding]; other site 508765001590 Sporulation related domain; Region: SPOR; cl10051 508765001591 Maf-like protein; Reviewed; Region: PRK00078 508765001592 Nucleotide binding protein Maf. Maf has been implicated in inhibition of septum formation in eukaryotes, bacteria and archaea, but homologs in B.subtilis and S.cerevisiae are nonessential for cell division. Maf has been predicted to be a nucleotide- or...; Region: Maf; cd00555 508765001593 active site 508765001594 dimer interface [polypeptide binding]; other site 508765001595 hypothetical protein; Reviewed; Region: PRK00024 508765001596 endonuclease III; includes endonuclease III (DNA-(apurinic or apyrimidinic site) lyase), alkylbase DNA glycosidases (Alka-family) and other DNA glycosidases; Region: ENDO3c; cl14786 508765001597 helix-hairpin-helix signature motif; other site 508765001598 Mov34/MPN/PAD-1 family; Region: MPN_DUF2466; cd08071 508765001599 MPN+ (JAMM) motif; other site 508765001600 Zinc-binding site [ion binding]; other site 508765001601 rod shape-determining protein MreB; Provisional; Region: PRK13927 508765001602 MreB and similar proteins; Region: MreB_like; cd10225 508765001603 nucleotide binding site [chemical binding]; other site 508765001604 Mg binding site [ion binding]; other site 508765001605 putative protofilament interaction site [polypeptide binding]; other site 508765001606 RodZ interaction site [polypeptide binding]; other site 508765001607 rod shape-determining protein MreC; Provisional; Region: PRK13922 508765001608 rod shape-determining protein MreC; Region: MreC; pfam04085 508765001609 rod shape-determining protein MreD; Region: shape_MreD; TIGR03426 508765001610 Penicillin-binding Protein dimerisation domain; Region: PBP_dimer; pfam03717 508765001611 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; cl17760 508765001612 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; cl17760 508765001613 septum formation inhibitor; Reviewed; Region: minC; PRK00513 508765001614 Septum formation inhibitor MinC, C-terminal domain; Region: MinC_C; pfam03775 508765001615 septum site-determining protein MinD; Region: minD_bact; TIGR01968 508765001616 Bacterial cell division requires the formation of a septum at mid-cell. The site is determined by the min operon products MinC, MinD and MinE. MinC is a nonspecific inhibitor of the septum protein FtsZ. MinE is the supressor of MinC. MinD plays a pivotal...; Region: MinD; cd02036 508765001617 Switch I; other site 508765001618 Switch II; other site 508765001619 cell division topological specificity factor MinE; Provisional; Region: PRK13987 508765001620 rod shape-determining protein RodA; Region: rodA_shape; TIGR02210 508765001621 Methylglyoxal synthase catalyzes the enolization of dihydroxyacetone phosphate (DHAP) to produce methylglyoxal. The first part of the catalytic mechanism is believed to be similar to TIM (triosephosphate isomerase) in that both enzymes utilize DHAP to...; Region: MGS; cd01422 508765001622 active site 508765001623 dimer interfaces [polypeptide binding]; other site 508765001624 catalytic residues [active] 508765001625 Peptidase family M23; Region: Peptidase_M23; pfam01551 508765001626 SpoIVFB Site-2 protease (S2P), a zinc metalloprotease (MEROPS family M50B), regulates intramembrane proteolysis (RIP), and is involved in the pro-sigmaK pathway of bacterial spore formation. SpoIVFB (sporulation protein, stage IV cell wall formation, F...; Region: S2P-M50_SpoIVFB; cd06161 508765001627 Peptidase family M50; Region: Peptidase_M50; pfam02163 508765001628 active site 508765001629 putative substrate binding region [chemical binding]; other site 508765001630 radical SAM family uncharacterized protein; Region: rSAM_fuse_unch; TIGR03960 508765001631 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 508765001632 FeS/SAM binding site; other site 508765001633 radical SAM-linked protein; Region: sam_1_link_chp; TIGR03936 508765001634 Uncharacterized protein conserved in bacteria (DUF2344); Region: DUF2344; pfam10105 508765001635 ribonuclease, Rne/Rng family; Region: RNaseEG; TIGR00757 508765001636 S1_RNase_E: RNase E and RNase G, S1-like RNA-binding domain. RNase E is an essential endoribonuclease in the processing and degradation of RNA. In addition to its role in mRNA degradation, RNase E has also been implicated in the processing of rRNA, and...; Region: S1_RNase_E; cd04453 508765001637 homodimer interface [polypeptide binding]; other site 508765001638 oligonucleotide binding site [chemical binding]; other site 508765001639 50S ribosomal protein L21/unknown domain fusion protein; Provisional; Region: PRK12278 508765001640 50S ribosomal protein L21; Validated; Region: rplU; PRK05573 508765001641 hypothetical protein; Provisional; Region: PRK14553 508765001642 50S ribosomal protein L27; Validated; Region: rpmA; PRK05435 508765001643 GTPase CgtA; Reviewed; Region: obgE; PRK12297 508765001644 GTP1/OBG; Region: GTP1_OBG; pfam01018 508765001645 Obg GTPase; Region: Obg; cd01898 508765001646 G1 box; other site 508765001647 GTP/Mg2+ binding site [chemical binding]; other site 508765001648 Switch I region; other site 508765001649 G2 box; other site 508765001650 G3 box; other site 508765001651 Switch II region; other site 508765001652 G4 box; other site 508765001653 G5 box; other site 508765001654 Domain of unknown function (DUF1967); Region: DUF1967; pfam09269 508765001655 Predicted RNA-binding protein containing KH domain, possibly ribosomal protein [Translation, ribosomal structure and biogenesis]; Region: COG1534 508765001656 nicotinic acid mononucleotide adenylyltransferase; Provisional; Region: nadD; PRK00071 508765001657 Nicotinamide/nicotinate mononucleotide adenylyltransferase; Region: NMNAT; cd02165 508765001658 active site 508765001659 (T/H)XGH motif; other site 508765001660 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 508765001661 Zn2+ binding site [ion binding]; other site 508765001662 Mg2+ binding site [ion binding]; other site 508765001663 Transcriptional regulator [Transcription]; Region: LytR; COG1316 508765001664 LytR cell envelope-related transcriptional attenuator; Region: LytR_C; pfam13399 508765001665 Pseudouridylate synthases, 23S RNA-specific [Translation, ribosomal structure and biogenesis]; Region: RluA; COG0564 508765001666 Pseudouridine synthase, RsuA/RluD family; Region: PseudoU_synth_RluCD_like; cd02869 508765001667 active site 508765001668 D-alanyl-D-alanine carboxypeptidase; Region: Peptidase_S11; pfam00768 508765001669 Beta-lactamase enzyme family; Region: Beta-lactamase2; cl17872 508765001670 Penicillin-binding protein 5, C-terminal domain; Region: PBP5_C; smart00936 508765001671 SLBB domain; Region: SLBB; pfam10531 508765001672 comEA protein; Region: comE; TIGR01259 508765001673 TRAM domain; Region: TRAM; cl01282 508765001674 SAM-dependent methyltransferases related to tRNA (uracil-5-)-methyltransferase [Translation, ribosomal structure and biogenesis]; Region: TrmA; COG2265 508765001675 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 508765001676 S-adenosylmethionine binding site [chemical binding]; other site 508765001677 tyrosine recombinase XerC; Region: recomb_XerC; TIGR02224 508765001678 phiLC3 phage and phage-related integrases, site-specific recombinases, DNA breaking-rejoining enzymes, C-terminal catalytic domain. This CD includes various bacterial (mainly gram positive) and phage integrases, including those similar to Lactococcus...; Region: INT_phiLC3_C; cd01189 508765001679 Int/Topo IB signature motif; other site 508765001680 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 508765001681 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 508765001682 non-specific DNA binding site [nucleotide binding]; other site 508765001683 salt bridge; other site 508765001684 sequence-specific DNA binding site [nucleotide binding]; other site 508765001685 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 508765001686 non-specific DNA binding site [nucleotide binding]; other site 508765001687 salt bridge; other site 508765001688 sequence-specific DNA binding site [nucleotide binding]; other site 508765001689 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 508765001690 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 508765001691 non-specific DNA binding site [nucleotide binding]; other site 508765001692 salt bridge; other site 508765001693 sequence-specific DNA binding site [nucleotide binding]; other site 508765001694 Helix-turn-helix domain; Region: HTH_17; pfam12728 508765001695 Replication initiation and membrane attachment; Region: DnaB_2; cl12121 508765001696 YvrJ protein family; Region: YvrJ; pfam12841 508765001697 Superfamily of nucleases including Short Patch Repair (Vsr) Endonucleases, archaeal Holliday junction resolvases, MutH methy-directed DNA mismatch-repair endonucleases, and catalytic domains of many restriction endonucleases, such as EcoRI, BamHI, and...; Region: Restriction_endonuclease_like; cl00277 508765001698 putative active site [active] 508765001699 Superfamily of nucleases including Short Patch Repair (Vsr) Endonucleases, archaeal Holliday junction resolvases, MutH methy-directed DNA mismatch-repair endonucleases, and catalytic domains of many restriction endonucleases, such as EcoRI, BamHI, and...; Region: Restriction_endonuclease_like; cl00277 508765001700 putative active site [active] 508765001701 Cytosine-C5 specific DNA methylases; Methyl transfer reactions play an important role in many aspects of biology. Cytosine-specific DNA methylases are found both in prokaryotes and eukaryotes. DNA methylation, or the covalent addition of a methyl group...; Region: Cyt_C5_DNA_methylase; cd00315 508765001702 DNA-methyltransferase (dcm); Region: dcm; TIGR00675 508765001703 cofactor binding site; other site 508765001704 DNA binding site [nucleotide binding] 508765001705 substrate interaction site [chemical binding]; other site 508765001706 Cytosine-C5 specific DNA methylases; Methyl transfer reactions play an important role in many aspects of biology. Cytosine-specific DNA methylases are found both in prokaryotes and eukaryotes. DNA methylation, or the covalent addition of a methyl group...; Region: Cyt_C5_DNA_methylase; cd00315 508765001707 Domain of unknown function (DUF3883); Region: DUF3883; pfam13020 508765001708 RNA polymerase sigma factor, sigma-70 family; Region: sigma70-ECF; TIGR02937 508765001709 N-acetylmuramoyl-L-alanine amidase [Cell envelope biogenesis, outer membrane]; Region: AmiC; COG0860 508765001710 N-acetylmuramoyl-L-alanine amidase or MurNAc-LAA (also known as peptidoglycan aminohydrolase, NAMLA amidase, NAMLAA, Amidase 3, and peptidoglycan amidase; EC 3.5.1.28) is an autolysin that hydrolyzes the amide bond between N-acetylmuramoyl and L-amino...; Region: MurNAc-LAA; cd02696 508765001711 active site 508765001712 metal binding site [ion binding]; metal-binding site 508765001713 Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118 508765001714 FOG: LysM repeat [Cell envelope biogenesis, outer membrane]; Region: LytE; COG1388 508765001715 Predicted hydrolase (metallo-beta-lactamase superfamily) [General function prediction only]; Region: ComEC; COG2333 508765001716 Metallo-beta-lactamase superfamily; Region: Lactamase_B; smart00849 508765001717 Protein of unknown function (DUF2922); Region: DUF2922; pfam11148 508765001718 Protein of unknown function (DUF1659); Region: DUF1659; pfam07872 508765001719 NTF2-like N-terminal transpeptidase domain; Region: MecA_N; pfam05223 508765001720 penicillin-binding protein 2; Region: pbp2_mrdA; TIGR03423 508765001721 Penicillin-binding Protein dimerisation domain; Region: PBP_dimer; pfam03717 508765001722 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; pfam00905 508765001723 Tetratricopeptide repeat; Region: TPR_12; pfam13424 508765001724 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 508765001725 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 508765001726 metal binding site [ion binding]; metal-binding site 508765001727 active site 508765001728 I-site; other site 508765001729 Chitinase [Carbohydrate transport and metabolism]; Region: ChiA; COG3325 508765001730 The GH18 (glycosyl hydrolases, family 18) type II chitinases hydrolyze chitin, an abundant polymer of N-acetylglucosamine and have been identified in bacteria, fungi, insects, plants, viruses, and protozoan parasites. The structure of this domain is an...; Region: GH18_chitinase; cd06548 508765001731 active site 508765001732 Chitinase C; Region: ChiC; pfam06483 508765001733 Domain present in phytochromes and cGMP-specific phosphodiesterases; Region: GAF; smart00065 508765001734 Transcriptional regulator containing PAS, AAA-type ATPase, and DNA-binding domains [Transcription / Signal transduction mechanisms]; Region: RocR; COG3829 508765001735 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 508765001736 Walker A motif; other site 508765001737 ATP binding site [chemical binding]; other site 508765001738 Walker B motif; other site 508765001739 arginine finger; other site 508765001740 Bacterial regulatory protein, Fis family; Region: HTH_8; pfam02954 508765001741 peptidase; Reviewed; Region: PRK13004 508765001742 M20 Peptidases with similarity to acetylornithine deacetylases and succinyl-diaminopimelate desuccinylases; Region: M20_ArgE_DapE_like4; cd05649 508765001743 putative metal binding site [ion binding]; other site 508765001744 putative dimer interface [polypeptide binding]; other site 508765001745 aspartate/ornithine carbamoyltransferase family protein; Validated; Region: PRK07200 508765001746 Aspartate/ornithine carbamoyltransferase, carbamoyl-P binding domain; Region: OTCace_N; pfam02729 508765001747 Aspartate/ornithine carbamoyltransferase, Asp/Orn binding domain; Region: OTCace; pfam00185 508765001748 carbamate kinase; Reviewed; Region: PRK12686 508765001749 AAK_CK: Carbamate kinase (CK) catalyzes both the ATP-phosphorylation of carbamate and carbamoyl phosphate (CP) utilization with the production of ATP from ADP and CP. Both CK (this CD) and nonhomologous CP synthetase synthesize carbamoyl phosphate, an...; Region: AAK_CK; cd04235 508765001750 putative substrate binding site [chemical binding]; other site 508765001751 nucleotide binding site [chemical binding]; other site 508765001752 nucleotide binding site [chemical binding]; other site 508765001753 homodimer interface [polypeptide binding]; other site 508765001754 Pyridoxal-phosphate dependent enzyme; Region: PALP; pfam00291 508765001755 Tryptophan synthase beta superfamily (fold type II); this family of pyridoxal phosphate (PLP)-dependent enzymes catalyzes beta-replacement and beta-elimination reactions. This CD corresponds to aminocyclopropane-1-carboxylate deaminase (ACCD), tryptophan...; Region: Trp-synth-beta_II; cd00640 508765001756 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 508765001757 catalytic residue [active] 508765001758 putative chlorohydrolase/aminohydrolase; Validated; Region: PRK07203 508765001759 TRZ/ATZ family contains enzymes from the atrazine degradation pathway and related hydrolases. Atrazine, a chlorinated herbizide, can be catabolized by a variety of different bacteria. The first three steps of the atrazine dehalogenation pathway are...; Region: ATZ_TRZ_like; cd01298 508765001760 active site 508765001761 putative substrate binding pocket [chemical binding]; other site 508765001762 Uncharacterized BCR, YitT family COG1284; Region: DUF161; pfam02588 508765001763 Predicted membrane protein [Function unknown]; Region: COG2364 508765001764 hydroxydechloroatrazine ethylaminohydrolase; Reviewed; Region: PRK08203 508765001765 TRZ/ATZ family contains enzymes from the atrazine degradation pathway and related hydrolases. Atrazine, a chlorinated herbizide, can be catabolized by a variety of different bacteria. The first three steps of the atrazine dehalogenation pathway are...; Region: ATZ_TRZ_like; cd01298 508765001766 active site 508765001767 putative substrate binding pocket [chemical binding]; other site 508765001768 dihydropyrimidine dehydrogenase subunit B; Validated; Region: PRK08318 508765001769 Dihydroorotate dehydrogenase (DHOD) and Dihydropyrimidine dehydrogenase (DHPD) FMN-binding domain. DHOD catalyzes the oxidation of (S)-dihydroorotate to orotate. This is the fourth step and the only redox reaction in the de novo biosynthesis of UMP, the...; Region: DHOD_DHPD_FMN; cd02810 508765001770 active site 508765001771 FMN binding site [chemical binding]; other site 508765001772 substrate binding site [chemical binding]; other site 508765001773 4Fe-4S binding domain; Region: Fer4; pfam00037 508765001774 YjgF, YER057c, and UK114 belong to a large family of proteins present in bacteria, archaea, and eukaryotes with no definitive function. The conserved domain is similar in structure to chorismate mutase but there is no sequence similarity and no...; Region: YjgF_YER057c_UK114_family; cd00448 508765001775 homotrimer interaction site [polypeptide binding]; other site 508765001776 putative active site [active] 508765001777 NTPase; Region: NTPase_1; cl17478 508765001778 selenium-dependent molybdenum hydroxylase 1; Region: Se_dep_Molyb_1; TIGR03311 508765001779 2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207 508765001780 catalytic loop [active] 508765001781 2Fe-2S iron-sulfur cluster binding domain; Region: Fer2_3; pfam13085 508765001782 iron binding site [ion binding]; other site 508765001783 [2Fe-2S] binding domain; Region: Fer2_2; pfam01799 508765001784 Aldehyde oxidase and xanthine dehydrogenase, a/b hammerhead domain; Region: Ald_Xan_dh_C; smart01008 508765001785 Molybdopterin-binding domain of aldehyde dehydrogenase; Region: Ald_Xan_dh_C2; pfam02738 508765001786 Solute carrier families 5 and 6-like; solute binding domain; Region: SLC5-6-like_sbd; cl00456 508765001787 phenylhydantoinase; Validated; Region: PRK08323 508765001788 D-hydantoinases (D-HYD) also called dihydropyrimidases (DHPase) and related proteins; DHPases are a family of enzymes that catalyze the reversible hydrolytic ring opening of the amide bond in five- or six-membered cyclic diamides, like dihydropyrimidine...; Region: D-HYD; cd01314 508765001789 tetramer interface [polypeptide binding]; other site 508765001790 active site 508765001791 Nucleoside deaminases include adenosine, guanine and cytosine deaminases. These enzymes are Zn dependent and catalyze the deamination of nucleosides. The zinc ion in the active site plays a central role in the proposed catalytic mechanism, activating a...; Region: nucleoside_deaminase; cd01285 508765001792 nucleoside/Zn binding site; other site 508765001793 dimer interface [polypeptide binding]; other site 508765001794 catalytic motif [active] 508765001795 xanthine dehydrogenase subunit XdhA; Provisional; Region: PRK09970 508765001796 Aldehyde oxidase and xanthine dehydrogenase, a/b hammerhead domain; Region: Ald_Xan_dh_C; smart01008 508765001797 Molybdopterin-binding domain of aldehyde dehydrogenase; Region: Ald_Xan_dh_C2; pfam02738 508765001798 xanthine dehydrogenase subunit XdhB; Provisional; Region: PRK09971 508765001799 CO dehydrogenase flavoprotein C-terminal domain; Region: CO_deh_flav_C; smart01092 508765001800 Aerobic-type carbon monoxide dehydrogenase, small subunit CoxS/CutS homologs [Energy production and conversion]; Region: CoxS; COG2080 508765001801 2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207 508765001802 catalytic loop [active] 508765001803 iron binding site [ion binding]; other site 508765001804 [2Fe-2S] binding domain; Region: Fer2_2; pfam01799 508765001805 xanthine permease; Region: pbuX; TIGR03173 508765001806 ABC-type Fe3+-hydroxamate transport system, periplasmic component [Inorganic ion transport and metabolism]; Region: FepB; COG0614 508765001807 Helical backbone metal receptor (TroA-like domain). These proteins have been shown to function in the ABC transport of ferric siderophores and metal ions such as Mn2+, Fe3+, Cu2+ and/or Zn2+. Their ligand binding site is formed in the interface between...; Region: TroA-like; cl00262 508765001808 intersubunit interface [polypeptide binding]; other site 508765001809 iron-hydroxamate transporter permease subunit; Provisional; Region: PRK10577 508765001810 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550 508765001811 ABC-ATPase subunit interface; other site 508765001812 dimer interface [polypeptide binding]; other site 508765001813 putative PBP binding regions; other site 508765001814 ABC-type cobalt transport system, ATPase component [Inorganic ion transport and metabolism]; Region: CbiO; COG1122 508765001815 ATP-binding component of iron-siderophores, vitamin B12 and hemin transporters and related proteins; Region: ABC_Iron-Siderophores_B12_Hemin; cd03214 508765001816 Walker A/P-loop; other site 508765001817 ATP binding site [chemical binding]; other site 508765001818 Q-loop/lid; other site 508765001819 ABC transporter signature motif; other site 508765001820 Walker B; other site 508765001821 D-loop; other site 508765001822 H-loop/switch region; other site 508765001823 probable selenium-dependent hydroxylase accessory protein YqeC; Region: TIGR03172 508765001824 selenium-dependent molybdenum hydroxylase system protein, YqeB family; Region: matur_yqeB; TIGR03309 508765001825 M14 family of metallocarboxypeptidases and related proteins; Region: Peptidase_M14_like; cl11393 508765001826 SirA_like_N, a protein of unknown function with an N-terminal SirA-like domain. The SirA, YedF, YeeD protein family is present in bacteria as well as archaea. SirA (also known as UvrY, and YhhP) belongs to a family of a two-component response...; Region: SirA_like_N; cd03421 508765001827 selenium metabolism protein YedF; Region: selenium_YedF; TIGR03527 508765001828 CPxP motif; other site 508765001829 DsrE/DsrF-like family; Region: DrsE; pfam02635 508765001830 selenophosphate synthetase; Provisional; Region: PRK00943 508765001831 Selenophosphate synthetase (SelD) catalyzes the conversion of selenium to selenophosphate which is required by a number of bacterial, archaeal and eukaryotic organisms for synthesis of Secys-tRNA, the precursor of selenocysteine in selenoenzymes. The...; Region: SelD; cd02195 508765001832 dimerization interface [polypeptide binding]; other site 508765001833 putative ATP binding site [chemical binding]; other site 508765001834 BadF/BadG/BcrA/BcrD ATPase family; Region: BcrAD_BadFG; cl17271 508765001835 GT_2_like_f is a subfamily of the glycosyltransferase family 2 (GT-2) with unknown function; Region: GT_2_like_f; cd04182 508765001836 Ligand binding site; other site 508765001837 metal-binding site 508765001838 Xanthine and CO dehydrogenases maturation factor, XdhC/CoxF family [Posttranslational modification, protein turnover, chaperones]; Region: XdhC; COG1975 508765001839 XdhC Rossmann domain; Region: XdhC_C; pfam13478 508765001840 XdhC and CoxI family; Region: XdhC_CoxI; pfam02625 508765001841 cobalt ABC transporter, permease protein CbiQ; Region: CbiQ_TIGR; TIGR02454 508765001842 cobalt transporter ATP-binding subunit; Provisional; Region: cbiO; PRK13639 508765001843 First domain of the ATP-binding cassette component of cobalt transport system; Region: ABC_cobalt_CbiO_domain1; cd03225 508765001844 Walker A/P-loop; other site 508765001845 ATP binding site [chemical binding]; other site 508765001846 Q-loop/lid; other site 508765001847 ABC transporter signature motif; other site 508765001848 Walker B; other site 508765001849 D-loop; other site 508765001850 H-loop/switch region; other site 508765001851 cobalt transport protein CbiM; Validated; Region: PRK08319 508765001852 Cobalt uptake substrate-specific transmembrane region; Region: CbiM; pfam01891 508765001853 cobalt transport protein CbiN; Provisional; Region: PRK02898 508765001854 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 508765001855 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 508765001856 Phytoene dehydrogenase and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG1233 508765001857 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450 508765001858 Flavodoxin reductases (ferredoxin-NADPH reductases) family 1 [Energy production and conversion]; Region: Hmp; COG1018 508765001859 Iron-sulfur binding ferredoxin reductase (FNR) proteins combine the FAD and NAD(P) binding regions of FNR with an iron-sulfur binding cluster domain. Ferredoxin-NADP+ (oxido)reductase is an FAD-containing enzyme that catalyzes the reversible electron...; Region: FNR_iron_sulfur_binding_3; cd06217 508765001860 FAD binding pocket [chemical binding]; other site 508765001861 FAD binding motif [chemical binding]; other site 508765001862 phosphate binding motif [ion binding]; other site 508765001863 beta-alpha-beta structure motif; other site 508765001864 NAD binding pocket [chemical binding]; other site 508765001865 2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207 508765001866 Ferredoxin [Energy production and conversion]; Region: Fdx; COG0633 508765001867 catalytic loop [active] 508765001868 iron binding site [ion binding]; other site 508765001869 DNA-binding transcriptional regulator DhaR; Provisional; Region: PRK11388 508765001870 PAS domain; Region: PAS; smart00091 508765001871 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 508765001872 Walker A motif; other site 508765001873 ATP binding site [chemical binding]; other site 508765001874 Walker B motif; other site 508765001875 arginine finger; other site 508765001876 Bacterial regulatory protein, Fis family; Region: HTH_8; pfam02954 508765001877 Threonine dehydrogenase and related Zn-dependent dehydrogenases [Amino acid transport and metabolism / General function prediction only]; Region: Tdh; COG1063 508765001878 (2R,3R)-2,3-butanediol dehydrogenase; Region: butanediol_DH_like; cd08233 508765001879 putative NAD(P) binding site [chemical binding]; other site 508765001880 catalytic Zn binding site [ion binding]; other site 508765001881 ferredoxin-NADP(+) reductase subunit alpha; Reviewed; Region: PRK06222 508765001882 FAD/NAD binding domain in the electron transfer subunit of dihydroorotate dehydrogenase-like proteins. Dihydroorotate dehydrogenases (DHODs) catalyze the only redox reaction in pyrimidine de novo biosynthesis. They catalyze the oxidation of (S)...; Region: DHOD_e_trans_like1; cd06219 508765001883 FAD binding pocket [chemical binding]; other site 508765001884 FAD binding motif [chemical binding]; other site 508765001885 phosphate binding motif [ion binding]; other site 508765001886 beta-alpha-beta structure motif; other site 508765001887 NAD binding pocket [chemical binding]; other site 508765001888 Iron coordination center [ion binding]; other site 508765001889 putative oxidoreductase; Provisional; Region: PRK12831 508765001890 The HCP family of iron-sulfur proteins includes hybrid cluster protein (HCP), acetyl-CoA synthase (ACS), and carbon monoxide dehydrogenase (CODH), all of which contain [Fe4-S4] metal clusters at their active sites. These proteins have a conserved...; Region: HCP_like; cl14655 508765001891 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500 508765001892 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 508765001893 Four helix bundle sensory module for signal transduction; Region: 4HB_MCP_1; pfam12729 508765001894 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 508765001895 dimerization interface [polypeptide binding]; other site 508765001896 Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer); Region: MA; smart00283 508765001897 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 508765001898 dimer interface [polypeptide binding]; other site 508765001899 putative CheW interface [polypeptide binding]; other site 508765001900 cyclophilin: cyclophilin-type peptidylprolyl cis- trans isomerases. This family contains eukaryotic, bacterial and archeal proteins which exhibit a peptidylprolyl cis- trans isomerases activity (PPIase, Rotamase) and in addition bind the...; Region: cyclophilin; cd00317 508765001901 active site 508765001902 Predicted membrane protein [Function unknown]; Region: COG3619 508765001903 Acetyltransferase (GNAT) domain; Region: Acetyltransf_3; pfam13302 508765001904 short chain dehydrogenase; Provisional; Region: PRK06701 508765001905 classical (c) SDR, subgroup 1; Region: SDR_c1; cd05355 508765001906 NAD binding site [chemical binding]; other site 508765001907 metal binding site [ion binding]; metal-binding site 508765001908 active site 508765001909 Putative lysophospholipase; Region: Hydrolase_4; pfam12146 508765001910 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 508765001911 Novel bacterial esterase that cleaves esters on halogenated cyclic compounds; Region: Esterase_713_like; cl17303 508765001912 3-oxoacyl-[acyl-carrier-protein]; Region: FabH; COG0332 508765001913 Condensing enzymes; Family of enzymes that catalyze a (decarboxylating or non-decarboxylating) Claisen-like condensation reaction. Members are share strong structural similarity, and are involved in the synthesis and degradation of fatty acids, and the...; Region: cond_enzymes; cl09938 508765001914 active site 508765001915 Nucleotidyltransferase domain; Region: NTP_transf_2; pfam01909 508765001916 YjgF, YER057c, and UK114 belong to a large family of proteins present in bacteria, archaea, and eukaryotes with no definitive function. The conserved domain is similar in structure to chorismate mutase but there is no sequence similarity and no...; Region: YjgF_YER057c_UK114_family; cd00448 508765001917 homotrimer interaction site [polypeptide binding]; other site 508765001918 putative active site [active] 508765001919 Protein of unknown function (DUF3892); Region: DUF3892; pfam13031 508765001920 ABC-type Na+ transport system, ATPase component [Energy production and conversion / Inorganic ion transport and metabolism]; Region: NatA; COG4555 508765001921 ATP-binding cassette domain of the drug resistance transporter and related proteins, subfamily A; Region: ABC_DR_subfamily_A; cd03230 508765001922 Walker A/P-loop; other site 508765001923 ATP binding site [chemical binding]; other site 508765001924 Q-loop/lid; other site 508765001925 ABC transporter signature motif; other site 508765001926 Walker B; other site 508765001927 D-loop; other site 508765001928 H-loop/switch region; other site 508765001929 Predicted transcriptional regulators [Transcription]; Region: COG1725 508765001930 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 508765001931 DNA-binding site [nucleotide binding]; DNA binding site 508765001932 Ferredoxin [Energy production and conversion]; Region: COG1146 508765001933 4Fe-4S binding domain; Region: Fer4_6; pfam12837 508765001934 D-alanyl-lipoteichoic acid biosynthesis protein DltD; Region: LTA_DltD; TIGR04092 508765001935 DltD central region; Region: DltD_M; pfam04918 508765001936 DltD C-terminal region; Region: DltD_C; pfam04914 508765001937 D-alanine--poly(phosphoribitol) ligase subunit 1; Provisional; Region: PRK04813 508765001938 D-alanine:D-alanyl carrier protein ligase (DltA); Region: DltA; cd05945 508765001939 acyl-activating enzyme (AAE) consensus motif; other site 508765001940 AMP binding site [chemical binding]; other site 508765001941 D-alanyl-lipoteichoic acid biosynthesis protein DltB; Region: LTA_dltB; TIGR04091 508765001942 Phosphopantetheine attachment site; Region: PP-binding; cl09936 508765001943 AraC-like ligand binding domain; Region: AraC_binding; pfam02311 508765001944 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 508765001945 Glycosyl hydrolases family 39; Region: Glyco_hydro_39; pfam01229 508765001946 NADPH-dependent FMN reductase; Region: FMN_red; pfam03358 508765001947 Multimeric flavodoxin WrbA [General function prediction only]; Region: WrbA; COG0655 508765001948 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 508765001949 Major Facilitator Superfamily; Region: MFS_1; pfam07690 508765001950 putative substrate translocation pore; other site 508765001951 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 508765001952 Acyl CoA:acetate/3-ketoacid CoA transferase, alpha subunit [Lipid metabolism]; Region: AtoD; COG1788 508765001953 3-oxoacid CoA-transferase, B subunit; Region: pcaJ_scoB_fam; TIGR02428 508765001954 Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673 508765001955 Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408 508765001956 Suppressor of fused protein (SUFU); Region: SUFU; pfam05076 508765001957 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 508765001958 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 508765001959 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 508765001960 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3708 508765001961 effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038 508765001962 cAMP-binding proteins - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases [Signal transduction mechanisms]; Region: Crp; COG0664 508765001963 ligand binding site [chemical binding]; other site 508765001964 flexible hinge region; other site 508765001965 helix_turn_helix, cAMP Regulatory protein C-terminus; DNA binding domain of prokaryotic regulatory proteins belonging to the catabolite activator protein family; Region: HTH_CRP; cd00092 508765001966 putative switch regulator; other site 508765001967 non-specific DNA interactions [nucleotide binding]; other site 508765001968 DNA binding site [nucleotide binding] 508765001969 sequence specific DNA binding site [nucleotide binding]; other site 508765001970 putative cAMP binding site [chemical binding]; other site 508765001971 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 508765001972 Major Facilitator Superfamily; Region: MFS_1; pfam07690 508765001973 putative substrate translocation pore; other site 508765001974 Flavodoxin-like fold; Region: Flavodoxin_2; cl00438 508765001975 Uncharacterized flavoproteins [Energy production and conversion]; Region: FpaA; COG0426 508765001976 Protein of unknown function (DUF3793); Region: DUF3793; pfam12672 508765001977 Soluble lytic murein transglycosylase and related regulatory proteins (some contain LysM/invasin domains) [Cell envelope biogenesis, outer membrane]; Region: MltE; COG0741 508765001978 Lytic Transglycosylase (LT) and Goose Egg White Lysozyme (GEWL) domain. Members include the soluble and insoluble membrane-bound LTs in bacteria, the LTs in bacteriophage lambda, as well as, the eukaryotic "goose-type" lysozymes (GEWL). LTs...; Region: LT_GEWL; cd00254 508765001979 N-acetyl-D-glucosamine binding site [chemical binding]; other site 508765001980 catalytic residue [active] 508765001981 Predicted HD-superfamily hydrolase [General function prediction only]; Region: COG3481 508765001982 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 508765001983 Zn2+ binding site [ion binding]; other site 508765001984 Mg2+ binding site [ion binding]; other site 508765001985 endonuclease IV; Provisional; Region: PRK01060 508765001986 AP endonuclease family 2; These endonucleases play a role in DNA repair. Cleave phosphodiester bonds at apurinic or apyrimidinic sites; the alignment also contains hexulose-6-phosphate isomerases, enzymes that catalyze the epimerization of...; Region: AP2Ec; cd00019 508765001987 AP (apurinic/apyrimidinic) site pocket; other site 508765001988 DNA interaction; other site 508765001989 Metal-binding active site; metal-binding site 508765001990 Glycine/D-amino acid oxidases (deaminating) [Amino acid transport and metabolism]; Region: DadA; COG0665 508765001991 putative aminophosphonate oxidoreductase; Region: Phn_aa_oxid; TIGR03329 508765001992 Putative peptidoglycan binding domain; Region: PG_binding_4; pfam12229 508765001993 Putative peptidoglycan binding domain; Region: PG_binding_4; pfam12229 508765001994 L,D-transpeptidase catalytic domain; Region: YkuD; pfam03734 508765001995 Uncharacterized protein conserved in bacteria [Function unknown]; Region: ErfK; COG1376 508765001996 Transcriptional regulators [Transcription]; Region: PhnF; COG2188 508765001997 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 508765001998 DNA-binding site [nucleotide binding]; DNA binding site 508765001999 UTRA domain; Region: UTRA; pfam07702 508765002000 N-acetylglucosamine-6-phosphate deacetylase [Carbohydrate transport and metabolism]; Region: NagA; COG1820 508765002001 N-acetylglucosamine-6-phosphate deacetylase, NagA, catalyzes the hydrolysis of the N-acetyl group of N-acetyl-glucosamine-6-phosphate (GlcNAc-6-P) to glucosamine 6-phosphate and acetate. This is the first committed step in the biosynthetic pathway to...; Region: NagA; cd00854 508765002002 active site 508765002003 dimer interface [polypeptide binding]; other site 508765002004 6-phosphogluconolactonase/Glucosamine-6-phosphate isomerase/deaminase [Carbohydrate transport and metabolism]; Region: NagB; COG0363 508765002005 GlcN6P_deaminase: Glucosamine-6-phosphate (GlcN6P) deaminase subfamily; GlcN6P deaminase catalyzes the reversible conversion of GlcN6P to D-fructose-6-phosphate (Fru6P) and ammonium. The reaction is an aldo-keto isomerization coupled with an amination or...; Region: GlcN6P_deaminase; cd01399 508765002006 active site 508765002007 trimer interface [polypeptide binding]; other site 508765002008 allosteric site; other site 508765002009 active site lid [active] 508765002010 hexamer (dimer of trimers) interface [polypeptide binding]; other site 508765002011 PTS system, N-acetylglucosamine-specific IIBC component; Region: PTS-II-BC-nag; TIGR01998 508765002012 Phosphotransferase system IIC components, glucose/maltose/N-acetylglucosamine-specific [Carbohydrate transport and metabolism]; Region: PtsG; COG1263 508765002013 PTS_IIB, PTS system, glucose/sucrose specific IIB subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIB_glc; cd00212 508765002014 active site turn [active] 508765002015 phosphorylation site [posttranslational modification] 508765002016 CutC family; Region: CutC; cl01218 508765002017 Uncharacterized conserved protein [General function prediction only]; Region: BioY; COG1268 508765002018 biotin synthase; Region: bioB; TIGR00433 508765002019 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 508765002020 FeS/SAM binding site; other site 508765002021 Biotin and Thiamin Synthesis associated domain; Region: BATS; pfam06968 508765002022 AAA domain; Region: AAA_26; pfam13500 508765002023 dithiobiotin synthetase; Reviewed; Region: bioD; PRK00090 508765002024 Predicted transcriptional regulators [Transcription]; Region: SoxR; COG0789 508765002025 Helix-Turn-Helix DNA binding domain of the BltR transcription regulator; Region: HTH_BltR; cd04782 508765002026 DNA binding residues [nucleotide binding] 508765002027 dimer interface [polypeptide binding]; other site 508765002028 Transcriptional regulator, effector-binding domain/component [Transcription / Signal transduction mechanisms]; Region: COG4978 508765002029 ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132 508765002030 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 508765002031 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 508765002032 Walker A/P-loop; other site 508765002033 ATP binding site [chemical binding]; other site 508765002034 Q-loop/lid; other site 508765002035 ABC transporter signature motif; other site 508765002036 Walker B; other site 508765002037 D-loop; other site 508765002038 H-loop/switch region; other site 508765002039 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 508765002040 ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132 508765002041 ATP-binding cassette domain of glucan transporter and related proteins, subfamily C; Region: ABCC_Glucan_exporter_like; cd03254 508765002042 Walker A/P-loop; other site 508765002043 ATP binding site [chemical binding]; other site 508765002044 Q-loop/lid; other site 508765002045 ABC transporter signature motif; other site 508765002046 Walker B; other site 508765002047 D-loop; other site 508765002048 H-loop/switch region; other site 508765002049 Acetolactate synthase, small (regulatory) subunit [Amino acid transport and metabolism]; Region: IlvH; COG0440 508765002050 N-terminal ACT domain of the Escherichia coli IlvH-like regulatory subunit of acetohydroxyacid synthase (AHAS); Region: ACT_AHAS; cd04878 508765002051 putative valine binding site [chemical binding]; other site 508765002052 dimer interface [polypeptide binding]; other site 508765002053 acetolactate synthase catalytic subunit; Validated; Region: PRK08155 508765002054 Pyrimidine (PYR) binding domain of POX and related proteins; Region: TPP_PYR_POX_like; cd07035 508765002055 PYR/PP interface [polypeptide binding]; other site 508765002056 dimer interface [polypeptide binding]; other site 508765002057 TPP binding site [chemical binding]; other site 508765002058 Thiamine pyrophosphate enzyme, central domain; Region: TPP_enzyme_M; pfam00205 508765002059 Thiamine pyrophosphate (TPP) family, Acetohydroxyacid synthase (AHAS) subfamily, TPP-binding module; composed of proteins similar to the large catalytic subunit of AHAS. AHAS catalyzes the condensation of two molecules of pyruvate to give the...; Region: TPP_AHAS; cd02015 508765002060 TPP-binding site [chemical binding]; other site 508765002061 dimer interface [polypeptide binding]; other site 508765002062 CarD-like/TRCF domain; Region: CarD_CdnL_TRCF; cl00588 508765002063 Probable zinc-binding domain; Region: zf-trcl; pfam13451 508765002064 Fusaric acid resistance protein-like; Region: FUSC_2; pfam13515 508765002065 T-box leader 508765002066 Branched-chain amino acid transport protein; Region: Branch_AA_trans; pfam05525 508765002067 cAMP-binding proteins - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases [Signal transduction mechanisms]; Region: Crp; COG0664 508765002068 effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038 508765002069 ligand binding site [chemical binding]; other site 508765002070 Transcriptional regulators of sugar metabolism [Transcription / Carbohydrate transport and metabolism]; Region: GlpR; COG1349 508765002071 helix_turn_helix, Deoxyribose operon repressor; Region: HTH_DEOR; smart00420 508765002072 DeoR C terminal sensor domain; Region: DeoRC; pfam00455 508765002073 2-deoxyribose-5-phosphate aldolase (DERA) of the DeoC family; Region: DeoC; cd00959 508765002074 intersubunit interface [polypeptide binding]; other site 508765002075 active site 508765002076 catalytic residue [active] 508765002077 Glycosyl transferase family, helical bundle domain; Region: Glycos_trans_3N; pfam02885 508765002078 pyrimidine-nucleoside phosphorylase; Region: Y_phosphoryl; TIGR02644 508765002079 Glycosyl transferase family, a/b domain; Region: Glycos_transf_3; pfam00591 508765002080 Pyrimidine nucleoside phosphorylase C-terminal domain; Region: PYNP_C; smart00941 508765002081 hybrid cluster protein; Provisional; Region: PRK05290 508765002082 The HCP family of iron-sulfur proteins includes hybrid cluster protein (HCP), acetyl-CoA synthase (ACS), and carbon monoxide dehydrogenase (CODH), all of which contain [Fe4-S4] metal clusters at their active sites. These proteins have a conserved...; Region: HCP_like; cl14655 508765002083 ACS interaction site; other site 508765002084 CODH interaction site; other site 508765002085 Hybrid cluster protein (HCP), formerly known as prismane, is thought to play a role in nitrogen metabolism but its specific function is unknown. HCP has three structural domains, an N-terminal alpha-helical domain, and two similar domains comprising a...; Region: HCP; cd01914 508765002086 hybrid metal cluster; other site 508765002087 Predicted membrane protein [Function unknown]; Region: COG2364 508765002088 Accessory gene regulator B; Region: AgrB; pfam04647 508765002089 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 508765002090 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 508765002091 ATP binding site [chemical binding]; other site 508765002092 Mg2+ binding site [ion binding]; other site 508765002093 G-X-G motif; other site 508765002094 ABC-type metal ion transport system, ATPase component [Inorganic ion transport and metabolism]; Region: AbcC; COG1135 508765002095 ATP-binding cassette domain of methionine transporter; Region: ABC_MetN_methionine_transporter; cd03258 508765002096 Walker A/P-loop; other site 508765002097 ATP binding site [chemical binding]; other site 508765002098 Q-loop/lid; other site 508765002099 ABC transporter signature motif; other site 508765002100 Walker B; other site 508765002101 D-loop; other site 508765002102 H-loop/switch region; other site 508765002103 This domain is found at the C-terminus of ABC transporter proteins involved in D-methionine transport as well as a number of ferredoxin-like proteins; Region: NIL; smart00930 508765002104 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 508765002105 dimer interface [polypeptide binding]; other site 508765002106 conserved gate region; other site 508765002107 ABC-ATPase subunit interface; other site 508765002108 ABC-type metal ion transport system, periplasmic component/surface antigen [Inorganic ion transport and metabolism]; Region: NlpA; COG1464 508765002109 NLPA lipoprotein; Region: Lipoprotein_9; pfam03180 508765002110 Uncharacterized conserved protein [Function unknown]; Region: COG3339 508765002111 Caulimovirus viroplasmin; Region: Cauli_VI; pfam01693 508765002112 Bacterial RNase HI containing a hybrid binding domain (HBD) at the N-terminus; Region: RNase_HI_bacteria_HBD; cd09277 508765002113 RNA/DNA hybrid binding site [nucleotide binding]; other site 508765002114 active site 508765002115 YtxH-like protein; Region: YtxH; pfam12732 508765002116 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 508765002117 sequence-specific DNA binding site [nucleotide binding]; other site 508765002118 salt bridge; other site 508765002119 Tetratricopeptide repeat; Region: TPR_12; pfam13424 508765002120 Tetratricopeptide repeat; Region: TPR_12; pfam13424 508765002121 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 508765002122 non-specific DNA binding site [nucleotide binding]; other site 508765002123 salt bridge; other site 508765002124 sequence-specific DNA binding site [nucleotide binding]; other site 508765002125 Tetratricopeptide repeat; Region: TPR_12; pfam13424 508765002126 Tetratricopeptide repeat; Region: TPR_12; pfam13424 508765002127 ATP-dependent chaperone ClpB; Region: chaperone_ClpB; TIGR03346 508765002128 Clp amino terminal domain; Region: Clp_N; pfam02861 508765002129 Clp amino terminal domain; Region: Clp_N; pfam02861 508765002130 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 508765002131 Walker A motif; other site 508765002132 ATP binding site [chemical binding]; other site 508765002133 Walker B motif; other site 508765002134 arginine finger; other site 508765002135 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 508765002136 Walker A motif; other site 508765002137 ATP binding site [chemical binding]; other site 508765002138 Walker B motif; other site 508765002139 arginine finger; other site 508765002140 C-terminal, D2-small domain, of ClpB protein; Region: ClpB_D2-small; pfam10431 508765002141 Small, acid-soluble spore proteins, alpha/beta type; Region: SASP; pfam00269 508765002142 nylC-like family; composed of proteins with similarity to Flavobacterium endo-type 6-aminohexanoate-oligomer hydrolase (EIII), the product of the nylon oligomer degradation gene, nylC. EIII is an amide hydrolase that catalyzes the degradation of...; Region: nylC_like; cd02252 508765002143 putative active site pocket [active] 508765002144 cleavage site 508765002145 Predicted membrane protein [Function unknown]; Region: COG4684 508765002146 Protein of unknown function (DUF3816); Region: DUF3816; pfam12822 508765002147 NAD synthetase; Reviewed; Region: nadE; cl17435 508765002148 This is a subfamily of Adenine nucleotide alpha hydrolases superfamily.Adeninosine nucleotide alpha hydrolases superfamily includes N type ATP PPases and ATP sulphurylases. It forms a apha/beta/apha fold which binds to Adenosine group. This subfamily; Region: Alpha_ANH_like_II; cd01993 508765002149 Ligand Binding Site [chemical binding]; other site 508765002150 Domain of unknown function (DUF4250); Region: DUF4250; pfam14056 508765002151 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 508765002152 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 508765002153 metal binding site [ion binding]; metal-binding site 508765002154 active site 508765002155 I-site; other site 508765002156 EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2). The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948 508765002157 T-box leader 508765002158 Predicted xylanase/chitin deacetylase [Carbohydrate transport and metabolism]; Region: CDA1; COG0726 508765002159 Catalytic NodB homology domain of Streptococcus mutans polysaccharide deacetylase PgdA, Bacillus subtilis YheN, and similar proteins; Region: CE4_SmPgdA_like; cd10944 508765002160 NodB motif; other site 508765002161 active site 508765002162 catalytic site [active] 508765002163 Zn binding site [ion binding]; other site 508765002164 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 508765002165 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 508765002166 metal binding site [ion binding]; metal-binding site 508765002167 active site 508765002168 I-site; other site 508765002169 GAF domain; Region: GAF_3; pfam13492 508765002170 GAF domain; Region: GAF_2; pfam13185 508765002171 Cna protein B-type domain; Region: Cna_B; pfam05738 508765002172 Trimeric dUTP diphosphatases; Region: trimeric_dUTPase; cd07557 508765002173 trimer interface [polypeptide binding]; other site 508765002174 active site 508765002175 ATPase components of ABC transporters with duplicated ATPase domains [General function prediction only]; Region: Uup; COG0488 508765002176 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 508765002177 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 508765002178 ABC transporter; Region: ABC_tran_2; pfam12848 508765002179 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 508765002180 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 508765002181 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 508765002182 Domain of unknown function (DUF4397); Region: DUF4397; pfam14344 508765002183 Domain of unknown function (DUF4397); Region: DUF4397; pfam14344 508765002184 Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321 508765002185 Selenocysteine lyase/Cysteine desulfurase [Posttranslational modification, protein turnover, chaperones]; Region: csdA; COG0520 508765002186 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 508765002187 catalytic residue [active] 508765002188 6-phosphofructokinase; Provisional; Region: PRK14072 508765002189 6-phosphofructokinase; Region: PFKA_ATP; TIGR02482 508765002190 active site 508765002191 ADP/pyrophosphate binding site [chemical binding]; other site 508765002192 dimerization interface [polypeptide binding]; other site 508765002193 allosteric effector site; other site 508765002194 fructose-1,6-bisphosphate binding site; other site 508765002195 Predicted membrane protein [Function unknown]; Region: COG1971 508765002196 ferric uptake regulator; Provisional; Region: fur; PRK09462 508765002197 Ferric uptake regulator(Fur) and related metalloregulatory proteins; typically iron-dependent, DNA-binding repressors and activators; Region: Fur_like; cd07153 508765002198 metal binding site 2 [ion binding]; metal-binding site 508765002199 putative DNA binding helix; other site 508765002200 metal binding site 1 [ion binding]; metal-binding site 508765002201 dimer interface [polypeptide binding]; other site 508765002202 structural Zn2+ binding site [ion binding]; other site 508765002203 ABC-type Mn2+/Zn2+ transport systems, permease components [Inorganic ion transport and metabolism]; Region: ZnuB; COG1108 508765002204 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550 508765002205 ABC-ATPase subunit interface; other site 508765002206 dimer interface [polypeptide binding]; other site 508765002207 putative PBP binding regions; other site 508765002208 ABC-type cobalt transport system, ATPase component [Inorganic ion transport and metabolism]; Region: CbiO; COG1122 508765002209 ATP-binding cassette domain of the metal-type transporters; Region: ABC_Metallic_Cations; cd03235 508765002210 oligoendopeptidase F; Region: pepF; TIGR00181 508765002211 Peptidase family M3B Oligopeptidase F (PepF); Region: M3B_PepF_3; cd09608 508765002212 active site 508765002213 Zn binding site [ion binding]; other site 508765002214 Rhomboid family; Region: Rhomboid; pfam01694 508765002215 glutamate dehydrogenase; Provisional; Region: PRK09414 508765002216 Glu/Leu/Phe/Val dehydrogenase, dimerisation domain; Region: ELFV_dehydrog_N; pfam02812 508765002217 NAD(P) binding domain of glutamate dehydrogenase, subgroup 2; Region: NAD_bind_2_Glu_DH; cd05313 508765002218 NAD(P) binding site [chemical binding]; other site 508765002219 Glycosyltransferase like family 2; Region: Glyco_tranf_2_3; pfam13641 508765002220 EpsO protein participates in the methanolan synthesis; Region: EpsO_like; cd06438 508765002221 DXD motif; other site 508765002222 DNA topoisomerase IV subunit B; Reviewed; Region: PRK05559 508765002223 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 508765002224 ATP binding site [chemical binding]; other site 508765002225 Mg2+ binding site [ion binding]; other site 508765002226 G-X-G motif; other site 508765002227 TopoIIA_Trans_DNA_gyrase: Transducer domain, having a ribosomal S5 domain 2-like fold, of the type found in proteins of the type IIA family of DNA topoisomerases similar to the B subunits of E. coli DNA gyrase and E. coli Topoisomerase IV which are; Region: TopoII_Trans_DNA_gyrase; cd00822 508765002228 anchoring element; other site 508765002229 dimer interface [polypeptide binding]; other site 508765002230 ATP binding site [chemical binding]; other site 508765002231 Topoisomerase-primase domain. This is a nucleotidyl transferase/hydrolase domain found in type IA, type IIA and type IIB topoisomerases, bacterial DnaG-type primases, small primase-like proteins from bacteria and archaea, OLD family nucleases from...; Region: TOPRIM; cl00718 508765002232 active site 508765002233 metal binding site [ion binding]; metal-binding site 508765002234 DNA gyrase B subunit, carboxyl terminus; Region: DNA_gyraseB_C; pfam00986 508765002235 DNA topoisomerase IV subunit A; Provisional; Region: PRK13979 508765002236 DNA Topoisomerase, subtype IIA; domain A'; bacterial DNA topoisomerase IV (C subunit, ParC), bacterial DNA gyrases (A subunit, GyrA),mammalian DNA toposiomerases II. DNA topoisomerases are essential enzymes that regulate the conformational changes...; Region: TOP4c; cd00187 508765002237 CAP-like domain; other site 508765002238 active site 508765002239 primary dimer interface [polypeptide binding]; other site 508765002240 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 508765002241 DJ-1 family protein; Region: not_thiJ; TIGR01383 508765002242 Type 1 glutamine amidotransferase (GATase1)-like domain found in Human DJ-1; Region: GATase1_DJ-1; cd03135 508765002243 conserved cys residue [active] 508765002244 single-stranded-DNA-specific exonuclease RecJ; Region: recJ; TIGR00644 508765002245 DHH family; Region: DHH; pfam01368 508765002246 DHHA1 domain; Region: DHHA1; pfam02272 508765002247 butyryl-CoA:acetate CoA-transferase; Region: butyr_acet_CoA; TIGR03948 508765002248 Acetyl-CoA hydrolase/transferase N-terminal domain; Region: AcetylCoA_hydro; pfam02550 508765002249 Acetyl-CoA hydrolase/transferase C-terminal domain; Region: AcetylCoA_hyd_C; pfam13336 508765002250 Small, acid-soluble spore proteins, alpha/beta type; Region: SASP; pfam00269 508765002251 MurG is an N-acetylglucosaminyltransferase, the last enzyme involved in the intracellular phase of peptidoglycan biosynthesis. It transfers N-acetyl-D-glucosamine (GlcNAc) from UDP-GlcNAc to the C4 hydroxyl of a lipid-linked N-acetylmuramoyl pentapeptide...; Region: GT1_MurG; cd03785 508765002252 undecaprenyldiphospho-muramoylpentapeptide beta-N-acetylglucosaminyltransferase; Reviewed; Region: PRK12446 508765002253 active site 508765002254 homodimer interface [polypeptide binding]; other site 508765002255 flavodoxin; Provisional; Region: PRK05569 508765002256 Uncharacterized flavoproteins [Energy production and conversion]; Region: FpaA; COG0426 508765002257 pyruvate:ferredoxin (flavodoxin) oxidoreductase, homodimeric; Region: pyruv_ox_red; TIGR02176 508765002258 Pyrimidine (PYR) binding domain of pyruvate ferredoxin oxidoreductase (PFOR), indolepyruvate ferredoxin oxidoreductase alpha subunit (IOR-alpha), and related proteins; Region: TPP_PYR_PFOR_IOR-alpha_like; cd07034 508765002259 dimer interface [polypeptide binding]; other site 508765002260 PYR/PP interface [polypeptide binding]; other site 508765002261 TPP binding site [chemical binding]; other site 508765002262 substrate binding site [chemical binding]; other site 508765002263 Pyruvate:ferredoxin oxidoreductase and related 2-oxoacid:ferredoxin oxidoreductases, gamma subunit [Energy production and conversion]; Region: PorG; COG1014 508765002264 Domain of unknown function; Region: EKR; smart00890 508765002265 The HCP family of iron-sulfur proteins includes hybrid cluster protein (HCP), acetyl-CoA synthase (ACS), and carbon monoxide dehydrogenase (CODH), all of which contain [Fe4-S4] metal clusters at their active sites. These proteins have a conserved...; Region: HCP_like; cl14655 508765002266 Thiamine pyrophosphate (TPP family), PFOR_PNO subfamily, TPP-binding module; composed of proteins similar to the single subunit pyruvate ferredoxin oxidoreductase (PFOR) of Desulfovibrio Africanus, present in bacteria and amitochondriate eukaryotes. This...; Region: TPP_PFOR_PNO; cd03377 508765002267 TPP-binding site [chemical binding]; other site 508765002268 dimer interface [polypeptide binding]; other site 508765002269 Protein of unknown function (DUF1292); Region: DUF1292; pfam06949 508765002270 aspartate aminotransferase; Provisional; Region: PRK05764 508765002271 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 508765002272 pyridoxal 5'-phosphate binding site [chemical binding]; other site 508765002273 homodimer interface [polypeptide binding]; other site 508765002274 catalytic residue [active] 508765002275 Phosphoserine phosphatase [Amino acid transport and metabolism]; Region: SerB; COG0560 508765002276 haloacid dehalogenase-like hydrolase; Region: HAD; cl17202 508765002277 Branched-chain amino acid aminotransferase/4-amino-4-deoxychorismate lyase [Amino acid transport and metabolism / Coenzyme metabolism]; Region: IlvE; COG0115 508765002278 PyridoxaL 5'-Phosphate Dependent Enzymes class IV (PLPDE_IV). This D-amino acid superfamily, one of five classes of PLPDE, consists of branched-chain amino acid aminotransferases (BCAT), D-amino acid transferases (DAAT), and...; Region: PLPDE_IV; cd00449 508765002279 substrate-cofactor binding pocket; other site 508765002280 homodimer interface [polypeptide binding]; other site 508765002281 pyridoxal 5'-phosphate binding site [chemical binding]; other site 508765002282 catalytic residue [active] 508765002283 Protein of unknown function (DUF342); Region: DUF342; pfam03961 508765002284 Chemotaxis signal transduction protein [Cell motility and secretion / Signal transduction mechanisms]; Region: CheW; COG0835 508765002285 chemoreceptor glutamine deamidase CheD; Provisional; Region: PRK13490 508765002286 chemotaxis-specific methylesterase; Provisional; Region: PRK00742 508765002287 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 508765002288 active site 508765002289 phosphorylation site [posttranslational modification] 508765002290 intermolecular recognition site; other site 508765002291 dimerization interface [polypeptide binding]; other site 508765002292 CheB methylesterase; Region: CheB_methylest; pfam01339 508765002293 Methylase of chemotaxis methyl-accepting proteins [Cell motility and secretion / Signal transduction mechanisms]; Region: CheR; COG1352 508765002294 CheR methyltransferase, all-alpha domain; Region: CheR_N; pfam03705 508765002295 CheR methyltransferase, SAM binding domain; Region: CheR; pfam01739 508765002296 Chemotaxis protein histidine kinase and related kinases [Cell motility and secretion / Signal transduction mechanisms]; Region: CheA; COG0643 508765002297 Histidine Phosphotransfer domain, involved in signalling through a two part component systems in which an autophosphorylating histidine protein kinase serves as a phosphoryl donor to a response regulator protein; the response regulator protein is...; Region: HPT; cd00088 508765002298 putative binding surface; other site 508765002299 active site 508765002300 P2 response regulator binding domain; Region: P2; pfam07194 508765002301 Signal transducing histidine kinase, homodimeric domain; Region: H-kinase_dim; pfam02895 508765002302 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 508765002303 ATP binding site [chemical binding]; other site 508765002304 Mg2+ binding site [ion binding]; other site 508765002305 G-X-G motif; other site 508765002306 CheA regulatory domain; CheA is a histidine protein kinase present in bacteria and archea. Activated by the chemotaxis receptor a histidine phosphoryl group from CheA is passed directly to an aspartate in the response regulator CheY. This signalling...; Region: CheA_reg; cd00731 508765002307 Chemotaxis protein CheC, inhibitor of MCP methylation [Cell motility and secretion / Signal transduction mechanisms]; Region: CheC; COG1776 508765002308 CheC-like family; Region: CheC; pfam04509 508765002309 CheC-like family; Region: CheC; pfam04509 508765002310 Response regulator receiver domain; Region: Response_reg; pfam00072 508765002311 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 508765002312 active site 508765002313 phosphorylation site [posttranslational modification] 508765002314 intermolecular recognition site; other site 508765002315 dimerization interface [polypeptide binding]; other site 508765002316 CheW-like domain. CheW proteins are part of the chemotaxis signalling mechanism in bacteria. CheW interacts with the methyl accepting chemotaxis proteins (MCPs) and relays signals to CheY, which affects flageller rotation. This family includes CheW and...; Region: CheW_like; cl00256 508765002317 flagellar motor switch protein FliM; Validated; Region: fliM; PRK06666 508765002318 Surface presentation of antigens (SPOA); Region: SpoA; pfam01052 508765002319 flagellar motor switch protein; Validated; Region: PRK08119 508765002320 CheC-like family; Region: CheC; pfam04509 508765002321 CheC-like family; Region: CheC; pfam04509 508765002322 Surface presentation of antigens (SPOA); Region: SpoA; cl00819 508765002323 Anti-sigma-28 factor, FlgM; Region: FlgM; pfam04316 508765002324 FlgN protein; Region: FlgN; pfam05130 508765002325 flagellar hook-associated protein FlgK; Validated; Region: flgK; PRK07739 508765002326 Flagella basal body rod protein; Region: Flg_bb_rod; pfam00460 508765002327 Flagellar basal body rod FlgEFG protein C-terminal; Region: Flg_bbr_C; pfam06429 508765002328 Flagellin and related hook-associated proteins [Cell motility and secretion]; Region: FlgL; COG1344 508765002329 Bacterial flagellin N-terminal helical region; Region: Flagellin_N; pfam00669 508765002330 Bacterial flagellin C-terminal helical region; Region: Flagellin_C; pfam00700 508765002331 flagellar assembly protein FliW; Provisional; Region: PRK13285 508765002332 carbon storage regulator; Provisional; Region: PRK01712 508765002333 FlaG protein; Region: FlaG; pfam03646 508765002334 Flagellin-specific chaperone FliS [Cell motility and secretion / Intracellular trafficking and secretion / Posttranslational modification, protein turnover, chaperones]; Region: FliS; COG1516 508765002335 Flagellar hook-associated protein 2 C-terminus; Region: FliD_N; pfam02465 508765002336 Flagellar hook-associated protein 2 C-terminus; Region: FliD_C; pfam07195 508765002337 Putative motility protein; Region: YjfB_motility; pfam14070 508765002338 flagellin; Provisional; Region: PRK12804 508765002339 Bacterial flagellin N-terminal helical region; Region: Flagellin_N; pfam00669 508765002340 Bacterial flagellin C-terminal helical region; Region: Flagellin_C; pfam00700 508765002341 UDP-glucose LOS-beta-1,4 glucosyltransferase is required for biosynthesis of lipooligosaccharide; Region: Beta4Glucosyltransferase; cd02511 508765002342 putative metal binding site; other site 508765002343 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 508765002344 binding surface 508765002345 TPR motif; other site 508765002346 TPR repeat; Region: TPR_11; pfam13414 508765002347 flagellin; Provisional; Region: PRK12804 508765002348 Bacterial flagellin N-terminal helical region; Region: Flagellin_N; pfam00669 508765002349 Bacterial flagellin C-terminal helical region; Region: Flagellin_C; pfam00700 508765002350 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2604 508765002351 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2604 508765002352 carbamoyl phosphate synthase-like protein; Provisional; Region: PRK12767 508765002353 ATP-grasp domain; Region: ATP-grasp_4; cl17255 508765002354 HAD superfamily (subfamily IA) hydrolase, TIGR02253; Region: CTE7 508765002355 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 508765002356 motif II; other site 508765002357 C-methyltransferase C-terminal domain; Region: Methyltransf_14; pfam08484 508765002358 Methyltransferase domain; Region: Methyltransf_24; pfam13578 508765002359 SpsF is a glycosyltrnasferase implicated in the synthesis of the spore coat; Region: GT2_SpsF; cd02518 508765002360 ligand binding site; other site 508765002361 Sulfatase; Region: Sulfatase; cl17466 508765002362 Serine-pyruvate aminotransferase/archaeal aspartate aminotransferase [Amino acid transport and metabolism]; Region: COG0075 508765002363 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 508765002364 catalytic residue [active] 508765002365 Nucleoside-diphosphate-sugar pyrophosphorylase involved in lipopolysaccharide biosynthesis/translation initiation factor 2B, gamma/epsilon subunits (eIF-2Bgamma/eIF-2Bepsilon) [Cell envelope biogenesis, outer membrane / Translation, ribosomal structure...; Region: GCD1; COG1208 508765002366 Phosphocholine cytidylyltransferases catalyze the synthesis of CDP-choline; Region: PC_cytidylyltransferase; cd02523 508765002367 active site 508765002368 metal-binding site 508765002369 pseudaminic acid biosynthesis-associated protein PseG; Region: PseG; TIGR03590 508765002370 Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013 508765002371 pseudaminic acid synthase; Region: PseI; TIGR03586 508765002372 NeuB family; Region: NeuB; pfam03102 508765002373 C-terminal SAF domain of sialic acid synthetase; Region: SAF_NeuB_like; cd11615 508765002374 NeuB binding interface [polypeptide binding]; other site 508765002375 putative substrate binding site [chemical binding]; other site 508765002376 Polysaccharide biosynthesis protein; Region: Polysacc_synt_2; pfam02719 508765002377 UDP-Glcnac (UDP-linked N-acetylglucosamine) inverting 4,6-dehydratase, extended (e) SDRs; Region: UDP_invert_4-6DH_SDR_e; cd05237 508765002378 NAD(P) binding site [chemical binding]; other site 508765002379 homodimer interface [polypeptide binding]; other site 508765002380 substrate binding site [chemical binding]; other site 508765002381 active site 508765002382 Nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: WcaG; COG0451 508765002383 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 508765002384 NAD(P) binding site [chemical binding]; other site 508765002385 active site 508765002386 flagellin; Provisional; Region: PRK12804 508765002387 Bacterial flagellin N-terminal helical region; Region: Flagellin_N; pfam00669 508765002388 Bacterial flagellin C-terminal helical region; Region: Flagellin_C; pfam00700 508765002389 flagellar basal body rod protein FlgB; Provisional; Region: flgB; PRK12623 508765002390 flagellar basal body rod protein FlgC; Provisional; Region: flgC; PRK12630 508765002391 Flagellar basal body rod FlgEFG protein C-terminal; Region: Flg_bbr_C; pfam06429 508765002392 Flagellar hook-basal body complex protein FliE; Region: FliE; cl09139 508765002393 flagellar MS-ring protein; Reviewed; Region: fliF; PRK06007 508765002394 Secretory protein of YscJ/FliF family; Region: YscJ_FliF; cl01907 508765002395 Flagellar M-ring protein C-terminal; Region: YscJ_FliF_C; pfam08345 508765002396 flagellar motor switch protein G; Validated; Region: fliG; PRK05686 508765002397 FliG C-terminal domain; Region: FliG_C; pfam01706 508765002398 flagellar assembly protein FliH; Region: FliH_bacil; TIGR03825 508765002399 flagellar protein export ATPase FliI; Region: FliI_clade2; TIGR03497 508765002400 ATP synthase alpha/beta family, beta-barrel domain; Region: ATP-synt_ab_N; pfam02874 508765002401 Flagellum-specific ATPase/type III secretory pathway virulence-related protein. This group of ATPases are responsible for the export of flagellum and virulence-related proteins. The bacterial flagellar motor is similar to the F0F1-ATPase, in that they...; Region: ATPase_flagellum-secretory_path_III; cd01136 508765002402 Walker A motif/ATP binding site; other site 508765002403 Walker B motif; other site 508765002404 flagellar export protein FliJ; Region: flagell_FliJ; TIGR02473 508765002405 Flagellar hook-length control protein FliK; Region: Flg_hook; pfam02120 508765002406 Flagellar hook capping protein - N-terminal region; Region: FlgD; pfam03963 508765002407 Protein of unknown function (DUF3766); Region: DUF3766; cl11797 508765002408 flagellar basal body rod protein FlgG; Provisional; Region: flgG; PRK12636 508765002409 Flagella basal body rod protein; Region: Flg_bb_rod; pfam00460 508765002410 Flagellar basal body rod FlgEFG protein C-terminal; Region: Flg_bbr_C; pfam06429 508765002411 flagellar basal body rod protein FlgG; Provisional; Region: flgG; PRK12636 508765002412 Flagella basal body rod protein; Region: Flg_bb_rod; pfam00460 508765002413 Flagellar basal body rod FlgEFG protein C-terminal; Region: Flg_bbr_C; pfam06429 508765002414 Flagellar protein (FlbD); Region: FlbD; pfam06289 508765002415 flagellar motor protein MotP; Reviewed; Region: PRK06926 508765002416 MotA/TolQ/ExbB proton channel family; Region: MotA_ExbB; cl00568 508765002417 flagellar motor protein MotS; Reviewed; Region: PRK06925 508765002418 Membrane MotB of proton-channel complex MotA/MotB; Region: MotB_plug; pfam13677 508765002419 Peptidoglycan binding domains similar to the C-terminal domain of outer-membrane protein OmpA; Region: OmpA_C-like; cd07185 508765002420 ligand binding site [chemical binding]; other site 508765002421 Flagellar basal body-associated protein FliL; Region: FliL; pfam03748 508765002422 Flagellar biosynthesis protein, FliO; Region: FliO; cl01247 508765002423 flagellar biosynthesis protein FliP; Reviewed; Region: fliP; PRK05699 508765002424 Bacterial export proteins, family 3; Region: Bac_export_3; cl00867 508765002425 bifunctional flagellar biosynthesis protein FliR/FlhB; Provisional; Region: PRK12772 508765002426 flagellar biosynthesis protein FliR; Reviewed; Region: fliR; PRK05701 508765002427 Uncharacterized homolog of the cytoplasmic domain of flagellar protein FhlB [Function unknown]; Region: COG2257 508765002428 flagellar biosynthesis protein FlhA; Validated; Region: flhA; PRK06012 508765002429 FHIPEP family; Region: FHIPEP; pfam00771 508765002430 flagellar biosynthesis regulator FlhF; Validated; Region: flhF; PRK05703 508765002431 Circularly permuted YlqF-related GTPases; Region: YlqF_related_GTPase; cl17249 508765002432 GTP/Mg2+ binding site [chemical binding]; other site 508765002433 G5 box; other site 508765002434 The Fer4_NifH superfamily contains a variety of proteins which share a common ATP-binding domain. Functionally, proteins in this superfamily use the energy from hydrolysis of NTP to transfer electron or ion; Region: Fer4_NifH; cl17203 508765002435 G1 box; other site 508765002436 Antiactivator of flagellar biosynthesis FleN, an ATPase [Cell motility]; Region: flhG; COG0455 508765002437 FleN is a member of the Fer4_NifH superfamily. It shares the common function as an ATPase, with the ATP-binding domain at the N-terminus. In Pseudomonas aeruginosa, FleN gene is involved in regulating the number of flagella and chemotactic motility by...; Region: FleN-like; cd02038 508765002438 P-loop; other site 508765002439 Flagellar protein YcgR; Region: YcgR_2; pfam12945 508765002440 c-di-GMP-binding protein [Signal transduction mechanisms]; Region: COG5581 508765002441 PilZ domain; Region: PilZ; pfam07238 508765002442 RNA polymerase sigma factor, FliA/WhiG family; Region: FliA_WhiG; TIGR02479 508765002443 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 508765002444 Sigma-70 region 3; Region: Sigma70_r3; pfam04539 508765002445 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 508765002446 DNA binding residues [nucleotide binding] 508765002447 flagellar basal body rod protein FlgG; Reviewed; Region: flgG; PRK12818 508765002448 Flagellar basal body rod FlgEFG protein C-terminal; Region: Flg_bbr_C; pfam06429 508765002449 flagellar basal body rod protein FlgG; Reviewed; Region: flgG; PRK12817 508765002450 flagellar basal-body rod protein FlgF; Region: flgF; TIGR02490 508765002451 putative manganese-dependent inorganic pyrophosphatase; Provisional; Region: PRK14869 508765002452 The CBS domain, named after human CBS, is a small domain originally identified in cystathionine beta-synthase and is subsequently found in a wide range of different proteins. CBS domains usually occur in tandem repeats. They associate to form a so-called...; Region: CBS_pair; cl15354 508765002453 DRTGG domain; Region: DRTGG; pfam07085 508765002454 The CBS domain, named after human CBS, is a small domain originally identified in cystathionine beta-synthase and is subsequently found in a wide range of different proteins. CBS domains usually occur in tandem repeats. They associate to form a so-called...; Region: CBS_pair; cd02205 508765002455 DHHA2 domain; Region: DHHA2; pfam02833 508765002456 Cation transporter/ATPase, N-terminus; Region: Cation_ATPase_N; pfam00690 508765002457 Cation transport ATPase [Inorganic ion transport and metabolism]; Region: MgtA; COG0474 508765002458 E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122 508765002459 Putative hydrolase of sodium-potassium ATPase alpha subunit; Region: Hydrolase_like2; pfam13246 508765002460 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 508765002461 motif II; other site 508765002462 Cation transporting ATPase, C-terminus; Region: Cation_ATPase_C; pfam00689 508765002463 clostridium toxin-associated regulator BotR; Region: P21_Cbot; TIGR03209 508765002464 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 508765002465 DNA binding residues [nucleotide binding] 508765002466 Protein of unknown function (DUF2762); Region: DUF2762; pfam10960 508765002467 Protein of unknown function (DUF4003); Region: DUF4003; pfam13170 508765002468 This group contains class II terpene cyclases, protein prenyltransferases beta subunit, two broadly specific proteinase inhibitors alpha2-macroglobulin (alpha (2)-M) and pregnancy zone protein (PZP) and, the C3 C4 and C5 components of vertebrate...; Region: ISOPREN_C2_like; cl08267 508765002469 Predicted ATP-dependent protease [Posttranslational modification, protein turnover, chaperones]; Region: LonB; COG1067 508765002470 Lon protease (S16) C-terminal proteolytic domain; Region: Lon_C; pfam05362 508765002471 Sulphate Transporter and Anti-Sigma factor antagonist) domain of anti-anti-sigma factors, key regulators of anti-sigma factors by phosphorylation; Region: STAS_anti-anti-sigma_factors; cd07043 508765002472 anti sigma factor interaction site; other site 508765002473 regulatory phosphorylation site [posttranslational modification]; other site 508765002474 Anti-sigma regulatory factor (Ser/Thr protein kinase) [Signal transduction mechanisms]; Region: RsbW; COG2172 508765002475 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 508765002476 ATP binding site [chemical binding]; other site 508765002477 Mg2+ binding site [ion binding]; other site 508765002478 G-X-G motif; other site 508765002479 sporulation sigma factor SigF; Validated; Region: PRK05572 508765002480 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 508765002481 Sigma-70 region 3; Region: Sigma70_r3; pfam04539 508765002482 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 508765002483 DNA binding residues [nucleotide binding] 508765002484 stage V sporulation protein AC; Region: spore_V_AC; TIGR02838 508765002485 stage V sporulation protein AD; Validated; Region: PRK08304 508765002486 stage V sporulation protein AD; Provisional; Region: PRK12404 508765002487 SpoVA protein; Region: SpoVA; cl04298 508765002488 Cation transport ATPase [Inorganic ion transport and metabolism]; Region: MgtA; COG0474 508765002489 Cation transporter/ATPase, N-terminus; Region: Cation_ATPase_N; smart00831 508765002490 E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122 508765002491 Putative hydrolase of sodium-potassium ATPase alpha subunit; Region: Hydrolase_like2; pfam13246 508765002492 Competence protein; Region: Competence; pfam03772 508765002493 DNA polymerase III subunit delta; Reviewed; Region: holA; PRK05574 508765002494 DNA polymerase III, delta subunit; Region: DNA_pol3_delta; pfam06144 508765002495 30S ribosomal protein S20; Reviewed; Region: rpsT; PRK00239 508765002496 germination protease; Provisional; Region: PRK12362 508765002497 Stage II sporulation protein P (SpoIIP); Region: SpoIIP; pfam07454 508765002498 stage II sporulation protein P; Region: spore_II_P; TIGR02867 508765002499 GTP-binding protein LepA; Provisional; Region: PRK05433 508765002500 LepA also known as Elongation Factor 4 (EF4); Region: LepA; cd01890 508765002501 G1 box; other site 508765002502 putative GEF interaction site [polypeptide binding]; other site 508765002503 GTP/Mg2+ binding site [chemical binding]; other site 508765002504 Switch I region; other site 508765002505 G2 box; other site 508765002506 G3 box; other site 508765002507 Switch II region; other site 508765002508 G4 box; other site 508765002509 G5 box; other site 508765002510 lepA_II: This subfamily represents the domain II of LepA, a GTP-binding protein localized in the cytoplasmic membrane. The N-terminal domain of LepA shares regions of homology to translation factors. In terms of interaction with the ribosome, EF-G, EF-Tu...; Region: lepA_II; cd03699 508765002511 lepA_C: This family represents the C-terminal region of LepA, a GTP-binding protein localized in the cytoplasmic membrane. LepA is ubiquitous in Bacteria and Eukaryota (e.g. Saccharomyces cerevisiae GUF1p), but is missing from Archaea. LepA exhibits...; Region: lepA_C; cd03709 508765002512 GTP-binding protein LepA C-terminus; Region: LepA_C; pfam06421 508765002513 coproporphyrinogen III oxidase; Provisional; Region: PRK05799 508765002514 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 508765002515 FeS/SAM binding site; other site 508765002516 HemN C-terminal domain; Region: HemN_C; pfam06969 508765002517 heat-inducible transcription repressor; Provisional; Region: hrcA; PRK00082 508765002518 Winged helix-turn-helix transcription repressor, HrcA DNA-binding; Region: HrcA_DNA-bdg; pfam03444 508765002519 GrpE; Region: GrpE; pfam01025 508765002520 GrpE is the adenine nucleotide exchange factor of DnaK (Hsp70)-type ATPases. The GrpE dimer binds to the ATPase domain of Hsp70 catalyzing the dissociation of ADP, which enables rebinding of ATP, one step in the Hsp70 reaction cycle in protein folding; Region: GrpE; cd00446 508765002521 dimer interface [polypeptide binding]; other site 508765002522 hsp70 (ATPase domain) interactions [polypeptide binding]; other site 508765002523 molecular chaperone DnaK; Provisional; Region: dnaK; PRK00290 508765002524 Nucleotide-binding domain of human HSPA9 and similar proteins; Region: HSPA9-Ssq1-like_NBD; cd10234 508765002525 nucleotide binding site [chemical binding]; other site 508765002526 NEF interaction site [polypeptide binding]; other site 508765002527 SBD interface [polypeptide binding]; other site 508765002528 chaperone protein DnaJ; Provisional; Region: PRK14297 508765002529 DnaJ domain or J-domain. DnaJ/Hsp40 (heat shock protein 40) proteins are highly conserved and play crucial roles in protein translation, folding, unfolding, translocation, and degradation. They act primarily by stimulating the ATPase activity of Hsp70s; Region: DnaJ; cd06257 508765002530 HSP70 interaction site [polypeptide binding]; other site 508765002531 C-terminal substrate binding domain of DnaJ and HSP40; Region: DnaJ_C; cd10747 508765002532 substrate binding site [polypeptide binding]; other site 508765002533 dimer interface [polypeptide binding]; other site 508765002534 Sulfite reductase, beta subunit (hemoprotein) [Inorganic ion transport and metabolism]; Region: CysI; COG0155 508765002535 Nitrite/Sulfite reductase ferredoxin-like half domain; Region: NIR_SIR_ferr; pfam03460 508765002536 tRNA (guanine-N(7)-)-methyltransferase; Reviewed; Region: trmB; PRK00121 508765002537 Ribosomal protein L11 methyltransferase (PrmA); Region: PrmA; pfam06325 508765002538 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 508765002539 S-adenosylmethionine binding site [chemical binding]; other site 508765002540 16S ribosomal RNA methyltransferase RsmE; Provisional; Region: PRK11713 508765002541 RNA methyltransferase, RsmE family; Region: TIGR00046 508765002542 2-methylthioadenine synthetase [Translation, ribosomal structure and biogenesis]; Region: MiaB; COG0621 508765002543 Uncharacterized protein family UPF0004; Region: UPF0004; pfam00919 508765002544 Protein Kinase C Interacting protein related (PKCI): PKCI and related proteins belong to the ubiquitous HIT family of hydrolases that act on alpha-phosphates of ribonucleotides. The members of this subgroup have a conserved HxHxHxx motif (x is a...; Region: PKCI_related; cd01276 508765002545 nucleotide binding site/active site [active] 508765002546 HIT family signature motif; other site 508765002547 catalytic residue [active] 508765002548 30S ribosomal protein S21; Reviewed; Region: rpsU; PRK00270 508765002549 Yqey-like protein; Region: YqeY; pfam09424 508765002550 YabP family; Region: YabP; cl06766 508765002551 sporulation protein YqfD; Region: spore_yqfD; TIGR02876 508765002552 Putative stage IV sporulation protein YqfD; Region: YqfD; pfam06898 508765002553 Predicted membrane-associated HD superfamily hydrolase [General function prediction only]; Region: COG1480 508765002554 7TM receptor with intracellular HD hydrolase; Region: 7TM-7TMR_HD; pfam07698 508765002555 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 508765002556 Zn2+ binding site [ion binding]; other site 508765002557 Mg2+ binding site [ion binding]; other site 508765002558 metal-binding heat shock protein; Provisional; Region: PRK00016 508765002559 Diacylglycerol kinase [Cell envelope biogenesis, outer membrane]; Region: DgkA; COG0818 508765002560 PAP2_like proteins, diacylglycerol_kinase like sub-family. In some prokaryotes, PAP2_like phosphatase domains appear fused to E. coli DAGK-like trans-membrane diacylglycerol kinase domains. The cellular function of these architectures remains to be...; Region: PAP2_diacylglycerolkinase; cd03383 508765002561 Membrane-associated phospholipid phosphatase [Lipid metabolism]; Region: PgpB; COG0671 508765002562 active site 508765002563 GTPase Era; Reviewed; Region: era; PRK00089 508765002564 E. coli Ras-like protein (Era) is a multifunctional GTPase; Region: Era; cd04163 508765002565 G1 box; other site 508765002566 GTP/Mg2+ binding site [chemical binding]; other site 508765002567 Switch I region; other site 508765002568 G2 box; other site 508765002569 Switch II region; other site 508765002570 G3 box; other site 508765002571 G4 box; other site 508765002572 G5 box; other site 508765002573 KH domain; Region: KH_2; pfam07650 508765002574 Recombination protein O N terminal; Region: RecO_N; pfam11967 508765002575 DNA repair protein RecO; Reviewed; Region: recO; PRK00085 508765002576 Recombination protein O C terminal; Region: RecO_C; pfam02565 508765002577 Domain of unknown function (DUF4342); Region: DUF4342; pfam14242 508765002578 HTH domain; Region: HTH_11; pfam08279 508765002579 The CBS domain, named after human CBS, is a small domain originally identified in cystathionine beta-synthase and is subsequently found in a wide range of different proteins. CBS domains usually occur in tandem repeats. They associate to form a so-called...; Region: CBS_pair_4; cd04617 508765002580 FOG: CBS domain [General function prediction only]; Region: COG0517 508765002581 pyruvate phosphate dikinase; Provisional; Region: PRK09279 508765002582 Pyruvate phosphate dikinase, PEP/pyruvate binding domain; Region: PPDK_N; pfam01326 508765002583 PEP-utilising enzyme, mobile domain; Region: PEP-utilizers; pfam00391 508765002584 PEP-utilising enzyme, TIM barrel domain; Region: PEP-utilizers_C; pfam02896 508765002585 spore coat protein, CotS family; Region: spore_CotS; TIGR02906 508765002586 Ecdysteroid kinase; Region: EcKinase; cl17738 508765002587 spore coat protein YutH; Region: spore_yutH; TIGR02905 508765002588 deoxyguanosinetriphosphate triphosphohydrolase-like protein; Provisional; Region: PRK01286 508765002589 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 508765002590 Zn2+ binding site [ion binding]; other site 508765002591 Mg2+ binding site [ion binding]; other site 508765002592 Phosphohydrolase-associated domain; Region: HD_assoc; pfam13286 508765002593 DNA primase; Validated; Region: dnaG; PRK05667 508765002594 CHC2 zinc finger; Region: zf-CHC2; pfam01807 508765002595 DNA primase catalytic core, N-terminal domain; Region: Toprim_N; pfam08275 508765002596 TOPRIM_DnaG_primases: The topoisomerase-primase (TORPIM) nucleotidyl transferase/hydrolase domain found in the active site regions of proteins similar to Escherichia coli DnaG. Primases synthesize RNA primers for the initiation of DNA replication. DnaG...; Region: TOPRIM_DnaG_primases; cd03364 508765002597 active site 508765002598 metal binding site [ion binding]; metal-binding site 508765002599 interdomain interaction site; other site 508765002600 DnaB-helicase binding domain of primase; Region: DnaB_bind; pfam10410 508765002601 DnaB-like helicase N terminal domain; Region: DnaB; pfam00772 508765002602 RNA polymerase sigma factor RpoD; Validated; Region: PRK09210 508765002603 Sigma-70 factor, region 1.1; Region: Sigma70_r1_1; pfam03979 508765002604 Sigma-70 factor, region 1.2; Region: Sigma70_r1_2; pfam00140 508765002605 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 508765002606 Sigma-70 region 3; Region: Sigma70_r3; pfam04539 508765002607 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 508765002608 DNA binding residues [nucleotide binding] 508765002609 Family of unknown function (DUF633); Region: DUF633; pfam04816 508765002610 Uncharacterized conserved protein [Function unknown]; Region: COG0327 508765002611 NIF3 (NGG1p interacting factor 3); Region: NIF3; pfam01784 508765002612 tyrosine recombinase XerD; Region: recomb_XerD; TIGR02225 508765002613 phiLC3 phage and phage-related integrases, site-specific recombinases, DNA breaking-rejoining enzymes, C-terminal catalytic domain. This CD includes various bacterial (mainly gram positive) and phage integrases, including those similar to Lactococcus...; Region: INT_phiLC3_C; cd01189 508765002614 Int/Topo IB signature motif; other site 508765002615 Domain of unknown function (DUF955); Region: DUF955; pfam06114 508765002616 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 508765002617 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 508765002618 non-specific DNA binding site [nucleotide binding]; other site 508765002619 salt bridge; other site 508765002620 sequence-specific DNA binding site [nucleotide binding]; other site 508765002621 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 508765002622 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 508765002623 non-specific DNA binding site [nucleotide binding]; other site 508765002624 salt bridge; other site 508765002625 sequence-specific DNA binding site [nucleotide binding]; other site 508765002626 ORF6N domain; Region: ORF6N; pfam10543 508765002627 Helix-turn-helix domain; Region: HTH_17; pfam12728 508765002628 AntA/AntB antirepressor; Region: AntA; pfam08346 508765002629 ORF6C domain; Region: ORF6C; pfam10552 508765002630 DnaB-like helicase N terminal domain; Region: DnaB; pfam00772 508765002631 replicative DNA helicase; Region: DnaB; TIGR00665 508765002632 DnaB helicase C terminal domain. The hexameric helicase DnaB unwinds the DNA duplex at the chromosome replication fork. Although the mechanism by which DnaB both couples ATP hydrolysis to translocation along DNA and denatures the duplex is unknown, a...; Region: DnaB_C; cd00984 508765002633 Walker A motif; other site 508765002634 ATP binding site [chemical binding]; other site 508765002635 Walker B motif; other site 508765002636 DNA binding loops [nucleotide binding] 508765002637 Cytosine-C5 specific DNA methylases; Methyl transfer reactions play an important role in many aspects of biology. Cytosine-specific DNA methylases are found both in prokaryotes and eukaryotes. DNA methylation, or the covalent addition of a methyl group...; Region: Cyt_C5_DNA_methylase; cd00315 508765002638 cofactor binding