-- dump date   	20140619_043428
-- class       	Genbank::misc_feature
-- table       	misc_feature_note
-- id	note
929506000001	Helix-turn-helix domain; Region: HTH_17; cl17695
929506000002	Helix-Turn-Helix DNA binding domain of transcription regulators from the MerR superfamily; Region: HTH_MerR-SF; cl02600
929506000003	DNA binding residues [nucleotide binding]
929506000004	Predicted site-specific integrase-resolvase [DNA replication, recombination, and repair]; Region: COG2452
929506000005	Serine Recombinase (SR) family, IS607-like transposase subfamily, catalytic domain; members contain a DNA binding domain with homology to MerR/SoxR located N-terminal to the catalytic domain. Serine recombinases catalyze site-specific recombination of...; Region: SR_IS607_transposase_like; cd03769
929506000006	catalytic residues [active]
929506000007	catalytic nucleophile [active]
929506000008	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG0675
929506000009	Helix-turn-helix domain; Region: HTH_OrfB_IS605; pfam12323
929506000010	Probable transposase; Region: OrfB_IS605; pfam01385
929506000011	transposase, IS605 OrfB family, central region; Region: tspaseT_teng_C; TIGR01766
929506000012	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG0675
929506000013	Helix-turn-helix domain; Region: HTH_OrfB_IS605; pfam12323
929506000014	Probable transposase; Region: OrfB_IS605; pfam01385
929506000015	transposase, IS605 OrfB family, central region; Region: tspaseT_teng_C; TIGR01766
929506000016	This entry represents the putative helicase A859L; Region: T5orf172; smart00974
929506000017	Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745
929506000018	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
929506000019	active site
929506000020	phosphorylation site [posttranslational modification]
929506000021	intermolecular recognition site; other site
929506000022	dimerization interface [polypeptide binding]; other site
929506000023	Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383
929506000024	DNA binding site [nucleotide binding]
929506000025	dimerization interface [polypeptide binding]; other site
929506000026	HAMP (Histidine kinases, Adenylyl cyclases, Methyl binding proteins, Phosphatases) domain; Region: HAMP; smart00304
929506000027	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG0675
929506000028	Helix-turn-helix domain; Region: HTH_OrfB_IS605; pfam12323
929506000029	Probable transposase; Region: OrfB_IS605; pfam01385
929506000030	transposase, IS605 OrfB family, central region; Region: tspaseT_teng_C; TIGR01766
929506000031	Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642
929506000032	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
929506000033	dimer interface [polypeptide binding]; other site
929506000034	phosphorylation site [posttranslational modification]
929506000035	Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase; Region: HATPase_c; pfam02518
929506000036	ATP binding site [chemical binding]; other site
929506000037	Mg2+ binding site [ion binding]; other site
929506000038	G-X-G motif; other site
929506000039	Cro/C1-type HTH DNA-binding domain; Region: HTH_26; pfam13443
929506000040	phosphopyruvate hydratase; Region: eno; TIGR01060
929506000041	CRISPR/Cas system-associated RAMP superfamily protein Cas7; Region: Cas7_I-C; cl01465
929506000042	Ribbon-helix-helix domain; Region: RHH_3; pfam12651
929506000043	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG0675
929506000044	Helix-turn-helix domain; Region: HTH_OrfB_IS605; pfam12323
929506000045	Probable transposase; Region: OrfB_IS605; pfam01385
929506000046	transposase, IS605 OrfB family, central region; Region: tspaseT_teng_C; TIGR01766
929506000047	CRISPR/Cas system-associated RAMP superfamily protein Cas5; Region: Cas5_I; cl12040
929506000048	Transposase, Mutator family; Region: Transposase_mut; pfam00872
929506000049	MULE transposase domain; Region: MULE; pfam10551
929506000050	CRISPR/Cas system-associated protein Cas3'' Region: Cas3''_I; cd09641
929506000051	DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cl17251
929506000052	Predicted site-specific integrase-resolvase [DNA replication, recombination, and repair]; Region: COG2452
929506000053	Helix-Turn-Helix DNA binding domain of truncated MerR-like proteins; Region: HTH_MerR-trunc; cd04762
929506000054	DNA binding residues [nucleotide binding]
929506000055	Serine Recombinase (SR) family, IS607-like transposase subfamily, catalytic domain; members contain a DNA binding domain with homology to MerR/SoxR located N-terminal to the catalytic domain. Serine recombinases catalyze site-specific recombination of...; Region: SR_IS607_transposase_like; cd03769
929506000056	catalytic residues [active]
929506000057	catalytic nucleophile [active]
929506000058	Probable transposase; Region: OrfB_IS605; pfam01385
929506000059	transposase, IS605 OrfB family, central region; Region: tspaseT_teng_C; TIGR01766
929506000060	Putative transposase DNA-binding domain; Region: OrfB_Zn_ribbon; pfam07282
929506000061	PemK-like protein; Region: PemK; pfam02452
929506000062	DNA-sulfur modification-associated; Region: DndB; pfam14072
929506000063	DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213
929506000064	NAD-dependent DNA ligase LigA; Validated; Region: ligA; PRK07956
929506000065	NAD+ dependent DNA ligase adenylation domain. DNA ligases catalyze the crucial step of joining the breaks in duplex DNA during DNA replication, repair and recombination, utilizing either ATP or NAD(+) as a cofactor, but using the same basic reaction...; Region: LIGANc; cl03295
929506000066	nucleotide binding pocket [chemical binding]; other site
929506000067	K-X-D-G motif; other site
929506000068	catalytic site [active]
929506000069	NAD-dependent DNA ligase OB-fold domain; Region: DNA_ligase_OB; pfam03120
929506000070	Breast Cancer Suppressor Protein (BRCA1), carboxy-terminal domain. The BRCT domain is found within many DNA damage repair and cell cycle checkpoint proteins. The unique diversity of this domain superfamily allows BRCT modules to interact forming homo...; Region: BRCT; cd00027
929506000071	Dimer interface [polypeptide binding]; other site
929506000072	BRCT sequence motif; other site
929506000073	3'-phosphoadenosine 5'-phosphosulfate sulfotransferase (PAPS reductase)/FAD synthetase and related enzymes [Amino acid transport and metabolism / Coenzyme metabolism]; Region: CysH; COG0175
929506000074	This domain is found in phosphoadenosine phosphosulphate (PAPS) reductase enzymes or PAPS sulphotransferase. PAPS reductase is part of the adenine nucleotide alpha hydrolases superfamily also including N type ATP PPases and ATP sulphurylases. A highly...; Region: PAPS_reductase; cd01713
929506000075	Active Sites [active]
929506000076	Uncharacterized phage-encoded protein [Function unknown]; Region: COG3646
929506000077	Phage regulatory protein Rha (Phage_pRha); Region: Phage_pRha; pfam09669
929506000078	Cytosine-C5 specific DNA methylases; Methyl transfer reactions play an important role in many aspects of biology. Cytosine-specific DNA methylases are found both in prokaryotes and eukaryotes. DNA methylation, or the covalent addition of a methyl group...; Region: Cyt_C5_DNA_methylase; cd00315
929506000079	cofactor binding site; other site
929506000080	Cytosine-C5 specific DNA methylases; Methyl transfer reactions play an important role in many aspects of biology. Cytosine-specific DNA methylases are found both in prokaryotes and eukaryotes. DNA methylation, or the covalent addition of a methyl group...; Region: Cyt_C5_DNA_methylase; cd00315
929506000081	DNA-methyltransferase (dcm); Region: dcm; TIGR00675
929506000082	cofactor binding site; other site
929506000083	DNA binding site [nucleotide binding]
929506000084	substrate interaction site [chemical binding]; other site
929506000085	Cytosine-C5 specific DNA methylases; Methyl transfer reactions play an important role in many aspects of biology. Cytosine-specific DNA methylases are found both in prokaryotes and eukaryotes. DNA methylation, or the covalent addition of a methyl group...; Region: Cyt_C5_DNA_methylase; cd00315
929506000086	DNA binding site [nucleotide binding]
929506000087	substrate interaction site [chemical binding]; other site
929506000088	Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090
929506000089	dimerization interface [polypeptide binding]; other site
929506000090	putative DNA binding site [nucleotide binding]; other site
929506000091	putative Zn2+ binding site [ion binding]; other site
929506000092	Predicted permeases [General function prediction only]; Region: COG0701
929506000093	Thioredoxin domain; Region: Thioredoxin_3; pfam13192
929506000094	maltose O-acetyltransferase; Provisional; Region: PRK10092
929506000095	Maltose O-acetyltransferase (MAT) and Galactoside O-acetyltransferase (GAT): MAT and GAT catalyze the CoA-dependent acetylation of the 6-hydroxyl group of their respective sugar substrates. MAT acetylates maltose and glucose exclusively at the C6...; Region: LbH_MAT_GAT; cd03357
929506000096	active site
929506000097	substrate binding site [chemical binding]; other site
929506000098	trimer interface [polypeptide binding]; other site
929506000099	CoA binding site [chemical binding]; other site
929506000100	Guanylate kinase [Nucleotide transport and metabolism]; Region: Gmk; COG0194
929506000101	Nucleoside/nucleotide kinase (NK) is a protein superfamily consisting of multiple families of enzymes that share structural similarity and are functionally related to the catalysis of the reversible phosphate group transfer from nucleoside triphosphates...; Region: NK; cl17190
929506000102	active site
929506000103	Uncharacterized protein family (UPF0150); Region: UPF0150; pfam03681
929506000104	RT_G2_intron: Reverse transcriptases (RTs) with group II intron origin. RT transcribes DNA using RNA as template. Proteins in this subfamily are found in bacterial and mitochondrial group II introns. Their most probable ancestor was a retrotransposable...; Region: RT_G2_intron; cd01651
929506000105	Reverse transcriptase (RNA-dependent DNA polymerase); Region: RVT_1; pfam00078
929506000106	putative active site [active]
929506000107	putative NTP binding site [chemical binding]; other site
929506000108	putative nucleic acid binding site [nucleotide binding]; other site
929506000109	Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392
929506000110	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG4584
929506000111	DNA binding site [nucleotide binding]
929506000112	Integrase core domain; Region: rve; pfam00665
929506000113	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
929506000114	ATPases associated with a variety of cellular activities; Region: AAA; smart00382
929506000115	Walker A motif; other site
929506000116	ATP binding site [chemical binding]; other site
929506000117	Walker B motif; other site
929506000118	arginine finger; other site
929506000119	HNH nucleases; HNH endonuclease signature which is found in viral, prokaryotic, and eukaryotic proteins. The alignment includes members of the large group of homing endonucleases, yeast intron 1 protein, MutS, as well as bacterial colicins, pyocins, and...; Region: HNHc; cd00085
929506000120	active site
929506000121	integrating conjugative element relaxase, PFL_4751 family; Region: ICE_TraI_Pfluor; TIGR03760
929506000122	Replication protein A, class 2b aminoacyl-tRNA synthetases, and related proteins with oligonucleotide/oligosaccharide (OB) fold; Region: RPA_2b-aaRSs_OBF_like; cl09930
929506000123	generic binding surface I; other site
929506000124	generic binding surface II; other site
929506000125	DnaB-like helicase N terminal domain; Region: DnaB; pfam00772
929506000126	Replicative DNA helicase [DNA replication, recombination, and repair]; Region: DnaB; COG0305
929506000127	hypothetical protein; Provisional; Region: PRK08624
929506000128	PD-(D/E)XK nuclease superfamily; Region: PDDEXK_1; pfam12705
929506000129	PHP domain; Region: PHP; pfam02811
929506000130	Polymerase and Histidinol Phosphatase domain; Region: PHP; cl17102
929506000131	active site
929506000132	Bacterial DNA polymerase III alpha subunit; Region: DNA_pol3_alpha; pfam07733
929506000133	helicase, putative, RecD/TraA family; Region: recD_rel; TIGR01448
929506000134	AAA domain; Region: AAA_30; pfam13604
929506000135	Family description; Region: UvrD_C_2; pfam13538
929506000136	GIY-YIG nuclease domain superfamily; Region: GIY-YIG_SF; cl15257
929506000137	GIY-YIG motif/motif A; other site
929506000138	active site
929506000139	catalytic site [active]
929506000140	metal binding site [ion binding]; metal-binding site
929506000141	Divergent AAA domain; Region: AAA_4; pfam04326
929506000142	3D domain; Region: 3D; cl01439
929506000143	anaerobic ribonucleoside triphosphate reductase; Provisional; Region: PRK09263
929506000144	ATP cone domain; Region: ATP-cone; pfam03477
929506000145	Class III ribonucleotide reductase; Region: RNR_III; cd01675
929506000146	effector binding site; other site
929506000147	active site
929506000148	Zn binding site [ion binding]; other site
929506000149	glycine loop; other site
929506000150	anaerobic ribonucleotide reductase-activating protein; Provisional; Region: nrdG; cl15804
929506000151	4Fe-4S single cluster domain; Region: Fer4_12; pfam13353
929506000152	Trimeric dUTP diphosphatases; Region: trimeric_dUTPase; cd07557
929506000153	trimer interface [polypeptide binding]; other site
929506000154	active site
929506000155	D12 class N6 adenine-specific DNA methyltransferase; Region: MethyltransfD12; cl17344
929506000156	clostridium toxin-associated regulator BotR; Region: P21_Cbot; TIGR03209
929506000157	Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171
929506000158	DNA binding residues [nucleotide binding]
929506000159	Clostridium enterotoxin; Region: Clenterotox; pfam03505
929506000160	Clostridium enterotoxin; Region: Clenterotox; pfam03505
929506000161	Clostridium botulinum HA-17 protein; Region: Botulinum_HA-17; pfam05588
929506000162	Ricin-type beta-trefoil; Carbohydrate-binding domain formed from presumed gene triplication. The domain is found in a variety of molecules serving diverse functions such as enzymatic activity, inhibitory toxicity and signal transduction. Highly specific...; Region: RICIN; cd00161
929506000163	Ricin-type beta-trefoil; Region: RICIN; smart00458
929506000164	putative sugar binding sites [chemical binding]; other site
929506000165	Q-X-W motif; other site
929506000166	Ricin-type beta-trefoil; Carbohydrate-binding domain formed from presumed gene triplication. The domain is found in a variety of molecules serving diverse functions such as enzymatic activity, inhibitory toxicity and signal transduction. Highly specific...; Region: RICIN; cd00161
929506000167	Ricin-type beta-trefoil; Region: RICIN; smart00458
929506000168	putative sugar binding sites [chemical binding]; other site
929506000169	Q-X-W motif; other site
929506000170	Clostridial neurotoxin zinc protease; Region: Peptidase_M27; pfam01742
929506000171	Clostridium neurotoxin, N-terminal receptor binding; Region: Toxin_R_bind_N; pfam07953
929506000172	Nontoxic nonhaemagglutinin C-terminal; Region: NTNH_C; pfam08470
929506000173	Clostridial neurotoxin zinc protease; Region: Peptidase_M27; pfam01742
929506000174	Clostridium neurotoxin, Translocation domain; Region: Toxin_trans; pfam07952
929506000175	Clostridium neurotoxin, N-terminal receptor binding; Region: Toxin_R_bind_N; pfam07953
929506000176	Clostridium neurotoxin, C-terminal receptor binding; Region: Toxin_R_bind_C; pfam07951
929506000177	Nucleoside 2-deoxyribosyltransferase; Region: Nuc_deoxyrib_tr; pfam05014
929506000178	thymidine kinase; Provisional; Region: PRK04296
929506000179	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
929506000180	ATPases associated with a variety of cellular activities; Region: AAA; smart00382
929506000181	Walker A motif; other site
929506000182	ATP binding site [chemical binding]; other site
929506000183	Walker B motif; other site
929506000184	arginine finger; other site
929506000185	Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392
929506000186	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG4584
929506000187	DNA binding site [nucleotide binding]
929506000188	Integrase core domain; Region: rve; pfam00665
929506000189	Type IIA topoisomerase (DNA gyrase/topo II, topoisomerase IV), B subunit [DNA replication, recombination, and repair]; Region: GyrB; COG0187
929506000190	DNA gyrase B; Region: DNA_gyraseB; pfam00204
929506000191	ATP binding site [chemical binding]; other site
929506000192	Topoisomerase-primase domain. This is a nucleotidyl transferase/hydrolase domain found in type IA, type IIA and type IIB topoisomerases, bacterial DnaG-type primases, small primase-like proteins from bacteria and archaea, OLD family nucleases from...; Region: TOPRIM; cl00718
929506000193	active site
929506000194	metal binding site [ion binding]; metal-binding site
929506000195	DNA gyrase B subunit, carboxyl terminus; Region: DNA_gyraseB_C; pfam00986
929506000196	Type IIA topoisomerase (DNA gyrase/topo II, topoisomerase IV), A subunit [DNA replication, recombination, and repair]; Region: GyrA; COG0188
929506000197	DNA Topoisomerase, subtype IIA; domain A'; bacterial DNA topoisomerase IV (C subunit, ParC), bacterial DNA gyrases (A subunit, GyrA),mammalian DNA toposiomerases II. DNA topoisomerases are essential enzymes that regulate the conformational changes...; Region: TOP4c; cl00148
929506000198	CAP-like domain; other site
929506000199	active site
929506000200	primary dimer interface [polypeptide binding]; other site
929506000201	5' nucleotidase, deoxy (Pyrimidine), cytosolic type C protein (NT5C); Region: NT5C; cl17836
929506000202	Phage integrase, N-terminal SAM-like domain; Region: Phage_integr_N2; pfam13495
929506000203	tyrosine recombinase XerC; Region: recomb_XerC; TIGR02224
929506000204	DNA breaking-rejoining enzymes, intergrase/recombinases, C-terminal catalytic domain. The tyrosine recombinase/integrase family share the same catalytic domain containing six conserved active site residues. The best-studied members of this diverse family...; Region: INT_REC_C; cd01182
929506000205	active site
929506000206	catalytic residues [active]
929506000207	DNA binding site [nucleotide binding]
929506000208	Int/Topo IB signature motif; other site
929506000209	Site-specific recombinase XerD [DNA replication, recombination, and repair]; Region: XerD; COG4974
929506000210	DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213
929506000211	active site
929506000212	DNA binding site [nucleotide binding]
929506000213	Int/Topo IB signature motif; other site
929506000214	PAAR motif; Region: PAAR_motif; pfam05488
929506000215	PAAR motif; Region: PAAR_motif; pfam05488
929506000216	asparagine synthase (glutamine-hydrolyzing); Region: PLN02549
929506000217	Bacterial protein of unknown function (DUF898); Region: DUF898; cl01738
929506000218	Domain of unknown function (DUF955); Region: DUF955; pfam06114
929506000219	ORF6C domain; Region: ORF6C; pfam10552
929506000220	Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396
929506000221	Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093
929506000222	sequence-specific DNA binding site [nucleotide binding]; other site
929506000223	salt bridge; other site
929506000224	PemK-like protein; Region: PemK; pfam02452
929506000225	Phosphoinositide 3-kinase (PI3K)-like family, catalytic domain; The PI3K-like catalytic domain family is part of a larger superfamily that includes the catalytic domains of other kinases such as the typical serine/threonine/tyrosine protein kinases (PKs); Region: PI3Kc_like; cl00119
929506000226	AAA domain; Region: AAA_13; pfam13166
929506000227	Phage tail protein; Region: Sipho_tail; cl17486
929506000228	Fic/DOC family; Region: Fic; cl00960
929506000229	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301
929506000230	Coenzyme A binding pocket [chemical binding]; other site
929506000231	PemK-like protein; Region: PemK; pfam02452
929506000232	PemK-like protein; Region: PemK; pfam02452
929506000233	phage tail tape measure protein, TP901 family, core region; Region: tape_meas_TP901; TIGR01760
929506000234	Phage-related minor tail protein; Region: PhageMin_Tail; pfam10145
929506000235	Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093
929506000236	sequence-specific DNA binding site [nucleotide binding]; other site
929506000237	salt bridge; other site
929506000238	RUN domain; Region: RUN; cl02689
929506000239	Protein of unknown function (DUF4065); Region: DUF4065; pfam13274
929506000240	Toxin ToxN, type III toxin-antitoxin system; Region: ToxN_toxin; pfam13958
929506000241	VIP2; A family of actin-ADP-ribosylating toxin. A member of the Bacillus-prodiced vegetative insecticidal proteins (VIPs) possesses high specificity against the major insect pest, corn rootworms, and belongs to a classs of binary toxins and regulators of...; Region: VIP2; cd00233
929506000242	active site
929506000243	conformational flexibility of ligand binding pocket; other site
929506000244	ADP-ribosylating toxin turn-turn motif; other site
929506000245	Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093
929506000246	non-specific DNA binding site [nucleotide binding]; other site
929506000247	salt bridge; other site
929506000248	sequence-specific DNA binding site [nucleotide binding]; other site
929506000249	Peptidoglycan recognition proteins (PGRPs) are pattern recognition receptors that bind, and in certain cases, hydrolyze peptidoglycans (PGNs) of bacterial cell walls. PGRPs have been divided into three classes: short PGRPs (PGRP-S), that are small (20...; Region: PGRP; cd06583
929506000250	amidase catalytic site [active]