site; other site 508765002639 DNA binding site [nucleotide binding] 508765002640 substrate interaction site [chemical binding]; other site 508765002641 Nucleoside Triphosphate Pyrophosphohydrolase (EC 3.6.1.8) MazG-like domain found in uncharacterized protein from Archaeoglobus fulgidus (Af0060) and its bacterial homologs; Region: NTP-PPase_Af0060_like; cd11533 508765002642 homodimer interface [polypeptide binding]; other site 508765002643 metal binding site [ion binding]; metal-binding site 508765002644 DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213 508765002645 active site 508765002646 DNA binding site [nucleotide binding] 508765002647 Int/Topo IB signature motif; other site 508765002648 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cl17315 508765002649 DNA binding residues [nucleotide binding] 508765002650 Phage terminase, small subunit; Region: Terminase_4; pfam05119 508765002651 Phage Terminase; Region: Terminase_1; pfam03354 508765002652 phage portal protein, HK97 family; Region: portal_HK97; TIGR01537 508765002653 Phage-related protein [Function unknown]; Region: COG4695; cl01923 508765002654 Caudovirus prohead protease; Region: Peptidase_U35; pfam04586 508765002655 phage major capsid protein, HK97 family; Region: major_cap_HK97; TIGR01554 508765002656 Phage capsid family; Region: Phage_capsid; pfam05065 508765002657 Head-Tail Connector Protein gp6 of Bacteriophage HK97 and similar proteins; Region: gp6; cd08054 508765002658 oligomerization interface [polypeptide binding]; other site 508765002659 Phage head-tail joining protein; Region: Phage_H_T_join; cl11461 508765002660 Bacteriophage protein of unknown function (DUF646); Region: DUF646; cl12124 508765002661 phage major tail protein, phi13 family; Region: maj_tail_phi13; TIGR01603 508765002662 phage tail tape measure protein, TP901 family, core region; Region: tape_meas_TP901; TIGR01760 508765002663 Phage-related protein [Function unknown]; Region: COG5412 508765002664 Phage-related protein [Function unknown]; Region: COG4722 508765002665 Phage tail protein; Region: Sipho_tail; cl17486 508765002666 Prophage endopeptidase tail; Region: Prophage_tail; cl12123 508765002667 Reovirus sigma C capsid protein; Region: Reo_sigmaC; pfam04582 508765002668 Haemolysin XhlA; Region: XhlA; pfam10779 508765002669 Lyc muramidase is an autolytic lysozyme (autolysin) from Clostridium acetobutylicum encoded by the lyc gene. Lyc has a glycosyl hydrolase family 25 (GH25) catalytic domain. Endo-N-acetylmuramidases are lysozymes (also referred to as peptidoglycan...; Region: GH25_Lyc-like; cd06525 508765002670 Glycosyl hydrolases family 25; Region: Glyco_hydro_25; pfam01183 508765002671 active site 508765002672 Protein of unknown function (DUF2762); Region: DUF2762; pfam10960 508765002673 Acetyltransferases, including N-acetylases of ribosomal proteins [Translation, ribosomal structure and biogenesis]; Region: RimL; COG1670 508765002674 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl17182 508765002675 Exopolysaccharide biosynthesis protein related to N-acetylglucosamine-1-phosphodiester alpha-N-acetylglucosaminidase [Carbohydrate transport and metabolism]; Region: EpsL; COG4632 508765002676 glycerol-3-phosphate transporter ATP-binding subunit; Provisional; Region: ugpC; PRK11650 508765002677 The N-terminal ATPase domain of the maltose transporter, MalK; Region: ABC_MalK_N; cd03301 508765002678 Walker A/P-loop; other site 508765002679 ATP binding site [chemical binding]; other site 508765002680 Q-loop/lid; other site 508765002681 ABC transporter signature motif; other site 508765002682 Walker B; other site 508765002683 D-loop; other site 508765002684 H-loop/switch region; other site 508765002685 TOBE domain; Region: TOBE_2; pfam08402 508765002686 PucR C-terminal helix-turn-helix domain; Region: HTH_30; pfam13556 508765002687 Transcriptional regulators [Transcription]; Region: PurR; COG1609 508765002688 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 508765002689 DNA binding site [nucleotide binding] 508765002690 domain linker motif; other site 508765002691 Ligand binding domain of the LacI tanscriptional regulator family belonging to the type I periplasmic-binding fold protein superfamily; Region: PBP1_LacI_sugar_binding_like; cd06267 508765002692 dimerization interface [polypeptide binding]; other site 508765002693 ligand binding site [chemical binding]; other site 508765002694 4-alpha-glucanotransferase; Provisional; Region: PRK14508 508765002695 This is a family of oligosaccharide phosphorylases. It includes yeast and mammalian glycogen phosphorylases, plant starch/glucan phosphorylase, as well as the maltodextrin phosphorylases of bacteria. The members of this family catalyze the breakdown of...; Region: GT1_Glycogen_Phosphorylase; cd04300 508765002696 homodimer interface [polypeptide binding]; other site 508765002697 glycogen/starch/alpha-glucan phosphorylases; Region: P_ylase; TIGR02093 508765002698 active site pocket [active] 508765002699 potassium-transporting ATPase subunit A; Provisional; Region: PRK05482 508765002700 potassium-transporting ATPase subunit B; Provisional; Region: PRK01122 508765002701 E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122 508765002702 potassium-transporting ATPase subunit C; Provisional; Region: PRK13996 508765002703 Osmosensitive K+ channel histidine kinase [Signal transduction mechanisms]; Region: KdpD; COG2205 508765002704 Osmosensitive K+ channel His kinase sensor domain; Region: KdpD; pfam02702 508765002705 USP domain is located between the N-terminal sensor domain and C-terminal catalytic domain of this Osmosensitive K+ channel histidine kinase family. The family of KdpD sensor kinase proteins regulates the kdpFABC operon responsible for potassium...; Region: USP_OKCHK; cd01987 508765002706 Ligand Binding Site [chemical binding]; other site 508765002707 Domain of unknown function (DUF4118); Region: DUF4118; pfam13493 508765002708 GAF domain; Region: GAF_3; pfam13492 508765002709 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 508765002710 dimer interface [polypeptide binding]; other site 508765002711 phosphorylation site [posttranslational modification] 508765002712 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 508765002713 ATP binding site [chemical binding]; other site 508765002714 G-X-G motif; other site 508765002715 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 508765002716 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 508765002717 active site 508765002718 phosphorylation site [posttranslational modification] 508765002719 intermolecular recognition site; other site 508765002720 dimerization interface [polypeptide binding]; other site 508765002721 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 508765002722 DNA binding site [nucleotide binding] 508765002723 Methyltransferase domain; Region: Methyltransf_31; pfam13847 508765002724 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 508765002725 S-adenosylmethionine binding site [chemical binding]; other site 508765002726 Putative D-isomer specific 2-hydroxyacid dehydrogenases; Region: 2-Hacid_dh_4; cd12162 508765002727 2-hydroxyacid dehydrogenase; Provisional; Region: PRK08410 508765002728 putative ligand binding site [chemical binding]; other site 508765002729 putative NAD binding site [chemical binding]; other site 508765002730 catalytic site [active] 508765002731 Predicted hydrolases of the HAD superfamily [General function prediction only]; Region: Cof; COG0561 508765002732 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 508765002733 active site 508765002734 motif I; other site 508765002735 motif II; other site 508765002736 haloacid dehalogenase-like hydrolase; Region: HAD; cl17202 508765002737 Predicted hydrolases of the HAD superfamily [General function prediction only]; Region: Cof; COG0561 508765002738 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 508765002739 active site 508765002740 motif I; other site 508765002741 motif II; other site 508765002742 haloacid dehalogenase-like hydrolase; Region: HAD; cl17202 508765002743 putative hydrolase; Validated; Region: PRK09248 508765002744 Polymerase and Histidinol Phosphatase domain of Ycdx like; Region: PHP_HisPPase_Ycdx_like; cd07437 508765002745 active site 508765002746 ribosomal-protein-alanine acetyltransferase; Region: rimI; TIGR01575 508765002747 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 508765002748 Coenzyme A binding pocket [chemical binding]; other site 508765002749 Nucleoside diphosphate kinase Group I (NDPk_I)-like: NDP kinase domains are present in a large family of structurally and functionally conserved proteins from bacteria to humans that generally catalyze the transfer of gamma-phosphates of a nucleoside...; Region: NDPk_I; cd04413 508765002750 active site 508765002751 multimer interface [polypeptide binding]; other site 508765002752 Spermidine/putrescine-binding periplasmic protein [Amino acid transport and metabolism]; Region: PotD; COG0687 508765002753 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; cl17199 508765002754 ABC-type spermidine/putrescine transport system, permease component II [Amino acid transport and metabolism]; Region: PotC; COG1177 508765002755 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 508765002756 dimer interface [polypeptide binding]; other site 508765002757 conserved gate region; other site 508765002758 putative PBP binding loops; other site 508765002759 ABC-ATPase subunit interface; other site 508765002760 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 508765002761 dimer interface [polypeptide binding]; other site 508765002762 conserved gate region; other site 508765002763 putative PBP binding loops; other site 508765002764 ABC-ATPase subunit interface; other site 508765002765 ABC-type spermidine/putrescine transport systems, ATPase components [Amino acid transport and metabolism]; Region: PotA; COG3842 508765002766 ATP-binding cassette domain of the polyamine transporter; Region: ABC_PotA_N; cd03300 508765002767 Walker A/P-loop; other site 508765002768 ATP binding site [chemical binding]; other site 508765002769 Q-loop/lid; other site 508765002770 ABC transporter signature motif; other site 508765002771 Walker B; other site 508765002772 D-loop; other site 508765002773 H-loop/switch region; other site 508765002774 TOBE domain; Region: TOBE_2; pfam08402 508765002775 DNA-binding transcriptional repressor PuuR; Provisional; Region: PRK09943 508765002776 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 508765002777 non-specific DNA binding site [nucleotide binding]; other site 508765002778 salt bridge; other site 508765002779 sequence-specific DNA binding site [nucleotide binding]; other site 508765002780 Cupin domain; Region: Cupin_2; pfam07883 508765002781 Acetyltransferase (GNAT) domain; Region: Acetyltransf_3; pfam13302 508765002782 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 508765002783 Coenzyme A binding pocket [chemical binding]; other site 508765002784 Putative amidotransferase; Region: DUF4066; pfam13278 508765002785 Na+/alanine symporter [Amino acid transport and metabolism]; Region: AlsT; COG1115 508765002786 amino acid carrier protein; Region: agcS; TIGR00835 508765002787 Transglycosylase; Region: Transgly; pfam00912 508765002788 penicillin-binding protein, 1A family; Region: PBP_1a_fam; TIGR02074 508765002789 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; cl17760 508765002790 Sporulation protein YunB (Spo_YunB); Region: Spore_YunB; cl09783 508765002791 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 508765002792 active site 508765002793 GTP-binding protein HflX; Region: GTP_HflX; TIGR03156 508765002794 GTP-binding GTPase N-terminal; Region: GTP-bdg_N; pfam13167 508765002795 HflX GTPase family; Region: HflX; cd01878 508765002796 G1 box; other site 508765002797 GTP/Mg2+ binding site [chemical binding]; other site 508765002798 Switch I region; other site 508765002799 G2 box; other site 508765002800 G3 box; other site 508765002801 Switch II region; other site 508765002802 G4 box; other site 508765002803 G5 box; other site 508765002804 Nucleotidyltransferase (NT) domain of Staphylococcus aureus kanamycin nucleotidyltransferase, and similar proteins; Region: NT_KNTase_like; cd05403 508765002805 active site 508765002806 NTP binding site [chemical binding]; other site 508765002807 metal binding triad [ion binding]; metal-binding site 508765002808 antibiotic binding site [chemical binding]; other site 508765002809 Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain (MocR family) and their eukaryotic orthologs [Transcription / Amino acid transport and metabolism]; Region: ARO8; COG1167 508765002810 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 508765002811 DNA-binding site [nucleotide binding]; DNA binding site 508765002812 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 508765002813 pyridoxal 5'-phosphate binding site [chemical binding]; other site 508765002814 homodimer interface [polypeptide binding]; other site 508765002815 catalytic residue [active] 508765002816 Uncharacterized conserved protein [Function unknown]; Region: COG1739 508765002817 Uncharacterized protein family UPF0029; Region: UPF0029; pfam01205 508765002818 Domain of unknown function (DUF1949); Region: DUF1949; pfam09186 508765002819 hypothetical protein; Validated; Region: PRK00110 508765002820 S-adenosylmethionine decarboxylase; Provisional; Region: PRK05462 508765002821 Arginine/lysine/ornithine decarboxylases [Amino acid transport and metabolism]; Region: LdcC; COG1982 508765002822 Ornithine decarboxylase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD corresponds to ornithine decarboxylase (ODC), arginine decarboxylase (ADC) and lysine...; Region: Orn_deC_like; cd00615 508765002823 homodimer interface [polypeptide binding]; other site 508765002824 pyridoxal 5'-phosphate binding site [chemical binding]; other site 508765002825 catalytic residue [active] 508765002826 Orn/Lys/Arg decarboxylase, C-terminal domain; Region: OKR_DC_1_C; pfam03711 508765002827 spermidine synthase; Provisional; Region: PRK00811 508765002828 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 508765002829 S-adenosylmethionine binding site [chemical binding]; other site 508765002830 Saccharopine dehydrogenase and related proteins [Amino acid transport and metabolism]; Region: LYS9; COG1748 508765002831 NAD(P) binding domain of Shikimate dehydrogenase; Region: NAD_bind_Shikimate_DH; cd01065 508765002832 carboxynorspermidine decarboxylase; Region: nspC; TIGR01047 508765002833 Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzyme Carboxynorspermidine Decarboxylase; Region: PLPDE_III_CANSDC; cd06829 508765002834 dimer interface [polypeptide binding]; other site 508765002835 active site 508765002836 pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site 508765002837 catalytic residues [active] 508765002838 substrate binding site [chemical binding]; other site 508765002839 PAS domain; Region: PAS; smart00091 508765002840 PAS fold; Region: PAS_4; pfam08448 508765002841 GAF domain; Region: GAF; pfam01590 508765002842 PAS domain S-box; Region: sensory_box; TIGR00229 508765002843 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 508765002844 putative active site [active] 508765002845 heme pocket [chemical binding]; other site 508765002846 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 508765002847 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 508765002848 dimer interface [polypeptide binding]; other site 508765002849 phosphorylation site [posttranslational modification] 508765002850 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 508765002851 ATP binding site [chemical binding]; other site 508765002852 Mg2+ binding site [ion binding]; other site 508765002853 G-X-G motif; other site 508765002854 agmatinase; Region: agmatinase; TIGR01230 508765002855 Agmatinase and related proteins; Region: Agmatinase-like_2; cd11593 508765002856 putative active site [active] 508765002857 Mn binding site [ion binding]; other site 508765002858 Glycerol dehydrogenase and related enzymes [Energy production and conversion]; Region: GldA; COG0371 508765002859 Glycerol dehydrogenases (GlyDH) catalyzes oxidation of glycerol to dihydroxyacetone in glycerol dissmilation; Region: GlyDH; cd08170 508765002860 dimer interface [polypeptide binding]; other site 508765002861 active site 508765002862 metal binding site [ion binding]; metal-binding site 508765002863 Cache domain; Region: Cache_1; pfam02743 508765002864 HAMP domain; Region: HAMP; pfam00672 508765002865 dimerization interface [polypeptide binding]; other site 508765002866 Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer); Region: MA; smart00283 508765002867 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 508765002868 dimer interface [polypeptide binding]; other site 508765002869 putative CheW interface [polypeptide binding]; other site 508765002870 Predicted Fe-S oxidoreductases [General function prediction only]; Region: COG0535 508765002871 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 508765002872 FeS/SAM binding site; other site 508765002873 Domain of unknown function (DUF4008); Region: DUF4008; pfam13186 508765002874 Holliday junction DNA helicase RuvA; Reviewed; Region: ruvA; PRK00116 508765002875 RuvA N terminal domain; Region: RuvA_N; pfam01330 508765002876 RuvA, C-terminal domain; Region: RuvA_C; pfam07499 508765002877 Holliday junction DNA helicase RuvB; Reviewed; Region: ruvB; PRK00080 508765002878 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 508765002879 Walker A motif; other site 508765002880 ATP binding site [chemical binding]; other site 508765002881 Walker B motif; other site 508765002882 arginine finger; other site 508765002883 Holliday junction DNA helicase ruvB C-terminus; Region: RuvB_C; pfam05491 508765002884 S-adenosylmethionine:tRNA ribosyltransferase-isomerase; Provisional; Region: queA; PRK00147 508765002885 S-adenosylmethionine:tRNA ribosyltransferase-isomerase; Region: queA; TIGR00113 508765002886 queuine tRNA-ribosyltransferase; Provisional; Region: tgt; PRK00112 508765002887 Queuine/archaeosine tRNA-ribosyltransferase [Translation, ribosomal structure and biogenesis]; Region: Tgt; COG0343 508765002888 preprotein translocase subunit YajC; Validated; Region: yajC; PRK05585 508765002889 Protein of unknown function (DUF3792); Region: DUF3792; pfam12670 508765002890 bifunctional preprotein translocase subunit SecD/SecF; Reviewed; Region: PRK13024 508765002891 protein-export membrane protein, SecD/SecF family; Region: 2A0604s01; TIGR00916 508765002892 SecD/SecF GG Motif; Region: Sec_GG; pfam07549 508765002893 Protein export membrane protein; Region: SecD_SecF; pfam02355 508765002894 DHH family; Region: DHH; pfam01368 508765002895 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 508765002896 active site 508765002897 Guanosine polyphosphate pyrophosphohydrolases/synthetases [Signal transduction mechanisms / Transcription]; Region: SpoT; COG0317 508765002898 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 508765002899 Zn2+ binding site [ion binding]; other site 508765002900 Mg2+ binding site [ion binding]; other site 508765002901 Nucleotidyltransferase (NT) domain of RelA- and SpoT-like ppGpp synthetases and hydrolases; Region: NT_Rel-Spo_like; cd05399 508765002902 synthetase active site [active] 508765002903 NTP binding site [chemical binding]; other site 508765002904 metal binding site [ion binding]; metal-binding site 508765002905 TGS_RelA_SpoT: The RelA (SpoT) protein, also referred to as ppGpp hydrolase/synthetase, is a ribosome-associated protein that is activated during amino acid starvation and thought to mediate the stringent response. RelA contains a TGS domain, named after...; Region: TGS_RelA_SpoT; cd01668 508765002906 ACT domain found C-terminal of the RelA/SpoT domains; Region: ACT_RelA-SpoT; cd04876 508765002907 D-Tyrosyl-tRNAtyr deacylases; a class of tRNA-dependent hydrolases which are capable of hydrolyzing the ester bond of D-Tyrosyl-tRNA reducing the level of cellular D-Tyrosine while recycling the peptidyl-tRNA; found in bacteria and in eukaryotes but not...; Region: Dtyr_deacylase; cd00563 508765002908 putative active site [active] 508765002909 dimerization interface [polypeptide binding]; other site 508765002910 putative tRNAtyr binding site [nucleotide binding]; other site 508765002911 Zn-dependent hydrolases, including glyoxylases [General function prediction only]; Region: GloB; COG0491 508765002912 Uncharacterized flavoproteins [Energy production and conversion]; Region: FpaA; COG0426 508765002913 coproporphyrinogen III oxidase; Provisional; Region: PRK08207 508765002914 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 508765002915 FeS/SAM binding site; other site 508765002916 histidyl-tRNA synthetase; Reviewed; Region: hisS; PRK00037 508765002917 Class II Histidinyl-tRNA synthetase (HisRS)-like catalytic core domain. HisRS is a homodimer. It is responsible for the attachment of histidine to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for...; Region: HisRS-like_core; cd00773 508765002918 dimer interface [polypeptide binding]; other site 508765002919 motif 1; other site 508765002920 active site 508765002921 motif 2; other site 508765002922 motif 3; other site 508765002923 HisRS Histidyl-anticodon binding domain. HisRS belongs to class II aminoacyl-tRNA synthetases (aaRS). This alignment contains the anticodon binding domain, which is responsible for specificity in tRNA-binding, so that the activated amino acid is...; Region: HisRS_anticodon; cd00859 508765002924 anticodon binding site; other site 508765002925 aspartyl-tRNA synthetase; Validated; Region: aspS; PRK00476 508765002926 EcAspRS_like_N: N-terminal, anticodon recognition domain of the type found in Escherichia coli aspartyl-tRNA synthetase (AspRS), the human mitochondrial (mt) AspRS-2, the discriminating (D) Thermus thermophilus AspRS-1, and the nondiscriminating (ND)...; Region: EcAspRS_like_N; cd04317 508765002927 dimer interface [polypeptide binding]; other site 508765002928 anticodon binding site; other site 508765002929 Asp tRNA synthetase (aspRS) class II core domain. Class II assignment is based upon its structure and the presence of three characteristic sequence motifs. AspRS is a homodimer, which attaches a specific amino acid to the 3' OH group of ribose of...; Region: AspRS_core; cd00777 508765002930 homodimer interface [polypeptide binding]; other site 508765002931 motif 1; other site 508765002932 active site 508765002933 motif 2; other site 508765002934 GAD domain; Region: GAD; pfam02938 508765002935 Class II tRNA amino-acyl synthetase-like catalytic core domain. Class II amino acyl-tRNA synthetases (aaRS) share a common fold and generally attach an amino acid to the 3' OH of ribose of the appropriate tRNA. PheRS is an exception in that it...; Region: class_II_aaRS-like_core; cl00268 508765002936 active site 508765002937 motif 3; other site 508765002938 Protein tyrosine phosphatases (PTP) catalyze the dephosphorylation of phosphotyrosine peptides; they regulate phosphotyrosine levels in signal transduction pathways. The depth of the active site cleft renders the enzyme specific for phosphorylated Tyr; Region: PTPc; cl00053 508765002939 Protein of unknown function (DUF554); Region: DUF554; pfam04474 508765002940 Rhodanese Homology Domain (RHOD); an alpha beta fold domain found duplicated in the rhodanese protein. The cysteine containing enzymatically active version of the domain is also found in the Cdc25 class of protein phosphatases and a variety of proteins...; Region: RHOD; cd00158 508765002941 active site residue [active] 508765002942 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 508765002943 dimerization interface [polypeptide binding]; other site 508765002944 putative DNA binding site [nucleotide binding]; other site 508765002945 putative Zn2+ binding site [ion binding]; other site 508765002946 This uncharacterized conserved protein belongs to a family of iron-molybdenum cluster-binding proteins that includes NifX, NifB, and NifY, all of which are involved in the synthesis of an iron-molybdenum cofactor (FeMo-co) that binds the active site of...; Region: MTH1175; cd00851 508765002947 homoserine dehydrogenase; Provisional; Region: PRK06349 508765002948 Homoserine dehydrogenase, NAD binding domain; Region: NAD_binding_3; pfam03447 508765002949 Homoserine dehydrogenase; Region: Homoserine_dh; pfam00742 508765002950 ACT_HSDH_Hom CD includes the C-terminal ACT domain of the NAD(P)H-dependent, homoserine dehydrogenase (HSDH) and related domains; Region: ACT_HSDH-Hom; cd04881 508765002951 Glycerol-3-phosphate responsive antiterminator; Region: G3P_antiterm; cl00852 508765002952 glycerol kinase; Provisional; Region: glpK; PRK00047 508765002953 Escherichia coli glycerol kinase-like proteins; belongs to the FGGY family of carbohydrate kinases; Region: FGGY_EcGK_like; cd07786 508765002954 N- and C-terminal domain interface [polypeptide binding]; other site 508765002955 active site 508765002956 MgATP binding site [chemical binding]; other site 508765002957 catalytic site [active] 508765002958 metal binding site [ion binding]; metal-binding site 508765002959 glycerol binding site [chemical binding]; other site 508765002960 homotetramer interface [polypeptide binding]; other site 508765002961 homodimer interface [polypeptide binding]; other site 508765002962 FBP binding site [chemical binding]; other site 508765002963 protein IIAGlc interface [polypeptide binding]; other site 508765002964 Predicted dehydrogenase [General function prediction only]; Region: COG0579 508765002965 hydroxyglutarate oxidase; Provisional; Region: PRK11728 508765002966 BFD-like [2Fe-2S] binding domain; Region: Fer2_BFD; pfam04324 508765002967 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox_2; pfam07992 508765002968 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500 508765002969 Uncharacterized protein with conserved CXXC pairs [Function unknown]; Region: COG3862 508765002970 aspartate kinase; Reviewed; Region: PRK09034 508765002971 Amino Acid Kinases (AAK) superfamily, catalytic domain; present in such enzymes like N-acetylglutamate kinase (NAGK), carbamate kinase (CK), aspartokinase (AK), glutamate-5-kinase (G5K) and UMP kinase (UMPK). The AAK superfamily includes kinases that...; Region: AAK; cl00452 508765002972 nucleotide binding site [chemical binding]; other site 508765002973 substrate binding site [chemical binding]; other site 508765002974 ACT domains located C-terminal to the catalytic domain of the lysine plus threonine-sensitive aspartokinase isoenzyme AKIII; Region: ACT_AKiii-YclM-BS_1; cd04911 508765002975 allosteric regulatory residue; other site 508765002976 ACT domains located C-terminal to the catalytic domain of the lysine plus threonine-sensitive aspartokinase isoenzyme AKIII; Region: ACT_AKiii-YclM-BS_2; cd04916 508765002977 glutamate synthase subunit alpha; Provisional; Region: gltB; PRK11750 508765002978 Glutamine amidotransferases class-II (Gn-AT), glutamate synthase (GltS)-type. GltS is a homodimer that synthesizes L-glutamate from 2-oxoglutarate and L-glutamine, an important step in ammonia assimilation in bacteria, cyanobacteria and plants. The...; Region: GltS; cd00713 508765002979 active site 508765002980 dimer interface [polypeptide binding]; other site 508765002981 Glutamate synthase central domain; Region: Glu_syn_central; pfam04898 508765002982 Glutamate synthase (GltS) FMN-binding domain. GltS is a complex iron-sulfur flavoprotein that catalyzes the reductive synthesis of L-glutamate from 2-oxoglutarate and L-glutamine via intramolecular channelling of ammonia, a reaction in the plant, yeast...; Region: GltS_FMN; cd02808 508765002983 active site 508765002984 FMN binding site [chemical binding]; other site 508765002985 substrate binding site [chemical binding]; other site 508765002986 3Fe-4S cluster binding site [ion binding]; other site 508765002987 gltb_C. This domain is found at the C-terminus of the large subunit (gltB) of glutamate synthase (GltS). GltS encodes a complex iron-sulfur flavoprotein that catalyzes the synthesis of L-glutamate from L-glutamine and 2-oxoglutarate. It requires the...; Region: gltB_C; cd00982 508765002988 domain interface; other site 508765002989 glutamate synthase subunit beta; Reviewed; Region: gltD; PRK12810 508765002990 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 508765002991 inner membrane transporter YjeM; Provisional; Region: PRK15238 508765002992 CarD-like/TRCF domain; Region: CarD_CdnL_TRCF; cl00588 508765002993 Rubrerythrin [Energy production and conversion]; Region: COG1592 508765002994 Rubrerythrin, ferritin-like diiron-binding domain; Region: Rubrerythrin; cd01041 508765002995 binuclear metal center [ion binding]; other site 508765002996 Rubredoxin, Small Modular nonheme iron binding domain containing a [Fe(SCys)4] center, present in rubrerythrin and nigerythrin and detected either N- or C-terminal to such proteins as flavin reductase, NAD(P)H-nitrite reductase, and...; Region: rubredoxin_SM; cd00729 508765002997 iron binding site [ion binding]; other site 508765002998 Uridine kinase [Nucleotide transport and metabolism]; Region: Udk; COG0572 508765002999 Uridine monophosphate kinase (UMPK, EC 2.7.1.48), also known as uridine kinase or uridine-cytidine kinase (UCK), catalyzes the reversible phosphoryl transfer from ATP to uridine or cytidine to yield UMP or CMP. In the primidine nucleotide-salvage pathway; Region: UMPK; cd02023 508765003000 ATP-binding site [chemical binding]; other site 508765003001 Sugar specificity; other site 508765003002 Pyrimidine base specificity; other site 508765003003 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4399 508765003004 Na+/phosphate symporter [Inorganic ion transport and metabolism]; Region: NptA; COG1283 508765003005 Na+/Pi-cotransporter; Region: Na_Pi_cotrans; pfam02690 508765003006 Na+/Pi-cotransporter; Region: Na_Pi_cotrans; pfam02690 508765003007 PhoU domain; Region: PhoU; pfam01895 508765003008 PhoU domain; Region: PhoU; pfam01895 508765003009 ribonuclease Z; Reviewed; Region: PRK00055 508765003010 Predicted Zn-dependent hydrolases of the beta-lactamase fold [General function prediction only]; Region: COG2220 508765003011 Predicted phosphatases [General function prediction only]; Region: Gph; COG0546 508765003012 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 508765003013 motif II; other site 508765003014 Predicted permease, member of the PurR regulon [General function prediction only]; Region: yhhT; COG0628 508765003015 Domain of unknown function DUF20; Region: UPF0118; pfam01594 508765003016 A circularly permuted ATPgrasp; Region: CP_ATPgrasp_1; cl17448 508765003017 Glutathionylspermidine synthase preATP-grasp; Region: GSP_synth; pfam03738 508765003018 Domain of Unknown Function (DUF350); Region: DUF350; pfam03994 508765003019 Cache domain; Region: Cache_1; pfam02743 508765003020 Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer); Region: MA; smart00283 508765003021 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 508765003022 dimer interface [polypeptide binding]; other site 508765003023 putative CheW interface [polypeptide binding]; other site 508765003024 TRX family; composed of two groups: Group I, which includes proteins that exclusively encode a TRX domain; and Group II, which are composed of fusion proteins of TRX and additional domains. Group I TRX is a small ancient protein that alter the redox...; Region: TRX_family; cd02947 508765003025 catalytic residues [active] 508765003026 threonine dehydratase; Provisional; Region: PRK08198 508765003027 Threonine dehydratase: The first step in amino acid degradation is the removal of nitrogen. Although the nitrogen atoms of most amino acids are transferred to alpha-ketoglutarate before removal, the alpha-amino group of threonine can be directly...; Region: Thr-dehyd; cd01562 508765003028 tetramer interface [polypeptide binding]; other site 508765003029 pyridoxal 5'-phosphate binding site [chemical binding]; other site 508765003030 catalytic residue [active] 508765003031 C-terminal ACT domain of biodegradative (catabolic) threonine dehydratase II (ThrD-II) and other related ACT domains; Region: ACT_ThrD-II-like; cd04886 508765003032 Uncharacterized conserved protein [Function unknown]; Region: COG2966 508765003033 Protein of unknown function (DUF1212); Region: DUF1212; pfam06738 508765003034 Protein of unknown function (DUF3815); Region: DUF3815; pfam12821 508765003035 Predicted Co/Zn/Cd cation transporters [Inorganic ion transport and metabolism]; Region: MMT1; COG0053 508765003036 Cation efflux family; Region: Cation_efflux; cl00316 508765003037 K+-dependent Na+/Ca+ exchanger related-protein; Region: TIGR00367 508765003038 Sodium/calcium exchanger protein; Region: Na_Ca_ex; pfam01699 508765003039 Sodium/calcium exchanger protein; Region: Na_Ca_ex; pfam01699 508765003040 ATPase components of ABC transporters with duplicated ATPase domains [General function prediction only]; Region: Uup; COG0488 508765003041 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 508765003042 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 508765003043 ABC transporter; Region: ABC_tran_2; pfam12848 508765003044 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 508765003045 Branched-chain amino acid transport protein; Region: Branch_AA_trans; pfam05525 508765003046 Domain of unknown function (DUF2935); Region: DUF2935; pfam11155 508765003047 Domain of unknown function (DUF2935); Region: DUF2935; pfam11155 508765003048 ASC-1 homology domain, subfamily similar to Enterococcus faecalis Ef3133. The ASCH domain, a small beta-barrel domain found in all three kingdoms of life, resembles the RNA-binding PUA domain and may also interact with RNA. ASCH has been proposed to...; Region: ASCH_Ef3133_like; cd06553 508765003049 serine hydroxymethyltransferase; Reviewed; Region: glyA; PRK00011 508765003050 Serine-glycine hydroxymethyltransferase (SHMT). This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). SHMT carries out interconversion of serine and glycine; it catalyzes the transfer of hydroxymethyl...; Region: SHMT; cd00378 508765003051 dimer interface [polypeptide binding]; other site 508765003052 active site 508765003053 glycine-pyridoxal phosphate binding site [chemical binding]; other site 508765003054 folate binding site [chemical binding]; other site 508765003055 Escherichia coli YbbF/LpxH and related proteins, metallophosphatase domain; Region: MPP_YbbF-LpxH; cd07398 508765003056 putative active site [active] 508765003057 putative metal binding site [ion binding]; other site 508765003058 Zn-dependent dipeptidase, microsomal dipeptidase homolog [Amino acid transport and metabolism]; Region: COG2355 508765003059 renal dipeptidase (rDP), best studied in mammals and also called membrane or microsomal dipeptidase, is a membrane-bound glycoprotein hydrolyzing dipeptides and is involved in hydrolytic metabolism of penem and carbapenem beta-lactam antibiotics; Region: rDP_like; cd01301 508765003060 active site 508765003061 dimer interface [polypeptide binding]; other site 508765003062 3-ketoacyl-(acyl-carrier-protein) reductase; Provisional; Region: fabG; PRK05565 508765003063 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 508765003064 NAD(P) binding site [chemical binding]; other site 508765003065 active site 508765003066 branched-chain amino acid aminotransferase; Provisional; Region: PRK13357 508765003067 BCAT_beta_family: Branched-chain aminotransferase catalyses the transamination of the branched-chain amino acids leusine, isoleucine and valine to their respective alpha-keto acids, alpha-ketoisocaproate, alpha-keto-beta-methylvalerate and...; Region: BCAT_beta_family; cd01557 508765003068 homodimer interface [polypeptide binding]; other site 508765003069 substrate-cofactor binding pocket; other site 508765003070 catalytic residue [active] 508765003071 NAD synthetase; Reviewed; Region: nadE; PRK02628 508765003072 Glutamine aminotransferase (GAT, glutaminase) domain of glutamine-dependent NAD synthetases (class 7 and 8 nitrilases); Region: GAT_Gln-NAD-synth; cd07570 508765003073 multimer interface [polypeptide binding]; other site 508765003074 active site 508765003075 catalytic triad [active] 508765003076 protein interface 1 [polypeptide binding]; other site 508765003077 NAD+ synthase is a homodimer, which catalyzes the final step in de novo nicotinamide adenine dinucleotide (NAD+) biosynthesis, an amide transfer from either ammonia or glutamine to nicotinic acid adenine dinucleotide (NaAD). The conversion of NaAD to NAD...; Region: NAD_synthase; cd00553 508765003078 homodimer interface [polypeptide binding]; other site 508765003079 NAD binding pocket [chemical binding]; other site 508765003080 ATP binding pocket [chemical binding]; other site 508765003081 Mg binding site [ion binding]; other site 508765003082 active-site loop [active] 508765003083 Membrane protein implicated in regulation of membrane protease activity [Posttranslational modification, protein turnover, chaperones / Intracellular trafficking and secretion]; Region: COG1585 508765003084 Membrane protease subunits, stomatin/prohibitin homologs [Posttranslational modification, protein turnover, chaperones]; Region: HflC; COG0330 508765003085 Band_7_stomatin_like: A subgroup of the band 7 domain of flotillin (reggie) like proteins similar to stomatin and podicin (two lipid raft-associated integral membrane proteins). Individual proteins of this band 7 domain family may cluster to form...; Region: Band_7_stomatin_like; cd03403 508765003086 Sodium:dicarboxylate symporter family; Region: SDF; pfam00375 508765003087 Na+/H+-dicarboxylate symporters [Energy production and conversion]; Region: GltP; COG1301 508765003088 multidrug efflux pump VmrA; Reviewed; Region: vmrA; PRK09575 508765003089 Subfamily of the multidrug and toxic compound extrusion (MATE)-like proteins similar to Streptococcus aureus MepA; Region: MATE_MepA_like; cd13143 508765003090 Helix-Turn-Helix DNA binding domain of MerR-like transcription regulators; Region: HTH_MerR-like; cd00592 508765003091 MerR HTH family regulatory protein; Region: MerR_1; pfam13411 508765003092 DNA binding residues [nucleotide binding] 508765003093 dimer interface [polypeptide binding]; other site 508765003094 GyrI-like small molecule binding domain; Region: GyrI-like; cl01368 508765003095 Bacterial extracellular solute-binding proteins, family 3; Region: SBP_bac_3; pfam00497 508765003096 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 508765003097 substrate binding pocket [chemical binding]; other site 508765003098 membrane-bound complex binding site; other site 508765003099 hinge residues; other site 508765003100 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 508765003101 dimer interface [polypeptide binding]; other site 508765003102 conserved gate region; other site 508765003103 putative PBP binding loops; other site 508765003104 ABC-ATPase subunit interface; other site 508765003105 glutamine ABC transporter ATP-binding protein; Reviewed; Region: glnQ; PRK09493 508765003106 ATP-binding cassette domain of the histidine and glutamine transporters; Region: ABC_HisP_GlnQ; cd03262 508765003107 Walker A/P-loop; other site 508765003108 ATP binding site [chemical binding]; other site 508765003109 Q-loop/lid; other site 508765003110 ABC transporter signature motif; other site 508765003111 Walker B; other site 508765003112 D-loop; other site 508765003113 H-loop/switch region; other site 508765003114 Probable zinc-binding domain; Region: zf-trcl; pfam13451 508765003115 Chloride channel protein EriC [Inorganic ion transport and metabolism]; Region: EriC; COG0038 508765003116 CLC voltage-gated chloride channel. The ClC chloride channels catalyse the selective flow of Cl- ions across cell membranes, thereby regulating electrical excitation in skeletal muscle and the flow of salt and water across epithelial barriers. This...; Region: Voltage_gated_ClC; cl02915 508765003117 Cl- selectivity filter; other site 508765003118 Cl- binding residues [ion binding]; other site 508765003119 pore gating glutamate residue; other site 508765003120 dimer interface [polypeptide binding]; other site 508765003121 phosphoribosylformylglycinamidine synthase, clade II; Region: FGAM-synthase; TIGR01857 508765003122 AIR (aminoimidazole ribonucleotide) synthase related protein. This family includes Hydrogen expression/formation protein HypE, AIR synthases, FGAM (formylglycinamidine ribonucleotide) synthase and Selenophosphate synthetase (SelD). The N-terminal domain...; Region: PurM-like; cl10019 508765003123 PurL subunit of the formylglycinamide ribonucleotide amidotransferase (FGAR-AT), first repeat. FGAR-AT catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to formylglycinamidine ribonucleotide (FGAM), ADP; Region: PurL_repeat1; cd02203 508765003124 dimerization interface [polypeptide binding]; other site 508765003125 ATP binding site [chemical binding]; other site 508765003126 PurL subunit of the formylglycinamide ribonucleotide amidotransferase (FGAR-AT), second repeat. FGAR-AT catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to formylglycinamidine ribonucleotide (FGAM), ADP; Region: PurL_repeat2; cd02204 508765003127 dimerization interface [polypeptide binding]; other site 508765003128 ATP binding site [chemical binding]; other site 508765003129 Type 1 glutamine amidotransferase (GATase1)-like domain found in Formylglycinamide ribonucleotide amidotransferase; Region: GATase1_FGAR_AT; cd01740 508765003130 putative active site [active] 508765003131 catalytic triad [active] 508765003132 Phosphoribosylcarboxyaminoimidazole (NCAIR) mutase [Nucleotide transport and metabolism]; Region: PurE; COG0041 508765003133 phosphoribosylaminoimidazole-succinocarboxamide synthase; Reviewed; Region: PRK09362 508765003134 bacterial and archaeal 5-aminoimidazole-4-(N-succinylcarboxamide) ribonucleotide (SAICAR) synthase; Region: SAICAR_synt_PurC; cd01415 508765003135 ATP binding site [chemical binding]; other site 508765003136 active site 508765003137 substrate binding site [chemical binding]; other site 508765003138 amidophosphoribosyltransferase; Provisional; Region: PRK05793 508765003139 Glutamine amidotransferases class-II (GN-AT)_GPAT- type. This domain is found at the N-terminus of glutamine phosphoribosylpyrophosphate (Prpp) amidotransferase (GPATase) . The glutaminase domain catalyzes amide nitrogen transfer from glutamine to the...; Region: GPATase_N; cd00715 508765003140 active site 508765003141 tetramer interface [polypeptide binding]; other site 508765003142 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 508765003143 active site 508765003144 phosphoribosylaminoimidazole synthetase; Provisional; Region: PRK05385 508765003145 PurM (Aminoimidazole Ribonucleotide [AIR] synthetase), one of eleven enzymes required for purine biosynthesis, catalyzes the conversion of formylglycinamide ribonucleotide (FGAM) and ATP to AIR, ADP, and Pi, the fifth step in de novo purine biosynthesis; Region: PurM; cd02196 508765003146 dimerization interface [polypeptide binding]; other site 508765003147 putative ATP binding site [chemical binding]; other site 508765003148 phosphoribosylglycinamide formyltransferase; Reviewed; Region: purN; PRK05647 508765003149 Phosphoribosylglycinamide formyltransferase (GAR transformylase, GART); Region: FMT_core_GART; cd08645 508765003150 active site 508765003151 substrate binding site [chemical binding]; other site 508765003152 cosubstrate binding site; other site 508765003153 catalytic site [active] 508765003154 bifunctional phosphoribosylaminoimidazolecarboxamide formyltransferase/IMP cyclohydrolase; Provisional; Region: purH; PRK00881 508765003155 Inosine monophosphate cyclohydrolase domain. This is the N-terminal domain in the purine biosynthesis pathway protein ATIC (purH). The bifunctional ATIC protein contains a C-terminal ATIC formylase domain that formylates...; Region: IMPCH; cd01421 508765003156 purine monophosphate binding site [chemical binding]; other site 508765003157 dimer interface [polypeptide binding]; other site 508765003158 putative catalytic residues [active] 508765003159 AICARFT/IMPCHase bienzyme; Region: AICARFT_IMPCHas; smart00798 508765003160 AICARFT/IMPCHase bienzyme; Region: AICARFT_IMPCHas; cl03362 508765003161 phosphoribosylamine--glycine ligase; Provisional; Region: PRK00885 508765003162 Phosphoribosylglycinamide synthetase, N domain; Region: GARS_N; pfam02844 508765003163 Phosphoribosylglycinamide synthetase, ATP-grasp (A) domain; Region: GARS_A; pfam01071 508765003164 Phosphoribosylglycinamide synthetase, C domain; Region: GARS_C; pfam02843 508765003165 acetyl coenzyme A synthetase (ADP forming), alpha domain; Region: AcCoA-syn-alpha; TIGR02717 508765003166 CoA binding domain; Region: CoA_binding_2; pfam13380 508765003167 Succinyl-CoA ligase like flavodoxin domain; Region: Succ_CoA_lig; pfam13607 508765003168 Glycine/D-amino acid oxidases (deaminating) [Amino acid transport and metabolism]; Region: DadA; COG0665 508765003169 Rieske Fe-S protein [Energy production and conversion]; Region: QcrA; COG0723 508765003170 Rieske domain; a [2Fe-2S] cluster binding domain commonly found in Rieske non-heme iron oxygenase (RO) systems such as naphthalene and biphenyl dioxygenases, as well as in plant/cyanobacterial chloroplast b6f and mitochondrial cytochrome bc(1) complexes; Region: Rieske; cl00938 508765003171 iron-sulfur cluster [ion binding]; other site 508765003172 [2Fe-2S] cluster binding site [ion binding]; other site 508765003173 Helix-Turn-Helix DNA binding domain of the transcription regulators TipAL, Mta, and SkgA; Region: HTH_TipAL-Mta; cd01106 508765003174 MerR HTH family regulatory protein; Region: MerR_1; pfam13411 508765003175 DNA binding residues [nucleotide binding] 508765003176 TipAS antibiotic-recognition domain; Region: TipAS; pfam07739 508765003177 LytTr DNA-binding domain; Region: LytTR; smart00850 508765003178 EDD domain protein, DegV family; Region: DegV; TIGR00762 508765003179 Uncharacterized protein, DegV family COG1307; Region: DegV; pfam02645 508765003180 probable dihydroxyacetone kinase regulator; Region: DHAK_reg; TIGR02366 508765003181 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 508765003182 ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136 508765003183 ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255 508765003184 Walker A/P-loop; other site 508765003185 ATP binding site [chemical binding]; other site 508765003186 Q-loop/lid; other site 508765003187 ABC transporter signature motif; other site 508765003188 Walker B; other site 508765003189 D-loop; other site 508765003190 H-loop/switch region; other site 508765003191 ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136 508765003192 ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255 508765003193 Walker A/P-loop; other site 508765003194 ATP binding site [chemical binding]; other site 508765003195 Q-loop/lid; other site 508765003196 ABC transporter signature motif; other site 508765003197 Walker B; other site 508765003198 D-loop; other site 508765003199 H-loop/switch region; other site 508765003200 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 508765003201 OpgC protein; Region: OpgC_C; cl17858 508765003202 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 508765003203 ATP binding site [chemical binding]; other site 508765003204 Mg2+ binding site [ion binding]; other site 508765003205 G-X-G motif; other site 508765003206 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 508765003207 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 508765003208 active site 508765003209 phosphorylation site [posttranslational modification] 508765003210 intermolecular recognition site; other site 508765003211 dimerization interface [polypeptide binding]; other site 508765003212 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 508765003213 DNA binding site [nucleotide binding] 508765003214 TraX protein; Region: TraX; cl05434 508765003215 Probable zinc-binding domain; Region: zf-trcl; pfam13451 508765003216 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 508765003217 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 508765003218 active site 508765003219 phosphorylation site [posttranslational modification] 508765003220 intermolecular recognition site; other site 508765003221 dimerization interface [polypeptide binding]; other site 508765003222 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 508765003223 DNA binding site [nucleotide binding] 508765003224 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 508765003225 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 508765003226 dimerization interface [polypeptide binding]; other site 508765003227 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 508765003228 dimer interface [polypeptide binding]; other site 508765003229 phosphorylation site [posttranslational modification] 508765003230 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 508765003231 ATP binding site [chemical binding]; other site 508765003232 Mg2+ binding site [ion binding]; other site 508765003233 G-X-G motif; other site 508765003234 Protein of unknown function (DUF3919); Region: DUF3919; pfam13057 508765003235 Bacterial extracellular solute-binding protein; Region: SBP_bac_8; pfam13416 508765003236 ABC-type Fe3+ transport system, periplasmic component [Inorganic ion transport and metabolism]; Region: AfuA; COG1840 508765003237 sugar phosphate antiporter; Reviewed; Region: uhpT; PRK09556 508765003238 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 508765003239 putative substrate translocation pore; other site 508765003240 Predicted membrane protein [Function unknown]; Region: COG2717 508765003241 Predicted membrane protein, putative toxin regulator [General function prediction only]; Region: PfoR; COG3641 508765003242 Phosphotransferase system, EIIC; Region: PTS_EIIC_2; pfam13303 508765003243 2-dehydropantoate 2-reductase; Reviewed; Region: PRK06522 508765003244 Ketopantoate reductase PanE/ApbA; Region: ApbA; pfam02558 508765003245 Ketopantoate reductase PanE/ApbA C terminal; Region: ApbA_C; pfam08546 508765003246 MarR family; Region: MarR_2; pfam12802 508765003247 Uncharacterized conserved protein [Function unknown]; Region: COG0398 508765003248 SNARE associated Golgi protein; Region: SNARE_assoc; pfam09335 508765003249 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 508765003250 TPR repeat; Region: TPR_11; pfam13414 508765003251 binding surface 508765003252 TPR motif; other site 508765003253 TPR repeat; Region: TPR_11; pfam13414 508765003254 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 508765003255 binding surface 508765003256 TPR motif; other site 508765003257 TPR repeat; Region: TPR_11; pfam13414 508765003258 TPR repeat; Region: TPR_11; pfam13414 508765003259 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 508765003260 binding surface 508765003261 TPR motif; other site 508765003262 TPR repeat; Region: TPR_11; pfam13414 508765003263 Flavin Reductases; Region: FlaRed; cl00801 508765003264 MarR family; Region: MarR_2; pfam12802 508765003265 3-oxoacyl-(acyl carrier protein) synthase III; Reviewed; Region: PRK09352 508765003266 Ketoacyl-acyl carrier protein synthase III (KASIII) initiates the elongation in type II fatty acid synthase systems. It is found in bacteria and plants. Elongation of fatty acids in the type II systems occurs by Claisen condensation of malonyl-acyl...; Region: KAS_III; cd00830 508765003267 dimer interface [polypeptide binding]; other site 508765003268 active site 508765003269 CoA binding pocket [chemical binding]; other site 508765003270 acyl carrier protein; Provisional; Region: acpP; PRK00982 508765003271 putative enoyl-[acyl-carrier-protein] reductase II; Region: enACPred_II; TIGR03151 508765003272 2-Nitropropane dioxygenase (NPD), one of the nitroalkane oxidizing enzyme families, catalyzes oxidative denitrification of nitroalkanes to their corresponding carbonyl compounds and nitrites. NDP is a member of the NAD(P)H-dependent flavin oxidoreductase...; Region: NPD_like; cd04730 508765003273 FMN binding site [chemical binding]; other site 508765003274 substrate binding site [chemical binding]; other site 508765003275 putative catalytic residue [active] 508765003276 (acyl-carrier-protein) S-malonyltransferase [Lipid metabolism]; Region: FabD; COG0331 508765003277 malonyl CoA-acyl carrier protein transacylase; Region: fabD; TIGR00128 508765003278 3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05557 508765003279 beta-Keto acyl carrier protein reductase (BKR), involved in Type II FAS, classical (c) SDRs; Region: BKR_SDR_c; cd05333 508765003280 NAD(P) binding site [chemical binding]; other site 508765003281 homotetramer interface [polypeptide binding]; other site 508765003282 homodimer interface [polypeptide binding]; other site 508765003283 active site 508765003284 beta-ketoacyl-acyl-carrier-protein synthase II; Region: fabF; TIGR03150 508765003285 Beta-ketoacyl-acyl carrier protein (ACP) synthase (KAS), type I and II. KASs are responsible for the elongation steps in fatty acid biosynthesis. KASIII catalyses the initial condensation and KAS I and II catalyze further elongation steps by Claisen...; Region: KAS_I_II; cd00834 508765003286 dimer interface [polypeptide binding]; other site 508765003287 active site 508765003288 acetyl-CoA carboxylase biotin carboxyl carrier protein subunit; Validated; Region: PRK06302 508765003289 The biotinyl-domain or biotin carboxyl carrier protein (BCCP) domain is present in all biotin-dependent enzymes, such as acetyl-CoA carboxylase, pyruvate carboxylase, propionyl-CoA carboxylase, methylcrotonyl-CoA carboxylase, geranyl-CoA carboxylase; Region: biotinyl_domain; cd06850 508765003290 carboxyltransferase (CT) interaction site; other site 508765003291 biotinylation site [posttranslational modification]; other site 508765003292 FabZ is a 17kD beta-hydroxyacyl-acyl carrier protein (ACP) dehydratase that primarily catalyzes the dehydration of beta-hydroxyacyl-ACP to trans-2-acyl-ACP, the third step in the elongation phase of the bacterial/ plastid, type II, fatty-acid...; Region: FabZ; cd01288 508765003293 biotin carboxylase; Validated; Region: PRK05586 508765003294 Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289 508765003295 Carbamoyl-phosphate synthase L chain, ATP binding domain; Region: CPSase_L_D2; pfam02786 508765003296 Biotin carboxylase C-terminal domain; Region: Biotin_carb_C; smart00878 508765003297 acetyl-CoA carboxylase subunit beta; Validated; Region: PRK05654 508765003298 RNA polymerases M/15 Kd subunit; Region: RNA_POL_M_15KD; cl02717 508765003299 malonate decarboxylase subunit beta; Reviewed; Region: PRK07189; cl17682 508765003300 acetyl-CoA carboxylase carboxyltransferase subunit alpha; Validated; Region: PRK05724 508765003301 Protein of unknown function (DUF4003); Region: DUF4003; pfam13170 508765003302 Histidine Utilizing Protein, the hut operon positive regulatory protein; Region: HutP; cd11640 508765003303 hexamer interface [polypeptide binding]; other site 508765003304 RNA binding site [nucleotide binding]; other site 508765003305 Histidine-zinc binding site [chemical binding]; other site 508765003306 3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05653 508765003307 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 508765003308 NAD(P) binding site [chemical binding]; other site 508765003309 active site 508765003310 selenium-dependent molybdenum hydroxylase 1; Region: Se_dep_Molyb_1; TIGR03311 508765003311 2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207 508765003312 catalytic loop [active] 508765003313 iron binding site [ion binding]; other site 508765003314 [2Fe-2S] binding domain; Region: Fer2_2; pfam01799 508765003315 Aldehyde oxidase and xanthine dehydrogenase, a/b hammerhead domain; Region: Ald_Xan_dh_C; smart01008 508765003316 Molybdopterin-binding domain of aldehyde dehydrogenase; Region: Ald_Xan_dh_C2; pfam02738 508765003317 GT_2_like_f is a subfamily of the glycosyltransferase family 2 (GT-2) with unknown function; Region: GT_2_like_f; cd04182 508765003318 Ligand binding site; other site 508765003319 metal-binding site 508765003320 MoeA_like. This domain is similar to a domain found in a variety of proteins involved in biosynthesis of molybdopterin cofactor, like MoaB, MogA, and MoeA. There this domain is presumed to bind molybdopterin. The exact function of this subgroup is...; Region: MoeA_like; cd03522 508765003321 putative MPT binding site; other site 508765003322 MoaC family, prokaryotic and eukaryotic. Members of this family are involved in molybdenum cofactor (Moco) biosynthesis, an essential cofactor of a diverse group of redox enzymes. MoaC, a small hexameric protein, converts, together with MoaA, a guanosine...; Region: MoaC_PE; cd01420 508765003323 trimer interface [polypeptide binding]; other site 508765003324 dimer interface [polypeptide binding]; other site 508765003325 putative active site [active] 508765003326 molybdenum cofactor biosynthesis protein A; Reviewed; Region: moaA; PRK00164 508765003327 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 508765003328 FeS/SAM binding site; other site 508765003329 Molybdenum Cofactor Synthesis C; Region: Mob_synth_C; pfam06463 508765003330 MOSC domain; Region: MOSC; pfam03473 508765003331 recombination factor protein RarA; Reviewed; Region: PRK13342 508765003332 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 508765003333 Walker A motif; other site 508765003334 ATP binding site [chemical binding]; other site 508765003335 Walker B motif; other site 508765003336 arginine finger; other site 508765003337 MgsA AAA+ ATPase C terminal; Region: MgsA_C; pfam12002 508765003338 Predicted transcriptional regulator [Transcription]; Region: COG1959 508765003339 Transcriptional regulator; Region: Rrf2; cl17282 508765003340 Cysteine sulfinate desulfinase/cysteine desulfurase and related enzymes [Amino acid transport and metabolism]; Region: NifS; COG1104 508765003341 cysteine desulfurase NifS; Region: FeS_nifS; TIGR03402 508765003342 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 508765003343 catalytic residue [active] 508765003344 NifU homolog involved in Fe-S cluster formation [Energy production and conversion]; Region: IscU; COG0822 508765003345 Iron-sulfur cluster scaffold-like proteins; Region: IscU_like; cd06664 508765003346 trimerization site [polypeptide binding]; other site 508765003347 active site 508765003348 Predicted tRNA(5-methylaminomethyl-2-thiouridylate) methyltransferase, contains the PP-loop ATPase domain [Translation, ribosomal structure and biogenesis]; Region: TrmU; COG0482 508765003349 tRNA methyl transferase. This family represents tRNA(5-methylaminomethyl-2-thiouridine)-methyltransferase which is involved in the biosynthesis of the modified nucleoside 5-methylaminomethyl-2-thiouridine present in the wobble position of some tRNAs; Region: tRNA_Me_trans; cd01998 508765003350 Ligand Binding Site [chemical binding]; other site 508765003351 PRC-barrel domain containing protein [General function prediction only]; Region: COG3881 508765003352 Protein implicated in RNA metabolism, contains PRC-barrel domain [General function prediction only]; Region: COG1873; cl17889 508765003353 Domain of unknown function DUF20; Region: UPF0118; pfam01594 508765003354 Predicted permease, member of the PurR regulon [General function prediction only]; Region: yhhT; COG0628 508765003355 T-box leader 508765003356 alanyl-tRNA synthetase; Reviewed; Region: alaS; PRK00252 508765003357 Alanyl-tRNA synthetase (AlaRS) class II core catalytic domain. AlaRS is a homodimer. It is responsible for the attachment of alanine to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for ATP-dependent...; Region: AlaRS_core; cd00673 508765003358 motif 1; other site 508765003359 active site 508765003360 motif 2; other site 508765003361 motif 3; other site 508765003362 Threonyl and Alanyl tRNA synthetase second additional domain; Region: tRNA_SAD; pfam07973 508765003363 DHHA1 domain; Region: DHHA1; pfam02272 508765003364 hypothetical protein; Provisional; Region: PRK05473 508765003365 Holliday junction resolvase-like protein; Reviewed; Region: PRK00109 508765003366 Protein of unknown function (DUF1292); Region: DUF1292; cl01608 508765003367 ferric uptake regulator; Provisional; Region: fur; PRK09462 508765003368 Ferric uptake regulator(Fur) and related metalloregulatory proteins; typically iron-dependent, DNA-binding repressors and activators; Region: Fur_like; cd07153 508765003369 metal binding site 2 [ion binding]; metal-binding site 508765003370 putative DNA binding helix; other site 508765003371 metal binding site 1 [ion binding]; metal-binding site 508765003372 dimer interface [polypeptide binding]; other site 508765003373 structural Zn2+ binding site [ion binding]; other site 508765003374 mRNA degradation ribonucleases J1/J2 (metallo-beta-lactamase superfamily) [Translation, ribosomal structure and biogenesis; Replication, recombination and repair]; Region: COG0595 508765003375 Metallo-beta-lactamase superfamily; Region: Lactamase_B; smart00849 508765003376 RNA-metabolising metallo-beta-lactamase; Region: RMMBL; pfam07521 508765003377 Predicted membrane GTPase involved in stress response [Signal transduction mechanisms]; Region: TypA; COG1217 508765003378 Tyrosine phosphorylated protein A (TypA)/BipA family belongs to ribosome-binding GTPases; Region: TypA_BipA; cd01891 508765003379 G1 box; other site 508765003380 putative GEF interaction site [polypeptide binding]; other site 508765003381 GTP/Mg2+ binding site [chemical binding]; other site 508765003382 Switch I region; other site 508765003383 G2 box; other site 508765003384 G3 box; other site 508765003385 Switch II region; other site 508765003386 G4 box; other site 508765003387 G5 box; other site 508765003388 BipA_TypA_II: domain II of BipA (also called TypA) having homology to domain II of the elongation factors (EFs) EF-G and EF-Tu. BipA is a highly conserved protein with global regulatory properties in Escherichia coli. BipA is phosphorylated on a...; Region: BipA_TypA_II; cd03691 508765003389 BipA_TypA_C: a C-terminal portion of BipA or TypA having homology to the C terminal domains of the elongation factors EF-G and EF-2. A member of the ribosome binding GTPase superfamily, BipA is widely distributed in bacteria and plants. BipA is a highly...; Region: BipA_TypA_C; cd03710 508765003390 YceG-like family; Region: YceG; pfam02618 508765003391 proteins similar to Escherichia coli yceG; Region: yceG_like; cd08010 508765003392 dimerization interface [polypeptide binding]; other site 508765003393 Predicted O-methyltransferase [General function prediction only]; Region: COG4122 508765003394 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 508765003395 S-adenosylmethionine binding site [chemical binding]; other site 508765003396 Collagenase and related proteases [Posttranslational modification, protein turnover, chaperones]; Region: COG0826 508765003397 TIM barrel proteins share a structurally conserved phosphate binding motif and in general share an eight beta/alpha closed barrel structure. Specific for this family is the conserved phosphate binding site at the edges of strands 7 and 8. The phosphate...; Region: TIM_phosphate_binding; cl17186 508765003398 Peptidase family U32; Region: Peptidase_U32; pfam01136 508765003399 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; pfam00905 508765003400 sporulation sigma factor SigK; Reviewed; Region: PRK05803 508765003401 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 508765003402 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 508765003403 DNA binding residues [nucleotide binding] 508765003404 Tfp pilus assembly protein, pilus retraction ATPase PilT [Cell motility and secretion / Intracellular trafficking and secretion]; Region: PilT; COG2805 508765003405 RecA-like NTPases. This family includes the NTP binding domain of F1 and V1 H+ATPases, DnaB and related helicases as well as bacterial RecA and related eukaryotic and archaeal recombinases. This group also includes bacterial conjugation proteins and...; Region: RecA-like_NTPases; cl17233 508765003406 Walker A motif; other site 508765003407 ATP binding site [chemical binding]; other site 508765003408 Walker B motif; other site 508765003409 Cell division ATPase FtsA [Cell division and chromosome partitioning]; Region: ftsA; COG0849 508765003410 Cell division protein FtsA; Region: FtsA; smart00842 508765003411 Cell division protein FtsA; Region: FtsA; pfam14450 508765003412 cell division protein FtsZ; Validated; Region: PRK09330 508765003413 FtsZ is a GTPase that is similar to the eukaryotic tubulins and is essential for cell division in prokaryotes. FtsZ is capable of polymerizing in a GTP-driven process into structures similar to those formed by tubulin. FtsZ forms a ring-shaped septum at...; Region: FtsZ_type1; cd02201 508765003414 nucleotide binding site [chemical binding]; other site 508765003415 SulA interaction site; other site 508765003416 Sporulation factor SpoIIGA; Region: Peptidase_U4; pfam03419 508765003417 sigma-E processing peptidase SpoIIGA; Region: spore_II_GA; TIGR02854 508765003418 DNA-directed RNA polymerase specialized sigma subunit [Transcription]; Region: FliA; COG1191 508765003419 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 508765003420 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 508765003421 DNA binding residues [nucleotide binding] 508765003422 sporulation sigma factor SigG; Reviewed; Region: PRK08215 508765003423 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 508765003424 Sigma-70 region 3; Region: Sigma70_r3; pfam04539 508765003425 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 508765003426 DNA binding residues [nucleotide binding] 508765003427 Protein implicated in RNA metabolism, contains PRC-barrel domain [General function prediction only]; Region: COG1873; cl17889 508765003428 transcriptional regulator NrdR; Validated; Region: nrdR; PRK00464 508765003429 ATP cone domain; Region: ATP-cone; pfam03477 508765003430 Multi-copper polyphenol oxidoreductase laccase; Region: Cu-oxidase_4; pfam02578 508765003431 Multicopper polyphenol oxidase (laccase) [Secondary metabolites biosynthesis, transport and catabolism]; Region: yfiH; COG1496 508765003432 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 508765003433 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 508765003434 active site 508765003435 phosphorylation site [posttranslational modification] 508765003436 intermolecular recognition site; other site 508765003437 dimerization interface [polypeptide binding]; other site 508765003438 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 508765003439 DNA binding site [nucleotide binding] 508765003440 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: VicK; COG5002 508765003441 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 508765003442 dimerization interface [polypeptide binding]; other site 508765003443 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 508765003444 dimer interface [polypeptide binding]; other site 508765003445 phosphorylation site [posttranslational modification] 508765003446 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 508765003447 ATP binding site [chemical binding]; other site 508765003448 Mg2+ binding site [ion binding]; other site 508765003449 G-X-G motif; other site 508765003450 PBP superfamily domain; Region: PBP_like_2; cl17296 508765003451 ABC-type molybdate transport system, periplasmic component [Inorganic ion transport and metabolism]; Region: ModA; COG0725 508765003452 ABC-type phosphate transport system, permease component [Inorganic ion transport and metabolism]; Region: PstC; COG0573 508765003453 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 508765003454 dimer interface [polypeptide binding]; other site 508765003455 conserved gate region; other site 508765003456 putative PBP binding loops; other site 508765003457 ABC-ATPase subunit interface; other site 508765003458 ABC-type phosphate transport system, permease component [Inorganic ion transport and metabolism]; Region: PstA; COG0581 508765003459 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 508765003460 dimer interface [polypeptide binding]; other site 508765003461 conserved gate region; other site 508765003462 putative PBP binding loops; other site 508765003463 ABC-ATPase subunit interface; other site 508765003464 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cl00427 508765003465 phosphate transporter ATP-binding protein; Provisional; Region: PRK14240 508765003466 ATP-binding cassette domain of the phosphate transport system; Region: ABC_PstB_phosphate_transporter; cd03260 508765003467 Walker A/P-loop; other site 508765003468 ATP binding site [chemical binding]; other site 508765003469 Q-loop/lid; other site 508765003470 ABC transporter signature motif; other site 508765003471 Walker B; other site 508765003472 D-loop; other site 508765003473 H-loop/switch region; other site 508765003474 phosphate transport system regulatory protein PhoU; Region: phoU_full; TIGR02135 508765003475 PhoU domain; Region: PhoU; pfam01895 508765003476 PhoU domain; Region: PhoU; pfam01895 508765003477 PDZ domain of bacterial and plant zinc metalloprotases, presumably membrane-associated or integral membrane proteases, which may be involved in signalling and regulatory mechanisms. May be responsible for substrate recognition and/or binding, as most PDZ...; Region: PDZ_metalloprotease; cd00989 508765003478 putative FeS-containing Cyanobacterial-specific oxidoreductase; Region: cyano_FeS_chp; TIGR03279 508765003479 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 508765003480 FeS/SAM binding site; other site 508765003481 Protein of unknown function (DUF512); Region: DUF512; pfam04459 508765003482 GTP-binding protein Der; Reviewed; Region: PRK00093 508765003483 EngA1 GTPase contains the first domain of EngA; Region: EngA1; cd01894 508765003484 G1 box; other site 508765003485 GTP/Mg2+ binding site [chemical binding]; other site 508765003486 Switch I region; other site 508765003487 G2 box; other site 508765003488 Switch II region; other site 508765003489 G3 box; other site 508765003490 G4 box; other site 508765003491 G5 box; other site 508765003492 EngA2 GTPase contains the second domain of EngA; Region: EngA2; cd01895 508765003493 G1 box; other site 508765003494 GTP/Mg2+ binding site [chemical binding]; other site 508765003495 Switch I region; other site 508765003496 G2 box; other site 508765003497 G3 box; other site 508765003498 Switch II region; other site 508765003499 G4 box; other site 508765003500 G5 box; other site 508765003501 NAD(P)H-dependent glycerol-3-phosphate dehydrogenase; Validated; Region: gpsA; PRK00094 508765003502 NAD-dependent glycerol-3-phosphate dehydrogenase N-terminus; Region: NAD_Gly3P_dh_N; pfam01210 508765003503 NAD-dependent glycerol-3-phosphate dehydrogenase C-terminus; Region: NAD_Gly3P_dh_C; pfam07479 508765003504 stage IV sporulation protein A; Region: spore_IV_A; TIGR02836 508765003505 Rat sarcoma (Ras)-like superfamily of small guanosine triphosphatases (GTPases); Region: Ras_like_GTPase; cd00882 508765003506 G1 box; other site 508765003507 GTP/Mg2+ binding site [chemical binding]; other site 508765003508 G2 box; other site 508765003509 Switch I region; other site 508765003510 G3 box; other site 508765003511 Switch II region; other site 508765003512 G4 box; other site 508765003513 G5 box; other site 508765003514 Type II (periplasmic) bacterial L-asparaginase; Region: L-asparaginase_II; cd08964 508765003515 active site 508765003516 homotetramer interface [polypeptide binding]; other site 508765003517 homodimer interface [polypeptide binding]; other site 508765003518 Xanthine/uracil/vitamin C permease [Nucleotide transport and metabolism]; Region: COG2252 508765003519 hypothetical protein; Provisional; Region: PRK11820 508765003520 YicC-like family, N-terminal region; Region: YicC_N; pfam03755 508765003521 Domain of unknown function (DUF1732); Region: DUF1732; pfam08340 508765003522 hypothetical protein; Provisional; Region: PRK04323 508765003523 Guanylate kinase [Nucleotide transport and metabolism]; Region: Gmk; COG0194 508765003524 Guanosine monophosphate kinase (GMPK, EC 2.7.4.8), also known as guanylate kinase (GKase), catalyzes the reversible phosphoryl transfer from adenosine triphosphate (ATP) to guanosine monophosphate (GMP) to yield adenosine diphosphate (ADP) and guanosine...; Region: GMPK; cd00071 508765003525 catalytic site [active] 508765003526 G-X2-G-X-G-K; other site 508765003527 DNA-directed RNA polymerase subunit omega; Reviewed; Region: rpoZ; PRK00392 508765003528 bifunctional phosphopantothenoylcysteine decarboxylase/phosphopantothenate synthase; Validated; Region: PRK05579 508765003529 Flavoprotein; Region: Flavoprotein; pfam02441 508765003530 DNA / pantothenate metabolism flavoprotein; Region: DFP; pfam04127 508765003531 primosome assembly protein PriA; Validated; Region: PRK05580 508765003532 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 508765003533 ATP binding site [chemical binding]; other site 508765003534 putative Mg++ binding site [ion binding]; other site 508765003535 helicase superfamily c-terminal domain; Region: HELICc; smart00490 508765003536 ATP-binding site [chemical binding]; other site 508765003537 Polypeptide or peptide deformylase; a family of metalloenzymes that catalyzes the removal of the N-terminal formyl group in a growing polypeptide chain following translation initiation during protein synthesis in prokaryotes. These enzymes utilize Fe(II)...; Region: Pep_deformylase; cd00487 508765003538 active site 508765003539 catalytic residues [active] 508765003540 metal binding site [ion binding]; metal-binding site 508765003541 methionyl-tRNA formyltransferase; Reviewed; Region: fmt; PRK00005 508765003542 Methionyl-tRNA formyltransferase, N-terminal hydrolase domain; Region: FMT_core_Met-tRNA-FMT_N; cd08646 508765003543 putative active site [active] 508765003544 substrate binding site [chemical binding]; other site 508765003545 putative cosubstrate binding site; other site 508765003546 catalytic site [active] 508765003547 C-terminal domain of Formyltransferase and other enzymes; Region: Met_tRNA_FMT_C; cd08704 508765003548 substrate binding site [chemical binding]; other site 508765003549 Putative neutral zinc metallopeptidase; Region: Zn_peptidase_2; pfam04298 508765003550 16S rRNA methyltransferase B; Provisional; Region: PRK14902 508765003551 NusB family; Region: NusB; pfam01029 508765003552 putative RNA binding site [nucleotide binding]; other site 508765003553 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 508765003554 S-adenosylmethionine binding site [chemical binding]; other site 508765003555 ribosomal RNA large subunit methyltransferase N; Provisional; Region: PRK14454 508765003556 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 508765003557 FeS/SAM binding site; other site 508765003558 Serine/threonine phosphatases, family 2C, catalytic domain; The protein architecture and deduced catalytic mechanism of PP2C phosphatases are similar to the PP1, PP2A, PP2B family of protein Ser/Thr phosphatases, with which PP2C shares no sequence...; Region: PP2Cc; cd00143 508765003559 Protein phosphatase 2C; Region: PP2C; pfam00481 508765003560 active site 508765003561 Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220 508765003562 Catalytic domain of Protein Kinases; Region: PKc; cd00180 508765003563 active site 508765003564 ATP binding site [chemical binding]; other site 508765003565 substrate binding site [chemical binding]; other site 508765003566 activation loop (A-loop); other site 508765003567 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2815 508765003568 PASTA domain of bacterial serine/threonine kinase pknB-like proteins. PknB is a member of a group of related transmembrane sensor kinases present in many gram positive bacteria, which has been shown to regulate cell shape in Mycobacterium tubercolosis; Region: PASTA_pknB; cd06577 508765003569 PASTA domain of bacterial serine/threonine kinase pknB-like proteins. PknB is a member of a group of related transmembrane sensor kinases present in many gram positive bacteria, which has been shown to regulate cell shape in Mycobacterium tubercolosis; Region: PASTA_pknB; cd06577 508765003570 PASTA domain of bacterial serine/threonine kinase pknB-like proteins. PknB is a member of a group of related transmembrane sensor kinases present in many gram positive bacteria, which has been shown to regulate cell shape in Mycobacterium tubercolosis; Region: PASTA_pknB; cd06577 508765003571 GTPase RsgA; Reviewed; Region: PRK00098 508765003572 S1_YloQ_GTPase: YloQ GTase family (also known as YjeQ and CpgA), S1-like RNA-binding domain. Proteins in the YloQ GTase family bind the ribosome and have GTPase activity. The precise role of this family is unknown. The protein structure is composed of...; Region: S1_YloQ_GTPase; cd04466 508765003573 RNA binding site [nucleotide binding]; other site 508765003574 homodimer interface [polypeptide binding]; other site 508765003575 Ribosomal interacting GTPase YjeQ/EngC, a circularly permuted subfamily of the Ras GTPases; Region: YjeQ_EngC; cd01854 508765003576 GTPase/Zn-binding domain interface [polypeptide binding]; other site 508765003577 GTP/Mg2+ binding site [chemical binding]; other site 508765003578 G4 box; other site 508765003579 G5 box; other site 508765003580 G1 box; other site 508765003581 Switch I region; other site 508765003582 G2 box; other site 508765003583 G3 box; other site 508765003584 Switch II region; other site 508765003585 Pentose-5-phosphate-3-epimerase [Carbohydrate transport and metabolism]; Region: Rpe; COG0036 508765003586 Ribulose-5-phosphate 3-epimerase (RPE). This enzyme catalyses the interconversion of D-ribulose 5-phosphate (Ru5P) into D-xylulose 5-phosphate, as part of the Calvin cycle (reductive pentose phosphate pathway) in chloroplasts and in the oxidative pentose...; Region: RPE; cd00429 508765003587 substrate binding site [chemical binding]; other site 508765003588 hexamer interface [polypeptide binding]; other site 508765003589 metal binding site [ion binding]; metal-binding site 508765003590 Thiamine pyrophosphokinase; Region: TPK; cd07995 508765003591 thiamine pyrophosphokinase; Region: thi_PPkinase; TIGR01378 508765003592 active site 508765003593 dimerization interface [polypeptide binding]; other site 508765003594 thiamine binding site [chemical binding]; other site 508765003595 50S ribosomal protein L28; Reviewed; Region: rpmB; PRK00359 508765003596 Asp23 family; Region: Asp23; pfam03780 508765003597 DAK2 domain fusion protein YloV; Region: YloV; TIGR03599 508765003598 DAK2 domain; Region: Dak2; pfam02734 508765003599 ATP-dependent DNA helicase RecG; Provisional; Region: PRK10917 508765003600 Replication protein A, class 2b aminoacyl-tRNA synthetases, and related proteins with oligonucleotide/oligosaccharide (OB) fold; Region: RPA_2b-aaRSs_OBF_like; cl09930 508765003601 generic binding surface I; other site 508765003602 generic binding surface II; other site 508765003603 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 508765003604 ATP binding site [chemical binding]; other site 508765003605 putative Mg++ binding site [ion binding]; other site 508765003606 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 508765003607 nucleotide binding region [chemical binding]; other site 508765003608 ATP-binding site [chemical binding]; other site 508765003609 Conserved hypothetical protein 95; Region: Cons_hypoth95; pfam03602 508765003610 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 508765003611 S-adenosylmethionine binding site [chemical binding]; other site 508765003612 phosphopantetheine adenylyltransferase; Provisional; Region: coaD; PRK00168 508765003613 Phosphopantetheine adenylyltransferase; Region: PPAT; cd02163 508765003614 active site 508765003615 (T/H)XGH motif; other site 508765003616 sporulation integral membrane protein YlbJ; Region: spore_ylbJ; TIGR02871 508765003617 Nucleoside recognition; Region: Gate; pfam07670 508765003618 hypothetical protein; Provisional; Region: PRK13670 508765003619 HIGH Nucleotidyl Transferase; Region: HIGH_NTase1; cl17673 508765003620 phosphotransacetylase; Reviewed; Region: eutD; PRK09653 508765003621 acetate kinase A/propionate kinase 2; Reviewed; Region: PRK00180 508765003622 propionate/acetate kinase; Provisional; Region: PRK12379 508765003623 Uncharacterized ACR, COG1399; Region: DUF177; pfam02620 508765003624 50S ribosomal protein L32; Reviewed; Region: rpmF; PRK12286 508765003625 putative phosphate acyltransferase; Provisional; Region: PRK05331 508765003626 acyl carrier protein; Provisional; Region: acpP; PRK00982 508765003627 ribonuclease III, bacterial; Region: RNaseIII; TIGR02191 508765003628 RIBOc. Ribonuclease III C terminal domain. This group consists of eukaryotic, bacterial and archeal ribonuclease III (RNAse III) proteins. RNAse III is a double stranded RNA-specific endonuclease. Prokaryotic RNAse III is important in...; Region: RIBOc; cd00593 508765003629 dimerization interface [polypeptide binding]; other site 508765003630 active site 508765003631 metal binding site [ion binding]; metal-binding site 508765003632 Double-stranded RNA binding motif. Binding is not sequence specific but is highly specific for double stranded RNA. Found in a variety of proteins including dsRNA dependent protein kinase PKR, RNA helicases, Drosophila staufen protein, E. coli RNase III; Region: DSRM; cd00048 508765003633 dsRNA binding site [nucleotide binding]; other site 508765003634 Elongator protein 3, MiaB family, Radical SAM; Region: Elp3; smart00729 508765003635 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 508765003636 FeS/SAM binding site; other site 508765003637 chromosome segregation protein SMC, common bacterial type; Region: SMC_prok_B; TIGR02168 508765003638 ATP-binding cassette domain of barmotin, a member of the SMC protein family; Region: ABC_SMC_barmotin; cd03278 508765003639 Walker A/P-loop; other site 508765003640 ATP binding site [chemical binding]; other site 508765003641 SMC proteins Flexible Hinge Domain; Region: SMC_hinge; smart00968 508765003642 ATP-binding cassette domain of barmotin, a member of the SMC protein family; Region: ABC_SMC_barmotin; cd03278 508765003643 ABC transporter signature motif; other site 508765003644 Walker B; other site 508765003645 D-loop; other site 508765003646 H-loop/switch region; other site 508765003647 signal recognition particle-docking protein FtsY; Provisional; Region: PRK10416 508765003648 The signal recognition particle (SRP) mediates the transport to or across the plasma membrane in bacteria and the endoplasmic reticulum in eukaryotes. SRP recognizes N-terminal sighnal sequences of newly synthesized polypeptides at the ribosome. The...; Region: SRP; cd03115 508765003649 P loop; other site 508765003650 GTP binding site [chemical binding]; other site 508765003651 putative DNA-binding protein; Validated; Region: PRK00118 508765003652 Putative helix-turn-helix protein, YlxM / p13 like; Region: UPF0122; pfam04297 508765003653 signal recognition particle protein; Provisional; Region: PRK10867 508765003654 SRP54-type protein, helical bundle domain; Region: SRP54_N; smart00963 508765003655 The signal recognition particle (SRP) mediates the transport to or across the plasma membrane in bacteria and the endoplasmic reticulum in eukaryotes. SRP recognizes N-terminal sighnal sequences of newly synthesized polypeptides at the ribosome. The...; Region: SRP; cd03115 508765003656 P loop; other site 508765003657 GTP binding site [chemical binding]; other site 508765003658 Signal peptide binding domain; Region: SRP_SPB; pfam02978 508765003659 30S ribosomal protein S16; Reviewed; Region: rpsP; PRK00040 508765003660 Predicted RNA-binding protein (contains KH domain) [General function prediction only]; Region: COG1837 508765003661 hypothetical protein; Provisional; Region: PRK00468 508765003662 16S rRNA-processing protein RimM; Provisional; Region: rimM; PRK00122 508765003663 RimM N-terminal domain; Region: RimM; pfam01782 508765003664 tRNA (guanine-N(1)-)-methyltransferase; Reviewed; Region: trmD; PRK00026 508765003665 50S ribosomal protein L19; Provisional; Region: rplS; PRK05338 508765003666 GTPase YlqF; Reviewed; Region: rbgA; PRK09563 508765003667 Circularly permuted YlqF GTPase; Region: YlqF; cd01856 508765003668 GTP/Mg2+ binding site [chemical binding]; other site 508765003669 G4 box; other site 508765003670 G5 box; other site 508765003671 Rat sarcoma (Ras)-like superfamily of small guanosine triphosphatases (GTPases); Region: Ras_like_GTPase; cl17170 508765003672 G1 box; other site 508765003673 G1 box; other site 508765003674 GTP/Mg2+ binding site [chemical binding]; other site 508765003675 Switch I region; other site 508765003676 G2 box; other site 508765003677 G2 box; other site 508765003678 Switch I region; other site 508765003679 G3 box; other site 508765003680 G3 box; other site 508765003681 Switch II region; other site 508765003682 Switch II region; other site 508765003683 G4 box; other site 508765003684 bacterial Ribonuclease HII-like; Region: RNase_HII_bacteria_HII_like; cd07182 508765003685 RNA/DNA hybrid binding site [nucleotide binding]; other site 508765003686 active site 508765003687 hypothetical protein; Reviewed; Region: PRK12497 508765003688 Predicted ATPase with chaperone activity [Posttranslational modification, protein turnover, chaperones]; Region: COG0606 508765003689 Subunit ChlI of Mg-chelatase; Region: ChlI; pfam13541 508765003690 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 508765003691 Walker A motif; other site 508765003692 ATP binding site [chemical binding]; other site 508765003693 Walker B motif; other site 508765003694 arginine finger; other site 508765003695 Magnesium chelatase, subunit ChlI; Region: Mg_chelatase_2; pfam13335 508765003696 DNA protecting protein DprA; Region: dprA; TIGR00732 508765003697 DNA recombination-mediator protein A; Region: DNA_processg_A; pfam02481 508765003698 DNA topoisomerase I; Validated; Region: PRK05582 508765003699 TOPRIM_TopoIA_TopoI: The topoisomerase-primase (TORPIM) domain found in members of the type IA family of DNA topoisomerases (Topo IA) similar to Escherichia coli DNA topoisomerase I. Type IA DNA topoisomerases remove (relax) negative supercoils in the...; Region: TOPRIM_TopoIA_TopoI; cd03363 508765003700 active site 508765003701 interdomain interaction site; other site 508765003702 putative metal-binding site [ion binding]; other site 508765003703 nucleotide binding site [chemical binding]; other site 508765003704 DNA Topoisomerase, subtype IA; DNA-binding, ATP-binding and catalytic domain of bacterial DNA topoisomerases I and III, and eukaryotic DNA topoisomerase III and eubacterial and archael reverse gyrases. Topoisomerases clevage single or double stranded DNA...; Region: TOP1Ac; cd00186 508765003705 domain I; other site 508765003706 DNA binding groove [nucleotide binding] 508765003707 phosphate binding site [ion binding]; other site 508765003708 domain II; other site 508765003709 domain III; other site 508765003710 nucleotide binding site [chemical binding]; other site 508765003711 catalytic site [active] 508765003712 domain IV; other site 508765003713 Topoisomerase DNA binding C4 zinc finger; Region: zf-C4_Topoisom; pfam01396 508765003714 Topoisomerase DNA binding C4 zinc finger; Region: zf-C4_Topoisom; pfam01396 508765003715 Topoisomerase DNA binding C4 zinc finger; Region: zf-C4_Topoisom; pfam01396 508765003716 transcriptional repressor CodY; Validated; Region: PRK04158 508765003717 CodY GAF-like domain; Region: CodY; pfam06018 508765003718 CodY helix-turn-helix domain; Region: HTH_CodY; pfam08222 508765003719 Ribosomal protein S2 (RPS2), involved in formation of the translation initiation complex, where it might contact the messenger RNA and several components of the ribosome. It has been shown that in Escherichia coli RPS2 is essential for the binding of...; Region: RPS2; cd01425 508765003720 rRNA interaction site [nucleotide binding]; other site 508765003721 S8 interaction site; other site 508765003722 putative laminin-1 binding site; other site 508765003723 elongation factor Ts; Provisional; Region: tsf; PRK09377 508765003724 UBA/TS-N domain; Region: UBA; pfam00627 508765003725 Elongation factor TS; Region: EF_TS; pfam00889 508765003726 Elongation factor TS; Region: EF_TS; pfam00889 508765003727 UMP kinase (UMPK)-Ec, the microbial/chloroplast uridine monophosphate kinase (uridylate kinase) enzyme that catalyzes UMP phosphorylation and plays a key role in pyrimidine nucleotide biosynthesis; regulation of this process is via feed-back control and...; Region: AAK_UMPK-PyrH-Ec; cd04254 508765003728 putative nucleotide binding site [chemical binding]; other site 508765003729 uridine monophosphate binding site [chemical binding]; other site 508765003730 homohexameric interface [polypeptide binding]; other site 508765003731 ribosome recycling factor; Reviewed; Region: frr; PRK00083 508765003732 Ribosome recycling factor (RRF). Ribosome recycling factor dissociates the posttermination complex, composed of the ribosome, deacylated tRNA, and mRNA, after termination of translation. Thus ribosomes are "recycled" and