929506000251	Zn binding residues [ion binding]; other site
929506000252	substrate binding site [chemical binding]; other site
929506000253	Putative peptidoglycan-binding domain-containing protein [Cell envelope biogenesis, outer membrane]; Region: COG3409
929506000254	Putative peptidoglycan binding domain; Region: PG_binding_1; pfam01471
929506000255	chromosome segregation protein SMC, common bacterial type; Region: SMC_prok_B; TIGR02168
929506000256	Phage regulatory protein Rha (Phage_pRha); Region: Phage_pRha; pfam09669
929506000257	Phage antirepressor protein KilAC domain; Region: ANT; pfam03374
929506000258	Phage regulatory protein Rha (Phage_pRha); Region: Phage_pRha; pfam09669
929506000259	Superfamily of nucleases including Short Patch Repair (Vsr) Endonucleases, archaeal Holliday junction resolvases, MutH methy-directed DNA mismatch-repair endonucleases, and catalytic domains of many restriction endonucleases, such as EcoRI, BamHI, and...; Region: Restriction_endonuclease_like; cl00277
929506000260	putative active site [active]
929506000261	Phage antirepressor protein KilAC domain; Region: ANT; pfam03374
929506000262	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG0675
929506000263	Helix-turn-helix domain; Region: HTH_OrfB_IS605; pfam12323
929506000264	Probable transposase; Region: OrfB_IS605; pfam01385
929506000265	transposase, IS605 OrfB family, central region; Region: tspaseT_teng_C; TIGR01766
929506000266	Predicted site-specific integrase-resolvase [DNA replication, recombination, and repair]; Region: COG2452
929506000267	Helix-Turn-Helix DNA binding domain of transcription regulators from the MerR superfamily; Region: HTH_MerR-SF; cl02600
929506000268	DNA binding residues [nucleotide binding]
929506000269	Serine Recombinase (SR) family, IS607-like transposase subfamily, catalytic domain; members contain a DNA binding domain with homology to MerR/SoxR located N-terminal to the catalytic domain. Serine recombinases catalyze site-specific recombination of...; Region: SR_IS607_transposase_like; cd03769
929506000270	catalytic residues [active]
929506000271	catalytic nucleophile [active]
929506000272	Phage regulatory protein Rha (Phage_pRha); Region: Phage_pRha; cl10713
929506000273	Phage regulatory protein Rha (Phage_pRha); Region: Phage_pRha; pfam09669
929506000274	Integration host factor (IHF) and HU are small heterodimeric members of the DNABII protein family that bind and bend DNA, functioning as architectural factors in many cellular processes including transcription, site-specific recombination, and...; Region: HU_IHF; cd00591
929506000275	IHF - DNA interface [nucleotide binding]; other site
929506000276	IHF dimer interface [polypeptide binding]; other site
929506000277	Phage antirepressor protein KilAC domain; Region: ANT; pfam03374
929506000278	ORF6C domain; Region: ORF6C; pfam10552
929506000279	N-Utilization Substance G (NusG) N-terminal (NGN) domain Superfamily; Region: NGN; cl02766
929506000280	ParB-like nuclease domain; Region: ParB; smart00470
929506000281	Stage 0 sporulation protein J (antagonist of Soj) containing ParB-like nuclease domain [Transcription]; Region: Spo0J; COG1475
929506000282	MerR HTH family regulatory protein; Region: MerR_1; pfam13411
929506000283	Helix-Turn-Helix DNA binding domain of transcription regulators from the MerR superfamily; Region: HTH_MerR-SF; cl02600
929506000284	DNA binding residues [nucleotide binding]
929506000285	Tubulin/FtsZ: Family includes tubulin alpha-, beta-, gamma-, delta-, and epsilon-tubulins as well as FtsZ, all of which are involved in polymer formation. Tubulin is the major component of microtubules, but also exists as a heterodimer and as a curved...; Region: Tubulin_FtsZ; cl10017
929506000286	Tubulin/FtsZ family, GTPase domain; Region: Tubulin; pfam00091
929506000287	nucleotide binding site [chemical binding]; other site
929506000288	Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cl17220
929506000289	Restriction endonuclease; Region: Mrr_cat; pfam04471
929506000290	DNA segregation ATPase FtsK/SpoIIIE and related proteins [Cell division and chromosome partitioning]; Region: FtsK; COG1674
929506000291	FtsK/SpoIIIE family; Region: FtsK_SpoIIIE; pfam01580
929506000292	helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347
929506000293	Transposase, Mutator family; Region: Transposase_mut; pfam00872
929506000294	MULE transposase domain; Region: MULE; pfam10551
929506000295	Putative esterase; Region: Esterase; pfam00756
929506000296	Zinc dependent phospholipase C (alpha toxin); Region: Zn_dep_PLPC; cd11009
929506000297	Zn binding site [ion binding]; other site
929506000298	PLAT (Polycystin-1, Lipoxygenase, Alpha-Toxin) domain or LH2 (Lipoxygenase homology 2)  domain.  It consists of an eight stranded beta-barrel. The domain can be found in various domain architectures, in case of lipoxygenases, alpha toxin, lipases and...; Region: PLAT; cd00113
929506000299	Predicted ATPase [General function prediction only]; Region: COG3910
929506000300	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
929506000301	Walker A/P-loop; other site
929506000302	ATP binding site [chemical binding]; other site
929506000303	Q-loop/lid; other site
929506000304	ABC transporter signature motif; other site
929506000305	Walker B; other site
929506000306	D-loop; other site
929506000307	H-loop/switch region; other site
929506000308	gallidermin-class lantibiotic protection ABC transporter, ATP-binding subunit; Region: galliderm_ABC; TIGR03740
929506000309	ATP-binding cassette domain of the bacitracin-resistance transporter; Region: ABC_BcrA_bacitracin_resist; cd03268
929506000310	Walker A/P-loop; other site
929506000311	ATP binding site [chemical binding]; other site
929506000312	Q-loop/lid; other site
929506000313	ABC transporter signature motif; other site
929506000314	Walker B; other site
929506000315	D-loop; other site
929506000316	H-loop/switch region; other site
929506000317	lantibiotic protection ABC transporter permease subunit, MutE/EpiE family; Region: lanti_perm_MutE; TIGR03732
929506000318	ABC-2 family transporter protein; Region: ABC2_membrane_4; pfam12730
929506000319	lantibiotic protection ABC transporter permease subunit, MutG family; Region: lanti_perm_MutG; TIGR03733
929506000320	ABC-2 family transporter protein; Region: ABC2_membrane_4; pfam12730
929506000321	Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745
929506000322	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
929506000323	active site
929506000324	phosphorylation site [posttranslational modification]
929506000325	intermolecular recognition site; other site
929506000326	dimerization interface [polypeptide binding]; other site
929506000327	Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383
929506000328	DNA binding site [nucleotide binding]
929506000329	Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642
929506000330	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
929506000331	dimer interface [polypeptide binding]; other site
929506000332	phosphorylation site [posttranslational modification]
929506000333	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
929506000334	ATP binding site [chemical binding]; other site
929506000335	Mg2+ binding site [ion binding]; other site
929506000336	G-X-G motif; other site
929506000337	Fic/DOC family; Region: Fic; cl00960
929506000338	Antitoxin Phd_YefM, type II toxin-antitoxin system; Region: PhdYeFM_antitox; pfam02604
929506000339	INT_SG3, DNA breaking-rejoining enzymes, integrase/recombinases subgroup 3, catalytic domain. The CD contains various predicted bacterial and phage integrase/recombinase sequences for which not much experimental characterization is available; Region: INT_SG3_C; cd01186
929506000340	Int/Topo IB signature motif; other site
929506000341	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
929506000342	ATPases associated with a variety of cellular activities; Region: AAA; smart00382
929506000343	Walker A motif; other site
929506000344	ATP binding site [chemical binding]; other site
929506000345	Walker B motif; other site
929506000346	arginine finger; other site
929506000347	Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392
929506000348	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG4584
929506000349	DNA binding site [nucleotide binding]
929506000350	Integrase core domain; Region: rve; pfam00665
929506000351	ATP-binding cassette domain of the bacitracin-resistance transporter; Region: ABC_BcrA_bacitracin_resist; cd03268
929506000352	gallidermin-class lantibiotic protection ABC transporter, ATP-binding subunit; Region: galliderm_ABC; TIGR03740
929506000353	Walker A/P-loop; other site
929506000354	ATP binding site [chemical binding]; other site
929506000355	Q-loop/lid; other site
929506000356	ABC transporter signature motif; other site
929506000357	Walker B; other site
929506000358	D-loop; other site
929506000359	H-loop/switch region; other site
929506000360	site-specific tyrosine recombinase XerC; Reviewed; Region: xerC; PRK00236
929506000361	DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213
929506000362	active site
929506000363	DNA binding site [nucleotide binding]
929506000364	Int/Topo IB signature motif; other site
929506000365	Homeodomain-like domain; Region: HTH_23; pfam13384
929506000366	Sigma factor regulator C-terminal; Region: Sigma_reg_C; pfam13791
929506000367	Stress responsive A/B Barrel Domain; Region: Dabb; pfam07876
929506000368	VIP2; A family of actin-ADP-ribosylating toxin. A member of the Bacillus-prodiced vegetative insecticidal proteins (VIPs) possesses high specificity against the major insect pest, corn rootworms, and belongs to a classs of binary toxins and regulators of...; Region: VIP2; cl00173
929506000369	active site
929506000370	conformational flexibility of ligand binding pocket; other site
929506000371	ADP-ribosylating toxin turn-turn motif; other site
929506000372	VIP2; A family of actin-ADP-ribosylating toxin. A member of the Bacillus-prodiced vegetative insecticidal proteins (VIPs) possesses high specificity against the major insect pest, corn rootworms, and belongs to a classs of binary toxins and regulators of...; Region: VIP2; cd00233
929506000373	active site
929506000374	conformational flexibility of ligand binding pocket; other site
929506000375	ADP-ribosylating toxin turn-turn motif; other site
929506000376	domain in bacterial beta-glucosidases other glycosidases, glycosyltransferases, proteases, amidases, yeast adhesins, and bacterial toxins; Region: PA14; smart00758
929506000377	Clostridial binary toxin B/anthrax toxin PA; Region: Binary_toxB; pfam03495
929506000378	Transposase domain (DUF772); Region: DUF772; pfam05598
929506000379	Transposase DDE domain; Region: DDE_Tnp_1_6; pfam13751
929506000380	Carbohydrate Binding Module 6 (CBM6); appended to several carbohydrate binding enzymes, including several glycoside hydrolase (GH) family 26 mannanase domains; Region: CBM6_mannanase-like; cd04086
929506000381	putative metal binding site [ion binding]; other site
929506000382	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
929506000383	ATP binding site [chemical binding]; other site
929506000384	Mg2+ binding site [ion binding]; other site
929506000385	G-X-G motif; other site
929506000386	Response regulator of the LytR/AlgR family [Transcription / Signal transduction mechanisms]; Region: LytT; COG3279
929506000387	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
929506000388	active site
929506000389	phosphorylation site [posttranslational modification]
929506000390	intermolecular recognition site; other site
929506000391	dimerization interface [polypeptide binding]; other site
929506000392	LytTr DNA-binding domain; Region: LytTR; smart00850
929506000393	Carbohydrate Binding Module 6 (CBM6) and CBM35_like superfamily; Region: CBM6-CBM35-CBM36_like; cl14880
929506000394	metal binding site [ion binding]; metal-binding site
929506000395	Carbohydrate Binding Module family 35 (CBM35); appended mainly to enzymes that bind alpha-D-galactose (CBM35-Gal), including glycoside hydrolase (GH) families GH31 and GH43; Region: CBM35_galactosidase-like; cd04081
929506000396	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3677
929506000397	InsA N-terminal domain; Region: Zn_Tnp_IS1; pfam03811
929506000398	DDE domain; Region: DDE_Tnp_IS240; pfam13610
929506000399	Integrase core domain; Region: rve; pfam00665
929506000400	Integrase core domain; Region: rve_3; pfam13683
929506000401	ABC-type Fe3+ transport system, periplasmic component [Inorganic ion transport and metabolism]; Region: AfuA; COG1840
929506000402	Bacterial extracellular solute-binding protein; Region: SBP_bac_11; pfam13531
929506000403	Protein of unknown function (DUF3919); Region: DUF3919; pfam13057
929506000404	Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745
929506000405	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
929506000406	active site
929506000407	phosphorylation site [posttranslational modification]
929506000408	intermolecular recognition site; other site
929506000409	dimerization interface [polypeptide binding]; other site
929506000410	Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383
929506000411	DNA binding site [nucleotide binding]
929506000412	ATPases involved in chromosome partitioning [Cell division and chromosome partitioning]; Region: Soj; COG1192
929506000413	ParA and ParB of Caulobacter crescentus belong to a conserved family of bacterial proteins implicated in chromosome segregation. ParB binds to DNA sequences adjacent to the origin of replication and localizes to opposite cell poles shortly following the...; Region: ParA; cd02042
929506000414	P-loop; other site
929506000415	Magnesium ion binding site [ion binding]; other site
929506000416	Carboxypeptidase regulatory-like domain; Region: CarboxypepD_reg; pfam13620
929506000417	Carboxypeptidase regulatory-like domain; Region: CarboxypepD_reg; pfam13620
929506000418	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3677
929506000419	InsA N-terminal domain; Region: Zn_Tnp_IS1; pfam03811
929506000420	DDE domain; Region: DDE_Tnp_IS240; pfam13610
929506000421	Integrase core domain; Region: rve; pfam00665
929506000422	Integrase core domain; Region: rve_3; pfam13683
929506000423	ATPases involved in chromosome partitioning [Cell division and chromosome partitioning]; Region: Soj; COG1192
929506000424	ParA and ParB of Caulobacter crescentus belong to a conserved family of bacterial proteins implicated in chromosome segregation. ParB binds to DNA sequences adjacent to the origin of replication and localizes to opposite cell poles shortly following the...; Region: ParA; cd02042
929506000425	P-loop; other site
929506000426	Magnesium ion binding site [ion binding]; other site
929506000427	ParA and ParB of Caulobacter crescentus belong to a conserved family of bacterial proteins implicated in chromosome segregation. ParB binds to DNA sequences adjacent to the origin of replication and localizes to opposite cell poles shortly following the...; Region: ParA; cd02042
929506000428	Magnesium ion binding site [ion binding]; other site
929506000429	This conserved domain belongs to a superfamily including the bleomycin resistance protein, glyoxalase I, and type I ring-cleaving dioxygenases; Region: Glo_EDI_BRP_like_2; cd07253
929506000430	dimer interface [polypeptide binding]; other site
929506000431	Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903
929506000432	metal binding site [ion binding]; metal-binding site
929506000433	ClC sycA-like chloride channel proteins. This ClC family presents in bacteria, where it facilitates acid resistance in acidic soil. Mutation of this gene (sycA) in Rhizobium tropici CIAT899 causes serious deficiencies in nodule development, nodulation...; Region: ClC_sycA_like; cd03682
929506000434	Chloride channel protein EriC [Inorganic ion transport and metabolism]; Region: EriC; COG0038
929506000435	putative Cl- selectivity filter; other site
929506000436	putative pore gating glutamate residue; other site
929506000437	RNA polymerase factor sigma-70; Validated; Region: PRK08295
929506000438	Sigma-70 region 2; Region: Sigma70_r2; pfam04542
929506000439	Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cl17257
929506000440	Protein of unknown function (DUF2762); Region: DUF2762; pfam10960
929506000441	Protein of unknown function (DUF1659); Region: DUF1659; pfam07872
929506000442	Protein of unknown function (DUF2922); Region: DUF2922; pfam11148
929506000443	Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392
929506000444	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG4584
929506000445	DNA binding site [nucleotide binding]
929506000446	Integrase core domain; Region: rve; pfam00665
929506000447	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
929506000448	ATPases associated with a variety of cellular activities; Region: AAA; smart00382
929506000449	Walker A motif; other site
929506000450	ATP binding site [chemical binding]; other site
929506000451	Walker B motif; other site
929506000452	arginine finger; other site
929506000453	RT_G2_intron: Reverse transcriptases (RTs) with group II intron origin. RT transcribes DNA using RNA as template. Proteins in this subfamily are found in bacterial and mitochondrial group II introns. Their most probable ancestor was a retrotransposable...; Region: RT_G2_intron; cd01651
929506000454	Reverse transcriptase (RNA-dependent DNA polymerase); Region: RVT_1; pfam00078
929506000455	putative active site [active]
929506000456	putative NTP binding site [chemical binding]; other site
929506000457	putative nucleic acid binding site [nucleotide binding]; other site
929506000458	Group II intron, maturase-specific domain; Region: GIIM; pfam08388
929506000459	glycerophosphodiester phosphodiesterase; Provisional; Region: glpQ; PRK11143
929506000460	Glycerophosphodiester phosphodiesterase domain of Escherichia coli (GlpQ) and similar proteins; Region: GDPD_EcGlpQ_like; cd08600
929506000461	active site
929506000462	catalytic site [active]
929506000463	metal binding site [ion binding]; metal-binding site
929506000464	Superoxide dismutase [Inorganic ion transport and metabolism]; Region: SodA; COG0605
929506000465	Iron/manganese superoxide dismutases, C-terminal domain; Region: Sod_Fe_C; pfam02777
929506000466	Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396
929506000467	Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093
929506000468	non-specific DNA binding site [nucleotide binding]; other site
929506000469	salt bridge; other site
929506000470	sequence-specific DNA binding site [nucleotide binding]; other site
929506000471	Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396
929506000472	Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093
929506000473	non-specific DNA binding site [nucleotide binding]; other site
929506000474	salt bridge; other site
929506000475	sequence-specific DNA binding site [nucleotide binding]; other site
929506000476	Sigma-70 region 2; Region: Sigma70_r2; pfam04542
929506000477	RNA polymerase sigma factor, sigma-70 family; Region: sigma70-ECF; TIGR02937
929506000478	Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171
929506000479	DNA binding residues [nucleotide binding]
929506000480	Early set domain associated with the catalytic domain of sugar utilizing enzymes at either the N or C terminus; Region: E_set; cl09101
929506000481	Site-specific recombinases, DNA invertase Pin homologs [DNA replication, recombination, and repair]; Region: PinR; COG1961
929506000482	Serine Recombinase (SR) family, Resolvase and Invertase subfamily, catalytic domain; members contain a C-terminal DNA binding domain. Serine recombinases catalyze site-specific recombination of DNA molecules by a concerted, four-strand cleavage and...; Region: SR_ResInv; cd03768
929506000483	catalytic residues [active]
929506000484	catalytic nucleophile [active]
929506000485	Presynaptic Site I dimer interface [polypeptide binding]; other site
929506000486	Synaptic Antiparallel dimer interface [polypeptide binding]; other site
929506000487	Synaptic Flat tetramer interface [polypeptide binding]; other site
929506000488	Synaptic Site I dimer interface [polypeptide binding]; other site
929506000489	DNA binding site [nucleotide binding]
929506000490	Clostridium epsilon toxin ETX/Bacillus mosquitocidal toxin MTX2; Region: ETX_MTX2; pfam03318
929506000491	Clostridium epsilon toxin ETX/Bacillus mosquitocidal toxin MTX2; Region: ETX_MTX2; pfam03318
929506000492	50S ribosomal protein L34; Reviewed; Region: rpmH; PRK00399
929506000493	ribonuclease P; Reviewed; Region: rnpA; PRK00499
929506000494	Haemolytic domain; Region: Haemolytic; pfam01809
929506000495	60Kd inner membrane protein; Region: 60KD_IMP; cl00489
929506000496	Preprotein translocase subunit YidC [Intracellular trafficking and secretion]; Region: YidC; COG0706
929506000497	Predicted RNA-binding protein [General function prediction only]; Region: Jag; COG1847
929506000498	jag_K homology RNA-binding domain. The KH domain is found in proteins homologous to the Bacillus subtilis protein Jag, which is associated with SpoIIIJ and is necessary for the third stage of sporulation.  The KH motif is a beta-alpha-alpha-beta-beta...; Region: jag_KH; cd02414
929506000499	G-X-X-G motif; other site
929506000500	R3H domain found in proteins homologous to Bacillus subtilus Jag, which is associated with SpoIIIJ. SpoIIIJ is necessary for the third stage of sporulation. The name of the R3H domain comes from the characteristic spacing of the most conserved arginine...; Region: R3H_jag; cd02644
929506000501	RxxxH motif; other site
929506000502	tRNA modification GTPase TrmE; Reviewed; Region: trmE; PRK05291
929506000503	GTP-binding protein TrmE N-terminus; Region: TrmE_N; pfam10396
929506000504	trmE is a tRNA modification GTPase; Region: trmE; cd04164
929506000505	G1 box; other site
929506000506	GTP/Mg2+ binding site [chemical binding]; other site
929506000507	Switch I region; other site
929506000508	G2 box; other site
929506000509	Switch II region; other site
929506000510	G3 box; other site
929506000511	G4 box; other site
929506000512	G5 box; other site
929506000513	Catalytic cysteine-containing C-terminus of GTPase, MnmE; Region: GTPase_Cys_C; pfam12631
929506000514	tRNA uridine 5-carboxymethylaminomethyl modification enzyme GidA; Validated; Region: PRK05192
929506000515	tRNA (uracil-5-)-methyltransferase Gid; Reviewed; Region: PRK05335
929506000516	tRNA (uracil-5-)-methyltransferase Gid; Reviewed; Region: PRK05335
929506000517	GidA associated domain 3; Region: GIDA_assoc_3; pfam13932
929506000518	Predicted S-adenosylmethionine-dependent methyltransferase involved in bacterial cell division [Cell envelope biogenesis, outer membrane]; Region: GidB; COG0357
929506000519	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
929506000520	S-adenosylmethionine binding site [chemical binding]; other site
929506000521	nucleoid occlusion protein; Region: nucleoid_noc; TIGR04285
929506000522	ParB-like nuclease domain; Region: ParBc; pfam02195
929506000523	ATPases involved in chromosome partitioning [Cell division and chromosome partitioning]; Region: Soj; COG1192
929506000524	ParA and ParB of Caulobacter crescentus belong to a conserved family of bacterial proteins implicated in chromosome segregation. ParB binds to DNA sequences adjacent to the origin of replication and localizes to opposite cell poles shortly following the...; Region: ParA; cd02042
929506000525	P-loop; other site
929506000526	Magnesium ion binding site [ion binding]; other site
929506000527	ParA and ParB of Caulobacter crescentus belong to a conserved family of bacterial proteins implicated in chromosome segregation. ParB binds to DNA sequences adjacent to the origin of replication and localizes to opposite cell poles shortly following the...; Region: ParA; cd02042
929506000528	Magnesium ion binding site [ion binding]; other site
929506000529	ParB/RepB/Spo0J family partition protein; Region: parB_part; TIGR00180
929506000530	ParB-like nuclease domain; Region: ParB; smart00470
929506000531	Protein of unknown function (DUF1256); Region: DUF1256; cl06087
929506000532	LysE type translocator; Region: LysE; cl00565
929506000533	Bacterial protein of unknown function (DUF951); Region: DUF951; pfam06107
929506000534	30S ribosomal protein S6; Reviewed; Region: rpsF; PRK00453
929506000535	Single-stranded DNA-binding protein [DNA replication, recombination, and repair]; Region: Ssb; COG0629
929506000536	SSB_OBF: A subfamily of OB folds similar to the OB fold of ssDNA-binding protein (SSB). SSBs bind with high affinity to ssDNA. They bind to and protect ssDNA intermediates during DNA metabolic pathways. All bacterial and eukaryotic SSBs studied to date...; Region: SSB_OBF; cd04496
929506000537	dimer interface [polypeptide binding]; other site
929506000538	ssDNA binding site [nucleotide binding]; other site
929506000539	tetramer (dimer of dimers) interface [polypeptide binding]; other site
929506000540	30S ribosomal protein S18; Reviewed; Region: rpsR; PRK00391
929506000541	MazG-like family; Region: MazG-like; pfam12643
929506000542	Predicted membrane protein (DUF2232); Region: DUF2232; pfam09991
929506000543	Predicted signaling protein consisting of a modified GGDEF domain and a DHH domain [Signal transduction mechanisms]; Region: COG3887
929506000544	Class III nucleotidyl cyclases; Region: Nucleotidyl_cyc_III; cl11967
929506000545	DHH family; Region: DHH; pfam01368
929506000546	DHHA1 domain; Region: DHHA1; pfam02272
929506000547	50S ribosomal protein L9; Reviewed; Region: rplI; PRK00137
929506000548	Ribosomal protein L9, N-terminal domain; Region: Ribosomal_L9_N; pfam01281
929506000549	Ribosomal protein L9, C-terminal domain; Region: Ribosomal_L9_C; pfam03948
929506000550	ATP-dependent protease, Lon family; Region: spore_lon_C; TIGR02903
929506000551	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
929506000552	Walker A motif; other site
929506000553	ATP binding site [chemical binding]; other site
929506000554	Walker B motif; other site
929506000555	arginine finger; other site
929506000556	Lon protease (S16) C-terminal proteolytic domain; Region: Lon_C; pfam05362
929506000557	replicative DNA helicase; Provisional; Region: PRK05595
929506000558	DnaB-like helicase N terminal domain; Region: DnaB; pfam00772
929506000559	DnaB helicase C terminal domain. The hexameric helicase DnaB unwinds the DNA duplex at the  chromosome replication fork. Although the mechanism by which DnaB both couples ATP hydrolysis to translocation along DNA and denatures the duplex is unknown, a...; Region: DnaB_C; cd00984
929506000560	Walker A motif; other site
929506000561	ATP binding site [chemical binding]; other site
929506000562	Walker B motif; other site
929506000563	DNA binding loops [nucleotide binding]
929506000564	Molecular chaperone (small heat shock protein) [Posttranslational modification, protein turnover, chaperones]; Region: IbpA; COG0071
929506000565	alpha-crystallin domain (ACD) found in alpha-crystallin-type small heat shock proteins, and a similar domain found in p23 (a cochaperone for Hsp90) and in other p23-like proteins; Region: alpha-crystallin-Hsps_p23-like; cl00175
929506000566	EDD domain protein, DegV family; Region: DegV; TIGR00762
929506000567	Uncharacterized protein, DegV family COG1307; Region: DegV; pfam02645
929506000568	EDD domain protein, DegV family; Region: DegV; TIGR00762
929506000569	Uncharacterized protein, DegV family COG1307; Region: DegV; pfam02645
929506000570	homoserine dehydrogenase; Provisional; Region: PRK06349
929506000571	Homoserine dehydrogenase, NAD binding domain; Region: NAD_binding_3; pfam03447
929506000572	Homoserine dehydrogenase; Region: Homoserine_dh; pfam00742
929506000573	ACT_HSDH_Hom CD includes the C-terminal ACT domain of the NAD(P)H-dependent, homoserine dehydrogenase (HSDH) and related domains; Region: ACT_HSDH-Hom; cd04881
929506000574	Threonine synthase catalyzes the final step of threonine biosynthesis. The conversion of O-phosphohomoserine into threonine and inorganic phosphate is pyridoxal 5'-phosphate dependent. The Thr-synth_1 CD includes members from higher plants; Region: Thr-synth_2; cd01560
929506000575	Threonine synthase [Amino acid transport and metabolism]; Region: ThrC; COG0498
929506000576	pyridoxal 5'-phosphate binding site [chemical binding]; other site
929506000577	catalytic residue [active]
929506000578	bifunctional biotin--[acetyl-CoA-carboxylase] synthetase/biotin operon repressor; Provisional; Region: PRK11886
929506000579	Biotin operon repressor [Transcription]; Region: BirA; COG1654
929506000580	Biotin/lipoate A/B protein ligase family; Region: BPL_LplA_LipB; pfam03099
929506000581	Biotin protein ligase C terminal domain; Region: BPL_C; pfam02237
929506000582	Protein of unknown function (DUF3006); Region: DUF3006; pfam11213
929506000583	Gamma-glutamyl phosphate reductase (GPR), aldehyde dehydrogenase families 18 and 19; Region: ALDH_F18-19_ProA-GPR; cd07079
929506000584	gamma-glutamyl phosphate reductase; Region: proA; TIGR00407
929506000585	putative catalytic cysteine [active]
929506000586	gamma-glutamyl kinase; Provisional; Region: PRK05429
929506000587	AAK_G5K_ProB: Glutamate-5-kinase (G5K) catalyzes glutamate-dependent ATP cleavage; G5K transfers the terminal phosphoryl group of ATP to the gamma-carboxyl group of glutamate, in the first and controlling step of proline (and, in mammals, ornithine)...; Region: AAK_G5K_ProB; cd04242
929506000588	nucleotide binding site [chemical binding]; other site
929506000589	homotetrameric interface [polypeptide binding]; other site
929506000590	putative phosphate binding site [ion binding]; other site
929506000591	putative allosteric binding site; other site
929506000592	PUA domain; Region: PUA; pfam01472
929506000593	NADP oxidoreductase coenzyme F420-dependent; Region: F420_oxidored; cl17232
929506000594	pyrroline-5-carboxylate reductase; Reviewed; Region: PRK11880
929506000595	Uncharacterized FAD-dependent dehydrogenases [General function prediction only]; Region: COG2509
929506000596	lycopene cyclase; Region: lycopene_cycl; TIGR01789
929506000597	Adenylosuccinate synthetase (AdSS) catalyzes the first step in the de novo biosynthesis of AMP. IMP and L-aspartate are conjugated in a two-step reaction accompanied by the hydrolysis of GTP to GDP in the presence of Mg2+. In the first step, the...; Region: AdSS; cd03108
929506000598	Adenylosuccinate synthetase; Region: Adenylsucc_synt; smart00788
929506000599	GDP-binding site [chemical binding]; other site
929506000600	ACT binding site; other site
929506000601	IMP binding site; other site
929506000602	hybrid cluster protein-associated redox disulfide domain; Region: prismane_assoc; TIGR03980
929506000603	Acyl-ACP thioesterase; Region: Acyl-ACP_TE; pfam01643
929506000604	4-hydroxybenzoyl-CoA thioesterase (4HBT). Catalyzes the final step in the 4-chlorobenzoate degradation pathway in which 4-chlorobenzoate is converted to 4-hydroxybenzoate in certain soil-dwelling bacteria. 4HBT forms a homotetramer with four active sites; Region: 4HBT; cd00586
929506000605	active site
929506000606	4-hydroxybenzoyl-CoA thioesterase (4HBT). Catalyzes the final step in the 4-chlorobenzoate degradation pathway in which 4-chlorobenzoate is converted to 4-hydroxybenzoate in certain soil-dwelling bacteria. 4HBT forms a homotetramer with four active sites; Region: 4HBT; cd00586
929506000607	active site
929506000608	flavoprotein, HI0933 family; Region: TIGR00275
929506000609	Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070
929506000610	DNA replication protein DnaC; Validated; Region: PRK06835
929506000611	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
929506000612	Walker A motif; other site
929506000613	ATP binding site [chemical binding]; other site
929506000614	Replication initiation and membrane attachment; Region: DnaB_2; pfam07261
929506000615	Replication initiation and membrane attachment; Region: DnaB_2; cl12121
929506000616	Predicted ATPase of the ABC class; Region: ABC_ATPase; pfam09818
929506000617	Transcriptional regulators [Transcription]; Region: MarR; COG1846
929506000618	MarR family; Region: MarR_2; pfam12802
929506000619	3-oxoacyl-(acyl carrier protein) synthase III; Reviewed; Region: PRK09352
929506000620	Ketoacyl-acyl carrier protein synthase III (KASIII) initiates the elongation in type II fatty acid synthase systems. It is found in bacteria and plants. Elongation of fatty acids in the type II systems occurs by Claisen condensation of malonyl-acyl...; Region: KAS_III; cd00830
929506000621	dimer interface [polypeptide binding]; other site
929506000622	active site
929506000623	CoA binding pocket [chemical binding]; other site
929506000624	acyl carrier protein; Provisional; Region: acpP; PRK00982
929506000625	putative enoyl-[acyl-carrier-protein] reductase II; Region: enACPred_II; TIGR03151
929506000626	2-Nitropropane dioxygenase (NPD), one of the nitroalkane oxidizing enzyme families, catalyzes oxidative denitrification of nitroalkanes to their corresponding carbonyl compounds and nitrites. NDP is a member of the NAD(P)H-dependent flavin oxidoreductase...; Region: NPD_like; cd04730
929506000627	FMN binding site [chemical binding]; other site
929506000628	substrate binding site [chemical binding]; other site
929506000629	putative catalytic residue [active]
929506000630	(acyl-carrier-protein) S-malonyltransferase [Lipid metabolism]; Region: FabD; COG0331
929506000631	malonyl CoA-acyl carrier protein transacylase; Region: fabD; TIGR00128
929506000632	3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05557
929506000633	beta-Keto acyl carrier protein reductase (BKR), involved in Type II FAS, classical (c) SDRs; Region: BKR_SDR_c; cd05333
929506000634	NAD(P) binding site [chemical binding]; other site
929506000635	homotetramer interface [polypeptide binding]; other site
929506000636	homodimer interface [polypeptide binding]; other site
929506000637	active site
929506000638	beta-ketoacyl-acyl-carrier-protein synthase II; Region: fabF; TIGR03150
929506000639	Beta-ketoacyl-acyl carrier protein (ACP) synthase (KAS), type I and II. KASs are responsible for the elongation steps in fatty acid biosynthesis. KASIII catalyses the initial condensation and KAS I and II catalyze further elongation steps by Claisen...; Region: KAS_I_II; cd00834
929506000640	dimer interface [polypeptide binding]; other site
929506000641	active site
929506000642	acetyl-CoA carboxylase biotin carboxyl carrier protein subunit; Validated; Region: PRK06302
929506000643	The biotinyl-domain or biotin carboxyl carrier protein (BCCP) domain is present in all biotin-dependent enzymes, such as acetyl-CoA carboxylase, pyruvate carboxylase, propionyl-CoA carboxylase, methylcrotonyl-CoA carboxylase, geranyl-CoA carboxylase; Region: biotinyl_domain; cd06850
929506000644	carboxyltransferase (CT) interaction site; other site
929506000645	biotinylation site [posttranslational modification]; other site
929506000646	FabZ is a 17kD beta-hydroxyacyl-acyl carrier protein (ACP) dehydratase that primarily catalyzes the dehydration of beta-hydroxyacyl-ACP to trans-2-acyl-ACP, the third step in the elongation phase of the bacterial/ plastid, type II, fatty-acid...; Region: FabZ; cd01288
929506000647	biotin carboxylase; Validated; Region: PRK05586
929506000648	Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289
929506000649	ATP-grasp domain; Region: ATP-grasp_4; cl17255
929506000650	Biotin carboxylase C-terminal domain; Region: Biotin_carb_C; smart00878
929506000651	Acetyl-CoA carboxylase beta subunit [Lipid metabolism]; Region: AccD; COG0777
929506000652	malonate decarboxylase subunit beta; Reviewed; Region: PRK07189; cl17682
929506000653	acetyl-CoA carboxylase carboxyltransferase subunit alpha; Validated; Region: PRK05724
929506000654	acetyl-CoA carboxylase carboxyltransferase alpha subunit; Provisional; Region: accA; CHL00198
929506000655	Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of  substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134
929506000656	Bacterial extracellular solute-binding proteins, family 3; Region: SBP_bac_3; pfam00497
929506000657	substrate binding pocket [chemical binding]; other site
929506000658	membrane-bound complex binding site; other site
929506000659	hinge residues; other site
929506000660	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
929506000661	dimer interface [polypeptide binding]; other site
929506000662	conserved gate region; other site
929506000663	putative PBP binding loops; other site
929506000664	ABC-ATPase subunit interface; other site
929506000665	ABC-type polar amino acid transport system, ATPase component [Amino acid transport and metabolism]; Region: GlnQ; COG1126
929506000666	ATP-binding cassette domain of the histidine and glutamine transporters; Region: ABC_HisP_GlnQ; cd03262
929506000667	Walker A/P-loop; other site
929506000668	ATP binding site [chemical binding]; other site
929506000669	Q-loop/lid; other site
929506000670	ABC transporter signature motif; other site
929506000671	Walker B; other site
929506000672	D-loop; other site
929506000673	H-loop/switch region; other site
929506000674	Leukocidin/Hemolysin toxin family; Region: Leukocidin; cl08468
929506000675	Putative amidase domain; Region: Amidase_6; pfam12671
929506000676	Rad3-related DNA helicases [Transcription / DNA replication, recombination, and repair]; Region: DinG; COG1199
929506000677	DEAD_2; Region: DEAD_2; pfam06733
929506000678	Helicase C-terminal domain; Region: Helicase_C_2; pfam13307
929506000679	competence damage-inducible protein A; Provisional; Region: PRK00549
929506000680	Competence-damaged protein. CinA is the first gene in the competence- inducible (cin) operon and is thought to be specifically required at some stage in the process of transformation. This domain is closely related to a domain, found in a variety of...; Region: cinA; cd00885
929506000681	putative MPT binding site; other site
929506000682	Competence-damaged protein; Region: CinA; pfam02464
929506000683	Sodium:dicarboxylate symporter family; Region: SDF; pfam00375
929506000684	Na+/H+-dicarboxylate symporters [Energy production and conversion]; Region: GltP; COG1301
929506000685	Peptidase domain in the S8 and S53 families; Region: Peptidases_S8_S53; cl10459
929506000686	active site
929506000687	catalytic residues [active]
929506000688	Protein of unknown function, DUF606; Region: DUF606; pfam04657
929506000689	dUTPase; Region: dUTPase_2; pfam08761
929506000690	Nucleoside Triphosphate Pyrophosphohydrolase (EC 3.6.1.8) MazG-like domain found in dimeric 2-Deoxyuridine 5'-triphosphate nucleotidohydrolase and similar proteins; Region: NTP-PPase_dUTPase; cd11527
929506000691	active site
929506000692	homodimer interface [polypeptide binding]; other site
929506000693	metal binding site [ion binding]; metal-binding site
929506000694	Nucleoside Triphosphate Pyrophosphohydrolase (EC 3.6.1.8) MazG-like domain superfamily; Region: NTP-PPase; cl16941
929506000695	UDP-N-acetylglucosamine 1-carboxyvinyltransferase; Region: murA; TIGR01072
929506000696	UDP-N-acetylglucosamine enolpyruvyl transferase catalyzes enolpyruvyl transfer as part of the first step in the biosynthesis of peptidoglycan, a component of the bacterial cell wall. The reaction is phosphoenolpyruvate + UDP-N-acetyl-D-glucosamine =...; Region: UdpNAET; cd01555
929506000697	hinge; other site
929506000698	active site
929506000699	Metal-dependent hydrolases of the beta-lactamase superfamily I [General function prediction only]; Region: PhnP; COG1235
929506000700	Sporulation and spore germination; Region: Germane; smart00909
929506000701	hypothetical protein; Provisional; Region: PRK05590
929506000702	Response regulator receiver domain; Region: Response_reg; pfam00072
929506000703	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
929506000704	active site
929506000705	phosphorylation site [posttranslational modification]
929506000706	intermolecular recognition site; other site
929506000707	dimerization interface [polypeptide binding]; other site
929506000708	rRNA large subunit methyltransferase; Provisional; Region: PRK00103
929506000709	Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642
929506000710	Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225
929506000711	dimerization interface [polypeptide binding]; other site
929506000712	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
929506000713	dimer interface [polypeptide binding]; other site
929506000714	phosphorylation site [posttranslational modification]
929506000715	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
929506000716	ATP binding site [chemical binding]; other site
929506000717	Mg2+ binding site [ion binding]; other site
929506000718	G-X-G motif; other site
929506000719	Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745
929506000720	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
929506000721	active site
929506000722	phosphorylation site [posttranslational modification]
929506000723	intermolecular recognition site; other site
929506000724	dimerization interface [polypeptide binding]; other site
929506000725	Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383
929506000726	DNA binding site [nucleotide binding]
929506000727	Asparagine synthase (glutamine-hydrolyzing) [Amino acid transport and metabolism]; Region: AsnB; COG0367
929506000728	Glutamine amidotransferases class-II (GATase) asparagine synthase_B type.  Asparagine synthetase B catalyses the ATP-dependent conversion of aspartate to asparagine. This enzyme is a homodimer, with each monomer composed of a  glutaminase domain and a...; Region: AsnB; cd00712
929506000729	active site
929506000730	dimer interface [polypeptide binding]; other site
929506000731	The C-terminal domain of Asparagine Synthase B. This domain is always found associated n-terminal amidotransferase domain. Family members that contain this domain catalyse the conversion of aspartate to asparagine. Asparagine synthetase B  catalyzes the...; Region: Asn_Synthase_B_C; cd01991
929506000732	Ligand Binding Site [chemical binding]; other site
929506000733	Molecular Tunnel; other site
929506000734	Acetyltransferase (isoleucine patch superfamily) [General function prediction only]; Region: WbbJ; COG0110
929506000735	Maltose O-acyltransferase (MAT)-like: This family is composed of maltose O-acetyltransferase, galactoside O-acetyltransferase (GAT), xenobiotic acyltransferase (XAT) and similar proteins. MAT and GAT catalyze the CoA-dependent acetylation of the...; Region: LbH_MAT_like; cd04647
929506000736	trimer interface [polypeptide binding]; other site
929506000737	active site
929506000738	substrate binding site [chemical binding]; other site
929506000739	CoA binding site [chemical binding]; other site
929506000740	Cache domain; Region: Cache_1; pfam02743
929506000741	Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225
929506000742	dimerization interface [polypeptide binding]; other site
929506000743	Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer); Region: MA; smart00283
929506000744	Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386
929506000745	dimer interface [polypeptide binding]; other site
929506000746	putative CheW interface [polypeptide binding]; other site
929506000747	Uncharacterized Zn-ribbon-containing protein involved in phosphonate metabolism [Inorganic ion transport and metabolism]; Region: PhnA; COG2824
929506000748	PhnA Zinc-Ribbon; Region: PhnA_Zn_Ribbon; pfam08274