ready for another...; Region: RRF; cd00520 508765003733 hinge region; other site 508765003734 Cis (Z)-Isoprenyl Diphosphate Synthases (cis-IPPS); homodimers which catalyze the successive 1'-4 condensation of the isopentenyl diphosphate (IPP) molecule to trans,trans-farnesyl diphosphate (FPP) or to cis,trans-FPP to form long-chain polyprenyl...; Region: CIS_IPPS; cl00230 508765003735 Undecaprenyl pyrophosphate synthase [Lipid metabolism]; Region: UppS; COG0020 508765003736 catalytic residue [active] 508765003737 putative FPP diphosphate binding site; other site 508765003738 putative FPP binding hydrophobic cleft; other site 508765003739 dimer interface [polypeptide binding]; other site 508765003740 putative IPP diphosphate binding site; other site 508765003741 CDP-diglyceride synthetase [Lipid metabolism]; Region: CdsA; COG0575 508765003742 Cytidylyltransferase family; Region: CTP_transf_1; pfam01148 508765003743 Domain of unknown function DUF20; Region: UPF0118; pfam01594 508765003744 Predicted permease, member of the PurR regulon [General function prediction only]; Region: yhhT; cl00465 508765003745 1-deoxy-D-xylulose 5-phosphate reductoisomerase; Provisional; Region: PRK05447 508765003746 1-deoxy-D-xylulose 5-phosphate reductoisomerase; Region: DXP_reductoisom; pfam02670 508765003747 1-deoxy-D-xylulose 5-phosphate reductoisomerase C-terminal; Region: DXP_redisom_C; pfam08436 508765003748 DXP reductoisomerase C-terminal domain; Region: DXPR_C; pfam13288 508765003749 Predicted membrane-associated Zn-dependent proteases 1 [Cell envelope biogenesis, outer membrane]; Region: COG0750 508765003750 RseP-like Site-2 proteases (S2P), zinc metalloproteases (MEROPS family M50A), cleave transmembrane domains of substrate proteins, regulating intramembrane proteolysis (RIP) of diverse signal transduction mechanisms. In Escherichia coli, the S2P homolog...; Region: S2P-M50_PDZ_RseP-like; cd06163 508765003751 active site 508765003752 PDZ domain of bacterial and plant zinc metalloprotases, presumably membrane-associated or integral membrane proteases, which may be involved in signalling and regulatory mechanisms. May be responsible for substrate recognition and/or binding, as most PDZ...; Region: PDZ_metalloprotease; cd00989 508765003753 protein binding site [polypeptide binding]; other site 508765003754 RseP-like Site-2 proteases (S2P), zinc metalloproteases (MEROPS family M50A), cleave transmembrane domains of substrate proteins, regulating intramembrane proteolysis (RIP) of diverse signal transduction mechanisms. In Escherichia coli, the S2P homolog...; Region: S2P-M50_PDZ_RseP-like; cd06163 508765003755 putative substrate binding region [chemical binding]; other site 508765003756 4-hydroxy-3-methylbut-2-en-1-yl diphosphate synthase; Reviewed; Region: ispG; PRK00366 508765003757 4-hydroxy-3-methylbut-2-en-1-yl diphosphate synthase; Validated; Region: PRK00694 508765003758 4-hydroxy-3-methylbut-2-en-1-yl diphosphate synthase; Validated; Region: PRK00694 508765003759 DNA polymerase III PolC; Validated; Region: polC; PRK00448 508765003760 DNA polymerase III polC-type N-terminus; Region: DNA_pol3_alph_N; pfam11490 508765003761 polC_OBF: A subfamily of OB folds corresponding to the N-terminal OB-fold nucleic acid binding domain of Bacillus subtilis type C replicative DNA polymerase III alpha subunit (polC). Replication in B. subtilis and Staphylococcus aureus requires two...; Region: polC_OBF; cd04484 508765003762 generic binding surface II; other site 508765003763 generic binding surface I; other site 508765003764 Polymerase and Histidinol Phosphatase domain; Region: PHP; cl17102 508765003765 active site 508765003766 DEDDh 3'-5' exonuclease domain family; Region: DEDDh; cd06127 508765003767 active site 508765003768 catalytic site [active] 508765003769 substrate binding site [chemical binding]; other site 508765003770 Polymerase and Histidinol Phosphatase domain of alpha-subunit of bacterial polymerase III at PolC gene; Region: PHP_PolIIIA_POLC; cd07435 508765003771 ribosome maturation protein RimP; Reviewed; Region: PRK00092 508765003772 Sm and related proteins; Region: Sm_like; cl00259 508765003773 Bacillus subtilis YxlS-like, C-terminal domain; Region: YlxS_C; cd01734 508765003774 putative oligomer interface [polypeptide binding]; other site 508765003775 putative RNA binding site [nucleotide binding]; other site 508765003776 transcription elongation factor NusA; Provisional; Region: nusA; PRK12327 508765003777 NusA N-terminal domain; Region: NusA_N; pfam08529 508765003778 S1_NusA: N-utilizing substance A protein (NusA), S1-like RNA-binding domain. S1-like RNA-binding domains are found in a wide variety of RNA-associated proteins. NusA is a transcription elongation factor containing an N-terminal catalytic domain and three...; Region: S1_NusA; cd04455 508765003779 RNA binding site [nucleotide binding]; other site 508765003780 homodimer interface [polypeptide binding]; other site 508765003781 NusA-like KH domain; Region: KH_5; pfam13184 508765003782 NusA_K homology RNA-binding domain (KH). NusA is an essential multifunctional transcription elongation factor that is universally conserved among prokaryotes and archaea. NusA anti-termination function plays an important role in the expression of...; Region: NusA_KH; cd02134 508765003783 G-X-X-G motif; other site 508765003784 Ylxr homologs; group of conserved hypothetical bacterial proteins of unknown function; structure revealed putative RNA binding cleft; proteins are encoded by an operon that includes other proteins involved in transcription and/or translation; Region: YlxR; cd00279 508765003785 putative RNA binding cleft [nucleotide binding]; other site 508765003786 ribosomal protein L7Ae family protein; Provisional; Region: PRK05583 508765003787 Translation initiation factor IF-2, N-terminal region; Region: IF2_N; pfam04760 508765003788 translation initiation factor IF-2; Region: IF-2; TIGR00487 508765003789 Translation initiation factor IF-2, N-terminal region; Region: IF2_N; pfam04760 508765003790 Initiation Factor 2 (IF2)/ eukaryotic Initiation Factor 5B (eIF5B) family; Region: IF2_eIF5B; cd01887 508765003791 G1 box; other site 508765003792 putative GEF interaction site [polypeptide binding]; other site 508765003793 GTP/Mg2+ binding site [chemical binding]; other site 508765003794 Switch I region; other site 508765003795 G2 box; other site 508765003796 G3 box; other site 508765003797 Switch II region; other site 508765003798 G4 box; other site 508765003799 G5 box; other site 508765003800 This family represents the domain II of bacterial Initiation Factor 2 (IF2) and its eukaryotic mitochondrial homologue mtIF2. IF2, the largest initiation factor is an essential GTP binding protein. In E. coli three natural forms of IF2 exist in the cell; Region: IF2_mtIF2_II; cd03702 508765003801 Translation-initiation factor 2; Region: IF-2; pfam11987 508765003802 mtIF2_IVc: this family represents the C2 subdomain of domain IV of mitochondrial translation initiation factor 2 (mtIF2) which adopts a beta-barrel fold displaying a high degree of structural similarity with domain II of the translation elongation factor...; Region: mtIF2_IVc; cd03692 508765003803 ribosome-binding factor A; Validated; Region: rbfA; PRK00521 508765003804 Exopolyphosphatase-related proteins [General function prediction only]; Region: COG0618 508765003805 DHH family; Region: DHH; pfam01368 508765003806 DHHA1 domain; Region: DHHA1; pfam02272 508765003807 tRNA pseudouridine synthase B; Provisional; Region: truB; PRK00130 508765003808 Pseudouridine synthase, Escherichia coli TruB like; Region: PseudoU_synth_EcTruB; cd02573 508765003809 RNA binding site [nucleotide binding]; other site 508765003810 active site 508765003811 bifunctional riboflavin kinase/FMN adenylyltransferase; Reviewed; Region: PRK05627 508765003812 FAD synthetase, N-terminal domain of the bifunctional enzyme; Region: FAD_synthetase_N; cd02064 508765003813 active site 508765003814 Riboflavin kinase; Region: Flavokinase; pfam01687 508765003815 Ribosomal protein S15 (prokaryotic)_S13 (eukaryotic) binds the central domain of 16S rRNA and is required for assembly of the small ribosomal subunit and for intersubunit association, thus representing a key element in the assembly of the whole ribosome; Region: Ribosomal_S15p_S13e; cd00353 508765003816 16S/18S rRNA binding site [nucleotide binding]; other site 508765003817 S13e-L30e interaction site [polypeptide binding]; other site 508765003818 25S rRNA binding site [nucleotide binding]; other site 508765003819 polynucleotide phosphorylase/polyadenylase; Provisional; Region: PRK11824 508765003820 Polyribonucleotide nucleotidyltransferase, repeat 1; Region: RNase_PH_PNPase_1; cd11363 508765003821 RNase E interface [polypeptide binding]; other site 508765003822 trimer interface [polypeptide binding]; other site 508765003823 Polyribonucleotide nucleotidyltransferase, RNA binding domain; Region: PNPase; pfam03726 508765003824 Polyribonucleotide nucleotidyltransferase, repeat 2; Region: RNase_PH_PNPase_2; cd11364 508765003825 RNase E interface [polypeptide binding]; other site 508765003826 trimer interface [polypeptide binding]; other site 508765003827 active site 508765003828 Polynucleotide phosphorylase (PNPase) K homology RNA-binding domain (KH). PNPase is a polyribonucleotide nucleotidyl transferase that degrades mRNA in prokaryotes and plant chloroplasts. The C-terminal region of PNPase contains domains homologous to...; Region: PNPase_KH; cd02393 508765003829 putative nucleic acid binding region [nucleotide binding]; other site 508765003830 G-X-X-G motif; other site 508765003831 S1_PNPase: Polynucleotide phosphorylase (PNPase), ), S1-like RNA-binding domain. PNPase is a polyribonucleotide nucleotidyl transferase that degrades mRNA. It is a trimeric multidomain protein. The C-terminus contains the S1 domain which binds ssRNA; Region: S1_PNPase; cd04472 508765003832 RNA binding site [nucleotide binding]; other site 508765003833 domain interface; other site 508765003834 Predicted Zn-dependent peptidases [General function prediction only]; Region: PqqL; COG0612 508765003835 Insulinase (Peptidase family M16); Region: Peptidase_M16; pfam00675 508765003836 Peptidase M16 inactive domain; Region: Peptidase_M16_C; pfam05193 508765003837 Protein implicated in RNA metabolism, contains PRC-barrel domain [General function prediction only]; Region: COG1873; cl17889 508765003838 aspartate kinase I; Reviewed; Region: PRK08210 508765003839 Amino Acid Kinases (AAK) superfamily, catalytic domain; present in such enzymes like N-acetylglutamate kinase (NAGK), carbamate kinase (CK), aspartokinase (AK), glutamate-5-kinase (G5K) and UMP kinase (UMPK). The AAK superfamily includes kinases that...; Region: AAK; cl00452 508765003840 nucleotide binding site [chemical binding]; other site 508765003841 substrate binding site [chemical binding]; other site 508765003842 ACT domains of the diaminopimelate-sensitive aspartokinase (AK) isoenzyme AKI; Region: ACT_AKi-DapG-BS_1; cd04914 508765003843 ACT domains are commonly involved in specifically binding an amino acid or other small ligand leading to regulation of the enzyme; Region: ACT; cl09141 508765003844 Caseinolytic protease (ClpP) is an ATP-dependent protease; Region: Clp_protease_like; cl15763 508765003845 Clp protease; Region: CLP_protease; pfam00574 508765003846 active site 508765003847 Domain of unknown function (DUF4117); Region: DUF4117; pfam13491 508765003848 DNA segregation ATPase FtsK/SpoIIIE and related proteins [Cell division and chromosome partitioning]; Region: FtsK; COG1674 508765003849 FtsK/SpoIIIE family; Region: FtsK_SpoIIIE; pfam01580 508765003850 Ftsk gamma domain; Region: Ftsk_gamma; pfam09397 508765003851 2-methylthioadenine synthetase [Translation, ribosomal structure and biogenesis]; Region: MiaB; COG0621 508765003852 Uncharacterized protein family UPF0004; Region: UPF0004; pfam00919 508765003853 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 508765003854 FeS/SAM binding site; other site 508765003855 CDP-alcohol phosphatidyltransferase; Region: CDP-OH_P_transf; cl00453 508765003856 recombinase A; Provisional; Region: recA; PRK09354 508765003857 RecA is a bacterial enzyme which has roles in homologous recombination, DNA repair, and the induction of the SOS response. RecA couples ATP hydrolysis to DNA strand exchange; Region: recA; cd00983 508765003858 hexamer interface [polypeptide binding]; other site 508765003859 Walker A motif; other site 508765003860 ATP binding site [chemical binding]; other site 508765003861 Walker B motif; other site 508765003862 phosphodiesterase; Provisional; Region: PRK12704 508765003863 ATP synthase B/B' CF(0); Region: ATP-synt_B; cl17192 508765003864 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 508765003865 Zn2+ binding site [ion binding]; other site 508765003866 Mg2+ binding site [ion binding]; other site 508765003867 Stage V sporulation protein S (SpoVS); Region: SpoVS; pfam04232 508765003868 Histidine-containing phosphocarrier protein (HPr)-like proteins. HPr is a central component of the bacterial phosphoenolpyruvate sugar phosphotransferase system (PTS). The PTS catalyses the phosphorylation of sugar substrates during their translocation...; Region: PTS-HPr_like; cd00367 508765003869 dimerization domain swap beta strand [polypeptide binding]; other site 508765003870 regulatory protein interface [polypeptide binding]; other site 508765003871 active site 508765003872 regulatory phosphorylation site [posttranslational modification]; other site 508765003873 Adenylosuccinate lyase [Nucleotide transport and metabolism]; Region: PurB; COG0015 508765003874 Adenylsuccinate lyase (ASL)_subgroup 2; Region: Adenylsuccinate_lyase_2; cd03302 508765003875 tetramer interface [polypeptide binding]; other site 508765003876 active site 508765003877 Putative amidase domain; Region: Amidase_6; pfam12671 508765003878 Suppression of tumorigenicity 7; Region: ST7; cd11557 508765003879 riboflavin biosynthesis protein RibD; Region: eubact_ribD; TIGR00326 508765003880 Riboflavin-specific deaminase. Riboflavin biosynthesis protein RibD (Diaminohydroxyphosphoribosylaminopyrimidine deaminase) catalyzes the deamination of 2,5-diamino-6-ribosylamino-4(3H)-pyrimidinone 5'-phosphate, which is an intermediate step in the...; Region: Riboflavin_deaminase-reductase; cd01284 508765003881 catalytic motif [active] 508765003882 Zn binding site [ion binding]; other site 508765003883 RibD C-terminal domain; Region: RibD_C; cl17279 508765003884 riboflavin synthase subunit alpha; Provisional; Region: PRK09289 508765003885 Lumazine binding domain; Region: Lum_binding; pfam00677 508765003886 Lumazine binding domain; Region: Lum_binding; pfam00677 508765003887 bifunctional 3,4-dihydroxy-2-butanone 4-phosphate synthase/GTP cyclohydrolase II protein; Provisional; Region: PRK09311 508765003888 3,4-dihydroxy-2-butanone 4-phosphate synthase; Region: DHBP_synthase; pfam00926 508765003889 GTP cyclohydrolase II (RibA). GTP cyclohydrolase II catalyzes the conversion of GTP to 2,5-diamino-6-ribosylamino-4(3H)-pyrimidinone 5' phosphate, formate, pyrophosphate (APy), and GMP in the biosynthetic pathway of riboflavin. Riboflavin is the...; Region: GTP_cyclohydro2; cd00641 508765003890 dimerization interface [polypeptide binding]; other site 508765003891 active site 508765003892 lumazine synthase (6,7-dimethyl-8-ribityllumazine synthase, LS), catalyzes the penultimate step in the biosynthesis of riboflavin (vitamin B2); type-I; Region: Lumazine_synthase-I; cd09209 508765003893 homopentamer interface [polypeptide binding]; other site 508765003894 active site 508765003895 Transcriptional regulators of sugar metabolism [Transcription / Carbohydrate transport and metabolism]; Region: GlpR; COG1349 508765003896 DeoR-like helix-turn-helix domain; Region: HTH_DeoR; pfam08220 508765003897 DeoR C terminal sensor domain; Region: DeoRC; pfam00455 508765003898 Alcohol dehydrogenase, class IV [Energy production and conversion]; Region: EutG; COG1454 508765003899 Iron-containing alcohol dehydrogenases-like; Region: Fe-ADH6; cd08194 508765003900 putative active site [active] 508765003901 metal binding site [ion binding]; metal-binding site 508765003902 Tagatose-1,6-bisphosphate (TBP) aldolase and related Type B Class II aldolases. TBP aldolase is a tetrameric class II aldolase that catalyzes the reversible condensation of dihydroxyacetone phosphate with glyceraldehyde 3-phsophate to produce tagatose 1; Region: TBP_aldolase_IIB; cd00947 508765003903 intersubunit interface [polypeptide binding]; other site 508765003904 active site 508765003905 zinc binding site [ion binding]; other site 508765003906 Na+ binding site [ion binding]; other site 508765003907 2-keto-3-deoxygluconate kinase (KdgK) phosphorylates 2-keto-3-deoxygluconate (KDG) to form 2-keto-3-deoxy-6-phosphogluconate (KDGP). KDG is the common intermediate product, that allows organisms to channel D-glucuronate and/or D-galacturinate into the...; Region: KdgK; cd01166 508765003908 Sugar kinases, ribokinase family [Carbohydrate transport and metabolism]; Region: RbsK; COG0524 508765003909 substrate binding site [chemical binding]; other site 508765003910 ATP binding site [chemical binding]; other site 508765003911 KduI/IolB family; Region: KduI; pfam04962 508765003912 Acetolactate synthase [Amino acid transport and metabolism]; Region: COG3962 508765003913 Pyrimidine (PYR) binding domain of POX and related proteins; Region: TPP_PYR_POX_like; cd07035 508765003914 PYR/PP interface [polypeptide binding]; other site 508765003915 dimer interface [polypeptide binding]; other site 508765003916 TPP binding site [chemical binding]; other site 508765003917 Thiamine pyrophosphate enzyme, central domain; Region: TPP_enzyme_M; pfam00205 508765003918 Thiamine pyrophosphate (TPP) family, IolD subfamily, TPP-binding module; composed of proteins similar to Rhizobium leguminosarum bv. viciae IolD. IolD plays an important role in myo-inositol catabolism; Region: TPP_IolD; cd02003 508765003919 TPP-binding site; other site 508765003920 Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673 508765003921 Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408 508765003922 Oxidoreductase family, C-terminal alpha/beta domain; Region: GFO_IDH_MocA_C; pfam02894 508765003923 Sugar phosphate isomerases/epimerases [Carbohydrate transport and metabolism]; Region: IolE; COG1082 508765003924 Domain of unknown function (DUF3859); Region: DUF3859; pfam12975 508765003925 AP endonuclease family 2 C terminus; Region: AP_endonuc_2_N; pfam07582 508765003926 putative transporter; Provisional; Region: PRK10484 508765003927 uncharacterized SLC5 subfamily, Escherichia coli YidK-like; solute binding domain; Region: SLC5sbd_YidK; cd10328 508765003928 Na binding site [ion binding]; other site 508765003929 Transcriptional regulators [Transcription]; Region: RpiR; COG1737 508765003930 Helix-turn-helix domain, rpiR family; Region: HTH_6; pfam01418 508765003931 RpiR-like protein. RpiR contains a SIS (Sugar ISomerase) domain, which is found in many phosphosugar isomerases and phosphosugar binding proteins. In E. coli, rpiR negatively regulates the expression of rpiB gene. Both rpiB and rpiA are ribose phosphate...; Region: SIS_RpiR; cd05013 508765003932 putative active site [active] 508765003933 gluconate kinase, FGGY type; Region: gntK_FGGY; TIGR01314 508765003934 Gluconate kinases; a subfamily of the FGGY family of carbohydrate kinases; Region: FGGY_GntK; cd07770 508765003935 N- and C-terminal domain interface [polypeptide binding]; other site 508765003936 active site 508765003937 catalytic site [active] 508765003938 metal binding site [ion binding]; metal-binding site 508765003939 carbohydrate binding site [chemical binding]; other site 508765003940 ATP binding site [chemical binding]; other site 508765003941 high-affinity gluconate transporter; Provisional; Region: PRK14984 508765003942 gluconate transporter; Region: gntP; TIGR00791 508765003943 6-phosphogluconate dehydrogenase-like protein; Reviewed; Region: PRK09599 508765003944 Predicted 6-phosphogluconate dehydrogenase [Carbohydrate transport and metabolism]; Region: Gnd; COG1023 508765003945 ADP-ribose pyrophosphatase (ADPRase) catalyzes the hydrolysis of ADP-ribose and a variety of additional ADP-sugar conjugates to AMP and ribose-5-phosphate. Like other members of the Nudix hydrolase superfamily, it requires a divalent cation, such as Mg2+; Region: ADPRase_NUDT5; cd03424 508765003946 dimer interface [polypeptide binding]; other site 508765003947 ADP-ribose binding site [chemical binding]; other site 508765003948 active site 508765003949 nudix motif; other site 508765003950 metal binding site [ion binding]; metal-binding site 508765003951 Xanthine/uracil/vitamin C permease [Nucleotide transport and metabolism]; Region: COG2252 508765003952 T-box leader 508765003953 Glycerol dehydrogenase-like; Region: GlyDH-like2; cd08171 508765003954 Glycerol dehydrogenase and related enzymes [Energy production and conversion]; Region: GldA; COG0371 508765003955 putative active site [active] 508765003956 metal binding site [ion binding]; metal-binding site 508765003957 putative sporulation protein YtaF; Region: spore_YtaF; TIGR02840 508765003958 2-isopropylmalate synthase; Validated; Region: PRK03739 508765003959 Mycobacterium tuberculosis LeuA3 and related proteins, N-terminal catalytic TIM barrel domain; Region: DRE_TIM_LeuA; cd07942 508765003960 active site 508765003961 catalytic residues [active] 508765003962 metal binding site [ion binding]; metal-binding site 508765003963 LeuA allosteric (dimerisation) domain; Region: LeuA_dimer; smart00917 508765003964 phosphodiesterase YaeI; Provisional; Region: PRK11340 508765003965 Bacillus subtilis YkuE and related proteins, C-terminal metallophosphatase domain; Region: MPP_YkuE_C; cd07385 508765003966 putative active site [active] 508765003967 putative metal binding site [ion binding]; other site 508765003968 Leucine Rich repeats (2 copies); Region: LRR_4; pfam12799 508765003969 glucan-binding repeat; Region: glucan_65_rpt; TIGR04035 508765003970 glucan-binding repeat; Region: glucan_65_rpt; TIGR04035 508765003971 Cellulase M and related proteins [Carbohydrate transport and metabolism]; Region: FrvX; COG1363 508765003972 M42 Peptidase, Endoglucanase-like subfamily; Region: M42_glucanase_like; cd05657 508765003973 putative oligomer interface [polypeptide binding]; other site 508765003974 putative active site [active] 508765003975 metal binding site [ion binding]; metal-binding site 508765003976 mycofactocin radical SAM maturase; Region: mycofact_rSAM; TIGR03962 508765003977 Na+-driven multidrug efflux pump [Defense mechanisms]; Region: NorM; COG0534 508765003978 Uncharacterized subfamily of the multidrug and toxic compound extrusion (MATE) proteins; Region: MATE_like_1; cd13140 508765003979 Putative GTPases (G3E family) [General function prediction only]; Region: COG0523 508765003980 CobW/HypB/UreG, nucleotide-binding domain; Region: cobW; pfam02492 508765003981 Putative GTPases (G3E family) [General function prediction only]; Region: COG0523 508765003982 The Fer4_NifH superfamily contains a variety of proteins which share a common ATP-binding domain. Functionally, proteins in this superfamily use the energy from hydrolysis of NTP to transfer electron or ion; Region: Fer4_NifH; cl17203 508765003983 Predicted permeases [General function prediction only]; Region: COG0701 508765003984 Hemerythrin; Region: Hemerythrin; cd12107 508765003985 Fe binding site [ion binding]; other site 508765003986 Permeases of the drug/metabolite transporter (DMT) superfamily [Carbohydrate transport and metabolism / Amino acid transport and metabolism / General function prediction only]; Region: RhaT; COG0697 508765003987 EamA-like transporter family; Region: EamA; pfam00892 508765003988 helicase 45; Provisional; Region: PTZ00424 508765003989 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cl17251 508765003990 ATP binding site [chemical binding]; other site 508765003991 putative Mg++ binding site [ion binding]; other site 508765003992 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 508765003993 nucleotide binding region [chemical binding]; other site 508765003994 ATP-binding site [chemical binding]; other site 508765003995 ATP-dependent RNA helicase DbpA; Provisional; Region: PRK11776 508765003996 DEAD-box helicases. A diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker B motif; Region: DEADc; cd00268 508765003997 ATP binding site [chemical binding]; other site 508765003998 Mg++ binding site [ion binding]; other site 508765003999 motif III; other site 508765004000 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 508765004001 nucleotide binding region [chemical binding]; other site 508765004002 ATP-binding site [chemical binding]; other site 508765004003 RNA recognition motif in Bacillus subtilis ATP-dependent RNA helicase YxiN and similar proteins; Region: RRM_BsYxiN_like; cd12500 508765004004 RNA binding site [nucleotide binding]; other site 508765004005 methionine aminopeptidase; Provisional; Region: PRK12318 508765004006 SEC-C motif; Region: SEC-C; pfam02810 508765004007 Methionine Aminopeptidase 1. E.C. 3.4.11.18. Also known as methionyl aminopeptidase and Peptidase M. Catalyzes release of N-terminal amino acids, preferentially methionine, from peptides and arylamides; Region: MetAP1; cd01086 508765004008 active site 508765004009 MTH538 TIR-like domain (DUF1863); Region: DUF1863; pfam08937 508765004010 TIR domain; Region: TIR_2; pfam13676 508765004011 Thymidylate kinase [Nucleotide transport and metabolism]; Region: Tmk; COG0125 508765004012 Nucleoside/nucleotide kinase (NK) is a protein superfamily consisting of multiple families of enzymes that share structural similarity and are functionally related to the catalysis of the reversible phosphate group transfer from nucleoside triphosphates...; Region: NK; cl17190 508765004013 active site 508765004014 Thymidylate synthase and pyrimidine hydroxymethylase: Thymidylate synthase (TS) and deoxycytidylate hydroxymethylase (dCMP-HMase) are homologs that catalyze analogous alkylation of C5 of pyrimidine nucleotides. Both enzymes are involved in the...; Region: TS_Pyrimidine_HMase; cd00351 508765004015 active site 508765004016 dimerization interface [polypeptide binding]; other site 508765004017 MTH538 TIR-like domain (DUF1863); Region: DUF1863; pfam08937 508765004018 TIR domain; Region: TIR_2; cl17458 508765004019 Integrase core domain; Region: rve; pfam00665 508765004020 Transposase and inactivated derivatives, IS30 family [DNA replication, recombination, and repair]; Region: Tra8; COG2826 508765004021 TIR domain; Region: TIR_2; pfam13676 508765004022 Integrase core domain; Region: rve; pfam00665 508765004023 Transposase and inactivated derivatives, IS30 family [DNA replication, recombination, and repair]; Region: Tra8; COG2826 508765004024 The electron transfer flavoprotein (ETF) serves as a specific electron acceptor for various mitochondrial dehydrogenases. ETF transfers electrons to the main respiratory chain via ETF-ubiquinone oxidoreductase. ETF is an heterodimer that consists of an...; Region: ETF_beta; cd01714 508765004025 Ligand binding site [chemical binding]; other site 508765004026 Electron transfer flavoprotein domain; Region: ETF; pfam01012 508765004027 Electron transfer flavoprotein, alpha subunit [Energy production and conversion]; Region: FixB; COG2025 508765004028 The electron transfer flavoprotein (ETF) serves as a specific electron acceptor for various mitochondrial dehydrogenases. ETF transfers electrons to the main respiratory chain via ETF-ubiquinone oxidoreductase. ETF is an heterodimer that consists of an...; Region: ETF_alpha; cd01715 508765004029 Electron transfer flavoprotein FAD-binding domain; Region: ETF_alpha; pfam00766 508765004030 L-lactate permease [Energy production and conversion]; Region: LldP; COG1620 508765004031 L-lactate permease; Region: Lactate_perm; cl00701 508765004032 FAD/FMN-containing dehydrogenases [Energy production and conversion]; Region: GlcD; COG0277 508765004033 FAD binding domain; Region: FAD_binding_4; pfam01565 508765004034 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 508765004035 Short chain acyl-CoA dehydrogenases and eukaryotic short/branched chain acyl-CoA dehydrogenases; Region: SCAD_SBCAD; cd01158 508765004036 FAD binding site [chemical binding]; other site 508765004037 homotetramer interface [polypeptide binding]; other site 508765004038 substrate binding pocket [chemical binding]; other site 508765004039 catalytic base [active] 508765004040 ATPase components of ABC transporters with duplicated ATPase domains [General function prediction only]; Region: Uup; COG0488 508765004041 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 508765004042 catalase/hydroperoxidase HPI(I); Provisional; Region: PRK15061 508765004043 N-terminal catalytic domain of catalase-peroxidases; Region: catalase_peroxidase_1; cd00649 508765004044 dimer interface [polypeptide binding]; other site 508765004045 active site 508765004046 heme binding site [chemical binding]; other site 508765004047 C-terminal non-catalytic domain of catalase-peroxidases; Region: catalase_peroxidase_2; cd08200 508765004048 Ferredoxin-dependent bilin reductase; Region: Fe_bilin_red; cl07930 508765004049 Dehydrogenases (flavoproteins) [Energy production and conversion]; Region: FixC; COG0644 508765004050 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450 508765004051 Dehydrogenases (flavoproteins) [Energy production and conversion]; Region: FixC; COG0644 508765004052 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 508765004053 MarR family; Region: MarR_2; pfam12802 508765004054 Transcriptional regulators [Transcription]; Region: MarR; COG1846 508765004055 ATPase components of ABC transporters with duplicated ATPase domains [General function prediction only]; Region: Uup; COG0488 508765004056 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 508765004057 Walker A/P-loop; other site 508765004058 ATP binding site [chemical binding]; other site 508765004059 Q-loop/lid; other site 508765004060 ABC transporter signature motif; other site 508765004061 Walker B; other site 508765004062 D-loop; other site 508765004063 H-loop/switch region; other site 508765004064 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 508765004065 PTS system mannose-specific transporter subunits IIAB; Provisional; Region: PRK15088 508765004066 PTS_IIA, PTS system, mannose/sorbose specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIA_man; cd00006 508765004067 active pocket/dimerization site; other site 508765004068 active site 508765004069 phosphorylation site [posttranslational modification] 508765004070 PTS_IIB, PTS system, Mannose/sorbose specific IIB subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIB_man; cd00001 508765004071 active site 508765004072 phosphorylation site [posttranslational modification] 508765004073 PTS system mannose-specific transporter subunit IIC; Provisional; Region: PRK15065 508765004074 Phosphotransferase system, mannose/fructose/N-acetylgalactosamine-specific component IID [Carbohydrate transport and metabolism]; Region: ManZ; COG3716 508765004075 Domain of unknown function (DUF956); Region: DUF956; pfam06115 508765004076 Early set domain associated with the catalytic domain of sugar utilizing enzymes at either the N or C terminus; Region: E_set; cl09101 508765004077 GH18 domain of Chitinase D (ChiD). ChiD, a chitinase found in Bacillus circulans, hydrolyzes the 1,4-beta-linkages of N-acetylglucosamine in chitin and chitodextrins. The domain architecture of ChiD includes a catalytic glycosyl hydrolase family 18; Region: GH18_chitinase_D-like; cd02871 508765004078 Glycosyl hydrolases family 18; Region: Glyco_hydro_18; pfam00704 508765004079 putative active site [active] 508765004080 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 508765004081 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 508765004082 active site 508765004083 phosphorylation site [posttranslational modification] 508765004084 intermolecular recognition site; other site 508765004085 dimerization interface [polypeptide binding]; other site 508765004086 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 508765004087 DNA binding site [nucleotide binding] 508765004088 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 508765004089 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 508765004090 ATP binding site [chemical binding]; other site 508765004091 Mg2+ binding site [ion binding]; other site 508765004092 G-X-G motif; other site 508765004093 MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704 508765004094 FtsX-like permease family; Region: FtsX; pfam02687 508765004095 ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136 508765004096 ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255 508765004097 Walker A/P-loop; other site 508765004098 ATP binding site [chemical binding]; other site 508765004099 Q-loop/lid; other site 508765004100 ABC transporter signature motif; other site 508765004101 Walker B; other site 508765004102 D-loop; other site 508765004103 H-loop/switch region; other site 508765004104 Beta-lactamase class C and other penicillin binding proteins [Defense mechanisms]; Region: AmpC; COG1680 508765004105 Beta-lactamase; Region: Beta-lactamase; pfam00144 508765004106 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 508765004107 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 508765004108 active site 508765004109 phosphorylation site [posttranslational modification] 508765004110 intermolecular recognition site; other site 508765004111 dimerization interface [polypeptide binding]; other site 508765004112 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 508765004113 DNA binding site [nucleotide binding] 508765004114 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 508765004115 dimerization interface [polypeptide binding]; other site 508765004116 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 508765004117 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 508765004118 dimer interface [polypeptide binding]; other site 508765004119 phosphorylation site [posttranslational modification] 508765004120 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 508765004121 ATP binding site [chemical binding]; other site 508765004122 Mg2+ binding site [ion binding]; other site 508765004123 G-X-G motif; other site 508765004124 Bacterial extracellular solute-binding protein; Region: SBP_bac_11; pfam13531 508765004125 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 508765004126 substrate binding pocket [chemical binding]; other site 508765004127 membrane-bound complex binding site; other site 508765004128 ABC-type sulfate transport system, permease component [Posttranslational modification, protein turnover, chaperones]; Region: CysU; COG0555 508765004129 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 508765004130 dimer interface [polypeptide binding]; other site 508765004131 conserved gate region; other site 508765004132 putative PBP binding loops; other site 508765004133 ABC-ATPase subunit interface; other site 508765004134 ABC-type spermidine/putrescine transport systems, ATPase components [Amino acid transport and metabolism]; Region: PotA; COG3842 508765004135 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 508765004136 Walker A/P-loop; other site 508765004137 ATP binding site [chemical binding]; other site 508765004138 Q-loop/lid; other site 508765004139 ABC transporter signature motif; other site 508765004140 Walker B; other site 508765004141 D-loop; other site 508765004142 H-loop/switch region; other site 508765004143 TOBE domain; Region: TOBE; cl01440 508765004144 Domain of unknown function (DUF364); Region: DUF364; pfam04016 508765004145 Uncharacterized conserved protein [Function unknown]; Region: COG0398 508765004146 SNARE associated Golgi protein; Region: SNARE_assoc; pfam09335 508765004147 Adenine deaminase [Nucleotide transport and metabolism]; Region: AdeC; COG1001 508765004148 Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281 508765004149 Adenine deaminase (AdeC) directly deaminates adenine to form hypoxanthine. This reaction is part of one of the adenine salvage pathways, as well as the degradation pathway. It is important for adenine utilization as a purine, as well as a nitrogen source...; Region: AdeC; cd01295 508765004150 active site 508765004151 Adenine deaminase C-terminal domain; Region: Adenine_deam_C; pfam13382 508765004152 asparagine synthetase B; Provisional; Region: asnB; PRK09431 508765004153 Glutamine amidotransferases class-II (GATase) asparagine synthase_B type. Asparagine synthetase B catalyses the ATP-dependent conversion of aspartate to asparagine. This enzyme is a homodimer, with each monomer composed of a glutaminase domain and a...; Region: AsnB; cd00712 508765004154 dimer interface [polypeptide binding]; other site 508765004155 active site 508765004156 The C-terminal domain of Asparagine Synthase B. This domain is always found associated n-terminal amidotransferase domain. Family members that contain this domain catalyse the conversion of aspartate to asparagine. Asparagine synthetase B catalyzes the...; Region: Asn_Synthase_B_C; cd01991 508765004157 Ligand Binding Site [chemical binding]; other site 508765004158 Molecular Tunnel; other site 508765004159 T-box leader 508765004160 Domain of unknown function (DUF4317); Region: DUF4317; pfam14199 508765004161 Putative SAM-dependent methyltransferase; Region: SAM_MT; cl17517 508765004162 Cupin superfamily (DUF985); Region: Cupin_5; pfam06172 508765004163 Gamma-aminobutyrate permease and related permeases [Amino acid transport and metabolism]; Region: AnsP; COG1113 508765004164 Aminoglycoside 3'-phosphotransferase (APH) and Choline Kinase (ChoK) family. The APH/ChoK family is part of a larger superfamily that includes the catalytic domains of other kinases, such as the typical serine/threonine/tyrosine protein kinases (PKs)...; Region: APH_ChoK_like; cl17270 508765004165 Phosphotransferase enzyme family; Region: APH; pfam01636 508765004166 active site 508765004167 substrate binding site [chemical binding]; other site 508765004168 ATP binding site [chemical binding]; other site 508765004169 ABC-type Fe3+-hydroxamate transport system, periplasmic component [Inorganic ion transport and metabolism]; Region: FepB; COG0614 508765004170 Periplasmic binding protein YvrC. These proteins are predicted to function as initial receptors in ABC transport of metal ions in eubacteria and archaea. They belong to the TroA superfamily of periplasmic metal binding proteins that share a distinct...; Region: YvrC; cd01143 508765004171 putative binding site residues; other site 508765004172 iron-hydroxamate transporter permease subunit; Provisional; Region: PRK10577 508765004173 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550 508765004174 ABC-ATPase subunit interface; other site 508765004175 dimer interface [polypeptide binding]; other site 508765004176 putative PBP binding regions; other site 508765004177 ABC-type cobalamin/Fe3+-siderophores transport systems, ATPase components [Inorganic ion transport and metabolism / Coenzyme metabolism]; Region: FepC; COG1120 508765004178 ATP-binding component of iron-siderophores, vitamin B12 and hemin transporters and related proteins; Region: ABC_Iron-Siderophores_B12_Hemin; cd03214 508765004179 Walker A/P-loop; other site 508765004180 ATP binding site [chemical binding]; other site 508765004181 Q-loop/lid; other site 508765004182 ABC transporter signature motif; other site 508765004183 Walker B; other site 508765004184 D-loop; other site 508765004185 H-loop/switch region; other site 508765004186 Predicted ATPases of PP-loop superfamily [General function prediction only]; Region: COG2102 508765004187 This is a subfamily of Adenine nucleotide alpha hydrolases superfamily.Adeninosine nucleotide alpha hydrolases superfamily includes N type ATP PPases and ATP sulphurylases. It forms a apha/beta/apha fold which binds to Adenosine group. This subfamily; Region: Alpha_ANH_like_IV; cd01994 508765004188 Ligand Binding Site [chemical binding]; other site 508765004189 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 508765004190 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 508765004191 active site 508765004192 phosphorylation site [posttranslational modification] 508765004193 intermolecular recognition site; other site 508765004194 dimerization interface [polypeptide binding]; other site 508765004195 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 508765004196 DNA binding site [nucleotide binding] 508765004197 ABC-type multidrug transport system, ATPase component [Defense mechanisms]; Region: CcmA; COG1131 508765004198 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 508765004199 Walker A/P-loop; other site 508765004200 ATP binding site [chemical binding]; other site 508765004201 Q-loop/lid; other site 508765004202 ABC transporter signature motif; other site 508765004203 Walker B; other site 508765004204 D-loop; other site 508765004205 H-loop/switch region; other site 508765004206 ABC-2 family transporter protein; Region: ABC2_membrane_4; pfam12730 508765004207 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 508765004208 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 508765004209 dimer interface [polypeptide binding]; other site 508765004210 phosphorylation site [posttranslational modification] 508765004211 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 508765004212 ATP binding site [chemical binding]; other site 508765004213 Mg2+ binding site [ion binding]; other site 508765004214 G-X-G motif; other site 508765004215 Dolichyl-phosphate-mannose-protein mannosyltransferase; Region: PMT_2; pfam13231 508765004216 helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347 508765004217 MarR family; Region: MarR; pfam01047 508765004218 Subfamily of the multidrug and toxic compound extrusion (MATE)-like proteins similar to Streptococcus aureus MepA; Region: MATE_MepA_like; cd13143 508765004219 multidrug efflux pump VmrA; Reviewed; Region: vmrA; PRK09575 508765004220 Fusaric acid resistance protein-like; Region: FUSC_2; pfam13515 508765004221 Uncharacterized conserved protein [Function unknown]; Region: COG0397 508765004222 hypothetical protein; Validated; Region: PRK00029 508765004223 Protein of unknown function (DUF2992); Region: DUF2992; pfam11208 508765004224 Thiamine transporter protein (Thia_YuaJ); Region: Thia_YuaJ; cl17491 508765004225 Putative transcription activator [Transcription]; Region: TenA; COG0819 508765004226 L-cysteine desulfidase [Amino acid transport and metabolism]; Region: COG3681 508765004227 DnaJ domain; Region: DnaJ; pfam00226 508765004228 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 508765004229 Major Facilitator Superfamily; Region: MFS_1; pfam07690 508765004230 putative substrate translocation pore; other site 508765004231 Major Facilitator Superfamily; Region: MFS_1; pfam07690 508765004232 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 508765004233 putative substrate translocation pore; other site 508765004234 sulfate ABC transporter, ATP-binding protein; Region: 3a0106s01; TIGR00968 508765004235 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 508765004236 Walker A/P-loop; other site 508765004237 ATP binding site [chemical binding]; other site 508765004238 Q-loop/lid; other site 508765004239 ABC transporter signature motif; other site 508765004240 Walker B; other site 508765004241 D-loop; other site 508765004242 H-loop/switch region; other site 508765004243 Cation transport ATPase [Inorganic ion transport and metabolism]; Region: MgtA; COG0474 508765004244 E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122 508765004245 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 508765004246 motif II; other site 508765004247 ykoK leader 508765004248 magnesium-transporting ATPase MgtA; Provisional; Region: PRK10517 508765004249 Cation transporter/ATPase, N-terminus; Region: Cation_ATPase_N; pfam00690 508765004250 E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122 508765004251 Putative hydrolase of sodium-potassium ATPase alpha subunit; Region: Hydrolase_like2; pfam13246 508765004252 haloacid dehalogenase-like hydrolase; Region: HAD; pfam12710 508765004253 Soluble P-type ATPase [General function prediction only]; Region: COG4087 508765004254 Cation transporting ATPase, C-terminus; Region: Cation_ATPase_C; pfam00689 508765004255 Metallo-beta-lactamase superfamily; Region: Lactamase_B; smart00849 508765004256 Protein of unknown function (DUF2752); Region: DUF2752; pfam10825 508765004257 Domain of unknown function (DUF4234); Region: DUF4234; pfam14018 508765004258 Domain of unknown function (DUF4234); Region: DUF4234; pfam14018 508765004259 Protein of unknown function (DUF2992); Region: DUF2992; pfam11208 508765004260 Gamma carbonic anhydrases (CA): Carbonic anhydrases are zinc-containing enzymes that catalyze the reversible hydration of carbon dioxide in a two-step mechanism, involving the nucleophilic attack of a zinc-bound hydroxide ion on carbon dioxide, followed...; Region: LbH_gamma_CA; cd00710 508765004261 Carbonic anhydrases/acetyltransferases, isoleucine patch superfamily [General function prediction only]; Region: PaaY; COG0663 508765004262 trimer interface [polypeptide binding]; other site 508765004263 active site 508765004264 xanthine permease; Region: pbuX; TIGR03173 508765004265 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 508765004266 Short chain acyl-CoA dehydrogenases and eukaryotic short/branched chain acyl-CoA dehydrogenases; Region: SCAD_SBCAD; cd01158 508765004267 FAD binding site [chemical binding]; other site 508765004268 homotetramer interface [polypeptide binding]; other site 508765004269 substrate binding pocket [chemical binding]; other site 508765004270 catalytic base [active] 508765004271 Electron transfer flavoprotein, alpha subunit [Energy production and conversion]; Region: FixB; COG2025 508765004272 Electron transfer flavoprotein FAD-binding domain; Region: ETF_alpha; pfam00766 508765004273 Rubredoxin [Energy production and conversion]; Region: COG1773 508765004274 Rubredoxin; nonheme iron binding domains containing a [Fe(SCys)4] center. Rubredoxins are small nonheme iron proteins. The iron atom is coordinated by four cysteine residues (Fe(S-Cys)4), but iron can also be replaced by cobalt, nickel or zinc. They are...; Region: rubredoxin; cd00730 508765004275 iron binding site [ion binding]; other site 508765004276 Uncharacterized flavoproteins [Energy production and conversion]; Region: FpaA; COG0426 508765004277 Metallo-beta-lactamase superfamily; Region: Lactamase_B; smart00849 508765004278 Flavodoxin-like fold; Region: Flavodoxin_2; cl00438 508765004279 inner membrane transporter YjeM; Provisional; Region: PRK15238 508765004280 Predicted transcriptional regulators [Transcription]; Region: SoxR; COG0789 508765004281 Helix-Turn-Helix DNA binding domain of the MerR-like transcription regulators YyaN and YraB; Region: HTH_YyaN; cd01109 508765004282 DNA binding residues [nucleotide binding] 508765004283 putative dimer interface [polypeptide binding]; other site 508765004284 1-deoxy-D-xylulose-5-phosphate synthase; Provisional; Region: PRK12315 508765004285 Thiamine pyrophosphate (TPP) family, DXS subfamily, TPP-binding module; 1-Deoxy-D-xylulose-5-phosphate synthase (DXS) is a regulatory enzyme of the mevalonate-independent pathway involved in terpenoid biosynthesis. Terpeniods are plant natural products...; Region: TPP_DXS; cd02007 508765004286 TPP-binding site; other site 508765004287 Pyrimidine (PYR) binding domain of 1-deoxy-D-xylulose-5-phosphate synthase (DXS), transketolase (TK), and related proteins; Region: TPP_PYR_DXS_TK_like; cd07033 508765004288 PYR/PP interface [polypeptide binding]; other site 508765004289 dimer interface [polypeptide binding]; other site 508765004290 TPP binding site [chemical binding]; other site 508765004291 Transketolase, C-terminal domain; Region: Transketolase_C; pfam02780 508765004292 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 508765004293 haloacid dehalogenase-like hydrolase; Region: Hydrolase_3; pfam08282 508765004294 active site 508765004295 motif I; other site 508765004296 motif II; other site 508765004297 haloacid dehalogenase-like hydrolase; Region: HAD; cl17202 508765004298 M20 Peptidase Aminoacylase 1 family; Region: M20_Acy1; cd03886 508765004299 Metal-dependent amidase/aminoacylase/carboxypeptidase [General function prediction only]; Region: AbgB; COG1473 508765004300 metal binding site [ion binding]; metal-binding site 508765004301 dimer interface [polypeptide binding]; other site 508765004302 A subgroup of the Glycosyl hydrolase family 20 (GH20) catalytic domain found in proteins similar to the N-acetylhexosaminidase from Streptomyces plicatus (SpHex). SpHex catalyzes the hydrolysis of N-acetyl-beta-hexosaminides. An Asp residue within the...; Region: GH20_SpHex_like; cd06568 508765004303 Glycosyl hydrolase family 20, catalytic domain; Region: Glyco_hydro_20; pfam00728 508765004304 active site 508765004305 Alcohol dehydrogenase, class IV [Energy production and conversion]; Region: EutG; COG1454 508765004306 1,3-propanediol dehydrogenase (PPD) catalyzes the reduction of 3-hydroxypropionaldehyde (3-HPA) to 1,3-propanediol in glycerol metabolism; Region: PDD; cd08180 508765004307 putative active site [active] 508765004308 metal binding site [ion binding]; metal-binding site 508765004309 Helix-Turn-Helix DNA binding domain of the BmrR transcription regulator; Region: HTH_BmrR; cd01107 508765004310 Predicted transcriptional regulators [Transcription]; Region: SoxR; COG0789 508765004311 DNA binding residues [nucleotide binding] 508765004312 drug binding residues [chemical binding]; other site 508765004313 dimer interface [polypeptide binding]; other site 508765004314 GyrI-like small molecule binding domain; Region: GyrI-like; cl01368 508765004315 Multidrug resistance efflux transporter; Region: EmrE; pfam13536 508765004316 Transcriptional regulator PadR-like family; Region: PadR; cl17335 508765004317 Carbon dioxide concentrating mechanism/carboxysome shell protein [Secondary metabolites biosynthesis, transport, and catabolism / Energy production and conversion]; Region: CcmK; COG4577 508765004318 Carbon dioxide concentrating mechanism K (CcmK)-like proteins, Bacterial Micro-Compartment (BMC) domain; Region: BMC_CcmK_like; cd07045 508765004319 Hexamer interface [polypeptide binding]; other site 508765004320 Hexagonal pore residue; other site 508765004321 Coenzyme A acylating aldehyde dehydrogenase (ACDH), ALDH family 20-like; Region: ALDH_F20_ACDH; cd07122 508765004322 putative catalytic cysteine [active] 508765004323 glycyl radical enzyme, PFL2/glycerol dehydratase family; Region: PFL2-3; TIGR01774 508765004324 Pyruvate formate lyase 2 and related enzymes; Region: PFL2_DhaB_BssA; cd01677 508765004325 dimer interface [polypeptide binding]; other site 508765004326 active site 508765004327 glycine loop; other site 508765004328 glycyl-radical enzyme activating protein family; Region: PFLE_PFLC; TIGR02494 508765004329 RPB11 and RPB3 subunits of RNA polymerase; Region: RNAP_RPB11_RPB3; cl11409 508765004330 1,2-propanediol utilization protein U (PduU)/ethanolamine utilization protein S (EutS), Bacterial Micro-Compartment (BMC) domain; Region: BMC_PduU-EutS; cd07046 508765004331 putative hexamer interface [polypeptide binding]; other site 508765004332 putative hexagonal pore; other site 508765004333 Rat sarcoma (Ras)-like superfamily of small guanosine triphosphatases (GTPases); Region: Ras_like_GTPase; cd00882 508765004334 G1 box; other site 508765004335 GTP/Mg2+ binding site [chemical binding]; other site 508765004336 Switch I region; other site 508765004337 G3 box; other site 508765004338 Switch II region; other site 508765004339 G4 box; other site 508765004340 G5 box; other site 508765004341 Cobalamin adenosyltransferase; Region: Cob_adeno_trans; cl00920 508765004342 ethanolamine utilization protein EutJ; Provisional; Region: PRK15080 508765004343 Cell division protein FtsA; Region: FtsA; cl17206 508765004344 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cl17037 508765004345 nucleotide binding site [chemical binding]; other site 508765004346 Bacterial Micro-Compartment (BMC) domain; Region: BMC; cl01982 508765004347 Hexamer interface [polypeptide binding]; other site 508765004348 Hexagonal pore residue; other site 508765004349 Ethanolamine utilisation protein and carboxysome structural protein domain family; Region: EutN_CcmL; cd01614 508765004350 Hexamer/Pentamer interface [polypeptide binding]; other site 508765004351 central pore; other site 508765004352 Respiratory-chain NADH dehydrogenase 51 Kd subunit; Region: Complex1_51K; pfam01512 508765004353 SLBB domain; Region: SLBB; pfam10531 508765004354 4Fe-4S dicluster domain; Region: Fer4_17; pfam13534 508765004355 RnfC Barrel sandwich hybrid domain; Region: RnfC_N; pfam13375 508765004356 PduT-like ethanolamine utilization protein; Region: eut_PduT; TIGR02526 508765004357 1,2-propanediol utilization protein T (PduT), Bacterial Micro-Compartment (BMC) domain repeat 1; Region: BMC_PduT_repeat1; cd07053 508765004358 putative hexamer interface [polypeptide binding]; other site 508765004359 putative hexagonal pore; other site 508765004360 1,2-propanediol utilization protein T (PduT), Bacterial Micro-Compartment (BMC) domain repeat 2; Region: BMC_PduT_repeat2; cd07054 508765004361 putative hexamer interface [polypeptide binding]; other site 508765004362 putative hexagonal pore; other site 508765004363 ethanolamine utilization protein EutQ; Provisional; Region: PRK15457 508765004364 Ethanolamine utilisation protein EutQ; Region: EutQ; pfam06249 508765004365 Carbon dioxide concentrating mechanism/carboxysome shell protein [Secondary metabolites biosynthesis, transport, and catabolism / Energy production and conversion]; Region: CcmK; COG4577 508765004366 Carbon dioxide concentrating mechanism K (CcmK)-like proteins, Bacterial Micro-Compartment (BMC) domain; Region: BMC_CcmK_like; cd07045 508765004367 Hexamer interface [polypeptide binding]; other site 508765004368 Hexagonal pore residue; other site 508765004369 NAD-dependent aldehyde dehydrogenases [Energy production and conversion]; Region: PutA; COG1012 508765004370 Coenzyme A acylating aldehyde dehydrogenase (ACDH), ALDH family 20-like; Region: ALDH_F20_ACDH; cd07122 508765004371 putative catalytic cysteine [active] 508765004372 propanediol utilization phosphotransacylase; Provisional; Region: PRK15070 508765004373 Propanediol utilisation protein PduL; Region: PduL; pfam06130 508765004374 Ubiquitin-like proteins; Region: UBQ; cl00155 508765004375 charged pocket; other site 508765004376 Propanediol utilisation protein PduL; Region: PduL; pfam06130 508765004377 Carbon dioxide concentrating mechanism/carboxysome shell protein [Secondary metabolites biosynthesis, transport, and catabolism / Energy production and conversion]; Region: CcmK; COG4577 508765004378 1,2-propanediol utilization protein A (PduA), Bacterial Micro-Compartment (BMC) domain; Region: BMC_PduA; cd07059 508765004379 Hexamer interface [polypeptide binding]; other site 508765004380 Putative hexagonal pore residue; other site 508765004381 Hemerythrin; Region: Hemerythrin; cd12107 508765004382 Fe binding site [ion binding]; other site 508765004383 Xanthine/uracil/vitamin C permease [Nucleotide transport and metabolism]; Region: COG2252 508765004384 The Fer4_NifH superfamily contains a variety of proteins which share a common ATP-binding domain. Functionally, proteins in this superfamily use the energy from hydrolysis of NTP to transfer electron or ion; Region: Fer4_NifH; cl17203 508765004385 4Fe-4S dicluster domain; Region: Fer4_7; pfam12838 508765004386 4Fe-4S binding domain; Region: Fer4; pfam00037 508765004387 NADPH-dependent glutamate synthase beta chain and related oxidoreductases [Amino acid transport and metabolism / General function prediction only]; Region: GltD; COG0493 508765004388 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450 508765004389 4Fe-4S binding domain; Region: Fer4; pfam00037 508765004390 Zn finger protein HypA/HybF (possibly regulating hydrogenase expression) [General function prediction only]; Region: HybF; COG0375 508765004391 Hydrogenase expression/synthesis hypA family; Region: HypA; pfam01155 508765004392 Adenylate kinase, active site lid; Region: ADK_lid; pfam05191 508765004393 proposed F420-0 ABC transporter, periplasmic F420-0 binding protein; Region: F420-O_ABCperi; TIGR03868 508765004394 Helical backbone metal receptor (TroA-like domain). These proteins have been shown to function in the ABC transport of ferric siderophores and metal ions such as Mn2+, Fe3+, Cu2+ and/or Zn2+. Their ligand binding site is formed in the interface between...; Region: TroA-like; cl00262 508765004395 intersubunit interface [polypeptide binding]; other site 508765004396 ABC-type enterobactin transport system, permease component [Inorganic ion transport and metabolism]; Region: FepG; COG4779 508765004397 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550 508765004398 ABC-ATPase subunit interface; other site 508765004399 dimer interface [polypeptide binding]; other site 508765004400 putative PBP binding regions; other site 508765004401 ABC-type cobalamin/Fe3+-siderophores transport systems, ATPase components [Inorganic ion transport and metabolism / Coenzyme metabolism]; Region: FepC; COG1120 508765004402 ATP-binding component of iron-siderophores, vitamin B12 and hemin transporters and related proteins; Region: ABC_Iron-Siderophores_B12_Hemin; cd03214 508765004403 Walker A/P-loop; other site 508765004404 ATP binding site [chemical binding]; other site 508765004405 Q-loop/lid; other site 508765004406 ABC transporter signature motif; other site 508765004407 Walker B; other site 508765004408 D-loop; other site 508765004409 H-loop/switch region; other site 508765004410 Protein of unknown function (DUF2920); Region: DUF2920; pfam11144 508765004411 DEAD-like helicases superfamily; Region: DEXDc; smart00487 508765004412 DEAD-box helicases. A diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker B motif; Region: DEADc; cd00268 508765004413 ATP binding site [chemical binding]; other site 508765004414 Mg++ binding site [ion binding]; other site 508765004415 motif III; other site 508765004416 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 508765004417 nucleotide binding region [chemical binding]; other site 508765004418 ATP-binding site [chemical binding]; other site 508765004419 Probable zinc-binding domain; Region: zf-trcl; pfam13451 508765004420 Short C-terminal domain; Region: SHOCT; pfam09851 508765004421 D-alanyl-D-alanine carboxypeptidase [Cell envelope biogenesis, outer membrane]; Region: VanY; COG1876 508765004422 D-alanyl-D-alanine carboxypeptidase; Region: VanY; pfam02557 508765004423 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 508765004424 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 508765004425 active site 508765004426 phosphorylation site [posttranslational modification] 508765004427 intermolecular recognition site; other site 508765004428 dimerization interface [polypeptide binding]; other site 508765004429 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 508765004430 DNA binding site [nucleotide binding] 508765004431 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 508765004432 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cl01054 508765004433 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 508765004434 dimer interface [polypeptide binding]; other site 508765004435 phosphorylation site [posttranslational modification] 508765004436 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 508765004437 ATP binding site [chemical binding]; other site 508765004438 Mg2+ binding site [ion binding]; other site 508765004439 G-X-G motif; other site 508765004440 Peptidase family M9 N-terminal; Region: Peptidase_M9_N; pfam08453 508765004441 Peptidase Gluzincin family (thermolysin-like proteinases, TLPs) includes peptidases M1, M2, M3, M4, M13, M32 and M36 (fungalysins); Region: GluZincin; cl14813 508765004442 polycystic kidney disease I (PKD) domain; similar to other cell-surface modules, with an IG-like fold; domain probably functions as a ligand binding site in protein-protein or protein-carbohydrate interactions; a single instance of the repeat is...; Region: PKD; cd00146 508765004443 Bacterial pre-peptidase C-terminal domain; Region: PPC; pfam04151 508765004444 Bacterial pre-peptidase C-terminal domain; Region: PPC; pfam04151 508765004445 Bacterial pre-peptidase C-terminal domain; Region: PPC; pfam04151 508765004446 Fucose 4-O-acetylase and related acetyltransferases [Carbohydrate transport and metabolism]; Region: NolL; COG3594 508765004447 Acyltransferase family; Region: Acyl_transf_3; pfam01757 508765004448 Predicted SAM-dependent methyltransferases [General function prediction only]; Region: COG1092 508765004449 Middle domain of the SAM-dependent methyltransferase RlmI and related proteins; Region: RlmI_M_like; cd11572 508765004450 putative RNA binding site [nucleotide binding]; other site 508765004451 Methyltransferase domain; Region: Methyltransf_26; pfam13659 508765004452 Subfamily of the multidrug and toxic compound extrusion (MATE)-like proteins similar to Bacillus subtilis yoeA; Region: MATE_yoeA_like; cd13138 508765004453 Na+-driven multidrug efflux pump [Defense mechanisms]; Region: NorM; COG0534 508765004454 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 508765004455 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 508765004456 active site 508765004457 phosphorylation site [posttranslational modification] 508765004458 intermolecular recognition site; other site 508765004459 dimerization interface [polypeptide binding]; other site 508765004460 PAS fold; Region: PAS_4; pfam08448 508765004461 PAS fold; Region: PAS_4; pfam08448 508765004462 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 508765004463 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 508765004464 metal binding site [ion binding]; metal-binding site 508765004465 active site 508765004466 I-site; other site 508765004467 EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2). The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948 508765004468 TraX protein; Region: TraX; cl05434 508765004469 cxxc_20_cxxc protein; Region: cxxc_20_cxxc; TIGR04104 508765004470 RelA- and SpoT-like ppGpp Synthetases and Hydrolases, catalytic domain; Region: Rel-Spo_like; cl11966 508765004471 metal binding triad [ion binding]; metal-binding site 508765004472 Alpha-galactosidases/6-phospho-beta-glucosidases, family 4 of glycosyl hydrolases [Carbohydrate transport and metabolism]; Region: CelF; COG1486 508765004473 Glycoside Hydrolases Family 4; Phospho-beta-glucosidase; Region: GH4_P_beta_glucosidase; cd05296 508765004474 NAD binding site [chemical binding]; other site 508765004475 sugar binding site [chemical binding]; other site 508765004476 divalent metal binding site [ion binding]; other site 508765004477 tetramer (dimer of dimers) interface [polypeptide binding]; other site 508765004478 dimer interface [polypeptide binding]; other site 508765004479 Transcriptional regulators containing an AAA-type ATPase domain and a DNA-binding domain [Transcription / Signal transduction mechanisms]; Region: PspF; COG1221 508765004480 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 508765004481 Walker A motif; other site 508765004482 ATP binding site [chemical binding]; other site 508765004483 Walker B motif; other site 508765004484 arginine finger; other site 508765004485 Transcriptional antiterminator [Transcription]; Region: COG3933 508765004486 PRD domain; Region: PRD; pfam00874 508765004487 PTS_IIA, PTS system, mannose/sorbose specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIA_man; cd00006 508765004488 active pocket/dimerization site; other site 508765004489 active site 508765004490 phosphorylation site [posttranslational modification] 508765004491 PRD domain; Region: PRD; pfam00874 508765004492 PTS_IIB_chitobiose_lichenan: subunit IIB of enzyme II (EII) of the N,N-diacetylchitobiose-specific and lichenan-specific phosphoenolpyruvate:carbohydrate phosphotransferase system (PTS). In these systems, EII is either a lichenan- or an N; Region: PTS_IIB_chitobiose_lichenan; cd05564 508765004493 active site 508765004494 P-loop; other site 508765004495 phosphorylation site [posttranslational modification] 508765004496 PTS_IIA, PTS system, lactose/cellobiose specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_lac; cd00215 508765004497 methionine cluster; other site 508765004498 active site 508765004499 phosphorylation site [posttranslational modification] 508765004500 metal binding site [ion binding]; metal-binding site 508765004501 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cd00012 508765004502 nucleotide binding site [chemical binding]; other site 508765004503 Uncharacterized conserved protein [Function unknown]; Region: COG3589 508765004504 Bacterial protein of unknown function (DUF871); Region: DUF871; pfam05913 508765004505 Phosphotransferase system cellobiose-specific component IIC [Carbohydrate transport and metabolism]; Region: CelB; COG1455 508765004506 cellobiose phosphotransferase system IIC component; Reviewed; Region: celD; PRK09592 508765004507 Uncharacterized BCR, YitT family COG1284; Region: DUF161; pfam02588 508765004508 Uncharacterized conserved protein [Function unknown]; Region: COG1284 508765004509 Uncharacterized BCR, YitT family COG1284; Region: DUF161; pfam02588 508765004510 Uncharacterized protein conserved in bacteria (DUF2179); Region: DUF2179; pfam10035 508765004511 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 508765004512 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 508765004513 active site 508765004514 phosphorylation site [posttranslational modification] 508765004515 intermolecular recognition site; other site 508765004516 dimerization interface [polypeptide binding]; other site 508765004517 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 508765004518 DNA binding site [nucleotide binding] 508765004519 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 508765004520 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 508765004521 dimerization interface [polypeptide binding]; other site 508765004522 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 508765004523 dimer interface [polypeptide binding]; other site 508765004524 phosphorylation site [posttranslational modification] 508765004525 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 508765004526 ATP binding site [chemical binding]; other site 508765004527 Mg2+ binding site [ion binding]; other site 508765004528 G-X-G motif; other site 508765004529 Glycosyl hydrolases related to GH101 family; Region: GHL; pfam11308 508765004530 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 508765004531 Major Facilitator Superfamily; Region: MFS_1; pfam07690 508765004532 putative substrate translocation pore; other site 508765004533 Cation transport ATPase [Inorganic ion transport and metabolism]; Region: MgtA; COG0474 508765004534 Cation transporter/ATPase, N-terminus; Region: Cation_ATPase_N; pfam00690 508765004535 E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122 508765004536 Putative hydrolase of sodium-potassium ATPase alpha subunit; Region: Hydrolase_like2; pfam13246 508765004537 haloacid dehalogenase-like hydrolase; Region: HAD; pfam12710 508765004538 Cation transporting ATPase, C-terminus; Region: Cation_ATPase_C; pfam00689 508765004539 Transcriptional regulators of sugar metabolism [Transcription / Carbohydrate transport and metabolism]; Region: GlpR; COG1349 508765004540 helix_turn_helix, Deoxyribose operon repressor; Region: HTH_DEOR; smart00420 508765004541 DeoR C terminal sensor domain; Region: DeoRC; pfam00455 508765004542 glycyl-radical enzyme activating protein family; Region: PFLE_PFLC; TIGR02494 508765004543 4Fe-4S binding domain; Region: Fer4_6; pfam12837 508765004544 glycyl radical enzyme, PFL2/glycerol dehydratase family; Region: PFL2-3; TIGR01774 508765004545 Pyruvate formate lyase 2 and related enzymes; Region: PFL2_DhaB_BssA; cd01677 508765004546 dimer interface [polypeptide binding]; other site 508765004547 active site 508765004548 glycine loop; other site 508765004549 Transaldolase-like fructose-6-phosphate aldolases (FSA) found in bacteria and archaea; Region: Transaldolase_FSA; cd00956 508765004550 active site 508765004551 intersubunit interactions; other site 508765004552 catalytic residue [active] 508765004553 Cold-Shock Protein (CSP) contains an S1-like cold-shock domain (CSD) that is found in eukaryotes, prokaryotes, and archaea. CSP's include the major cold-shock proteins CspA and CspB in bacteria and the eukaryotic gene regulatory factor Y-box...; Region: CSP_CDS; cd04458 508765004554 DNA-binding site [nucleotide binding]; DNA binding site 508765004555 RNA-binding motif; other site 508765004556 multidrug efflux pump VmrA; Reviewed; Region: vmrA; PRK09575 508765004557 Subfamily of the multidrug and toxic compound extrusion (MATE)-like proteins similar to Streptococcus aureus MepA; Region: MATE_MepA_like; cd13143 508765004558 PTS system, beta-glucoside-specific IIABC component; Region: PTS-II-ABC-beta; TIGR01995 508765004559 PTS_IIB, PTS system, glucose/sucrose specific IIB subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIB_glc; cd00212 508765004560 active site turn [active] 508765004561 phosphorylation site [posttranslational modification] 508765004562 Phosphotransferase system IIC components, glucose/maltose/N-acetylglucosamine-specific [Carbohydrate transport and metabolism]; Region: PtsG; COG1263 508765004563 Phosphotransferase system IIA components [Carbohydrate transport and metabolism]; Region: NagE; COG2190 508765004564 HPr interaction site; other site 508765004565 glycerol kinase (GK) interaction site [polypeptide binding]; other site 508765004566 active site 508765004567 phosphorylation site [posttranslational modification] 508765004568 Beta-glucosidase/6-phospho-beta-glucosidase/beta- galactosidase [Carbohydrate transport and metabolism]; Region: BglB; COG2723 508765004569 beta-galactosidase; Region: BGL; TIGR03356 508765004570 transcriptional antiterminator BglG; Provisional; Region: PRK09772 508765004571 CAT RNA binding domain; Region: CAT_RBD; smart01061 508765004572 PRD domain; Region: PRD; pfam00874 508765004573 PRD domain; Region: PRD; pfam00874 508765004574 hybrid cluster protein-associated redox disulfide domain; Region: prismane_assoc; TIGR03980 508765004575 Nitrite/Sulfite reductase ferredoxin-like half domain; Region: NIR_SIR_ferr; pfam03460 508765004576 Nitrite and sulphite reductase 4Fe-4S domain; Region: NIR_SIR; pfam01077 508765004577 Predicted xylanase/chitin deacetylase [Carbohydrate transport and metabolism]; Region: CDA1; COG0726 508765004578 Catalytic NodB homology domain of Streptococcus mutans polysaccharide deacetylase PgdA, Bacillus subtilis YheN, and similar proteins; Region: CE4_SmPgdA_like; cd10944 508765004579 NodB motif; other site 508765004580 active site 508765004581 catalytic site [active] 508765004582 Zn binding site [ion binding]; other site 508765004583 Sugar kinases, ribokinase family [Carbohydrate transport and metabolism]; Region: RbsK; COG0524 508765004584 Ribokinase catalyses the phosphorylation of ribose to ribose-5-phosphate using ATP. This reaction is the first step in the ribose metabolism. It traps ribose within the cell after uptake and also prepares the sugar for use in the synthesis of nucleotides...; Region: ribokinase; cd01174 508765004585 substrate binding site [chemical binding]; other site 508765004586 dimer interface [polypeptide binding]; other site 508765004587 ATP binding site [chemical binding]; other site 508765004588 D-ribose pyranase; Provisional; Region: PRK11797 508765004589 ABC-type sugar transport system, ATPase component [Carbohydrate transport and metabolism]; Region: MglA; COG1129 508765004590 First domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_I; cd03216 508765004591 Walker A/P-loop; other site 508765004592 ATP binding site [chemical binding]; other site 508765004593 Q-loop/lid; other site 508765004594 ABC transporter signature motif; other site 508765004595 Walker B; other site 508765004596 D-loop; other site 508765004597 H-loop/switch region; other site 508765004598 Second domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_II; cd03215 508765004599 Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653 508765004600 Transmembrane subunit (TM) of Escherichia coli AraH and related proteins. E. coli AraH is the TM of a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of the monosaccharide arabinose. This group...; Region: TM_PBP1_transp_AraH_like; cd06579 508765004601 TM-ABC transporter signature motif; other site 508765004602 D-ribose transporter subunit RbsB; Provisional; Region: PRK10653 508765004603 Periplasmic sugar-binding domain of the thermophilic Thermoanaerobacter tengcongensis ribose binding protein (ttRBP) and its mesophilic homologs; Region: PBP1_ribose_binding; cd06323 508765004604 ligand binding site [chemical binding]; other site 508765004605 dimerization interface [polypeptide binding]; other site 508765004606 Transcriptional regulators [Transcription]; Region: PurR; COG1609 508765004607 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 508765004608 DNA binding site [nucleotide binding] 508765004609 domain linker motif; other site 508765004610 Ligand binding domain of the LacI tanscriptional regulator family belonging to the type I periplasmic-binding fold protein superfamily; Region: PBP1_LacI_sugar_binding_like; cd06267 508765004611 dimerization interface [polypeptide binding]; other site 508765004612 ligand binding site [chemical binding]; other site 508765004613 GGCT-like domains, also called AIG2-like family. Gamma-glutamyl cyclotransferase (GGCT) catalyzes the formation of pyroglutamic acid (5-oxoproline) from dipeptides containing gamma-glutamyl, and is a dimeric protein. In Homo sapiens, the protein is...; Region: GGCT_like; cd06661 508765004614 putative active site pocket [active] 508765004615 dimerization interface [polypeptide binding]; other site 508765004616 putative catalytic residue [active] 508765004617 Pyroglutamyl peptidase (PGP) type I, also known as pyrrolidone carboxyl peptidase (pcp) type I: Enzymes responsible for cleaving pyroglutamate (pGlu) from the N-terminal end of specialized proteins. The N-terminal pGlu protects these proteins from...; Region: Peptidase_C15; cd00501 508765004618 putative substrate binding pocket [chemical binding]; other site 508765004619 AC domain interface; other site 508765004620 catalytic triad [active] 508765004621 AB domain interface; other site 508765004622 interchain disulfide; other site 508765004623 Predicted membrane protein [Function unknown]; Region: COG3817 508765004624 Protein of unknown function (DUF979); Region: DUF979; pfam06166 508765004625 Protein of unknown function (DUF969); Region: DUF969; pfam06149 508765004626 Arna decarboxylase_like, extended (e) SDRs; Region: Arna_like_SDR_e; cd05257 508765004627 NAD dependent epimerase/dehydratase, LLPSF_EDH_00030 family; Region: EDH_00030; TIGR04180 508765004628 NAD binding site [chemical binding]; other site 508765004629 substrate binding site [chemical binding]; other site 508765004630 active site 508765004631 aminotransferase, LLPSF_NHT_00031 family; Region: NHT_00031; TIGR04181 508765004632 3-amino-5-hydroxybenzoic acid synthase family (AHBA_syn). AHBA_syn family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The members of this CD are involved in various biosynthetic pathways for secondary...; Region: AHBA_syn; cd00616 508765004633 inhibitor-cofactor binding pocket; inhibition site 508765004634 pyridoxal 5'-phosphate binding site [chemical binding]; other site 508765004635 catalytic residue [active] 508765004636 CMP-NeuAc_Synthase activates N-acetylneuraminic acid by adding CMP moiety; Region: CMP-NeuAc_Synthase; cd02513 508765004637 ligand binding site; other site 508765004638 tetramer interface; other site 508765004639 Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321 508765004640 Acetyltransferase (GNAT) domain; Region: Acetyltransf_6; cl17497 508765004641 Peptidase associated domain: C-terminal domain of M14 N/E carboxypeptidase; putative folding, regulation, or interaction domain; Region: Peptidase_M14NE-CP-C_like; cl17499 508765004642 helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347 508765004643 MarR family; Region: MarR; pfam01047 508765004644 Flavodoxin-like fold; Region: Flavodoxin_2; pfam02525 508765004645 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2604 508765004646 Peptidase associated domain: C-terminal domain of M14 N/E carboxypeptidase; putative folding, regulation, or interaction domain; Region: Peptidase_M14NE-CP-C_like; cl17499 508765004647 The CBS domain, named after human CBS, is a small domain originally identified in cystathionine beta-synthase and is subsequently found in a wide range of different proteins. CBS domains usually occur in tandem repeats. They associate to form a so-called...; Region: CBS_pair; cl15354 508765004648 FOG: CBS domain [General function prediction only]; Region: COG0517 508765004649 NTP_trnasferase_like_2 is a member of the nucleotidyl transferase family; Region: NTP_transferase_like_2; cd06426 508765004650 Nucleoside-diphosphate-sugar pyrophosphorylase involved in lipopolysaccharide biosynthesis/translation initiation factor 2B, gamma/epsilon subunits (eIF-2Bgamma/eIF-2Bepsilon) [Cell envelope biogenesis, outer membrane / Translation, ribosomal structure...; Region: GCD1; COG1208 508765004651 Substrate binding site; other site 508765004652 metal-binding site 508765004653 Acetyltransferase (GNAT) domain; Region: Acetyltransf_3; pfam13302 508765004654 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 508765004655 Coenzyme A binding pocket [chemical binding]; other site 508765004656 UDP-N-acetyl-D-glucosamine 2-epimerase, UDP-hydrolysing; Region: NeuC_NnaA; TIGR03568 508765004657 Bacterial members of the UDP-N-Acetylglucosamine (GlcNAc) 2-Epimerase family are known to catalyze the reversible interconversion of UDP-GlcNAc and UDP-N-acetylmannosamine (UDP-ManNAc). The enzyme serves to produce an activated form of ManNAc residues; Region: GT1_UDP-GlcNAc_2-Epimerase; cd03786 508765004658 active site 508765004659 homodimer interface [polypeptide binding]; other site 508765004660 GlcNAc-PI de-N-acetylase; Region: PIG-L; pfam02585 508765004661 Acetyltransferase (GNAT) domain; Region: Acetyltransf_9; pfam13527 508765004662 A-macroglobulin receptor; Region: A2M_recep; pfam07677 508765004663 N-acetylneuraminate synthase; Region: NeuB_NnaB; TIGR03569 508765004664 NeuB family; Region: NeuB; pfam03102 508765004665 C-terminal SAF domain of sialic acid synthetase; Region: SAF_NeuB_like; cd11615 508765004666 NeuB binding interface [polypeptide binding]; other site 508765004667 putative substrate binding site [chemical binding]; other site 508765004668 Protein of unknown function, DUF606; Region: DUF606; pfam04657 508765004669 Protein of unknown function, DUF606; Region: DUF606; pfam04657 508765004670 Membrane protein of unknown function; Region: DUF360; pfam04020 508765004671 DNA-binding transcriptional activator YeiL; Provisional; Region: PRK10402 508765004672 effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038 508765004673 ligand binding site [chemical binding]; other site 508765004674 flexible hinge region; other site 508765004675 Crp-like helix-turn-helix domain; Region: HTH_Crp_2; pfam13545 508765004676 Ca2+/Na+ antiporter [Inorganic ion transport and metabolism]; Region: ECM27; COG0530 508765004677 Sodium/calcium exchanger protein; Region: Na_Ca_ex; pfam01699 508765004678 yybP-ykoY leader 508765004679 Elongator protein 3, MiaB family, Radical SAM; Region: Elp3; smart00729 508765004680 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 508765004681 FeS/SAM binding site; other site 508765004682 Chemotaxis signal transduction protein [Cell motility and secretion / Signal transduction mechanisms]; Region: CheW; COG0835 508765004683 FOG: CheY-like receiver [Signal transduction mechanisms]; Region: CheY; COG0784 508765004684 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 508765004685 active site 508765004686 phosphorylation site [posttranslational modification] 508765004687 intermolecular recognition site; other site 508765004688 dimerization interface [polypeptide binding]; other site 508765004689 Methyltransferase domain; Region: Methyltransf_31; pfam13847 508765004690 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 508765004691 S-adenosylmethionine binding site [chemical binding]; other site 508765004692 AraC-like ligand binding domain; Region: AraC_binding; pfam02311 508765004693 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 508765004694 Sodium:dicarboxylate symporter family; Region: SDF; pfam00375 508765004695 Na+/H+-dicarboxylate symporters [Energy production and conversion]; Region: GltP; COG1301 508765004696 Nucleotidyltransferase (NT) domain of RelA- and SpoT-like ppGpp synthetases and hydrolases; Region: NT_Rel-Spo_like; cd05399 508765004697 synthetase active site [active] 508765004698 NTP binding site [chemical binding]; other site 508765004699 metal binding site [ion binding]; metal-binding site 508765004700 3-hydroxyisobutyrate dehydrogenase and related beta-hydroxyacid dehydrogenases [Lipid metabolism]; Region: MmsB; COG2084 508765004701 6-phosphogluconate dehydrogenase-like protein; Reviewed; Region: PRK09599 508765004702 Cysteine synthase [Amino acid transport and metabolism]; Region: CysK; COG0031 508765004703 CBS_like: This subgroup includes Cystathionine beta-synthase (CBS) and Cysteine synthase. CBS is a unique heme-containing enzyme that catalyzes a pyridoxal 5'-phosphate (PLP)-dependent condensation of serine and homocysteine to give cystathionine; Region: CBS_like; cd01561 508765004704 dimer interface [polypeptide binding]; other site 508765004705 pyridoxal 5'-phosphate binding site [chemical binding]; other site 508765004706 catalytic residue [active] 508765004707 Putative peptidoglycan binding domain; Region: PG_binding_4; pfam12229 508765004708 Putative peptidoglycan binding domain; Region: PG_binding_4; pfam12229 508765004709 L,D-transpeptidase catalytic domain; Region: YkuD; pfam03734 508765004710 alanine racemase; Reviewed; Region: alr; PRK00053 508765004711 Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzyme Alanine Racemase; Region: PLPDE_III_AR; cd00430 508765004712 active site 508765004713 pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site 508765004714 dimer interface [polypeptide binding]; other site 508765004715 substrate binding site [chemical binding]; other site 508765004716 catalytic residues [active] 508765004717 Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain (MocR family) and their eukaryotic orthologs [Transcription / Amino acid transport and metabolism]; Region: ARO8; COG1167 508765004718 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 508765004719 DNA-binding site [nucleotide binding]; DNA binding site 508765004720 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 508765004721 pyridoxal 5'-phosphate binding site [chemical binding]; other site 508765004722 homodimer interface [polypeptide binding]; other site 508765004723 catalytic residue [active] 508765004724 Putative peptidoglycan binding domain; Region: PG_binding_4; pfam12229 508765004725 Putative peptidoglycan binding domain; Region: PG_binding_4; pfam12229 508765004726 L,D-transpeptidase catalytic domain; Region: YkuD; pfam03734 508765004727 Protein of unknown function (DUF503); Region: DUF503; pfam04456 508765004728 Predicted membrane protein [Function unknown]; Region: COG4129 508765004729 Bacterial protein of unknown function (DUF939); Region: DUF939; pfam06081 508765004730 DUF939 C-terminal domain; Region: DUF939_C; pfam11728 508765004731 Transcriptional regulators [Transcription]; Region: PhnF; COG2188 508765004732 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 508765004733 DNA-binding site [nucleotide binding]; DNA binding site 508765004734 Uridine phosphorylase [Nucleotide transport and metabolism]; Region: Udp; COG2820 508765004735 Phosphorylase superfamily; Region: PNP_UDP_1; cl00303 508765004736 Nucleoside permease [Nucleotide transport and metabolism]; Region: NupC; COG1972 508765004737 Na+ dependent nucleoside transporter N-terminus; Region: Nucleos_tra2_N; pfam01773 508765004738 Na+ dependent nucleoside transporter C-terminus; Region: Nucleos_tra2_C; pfam07662 508765004739 phosphopentomutase; Provisional; Region: PRK05362 508765004740 Metalloenzyme superfamily; Region: Metalloenzyme; pfam01676 508765004741 Thiamine pyrophosphate (TPP) family, Transketolase (TK) subfamily, TPP-binding module; TK catalyzes the transfer of a two-carbon unit from ketose phosphates to aldose phosphates. In heterotrophic organisms, TK provides a link between glycolysis and the...; Region: TPP_TK; cd02012 508765004742 transketolase; Reviewed; Region: PRK05899 508765004743 TPP-binding site [chemical binding]; other site 508765004744 dimer interface [polypeptide binding]; other site 508765004745 purine nucleoside phosphorylase; Reviewed; Region: deoD; PRK05819 508765004746 Uridine phosphorylase [Nucleotide transport and metabolism]; Region: Udp; COG2820 508765004747 Transaldolase-like fructose-6-phosphate aldolases (FSA) found in bacteria and archaea; Region: Transaldolase_FSA; cd00956 508765004748 active site 508765004749 intersubunit interactions; other site 508765004750 catalytic residue [active] 508765004751 Predicted membrane protein [Function unknown]; Region: COG1511 508765004752 YhgE/Pip N-terminal domain; Region: pip_yhgE_Nterm; TIGR03061 508765004753 YhgE/Pip C-terminal domain; Region: pip_yhgE_Cterm; TIGR03062 508765004754 Subfamily of the multidrug and toxic compound extrusion (MATE)-like proteins similar to Bacillus subtilis yoeA; Region: MATE_yoeA_like; cd13138 508765004755 Na+-driven multidrug efflux pump [Defense mechanisms]; Region: NorM; COG0534 508765004756 mRNA degradation ribonucleases J1/J2 (metallo-beta-lactamase superfamily) [Translation, ribosomal structure and biogenesis; Replication, recombination and repair]; Region: COG0595 508765004757 Metallo-beta-lactamase superfamily; Region: Lactamase_B; smart00849 508765004758 RNA-metabolising metallo-beta-lactamase; Region: RMMBL; pfam07521 508765004759 Rat sarcoma (Ras)-like superfamily of small guanosine triphosphatases (GTPases); Region: Ras_like_GTPase; cl17170 508765004760 Dynamin-like protein including dynamins, mitofusins, and guanylate-binding proteins; Region: DLP_2; cd09912 508765004761 Dynamin family; Region: Dynamin_N; pfam00350 508765004762 G1 box; other site 508765004763 G1 box; other site 508765004764 GTP/Mg2+ binding site [chemical binding]; other site 508765004765 GTP/Mg2+ binding site [chemical binding]; other site 508765004766 G2 box; other site 508765004767 Switch I region; other site 508765004768 G3 box; other site 508765004769 Switch II region; other site 508765004770 G4 box; other site 508765004771 G5 box; other site 508765004772 Dynamin family; Region: Dynamin_N; pfam00350 508765004773 Rat sarcoma (Ras)-like superfamily of small guanosine triphosphatases (GTPases); Region: Ras_like_GTPase; cl17170 508765004774 GTP/Mg2+ binding site [chemical binding]; other site 508765004775 G1 box; other site 508765004776 G2 box; other site 508765004777 Switch I region; other site 508765004778 G3 box; other site 508765004779 Switch II region; other site 508765004780 G4 box; other site 508765004781 Rat sarcoma (Ras)-like superfamily of small guanosine triphosphatases (GTPases); Region: Ras_like_GTPase; cl17170 508765004782 G1 box; other site 508765004783 GTP/Mg2+ binding site [chemical binding]; other site 508765004784 G2 box; other site 508765004785 Switch I region; other site 508765004786 G3 box; other site 508765004787 Switch II region; other site 508765004788 G4 box; other site 508765004789 Predicted pyridoxal phosphate-dependent enzyme apparently involved in regulation of cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WecE; COG0399 508765004790 3-amino-5-hydroxybenzoic acid synthase family (AHBA_syn). AHBA_syn family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The members of this CD are involved in various biosynthetic pathways for secondary...; Region: AHBA_syn; cd00616 508765004791 inhibitor-cofactor binding pocket; inhibition site 508765004792 pyridoxal 5'-phosphate binding site [chemical binding]; other site 508765004793 catalytic residue [active] 508765004794 Helix-Turn-Helix DNA binding domain of the transcription regulators TipAL, Mta, and SkgA; Region: HTH_TipAL-Mta; cd01106 508765004795 MerR HTH family regulatory protein; Region: MerR_1; pfam13411 508765004796 DNA binding residues [nucleotide binding] 508765004797 dimer interface [polypeptide binding]; other site 508765004798 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 508765004799 S-adenosylmethionine binding site [chemical binding]; other site 508765004800 DnaJ-class molecular chaperone with C-terminal Zn finger domain [Posttranslational modification, protein turnover, chaperones]; Region: DnaJ; COG0484 508765004801 DnaJ domain or J-domain. DnaJ/Hsp40 (heat shock protein 40) proteins are highly conserved and play crucial roles in protein translation, folding, unfolding, translocation, and degradation. They act primarily by stimulating the ATPase activity of Hsp70s; Region: DnaJ; cd06257 508765004802 HSP70 interaction site [polypeptide binding]; other site 508765004803 antheraxanthin epoxidase/zeaxanthin epoxidase; Region: PLN02927 508765004804 Forkhead associated domain (FHA); found in eukaryotic and prokaryotic proteins. Putative nuclear signalling domain. FHA domains may bind phosphothreonine, phosphoserine and sometimes phosphotyrosine. In eukaryotes, many FHA domain-containing proteins...; Region: FHA; cd00060 508765004805 phosphopeptide binding site; other site 508765004806 Serine/threonine phosphatases, family 2C, catalytic domain; The protein architecture and deduced catalytic mechanism of PP2C phosphatases are similar to the PP1, PP2A, PP2B family of protein Ser/Thr phosphatases, with which PP2C shares no sequence...; Region: PP2Cc; cl00120 508765004807 active site 508765004808 Serine/threonine phosphatases, family 2C, catalytic domain; The protein architecture and deduced catalytic mechanism of PP2C phosphatases are similar to the PP1, PP2A, PP2B family of protein Ser/Thr phosphatases, with which PP2C shares no sequence...; Region: PP2Cc; cl00120 508765004809 active site 508765004810 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cl17037 508765004811 nucleotide binding site [chemical binding]; other site 508765004812 Phage late control gene D protein (GPD); Region: Phage_GPD; pfam05954 508765004813 Phage late control gene D protein (GPD); Region: Phage_GPD; pfam05954 508765004814 Uncharacterized protein conserved in bacteria (DUF2345); Region: DUF2345; cl01733 508765004815 Pentapeptide repeats (9 copies); Region: Pentapeptide_4; pfam13599 508765004816 Pentapeptide repeats (9 copies); Region: Pentapeptide_4; pfam13599 508765004817 Domain of unknown function (DUF4280); Region: DUF4280; pfam14107 508765004818 Phage late control gene D protein (GPD); Region: Phage_GPD; pfam05954 508765004819 Rhs family protein [Cell envelope biogenesis, outer membrane]; Region: RhsA; COG3209 508765004820 Rhs family protein [Cell envelope biogenesis, outer membrane]; Region: RhsA; COG3209 508765004821 RHS Repeat; Region: RHS_repeat; pfam05593 508765004822 Rhs family protein [Cell envelope biogenesis, outer membrane]; Region: RhsA; COG3209 508765004823 RHS Repeat; Region: RHS_repeat; cl11982 508765004824 RHS repeat-associated core domain; Region: Rhs_assc_core; TIGR03696 508765004825 RHS repeat-associated core domain; Region: Rhs_assc_core; TIGR03696 508765004826 Domain of unknown function (DUF4284); Region: DUF4284; pfam14112 508765004827 RHS repeat-associated core domain; Region: Rhs_assc_core; TIGR03696 508765004828 Protein of unknown function (DUF3990); Region: DUF3990; pfam13151 508765004829 SMI1 / KNR4 family (SUKH-1); Region: SMI1_KNR4; pfam09346 508765004830 RHS repeat-associated core domain; Region: Rhs_assc_core; TIGR03696 508765004831 Putative transposase, YhgA-like; Region: Transposase_31; pfam04754 508765004832 SGNH_hydrolase, or GDSL_hydrolase, is a diverse family of lipases and esterases. The tertiary fold of the enzyme is substantially different from that of the alpha/beta hydrolase family and unique among all known hydrolases; its active site closely...; Region: SGNH_hydrolase; cl01053 508765004833 Suppressor of fused protein (SUFU); Region: SUFU; pfam05076 508765004834 Pentapeptide repeats (9 copies); Region: Pentapeptide_4; pfam13599 508765004835 Pentapeptide repeats (9 copies); Region: Pentapeptide_4; pfam13599 508765004836 Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805 508765004837 Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805 508765004838 Domain of unknown function (DUF4176); Region: DUF4176; pfam13780 508765004839 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 508765004840 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 508765004841 non-specific DNA binding site [nucleotide binding]; other site 508765004842 salt bridge; other site 508765004843 sequence-specific DNA binding site [nucleotide binding]; other site 508765004844 Mn2+ and Fe2+ transporters of the NRAMP family [Inorganic ion transport and metabolism]; Region: MntH; COG1914 508765004845 Natural resistance-associated macrophage protein; Region: Nramp; pfam01566 508765004846 Molecular chaperone [Posttranslational modification, protein turnover, chaperones]; Region: DnaK; COG0443 508765004847 Nucleotide-binding domain of Escherichia coli HscC and similar proteins; Region: HscC_like_NBD; cd10235 508765004848 nucleotide binding site [chemical binding]; other site 508765004849 putative NEF/HSP70 interaction site [polypeptide binding]; other site 508765004850 SBD interface [polypeptide binding]; other site 508765004851 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 508765004852 TPR motif; other site 508765004853 binding surface 508765004854 putative PEP-CTERM system TPR-repeat lipoprotein; Region: PEP_TPR_lipo; TIGR02917 508765004855 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 508765004856 binding surface 508765004857 TPR motif; other site 508765004858 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 508765004859 binding surface 508765004860 TPR motif; other site 508765004861 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 508765004862 binding surface 508765004863 TPR motif; other site 508765004864 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 508765004865 binding surface 508765004866 TPR motif; other site 508765004867 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 508765004868 binding surface 508765004869 TPR motif; other site 508765004870 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 508765004871 binding surface 508765004872 TPR motif; other site 508765004873 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 508765004874 binding surface 508765004875 TPR motif; other site 508765004876 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 508765004877 binding surface 508765004878 TPR motif; other site 508765004879 ADP-ribose pyrophosphatase [Nucleotide transport and metabolism]; Region: COG1051 508765004880 Uncharacterized conserved protein [General function prediction only]; Region: COG4111 508765004881 nudix motif; other site 508765004882 Phosphoribosylpyrophosphate synthetase [Nucleotide transport and metabolism / Amino acid transport and metabolism]; Region: PrsA; COG0462 508765004883 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 508765004884 active site 508765004885 putative nicotinate phosphoribosyltransferase; Provisional; Region: PRK09198 508765004886 pre-B-cell colony-enhancing factor (PBEF)-like. The mammalian members of this group of nicotinate phosphoribosyltransferases (NAPRTases) were originally identified as genes whose expression is upregulated upon activation in lymphoid cells. In general; Region: PBEF_like; cd01569 508765004887 active site 508765004888 Domain of unknown function (DUF1768); Region: DUF1768; pfam08719 508765004889 Peptidase S8 family domain in CspA-like proteins; Region: Peptidases_S8_CspA-like; cd07478 508765004890 active site 508765004891 catalytic triad [active] 508765004892 Peptidase S8 family domain in CspA-like proteins; Region: Peptidases_S8_CspA-like; cd07478 508765004893 active site 508765004894 catalytic triad [active] 508765004895 aldehyde dehydrogenase family protein; Provisional; Region: PTZ00381 508765004896 Bacillus subtilis aldehyde dehydrogenase ywdH-like; Region: ALDH_YwdH-P39616; cd07136 508765004897 NAD(P) binding site [chemical binding]; other site 508765004898 catalytic residues [active] 508765004899 bifunctional glutamate--cysteine ligase/glutathione synthetase; Provisional; Region: PRK02471 508765004900 Glutamate-cysteine ligase; Region: Glu_cys_ligase; cl17352 508765004901 ATP-grasp domain; Region: ATP-grasp_4; cl17255 508765004902 Nudix hydrolase is a superfamily of enzymes found in all three kingdoms of life, and it catalyzes the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+...; Region: Nudix_Hydrolase; cl00447 508765004903 Nudix hydrolase is a superfamily of enzymes found in all three kingdoms of life, and it catalyzes the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+...; Region: Nudix_Hydrolase; cl00447 508765004904 nudix motif; other site 508765004905 Uncharacterized subfamily of the multidrug and toxic compound extrusion (MATE) proteins; Region: MATE_like_4; cd13144 508765004906 Na+-driven multidrug efflux pump [Defense mechanisms]; Region: NorM; COG0534 508765004907 Predicted transcriptional regulators [Transcription]; Region: COG1725 508765004908 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 508765004909 DNA-binding site [nucleotide binding]; DNA binding site 508765004910 ABC-type multidrug transport system, ATPase component [Defense mechanisms]; Region: CcmA; COG1131 508765004911 ATP-binding cassette domain of the drug resistance transporter and related proteins, subfamily A; Region: ABC_DR_subfamily_A; cd03230 508765004912 Walker A/P-loop; other site 508765004913 ATP binding site [chemical binding]; other site 508765004914 Q-loop/lid; other site 508765004915 ABC transporter signature motif; other site 508765004916 Walker B; other site 508765004917 D-loop; other site 508765004918 H-loop/switch region; other site 508765004919 16S rRNA uridine-516 pseudouridylate synthase and related pseudouridylate synthases [Translation, ribosomal structure and biogenesis]; Region: RsuA; COG1187 508765004920 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 508765004921 RNA binding surface [nucleotide binding]; other site 508765004922 Pseudouridine synthases, RsuA subfamily; Region: PseudoU_synth_RsuA_like; cd02870 508765004923 active site 508765004924 Transcriptional regulators [Transcription]; Region: RpiR; COG1737 508765004925 Helix-turn-helix domain, rpiR family; Region: HTH_6; pfam01418 508765004926 RpiR-like protein. RpiR contains a SIS (Sugar ISomerase) domain, which is found in many phosphosugar isomerases and phosphosugar binding proteins. In E. coli, rpiR negatively regulates the expression of rpiB gene. Both rpiB and rpiA are ribose phosphate...; Region: SIS_RpiR; cd05013 508765004927 putative active site [active] 508765004928 Nucleotidyltransferase (NT) domain of ClassII CCA-adding enzymes; Region: NT_ClassII-CCAase; cd05398 508765004929 tRNA nucleotidyltransferase/poly(A) polymerase [Translation, ribosomal structure and biogenesis]; Region: PcnB; COG0617 508765004930 active site 508765004931 NTP binding site [chemical binding]; other site 508765004932 metal binding triad [ion binding]; metal-binding site 508765004933 Probable RNA and SrmB- binding site of polymerase A; Region: PolyA_pol_RNAbd; pfam12627 508765004934 tRNA nucleotidyltransferase domain 2 putative; Region: tRNA_NucTran2_2; pfam13735 508765004935 Late competence development protein ComFB; Region: ComFB; pfam10719 508765004936 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 508765004937 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 508765004938 active site 508765004939 phosphorylation site [posttranslational modification] 508765004940 intermolecular recognition site; other site 508765004941 dimerization interface [polypeptide binding]; other site 508765004942 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 508765004943 DNA binding site [nucleotide binding] 508765004944 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 508765004945 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 508765004946 dimer interface [polypeptide binding]; other site 508765004947 phosphorylation site [posttranslational modification] 508765004948 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 508765004949 ATP binding site [chemical binding]; other site 508765004950 Mg2+ binding site [ion binding]; other site 508765004951 G-X-G motif; other site 508765004952 Putative lysophospholipase; Region: Hydrolase_4; pfam12146 508765004953 Alpha/beta hydrolase family; Region: Abhydrolase_5; pfam12695 508765004954 Predicted membrane-bound metal-dependent hydrolase (DUF457); Region: DUF457; pfam04307 508765004955 Uncharacterized conserved protein (DUF2196); Region: DUF2196; pfam09962 508765004956 DNA topoisomerase III; Provisional; Region: PRK07726 508765004957 TOPRIM_TopoIA_TopoIII: The topoisomerase-primase (TORPIM) domain found in members of the type IA family of DNA topoisomerases (Topo IA) similar to topoisomerase III. Type IA DNA topoisomerases remove (relax) negative supercoils in the DNA by: cleaving...; Region: TOPRIM_TopoIA_TopoIII; cd03362 508765004958 active site 508765004959 putative interdomain interaction site [polypeptide binding]; other site 508765004960 putative metal-binding site [ion binding]; other site 508765004961 putative nucleotide binding site [chemical binding]; other site 508765004962 DNA Topoisomerase, subtype IA; DNA-binding, ATP-binding and catalytic domain of bacterial DNA topoisomerases I and III, and eukaryotic DNA topoisomerase III and eubacterial and archael reverse gyrases. Topoisomerases clevage single or double stranded DNA...; Region: TOP1Ac; cd00186 508765004963 domain I; other site 508765004964 DNA binding groove [nucleotide binding] 508765004965 phosphate binding site [ion binding]; other site 508765004966 domain II; other site 508765004967 domain III; other site 508765004968 nucleotide binding site [chemical binding]; other site 508765004969 catalytic site [active] 508765004970 domain IV; other site 508765004971 DEDDh 3'-5' exonuclease domain family; Region: DEDDh; cd06127 508765004972 bifunctional ATP-dependent DNA helicase/DNA polymerase III subunit epsilon; Validated; Region: PRK08074 508765004973 active site 508765004974 catalytic site [active] 508765004975 substrate binding site [chemical binding]; other site 508765004976 DEAD/DEAH box helicase; Region: DEAD; pfam00270 508765004977 ATP binding site [chemical binding]; other site 508765004978 Helicase C-terminal domain; Region: Helicase_C_2; pfam13307 508765004979 Subfamily of the multidrug and toxic compound extrusion (MATE)-like proteins similar to Streptococcus aureus MepA; Region: MATE_MepA_like; cd13143 508765004980 putative efflux protein, MATE family; Region: matE; TIGR00797 508765004981 Major Facilitator Superfamily; Region: MFS_1; pfam07690 508765004982 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 508765004983 xanthine permease; Region: pbuX; TIGR03173 508765004984 xanthine phosphoribosyltransferase; Validated; Region: PRK09219 508765004985 Na+-driven multidrug efflux pump [Defense mechanisms]; Region: NorM; COG0534 508765004986 Uncharacterized subfamily of the multidrug and toxic compound extrusion (MATE) proteins; Region: MATE_like_8; cd13134 508765004987 pyruvate carboxylase; Reviewed; Region: PRK12999 508765004988 Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289 508765004989 Carbamoyl-phosphate synthase L chain, ATP binding domain; Region: CPSase_L_D2; pfam02786 508765004990 Biotin carboxylase C-terminal domain; Region: Biotin_carb_C; smart00878 508765004991 Pyruvate carboxylase and Transcarboxylase 5S, carboxyltransferase domain; Region: DRE_TIM_PC_TC_5S; cd07937 508765004992 active site 508765004993 catalytic residues [active] 508765004994 metal binding site [ion binding]; metal-binding site 508765004995 homodimer binding site [polypeptide binding]; other site 508765004996 The biotinyl-domain or biotin carboxyl carrier protein (BCCP) domain is present in all biotin-dependent enzymes, such as acetyl-CoA carboxylase, pyruvate carboxylase, propionyl-CoA carboxylase, methylcrotonyl-CoA carboxylase, geranyl-CoA carboxylase; Region: biotinyl_domain; cd06850 508765004997 carboxyltransferase (CT) interaction site; other site 508765004998 biotinylation site [posttranslational modification]; other site 508765004999 Family 41 Carbohydrate-Binding Module from pullulanase-like enzymes; Region: CBM41_pullulanase; cd10315 508765005000 carbohydrate binding site [chemical binding]; other site 508765005001 Family 41 Carbohydrate-Binding Module from pullulanase-like enzymes; Region: CBM41_pullulanase; cd10315 508765005002 carbohydrate binding site [chemical binding]; other site 508765005003 pullulanase, type I; Region: pulA_typeI; TIGR02104 508765005004 Early set domain associated with the catalytic domain of pullulanase (also called dextrinase and alpha-dextrin endo-1,6-alpha glucosidase); Region: E_set_Pullulanase; cd02860 508765005005 Alpha amylase catalytic domain found in Pullulanase (also called dextrinase; alpha-dextrin endo-1,6-alpha glucosidase), limit dextrinase, and related proteins; Region: AmyAc_Pullulanase_LD-like; cd11341 508765005006 Ca binding site [ion binding]; other site 508765005007 active site 508765005008 catalytic site [active] 508765005009 Domain of unknown function (DUF3372); Region: DUF3372; pfam11852 508765005010 N-ethylammeline chlorohydrolase; Provisional; Region: PRK06038 508765005011 TRZ/ATZ family contains enzymes from the atrazine degradation pathway and related hydrolases. Atrazine, a chlorinated herbizide, can be catabolized by a variety of different bacteria. The first three steps of the atrazine dehalogenation pathway are...; Region: ATZ_TRZ_like; cd01298 508765005012 active site 508765005013 putative substrate binding pocket [chemical binding]; other site 508765005014 T-box leader 508765005015 tyrosyl-tRNA synthetase; Provisional; Region: PRK13354 508765005016 catalytic core domain of tyrosinyl-tRNA synthetase; Region: TyrRS_core; cd00805 508765005017 active site 508765005018 HIGH motif; other site 508765005019 dimer interface [polypeptide binding]; other site 508765005020 KMSKS motif; other site 508765005021 purine nucleoside phosphorylase; Provisional; Region: PRK08202 508765005022 methylated-DNA--protein-cysteine methyltransferase; Provisional; Region: PRK00901 508765005023 The DNA repair protein O6-alkylguanine-DNA alkyltransferase (ATase; also known as AGT, AGAT and MGMT) reverses O6-alkylation DNA damage by transferring O6-alkyl adducts to an active site cysteine irreversibly, without inducing DNA strand breaks. ATases...; Region: ATase; cd06445 508765005024 DNA binding site [nucleotide binding] 508765005025 active site 508765005026 Iron only hydrogenase large subunit, C-terminal domain [General function prediction only]; Region: COG4624 508765005027 Iron only hydrogenase large subunit, C-terminal domain; Region: Fe_hyd_lg_C; pfam02906 508765005028 Nucleotidyltransferase (NT) domain of RelA- and SpoT-like ppGpp synthetases and hydrolases; Region: NT_Rel-Spo_like; cd05399 508765005029 synthetase active site [active] 508765005030 NTP binding site [chemical binding]; other site 508765005031 metal binding site [ion binding]; metal-binding site 508765005032 UDP-glucose 4-epimerase [Cell envelope biogenesis, outer membrane]; Region: GalE; COG1087 508765005033 UDP-glucose 4 epimerase, subgroup 1, extended (e) SDRs; Region: UDP_G4E_1_SDR_e; cd05247 508765005034 NAD binding site [chemical binding]; other site 508765005035 homodimer interface [polypeptide binding]; other site 508765005036 active site 508765005037 substrate binding site [chemical binding]; other site 508765005038 PreQ1 riboswitch 508765005039 QueT transporter; Region: QueT; pfam06177 508765005040 Class III nucleotidyl cyclases; Region: Nucleotidyl_cyc_III; cl11967 508765005041 nucleotidyl binding site; other site 508765005042 metal binding site [ion binding]; metal-binding site 508765005043 Catalytic NodB homology domain of the carbohydrate esterase 4 superfamily; Region: CE4_SF; cl15692 508765005044 Glycosyltransferases, probably involved in cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: COG1215 508765005045 CESA_like is the cellulose synthase superfamily; Region: CESA_like; cd06423 508765005046 DXD motif; other site 508765005047 Bacterial cellulose synthase subunit; Region: BcsB; cl15851 508765005048 ACT domain proteins similar to the yet uncharacterized Streptococcus pneumoniae ACT domain protein; Region: ACT_1ZPV; cd04872 508765005049 Uncharacterized proteins with similarity to Ribonucleotide reductase and Pyruvate formate lyase; Region: RNR_PFL_like_DUF711; cd08025 508765005050 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 508765005051 dimer interface [polypeptide binding]; other site 508765005052 putative CheW interface [polypeptide binding]; other site 508765005053 Sensory domain found in PocR; Region: PocR; pfam10114 508765005054 Predicted sensor domain [Signal transduction mechanisms / Transcription]; Region: PocR; COG4936 508765005055 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 508765005056 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 508765005057 DNA binding residues [nucleotide binding] 508765005058 dimerization interface [polypeptide binding]; other site 508765005059 FOG: CheY-like receiver [Signal transduction mechanisms]; Region: CheY; COG0784 508765005060 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 508765005061 active site 508765005062 phosphorylation site [posttranslational modification] 508765005063 intermolecular recognition site; other site 508765005064 dimerization interface [polypeptide binding]; other site 508765005065 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 508765005066 Zn2+ binding site [ion binding]; other site 508765005067 Mg2+ binding site [ion binding]; other site 508765005068 glycyl radical enzyme, PFL2/glycerol dehydratase family; Region: PFL2-3; TIGR01774 508765005069 Ribonucleotide reductase and Pyruvate formate lyase; Region: RNR_PFL; cl09939 508765005070 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 508765005071 Major Facilitator Superfamily; Region: MFS_1; pfam07690 508765005072 putative substrate translocation pore; other site 508765005073 glycyl-radical enzyme activating protein family; Region: PFLE_PFLC; TIGR02494 508765005074 anaerobic ribonucleotide reductase-activating protein; Provisional; Region: nrdG; cl15804 508765005075 EDD domain protein, DegV family; Region: DegV; TIGR00762 508765005076 Uncharacterized protein, DegV family COG1307; Region: DegV; pfam02645 508765005077 Radical SAM N-terminal; Region: Radical_SAM_N; pfam08497 508765005078 hypothetical protein; Provisional; Region: PRK00955 508765005079 Domain of unknown function (DUF3362); Region: DUF3362; pfam11842 508765005080 Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer); Region: MA; smart00283 508765005081 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 508765005082 dimer interface [polypeptide binding]; other site 508765005083 putative CheW interface [polypeptide binding]; other site 508765005084 Human Ape1-like subfamily of the ExoIII family purinic/apyrimidinic (AP) endonucleases; Region: Ape1-like_AP-endo; cd09087 508765005085 active site 508765005086 putative catalytic site [active] 508765005087 DNA binding site [nucleotide binding] 508765005088 putative phosphate binding site [ion binding]; other site 508765005089 metal binding site A [ion binding]; metal-binding site 508765005090 AP binding site [nucleotide binding]; other site 508765005091 metal binding site B [ion binding]; metal-binding site 508765005092 Lysophospholipase [Lipid metabolism]; Region: PldB; COG2267 508765005093 Putative lysophospholipase; Region: Hydrolase_4; pfam12146 508765005094 Predicted hydrolase of the alpha/beta superfamily [General function prediction only]; Region: COG2819 508765005095 Tet(M)-like family includes Tet(M), Tet(O), Tet(W), and OtrA, containing tetracycline resistant proteins; Region: TetM_like; cd04168 508765005096 Translation elongation factors (GTPases) [Translation, ribosomal structure and biogenesis]; Region: FusA; COG0480 508765005097 G1 box; other site 508765005098 putative GEF interaction site [polypeptide binding]; other site 508765005099 GTP/Mg2+ binding site [chemical binding]; other site 508765005100 Switch I region; other site 508765005101 G2 box; other site 508765005102 G3 box; other site 508765005103 Switch II region; other site 508765005104 G4 box; other site 508765005105 G5 box; other site 508765005106 Tet_II: This subfamily represents domain II of ribosomal protection proteins Tet(M) and Tet(O). This domain has homology to domain II of the elongation factors EF-G and EF-2. Tet(M) and Tet(O) catalyze the release of tetracycline (Tc) from the ribosome...; Region: Tet_II; cd03690 508765005107 Elongation Factor G-like domain IV. This family includes the translational elongation factor termed EF-2 (for Archaea and Eukarya) and EF-G (for Bacteria), ribosomal protection proteins that mediate tetracycline resistance and, an evolutionarily...; Region: EFG_like_IV; cl02789 508765005108 Tet_C: C-terminus of ribosomal protection proteins Tet(M) and Tet(O). This domain has homology to the C terminal domains of the elongation factors EF-G and EF-2. Tet(M) and Tet(O) catalyze the release of tetracycline (Tc) from the ribosome in a...; Region: Tet_C; cd03711 508765005109 Sodium:dicarboxylate symporter family; Region: SDF; cl00573 508765005110 Na+/H+-dicarboxylate symporters [Energy production and conversion]; Region: GltP; COG1301 508765005111 Alcohol dehydrogenase, class IV [Energy production and conversion]; Region: EutG; COG1454 508765005112 Dehydroquinate synthase-like (DHQ-like) and iron-containing alcohol dehydrogenases (Fe-ADH); Region: DHQ_Fe-ADH; cl02872 508765005113 active site 508765005114 NAD binding site [chemical binding]; other site 508765005115 metal binding site [ion binding]; metal-binding site 508765005116 propanediol utilization protein PduB; Provisional; Region: PRK15415 508765005117 1,2-propanediol utilization protein B (PduB), Bacterial Micro-Compartment (BMC) domain repeat 1; Region: BMC_PduB_repeat1; cd07047 508765005118 putative hexamer interface [polypeptide binding]; other site 508765005119 putative hexagonal pore; other site 508765005120 1,2-propanediol utilization protein B (PduB), Bacterial Micro-Compartment (BMC) domain repeat 2; Region: BMC_PduB_repeat2; cd07048 508765005121 putative hexamer interface [polypeptide binding]; other site 508765005122 putative hexagonal pore; other site 508765005123 Carbon dioxide concentrating mechanism/carboxysome shell protein [Secondary metabolites biosynthesis, transport, and catabolism / Energy production and conversion]; Region: CcmK; COG4577 508765005124 Carbon dioxide concentrating mechanism K (CcmK)-like proteins, Bacterial Micro-Compartment (BMC) domain; Region: BMC_CcmK_like; cd07045 508765005125 Hexamer interface [polypeptide binding]; other site 508765005126 Hexagonal pore residue; other site 508765005127 Carbon dioxide concentrating mechanism/carboxysome shell protein [Secondary metabolites biosynthesis, transport, and catabolism / Energy production and conversion]; Region: CcmK; COG4577 508765005128 1,2-propanediol utilization protein A (PduA), Bacterial Micro-Compartment (BMC) domain; Region: BMC_PduA; cd07059 508765005129 Hexamer interface [polypeptide binding]; other site 508765005130 Putative hexagonal pore residue; other site 508765005131 Carbon dioxide concentrating mechanism/carboxysome shell protein [Secondary metabolites biosynthesis, transport, and catabolism / Energy production and conversion]; Region: CcmK; COG4577 508765005132 1,2-propanediol utilization protein A (PduA), Bacterial Micro-Compartment (BMC) domain; Region: BMC_PduA; cd07059 508765005133 Hexamer interface [polypeptide binding]; other site 508765005134 Putative hexagonal pore residue; other site 508765005135 propanediol utilization phosphotransacylase; Provisional; Region: PRK15070 508765005136 Propanediol utilisation protein PduL; Region: PduL; pfam06130 508765005137 Propanediol utilisation protein PduL; Region: PduL; pfam06130 508765005138 ethanolamine utilization protein EutJ; Provisional; Region: PRK15080 508765005139 Flavoprotein; Region: Flavoprotein; pfam02441 508765005140 ethanolamine utilization protein; Region: eut_hyp; TIGR02536 508765005141 Ethanolamine utilisation protein and carboxysome structural protein domain family; Region: EutN_CcmL; cd01614 508765005142 Hexamer/Pentamer interface [polypeptide binding]; other site 508765005143 central pore; other site 508765005144 Ethanolamine utilization protein EutE-like; Region: ALDH_EutE; cd07121 508765005145 Aldehyde dehydrogenase family; Region: Aldedh; pfam00171 508765005146 putative catalytic cysteine [active] 508765005147 Respiratory-chain NADH dehydrogenase 51 Kd subunit; Region: Complex1_51K; pfam01512 508765005148 SLBB domain; Region: SLBB; pfam10531 508765005149 4Fe-4S dicluster domain; Region: Fer4_17; pfam13534 508765005150 M14 family of metallocarboxypeptidases and related proteins; Region: Peptidase_M14_like; cl11393 508765005151 PduT-like ethanolamine utilization protein; Region: eut_PduT; TIGR02526 508765005152 1,2-propanediol utilization protein T (PduT), Bacterial Micro-Compartment (BMC) domain repeat 1; Region: BMC_PduT_repeat1; cd07053 508765005153 putative hexamer interface [polypeptide binding]; other site 508765005154 putative hexagonal pore; other site 508765005155 1,2-propanediol utilization protein T (PduT), Bacterial Micro-Compartment (BMC) domain repeat 2; Region: BMC_PduT_repeat2; cd07054 508765005156 putative hexamer interface [polypeptide binding]; other site 508765005157 putative hexagonal pore; other site 508765005158 Threonyl and Alanyl tRNA synthetase second additional domain; Region: tRNA_SAD; smart00863 508765005159 DHHA1 domain; Region: DHHA1; pfam02272 508765005160 Protein of unknown function (DUF1113); Region: DUF1113; pfam06541 508765005161 Transcriptional regulators CsoR (copper-sensitive operon repressor), RcnR, and FrmR, and related domains; this domain superfamily was previously known as DUF156; Region: CsoR-like_DUF156; cl00846 508765005162 putative homodimer interface [polypeptide binding]; other site 508765005163 putative homotetramer interface [polypeptide binding]; other site 508765005164 putative allosteric switch controlling residues; other site 508765005165 putative metal binding site [ion binding]; other site 508765005166 putative homodimer-homodimer interface [polypeptide binding]; other site 508765005167 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 508765005168 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 508765005169 active site 508765005170 phosphorylation site [posttranslational modification] 508765005171 intermolecular recognition site; other site 508765005172 dimerization interface [polypeptide binding]; other site 508765005173 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 508765005174 DNA binding site [nucleotide binding] 508765005175 OPT oligopeptide transporter protein; Region: OPT; cl14607 508765005176 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 508765005177 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 508765005178 dimer interface [polypeptide binding]; other site 508765005179 phosphorylation site [posttranslational modification] 508765005180 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 508765005181 ATP binding site [chemical binding]; other site 508765005182 Mg2+ binding site [ion binding]; other site 508765005183 G-X-G motif; other site 508765005184 Na+/H+ antiporter [Energy production and conversion]; Region: NhaC; COG1757 508765005185 Predicted acetyltransferases and hydrolases with the alpha/beta hydrolase fold [General function prediction only]; Region: LipA; COG1075 508765005186 Putative serine esterase (DUF676); Region: DUF676; pfam05057 508765005187 CHAP domain; Region: CHAP; pfam05257 508765005188 Acetyltransferase (GNAT) domain; Region: Acetyltransf_3; pfam13302 508765005189 Acetyltransferase (GNAT) family; Region: Acetyltransf_1; pfam00583 508765005190 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 508765005191 Zn2+ binding site [ion binding]; other site 508765005192 Mg2+ binding site [ion binding]; other site 508765005193 Glucosyl transferase GtrII; Region: Glucos_trans_II; cl10304 508765005194 Protein of unknown function (DUF3829); Region: DUF3829; pfam12889 508765005195 Nucleoside/nucleotide kinase (NK) is a protein superfamily consisting of multiple families of enzymes that share structural similarity and are functionally related to the catalysis of the reversible phosphate group transfer from nucleoside triphosphates...; Region: NK; cl17190 508765005196 AAA domain; Region: AAA_18; pfam13238 508765005197 active site 508765005198 Uncharacterized conserved protein [Function unknown]; Region: COG1434 508765005199 YdcF-like. YdcF-like is a large family of mainly bacterial proteins, with a few members found in fungi, plants, and archaea. Escherichia coli YdcF has been shown to bind S-adenosyl-L-methionine (AdoMet), but a biochemical function has not been...; Region: YdcF-like; cd06259 508765005200 putative active site [active] 508765005201 hypothetical protein; Provisional; Region: PRK11770 508765005202 Domain of unknown function (DUF307); Region: DUF307; pfam03733 508765005203 Domain of unknown function (DUF307); Region: DUF307; pfam03733 508765005204 Superoxide dismutase [Inorganic ion transport and metabolism]; Region: SodA; COG0605 508765005205 Iron/manganese superoxide dismutases, alpha-hairpin domain; Region: Sod_Fe_N; pfam00081 508765005206 Iron/manganese superoxide dismutases, C-terminal domain; Region: Sod_Fe_C; pfam02777 508765005207 ABC-type multidrug transport system, ATPase component [Defense mechanisms]; Region: CcmA; COG1131 508765005208 ABC-type multidrug transport system, ATPase component; Region: ABC_drug_resistance_like; cd03264 508765005209 Walker A/P-loop; other site 508765005210 ATP binding site [chemical binding]; other site 508765005211 Q-loop/lid; other site 508765005212 ABC transporter signature motif; other site 508765005213 Walker B; other site 508765005214 D-loop; other site 508765005215 H-loop/switch region; other site 508765005216 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 508765005217 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 508765005218 active site 508765005219 phosphorylation site [posttranslational modification] 508765005220 intermolecular recognition site; other site 508765005221 dimerization interface [polypeptide binding]; other site 508765005222 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 508765005223 DNA binding site [nucleotide binding] 508765005224 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 508765005225 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 508765005226 dimer interface [polypeptide binding]; other site 508765005227 phosphorylation site [posttranslational modification] 508765005228 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 508765005229 ATP binding site [chemical binding]; other site 508765005230 Mg2+ binding site [ion binding]; other site 508765005231 G-X-G motif; other site 508765005232 TraX protein; Region: TraX; pfam05857 508765005233 Fe2+ transport system protein B [Inorganic ion transport and metabolism]; Region: FeoB; COG0370 508765005234 Ferrous iron transport protein B (FeoB) family; Region: FeoB; cd01879 508765005235 G1 box; other site 508765005236 GTP/Mg2+ binding site [chemical binding]; other site 508765005237 Switch I region; other site 508765005238 G2 box; other site 508765005239 G3 box; other site 508765005240 Switch II region; other site 508765005241 G4 box; other site 508765005242 G5 box; other site 508765005243 Nucleoside recognition; Region: Gate; pfam07670 508765005244 Ferrous iron transport protein B C terminus; Region: FeoB_C; pfam07664 508765005245 Nucleoside recognition; Region: Gate; pfam07670 508765005246 FeoA domain; Region: FeoA; pfam04023 508765005247 manganese transport transcriptional regulator; Provisional; Region: PRK03902 508765005248 Iron dependent repressor, N-terminal DNA binding domain; Region: Fe_dep_repress; pfam01325 508765005249 Iron dependent repressor, metal binding and dimerisation domain; Region: Fe_dep_repr_C; pfam02742 508765005250 Putative cell wall binding repeat; Region: CW_binding_1; pfam01473 508765005251 Putative cell wall binding repeat; Region: CW_binding_1; pfam01473 508765005252 Glycosyl hydrolase family 14; Region: Glyco_hydro_14; cl03185 508765005253 The family 20 carbohydrate-binding module (CBM20), also known as the starch-binding domain, is found in a large number of starch degrading enzymes including alpha-amylase, beta-amylase, glucoamylase, and CGTase (cyclodextrin glucanotransferase). CBM20 is...; Region: CBM20; cl15347 508765005254 starch-binding site 2 [chemical binding]; other site 508765005255 starch-binding site 1 [chemical binding]; other site 508765005256 Protein of unknown function, DUF488; Region: DUF488; pfam04343 508765005257 Cna protein B-type domain; Region: Cna_B; pfam05738 508765005258 Polymerase and Histidinol Phosphatase domain of Histidinol phosphate phosphatase; Region: PHP_HisPPase; cd07432 508765005259 active site 508765005260 PHP-associated; Region: PHP_C; pfam13263 508765005261 L,D-transpeptidase catalytic domain; Region: YkuD; pfam03734 508765005262 Uncharacterized protein conserved in bacteria [Function unknown]; Region: ErfK; COG1376 508765005263 Coenzyme A pyrophosphatase (CoAse), a member of the Nudix hydrolase superfamily, functions to catalyze the elimination of oxidized inactive CoA, which can inhibit CoA-utilizing enzymes. The need of CoAses mainly arises under conditions of oxidative...; Region: CoAse; cd03426 508765005264 putative active site [active] 508765005265 putative CoA binding site [chemical binding]; other site 508765005266 nudix motif; other site 508765005267 metal binding site [ion binding]; metal-binding site 508765005268 Heavy-metal-associated domain (HMA) is a conserved domain of approximately 30 amino acid residues found in a number of proteins that transport or detoxify heavy metals, for example, the CPx-type heavy metal ATPases and copper chaperones. HMA domain...; Region: HMA; cl00207 508765005269 DNA-binding transcriptional regulator DhaR; Provisional; Region: PRK11388 508765005270 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 508765005271 putative active site [active] 508765005272 heme pocket [chemical binding]; other site 508765005273 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 508765005274 Walker A motif; other site 508765005275 ATP binding site [chemical binding]; other site 508765005276 Walker B motif; other site 508765005277 arginine finger; other site 508765005278 Bacterial regulatory protein, Fis family; Region: HTH_8; pfam02954 508765005279 NADP(H)-dependent alcohol dehydrogenases; Region: NADP_ADH; cd08285 508765005280 Threonine dehydrogenase and related Zn-dependent dehydrogenases [Amino acid transport and metabolism / General function prediction only]; Region: Tdh; COG1063 508765005281 tetramer interface [polypeptide binding]; other site 508765005282 catalytic Zn binding site [ion binding]; other site 508765005283 NADP binding site [chemical binding]; other site 508765005284 Protein of unknown function (DUF2974); Region: DUF2974; pfam11187 508765005285 Protein of unknown function (DUF3829); Region: DUF3829; pfam12889 508765005286 Solute carrier families 5 and 6-like; solute binding domain; Region: SLC5-6-like_sbd; cl00456 508765005287 Na binding site [ion binding]; other site 508765005288 Pentapeptide repeats (9 copies); Region: Pentapeptide_4; pfam13599 508765005289 Pentapeptide repeats (9 copies); Region: Pentapeptide_4; pfam13599 508765005290 Protein of unknown function (DUF1653); Region: DUF1653; pfam07866 508765005291 HI0933-like protein; Region: HI0933_like; pfam03486 508765005292 cytidylate kinase; Provisional; Region: cmk; PRK00023 508765005293 Cytidine monophosphate kinase (CMPK) catalyzes the reversible phosphorylation of cytidine monophosphate (CMP) to produce cytidine diphosphate (CDP), using ATP as the preferred phosphoryl donor; Region: CMPK; cd02020 508765005294 CMP-binding site; other site 508765005295 The sites determining sugar specificity; other site 508765005296 4-hydroxy-3-methylbut-2-enyl diphosphate reductase/S1 RNA-binding domain protein; Reviewed; Region: PRK00087 508765005297 LytB protein; Region: LYTB; cl00507 508765005298 S1_RPS1_repeat_ec1_hs1: Ribosomal protein S1 (RPS1) domain. RPS1 is a component of the small ribosomal subunit thought to be involved in the recognition and binding of mRNA's during translation initiation. The bacterial RPS1 domain architecture...; Region: S1_RPS1_repeat_ec1_hs1; cd05687 508765005299 RNA binding site [nucleotide binding]; other site 508765005300 S1_RPS1_repeat_ec2_hs2: Ribosomal protein S1 (RPS1) domain. RPS1 is a component of the small ribosomal subunit thought to be involved in the recognition and binding of mRNA's during translation initiation. The bacterial RPS1 domain architecture...; Region: S1_RPS1_repeat_ec2_hs2; cd04465 508765005301 RNA binding site [nucleotide binding]; other site 508765005302 S1_RPS1_repeat_ec3: Ribosomal protein S1 (RPS1) domain. RPS1 is a component of the small ribosomal subunit thought to be involved in the recognition and binding of mRNA's during translation initiation. The bacterial RPS1 domain architecture consists...; Region: S1_RPS1_repeat_ec3; cd05688 508765005303 RNA binding site [nucleotide binding]; other site 508765005304 S1_RPS1_repeat_ec3: Ribosomal protein S1 (RPS1) domain. RPS1 is a component of the small ribosomal subunit thought to be involved in the recognition and binding of mRNA's during translation initiation. The bacterial RPS1 domain architecture consists...; Region: S1_RPS1_repeat_ec3; cd05688 508765005305 RNA binding site [nucleotide binding]; other site 508765005306 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 508765005307 Coenzyme A binding pocket [chemical binding]; other site 508765005308 (dimethylallyl)adenosine tRNA methylthiotransferase; Provisional; Region: PRK14328 508765005309 Uncharacterized protein family UPF0004; Region: UPF0004; pfam00919 508765005310 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 508765005311 FeS/SAM binding site; other site 508765005312 TRAM domain; Region: TRAM; pfam01938 508765005313 This CD includes cysteinyl-tRNA(Pro) deacylases from Haemophilus influenzae and Escherichia coli and other related bacterial proteins. These trans-acting, single-domain proteins are homologs of ProX and also the cis-acting prolyl-tRNA synthetase (ProRS)...; Region: YbaK_deacylase; cd00002 508765005314 putative deacylase active site [active] 508765005315 site-specific tyrosine recombinase XerC; Reviewed; Region: xerC; PRK00236 508765005316 DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213 508765005317 active site 508765005318 DNA binding site [nucleotide binding] 508765005319 Int/Topo IB signature motif; other site 508765005320 LexA repressor; Validated; Region: PRK00215 508765005321 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 508765005322 putative DNA binding site [nucleotide binding]; other site 508765005323 putative Zn2+ binding site [ion binding]; other site 508765005324 Peptidase S24 LexA-like proteins are involved in the SOS response leading to the repair of single-stranded DNA within the bacterial cell. This family includes: the lambda repressor CI/C2 family and related bacterial prophage repressor proteins; LexA (EC...; Region: S24_LexA-like; cd06529 508765005325 Catalytic site [active] 508765005326 Cystathionine beta-lyase family protein involved in aluminum resistance [Inorganic ion transport and metabolism]; Region: COG4100 508765005327 Aluminium resistance protein; Region: Alum_res; pfam06838 508765005328 bacterial Hfq-like; Region: Hfq; cd01716 508765005329 hexamer interface [polypeptide binding]; other site 508765005330 Sm1 motif; other site 508765005331 RNA binding site [nucleotide binding]; other site 508765005332 Sm2 motif; other site 508765005333 tRNA delta(2)-isopentenylpyrophosphate transferase; Reviewed; Region: miaA; PRK00091 508765005334 tRNA delta(2)-isopentenylpyrophosphate transferase [Translation, ribosomal structure and biogenesis]; Region: MiaA; COG0324 508765005335 DNA mismatch repair protein; Reviewed; Region: mutL; PRK00095 508765005336 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 508765005337 ATP binding site [chemical binding]; other site 508765005338 Mg2+ binding site [ion binding]; other site 508765005339 G-X-G motif; other site 508765005340 MutL_Trans: transducer domain, having a ribosomal S5 domain 2-like fold, conserved in the C-terminal domain of DNA mismatch repair (MutL/MLH1/PMS2) family. This transducer domain is homologous to the second domain of the DNA gyrase B subunit, which is...; Region: MutL_Trans; cd00782 508765005341 ATP binding site [chemical binding]; other site 508765005342 MutL C terminal dimerisation domain; Region: MutL_C; smart00853 508765005343 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 508765005344 DNA-binding site [nucleotide binding]; DNA binding site 508765005345 trehalose operon repressor, B. subtilis-type; Region: trehalos_R_Bsub; TIGR02404 508765005346 The UbiC transcription regulator-associated (UTRA) domain is a conserved ligand-binding domain; Region: UTRA; smart00866 508765005347 alpha,alpha-phosphotrehalase; Region: trehalose_treC; TIGR02403 508765005348 Alpha amylase catalytic domain found in Sucrose isomerases, oligo-1,6-glucosidase (also called isomaltase; sucrase-isomaltase; alpha-limit dextrinase), dextran glucosidase (also called glucan 1,6-alpha-glucosidase), and related proteins; Region: AmyAc_SI_OligoGlu_DGase; cd11333 508765005349 Ca binding site [ion binding]; other site 508765005350 active site 508765005351 catalytic site [active] 508765005352 PTS system, trehalose-specific IIBC component; Region: PTS-IIBC-Tre; TIGR01992 508765005353 PTS_IIB, PTS system, glucose/sucrose specific IIB subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIB_glc; cd00212 508765005354 active site turn [active] 508765005355 phosphorylation site [posttranslational modification] 508765005356 Phosphotransferase system IIC components, glucose/maltose/N-acetylglucosamine-specific [Carbohydrate transport and metabolism]; Region: PtsG; COG1263 508765005357 DNA mismatch repair protein MutS; Provisional; Region: PRK05399 508765005358 MutS domain I; Region: MutS_I; pfam01624 508765005359 MutS domain II; Region: MutS_II; pfam05188 508765005360 MutS domain III; Region: MutS_III; pfam05192 508765005361 ATP-binding cassette domain of MutS1 homolog; Region: ABC_MutS1; cd03284 508765005362 Walker A/P-loop; other site 508765005363 ATP binding site [chemical binding]; other site 508765005364 Q-loop/lid; other site 508765005365 ABC transporter signature motif; other site 508765005366 Walker B; other site 508765005367 D-loop; other site 508765005368 H-loop/switch region; other site 508765005369 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 508765005370 Radical SAM superfamily; Region: Radical_SAM; pfam04055 508765005371 FeS/SAM binding site; other site 508765005372 Uncharacterized membrane protein [Function unknown]; Region: SapB; COG1285 508765005373 MgtC family; Region: MgtC; pfam02308 508765005374 Glycerophosphoryl diester phosphodiesterase [Energy production and conversion]; Region: UgpQ; COG0584 508765005375 Glycerophosphodiester phosphodiesterase domain of Thermoanaerobacter tengcongensis and similar proteins; Region: GDPD_TtGDE_like; cd08563 508765005376 active site 508765005377 catalytic site [active] 508765005378 metal binding site [ion binding]; metal-binding site 508765005379 dimer interface [polypeptide binding]; other site 508765005380 Uncharacterized membrane protein [Function unknown]; Region: SapB; COG1285 508765005381 MgtC family; Region: MgtC; pfam02308 508765005382 Bacterial SNF2 helicase associated; Region: SNF2_assoc; pfam08455 508765005383 SNF2 family N-terminal domain; Region: SNF2_N; pfam00176 508765005384 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 508765005385 ATP binding site [chemical binding]; other site 508765005386 putative Mg++ binding site [ion binding]; other site 508765005387 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 508765005388 nucleotide binding region [chemical binding]; other site 508765005389 ATP-binding site [chemical binding]; other site 508765005390 ATPase components of ABC transporters with duplicated ATPase domains [General function prediction only]; Region: Uup; COG0488 508765005391 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 508765005392 Walker A/P-loop; other site 508765005393 ATP binding site [chemical binding]; other site 508765005394 Q-loop/lid; other site 508765005395 ABC transporter signature motif; other site 508765005396 Walker B; other site 508765005397 D-loop; other site 508765005398 H-loop/switch region; other site 508765005399 ABC transporter; Region: ABC_tran_2; pfam12848 508765005400 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 508765005401 phytoene desaturase; Region: crtI_fam; TIGR02734 508765005402 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450 508765005403 D-alanyl-D-alanine carboxypeptidase; Region: Peptidase_M15_4; pfam13539 508765005404 Putative amidase domain; Region: Amidase_6; pfam12671 508765005405 Superoxide dismutase [Inorganic ion transport and metabolism]; Region: SodA; COG0605 508765005406 Iron/manganese superoxide dismutases, alpha-hairpin domain; Region: Sod_Fe_N; pfam00081 508765005407 Iron/manganese superoxide dismutases, C-terminal domain; Region: Sod_Fe_C; pfam02777 508765005408 Members of the Nudix hydrolase superfamily catalyze the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+, for their activity. They also contain a...; Region: Nudix_Hydrolase_1; cd03674 508765005409 nudix motif; other site 508765005410 Predicted hydrolase (metallo-beta-lactamase superfamily) [General function prediction only]; Region: ComEC; COG2333 508765005411 Metallo-beta-lactamase superfamily; Region: Lactamase_B; pfam00753 508765005412 bifunctional UDP-sugar hydrolase/5'-nucleotidase periplasmic precursor; Reviewed; Region: ushA; PRK09558 508765005413 Escherichia coli UshA-like family, N-terminal metallophosphatase domain; Region: MPP_UshA_N_like; cd00845 508765005414 active site 508765005415 metal binding site [ion binding]; metal-binding site 508765005416 5'-nucleotidase, C-terminal domain; Region: 5_nucleotid_C; pfam02872 508765005417 glycyl-radical enzyme activating protein family; Region: PFLE_PFLC; TIGR02494 508765005418 anaerobic ribonucleotide reductase-activating protein; Provisional; Region: nrdG; cl15804 508765005419 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 508765005420 FeS/SAM binding site; other site 508765005421 glycyl radical enzyme, PFL2/glycerol dehydratase family; Region: PFL2-3; TIGR01774 508765005422 Pyruvate formate lyase 2 and related enzymes; Region: PFL2_DhaB_BssA; cd01677 508765005423 dimer interface [polypeptide binding]; other site 508765005424 active site 508765005425 glycine loop; other site 508765005426 Response regulator receiver domain; Region: Response_reg; pfam00072 508765005427 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 508765005428 active site 508765005429 phosphorylation site [posttranslational modification] 508765005430 intermolecular recognition site; other site 508765005431 dimerization interface [polypeptide binding]; other site 508765005432 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 508765005433 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 508765005434 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 508765005435 Sensory domain found in PocR; Region: PocR; pfam10114 508765005436 Predicted sensor domain [Signal transduction mechanisms / Transcription]; Region: PocR; COG4936 508765005437 Histidine kinase; Region: His_kinase; pfam06580 508765005438 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 508765005439 ATP binding site [chemical binding]; other site 508765005440 G-X-G motif; other site 508765005441 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 508765005442 Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248 508765005443 active site 508765005444 catalytic tetrad [active] 508765005445 potassium uptake protein, TrkH family; Region: 2a38; TIGR00933 508765005446 Trk-type K+ transport systems, membrane components [Inorganic ion transport and metabolism]; Region: TrkG; COG0168 508765005447 oligoendopeptidase, pepF/M3 family; Region: M3_fam_3; TIGR02290 508765005448 Peptidase family M3B Oligopeptidase F (PepF); Region: M3B_PepF_2; cd09607 508765005449 active site 508765005450 Zn binding site [ion binding]; other site 508765005451 Hemerythrin; Region: Hemerythrin; cd12107 508765005452 Fe binding site [ion binding]; other site 508765005453 FOG: TPR repeat, SEL1 subfamily [General function prediction only]; Region: COG0790 508765005454 Sel1-like repeats; Region: SEL1; smart00671 508765005455 Sel1-like repeats; Region: SEL1; smart00671 508765005456 Sel1-like repeats; Region: SEL1; smart00671 508765005457 Sel1-like repeats; Region: SEL1; smart00671 508765005458 Sel1-like repeats; Region: SEL1; smart00671 508765005459 Sel1-like repeats; Region: SEL1; smart00671 508765005460 Predicted Ser/Thr protein kinase [Signal transduction mechanisms]; Region: COG2112 508765005461 PAS domain S-box; Region: sensory_box; TIGR00229 508765005462 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cl02459 508765005463 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 508765005464 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 508765005465 dimer interface [polypeptide binding]; other site 508765005466 phosphorylation site [posttranslational modification] 508765005467 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 508765005468 ATP binding site [chemical binding]; other site 508765005469 Mg2+ binding site [ion binding]; other site 508765005470 G-X-G motif; other site 508765005471 PAS domain; Region: PAS_9; pfam13426 508765005472 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 508765005473 putative active site [active] 508765005474 heme pocket [chemical binding]; other site 508765005475 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 508765005476 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 508765005477 dimer interface [polypeptide binding]; other site 508765005478 phosphorylation site [posttranslational modification] 508765005479 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 508765005480 ATP binding site [chemical binding]; other site 508765005481 Mg2+ binding site [ion binding]; other site 508765005482 G-X-G motif; other site 508765005483 Putative redox-active protein (C_GCAxxG_C_C); Region: C_GCAxxG_C_C; pfam09719 508765005484 Amino acid permease; Region: AA_permease_2; pfam13520 508765005485 Transmembrane amino acid transporter protein; Region: Aa_trans; cl17468 508765005486 Cache domain; Region: Cache_1; pfam02743 508765005487 Methyl-accepting chemotaxis protein [Cell motility and secretion / Signal transduction mechanisms]; Region: Tar; COG0840 508765005488 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 508765005489 dimerization interface [polypeptide binding]; other site 508765005490 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 508765005491 dimer interface [polypeptide binding]; other site 508765005492 putative CheW interface [polypeptide binding]; other site 508765005493 Nucleoside Triphosphate Pyrophosphohydrolase (EC 3.6.1.8) MazG-like domain found in mouse RS21-C6 protein and its homologs; Region: NTP-PPase_RS21-C6_like; cd11537 508765005494 homodimer interface [polypeptide binding]; other site 508765005495 chemical substrate binding site [chemical binding]; other site 508765005496 oligomer interface [polypeptide binding]; other site 508765005497 metal binding site [ion binding]; metal-binding site 508765005498 Predicted transcriptional regulators [Transcription]; Region: SoxR; COG0789 508765005499 Helix-Turn-Helix DNA binding domain of the transcription regulators TipAL, Mta, and SkgA; Region: HTH_TipAL-Mta; cd01106 508765005500 DNA binding residues [nucleotide binding] 508765005501 dimer interface [polypeptide binding]; other site 508765005502 TipAS antibiotic-recognition domain; Region: TipAS; pfam07739 508765005503 CoA-disulfide reductase; Region: CoA_CoA_reduc; TIGR03385 508765005504 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500 508765005505 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 508765005506 Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain; Region: Pyr_redox_dim; pfam02852 508765005507 Member of the Rhodanese Homology Domain superfamily. Included in this CD are the Lactococcus lactis NADH oxidase, Bacillus cereus NADH dehydrogenase, and Bacteroides thetaiotaomicron pyridine nucleotide-disulphide oxidoreductase, and similar...; Region: RHOD_Pyr_redox; cd01524 508765005508 active site residue [active] 508765005509 SirA, YedF, and YeeD. Two-layered alpha/beta sandwich domain. SirA (also known as UvrY, and YhhP) belongs to a family of bacterial two-component response regulators that controls secondary metabolism and virulence. The other member of this...; Region: SirA_YedF_YeeD; cl00436 508765005510 CPxP motif; other site 508765005511 DsrE/DsrF/DrsH-like family; Region: DrsE_2; pfam13686 508765005512 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 508765005513 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 508765005514 active site 508765005515 phosphorylation site [posttranslational modification] 508765005516 intermolecular recognition site; other site 508765005517 dimerization interface [polypeptide binding]; other site 508765005518 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 508765005519 DNA binding site [nucleotide binding] 508765005520 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 508765005521 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 508765005522 dimer interface [polypeptide binding]; other site 508765005523 phosphorylation site [posttranslational modification] 508765005524 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 508765005525 ATP binding site [chemical binding]; other site 508765005526 Mg2+ binding site [ion binding]; other site 508765005527 G-X-G motif; other site 508765005528 Flagellar basal body-associated protein FliL; Region: FliL; pfam03748 508765005529 ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136 508765005530 ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255 508765005531 Walker A/P-loop; other site 508765005532 ATP binding site [chemical binding]; other site 508765005533 Q-loop/lid; other site 508765005534 ABC transporter signature motif; other site 508765005535 Walker B; other site 508765005536 D-loop; other site 508765005537 H-loop/switch region; other site 508765005538 FtsX-like permease family; Region: FtsX; pfam02687 508765005539 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 508765005540 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 508765005541 dimer interface [polypeptide binding]; other site 508765005542 phosphorylation site [posttranslational modification] 508765005543 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 508765005544 ATP binding site [chemical binding]; other site 508765005545 Mg2+ binding site [ion binding]; other site 508765005546 G-X-G motif; other site 508765005547 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 508765005548 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 508765005549 dimer interface [polypeptide binding]; other site 508765005550 phosphorylation site [posttranslational modification] 508765005551 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 508765005552 ATP binding site [chemical binding]; other site 508765005553 Mg2+ binding site [ion binding]; other site 508765005554 G-X-G motif; other site 508765005555 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 508765005556 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 508765005557 active site 508765005558 phosphorylation site [posttranslational modification] 508765005559 intermolecular recognition site; other site 508765005560 dimerization interface [polypeptide binding]; other site 508765005561 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 508765005562 DNA binding site [nucleotide binding] 508765005563 Mg/Co/Ni transporter MgtE (contains CBS domain) [Inorganic ion transport and metabolism]; Region: MgtE; COG2239 508765005564 MgtE intracellular N domain; Region: MgtE_N; smart00924 508765005565 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domain in the magnesium transporter, MgtE. MgtE and its homologs are found in eubacteria, archaebacteria, and eukaryota. Members of this family transport Mg2+ or other...; Region: CBS_pair_Mg_transporter; cd04606 508765005566 Divalent cation transporter; Region: MgtE; pfam01769 508765005567 Predicted phosphatase/phosphohexomutase [General function prediction only]; Region: COG0637 508765005568 haloacid dehalogenase-like hydrolase; Region: HAD; cl17202 508765005569 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 508765005570 motif II; other site 508765005571 hybrid cluster protein; Provisional; Region: PRK05290 508765005572 The HCP family of iron-sulfur proteins includes hybrid cluster protein (HCP), acetyl-CoA synthase (ACS), and carbon monoxide dehydrogenase (CODH), all of which contain [Fe4-S4] metal clusters at their active sites. These proteins have a conserved...; Region: HCP_like; cl14655 508765005573 ACS interaction site; other site 508765005574 CODH interaction site; other site 508765005575 The HCP family of iron-sulfur proteins includes hybrid cluster protein (HCP), acetyl-CoA synthase (ACS), and carbon monoxide dehydrogenase (CODH), all of which contain [Fe4-S4] metal clusters at their active sites. These proteins have a conserved...; Region: HCP_like; cl14655 508765005576 ACS interaction site; other site 508765005577 CODH interaction site; other site 508765005578 metal cluster binding site [ion binding]; other site 508765005579 TPR repeat; Region: TPR_11; pfam13414 508765005580 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 508765005581 binding surface 508765005582 TPR motif; other site 508765005583 Ferritin-like superfamily of diiron-containing four-helix-bundle proteins; Region: Ferritin_like; cd00657 508765005584 dinuclear metal binding motif [ion binding]; other site 508765005585 The BURPS668_1122 family of deaminases; Region: Toxin-deaminase; pfam14424 508765005586 Acetyltransferase (GNAT) domain; Region: Acetyltransf_9; pfam13527 508765005587 Sterol carrier protein domain; Region: SCP2_2; pfam13530 508765005588 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 508765005589 Major Facilitator Superfamily; Region: MFS_1; pfam07690 508765005590 putative substrate translocation pore; other site 508765005591 Transcriptional regulator [Transcription]; Region: LysR; COG0583 508765005592 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 508765005593 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cd05466 508765005594 dimerization interface [polypeptide binding]; other site 508765005595 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 508765005596 non-specific DNA binding site [nucleotide binding]; other site 508765005597 salt bridge; other site 508765005598 sequence-specific DNA binding site [nucleotide binding]; other site 508765005599 Predicted hydrolase (metallo-beta-lactamase superfamily) [General function prediction only]; Region: ComEC; COG2333 508765005600 Metallo-beta-lactamase superfamily; Region: Lactamase_B; smart00849 508765005601 FOG: Glucan-binding domain (YG repeat) [General function prediction only]; Region: COG5263 508765005602 Putative cell wall binding repeat; Region: CW_binding_1; pfam01473 508765005603 Putative cell wall binding repeat; Region: CW_binding_1; pfam01473 508765005604 YmaF family; Region: YmaF; pfam12788 508765005605 glucan-binding repeat; Region: glucan_65_rpt; TIGR04035 508765005606 lysozyme_like domain. This contains several members including Soluble Lytic Transglycosylases (SLT), Goose Egg-White Lysozymes (GEWL), Hen Egg-White Lysozymes (HEWL), chitinases, bacteriophage lambda lysozymes, endolysins, autolysins, and chitosanases; Region: lysozyme_like; cl00222 508765005607 catalytic residue [active] 508765005608 Protein of unknown function (DUF2762); Region: DUF2762; pfam10960 508765005609 Phage tail-collar fibre protein; Region: DUF3751; pfam12571 508765005610 Uncharacterized protein conserved in bacteria (DUF2313); Region: DUF2313; pfam10076 508765005611 Uncharacterized homolog of phage Mu protein gp47 [Function unknown]; Region: XkdT; COG3299 508765005612 Protein of unknown function (DUF2634); Region: DUF2634; pfam10934 508765005613 Protein of unknown function (DUF2577); Region: DUF2577; pfam10844 508765005614 Cell wall-associated hydrolases (invasion-associated proteins) [Cell envelope biogenesis, outer membrane]; Region: Spr; COG0791 508765005615 NlpC/P60 family; Region: NLPC_P60; pfam00877 508765005616 Soluble lytic murein transglycosylase and related regulatory proteins (some contain LysM/invasin domains) [Cell envelope biogenesis, outer membrane]; Region: MltE; COG0741 508765005617 Lytic Transglycosylase (LT) and Goose Egg White Lysozyme (GEWL) domain. Members include the soluble and insoluble membrane-bound LTs in bacteria, the LTs in bacteriophage lambda, as well as, the eukaryotic "goose-type" lysozymes (GEWL). LTs...; Region: LT_GEWL; cd00254 508765005618 N-acetyl-D-glucosamine binding site [chemical binding]; other site 508765005619 catalytic residue [active] 508765005620 Protein of unknown function (DUF2001); Region: DUF2001; pfam09393 508765005621 Phage tail sheath protein; Region: Phage_sheath_1; cl01389 508765005622 Domain of unknown function (DUF4355); Region: DUF4355; pfam14265 508765005623 Phage Mu protein F like protein; Region: Phage_Mu_F; cl10072 508765005624 phage portal protein, SPP1 family; Region: portal_SPP1; TIGR01538 508765005625 Phage portal protein, SPP1 Gp6-like; Region: Phage_prot_Gp6; pfam05133 508765005626 Site-specific recombinases, DNA invertase Pin homologs [DNA replication, recombination, and repair]; Region: PinR; COG1961 508765005627 Serine Recombinase (SR) family, Resolvase and Invertase subfamily, catalytic domain; members contain a C-terminal DNA binding domain. Serine recombinases catalyze site-specific recombination of DNA molecules by a concerted, four-strand cleavage and...; Region: SR_ResInv; cd03768 508765005628 catalytic residues [active] 508765005629 catalytic nucleophile [active] 508765005630 Presynaptic Site I dimer interface [polypeptide binding]; other site 508765005631 Synaptic Antiparallel dimer interface [polypeptide binding]; other site 508765005632 Synaptic Flat tetramer interface [polypeptide binding]; other site 508765005633 Synaptic Site I dimer interface [polypeptide binding]; other site 508765005634 DNA binding site [nucleotide binding] 508765005635 Homeodomain-like domain; Region: HTH_23; pfam13384 508765005636 Phage regulatory protein Rha (Phage_pRha); Region: Phage_pRha; cl10713 508765005637 RNA polymerase sigma-70 factor, sigma-B/F/G subfamily; Region: SigBFG; TIGR02980 508765005638 Nucleoside Triphosphate Pyrophosphohydrolase (EC 3.6.1.8) MazG-like domain found in a group of uncharacterized proteins from bacteria and archaea; Region: NTP-PPase_u2; cd11539 508765005639 metal binding site [ion binding]; metal-binding site 508765005640 Single-stranded DNA-binding protein [DNA replication, recombination, and repair]; Region: Ssb; COG0629 508765005641 SSB_OBF: A subfamily of OB folds similar to the OB fold of ssDNA-binding protein (SSB). SSBs bind with high affinity to ssDNA. They bind to and protect ssDNA intermediates during DNA metabolic pathways. All bacterial and eukaryotic SSBs studied to date...; Region: SSB_OBF; cd04496 508765005642 dimer interface [polypeptide binding]; other site 508765005643 ssDNA binding site [nucleotide binding]; other site 508765005644 tetramer (dimer of dimers) interface [polypeptide binding]; other site 508765005645 Recombination protein U; Region: RecU; cl01314 508765005646 DnaA N-terminal domain; Region: DnaA_N; pfam11638 508765005647 Protein of unknown function (DUF1351); Region: DUF1351; pfam07083 508765005648 ERF superfamily; Region: ERF; pfam04404 508765005649 Helix-turn-helix domain; Region: HTH_17; pfam12728 508765005650 SpoVT / AbrB like domain; Region: SpoVT_AbrB; smart00966 508765005651 ORF6N domain; Region: ORF6N; pfam10543 508765005652 ORF6C domain; Region: ORF6C; pfam10552 508765005653 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 508765005654 salt bridge; other site 508765005655 non-specific DNA binding site [nucleotide binding]; other site 508765005656 sequence-specific DNA binding site [nucleotide binding]; other site 508765005657 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 508765005658 non-specific DNA binding site [nucleotide binding]; other site 508765005659 salt bridge; other site 508765005660 sequence-specific DNA binding site [nucleotide binding]; other site 508765005661 DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213 508765005662 active site 508765005663 DNA binding site [nucleotide binding] 508765005664 Int/Topo IB signature motif; other site 508765005665 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 508765005666 non-specific DNA binding site [nucleotide binding]; other site 508765005667 salt bridge; other site 508765005668 sequence-specific DNA binding site [nucleotide binding]; other site 508765005669 Pleckstrin homology (PH)-like domains in bacteria (PHb); Region: PH-like_bacteria; cd13225 508765005670 pentamer interface [polypeptide binding]; other site 508765005671 dodecaamer interface [polypeptide binding]; other site 508765005672 Uncharacterized conserved protein [Function unknown]; Region: COG2454 508765005673 Permeases of the drug/metabolite transporter (DMT) superfamily [Carbohydrate transport and metabolism / Amino acid transport and metabolism / General function prediction only]; Region: RhaT; COG0697 508765005674 Exonuclease-Endonuclease-Phosphatase domain; uncharacterized family 1; Region: EEP-1; cd09083 508765005675 putative catalytic site [active] 508765005676 putative metal binding site [ion binding]; other site 508765005677 putative phosphate binding site [ion binding]; other site 508765005678 Protein of unknown function (DUF4004); Region: DUF4004; pfam13171 508765005679 Reverse transcriptase (RNA-dependent DNA polymerase); Region: RVT_1; pfam00078 508765005680 RT_Bac_retron_II: Reverse transcriptases (RTs) in bacterial retrotransposons or retrons. The polymerase reaction of this enzyme leads to the production of a unique RNA-DNA complex called msDNA (multicopy single-stranded (ss)DNA) in which a small ssDNA...; Region: RT_Bac_retron_II; cd03487 508765005681 putative active site [active] 508765005682 putative NTP binding site [chemical binding]; other site 508765005683 putative nucleic acid binding site [nucleotide binding]; other site 508765005684 Xanthine/uracil/vitamin C permease [Nucleotide transport and metabolism]; Region: COG2252 508765005685 BlaR1 peptidase M56; Region: Peptidase_M56; pfam05569 508765005686 Penicillinase repressor; Region: Pencillinase_R; pfam03965 508765005687 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 508765005688 dimerization interface [polypeptide binding]; other site 508765005689 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 508765005690 dimer interface [polypeptide binding]; other site 508765005691 putative CheW interface [polypeptide binding]; other site 508765005692 tryptophan synthase, beta subunit; Region: trpB; TIGR00263 508765005693 Tryptophan synthase-beta: Trptophan synthase is a bifunctional enzyme that catalyses the last two steps in the biosynthesis of L-tryptophan via its alpha and beta reactions. In the alpha reaction, indole 3-glycerol phosphate is cleaved reversibly to...; Region: Trp-synth_B; cd06446 508765005694 pyridoxal 5'-phosphate binding site [chemical binding]; other site 508765005695 catalytic residue [active] 508765005696 UvrD/REP helicase N-terminal domain; Region: UvrD-helicase; pfam00580 508765005697 Family description; Region: UvrD_C_2; pfam13538 508765005698 Uncharacterized Zn-ribbon-containing protein involved in phosphonate metabolism [Inorganic ion transport and metabolism]; Region: PhnA; COG2824 508765005699 PhnA Zinc-Ribbon; Region: PhnA_Zn_Ribbon; pfam08274 508765005700 PhnA protein; Region: PhnA; pfam03831 508765005701 cAMP-binding proteins - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases [Signal transduction mechanisms]; Region: Crp; COG0664 508765005702 effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038 508765005703 ligand binding site [chemical binding]; other site 508765005704 flexible hinge region; other site 508765005705 helix_turn_helix, cAMP Regulatory protein C-terminus; DNA binding domain of prokaryotic regulatory proteins belonging to the catabolite activator protein family; Region: HTH_CRP; cd00092 508765005706 non-specific DNA interactions [nucleotide binding]; other site 508765005707 DNA binding site [nucleotide binding] 508765005708 sequence specific DNA binding site [nucleotide binding]; other site 508765005709 putative cAMP binding site [chemical binding]; other site 508765005710 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 508765005711 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 508765005712 NADH:flavin oxidoreductases, Old Yellow Enzyme family [Energy production and conversion]; Region: NemA; COG1902 508765005713 Enoate reductase (ER)-like FMN-binding domain. Enoate reductase catalyzes the NADH-dependent reduction of carbon-carbon double bonds of several molecules, including nonactivated 2-enoates, alpha,beta-unsaturated aldehydes, cyclic ketones, and...; Region: ER_like_FMN; cd02931 508765005714 putative active site [active] 508765005715 putative FMN binding site [chemical binding]; other site 508765005716 putative substrate binding site [chemical binding]; other site 508765005717 putative catalytic residue [active] 508765005718 putative 4Fe-4S cluster binding site [ion binding]; other site 508765005719 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox_2; pfam07992 508765005720 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 508765005721 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500 508765005722 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 508765005723 Cytochrome b5-like Heme/Steroid binding domain; Region: Cyt-b5; cl02041 508765005724 ExsB is a transcription regulator related protein. It is a subfamily of a Adenosine nucleotide binding superfamily of proteins. This protein family is represented by a single member in nearly every completed large (> 1000 genes) prokaryotic genome. In...; Region: ExsB; cd01995 508765005725 Ligand Binding Site [chemical binding]; other site 508765005726 CoA-disulfide reductase; Region: CoA_CoA_reduc; TIGR03385 508765005727 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500 508765005728 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 508765005729 Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain; Region: Pyr_redox_dim; pfam02852 508765005730 Rhodanese Homology Domain (RHOD); an alpha beta fold domain found duplicated in the rhodanese protein. The cysteine containing enzymatically active version of the domain is also found in the Cdc25 class of protein phosphatases and a variety of proteins...; Region: RHOD; cd00158 508765005731 active site residue [active] 508765005732 Rhodanese Homology Domain (RHOD); an alpha beta fold domain found duplicated in the rhodanese protein. The cysteine containing enzymatically active version of the domain is also found in the Cdc25 class of protein phosphatases and a variety of proteins...; Region: RHOD; cd00158 508765005733 active site residue [active] 508765005734 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 508765005735 binding surface 508765005736 TPR motif; other site 508765005737 Tetratricopeptide repeat; Region: TPR_16; pfam13432 508765005738 helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347 508765005739 MarR family; Region: MarR; pfam01047 508765005740 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 508765005741 Short chain acyl-CoA dehydrogenases and eukaryotic short/branched chain acyl-CoA dehydrogenases; Region: SCAD_SBCAD; cd01158 508765005742 FAD binding site [chemical binding]; other site 508765005743 homotetramer interface [polypeptide binding]; other site 508765005744 substrate binding pocket [chemical binding]; other site 508765005745 catalytic base [active] 508765005746 Acyl CoA:acetate/3-ketoacid CoA transferase [Lipid metabolism]; Region: COG4670 508765005747 Coenzyme A transferase; Region: CoA_trans; smart00882 508765005748 Coenzyme A transferase; Region: CoA_trans; cl17247 508765005749 3-hydroxybutyryl-CoA dehydratase; Validated; Region: PRK05809 508765005750 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 508765005751 substrate binding site [chemical binding]; other site 508765005752 oxyanion hole (OAH) forming residues; other site 508765005753 trimer interface [polypeptide binding]; other site 508765005754 myosin-cross-reactive antigen; Provisional; Region: PRK13977 508765005755 probable dihydroxyacetone kinase regulator; Region: DHAK_reg; TIGR02366 508765005756 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 508765005757 Ferritin-like superfamily of diiron-containing four-helix-bundle proteins; Region: Ferritin_like; cl00264 508765005758 dinuclear metal binding motif [ion binding]; other site 508765005759 Protein of unknown function (DUF1349); Region: DUF1349; pfam07081 508765005760 maltose O-acetyltransferase; Provisional; Region: PRK10092 508765005761 Maltose O-acetyltransferase (MAT) and Galactoside O-acetyltransferase (GAT): MAT and GAT catalyze the CoA-dependent acetylation of the 6-hydroxyl group of their respective sugar substrates. MAT acetylates maltose and glucose exclusively at the C6...; Region: LbH_MAT_GAT; cd03357 508765005762 active site 508765005763 substrate binding site [chemical binding]; other site 508765005764 trimer interface [polypeptide binding]; other site 508765005765 CoA binding site [chemical binding]; other site 508765005766 Cupin domain; Region: Cupin_2; pfam07883 508765005767 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 508765005768 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 508765005769 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 508765005770 Nucleic-acid-binding protein containing Zn-ribbon domain (DUF2082); Region: DUF2082; cl01381 508765005771 putative iron-only hydrogenase system regulator; Region: hyd_TM1266; TIGR03959 508765005772 [FeFe] hydrogenase H-cluster radical SAM maturase HydG; Region: rSAM_HydG; TIGR03955 508765005773 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 508765005774 FeS/SAM binding site; other site 508765005775 Biotin and Thiamin Synthesis associated domain; Region: BATS; smart00876 508765005776 SLBB domain; Region: SLBB; pfam10531 508765005777 4Fe-4S binding domain; Region: Fer4; pfam00037 508765005778 [FeFe] hydrogenase, group A; Region: FeFe_hydrog_A; TIGR02512 508765005779 4Fe-4S binding domain; Region: Fer4; pfam00037 508765005780 Iron only hydrogenase large subunit, C-terminal domain; Region: Fe_hyd_lg_C; pfam02906 508765005781 Iron hydrogenase small subunit; Region: Fe_hyd_SSU; pfam02256 508765005782 hydrogenase isoenzymes formation protein HypD; Provisional; Region: PRK15062 508765005783 hydrogenase expression/formation protein HypD; Region: hypD; TIGR00075 508765005784 HypE (Hydrogenase expression/formation protein). HypE is involved in Ni-Fe hydrogenase biosynthesis. HypE dehydrates its own carbamoyl moiety in an ATP-dependent process to yield the enzyme thiocyanate. The N-terminal domain of HypE is related to the...; Region: HypE; cd02197 508765005785 dimerization interface [polypeptide binding]; other site 508765005786 hydrogenase expression/formation protein HypE; Region: hypE; TIGR02124 508765005787 ATP binding site [chemical binding]; other site 508765005788 HupF/HypC family; Region: HupF_HypC; pfam01455 508765005789 Acylphosphatase; Region: Acylphosphatase; pfam00708 508765005790 Hydrogenase maturation factor [Posttranslational modification, protein turnover, chaperones]; Region: HypF; COG0068 508765005791 HypF finger; Region: zf-HYPF; pfam07503 508765005792 HypF finger; Region: zf-HYPF; pfam07503 508765005793 Telomere recombination; Region: Sua5_yciO_yrdC; pfam01300 508765005794 Hydrogenase expression/synthesis hypA family; Region: HypA; pfam01155 508765005795 Hydrogenase specific C-terminal endopeptidases, also called Hydrogen Maturation Proteases (H2MP). These enzymes belong to the peptidase family M52. Maturation of [FeNi] hydrogenases includes formation of the nickel metallocenter, proteolytic processing...; Region: H2MP; cd00518 508765005796 nickel binding site [ion binding]; other site 508765005797 Ni,Fe-hydrogenase I large subunit [Energy production and conversion]; Region: HyaB; COG0374 508765005798 Nickel-dependent hydrogenase; Region: NiFeSe_Hases; pfam00374 508765005799 NADH ubiquinone oxidoreductase, 20 Kd subunit; Region: Oxidored_q6; pfam01058 508765005800 Transcriptional regulator [Transcription]; Region: LysR; COG0583 508765005801 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 508765005802 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 508765005803 dimerization interface [polypeptide binding]; other site 508765005804 4Fe-4S dicluster domain; Region: Fer4_10; pfam13237 508765005805 Ferredoxin [Energy production and conversion]; Region: NapF; COG1145 508765005806 4Fe-4S binding domain; Region: Fer4; cl02805 508765005807 Proteins of this family catalyze the reduction of flavin or nitrocompounds using NAD(P)H as electron donor in a obligatory two-electron transfer, utilizing FMN or FAD as cofactor. They are often found to be homodimers. Enzymes of this family are...; Region: Nitro_FMN_reductase; cl00514 508765005808 FMN binding site [chemical binding]; other site 508765005809 dimer interface [polypeptide binding]; other site 508765005810 Putative glucoamylase; Region: Glycoamylase; pfam10091 508765005811 Second GH94N domain of cyclic beta 1-2 glucan synthetase and similar domains; Region: GH94N_ChvB_NdvB_2_like; cd11753 508765005812 Cellobiose phosphorylase [Carbohydrate transport and metabolism]; Region: COG3459 508765005813 First GH94N domain of cyclic beta 1-2 glucan synthetase and similar domains; Region: GH94N_ChvB_NdvB_1_like; cd11756 508765005814 Protein of unknown function, DUF608; Region: DUF608; pfam04685 508765005815 Pentapeptide repeats containing protein [Function unknown]; Region: COG1357 508765005816 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 508765005817 ATP-binding cassette protein, ChvD family; Region: ABC_ABC_ChvD; TIGR03719 508765005818 ABC transporter; Region: ABC_tran_2; pfam12848 508765005819 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 508765005820 DNA polymerase III, epsilon subunit and related 3'-5' exonucleases [DNA replication, recombination, and repair]; Region: DnaQ; COG0847 508765005821 DEDDh 3'-5' exonuclease domain of Caenorhabditis elegans ERI-1, human 3' exonuclease, and similar proteins; Region: ERI-1_3'hExo_like; cd06133 508765005822 active site 508765005823 catalytic site [active] 508765005824 substrate binding site [chemical binding]; other site 508765005825 Transcriptional regulator [Transcription]; Region: LysR; COG0583 508765005826 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 508765005827 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cd05466 508765005828 dimerization interface [polypeptide binding]; other site 508765005829 F420-0:Gamma-glutamyl ligase; Region: F420_ligase; pfam01996 508765005830 F420-0:Gamma-glutamyl ligase; Region: F420_ligase; pfam01996 508765005831 DNA polymerase III subunit epsilon; Validated; Region: PRK06195 508765005832 an uncharacterized bacterial subgroup of the DEDDh 3'-5' exonuclease domain family with similarity to the epsilon subunit of DNA polymerase III; Region: DNA_pol_III_epsilon_like; cd06130 508765005833 active site 508765005834 catalytic site [active] 508765005835 substrate binding site [chemical binding]; other site 508765005836 Breast Cancer Suppressor Protein (BRCA1), carboxy-terminal domain. The BRCT domain is found within many DNA damage repair and cell cycle checkpoint proteins. The unique diversity of this domain superfamily allows BRCT modules to interact forming homo...; Region: BRCT; cd00027 508765005837 Dimer interface [polypeptide binding]; other site 508765005838 BRCT sequence motif; other site 508765005839 Domain of unknown function (DUF4163); Region: DUF4163; pfam13739 508765005840 Protein of unknown function (DUF3298); Region: DUF3298; pfam11738 508765005841 N-terminal Early set domain associated with the catalytic domain of cyclomaltodextrinase and pullulan-degrading enzymes; Region: E_set_CDase_PDE_N; cd02857 508765005842 homodimer interface [polypeptide binding]; other site 508765005843 Alpha amylase catalytic domain found in cyclomaltodextrinases and related proteins; Region: AmyAc_CMD; cd11338 508765005844 Glycosidases [Carbohydrate transport and metabolism]; Region: AmyA; COG0366 508765005845 active site 508765005846 homodimer interface [polypeptide binding]; other site 508765005847 catalytic site [active] 508765005848 maltose ABC transporter periplasmic protein; Reviewed; Region: malE; PRK09474 508765005849 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; cl17199 508765005850 ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395 508765005851 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 508765005852 dimer interface [polypeptide binding]; other site 508765005853 conserved gate region; other site 508765005854 putative PBP binding loops; other site 508765005855 ABC-ATPase subunit interface; other site 508765005856 ABC-type polysaccharide transport system, permease component [Carbohydrate transport and metabolism]; Region: LplB; COG4209 508765005857 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 508765005858 dimer interface [polypeptide binding]; other site 508765005859 conserved gate region; other site 508765005860 putative PBP binding loops; other site 508765005861 ABC-ATPase subunit interface; other site 508765005862 Transcriptional regulators [Transcription]; Region: PurR; COG1609 508765005863 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 508765005864 DNA binding site [nucleotide binding] 508765005865 domain linker motif; other site 508765005866 Type 1 periplasmic binding fold superfamily; Region: Periplasmic_Binding_Protein_Type_1; cl10011 508765005867 ABC-type cobalt transport system, ATPase component [Inorganic ion transport and metabolism]; Region: CbiO; COG1122 508765005868 First domain of the ATP-binding cassette component of cobalt transport system; Region: ABC_cobalt_CbiO_domain1; cd03225 508765005869 Walker A/P-loop; other site 508765005870 ATP binding site [chemical binding]; other site 508765005871 Q-loop/lid; other site 508765005872 ABC transporter signature motif; other site 508765005873 Walker B; other site 508765005874 D-loop; other site 508765005875 H-loop/switch region; other site 508765005876 cobalt ABC transporter, permease protein CbiQ; Region: CbiQ_TIGR; TIGR02454 508765005877 cobalt transport protein CbiM; Validated; Region: PRK06265 508765005878 Cobalt uptake substrate-specific transmembrane region; Region: CbiM; pfam01891 508765005879 PDGLE domain; Region: PDGLE; pfam13190 508765005880 large-conductance mechanosensitive channel; Reviewed; Region: mscL; PRK00567 508765005881 Large-conductance mechanosensitive channel, MscL; Region: MscL; cl00860 508765005882 TIM-barrel signal transduction protein; Region: TIM-br_sig_trns; pfam09370 508765005883 hypothetical protein; Provisional; Region: PRK02399 508765005884 Uncharacterized protein family (UPF0261); Region: UPF0261; pfam06792 508765005885 TIM-barrel signal transduction protein; Region: TIM-br_sig_trns; cl15424 508765005886 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 508765005887 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 508765005888 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 508765005889 Family of unknown function (DUF438); Region: DUF438; pfam04282 508765005890 Hemerythrin HHE cation binding domain; Region: Hemerythrin; pfam01814 508765005891 Domain of Unknown function (DUF542); Region: ScdA_N; pfam04405 508765005892 iron-sulfur cluster repair di-iron protein; Region: FeS_repair_RIC; TIGR03652 508765005893 Hemerythrin HHE cation binding domain; Region: Hemerythrin; pfam01814 508765005894 effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038 508765005895 global nitrogen regulator NtcA, cyanobacterial; Region: NtcA_cyano; TIGR03697 508765005896 ligand binding site [chemical binding]; other site 508765005897 flexible hinge region; other site 508765005898 helix_turn_helix, cAMP Regulatory protein C-terminus; DNA binding domain of prokaryotic regulatory proteins belonging to the catabolite activator protein family; Region: HTH_CRP; cd00092 508765005899 putative switch regulator; other site 508765005900 non-specific DNA interactions [nucleotide binding]; other site 508765005901 DNA binding site [nucleotide binding] 508765005902 sequence specific DNA binding site [nucleotide binding]; other site 508765005903 putative cAMP binding site [chemical binding]; other site 508765005904 Flavodoxin-like fold; Region: Flavodoxin_2; cl00438 508765005905 NADP-dependent glyceraldehyde-3-phosphate dehydrogenase; Provisional; Region: PLN00412 508765005906 NADP+-dependent non-phosphorylating glyceraldehyde 3-phosphate dehydrogenase