929506000749	PhnA protein; Region: PhnA; pfam03831
929506000750	Transcriptional regulators [Transcription]; Region: PurR; COG1609
929506000751	Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392
929506000752	DNA binding site [nucleotide binding]
929506000753	domain linker motif; other site
929506000754	Ligand binding domain of the LacI tanscriptional regulator family belonging to the type I periplasmic-binding fold protein superfamily; Region: PBP1_LacI_sugar_binding_like; cd06267
929506000755	ligand binding site [chemical binding]; other site
929506000756	dimerization interface [polypeptide binding]; other site
929506000757	glycerol-3-phosphate transporter ATP-binding subunit; Provisional; Region: ugpC; PRK11650
929506000758	The N-terminal ATPase domain of the maltose transporter, MalK; Region: ABC_MalK_N; cd03301
929506000759	Walker A/P-loop; other site
929506000760	ATP binding site [chemical binding]; other site
929506000761	Q-loop/lid; other site
929506000762	ABC transporter signature motif; other site
929506000763	Walker B; other site
929506000764	D-loop; other site
929506000765	H-loop/switch region; other site
929506000766	ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653
929506000767	ABC-type polysaccharide transport system, permease component [Carbohydrate transport and metabolism]; Region: LplB; COG4209
929506000768	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
929506000769	dimer interface [polypeptide binding]; other site
929506000770	conserved gate region; other site
929506000771	putative PBP binding loops; other site
929506000772	ABC-ATPase subunit interface; other site
929506000773	ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395
929506000774	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
929506000775	dimer interface [polypeptide binding]; other site
929506000776	conserved gate region; other site
929506000777	putative PBP binding loops; other site
929506000778	ABC-ATPase subunit interface; other site
929506000779	Alpha-glucosidases, family 31 of glycosyl hydrolases [Carbohydrate transport and metabolism]; Region: COG1501
929506000780	Galactose mutarotase-like; Region: Gal_mutarotas_2; pfam13802
929506000781	Alpha-glucosidase II (alpha-D-glucoside glucohydrolase) is a glycosyl hydrolase family 31 (GH31) enzyme, found in bacteria and plants, which has exo-alpha-1,4-glucosidase and oligo-1,6-glucosidase activities. Alpha-glucosidase II has been characterized...; Region: GH31_glucosidase_II_MalA; cd06604
929506000782	trimer interface [polypeptide binding]; other site
929506000783	active site
929506000784	homohexamer (dimer of homotrimer) interface [polypeptide binding]; other site
929506000785	catalytic site [active]
929506000786	4-alpha-glucanotransferase; Provisional; Region: PRK14508
929506000787	This is a family of oligosaccharide phosphorylases. It includes yeast and mammalian glycogen phosphorylases, plant starch/glucan phosphorylase, as well as the maltodextrin phosphorylases of bacteria. The members of this family catalyze the breakdown of...; Region: GT1_Glycogen_Phosphorylase; cd04300
929506000788	homodimer interface [polypeptide binding]; other site
929506000789	glycogen/starch/alpha-glucan phosphorylases; Region: P_ylase; TIGR02093
929506000790	active site pocket [active]
929506000791	Transposase domain (DUF772); Region: DUF772; pfam05598
929506000792	Transposase DDE domain; Region: DDE_Tnp_1_6; pfam13751
929506000793	50S ribosomal protein L25/general stress protein Ctc; Reviewed; Region: PRK05618
929506000794	Ribosomal L25/TL5/CTC N-terminal 5S rRNA binding domain; Region: Ribosomal_L25_TL5_CTC; cd00495
929506000795	5S rRNA interface [nucleotide binding]; other site
929506000796	CTC domain interface [polypeptide binding]; other site
929506000797	L16 interface [polypeptide binding]; other site
929506000798	Protein tyrosine phosphatases (PTP) catalyze the dephosphorylation of phosphotyrosine peptides; they regulate phosphotyrosine levels in signal transduction pathways. The depth of the active site cleft renders the enzyme specific for phosphorylated Tyr; Region: PTPc; cl00053
929506000799	FtsX-like permease family; Region: FtsX; pfam02687
929506000800	ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255
929506000801	ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136
929506000802	Walker A/P-loop; other site
929506000803	ATP binding site [chemical binding]; other site
929506000804	Q-loop/lid; other site
929506000805	ABC transporter signature motif; other site
929506000806	Walker B; other site
929506000807	D-loop; other site
929506000808	H-loop/switch region; other site
929506000809	Nitrite/Sulfite reductase ferredoxin-like half domain; Region: NIR_SIR_ferr; pfam03460
929506000810	Nitrite and sulphite reductase 4Fe-4S domain; Region: NIR_SIR; pfam01077
929506000811	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
929506000812	Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745
929506000813	active site
929506000814	phosphorylation site [posttranslational modification]
929506000815	intermolecular recognition site; other site
929506000816	dimerization interface [polypeptide binding]; other site
929506000817	Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383
929506000818	DNA binding site [nucleotide binding]
929506000819	Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642
929506000820	Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225
929506000821	dimerization interface [polypeptide binding]; other site
929506000822	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
929506000823	dimer interface [polypeptide binding]; other site
929506000824	phosphorylation site [posttranslational modification]
929506000825	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
929506000826	ATP binding site [chemical binding]; other site
929506000827	Mg2+ binding site [ion binding]; other site
929506000828	G-X-G motif; other site
929506000829	CAAX protease self-immunity; Region: Abi; pfam02517
929506000830	2-hydroxyacid dehydrogenase; Provisional; Region: PRK08410
929506000831	Putative D-isomer specific 2-hydroxyacid dehydrogenases; Region: 2-Hacid_dh_4; cd12162
929506000832	putative ligand binding site [chemical binding]; other site
929506000833	putative NAD binding site [chemical binding]; other site
929506000834	catalytic site [active]
929506000835	Carboxypeptidase regulatory-like domain; Region: CarboxypepD_reg; pfam13620
929506000836	Carboxypeptidase regulatory-like domain; Region: CarboxypepD_reg; pfam13620
929506000837	Carboxypeptidase regulatory-like domain; Region: CarboxypepD_reg; pfam13620
929506000838	Carbohydrate Binding Module family 35 (CBM35); appended mainly to enzymes that bind alpha-D-galactose (CBM35-Gal), including glycoside hydrolase (GH) families GH31 and GH43; Region: CBM35_galactosidase-like; cd04081
929506000839	Ca binding site [ion binding]; other site
929506000840	Carbohydrate Binding Module 6 (CBM6) and CBM35_like superfamily; Region: CBM6-CBM35-CBM36_like; cl14880
929506000841	Carboxypeptidase regulatory-like domain; Region: CarboxypepD_reg; pfam13620
929506000842	Carbohydrate Binding Module family 35 (CBM35); appended mainly to enzymes that bind alpha-D-galactose (CBM35-Gal), including glycoside hydrolase (GH) families GH31 and GH43; Region: CBM35_galactosidase-like; cd04081
929506000843	Ca binding site [ion binding]; other site
929506000844	Sugar diacid utilization regulator [Transcription / Signal transduction mechanisms]; Region: CdaR; COG3835
929506000845	Putative sugar diacid recognition; Region: Diacid_rec; pfam05651
929506000846	PucR C-terminal helix-turn-helix domain; Region: HTH_30; pfam13556
929506000847	H+/gluconate symporter and related permeases [Carbohydrate transport and metabolism / Amino acid transport and metabolism]; Region: GntT; COG2610
929506000848	Na+-H+ antiporter family; Region: Na_H_antiport_2; pfam13726
929506000849	InsA N-terminal domain; Region: Zn_Tnp_IS1; pfam03811
929506000850	DDE domain; Region: DDE_Tnp_IS240; pfam13610
929506000851	Integrase core domain; Region: rve; pfam00665
929506000852	Integrase core domain; Region: rve_3; pfam13683
929506000853	Glycerate kinase [Carbohydrate transport and metabolism]; Region: COG1929
929506000854	Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077
929506000855	Zn2+ binding site [ion binding]; other site
929506000856	Mg2+ binding site [ion binding]; other site
929506000857	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
929506000858	PAS domain; Region: PAS_9; pfam13426
929506000859	putative active site [active]
929506000860	heme pocket [chemical binding]; other site
929506000861	Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949
929506000862	metal binding site [ion binding]; metal-binding site
929506000863	active site
929506000864	I-site; other site
929506000865	EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2).  The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948
929506000866	Mn-containing catalase [Inorganic ion transport and metabolism]; Region: COG3546
929506000867	dinuclear metal binding motif [ion binding]; other site
929506000868	CotJB protein; Region: CotJB; pfam12652
929506000869	Spore coat associated protein JA (CotJA); Region: CotJA; pfam11007
929506000870	Domain of unknown function (DUF4396); Region: DUF4396; pfam14342
929506000871	Putative cell wall binding repeat 2; Region: CW_binding_2; pfam04122
929506000872	Putative cell wall binding repeat 2; Region: CW_binding_2; pfam04122
929506000873	Transposase domain (DUF772); Region: DUF772; pfam05598
929506000874	Transposase DDE domain; Region: DDE_Tnp_1_6; pfam13751
929506000875	Protein of unknown function (DUF1657); Region: DUF1657; pfam07870
929506000876	Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093
929506000877	non-specific DNA binding site [nucleotide binding]; other site
929506000878	salt bridge; other site
929506000879	sequence-specific DNA binding site [nucleotide binding]; other site
929506000880	helicase 45; Provisional; Region: PTZ00424
929506000881	DEAD-box helicases. A diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker  B motif; Region: DEADc; cd00268
929506000882	ATP binding site [chemical binding]; other site
929506000883	Mg++ binding site [ion binding]; other site
929506000884	motif III; other site
929506000885	Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079
929506000886	nucleotide binding region [chemical binding]; other site
929506000887	ATP-binding site [chemical binding]; other site
929506000888	RNA recognition motif in the DbpA subfamily of prokaryotic DEAD-box rRNA helicases; Region: RRM_DbpA; cd12252
929506000889	RNA binding site [nucleotide binding]; other site
929506000890	c-di-GMP phosphodiesterase class II (HD-GYP domain) [Signal transduction mechanisms]; Region: COG2206
929506000891	Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077
929506000892	Zn2+ binding site [ion binding]; other site
929506000893	Mg2+ binding site [ion binding]; other site
929506000894	Heme NO binding; Region: HNOB; pfam07700
929506000895	Methyl-accepting chemotaxis protein [Cell motility and secretion / Signal transduction mechanisms]; Region: Tar; COG0840
929506000896	Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386
929506000897	dimer interface [polypeptide binding]; other site
929506000898	putative CheW interface [polypeptide binding]; other site
929506000899	Radical SAM superfamily; Region: Radical_SAM; pfam04055
929506000900	Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335
929506000901	FeS/SAM binding site; other site
929506000902	Uncharacterized membrane protein [Function unknown]; Region: COG3949
929506000903	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3677
929506000904	InsA N-terminal domain; Region: Zn_Tnp_IS1; pfam03811
929506000905	DDE domain; Region: DDE_Tnp_IS240; pfam13610
929506000906	Integrase core domain; Region: rve; pfam00665
929506000907	Integrase core domain; Region: rve_3; pfam13683
929506000908	Predicted Fe-S oxidoreductase [General function prediction only]; Region: COG1242
929506000909	haloacid dehalogenase-like hydrolase; Region: Hydrolase; pfam00702
929506000910	haloacid dehalogenase-like hydrolase; Region: HAD; cl17202
929506000911	Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427
929506000912	motif II; other site
929506000913	PAP2_like_2 proteins. PAP2 is a super-family of phosphatases and haloperoxidases. This subgroup, which is specific to bacteria, lacks functional characterization and may act as a membrane-associated lipid phosphatase; Region: PAP2_like_2; cd03392
929506000914	Membrane-associated phospholipid phosphatase [Lipid metabolism]; Region: PgpB; COG0671
929506000915	active site
929506000916	Iron only hydrogenase large subunit, C-terminal domain [General function prediction only]; Region: COG4624
929506000917	4Fe-4S binding domain; Region: Fer4; pfam00037
929506000918	Iron only hydrogenase large subunit, C-terminal domain; Region: Fe_hyd_lg_C; pfam02906
929506000919	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3677
929506000920	InsA N-terminal domain; Region: Zn_Tnp_IS1; pfam03811
929506000921	DDE domain; Region: DDE_Tnp_IS240; pfam13610
929506000922	Integrase core domain; Region: rve; pfam00665
929506000923	Integrase core domain; Region: rve_3; pfam13683
929506000924	ABC-type Mn/Zn transport systems, ATPase component [Inorganic ion transport and metabolism]; Region: ZnuC; COG1121
929506000925	ATP-binding cassette domain of the metal-type transporters; Region: ABC_Metallic_Cations; cd03235
929506000926	ABC-type Mn2+/Zn2+ transport systems, permease components [Inorganic ion transport and metabolism]; Region: ZnuB; COG1108
929506000927	Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550
929506000928	ABC-ATPase subunit  interface; other site
929506000929	dimer interface [polypeptide binding]; other site
929506000930	putative PBP binding regions; other site
929506000931	UDP-N-acetylmuramate--L-alanine ligase; Provisional; Region: murC; PRK00421
929506000932	Mur ligase family, catalytic domain; Region: Mur_ligase; pfam01225
929506000933	Mur ligase middle domain; Region: Mur_ligase_M; pfam08245
929506000934	Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875
929506000935	pur operon repressor; Provisional; Region: PRK09213
929506000936	Bacterial purine repressor, N-terminal; Region: PuR_N; pfam09182
929506000937	Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223
929506000938	active site
929506000939	regulatory protein SpoVG; Reviewed; Region: PRK13259
929506000940	bifunctional N-acetylglucosamine-1-phosphate uridyltransferase/glucosamine-1-phosphate acetyltransferase; Provisional; Region: glmU; PRK14354
929506000941	N-terminal domain of bacterial GlmU; Region: GT2_GlmU_N_bac; cd02540
929506000942	Substrate binding site; other site
929506000943	Mg++ binding site; other site
929506000944	N-acetyl-glucosamine-1-phosphate uridyltransferase (GlmU), C-terminal left-handed beta-helix (LbH) acetyltransferase domain: GlmU is also known as UDP-N-acetylglucosamine pyrophosphorylase. It is a bifunctional bacterial enzyme that catalyzes two...; Region: LbH_GlmU_C; cd03353
929506000945	active site
929506000946	substrate binding site [chemical binding]; other site
929506000947	CoA binding site [chemical binding]; other site
929506000948	ribose-phosphate pyrophosphokinase; Provisional; Region: PRK01259
929506000949	N-terminal domain of ribose phosphate pyrophosphokinase; Region: Pribosyltran_N; pfam13793
929506000950	Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223
929506000951	active site
929506000952	Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745
929506000953	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
929506000954	active site
929506000955	phosphorylation site [posttranslational modification]
929506000956	intermolecular recognition site; other site
929506000957	dimerization interface [polypeptide binding]; other site
929506000958	Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383
929506000959	DNA binding site [nucleotide binding]
929506000960	Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642
929506000961	Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225
929506000962	dimerization interface [polypeptide binding]; other site
929506000963	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
929506000964	dimer interface [polypeptide binding]; other site
929506000965	phosphorylation site [posttranslational modification]
929506000966	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
929506000967	ATP binding site [chemical binding]; other site
929506000968	Mg2+ binding site [ion binding]; other site
929506000969	G-X-G motif; other site
929506000970	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain [Posttranslational modification, protein turnover, chaperones]; Region: DegQ; COG0265
929506000971	Trypsin-like peptidase domain; Region: Trypsin_2; pfam13365
929506000972	PDZ domain of tryspin-like serine proteases, such as DegP/HtrA, which are oligomeric proteins involved in heat-shock response, chaperone function, and apoptosis. May be responsible for substrate recognition and/or binding, as most PDZ domains bind...; Region: PDZ_serine_protease; cd00987
929506000973	protein binding site [polypeptide binding]; other site
929506000974	Peptidyl-tRNA hydrolase (PTH) is a monomeric protein that cleaves the ester bond linking the nascent peptide and tRNA when peptidyl-tRNA is released prematurely from the ribosome. This ensures the recycling of peptidyl-tRNAs into tRNAs produced through...; Region: PTH; cd00462
929506000975	putative active site [active]
929506000976	catalytic residue [active]
929506000977	Transcription-repair coupling factor (superfamily II helicase) [DNA replication, recombination, and repair / Transcription]; Region: Mfd; COG1197
929506000978	CarD-like/TRCF domain; Region: CarD_TRCF; smart01058
929506000979	DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046
929506000980	ATP binding site [chemical binding]; other site
929506000981	putative Mg++ binding site [ion binding]; other site
929506000982	Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079
929506000983	nucleotide binding region [chemical binding]; other site
929506000984	ATP-binding site [chemical binding]; other site
929506000985	This domain is found in proteins necessary for strand-specific repair in DNA such as TRCF in Escherichia coli; Region: TRCF; smart00982
929506000986	peptidylprolyl isomerase; Provisional; Region: prsA; PRK00059
929506000987	SurA N-terminal domain; Region: SurA_N_3; cl07813
929506000988	PPIC-type PPIASE domain; Region: Rotamase_3; pfam13616
929506000989	stage V sporulation protein T; Region: spore_V_T; TIGR02851
929506000990	looped-hinge helix DNA binding domain, AbrB family; Region: lp_hng_hel_AbrB; TIGR01439
929506000991	GAF domain; Region: GAF; cl17456
929506000992	Membrane protein involved in the export of O-antigen and teichoic acid [General function prediction only]; Region: RfbX; COG2244
929506000993	Stage V sporulation protein B, also known as Stage III sporulation protein F, and related proteins; Region: MATE_SpoVB_like; cd13124
929506000994	Protein containing tetrapyrrole methyltransferase domain and MazG-like (predicted pyrophosphatase) domain [General function prediction only]; Region: COG3956
929506000995	N-terminal S-AdoMet dependent methylase domain of Bacillus subtilis YabN and related proteins; Region: YabN_N; cd11723
929506000996	putative SAM binding site [chemical binding]; other site
929506000997	putative homodimer interface [polypeptide binding]; other site
929506000998	Nucleoside Triphosphate Pyrophosphohydrolase (EC 3.6.1.8) N-terminal tandem-domain of MazG proteins from Escherichia coli and bacterial homologs; Region: NTP-PPase_MazG_Nterm; cd11528
929506000999	homodimer interface [polypeptide binding]; other site
929506001000	metal binding site [ion binding]; metal-binding site
929506001001	Nucleoside Triphosphate Pyrophosphohydrolase (EC 3.6.1.8) C-terminal tandem-domain of MazG proteins from Escherichia coli and bacterial homologs' Region: NTP-PPase_MazG_Cterm; cd11529
929506001002	homodimer interface [polypeptide binding]; other site
929506001003	active site
929506001004	putative chemical substrate binding site [chemical binding]; other site
929506001005	metal binding site [ion binding]; metal-binding site
929506001006	Integration host factor (IHF) and HU are small heterodimeric members of the DNABII protein family that bind and bend DNA, functioning as architectural factors in many cellular processes including transcription, site-specific recombination, and...; Region: HU_IHF; cd00591
929506001007	IHF - DNA interface [nucleotide binding]; other site
929506001008	IHF dimer interface [polypeptide binding]; other site
929506001009	S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site;  Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165
929506001010	RNA binding surface [nucleotide binding]; other site
929506001011	YabP family; Region: YabP; cl06766
929506001012	Septum formation initiator; Region: DivIC; pfam04977
929506001013	hypothetical protein; Provisional; Region: PRK05807
929506001014	S1_like: Ribosomal protein S1-like RNA-binding domain. Found in a wide variety of RNA-associated proteins. Originally identified in S1 ribosomal protein. This superfamily also contains the Cold Shock Domain (CSD), which is a homolog of the S1 domain; Region: S1_like; cl09927
929506001015	RNA binding site [nucleotide binding]; other site
929506001016	Serine phosphatase RsbU, regulator of sigma subunit [Signal transduction mechanisms / Transcription]; Region: RsbU; COG2208
929506001017	Stage II sporulation protein E (SpoIIE); Region: SpoIIE; pfam07228