and ALDH family 11; Region: ALDH_F11_NP-GAPDH; cd07082 508765005907 tetrameric interface [polypeptide binding]; other site 508765005908 activator binding site; other site 508765005909 NADP binding site [chemical binding]; other site 508765005910 substrate binding site [chemical binding]; other site 508765005911 catalytic residues [active] 508765005912 FAD_NAD(P)H binding domain of flavohemoglobin. Flavohemoglobins have a globin domain containing a B-type heme fused with a ferredoxin reductase-like FAD/NAD-binding domain. Flavohemoglobins detoxify nitric oxide (NO) via an NO dioxygenase reaction. The...; Region: flavohem_like_fad_nad_binding; cd06184 508765005913 FAD binding pocket [chemical binding]; other site 508765005914 FAD binding motif [chemical binding]; other site 508765005915 phosphate binding motif [ion binding]; other site 508765005916 beta-alpha-beta structure motif; other site 508765005917 NAD binding pocket [chemical binding]; other site 508765005918 Uncharacterized flavoproteins [Energy production and conversion]; Region: FpaA; COG0426 508765005919 Metallo-beta-lactamase superfamily; Region: Lactamase_B; smart00849 508765005920 Flavodoxin-like fold; Region: Flavodoxin_2; cl00438 508765005921 Rubredoxin [Energy production and conversion]; Region: COG1773 508765005922 Rubredoxin; nonheme iron binding domains containing a [Fe(SCys)4] center. Rubredoxins are small nonheme iron proteins. The iron atom is coordinated by four cysteine residues (Fe(S-Cys)4), but iron can also be replaced by cobalt, nickel or zinc. They are...; Region: rubredoxin; cd00730 508765005923 iron binding site [ion binding]; other site 508765005924 Uncharacterized conserved protein (DUF2249); Region: DUF2249; cl17719 508765005925 hybrid cluster protein; Provisional; Region: PRK05290 508765005926 The HCP family of iron-sulfur proteins includes hybrid cluster protein (HCP), acetyl-CoA synthase (ACS), and carbon monoxide dehydrogenase (CODH), all of which contain [Fe4-S4] metal clusters at their active sites. These proteins have a conserved...; Region: HCP_like; cl14655 508765005927 ACS interaction site; other site 508765005928 CODH interaction site; other site 508765005929 Hybrid cluster protein (HCP), formerly known as prismane, is thought to play a role in nitrogen metabolism but its specific function is unknown. HCP has three structural domains, an N-terminal alpha-helical domain, and two similar domains comprising a...; Region: HCP; cd01914 508765005930 hybrid metal cluster; other site 508765005931 serine/threonine protein kinase; Provisional; Region: PRK14879 508765005932 Peptidase family S41; Region: Peptidase_S41; pfam03572 508765005933 Active site serine [active] 508765005934 Putative esterase; Region: Esterase; pfam00756 508765005935 AraC-like ligand binding domain; Region: AraC_binding; pfam02311 508765005936 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 508765005937 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 508765005938 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 508765005939 TraX protein; Region: TraX; cl05434 508765005940 Major Facilitator Superfamily; Region: MFS_1; pfam07690 508765005941 ROK family protein (putative glucokinase); Region: ROK_glcA_fam; TIGR00744 508765005942 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cd00012 508765005943 nucleotide binding site [chemical binding]; other site 508765005944 Phosphomannose isomerase [Carbohydrate transport and metabolism]; Region: ManA; COG1482 508765005945 Alpha-Mannosidase Binding Domain of Atg19/34; Region: ABD; cl15429 508765005946 alpha,alpha-phosphotrehalase; Region: trehalose_treC; TIGR02403 508765005947 Alpha amylase catalytic domain found in Sucrose isomerases, oligo-1,6-glucosidase (also called isomaltase; sucrase-isomaltase; alpha-limit dextrinase), dextran glucosidase (also called glucan 1,6-alpha-glucosidase), and related proteins; Region: AmyAc_SI_OligoGlu_DGase; cd11333 508765005948 Ca binding site [ion binding]; other site 508765005949 active site 508765005950 catalytic site [active] 508765005951 Protein of unknown function (DUF1861); Region: DUF1861; pfam08950 508765005952 Transcriptional regulators [Transcription]; Region: PurR; COG1609 508765005953 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 508765005954 DNA binding site [nucleotide binding] 508765005955 Type 1 periplasmic binding fold superfamily; Region: Periplasmic_Binding_Protein_Type_1; cl10011 508765005956 Glycosyl hydrolase families: GH43, GH62, GH32, GH68; Region: GH43_62_32_68; cl14647 508765005957 active site 508765005958 ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395 508765005959 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 508765005960 dimer interface [polypeptide binding]; other site 508765005961 conserved gate region; other site 508765005962 putative PBP binding loops; other site 508765005963 ABC-ATPase subunit interface; other site 508765005964 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 508765005965 dimer interface [polypeptide binding]; other site 508765005966 conserved gate region; other site 508765005967 putative PBP binding loops; other site 508765005968 ABC-ATPase subunit interface; other site 508765005969 ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653 508765005970 The MutT pyrophosphohydrolase is a prototypical Nudix hydrolase that catalyzes the hydrolysis of nucleoside and deoxynucleoside triphosphates (NTPs and dNTPs) by substitution at a beta-phosphorus to yield a nucleotide monophosphate (NMP) and inorganic...; Region: MutT_pyrophosphohydrolase; cd03425 508765005971 active site 508765005972 8-oxo-dGMP binding site [chemical binding]; other site 508765005973 nudix motif; other site 508765005974 metal binding site [ion binding]; metal-binding site 508765005975 Protein of unknown function (DUF3791); Region: DUF3791; pfam12668 508765005976 Protein of unknown function (DUF3990); Region: DUF3990; pfam13151 508765005977 This conserved domain belongs to a superfamily including the bleomycin resistance protein, glyoxalase I, and type I ring-cleaving dioxygenases; Region: Glo_EDI_BRP_like_1; cd08352 508765005978 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 508765005979 putative metal binding site [ion binding]; other site 508765005980 N-terminal phage replisome organiser (Phage_rep_org_N); Region: Phage_rep_org_N; pfam09681 508765005981 Putative cell wall binding repeat; Region: CW_binding_1; pfam01473 508765005982 Mor transcription activator family; Region: Mor; cl02360 508765005983 Fibronectin-binding protein (FBP); Region: FBP; pfam07299 508765005984 RNA polymerase factor sigma-70; Validated; Region: PRK06811 508765005985 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 508765005986 DNA binding residues [nucleotide binding] 508765005987 Predicted AAA-ATPase; Region: AAA-ATPase_like; pfam09820 508765005988 Protein of unknown function (DUF1703); Region: DUF1703; pfam08011 508765005989 HsdM N-terminal domain; Region: HsdM_N; pfam12161 508765005990 N-6 DNA Methylase; Region: N6_Mtase; pfam02384 508765005991 Methyltransferase domain; Region: Methyltransf_26; pfam13659 508765005992 Type I restriction modification DNA specificity domain; Region: Methylase_S; pfam01420 508765005993 Restriction endonuclease S subunits [Defense mechanisms]; Region: HsdS; COG0732 508765005994 Type I restriction modification DNA specificity domain; Region: Methylase_S; pfam01420 508765005995 type I site-specific deoxyribonuclease, HsdR family; Region: hsdR; TIGR00348 508765005996 Type I restriction enzyme R protein N terminus (HSDR_N); Region: HSDR_N; pfam04313 508765005997 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 508765005998 ATP binding site [chemical binding]; other site 508765005999 putative Mg++ binding site [ion binding]; other site 508765006000 Type I restriction and modification enzyme - subunit R C terminal; Region: EcoR124_C; pfam12008 508765006001 Type I restriction modification DNA specificity domain; Region: Methylase_S; pfam01420 508765006002 HNH endonuclease; Region: HNH_4; pfam13395 508765006003 VanZ like family; Region: VanZ; pfam04892 508765006004 Nucleoside Triphosphate Pyrophosphohydrolase (EC 3.6.1.8) MazG-like domain found in a group of uncharacterized proteins from archaea and bacteria; Region: NTP-PPase_COG4997; cd11532 508765006005 Beta-lactamase; Region: Beta-lactamase; pfam00144 508765006006 Beta-lactamase class C and other penicillin binding proteins [Defense mechanisms]; Region: AmpC; COG1680 508765006007 PTS_IIA, PTS system, lactose/cellobiose specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_lac; cd00215 508765006008 methionine cluster; other site 508765006009 active site 508765006010 phosphorylation site [posttranslational modification] 508765006011 metal binding site [ion binding]; metal-binding site 508765006012 Alpha-galactosidases/6-phospho-beta-glucosidases, family 4 of glycosyl hydrolases [Carbohydrate transport and metabolism]; Region: CelF; COG1486 508765006013 Glycoside Hydrolases Family 4; Phospho-beta-glucosidase; Region: GH4_P_beta_glucosidase; cd05296 508765006014 NAD binding site [chemical binding]; other site 508765006015 sugar binding site [chemical binding]; other site 508765006016 divalent metal binding site [ion binding]; other site 508765006017 tetramer (dimer of dimers) interface [polypeptide binding]; other site 508765006018 dimer interface [polypeptide binding]; other site 508765006019 Phosphotransferase system cellobiose-specific component IIC [Carbohydrate transport and metabolism]; Region: CelB; COG1455 508765006020 cellobiose phosphotransferase system IIC component; Reviewed; Region: celD; PRK09592 508765006021 PTS_IIB_chitobiose_lichenan: subunit IIB of enzyme II (EII) of the N,N-diacetylchitobiose-specific and lichenan-specific phosphoenolpyruvate:carbohydrate phosphotransferase system (PTS). In these systems, EII is either a lichenan- or an N; Region: PTS_IIB_chitobiose_lichenan; cd05564 508765006022 active site 508765006023 P-loop; other site 508765006024 phosphorylation site [posttranslational modification] 508765006025 Major intrinsic protein (MIP) superfamily. Members of the MIP superfamily function as membrane channels that selectively transport water, small neutral molecules, and ions out of and between cells. The channel proteins share a common fold: the N-terminal...; Region: MIP; cd00333 508765006026 amphipathic channel; other site 508765006027 Asn-Pro-Ala signature motifs; other site 508765006028 Alcohol dehydrogenase, class IV [Energy production and conversion]; Region: EutG; COG1454 508765006029 Lactadehyde:propanediol oxidoreductase (LPO) catalyzes the interconversion between L-lactaldehyde and L-1,2-propanediol in Escherichia coli and other enterobacteria; Region: LPO; cd08176 508765006030 dimer interface [polypeptide binding]; other site 508765006031 active site 508765006032 metal binding site [ion binding]; metal-binding site 508765006033 Cobalamin adenosyltransferase; Region: Cob_adeno_trans; pfam01923 508765006034 Dehydratase medium subunit; Region: Dehydratase_MU; pfam02288 508765006035 Diol dehydratase reactivase ATPase-like domain; Region: DDR; pfam08841 508765006036 propanediol dehydratase small subunit; Provisional; Region: pduE; PRK15443 508765006037 propanediol dehydratase medium subunit; Provisional; Region: pduD; PRK15042 508765006038 Propanediol dehydratase, large subunit [Secondary metabolites biosynthesis, transport, and catabolism]; Region: PduC; COG4909 508765006039 Dehydratase large subunit. This family contains the large (alpha) subunit of B12-dependent glycerol dehydratases (GDHs) and B12-dependent diol dehydratases (DDHs). GDH is isofunctional with DDH. These enzymes can each catalyze the conversion of 1; Region: Dehydratase_LU; cd03687 508765006040 alpha-alpha subunit/dimer interface [polypeptide binding]; other site 508765006041 alpha-beta subunit interface [polypeptide binding]; other site 508765006042 alpha-gamma subunit interface [polypeptide binding]; other site 508765006043 active site 508765006044 substrate and K+ binding site; other site 508765006045 K+ binding site [ion binding]; other site 508765006046 cobalamin binding site [chemical binding]; other site 508765006047 Response regulator receiver domain; Region: Response_reg; pfam00072 508765006048 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 508765006049 active site 508765006050 phosphorylation site [posttranslational modification] 508765006051 intermolecular recognition site; other site 508765006052 dimerization interface [polypeptide binding]; other site 508765006053 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 508765006054 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 508765006055 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 508765006056 Predicted sensor domain [Signal transduction mechanisms / Transcription]; Region: PocR; COG4936 508765006057 Sensory domain found in PocR; Region: PocR; pfam10114 508765006058 Predicted signal transduction protein with a C-terminal ATPase domain [Signal transduction mechanisms]; Region: COG2972 508765006059 Histidine kinase; Region: His_kinase; pfam06580 508765006060 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 508765006061 ATP binding site [chemical binding]; other site 508765006062 Mg2+ binding site [ion binding]; other site 508765006063 G-X-G motif; other site 508765006064 Transglutaminase-like superfamily; Region: Transglut_core; pfam01841 508765006065 FOG: Glucan-binding domain (YG repeat) [General function prediction only]; Region: COG5263 508765006066 Putative cell wall binding repeat; Region: CW_binding_1; pfam01473 508765006067 Divergent AAA domain; Region: AAA_4; pfam04326 508765006068 Predicted transcriptional regulator containing an HTH domain and an uncharacterized domain shared with the mammalian protein Schlafen [Transcription]; Region: COG2865 508765006069 Nucleotidyltransferase (NT) domain of Staphylococcus aureus kanamycin nucleotidyltransferase, and similar proteins; Region: NT_KNTase_like; cd05403 508765006070 active site 508765006071 NTP binding site [chemical binding]; other site 508765006072 metal binding triad [ion binding]; metal-binding site 508765006073 Nucleotidyltransferase substrate binding protein like; Region: NTase_sub_bind; cl17552 508765006074 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 508765006075 Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248 508765006076 active site 508765006077 catalytic tetrad [active] 508765006078 ABC-type cobalamin/Fe3+-siderophores transport systems, ATPase components [Inorganic ion transport and metabolism / Coenzyme metabolism]; Region: FepC; COG1120 508765006079 ATP-binding component of iron-siderophores, vitamin B12 and hemin transporters and related proteins; Region: ABC_Iron-Siderophores_B12_Hemin; cd03214 508765006080 Walker A/P-loop; other site 508765006081 ATP binding site [chemical binding]; other site 508765006082 Q-loop/lid; other site 508765006083 ABC transporter signature motif; other site 508765006084 Walker B; other site 508765006085 D-loop; other site 508765006086 H-loop/switch region; other site 508765006087 iron-hydroxamate transporter permease subunit; Provisional; Region: PRK10577 508765006088 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550 508765006089 ABC-ATPase subunit interface; other site 508765006090 dimer interface [polypeptide binding]; other site 508765006091 putative PBP binding regions; other site 508765006092 ABC-type enterobactin transport system, permease component [Inorganic ion transport and metabolism]; Region: FepG; COG4779 508765006093 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550 508765006094 ABC-ATPase subunit interface; other site 508765006095 dimer interface [polypeptide binding]; other site 508765006096 putative PBP binding regions; other site 508765006097 Periplasmic binding protein FeuA. These proteins have predicted to function as initial receptors in ABC transport of metal ions in some eubacterial species. They belong to the TroA superfamily of periplasmic metal binding proteins that share a distinct...; Region: FeuA; cd01138 508765006098 Periplasmic binding protein; Region: Peripla_BP_2; pfam01497 508765006099 putative ligand binding residues [chemical binding]; other site 508765006100 tRNA-dihydrouridine synthase [Translation, ribosomal structure and biogenesis]; Region: COG0042 508765006101 Dihydrouridine synthase-like (DUS-like) FMN-binding domain. Members of this family catalyze the reduction of the 5,6-double bond of a uridine residue on tRNA. Dihydrouridine modification of tRNA is widely observed in prokaryotes and eukaryotes, and also...; Region: DUS_like_FMN; cd02801 508765006102 FMN binding site [chemical binding]; other site 508765006103 active site 508765006104 catalytic residues [active] 508765006105 substrate binding site [chemical binding]; other site 508765006106 Zinc dependent phospholipase C (alpha toxin); Region: Zn_dep_PLPC; cd11009 508765006107 Zn binding site [ion binding]; other site 508765006108 Transcription elongation factor, N-terminal; Region: GreA_GreB_N; pfam03449 508765006109 transcription elongation factor GreA; Region: greA; TIGR01462 508765006110 Transcription elongation factor, GreA/GreB, C-term; Region: GreA_GreB; pfam01272 508765006111 Alpha amylase catalytic domain found in sucrose phosphorylase-like proteins (also called sucrose glucosyltransferase, disaccharide glucosyltransferase, and sucrose-phosphate alpha-D glucosyltransferase); Region: AmyAc_Sucrose_phosphorylase-like_1; cd11356 508765006112 sucrose phosphorylase; Region: sucrose_gtfA; TIGR03852 508765006113 active site 508765006114 homodimer interface [polypeptide binding]; other site 508765006115 catalytic site [active] 508765006116 alpha-mannosidase; Provisional; Region: PRK09819 508765006117 N-terminal catalytic domain of Escherichia coli alpha-mannosidase MngB and its bacterial homologs; glycoside hydrolase family 38 (GH38); Region: GH38N_AMII_EcMngB_like; cd10815 508765006118 active site 508765006119 metal binding site [ion binding]; metal-binding site 508765006120 catalytic site [active] 508765006121 Alpha mannosidase, middle domain; Region: Alpha-mann_mid; cl08536 508765006122 PTS system 2-O-a-mannosyl-D-glycerate specific transporter subunit IIABC; Provisional; Region: PRK09765 508765006123 PTS_IIA, PTS system, fructose/mannitol specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_fru; cd00211 508765006124 active site 508765006125 phosphorylation site [posttranslational modification] 508765006126 PTS_IIB_fructose: subunit IIB of enzyme II (EII) of the fructose-specific phosphoenolpyruvate:carbohydrate phosphotransferase system (PTS). In this system, EII (also referred to as FruAB) is a fructose-specific permease made up of two proteins (FruA and...; Region: PTS_IIB_fructose; cd05569 508765006127 active site 508765006128 P-loop; other site 508765006129 phosphorylation site [posttranslational modification] 508765006130 Phosphotransferase system, fructose-specific IIC component [Carbohydrate transport and metabolism]; Region: FruA; COG1299 508765006131 Transcriptional regulators [Transcription]; Region: RpiR; COG1737 508765006132 Helix-turn-helix domain, rpiR family; Region: HTH_6; pfam01418 508765006133 RpiR-like protein. RpiR contains a SIS (Sugar ISomerase) domain, which is found in many phosphosugar isomerases and phosphosugar binding proteins. In E. coli, rpiR negatively regulates the expression of rpiB gene. Both rpiB and rpiA are ribose phosphate...; Region: SIS_RpiR; cd05013 508765006134 putative active site [active] 508765006135 Chloramphenicol acetyltransferase; Region: CAT; cl02008 508765006136 Chloramphenicol O-acetyltransferase [Defense mechanisms]; Region: COG4845 508765006137 Alpha/beta hydrolase of unknown function (DUF1057); Region: DUF1057; pfam06342 508765006138 Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596 508765006139 TAP-like protein; Region: Abhydrolase_4; pfam08386 508765006140 Protein of unknown function (DUF3267); Region: DUF3267; pfam11667 508765006141 3-oxoacid CoA-transferase, B subunit; Region: pcaJ_scoB_fam; TIGR02428 508765006142 Coenzyme A transferase; Region: CoA_trans; cl17247 508765006143 Ethanolamine utilization protein EutE-like; Region: ALDH_EutE; cd07121 508765006144 Aldehyde dehydrogenase family; Region: Aldedh; pfam00171 508765006145 putative catalytic cysteine [active] 508765006146 acetoacetate decarboxylase; Provisional; Region: PRK02265 508765006147 Cysteine hydrolases; This family contains amidohydrolases, like CSHase (N-carbamoylsarcosine amidohydrolase), involved in creatine metabolism and nicotinamidase, converting nicotinamide to nicotinic acid and ammonia in the pyridine nucleotide cycle. It...; Region: cysteine_hydrolases; cd00431 508765006148 catalytic triad [active] 508765006149 conserved cis-peptide bond; other site 508765006150 Uncharacterized protein family (UPF0157); Region: UPF0157; pfam04229 508765006151 Acetyltransferase (GNAT) domain; Region: Acetyltransf_3; pfam13302 508765006152 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 508765006153 Coenzyme A binding pocket [chemical binding]; other site 508765006154 Protein of unknown function (DUF3795); Region: DUF3795; pfam12675 508765006155 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 508765006156 Acetyltransferases [General function prediction only]; Region: RimI; COG0456 508765006157 Coenzyme A binding pocket [chemical binding]; other site 508765006158 putative acetyltransferase YhhY; Provisional; Region: PRK10140 508765006159 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 508765006160 Coenzyme A binding pocket [chemical binding]; other site 508765006161 aromatic cluster surface protein; Region: aro_clust_Mycop; TIGR04313 508765006162 Bacillus subtilis YkuE and related proteins, C-terminal metallophosphatase domain; Region: MPP_YkuE_C; cd07385 508765006163 Calcineurin-like phosphoesterase; Region: Metallophos; pfam00149 508765006164 putative active site [active] 508765006165 putative metal binding site [ion binding]; other site 508765006166 BlaR1 peptidase M56; Region: Peptidase_M56; pfam05569 508765006167 stage II sporulation protein P; Region: spore_II_P; TIGR02867 508765006168 copper transport repressor, CopY/TcrY family; Region: CopY_TcrY; TIGR02698 508765006169 Penicillinase repressor; Region: Pencillinase_R; pfam03965 508765006170 Repair protein; Region: Repair_PSII; pfam04536 508765006171 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 508765006172 non-specific DNA binding site [nucleotide binding]; other site 508765006173 salt bridge; other site 508765006174 sequence-specific DNA binding site [nucleotide binding]; other site 508765006175 4-hydroxybenzoate polyprenyltransferase and related prenyltransferases [Coenzyme metabolism]; Region: UbiA; cl00337 508765006176 Nicotinamidase_ related amidohydrolases. Cysteine hydrolases of unknown function that share the catalytic triad with other amidohydrolases, like nicotinamidase, which converts nicotinamide to nicotinic acid and ammonia; Region: nicotinamidase_related; cd01014 508765006177 Isochorismatase family; Region: Isochorismatase; pfam00857 508765006178 catalytic triad [active] 508765006179 conserved cis-peptide bond; other site 508765006180 NADPH-dependent FMN reductase; Region: FMN_red; pfam03358 508765006181 Multimeric flavodoxin WrbA [General function prediction only]; Region: WrbA; COG0655 508765006182 Acetyltransferase (GNAT) domain; Region: Acetyltransf_3; pfam13302 508765006183 Acetyltransferase (GNAT) family; Region: Acetyltransf_1; pfam00583 508765006184 Flavodoxin domain; Region: Flavodoxin_5; cl17428 508765006185 RPB11 and RPB3 subunits of RNA polymerase; Region: RNAP_RPB11_RPB3; cl11409 508765006186 4Fe-4S dicluster domain; Region: Fer4_7; pfam12838 508765006187 maltose O-acetyltransferase; Provisional; Region: PRK10092 508765006188 Maltose O-acetyltransferase (MAT) and Galactoside O-acetyltransferase (GAT): MAT and GAT catalyze the CoA-dependent acetylation of the 6-hydroxyl group of their respective sugar substrates. MAT acetylates maltose and glucose exclusively at the C6...; Region: LbH_MAT_GAT; cd03357 508765006189 active site 508765006190 substrate binding site [chemical binding]; other site 508765006191 trimer interface [polypeptide binding]; other site 508765006192 CoA binding site [chemical binding]; other site 508765006193 Chloramphenicol O-acetyltransferase [Defense mechanisms]; Region: COG4845 508765006194 Chloramphenicol acetyltransferase; Region: CAT; smart01059 508765006195 Carboxymuconolactone decarboxylase family; Region: CMD; cl00460 508765006196 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 508765006197 topology modulation protein; Provisional; Region: PRK07261 508765006198 AAA domain; Region: AAA_17; pfam13207 508765006199 Beta-lactamase class C and other penicillin binding proteins [Defense mechanisms]; Region: AmpC; COG1680 508765006200 Beta-lactamase; Region: Beta-lactamase; pfam00144 508765006201 Peptidase MA superfamily; Region: Peptidase_MA_2; pfam13485 508765006202 Catalytic domain of phospholipase D superfamily proteins; Region: PLDc_SF; cl15239 508765006203 PLD-like domain; Region: PLDc_2; pfam13091 508765006204 putative active site [active] 508765006205 catalytic site [active] 508765006206 Catalytic domain of phospholipase D superfamily proteins; Region: PLDc_SF; cl15239 508765006207 PLD-like domain; Region: PLDc_2; pfam13091 508765006208 putative active site [active] 508765006209 catalytic site [active] 508765006210 The family 20 carbohydrate-binding module (CBM20), also known as the starch-binding domain, is found in a large number of starch degrading enzymes including alpha-amylase, beta-amylase, glucoamylase, and CGTase (cyclodextrin glucanotransferase). CBM20 is...; Region: CBM20; cd05467 508765006211 starch-binding site 2 [chemical binding]; other site 508765006212 starch-binding site 1 [chemical binding]; other site 508765006213 Phosphatidylserine/phosphatidylglycerophosphate/car diolipin synthases and related enzymes [Lipid metabolism]; Region: Cls; COG1502 508765006214 Catalytic domain of phospholipase D superfamily proteins; Region: PLDc_SF; cl15239 508765006215 putative active site [active] 508765006216 catalytic site [active] 508765006217 Catalytic domain of phospholipase D superfamily proteins; Region: PLDc_SF; cl15239 508765006218 PLD-like domain; Region: PLDc_2; pfam13091 508765006219 putative active site [active] 508765006220 catalytic site [active] 508765006221 The family 20 carbohydrate-binding module (CBM20), also known as the starch-binding domain, is found in a large number of starch degrading enzymes including alpha-amylase, beta-amylase, glucoamylase, and CGTase (cyclodextrin glucanotransferase). CBM20 is...; Region: CBM20; cd05467 508765006222 starch-binding site 2 [chemical binding]; other site 508765006223 starch-binding site 1 [chemical binding]; other site 508765006224 Flavodoxin domain; Region: Flavodoxin_5; pfam12724 508765006225 This domain superfamily is found in a variety of structurally related metalloproteins, including the type I extradiol dioxygenases, glyoxalase I and a group of antibiotic resistance proteins; Region: Glo_EDI_BRP_like; cl14632 508765006226 Acetyltransferase (GNAT) domain; Region: Acetyltransf_3; pfam13302 508765006227 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 508765006228 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl17182 508765006229 Coenzyme A binding pocket [chemical binding]; other site 508765006230 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 508765006231 Coenzyme A binding pocket [chemical binding]; other site 508765006232 Uncharacterized protein conserved in bacteria (DUF2262); Region: DUF2262; cl01757 508765006233 Polypeptide or peptide deformylase; a family of metalloenzymes that catalyzes the removal of the N-terminal formyl group in a growing polypeptide chain following translation initiation during protein synthesis in prokaryotes. These enzymes utilize Fe(II)...; Region: Pep_deformylase; cd00487 508765006234 active site 508765006235 catalytic residues [active] 508765006236 metal binding site [ion binding]; metal-binding site 508765006237 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 508765006238 non-specific DNA binding site [nucleotide binding]; other site 508765006239 salt bridge; other site 508765006240 sequence-specific DNA binding site [nucleotide binding]; other site 508765006241 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 508765006242 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl17182 508765006243 Coenzyme A binding pocket [chemical binding]; other site 508765006244 Domain of unknown function (DUF4303); Region: DUF4303; pfam14136 508765006245 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 508765006246 dimerization interface [polypeptide binding]; other site 508765006247 putative DNA binding site [nucleotide binding]; other site 508765006248 putative Zn2+ binding site [ion binding]; other site 508765006249 Protein of unknown function (DUF1648); Region: DUF1648; pfam07853 508765006250 Predicted integral membrane protein [Function unknown]; Region: COG5658 508765006251 SdpI/YhfL protein family; Region: SdpI; pfam13630 508765006252 Kef-type K+ transport systems, membrane components [Inorganic ion transport and metabolism]; Region: KefB; COG0475 508765006253 Sodium/hydrogen exchanger family; Region: Na_H_Exchanger; pfam00999 508765006254 Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805 508765006255 Pentapeptide repeats (9 copies); Region: Pentapeptide_4; pfam13599 508765006256 Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805 508765006257 Cache domain; Region: Cache_1; pfam02743 508765006258 HAMP domain; Region: HAMP; pfam00672 508765006259 Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer); Region: MA; smart00283 508765006260 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 508765006261 dimer interface [polypeptide binding]; other site 508765006262 putative CheW interface [polypeptide binding]; other site 508765006263 Domain of unknown function (DUF4179); Region: DUF4179; pfam13786 508765006264 RNA polymerase factor sigma-70; Validated; Region: PRK06811 508765006265 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 508765006266 Sigma-70, region 4; Region: Sigma70_r4_2; pfam08281 508765006267 DNA binding residues [nucleotide binding] 508765006268 Membrane protein involved in the export of O-antigen and teichoic acid [General function prediction only]; Region: RfbX; COG2244 508765006269 Wzx, a subfamily of the multidrug and toxic compound extrusion (MATE)-like proteins; Region: MATE_Wzx_like; cd13128 508765006270 Domain of unknown function (DUF4179); Region: DUF4179; pfam13786 508765006271 Domain of unknown function (DUF4179); Region: DUF4179; pfam13786 508765006272 Flavodoxin-like fold; Region: Flavodoxin_2; cl00438 508765006273 TIGR04076 family protein; Region: TIGR04076 508765006274 ABC-2 family transporter protein; Region: ABC2_membrane_4; pfam12730 508765006275 ABC-type multidrug transport system, ATPase component [Defense mechanisms]; Region: CcmA; COG1131 508765006276 ABC-type multidrug transport system, ATPase component; Region: ABC_drug_resistance_like; cd03264 508765006277 Walker A/P-loop; other site 508765006278 ATP binding site [chemical binding]; other site 508765006279 Q-loop/lid; other site 508765006280 ABC transporter signature motif; other site 508765006281 Walker B; other site 508765006282 D-loop; other site 508765006283 H-loop/switch region; other site 508765006284 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 508765006285 His Kinase A (phospho-acceptor) domain; Region: HisKA; pfam00512 508765006286 phosphorylation site [posttranslational modification] 508765006287 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 508765006288 ATP binding site [chemical binding]; other site 508765006289 Mg2+ binding site [ion binding]; other site 508765006290 G-X-G motif; other site 508765006291 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 508765006292 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 508765006293 active site 508765006294 phosphorylation site [posttranslational modification] 508765006295 intermolecular recognition site; other site 508765006296 dimerization interface [polypeptide binding]; other site 508765006297 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 508765006298 DNA binding site [nucleotide binding] 508765006299 lantibiotic protection ABC transporter permease subunit, MutG family; Region: lanti_perm_MutG; TIGR03733 508765006300 ABC-2 family transporter protein; Region: ABC2_membrane_4; pfam12730 508765006301 lantibiotic protection ABC transporter permease subunit, MutE/EpiE family; Region: lanti_perm_MutE; TIGR03732 508765006302 gallidermin-class lantibiotic protection ABC transporter, ATP-binding subunit; Region: galliderm_ABC; TIGR03740 508765006303 ATP-binding cassette domain of the bacitracin-resistance transporter; Region: ABC_BcrA_bacitracin_resist; cd03268 508765006304 Walker A/P-loop; other site 508765006305 ATP binding site [chemical binding]; other site 508765006306 Q-loop/lid; other site 508765006307 ABC transporter signature motif; other site 508765006308 Walker B; other site 508765006309 D-loop; other site 508765006310 H-loop/switch region; other site 508765006311 Protein of unknown function DUF45; Region: DUF45; pfam01863 508765006312 Flavodoxin-like fold; Region: Flavodoxin_2; cl00438 508765006313 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3883 508765006314 Cell wall-associated hydrolases (invasion-associated proteins) [Cell envelope biogenesis, outer membrane]; Region: Spr; COG0791 508765006315 NlpC/P60 family; Region: NLPC_P60; pfam00877 508765006316 Predicted thioesterase [General function prediction only]; Region: COG5496 508765006317 Der1-like family; Region: DER1; cl17806 508765006318 RNA polymerase sigma factor, sigma-70 family; Region: sigma70-ECF; TIGR02937 508765006319 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 508765006320 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 508765006321 DNA binding residues [nucleotide binding] 508765006322 phosphoribosylpyrophosphate synthetase; Provisional; Region: PRK06827 508765006323 N-terminal domain of ribose phosphate pyrophosphokinase; Region: Pribosyltran_N; pfam13793 508765006324 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 508765006325 active site 508765006326 50S ribosomal protein L25/general stress protein Ctc; Reviewed; Region: PRK05618 508765006327 Ribosomal L25/TL5/CTC N-terminal 5S rRNA binding domain; Region: Ribosomal_L25_TL5_CTC; cd00495 508765006328 5S rRNA interface [nucleotide binding]; other site 508765006329 CTC domain interface [polypeptide binding]; other site 508765006330 L16 interface [polypeptide binding]; other site 508765006331 50S ribosomal protein L25/general stress protein Ctc; Reviewed; Region: PRK05618 508765006332 Ribosomal L25/TL5/CTC N-terminal 5S rRNA binding domain; Region: Ribosomal_L25_TL5_CTC; cd00495 508765006333 5S rRNA interface [nucleotide binding]; other site 508765006334 CTC domain interface [polypeptide binding]; other site 508765006335 L16 interface [polypeptide binding]; other site 508765006336 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 508765006337 ATP binding site [chemical binding]; other site 508765006338 Superfamily II DNA and RNA helicases [DNA replication, recombination, and repair / Transcription / Translation, ribosomal structure and biogenesis]; Region: SrmB; COG0513 508765006339 putative Mg++ binding site [ion binding]; other site 508765006340 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 508765006341 nucleotide binding region [chemical binding]; other site 508765006342 ATP-binding site [chemical binding]; other site 508765006343 Mitochondrial degradasome RNA helicase subunit C terminal; Region: SUV3_C; pfam12513 508765006344 Domain of unknown function (DUF4163); Region: DUF4163; pfam13739 508765006345 Protein of unknown function (DUF3298); Region: DUF3298; pfam11738 508765006346 3-dehydroquinate dehydratase [Amino acid transport and metabolism]; Region: AroD; COG0710 508765006347 Type I 3-dehydroquinase, (3-dehydroquinate dehydratase or DHQase); Region: DHQase_I; cd00502 508765006348 active site 508765006349 catalytic residue [active] 508765006350 dimer interface [polypeptide binding]; other site 508765006351 M20 Peptidase T specifically cleaves tripeptides; Region: M20_peptT; cd03892 508765006352 peptidase T; Region: peptidase-T; TIGR01882 508765006353 metal binding site [ion binding]; metal-binding site 508765006354 dimer interface [polypeptide binding]; other site 508765006355 Protein of unknown function (DUF342); Region: DUF342; pfam03961 508765006356 FOG: Glucan-binding domain (YG repeat) [General function prediction only]; Region: COG5263 508765006357 Bacterial SH3 domain; Region: SH3_3; pfam08239 508765006358 Surface antigen [General function prediction only]; Region: COG3942 508765006359 CHAP domain; Region: CHAP; pfam05257 508765006360 SnoaL-like domain; Region: SnoaL_3; pfam13474 508765006361 PAS domain S-box; Region: sensory_box; TIGR00229 508765006362 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 508765006363 putative active site [active] 508765006364 heme pocket [chemical binding]; other site 508765006365 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 508765006366 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 508765006367 metal binding site [ion binding]; metal-binding site 508765006368 active site 508765006369 I-site; other site 508765006370 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 508765006371 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 508765006372 metal binding site [ion binding]; metal-binding site 508765006373 active site 508765006374 I-site; other site 508765006375 EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2). The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948 508765006376 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 508765006377 PAS domain; Region: PAS_9; pfam13426 508765006378 putative active site [active] 508765006379 heme pocket [chemical binding]; other site 508765006380 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 508765006381 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 508765006382 metal binding site [ion binding]; metal-binding site 508765006383 active site 508765006384 I-site; other site 508765006385 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 508765006386 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 508765006387 metal binding site [ion binding]; metal-binding site 508765006388 active site 508765006389 I-site; other site 508765006390 EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2). The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948 508765006391 This is a subfamily of Adenine nucleotide alpha hydrolases superfamily.Adeninosine nucleotide alpha hydrolases superfamily includes N type ATP PPases and ATP sulphurylases. It forms a apha/beta/apha fold which binds to Adenosine group. This subfamily; Region: Alpha_ANH_like_II; cd01993 508765006392 Ligand Binding Site [chemical binding]; other site 508765006393 putative DNA-binding transcriptional regulator; Reviewed; Region: PRK00347 508765006394 Helix-turn-helix domain; Region: HTH_36; pfam13730 508765006395 Ribbon-helix-helix domain; Region: RHH_3; pfam12651 508765006396 LexA DNA binding domain; Region: LexA_DNA_bind; pfam01726 508765006397 lysozyme_like domain. This contains several members including Soluble Lytic Transglycosylases (SLT), Goose Egg-White Lysozymes (GEWL), Hen Egg-White Lysozymes (HEWL), chitinases, bacteriophage lambda lysozymes, endolysins, autolysins, and chitosanases; Region: lysozyme_like; cl00222 508765006398 catalytic residue [active] 508765006399 Haemolysin XhlA; Region: XhlA; pfam10779 508765006400 chromosome segregation protein SMC, common bacterial type; Region: SMC_prok_B; TIGR02168 508765006401 Prophage endopeptidase tail; Region: Prophage_tail; cl12123 508765006402 Phage-related protein [Function unknown]; Region: COG4722 508765006403 Phage tail protein; Region: Sipho_tail; cl17486 508765006404 Phage tail protein; Region: Sipho_tail; cl17486 508765006405 Phage-related minor tail protein; Region: PhageMin_Tail; pfam10145 508765006406 Phage-related protein [Function unknown]; Region: COG5412 508765006407 membrane protein P6; Region: PHA01399 508765006408 Phage capsid family; Region: Phage_capsid; pfam05065 508765006409 Caseinolytic protease (ClpP) is an ATP-dependent, highly conserved serine protease; Region: S14_ClpP_1; cd07016 508765006410 oligomer interface [polypeptide binding]; other site 508765006411 Clp protease; Region: CLP_protease; pfam00574 508765006412 active site residues [active] 508765006413 phage portal protein, HK97 family; Region: portal_HK97; TIGR01537 508765006414 Phage terminase-like protein, large subunit [General function prediction only]; Region: COG4626 508765006415 HNH nucleases; HNH endonuclease signature which is found in viral, prokaryotic, and eukaryotic proteins. The alignment includes members of the large group of homing endonucleases, yeast intron 1 protein, MutS, as well as bacterial colicins, pyocins, and...; Region: HNHc; cl00083 508765006416 Coat F domain; Region: Coat_F; pfam07875 508765006417 Manganese catalase, ferritin-like diiron-binding domain; Region: Mn_catalase; cd01051 508765006418 Uncharacterized conserved protein [Function unknown]; Region: COG1633 508765006419 dimanganese center [ion binding]; other site 508765006420 Domain of Unknown Function with PDB structure (DUF3850); Region: DUF3850; pfam12961 508765006421 Single-stranded DNA-binding protein [DNA replication, recombination, and repair]; Region: Ssb; COG0629 508765006422 SSB_OBF: A subfamily of OB folds similar to the OB fold of ssDNA-binding protein (SSB). SSBs bind with high affinity to ssDNA. They bind to and protect ssDNA intermediates during DNA metabolic pathways. All bacterial and eukaryotic SSBs studied to date...; Region: SSB_OBF; cd04496 508765006423 dimer interface [polypeptide binding]; other site 508765006424 ssDNA binding site [nucleotide binding]; other site 508765006425 tetramer (dimer of dimers) interface [polypeptide binding]; other site 508765006426 ParB/RepB/Spo0J family partition protein; Region: parB_part; TIGR00180 508765006427 ParB-like nuclease domain; Region: ParBc; pfam02195 508765006428 ATPases involved in chromosome partitioning [Cell division and chromosome partitioning]; Region: Soj; COG1192 508765006429 ParA and ParB of Caulobacter crescentus belong to a conserved family of bacterial proteins implicated in chromosome segregation. ParB binds to DNA sequences adjacent to the origin of replication and localizes to opposite cell poles shortly following the...; Region: ParA; cd02042 508765006430 P-loop; other site 508765006431 Magnesium ion binding site [ion binding]; other site 508765006432 ParA and ParB of Caulobacter crescentus belong to a conserved family of bacterial proteins implicated in chromosome segregation. ParB binds to DNA sequences adjacent to the origin of replication and localizes to opposite cell poles shortly following the...; Region: ParA; cd02042 508765006433 Magnesium ion binding site [ion binding]; other site 508765006434 YopX protein; Region: YopX; cl09859 508765006435 VRR-NUC domain; Region: VRR_NUC; pfam08774 508765006436 putative replication initiation protein; Region: PHA00330 508765006437 Spo0E like sporulation regulatory protein; Region: SpoOE-like; pfam09388 508765006438 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 508765006439 non-specific DNA binding site [nucleotide binding]; other site 508765006440 salt bridge; other site 508765006441 sequence-specific DNA binding site [nucleotide binding]; other site 508765006442 YcfA-like protein; Region: YcfA; pfam07927 508765006443 Predicted nuclease of the RNAse H fold, HicB family [General function prediction only]; Region: COG1598 508765006444 Site-specific recombinases, DNA invertase Pin homologs [DNA replication, recombination, and repair]; Region: PinR; COG1961 508765006445 Serine Recombinase family, catalytic domain; a DNA binding domain may be present either N- or C-terminal to the catalytic domain. These enzymes perform site-specific recombination of DNA molecules by a concerted, four-strand cleavage and rejoining...; Region: Ser_Recombinase; cd00338 508765006446 catalytic residues [active] 508765006447 catalytic nucleophile [active] 508765006448 Recombinase; Region: Recombinase; pfam07508 508765006449 Recombinase zinc beta ribbon domain; Region: Zn_ribbon_recom; pfam13408 508765006450 Sugar fermentation stimulation protein; Region: SfsA; cl00647 508765006451 Protein-tyrosine-phosphatase [Signal transduction mechanisms]; Region: Wzb; COG0394 508765006452 Low molecular weight phosphatase family; Region: LMWPc; cl00105 508765006453 active site 508765006454 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 508765006455 dimerization interface [polypeptide binding]; other site 508765006456 putative DNA binding site [nucleotide binding]; other site 508765006457 putative Zn2+ binding site [ion binding]; other site 508765006458 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 508765006459 Coenzyme A binding pocket [chemical binding]; other site 508765006460 Probable zinc-binding domain; Region: zf-trcl; pfam13451 508765006461 PTS system 2-O-a-mannosyl-D-glycerate specific transporter subunit IIABC; Provisional; Region: PRK09765 508765006462 PTS_IIA, PTS system, fructose/mannitol specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_fru; cd00211 508765006463 active site 508765006464 phosphorylation site [posttranslational modification] 508765006465 PTS_IIB_fructose: subunit IIB of enzyme II (EII) of the fructose-specific phosphoenolpyruvate:carbohydrate phosphotransferase system (PTS). In this system, EII (also referred to as FruAB) is a fructose-specific permease made up of two proteins (FruA and...; Region: PTS_IIB_fructose; cd05569 508765006466 active site 508765006467 P-loop; other site 508765006468 phosphorylation site [posttranslational modification] 508765006469 Phosphotransferase system, fructose-specific IIC component [Carbohydrate transport and metabolism]; Region: FruA; COG1299 508765006470 Fructose-1-phosphate kinase and related fructose-6-phosphate kinase (PfkB) [Carbohydrate transport and metabolism]; Region: FruK; COG1105 508765006471 1-phosphofructokinase (FruK), minor 6-phosphofructokinase (pfkB) and related sugar kinases. FruK plays an important role in the predominant pathway for fructose utilisation.This group also contains tagatose-6-phophate kinase, an enzyme of the tagatose...; Region: FruK_PfkB_like; cd01164 508765006472 putative substrate binding site [chemical binding]; other site 508765006473 putative ATP binding site [chemical binding]; other site 508765006474 Transcriptional regulators of sugar metabolism [Transcription / Carbohydrate transport and metabolism]; Region: GlpR; COG1349 508765006475 helix_turn_helix, Deoxyribose operon repressor; Region: HTH_DEOR; smart00420 508765006476 DeoR C terminal sensor domain; Region: DeoRC; pfam00455 508765006477 ECF-type riboflavin transporter, S component; Region: ECF-ribofla_trS; pfam07155 508765006478 Polymerase and Histidinol Phosphatase domain of Histidinol phosphate phosphatase (HisPPase) AMP bound; Region: PHP_HisPPase_AMP; cd07438 508765006479 DNA polymerase alpha chain like domain; Region: POLIIIAc; smart00481 508765006480 active site 508765006481 Uncharacterized subfamily of the multidrug and toxic compound extrusion (MATE) proteins; Region: MATE_like_8; cd13134 508765006482 Na+-driven multidrug efflux pump [Defense mechanisms]; Region: NorM; COG0534 508765006483 RNA polymerase factor sigma-70; Validated; Region: PRK06811 508765006484 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cl17257 508765006485 L-ascorbate oxidase; Region: PLN02191 508765006486 Inorganic pyrophosphatase. These enzymes hydrolyze inorganic pyrophosphate (PPi) to two molecules of orthophosphates (Pi). The reaction requires bivalent cations. The enzymes in general exist as homooligomers; Region: pyrophosphatase; cl00217 508765006487 Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067 508765006488 catalytic core [active] 508765006489 2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207 508765006490 catalytic loop [active] 508765006491 iron binding site [ion binding]; other site 508765006492 NADH-ubiquinone oxidoreductase-G iron-sulfur binding region; Region: NADH-G_4Fe-4S_3; pfam10588 508765006493 The HCP family of iron-sulfur proteins includes hybrid cluster protein (HCP), acetyl-CoA synthase (ACS), and carbon monoxide dehydrogenase (CODH), all of which contain [Fe4-S4] metal clusters at their active sites. These proteins have a conserved...; Region: HCP_like; cl14655 508765006494 [FeFe] hydrogenase, group A; Region: FeFe_hydrog_A; TIGR02512 508765006495 Iron only hydrogenase large subunit, C-terminal domain; Region: Fe_hyd_lg_C; pfam02906 508765006496 Iron hydrogenase small subunit; Region: Fe_hyd_SSU; pfam02256 508765006497 Thioredoxin (TRX)-like [2Fe-2S] Ferredoxin (Fd) family; composed of [2Fe-2S] Fds with a TRX fold (TRX-like Fds) and proteins containing domains similar to TRX-like Fd including formate dehydrogenases, NAD-reducing hydrogenases and the subunit E of NADH:...; Region: TRX_Fd_family; cd02980 508765006498 dimer interface [polypeptide binding]; other site 508765006499 [2Fe-2S] cluster binding site [ion binding]; other site 508765006500 NADH:ubiquinone oxidoreductase, NADH-binding (51 kD) subunit [Energy production and conversion]; Region: NuoF; COG1894 508765006501 SLBB domain; Region: SLBB; pfam10531 508765006502 NADH-ubiquinone oxidoreductase-F iron-sulfur binding region; Region: NADH_4Fe-4S; smart00928 508765006503 4Fe-4S binding domain; Region: Fer4; pfam00037 508765006504 4Fe-4S dicluster domain; Region: Fer4_10; pfam13237 508765006505 4Fe-4S binding domain; Region: Fer4; cl02805 508765006506 Respiratory-chain NADH dehydrogenase 24 Kd subunit; Region: Complex1_24kDa; pfam01257 508765006507 TRX-like [2Fe-2S] Ferredoxin (Fd) family, NADH:ubiquinone oxidoreductase (Nuo) subunit E subfamily; Nuo, also called respiratory chain Complex 1, is the entry point for electrons into the respiratory chains of bacteria and the mitochondria of eukaryotes; Region: TRX_Fd_NuoE; cd03064 508765006508 putative dimer interface [polypeptide binding]; other site 508765006509 [2Fe-2S] cluster binding site [ion binding]; other site 508765006510 cardiolipin synthase; Region: bac_cardiolipin; TIGR04265 508765006511 Catalytic domain, repeat 1, of bacterial cardiolipin synthase and similar proteins; Region: PLDc_CLS_1; cd09110 508765006512 putative active site [active] 508765006513 catalytic site [active] 508765006514 catalytic domain repeat 2 of bacterial cardiolipin synthase and similar proteins; Region: PLDc_CLS_2; cd09112 508765006515 putative active site [active] 508765006516 catalytic site [active] 508765006517 Domain of unknown function DUF20; Region: UPF0118; pfam01594 508765006518 Predicted permease, member of the PurR regulon [General function prediction only]; Region: yhhT; COG0628 508765006519 Lysophospholipase [Lipid metabolism]; Region: PldB; COG2267 508765006520 Putative lysophospholipase; Region: Hydrolase_4; pfam12146 508765006521 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 508765006522 Coenzyme A binding pocket [chemical binding]; other site 508765006523 arginine:agmatin antiporter; Provisional; Region: PRK10644 508765006524 Protein of unknown function (DUF1097); Region: DUF1097; pfam06496 508765006525 dihydropyrimidine dehydrogenase subunit B; Validated; Region: PRK08318 508765006526 Dihydropyrimidine dehydrogenase (DHPD) FMN-binding domain. DHPD catalyzes the first step in pyrimidine degradation: the NADPH-dependent reduction of uracil and thymine to the corresponding 5,6-dihydropyrimidines. DHPD contains two FAD, two FMN, and...; Region: DHPD_FMN; cd02940 508765006527 homodimer interface [polypeptide binding]; other site 508765006528 active site 508765006529 FMN binding site [chemical binding]; other site 508765006530 substrate binding site [chemical binding]; other site 508765006531 4Fe-4S binding domain; Region: Fer4; cl02805 508765006532 4Fe-4S binding domain; Region: Fer4; pfam00037 508765006533 dihydropyrimidine dehydrogenase subunit A; Provisional; Region: PRK11749 508765006534 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450 508765006535 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 508765006536 Anti-sigma factor N-terminus; Region: RsgI_N; pfam12791 508765006537 putative RNA polymerase sigma factor SigI; Reviewed; Region: PRK08311 508765006538 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 508765006539 Uncharacterized conserved protein [Function unknown]; Region: COG3391 508765006540 Protein of unknown function (DUF3343); Region: DUF3343; pfam11823 508765006541 Zn-ribbon protein, possibly nucleic acid-binding [General function prediction only]; Region: COG1579 508765006542 UDP-glucose LOS-beta-1,4 glucosyltransferase is required for biosynthesis of lipooligosaccharide; Region: Beta4Glucosyltransferase; cd02511 508765006543 putative metal binding site; other site 508765006544 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 508765006545 TPR motif; other site 508765006546 binding surface 508765006547 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 508765006548 binding surface 508765006549 TPR motif; other site 508765006550 lipopolysaccharide biosynthesis protein RfbH; Provisional; Region: PRK15407 508765006551 3-amino-5-hydroxybenzoic acid synthase family (AHBA_syn). AHBA_syn family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The members of this CD are involved in various biosynthetic pathways for secondary...; Region: AHBA_syn; cd00616 508765006552 inhibitor-cofactor binding pocket; inhibition site 508765006553 pyridoxal 5'-phosphate binding site [chemical binding]; other site 508765006554 catalytic residue [active] 508765006555 Predicted glycosyltransferases [General function prediction only]; Region: COG1216 508765006556 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394 508765006557 active site 508765006558 Nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: WcaG; COG0451 508765006559 extended (e) SDRs; Region: SDR_e; cd08946 508765006560 NAD(P) binding site [chemical binding]; other site 508765006561 active site 508765006562 substrate binding site [chemical binding]; other site 508765006563 methyltransferase, FkbM family; Region: fkbM_fam; TIGR01444 508765006564 methyltransferase, FkbM family; Region: fkbM_fam; TIGR01444 508765006565 Methyltransferase domain; Region: Methyltransf_24; pfam13578 508765006566 Thiamine pyrophosphate-requiring enzymes [acetolactate synthase, pyruvate dehydrogenase (cytochrome), glyoxylate carboligase, phosphonopyruvate decarboxylase] [Amino acid transport and metabolism / Coenzyme metabolism]; Region: IlvB; COG0028 508765006567 Pyrimidine (PYR) binding domain of POX and related proteins; Region: TPP_PYR_POX_like; cd07035 508765006568 PYR/PP interface [polypeptide binding]; other site 508765006569 dimer interface [polypeptide binding]; other site 508765006570 TPP binding site [chemical binding]; other site 508765006571 Thiamine pyrophosphate enzyme, central domain; Region: TPP_enzyme_M; pfam00205 508765006572 Thiamine pyrophosphate (TPP) enzyme family, TPP-binding module; found in many key metabolic enzymes which use TPP (also known as thiamine diphosphate) as a cofactor. These enzymes include, among others, the E1 components of the pyruvate, the acetoin and...; Region: TPP_enzymes; cd00568 508765006573 TPP-binding site [chemical binding]; other site 508765006574 haloacid dehalogenase-like hydrolase; Region: HAD; cl17202 508765006575 Phosphoheptose isomerase is a member of the SIS (Sugar ISomerase) superfamily. Phosphoheptose isomerase catalyzes the isomerization of sedoheptulose 7-phosphate into D-glycero-D-mannoheptose 7-phosphate. This is the first step of the biosynthesis of...; Region: SIS_GmhA; cd05006 508765006576 dimer interface [polypeptide binding]; other site 508765006577 active site 508765006578 NeuB family; Region: NeuB; pfam03102 508765006579 CDP-glucose 4,6-dehydratase; Region: CDP_4_6_dhtase; TIGR02622 508765006580 CDP-D-glucose 4,6-dehydratase, extended (e) SDRs; Region: CDP_GD_SDR_e; cd05252 508765006581 NAD binding site [chemical binding]; other site 508765006582 homotetramer interface [polypeptide binding]; other site 508765006583 homodimer interface [polypeptide binding]; other site 508765006584 substrate binding site [chemical binding]; other site 508765006585 active site 508765006586 Nucleoside-diphosphate-sugar pyrophosphorylase involved in lipopolysaccharide biosynthesis/translation initiation factor 2B, gamma/epsilon subunits (eIF-2Bgamma/eIF-2Bepsilon) [Cell envelope biogenesis, outer membrane / Translation, ribosomal structure...; Region: GCD1; COG1208 508765006587 G1P_cytidylyltransferase catalyzes the production of CDP-D-Glucose; Region: G1P_cytidylyltransferase; cd02524 508765006588 substrate binding site; other site 508765006589 Monoamine oxidase [Amino acid transport and metabolism]; Region: COG1231 508765006590 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450 508765006591 Selenocysteine lyase/Cysteine desulfurase [Posttranslational modification, protein turnover, chaperones]; Region: csdA; COG0520 508765006592 Cysteine desulfurase (SufS)-like. This family belongs to the pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to cysteine desulfurase (SufS) and selenocysteine lyase. SufS...; Region: SufS_like; cd06453 508765006593 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 508765006594 catalytic residue [active] 508765006595 tail sheath protein; Provisional; Region: 18; PHA02539 508765006596 Domain of unknown function DUF11; Region: DUF11; pfam01345 508765006597 fimbrial isopeptide formation D2 domain; Region: RrgB_K2N_iso_D2; TIGR04226 508765006598 fimbrial isopeptide formation D2 domain; Region: RrgB_K2N_iso_D2; TIGR04226 508765006599 Bacterial SNF2 helicase associated; Region: SNF2_assoc; pfam08455 508765006600 SNF2 family N-terminal domain; Region: SNF2_N; pfam00176 508765006601 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 508765006602 ATP binding site [chemical binding]; other site 508765006603 putative Mg++ binding site [ion binding]; other site 508765006604 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 508765006605 nucleotide binding region [chemical binding]; other site 508765006606 ATP-binding site [chemical binding]; other site 508765006607 DnaJ domain or J-domain. DnaJ/Hsp40 (heat shock protein 40) proteins are highly conserved and play crucial roles in protein translation, folding, unfolding, translocation, and degradation. They act primarily by stimulating the ATPase activity of Hsp70s; Region: DnaJ; cd06257 508765006608 HSP70 interaction site [polypeptide binding]; other site 508765006609 ATP-dependent DNA helicase RecQ; Region: recQ; TIGR01389 508765006610 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 508765006611 ATP binding site [chemical binding]; other site 508765006612 putative Mg++ binding site [ion binding]; other site 508765006613 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 508765006614 nucleotide binding region [chemical binding]; other site 508765006615 ATP-binding site [chemical binding]; other site 508765006616 This DNA-binding domain is found in the RecQ helicase among others and has a helix-turn-helix structure; Region: RQC; smart00956 508765006617 HRDC domain; Region: HRDC; pfam00570 508765006618 HRDC domain; Region: HRDC; pfam00570 508765006619 Lyc muramidase is an autolytic lysozyme (autolysin) from Clostridium acetobutylicum encoded by the lyc gene. Lyc has a glycosyl hydrolase family 25 (GH25) catalytic domain. Endo-N-acetylmuramidases are lysozymes (also referred to as peptidoglycan...; Region: GH25_Lyc-like; cd06525 508765006620 Glycosyl hydrolases family 25; Region: Glyco_hydro_25; pfam01183 508765006621 active site 508765006622 DmpA/OAT superfamily; composed of L-aminopeptidase D-amidase/D-esterase (DmpA), ornithine acetyltransferase (OAT) and similar proteins. DmpA is an aminopeptidase that releases N-terminal D and L amino acids from peptide substrates. This group represents...; Region: DmpA_OAT; cl00603 508765006623 Uncharacterized protein with SCP/PR1 domains [Function unknown]; Region: COG2340 508765006624 SCP_bacterial: SCP-like extracellular protein domain, as found in bacteria and archaea. The wider family of SCP containing proteins includes plant pathogenesis-related protein 1 (PR-1), CRISPs, mammalian cysteine-rich secretory proteins, and allergen 5...; Region: SCP_bacterial; cd05379 508765006625 pyruvate:ferredoxin (flavodoxin) oxidoreductase, homodimeric; Region: pyruv_ox_red; TIGR02176 508765006626 Pyrimidine (PYR) binding domain of pyruvate ferredoxin oxidoreductase (PFOR), indolepyruvate ferredoxin oxidoreductase alpha subunit (IOR-alpha), and related proteins; Region: TPP_PYR_PFOR_IOR-alpha_like; cd07034 508765006627 dimer interface [polypeptide binding]; other site 508765006628 PYR/PP interface [polypeptide binding]; other site 508765006629 TPP binding site [chemical binding]; other site 508765006630 substrate binding site [chemical binding]; other site 508765006631 Pyruvate:ferredoxin oxidoreductase and related 2-oxoacid:ferredoxin oxidoreductases, gamma subunit [Energy production and conversion]; Region: PorG; COG1014 508765006632 Domain of unknown function; Region: EKR; pfam10371 508765006633 4Fe-4S binding domain; Region: Fer4_6; pfam12837 508765006634 The HCP family of iron-sulfur proteins includes hybrid cluster protein (HCP), acetyl-CoA synthase (ACS), and carbon monoxide dehydrogenase (CODH), all of which contain [Fe4-S4] metal clusters at their active sites. These proteins have a conserved...; Region: HCP_like; cl14655 508765006635 Thiamine pyrophosphate (TPP family), PFOR_PNO subfamily, TPP-binding module; composed of proteins similar to the single subunit pyruvate ferredoxin oxidoreductase (PFOR) of Desulfovibrio Africanus, present in bacteria and amitochondriate eukaryotes. This...; Region: TPP_PFOR_PNO; cd03377 508765006636 TPP-binding site [chemical binding]; other site 508765006637 dimer interface [polypeptide binding]; other site 508765006638 glycerate kinase; Region: TIGR00045 508765006639 H+/gluconate symporter and related permeases [Carbohydrate transport and metabolism / Amino acid transport and metabolism]; Region: GntT; COG2610 508765006640 fructuronate transporter; Provisional; Region: PRK10034; cl15264 508765006641 Na+-H+ antiporter family; Region: Na_H_antiport_2; pfam13726 508765006642 Sugar diacid utilization regulator [Transcription / Signal transduction mechanisms]; Region: CdaR; COG3835 508765006643 Putative sugar diacid recognition; Region: Diacid_rec; pfam05651 508765006644 PucR C-terminal helix-turn-helix domain; Region: HTH_30; pfam13556 508765006645 Lumazine-binding domain; Region: Lumazine_bd; pfam12870 508765006646 Probable zinc-binding domain; Region: zf-trcl; pfam13451 508765006647 Glucose inhibited division protein A; Region: GIDA; pfam01134 508765006648 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450 508765006649 tRNA:m(5)U-54 methyltransferase; Region: gid_trmFO; TIGR00137 508765006650 hypothetical protein; Provisional; Region: PRK05802 508765006651 FAD/NAD binding domain (electron transfer subunit) of dihydroorotate dehydrogenase-like proteins. Dihydroorotate dehydrogenases (DHODs) catalyze the only redox reaction in pyrimidine de novo biosynthesis. They catalyze the oxidation of (S)-dihydroorotate...; Region: DHOD_e_trans_like; cd06192 508765006652 FAD binding pocket [chemical binding]; other site 508765006653 FAD binding motif [chemical binding]; other site 508765006654 phosphate binding motif [ion binding]; other site 508765006655 beta-alpha-beta structure motif; other site 508765006656 NAD binding pocket [chemical binding]; other site 508765006657 Iron coordination center [ion binding]; other site 508765006658 hypothetical protein; Validated; Region: PRK02101 508765006659 D-alanyl-D-alanine carboxypeptidase; Region: Peptidase_S11; pfam00768 508765006660 Beta-lactamase enzyme family; Region: Beta-lactamase2; cl17872 508765006661 Protein of unknown function (DUF2953); Region: DUF2953; pfam11167 508765006662 sporulation protein YtfJ; Region: spore_ytfJ; TIGR02874 508765006663 segregation and condensation protein B; Reviewed; Region: scpB; PRK00135 508765006664 segregation and condensation protein A; Reviewed; Region: scpA; PRK00104 508765006665 Beta-lactamase enzyme family; Region: Beta-lactamase2; cl17872 508765006666 D-alanyl-D-alanine carboxypeptidase [Cell envelope biogenesis, outer membrane]; Region: DacC; COG1686 508765006667 Penicillin-binding protein 5, C-terminal domain; Region: PBP5_C; smart00936 508765006668 DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213 508765006669 tyrosine recombinase XerD; Region: recomb_XerD; TIGR02225 508765006670 active site 508765006671 DNA binding site [nucleotide binding] 508765006672 Int/Topo IB signature motif; other site 508765006673 Integral membrane protein DUF95; Region: DUF95; cl00572 508765006674 cytoplasmic alpha-amylase; Reviewed; Region: PRK09441 508765006675 Alpha amylase catalytic domain found in bacterial and fungal Alpha amylases (also called 1,4-alpha-D-glucan-4-glucanohydrolase); Region: AmyAc_bac_fung_AmyA; cd11318 508765006676 active site 508765006677 Na/Ca binding site [ion binding]; other site 508765006678 catalytic site [active] 508765006679 Domain of unknown function (DUF1939); Region: DUF1939; pfam09154 508765006680 FAD/FMN-containing dehydrogenases [Energy production and conversion]; Region: GlcD; COG0277 508765006681 FAD binding domain; Region: FAD_binding_4; pfam01565 508765006682 Berberine and berberine like; Region: BBE; pfam08031 508765006683 Phage portal protein, SPP1 Gp6-like; Region: Phage_prot_Gp6; pfam05133 508765006684 phage portal protein, SPP1 family; Region: portal_SPP1; TIGR01538 508765006685 large terminase protein; Provisional; Region: 17; PHA02533 508765006686 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 508765006687 non-specific DNA binding site [nucleotide binding]; other site 508765006688 salt bridge; other site 508765006689 sequence-specific DNA binding site [nucleotide binding]; other site 508765006690 Site-specific recombinase XerD [DNA replication, recombination, and repair]; Region: XerD; COG4974 508765006691 DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213 508765006692 active site 508765006693 Int/Topo IB signature motif; other site 508765006694 DNA binding site [nucleotide binding] 508765006695 sporulation transcription factor Spo0A; Region: spore_0_A; TIGR02875 508765006696 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 508765006697 active site 508765006698 phosphorylation site [posttranslational modification] 508765006699 intermolecular recognition site; other site 508765006700 dimerization interface [polypeptide binding]; other site 508765006701 Sporulation initiation factor Spo0A C terminal; Region: Spo0A_C; pfam08769 508765006702 PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal)...; Region: PDZ_signaling; cd00992 508765006703 protein binding site [polypeptide binding]; other site 508765006704 SpoIVB peptidase S55; Region: Peptidase_S55; pfam05580 508765006705 ATPase involved in DNA repair [DNA replication, recombination, and repair]; Region: RecN; COG0497 508765006706 ATP-binding cassette domain of RecN; Region: ABC_RecN; cd03241 508765006707 Walker A/P-loop; other site 508765006708 ATP binding site [chemical binding]; other site 508765006709 Q-loop/lid; other site 508765006710 ATP-binding cassette domain of RecN; Region: ABC_RecN; cd03241 508765006711 ABC transporter signature motif; other site 508765006712 Walker B; other site 508765006713 D-loop; other site 508765006714 H-loop/switch region; other site 508765006715 arginine repressor; Provisional; Region: argR; PRK00441 508765006716 Arginine repressor, DNA binding domain; Region: Arg_repressor; pfam01316 508765006717 Arginine repressor, C-terminal domain; Region: Arg_repressor_C; pfam02863 508765006718 ATP-NAD kinase; Region: NAD_kinase; pfam01513 508765006719 NAD kinase [Coenzyme metabolism]; Region: nadF; COG0061 508765006720 Predicted rRNA methylase [Translation, ribosomal structure and biogenesis]; Region: COG1189 508765006721 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 508765006722 RNA binding surface [nucleotide binding]; other site 508765006723 FtsJ-like methyltransferase; Region: FtsJ; pfam01728 508765006724 1-deoxy-D-xylulose-5-phosphate synthase; Provisional; Region: PRK05444 508765006725 Thiamine pyrophosphate (TPP) family, DXS subfamily, TPP-binding module; 1-Deoxy-D-xylulose-5-phosphate synthase (DXS) is a regulatory enzyme of the mevalonate-independent pathway involved in terpenoid biosynthesis. Terpeniods are plant natural products...; Region: TPP_DXS; cd02007 508765006726 TPP-binding site; other site 508765006727 Pyrimidine (PYR) binding domain of 1-deoxy-D-xylulose-5-phosphate synthase (DXS), transketolase (TK), and related proteins; Region: TPP_PYR_DXS_TK_like; cd07033 508765006728 PYR/PP interface [polypeptide binding]; other site 508765006729 dimer interface [polypeptide binding]; other site 508765006730 TPP binding site [chemical binding]; other site 508765006731 Transketolase, C-terminal domain; Region: Transketolase_C; pfam02780 508765006732 Geranylgeranyl pyrophosphate synthase [Coenzyme metabolism]; Region: IspA; COG0142 508765006733 Trans-Isoprenyl Diphosphate Synthases, head-to-tail; Region: Trans_IPPS_HT; cd00685 508765006734 substrate binding pocket [chemical binding]; other site 508765006735 chain length determination region; other site 508765006736 substrate-Mg2+ binding site; other site 508765006737 catalytic residues [active] 508765006738 aspartate-rich region 1; other site 508765006739 active site lid residues [active] 508765006740 aspartate-rich region 2; other site 508765006741 exodeoxyribonuclease VII small subunit; Provisional; Region: PRK00977 508765006742 exodeoxyribonuclease VII large subunit; Reviewed; Region: xseA; PRK00286 508765006743 ExoVII_LU_OBF: A subfamily of OB folds corresponding to the N-terminal OB-fold domain of Escherichia coli exodeoxyribonuclease VII (ExoVII) large subunit. E. coli ExoVII is composed of two non-identical subunits. E. coli ExoVII is a...; Region: ExoVII_LU_OBF; cd04489 508765006744 generic binding surface II; other site 508765006745 generic binding surface I; other site 508765006746 bifunctional 5,10-methylene-tetrahydrofolate dehydrogenase/ 5,10-methylene-tetrahydrofolate cyclohydrolase; Provisional; Region: PRK14172 508765006747 Tetrahydrofolate dehydrogenase/cyclohydrolase, catalytic domain; Region: THF_DHG_CYH; pfam00763 508765006748 NADP binding domain of methylene-tetrahydrofolate dehydrogenase/cyclohydrolase; Region: NAD_bind_m-THF_DH_Cyclohyd; cd01080 508765006749 homodimer interface [polypeptide binding]; other site 508765006750 NADP binding site [chemical binding]; other site 508765006751 substrate binding site [chemical binding]; other site 508765006752 transcription antitermination protein NusB; Reviewed; Region: nusB; PRK00202 508765006753 putative RNA binding site [nucleotide binding]; other site 508765006754 Asp23 family; Region: Asp23; pfam03780 508765006755 SpoIIIAH-like protein; Region: SpoIIIAH; pfam12685 508765006756 stage III sporulation protein AG; Region: spore_III_AG; TIGR02830 508765006757 Stage III sporulation protein AF (Spore_III_AF); Region: Spore_III_AF; pfam09581 508765006758 Stage III sporulation protein AE (spore_III_AE); Region: Spore_III_AE; pfam09546 508765006759 stage III sporulation protein AD; Region: spore_III_AD; TIGR02849 508765006760 stage III sporulation protein AC; Region: spore_III_AC; TIGR02848 508765006761 stage III sporulation protein SpoAB; Provisional; Region: PRK08307 508765006762 stage III sporulation protein AA; Region: spore_III_AA; TIGR02858 508765006763 RecA-like NTPases. This family includes the NTP binding domain of F1 and V1 H+ATPases, DnaB and related helicases as well as bacterial RecA and related eukaryotic and archaeal recombinases. This group also includes bacterial conjugation proteins and...; Region: RecA-like_NTPases; cl17233 508765006764 Walker A motif; other site 508765006765 ATP binding site [chemical binding]; other site 508765006766 elongation factor P; Validated; Region: PRK00529 508765006767 Elongation factor P (EF-P) KOW-like domain; Region: EFP_N; pfam08207 508765006768 S1_EF-P_repeat_1: Translation elongation factor P (EF-P), S1-like RNA-binding domain, repeat 1. EF-P stimulates the peptidyltransferase activity in the prokaryotic 70S ribosome. EF-P enhances the synthesis of certain dipeptides with...; Region: S1_EF-P_repeat_1; cd04470 508765006769 RNA binding site [nucleotide binding]; other site 508765006770 S1_EF-P_repeat_2: Translation elongation factor P (EF-P), S1-like RNA-binding domain, repeat 1. EF-P stimulates the peptidyltransferase activity in the prokaryotic 70S ribosome. EF-P enhances the synthesis of certain dipeptides with...; Region: S1_EF-P_repeat_2; cd05794 508765006771 RNA binding site [nucleotide binding]; other site 508765006772 Type II secretion system (T2SS), protein F; Region: T2SF; pfam00482 508765006773 Type II secretion system (T2SS), protein F; Region: T2SF; pfam00482 508765006774 Type II/IV secretion system protein; Region: T2SE; pfam00437 508765006775 RecA-like NTPases. This family includes the NTP binding domain of F1 and V1 H+ATPases, DnaB and related helicases as well as bacterial RecA and related eukaryotic and archaeal recombinases. This group also includes bacterial conjugation proteins and...; Region: RecA-like_NTPases; cl17233 508765006776 Walker A motif; other site 508765006777 ATP binding site [chemical binding]; other site 508765006778 Walker B motif; other site 508765006779 diaminopimelate epimerase; Provisional; Region: dapF; PRK00450 508765006780 Diaminopimelate epimerase; Region: DAP_epimerase; pfam01678 508765006781 Diaminopimelate epimerase; Region: DAP_epimerase; pfam01678 508765006782 Fibronectin-binding protein A N-terminus (FbpA); Region: FbpA; pfam05833 508765006783 Domain of unknown function (DUF814); Region: DUF814; pfam05670 508765006784 Predicted N6-adenine-specific DNA methylase [DNA replication, recombination, and repair]; Region: COG0116 508765006785 THUMP domain associated with S-adenosylmethionine-dependent methyltransferases; Region: THUMP_AdoMetMT; cd11715 508765006786 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl17173 508765006787 Pyrimidine operon attenuation protein/uracil phosphoribosyltransferase [Nucleotide transport and metabolism]; Region: PyrR; COG2065 508765006788 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 508765006789 active site 508765006790 Pseudouridylate synthases, 23S RNA-specific [Translation, ribosomal structure and biogenesis]; Region: RluA; COG0564 508765006791 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 508765006792 RNA binding surface [nucleotide binding]; other site 508765006793 Pseudouridine synthase, RsuA/RluD family; Region: PseudoU_synth_RluCD_like; cd02869 508765006794 active site 508765006795 DivIVA protein; Region: DivIVA; pfam05103 508765006796 DivIVA domain; Region: DivI1A_domain; TIGR03544 508765006797 Uncharacterized conserved protein, contains S4-like domain [Function unknown]; Region: COG2302 508765006798 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 508765006799 RNA binding surface [nucleotide binding]; other site 508765006800 YGGT family; Region: YGGT; pfam02325 508765006801 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG1799 508765006802 Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzymes, YBL036c-like proteins; Region: PLPDE_III_YBL036c_like; cd00635 508765006803 pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site 508765006804 catalytic residue [active] 508765006805 Bacterial protein of unknown function (DUF881); Region: DUF881; pfam05949 508765006806 Protein of unknown function (DUF1290); Region: DUF1290; pfam06947 508765006807 Bacterial protein of unknown function (DUF881); Region: DUF881; pfam05949 508765006808 Cell division septal protein [Cell envelope biogenesis, outer membrane]; Region: FtsQ; COG1589 508765006809 POTRA domain, FtsQ-type; Region: POTRA_1; pfam08478 508765006810 Cell cycle protein; Region: FTSW_RODA_SPOVE; cl00511 508765006811 phospho-N-acetylmuramoyl-pentapeptide-transferase; Provisional; Region: mraY; PRK00108 508765006812 Phospho-N-acetylmuramoyl-pentapeptide-transferase (mraY) is an enzyme responsible for the formation of the first lipid intermediate in the synthesis of bacterial cell wall peptidoglycan. It catalyzes the formation of...; Region: GT_MraY; cd06852 508765006813 Mg++ binding site [ion binding]; other site 508765006814 putative catalytic motif [active] 508765006815 putative substrate binding site [chemical binding]; other site 508765006816 UDP-N-acetylmuramyl pentapeptide synthase [Cell envelope biogenesis, outer membrane]; Region: MurF; COG0770 508765006817 Mur ligase family, catalytic domain; Region: Mur_ligase; pfam01225 508765006818 Mur ligase middle domain; Region: Mur_ligase_M; pfam08245 508765006819 Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875 508765006820 UDP-N-acetylmuramoylalanyl-D-glutamate--2, 6-diaminopimelate ligase; Provisional; Region: murE; PRK00139 508765006821 Mur ligase family, catalytic domain; Region: Mur_ligase; pfam01225 508765006822 Mur ligase middle domain; Region: Mur_ligase_M; pfam08245 508765006823 Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875 508765006824 stage V sporulation protein D; Region: spoVD_pbp; TIGR02214 508765006825 Penicillin-binding Protein dimerisation domain; Region: PBP_dimer; pfam03717 508765006826 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; pfam00905 508765006827 PASTA domain of PBP2x-like proteins, first repeat. Penicillin-binding proteins (PBPs) are the major targets for beta-lactam antibiotics, like penicillins and cephalosporins. Beta-lactam antibiotics specifically inhibit transpeptidase activity by...; Region: PASTA_Pbp2x-like_1; cd06576 508765006828 PASTA domain of PBP2x-like proteins, second repeat. Penicillin-binding proteins (PBPs) are the major targets for beta-lactam antibiotics, like penicillins and cephalosporins. Beta-lactam antibiotics specifically inhibit transpeptidase activity by...; Region: PASTA_Pbp2x-like_2; cd06575 508765006829 MraW methylase family; Region: Methyltransf_5; pfam01795 508765006830 16S rRNA m(4)C1402 methyltranserfase; Provisional; Region: PRK00050 508765006831 cell division protein MraZ; Reviewed; Region: PRK00326 508765006832 MraZ protein; Region: MraZ; pfam02381 508765006833 MraZ protein; Region: MraZ; pfam02381 508765006834 Integral membrane protein TerC family; Region: TerC; cl10468 508765006835 GTP-binding protein YchF; Reviewed; Region: PRK09601 508765006836 YchF GTPase; Region: YchF; cd01900 508765006837 G1 box; other site 508765006838 GTP/Mg2+ binding site [chemical binding]; other site 508765006839 Switch I region; other site 508765006840 G2 box; other site 508765006841 Switch II region; other site 508765006842 G3 box; other site 508765006843 G4 box; other site 508765006844 G5 box; other site 508765006845 TGS_YchF_C: This subfamily represents TGS domain-containing YchF GTP-binding protein, a universally conserved GTPase whose function is unknown. The N-terminal domain of the YchF protein belongs to the Obg-like family of GTPases, and some members of the...; Region: TGS_YchF_C; cd04867 508765006846 Catalytic NodB homology domain of Bacillus subtilis polysaccharide deacetylase PdaA, and its bacterial homologs; Region: CE4_BsPdaA_like; cd10948 508765006847 delta-lactam-biosynthetic de-N-acetylase; Region: spore_pdaA; TIGR02884 508765006848 NodB motif; other site 508765006849 active site 508765006850 catalytic site [active] 508765006851 Cd binding site [ion binding]; other site 508765006852 Formiminotransferase-cyclodeaminase; Region: FTCD_C; pfam04961 508765006853 Lipid A core - O-antigen ligase and related enzymes [Cell envelope biogenesis, outer membrane]; Region: RfaL; COG3307 508765006854 O-Antigen ligase; Region: Wzy_C; pfam04932 508765006855 This family is most closely related to the GT1 family of glycosyltransferases. wlbH in Bordetella parapertussis has been shown to be required for the biosynthesis of a trisaccharide that, when attached to the B. pertussis lipopolysaccharide (LPS) core; Region: GT1_wlbH_like; cd03798 508765006856 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 508765006857 Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013 508765006858 Uncharacterized membrane protein, putative virulence factor [General function prediction only]; Region: MviN; COG0728 508765006859 MurJ/MviN, a subfamily of the multidrug and toxic compound extrusion (MATE)-like proteins; Region: MATE_MurJ_like; cd13123 508765006860 Teichoic acid biosynthesis proteins [Cell envelope biogenesis, outer membrane]; Region: WecG; COG1922 508765006861 The glycosyltransferase WecG/TagA superfamily contains Escherichia coli WecG, Bacillus subtilis TagA and related proteins. E. coli WecG is believed to be a UDP-N-acetyl-D-mannosaminuronic acid transferase, and is involved in enterobacterial common...; Region: Glyco_transf_WecG_TagA; cd06533 508765006862 Tetratricopeptide repeat; Region: TPR_12; pfam13424 508765006863 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 508765006864 binding surface 508765006865 TPR motif; other site 508765006866 Phosphomannomutase [Carbohydrate transport and metabolism]; Region: {ManB}; COG1109 508765006867 This CD includes PGM2 (phosphoglucomutase 2) and PGM2L1 (phosphoglucomutase 2-like 1). The mammalian PGM2 is thought to be a phosphopentomutase that catalyzes the conversion of the nucleoside breakdown products, ribose-1-phosphate and...; Region: PGM2; cd05799 508765006868 active site 508765006869 substrate binding site [chemical binding]; other site 508765006870 metal binding site [ion binding]; metal-binding site 508765006871 Protein of unknown function (DUF523); Region: DUF523; pfam04463 508765006872 recombination and DNA strand exchange inhibitor protein; Reviewed; Region: PRK00409 508765006873 MutS domain III; Region: MutS_III; pfam05192 508765006874 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 508765006875 Walker A/P-loop; other site 508765006876 ATP binding site [chemical binding]; other site 508765006877 Q-loop/lid; other site 508765006878 ABC transporter signature motif; other site 508765006879 Walker B; other site 508765006880 D-loop; other site 508765006881 H-loop/switch region; other site 508765006882 ATP synthase B/B' CF(0); Region: ATP-synt_B; cl17192 508765006883 Smr domain; Region: Smr; pfam01713 508765006884 Collagenase and related proteases [Posttranslational modification, protein turnover, chaperones]; Region: COG0826 508765006885 Peptidase family U32; Region: Peptidase_U32; pfam01136 508765006886 Collagenase; Region: DUF3656; pfam12392 508765006887 Peptidase family U32; Region: Peptidase_U32; cl03113 508765006888 Cell division protein ZapA; Region: ZapA; pfam05164 508765006889 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 508765006890 Major Facilitator Superfamily; Region: MFS_1; pfam07690 508765006891 putative substrate translocation pore; other site 508765006892 Predicted hydrolase (metallo-beta-lactamase superfamily) [General function prediction only]; Region: ComEC; COG2333 508765006893 Metallo-beta-lactamase superfamily; Region: Lactamase_B; pfam00753 508765006894 Mechanosensitive ion channel; Region: MS_channel; pfam00924 508765006895 LD-Carboxypeptidase, a serine protease, includes microcin C7 self immunity protein; Region: Peptidase_S66; cd07025 508765006896 dimer interface [polypeptide binding]; other site 508765006897 catalytic triad [active] 508765006898 PF-ChiA is an uncharacterized chitinase found in the hyperthermophilic archaeon Pyrococcus furiosus with a glycosyl hydrolase family 18 (GH18) catalytic domain as well as a cellulose-binding domain. Members of this domain family are found not only in...; Region: GH18_PF-ChiA-like; cd06543 508765006899 active site 508765006900 Bacterial Ig-like domain (group 3); Region: Big_3; pfam07523 508765006901 Chitin-binding domain of chitinase C; Region: ChiC_BD; cd12215 508765006902 aromatic chitin/cellulose binding site residues [chemical binding]; other site 508765006903 Cellulose-binding domain, chitinase and related proteins; Region: CBD_like; cd12204 508765006904 aromatic chitin/cellulose binding site residues [chemical binding]; other site 508765006905 ligand binding site [chemical binding]; other site 508765006906 phenylalanyl-tRNA synthetase subunit beta; Reviewed; Region: pheT; PRK00629 508765006907 tRNA-binding-domain-containing prokaryotic phenylalanly tRNA synthetase (PheRS) beta chain. PheRS aminoacylate phenylalanine transfer RNAs (tRNAphe). PheRSs belong structurally to class II aminoacyl tRNA synthetases (aaRSs) but, as they aminoacylate...; Region: tRNA_bind_bactPheRS; cd02796 508765006908 putative tRNA-binding site [nucleotide binding]; other site 508765006909 B3/4 domain; Region: B3_4; pfam03483 508765006910 tRNA synthetase B5 domain; Region: B5; smart00874 508765006911 Phenylalanyl-tRNA synthetase (PheRS) beta chain core domain. PheRS belongs to class II aminoacyl-tRNA synthetases (aaRS) based upon its structure. While class II aaRSs generally aminoacylate the 3'-OH ribose of the appropriate tRNA, PheRS is an...; Region: PheRS_beta_core; cd00769 508765006912 dimer interface [polypeptide binding]; other site 508765006913 motif 1; other site 508765006914 motif 3; other site 508765006915 motif 2; other site 508765006916 Ferredoxin-fold anticodon binding domain; Region: FDX-ACB; pfam03147 508765006917 phenylalanyl-tRNA synthetase subunit alpha; Validated; Region: pheS; PRK00488 508765006918 Aminoacyl tRNA synthetase class II, N-terminal domain; Region: Phe_tRNA-synt_N; pfam02912 508765006919 Phenylalanyl-tRNA synthetase (PheRS) alpha chain catalytic core domain. PheRS belongs to class II aminoacyl-tRNA synthetases (aaRS) based upon its structure and the presence of three characteristic sequence motifs. This domain is primarily responsible...; Region: PheRS_alpha_core; cd00496 508765006920 dimer interface [polypeptide binding]; other site 508765006921 motif 1; other site 508765006922 active site 508765006923 motif 2; other site 508765006924 motif 3; other site 508765006925 T-box leader 508765006926 rRNA methylases [Translation, ribosomal structure and biogenesis]; Region: SpoU; COG0566 508765006927 RNA 2'-O ribose methyltransferase substrate binding; Region: SpoU_sub_bind; smart00967 508765006928 SpoU rRNA Methylase family; Region: SpoU_methylase; pfam00588 508765006929 K+ transport systems, NAD-binding component [Inorganic ion transport and metabolism]; Region: TrkA; COG0569 508765006930 TrkA-N domain; Region: TrkA_N; pfam02254 508765006931 TrkA-C domain; Region: TrkA_C; pfam02080 508765006932 Trk-type K+ transport systems, membrane components [Inorganic ion transport and metabolism]; Region: TrkG; COG0168 508765006933 potassium uptake protein, TrkH family; Region: 2a38; TIGR00933 508765006934 Ribosomal protein L20; Region: Ribosomal_L20; cd07026 508765006935 23S rRNA binding site [nucleotide binding]; other site 508765006936 L21 binding site [polypeptide binding]; other site 508765006937 L13 binding site [polypeptide binding]; other site 508765006938 50S ribosomal protein L35; Reviewed; Region: rpmI; PRK00172 508765006939 translation initiation factor IF-3; Reviewed; Region: infC; PRK00028 508765006940 Translation initiation factor IF-3, N-terminal domain; Region: IF3_N; pfam05198 508765006941 Translation initiation factor IF-3, C-terminal domain; Region: IF3_C; pfam00707 508765006942 Ribosomal protein L20 leader 508765006943 YtxC-like family; Region: YtxC; cl08500 508765006944 Hsp33-like chaperonin; Reviewed; Region: hslO; PRK00114 508765006945 Heat shock protein 33 (Hsp33): Cytosolic protein that acts as a molecular chaperone under oxidative conditions. In normal (reducing) cytosolic conditions, four conserved Cys residues are coordinated by a Zn ion. Under oxidative stress (such as heat...; Region: Hsp33; cd00498 508765006946 dimerization interface [polypeptide binding]; other site 508765006947 domain crossover interface; other site 508765006948 redox-dependent activation switch; other site 508765006949 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 508765006950 S-adenosylmethionine binding site [chemical binding]; other site 508765006951 Small, acid-soluble spore proteins, alpha/beta type; Region: SASP; pfam00269 508765006952 aspartate-semialdehyde dehydrogenase; Provisional; Region: PRK14874 508765006953 Semialdehyde dehydrogenase, NAD binding domain; Region: Semialdhyde_dh; smart00859 508765006954 Glyceraldehyde 3-phosphate dehydrogenase, C-terminal domain; Region: Gp_dh_C; pfam02800 508765006955 Dihydrodipicolinate synthase (DHDPS); Region: DHDPS; cd00950 508765006956 dihydrodipicolinate synthase; Region: dapA; TIGR00674 508765006957 dimer interface [polypeptide binding]; other site 508765006958 active site 508765006959 catalytic residue [active] 508765006960 dihydrodipicolinate reductase; Provisional; Region: PRK00048 508765006961 Dihydrodipicolinate reductase, N-terminus; Region: DapB_N; pfam01113 508765006962 Dihydrodipicolinate reductase, C-terminus; Region: DapB_C; pfam05173 508765006963 ABC-type oligopeptide transport system, periplasmic component [Amino acid transport and metabolism]; Region: OppA; COG4166 508765006964 The substrate-binding component of an ABC-type oligopetide import system contains the type 2 periplasmic binding fold; Region: PBP2_OppA; cd08504 508765006965 peptide binding site [polypeptide binding]; other site 508765006966 oligopeptide ABC transporter ATP-binding protein OppF; Provisional; Region: PRK15079 508765006967 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 508765006968 Walker A/P-loop; other site 508765006969 ATP binding site [chemical binding]; other site 508765006970 Q-loop/lid; other site 508765006971 ABC transporter signature motif; other site 508765006972 Walker B; other site 508765006973 D-loop; other site 508765006974 H-loop/switch region; other site 508765006975 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097 508765006976 ABC-type dipeptide/oligopeptide/nickel transport system, ATPase component [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppD; COG0444 508765006977 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 508765006978 Walker A/P-loop; other site 508765006979 ATP binding site [chemical binding]; other site 508765006980 Q-loop/lid; other site 508765006981 ABC transporter signature motif; other site 508765006982 Walker B; other site 508765006983 D-loop; other site 508765006984 H-loop/switch region; other site 508765006985 oligopeptide/dipeptide ABC transporter, ATP-binding protein, C-terminal domain; Region: oligo_HPY; TIGR01727 508765006986 N-terminal TM domain of oligopeptide transport permease C; Region: OppC_N; pfam12911 508765006987 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppC; COG1173 508765006988 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 508765006989 dimer interface [polypeptide binding]; other site 508765006990 conserved gate region; other site 508765006991 putative PBP binding loops; other site 508765006992 ABC-ATPase subunit interface; other site 508765006993 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppB; COG0601 508765006994 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 508765006995 dimer interface [polypeptide binding]; other site 508765006996 conserved gate region; other site 508765006997 putative PBP binding loops; other site 508765006998 ABC-ATPase subunit interface; other site 508765006999 ABC-type oligopeptide transport system, periplasmic component [Amino acid transport and metabolism]; Region: OppA; COG4166 508765007000 The substrate-binding component of an ABC-type oligopetide import system contains the type 2 periplasmic binding fold; Region: PBP2_OppA; cd08504 508765007001 peptide binding site [polypeptide binding]; other site 508765007002 aminotransferase A; Validated; Region: PRK07683 508765007003 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 508765007004 pyridoxal 5'-phosphate binding site [chemical binding]; other site 508765007005 homodimer interface [polypeptide binding]; other site 508765007006 catalytic residue [active] 508765007007 Tetrahydrodipicolinate succinyltransferase N-terminal; Region: DapH_N; pfam08503 508765007008 2,3,4,5-tetrahydropyridine-2,6-dicarboxylate N-acetyltransferase; Region: DapD_Ac; TIGR03532 508765007009 2,3,4,5-tetrahydropyridine-2,6-dicarboxylate (THDP) N-succinyltransferase (also called THP succinyltransferase): THDP N-succinyltransferase catalyzes the conversion of tetrahydrodipicolinate and succinyl-CoA to N-succinyltetrahydrodipicolinate and CoA; Region: LbH_THP_succinylT; cd03350 508765007010 active site 508765007011 trimer interface [polypeptide binding]; other site 508765007012 substrate binding site [chemical binding]; other site 508765007013 CoA binding site [chemical binding]; other site 508765007014 Left-handed parallel beta-Helix (LbetaH or LbH) domain: The alignment contains 5 turns, each containing three imperfect tandem repeats of a hexapeptide repeat motif (X-[STAV]-X-[LIV]-[GAED]-X). Proteins containing hexapeptide repeats are often enzymes...; Region: LbetaH; cl00160 508765007015 putative CoA binding site [chemical binding]; other site 508765007016 putative trimer interface [polypeptide binding]; other site 508765007017 single-stranded DNA-binding protein; Provisional; Region: PRK05813 508765007018 SSB_OBF: A subfamily of OB folds similar to the OB fold of ssDNA-binding protein (SSB). SSBs bind with high affinity to ssDNA. They bind to and protect ssDNA intermediates during DNA metabolic pathways. All bacterial and eukaryotic SSBs studied to date...; Region: SSB_OBF; cd04496 508765007019 dimer interface [polypeptide binding]; other site 508765007020 ssDNA binding site [nucleotide binding]; other site 508765007021 tetramer (dimer of dimers) interface [polypeptide binding]; other site 508765007022 Catalytic NodB homology domain of rhizobial NodB-like proteins; Region: CE4_NodB_like_6s_7s; cd10917 508765007023 NodB motif; other site 508765007024 active site 508765007025 catalytic site [active] 508765007026 metal binding site [ion binding]; metal-binding site 508765007027 Domain of unknown function (DUF4364); Region: DUF4364; pfam14277 508765007028 Predicted transcriptional regulator [Transcription]; Region: COG3432 508765007029 Uncharacterized conserved protein [Function unknown]; Region: COG3391 508765007030 TSCPD domain; Region: TSCPD; cl14834 508765007031 The HIRAN protein (HIP116, Rad5p N-terminal) is found in the N-terminal regions of the SWI2/SNF2 proteins typified by HIP116 and Rad5p; Region: HIRAN; smart00910 508765007032 Folylpolyglutamate synthase [Coenzyme metabolism]; Region: FolC; COG0285 508765007033 Mur ligase middle domain; Region: Mur_ligase_M; pfam08245 508765007034 Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875 508765007035 hypothetical protein; Provisional; Region: PRK01119 508765007036 valyl-tRNA synthetase; Reviewed; Region: valS; PRK05729 508765007037 nucleotidyl transferase superfamily; Region: nt_trans; cl00015 508765007038 active site 508765007039 HIGH motif; other site 508765007040 nucleotide binding site [chemical binding]; other site 508765007041 Leucyl-tRNA synthetase, Domain 2; Region: tRNA-synt_1_2; pfam13603 508765007042 catalytic core domain of valyl-tRNA synthetases; Region: ValRS_core; cd00817 508765007043 active site 508765007044 KMSKS motif; other site 508765007045 Anticodon-binding domain of valyl tRNA synthetases; Region: Anticodon_Ia_Val; cd07962 508765007046 tRNA binding surface [nucleotide binding]; other site 508765007047 anticodon binding site; other site 508765007048 Valyl tRNA synthetase tRNA binding arm; Region: Val_tRNA-synt_C; pfam10458 508765007049 T-box leader 508765007050 aspartyl-tRNA synthetase; Provisional; Region: aspC; PRK05159 508765007051 Replication protein A, class 2b aminoacyl-tRNA synthetases, and related proteins with oligonucleotide/oligosaccharide (OB) fold; Region: RPA_2b-aaRSs_OBF_like; cl09930 508765007052 Dimer interface [polypeptide binding]; other site 508765007053 anticodon binding site; other site 508765007054 Asx tRNA synthetase (AspRS/AsnRS) class II core domain. Assignment to class II aminoacyl-tRNA synthetases (aaRS) based upon its structure and the presence of three characteristic sequence motifs in the core domain. This family includes AsnRS as well as...; Region: AsxRS_core; cd00776 508765007055 homodimer interface [polypeptide binding]; other site 508765007056 motif 1; other site 508765007057 motif 2; other site 508765007058 active site 508765007059 motif 3; other site 508765007060 T-box leader 508765007061 Microcin C7 self-immunity protein determines resistance to exogenous microcin C7; Region: Peptidase_S66_mccF_like; cd07062 508765007062 putative dimer interface [polypeptide binding]; other site 508765007063 catalytic triad [active] 508765007064 undecaprenyl phosphate 4-deoxy-4-formamido-L-arabinose transferase; Provisional; Region: PRK10714 508765007065 Bacterial DPM1_like enzymes are related to eukaryotic DPM1; Region: DPM1_like_bac; cd04187 508765007066 Ligand binding site; other site 508765007067 Putative Catalytic site; other site 508765007068 DXD motif; other site 508765007069 Predicted membrane protein [Function unknown]; Region: COG2246 508765007070 GtrA-like protein; Region: GtrA; pfam04138 508765007071 Uncharacterized oxidoreductases, Fe-dependent alcohol dehydrogenase family [Energy production and conversion]; Region: COG1979 508765007072 Butanol dehydrogenase catalyzes the conversion of butyraldehyde to butanol with the cofactor NAD(P)H being oxidized in the process; Region: BDH; cd08187 508765007073 dimer interface [polypeptide binding]; other site 508765007074 active site 508765007075 metal binding site [ion binding]; metal-binding site 508765007076 16S rRNA uridine-516 pseudouridylate synthase and related pseudouridylate synthases [Translation, ribosomal structure and biogenesis]; Region: RsuA; COG1187 508765007077 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 508765007078 RNA binding surface [nucleotide binding]; other site 508765007079 Pseudouridine synthase, Escherichia coli RluF like; Region: PseudoU_synth_RluF; cd02554 508765007080 probable active site [active] 508765007081 Y_Y_Y domain; Region: Y_Y_Y; pfam07495 508765007082 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 508765007083 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 508765007084 dimer interface [polypeptide binding]; other site 508765007085 phosphorylation site [posttranslational modification] 508765007086 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 508765007087 ATP binding site [chemical binding]; other site 508765007088 Mg2+ binding site [ion binding]; other site 508765007089 G-X-G motif; other site 508765007090 putative UV damage endonuclease; Provisional; Region: uvsE; PRK02308 508765007091 conserved repeat domain; Region: B_ant_repeat; TIGR01451 508765007092 Domain of unknown function (DUF3794); Region: DUF3794; pfam12673 508765007093 Domain of unknown function DUF11; Region: DUF11; cl17728 508765007094 Domain of unknown function DUF11; Region: DUF11; cl17728 508765007095 Domain of unknown function DUF11; Region: DUF11; cl17728 508765007096 conserved repeat domain; Region: B_ant_repeat; TIGR01451 508765007097 conserved repeat domain; Region: B_ant_repeat; TIGR01451 508765007098 conserved repeat domain; Region: B_ant_repeat; TIGR01451 508765007099 Domain of unknown function DUF11; Region: DUF11; cl17728 508765007100 Domain of unknown function DUF11; Region: DUF11; cl17728 508765007101 conserved repeat domain; Region: B_ant_repeat; TIGR01451 508765007102 conserved repeat domain; Region: B_ant_repeat; TIGR01451 508765007103 conserved repeat domain; Region: B_ant_repeat; TIGR01451 508765007104 conserved repeat domain; Region: B_ant_repeat; TIGR01451 508765007105 Domain of unknown function DUF11; Region: DUF11; cl17728 508765007106 conserved repeat domain; Region: B_ant_repeat; TIGR01451 508765007107 conserved repeat domain; Region: B_ant_repeat; TIGR01451 508765007108 conserved repeat domain; Region: B_ant_repeat; TIGR01451 508765007109 fimbrial isopeptide formation D2 domain; Region: RrgB_K2N_iso_D2; TIGR04226 508765007110 Subfamily of the multidrug and toxic compound extrusion (MATE)-like proteins similar to Thermotoga marina NorM; Region: MATE_NorM_like; cd13137 508765007111 MATE family multidrug exporter; Provisional; Region: PRK10189 508765007112 Helix-turn-helix domain; Region: HTH_17; cl17695 508765007113 Periplasmic glucose/galactose-binding protein (GGBP) involved in chemotaxis towards, and active transport of, glucose and galactose in various bacterial species; Region: PBP1_GGBP; cd01539 508765007114 Periplasmic binding protein domain; Region: Peripla_BP_4; pfam13407 508765007115 ligand binding site [chemical binding]; other site 508765007116 calcium binding site [ion binding]; other site 508765007117 BadF/BadG/BcrA/BcrD ATPase family; Region: BcrAD_BadFG; cl17271 508765007118 Activator of 2-hydroxyglutaryl-CoA dehydratase (HSP70-class ATPase domain) [Lipid metabolism]; Region: COG1924 508765007119 BadF/BadG/BcrA/BcrD ATPase family; Region: BcrAD_BadFG; cl17271 508765007120 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3580 508765007121 2-hydroxyglutaryl-CoA dehydratase, D-component; Region: HGD-D; pfam06050 508765007122 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3581 508765007123 Tetratricopeptide repeat; Region: TPR_12; pfam13424 508765007124 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 508765007125 binding surface 508765007126 TPR motif; other site 508765007127 TPR repeat; Region: TPR_11; pfam13414 508765007128 Transglutaminase-like enzymes, putative cysteine proteases [Amino acid transport and metabolism]; Region: COG1305 508765007129 Transglutaminase-like superfamily; Region: Transglut_core; pfam01841 508765007130 RecX family; Region: RecX; cl00936 508765007131 Predicted Zn-dependent peptidases [General function prediction only]; Region: PqqL; COG0612 508765007132 Insulinase (Peptidase family M16); Region: Peptidase_M16; pfam00675 508765007133 Peptidase M16 inactive domain; Region: Peptidase_M16_C; pfam05193 508765007134 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 508765007135 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 508765007136 active site 508765007137 phosphorylation site [posttranslational modification] 508765007138 intermolecular recognition site; other site 508765007139 dimerization interface [polypeptide binding]; other site 508765007140 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 508765007141 DNA binding site [nucleotide binding] 508765007142 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 508765007143 dimerization interface [polypeptide binding]; other site 508765007144 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 508765007145 dimer interface [polypeptide binding]; other site 508765007146 phosphorylation site [posttranslational modification] 508765007147 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 508765007148 ATP binding site [chemical binding]; other site 508765007149 Mg2+ binding site [ion binding]; other site 508765007150 G-X-G motif; other site 508765007151 Firmicute fructose-1,6-bisphosphatase; Region: FBPase_2; pfam06874 508765007152 Thioredoxin reductase [Posttranslational modification, protein turnover, chaperones]; Region: TrxB; COG0492 508765007153 Anaerobic glycerol-3-phosphate dehydrogenase [Amino acid transport and metabolism]; Region: GlpB; cl17730 508765007154 TRX family; composed of two groups: Group I, which includes proteins that exclusively encode a TRX domain; and Group II, which are composed of fusion proteins of TRX and additional domains. Group I TRX is a small ancient protein that alter the redox...; Region: TRX_family; cd02947 508765007155 catalytic residues [active] 508765007156 ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132 508765007157 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 508765007158 ATP-binding cassette domain of the bacterial lipid flippase and related proteins, subfamily C; Region: ABCC_MsbA; cd03251 508765007159 Walker A/P-loop; other site 508765007160 ATP binding site [chemical binding]; other site 508765007161 Q-loop/lid; other site 508765007162 ABC transporter signature motif; other site 508765007163 Walker B; other site 508765007164 D-loop; other site 508765007165 H-loop/switch region; other site 508765007166 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 508765007167 putative bacteriocin export ABC transporter, lactococcin 972 group; Region: L_ocin_972_ABC; TIGR03608 508765007168 Walker A/P-loop; other site 508765007169 ATP binding site [chemical binding]; other site 508765007170 Q-loop/lid; other site 508765007171 ABC transporter signature motif; other site 508765007172 Walker B; other site 508765007173 D-loop; other site 508765007174 H-loop/switch region; other site 508765007175 ABC-type nitrate/sulfonate/bicarbonate transport system, permease component [Inorganic ion transport and metabolism]; Region: TauC; COG0600 508765007176 ABC-type nitrate/sulfonate/bicarbonate transport systems, periplasmic components [Inorganic ion transport and metabolism]; Region: TauA; COG0715 508765007177 Protein of unknown function (DUF327); Region: DUF327; pfam03885 508765007178 Glutamine amidotransferases class-II (GATase) asparagine synthase_B type. Asparagine synthetase B catalyses the ATP-dependent conversion of aspartate to asparagine. This enzyme is a homodimer, with each monomer composed of a glutaminase domain and a...; Region: AsnB; cd00712 508765007179 active site 508765007180 asparagine synthase (glutamine-hydrolyzing); Region: asn_synth_AEB; TIGR01536 508765007181 dimer interface [polypeptide binding]; other site 508765007182 The C-terminal domain of Asparagine Synthase B. This domain is always found associated n-terminal amidotransferase domain. Family members that contain this domain catalyse the conversion of aspartate to asparagine. Asparagine synthetase B catalyzes the...; Region: Asn_Synthase_B_C; cd01991 508765007183 Ligand Binding Site [chemical binding]; other site 508765007184 Molecular Tunnel; other site 508765007185 Bacillus/Clostridium GerA spore germination protein; Region: GerA; pfam03323 508765007186 Predicted RNA-bindining protein (contains S1 and HTH domains) [General function prediction only]; Region: COG2996 508765007187 S1 domain; Region: S1_2; pfam13509 508765007188 S1 domain; Region: S1_2; pfam13509 508765007189 Carbonic anhydrases/acetyltransferases, isoleucine patch superfamily [General function prediction only]; Region: PaaY; COG0663 508765007190 Gamma carbonic anhydrase-like: This family is composed of gamma carbonic anhydrase (CA), Ferripyochelin Binding Protein (FBP), E. coli paaY protein, and similar proteins. CAs are zinc-containing enzymes that catalyze the reversible hydration of carbon...; Region: LbH_gamma_CA_like; cd04645 508765007191 trimer interface [polypeptide binding]; other site 508765007192 putative metal binding site [ion binding]; other site 508765007193 Polymerase and Histidinol Phosphatase domain; Region: PHP; cl17102 508765007194 active site 508765007195 Winged helix-turn-helix DNA-binding; Region: HTH_24; pfam13412 508765007196 AsnC family; Region: AsnC_trans_reg; pfam01037 508765007197 Uncharacterized conserved protein [Function unknown]; Region: COG2155 508765007198 Predicted membrane protein [Function unknown]; Region: COG4905 508765007199 Protein of unknown function (DUF1113); Region: DUF1113; pfam06541 508765007200 Phosphoenolpyruvate carboxykinase (PEPCK), a critical gluconeogenic enzyme, catalyzes the first committed step in the diversion of tricarboxylic acid cycle intermediates toward gluconeogenesis. It catalyzes the reversible decarboxylation and...; Region: PEPCK_HprK; cl00270 508765007201 active site 508765007202 metal-binding site [ion binding] 508765007203 nucleotide-binding site [chemical binding]; other site 508765007204 Predicted hydrolase (metallo-beta-lactamase superfamily) [General function prediction only]; Region: ComEC; COG2333 508765007205 Metallo-beta-lactamase superfamily; Region: Lactamase_B; pfam00753 508765007206 glutamyl-tRNA synthetase; Reviewed; Region: gltX; PRK01406 508765007207 catalytic core domain of discriminating glutamyl-tRNA synthetase; Region: GluRS_core; cd00808 508765007208 active site 508765007209 HIGH motif; other site 508765007210 catalytic core domain of discriminating glutamyl-tRNA synthetase; Region: GluRS_core; cd00808 508765007211 active site 508765007212 KMSKS motif; other site 508765007213 RNase_H superfamily; Region: RNase_H_2; pfam13482 508765007214 Phosphoserine phosphatase [Amino acid transport and metabolism]; Region: SerB; COG0560 508765007215 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 508765007216 motif II; other site 508765007217 Fe2+ transport system protein A [Inorganic ion transport and metabolism]; Region: FeoA; COG1918 508765007218 Fe2+ transport system protein B [Inorganic ion transport and metabolism]; Region: FeoB; COG0370 508765007219 Ferrous iron transport protein B (FeoB) family; Region: FeoB; cd01879 508765007220 G1 box; other site 508765007221 GTP/Mg2+ binding site [chemical binding]; other site 508765007222 Switch I region; other site 508765007223 G2 box; other site 508765007224 G3 box; other site 508765007225 Switch II region; other site 508765007226 G4 box; other site 508765007227 G5 box; other site 508765007228 Nucleoside recognition; Region: Gate; pfam07670 508765007229 Ferrous iron transport protein B C terminus; Region: FeoB_C; pfam07664 508765007230 Nucleoside recognition; Region: Gate; pfam07670 508765007231 Predicted permease, member of the PurR regulon [General function prediction only]; Region: yhhT; COG0628 508765007232 Domain of unknown function DUF20; Region: UPF0118; pfam01594 508765007233 arginyl-tRNA synthetase; Reviewed; Region: PRK12451 508765007234 Arginyl tRNA synthetase N terminal dom; Region: Arg_tRNA_synt_N; smart01016 508765007235 catalytic core domain of arginyl-tRNA synthetases; Region: ArgRS_core; cd00671 508765007236 active site 508765007237 HIGH motif; other site 508765007238 KMSK motif region; other site 508765007239 Anticodon-binding domain of arginyl tRNA synthetases; Region: Anticodon_Ia_Arg; cd07956 508765007240 tRNA binding surface [nucleotide binding]; other site 508765007241 anticodon binding site; other site 508765007242 T-box leader 508765007243 Exopolyphosphatase [Nucleotide transport and metabolism / Inorganic ion transport and metabolism]; Region: GppA; COG0248 508765007244 Ppx/GppA phosphatase family; Region: Ppx-GppA; pfam02541 508765007245 Uncharacterized homologs of Site-2 protease (S2P), zinc metalloproteases (MEROPS family M50) which cleave transmembrane domains of substrate proteins, regulating intramembrane proteolysis (RIP) of diverse signal transduction mechanisms. Members of the...; Region: S2P-M50_like_1; cd06158 508765007246 Peptidase family M50; Region: Peptidase_M50; pfam02163 508765007247 active site 508765007248 putative substrate binding region [chemical binding]; other site 508765007249 Exopolysaccharide biosynthesis protein related to N-acetylglucosamine-1-phosphodiester alpha-N-acetylglucosaminidase [Carbohydrate transport and metabolism]; Region: EpsL; COG4632 508765007250 Biotin operon repressor [Transcription]; Region: BirA; COG1654 508765007251 Biotin/lipoate A/B protein ligase family; Region: BPL_LplA_LipB; cl14057 508765007252 Biotin-(acetyl-CoA carboxylase) ligase [Coenzyme metabolism]; Region: BirA; COG0340 508765007253 Biotin protein ligase C terminal domain; Region: BPL_C; pfam02237 508765007254 Asparagine synthetase (aspartate-ammonia ligase) (AsnA) catalyses the conversion of L-aspartate to L-asparagine in the presence of ATP and ammonia. AsnA is a homodimeric enzyme which is structurally similiar to the catalytic core domain of class II...; Region: AsnA; cd00645 508765007255 dimer interface [polypeptide binding]; other site 508765007256 active site 508765007257 L-lactate dehydrogenase; Reviewed; Region: ldh; PRK00066 508765007258 A subgroup of L-lactate dehydrogenases; Region: LDH_2; cd05292 508765007259 NAD binding site [chemical binding]; other site 508765007260 dimer interface [polypeptide binding]; other site 508765007261 substrate binding site [chemical binding]; other site 508765007262 tetramer (dimer of dimers) interface [polypeptide binding]; other site 508765007263 DNA polymerase III, epsilon subunit and related 3'-5' exonucleases [DNA replication, recombination, and repair]; Region: DnaQ; COG0847 508765007264 DEDDh 3'-5' exonuclease domain family; Region: DEDDh; cd06127 508765007265 active site 508765007266 catalytic site [active] 508765007267 substrate binding site [chemical binding]; other site 508765007268 Rubredoxin; nonheme iron binding domains containing a [Fe(SCys)4] center. Rubredoxins are small nonheme iron proteins. The iron atom is coordinated by four cysteine residues (Fe(S-Cys)4), but iron can also be replaced by cobalt, nickel or zinc. They are...; Region: rubredoxin; cd00730 508765007269 Rubredoxin; Region: Rubredoxin; pfam00301 508765007270 iron binding site [ion binding]; other site 508765007271 pyruvate formate-lyase 1-activating enzyme; Region: PFLA; TIGR02493 508765007272 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 508765007273 FeS/SAM binding site; other site 508765007274 formate acetyltransferase 1; Region: pyr_form_ly_1; TIGR01255 508765007275 Pyruvate formate lyase 1; Region: PFL1; cd01678 508765007276 coenzyme A binding site [chemical binding]; other site 508765007277 active site 508765007278 catalytic residues [active] 508765007279 glycine loop; other site 508765007280 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 508765007281 active site 508765007282 dihydroorotate dehydrogenase (subfamily 1) family protein; Region: pyrD_sub1_fam; TIGR01037 508765007283 Dihydroorotate dehydrogenase (DHOD) class 1B FMN-binding domain. DHOD catalyzes the oxidation of (S)-dihydroorotate to orotate. This is the fourth step and the only redox reaction in the de novo biosynthesis of UMP, the precursor of all pyrimidine...; Region: DHOD_1B_like; cd04740 508765007284 heterodimer interface [polypeptide binding]; other site 508765007285 active site 508765007286 FMN binding site [chemical binding]; other site 508765007287 homodimer interface [polypeptide binding]; other site 508765007288 substrate binding site [chemical binding]; other site 508765007289 dihydroorotate dehydrogenase electron transfer subunit; Reviewed; Region: PRK00054 508765007290 FAD/NAD binding domain in the electron transfer subunit of dihydroorotate dehydrogenase. Dihydroorotate dehydrogenases (DHODs) catalyze the only redox reaction in pyrimidine de novo biosynthesis. They catalyze the oxidation of (S)-dihydroorotate to...; Region: DHOD_e_trans; cd06218 508765007291 FAD binding pocket [chemical binding]; other site 508765007292 FAD binding motif [chemical binding]; other site 508765007293 phosphate binding motif [ion binding]; other site 508765007294 beta-alpha-beta structure motif; other site 508765007295 NAD binding pocket [chemical binding]; other site 508765007296 Iron coordination center [ion binding]; other site 508765007297 Orotidine 5'-phosphate decarboxylase (ODCase) is a dimeric enzyme that decarboxylates orotidine 5'-monophosphate (OMP) to form uridine 5'-phosphate (UMP), an essential step in the pyrimidine biosynthetic pathway. In mammals, UMP synthase...; Region: OMP_decarboxylase_like; cd04725 508765007298 active site 508765007299 dimer interface [polypeptide binding]; other site 508765007300 dihydroorotase; Validated; Region: pyrC; PRK09357 508765007301 Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281 508765007302 Dihydroorotase (DHOase), subgroup IIa; DHOases catalyze the reversible interconversion of carbamoyl aspartate to dihydroorotate, a key reaction in pyrimidine biosynthesis. This subgroup also contains proteins that lack the active site, like unc-33, a C; Region: DHOase_IIa; cd01317 508765007303 active site 508765007304 aspartate carbamoyltransferase regulatory subunit; Reviewed; Region: PRK00893 508765007305 Aspartate carbamoyltransferase regulatory chain, allosteric domain; Region: PyrI; pfam01948 508765007306 Aspartate carbamoyltransferase regulatory chain, metal binding domain; Region: PyrI_C; pfam02748 508765007307 aspartate carbamoyltransferase catalytic subunit; Provisional; Region: pyrB; PRK00856 508765007308 Aspartate/ornithine carbamoyltransferase, carbamoyl-P binding domain; Region: OTCace_N; pfam02729 508765007309 Aspartate/ornithine carbamoyltransferase, Asp/Orn binding domain; Region: OTCace; pfam00185 508765007310 PyrR binding site 508765007311 undecaprenyl pyrophosphate phosphatase; Reviewed; Region: PRK00281 508765007312 TPR repeat; Region: TPR_11; pfam13414 508765007313 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 508765007314 binding surface 508765007315 TPR motif; other site 508765007316 TPR repeat; Region: TPR_11; pfam13414 508765007317 UDP-N-acetylmuramyl tripeptide synthase [Cell envelope biogenesis, outer membrane]; Region: MurE; COG0769 508765007318 Mur ligase middle domain; Region: Mur_ligase_M; pfam08245 508765007319 Domain of unknown function (DUF1727); Region: DUF1727; pfam08353 508765007320 Type 1 glutamine amidotransferase (GATase1) domain found in Cobyric Acid Synthase (CobQ); Region: GATase1_CobQ; cd01750 508765007321 catalytic triad [active] 508765007322 Predicted xylanase/chitin deacetylase [Carbohydrate transport and metabolism]; Region: CDA1; COG0726 508765007323 Catalytic NodB homology domain of Streptococcus mutans polysaccharide deacetylase PgdA, Bacillus subtilis YheN, and similar proteins; Region: CE4_SmPgdA_like; cd10944 508765007324 NodB motif; other site 508765007325 active site 508765007326 catalytic site [active] 508765007327 Zn binding site [ion binding]; other site 508765007328 Beta-lactamase enzyme family; Region: Beta-lactamase2; cl17872 508765007329 D-alanyl-D-alanine carboxypeptidase; Region: Peptidase_S11; pfam00768 508765007330 Conserved protein/domain typically associated with flavoprotein oxygenases, DIM6/NTAB family [General function prediction only]; Region: COG1853 508765007331 Arsenate Reductase (ArsC) family; composed of TRX-fold arsenic reductases and similar proteins including the transcriptional regulator, Spx. ArsC catalyzes the reduction of arsenate [As(V)] to arsenite [As(III)], using reducing equivalents derived from...; Region: ArsC_family; cd02977 508765007332 ArsC family; Region: ArsC; pfam03960 508765007333 catalytic residue [active] 508765007334 Fucose 4-O-acetylase and related acetyltransferases [Carbohydrate transport and metabolism]; Region: NolL; COG3594 508765007335 Acyltransferase family; Region: Acyl_transf_3; pfam01757 508765007336 SNARE associated Golgi protein; Region: SNARE_assoc; cl00429 508765007337 Uncharacterized membrane-associated protein [Function unknown]; Region: DedA; COG0586 508765007338 Na+-driven multidrug efflux pump [Defense mechanisms]; Region: NorM; COG0534 508765007339 Subfamily of the multidrug and toxic compound extrusion (MATE)-like proteins similar to Bacillus subtilis yoeA; Region: MATE_yoeA_like; cd13138 508765007340 glucan-binding repeat; Region: glucan_65_rpt; TIGR04035 508765007341 Putative cell wall binding repeat; Region: CW_binding_1; pfam01473 508765007342 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 508765007343 active site 508765007344 motif I; other site 508765007345 motif II; other site 508765007346 T-box leader 508765007347 Sodium:dicarboxylate symporter family; Region: SDF; pfam00375 508765007348 Na+/H+-dicarboxylate symporters [Energy production and conversion]; Region: GltP; COG1301 508765007349 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 508765007350 non-specific DNA binding site [nucleotide binding]; other site 508765007351 salt bridge; other site 508765007352 sequence-specific DNA binding site [nucleotide binding]; other site 508765007353 Periplasmic glucose/galactose-binding protein (GGBP) involved in chemotaxis towards, and active transport of, glucose and galactose in various bacterial species; Region: PBP1_GGBP; cd01539 508765007354 Periplasmic binding protein domain; Region: Peripla_BP_4; pfam13407 508765007355 ligand binding site [chemical binding]; other site 508765007356 calcium binding site [ion binding]; other site 508765007357 Clostridium thermocellum (Cth)TTM and similar proteins, a subgroup of the CYTH-like superfamily; Region: CYTH-like_CthTTM-like; cd07761 508765007358 putative active site [active] 508765007359 putative metal binding residues [ion binding]; other site 508765007360 signature motif; other site 508765007361 putative dimer interface [polypeptide binding]; other site 508765007362 putative phosphate binding site [ion binding]; other site 508765007363 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 508765007364 This conserved domain belongs to a superfamily including the bleomycin resistance protein, glyoxalase I, and type I ring-cleaving dioxygenases; Region: Glo_EDI_BRP_like_16; cd07263 508765007365 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 508765007366 non-specific DNA binding site [nucleotide binding]; other site 508765007367 salt bridge; other site 508765007368 sequence-specific DNA binding site [nucleotide binding]; other site 508765007369 hypothetical protein; Provisional; Region: PRK06771 508765007370 Methyltransferase domain; Region: Methyltransf_31; pfam13847 508765007371 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 508765007372 S-adenosylmethionine binding site [chemical binding]; other site 508765007373 Phosphotransferase enzyme family; Region: APH; pfam01636 508765007374 Aminoglycoside 3'-phosphotransferase (APH) and Choline Kinase (ChoK) family. The APH/ChoK family is part of a larger superfamily that includes the catalytic domains of other kinases, such as the typical serine/threonine/tyrosine protein kinases (PKs)...; Region: APH_ChoK_like; cl17270 508765007375 active site 508765007376 ATP binding site [chemical binding]; other site 508765007377 Chloride channel protein EriC [Inorganic ion transport and metabolism]; Region: EriC; COG0038 508765007378 ClC sycA-like chloride channel proteins. This ClC family presents in bacteria, where it facilitates acid resistance in acidic soil. Mutation of this gene (sycA) in Rhizobium tropici CIAT899 causes serious deficiencies in nodule development, nodulation...; Region: ClC_sycA_like; cd03682 508765007379 putative Cl- selectivity filter; other site 508765007380 putative pore gating glutamate residue; other site 508765007381 Uncharacterized subfamily of the multidrug and toxic compound extrusion (MATE) proteins; Region: MATE_like_1; cd13140 508765007382 Na+-driven multidrug efflux pump [Defense mechanisms]; Region: NorM; COG0534 508765007383 Type 1 glutamine amidotransferase (GATase1)-like domain; Region: GAT_1; cl00020 508765007384 Linear amide C-N hydrolases, choloylglycine hydrolase family; Region: CBAH; pfam02275 508765007385 Penicillin V acylase (PVA), also known as conjugated bile salt acid hydrolase (CBAH), catalyzes the hydrolysis of penicillin V to yield 6-amino penicillanic acid (6-APA), an important key intermediate of semisynthetic penicillins. PVA has an N-terminal...; Region: Ntn_PVA; cd00542 508765007386 active site 508765007387 Xanthine/uracil/vitamin C permease [Nucleotide transport and metabolism]; Region: COG2252 508765007388 Protein of unknown function (DUF3791); Region: DUF3791; pfam12668 508765007389 Protein of unknown function (DUF3990); Region: DUF3990; pfam13151 508765007390 Protein of unknown function (DUF3791); Region: DUF3791; pfam12668 508765007391 YvrJ protein family; Region: YvrJ; pfam12841 508765007392 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 508765007393 Coenzyme A binding pocket [chemical binding]; other site 508765007394 Protein of unknown function (DUF1659); Region: DUF1659; pfam07872 508765007395 Protein of unknown function (DUF2922); Region: DUF2922; pfam11148 508765007396 SEC-C motif; Region: SEC-C; pfam02810 508765007397 Tetratricopeptide repeat; Region: TPR_12; pfam13424 508765007398 SEC-C motif; Region: SEC-C; pfam02810 508765007399 ABC-type nitrate/sulfonate/bicarbonate transport systems, periplasmic components [Inorganic ion transport and metabolism]; Region: TauA; COG0715 508765007400 NMT1-like family; Region: NMT1_2; pfam13379 508765007401 ABC-type nitrate/sulfonate/bicarbonate transport system, ATPase component [Inorganic ion transport and metabolism]; Region: TauB; COG1116 508765007402 ATP-binding cassette domain of the nitrate and sulfonate transporters; Region: ABC_NrtD_SsuB_transporters; cd03293 508765007403 Walker A/P-loop; other site 508765007404 ATP binding site [chemical binding]; other site 508765007405 Q-loop/lid; other site 508765007406 ABC transporter signature motif; other site 508765007407 Walker B; other site 508765007408 D-loop; other site 508765007409 H-loop/switch region; other site 508765007410 ABC-type nitrate/sulfonate/bicarbonate transport system, permease component [Inorganic ion transport and metabolism]; Region: TauC; COG0600 508765007411 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 508765007412 dimer interface [polypeptide binding]; other site 508765007413 conserved gate region; other site 508765007414 putative PBP binding loops; other site 508765007415 ABC-ATPase subunit interface; other site 508765007416 Putative effector of murein hydrolase LrgA [General function prediction only]; Region: COG1380 508765007417 LrgB-like family; Region: LrgB; pfam04172 508765007418 DNA topoisomerase III; Provisional; Region: PRK07726 508765007419 TOPRIM_TopoIA_TopoIII: The topoisomerase-primase (TORPIM) domain found in members of the type IA family of DNA topoisomerases (Topo IA) similar to topoisomerase III. Type IA DNA topoisomerases remove (relax) negative supercoils in the DNA by: cleaving...; Region: TOPRIM_TopoIA_TopoIII; cd03362 508765007420 active site 508765007421 putative interdomain interaction site [polypeptide binding]; other site 508765007422 putative metal-binding site [ion binding]; other site 508765007423 putative nucleotide binding site [chemical binding]; other site 508765007424 DNA Topoisomerase, subtype IA; DNA-binding, ATP-binding and catalytic domain of bacterial DNA topoisomerases I and III, and eukaryotic DNA topoisomerase III and eubacterial and archael reverse gyrases. Topoisomerases clevage single or double stranded DNA...; Region: TOP1Ac; cl11986 508765007425 domain I; other site 508765007426 DNA binding groove [nucleotide binding] 508765007427 phosphate binding site [ion binding]; other site 508765007428 domain II; other site 508765007429 domain III; other site 508765007430 nucleotide binding site [chemical binding]; other site 508765007431 catalytic site [active] 508765007432 domain IV; other site 508765007433 C-terminal repeat of topoisomerase; Region: Toprim_Crpt; pfam13342 508765007434 TspO/MBR family; Region: TspO_MBR; pfam03073 508765007435 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 508765007436 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 508765007437 dimer interface [polypeptide binding]; other site 508765007438 phosphorylation site [posttranslational modification] 508765007439 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 508765007440 ATP binding site [chemical binding]; other site 508765007441 Mg2+ binding site [ion binding]; other site 508765007442 G-X-G motif; other site 508765007443 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 508765007444 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 508765007445 dimer interface [polypeptide binding]; other site 508765007446 phosphorylation site [posttranslational modification] 508765007447 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 508765007448 ATP binding site [chemical binding]; other site 508765007449 Mg2+ binding site [ion binding]; other site 508765007450 G-X-G motif; other site 508765007451 Predicted membrane protein [Function unknown]; Region: COG1511 508765007452 YhgE/Pip N-terminal domain; Region: pip_yhgE_Nterm; TIGR03061 508765007453 YhgE/Pip C-terminal domain; Region: pip_yhgE_Cterm; TIGR03062 508765007454 Predicted membrane protein [Function unknown]; Region: COG1511 508765007455 YhgE/Pip N-terminal domain; Region: pip_yhgE_Nterm; TIGR03061 508765007456 YhgE/Pip C-terminal domain; Region: pip_yhgE_Cterm; TIGR03062 508765007457 Glycosyl hydrolases family 8; Region: Glyco_hydro_8; cl01351 508765007458 Soluble lytic murein transglycosylase and related regulatory proteins (some contain LysM/invasin domains) [Cell envelope biogenesis, outer membrane]; Region: MltE; COG0741 508765007459 Lytic Transglycosylase (LT) and Goose Egg White Lysozyme (GEWL) domain. Members include the soluble and insoluble membrane-bound LTs in bacteria, the LTs in bacteriophage lambda, as well as, the eukaryotic "goose-type" lysozymes (GEWL). LTs...; Region: LT_GEWL; cd00254 508765007460 N-acetyl-D-glucosamine binding site [chemical binding]; other site 508765007461 catalytic residue [active] 508765007462 Dephospho-CoA kinase [Coenzyme metabolism]; Region: CoaE; COG0237 508765007463 Dephospho-coenzyme A kinase (DPCK, EC 2.7.1.24) catalyzes the phosphorylation of dephosphocoenzyme A (dCoA) to yield CoA, which is the final step in CoA biosynthesis; Region: DPCK; cd02022 508765007464 CoA-binding site [chemical binding]; other site 508765007465 DNA polymerase I; Provisional; Region: PRK05755 508765007466 PIN domain of the 5'-3' exonuclease of Taq DNA polymerase I and homologs; Region: PIN_53EXO; cd09859 508765007467 active site 508765007468 metal binding site 1 [ion binding]; metal-binding site 508765007469 putative 5' ssDNA interaction site; other site 508765007470 metal binding site 3; metal-binding site 508765007471 metal binding site 2 [ion binding]; metal-binding site 508765007472 H3TH domain of the 5'-3' exonuclease of Taq DNA polymerase I and homologs; Region: H3TH_53EXO; cd09898 508765007473 putative DNA binding site [nucleotide binding]; other site 508765007474 putative metal binding site [ion binding]; other site 508765007475 inactive DEDDy 3'-5' exonuclease domain of Bacillus stearothermophilus DNA polymerase I and similar family-A DNA polymerases; Region: DNA_polA_I_Bacillus_like_exo; cd06140 508765007476 Polymerase I functions primarily to fill DNA gaps that arise during DNA repair, recombination and replication; Region: DNA_pol_A_pol_I_C; cd08637 508765007477 active site 508765007478 DNA binding site [nucleotide binding] 508765007479 catalytic site [active] 508765007480 Leucyl aminopeptidase (aminopeptidase T) [Amino acid transport and metabolism]; Region: AmpS; COG2309 508765007481 Thermophilic metalloprotease (M29); Region: Peptidase_M29; pfam02073 508765007482 Trimeric dUTP diphosphatases; Region: trimeric_dUTPase; cd07557 508765007483 trimer interface [polypeptide binding]; other site 508765007484 active site 508765007485 isocitrate dehydrogenase; Validated; Region: PRK08299 508765007486 Predicted membrane protein [Function unknown]; Region: COG2855 508765007487 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 508765007488 putative DNA-binding transcriptional regulator; Provisional; Region: PRK10837 508765007489 C-terminal substrate binding domain of LysR-type transcriptional regulator CysL, which activates the transcription of the cysJI operon encoding sulfite reductase, contains the type 2 periplasmic binding fold; Region: PBP2_CysL_like; cd08420 508765007490 putative dimerization interface [polypeptide binding]; other site 508765007491 Four helix bundle sensory module for signal transduction; Region: 4HB_MCP_1; pfam12729 508765007492 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cl01054 508765007493 dimerization interface [polypeptide binding]; other site 508765007494 Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer); Region: MA; smart00283 508765007495 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 508765007496 dimer interface [polypeptide binding]; other site 508765007497 putative CheW interface [polypeptide binding]; other site 508765007498 ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653 508765007499 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; pfam01547 508765007500 ABC-type polysaccharide transport system, permease component [Carbohydrate transport and metabolism]; Region: LplB; COG4209 508765007501 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 508765007502 dimer interface [polypeptide binding]; other site 508765007503 conserved gate region; other site 508765007504 putative PBP binding loops; other site 508765007505 ABC-ATPase subunit interface; other site 508765007506 ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395 508765007507 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 508765007508 dimer interface [polypeptide binding]; other site 508765007509 conserved gate region; other site 508765007510 putative PBP binding loops; other site 508765007511 ABC-ATPase subunit interface; other site 508765007512 A new structural DNA glycosylase; Region: AlkD_like; cd06561 508765007513 active site 508765007514 Cache domain; Region: Cache_1; pfam02743 508765007515 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 508765007516 dimerization interface [polypeptide binding]; other site 508765007517 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 508765007518 Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer); Region: MA; smart00283 508765007519 dimer interface [polypeptide binding]; other site 508765007520 putative CheW interface [polypeptide binding]; other site 508765007521 Mannosyl-glycoprotein endo-beta-N-acetylglucosaminidase; Region: Glucosaminidase; pfam01832 508765007522 glucan-binding repeat; Region: glucan_65_rpt; TIGR04035 508765007523 Putative cell wall binding repeat; Region: CW_binding_1; pfam01473 508765007524 glucan-binding repeat; Region: glucan_65_rpt; TIGR04035 508765007525 glucan-binding repeat; Region: glucan_65_rpt; TIGR04035 508765007526 N-acetylmuramoyl-L-alanine amidase [Cell envelope biogenesis, outer membrane]; Region: AmiC; COG0860 508765007527 N-acetylmuramoyl-L-alanine amidase or MurNAc-LAA (also known as peptidoglycan aminohydrolase, NAMLA amidase, NAMLAA, Amidase 3, and peptidoglycan amidase; EC 3.5.1.28) is an autolysin that hydrolyzes the amide bond between N-acetylmuramoyl and L-amino...; Region: MurNAc-LAA; cd02696 508765007528 active site 508765007529 metal binding site [ion binding]; metal-binding site 508765007530 PilZ domain; Region: PilZ; pfam07238 508765007531 Bacterial cell division membrane protein [Cell division and chromosome partitioning]; Region: FtsW; COG0772 508765007532 Predicted transcriptional regulators [Transcription]; Region: COG1695 508765007533 Transcriptional regulator PadR-like family; Region: PadR; pfam03551 508765007534 RNA polymerase sigma factor, sigma-70 family; Region: sigma70-ECF; TIGR02937 508765007535 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 508765007536 Sigma-70, region 4; Region: Sigma70_r4_2; pfam08281 508765007537 DNA binding residues [nucleotide binding] 508765007538 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 508765007539 haloacid dehalogenase-like hydrolase; Region: Hydrolase_3; pfam08282 508765007540 active site 508765007541 motif I; other site 508765007542 motif II; other site 508765007543 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cl17915 508765007544 YdcF-like. YdcF-like is a large family of mainly bacterial proteins, with a few members found in fungi, plants, and archaea. Escherichia coli YdcF has been shown to bind S-adenosyl-L-methionine (AdoMet), but a biochemical function has not been...; Region: YdcF-like; cl00630 508765007545 putative active site [active] 508765007546 Domain of unknown function (DUF4367); Region: DUF4367; pfam14285 508765007547 RNA polymerase sigma-70 factor, TIGR02952 family; Region: Sig70_famx2 508765007548 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 508765007549 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 508765007550 DNA binding residues [nucleotide binding] 508765007551 AAA domain; Region: AAA_33; pfam13671 508765007552 AAA domain; Region: AAA_17; pfam13207 508765007553 Acetyltransferase (GNAT) domain; Region: Acetyltransf_10; pfam13673 508765007554 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 508765007555 Coenzyme A binding pocket [chemical binding]; other site 508765007556 Nudix hydrolase is a superfamily of enzymes found in all three kingdoms of life, and it catalyzes the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+...; Region: Nudix_Hydrolase; cl00447 508765007557 nudix motif; other site 508765007558 TfoX C-terminal domain; Region: TfoX_C; pfam04994 508765007559 GAD-like domain; Region: GAD-like; pfam08887 508765007560 Domain of unknown function (DUF1851); Region: DUF1851; pfam08906 508765007561 Domain of unknown function (DUF4272); Region: DUF4272; pfam14094 508765007562 Suppressor of fused protein (SUFU); Region: SUFU; pfam05076 508765007563 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 508765007564 HAMP domain; Region: HAMP; pfam00672 508765007565 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 508765007566 dimer interface [polypeptide binding]; other site 508765007567 phosphorylation site [posttranslational modification] 508765007568 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 508765007569 ATP binding site [chemical binding]; other site 508765007570 Mg2+ binding site [ion binding]; other site 508765007571 G-X-G motif; other site 508765007572 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 508765007573 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 508765007574 active site 508765007575 phosphorylation site [posttranslational modification] 508765007576 intermolecular recognition site; other site 508765007577 dimerization interface [polypeptide binding]; other site 508765007578 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 508765007579 DNA binding site [nucleotide binding] 508765007580 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 508765007581 S-adenosylmethionine binding site [chemical binding]; other site 508765007582 NADH:flavin oxidoreductases, Old Yellow Enzyme family [Energy production and conversion]; Region: NemA; COG1902 508765007583 Old yellow enzyme (OYE)-like FMN binding domain. OYE was the first flavin-dependent enzyme identified, however its true physiological role remains elusive to this day. Each monomer of OYE contains FMN as a non-covalently bound cofactor, uses NADPH as a...; Region: OYE_like_FMN_family; cd02803 508765007584 active site 508765007585 FMN binding site [chemical binding]; other site 508765007586 substrate binding site [chemical binding]; other site 508765007587 putative catalytic residue [active] 508765007588 Predicted transcriptional regulators [Transcription]; Region: COG1733 508765007589 HxlR-like helix-turn-helix; Region: HxlR; pfam01638 508765007590 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3878 508765007591 stage V sporulation protein K; Region: spore_V_K; TIGR02881 508765007592 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cl17189 508765007593 stage V sporulation protein K; Region: spore_V_K; TIGR02881 508765007594 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 508765007595 Walker A motif; other site 508765007596 ATP binding site [chemical binding]; other site 508765007597 Walker B motif; other site 508765007598 arginine finger; other site 508765007599 stage V sporulation protein K; Region: spore_V_K; TIGR02881 508765007600 Polypeptide or peptide deformylase; a family of metalloenzymes that catalyzes the removal of the N-terminal formyl group in a growing polypeptide chain following translation initiation during protein synthesis in prokaryotes. These enzymes utilize Fe(II)...; Region: Pep_deformylase; cd00487 508765007601 active site 508765007602 catalytic residues [active] 508765007603 metal binding site [ion binding]; metal-binding site 508765007604 H+ Antiporter protein; Region: 2A0121; TIGR00900 508765007605 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 508765007606 putative substrate translocation pore; other site 508765007607 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 508765007608 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 508765007609 Protein of unknown function (DUF3189); Region: DUF3189; pfam11385 508765007610 Domain of unknown function (DUF4097); Region: DUF4097; pfam13349 508765007611 Membrane protein of unknown function; Region: DUF360; pfam04020 508765007612 Small, acid-soluble spore proteins, alpha/beta type; Region: SASP; pfam00269 508765007613 Peptidase S8 family domain in CspA-like proteins; Region: Peptidases_S8_CspA-like; cd07478 508765007614 active site 508765007615 catalytic triad [active] 508765007616 Subtilisin-like serine proteases [Posttranslational modification, protein turnover, chaperones]; Region: AprE; COG1404 508765007617 Peptidase S8 family domain in CspA-like proteins; Region: Peptidases_S8_CspA-like; cd07478 508765007618 active site 508765007619 catalytic triad [active] 508765007620 LexA DNA binding domain; Region: LexA_DNA_bind; pfam01726 508765007621 Putative cell wall binding repeat; Region: CW_binding_1; pfam01473 508765007622 lysozyme_like domain. This contains several members including Soluble Lytic Transglycosylases (SLT), Goose Egg-White Lysozymes (GEWL), Hen Egg-White Lysozymes (HEWL), chitinases, bacteriophage lambda lysozymes, endolysins, autolysins, and chitosanases; Region: lysozyme_like; cl00222 508765007623 catalytic residue [active] 508765007624 Haemolysin XhlA; Region: XhlA; pfam10779 508765007625 Bacterial surface proteins containing Ig-like domains [Cell motility and secretion]; Region: COG5492 508765007626 Bacterial Ig-like domain (group 2); Region: Big_2; pfam02368 508765007627 Bacterial surface proteins containing Ig-like domains [Cell motility and secretion]; Region: COG5492 508765007628 Bacterial Ig-like domain (group 2); Region: Big_2; cl02708 508765007629 Domain of unknown function DUF11; Region: DUF11; pfam01345 508765007630 Phage uncharacterized protein (Phage_XkdX); Region: Phage_XkdX; cl09900 508765007631 Phage tail-collar fibre protein; Region: DUF3751; pfam12571 508765007632 Phage tail fibre repeat; Region: Phage_fiber_2; pfam03406 508765007633 Uncharacterized protein conserved in bacteria (DUF2313); Region: DUF2313; cl01542 508765007634 Baseplate J-like protein; Region: Baseplate_J; pfam04865 508765007635 Protein of unknown function (DUF2634); Region: DUF2634; pfam10934 508765007636 Bacterial SH3 domain; Region: SH3_3; pfam08239 508765007637 Domain of unknown function (DUF4352); Region: DUF4352; pfam11611 508765007638 phage tail tape measure protein, TP901 family, core region; Region: tape_meas_TP901; TIGR01760 508765007639 Phage XkdN-like protein; Region: XkdN; pfam08890 508765007640 Protein of unknown function (DUF2001); Region: DUF2001; pfam09393 508765007641 Phage tail sheath protein; Region: Phage_sheath_1; pfam04984 508765007642 Phage major capsid protein E; Region: Phage_cap_E; pfam03864 508765007643 Phage minor structural protein GP20; Region: Phage_GP20; pfam06810 508765007644 Phage Mu protein F like protein; Region: Phage_Mu_F; cl10072 508765007645 Phage portal protein, SPP1 Gp6-like; Region: Phage_prot_Gp6; pfam05133 508765007646 Phage terminase large subunit; Region: Terminase_3; cl12054 508765007647 Terminase-like family; Region: Terminase_6; pfam03237 508765007648 Sigma-70, region 4; Region: Sigma70_r4_2; pfam08281 508765007649 Terminase small subunit; Region: Terminase_2; cl01513 508765007650 Coat F domain; Region: Coat_F; pfam07875 508765007651 Spore coat protein [Cell envelope biogenesis, outer membrane]; Region: COG5577 508765007652 Manganese catalase, ferritin-like diiron-binding domain; Region: Mn_catalase; cd01051 508765007653 Uncharacterized conserved protein [Function unknown]; Region: COG1633 508765007654 dimanganese center [ion binding]; other site 508765007655 Membrane protein of unknown function; Region: DUF360; pfam04020 508765007656 Small, acid-soluble spore proteins, alpha/beta type; Region: SASP; pfam00269 508765007657 phage transcriptional activator, RinA family; Region: phage_rinA; TIGR01636 508765007658 Recombination protein U; Region: RecU; cl01314 508765007659 BRO family, N-terminal domain; Region: Bro-N; cl10591 508765007660 ORF6C domain; Region: ORF6C; pfam10552 508765007661 37-kD nucleoid-associated bacterial protein; Region: NA37; pfam04245 508765007662 tyrosine recombinase XerC; Region: recomb_XerC; TIGR02224 508765007663 DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213 508765007664 active site 508765007665 DNA binding site [nucleotide binding] 508765007666 Int/Topo IB signature motif; other site 508765007667 This domain is found in phosphoadenosine phosphosulphate (PAPS) reductase enzymes or PAPS sulphotransferase. PAPS reductase is part of the adenine nucleotide alpha hydrolases superfamily also including N type ATP PPases and ATP sulphurylases. A highly...; Region: PAPS_reductase; cd01713 508765007668 Active Sites [active] 508765007669 Domain of Unknown Function with PDB structure (DUF3850); Region: DUF3850; pfam12961 508765007670 Single-stranded DNA-binding protein [DNA replication, recombination, and repair]; Region: Ssb; COG0629 508765007671 SSB_OBF: A subfamily of OB folds similar to the OB fold of ssDNA-binding protein (SSB). SSBs bind with high affinity to ssDNA. They bind to and protect ssDNA intermediates during DNA metabolic pathways. All bacterial and eukaryotic SSBs studied to date...; Region: SSB_OBF; cd04496 508765007672 dimer interface [polypeptide binding]; other site 508765007673 ssDNA binding site [nucleotide binding]; other site 508765007674 tetramer (dimer of dimers) interface [polypeptide binding]; other site 508765007675 HNH endonuclease; Region: HNH_3; pfam13392 508765007676 Replication initiation and membrane attachment; Region: DnaB_2; cl12121 508765007677 Metallo-beta-lactamase superfamily; Region: Lactamase_B; cl00446 508765007678 RecT family; Region: RecT; cl04285 508765007679 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 508765007680 AAA domain; Region: AAA_23; pfam13476 508765007681 Walker A/P-loop; other site 508765007682 ATP binding site [chemical binding]; other site 508765007683 Q-loop/lid; other site 508765007684 Helix-turn-helix domain; Region: HTH_17; pfam12728 508765007685 BRO family, N-terminal domain; Region: Bro-N; cl10591 508765007686 Phage antirepressor protein KilAC domain; Region: ANT; pfam03374 508765007687 Protein of unknown function (DUF739); Region: DUF739; pfam05339 508765007688 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 508765007689 non-specific DNA binding site [nucleotide binding]; other site 508765007690 salt bridge; other site 508765007691 sequence-specific DNA binding site [nucleotide binding]; other site 508765007692 Domain of unknown function (DUF955); Region: DUF955; pfam06114 508765007693 DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213 508765007694 tyrosine recombinase XerC; Region: recomb_XerC; TIGR02224 508765007695 phiLC3 phage and phage-related integrases, site-specific recombinases, DNA breaking-rejoining enzymes, C-terminal catalytic domain. This CD includes various bacterial (mainly gram positive) and phage integrases, including those similar to Lactococcus...; Region: INT_phiLC3_C; cd01189 508765007696 Int/Topo IB signature motif; other site 508765007697 GGGtGRT protein; Region: GGGtGRT; pfam14057 508765007698 NifU homolog involved in Fe-S cluster formation [Energy production and conversion]; Region: IscU; COG0822 508765007699 Iron-sulfur cluster scaffold-like proteins; Region: IscU_like; cl00528 508765007700 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4868 508765007701 hypothetical protein; Provisional; Region: PRK13663 508765007702 metallophosphatase superfamily, metallophosphatase domain; Region: MPP_superfamily; cl13995 508765007703 active site 508765007704 metal binding site [ion binding]; metal-binding site 508765007705 Protein of unknown function (DUF554); Region: DUF554; pfam04474 508765007706 Protein kinase domain; Region: Pkinase; pfam00069 508765007707 Catalytic domain of Protein Kinases; Region: PKc; cd00180 508765007708 active site 508765007709 ATP binding site [chemical binding]; other site 508765007710 substrate binding site [chemical binding]; other site 508765007711 activation loop (A-loop); other site 508765007712 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 508765007713 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 508765007714 metal binding site [ion binding]; metal-binding site 508765007715 active site 508765007716 I-site; other site 508765007717 Cytochrome c biogenesis protein [Posttranslational modification, protein turnover, chaperones]; Region: CcdA; COG0785 508765007718 Cytochrome C biogenesis protein transmembrane region; Region: DsbD; pfam02683 508765007719 TlpA-like family; composed of TlpA, ResA, DsbE and similar proteins. TlpA, ResA and DsbE are bacterial protein disulfide reductases with important roles in cytochrome maturation. They are membrane-anchored proteins with a soluble TRX domain containing a...; Region: TlpA_like_family; cd02966 508765007720 Thioredoxin-like; Region: Thioredoxin_8; pfam13905 508765007721 catalytic residues [active] 508765007722 TRX family; composed of two groups: Group I, which includes proteins that exclusively encode a TRX domain; and Group II, which are composed of fusion proteins of TRX and additional domains. Group I TRX is a small ancient protein that alter the redox...; Region: TRX_family; cd02947 508765007723 Thioredoxin-like; Region: Thioredoxin_8; pfam13905 508765007724 catalytic residues [active] 508765007725 Thiol-activated cytolysin; Region: Thiol_cytolysin; pfam01289 508765007726 Polyferredoxin [Energy production and conversion]; Region: NapH; COG0348 508765007727 4Fe-4S binding domain; Region: Fer4_5; pfam12801 508765007728 ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other...; Region: ANK; cd00204 508765007729 Ankyrin repeats (many copies); Region: Ank_4; pfam13637 508765007730 Copper amine oxidase N-terminal domain; Region: Cu_amine_oxidN1; pfam07833 508765007731 EcsC protein family; Region: EcsC; pfam12787 508765007732 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 508765007733 Coenzyme A binding pocket [chemical binding]; other site 508765007734 Permeases of the drug/metabolite transporter (DMT) superfamily [Carbohydrate transport and metabolism / Amino acid transport and metabolism / General function prediction only]; Region: RhaT; COG0697 508765007735 EamA-like transporter family; Region: EamA; pfam00892 508765007736 signal peptidase I, bacterial type; Region: sigpep_I_bact; TIGR02227 508765007737 The S26 Type I signal peptidase (SPase; LepB; leader peptidase B; leader peptidase I; EC 3.4.21.89) family members are essential membrane-bound serine proteases that function to cleave the amino-terminal signal peptide extension from proteins that are...; Region: S26_SPase_I; cd06530 508765007738 Catalytic site [active] 508765007739 myosin-cross-reactive antigen; Provisional; Region: PRK13977 508765007740 Beta-lactamase enzyme family; Region: Beta-lactamase2; pfam13354 508765007741 ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136 508765007742 ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255 508765007743 Walker A/P-loop; other site 508765007744 ATP binding site [chemical binding]; other site 508765007745 Q-loop/lid; other site 508765007746 ABC transporter signature motif; other site 508765007747 Walker B; other site 508765007748 D-loop; other site 508765007749 H-loop/switch region; other site 508765007750 RND family efflux transporter, MFP subunit; Region: RND_mfp; TIGR01730 508765007751 HlyD family secretion protein; Region: HlyD_3; pfam13437 508765007752 BioY family; Region: BioY; pfam02632 508765007753 Rubredoxin, Small Modular nonheme iron binding domain containing a [Fe(SCys)4] center, present in rubrerythrin and nigerythrin and detected either N- or C-terminal to such proteins as flavin reductase, NAD(P)H-nitrite reductase, and...; Region: rubredoxin_SM; cd00729 508765007754 Rubredoxin; Region: Rubredoxin; pfam00301 508765007755 iron binding site [ion binding]; other site 508765007756 rubrerythrin-like, diiron-binding domain; Region: Rubrerythrin_like; cd01046 508765007757 Rubrerythrin [Energy production and conversion]; Region: COG1592 508765007758 diiron binding motif [ion binding]; other site 508765007759 Rubredoxin, Small Modular nonheme iron binding domain containing a [Fe(SCys)4] center, present in rubrerythrin and nigerythrin and detected either N- or C-terminal to such proteins as flavin reductase, NAD(P)H-nitrite reductase, and...; Region: rubredoxin_SM; cd00729 508765007760 Rubredoxin; Region: Rubredoxin; pfam00301 508765007761 iron binding site [ion binding]; other site 508765007762 rubrerythrin-like, diiron-binding domain; Region: Rubrerythrin_like; cd01046 508765007763 Rubrerythrin [Energy production and conversion]; Region: COG1592 508765007764 diiron binding motif [ion binding]; other site 508765007765 Pyruvate kinase (PK): Large allosteric enzyme that regulates glycolysis through binding of the substrate, phosphoenolpyruvate, and one or more allosteric effectors. Like other allosteric enzymes, PK has a high substrate affinity R state and a low...; Region: Pyruvate_Kinase; cl17342 508765007766 active site 508765007767 domain interfaces; other site 508765007768 Predicted metal-dependent phosphoesterases (PHP family) [General function prediction only]; Region: COG0613 508765007769 Polymerase and Histidinol Phosphatase domain of Histidinol phosphate phosphatase (HisPPase) AMP bound; Region: PHP_HisPPase_AMP; cd07438 508765007770 active site 508765007771 Polymerase and Histidinol Phosphatase domain; Region: PHP; cl17102 508765007772 Bacteriophage holin; Region: Phage_holin_1; cl02344 508765007773 M18 Peptidase Aminopeptidase I; Region: M18_API; cd05659 508765007774 Aminopeptidase I zinc metalloprotease (M18); Region: Peptidase_M18; pfam02127 508765007775 oligomer interface [polypeptide binding]; other site 508765007776 putative active site [active] 508765007777 metal binding site [ion binding]; metal-binding site 508765007778 HPr kinase/phosphorylase; Provisional; Region: PRK05428 508765007779 HPr Serine kinase N terminus; Region: Hpr_kinase_N; pfam02603 508765007780 HprK/P, the bifunctional histidine-containing protein kinase/phosphatase, controls the phosphorylation state of the phosphocarrier protein HPr and regulates the utilization of carbon sources by gram-positive bacteria. It catalyzes both the ATP-dependent...; Region: HprK_C; cd01918 508765007781 Hpr binding site; other site 508765007782 active site 508765007783 homohexamer subunit interaction site [polypeptide binding]; other site 508765007784 Bacterial protein of unknown function (DUF896); Region: DUF896; pfam05979 508765007785 hypothetical protein; Provisional; Region: PRK13678 508765007786 Superfamily I DNA and RNA helicases [General function prediction only]; Region: COG3973 508765007787 Part of AAA domain; Region: AAA_19; pfam13245 508765007788 Family description; Region: UvrD_C_2; pfam13538 508765007789 Methionine synthase I (cobalamin-dependent), methyltransferase domain [Amino acid transport and metabolism]; Region: MetH; cl14105 508765007790 Homocysteine S-methyltransferase; Region: S-methyl_trans; pfam02574 508765007791 Pterin binding enzymes. This family includes dihydropteroate synthase (DHPS) and cobalamin-dependent methyltransferases such as methyltetrahydrofolate, corrinoid iron-sulfur protein methyltransferase (MeTr) and methionine synthase (MetH). DHPS, a...; Region: Pterin_binding; cl00219 508765007792 substrate binding pocket [chemical binding]; other site 508765007793 dimer interface [polypeptide binding]; other site 508765007794 inhibitor binding site; inhibition site 508765007795 B12 binding domain of corrinoid proteins. A family of small methanogenic corrinoid proteins that bind methyl-Co(III) 5-hydroxybenzimidazolylcobamide as a cofactor. They play a role on the methanogenesis from trimethylamine, dimethylamine or...; Region: corrinoid_protein_B12-BD; cd02070 508765007796 methyltransferase cognate corrinoid proteins, Methanosarcina family; Region: pyl_corrinoid; TIGR02370 508765007797 B12 binding site [chemical binding]; other site 508765007798 cobalt ligand [ion binding]; other site 508765007799 Vitamin B12 dependent methionine synthase, activation domain; Region: Met_synt_B12; pfam02965 508765007800 S-ribosylhomocysteinase; Provisional; Region: PRK02260 508765007801 Methylenetetrahydrofolate reductase (MTHFR). 5,10-Methylenetetrahydrofolate is reduced to 5-methyltetrahydrofolate by methylenetetrahydrofolate reductase, a cytoplasmic, NAD(P)-dependent enzyme. 5-methyltetrahydrofolate is utilized by methionine synthase...; Region: MTHFR; cd00537 508765007802 FAD binding site [chemical binding]; other site 508765007803 phospho-N-acetylmuramoyl-pentapeptide-transferase; Region: mraY; TIGR00445 508765007804 This subfamily contains Escherichia coli WecA, Bacillus subtilis TagO and related proteins. WecA is an UDP-N-acetylglucosamine (GlcNAc):undecaprenyl-phosphate (Und-P) GlcNAc-1-phosphate transferase that catalyzes the formation of a phosphodiester bond...; Region: GT_WecA_like; cd06853 508765007805 Mg++ binding site [ion binding]; other site 508765007806 putative catalytic motif [active] 508765007807 substrate binding site [chemical binding]; other site 508765007808 5'-nucleotidase/2',3'-cyclic phosphodiesterase and related esterases [Nucleotide transport and metabolism]; Region: UshA; COG0737 508765007809 Staphylococcus aureus SA0022 and related proteins, N-terminal metallophosphatase domain; Region: MPP_SA0022_N; cd07408 508765007810 putative active site [active] 508765007811 putative metal binding site [ion binding]; other site 508765007812 5'-nucleotidase, C-terminal domain; Region: 5_nucleotid_C; pfam02872 508765007813 Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118 508765007814 V-type ATP synthase subunit D; Reviewed; Region: PRK00373 508765007815 V-type ATP synthase subunit B; Provisional; Region: PRK04196 508765007816 ATP synthase alpha/beta family, beta-barrel domain; Region: ATP-synt_ab_N; pfam02874 508765007817 V/A-type ATP synthase (non-catalytic) subunit B. These ATPases couple ATP hydrolysis to the build up of a H+ gradient, but V-type ATPases do not catalyze the reverse reaction. The Vacuolar (V-type) ATPase is found in the membranes of vacuoles, the golgi...; Region: V_A-ATPase_B; cd01135 508765007818 Walker A motif homologous position; other site 508765007819 Walker B motif; other site 508765007820 ATP synthase alpha/beta chain, C terminal domain; Region: ATP-synt_ab_C; pfam00306 508765007821 V-type ATP synthase subunit A; Provisional; Region: PRK04192 508765007822 ATP synthase alpha/beta family, beta-barrel domain; Region: ATP-synt_ab_N; pfam02874 508765007823 V/A-type ATP synthase catalytic subunit A. These ATPases couple ATP hydrolysis to the build up of a H+ gradient, but V-type ATPases do not catalyze the reverse reaction. The Vacuolar (V-type) ATPase is found in the membranes of vacuoles, the golgi...; Region: V_A-ATPase_A; cd01134 508765007824 Walker A motif/ATP binding site; other site 508765007825 Walker B motif; other site 508765007826 ATP synthase alpha/beta chain, C terminal domain; Region: ATP-synt_ab_C; pfam00306 508765007827 V-type ATP synthase subunit F; Provisional; Region: PRK01395 508765007828 V-type ATP synthase subunit C; Provisional; Region: PRK01198 508765007829 Archaeal/vacuolar-type H+-ATPase subunit C [Energy production and conversion]; Region: NtpC; COG1527 508765007830 V-type ATP synthase subunit E; Provisional; Region: PRK03963; cl17074 508765007831 V-type ATP synthase subunit K; Validated; Region: PRK06558 508765007832 ATP synthase subunit C; Region: ATP-synt_C; pfam00137 508765007833 ATP synthase subunit C; Region: ATP-synt_C; pfam00137 508765007834 V-type ATP synthase subunit I; Validated; Region: PRK05771 508765007835 ATP synthase B/B' CF(0); Region: ATP-synt_B; cl17192 508765007836 Fe-S oxidoreductase [Energy production and conversion]; Region: COG1032 508765007837 B12 binding domain (B12-BD). Most of the members bind different cobalamid derivates, like B12 (adenosylcobamide) or methylcobalamin or methyl-Co(III) 5-hydroxybenzimidazolylcobamide. This domain is found in several enzymes, such as glutamate mutase; Region: B12-binding_like; cl00293 508765007838 B12 binding site [chemical binding]; other site 508765007839 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 508765007840 FeS/SAM binding site; other site 508765007841 Protein of unknown function (DUF4080); Region: DUF4080; pfam13311 508765007842 Glucose/sorbosone dehydrogenases [Carbohydrate transport and metabolism]; Region: COG2133 508765007843 stage V sporulation protein B; Region: spore_V_B; TIGR02900 508765007844 Multidrug and toxic compound extrusion family and similar proteins; Region: MATE_like; cl09326 508765007845 stage V sporulation protein B; Region: spore_V_B; TIGR02900 508765007846 Stage V sporulation protein B, also known as Stage III sporulation protein F, and related proteins; Region: MATE_SpoVB_like; cd13124 508765007847 Pseudouridylate synthases, 23S RNA-specific [Translation, ribosomal structure and biogenesis]; Region: RluA; COG0564 508765007848 Pseudouridine synthase, RsuA/RluD family; Region: PseudoU_synth_RluCD_like; cd02869 508765007849 active site 508765007850 Metal-dependent amidase/aminoacylase/carboxypeptidase [General function prediction only]; Region: AbgB; COG1473 508765007851 M20 Peptidase Aminoacylase 1 family; Region: M20_Acy1; cd03886 508765007852 metal binding site [ion binding]; metal-binding site 508765007853 dimer interface [polypeptide binding]; other site 508765007854 cell division protein FtsA; Region: ftsA; TIGR01174 508765007855 Cell division protein FtsA; Region: FtsA; smart00842 508765007856 Cell division protein FtsA; Region: FtsA; pfam14450 508765007857 Superfamily I DNA and RNA helicases [DNA replication, recombination, and repair]; Region: UvrD; COG0210 508765007858 Part of AAA domain; Region: AAA_19; pfam13245 508765007859 Family description; Region: UvrD_C_2; pfam13538 508765007860 nicotinate phosphoribosyltransferase; Validated; Region: PRK09243 508765007861 Nicotinate phosphoribosyltransferase (NAPRTase), subgroup A. Nicotinate phosphoribosyltransferase catalyses the formation of NAMN and PPi from 5-phosphoribosy -1-pyrophosphate (PRPP) and nicotinic acid, this is the first, and also rate limiting, reaction...; Region: NAPRTase_A; cd01570 508765007862 active site 508765007863 Ferric uptake regulator(Fur) and related metalloregulatory proteins; typically iron-dependent, DNA-binding repressors and activators; Region: Fur_like; cd07153 508765007864 metal binding site 2 [ion binding]; metal-binding site 508765007865 putative DNA binding helix; other site 508765007866 metal binding site 1 [ion binding]; metal-binding site 508765007867 dimer interface [polypeptide binding]; other site 508765007868 structural Zn2+ binding site [ion binding]; other site 508765007869 YihA (EngB) GTPase family; Region: YihA_EngB; cd01876 508765007870 G1 box; other site 508765007871 GTP/Mg2+ binding site [chemical binding]; other site 508765007872 Switch I region; other site 508765007873 G2 box; other site 508765007874 G3 box; other site 508765007875 Switch II region; other site 508765007876 G4 box; other site 508765007877 G5 box; other site 508765007878 ATP-dependent Lon protease, bacterial type [Posttranslational modification, protein turnover, chaperones]; Region: Lon; COG0466 508765007879 Found in ATP-dependent protease La (LON); Region: LON; smart00464 508765007880 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 508765007881 Walker A motif; other site 508765007882 ATP binding site [chemical binding]; other site 508765007883 Walker B motif; other site 508765007884 arginine finger; other site 508765007885 Lon protease (S16) C-terminal proteolytic domain; Region: Lon_C; pfam05362 508765007886 ATP-dependent protease ATP-binding subunit ClpX; Provisional; Region: clpX; PRK05342 508765007887 ClpX C4-type zinc finger; Region: zf-C4_ClpX; pfam06689 508765007888 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 508765007889 Walker A motif; other site 508765007890 ATP binding site [chemical binding]; other site 508765007891 Walker B motif; other site 508765007892 C-terminal, D2-small domain, of ClpB protein; Region: ClpB_D2-small; smart01086 508765007893 Protease subunit of ATP-dependent Clp proteases [Posttranslational modification, protein turnover, chaperones / Intracellular trafficking and secretion]; Region: ClpP; COG0740 508765007894 Caseinolytic protease (ClpP) is an ATP-dependent, highly conserved serine protease; Region: S14_ClpP_2; cd07017 508765007895 oligomer interface [polypeptide binding]; other site 508765007896 active site residues [active] 508765007897 trigger factor; Provisional; Region: tig; PRK01490 508765007898 FKBP-type peptidyl-prolyl cis-trans isomerase; Region: FKBP_C; pfam00254 508765007899 Bacterial trigger factor protein (TF) C-terminus; Region: Trigger_C; pfam05698 508765007900 histidinol-phosphatase; Provisional; Region: PRK05588 508765007901 Polymerase and Histidinol Phosphatase domain; Region: PHP; cl17102 508765007902 active site 508765007903 Acetyltransferase (GNAT) domain; Region: Acetyltransf_3; pfam13302 508765007904 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 508765007905 Coenzyme A binding pocket [chemical binding]; other site 508765007906 EDD domain protein, DegV family; Region: DegV; TIGR00762 508765007907 Uncharacterized protein, DegV family COG1307; Region: DegV; pfam02645 508765007908 hypothetical protein; Provisional; Region: PRK04435 508765007909 C-terminal ACT domain of a small (; 147 a.a.) putative phenylalanine biosynthetic pathway protein described in Bacillus subtilis (BS) PheB (PheB-BS) and related domains; Region: ACT_PheB-BS; cd04888 508765007910 homoserine kinase; Provisional; Region: PRK01212 508765007911 GHMP kinases N terminal domain; Region: GHMP_kinases_N; pfam00288 508765007912 GHMP kinases C terminal; Region: GHMP_kinases_C; pfam08544 508765007913 Threonine synthase [Amino acid transport and metabolism]; Region: ThrC; COG0498 508765007914 Threonine synthase catalyzes the final step of threonine biosynthesis. The conversion of O-phosphohomoserine into threonine and inorganic phosphate is pyridoxal 5'-phosphate dependent. The Thr-synth_1 CD includes members from higher plants; Region: Thr-synth_2; cd01560 508765007915 pyridoxal 5'-phosphate binding site [chemical binding]; other site 508765007916 catalytic residue [active] 508765007917 Esterases and lipases (includes fungal lipases, cholinesterases, etc.) These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cd00312 508765007918 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 508765007919 Ion channel; Region: Ion_trans_2; pfam07885 508765007920 Protein of unknown function (DUF3867); Region: DUF3867; pfam12983 508765007921 Cobalt chelatase (CbiK); Region: CbiK; pfam06180 508765007922 Class II Chelatase: a family of ATP-independent monomeric or homodimeric enzymes that catalyze the insertion of metal into protoporphyrin rings. This family includes protoporphyrin IX ferrochelatase (HemH), sirohydrochlorin ferrochelatase (SirB) and the...; Region: Chelatase_Class_II; cl02784 508765007923 active site 508765007924 Class II Chelatase: a family of ATP-independent monomeric or homodimeric enzymes that catalyze the insertion of metal into protoporphyrin rings. This family includes protoporphyrin IX ferrochelatase (HemH), sirohydrochlorin ferrochelatase (SirB) and the...; Region: Chelatase_Class_II; cl02784 508765007925 active site 508765007926 glutamate-1-semialdehyde aminotransferase; Provisional; Region: PRK00062 508765007927 Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610 508765007928 inhibitor-cofactor binding pocket; inhibition site 508765007929 pyridoxal 5'-phosphate binding site [chemical binding]; other site 508765007930 catalytic residue [active] 508765007931 Porphobilinogen synthase (PBGS), which is also called delta-aminolevulinic acid dehydratase (ALAD), catalyzes the condensation of two 5-aminolevulinic acid (ALA) molecules to form the pyrrole porphobilinogen (PBG), which is the second step in the...; Region: ALAD_PBGS; cd00384 508765007932 dimer interface [polypeptide binding]; other site 508765007933 active site 508765007934 Schiff base residues; other site 508765007935 Uroporphyrin-III C-methyltransferase (S-Adenosyl-L-methionine:uroporphyrinogen III methyltransferase, SUMT); Region: SUMT; cd11642 508765007936 Diphthamide biosynthesis methyltransferase [Translation, ribosomal structure and biogenesis]; Region: DPH5; COG1798 508765007937 active site 508765007938 SAM binding site [chemical binding]; other site 508765007939 homodimer interface [polypeptide binding]; other site 508765007940 Uroporphyrinogen-III synthase [Coenzyme metabolism]; Region: HemD; COG1587 508765007941 Uroporphyrinogen-III synthase (HemD) catalyzes the asymmetrical cyclization of tetrapyrrole (linear) to uroporphyrinogen-III, the fourth step in the biosynthesis of heme. This ubiquitous enzyme is present in eukaryotes, bacteria and archaea. Mutations in...; Region: HemD; cd06578 508765007942 active site 508765007943 porphobilinogen deaminase; Reviewed; Region: hemC; PRK00072 508765007944 Hydroxymethylbilane synthase (HMBS), also known as porphobilinogen deaminase (PBGD), is an intermediate enzyme in the biosynthetic pathway of tetrapyrrolic ring systems, such as heme, chlorophylls, and vitamin B12. HMBS catalyzes the conversion of...; Region: HMBS; cd00494 508765007945 domain interfaces; other site 508765007946 active site 508765007947 precorrin-2 dehydrogenase; Provisional; Region: PRK05562 508765007948 Putative NAD(P)-binding; Region: NAD_binding_7; pfam13241 508765007949 glutamyl-tRNA reductase; Reviewed; Region: hemA; PRK00045 508765007950 NADP-binding domain of glutamyl-tRNA reductase; Region: NAD_bind_Glutamyl_tRNA_reduct; cd05213 508765007951 tRNA; other site 508765007952 putative tRNA binding site [nucleotide binding]; other site 508765007953 putative NADP binding site [chemical binding]; other site 508765007954 sulfite reductase, subunit C; Region: sulfite_red_C; TIGR02912 508765007955 Nitrite/Sulfite reductase ferredoxin-like half domain; Region: NIR_SIR_ferr; pfam03460 508765007956 RPB11 and RPB3 subunits of RNA polymerase; Region: RNAP_RPB11_RPB3; cl11409 508765007957 Undecaprenyl pyrophosphate synthase [Lipid metabolism]; Region: UppS; COG0020 508765007958 Cis (Z)-Isoprenyl Diphosphate Synthases (cis-IPPS); homodimers which catalyze the successive 1'-4 condensation of the isopentenyl diphosphate (IPP) molecule to trans,trans-farnesyl diphosphate (FPP) or to cis,trans-FPP to form long-chain polyprenyl...; Region: CIS_IPPS; cl00230 508765007959 catalytic residue [active] 508765007960 putative FPP diphosphate binding site; other site 508765007961 putative FPP binding hydrophobic cleft; other site 508765007962 dimer interface [polypeptide binding]; other site 508765007963 putative IPP diphosphate binding site; other site 508765007964 solute carrier 6 subfamily, Fusobacterium nucleatum Tyt1-like; solute-binding domain; Region: SLC6sbd_Tyt1-Like; cd10336 508765007965 Na2 binding site [ion binding]; other site 508765007966 putative substrate binding site 1 [chemical binding]; other site 508765007967 Na binding site 1 [ion binding]; other site 508765007968 putative substrate binding site 2 [chemical binding]; other site 508765007969 homoserine O-succinyltransferase; Provisional; Region: PRK05368 508765007970 Type 1 glutamine amidotransferase (GATase1)-like domain found in homoserine trans-succinylase (HTS); Region: GATase1_HTS; cd03131 508765007971 proposed active site lysine [active] 508765007972 conserved cys residue [active] 508765007973 Lactonase, 7-bladed beta-propeller; Region: Lactonase; pfam10282 508765007974 sugar phosphate phosphatase; Provisional; Region: PRK10513 508765007975 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 508765007976 active site 508765007977 motif I; other site 508765007978 motif II; other site 508765007979 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 508765007980 putative sporulation protein YtaF; Region: spore_YtaF; TIGR02840 508765007981 Domain of unknown function DUF; Region: DUF204; pfam02659 508765007982 cobyric acid synthase; Provisional; Region: PRK00784 508765007983 Dethiobiotin synthetase [Coenzyme metabolism]; Region: BioD; COG0132 508765007984 Type 1 glutamine amidotransferase (GATase1) domain found in Cobyric Acid Synthase (CobQ); Region: GATase1_CobQ; cd01750 508765007985 catalytic triad [active] 508765007986 threonine-phosphate decarboxylase; Provisional; Region: PRK06358 508765007987 Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321 508765007988 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 508765007989 pyridoxal 5'-phosphate binding site [chemical binding]; other site 508765007990 homodimer interface [polypeptide binding]; other site 508765007991 catalytic residue [active] 508765007992 cobalamin biosynthesis protein; Provisional; Region: cobD; PRK01209 508765007993 Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067 508765007994 catalytic core [active] 508765007995 Cobinamide kinase / cobinamide phosphate guanyltransferase; Region: CobU; cl17363 508765007996 cobalamin synthase; Reviewed; Region: cobS; PRK00235 508765007997 RecA-like NTPases. This family includes the NTP binding domain of F1 and V1 H+ATPases, DnaB and related helicases as well as bacterial RecA and related eukaryotic and archaeal recombinases. This group also includes bacterial conjugation proteins and...; Region: RecA-like_NTPases; cl17233 508765007998 ATP binding site [chemical binding]; other site 508765007999 Walker B motif; other site 508765008000 ATP:corrinoid adenosyltransferase BtuR/CobO/CobP; Region: CobA_CobO_BtuR; cl17276 508765008001 ABC-type nitrate/sulfonate/bicarbonate transport system, permease component [Inorganic ion transport and metabolism]; Region: TauC; COG0600 508765008002 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 508765008003 dimer interface [polypeptide binding]; other site 508765008004 conserved gate region; other site 508765008005 putative PBP binding loops; other site 508765008006 ABC-ATPase subunit interface; other site 508765008007 Periplasmic glycine betaine/choline-binding (lipo)protein of an ABC-type transport system (osmoprotectant binding protein) [Cell envelope biogenesis, outer membrane]; Region: OpuBC; COG1732 508765008008 ABC-type proline/glycine betaine transport systems, periplasmic components [Amino acid transport and metabolism]; Region: ProX; cl17891 508765008009 ABC-type proline/glycine betaine transport systems, ATPase components [Amino acid transport and metabolism]; Region: OpuBA; COG1125 508765008010 ATP-binding cassette domain of the osmoprotectant transporter; Region: ABC_OpuCA_Osmoprotection; cd03295 508765008011 Walker A/P-loop; other site 508765008012 ATP binding site [chemical binding]; other site 508765008013 Q-loop/lid; other site 508765008014 ABC transporter signature motif; other site 508765008015 Walker B; other site 508765008016 D-loop; other site 508765008017 H-loop/switch region; other site 508765008018 FOG: CBS domain [General function prediction only]; Region: COG0517 508765008019 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains in association with the ABC transporter OpuCA. OpuCA is the ATP binding component of a bacterial solute transporter that serves a protective role to cells growing...; Region: CBS_pair_ABC_OpuCA_assoc2; cd04583 508765008020 Transcriptional regulators [Transcription]; Region: PhnF; COG2188 508765008021 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 508765008022 DNA-binding site [nucleotide binding]; DNA binding site 508765008023 TrkA-C domain; Region: TrkA_C; pfam02080 508765008024 Phosphoribosyltransferase; Region: DBI_PRT; pfam02277 508765008025 Nicotinate-nucleotide-dimethylbenzimidazole phosphoribosyltransferase (DMB-PRT), also called CobT; Region: DMB-PRT_CobT; cd02439 508765008026 putative dimer interface [polypeptide binding]; other site 508765008027 active site pocket [active] 508765008028 putative cataytic base [active] 508765008029 cobalt-precorrin-6x reductase; Reviewed; Region: PRK08057 508765008030 Precorrin-6x reductase [Coenzyme metabolism]; Region: CobK; COG2099 508765008031 Precorrin-3B C(17)-methyltransferase (CobJ/CbiH); Region: Precorrin_3B_C17_MT; cd11646 508765008032 active site 508765008033 SAM binding site [chemical binding]; other site 508765008034 homodimer interface [polypeptide binding]; other site 508765008035 cobalamin biosynthesis protein CbiG; Validated; Region: PRK05788 508765008036 Cobalamin synthesis G N-terminal; Region: CbiG_N; pfam11760 508765008037 Cobalamin biosynthesis central region; Region: CbiG_mid; pfam11761 508765008038 Cobalamin synthesis G C-terminus; Region: CbiG_C; pfam01890 508765008039 Precorrin-4 C11-methyltransferase (CbiF/CobM); Region: Precorrin-4_C11-MT; cd11641 508765008040 active site 508765008041 SAM binding site [chemical binding]; other site 508765008042 homodimer interface [polypeptide binding]; other site 508765008043 Precorrin-2 C20-methyltransferase, also named CobI or CbiL; Region: Precorrin_2_C20_MT; cd11645 508765008044 active site 508765008045 SAM binding site [chemical binding]; other site 508765008046 homodimer interface [polypeptide binding]; other site 508765008047 Precorrin-6B methylase 2 [Coenzyme metabolism]; Region: CobL; COG2242 508765008048 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl17173 508765008049 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 508765008050 S-adenosylmethionine binding site [chemical binding]; other site 508765008051 Precorrin-6Y methyltransferase, the cobalamin biosynthesis enzyme CbiE; Region: Precorrin-6Y-methylase; cd11644 508765008052 active site 508765008053 putative homodimer interface [polypeptide binding]; other site 508765008054 SAM binding site [chemical binding]; other site 508765008055 cobalt-precorrin-6A synthase; Reviewed; Region: cbiD; PRK00075 508765008056 precorrin-8X methylmutase; Validated; Region: cbiC; PRK05575 508765008057 cobalt-precorrin-8X