929506001018	tRNA(Ile)-lysidine synthase MesJ [Cell cycle control, cell division, chromosome partitioning]; Region: MesJ; COG0037
929506001019	N-terminal domain of predicted ATPase of the PP-loop faimly implicated in cell cycle control [Cell division and chromosome partitioning]. This is a subfamily of Adenine nucleotide alpha hydrolases superfamily.Adeninosine nucleotide alpha hydrolases...; Region: PP-ATPase; cd01992
929506001020	Ligand Binding Site [chemical binding]; other site
929506001021	TilS substrate C-terminal domain; Region: TilS_C; smart00977
929506001022	Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223
929506001023	active site
929506001024	FtsH Extracellular; Region: FtsH_ext; pfam06480
929506001025	ATP-dependent metalloprotease FtsH; Region: FtsH_fam; TIGR01241
929506001026	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
929506001027	Walker A motif; other site
929506001028	ATP binding site [chemical binding]; other site
929506001029	Walker B motif; other site
929506001030	arginine finger; other site
929506001031	Peptidase family M41; Region: Peptidase_M41; pfam01434
929506001032	PaaI_thioesterase is a tetrameric acyl-CoA thioesterase with a hot dog fold and one of several proteins responsible for phenylacetic acid (PA) degradation in bacteria.  Although orthologs of PaaI exist in archaea and eukaryotes, their function has not...; Region: PaaI_thioesterase; cd03443
929506001033	subunit interaction site [polypeptide binding]; other site
929506001034	PHB binding site; other site
929506001035	CoenzymeA binding site [chemical binding]; other site
929506001036	formate--tetrahydrofolate ligase; Provisional; Region: PRK13505
929506001037	Formyltetrahydrofolate synthetase (FTHFS) catalyzes the ATP-dependent activation of formate ion via its addition to the N10 position of tetrahydrofolate. FTHFS is a highly expressed key enzyme in both the Wood-Ljungdahl pathway of autotrophic CO2...; Region: FTHFS; cd00477
929506001038	Potassium binding sites [ion binding]; other site
929506001039	Cesium cation binding sites [ion binding]; other site
929506001040	Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cd00012
929506001041	nucleotide binding site [chemical binding]; other site
929506001042	putative TIM-barrel protein, nifR3 family; Region: nifR3_yhdG; TIGR00737
929506001043	Dihydrouridine synthase-like (DUS-like) FMN-binding domain. Members of this family catalyze the reduction of the 5,6-double bond of a uridine residue on tRNA. Dihydrouridine modification of tRNA is widely observed in prokaryotes and eukaryotes, and also...; Region: DUS_like_FMN; cd02801
929506001044	FMN binding site [chemical binding]; other site
929506001045	active site
929506001046	catalytic residues [active]
929506001047	substrate binding site [chemical binding]; other site
929506001048	transcription elongation factor GreA; Reviewed; Region: greA; PRK00226
929506001049	Transcription elongation factor, N-terminal; Region: GreA_GreB_N; pfam03449
929506001050	Transcription elongation factor, GreA/GreB, C-term; Region: GreA_GreB; pfam01272
929506001051	lysyl-tRNA synthetase; Reviewed; Region: lysS; PRK00484
929506001052	LysRS_N: N-terminal, anticodon recognition domain of lysyl-tRNA synthetases (LysRS). These enzymes are homodimeric class 2b aminoacyl-tRNA synthetases (aaRSs). This domain is a beta-barrel domain (OB fold) involved in binding the tRNA anticodon stem-loop; Region: LysRS_N; cd04322
929506001053	dimer interface [polypeptide binding]; other site
929506001054	putative anticodon binding site; other site
929506001055	Lys_tRNA synthetase (LysRS) class II core domain. Class II LysRS is a dimer which attaches a lysine to the 3' OH group of ribose of the appropriate tRNA. Its assignment to class II aaRS is based upon its structure and the presence of three...; Region: LysRS_core; cd00775
929506001056	motif 1; other site
929506001057	active site
929506001058	motif 2; other site
929506001059	motif 3; other site
929506001060	glycyl-tRNA synthetase; Provisional; Region: PRK04173
929506001061	Class II tRNA amino-acyl synthetase-like catalytic core domain. Class II amino acyl-tRNA synthetases (aaRS) share a common fold and generally attach an amino acid to the 3' OH of ribose of the appropriate tRNA.   PheRS is an exception in that it...; Region: class_II_aaRS-like_core; cl00268
929506001062	motif 1; other site
929506001063	Glycyl-tRNA synthetase (GlyRS)-like class II core catalytic domain. GlyRS functions as a homodimer in eukaryotes, archaea and some bacteria and as a heterotetramer in the remainder of prokaryotes. It is responsible for the attachment of glycine to the 3...; Region: GlyRS-like_core; cd00774
929506001064	active site
929506001065	motif 2; other site
929506001066	motif 3; other site
929506001067	GlyRS Glycyl-anticodon binding domain. GlyRS belongs to class II aminoacyl-tRNA synthetases (aaRS). This alignment contains the anticodon binding domain, which is responsible for specificity in tRNA-binding, so that the activated amino acid is...; Region: GlyRS_anticodon; cd00858
929506001068	anticodon binding site; other site
929506001069	UDP-N-acetylmuramoyl-L-alanyl-D-glutamate synthetase; Provisional; Region: murD; PRK01710
929506001070	Medium chain reductase/dehydrogenase (MDR)/zinc-dependent alcohol dehydrogenase-like family; Region: MDR; cl16912
929506001071	Mur ligase middle domain; Region: Mur_ligase_M; pfam08245
929506001072	InsA N-terminal domain; Region: Zn_Tnp_IS1; pfam03811
929506001073	DDE domain; Region: DDE_Tnp_IS240; pfam13610
929506001074	Integrase core domain; Region: rve; pfam00665
929506001075	Integrase core domain; Region: rve_3; pfam13683
929506001076	Elongation factor G (EF-G) family; Region: EF-G_bact; cd04170
929506001077	elongation factor G; Reviewed; Region: PRK12740
929506001078	G1 box; other site
929506001079	putative GEF interaction site [polypeptide binding]; other site
929506001080	GTP/Mg2+ binding site [chemical binding]; other site
929506001081	Switch I region; other site
929506001082	G2 box; other site
929506001083	G3 box; other site
929506001084	Switch II region; other site
929506001085	G4 box; other site
929506001086	G5 box; other site
929506001087	EFG_mtEFG_II: this subfamily represents the domain II of elongation factor G (EF-G) in bacteria and, the C-terminus of mitochondrial Elongation factor G1 (mtEFG1) and G2 (mtEFG2)_like proteins found in eukaryotes. During the process of peptide synthesis...; Region: EFG_mtEFG_II; cd04088
929506001088	EFG_mtEFG1_IV: domains similar to domain IV of the bacterial translational elongation factor (EF) EF-G. Included in this group is a domain of mitochondrial Elongation factor G1 (mtEFG1) proteins homologous to domain IV of EF-G. Eukaryotic cells harbor 2...; Region: EFG_mtEFG1_IV; cd01434
929506001089	EFG_mtEFG_C: domains similar to the C-terminal domain of the bacterial translational elongation factor (EF) EF-G.  Included in this group is the C-terminus of mitochondrial Elongation factor G1 (mtEFG1) and G2 (mtEFG2) proteins. Eukaryotic cells harbor 2...; Region: EFG_mtEFG_C; cd03713
929506001090	Rubrerythrin [Energy production and conversion]; Region: COG1592
929506001091	Rubrerythrin, ferritin-like diiron-binding domain; Region: Rubrerythrin; cd01041
929506001092	binuclear metal center [ion binding]; other site
929506001093	Rubredoxin, Small Modular nonheme iron binding domain containing a [Fe(SCys)4] center, present in rubrerythrin and nigerythrin and detected either N- or C-terminal to such proteins as flavin reductase, NAD(P)H-nitrite reductase, and...; Region: rubredoxin_SM; cd00729
929506001094	iron binding site [ion binding]; other site
929506001095	ISCb1g3, transposase truncated
929506001096	cardiolipin synthase; Region: bac_cardiolipin; TIGR04265
929506001097	Catalytic domain, repeat 1, of bacterial cardiolipin synthase and similar proteins; Region: PLDc_CLS_1; cd09110
929506001098	putative active site [active]
929506001099	catalytic site [active]
929506001100	catalytic domain repeat 2 of bacterial cardiolipin synthase and similar proteins; Region: PLDc_CLS_2; cd09112
929506001101	putative active site [active]
929506001102	catalytic site [active]
929506001103	PTS_IIB: subunit IIB of enzyme II (EII) is the central energy-coupling domain of the phosphoenolpyruvate:carbohydrate phosphotransferase system (PTS). In the multienzyme PTS complex, EII is a carbohydrate-specific permease consisting of two cytoplasmic...; Region: PTS_IIB; cl10014
929506001104	NADP oxidoreductase coenzyme F420-dependent; Region: F420_oxidored; pfam03807
929506001105	Domain of unknown function (DUF2520); Region: DUF2520; pfam10728
929506001106	Ketopantoate hydroxymethyltransferase (KPHMT) is the first enzyme in the pantothenate biosynthesis pathway. Ketopantoate hydroxymethyltransferase (KPHMT) catalyzes the first committed step in the biosynthesis of pantothenate (vitamin B5), which is a...; Region: KPHMT-like; cd06557
929506001107	oligomerization interface [polypeptide binding]; other site
929506001108	active site
929506001109	metal binding site [ion binding]; metal-binding site
929506001110	Pantoate-beta-alanine ligase; Region: PanC; cd00560
929506001111	pantoate--beta-alanine ligase; Region: panC; TIGR00018
929506001112	active site
929506001113	ATP-binding site [chemical binding]; other site
929506001114	pantoate-binding site; other site
929506001115	HXXH motif; other site
929506001116	Aspartate decarboxylase; Region: Asp_decarbox; pfam02261
929506001117	tetramerization interface [polypeptide binding]; other site
929506001118	Ferritin-like superfamily of diiron-containing four-helix-bundle proteins; Region: Ferritin_like; cd00657
929506001119	Uncharacterized conserved protein [Function unknown]; Region: COG1633
929506001120	dinuclear metal binding motif [ion binding]; other site
929506001121	anaerobic ribonucleoside triphosphate reductase; Provisional; Region: PRK07111
929506001122	ATP cone domain; Region: ATP-cone; pfam03477
929506001123	Class III ribonucleotide reductase; Region: RNR_III; cd01675
929506001124	effector binding site; other site
929506001125	active site
929506001126	Zn binding site [ion binding]; other site
929506001127	glycine loop; other site
929506001128	anaerobic ribonucleotide reductase-activating protein; Provisional; Region: nrdG; cl15804
929506001129	4Fe-4S single cluster domain; Region: Fer4_12; pfam13353
929506001130	TPR repeat; Region: TPR_11; pfam13414
929506001131	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
929506001132	binding surface
929506001133	TPR motif; other site
929506001134	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
929506001135	TPR repeat; Region: TPR_11; pfam13414
929506001136	binding surface
929506001137	TPR motif; other site
929506001138	TPR repeat; Region: TPR_11; pfam13414
929506001139	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
929506001140	TPR repeat; Region: TPR_11; pfam13414
929506001141	binding surface
929506001142	TPR motif; other site
929506001143	dipeptidase PepV; Reviewed; Region: PRK07318
929506001144	M20 Peptidase Xaa-His dipeptidase (PepV) degrades hydrophobic dipeptides; Region: M20_PepV; cd03888
929506001145	active site
929506001146	metal binding site [ion binding]; metal-binding site
929506001147	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
929506001148	Major Facilitator Superfamily; Region: MFS_1; pfam07690
929506001149	putative substrate translocation pore; other site
929506001150	Predicted membrane protein [Function unknown]; Region: COG4684
929506001151	Protein of unknown function (DUF3816); Region: DUF3816; pfam12822
929506001152	nylC-like family; composed of proteins with similarity to Flavobacterium endo-type 6-aminohexanoate-oligomer hydrolase (EIII), the product of the nylon oligomer degradation gene, nylC. EIII is an amide hydrolase that catalyzes the degradation of...; Region: nylC_like; cd02252
929506001153	putative active site pocket [active]
929506001154	cleavage site
929506001155	Rubredoxin, Small Modular nonheme iron binding domain containing a [Fe(SCys)4] center, present in rubrerythrin and nigerythrin and detected either N- or C-terminal to such proteins as flavin reductase, NAD(P)H-nitrite reductase, and...; Region: rubredoxin_SM; cd00729
929506001156	Rubredoxin; Region: Rubredoxin; pfam00301
929506001157	iron binding site [ion binding]; other site
929506001158	Rubrerythrin [Energy production and conversion]; Region: COG1592
929506001159	rubrerythrin-like, diiron-binding domain; Region: Rubrerythrin_like; cd01046
929506001160	diiron binding motif [ion binding]; other site
929506001161	Firmicute transcriptional repressor of class III stress genes (CtsR); Region: CtsR; pfam05848
929506001162	Modulator of heat shock repressor CtsR, McsA [Signal transduction    mechanisms]; Region: COG3880
929506001163	ATP:guanido phosphotransferase; Provisional; Region: PRK01059
929506001164	Phosphagen (guanidino) kinases found in bacteria; Region: bacterial_phosphagen_kinase; cd07930
929506001165	ADP binding site [chemical binding]; other site
929506001166	phosphagen binding site; other site
929506001167	substrate specificity loop; other site
929506001168	ATP-binding subunits of Clp protease and DnaK/DnaJ chaperones [Posttranslational modification, protein turnover, chaperones]; Region: clpA; COG0542
929506001169	Clp amino terminal domain; Region: Clp_N; pfam02861
929506001170	Clp amino terminal domain; Region: Clp_N; pfam02861
929506001171	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
929506001172	Walker A motif; other site
929506001173	ATP binding site [chemical binding]; other site
929506001174	Walker B motif; other site
929506001175	arginine finger; other site
929506001176	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
929506001177	Walker A motif; other site
929506001178	ATP binding site [chemical binding]; other site
929506001179	Walker B motif; other site
929506001180	C-terminal, D2-small domain, of ClpB protein; Region: ClpB_D2-small; smart01086
929506001181	DNA repair protein RadA; Provisional; Region: PRK11823
929506001182	Sms (bacterial radA) DNA repair protein. This protein is not related to archael radA any more than is to other RecA-like NTPases. Sms has a role in recombination and recombinational repair and is responsible for the stabilization or processing of...; Region: Sms; cd01121
929506001183	Walker A motif/ATP binding site; other site
929506001184	ATP binding site [chemical binding]; other site
929506001185	Walker B motif; other site
929506001186	Subunit ChlI of Mg-chelatase; Region: ChlI; pfam13541
929506001187	DNA integrity scanning protein DisA; Provisional; Region: PRK13482
929506001188	DisA bacterial checkpoint controller nucleotide-binding; Region: DisA_N; pfam02457
929506001189	DisA bacterial checkpoint controller linker region; Region: DisA-linker; pfam10635
929506001190	Integral membrane protein (PIN domain superfamily) [General function prediction only]; Region: COG4956
929506001191	PIN domain of Thermus Thermophilus Hb8, uncharacterized Bacillus subtilis YacL, and other bacterial homologs; Region: PIN_YacL; cd09877
929506001192	putative active site [active]
929506001193	CDP-ME synthetase is involved in mevalonate-independent isoprenoid production; Region: CDP-ME_synthetase; cd02516
929506001194	substrate binding site; other site
929506001195	dimer interface; other site
929506001196	cysteinyl-tRNA synthetase; Validated; Region: cysS; PRK00260
929506001197	catalytic core domain of cysteinyl tRNA synthetase; Region: CysRS_core; cd00672
929506001198	active site
929506001199	HIGH motif; other site
929506001200	catalytic core domain of cysteinyl tRNA synthetase; Region: CysRS_core; cd00672
929506001201	KMSKS motif; other site
929506001202	Anticodon-binding domain of cysteinyl tRNA synthetases; Region: Anticodon_Ia_Cys; cd07963
929506001203	tRNA binding surface [nucleotide binding]; other site
929506001204	anticodon binding site; other site
929506001205	RIBOc. Ribonuclease III C terminal domain. This group consists of eukaryotic, bacterial and archeal ribonuclease III (RNAse III) proteins. RNAse III is a double stranded RNA-specific endonuclease. Prokaryotic RNAse III is important in...; Region: RIBOc; cd00593
929506001206	dimerization interface [polypeptide binding]; other site
929506001207	active site
929506001208	metal binding site [ion binding]; metal-binding site
929506001209	FAD-dependent thymidylate synthase; Reviewed; Region: thyX; PRK00847
929506001210	rRNA methylases [Translation, ribosomal structure and biogenesis]; Region: SpoU; COG0566
929506001211	RNA 2'-O ribose methyltransferase substrate binding; Region: SpoU_sub_bind; pfam08032
929506001212	SpoU rRNA Methylase family; Region: SpoU_methylase; pfam00588
929506001213	YacP-like NYN domain; Region: NYN_YacP; pfam05991
929506001214	RNA polymerase sigma-H factor; Region: spore_sigH; TIGR02859
929506001215	Sigma-70 region 2; Region: Sigma70_r2; pfam04542
929506001216	Sigma-70, region 4; Region: Sigma70_r4_2; pfam08281
929506001217	elongation factor Tu; Reviewed; Region: PRK00049
929506001218	Elongation Factor Tu (EF-Tu) GTP-binding proteins; Region: EF_Tu; cd01884
929506001219	G1 box; other site
929506001220	GEF interaction site [polypeptide binding]; other site
929506001221	GTP/Mg2+ binding site [chemical binding]; other site
929506001222	Switch I region; other site
929506001223	G2 box; other site
929506001224	G3 box; other site
929506001225	Switch II region; other site
929506001226	G4 box; other site
929506001227	G5 box; other site
929506001228	EFTU_II: Elongation factor Tu domain II. Elongation factors Tu (EF-Tu) are three-domain GTPases with an essential function in the elongation phase of mRNA translation. The GTPase center of EF-Tu is in the N-terminal domain (domain I), also known as the...; Region: EFTU_II; cd03697
929506001229	Domain III of elongation factor (EF) Tu. Ef-Tu consists of three structural domains, designated I, II and III. Domain III adopts a beta barrel structure. Domain III is involved in binding to both charged tRNA and binding to elongation factor Ts (EF-Ts); Region: EFTU_III; cd03707
929506001230	Antibiotic Binding Site [chemical binding]; other site
929506001231	50S ribosomal protein L33; Validated; Region: rpmG; PRK00504
929506001232	SecE/Sec61-gamma subunits of protein translocation complex; Region: SecE; pfam00584
929506001233	transcription antitermination protein NusG; Validated; Region: nusG; PRK05609
929506001234	Bacterial N-Utilization Substance G (NusG) N-terminal (NGN) domain, subgroup 1; Region: NGN_Bact_1; cd09891
929506001235	putative homodimer interface [polypeptide binding]; other site
929506001236	NusG contains an NGN domain at its N-terminus and KOW motif at its C-terminus; Region: KOW_NusG; cd06091
929506001237	heterodimer interface [polypeptide binding]; other site
929506001238	homodimer interface [polypeptide binding]; other site
929506001239	50S ribosomal protein L11; Validated; Region: rplK; PRK00140
929506001240	Ribosomal protein L11. Ribosomal protein L11, together with proteins L10 and L7/L12, and 23S rRNA, form the L7/L12 stalk on the surface of the large subunit of the ribosome. The homologous eukaryotic cytoplasmic protein is also called 60S ribosomal...; Region: Ribosomal_L11; cd00349
929506001241	23S rRNA interface [nucleotide binding]; other site
929506001242	L7/L12 interface [polypeptide binding]; other site
929506001243	putative thiostrepton binding site; other site
929506001244	L25 interface [polypeptide binding]; other site
929506001245	Ribosomal protein L1.  The L1 protein, located near the E-site of the ribosome, forms part of the L1 stalk along with 23S rRNA.  In bacteria and archaea, L1 functions both as a ribosomal protein that binds rRNA, and as a translation repressor that binds...; Region: Ribosomal_L1; cd00403
929506001246	mRNA/rRNA interface [nucleotide binding]; other site
929506001247	Ribosomal protein L10 family, L10 subfamily; composed of bacterial 50S ribosomal protein and eukaryotic mitochondrial 39S ribosomal protein, L10. L10 occupies the L7/L12 stalk of the ribosome. The N-terminal domain (NTD) of L10 interacts with L11 protein...; Region: Ribosomal_L10; cd05797
929506001248	23S rRNA interface [nucleotide binding]; other site
929506001249	Interface with L7/L12 ribosomal proteins [polypeptide binding]; other site
929506001250	Ribosomal protein L7/L12. Ribosomal protein L7/L12 refers to the large ribosomal subunit proteins L7 and L12, which are identical except that L7 is acetylated at the N terminus. It is a component of the L7/L12 stalk, which is located at the surface of...; Region: Ribosomal_L7_L12; cd00387
929506001251	core dimer interface [polypeptide binding]; other site
929506001252	peripheral dimer interface [polypeptide binding]; other site
929506001253	L10 interface [polypeptide binding]; other site
929506001254	L11 interface [polypeptide binding]; other site
929506001255	putative EF-Tu interaction site [polypeptide binding]; other site
929506001256	putative EF-G interaction site [polypeptide binding]; other site
929506001257	RNA polymerase beta subunit. RNA polymerases catalyse the DNA dependent polymerization of RNA. Prokaryotes contain a single RNA polymerase compared to three in eukaryotes (not including mitochondrial. and chloroplast polymerases). Each RNA polymerase...; Region: RNA_pol_B_RPB2; cl17585
929506001258	RNA polymerase Rpb2, domain 2; Region: RNA_pol_Rpb2_2; pfam04561
929506001259	RNA polymerase beta subunit. RNA polymerases catalyse the DNA dependent polymerization of RNA. Prokaryotes contain a single RNA polymerase compared to three in eukaryotes (not including mitochondrial. and chloroplast polymerases). Each RNA polymerase...; Region: RNA_pol_B_RPB2; cd00653
929506001260	DNA-directed RNA polymerase subunit beta; Reviewed; Region: rpoB; PRK00405