methylmutase; Validated; Region: cbiC; cl00913 508765008058 cobyrinic acid a,c-diamide synthase; Validated; Region: PRK01077 508765008059 Type 1 glutamine amidotransferase (GATase1) domain found in Cobyrinic Acid a,c-Diamide Synthase; Region: GATase1_CobB; cd03130 508765008060 catalytic triad [active] 508765008061 Cobalt chelatase (CbiK); Region: CbiK; pfam06180 508765008062 Anaerobic cobalamin biosynthetic cobalt chelatase (CbiK), N-terminal domain. CbiK is part of the cobalt-early path for cobalamin biosynthesis. It catalyzes the insertion of cobalt into the oxidized form of precorrin-2, factor II (sirohydrochlorin), the...; Region: CbiK_N; cd03412 508765008063 active site 508765008064 C-terminal domain interface [polypeptide binding]; other site 508765008065 Anaerobic cobalamin biosynthetic cobalt chelatase (CbiK), C-terminal domain. CbiK is part of the cobalt-early path for cobalamin biosynthesis. It catalyzes the insertion of cobalt into the oxidized form of precorrin-2, factor II (sirohydrochlorin), the...; Region: CbiK_C; cd03413 508765008066 active site 508765008067 N-terminal domain interface [polypeptide binding]; other site 508765008068 solute carrier 6 subfamily, Fusobacterium nucleatum Tyt1-like; solute-binding domain; Region: SLC6sbd_Tyt1-Like; cd10336 508765008069 Na2 binding site [ion binding]; other site 508765008070 putative substrate binding site 1 [chemical binding]; other site 508765008071 Na binding site 1 [ion binding]; other site 508765008072 putative substrate binding site 2 [chemical binding]; other site 508765008073 Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596 508765008074 Multimeric flavodoxin WrbA [General function prediction only]; Region: WrbA; COG0655 508765008075 NADPH-dependent FMN reductase; Region: FMN_red; pfam03358 508765008076 Alcohol dehydrogenase, class IV [Energy production and conversion]; Region: EutG; COG1454 508765008077 Iron-containing alcohol dehydrogenases-like; Region: Fe-ADH1; cd08185 508765008078 putative active site [active] 508765008079 metal binding site [ion binding]; metal-binding site 508765008080 Xanthine/uracil permeases [Nucleotide transport and metabolism]; Region: UraA; COG2233 508765008081 PyrR binding site 508765008082 lysozyme_like domain. This contains several members including Soluble Lytic Transglycosylases (SLT), Goose Egg-White Lysozymes (GEWL), Hen Egg-White Lysozymes (HEWL), chitinases, bacteriophage lambda lysozymes, endolysins, autolysins, and chitosanases; Region: lysozyme_like; cl00222 508765008083 catalytic residue [active] 508765008084 Metal-dependent hydrolases of the beta-lactamase superfamily II [General function prediction only]; Region: COG1237 508765008085 Methyl-accepting chemotaxis protein [Cell motility and secretion / Signal transduction mechanisms]; Region: Tar; COG0840 508765008086 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 508765008087 dimer interface [polypeptide binding]; other site 508765008088 putative CheW interface [polypeptide binding]; other site 508765008089 ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132 508765008090 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 508765008091 ATP-binding cassette domain of glucan transporter and related proteins, subfamily C; Region: ABCC_Glucan_exporter_like; cd03254 508765008092 Walker A/P-loop; other site 508765008093 ATP binding site [chemical binding]; other site 508765008094 Q-loop/lid; other site 508765008095 ABC transporter signature motif; other site 508765008096 Walker B; other site 508765008097 D-loop; other site 508765008098 H-loop/switch region; other site 508765008099 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 508765008100 ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132 508765008101 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 508765008102 Walker A/P-loop; other site 508765008103 ATP binding site [chemical binding]; other site 508765008104 Q-loop/lid; other site 508765008105 ABC transporter signature motif; other site 508765008106 Walker B; other site 508765008107 D-loop; other site 508765008108 H-loop/switch region; other site 508765008109 MarR family; Region: MarR_2; pfam12802 508765008110 ribulokinase; Provisional; Region: PRK04123 508765008111 Ribulokinases; belongs to the FGGY family of carbohydrate kinases; Region: FGGY_RBK; cd07781 508765008112 N- and C-terminal domain interface [polypeptide binding]; other site 508765008113 active site 508765008114 MgATP binding site [chemical binding]; other site 508765008115 catalytic site [active] 508765008116 metal binding site [ion binding]; metal-binding site 508765008117 carbohydrate binding site [chemical binding]; other site 508765008118 homodimer interface [polypeptide binding]; other site 508765008119 Glycerol-1-phosphate dehydrogenase (G1PDH) catalyzes the reversible reduction of dihydroxyacetone phosphate (DHAP) to glycerol-1-phosphate (G1P) in an NADH-dependent manner; Region: G1PDH; cd08175 508765008120 active site 508765008121 metal binding site [ion binding]; metal-binding site 508765008122 Predicted sugar phosphatases of the HAD superfamily [Carbohydrate transport and metabolism]; Region: NagD; COG0647 508765008123 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 508765008124 active site 508765008125 motif I; other site 508765008126 motif II; other site 508765008127 HAD-hyrolase-like; Region: Hydrolase_like; pfam13242 508765008128 Transcriptional regulators [Transcription]; Region: PurR; COG1609 508765008129 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 508765008130 DNA binding site [nucleotide binding] 508765008131 domain linker motif; other site 508765008132 Ligand binding domain of the LacI tanscriptional regulator family belonging to the type I periplasmic-binding fold protein superfamily; Region: PBP1_LacI_sugar_binding_like; cd06267 508765008133 dimerization interface [polypeptide binding]; other site 508765008134 ligand binding site [chemical binding]; other site 508765008135 zinc transporter ZupT; Provisional; Region: PRK04201 508765008136 ZIP Zinc transporter; Region: Zip; pfam02535 508765008137 Galactose-1-phosphate uridylyltransferase [Energy production and conversion]; Region: GalT; COG1085 508765008138 HIT family: HIT (Histidine triad) proteins, named for a motif related to the sequence HxHxH/Qxx (x, a hydrophobic amino acid), are a superfamily of nucleotide hydrolases and transferases, which act on the alpha-phosphate of ribonucleotides. On the basis...; Region: HIT_like; cl00228 508765008139 nucleotide binding site/active site [active] 508765008140 HIT family signature motif; other site 508765008141 catalytic residue [active] 508765008142 Predicted secreted protein [Function unknown]; Region: COG4086 508765008143 Protein of unknown function (DUF1002); Region: DUF1002; pfam06207 508765008144 Nitrite/Sulfite reductase ferredoxin-like half domain; Region: NIR_SIR_ferr; pfam03460 508765008145 Nitrite and sulphite reductase 4Fe-4S domain; Region: NIR_SIR; pfam01077 508765008146 Arsenate Reductase (ArsC) family, unknown subfamily; uncharacterized proteins containing a CXXC motif with similarity to thioredoxin (TRX)-fold arsenic reductases, ArsC. Proteins containing a redox active CXXC motif like TRX and glutaredoxin (GRX)...; Region: ArsC_like; cd03036 508765008147 ArsC family; Region: ArsC; pfam03960 508765008148 putative ArsC-like catalytic residues; other site 508765008149 putative TRX-like catalytic residues [active] 508765008150 ECF-type riboflavin transporter, S component; Region: ECF-ribofla_trS; cl17272 508765008151 Protein of unknown function (DUF3816); Region: DUF3816; pfam12822 508765008152 c-di-GMP phosphodiesterase class II (HD-GYP domain) [Signal transduction mechanisms]; Region: COG2206 508765008153 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 508765008154 Zn2+ binding site [ion binding]; other site 508765008155 Mg2+ binding site [ion binding]; other site 508765008156 Domain of unknown function (DUF368); Region: DUF368; pfam04018 508765008157 EDD domain protein, DegV family; Region: DegV; TIGR00762 508765008158 Uncharacterized protein, DegV family COG1307; Region: DegV; pfam02645 508765008159 purine nucleoside phosphorylase; Reviewed; Region: deoD; PRK05819 508765008160 Uridine phosphorylase [Nucleotide transport and metabolism]; Region: Udp; COG2820 508765008161 Cytidine deaminase zinc-binding domain. These enzymes are Zn dependent. The zinc ion in the active site plays a central role in the proposed catalytic mechanism, activating a water molecule to form a hydroxide ion that performs a nucleophilic attack on...; Region: cytidine_deaminase; cd01283 508765008162 active site 508765008163 catalytic motif [active] 508765008164 Zn binding site [ion binding]; other site 508765008165 Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653 508765008166 Transmembrane subunit (TM) of Treponema pallidum (Tp) RbsC-1, RbsC-2 and related proteins. This is a functionally uncharacterized subgroup of TMs which belong to a larger group of TMs of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette; Region: TM_PBP1_transp_TpRbsC_like; cd06580 508765008167 TM-ABC transporter signature motif; other site 508765008168 Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653 508765008169 Transmembrane subunit (TM) of Treponema pallidum (Tp) RbsC-1, RbsC-2 and related proteins. This is a functionally uncharacterized subgroup of TMs which belong to a larger group of TMs of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette; Region: TM_PBP1_transp_TpRbsC_like; cd06580 508765008170 TM-ABC transporter signature motif; other site 508765008171 ABC-type uncharacterized transport systems, ATPase components [General function prediction only]; Region: COG3845 508765008172 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 508765008173 Walker A/P-loop; other site 508765008174 ATP binding site [chemical binding]; other site 508765008175 Q-loop/lid; other site 508765008176 ABC transporter signature motif; other site 508765008177 Walker B; other site 508765008178 D-loop; other site 508765008179 H-loop/switch region; other site 508765008180 Second domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_II; cd03215 508765008181 Uncharacterized ABC-type transport system, periplasmic component/surface lipoprotein [General function prediction only]; Region: Med; COG1744 508765008182 Periplasmic binding domain of basic membrane lipoprotein, PnrA, in Treponema pallidum and its homologs from other bacteria and Archaea; Region: PBP1_BmpA_PnrA_like; cd06354 508765008183 ligand binding site [chemical binding]; other site 508765008184 Transcriptional regulators [Transcription]; Region: PurR; COG1609 508765008185 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 508765008186 DNA binding site [nucleotide binding] 508765008187 domain linker motif; other site 508765008188 Ligand binding domain of the LacI tanscriptional regulator family belonging to the type I periplasmic-binding fold protein superfamily; Region: PBP1_LacI_sugar_binding_like; cd06267 508765008189 dimerization interface [polypeptide binding]; other site 508765008190 ligand binding site [chemical binding]; other site 508765008191 hypothetical protein; Validated; Region: PRK07682 508765008192 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 508765008193 pyridoxal 5'-phosphate binding site [chemical binding]; other site 508765008194 homodimer interface [polypeptide binding]; other site 508765008195 catalytic residue [active] 508765008196 Transcriptional regulators [Transcription]; Region: Lrp; COG1522 508765008197 AsnC family; Region: AsnC_trans_reg; pfam01037 508765008198 T-box leader 508765008199 pullulanase, type I; Region: pulA_typeI; TIGR02104 508765008200 Early set domain associated with the catalytic domain of pullulanase (also called dextrinase and alpha-dextrin endo-1,6-alpha glucosidase); Region: E_set_Pullulanase; cd02860 508765008201 Alpha amylase catalytic domain found in Pullulanase (also called dextrinase; alpha-dextrin endo-1,6-alpha glucosidase), limit dextrinase, and related proteins; Region: AmyAc_Pullulanase_LD-like; cd11341 508765008202 Ca binding site [ion binding]; other site 508765008203 active site 508765008204 catalytic site [active] 508765008205 uncharacterized bacterial and archaeal solute carrier 6 subfamily; solute-binding domain; Region: SLC6sbd_u1; cd10334 508765008206 Na2 binding site [ion binding]; other site 508765008207 putative substrate binding site 1 [chemical binding]; other site 508765008208 Na binding site 1 [ion binding]; other site 508765008209 putative substrate binding site 2 [chemical binding]; other site 508765008210 Arginine/lysine/ornithine decarboxylases [Amino acid transport and metabolism]; Region: LdcC; COG1982 508765008211 Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321 508765008212 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 508765008213 catalytic residue [active] 508765008214 Orn/Lys/Arg decarboxylase, C-terminal domain; Region: OKR_DC_1_C; pfam03711 508765008215 Predicted Zn-dependent peptidases [General function prediction only]; Region: PqqL; COG0612 508765008216 Insulinase (Peptidase family M16); Region: Peptidase_M16; pfam00675 508765008217 Peptidase M16 inactive domain; Region: Peptidase_M16_C; pfam05193 508765008218 ATPase components of ABC transporters with duplicated ATPase domains [General function prediction only]; Region: Uup; COG0488 508765008219 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 508765008220 Walker A/P-loop; other site 508765008221 ATP binding site [chemical binding]; other site 508765008222 Q-loop/lid; other site 508765008223 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 508765008224 ABC transporter; Region: ABC_tran_2; pfam12848 508765008225 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 508765008226 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 508765008227 dimer interface [polypeptide binding]; other site 508765008228 putative CheW interface [polypeptide binding]; other site 508765008229 SCIFF radical SAM maturase; Region: rSAM_six_Cys; TIGR03974 508765008230 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 508765008231 FeS/SAM binding site; other site 508765008232 radical SAM additional 4Fe4S-binding SPASM domain; Region: rSAM_more_4Fe4S; TIGR04085 508765008233 Protein of unknown function (DUF4001); Region: DUF4001; cl14848 508765008234 heat shock protein 90; Provisional; Region: PRK05218 508765008235 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 508765008236 ATP binding site [chemical binding]; other site 508765008237 Mg2+ binding site [ion binding]; other site 508765008238 G-X-G motif; other site 508765008239 Type 1 periplasmic binding fold superfamily; Region: Periplasmic_Binding_Protein_Type_1; cl10011 508765008240 maltose O-acetyltransferase; Provisional; Region: PRK10092 508765008241 Maltose O-acetyltransferase (MAT) and Galactoside O-acetyltransferase (GAT): MAT and GAT catalyze the CoA-dependent acetylation of the 6-hydroxyl group of their respective sugar substrates. MAT acetylates maltose and glucose exclusively at the C6...; Region: LbH_MAT_GAT; cd03357 508765008242 active site 508765008243 substrate binding site [chemical binding]; other site 508765008244 trimer interface [polypeptide binding]; other site 508765008245 CoA binding site [chemical binding]; other site 508765008246 ATP-binding cassette domain of sbcCD; Region: ABC_sbcCD; cd03279 508765008247 AAA domain; Region: AAA_23; pfam13476 508765008248 Walker A/P-loop; other site 508765008249 ATP binding site [chemical binding]; other site 508765008250 Q-loop/lid; other site 508765008251 ATPase involved in DNA repair [DNA replication, recombination, and repair]; Region: SbcC; COG0419 508765008252 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 508765008253 ABC transporter signature motif; other site 508765008254 Walker B; other site 508765008255 D-loop; other site 508765008256 H-loop/switch region; other site 508765008257 DNA repair exonuclease [DNA replication, recombination, and repair]; Region: SbcD; COG0420 508765008258 Mre11 nuclease, N-terminal metallophosphatase domain; Region: MPP_Mre11_N; cd00840 508765008259 active site 508765008260 metal binding site [ion binding]; metal-binding site 508765008261 DNA binding site [nucleotide binding] 508765008262 Type 5 capsule protein repressor C-terminal domain; Region: SbcD_C; pfam12320 508765008263 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl17182 508765008264 Uncharacterized conserved protein [Function unknown]; Region: COG1434 508765008265 YdcF-like. YdcF-like is a large family of mainly bacterial proteins, with a few members found in fungi, plants, and archaea. Escherichia coli YdcF has been shown to bind S-adenosyl-L-methionine (AdoMet), but a biochemical function has not been...; Region: YdcF-like; cd06259 508765008266 putative active site [active] 508765008267 stationary phase survival protein SurE; Provisional; Region: PRK13933 508765008268 Beta-lactamase class C and other penicillin binding proteins [Defense mechanisms]; Region: AmpC; COG1680 508765008269 Beta-lactamase; Region: Beta-lactamase; pfam00144 508765008270 Four helix bundle sensory module for signal transduction; Region: 4HB_MCP_1; pfam12729 508765008271 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 508765008272 dimerization interface [polypeptide binding]; other site 508765008273 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 508765008274 dimer interface [polypeptide binding]; other site 508765008275 putative CheW interface [polypeptide binding]; other site 508765008276 Predicted hydrolases of the HAD superfamily [General function prediction only]; Region: Cof; COG0561 508765008277 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 508765008278 active site 508765008279 motif I; other site 508765008280 motif II; other site 508765008281 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 508765008282 Transcriptional regulators of sugar metabolism [Transcription / Carbohydrate transport and metabolism]; Region: GlpR; COG1349 508765008283 helix_turn_helix, Deoxyribose operon repressor; Region: HTH_DEOR; smart00420 508765008284 DeoR C terminal sensor domain; Region: DeoRC; pfam00455 508765008285 diaminopimelate dehydrogenase; Region: DAP-DH; TIGR01921 508765008286 Dihydrodipicolinate reductase, N-terminus; Region: DapB_N; pfam01113 508765008287 putative kinase; Provisional; Region: PRK09954 508765008288 Winged helix-turn-helix DNA-binding; Region: HTH_24; pfam13412 508765008289 putative DNA binding site [nucleotide binding]; other site 508765008290 putative Zn2+ binding site [ion binding]; other site 508765008291 YeiC-like sugar kinase. Found in eukaryotes and bacteria, YeiC-like kinase is part of the ribokinase/pfkB sugar kinase superfamily. Its oligomerization state is unknown at this time; Region: YeiC_kinase_like; cd01941 508765008292 substrate binding site [chemical binding]; other site 508765008293 ATP binding site [chemical binding]; other site 508765008294 Alcohol dehydrogenase, class IV [Energy production and conversion]; Region: EutG; COG1454 508765008295 Dehydroquinate synthase-like (DHQ-like) and iron-containing alcohol dehydrogenases (Fe-ADH); Region: DHQ_Fe-ADH; cl02872 508765008296 active site 508765008297 NAD binding site [chemical binding]; other site 508765008298 metal binding site [ion binding]; metal-binding site 508765008299 Phosphoribosylanthranilate isomerase (PRAI) catalyzes the fourth step of the tryptophan biosynthesis, the conversion of N-(5'- phosphoribosyl)-anthranilate (PRA) to 1-(o-carboxyphenylamino)- 1-deoxyribulose 5-phosphate (CdRP). Most PRAIs are...; Region: PRAI; cd00405 508765008300 active site 508765008301 YeiC-like sugar kinase. Found in eukaryotes and bacteria, YeiC-like kinase is part of the ribokinase/pfkB sugar kinase superfamily. Its oligomerization state is unknown at this time; Region: YeiC_kinase_like; cd01941 508765008302 Sugar kinases, ribokinase family [Carbohydrate transport and metabolism]; Region: RbsK; COG0524 508765008303 substrate binding site [chemical binding]; other site 508765008304 ATP binding site [chemical binding]; other site 508765008305 RNA polymerase sigma factor RpoE; Provisional; Region: PRK09652 508765008306 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 508765008307 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 508765008308 DNA binding residues [nucleotide binding] 508765008309 Predicted phosphatases [General function prediction only]; Region: Gph; COG0546 508765008310 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 508765008311 active site 508765008312 motif I; other site 508765008313 motif II; other site 508765008314 helix_turn_helix, cAMP Regulatory protein C-terminus; DNA binding domain of prokaryotic regulatory proteins belonging to the catabolite activator protein family; Region: HTH_CRP; cl17320 508765008315 non-specific DNA interactions [nucleotide binding]; other site 508765008316 DNA binding site [nucleotide binding] 508765008317 sequence specific DNA binding site [nucleotide binding]; other site 508765008318 putative cAMP binding site [chemical binding]; other site 508765008319 Transcriptional regulator/sugar kinase [Transcription / Carbohydrate transport and metabolism]; Region: NagC; COG1940 508765008320 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cl17037 508765008321 Predicted membrane protein involved in D-alanine export [Cell envelope biogenesis, outer membrane]; Region: DltB; COG1696 508765008322 Peptidase Gluzincin family (thermolysin-like proteinases, TLPs) includes peptidases M1, M2, M3, M4, M13, M32 and M36 (fungalysins); Region: GluZincin; cl14813 508765008323 Zn binding site [ion binding]; other site 508765008324 ABC-type multidrug transport system, ATPase component [Defense mechanisms]; Region: CcmA; COG1131 508765008325 ABC-type multidrug transport system, ATPase component; Region: ABC_drug_resistance_like; cd03264 508765008326 Walker A/P-loop; other site 508765008327 ATP binding site [chemical binding]; other site 508765008328 Q-loop/lid; other site 508765008329 ABC transporter signature motif; other site 508765008330 Walker B; other site 508765008331 D-loop; other site 508765008332 H-loop/switch region; other site 508765008333 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 508765008334 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 508765008335 dimerization interface [polypeptide binding]; other site 508765008336 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 508765008337 dimer interface [polypeptide binding]; other site 508765008338 phosphorylation site [posttranslational modification] 508765008339 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 508765008340 ATP binding site [chemical binding]; other site 508765008341 Mg2+ binding site [ion binding]; other site 508765008342 G-X-G motif; other site 508765008343 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 508765008344 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 508765008345 active site 508765008346 phosphorylation site [posttranslational modification] 508765008347 intermolecular recognition site; other site 508765008348 dimerization interface [polypeptide binding]; other site 508765008349 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 508765008350 DNA binding site [nucleotide binding] 508765008351 Endonuclease I; Region: Endonuclease_1; pfam04231 508765008352 Phosphotransferase system, EIIC; Region: PTS_EIIC_2; pfam13303 508765008353 Phosphotransferase system, fructose-specific IIC component [Carbohydrate transport and metabolism]; Region: FruA; cl17425 508765008354 Elongator protein 3, MiaB family, Radical SAM; Region: Elp3; smart00729 508765008355 Protein of unknown function (DUF3816); Region: DUF3816; pfam12822 508765008356 NH_3: A subgroup of nucleoside hydrolases. This group contains eukaryotic and bacterial proteins similar to nucleoside hydrolases. Nucleoside hydrolases cleave the N-glycosidic bond in nucleosides generating ribose and the respective base. These enzymes...; Region: nuc_hydro_3; cd02653 508765008357 active site 508765008358 PreQ1 riboswitch 508765008359 EamA-like transporter family; Region: EamA; cl17759 508765008360 Rubredoxin, Small Modular nonheme iron binding domain containing a [Fe(SCys)4] center, present in rubrerythrin and nigerythrin and detected either N- or C-terminal to such proteins as flavin reductase, NAD(P)H-nitrite reductase, and...; Region: rubredoxin_SM; cd00729 508765008361 Rubredoxin; Region: Rubredoxin; pfam00301 508765008362 iron binding site [ion binding]; other site 508765008363 Rubrerythrin [Energy production and conversion]; Region: COG1592 508765008364 rubrerythrin-like, diiron-binding domain; Region: Rubrerythrin_like; cd01046 508765008365 diiron binding motif [ion binding]; other site 508765008366 Domain of Unknown Function (DUF1540); Region: DUF1540; pfam07561 508765008367 Domain of Unknown Function (DUF1540); Region: DUF1540; pfam07561 508765008368 Fe2+ transport system protein B [Inorganic ion transport and metabolism]; Region: FeoB; COG0370 508765008369 Ferrous iron transport protein B (FeoB) family; Region: FeoB; cd01879 508765008370 G1 box; other site 508765008371 GTP/Mg2+ binding site [chemical binding]; other site 508765008372 Switch I region; other site 508765008373 G2 box; other site 508765008374 G3 box; other site 508765008375 Switch II region; other site 508765008376 G4 box; other site 508765008377 G5 box; other site 508765008378 Nucleoside recognition; Region: Gate; pfam07670 508765008379 Ferrous iron transport protein B C terminus; Region: FeoB_C; pfam07664 508765008380 Nucleoside recognition; Region: Gate; pfam07670 508765008381 Fe2+ transport system protein A [Inorganic ion transport and metabolism]; Region: FeoA; COG1918 508765008382 coenzyme A disulfide reductase; Reviewed; Region: PRK09564 508765008383 Malate:quinone oxidoreductase (Mqo); Region: Mqo; cl17341 508765008384 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 508765008385 Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain; Region: Pyr_redox_dim; pfam02852 508765008386 Haloacid dehalogenase-like hydrolase; Region: HAD_2; pfam13419 508765008387 putative DNA modification/repair radical SAM protein; Region: rSAM_link_UDG; TIGR03916 508765008388 probable DNA metabolism protein; Region: SAM_7_link_chp; TIGR03915 508765008389 Peptidase family M13 includes neprilysin, endothelin-converting enzyme I; Region: M13; cd08662 508765008390 Predicted metalloendopeptidase [Posttranslational modification, protein turnover, chaperones]; Region: PepO; COG3590 508765008391 active site 508765008392 Zn binding site [ion binding]; other site 508765008393 Spore coat associated protein JA (CotJA); Region: CotJA; pfam11007 508765008394 CotJB protein; Region: CotJB; pfam12652 508765008395 Manganese catalase, ferritin-like diiron-binding domain; Region: Mn_catalase; cd01051 508765008396 dimanganese center [ion binding]; other site 508765008397 sulfite reductase, subunit C; Region: sulfite_red_C; TIGR02912 508765008398 Nitrite/Sulfite reductase ferredoxin-like half domain; Region: NIR_SIR_ferr; pfam03460 508765008399 4Fe-4S binding domain; Region: Fer4; pfam00037 508765008400 anaerobic sulfite reductase subunit B; Provisional; Region: PRK08221 508765008401 Anaerobic sulfite reductase contains an FAD and NADPH binding module with structural similarity to ferredoxin reductase and sequence similarity to dihydroorotate dehydrogenases. Clostridium pasteurianum inducible dissimilatory type sulfite reductase is...; Region: sulfite_reductase_like; cd06221 508765008402 FAD binding pocket [chemical binding]; other site 508765008403 FAD binding motif [chemical binding]; other site 508765008404 phosphate binding motif [ion binding]; other site 508765008405 beta-alpha-beta structure motif; other site 508765008406 NAD binding pocket [chemical binding]; other site 508765008407 Iron coordination center [ion binding]; other site 508765008408 anaerobic sulfite reductase subunit A; Provisional; Region: PRK15055 508765008409 Formate/nitrite transporter; Region: Form_Nir_trans; pfam01226 508765008410 cAMP-binding proteins - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases [Signal transduction mechanisms]; Region: Crp; COG0664 508765008411 effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038 508765008412 ligand binding site [chemical binding]; other site 508765008413 flexible hinge region; other site 508765008414 Crp-like helix-turn-helix domain; Region: HTH_Crp_2; pfam13545 508765008415 putative switch regulator; other site 508765008416 non-specific DNA interactions [nucleotide binding]; other site 508765008417 DNA binding site [nucleotide binding] 508765008418 sequence specific DNA binding site [nucleotide binding]; other site 508765008419 putative cAMP binding site [chemical binding]; other site 508765008420 Helix-turn-helix domain; Region: HTH_17; pfam12728 508765008421 PBP superfamily domain; Region: PBP_like; pfam12727 508765008422 ABC-type molybdate transport system, periplasmic component [Inorganic ion transport and metabolism]; Region: ModA; COG0725 508765008423 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; cl17199 508765008424 putative oxidoreductase; Provisional; Region: PRK12831 508765008425 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450 508765008426 ferredoxin-NADP(+) reductase subunit alpha; Reviewed; Region: PRK06222 508765008427 FAD/NAD binding domain in the electron transfer subunit of dihydroorotate dehydrogenase-like proteins. Dihydroorotate dehydrogenases (DHODs) catalyze the only redox reaction in pyrimidine de novo biosynthesis. They catalyze the oxidation of (S)...; Region: DHOD_e_trans_like1; cd06219 508765008428 FAD binding pocket [chemical binding]; other site 508765008429 FAD binding motif [chemical binding]; other site 508765008430 phosphate binding motif [ion binding]; other site 508765008431 beta-alpha-beta structure motif; other site 508765008432 NAD binding pocket [chemical binding]; other site 508765008433 Iron coordination center [ion binding]; other site 508765008434 Small protein B (SmpB) is a component of the trans-translation system in prokaryotes for releasing stalled ribosome from damaged messenger RNAs; Region: SmpB; cd09294 508765008435 SmpB-tmRNA interface; other site 508765008436 ribonuclease R; Region: RNase_R; TIGR02063 508765008437 Ribonuclease B OB domain; Region: OB_RNB; pfam08206 508765008438 Ribonuclease B OB domain; Region: OB_RNB; pfam08206 508765008439 RNB domain; Region: RNB; pfam00773 508765008440 S1_RNase_R: RNase R C-terminal S1 domain. RNase R is a processive 3' to 5' exoribonuclease, which is a homolog of RNase II. RNase R degrades RNA with secondary structure having a 3' overhang of at least 7 nucleotides. RNase R and PNPase...; Region: S1_RNase_R; cd04471 508765008441 RNA binding site [nucleotide binding]; other site 508765008442 H(+) -translocating inorganic pyrophosphatase; Region: PLN02255; cl11452 508765008443 Inorganic H+ pyrophosphatase; Region: H_PPase; pfam03030 508765008444 Preprotein translocase SecG subunit; Region: SecG; pfam03840 508765008445 enolase; Provisional; Region: eno; PRK00077 508765008446 Enolase: Enolases are homodimeric enzymes that catalyse the reversible dehydration of 2-phospho-D-glycerate to phosphoenolpyruvate as part of the glycolytic and gluconeogenesis pathways. The reaction is facilitated by the presence of metal ions; Region: enolase; cd03313 508765008447 dimer interface [polypeptide binding]; other site 508765008448 metal binding site [ion binding]; metal-binding site 508765008449 substrate binding pocket [chemical binding]; other site 508765008450 Protein Kinases, catalytic domain; Region: PKc_like; cl09925 508765008451 active site 508765008452 ATP binding site [chemical binding]; other site 508765008453 substrate binding site [chemical binding]; other site 508765008454 Phosphoglyceromutase [Carbohydrate transport and metabolism]; Region: GpmI; COG0696 508765008455 phosphoglyceromutase; Provisional; Region: PRK05434 508765008456 N-acetylmuramic acid-6-phosphate etherase; Reviewed; Region: murQ; PRK05441 508765008457 N-acetylmuramic acid 6-phosphate etherase. Members of this family contain the SIS (Sugar ISomerase) domain. The SIS domain is found in many phosphosugar isomerases and phosphosugar binding proteins. The bacterial cell wall sugar N-acetylmuramic acid...; Region: SIS_Etherase; cd05007 508765008458 putative active site [active] 508765008459 PTS system N-acetylmuramic acid transporter subunits EIIBC; Reviewed; Region: murP; PRK09586 508765008460 PTS_IIB, PTS system, glucose/sucrose specific IIB subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIB_glc; cd00212 508765008461 active site turn [active] 508765008462 phosphorylation site [posttranslational modification] 508765008463 Phosphotransferase system IIC components, glucose/maltose/N-acetylglucosamine-specific [Carbohydrate transport and metabolism]; Region: PtsG; COG1263 508765008464 Uncharacterized conserved protein [Function unknown]; Region: COG3589 508765008465 Bacterial protein of unknown function (DUF871); Region: DUF871; pfam05913 508765008466 Sensory domain found in PocR; Region: PocR; pfam10114 508765008467 Predicted sensor domain [Signal transduction mechanisms / Transcription]; Region: PocR; COG4936 508765008468 Methyl-accepting chemotaxis protein [Cell motility and secretion / Signal transduction mechanisms]; Region: Tar; COG0840 508765008469 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 508765008470 dimer interface [polypeptide binding]; other site 508765008471 putative CheW interface [polypeptide binding]; other site 508765008472 triosephosphate isomerase; Provisional; Region: PRK14567 508765008473 Triosephosphate isomerase (TIM) is a glycolytic enzyme that catalyzes the interconversion of dihydroxyacetone phosphate and D-glyceraldehyde-3-phosphate. The reaction is very efficient and requires neither cofactors nor metal ions. TIM, usually...; Region: TIM; cd00311 508765008474 substrate binding site [chemical binding]; other site 508765008475 dimer interface [polypeptide binding]; other site 508765008476 catalytic triad [active] 508765008477 Phosphoglycerate kinase; Region: PGK; pfam00162 508765008478 Phosphoglycerate kinase (PGK) is a monomeric enzyme which catalyzes the transfer of the high-energy phosphate group of 1,3-bisphosphoglycerate to ADP, forming ATP and 3-phosphoglycerate. This reaction represents the first of the two substrate-level...; Region: Phosphoglycerate_kinase; cd00318 508765008479 substrate binding site [chemical binding]; other site 508765008480 hinge regions; other site 508765008481 ADP binding site [chemical binding]; other site 508765008482 catalytic site [active] 508765008483 Glyceraldehyde 3-phosphate dehydrogenase, NAD binding domain; Region: Gp_dh_N; smart00846 508765008484 glyceraldehyde-3-phosphate dehydrogenase, type I; Region: GAPDH-I; TIGR01534 508765008485 Glyceraldehyde 3-phosphate dehydrogenase, C-terminal domain; Region: Gp_dh_C; pfam02800 508765008486 Transcriptional regulator, contains sigma factor-related N-terminal domain [Transcription]; Region: DeoR; COG2390 508765008487 Predicted transcriptional regulator [Transcription]; Region: COG3388 508765008488 Putative sugar-binding domain; Region: Sugar-bind; pfam04198 508765008489 RNA polymerase factor sigma-54; Reviewed; Region: PRK05932 508765008490 Sigma-54 factor, Activator interacting domain (AID); Region: Sigma54_AID; pfam00309 508765008491 Sigma-54 factor, core binding domain; Region: Sigma54_CBD; pfam04963 508765008492 Sigma-54, DNA binding domain; Region: Sigma54_DBD; pfam04552 508765008493 EDD domain protein, DegV family; Region: DegV; TIGR00762 508765008494 Uncharacterized protein, DegV family COG1307; Region: DegV; pfam02645 508765008495 Predicted rRNA methylase (SpoU class) [Translation, ribosomal structure and biogenesis]; Region: CspR; COG0219 508765008496 Putative peptidoglycan binding domain; Region: PG_binding_4; pfam12229 508765008497 VanW like protein; Region: VanW; pfam04294 508765008498 G5 domain; Region: G5; pfam07501 508765008499 Endo-N-acetylmuramidases (muramidases) are lysozymes (also referred to as peptidoglycan hydrolases) that degrade bacterial cell walls by catalyzing the hydrolysis of 1,4-beta-linkages between N-acetylmuramic acid and N-acetyl-D-glucosamine residues; Region: GH25_muramidase; cd00599 508765008500 active site 508765008501 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 508765008502 dimerization interface [polypeptide binding]; other site 508765008503 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 508765008504 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 508765008505 dimer interface [polypeptide binding]; other site 508765008506 phosphorylation site [posttranslational modification] 508765008507 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 508765008508 ATP binding site [chemical binding]; other site 508765008509 Mg2+ binding site [ion binding]; other site 508765008510 G-X-G motif; other site 508765008511 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 508765008512 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 508765008513 active site 508765008514 phosphorylation site [posttranslational modification] 508765008515 intermolecular recognition site; other site 508765008516 dimerization interface [polypeptide binding]; other site 508765008517 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 508765008518 DNA binding site [nucleotide binding] 508765008519 D-alanine--D-alanine ligase; Reviewed; Region: ddl; PRK01372 508765008520 D-ala D-ala ligase N-terminus; Region: Dala_Dala_lig_N; pfam01820 508765008521 ATP-grasp domain; Region: ATP-grasp_4; cl17255 508765008522 Predicted EndoIII-related endonuclease [DNA replication, recombination, and repair]; Region: Nth; COG0177 508765008523 endonuclease III; includes endonuclease III (DNA-(apurinic or apyrimidinic site) lyase), alkylbase DNA glycosidases (Alka-family) and other DNA glycosidases; Region: ENDO3c; cd00056 508765008524 minor groove reading motif; other site 508765008525 helix-hairpin-helix signature motif; other site 508765008526 substrate binding pocket [chemical binding]; other site 508765008527 active site 508765008528 Iron-sulfur binding domain of endonuclease III; Region: EndIII_4Fe-2S; pfam10576 508765008529 1-acyl-sn-glycerol-3-phosphate acyltransferase [Lipid metabolism]; Region: PlsC; COG0204 508765008530 Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: AGPAT-like; Region: LPLAT_AGPAT-like; cd07989 508765008531 putative acyl-acceptor binding pocket; other site 508765008532 Domain of unknown function (DUF1730); Region: DUF1730; pfam08331 508765008533 4Fe-4S double cluster binding domain; Region: Fer4_16; pfam13484 508765008534 serine O-acetyltransferase; Region: cysE; TIGR01172 508765008535 Serine acetyltransferase (SAT): SAT catalyzes the CoA-dependent acetylation of the side chain hydroxyl group of L-serine to form O-acetylserine, as the first step of a two-step biosynthetic pathway in bacteria and plants leading to the formation of...; Region: LbH_SAT; cd03354 508765008536 trimer interface [polypeptide binding]; other site 508765008537 active site 508765008538 substrate binding site [chemical binding]; other site 508765008539 CoA binding site [chemical binding]; other site 508765008540 Cysteine synthase [Amino acid transport and metabolism]; Region: CysK; COG0031 508765008541 CBS_like: This subgroup includes Cystathionine beta-synthase (CBS) and Cysteine synthase. CBS is a unique heme-containing enzyme that catalyzes a pyridoxal 5'-phosphate (PLP)-dependent condensation of serine and homocysteine to give cystathionine; Region: CBS_like; cd01561 508765008542 dimer interface [polypeptide binding]; other site 508765008543 pyridoxal 5'-phosphate binding site [chemical binding]; other site 508765008544 catalytic residue [active] 508765008545 T-box leader 508765008546 Mg/Co/Ni transporter MgtE (contains CBS domain) [Inorganic ion transport and metabolism]; Region: MgtE; COG2239 508765008547 MgtE intracellular N domain; Region: MgtE_N; smart00924 508765008548 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domain in the magnesium transporter, MgtE. MgtE and its homologs are found in eubacteria, archaebacteria, and eukaryota. Members of this family transport Mg2+ or other...; Region: CBS_pair_Mg_transporter; cd04606 508765008549 Radical SAM N-terminal; Region: Radical_SAM_N; pfam08497 508765008550 hypothetical protein; Provisional; Region: PRK00955 508765008551 Domain of unknown function (DUF3362); Region: DUF3362; pfam11842 508765008552 putative septicolysin, cholesterol-dependent cytolysin family and related proteins; Region: septicolysin_like; cd12208 508765008553 oligomer interface [polypeptide binding]; other site 508765008554 putative lipid kinase; Reviewed; Region: PRK13059 508765008555 Diacylglycerol kinase catalytic domain; Region: DAGK_cat; pfam00781 508765008556 CDP-alcohol phosphatidyltransferase; Region: CDP-OH_P_transf; pfam01066 508765008557 CDP-diacylglycerol--serine O-phosphatidyltransferase; Region: pssA; TIGR00473 508765008558 Rubrerythrin [Energy production and conversion]; Region: COG1592 508765008559 Rubrerythrin, ferritin-like diiron-binding domain; Region: Rubrerythrin; cd01041 508765008560 binuclear metal center [ion binding]; other site 508765008561 Rubredoxin, Small Modular nonheme iron binding domain containing a [Fe(SCys)4] center, present in rubrerythrin and nigerythrin and detected either N- or C-terminal to such proteins as flavin reductase, NAD(P)H-nitrite reductase, and...; Region: rubredoxin_SM; cd00729 508765008562 iron binding site [ion binding]; other site 508765008563 Uncharacterized conserved protein [Function unknown]; Region: SpoVR; COG2719 508765008564 SpoVR like protein; Region: SpoVR; pfam04293 508765008565 hypothetical protein; Provisional; Region: PRK05325 508765008566 Putative Ser protein kinase [Signal transduction mechanisms]; Region: PrkA; COG2766 508765008567 PrkA serine protein kinase C-terminal domain; Region: PrkA; pfam06798 508765008568 ATP-dependent DNA helicase RecQ; Region: recQ; TIGR01389 508765008569 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 508765008570 ATP binding site [chemical binding]; other site 508765008571 putative Mg++ binding site [ion binding]; other site 508765008572 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 508765008573 nucleotide binding region [chemical binding]; other site 508765008574 ATP-binding site [chemical binding]; other site 508765008575 This DNA-binding domain is found in the RecQ helicase among others and has a helix-turn-helix structure; Region: RQC; smart00956 508765008576 HRDC domain; Region: HRDC; pfam00570 508765008577 FtsX-like permease family; Region: FtsX; pfam02687 508765008578 ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136 508765008579 ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255 508765008580 Walker A/P-loop; other site 508765008581 ATP binding site [chemical binding]; other site 508765008582 Q-loop/lid; other site 508765008583 ABC transporter signature motif; other site 508765008584 Walker B; other site 508765008585 D-loop; other site 508765008586 H-loop/switch region; other site 508765008587 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 508765008588 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 508765008589 ATP binding site [chemical binding]; other site 508765008590 Mg2+ binding site [ion binding]; other site 508765008591 G-X-G motif; other site 508765008592 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 508765008593 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 508765008594 active site 508765008595 phosphorylation site [posttranslational modification] 508765008596 intermolecular recognition site; other site 508765008597 dimerization interface [polypeptide binding]; other site 508765008598 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 508765008599 DNA binding site [nucleotide binding] 508765008600 Rubrerythrin, ferritin-like diiron-binding domain; Region: Rubrerythrin; cd01041 508765008601 Rubrerythrin [Energy production and conversion]; Region: COG1592 508765008602 binuclear metal center [ion binding]; other site 508765008603 Rubredoxin_like; nonheme iron binding domain containing a [Fe(SCys)4] center. The family includes rubredoxins, a small electron transfer protein, and a slightly smaller modular rubredoxin domain present in rubrerythrin and nigerythrin and detected either...; Region: rubredoxin_like; cd00350 508765008604 iron binding site [ion binding]; other site 508765008605 Predicted esterase of the alpha-beta hydrolase superfamily [General function prediction only]; Region: RssA; COG1752 508765008606 ExoU and VipD-like proteins; homologus to patatin, cPLA2, and iPLA2; Region: Pat_ExoU_VipD_like; cd07207 508765008607 nucleophile elbow; other site 508765008608 Thiamine monophosphate synthase (TMP synthase)/TenI. TMP synthase catalyzes an important step in the thiamine biosynthesis pathway, the substitution of the pyrophosphate of 2-methyl-4-amino-5- hydroxymethylpyrimidine pyrophosphate by 4-methyl-5-; Region: TMP_TenI; cd00564 508765008609 thiamine phosphate binding site [chemical binding]; other site 508765008610 active site 508765008611 pyrophosphate binding site [ion binding]; other site 508765008612 4-methyl-5-beta-hydroxyethylthiazole (Thz) kinase catalyzes the phosphorylation of the hydroxylgroup of Thz. A reaction that allows cells to recycle Thz into the thiamine biosynthesis pathway, as an alternative to its synthesis from cysteine, tyrosine...; Region: THZ_kinase; cd01170 508765008613 substrate binding site [chemical binding]; other site 508765008614 multimerization interface [polypeptide binding]; other site 508765008615 ATP binding site [chemical binding]; other site 508765008616 4-amino-5-hydroxymethyl-2-methyl-pyrimidine phosphate kinase (HMPP-kinase) catalyzes two consecutive phosphorylation steps in the thiamine phosphate biosynthesis pathway, leading to the synthesis of vitamin B1. The first step is the phosphorylation of...; Region: HMPP_kinase; cd01169 508765008617 dimer interface [polypeptide binding]; other site 508765008618 substrate binding site [chemical binding]; other site 508765008619 ATP binding site [chemical binding]; other site 508765008620 Thiamine-precursor transporter protein (ThiW); Region: ThiW; pfam09512 508765008621 Serine dehydratase alpha chain; Region: SDH_alpha; cl12120 508765008622 L-serine deaminase [Amino acid transport and metabolism]; Region: SdaA; COG1760 508765008623 L-serine dehydratase, iron-sulfur-dependent, beta subunit; Region: sda_beta; TIGR00719 508765008624 Serine dehydratase beta chain; Region: SDH_beta; pfam03315 508765008625 C-terminal ACT domain of the L-serine dehydratase (LSD), iron-sulfur-dependent, beta subunit; Region: ACT_LSD; cd04903 508765008626 putative L-serine binding site [chemical binding]; other site 508765008627 Uridine kinase [Nucleotide transport and metabolism]; Region: Udk; COG0572 508765008628 Uridine monophosphate kinase_like (UMPK_like) is a family of proteins highly similar to the uridine monophosphate kinase (UMPK, EC 2.7.1.48), also known as uridine kinase or uridine-cytidine kinase (UCK); Region: UMPK_like; cd02028 508765008629 active site 508765008630 Predicted membrane protein [Function unknown]; Region: COG2323 508765008631 Domain of unknown function (DUF4363); Region: DUF4363; pfam14276 508765008632 Tagatose-1,6-bisphosphate (TBP) aldolase and related Type B Class II aldolases. TBP aldolase is a tetrameric class II aldolase that catalyzes the reversible condensation of dihydroxyacetone phosphate with glyceraldehyde 3-phsophate to produce tagatose 1; Region: TBP_aldolase_IIB; cd00947 508765008633 fructose-bisphosphate aldolase; Provisional; Region: PRK09197 508765008634 intersubunit interface [polypeptide binding]; other site 508765008635 active site 508765008636 zinc binding site [ion binding]; other site 508765008637 Na+ binding site [ion binding]; other site 508765008638 argininosuccinate synthase; Provisional; Region: PRK13820 508765008639 Argininosuccinate synthase. The Argininosuccinate synthase is a urea cycle enzyme that catalyzes the penultimate step in arginine biosynthesis: the ATP-dependent ligation of citrulline to aspartate to form argininosuccinate, AMP and pyrophosphate . In...; Region: Argininosuccinate_Synthase; cd01999 508765008640 ANP binding site [chemical binding]; other site 508765008641 Substrate Binding Site II [chemical binding]; other site 508765008642 Substrate Binding Site I [chemical binding]; other site 508765008643 argininosuccinate lyase; Provisional; Region: PRK00855 508765008644 Argininosuccinate lyase (argininosuccinase, ASAL); Region: Argininosuccinate_lyase; cd01359 508765008645 active sites [active] 508765008646 tetramer interface [polypeptide binding]; other site 508765008647 N-acetyl-gamma-glutamyl-phosphate reductase; Validated; Region: argC; PRK00436 508765008648 Semialdehyde dehydrogenase, NAD binding domain; Region: Semialdhyde_dh; smart00859 508765008649 Ornithine acetyltransferase (OAT) family; also referred to as ArgJ. OAT catalyzes the first and fifth steps in arginine biosynthesis, coupling acetylation of glutamate with deacetylation of N-acetylornithine, which allows recycling of the acetyl group in...; Region: OAT; cd02152 508765008650 heterotetramer interface [polypeptide binding]; other site 508765008651 active site pocket [active] 508765008652 cleavage site 508765008653 AAK_NAGK-C: N-Acetyl-L-glutamate kinase - cyclic (NAGK-C) catalyzes the phosphorylation of the gamma-COOH group of N-acetyl-L-glutamate (NAG) by ATP in the second step of arginine biosynthesis found in some bacteria and photosynthetic organisms using the...; Region: AAK_NAGK-C; cd04250 508765008654 feedback inhibition sensing region; other site 508765008655 homohexameric interface [polypeptide binding]; other site 508765008656 nucleotide binding site [chemical binding]; other site 508765008657 N-acetyl-L-glutamate binding site [chemical binding]; other site 508765008658 acetylornithine aminotransferase; Provisional; Region: PRK02627 508765008659 Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610 508765008660 inhibitor-cofactor binding pocket; inhibition site 508765008661 pyridoxal 5'-phosphate binding site [chemical binding]; other site 508765008662 catalytic residue [active] 508765008663 ornithine carbamoyltransferase; Provisional; Region: PRK00779 508765008664 Aspartate/ornithine carbamoyltransferase, carbamoyl-P binding domain; Region: OTCace_N; pfam02729 508765008665 Aspartate/ornithine carbamoyltransferase, Asp/Orn binding domain; Region: OTCace; pfam00185 508765008666 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 508765008667 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 508765008668 metal binding site [ion binding]; metal-binding site 508765008669 active site 508765008670 I-site; other site 508765008671 37-kD nucleoid-associated bacterial protein; Region: NA37; pfam04245 508765008672 Adenylyl cyclase (AC) class IV-like, a subgroup of the CYTH-like superfamily; Region: CYTH-like_AC_IV-like; cd07890 508765008673 putative active site [active] 508765008674 putative metal binding residues [ion binding]; other site 508765008675 signature motif; other site 508765008676 putative triphosphate binding site [ion binding]; other site 508765008677 dimer interface [polypeptide binding]; other site 508765008678 Phosphomannose isomerase [Carbohydrate transport and metabolism]; Region: ManA; COG1482 508765008679 Alpha-Mannosidase Binding Domain of Atg19/34; Region: ABD; cl15429 508765008680 Fructose-1-phosphate kinase and related fructose-6-phosphate kinase (PfkB) [Carbohydrate transport and metabolism]; Region: FruK; COG1105 508765008681 1-phosphofructokinase (FruK), minor 6-phosphofructokinase (pfkB) and related sugar kinases. FruK plays an important role in the predominant pathway for fructose utilisation.This group also contains tagatose-6-phophate kinase, an enzyme of the tagatose...; Region: FruK_PfkB_like; cd01164 508765008682 putative substrate binding site [chemical binding]; other site 508765008683 putative ATP binding site [chemical binding]; other site 508765008684 Tagatose-1,6-bisphosphate (TBP) aldolase and related Type B Class II aldolases. TBP aldolase is a tetrameric class II aldolase that catalyzes the reversible condensation of dihydroxyacetone phosphate with glyceraldehyde 3-phsophate to produce tagatose 1; Region: TBP_aldolase_IIB; cd00947 508765008685 fructose-bisphosphate aldolase; Provisional; Region: PRK09197 508765008686 intersubunit interface [polypeptide binding]; other site 508765008687 active site 508765008688 zinc binding site [ion binding]; other site 508765008689 Na+ binding site [ion binding]; other site 508765008690 PTS_IIA, PTS system, mannose/sorbose specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIA_man; cd00006 508765008691 active pocket/dimerization site; other site 508765008692 active site 508765008693 phosphorylation site [posttranslational modification] 508765008694 putative sugar isomerase, AgaS family; Region: agaS_fam; TIGR02815 508765008695 SIS (Sugar ISomerase) domain repeat 1 found in Glucosamine 6-phosphate synthase (GlmS) and Glucosamine-6-phosphate deaminase (GlmD). The SIS domain is found in many phosphosugar isomerases and phosphosugar binding proteins. GlmS contains a N-terminal...; Region: SIS_GlmS_GlmD_1; cd05008 508765008696 dimer interface [polypeptide binding]; other site 508765008697 active site 508765008698 AgaS-like protein. AgaS contains a SIS (Sugar ISomerase) domain which is found in many phosphosugar isomerases and phosphosugar binding proteins. AgaS is a putative isomerase in Escherichia coli. It is similar to the glucosamine-6-phosphate synthases; Region: SIS_AgaS_like; cd05010 508765008699 putative active site [active] 508765008700 Transcriptional regulators [Transcription]; Region: PhnF; COG2188 508765008701 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 508765008702 DNA-binding site [nucleotide binding]; DNA binding site 508765008703 UTRA domain; Region: UTRA; pfam07702 508765008704 PTS system mannose/fructose/sorbose family IID component; Region: EIID-AGA; pfam03613 508765008705 PTS system sorbose-specific iic component; Region: EII-Sor; pfam03609 508765008706 PTS_IIB, PTS system, Mannose/sorbose specific IIB subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIB_man; cd00001 508765008707 active site 508765008708 phosphorylation site [posttranslational modification] 508765008709 N-acetylglucosamine-6-phosphate deacetylase [Carbohydrate transport and metabolism]; Region: NagA; COG1820 508765008710 N-acetylglucosamine-6-phosphate deacetylase, NagA, catalyzes the hydrolysis of the N-acetyl group of N-acetyl-glucosamine-6-phosphate (GlcNAc-6-P) to glucosamine 6-phosphate and acetate. This is the first committed step in the biosynthetic pathway to...; Region: NagA; cd00854 508765008711 active site 508765008712 dimer interface [polypeptide binding]; other site 508765008713 prephenate dehydrogenase; Validated; Region: PRK08507 508765008714 Prephenate dehydrogenase [Amino acid transport and metabolism]; Region: TyrA; COG0287 508765008715 3-deoxy-7-phosphoheptulonate synthase; Reviewed; Region: PRK08673 508765008716 phospho-2-dehydro-3-deoxyheptonate aldolase; Region: DAHP_synth_Bsub; TIGR01361 508765008717 Shikimate kinase [Amino acid transport and metabolism]; Region: AroK; COG0703 508765008718 Shikimate kinase (SK) is the fifth enzyme in the shikimate pathway, a seven-step biosynthetic pathway which converts erythrose-4-phosphate to chorismic acid, found in bacteria, fungi and plants. Chorismic acid is a important intermediate in the synthesis...; Region: SK; cd00464 508765008719 ADP binding site [chemical binding]; other site 508765008720 magnesium binding site [ion binding]; other site 508765008721 putative shikimate binding site; other site 508765008722 Shikimate 5-dehydrogenase [Amino acid transport and metabolism]; Region: AroE; COG0169 508765008723 Shikimate dehydrogenase substrate binding domain; Region: Shikimate_dh_N; pfam08501 508765008724 NAD(P) binding domain of Shikimate dehydrogenase; Region: NAD_bind_Shikimate_DH; cd01065 508765008725 shikimate binding site; other site 508765008726 NAD(P) binding site [chemical binding]; other site 508765008727 Chorismate mutase type II; Region: CM_2; smart00830 508765008728 Prephenate dehydratase [Amino acid transport and metabolism]; Region: PheA; COG0077 508765008729 Prephenate dehydratase; Region: PDT; pfam00800 508765008730 C-terminal ACT domain of the bifunctional chorismate mutase-prephenate dehydratase (CM-PDT) enzyme and the prephenate dehydratase (PDT) enzyme; Region: ACT_CM-PDT; cd04905 508765008731 putative L-Phe binding site [chemical binding]; other site 508765008732 Chorismate synthase [Amino acid transport and metabolism]; Region: AroC; COG0082 508765008733 Chorismase synthase, the enzyme catalyzing the final step of the shikimate pathway; Region: Chorismate_synthase; cd07304 508765008734 Tetramer interface [polypeptide binding]; other site 508765008735 active site 508765008736 FMN-binding site [chemical binding]; other site 508765008737 3-phosphoshikimate 1-carboxyvinyltransferase; Provisional; Region: PRK02427 508765008738 EPSP synthase domain. 3-phosphoshikimate 1-carboxyvinyltransferase (5-enolpyruvylshikimate-3-phosphate synthase) (EC 2.5.1.19) catalyses the reaction between shikimate-3-phosphate (S3P) and phosphoenolpyruvate (PEP) to form...; Region: EPSP_synthase; cd01556 508765008739 hinge; other site 508765008740 active site 508765008741 Dehydroquinate synthase (DHQS) catalyzes the conversion of DAHP to DHQ in shikimate pathway for aromatic compounds synthesis; Region: DHQS; cd08195 508765008742 active site 508765008743 dimer interface [polypeptide binding]; other site 508765008744 metal binding site [ion binding]; metal-binding site 508765008745 3-deoxy-7-phosphoheptulonate synthase; Reviewed; Region: PRK08673 508765008746 3-deoxy-D-manno-octulosonic acid (KDO) 8-phosphate synthase [Cell envelope biogenesis, outer membrane]; Region: KdsA; cl17225 508765008747 Chitinase [Carbohydrate transport and metabolism]; Region: ChiA; COG3325 508765008748 The GH18 (glycosyl hydrolases, family 18) type II chitinases hydrolyze chitin, an abundant polymer of N-acetylglucosamine and have been identified in bacteria, fungi, insects, plants, viruses, and protozoan parasites. The structure of this domain is an...; Region: GH18_chitinase; cd06548 508765008749 active site 508765008750 cardiolipin synthase; Region: bac_cardiolipin; TIGR04265 508765008751 Phospholipase_D-nuclease N-terminal; Region: PLDc_N; pfam13396 508765008752 Catalytic domain, repeat 1, of bacterial cardiolipin synthase and similar proteins; Region: PLDc_CLS_1; cd09110 508765008753 putative active site [active] 508765008754 catalytic site [active] 508765008755 catalytic domain repeat 2 of bacterial cardiolipin synthase and similar proteins; Region: PLDc_CLS_2; cd09112 508765008756 putative active site [active] 508765008757 catalytic site [active] 508765008758 Predicted symporter [General function prediction only]; Region: DhlC; COG4147 508765008759 Na(+)/proline cotransporter PutP and related proteins; solute binding domain; Region: SLC5sbd_PutP; cd11475 508765008760 Na binding site [ion binding]; other site 508765008761 T-box leader 508765008762 leucyl-tRNA synthetase; Validated; Region: leuS; PRK00390 508765008763 catalytic core domain of leucyl-tRNA synthetases; Region: LeuRS_core; cd00812 508765008764 HIGH motif; other site 508765008765 Leucyl-tRNA synthetase, Domain 2; Region: tRNA-synt_1_2; pfam13603 508765008766 nucleotidyl transferase superfamily; Region: nt_trans; cl00015 508765008767 active site 508765008768 KMSKS motif; other site 508765008769 Anticodon-binding domain of bacterial and eukaryotic mitochondrial leucyl tRNA synthetases; Region: Anticodon_Ia_Leu_BEm; cd07958 508765008770 tRNA binding surface [nucleotide binding]; other site 508765008771 Cache domain; Region: Cache_1; pfam02743 508765008772 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 508765008773 dimerization interface [polypeptide binding]; other site 508765008774 Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer); Region: MA; smart00283 508765008775 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 508765008776 dimer interface [polypeptide binding]; other site 508765008777 putative CheW interface [polypeptide binding]; other site 508765008778 Acetyltransferase (isoleucine patch superfamily) [General function prediction only]; Region: WbbJ; COG0110 508765008779 Maltose O-acyltransferase (MAT)-like: This family is composed of maltose O-acetyltransferase, galactoside O-acetyltransferase (GAT), xenobiotic acyltransferase (XAT) and similar proteins. MAT and GAT catalyze the CoA-dependent acetylation of the...; Region: LbH_MAT_like; cd04647 508765008780 trimer interface [polypeptide binding]; other site 508765008781 active site 508765008782 substrate binding site [chemical binding]; other site 508765008783 CoA binding site [chemical binding]; other site 508765008784 Iron-sulphur cluster biosynthesis; Region: Fe-S_biosyn; cl00400 508765008785 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3864 508765008786 Putative metallopeptidase domain; Region: DUF2201_N; pfam13203 508765008787 Von Willebrand factor type A (vWA) domain was originally found in the blood coagulation protein von Willebrand factor (vWF). Typically, the vWA domain is made up of approximately 200 amino acid residues folded into a classic a/b para-rossmann type of...; Region: vWFA; cl00057 508765008788 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 508765008789 ATPases associated with a variety of cellular activities; Region: AAA; smart00382 508765008790 Walker A motif; other site 508765008791 ATP binding site [chemical binding]; other site 508765008792 Walker B motif; other site 508765008793 Nucleotidyltransferase (NT) domain of RelA- and SpoT-like ppGpp synthetases and hydrolases; Region: NT_Rel-Spo_like; cd05399 508765008794 synthetase active site [active] 508765008795 NTP binding site [chemical binding]; other site 508765008796 metal binding site [ion binding]; metal-binding site 508765008797 Uncharacterized protein conserved in bacteria (DUF2225); Region: DUF2225; pfam09986 508765008798 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG1655 508765008799 Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer); Region: MA; smart00283 508765008800 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 508765008801 dimer interface [polypeptide binding]; other site 508765008802 putative CheW interface [polypeptide binding]; other site 508765008803 Stage II sporulation protein; Region: SpoIID; pfam08486 508765008804 Putative peptidoglycan-binding domain-containing protein [Cell envelope biogenesis, outer membrane]; Region: COG3409 508765008805 Putative peptidoglycan binding domain; Region: PG_binding_1; pfam01471 508765008806 Putative peptidoglycan-binding domain-containing protein [Cell envelope biogenesis, outer membrane]; Region: COG3409 508765008807 Putative peptidoglycan binding domain; Region: PG_binding_1; pfam01471 508765008808 Putative peptidoglycan-binding domain-containing protein [Cell envelope biogenesis, outer membrane]; Region: COG3409 508765008809 Putative peptidoglycan binding domain; Region: PG_binding_1; pfam01471 508765008810 Putative peptidoglycan-binding domain-containing protein [Cell envelope biogenesis, outer membrane]; Region: COG3409 508765008811 Putative peptidoglycan binding domain; Region: PG_binding_1; pfam01471 508765008812 Putative peptidoglycan binding domain; Region: PG_binding_1; pfam01471 508765008813 Deinococcus radiodurans DR1119 and related proteins, metallophosphatase domain; Region: MPP_DR1119; cd07393 508765008814 Calcineurin-like phosphoesterase; Region: Metallophos; pfam00149 508765008815 putative active site [active] 508765008816 putative metal binding site [ion binding]; other site 508765008817 Uncharacterized homolog of the cytoplasmic domain of flagellar protein FhlB [Function unknown]; Region: COG2257 508765008818 tyrosyl-tRNA synthetase; Validated; Region: PRK05912 508765008819 catalytic core domain of tyrosinyl-tRNA synthetase; Region: TyrRS_core; cd00805 508765008820 active site 508765008821 HIGH motif; other site 508765008822 dimer interface [polypeptide binding]; other site 508765008823 KMSKS motif; other site 508765008824 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 508765008825 RNA binding surface [nucleotide binding]; other site 508765008826 germination protein, Ger(x)C family; Region: spore_ger_x_C; TIGR02887 508765008827 Spore germination B3/ GerAC like, C-terminal; Region: Spore_GerAC; pfam05504 508765008828 Bacillus/Clostridium GerA spore germination protein; Region: GerA; pfam03323 508765008829 Spore germination protein; Region: Spore_permease; cl17796 508765008830 ECF-type riboflavin transporter, S component; Region: ECF-ribofla_trS; pfam07155 508765008831 tryptophanyl-tRNA synthetase II; Reviewed; Region: PRK12282 508765008832 catalytic core domain of tryptophanyl-tRNA synthetase; Region: TrpRS_core; cd00806 508765008833 active site 508765008834 HIGH motif; other site 508765008835 dimer interface [polypeptide binding]; other site 508765008836 KMSKS motif; other site 508765008837 Prokaryotic UGPase catalyses the synthesis of UDP-glucose; Region: UGPase_prokaryotic; cd02541 508765008838 dTDP-glucose pyrophosphorylase [Cell envelope biogenesis, outer membrane]; Region: RfbA; COG1209 508765008839 active site 508765008840 tetramer interface; other site 508765008841 Branched-chain amino acid transport protein; Region: Branch_AA_trans; cl00547 508765008842 Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673 508765008843 Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408 508765008844 Oxidoreductase family, C-terminal alpha/beta domain; Region: GFO_IDH_MocA_C; pfam02894 508765008845 Bacterial sugar transferase; Region: Bac_transf; pfam02397 508765008846 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 508765008847 This family is most closely related to the GT1 family of glycosyltransferases. wbuB in E. coli is involved in the biosynthesis of the O26 O-antigen. It has been proposed to function as an N-acetyl-L-fucosamine (L-FucNAc) transferase; Region: GT1_wbuB_like; cd03794 508765008848 FOG: Glucan-binding domain (YG repeat) [General function prediction only]; Region: COG5263 508765008849 FOG: Glucan-binding domain (YG repeat) [General function prediction only]; Region: COG5263 508765008850 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 508765008851 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 508765008852 dimerization interface [polypeptide binding]; other site 508765008853 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 508765008854 dimer interface [polypeptide binding]; other site 508765008855 phosphorylation site [posttranslational modification] 508765008856 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 508765008857 Mg2+ binding site [ion binding]; other site 508765008858 G-X-G motif; other site 508765008859 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 508765008860 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 508765008861 active site 508765008862 phosphorylation site [posttranslational modification] 508765008863 intermolecular recognition site; other site 508765008864 dimerization interface [polypeptide binding]; other site 508765008865 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 508765008866 DNA binding site [nucleotide binding] 508765008867 Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013 508765008868 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 508765008869 Bacterial members of the UDP-N-Acetylglucosamine (GlcNAc) 2-Epimerase family are known to catalyze the reversible interconversion of UDP-GlcNAc and UDP-N-acetylmannosamine (UDP-ManNAc). The enzyme serves to produce an activated form of ManNAc residues; Region: GT1_UDP-GlcNAc_2-Epimerase; cd03786 508765008870 active site 508765008871 UDP-N-acetylglucosamine 2-epimerase; Region: Epimerase_2; pfam02350 508765008872 homodimer interface [polypeptide binding]; other site 508765008873 O-Antigen ligase; Region: Wzy_C; pfam04932 508765008874 Predicted nucleoside-diphosphate sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: COG1086 508765008875 UDP-Glcnac (UDP-linked N-acetylglucosamine) inverting 4,6-dehydratase, extended (e) SDRs; Region: UDP_invert_4-6DH_SDR_e; cd05237 508765008876 NAD(P) binding site [chemical binding]; other site 508765008877 homodimer interface [polypeptide binding]; other site 508765008878 substrate binding site [chemical binding]; other site 508765008879 active site 508765008880 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394 508765008881 active site 508765008882 LicD family; Region: LicD; pfam04991 508765008883 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cd00761 508765008884 active site 508765008885 ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395 508765008886 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 508765008887 dimer interface [polypeptide binding]; other site 508765008888 conserved gate region; other site 508765008889 putative PBP binding loops; other site 508765008890 ABC-ATPase subunit interface; other site 508765008891 ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395 508765008892 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 508765008893 dimer interface [polypeptide binding]; other site 508765008894 conserved gate region; other site 508765008895 putative PBP binding loops; other site 508765008896 ABC-ATPase subunit interface; other site 508765008897 ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653 508765008898 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; cl17199 508765008899 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 508765008900 haloacid dehalogenase-like hydrolase; Region: Hydrolase_3; pfam08282 508765008901 active site 508765008902 motif I; other site 508765008903 motif II; other site 508765008904 haloacid dehalogenase-like hydrolase; Region: HAD; cl17202 508765008905 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 508765008906 dimerization interface [polypeptide binding]; other site 508765008907 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 508765008908 PAS fold; Region: PAS_3; pfam08447 508765008909 putative active site [active] 508765008910 heme pocket [chemical binding]; other site 508765008911 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 508765008912 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 508765008913 metal binding site [ion binding]; metal-binding site 508765008914 active site 508765008915 I-site; other site 508765008916 Permeases of the drug/metabolite transporter (DMT) superfamily [Carbohydrate transport and metabolism / Amino acid transport and metabolism / General function prediction only]; Region: RhaT; COG0697 508765008917 Multidrug resistance efflux transporter; Region: EmrE; pfam13536 508765008918 EamA-like transporter family; Region: EamA; cl17759 508765008919 Putative cell wall binding repeat; Region: CW_binding_1; pfam01473 508765008920 Membrane protein involved in the export of O-antigen and teichoic acid [General function prediction only]; Region: RfbX; COG2244 508765008921 Wzx, a subfamily of the multidrug and toxic compound extrusion (MATE)-like proteins; Region: MATE_Wzx_like; cd13128 508765008922 Nucleoside-diphosphate-sugar pyrophosphorylase involved in lipopolysaccharide biosynthesis/translation initiation factor 2B, gamma/epsilon subunits (eIF-2Bgamma/eIF-2Bepsilon) [Cell envelope biogenesis, outer membrane / Translation, ribosomal structure...; Region: GCD1; COG1208 508765008923 Phosphocholine cytidylyltransferases catalyze the synthesis of CDP-choline; Region: PC_cytidylyltransferase; cd02523 508765008924 active site 508765008925 metal-binding site 508765008926 Phosphocholine cytidylyltransferases catalyze the synthesis of CDP-choline; Region: PC_cytidylyltransferase; cd02523 508765008927 active site 508765008928 metal-binding site 508765008929 Phosphotransferase enzyme family; Region: APH; pfam01636 508765008930 Choline Kinase (ChoK). The ChoK subfamily is part of a larger superfamily that includes the catalytic domains of other kinases, such as the typical serine/threonine/tyrosine protein kinases (PKs), RIO kinases, actin-fragmin kinase (AFK), and...; Region: ChoK; cd05151 508765008931 active site 508765008932 ATP binding site [chemical binding]; other site 508765008933 substrate binding site [chemical binding]; other site 508765008934 dimer interface [polypeptide binding]; other site 508765008935 YcxB-like protein; Region: YcxB; pfam14317 508765008936 Cadherin-like beta sandwich domain; Region: Cadherin-like; pfam12733 508765008937 Cadherin-like beta sandwich domain; Region: Cadherin-like; pfam12733 508765008938 FOG: Glucan-binding domain (YG repeat) [General function prediction only]; Region: COG5263 508765008939 Mannosyl-glycoprotein endo-beta-N-acetylglucosaminidase; Region: Glucosaminidase; pfam01832 508765008940 glucan-binding repeat; Region: glucan_65_rpt; TIGR04035 508765008941 glucan-binding repeat; Region: glucan_65_rpt; TIGR04035 508765008942 glucan-binding repeat; Region: glucan_65_rpt; TIGR04035 508765008943 N-acetylmuramoyl-L-alanine amidase [Cell envelope biogenesis, outer membrane]; Region: AmiC; COG0860 508765008944 N-acetylmuramoyl-L-alanine amidase or MurNAc-LAA (also known as peptidoglycan aminohydrolase, NAMLA amidase, NAMLAA, Amidase 3, and peptidoglycan amidase; EC 3.5.1.28) is an autolysin that hydrolyzes the amide bond between N-acetylmuramoyl and L-amino...; Region: MurNAc-LAA; cd02696 508765008945 active site 508765008946 metal binding site [ion binding]; metal-binding site 508765008947 Mannosyl-glycoprotein endo-beta-N-acetylglucosaminidase; Region: Glucosaminidase; pfam01832 508765008948 FOG: Glucan-binding domain (YG repeat) [General function prediction only]; Region: COG5263 508765008949 Putative cell wall binding repeat; Region: CW_binding_1; pfam01473 508765008950 glucan-binding repeat; Region: glucan_65_rpt; TIGR04035 508765008951 N-acetylmuramoyl-L-alanine amidase [Cell envelope biogenesis, outer membrane]; Region: AmiC; COG0860 508765008952 N-acetylmuramoyl-L-alanine amidase or MurNAc-LAA (also known as peptidoglycan aminohydrolase, NAMLA amidase, NAMLAA, Amidase 3, and peptidoglycan amidase; EC 3.5.1.28) is an autolysin that hydrolyzes the amide bond between N-acetylmuramoyl and L-amino...; Region: MurNAc-LAA; cd02696 508765008953 active site 508765008954 metal binding site [ion binding]; metal-binding site 508765008955 ATP cone domain; Region: ATP-cone; pfam03477 508765008956 Predicted hydrolases of the HAD superfamily [General function prediction only]; Region: Cof; COG0561 508765008957 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 508765008958 active site 508765008959 motif I; other site 508765008960 motif II; other site 508765008961 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 508765008962 Pyridoxal kinase plays a key role in the synthesis of the active coenzyme pyridoxal-5'-phosphate (PLP), by catalyzing the phosphorylation of the precursor vitamin B6 in the presence of Zn2+ and ATP. Mammals are unable to synthesize PLP de novo and...; Region: pyridoxal_pyridoxamine_kinase; cd01173 508765008963 dimer interface [polypeptide binding]; other site 508765008964 pyridoxal binding site [chemical binding]; other site 508765008965 ATP binding site [chemical binding]; other site 508765008966 TRX family; composed of two groups: Group I, which includes proteins that exclusively encode a TRX domain; and Group II, which are composed of fusion proteins of TRX and additional domains. Group I TRX is a small ancient protein that alter the redox...; Region: TRX_family; cd02947 508765008967 Thioredoxin-like; Region: Thioredoxin_8; pfam13905 508765008968 catalytic residues [active] 508765008969 Thioredoxin reductase [Posttranslational modification, protein turnover, chaperones]; Region: TrxB; COG0492 508765008970 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500 508765008971 Polymerase and Histidinol Phosphatase domain; Region: PHP; cl17102 508765008972 histidinol phosphate phosphatase, HisJ family; Region: hisJ_fam; TIGR01856 508765008973 active site 508765008974 Cache domain; Region: Cache_1; pfam02743 508765008975 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 508765008976 dimerization interface [polypeptide binding]; other site 508765008977 Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer); Region: MA; smart00283 508765008978 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 508765008979 dimer interface [polypeptide binding]; other site 508765008980 putative CheW interface [polypeptide binding]; other site 508765008981 putative oxidoreductase; Provisional; Region: PRK12831 508765008982 The HCP family of iron-sulfur proteins includes hybrid cluster protein (HCP), acetyl-CoA synthase (ACS), and carbon monoxide dehydrogenase (CODH), all of which contain [Fe4-S4] metal clusters at their active sites. These proteins have a conserved...; Region: HCP_like; cl14655 508765008983 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450 508765008984 ferredoxin-NADP(+) reductase subunit alpha; Reviewed; Region: PRK06222 508765008985 FAD/NAD binding domain in the electron transfer subunit of dihydroorotate dehydrogenase-like proteins. Dihydroorotate dehydrogenases (DHODs) catalyze the only redox reaction in pyrimidine de novo biosynthesis. They catalyze the oxidation of (S)...; Region: DHOD_e_trans_like1; cd06219 508765008986 FAD binding pocket [chemical binding]; other site 508765008987 FAD binding motif [chemical binding]; other site 508765008988 phosphate binding motif [ion binding]; other site 508765008989 beta-alpha-beta structure motif; other site 508765008990 NAD binding pocket [chemical binding]; other site 508765008991 Iron coordination center [ion binding]; other site 508765008992 Alcohol dehydrogenase, class IV [Energy production and conversion]; Region: EutG; COG1454 508765008993 NADPH-dependent butanol dehydrogenase involved in the butanol and ethanol formation pathway in bacteria; Region: NADPH_BDH; cd08179 508765008994 putative active site [active] 508765008995 metal binding site [ion binding]; metal-binding site 508765008996 Transcriptional activator of acetoin/glycerol metabolism [Secondary metabolites biosynthesis, transport, and catabolism / Transcription]; Region: AcoR; COG3284 508765008997 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 508765008998 Walker A motif; other site 508765008999 ATP binding site [chemical binding]; other site 508765009000 Walker B motif; other site 508765009001 arginine finger; other site 508765009002 Bacterial regulatory protein, Fis family; Region: HTH_8; pfam02954 508765009003 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3584 508765009004 peptide chain release factor 3; Provisional; Region: prfC; PRK00741 508765009005 Release Factor 3 (RF3) protein involved in the terminal step of translocation in bacteria; Region: RF3; cd04169 508765009006 G1 box; other site 508765009007 putative GEF interaction site [polypeptide binding]; other site 508765009008 GTP/Mg2+ binding site [chemical binding]; other site 508765009009 Switch I region; other site 508765009010 G2 box; other site 508765009011 G3 box; other site 508765009012 Switch II region; other site 508765009013 G4 box; other site 508765009014 G5 box; other site 508765009015 RF3_II: this subfamily represents the domain II of bacterial Release Factor 3 (RF3). Termination of protein synthesis by the ribosome requires two release factor (RF) classes. The class II RF3 is a GTPase that removes class I RFs (RF1 or RF2) from the...; Region: RF3_II; cd03689 508765009016 FOG: Glucan-binding domain (YG repeat) [General function prediction only]; Region: COG5263 508765009017 Putative cell wall binding repeat; Region: CW_binding_1; pfam01473 508765009018 Listeria-Bacteroides repeat domain (List_Bact_rpt); Region: Flg_new; pfam09479 508765009019 Tetratricopeptide repeat; Region: TPR_12; pfam13424 508765009020 FOG: GAF domain [Signal transduction mechanisms]; Region: FhlA; COG2203 508765009021 GAF domain; Region: GAF_3; pfam13492 508765009022 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 508765009023 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 508765009024 metal binding site [ion binding]; metal-binding site 508765009025 active site 508765009026 I-site; other site 508765009027 Cadherin-like beta sandwich domain; Region: Cadherin-like; pfam12733 508765009028 Cadherin-like beta sandwich domain; Region: Cadherin-like; pfam12733 508765009029 FOG: Glucan-binding domain (YG repeat) [General function prediction only]; Region: COG5263 508765009030 Cadherin-like beta sandwich domain; Region: Cadherin-like; pfam12733 508765009031 Putative cell wall binding repeat; Region: CW_binding_1; pfam01473 508765009032 Cadherin-like beta sandwich domain; Region: Cadherin-like; pfam12733 508765009033 FOG: Glucan-binding domain (YG repeat) [General function prediction only]; Region: COG5263 508765009034 Putative cell wall binding repeat; Region: CW_binding_1; pfam01473 508765009035 FOG: Glucan-binding domain (YG repeat) [General function prediction only]; Region: COG5263 508765009036 glucan-binding repeat; Region: glucan_65_rpt; TIGR04035 508765009037 glucan-binding repeat; Region: glucan_65_rpt; TIGR04035 508765009038 glucan-binding repeat; Region: glucan_65_rpt; TIGR04035 508765009039 FOG: Glucan-binding domain (YG repeat) [General function prediction only]; Region: COG5263 508765009040 FOG: Glucan-binding domain (YG repeat) [General function prediction only]; Region: COG5263 508765009041 Putative cell wall binding repeat; Region: CW_binding_1; pfam01473 508765009042 Putative cell wall binding repeat; Region: CW_binding_1; pfam01473 508765009043 Cadherin-like beta sandwich domain; Region: Cadherin-like; pfam12733 508765009044 Cadherin-like beta sandwich domain; Region: Cadherin-like; pfam12733 508765009045 Cadherin-like beta sandwich domain; Region: Cadherin-like; pfam12733 508765009046 FOG: Glucan-binding domain (YG repeat) [General function prediction only]; Region: COG5263 508765009047 Putative cell wall binding repeat; Region: CW_binding_1; pfam01473 508765009048 Cadherin-like beta sandwich domain; Region: Cadherin-like; pfam12733 508765009049 Cadherin-like beta sandwich domain; Region: Cadherin-like; pfam12733 508765009050 FOG: Glucan-binding domain (YG repeat) [General function prediction only]; Region: COG5263 508765009051 middle domain of the stomatal closure-related actin binding protein1; Region: SCAB1_middle; cd11675 508765009052 PH domain interface [polypeptide binding]; other site 508765009053 glucan-binding repeat; Region: glucan_65_rpt; TIGR04035 508765009054 Putative cell wall binding repeat; Region: CW_binding_1; pfam01473 508765009055 FOG: Glucan-binding domain (YG repeat) [General function prediction only]; Region: COG5263 508765009056 Putative cell wall binding repeat; Region: CW_binding_1; pfam01473 508765009057 Catalytic NodB homology domain of the carbohydrate esterase 4 superfamily; Region: CE4_SF; cl15692 508765009058 Uncharacterized protein conserved in bacteria (DUF2334); Region: DUF2334; pfam10096 508765009059 Predicted metalloendopeptidase [Posttranslational modification, protein turnover, chaperones]; Region: PepO; COG3590 508765009060 Peptidase family M13 includes neprilysin, endothelin-converting enzyme I; Region: M13; cd08662 508765009061 active site 508765009062 Zn binding site [ion binding]; other site 508765009063 N-terminal phage replisome organiser (Phage_rep_org_N); Region: Phage_rep_org_N; pfam09681 508765009064 Glycosyltransferases involved in cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WcaA; COG0463 508765009065 Glycosyl transferase family 2; Region: Glycos_transf_2; pfam00535 508765009066 active site 508765009067 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394 508765009068 ATP-grasp domain; Region: ATP-grasp_4; pfam13535 508765009069 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 508765009070 Nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: WcaG; COG0451 508765009071 NAD(P) binding site [chemical binding]; other site 508765009072 active site 508765009073 Bacterial DPM1_like enzymes are related to eukaryotic DPM1; Region: DPM1_like_bac; cd04187 508765009074 Ligand binding site; other site 508765009075 Putative Catalytic site; other site 508765009076 DXD motif; other site 508765009077 Predicted pyridoxal phosphate-dependent enzyme apparently involved in regulation of cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WecE; COG0399 508765009078 3-amino-5-hydroxybenzoic acid synthase family (AHBA_syn). AHBA_syn family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The members of this CD are involved in various biosynthetic pathways for secondary...; Region: AHBA_syn; cd00616 508765009079 inhibitor-cofactor binding pocket; inhibition site 508765009080 pyridoxal 5'-phosphate binding site [chemical binding]; other site 508765009081 catalytic residue [active] 508765009082 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 508765009083 Myxococcus xanthus RfbC like proteins are required for O-antigen biosynthesis; Region: GT2_RfbC_Mx_like; cd04184 508765009084 Probable Catalytic site; other site 508765009085 metal-binding site 508765009086 Subfamily of Glycosyltransferase Family GT2 of unknown function; Region: GT_2_like_c; cd04186 508765009087 Probable Catalytic site; other site 508765009088 Glycosyltransferase like family; Region: Glyco_tranf_2_5; pfam13712 508765009089 metal-binding site 508765009090 ABC-type polysaccharide/polyol phosphate transport system, ATPase component [Carbohydrate transport and metabolism / Cell envelope biogenesis, outer membrane]; Region: TagH; COG1134 508765009091 ATP-binding cassette component of polysaccharide transport system; Region: ABC_KpsT_Wzt; cd03220 508765009092 Walker A/P-loop; other site 508765009093 ATP binding site [chemical binding]; other site 508765009094 Q-loop/lid; other site 508765009095 ABC transporter signature motif; other site 508765009096 Walker B; other site 508765009097 D-loop; other site 508765009098 H-loop/switch region; other site 508765009099 C-Terminal domain of O-antigenic polysaccharide transporter protein Wzt and related proteins; Region: Wzt_C-like; cd10147 508765009100 putative carbohydrate binding site [chemical binding]; other site 508765009101 ABC-type polysaccharide/polyol phosphate export systems, permease component [Carbohydrate transport and metabolism / Cell envelope biogenesis, outer membrane]; Region: TagG; COG1682 508765009102 ABC-2 type transporter; Region: ABC2_membrane; pfam01061 508765009103 dTDP-6-deoxy-L-lyxo-4-hexulose reductase and related proteins, extended (e) SDRs; Region: dTDP_HR_like_SDR_e; cd05254 508765009104 RmlD substrate binding domain; Region: RmlD_sub_bind; pfam04321 508765009105 NADP binding site [chemical binding]; other site 508765009106 active site 508765009107 putative substrate binding site [chemical binding]; other site 508765009108 Glycosyltransferases involved in cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WcaA; COG0463 508765009109 Subfamily of Glycosyltransferase Family GT2 of unknown function; Region: GT_2_like_d; cd04196 508765009110 Probable Catalytic site; other site 508765009111 dTDP-D-glucose 4,6-dehydratase [Cell envelope biogenesis, outer membrane]; Region: RfbB; COG1088 508765009112 dTDP-D-glucose 4,6-dehydratase, extended (e) SDRs; Region: dTDP_GD_SDR_e; cd05246 508765009113 NAD binding site [chemical binding]; other site 508765009114 substrate binding site [chemical binding]; other site 508765009115 homodimer interface [polypeptide binding]; other site 508765009116 active site 508765009117 dTDP-4-dehydrorhamnose 3,5-epimerase; Region: dTDP_sugar_isom; pfam00908 508765009118 G1P_TT_short is the short form of glucose-1-phosphate thymidylyltransferase; Region: G1P_TT_short; cd02538 508765009119 glucose-1-phosphate thymidylyltransferase, short form; Region: rmlA; TIGR01207 508765009120 substrate binding site; other site 508765009121 tetramer interface; other site 508765009122 Undecaprenyl-phosphate glucose phosphotransferase; Region: WcaJ_sugtrans; TIGR03023 508765009123 Bacterial sugar transferase; Region: Bac_transf; pfam02397 508765009124 O-Antigen ligase; Region: Wzy_C; cl04850 508765009125 O-Antigen ligase; Region: Wzy_C; pfam04932 508765009126 Protein of unknown function DUF86; Region: DUF86; cl01031 508765009127 FOG: Glucan-binding domain (YG repeat) [General function prediction only]; Region: COG5263 508765009128 Putative cell wall binding repeat; Region: CW_binding_1; pfam01473 508765009129 glucan-binding repeat; Region: glucan_65_rpt; TIGR04035 508765009130 glucan-binding repeat; Region: glucan_65_rpt; TIGR04035 508765009131 Putative cell wall binding repeat; Region: CW_binding_1; pfam01473 508765009132 Putative cell wall binding repeat; Region: CW_binding_1; pfam01473 508765009133 LETM1-like protein; Region: LETM1; pfam07766 508765009134 FOG: Glucan-binding domain (YG repeat) [General function prediction only]; Region: COG5263 508765009135 glucan-binding repeat; Region: glucan_65_rpt; TIGR04035 508765009136 Predicted hydrolase (metallo-beta-lactamase superfamily) [General function prediction only]; Region: ComEC; COG2333 508765009137 Metallo-beta-lactamase superfamily; Region: Lactamase_B; smart00849 508765009138 putative L-xylulose 5-phosphate 3-epimerase; Reviewed; Region: PRK13210 508765009139 AP endonuclease family 2; These endonucleases play a role in DNA repair. Cleave phosphodiester bonds at apurinic or apyrimidinic sites; the alignment also contains hexulose-6-phosphate isomerases, enzymes that catalyze the epimerization of...; Region: AP2Ec; cl12060 508765009140 AP (apurinic/apyrimidinic) site pocket; other site 508765009141 DNA interaction; other site 508765009142 Metal-binding active site; metal-binding site 508765009143 L-ribulose-5-phosphate 4-epimerase; Reviewed; Region: araD; PRK08193 508765009144 Class II Aldolase and Adducin head (N-terminal) domain. Aldolases are ubiquitous enzymes catalyzing central steps of carbohydrate metabolism. Based on enzymatic mechanisms, this superfamily has been divided into two distinct classes (Class I and II); Region: Aldolase_II; cd00398 508765009145 intersubunit interface [polypeptide binding]; other site 508765009146 active site 508765009147 Zn2+ binding site [ion binding]; other site 508765009148 PTS_IIB_ascorbate: subunit IIB of enzyme II (EII) of the L-ascorbate-specific phosphoenolpyruvate:carbohydrate phosphotransferase system (PTS). In this system, EII is an L-ascorbate-specific permease with two cytoplasmic subunits (IIA and IIB) and a...; Region: PTS_IIB_ascorbate; cd05563 508765009149 active site 508765009150 P-loop; other site 508765009151 phosphorylation site [posttranslational modification] 508765009152 PTS system ascorbate-specific transporter subunit IIC; Reviewed; Region: PRK12997 508765009153 PTS_IIA, PTS system, fructose/mannitol specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_fru; cd00211 508765009154 active site 508765009155 phosphorylation site [posttranslational modification] 508765009156 putative L-ascorbate 6-phosphate lactonase; Provisional; Region: PRK11709 508765009157 Predicted Zn-dependent hydrolases of the beta-lactamase fold [General function prediction only]; Region: COG2220 508765009158 Transcriptional regulators of sugar metabolism [Transcription / Carbohydrate transport and metabolism]; Region: GlpR; COG1349 508765009159 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 508765009160 putative DNA binding site [nucleotide binding]; other site 508765009161 putative Zn2+ binding site [ion binding]; other site 508765009162 DeoR C terminal sensor domain; Region: DeoRC; pfam00455 508765009163 M18 Peptidase Aspartyl aminopeptidase; Region: M18_DAP; cd05658 508765009164 Aminopeptidase I zinc metalloprotease (M18); Region: Peptidase_M18; pfam02127 508765009165 active site 508765009166 metal binding site [ion binding]; metal-binding site 508765009167 Predicted Co/Zn/Cd cation transporters [Inorganic ion transport and metabolism]; Region: MMT1; COG0053 508765009168 Cation efflux family; Region: Cation_efflux; pfam01545 508765009169 Thiamine pyrophosphate-requiring enzymes [acetolactate synthase, pyruvate dehydrogenase (cytochrome), glyoxylate carboligase, phosphonopyruvate decarboxylase] [Amino acid transport and metabolism / Coenzyme metabolism]; Region: IlvB; COG0028 508765009170 Pyrimidine (PYR) binding domain of POX and related proteins; Region: TPP_PYR_POX_like; cd07035 508765009171 PYR/PP interface [polypeptide binding]; other site 508765009172 dimer interface [polypeptide binding]; other site 508765009173 TPP binding site [chemical binding]; other site 508765009174 Thiamine pyrophosphate enzyme, central domain; Region: TPP_enzyme_M; pfam00205 508765009175 Thiamine pyrophosphate (TPP) enzyme family, TPP-binding module; found in many key metabolic enzymes which use TPP (also known as thiamine diphosphate) as a cofactor. These enzymes include, among others, the E1 components of the pyruvate, the acetoin and...; Region: TPP_enzymes; cd00568 508765009176 TPP-binding site [chemical binding]; other site 508765009177 Protein of unknown function (DUF2628); Region: DUF2628; pfam10947 508765009178 Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer); Region: MA; smart00283 508765009179 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 508765009180 dimer interface [polypeptide binding]; other site 508765009181 putative CheW interface [polypeptide binding]; other site 508765009182 ABC-type polar amino acid transport system, ATPase component [Amino acid transport and metabolism]; Region: GlnQ; COG1126 508765009183 ATP-binding cassette domain of the histidine and glutamine transporters; Region: ABC_HisP_GlnQ; cd03262 508765009184 Walker A/P-loop; other site 508765009185 ATP binding site [chemical binding]; other site 508765009186 Q-loop/lid; other site 508765009187 ABC transporter signature motif; other site 508765009188 Walker B; other site 508765009189 D-loop; other site 508765009190 H-loop/switch region; other site 508765009191 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097 508765009192 ABC-type arginine transport system, permease component [Amino acid transport and metabolism]; Region: ArtQ; COG4215 508765009193 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 508765009194 dimer interface [polypeptide binding]; other site 508765009195 conserved gate region; other site 508765009196 putative PBP binding loops; other site 508765009197 ABC-ATPase subunit interface; other site 508765009198 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 508765009199 Bacterial extracellular solute-binding proteins, family 3; Region: SBP_bac_3; pfam00497 508765009200 substrate binding pocket [chemical binding]; other site 508765009201 membrane-bound complex binding site; other site 508765009202 hinge residues; other site 508765009203 Superfamily I DNA and RNA helicases [General function prediction only]; Region: COG3973 508765009204 Part of AAA domain; Region: AAA_19; pfam13245 508765009205 Family description; Region: UvrD_C_2; pfam13538 508765009206 FtsH Extracellular; Region: FtsH_ext; pfam06480 508765009207 ATP-dependent metalloprotease FtsH; Region: FtsH_fam; TIGR01241 508765009208 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 508765009209 Walker A motif; other site 508765009210 ATP binding site [chemical binding]; other site 508765009211 Walker B motif; other site 508765009212 arginine finger; other site 508765009213 Peptidase family M41; Region: Peptidase_M41; pfam01434 508765009214 Protein of unknown function (DUF3006); Region: DUF3006; pfam11213 508765009215 signal peptidase I, bacterial type; Region: sigpep_I_bact; TIGR02227 508765009216 The S26 Type I signal peptidase (SPase; LepB; leader peptidase B; leader peptidase I; EC 3.4.21.89) family members are essential membrane-bound serine proteases that function to cleave the amino-terminal signal peptide extension from proteins that are...; Region: S26_SPase_I; cd06530 508765009217 Catalytic site [active] 508765009218 signal peptidase I, bacterial type; Region: sigpep_I_bact; TIGR02227 508765009219 The S26 Type I signal peptidase (SPase; LepB; leader peptidase B; leader peptidase I; EC 3.4.21.89) family members are essential membrane-bound serine proteases that function to cleave the amino-terminal signal peptide extension from proteins that are...; Region: S26_SPase_I; cd06530 508765009220 Catalytic site [active] 508765009221 diaminopimelate decarboxylase; Region: lysA; TIGR01048 508765009222 Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzyme Diaminopimelate Decarboxylase; Region: PLPDE_III_DapDC; cd06828 508765009223 active site 508765009224 pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site 508765009225 substrate binding site [chemical binding]; other site 508765009226 catalytic residues [active] 508765009227 dimer interface [polypeptide binding]; other site 508765009228 Lysine riboswitch 508765009229 TIM barrel proteins share a structurally conserved phosphate binding motif and in general share an eight beta/alpha closed barrel structure. Specific for this family is the conserved phosphate binding site at the edges of strands 7 and 8. The phosphate...; Region: TIM_phosphate_binding; cl17186 508765009230 Peptidoglycan recognition proteins (PGRPs) are pattern recognition receptors that bind, and in certain cases, hydrolyze peptidoglycans (PGNs) of bacterial cell walls. PGRPs have been divided into three classes: short PGRPs (PGRP-S), that are small (20...; Region: PGRP; cd06583 508765009231 amidase catalytic site [active] 508765009232 Zn binding residues [ion binding]; other site 508765009233 substrate binding site [chemical binding]; other site 508765009234 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 508765009235 dimerization interface [polypeptide binding]; other site 508765009236 Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer); Region: MA; smart00283 508765009237 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 508765009238 dimer interface [polypeptide binding]; other site 508765009239 putative CheW interface [polypeptide binding]; other site 508765009240 aspartate aminotransferase; Provisional; Region: PRK06836 508765009241 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 508765009242 pyridoxal 5'-phosphate binding site [chemical binding]; other site 508765009243 homodimer interface [polypeptide binding]; other site 508765009244 catalytic residue [active] 508765009245 Von Willebrand factor type A (vWA) domain was originally found in the blood coagulation protein von Willebrand factor (vWF). Typically, the vWA domain is made up of approximately 200 amino acid residues folded into a classic a/b para-rossmann type of...; Region: vWFA; cd00198 508765009246 metal ion-dependent adhesion site (MIDAS); other site 508765009247 Fimbrial assembly protein (PilN); Region: PilN; pfam05137 508765009248 Tfp pilus assembly protein, ATPase PilM [Cell motility and secretion / Intracellular trafficking and secretion]; Region: PilM; COG4972 508765009249 Type II secretory pathway, component PulF [Cell motility and secretion / Intracellular trafficking and secretion]; Region: PulF; COG1459 508765009250 Type II secretion system (T2SS), protein F; Region: T2SF; pfam00482 508765009251 Type II secretion system (T2SS), protein F; Region: T2SF; pfam00482 508765009252 Type II secretory pathway, ATPase PulE/Tfp pilus assembly pathway, ATPase PilB [Cell motility and secretion / Intracellular trafficking and secretion]; Region: PulE; COG2804 508765009253 Type II secretion system (T2SS), protein E, N-terminal domain; Region: T2SE_Nter; pfam05157 508765009254 PulE/GspE The type II secretory pathway is the main terminal branch of the general secretory pathway (GSP). It is responsible for the export the majority of Gram-negative bacterial exoenzymes and toxins. PulE is a cytoplasmic protein of the GSP, which...; Region: PulE-GspE; cd01129 508765009255 Walker A motif; other site 508765009256 ATP binding site [chemical binding]; other site 508765009257 Walker B motif; other site 508765009258 Type II secretory pathway, prepilin signal peptidase PulO and related peptidases [Cell motility and secretion / Posttranslational modification, protein turnover, chaperones / Intracellular trafficking and secretion]; Region: PulO; COG1989 508765009259 Bacterial Peptidase A24 N-terminal domain; Region: DiS_P_DiS; pfam06750 508765009260 ABC-2 family transporter protein; Region: ABC2_membrane_5; pfam13346 508765009261 ABC-type multidrug transport system, ATPase component [Defense mechanisms]; Region: CcmA; COG1131 508765009262 ATP-binding cassette domain of the drug resistance transporter and related proteins, subfamily A; Region: ABC_DR_subfamily_A; cd03230 508765009263 Walker A/P-loop; other site 508765009264 ATP binding site [chemical binding]; other site 508765009265 Q-loop/lid; other site 508765009266 ABC transporter signature motif; other site 508765009267 Walker B; other site 508765009268 D-loop; other site 508765009269 H-loop/switch region; other site 508765009270 Predicted transcriptional regulators [Transcription]; Region: COG1725 508765009271 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 508765009272 DNA-binding site [nucleotide binding]; DNA binding site 508765009273 Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer); Region: MA; smart00283 508765009274 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 508765009275 dimer interface [polypeptide binding]; other site 508765009276 putative CheW interface [polypeptide binding]; other site 508765009277 ABC transporter, phosphonate, periplasmic substrate-binding protein; Region: Phosphonate-bd; pfam12974 508765009278 TRAP transporter solute receptor, TAXI family; Region: TRAP_TAXI; TIGR02122 508765009279 Heavy-metal-associated domain (HMA) is a conserved domain of approximately 30 amino acid residues found in a number of proteins that transport or detoxify heavy metals, for example, the CPx-type heavy metal ATPases and copper chaperones. HMA domain...; Region: HMA; cd00371 508765009280 metal-binding site [ion binding] 508765009281 Cation transport ATPase [Inorganic ion transport and metabolism]; Region: ZntA; COG2217 508765009282 Heavy-metal-associated domain (HMA) is a conserved domain of approximately 30 amino acid residues found in a number of proteins that transport or detoxify heavy metals, for example, the CPx-type heavy metal ATPases and copper chaperones. HMA domain...; Region: HMA; cd00371 508765009283 metal-binding site [ion binding] 508765009284 Cation transport ATPase [Inorganic ion transport and metabolism]; Region: ZntA; COG2217 508765009285 Heavy-metal-associated domain (HMA) is a conserved domain of approximately 30 amino acid residues found in a number of proteins that transport or detoxify heavy metals, for example, the CPx-type heavy metal ATPases and copper chaperones. HMA domain...; Region: HMA; cd00371 508765009286 metal-binding site [ion binding] 508765009287 E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122 508765009288 Soluble P-type ATPase [General function prediction only]; Region: COG4087 508765009289 Uncharacterized family 2; belongs to a superfamily containing transcriptional regulators CsoR (copper-sensitive operon repressor), RcnR, and FrmR, and related domains; this family was previously known as part of DUF156; Region: CsoR-like_DUF156_2; cd10159 508765009290 putative homodimer interface [polypeptide binding]; other site 508765009291 putative homotetramer interface [polypeptide binding]; other site 508765009292 putative allosteric switch controlling residues; other site 508765009293 putative metal binding site [ion binding]; other site 508765009294 putative homodimer-homodimer interface [polypeptide binding]; other site 508765009295 Metal-dependent amidase/aminoacylase/carboxypeptidase [General function prediction only]; Region: AbgB; COG1473 508765009296 M20 Peptidase Aminoacyclase-1 YxeP-like proteins, including YxeP, YtnL, YjiB and HipO2; Region: M20_Acy1_YxeP_like; cd05669 508765009297 metal binding site [ion binding]; metal-binding site 508765009298 dimer interface [polypeptide binding]; other site 508765009299 Peroxiredoxin [Posttranslational modification, protein turnover, chaperones]; Region: AhpC; COG0450 508765009300 Peroxiredoxin (PRX) family, Bacterioferritin comigratory protein (BCP) subfamily; composed of thioredoxin-dependent thiol peroxidases, widely expressed in pathogenic bacteria, that protect cells against toxicity from reactive oxygen species by reducing...; Region: PRX_BCP; cd03017 508765009301 catalytic triad [active] 508765009302 Predicted amidohydrolase [General function prediction only]; Region: COG0388 508765009303 Uncharacterized subgroup of the nitrilase superfamily (putative class 13 nitrilases); Region: nitrilase_5; cd07583 508765009304 putative active site [active] 508765009305 catalytic triad [active] 508765009306 putative dimer interface [polypeptide binding]; other site 508765009307 Predicted acetyltransferases and hydrolases with the alpha/beta hydrolase fold [General function prediction only]; Region: LipA; COG1075 508765009308 Predicted acetyltransferases and hydrolases with the alpha/beta hydrolase fold [General function prediction only]; Region: LipA; COG1075 508765009309 Cysteine synthase [Amino acid transport and metabolism]; Region: CysK; COG0031 508765009310 CBS_like: This subgroup includes Cystathionine beta-synthase (CBS) and Cysteine synthase. CBS is a unique heme-containing enzyme that catalyzes a pyridoxal 5'-phosphate (PLP)-dependent condensation of serine and homocysteine to give cystathionine; Region: CBS_like; cd01561 508765009311 dimer interface [polypeptide binding]; other site 508765009312 pyridoxal 5'-phosphate binding site [chemical binding]; other site 508765009313 catalytic residue [active] 508765009314 S-ribosylhomocysteinase; Provisional; Region: PRK02260 508765009315 cystathionine beta-lyase; Provisional; Region: PRK07671 508765009316 CGS_like: Cystathionine gamma-synthase is a PLP dependent enzyme and catalyzes the committed step of methionine biosynthesis. This pathway is unique to microorganisms and plants, rendering the enzyme an attractive target for the development of...; Region: CGS_like; cd00614 508765009317 homodimer interface [polypeptide binding]; other site 508765009318 substrate-cofactor binding pocket; other site 508765009319 pyridoxal 5'-phosphate binding site [chemical binding]; other site 508765009320 catalytic residue [active] 508765009321 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 508765009322 S-adenosylmethionine binding site [chemical binding]; other site 508765009323 T-box leader 508765009324 16S rRNA uridine-516 pseudouridylate synthase and related pseudouridylate synthases [Translation, ribosomal structure and biogenesis]; Region: RsuA; COG1187 508765009325 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 508765009326 RNA binding surface [nucleotide binding]; other site 508765009327 Pseudouridine synthase, Escherichia coli RsuA like; Region: PseudoU_synth_RsuA; cd02553 508765009328 active site 508765009329 uracil binding [chemical binding]; other site 508765009330 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 508765009331 salt bridge; other site 508765009332 non-specific DNA binding site [nucleotide binding]; other site 508765009333 sequence-specific DNA binding site [nucleotide binding]; other site 508765009334 Protein of unknown function (DUF3955); Region: DUF3955; pfam13127 508765009335 Aerobic-type carbon monoxide dehydrogenase, middle subunit CoxM/CutM homologs [Energy production and conversion]; Region: CoxM; COG1319 508765009336 CO dehydrogenase flavoprotein C-terminal domain; Region: CO_deh_flav_C; smart01092 508765009337 Aerobic-type carbon monoxide dehydrogenase, small subunit CoxS/CutS homologs [Energy production and conversion]; Region: CoxS; COG2080 508765009338 [2Fe-2S] binding domain; Region: Fer2_2; pfam01799 508765009339 Aerobic-type carbon monoxide dehydrogenase, large subunit CoxL/CutL homologs [Energy production and conversion]; Region: CoxL; COG1529 508765009340 Aldehyde oxidase and xanthine dehydrogenase, a/b hammerhead domain; Region: Ald_Xan_dh_C; smart01008 508765009341 Molybdopterin-binding domain of aldehyde dehydrogenase; Region: Ald_Xan_dh_C2; pfam02738 508765009342 GT_2_like_f is a subfamily of the glycosyltransferase family 2 (GT-2) with unknown function; Region: GT_2_like_f; cd04182 508765009343 Ligand binding site; other site 508765009344 metal-binding site 508765009345 N-terminal domain of molybdenum-binding protein [General function prediction only]; Region: ModE; cl17549 508765009346 TRAM domain; Region: TRAM; cl01282 508765009347 SAM-dependent methyltransferases related to tRNA (uracil-5-)-methyltransferase [Translation, ribosomal structure and biogenesis]; Region: TrmA; COG2265 508765009348 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 508765009349 S-adenosylmethionine binding site [chemical binding]; other site 508765009350 Domain of Unknown Function (DUF1540); Region: DUF1540; pfam07561 508765009351 Escherichia coli xylulokinase-like D-xylulose kinases; a subgroup of the FGGY family of carbohydrate kinases; Region: FGGY_D-XK_EcXK-like; cd07808 508765009352 N- and C-terminal domain interface [polypeptide binding]; other site 508765009353 D-xylulose kinase; Region: XylB; TIGR01312 508765009354 active site 508765009355 MgATP binding site [chemical binding]; other site 508765009356 catalytic site [active] 508765009357 metal binding site [ion binding]; metal-binding site 508765009358 xylulose binding site [chemical binding]; other site 508765009359 homodimer interface [polypeptide binding]; other site 508765009360 Threonine dehydrogenase and related Zn-dependent dehydrogenases [Amino acid transport and metabolism / General function prediction only]; Region: Tdh; COG1063 508765009361 Sorbitol dehydrogenase; Region: sorbitol_DH; cd05285 508765009362 inhibitor binding site; inhibition site 508765009363 catalytic Zn binding site [ion binding]; other site 508765009364 structural Zn binding site [ion binding]; other site 508765009365 NADP binding site [chemical binding]; other site 508765009366 tetramer interface [polypeptide binding]; other site 508765009367 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 508765009368 putative DNA binding site [nucleotide binding]; other site 508765009369 dimerization interface [polypeptide binding]; other site 508765009370 putative Zn2+ binding site [ion binding]; other site 508765009371 Transcriptional regulator/sugar kinase [Transcription / Carbohydrate transport and metabolism]; Region: NagC; COG1940 508765009372 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cd00012 508765009373 nucleotide binding site [chemical binding]; other site 508765009374 Pyruvate kinase [Carbohydrate transport and metabolism]; Region: PykF; COG0469 508765009375 Pyruvate kinase (PK): Large allosteric enzyme that regulates glycolysis through binding of the substrate, phosphoenolpyruvate, and one or more allosteric effectors. Like other allosteric enzymes, PK has a high substrate affinity R state and a low...; Region: Pyruvate_Kinase; cl17342 508765009376 domain interfaces; other site 508765009377 active site 508765009378 6-phosphofructokinase; Provisional; Region: PRK03202 508765009379 6-phosphofructokinase; Region: PFKA_ATP; TIGR02482 508765009380 active site 508765009381 ADP/pyrophosphate binding site [chemical binding]; other site 508765009382 dimerization interface [polypeptide binding]; other site 508765009383 allosteric effector site; other site 508765009384 fructose-1,6-bisphosphate binding site; other site 508765009385 DNA polymerase III DnaE; Reviewed; Region: dnaE; PRK06826 508765009386 Polymerase and Histidinol Phosphatase domain of alpha-subunit of bacterial polymerase III DnaE3; Region: PHP_PolIIIA_DnaE3; cd12113 508765009387 active site 508765009388 PHP Thumb interface [polypeptide binding]; other site 508765009389 metal binding site [ion binding]; metal-binding site 508765009390 DnaE_OBF: A subfamily of OB folds corresponding to the C-terminal OB-fold nucleic acid binding domain of Thermus aquaticus and Escherichia coli type C replicative DNA polymerase III alpha subunit (DnaE). The DNA polymerase holoenzyme of E. coli contains...; Region: DnaE_OBF; cd04485 508765009391 generic binding surface II; other site 508765009392 generic binding surface I; other site 508765009393 Stress responsive A/B Barrel Domain; Region: Dabb; smart00886 508765009394 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG1481 508765009395 Sporulation Regulator WhiA N terminal; Region: WhiA_N; pfam10298 508765009396 conserved hypothetical protein, cofD-related; Region: CofD_related; TIGR01826 508765009397 family of mostly uncharacterized proteins similar to B.subtilis YvcK; Region: YvcK_like; cd07187 508765009398 putative substrate binding pocket [chemical binding]; other site 508765009399 dimer interface [polypeptide binding]; other site 508765009400 phosphate binding site [ion binding]; other site 508765009401 glmZ(sRNA)-inactivating NTPase; Provisional; Region: PRK05416 508765009402 shikimate kinase; Provisional; Region: PRK13947 508765009403 UDP-N-acetylenolpyruvoylglucosamine reductase; Provisional; Region: murB; PRK13905 508765009404 FAD binding domain; Region: FAD_binding_4; pfam01565 508765009405 UDP-N-acetylenolpyruvoylglucosamine reductase, C-terminal domain; Region: MurB_C; pfam02873 508765009406 excinuclease ABC subunit C; Validated; Region: uvrC; PRK00558 508765009407 Catalytic GIY-YIG domain of nucleotide excision repair endonucleases UvrC, Cho, and similar proteins; Region: GIY-YIG_UvrC_Cho; cd10434 508765009408 GIY-YIG motif/motif A; other site 508765009409 active site 508765009410 catalytic site [active] 508765009411 putative DNA binding site [nucleotide binding]; other site 508765009412 metal binding site [ion binding]; metal-binding site 508765009413 UvrB/uvrC motif; Region: UVR; pfam02151 508765009414 UvrC Helix-hairpin-helix N-terminal; Region: UvrC_HhH_N; pfam08459 508765009415 Penicillin-binding Protein dimerisation domain; Region: PBP_dimer; pfam03717 508765009416 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; pfam00905 508765009417 Bacterial cell division membrane protein [Cell division and chromosome partitioning]; Region: FtsW; COG0772 508765009418 Forkhead associated domain (FHA); found in eukaryotic and prokaryotic proteins. Putative nuclear signalling domain. FHA domains may bind phosphothreonine, phosphoserine and sometimes phosphotyrosine. In eukaryotes, many FHA domain-containing proteins...; Region: FHA; cd00060 508765009419 FOG: FHA domain [Signal transduction mechanisms]; Region: COG1716 508765009420 phosphopeptide binding site; other site 508765009421 excinuclease ABC subunit A; Reviewed; Region: uvrA; PRK00349 508765009422 ATP-binding cassette domain I of the excision repair protein UvrA; Region: ABC_UvrA_I; cd03270 508765009423 ATP-binding cassette domain I of the excision repair protein UvrA; Region: ABC_UvrA_I; cd03270 508765009424 ATP-binding cassette domain II of the excision repair protein UvrA; Region: ABC_UvrA_II; cd03271 508765009425 excinuclease ABC subunit B; Provisional; Region: PRK05298 508765009426 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 508765009427 ATP binding site [chemical binding]; other site 508765009428 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 508765009429 nucleotide binding region [chemical binding]; other site 508765009430 ATP-binding site [chemical binding]; other site 508765009431 Ultra-violet resistance protein B; Region: UvrB; pfam12344 508765009432 UvrB/uvrC motif; Region: UVR; pfam02151 508765009433 PDZ domain of tryspin-like serine proteases, such as DegP/HtrA, which are oligomeric proteins involved in heat-shock response, chaperone function, and apoptosis. May be responsible for substrate recognition and/or binding, as most PDZ domains bind...; Region: PDZ_serine_protease; cd00987 508765009434 protein binding site [polypeptide binding]; other site 508765009435 Periplasmic protease [Cell envelope biogenesis, outer membrane]; Region: Prc; COG0793 508765009436 C-terminal processing peptidase family S41; Region: Peptidase_S41; cl02526 508765009437 PDZ domain of C-terminal processing-, tail-specific-, and tricorn proteases, which function in posttranslational protein processing, maturation, and disassembly or degradation, in Bacteria, Archaea, and plant chloroplasts. May be responsible for...; Region: PDZ_CTP_protease; cd00988 508765009438 protein binding site [polypeptide binding]; other site 508765009439 C-terminal processing peptidase; serine protease family S41; Region: Peptidase_S41_CPP; cd07560 508765009440 Catalytic dyad [active] 508765009441 Cell division protein [Cell division and chromosome partitioning]; Region: FtsX; COG2177 508765009442 cell division ABC transporter subunit FtsX; Provisional; Region: ftsX; PRK11026 508765009443 Predicted ATPase involved in cell division [Cell division and chromosome partitioning]; Region: FtsE; COG2884 508765009444 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 508765009445 Walker A/P-loop; other site 508765009446 ATP binding site [chemical binding]; other site 508765009447 Q-loop/lid; other site 508765009448 ABC transporter signature motif; other site 508765009449 Walker B; other site 508765009450 D-loop; other site 508765009451 H-loop/switch region; other site 508765009452 Uncharacterized conserved protein [Function unknown]; Region: COG1284 508765009453 Uncharacterized BCR, YitT family COG1284; Region: DUF161; pfam02588 508765009454 Uncharacterized protein conserved in bacteria (DUF2179); Region: DUF2179; pfam10035 508765009455 Transketolase, C-terminal subunit [Carbohydrate transport and metabolism]; Region: COG3958 508765009456 Pyrimidine (PYR) binding domain of 1-deoxy-D-xylulose-5-phosphate synthase (DXS), transketolase (TK), and related proteins; Region: TPP_PYR_DXS_TK_like; cd07033 508765009457 PYR/PP interface [polypeptide binding]; other site 508765009458 dimer interface [polypeptide binding]; other site 508765009459 TPP binding site [chemical binding]; other site 508765009460 Transketolase, C-terminal domain; Region: Transketolase_C; pfam02780 508765009461 transketolase; Reviewed; Region: PRK05899 508765009462 Thiamine pyrophosphate (TPP) family, Transketolase (TK) subfamily, TPP-binding module; TK catalyzes the transfer of a two-carbon unit from ketose phosphates to aldose phosphates. In heterotrophic organisms, TK provides a link between glycolysis and the...; Region: TPP_TK; cd02012 508765009463 TPP-binding site [chemical binding]; other site 508765009464 dimer interface [polypeptide binding]; other site 508765009465 PTS system mannose/fructose/sorbose family IID component; Region: EIID-AGA; pfam03613 508765009466 PTS system sorbose-specific iic component; Region: EII-Sor; pfam03609 508765009467 PTS system sorbose subfamily IIB component; Region: PTSIIB_sorb; pfam03830 508765009468 active site 508765009469 phosphorylation site [posttranslational modification] 508765009470 PTS_IIA, PTS system, mannose/sorbose specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIA_man; cd00006 508765009471 active pocket/dimerization site; other site 508765009472 active site 508765009473 phosphorylation site [posttranslational modification] 508765009474 Transcriptional regulators containing an AAA-type ATPase domain and a DNA-binding domain [Transcription / Signal transduction mechanisms]; Region: PspF; COG1221 508765009475 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 508765009476 Walker A motif; other site 508765009477 ATP binding site [chemical binding]; other site 508765009478 Walker B motif; other site 508765009479 arginine finger; other site 508765009480 PRD domain; Region: PRD; pfam00874 508765009481 PTS_IIA, PTS system, mannose/sorbose specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIA_man; cd00006 508765009482 active pocket/dimerization site; other site 508765009483 active site 508765009484 phosphorylation site [posttranslational modification] 508765009485 PRD domain; Region: PRD; pfam00874 508765009486 PemK-like protein; Region: PemK; pfam02452 508765009487 YjeF-related protein N-terminus; Region: YjeF_N; pfam03853 508765009488 B.subtilis YXKO protein of unknown function and related proteins. Based on the conservation of the ATP binding site, the substrate binding site and the Mg2+binding site and structural homology this group is a member of the ribokinase-like superfamily; Region: YXKO-related; cd01171 508765009489 putative substrate binding site [chemical binding]; other site 508765009490 putative ATP binding site [chemical binding]; other site 508765009491 4'-phosphopantetheinyl transferase; Provisional; Region: acpS; PRK00070 508765009492 Single-stranded DNA-binding protein [DNA replication, recombination, and repair]; Region: Ssb; COG0629 508765009493 SSB_OBF: A subfamily of OB folds similar to the OB fold of ssDNA-binding protein (SSB). SSBs bind with high affinity to ssDNA. They bind to and protect ssDNA intermediates during DNA metabolic pathways. All bacterial and eukaryotic SSBs studied to date...; Region: SSB_OBF; cd04496 508765009494 dimer interface [polypeptide binding]; other site 508765009495 ssDNA binding site [nucleotide binding]; other site 508765009496 tetramer (dimer of dimers) interface [polypeptide binding]; other site 508765009497 Virulence factor BrkB; Region: Virul_fac_BrkB; pfam03631 508765009498 UDP-N-acetyl-D-mannosaminuronate dehydrogenase [Cell envelope biogenesis, outer membrane]; Region: WecC; COG0677 508765009499 UDP-glucose/GDP-mannose dehydrogenase family, central domain; Region: UDPG_MGDP_dh; pfam00984 508765009500 UDP-glucose/GDP-mannose dehydrogenase family, UDP binding domain; Region: UDPG_MGDP_dh_C; pfam03720 508765009501 Left-handed parallel beta-Helix (LbetaH or LbH) domain: The alignment contains 5 turns, each containing three imperfect tandem repeats of a hexapeptide repeat motif (X-[STAV]-X-[LIV]-[GAED]-X). Proteins containing hexapeptide repeats are often enzymes...; Region: LbetaH; cl00160 508765009502 putative trimer interface [polypeptide binding]; other site 508765009503 WcxM-like, Left-handed parallel beta-Helix (LbH) N-terminal domain: This group is composed of Xanthomonas campestris WcxM and proteins with similarity to the WcxM N-terminal domain. WcxM is thought to be bifunctional, catalyzing both the isomerization...; Region: LbH_WxcM_N_like; cd03358 508765009504 putative CoA binding site [chemical binding]; other site 508765009505 putative trimer interface [polypeptide binding]; other site 508765009506 putative active site [active] 508765009507 putative substrate binding site [chemical binding]; other site 508765009508 putative CoA binding site [chemical binding]; other site 508765009509 DegT/DnrJ/EryC1/StrS aminotransferase family; Region: DegT_DnrJ_EryC1; pfam01041 508765009510 3-amino-5-hydroxybenzoic acid synthase family (AHBA_syn). AHBA_syn family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The members of this CD are involved in various biosynthetic pathways for secondary...; Region: AHBA_syn; cd00616 508765009511 inhibitor-cofactor binding pocket; inhibition site 508765009512 pyridoxal 5'-phosphate binding site [chemical binding]; other site 508765009513 catalytic residue [active] 508765009514 Domain of unknown function (DUF1836); Region: DUF1836; pfam08876 508765009515 Predicted methyltransferases [General function prediction only]; Region: COG0313 508765009516 Ribosomal RNA small subunit methyltransferase I, also known as rRNA (cytidine-2'-O-)-methyltransferase RsmI; Region: RsmI; cd11648 508765009517 putative SAM binding site [chemical binding]; other site 508765009518 putative homodimer interface [polypeptide binding]; other site 508765009519 Predicted O-methyltransferase [General function prediction only]; Region: COG4123 508765009520 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 508765009521 S-adenosylmethionine binding site [chemical binding]; other site 508765009522 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3883 508765009523 Cell wall-associated hydrolases (invasion-associated proteins) [Cell envelope biogenesis, outer membrane]; Region: Spr; COG0791 508765009524 NlpC/P60 family; Region: NLPC_P60; pfam00877 508765009525 beta-phosphoglucomutase family hydrolase; Region: PGMB-YQAB-SF; TIGR02009 508765009526 haloacid dehalogenase-like hydrolase; Region: HAD; cl17202 508765009527 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 508765009528 motif II; other site 508765009529 peptidylprolyl isomerase; Provisional; Region: prsA; PRK00059 508765009530 PPIC-type PPIASE domain; Region: Rotamase; pfam00639 508765009531 Family 1 of Uracil-DNA glycosylase (UDG) enzymes; Region: UDG_F1; cd10027 508765009532 ligand binding site [chemical binding]; other site 508765009533 active site 508765009534 UGI interface [polypeptide binding]; other site 508765009535 catalytic site [active] 508765009536 Protein of unknown function (DUF3785); Region: DUF3785; pfam12653 508765009537 MogA_MoaB family. Members of this family are involved in biosynthesis of the molybdenum cofactor (MoCF) an essential cofactor of a diverse group of redox enzymes. MoCF biosynthesis is an evolutionarily conserved pathway present in eubacteria, archaea; Region: MogA_MoaB; cd00886 508765009538 MPT binding site; other site 508765009539 trimer interface [polypeptide binding]; other site 508765009540 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3708 508765009541 Predicted transcriptional regulator [Transcription]; Region: COG2378 508765009542 HTH domain; Region: HTH_11; pfam08279 508765009543 WYL domain; Region: WYL; pfam13280 508765009544 NAD-dependent deacetylase; Provisional; Region: PRK00481 508765009545 SIR2 superfamily of proteins includes silent information regulator 2 (Sir2) enzymes which catalyze NAD+-dependent protein/histone deacetylation, where the acetyl group from the lysine epsilon-amino group is transferred to the ADP-ribose moiety of NAD+; Region: SIR2; cl00195 508765009546 lipoyltransferase and lipoate-protein ligase; Region: lipoyltrans; TIGR00545 508765009547 Lipoate-protein ligase A [Coenzyme metabolism]; Region: LplA; COG0095 508765009548 Bacterial lipoate protein ligase C-terminus; Region: Lip_prot_lig_C; pfam10437 508765009549 Pyruvate/2-oxoglutarate dehydrogenase complex, dihydrolipoamide acyltransferase (E2) component, and related enzymes [Energy production and conversion]; Region: AceF; COG0508 508765009550 Lipoyl domain of the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases. 2-oxo acid dehydrogenase multienzyme complexes, like pyruvate dehydrogenase (PDH), 2-oxoglutarate dehydrogenase (OGDH) and branched-chain 2-oxo acid...; Region: lipoyl_domain; cd06849 508765009551 E3 interaction surface; other site 508765009552 lipoyl attachment site [posttranslational modification]; other site 508765009553 dihydrolipoamide dehydrogenase; Region: lipoamide_DH; TIGR01350 508765009554 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450 508765009555 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 508765009556 Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain; Region: Pyr_redox_dim; pfam02852 508765009557 Uncharacterized homolog of gamma-carboxymuconolactone decarboxylase subunit [Function unknown]; Region: COG0599 508765009558 helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347 508765009559 MarR family; Region: MarR_2; pfam12802 508765009560 BFD-like [2Fe-2S] binding domain; Region: Fer2_BFD; pfam04324 508765009561 CAAX protease self-immunity; Region: Abi; pfam02517 508765009562 Competence-damaged protein; Region: CinA; pfam02464 508765009563 Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067 508765009564 catalytic core [active] 508765009565 ROK family protein (putative glucokinase); Region: ROK_glcA_fam; TIGR00744 508765009566 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cd00012 508765009567 nucleotide binding site [chemical binding]; other site 508765009568 Elongation factor G (EF-G) family; Region: EF-G_bact; cd04170 508765009569 elongation factor G; Reviewed; Region: PRK12740 508765009570 G1 box; other site 508765009571 putative GEF interaction site [polypeptide binding]; other site 508765009572 GTP/Mg2+ binding site [chemical binding]; other site 508765009573 Switch I region; other site 508765009574 G2 box; other site 508765009575 G3 box; other site 508765009576 Switch II region; other site 508765009577 G4 box; other site 508765009578 G5 box; other site 508765009579 EFG_mtEFG_II: this subfamily represents the domain II of elongation factor G (EF-G) in bacteria and, the C-terminus of mitochondrial Elongation factor G1 (mtEFG1) and G2 (mtEFG2)_like proteins found in eukaryotes. During the process of peptide synthesis...; Region: EFG_mtEFG_II; cd04088 508765009580 EFG_mtEFG1_IV: domains similar to domain IV of the bacterial translational elongation factor (EF) EF-G. Included in this group is a domain of mitochondrial Elongation factor G1 (mtEFG1) proteins homologous to domain IV of EF-G. Eukaryotic cells harbor 2...; Region: EFG_mtEFG1_IV; cd01434 508765009581 EFG_mtEFG_C: domains similar to the C-terminal domain of the bacterial translational elongation factor (EF) EF-G. Included in this group is the C-terminus of mitochondrial Elongation factor G1 (mtEFG1) and G2 (mtEFG2) proteins. Eukaryotic cells harbor 2...; Region: EFG_mtEFG_C; cd03713 508765009582 Phosphoglycerol transferase and related proteins, alkaline phosphatase superfamily [Cell envelope biogenesis, outer membrane]; Region: MdoB; COG1368 508765009583 Sulfatase; Region: Sulfatase; pfam00884 508765009584 Putative p-aminobenzoyl-glutamate transporter [Coenzyme metabolism]; Region: AbgT; COG2978 508765009585 p-Aminobenzoyl-glutamate transporter family; Region: ydaH; TIGR00819 508765009586 Predicted integral membrane protein [Function unknown]; Region: COG5652 508765009587 glucose-1-phosphate adenylyltransferase, GlgD subunit; Region: glgD; TIGR02092 508765009588 ADP-glucose pyrophosphorylase is involved in the biosynthesis of glycogen or starch; Region: ADP_Glucose_PP; cd02508 508765009589 ligand binding site; other site 508765009590 oligomer interface; other site 508765009591 Glucose-1-phosphate adenylyltransferase, C-terminal Left-handed parallel beta helix (LbH) domain: Glucose-1-phosphate adenylyltransferase is also known as ADP-glucose synthase or ADP-glucose pyrophosphorylase. It catalyzes the first committed and...; Region: LbH_G1P_AT_C; cd04651 508765009592 dimer interface [polypeptide binding]; other site 508765009593 N-terminal domain interface [polypeptide binding]; other site 508765009594 sulfate 1 binding site; other site 508765009595 glucose-1-phosphate adenylyltransferase; Provisional; Region: glgC; PRK05293 508765009596 ADP-glucose pyrophosphorylase is involved in the biosynthesis of glycogen or starch; Region: ADP_Glucose_PP; cd02508 508765009597 ligand binding site; other site 508765009598 oligomer interface; other site 508765009599 Glucose-1-phosphate adenylyltransferase, C-terminal Left-handed parallel beta helix (LbH) domain: Glucose-1-phosphate adenylyltransferase is also known as ADP-glucose synthase or ADP-glucose pyrophosphorylase. It catalyzes the first committed and...; Region: LbH_G1P_AT_C; cd04651 508765009600 dimer interface [polypeptide binding]; other site 508765009601 N-terminal domain interface [polypeptide binding]; other site 508765009602 sulfate 1 binding site; other site 508765009603 N-terminal Early set domain associated with the catalytic domain of cyclomaltodextrinase and pullulan-degrading enzymes; Region: E_set_CDase_PDE_N; cd02857 508765009604 homodimer interface [polypeptide binding]; other site 508765009605 Alpha amylase catalytic domain found in cyclomaltodextrinases and related proteins; Region: AmyAc_CMD; cd11338 508765009606 Glycosidases [Carbohydrate transport and metabolism]; Region: AmyA; COG0366 508765009607 active site 508765009608 homodimer interface [polypeptide binding]; other site 508765009609 catalytic site [active] 508765009610 This is a family of oligosaccharide phosphorylases. It includes yeast and mammalian glycogen phosphorylases, plant starch/glucan phosphorylase, as well as the maltodextrin phosphorylases of bacteria. The members of this family catalyze the breakdown of...; Region: GT1_Glycogen_Phosphorylase; cd04300 508765009611 homodimer interface [polypeptide binding]; other site 508765009612 glycogen/starch/alpha-glucan phosphorylases; Region: P_ylase; TIGR02093 508765009613 active site pocket [active] 508765009614 glycogen synthase; Provisional; Region: glgA; PRK00654 508765009615 This family is most closely related to the GT1 family of glycosyltransferases. Glycogen synthase catalyzes the formation and elongation of the alpha-1,4-glucose backbone using ADP-glucose, the second and key step of glycogen biosynthesis. This family...; Region: GT1_Glycogen_synthase_DULL1_like; cd03791 508765009616 ADP-binding pocket [chemical binding]; other site 508765009617 homodimer interface [polypeptide binding]; other site 508765009618 glycogen branching enzyme; Provisional; Region: PRK12313 508765009619 N-terminal Early set domain associated with the catalytic domain of prokaryotic glycogen branching enzyme; Region: E_set_GBE_prok_N; cd02855 508765009620 Alpha amylase catalytic domain found in the Glycogen branching enzyme (also called 1,4-alpha-glucan branching enzyme); Region: AmyAc_Glg_BE; cd11322 508765009621 active site 508765009622 catalytic site [active] 508765009623 Alpha amylase, C-terminal all-beta domain; Region: Alpha-amylase_C; pfam02806 508765009624 Phosphotransferase system IIA components [Carbohydrate transport and metabolism]; Region: NagE; COG2190 508765009625 HPr interaction site; other site 508765009626 glycerol kinase (GK) interaction site [polypeptide binding]; other site 508765009627 active site 508765009628 phosphorylation site [posttranslational modification] 508765009629 PTS system, glucose-specific IIBC component; Region: PTS-II-BC-glcB; TIGR02002 508765009630 Phosphotransferase system IIC components, glucose/maltose/N-acetylglucosamine-specific [Carbohydrate transport and metabolism]; Region: PtsG; COG1263 508765009631 PTS_IIB, PTS system, glucose/sucrose specific IIB subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIB_glc; cd00212 508765009632 active site turn [active] 508765009633 phosphorylation site [posttranslational modification] 508765009634 CAT RNA binding domain; Region: CAT_RBD; smart01061 508765009635 transcriptional antiterminator BglG; Provisional; Region: PRK09772 508765009636 PRD domain; Region: PRD; pfam00874 508765009637 PRD domain; Region: PRD; pfam00874 508765009638 Acetyltransferases, including N-acetylases of ribosomal proteins [Translation, ribosomal structure and biogenesis]; Region: RimL; COG1670 508765009639 Acetyltransferases, including N-acetylases of ribosomal proteins [Translation, ribosomal structure and biogenesis]; Region: RimL; COG1670 508765009640 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl17182 508765009641 Bacterial flagellin N-terminal helical region; Region: Flagellin_N; pfam00669 508765009642 flagellin; Provisional; Region: PRK12804 508765009643 Bacterial flagellin C-terminal helical region; Region: Flagellin_C; pfam00700 508765009644 Global regulator protein family; Region: CsrA; pfam02599 508765009645 Fusaric acid resistance protein-like; Region: FUSC_2; pfam13515 508765009646 Dinucleotide-utilizing enzymes involved in molybdopterin and thiamine biosynthesis family 1 [Coenzyme metabolism]; Region: COG1179 508765009647 Family of activating enzymes (E1) of ubiquitin-like proteins related to the E.coli hypothetical protein ygdL. The common reaction mechanism catalyzed by E1-like enzymes begins with a nucleophilic attack of the C-terminal carboxylate of the ubiquitin-like...; Region: YgdL_like; cd00755 508765009648 putative ATP binding site [chemical binding]; other site 508765009649 putative substrate interface [chemical binding]; other site 508765009650 5'-methylthioadenosine/S-adenosylhomocysteine nucleosidase; Validated; Region: PRK05584 508765009651 FOG: Glucan-binding domain (YG repeat) [General function prediction only]; Region: COG5263 508765009652 Putative cell wall binding repeat; Region: CW_binding_1; pfam01473 508765009653 Putative cell wall binding repeat; Region: CW_binding_1; pfam01473 508765009654 YibE/F-like protein; Region: YibE_F; pfam07907 508765009655 Polymerase and Histidinol Phosphatase domain; Region: PHP; cl17102 508765009656 DNA polymerase alpha chain like domain; Region: POLIIIAc; smart00481 508765009657 active site 508765009658 Protein of unknown function (DUF3604); Region: DUF3604; pfam12228 508765009659 Protein of unknown function (DUF3604); Region: DUF3604; pfam12228 508765009660 YhcR_OBF_like: A subfamily of OB-fold domains similar to the OB folds of Bacillus subtilis YhcR. YhcR is a sugar-nonspecific nuclease, which is active in the presence of Ca2+ and Mn2+. It cleaves RNA endonucleolytically, producing 3'-monophosphate...; Region: YhcR_OBF_like; cd04486 508765009661 generic binding surface II; other site 508765009662 generic binding surface I; other site 508765009663 dTDP-4-dehydrorhamnose 3,5-epimerase; Region: dTDP_sugar_isom; cl17405 508765009664 Hemolysins and related proteins containing CBS domains [General function prediction only]; Region: TlyC; COG1253 508765009665 Domain of unknown function DUF21; Region: DUF21; pfam01595 508765009666 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains associated with the CorC_HlyC domain. CorC_HlyC is a transporter associated domain. This small domain is found in Na+/H+ antiporters, in proteins involved in...; Region: CBS_pair_CorC_HlyC_assoc; cd04590 508765009667 Transporter associated domain; Region: CorC_HlyC; pfam03471 508765009668 Uncharacterized conserved protein [Function unknown]; Region: COG4198 508765009669 Protein of unknown function (DUF1015); Region: DUF1015; pfam06245 508765009670 Phosphoglycerate dehydrogenase and related dehydrogenases [Amino acid transport and metabolism]; Region: SerA; COG0111 508765009671 Phosphoglycerate dehydrogenase (PGDH) NAD-binding and catalytic domains; Region: PGDH_2; cd05303 508765009672 putative ligand binding site [chemical binding]; other site 508765009673 NAD binding site [chemical binding]; other site 508765009674 dimerization interface [polypeptide binding]; other site 508765009675 catalytic site [active] 508765009676 Serine-pyruvate aminotransferase/archaeal aspartate aminotransferase [Amino acid transport and metabolism]; Region: COG0075 508765009677 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 508765009678 catalytic residue [active] 508765009679 ABC-2 family transporter protein; Region: ABC2_membrane_4; pfam12730 508765009680 ABC-type transport system involved in multi-copper enzyme maturation, permease component [General function prediction only]; Region: NosY; COG1277 508765009681 ABC-type multidrug transport system, ATPase component [Defense mechanisms]; Region: CcmA; COG1131 508765009682 ATP-binding cassette domain of the drug resistance transporter and related proteins, subfamily A; Region: ABC_DR_subfamily_A; cd03230 508765009683 Walker A/P-loop; other site 508765009684 ATP binding site [chemical binding]; other site 508765009685 Q-loop/lid; other site 508765009686 ABC transporter signature motif; other site 508765009687 Walker B; other site 508765009688 D-loop; other site 508765009689 H-loop/switch region; other site 508765009690 SigmaK-factor processing regulatory protein BofA; Region: BofA; pfam07441 508765009691 Protein of unknown function (DUF2508); Region: DUF2508; pfam10704 508765009692 recombination protein RecR; Reviewed; Region: recR; PRK00076 508765009693 RecR protein; Region: RecR; pfam02132 508765009694 TOPRIM_recR: topoisomerase-primase (TOPRIM) nucleotidyl transferase/hydrolase domain of the type found in Escherichia coli RecR. RecR participates in the RecFOR pathway of homologous recombinational repair in prokaryotes. This pathway provides a...; Region: TOPRIM_recR; cd01025 508765009695 putative active site [active] 508765009696 putative metal-binding site [ion binding]; other site 508765009697 tetramer interface [polypeptide binding]; other site 508765009698 hypothetical protein; Validated; Region: PRK00153 508765009699 DNA polymerase III subunits gamma and tau; Validated; Region: PRK05563 508765009700 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 508765009701 Walker A motif; other site 508765009702 ATP binding site [chemical binding]; other site 508765009703 Walker B motif; other site 508765009704 DNA polymerase III subunit delta'; Validated; Region: PRK08485 508765009705 arginine finger; other site 508765009706 DNA polymerase III subunits gamma and tau domain III; Region: DNA_pol3_gamma3; pfam12169 508765009707 thymidylate synthase; Reviewed; Region: thyA; PRK01827 508765009708 Thymidylate synthase and pyrimidine hydroxymethylase: Thymidylate synthase (TS) and deoxycytidylate hydroxymethylase (dCMP-HMase) are homologs that catalyze analogous alkylation of C5 of pyrimidine nucleotides. Both enzymes are involved in the...; Region: TS_Pyrimidine_HMase; cd00351 508765009709 dimerization interface [polypeptide binding]; other site 508765009710 active site 508765009711 Dihydrofolate reductase [Coenzyme metabolism]; Region: FolA; COG0262 508765009712 Dihydrofolate reductase (DHFR). Reduces 7,8-dihydrofolate to 5,6,7,8-tetrahydrofolate with NADPH as a cofactor. This is an essential step in the biosynthesis of deoxythymidine phosphate since 5,6,7,8-tetrahydrofolate is required to regenerate 5; Region: DHFR; cd00209 508765009713 folate binding site [chemical binding]; other site 508765009714 NADP+ binding site [chemical binding]; other site 508765009715 Membrane-associated phospholipid phosphatase [Lipid metabolism]; Region: PgpB; COG0671 508765009716 PAP2_like_2 proteins. PAP2 is a super-family of phosphatases and haloperoxidases. This subgroup, which is specific to bacteria, lacks functional characterization and may act as a membrane-associated lipid phosphatase; Region: PAP2_like_2; cd03392 508765009717 active site 508765009718 Nucleoside deaminases include adenosine, guanine and cytosine deaminases. These enzymes are Zn dependent and catalyze the deamination of nucleosides. The zinc ion in the active site plays a central role in the proposed catalytic mechanism, activating a...; Region: nucleoside_deaminase; cd01285 508765009719 nucleoside/Zn binding site; other site 508765009720 dimer interface [polypeptide binding]; other site 508765009721 catalytic motif [active] 508765009722 Hemolysins and related proteins containing CBS domains [General function prediction only]; Region: TlyC; COG1253 508765009723 Domain of unknown function DUF21; Region: DUF21; pfam01595 508765009724 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains associated with the CorC_HlyC domain. CorC_HlyC is a transporter associated domain. This small domain is found in Na+/H+ antiporters, in proteins involved in...; Region: CBS_pair_CorC_HlyC_assoc; cd04590 508765009725 Transporter associated domain; Region: CorC_HlyC; smart01091 508765009726 Sugar kinases, ribokinase family [Carbohydrate transport and metabolism]; Region: RbsK; COG0524 508765009727 Fructokinases (FRKs) mainly from bacteria and plants are enzymes with high specificity for fructose, as are all FRKs, but they catalyzes the conversion of fructose to fructose-6-phosphate, which is an entry point into glycolysis via conversion into...; Region: bac_FRK; cd01167 508765009728 putative substrate binding site [chemical binding]; other site 508765009729 putative ATP binding site [chemical binding]; other site 508765009730 sucrose-6-phosphate hydrolase; Region: scrB_fam; TIGR01322 508765009731 Glycosyl hydrolase family 32, beta-fructosidases; Region: GH32_B_Fructosidase; cd08996 508765009732 substrate binding [chemical binding]; other site 508765009733 active site 508765009734 Glycosyl hydrolases family 32 C terminal; Region: Glyco_hydro_32C; pfam08244 508765009735 Transcriptional regulators [Transcription]; Region: PurR; COG1609 508765009736 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 508765009737 DNA binding site [nucleotide binding] 508765009738 domain linker motif; other site 508765009739 Ligand-binding domain of DNA transcription repressor specific for trehalose (TreR) which is a member of the LacI-GalR family of bacterial transcription regulators; Region: PBP1_TreR_like; cd01542 508765009740 dimerization interface [polypeptide binding]; other site 508765009741 ligand binding site [chemical binding]; other site 508765009742 PTS system, sucrose-specific IIBC component; Region: PTS-II-BC-sucr; TIGR01996 508765009743 PTS_IIB, PTS system, glucose/sucrose specific IIB subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIB_glc; cd00212 508765009744 active site turn [active] 508765009745 phosphorylation site [posttranslational modification] 508765009746 Phosphotransferase system IIC components, glucose/maltose/N-acetylglucosamine-specific [Carbohydrate transport and metabolism]; Region: PtsG; COG1263 508765009747 O-Methyltransferase involved in polyketide biosynthesis [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG3315 508765009748 Leucine carboxyl methyltransferase; Region: LCM; pfam04072 508765009749 lipoprotein releasing system, ATP-binding protein; Region: LolD_lipo_ex; TIGR02211 508765009750 ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255 508765009751 Walker A/P-loop; other site 508765009752 ATP binding site [chemical binding]; other site 508765009753 Q-loop/lid; other site 508765009754 ABC transporter signature motif; other site 508765009755 Walker B; other site 508765009756 D-loop; other site 508765009757 H-loop/switch region; other site 508765009758 Metallo-beta-lactamase superfamily; Region: Lactamase_B; cl00446 508765009759 Cation transport ATPase [Inorganic ion transport and metabolism]; Region: MgtA; COG0474 508765009760 E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122 508765009761 Soluble P-type ATPase [General function prediction only]; Region: COG4087 508765009762 Cation transporting ATPase, C-terminus; Region: Cation_ATPase_C; pfam00689 508765009763 1-acyl-sn-glycerol-3-phosphate acyltransferase [Lipid metabolism]; Region: PlsC; COG0204 508765009764 Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: AGPAT-like; Region: LPLAT_AGPAT-like; cd07989 508765009765 putative acyl-acceptor binding pocket; other site 508765009766 Superfamily II DNA and RNA helicases [DNA replication, recombination, and repair / Transcription / Translation, ribosomal structure and biogenesis]; Region: SrmB; COG0513 508765009767 DEAD-box helicases. A diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker B motif; Region: DEADc; cd00268 508765009768 ATP binding site [chemical binding]; other site 508765009769 Mg++ binding site [ion binding]; other site 508765009770 motif III; other site 508765009771 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 508765009772 nucleotide binding region [chemical binding]; other site 508765009773 ATP-binding site [chemical binding]; other site 508765009774 RNA recognition motif in the DbpA subfamily of prokaryotic DEAD-box rRNA helicases; Region: RRM_DbpA; cd12252 508765009775 RNA binding site [nucleotide binding]; other site 508765009776 Molecular chaperone (small heat shock protein) [Posttranslational modification, protein turnover, chaperones]; Region: IbpA; COG0071 508765009777 Alpha-crystallin domain (ACD) of alpha-crystallin-type small(s) heat shock proteins (Hsps). sHsps are small stress induced proteins with monomeric masses between 12 -43 kDa, whose common feature is the Alpha-crystallin domain (ACD). sHsps are generally...; Region: ACD_sHsps-like; cd06464 508765009778 putative dimer interface [polypeptide binding]; other site 508765009779 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 508765009780 Zn2+ binding site [ion binding]; other site 508765009781 Mg2+ binding site [ion binding]; other site 508765009782 Aminoglycoside 3'-phosphotransferase (APH) and Choline Kinase (ChoK) family. The APH/ChoK family is part of a larger superfamily that includes the catalytic domains of other kinases, such as the typical serine/threonine/tyrosine protein kinases (PKs)...; Region: APH_ChoK_like; cd05120 508765009783 Phosphotransferase enzyme family; Region: APH; pfam01636 508765009784 active site 508765009785 substrate binding site [chemical binding]; other site 508765009786 ATP binding site [chemical binding]; other site 508765009787 Domain of Unknown Function (DUF1540); Region: DUF1540; pfam07561 508765009788 hypothetical protein; Provisional; Region: PRK06851 508765009789 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 508765009790 Walker A motif; other site 508765009791 ATP binding site [chemical binding]; other site 508765009792 NTPase; Region: NTPase_1; cl17478 508765009793 Sulfate permease and related transporters (MFS superfamily) [Inorganic ion transport and metabolism]; Region: SUL1; COG0659 508765009794 Sulfate transporter N-terminal domain with GLY motif; Region: Sulfate_tra_GLY; pfam13792 508765009795 Sulfate transporter family; Region: Sulfate_transp; pfam00916 508765009796 Sulphate Transporter and Anti-Sigma factor antagonist domain of SulP-like sulfate transporters, plays a role in the function and regulation of the transport activity, proposed general NTP binding function; Region: STAS_SulP_like_sulfate_transporter; cd07042 508765009797 Dihydrodipicolinate synthase/N-acetylneuraminate lyase [Amino acid transport and metabolism / Cell envelope biogenesis, outer membrane]; Region: DapA; COG0329 508765009798 Dihydrodipicolinate synthase (DHDPS); Region: DHDPS; cd00950 508765009799 dimer interface [polypeptide binding]; other site 508765009800 active site 508765009801 catalytic residue [active] 508765009802 Lysine riboswitch 508765009803 Metal-dependent hydrolases of the beta-lactamase superfamily III [General function prediction only]; Region: ElaC; COG1234 508765009804 hypothetical protein; Provisional; Region: PRK10621 508765009805 Sulfite exporter TauE/SafE; Region: TauE; pfam01925 508765009806 Protein of unknown function (DUF1461); Region: DUF1461; pfam07314 508765009807 Predicted esterase of the alpha-beta hydrolase superfamily [General function prediction only]; Region: RssA; COG1752 508765009808 Hypothetical patatin similar to Z1214 protein of Escherichia coli; Region: Pat_hypo_Ecoli_Z1214_like; cd07209 508765009809 active site 508765009810 nucleophile elbow; other site 508765009811 PEP synthetase regulatory protein; Provisional; Region: PRK05339 508765009812 Signal peptidase (SPase) II; Region: Peptidase_A8; cl00458 508765009813 [FeFe] hydrogenase H-cluster maturation GTPase HydF; Region: GTP_HydF; TIGR03918 508765009814 E. coli Ras-like protein (Era)-like GTPase; Region: Era_like; cd00880 508765009815 G1 box; other site 508765009816 GTP/Mg2+ binding site [chemical binding]; other site 508765009817 Switch I region; other site 508765009818 G2 box; other site 508765009819 Switch II region; other site 508765009820 G3 box; other site 508765009821 G4 box; other site 508765009822 G5 box; other site 508765009823 Flagellar motor protein [Cell motility and secretion]; Region: MotB; COG1360 508765009824 Membrane MotB of proton-channel complex MotA/MotB; Region: MotB_plug; pfam13677 508765009825 Peptidoglycan binding domains similar to the C-terminal domain of outer-membrane protein OmpA; Region: OmpA_C-like; cd07185 508765009826 ligand binding site [chemical binding]; other site 508765009827 Flagellar motor component [Cell motility and secretion]; Region: MotA; COG1291 508765009828 MotA/TolQ/ExbB proton channel family; Region: MotA_ExbB; cl00568 508765009829 L-lactate dehydrogenase; Reviewed; Region: ldh; PRK00066 508765009830 L-2-hydroxyisocapronate dehydrogenases and some bacterial L-lactate dehydrogenases; Region: HicDH_like; cd05291 508765009831 NAD binding site [chemical binding]; other site 508765009832 dimer interface [polypeptide binding]; other site 508765009833 tetramer (dimer of dimers) interface [polypeptide binding]; other site 508765009834 substrate binding site [chemical binding]; other site 508765009835 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 508765009836 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cl00080 508765009837 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 508765009838 ATP binding site [chemical binding]; other site 508765009839 Mg2+ binding site [ion binding]; other site 508765009840 G-X-G motif; other site 508765009841 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 508765009842 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 508765009843 active site 508765009844 phosphorylation site [posttranslational modification] 508765009845 intermolecular recognition site; other site 508765009846 dimerization interface [polypeptide binding]; other site 508765009847 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 508765009848 DNA binding site [nucleotide binding] 508765009849 FtsX-like permease family; Region: FtsX; pfam02687 508765009850 FtsX-like permease family; Region: FtsX; pfam02687 508765009851 ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136 508765009852 ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255 508765009853 Walker A/P-loop; other site 508765009854 ATP binding site [chemical binding]; other site 508765009855 Q-loop/lid; other site 508765009856 ABC transporter signature motif; other site 508765009857 Walker B; other site 508765009858 D-loop; other site 508765009859 H-loop/switch region; other site 508765009860 Transcriptional regulators [Transcription]; Region: MarR; COG1846 508765009861 MarR family; Region: MarR; pfam01047 508765009862 TRX family; composed of two groups: Group I, which includes proteins that exclusively encode a TRX domain; and Group II, which are composed of fusion proteins of TRX and additional domains. Group I TRX is a small ancient protein that alter the redox...; Region: TRX_family; cd02947 508765009863 catalytic residues [active] 508765009864 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 508765009865 Zn2+ binding site [ion binding]; other site 508765009866 Mg2+ binding site [ion binding]; other site 508765009867 TIGR03987 family protein; Region: TIGR03987 508765009868 helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347 508765009869 MarR family; Region: MarR_2; pfam12802 508765009870 Transketolase, C-terminal subunit [Carbohydrate transport and metabolism]; Region: COG3958 508765009871 Pyrimidine (PYR) binding domain of 1-deoxy-D-xylulose-5-phosphate synthase (DXS), transketolase (TK), and related proteins; Region: TPP_PYR_DXS_TK_like; cd07033 508765009872 PYR/PP interface [polypeptide binding]; other site 508765009873 dimer interface [polypeptide binding]; other site 508765009874 TPP binding site [chemical binding]; other site 508765009875 Transketolase, C-terminal domain; Region: Transketolase_C; pfam02780 508765009876 transketolase; Reviewed; Region: PRK05899 508765009877 Thiamine pyrophosphate (TPP) family, Transketolase (TK) subfamily, TPP-binding module; TK catalyzes the transfer of a two-carbon unit from ketose phosphates to aldose phosphates. In heterotrophic organisms, TK provides a link between glycolysis and the...; Region: TPP_TK; cd02012 508765009878 TPP-binding site [chemical binding]; other site 508765009879 dimer interface [polypeptide binding]; other site 508765009880 PTS system ascorbate-specific transporter subunit IIC; Reviewed; Region: ulaA; PRK09410 508765009881 PTS_IIB_ascorbate: subunit IIB of enzyme II (EII) of the L-ascorbate-specific phosphoenolpyruvate:carbohydrate phosphotransferase system (PTS). In this system, EII is an L-ascorbate-specific permease with two cytoplasmic subunits (IIA and IIB) and a...; Region: PTS_IIB_ascorbate; cd05563 508765009882 active site 508765009883 P-loop; other site 508765009884 phosphorylation site [posttranslational modification] 508765009885 PTS_IIA, PTS system, fructose/mannitol specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_fru; cd00211 508765009886 active site 508765009887 phosphorylation site [posttranslational modification] 508765009888 Transcriptional antiterminator [Transcription]; Region: BglG; COG3711 508765009889 HTH domain; Region: HTH_11; pfam08279 508765009890 PRD domain; Region: PRD; pfam00874 508765009891 PTS_IIB_bgl_like: the PTS (phosphotransferase system) IIB domain of a family of sensory systems composed of a membrane-bound sugar-sensor (similar to BglF) and a transcription antiterminator (similar to BglG) which regulate expression of genes involved...; Region: PTS_IIB_bgl_like; cd05568 508765009892 active site 508765009893 P-loop; other site 508765009894 phosphorylation site [posttranslational modification] 508765009895 PTS_IIA, PTS system, fructose/mannitol specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_fru; cd00211 508765009896 active site 508765009897 phosphorylation site [posttranslational modification] 508765009898 alpha,alpha-phosphotrehalase; Region: trehalose_treC; TIGR02403 508765009899 Alpha amylase catalytic domain found in Sucrose isomerases, oligo-1,6-glucosidase (also called isomaltase; sucrase-isomaltase; alpha-limit dextrinase), dextran glucosidase (also called glucan 1,6-alpha-glucosidase), and related proteins; Region: AmyAc_SI_OligoGlu_DGase; cd11333 508765009900 Ca binding site [ion binding]; other site 508765009901 active site 508765009902 catalytic site [active] 508765009903 AraC-like ligand binding domain; Region: AraC_binding; pfam02311 508765009904 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 508765009905 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 508765009906 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 508765009907 DNA-directed RNA polymerase specialized sigma subunit, sigma24 homolog [Transcription]; Region: RpoE; COG1595 508765009908 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 508765009909 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 508765009910 DNA binding residues [nucleotide binding] 508765009911 Phosphate/sulphate permeases [Inorganic ion transport and metabolism]; Region: PitA; COG0306 508765009912 Phosphate transport regulator (distant homolog of PhoU) [Inorganic ion transport and metabolism]; Region: COG1392 508765009913 GxGYxY sequence motif in domain of unknown function; Region: GxGYxYP; pfam14323 508765009914 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 508765009915 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 508765009916 dimer interface [polypeptide binding]; other site 508765009917 phosphorylation site [posttranslational modification] 508765009918 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 508765009919 ATP binding site [chemical binding]; other site 508765009920 Mg2+ binding site [ion binding]; other site 508765009921 G-X-G motif; other site 508765009922 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 508765009923 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 508765009924 active site 508765009925 phosphorylation site [posttranslational modification] 508765009926 intermolecular recognition site; other site 508765009927 dimerization interface [polypeptide binding]; other site 508765009928 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 508765009929 DNA binding site [nucleotide binding] 508765009930 glycerophosphodiester phosphodiesterase; Provisional; Region: glpQ; PRK11143 508765009931 Glycerophosphodiester phosphodiesterase domain of Escherichia coli (GlpQ) and similar proteins; Region: GDPD_EcGlpQ_like; cd08600 508765009932 active site 508765009933 catalytic site [active] 508765009934 metal binding site [ion binding]; metal-binding site 508765009935 ATP-dependent RNA helicase RhlE; Provisional; Region: PRK10590 508765009936 DEAD-box helicases. A diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker B motif; Region: DEADc; cd00268 508765009937 ATP binding site [chemical binding]; other site 508765009938 Mg++ binding site [ion binding]; other site 508765009939 motif III; other site 508765009940 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 508765009941 nucleotide binding region [chemical binding]; other site 508765009942 ATP-binding site [chemical binding]; other site 508765009943 Probable zinc-binding domain; Region: zf-trcl; pfam13451 508765009944 rRNA large subunit methyltransferase; Provisional; Region: PRK00103 508765009945 Uncharacterized ACR, YkgG family COG1556; Region: DUF162; pfam02589 508765009946 hypothetical protein; Provisional; Region: PRK05590 508765009947 Metal-dependent hydrolases of the beta-lactamase superfamily I [General function prediction only]; Region: PhnP; COG1235 508765009948 UDP-N-acetylglucosamine 1-carboxyvinyltransferase; Region: murA; TIGR01072 508765009949 UDP-N-acetylglucosamine enolpyruvyl transferase catalyzes enolpyruvyl transfer as part of the first step in the biosynthesis of peptidoglycan, a component of the bacterial cell wall. The reaction is phosphoenolpyruvate + UDP-N-acetyl-D-glucosamine =...; Region: UdpNAET; cd01555 508765009950 hinge; other site 508765009951 active site 508765009952 Nucleoside Triphosphate Pyrophosphohydrolase (EC 3.6.1.8) MazG-like domain superfamily; Region: NTP-PPase; cl16941 508765009953 metal binding site [ion binding]; metal-binding site 508765009954 Protein of unknown function, DUF606; Region: DUF606; pfam04657 508765009955 Predicted Zn-dependent hydrolases of the beta-lactamase fold [General function prediction only]; Region: COG2220 508765009956 Beta-lactamase superfamily domain; Region: Lactamase_B_2; pfam12706 508765009957 Peptidase domain in the S8 and S53 families; Region: Peptidases_S8_S53; cl10459 508765009958 active site 508765009959 catalytic residues [active] 508765009960 G5 domain; Region: G5; pfam07501 508765009961 Membrane proteins related to metalloendopeptidases [Cell envelope biogenesis, outer membrane]; Region: NlpD; COG0739 508765009962 Peptidase family M23; Region: Peptidase_M23; pfam01551 508765009963 Replication initiation and membrane attachment; Region: DnaB_2; pfam07261 508765009964 Replication initiation and membrane attachment; Region: DnaB_2; cl12121 508765009965 DNA replication protein DnaC; Validated; Region: PRK06835 508765009966 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cl17189 508765009967 Walker A motif; other site 508765009968 ATP binding site [chemical binding]; other site 508765009969 flavoprotein, HI0933 family; Region: TIGR00275 508765009970 Acyl-ACP thioesterase; Region: Acyl-ACP_TE; pfam01643 508765009971 4-hydroxybenzoyl-CoA thioesterase (4HBT). Catalyzes the final step in the 4-chlorobenzoate degradation pathway in which 4-chlorobenzoate is converted to 4-hydroxybenzoate in certain soil-dwelling bacteria. 4HBT forms a homotetramer with four active sites; Region: 4HBT; cd00586 508765009972 active site 508765009973 Thioesterase-like superfamily; Region: 4HBT_2; pfam13279 508765009974 active site 2 [active] 508765009975 hybrid cluster protein-associated redox disulfide domain; Region: prismane_assoc; TIGR03980 508765009976 Adenylosuccinate synthetase (AdSS) catalyzes the first step in the de novo biosynthesis of AMP. IMP and L-aspartate are conjugated in a two-step reaction accompanied by the hydrolysis of GTP to GDP in the presence of Mg2+. In the first step, the...; Region: AdSS; cd03108 508765009977 Adenylosuccinate synthetase; Region: Adenylsucc_synt; smart00788 508765009978 GDP-binding site [chemical binding]; other site 508765009979 ACT binding site; other site 508765009980 IMP binding site; other site 508765009981 Malic enzyme [Energy production and conversion]; Region: SfcA; COG0281 508765009982 Malic enzyme, N-terminal domain; Region: malic; pfam00390 508765009983 NAD(P) binding domain of malic enzyme (ME), subgroup 2; Region: NAD_bind_2_malic_enz; cd05311 508765009984 putative NAD(P) binding site [chemical binding]; other site 508765009985 pyrroline-5-carboxylate reductase; Reviewed; Region: PRK11880 508765009986 pyrroline-5-carboxylate reductase; Region: PLN02688 508765009987 replicative DNA helicase; Provisional; Region: PRK05595 508765009988 DnaB-like helicase N terminal domain; Region: DnaB; pfam00772 508765009989 DnaB helicase C terminal domain. The hexameric helicase DnaB unwinds the DNA duplex at the chromosome replication fork. Although the mechanism by which DnaB both couples ATP hydrolysis to translocation along DNA and denatures the duplex is unknown, a...; Region: DnaB_C; cd00984 508765009990 Walker A motif; other site 508765009991 ATP binding site [chemical binding]; other site 508765009992 Walker B motif; other site 508765009993 DNA binding loops [nucleotide binding] 508765009994 ATP-dependent protease, Lon family; Region: spore_lon_C; TIGR02903 508765009995 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 508765009996 Walker A motif; other site 508765009997 ATP binding site [chemical binding]; other site 508765009998 Walker B motif; other site 508765009999 arginine finger; other site 508765010000 Lon protease (S16) C-terminal proteolytic domain; Region: Lon_C; pfam05362 508765010001 50S ribosomal protein L9; Reviewed; Region: rplI; PRK00137 508765010002 Ribosomal protein L9, N-terminal domain; Region: Ribosomal_L9_N; pfam01281 508765010003 Ribosomal protein L9, C-terminal domain; Region: Ribosomal_L9_C; pfam03948 508765010004 Predicted signaling protein consisting of a modified GGDEF domain and a DHH domain [Signal transduction mechanisms]; Region: COG3887 508765010005 DHH family; Region: DHH; pfam01368 508765010006 DHHA1 domain; Region: DHHA1; pfam02272 508765010007 MazG-like family; Region: MazG-like; pfam12643 508765010008 30S ribosomal protein S18; Reviewed; Region: rpsR; PRK00391 508765010009 Single-stranded DNA-binding protein [DNA replication, recombination, and repair]; Region: Ssb; COG0629 508765010010 SSB_OBF: A subfamily of OB folds similar to the OB fold of ssDNA-binding protein (SSB). SSBs bind with high affinity to ssDNA. They bind to and protect ssDNA intermediates during DNA metabolic pathways. All bacterial and eukaryotic SSBs studied to date...; Region: SSB_OBF; cd04496 508765010011 dimer interface [polypeptide binding]; other site 508765010012 ssDNA binding site [nucleotide binding]; other site 508765010013 tetramer (dimer of dimers) interface [polypeptide binding]; other site 508765010014 30S ribosomal protein S6; Reviewed; Region: rpsF; PRK00453 508765010015 Bacterial protein of unknown function (DUF951); Region: DUF951; pfam06107 508765010016 Small-conductance mechanosensitive channel [Cell envelope biogenesis, outer membrane]; Region: MscS; COG0668 508765010017 Mechanosensitive ion channel; Region: MS_channel; pfam00924 508765010018 Protein of unknown function (DUF3343); Region: DUF3343; pfam11823 508765010019 Putative threonine efflux protein [Amino acid transport and metabolism]; Region: RhtB; COG1280 508765010020 Selenocysteine lyase/Cysteine desulfurase [Posttranslational modification, protein turnover, chaperones]; Region: csdA; COG0520 508765010021 Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321 508765010022 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 508765010023 catalytic residue [active] 508765010024 Protein of unknown function (DUF1256); Region: DUF1256; cl06087 508765010025 ParB-like nuclease domain; Region: ParBc; pfam02195 508765010026 ParB/RepB/Spo0J family partition protein; Region: parB_part; TIGR00180 508765010027 ATPases involved in chromosome partitioning [Cell division and chromosome partitioning]; Region: Soj; COG1192 508765010028 ParA and ParB of Caulobacter crescentus belong to a conserved family of bacterial proteins implicated in chromosome segregation. ParB binds to DNA sequences adjacent to the origin of replication and localizes to opposite cell poles shortly following the...; Region: ParA; cd02042 508765010029 P-loop; other site 508765010030 Magnesium ion binding site [ion binding]; other site 508765010031 ParA and ParB of Caulobacter crescentus belong to a conserved family of bacterial proteins implicated in chromosome segregation. ParB binds to DNA sequences adjacent to the origin of replication and localizes to opposite cell poles shortly following the...; Region: ParA; cd02042 508765010032 Magnesium ion binding site [ion binding]; other site 508765010033 nucleoid occlusion protein; Region: nucleoid_noc; TIGR04285 508765010034 ParB-like nuclease domain; Region: ParB; smart00470 508765010035 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cl17200 508765010036 Predicted S-adenosylmethionine-dependent methyltransferase involved in bacterial cell division [Cell envelope biogenesis, outer membrane]; Region: GidB; COG0357 508765010037 16S rRNA methyltransferase GidB; Reviewed; Region: gidB; PRK00107 508765010038 tRNA uridine 5-carboxymethylaminomethyl modification enzyme GidA; Validated; Region: PRK05192 508765010039 NAD(FAD)-utilizing enzyme possibly involved in translation [Translation, ribosomal structure and biogenesis]; Region: Gid; COG1206 508765010040 GidA associated domain 3; Region: GIDA_assoc_3; pfam13932 508765010041 tRNA modification GTPase TrmE; Reviewed; Region: trmE; PRK05291 508765010042 GTP-binding protein TrmE N-terminus; Region: TrmE_N; pfam10396 508765010043 trmE is a tRNA modification GTPase; Region: trmE; cd04164 508765010044 G1 box; other site 508765010045 GTP/Mg2+ binding site [chemical binding]; other site 508765010046 Switch I region; other site 508765010047 G2 box; other site 508765010048 Switch II region; other site 508765010049 G3 box; other site 508765010050 G4 box; other site 508765010051 G5 box; other site 508765010052 Catalytic cysteine-containing C-terminus of GTPase, MnmE; Region: GTPase_Cys_C; pfam12631 508765010053 Predicted RNA-binding protein [General function prediction only]; Region: Jag; COG1847 508765010054 jag_K homology RNA-binding domain. The KH domain is found in proteins homologous to the Bacillus subtilis protein Jag, which is associated with SpoIIIJ and is necessary for the third stage of sporulation. The KH motif is a beta-alpha-alpha-beta-beta...; Region: jag_KH; cd02414 508765010055 G-X-X-G motif; other site 508765010056 R3H domain found in proteins homologous to Bacillus subtilus Jag, which is associated with SpoIIIJ. SpoIIIJ is necessary for the third stage of sporulation. The name of the R3H domain comes from the characteristic spacing of the most conserved arginine...; Region: R3H_jag; cd02644 508765010057 RxxxH motif; other site 508765010058 putative inner membrane protein translocase component YidC; Provisional; Region: PRK00145 508765010059 ribonuclease P; Reviewed; Region: rnpA; PRK00499 508765010060 50S ribosomal protein L34; Reviewed; Region: rpmH; PRK00399 508765010061 Putative cell wall binding repeat; Region: CW_binding_1; pfam01473 508765010062 Type IV secretory pathway, VirD4 components [Intracellular trafficking and secretion]; Region: VirD4; COG3505 508765010063 RecA-like NTPases. This family includes the NTP binding domain of F1 and V1 H+ATPases, DnaB and related helicases as well as bacterial RecA and related eukaryotic and archaeal recombinases. This group also includes bacterial conjugation proteins and...; Region: RecA-like_NTPases; cl17233 508765010064 Walker A motif; other site 508765010065 ATP binding site [chemical binding]; other site 508765010066 Walker B motif; other site 508765010067 AAA-like domain; Region: AAA_10; pfam12846 508765010068 Soluble lytic murein transglycosylase and related regulatory proteins (some contain LysM/invasin domains) [Cell envelope biogenesis, outer membrane]; Region: MltE; COG0741 508765010069 Lytic Transglycosylase (LT) and Goose Egg White Lysozyme (GEWL) domain. Members include the soluble and insoluble membrane-bound LTs in bacteria, the LTs in bacteriophage lambda, as well as, the eukaryotic "goose-type" lysozymes (GEWL). LTs...; Region: LT_GEWL; cd00254 508765010070 N-acetyl-D-glucosamine binding site [chemical binding]; other site 508765010071 catalytic residue [active] 508765010072 Cell wall-associated hydrolases (invasion-associated proteins) [Cell envelope biogenesis, outer membrane]; Region: Spr; COG0791 508765010073 NlpC/P60 family; Region: NLPC_P60; pfam00877 508765010074 Pentapeptide repeats (9 copies); Region: Pentapeptide_4; pfam13599 508765010075 Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805 508765010076 Single-stranded DNA-binding protein [DNA replication, recombination, and repair]; Region: Ssb; COG0629 508765010077 SSB_OBF: A subfamily of OB folds similar to the OB fold of ssDNA-binding protein (SSB). SSBs bind with high affinity to ssDNA. They bind to and protect ssDNA intermediates during DNA metabolic pathways. All bacterial and eukaryotic SSBs studied to date...; Region: SSB_OBF; cd04496 508765010078 dimer interface [polypeptide binding]; other site 508765010079 ssDNA binding site [nucleotide binding]; other site 508765010080 tetramer (dimer of dimers) interface [polypeptide binding]; other site 508765010081 Clostridium enterotoxin; Region: Clenterotox; pfam03505 508765010082 Clostridium enterotoxin; Region: Clenterotox; pfam03505 508765010083 Clostridium botulinum HA-17 protein; Region: Botulinum_HA-17; pfam05588 508765010084 Ricin-type beta-trefoil; Carbohydrate-binding domain formed from presumed gene triplication. The domain is found in a variety of molecules serving diverse functions such as enzymatic activity, inhibitory toxicity and signal transduction. Highly specific...; Region: RICIN; cd00161 508765010085 Ricin-type beta-trefoil; Region: RICIN; smart00458 508765010086 putative sugar binding sites [chemical binding]; other site 508765010087 Q-X-W motif; other site 508765010088 clostridium toxin-associated regulator BotR; Region: P21_Cbot; TIGR03209 508765010089 Sigma-70, region 4; Region: Sigma70_r4_2; pfam08281 508765010090 DNA binding residues [nucleotide binding] 508765010091 Clostridial neurotoxin zinc protease; Region: Peptidase_M27; pfam01742 508765010092 Clostridium neurotoxin, Translocation domain; Region: Toxin_trans; pfam07952 508765010093 Clostridium neurotoxin, N-terminal receptor binding; Region: Toxin_R_bind_N; pfam07953 508765010094 Nontoxic nonhaemagglutinin C-terminal; Region: NTNH_C; pfam08470 508765010095 Clostridial neurotoxin zinc protease; Region: Peptidase_M27; pfam01742 508765010096 Clostridium neurotoxin, Translocation domain; Region: Toxin_trans; pfam07952 508765010097 Clostridium neurotoxin, N-terminal receptor binding; Region: Toxin_R_bind_N; pfam07953 508765010098 Clostridium neurotoxin, C-terminal receptor binding; Region: Toxin_R_bind_C; pfam07951 508765010099 Site-specific recombinases, DNA invertase Pin homologs [DNA replication, recombination, and repair]; Region: PinR; COG1961 508765010100 Serine Recombinase (SR) family, Resolvase and Invertase subfamily, catalytic domain; members contain a C-terminal DNA binding domain. Serine recombinases catalyze site-specific recombination of DNA molecules by a concerted, four-strand cleavage and...; Region: SR_ResInv; cd03768 508765010101 catalytic residues [active] 508765010102 catalytic nucleophile [active] 508765010103 Presynaptic Site I dimer interface [polypeptide binding]; other site 508765010104 Synaptic Antiparallel dimer interface [polypeptide binding]; other site 508765010105 Synaptic Flat tetramer interface [polypeptide binding]; other site 508765010106 Synaptic Site I dimer interface [polypeptide binding]; other site 508765010107 DNA binding site [nucleotide binding] 508765010108 multiple promoter invertase; Provisional; Region: mpi; PRK13413 508765010109 Serine Recombinase (SR) family, Resolvase and Invertase subfamily, catalytic domain; members contain a C-terminal DNA binding domain. Serine recombinases catalyze site-specific recombination of DNA molecules by a concerted, four-strand cleavage and...; Region: SR_ResInv; cd03768 508765010110 catalytic residues [active] 508765010111 catalytic nucleophile [active] 508765010112 Presynaptic Site I dimer interface [polypeptide binding]; other site 508765010113 Synaptic Antiparallel dimer interface [polypeptide binding]; other site 508765010114 Synaptic Flat tetramer interface [polypeptide binding]; other site 508765010115 Synaptic Site I dimer interface [polypeptide binding]; other site 508765010116 Helix-turn-helix domain of Hin and related proteins, a family of DNA-binding domains unique to bacteria and represented by the Hin protein of Salmonella. The basic HTH domain is a simple fold comprised of three core helices that form a right-handed...; Region: HTH_Hin_like; cd00569 508765010117 DNA-binding interface [nucleotide binding]; DNA binding site 508765010118 Transglutaminase-like superfamily; Region: Transglut_core; pfam01841 508765010119 Plasmid segregation protein ParM and similar proteins; Region: ParM_like; cd10227 508765010120 Mg binding site [ion binding]; other site 508765010121 nucleotide binding site [chemical binding]; other site 508765010122 putative protofilament interface [polypeptide binding]; other site 508765010123 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 508765010124 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 508765010125 non-specific DNA binding site [nucleotide binding]; other site 508765010126 salt bridge; other site 508765010127 sequence-specific DNA binding site [nucleotide binding]; other site 508765010128 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 508765010129 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 508765010130 non-specific DNA binding site [nucleotide binding]; other site 508765010131 salt bridge; other site 508765010132 sequence-specific DNA binding site [nucleotide binding]; other site 508765010133 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 508765010134 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 508765010135 non-specific DNA binding site [nucleotide binding]; other site 508765010136 salt bridge; other site 508765010137 sequence-specific DNA binding site [nucleotide binding]; other site 508765010138 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 508765010139 non-specific DNA binding site [nucleotide binding]; other site 508765010140 salt bridge; other site 508765010141 sequence-specific DNA binding site [nucleotide binding]; other site 508765010142 Putative cell wall binding repeat; Region: CW_binding_1; pfam01473 508765010143 glucan-binding repeat; Region: glucan_65_rpt; TIGR04035 508765010144 Putative cell wall binding repeat; Region: CW_binding_1; pfam01473 508765010145 Putative cell wall binding repeat; Region: CW_binding_1; pfam01473 508765010146 Putative cell wall binding repeat; Region: CW_binding_1; pfam01473