929506001261	RPB1 interaction site [polypeptide binding]; other site
929506001262	RPB10 interaction site [polypeptide binding]; other site
929506001263	RPB11 interaction site [polypeptide binding]; other site
929506001264	RPB3 interaction site [polypeptide binding]; other site
929506001265	RPB12 interaction site [polypeptide binding]; other site
929506001266	RNA polymerase Rpb1, domain 1; Region: RNA_pol_Rpb1_1; pfam04997
929506001267	DNA-directed RNA polymerase subunit beta'; Provisional; Region: PRK00566
929506001268	RNA polymerase I subunit A N-terminus; Region: RPOLA_N; smart00663
929506001269	RNA polymerase Rpb1, domain 3; Region: RNA_pol_Rpb1_3; pfam04983
929506001270	RNA polymerase Rpb1, domain 4; Region: RNA_pol_Rpb1_4; pfam05000
929506001271	Largest subunit (beta') of Bacterial DNA-dependent RNA polymerase (RNAP), C-terminal domain; Region: RNAP_beta'_C; cd02655
929506001272	Rpb1 (beta') - Rpb6 (omega) interaction site [polypeptide binding]; other site
929506001273	G-loop; other site
929506001274	Largest subunit (beta') of Bacterial DNA-dependent RNA polymerase (RNAP), C-terminal domain; Region: RNAP_beta'_C; cd02655
929506001275	DNA binding site [nucleotide binding]
929506001276	Rpb1 (beta') - Rpb2 (beta) interaction site [polypeptide binding]; other site
929506001277	Ribosomal protein L7Ae/L30e/S12e/Gadd45 family; Region: Ribosomal_L7Ae; cl00600
929506001278	S12-like family, 30S ribosomal protein S12 subfamily; S12 is located at the interface of the large and small ribosomal subunits of prokaryotes, chloroplasts and mitochondria, where it plays an important role in both tRNA and ribosomal subunit...; Region: Ribosomal_S12; cd03368
929506001279	S17 interaction site [polypeptide binding]; other site
929506001280	S8 interaction site; other site
929506001281	16S rRNA interaction site [nucleotide binding]; other site
929506001282	streptomycin interaction site [chemical binding]; other site
929506001283	23S rRNA interaction site [nucleotide binding]; other site
929506001284	aminoacyl-tRNA interaction site (A-site) [nucleotide binding]; other site
929506001285	30S ribosomal protein S7; Validated; Region: PRK05302
929506001286	elongation factor G; Reviewed; Region: PRK00007
929506001287	Elongation factor G (EF-G) family involved in both the elongation and ribosome recycling phases of protein synthesis; Region: EF-G; cd01886
929506001288	G1 box; other site
929506001289	putative GEF interaction site [polypeptide binding]; other site
929506001290	GTP/Mg2+ binding site [chemical binding]; other site
929506001291	Switch I region; other site
929506001292	G2 box; other site
929506001293	G3 box; other site
929506001294	Switch II region; other site
929506001295	G4 box; other site
929506001296	G5 box; other site
929506001297	EFG_mtEFG_II: this subfamily represents the domain II of elongation factor G (EF-G) in bacteria and, the C-terminus of mitochondrial Elongation factor G1 (mtEFG1) and G2 (mtEFG2)_like proteins found in eukaryotes. During the process of peptide synthesis...; Region: EFG_mtEFG_II; cd04088
929506001298	EFG_mtEFG1_IV: domains similar to domain IV of the bacterial translational elongation factor (EF) EF-G. Included in this group is a domain of mitochondrial Elongation factor G1 (mtEFG1) proteins homologous to domain IV of EF-G. Eukaryotic cells harbor 2...; Region: EFG_mtEFG1_IV; cd01434
929506001299	EFG_mtEFG_C: domains similar to the C-terminal domain of the bacterial translational elongation factor (EF) EF-G.  Included in this group is the C-terminus of mitochondrial Elongation factor G1 (mtEFG1) and G2 (mtEFG2) proteins. Eukaryotic cells harbor 2...; Region: EFG_mtEFG_C; cd03713
929506001300	elongation factor Tu; Reviewed; Region: PRK00049
929506001301	Elongation Factor Tu (EF-Tu) GTP-binding proteins; Region: EF_Tu; cd01884
929506001302	G1 box; other site
929506001303	GEF interaction site [polypeptide binding]; other site
929506001304	GTP/Mg2+ binding site [chemical binding]; other site
929506001305	Switch I region; other site
929506001306	G2 box; other site
929506001307	G3 box; other site
929506001308	Switch II region; other site
929506001309	G4 box; other site
929506001310	G5 box; other site
929506001311	EFTU_II: Elongation factor Tu domain II. Elongation factors Tu (EF-Tu) are three-domain GTPases with an essential function in the elongation phase of mRNA translation. The GTPase center of EF-Tu is in the N-terminal domain (domain I), also known as the...; Region: EFTU_II; cd03697
929506001312	Domain III of elongation factor (EF) Tu. Ef-Tu consists of three structural domains, designated I, II and III. Domain III adopts a beta barrel structure. Domain III is involved in binding to both charged tRNA and binding to elongation factor Ts (EF-Ts); Region: EFTU_III; cd03707
929506001313	Antibiotic Binding Site [chemical binding]; other site
929506001314	30S ribosomal protein S10; Reviewed; Region: rpsJ; PRK00596
929506001315	50S ribosomal protein L3; Validated; Region: rplC; PRK00001
929506001316	50S ribosomal protein L4; Provisional; Region: rplD; PRK05319
929506001317	50S ribosomal protein L23; Reviewed; Region: rplW; PRK05738
929506001318	50S ribosomal protein L2; Validated; Region: rplB; PRK09374
929506001319	Ribosomal Proteins L2, RNA binding domain; Region: Ribosomal_L2; pfam00181
929506001320	Ribosomal Proteins L2, C-terminal domain; Region: Ribosomal_L2_C; pfam03947
929506001321	30S ribosomal protein S19; Reviewed; Region: rpsS; PRK00357
929506001322	Ribosomal protein L22/L17e.  L22 (L17 in eukaryotes) is a core protein of the large ribosomal subunit.  It is the only ribosomal protein that interacts with all six domains of 23S rRNA, and is one of the proteins important for directing the proper...; Region: Ribosomal_L22; cd00336
929506001323	putative translocon binding site; other site
929506001324	protein-rRNA interface [nucleotide binding]; other site
929506001325	30S ribosomal protein S3; Reviewed; Region: rpsC; PRK00310
929506001326	K homology RNA-binding (KH) domain of the prokaryotic 30S small ribosomal subunit protein S3. S3  is part of the head region of the 30S ribosomal subunit and is believed to interact with mRNA as it threads its way from the latch into the channel.  The KH...; Region: 30S_S3_KH; cd02412
929506001327	G-X-X-G motif; other site
929506001328	Ribosomal protein S3, C-terminal domain; Region: Ribosomal_S3_C; pfam00189
929506001329	Ribosomal_L16_L10e: L16 is an essential protein in the large ribosomal subunit of bacteria, mitochondria, and chloroplasts. Large subunits that lack L16 are defective in peptidyl transferase activity, peptidyl-tRNA hydrolysis activity, association with...; Region: Ribosomal_L16_L10e; cd01433
929506001330	23S rRNA interface [nucleotide binding]; other site
929506001331	5S rRNA interface [nucleotide binding]; other site
929506001332	putative antibiotic binding site [chemical binding]; other site
929506001333	L25 interface [polypeptide binding]; other site
929506001334	L27 interface [polypeptide binding]; other site
929506001335	Ribosomal L29 protein/HIP.  L29 is a protein of the large ribosomal Subunit. A homolog, called heparin/heparan sulfate interacting protein (HIP), has also been identified in mammals.  L29 is located on the surface of the large ribosomal subunit, where it...; Region: Ribosomal_L29_HIP; cd00427
929506001336	23S rRNA interface [nucleotide binding]; other site
929506001337	putative translocon interaction site; other site
929506001338	signal recognition particle (SRP54) interaction site; other site
929506001339	L23 interface [polypeptide binding]; other site
929506001340	trigger factor interaction site; other site
929506001341	30S ribosomal protein S17; Reviewed; Region: rpsQ; PRK05610
929506001342	50S ribosomal protein L14; Validated; Region: rplN; PRK05483
929506001343	50S ribosomal protein L24; Reviewed; Region: rplX; PRK00004
929506001344	KOW motif of Ribosomal Protein L26; Region: KOW_RPL26; cd06089
929506001345	RNA binding site [nucleotide binding]; other site
929506001346	50S ribosomal protein L5; Validated; Region: rplE; PRK00010
929506001347	Ribosomal protein L5; Region: Ribosomal_L5; pfam00281
929506001348	ribosomal L5P family C-terminus; Region: Ribosomal_L5_C; pfam00673
929506001349	30S ribosomal protein S14; Reviewed; Region: rpsN; PRK08061
929506001350	30S ribosomal protein S8; Validated; Region: rpsH; PRK00136
929506001351	50S ribosomal protein L6; Validated; Region: rplF; PRK05498
929506001352	Ribosomal protein L6; Region: Ribosomal_L6; pfam00347
929506001353	Ribosomal protein L6; Region: Ribosomal_L6; pfam00347
929506001354	Ribosomal L18/L5e:  L18 (L5e) is a ribosomal protein found in the central protuberance (CP) of the large subunit. L18 binds 5S rRNA and induces a conformational change that stimulates the binding of L5 to 5S rRNA. Association of 5S rRNA with 23S rRNA...; Region: Ribosomal_L18_L5e; cd00432
929506001355	5S rRNA interface [nucleotide binding]; other site
929506001356	L27 interface [polypeptide binding]; other site
929506001357	23S rRNA interface [nucleotide binding]; other site
929506001358	L5 interface [polypeptide binding]; other site
929506001359	30S ribosomal protein S5; Validated; Region: rpsE; PRK00550
929506001360	Ribosomal protein S5, N-terminal domain; Region: Ribosomal_S5; pfam00333
929506001361	Ribosomal protein S5, C-terminal domain; Region: Ribosomal_S5_C; pfam03719
929506001362	Ribosomal protein L30, which is found in eukaryotes and prokaryotes but not in archaea, is one of the smallest ribosomal proteins with a molecular mass of about 7kDa. L30 binds the 23SrRNA as well as the 5S rRNA and is one of five ribosomal proteins that...; Region: Ribosomal_L30; cd01658
929506001363	23S rRNA binding site [nucleotide binding]; other site
929506001364	50S ribosomal protein L15; Reviewed; Region: rplO; PRK05592
929506001365	preprotein translocase subunit SecY; Reviewed; Region: secY; PRK09204
929506001366	SecY translocase; Region: SecY; pfam00344
929506001367	adenylate kinase; Reviewed; Region: adk; PRK00279
929506001368	Adenylate kinase (ADK) catalyzes the reversible phosphoryl transfer from adenosine triphosphates (ATP) to adenosine monophosphates (AMP) and to yield adenosine diphosphates (ADP). This enzyme is required for the biosynthesis of ADP and is essential for...; Region: ADK; cd01428
929506001369	AMP-binding site [chemical binding]; other site
929506001370	ATP-AMP (Ap5A)-binding site [chemical binding]; other site
929506001371	Methionine Aminopeptidase 1. E.C. 3.4.11.18. Also known as methionyl aminopeptidase and Peptidase M. Catalyzes release of N-terminal amino acids, preferentially methionine, from peptides and arylamides; Region: MetAP1; cd01086
929506001372	active site
929506001373	KOW motif of Ribosomal Protein L14; Region: KOW_RPL14; cd06088
929506001374	RNA binding site [nucleotide binding]; other site
929506001375	S1_IF1: Translation Initiation Factor IF1, S1-like RNA-binding domain. IF1 contains an S1-like RNA-binding domain, which is found in a wide variety of RNA-associated proteins. Translation initiation includes a number of interrelated steps preceding the...; Region: S1_IF1; cd04451
929506001376	rRNA binding site [nucleotide binding]; other site
929506001377	predicted 30S ribosome binding site; other site
929506001378	50S ribosomal protein L36; Reviewed; Region: rpmJ; PRK00465
929506001379	30S ribosomal protein S13; Validated; Region: rpsM; PRK05179
929506001380	30S ribosomal protein S13; Region: bact_S13; TIGR03631
929506001381	30S ribosomal protein S11; Validated; Region: PRK05309
929506001382	30S ribosomal protein S4; Validated; Region: rpsD; PRK05327
929506001383	Ribosomal protein S4/S9 N-terminal domain; Region: Ribosomal_S4; pfam00163
929506001384	S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site;  Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165
929506001385	RNA binding surface [nucleotide binding]; other site
929506001386	DNA-directed RNA polymerase subunit alpha; Provisional; Region: PRK05182
929506001387	N-terminal domain of the Alpha subunit of Bacterial RNA polymerase; Region: RNAP_alpha_NTD; cd06928
929506001388	alphaNTD - beta interaction site [polypeptide binding]; other site
929506001389	alphaNTD homodimer interface [polypeptide binding]; other site
929506001390	alphaNTD - beta' interaction site [polypeptide binding]; other site
929506001391	Bacterial RNA polymerase, alpha chain C terminal domain; Region: RNA_pol_A_CTD; pfam03118
929506001392	50S ribosomal protein L17; Validated; Region: rplQ; PRK05591
929506001393	cobalt transporter ATP-binding subunit; Provisional; Region: PRK13633
929506001394	First domain of the ATP-binding cassette component of cobalt transport system; Region: ABC_cobalt_CbiO_domain1; cd03225
929506001395	Walker A/P-loop; other site
929506001396	ATP binding site [chemical binding]; other site
929506001397	Q-loop/lid; other site
929506001398	ABC transporter signature motif; other site
929506001399	Walker B; other site
929506001400	D-loop; other site
929506001401	H-loop/switch region; other site
929506001402	cobalt transporter ATP-binding subunit; Provisional; Region: cbiO; PRK13637
929506001403	First domain of the ATP-binding cassette component of cobalt transport system; Region: ABC_cobalt_CbiO_domain1; cd03225
929506001404	Walker A/P-loop; other site
929506001405	ATP binding site [chemical binding]; other site
929506001406	Q-loop/lid; other site
929506001407	ABC transporter signature motif; other site
929506001408	Walker B; other site
929506001409	D-loop; other site
929506001410	H-loop/switch region; other site
929506001411	ABC-type cobalt transport system, permease component CbiQ and related transporters [Inorganic ion transport and metabolism]; Region: CbiQ; COG0619
929506001412	tRNA pseudouridine synthase A; Validated; Region: truA; PRK00021
929506001413	Eukaryotic and bacterial pseudouridine synthases similar to E.  coli TruA; Region: PseudoU_synth_EcTruA; cd02570
929506001414	dimerization interface 3.5A [polypeptide binding]; other site
929506001415	active site
929506001416	Ribosomal protein L13.  Protein L13, a large ribosomal subunit protein, is one of five proteins required for an early folding intermediate of 23S rRNA in the assembly of the large subunit. L13 is situated on the bottom of the large subunit, near the...; Region: Ribosomal_L13; cd00392
929506001417	23S rRNA interface [nucleotide binding]; other site
929506001418	L3 interface [polypeptide binding]; other site
929506001419	30S ribosomal protein S9; Reviewed; Region: rpsI; PRK00132
929506001420	N-acetylmuramoyl-L-alanine amidase [Cell envelope biogenesis, outer membrane]; Region: AmiC; COG0860
929506001421	N-acetylmuramoyl-L-alanine amidase or MurNAc-LAA (also known as peptidoglycan aminohydrolase, NAMLA amidase, NAMLAA, Amidase 3, and peptidoglycan amidase; EC 3.5.1.28) is an autolysin that hydrolyzes the amide bond between N-acetylmuramoyl and L-amino...; Region: MurNAc-LAA; cd02696
929506001422	active site
929506001423	metal binding site [ion binding]; metal-binding site
929506001424	Apo-citrate lyase phosphoribosyl-dephospho-CoA transferase; Region: CitX; cl01498
929506001425	Na+/phosphate symporter [Inorganic ion transport and metabolism]; Region: NptA; COG1283
929506001426	Na+/Pi-cotransporter; Region: Na_Pi_cotrans; pfam02690
929506001427	Na+/Pi-cotransporter; Region: Na_Pi_cotrans; pfam02690
929506001428	PhoU domain; Region: PhoU; pfam01895
929506001429	PhoU domain; Region: PhoU; pfam01895
929506001430	Phosphoenolpyruvate-protein kinase (PTS system EI component in bacteria) [Carbohydrate transport and metabolism]; Region: PtsA; COG1080
929506001431	PEP-utilising enzyme, N-terminal; Region: PEP-utilisers_N; pfam05524
929506001432	PEP-utilising enzyme, mobile domain; Region: PEP-utilizers; pfam00391
929506001433	PEP-utilising enzyme, TIM barrel domain; Region: PEP-utilizers_C; pfam02896
929506001434	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
929506001435	binding surface
929506001436	TPR motif; other site
929506001437	Tetratricopeptide repeat; Region: TPR_12; pfam13424
929506001438	TRX family; composed of two groups: Group I, which includes proteins that exclusively encode a TRX domain; and Group II, which are composed of fusion proteins of TRX and additional domains. Group I TRX is a small ancient protein that alter the redox...; Region: TRX_family; cd02947
929506001439	Thioredoxin-like; Region: Thioredoxin_8; pfam13905
929506001440	catalytic residues [active]
929506001441	thioredoxin-disulfide reductase; Region: TRX_reduct; TIGR01292
929506001442	Cell Wall Hydrolase; Region: Hydrolase_2; pfam07486
929506001443	Uncharacterized conserved protein [Function unknown]; Region: COG1624
929506001444	DisA bacterial checkpoint controller nucleotide-binding; Region: DisA_N; pfam02457
929506001445	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4856
929506001446	YbbR-like protein; Region: YbbR; pfam07949
929506001447	Uncharacterized FAD-dependent dehydrogenases [General function prediction only]; Region: COG2509
929506001448	NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500
929506001449	phosphoglucosamine mutase; Provisional; Region: glmM; PRK14316
929506001450	GlmM is a bacterial phosphoglucosamine mutase (PNGM) that belongs to the alpha-D-phosphohexomutase superfamily. It is required for the interconversion of glucosamine-6-phosphate and glucosamine-1-phosphate in the biosynthetic pathway of...; Region: GlmM; cd05802
929506001451	active site
929506001452	substrate binding site [chemical binding]; other site
929506001453	metal binding site [ion binding]; metal-binding site
929506001454	glucosamine--fructose-6-phosphate aminotransferase; Reviewed; Region: PRK00331
929506001455	Glutamine amidotransferases class-II (Gn-AT)_GFAT-type. This domain is found at the N-terminus of glucosamine-6P synthase (GlmS, or GFAT in humans).  The glutaminase domain catalyzes amide nitrogen transfer from glutamine to the appropriate substrate. In...; Region: GFAT; cd00714
929506001456	glutaminase active site [active]
929506001457	SIS (Sugar ISomerase) domain repeat 1 found in Glucosamine 6-phosphate synthase (GlmS) and Glucosamine-6-phosphate deaminase (GlmD). The SIS domain is found in many phosphosugar isomerases and phosphosugar binding proteins. GlmS contains a N-terminal...; Region: SIS_GlmS_GlmD_1; cd05008
929506001458	dimer interface [polypeptide binding]; other site
929506001459	active site
929506001460	SIS (Sugar ISomerase) domain repeat 2 found in Glucosamine 6-phosphate synthase (GlmS) and Glucosamine-6-phosphate deaminase (GlmD). The SIS domain is found in many phosphosugar isomerases and phosphosugar binding proteins. GlmS contains a N-terminal...; Region: SIS_GlmS_GlmD_2; cd05009
929506001461	dimer interface [polypeptide binding]; other site
929506001462	active site
929506001463	Predicted transcriptional regulators [Transcription]; Region: COG1695
929506001464	Transcriptional regulator PadR-like family; Region: PadR; pfam03551
929506001465	Rubredoxin [Energy production and conversion]; Region: COG1773
929506001466	Rubredoxin; nonheme iron binding domains containing a [Fe(SCys)4] center. Rubredoxins are small nonheme iron proteins. The iron atom is coordinated by four cysteine residues (Fe(S-Cys)4), but iron can also be replaced by cobalt, nickel or zinc. They are...; Region: rubredoxin; cd00730
929506001467	iron binding site [ion binding]; other site
929506001468	phosphate regulon transcriptional regulatory protein PhoB; Region: PhoB; TIGR02154
929506001469	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
929506001470	active site
929506001471	phosphorylation site [posttranslational modification]
929506001472	intermolecular recognition site; other site
929506001473	dimerization interface [polypeptide binding]; other site
929506001474	Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383
929506001475	DNA binding site [nucleotide binding]
929506001476	Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225
929506001477	dimerization interface [polypeptide binding]; other site
929506001478	Signal transduction histidine kinase [Signal transduction mechanisms]; Region: COG3920
929506001479	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
929506001480	dimer interface [polypeptide binding]; other site
929506001481	phosphorylation site [posttranslational modification]
929506001482	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
929506001483	ATP binding site [chemical binding]; other site
929506001484	Mg2+ binding site [ion binding]; other site
929506001485	G-X-G motif; other site
929506001486	translocation protein TolB; Provisional; Region: tolB; PRK01029
929506001487	Membrane-associated phospholipid phosphatase [Lipid metabolism]; Region: PgpB; COG0671
929506001488	PAP2_like_3 proteins. PAP2 is a super-family of phosphatases and haloperoxidases. This subgroup, which is specific to bacteria and archaea, lacks functional characterization and may act as a membrane-associated lipid phosphatase; Region: PAP2_like_3; cd03393
929506001489	active site
929506001490	Sulfate transporter N-terminal domain with GLY motif; Region: Sulfate_tra_GLY; pfam13792
929506001491	putative transporter; Provisional; Region: PRK11660
929506001492	Sulfate transporter family; Region: Sulfate_transp; pfam00916
929506001493	Sulphate Transporter and Anti-Sigma factor antagonist domain of SulP-like sulfate transporters, plays a role in the function and regulation of the transport activity, proposed general NTP binding function; Region: STAS_SulP_like_sulfate_transporter; cd07042
929506001494	magnesium-transporting ATPase MgtA; Provisional; Region: PRK10517
929506001495	Cation transporter/ATPase, N-terminus; Region: Cation_ATPase_N; pfam00690
929506001496	E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122
929506001497	Putative hydrolase of sodium-potassium ATPase alpha subunit; Region: Hydrolase_like2; pfam13246
929506001498	haloacid dehalogenase-like hydrolase; Region: HAD; pfam12710
929506001499	Cation transporting ATPase, C-terminus; Region: Cation_ATPase_C; pfam00689
929506001500	MerR HTH family regulatory protein; Region: MerR_1; pfam13411
929506001501	helix_turn_helix, mercury resistance; Region: HTH_MERR; smart00422
929506001502	DNA binding residues [nucleotide binding]
929506001503	Penicillinase repressor; Region: Pencillinase_R; cl17580
929506001504	BlaR1 peptidase M56; Region: Peptidase_M56; pfam05569
929506001505	RNA polymerase sigma factor, sigma-70 family; Region: sigma70-ECF; TIGR02937
929506001506	Sigma-70 region 2; Region: Sigma70_r2; pfam04542
929506001507	Sigma-70, region 4; Region: Sigma70_r4_2; pfam08281
929506001508	DNA binding residues [nucleotide binding]
929506001509	ABC-type multidrug transport system, ATPase component [Defense mechanisms]; Region: CcmA; COG1131
929506001510	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
929506001511	Walker A/P-loop; other site
929506001512	ATP binding site [chemical binding]; other site
929506001513	Q-loop/lid; other site
929506001514	ABC transporter signature motif; other site
929506001515	Walker B; other site
929506001516	D-loop; other site
929506001517	H-loop/switch region; other site
929506001518	Ferric uptake regulator(Fur) and related metalloregulatory proteins; typically iron-dependent, DNA-binding repressors and activators; Region: Fur_like; cl17326
929506001519	metal binding site 2 [ion binding]; metal-binding site
929506001520	metal binding site 1 [ion binding]; metal-binding site
929506001521	structural Zn2+ binding site [ion binding]; other site
929506001522	Membrane transport protein; Region: Mem_trans; cl09117
929506001523	Transposase domain (DUF772); Region: DUF772; pfam05598
929506001524	Transposase DDE domain; Region: DDE_Tnp_1_6; pfam13751
929506001525	ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136
929506001526	ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255
929506001527	Walker A/P-loop; other site
929506001528	ATP binding site [chemical binding]; other site
929506001529	Q-loop/lid; other site
929506001530	ABC transporter signature motif; other site
929506001531	Walker B; other site
929506001532	D-loop; other site
929506001533	H-loop/switch region; other site
929506001534	ABC-type transport system, involved in lipoprotein release, permease component [Cell envelope biogenesis, outer membrane]; Region: LolE; COG4591
929506001535	MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704
929506001536	FtsX-like permease family; Region: FtsX; pfam02687
929506001537	MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704
929506001538	FtsX-like permease family; Region: FtsX; pfam02687
929506001539	Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745
929506001540	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
929506001541	active site
929506001542	phosphorylation site [posttranslational modification]
929506001543	intermolecular recognition site; other site
929506001544	dimerization interface [polypeptide binding]; other site
929506001545	Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383
929506001546	DNA binding site [nucleotide binding]
929506001547	Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642
929506001548	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
929506001549	phosphorylation site [posttranslational modification]
929506001550	dimer interface [polypeptide binding]; other site
929506001551	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
929506001552	ATP binding site [chemical binding]; other site
929506001553	Mg2+ binding site [ion binding]; other site
929506001554	G-X-G motif; other site
929506001555	ABC-type branched-chain amino acid transport systems, ATPase component [Amino acid transport and metabolism]; Region: LivF; COG0410
929506001556	ATP-binding cassette domain of the drug resistance transporter and related proteins, subfamily A; Region: ABC_DR_subfamily_A; cd03230
929506001557	Walker A/P-loop; other site
929506001558	ATP binding site [chemical binding]; other site
929506001559	Q-loop/lid; other site
929506001560	ABC transporter signature motif; other site
929506001561	Walker B; other site
929506001562	D-loop; other site
929506001563	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301
929506001564	Coenzyme A binding pocket [chemical binding]; other site
929506001565	Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093
929506001566	non-specific DNA binding site [nucleotide binding]; other site
929506001567	salt bridge; other site
929506001568	sequence-specific DNA binding site [nucleotide binding]; other site
929506001569	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3677
929506001570	InsA N-terminal domain; Region: Zn_Tnp_IS1; pfam03811
929506001571	DDE domain; Region: DDE_Tnp_IS240; pfam13610
929506001572	Integrase core domain; Region: rve; pfam00665
929506001573	Integrase core domain; Region: rve_3; pfam13683
929506001574	Predicted membrane protein [Function unknown]; Region: COG1971
929506001575	Domain of unknown function DUF; Region: DUF204; pfam02659
929506001576	Four helix bundle sensory module for signal transduction; Region: 4HB_MCP_1; pfam12729
929506001577	HAMP (Histidine kinases, Adenylyl cyclases, Methyl binding proteins, Phosphatases) domain; Region: HAMP; smart00304
929506001578	dimerization interface [polypeptide binding]; other site
929506001579	Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer); Region: MA; smart00283
929506001580	Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386
929506001581	dimer interface [polypeptide binding]; other site
929506001582	putative CheW interface [polypeptide binding]; other site
929506001583	Four helix bundle sensory module for signal transduction; Region: 4HB_MCP_1; pfam12729
929506001584	Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225
929506001585	dimerization interface [polypeptide binding]; other site
929506001586	Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386
929506001587	Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer); Region: MA; smart00283
929506001588	Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386
929506001589	dimer interface [polypeptide binding]; other site
929506001590	putative CheW interface [polypeptide binding]; other site
929506001591	Uncharacterized protein conserved in bacteria (DUF2325); Region: DUF2325; cl01811
929506001592	Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090
929506001593	dimerization interface [polypeptide binding]; other site
929506001594	putative DNA binding site [nucleotide binding]; other site
929506001595	putative Zn2+ binding site [ion binding]; other site
929506001596	Heavy-metal-associated domain (HMA) is a conserved domain of approximately 30 amino acid residues found in a number of proteins that transport or detoxify heavy metals, for example, the CPx-type heavy metal ATPases and copper chaperones. HMA domain...; Region: HMA; cd00371
929506001597	Cation transport ATPase [Inorganic ion transport and metabolism]; Region: ZntA; COG2217
929506001598	metal-binding site [ion binding]
929506001599	E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122
929506001600	Soluble P-type ATPase [General function prediction only]; Region: COG4087
929506001601	Metal-dependent amidase/aminoacylase/carboxypeptidase [General function prediction only]; Region: AbgB; COG1473
929506001602	M20 Peptidase Aminoacylase 1-like protein 2, amidohydrolase family; Region: M20_Acy1L2_like_2; cd09849
929506001603	metal binding site [ion binding]; metal-binding site
929506001604	Protein of unknown function (DUF3100); Region: DUF3100; pfam11299
929506001605	PAS domain; Region: PAS; smart00091
929506001606	FOG: PAS/PAC domain [Signal transduction mechanisms]; Region: AtoS; COG2202
929506001607	phosphate regulon sensor kinase PhoR; Region: phoR_proteo; TIGR02966
929506001608	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
929506001609	putative active site [active]
929506001610	heme pocket [chemical binding]; other site
929506001611	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
929506001612	dimer interface [polypeptide binding]; other site
929506001613	phosphorylation site [posttranslational modification]
929506001614	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
929506001615	ATP binding site [chemical binding]; other site
929506001616	Mg2+ binding site [ion binding]; other site
929506001617	G-X-G motif; other site
929506001618	SNARE associated Golgi protein; Region: SNARE_assoc; cl00429
929506001619	Uncharacterized membrane-associated protein [Function unknown]; Region: DedA; COG0586
929506001620	Dihydrofolate reductase [Coenzyme metabolism]; Region: FolA; COG0262
929506001621	Dihydrofolate reductase (DHFR). Reduces 7,8-dihydrofolate to 5,6,7,8-tetrahydrofolate with NADPH as a cofactor. This is an essential step in the biosynthesis of deoxythymidine phosphate since 5,6,7,8-tetrahydrofolate is required to regenerate 5; Region: DHFR; cd00209
929506001622	folate binding site [chemical binding]; other site
929506001623	NADP+ binding site [chemical binding]; other site
929506001624	Protein of unknown function (DUF441); Region: DUF441; pfam04284
929506001625	Bacterial cell division membrane protein [Cell division and chromosome partitioning]; Region: FtsW; COG0772
929506001626	Predicted transcriptional regulators [Transcription]; Region: COG1695
929506001627	Transcriptional regulator PadR-like family; Region: PadR; pfam03551
929506001628	O-acetylhomoserine sulfhydrylase [Amino acid transport and metabolism]; Region: MET17; COG2873
929506001629	CGS_like: Cystathionine gamma-synthase is a PLP dependent enzyme and catalyzes the committed step of methionine biosynthesis. This pathway is unique to microorganisms and plants, rendering the enzyme an attractive target for the development of...; Region: CGS_like; cd00614
929506001630	homodimer interface [polypeptide binding]; other site
929506001631	substrate-cofactor binding pocket; other site
929506001632	pyridoxal 5'-phosphate binding site [chemical binding]; other site
929506001633	catalytic residue [active]
929506001634	Homoserine O-succinyltransferase; Region: HTS; pfam04204
929506001635	Type 1 glutamine amidotransferase (GATase1)-like domain found in homoserine trans-succinylase (HTS); Region: GATase1_HTS; cd03131
929506001636	proposed active site lysine [active]
929506001637	conserved cys residue [active]
929506001638	Uncharacterized conserved protein [Function unknown]; Region: COG1284
929506001639	Uncharacterized BCR, YitT family COG1284; Region: DUF161; pfam02588
929506001640	Uncharacterized protein conserved in bacteria (DUF2179); Region: DUF2179; pfam10035
929506001641	DctM-like transporters; Region: DctM; pfam06808
929506001642	Sensory domain found in PocR; Region: PocR; pfam10114
929506001643	Predicted sensor domain [Signal transduction mechanisms / Transcription]; Region: PocR; COG4936
929506001644	Histidine kinase; Region: His_kinase; pfam06580
929506001645	helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342
929506001646	Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165
929506001647	Alcohol dehydrogenase, class IV [Energy production and conversion]; Region: EutG; COG1454
929506001648	Lactadehyde:propanediol oxidoreductase (LPO) catalyzes the interconversion between L-lactaldehyde and L-1,2-propanediol in Escherichia coli and other enterobacteria; Region: LPO; cd08176
929506001649	dimer interface [polypeptide binding]; other site
929506001650	active site
929506001651	metal binding site [ion binding]; metal-binding site
929506001652	glycyl radical enzyme, PFL2/glycerol dehydratase family; Region: PFL2-3; TIGR01774
929506001653	Pyruvate formate lyase 2 and related enzymes; Region: PFL2_DhaB_BssA; cd01677
929506001654	dimer interface [polypeptide binding]; other site
929506001655	active site
929506001656	glycine loop; other site
929506001657	glycyl-radical enzyme activating protein family; Region: PFLE_PFLC; TIGR02494
929506001658	The HCP family of iron-sulfur proteins includes hybrid cluster protein (HCP), acetyl-CoA synthase (ACS), and carbon monoxide dehydrogenase (CODH), all of which contain [Fe4-S4] metal clusters at their active sites. These proteins have a conserved...; Region: HCP_like; cl14655
929506001659	Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335
929506001660	FeS/SAM binding site; other site
929506001661	Ferritin-like superfamily of diiron-containing four-helix-bundle proteins; Region: Ferritin_like; cl00264
929506001662	dinuclear metal binding motif [ion binding]; other site
929506001663	Protease prsW family; Region: PrsW-protease; pfam13367
929506001664	DNA-binding transcriptional repressor PuuR; Provisional; Region: PRK09943
929506001665	Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093
929506001666	non-specific DNA binding site [nucleotide binding]; other site
929506001667	salt bridge; other site
929506001668	sequence-specific DNA binding site [nucleotide binding]; other site
929506001669	Cupin domain; Region: Cupin_2; pfam07883
929506001670	ABC-type spermidine/putrescine transport systems, ATPase components [Amino acid transport and metabolism]; Region: PotA; COG3842
929506001671	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
929506001672	Walker A/P-loop; other site
929506001673	ATP binding site [chemical binding]; other site
929506001674	Q-loop/lid; other site
929506001675	ABC transporter signature motif; other site
929506001676	Walker B; other site
929506001677	D-loop; other site
929506001678	H-loop/switch region; other site
929506001679	TOBE domain; Region: TOBE_2; pfam08402
929506001680	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
929506001681	putative PBP binding loops; other site
929506001682	ABC-ATPase subunit interface; other site
929506001683	ABC-type spermidine/putrescine transport system, permease component II [Amino acid transport and metabolism]; Region: PotC; COG1177
929506001684	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
929506001685	dimer interface [polypeptide binding]; other site
929506001686	conserved gate region; other site
929506001687	putative PBP binding loops; other site
929506001688	ABC-ATPase subunit interface; other site
929506001689	Spermidine/putrescine-binding periplasmic protein [Amino acid transport and metabolism]; Region: PotD; COG0687
929506001690	Bacterial extracellular solute-binding protein; Region: SBP_bac_6; pfam13343
929506001691	UDP-glucose 4-epimerase [Cell envelope biogenesis, outer membrane]; Region: GalE; COG1087
929506001692	UDP-glucose 4 epimerase, subgroup 1, extended (e) SDRs; Region: UDP_G4E_1_SDR_e; cd05247
929506001693	NAD binding site [chemical binding]; other site
929506001694	homodimer interface [polypeptide binding]; other site
929506001695	active site
929506001696	substrate binding site [chemical binding]; other site
929506001697	Ligand binding domain of the LacI tanscriptional regulator family belonging to the type I periplasmic-binding fold protein superfamily; Region: PBP1_LacI_sugar_binding_like; cd06267
929506001698	dimerization interface [polypeptide binding]; other site
929506001699	Periplasmic binding proteins and sugar binding domain of LacI family; Region: Peripla_BP_1; pfam00532
929506001700	ligand binding site [chemical binding]; other site
929506001701	galactokinase; Provisional; Region: PRK05322
929506001702	Galactokinase galactose-binding signature; Region: GalKase_gal_bdg; pfam10509
929506001703	GHMP kinases N terminal domain; Region: GHMP_kinases_N; pfam00288
929506001704	GHMP kinases C terminal; Region: GHMP_kinases_C; pfam08544
929506001705	Domain of unknown function (DUF4380); Region: DUF4380; pfam14315
929506001706	galactose-1-phosphate uridylyltransferase; Provisional; Region: PRK05270
929506001707	Galactose-1-phosphate uridyl transferase, N-terminal domain; Region: GalP_UDP_transf; pfam01087
929506001708	Galactose-1-phosphate uridyl transferase, C-terminal domain; Region: GalP_UDP_tr_C; pfam02744
929506001709	putative transporter; Provisional; Region: PRK10484
929506001710	uncharacterized SLC5 subfamily, Escherichia coli YidK-like; solute binding domain; Region: SLC5sbd_YidK; cd10328
929506001711	Na binding site [ion binding]; other site
929506001712	Alpha-galactosidase [Carbohydrate transport and metabolism]; Region: GalA; COG3345
929506001713	Melibiase; Region: Melibiase; pfam02065
929506001714	phosphoglucomutase-2-like protein; Provisional; Region: PTZ00150
929506001715	This CD includes PGM2 (phosphoglucomutase 2) and PGM2L1 (phosphoglucomutase 2-like 1). The mammalian PGM2 is thought to be a phosphopentomutase that catalyzes the conversion of the nucleoside breakdown products, ribose-1-phosphate and...; Region: PGM2; cd05799
929506001716	active site
929506001717	substrate binding site [chemical binding]; other site
929506001718	metal binding site [ion binding]; metal-binding site
929506001719	Late competence development protein ComFB; Region: ComFB; pfam10719
929506001720	Zn-dependent dipeptidase, microsomal dipeptidase homolog [Amino acid transport and metabolism]; Region: COG2355
929506001721	renal dipeptidase (rDP), best studied in mammals and also called membrane or microsomal dipeptidase, is a membrane-bound glycoprotein hydrolyzing dipeptides and is involved in hydrolytic metabolism of penem and carbapenem beta-lactam antibiotics; Region: rDP_like; cd01301
929506001722	active site
929506001723	dimer interface [polypeptide binding]; other site
929506001724	asparaginyl-tRNA synthetase; Validated; Region: asnC; PRK03932
929506001725	EcAsnRS_like_N: N-terminal, anticodon recognition domain of the type found in Escherichia coli asparaginyl-tRNA synthetase (AsnRS) and, in Arabidopsis thaliana and Saccharomyces cerevisiae mitochondrial (mt) AsnRS. This domain is a beta-barrel domain (OB...; Region: EcAsnRS_like_N; cd04318
929506001726	putative dimer interface [polypeptide binding]; other site
929506001727	putative anticodon binding site; other site
929506001728	Asx tRNA synthetase (AspRS/AsnRS) class II core domain.  Assignment to class II aminoacyl-tRNA synthetases (aaRS) based upon its structure and the presence of three characteristic sequence motifs in the core domain. This family includes AsnRS as well as...; Region: AsxRS_core; cd00776
929506001729	homodimer interface [polypeptide binding]; other site
929506001730	motif 1; other site
929506001731	motif 2; other site
929506001732	active site
929506001733	motif 3; other site
929506001734	helicase-exonuclease AddAB, AddB subunit; Region: addB_Gpos; TIGR02773
929506001735	PD-(D/E)XK nuclease superfamily; Region: PDDEXK_1; pfam12705
929506001736	helicase-exonuclease AddAB, AddA subunit, Firmicutes type; Region: addA_Gpos; TIGR02785
929506001737	Part of AAA domain; Region: AAA_19; pfam13245
929506001738	Family description; Region: UvrD_C_2; pfam13538
929506001739	PD-(D/E)XK nuclease superfamily; Region: PDDEXK_1; pfam12705
929506001740	3'-5' exoribonuclease YhaM; Provisional; Region: PRK13480
929506001741	YhaM_OBF_like: A subfamily of OB folds similar to that found in Bacillus subtilis YhaM and Staphylococcus aureus cmp-binding factor-1 (SaCBF1). Both these proteins are 3'-to-5'exoribonucleases. YhaM requires Mn2+ or Co2+ for activity and is...; Region: YhaM_OBF_like; cd04492
929506001742	generic binding surface II; other site
929506001743	generic binding surface I; other site
929506001744	Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077
929506001745	Zn2+ binding site [ion binding]; other site
929506001746	Mg2+ binding site [ion binding]; other site
929506001747	Disaggregatase related repeat; Region: Disaggr_repeat; pfam06848
929506001748	Carbohydrate binding domain; Region: CBM_4_9; pfam02018
929506001749	Rhs family protein [Cell envelope biogenesis, outer membrane]; Region: RhsA; COG3209
929506001750	Concanavalin A-like lectin/glucanases superfamily; Region: Laminin_G_3; pfam13385
929506001751	RHS repeat-associated core domain; Region: Rhs_assc_core; TIGR03696
929506001752	RHS repeat-associated core domain; Region: Rhs_assc_core; TIGR03696
929506001753	HNH nucleases; HNH endonuclease signature which is found in viral, prokaryotic, and eukaryotic proteins. The alignment includes members of the large group of homing endonucleases, yeast intron 1 protein, MutS, as well as bacterial colicins, pyocins, and...; Region: HNHc; cd00085
929506001754	active site
929506001755	Uncharacterized protein conserved in Bacteroidetes; Region: Bacuni_01323_like; cd12871
929506001756	RHS repeat-associated core domain; Region: Rhs_assc_core; TIGR03696
929506001757	PD-(D/E)XK nuclease family transposase; Region: PDDEXK_2; pfam12784
929506001758	conserved hypothetical protein (putative transposase or invertase); Region: T_den_put_tspse; TIGR01784
929506001759	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3677
929506001760	InsA N-terminal domain; Region: Zn_Tnp_IS1; pfam03811
929506001761	DDE domain; Region: DDE_Tnp_IS240; pfam13610
929506001762	Integrase core domain; Region: rve; pfam00665
929506001763	Integrase core domain; Region: rve_3; pfam13683
929506001764	SUKH-3 immunity protein; Region: SUKH-3; pfam14433
929506001765	Protein of unknown function (DUF1629); Region: DUF1629; pfam07791
929506001766	glycogen synthase; Provisional; Region: glgA; PRK00654
929506001767	This family is most closely related to the GT1 family of glycosyltransferases. Glycogen synthase catalyzes the formation and elongation of the alpha-1,4-glucose backbone using ADP-glucose, the second and key step of glycogen biosynthesis. This family...; Region: GT1_Glycogen_synthase_DULL1_like; cd03791
929506001768	ADP-binding pocket [chemical binding]; other site
929506001769	homodimer interface [polypeptide binding]; other site
929506001770	This is a family of oligosaccharide phosphorylases. It includes yeast and mammalian glycogen phosphorylases, plant starch/glucan phosphorylase, as well as the maltodextrin phosphorylases of bacteria. The members of this family catalyze the breakdown of...; Region: GT1_Glycogen_Phosphorylase; cd04300
929506001771	homodimer interface [polypeptide binding]; other site
929506001772	glycogen/starch/alpha-glucan phosphorylases; Region: P_ylase; TIGR02093
929506001773	active site pocket [active]
929506001774	Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118
929506001775	Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118
929506001776	Protein of unknown function (DUF1292); Region: DUF1292; cl01608
929506001777	Ferredoxin [Energy production and conversion]; Region: Fer; COG1141
929506001778	Fusaric acid resistance protein-like; Region: FUSC_2; pfam13515
929506001779	Elongator protein 3, MiaB family, Radical SAM; Region: Elp3; smart00729
929506001780	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
929506001781	phage shock protein operon transcriptional activator; Provisional; Region: pspF; PRK11608
929506001782	Walker A motif; other site
929506001783	ATP binding site [chemical binding]; other site
929506001784	Walker B motif; other site
929506001785	arginine finger; other site
929506001786	Bacterial regulatory protein, Fis family; Region: HTH_8; pfam02954
929506001787	PAS domain; Region: PAS_9; pfam13426
929506001788	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
929506001789	putative active site [active]
929506001790	heme pocket [chemical binding]; other site
929506001791	ATPases associated with a variety of cellular activities; Region: AAA; smart00382
929506001792	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
929506001793	Walker A motif; other site
929506001794	ATP binding site [chemical binding]; other site
929506001795	Walker B motif; other site
929506001796	arginine finger; other site
929506001797	phenylhydantoinase; Validated; Region: PRK08323
929506001798	D-hydantoinases (D-HYD) also called dihydropyrimidases (DHPase) and related proteins; DHPases are a family of enzymes that catalyze the reversible hydrolytic ring opening of the amide bond in five- or six-membered cyclic diamides, like dihydropyrimidine...; Region: D-HYD; cd01314
929506001799	tetramer interface [polypeptide binding]; other site
929506001800	active site
929506001801	Protein of unknown function (DUF1097); Region: DUF1097; pfam06496
929506001802	peptidase; Reviewed; Region: PRK13004
929506001803	Zinc peptidases M18, M20, M28, and M42; Region: Zinc_peptidase_like; cl14876
929506001804	metal binding site [ion binding]; metal-binding site
929506001805	Predicted acyl-CoA transferases/carnitine dehydratase [Energy production and conversion]; Region: CaiB; COG1804
929506001806	CoA-transferase family III; Region: CoA_transf_3; pfam02515
929506001807	The hotdog fold was initially identified in the E. coli FabA (beta-hydroxydecanoyl-acyl carrier protein (ACP)-dehydratase) structure and subsequently in 4HBT (4-hydroxybenzoyl-CoA thioesterase) from Pseudomonas. A number of other seemingly unrelated...; Region: hot_dog; cd03440
929506001808	active site 2 [active]
929506001809	active site 1 [active]
929506001810	The hotdog fold was initially identified in the E. coli FabA (beta-hydroxydecanoyl-acyl carrier protein (ACP)-dehydratase) structure and subsequently in 4HBT (4-hydroxybenzoyl-CoA thioesterase) from Pseudomonas. A number of other seemingly unrelated...; Region: hot_dog; cd03440
929506001811	active site 2 [active]
929506001812	active site 1 [active]
929506001813	Exonuclease-Endonuclease-Phosphatase (EEP) domain superfamily; Region: EEP; cl00490
929506001814	DNA repair exonuclease [DNA replication, recombination, and repair]; Region: SbcD; COG0420
929506001815	Mre11 nuclease, N-terminal metallophosphatase domain; Region: MPP_Mre11_N; cd00840
929506001816	active site
929506001817	metal binding site [ion binding]; metal-binding site
929506001818	DNA binding site [nucleotide binding]
929506001819	Type 5 capsule protein repressor C-terminal domain; Region: SbcD_C; pfam12320
929506001820	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
929506001821	AAA domain; Region: AAA_23; pfam13476
929506001822	Walker A/P-loop; other site
929506001823	ATP binding site [chemical binding]; other site
929506001824	Q-loop/lid; other site
929506001825	ATPase involved in DNA repair [DNA replication, recombination, and repair]; Region: SbcC; COG0419
929506001826	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
929506001827	ABC transporter signature motif; other site
929506001828	Walker B; other site
929506001829	D-loop; other site
929506001830	H-loop/switch region; other site
929506001831	Na+/H+ antiporter [Energy production and conversion]; Region: NhaC; COG1757
929506001832	Carboxypeptidase regulatory-like domain; Region: CarboxypepD_reg; pfam13620
929506001833	Carboxypeptidase regulatory-like domain; Region: CarboxypepD_reg; pfam13620
929506001834	Carboxypeptidase regulatory-like domain; Region: CarboxypepD_reg; pfam13620
929506001835	Cache domain; Region: Cache_1; pfam02743
929506001836	Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer); Region: MA; smart00283
929506001837	Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386
929506001838	dimer interface [polypeptide binding]; other site
929506001839	putative CheW interface [polypeptide binding]; other site
929506001840	Serine dehydratase alpha chain; Region: SDH_alpha; cl12120
929506001841	L-serine deaminase [Amino acid transport and metabolism]; Region: SdaA; COG1760
929506001842	L-serine dehydratase, iron-sulfur-dependent, beta subunit; Region: sda_beta; TIGR00719
929506001843	Serine dehydratase beta chain; Region: SDH_beta; pfam03315
929506001844	ACT domains are commonly involved in specifically binding an amino acid or other small ligand leading to regulation of the enzyme; Region: ACT; cl09141
929506001845	Putative small multi-drug export protein; Region: Sm_multidrug_ex; pfam06695
929506001846	Putative regulator of cell autolysis [Signal transduction mechanisms]; Region: LytS; COG3275
929506001847	5TMR of 5TMR-LYT; Region: 5TM-5TMR_LYT; pfam07694
929506001848	Histidine kinase; Region: His_kinase; pfam06580
929506001849	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
929506001850	ATP binding site [chemical binding]; other site
929506001851	Mg2+ binding site [ion binding]; other site
929506001852	G-X-G motif; other site
929506001853	Response regulator of the LytR/AlgR family [Transcription / Signal transduction mechanisms]; Region: LytT; COG3279
929506001854	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
929506001855	active site
929506001856	phosphorylation site [posttranslational modification]
929506001857	intermolecular recognition site; other site
929506001858	dimerization interface [polypeptide binding]; other site
929506001859	LytTr DNA-binding domain; Region: LytTR; smart00850
929506001860	Carbon starvation protein, predicted membrane protein [Signal transduction mechanisms]; Region: CstA; COG1966
929506001861	Carbon starvation protein CstA; Region: CstA; pfam02554
929506001862	Carbon starvation protein CstA; Region: CstA; pfam02554
929506001863	C-terminal domain on CstA (DUF4161); Region: DUF4161; pfam13722
929506001864	4'-phosphopantetheinyl transferase; Provisional; Region: acpS; PRK00070
929506001865	YjeF-related protein N-terminus; Region: YjeF_N; pfam03853
929506001866	B.subtilis YXKO protein of unknown function and related proteins. Based on the conservation of the ATP binding site, the substrate binding site and the Mg2+binding site and structural homology this group is a member of the ribokinase-like superfamily; Region: YXKO-related; cd01171
929506001867	putative substrate binding site [chemical binding]; other site
929506001868	putative ATP binding site [chemical binding]; other site
929506001869	Outer membrane lipoprotein-sorting protein [Cell envelope biogenesis, outer membrane]; Region: LolA; COG2834
929506001870	alanine racemase; Reviewed; Region: alr; PRK00053
929506001871	Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzyme Alanine Racemase; Region: PLPDE_III_AR; cd00430
929506001872	active site
929506001873	pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site
929506001874	dimer interface [polypeptide binding]; other site
929506001875	substrate binding site [chemical binding]; other site
929506001876	catalytic residues [active]
929506001877	PemK-like protein; Region: PemK; pfam02452
929506001878	transketolase; Reviewed; Region: PRK05899
929506001879	Thiamine pyrophosphate (TPP) family, Transketolase (TK) subfamily, TPP-binding module; TK catalyzes the transfer of a two-carbon unit from ketose phosphates to aldose phosphates. In heterotrophic organisms, TK provides a link between glycolysis and the...; Region: TPP_TK; cd02012
929506001880	TPP-binding site [chemical binding]; other site
929506001881	dimer interface [polypeptide binding]; other site
929506001882	Transketolase, C-terminal subunit [Carbohydrate transport and metabolism]; Region: COG3958
929506001883	Pyrimidine (PYR) binding domain of 1-deoxy-D-xylulose-5-phosphate synthase (DXS), transketolase (TK), and related proteins; Region: TPP_PYR_DXS_TK_like; cd07033
929506001884	PYR/PP interface [polypeptide binding]; other site
929506001885	dimer interface [polypeptide binding]; other site
929506001886	TPP binding site [chemical binding]; other site
929506001887	Transketolase, C-terminal domain; Region: Transketolase_C; pfam02780
929506001888	Uncharacterized conserved protein [Function unknown]; Region: COG1284
929506001889	Uncharacterized BCR, YitT family COG1284; Region: DUF161; pfam02588
929506001890	Uncharacterized protein conserved in bacteria (DUF2179); Region: DUF2179; pfam10035
929506001891	Predicted ATPase involved in cell division [Cell division and chromosome partitioning]; Region: FtsE; COG2884
929506001892	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
929506001893	Walker A/P-loop; other site
929506001894	ATP binding site [chemical binding]; other site
929506001895	Q-loop/lid; other site
929506001896	ABC transporter signature motif; other site
929506001897	Walker B; other site
929506001898	D-loop; other site
929506001899	H-loop/switch region; other site
929506001900	Cell division protein [Cell division and chromosome partitioning]; Region: FtsX; COG2177
929506001901	cell division ABC transporter subunit FtsX; Provisional; Region: ftsX; PRK11026
929506001902	C-terminal processing peptidase family S41; Region: Peptidase_S41; cl02526
929506001903	C-terminal peptidase (prc); Region: prc; TIGR00225
929506001904	PDZ domain of C-terminal processing-, tail-specific-, and tricorn proteases, which function in posttranslational protein processing, maturation, and disassembly or degradation, in Bacteria, Archaea, and plant chloroplasts. May be responsible for...; Region: PDZ_CTP_protease; cd00988
929506001905	protein binding site [polypeptide binding]; other site
929506001906	C-terminal processing peptidase; serine protease family S41; Region: Peptidase_S41_CPP; cd07560
929506001907	Catalytic dyad [active]
929506001908	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain [Posttranslational modification, protein turnover, chaperones]; Region: DegQ; COG0265
929506001909	PDZ domain of tryspin-like serine proteases, such as DegP/HtrA, which are oligomeric proteins involved in heat-shock response, chaperone function, and apoptosis. May be responsible for substrate recognition and/or binding, as most PDZ domains bind...; Region: PDZ_serine_protease; cd00987
929506001910	excinuclease ABC subunit B; Provisional; Region: PRK05298
929506001911	DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046
929506001912	ATP binding site [chemical binding]; other site
929506001913	Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079
929506001914	nucleotide binding region [chemical binding]; other site
929506001915	ATP-binding site [chemical binding]; other site
929506001916	Ultra-violet resistance protein B; Region: UvrB; pfam12344
929506001917	UvrB/uvrC motif; Region: UVR; pfam02151
929506001918	excinuclease ABC subunit A; Reviewed; Region: uvrA; PRK00349
929506001919	ATP-binding cassette domain I of the excision repair protein UvrA; Region: ABC_UvrA_I; cd03270
929506001920	ATP-binding cassette domain I of the excision repair protein UvrA; Region: ABC_UvrA_I; cd03270
929506001921	ATP-binding cassette domain II of the excision repair protein UvrA; Region: ABC_UvrA_II; cd03271
929506001922	FOG: FHA domain [Signal transduction mechanisms]; Region: COG1716
929506001923	Forkhead associated domain (FHA); found in eukaryotic and prokaryotic proteins. Putative nuclear signalling domain. FHA domains may bind phosphothreonine, phosphoserine and sometimes phosphotyrosine. In eukaryotes, many FHA domain-containing proteins...; Region: FHA; cd00060
929506001924	phosphopeptide binding site; other site
929506001925	Bacterial cell division membrane protein [Cell division and chromosome partitioning]; Region: FtsW; COG0772
929506001926	Penicillin-binding Protein dimerisation domain; Region: PBP_dimer; pfam03717
929506001927	Penicillin binding protein transpeptidase domain; Region: Transpeptidase; pfam00905
929506001928	Predicted membrane-bound metal-dependent hydrolase (DUF457); Region: DUF457; pfam04307
929506001929	excinuclease ABC subunit C; Validated; Region: uvrC; PRK00558
929506001930	Catalytic GIY-YIG domain of nucleotide excision repair endonucleases UvrC, Cho, and similar proteins; Region: GIY-YIG_UvrC_Cho; cd10434
929506001931	GIY-YIG motif/motif A; other site
929506001932	active site
929506001933	catalytic site [active]
929506001934	putative DNA binding site [nucleotide binding]; other site
929506001935	metal binding site [ion binding]; metal-binding site
929506001936	UvrB/uvrC motif; Region: UVR; pfam02151
929506001937	UvrC Helix-hairpin-helix N-terminal; Region: UvrC_HhH_N; pfam08459
929506001938	putative hydrolase; Validated; Region: PRK09248
929506001939	Polymerase and Histidinol Phosphatase domain of Ycdx like; Region: PHP_HisPPase_Ycdx_like; cd07437
929506001940	active site
929506001941	UDP-N-acetylenolpyruvoylglucosamine reductase; Provisional; Region: murB; PRK13905
929506001942	FAD binding domain; Region: FAD_binding_4; pfam01565
929506001943	UDP-N-acetylenolpyruvoylglucosamine reductase, C-terminal domain; Region: MurB_C; pfam02873
929506001944	glmZ(sRNA)-inactivating NTPase; Provisional; Region: PRK05416
929506001945	AAA domain; Region: AAA_33; pfam13671
929506001946	conserved hypothetical protein, cofD-related; Region: CofD_related; TIGR01826
929506001947	family of mostly uncharacterized proteins similar to B.subtilis YvcK; Region: YvcK_like; cd07187
929506001948	phosphate binding site [ion binding]; other site
929506001949	putative substrate binding pocket [chemical binding]; other site
929506001950	dimer interface [polypeptide binding]; other site
929506001951	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG1481
929506001952	Sporulation Regulator WhiA N terminal; Region: WhiA_N; pfam10298
929506001953	Predicted transcriptional regulator containing CBS domains [Transcription]; Region: COG4109
929506001954	Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cl17414
929506001955	DNA-binding site [nucleotide binding]; DNA binding site
929506001956	DRTGG domain; Region: DRTGG; pfam07085
929506001957	The CBS domain, named after human CBS, is a small domain originally identified in cystathionine beta-synthase and is subsequently found in a wide range of different proteins. CBS domains usually occur in tandem repeats. They associate to form a so-called...; Region: CBS_pair; cl15354
929506001958	Thioesterase II (TEII) is thought to regenerate misprimed nonribosomal peptide synthetases (NRPSs) as well as modular polyketide synthases (PKSs) by hydrolyzing acetyl groups bound to the peptidyl carrier protein (PCP) and acyl carrier protein (ACP)...; Region: Thioesterase_II; cd00556
929506001959	active site
929506001960	dimer interface [polypeptide binding]; other site
929506001961	Asparagine synthetase (aspartate-ammonia ligase) (AsnA) catalyses the conversion of L-aspartate to L-asparagine in the presence of ATP and ammonia.  AsnA is a homodimeric enzyme which is structurally similiar to the catalytic core domain of class II...; Region: AsnA; cd00645
929506001962	dimer interface [polypeptide binding]; other site
929506001963	active site
929506001964	Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745
929506001965	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
929506001966	active site
929506001967	phosphorylation site [posttranslational modification]
929506001968	intermolecular recognition site; other site
929506001969	dimerization interface [polypeptide binding]; other site
929506001970	Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383
929506001971	DNA binding site [nucleotide binding]
929506001972	Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642
929506001973	Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225
929506001974	dimerization interface [polypeptide binding]; other site
929506001975	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
929506001976	dimer interface [polypeptide binding]; other site
929506001977	phosphorylation site [posttranslational modification]
929506001978	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
929506001979	ATP binding site [chemical binding]; other site
929506001980	Mg2+ binding site [ion binding]; other site
929506001981	G-X-G motif; other site
929506001982	Protein of unknown function (DUF3919); Region: DUF3919; pfam13057
929506001983	Bacterial extracellular solute-binding protein; Region: SBP_bac_1; cl17199
929506001984	Bacterial extracellular solute-binding protein; Region: SBP_bac_11; pfam13531
929506001985	sn-glycerol-3-phosphate transporter; Provisional; Region: glpT; PRK11273
929506001986	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
929506001987	putative substrate translocation pore; other site
929506001988	Peptidase family M9 N-terminal; Region: Peptidase_M9_N; pfam08453
929506001989	Peptidase Gluzincin family (thermolysin-like proteinases, TLPs) includes peptidases M1, M2, M3, M4, M13, M32 and M36 (fungalysins); Region: GluZincin; cl14813
929506001990	Bacterial pre-peptidase C-terminal domain; Region: PPC; pfam04151
929506001991	Bacterial pre-peptidase C-terminal domain; Region: PPC; pfam04151
929506001992	DNA polymerase III DnaE; Reviewed; Region: dnaE; PRK06826
929506001993	Polymerase and Histidinol Phosphatase domain of alpha-subunit of bacterial polymerase III DnaE3; Region: PHP_PolIIIA_DnaE3; cd12113
929506001994	active site
929506001995	PHP Thumb interface [polypeptide binding]; other site
929506001996	metal binding site [ion binding]; metal-binding site
929506001997	DnaE_OBF: A subfamily of OB folds corresponding to the C-terminal OB-fold nucleic acid binding domain of Thermus aquaticus and Escherichia coli type C replicative DNA polymerase III alpha subunit (DnaE). The DNA polymerase holoenzyme of E. coli contains...; Region: DnaE_OBF; cd04485
929506001998	generic binding surface II; other site
929506001999	generic binding surface I; other site
929506002000	6-phosphofructokinase; Provisional; Region: PRK03202
929506002001	6-phosphofructokinase; Region: PFKA_ATP; TIGR02482
929506002002	active site
929506002003	ADP/pyrophosphate binding site [chemical binding]; other site
929506002004	dimerization interface [polypeptide binding]; other site
929506002005	allosteric effector site; other site
929506002006	fructose-1,6-bisphosphate binding site; other site
929506002007	Pyruvate kinase [Carbohydrate transport and metabolism]; Region: PykF; COG0469
929506002008	Pyruvate kinase (PK):  Large allosteric enzyme that regulates glycolysis through binding of the substrate, phosphoenolpyruvate, and one or more allosteric effectors. Like other allosteric enzymes, PK has a high substrate affinity R state and a low...; Region: Pyruvate_Kinase; cl17342
929506002009	domain interfaces; other site
929506002010	active site
929506002011	Predicted RNA-binding protein, contains TRAM domain [General function prediction only]; Region: COG3269
929506002012	SAM-dependent methyltransferases related to tRNA (uracil-5-)-methyltransferase [Translation, ribosomal structure and biogenesis]; Region: TrmA; COG2265
929506002013	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
929506002014	S-adenosylmethionine binding site [chemical binding]; other site
929506002015	Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165
929506002016	helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342
929506002017	Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165
929506002018	RNA polymerase sigma factor, sigma-70 family; Region: sigma70-ECF; TIGR02937
929506002019	Sigma-70 region 2; Region: Sigma70_r2; pfam04542
929506002020	Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171
929506002021	DNA binding residues [nucleotide binding]
929506002022	ABC-type multidrug transport system, ATPase component [Defense mechanisms]; Region: CcmA; COG1131
929506002023	ABC-type multidrug transport system, ATPase component; Region: ABC_drug_resistance_like; cd03264
929506002024	Walker A/P-loop; other site
929506002025	ATP binding site [chemical binding]; other site
929506002026	Q-loop/lid; other site
929506002027	ABC transporter signature motif; other site
929506002028	Walker B; other site
929506002029	D-loop; other site
929506002030	H-loop/switch region; other site
929506002031	ABC-2 family transporter protein; Region: ABC2_membrane_4; pfam12730
929506002032	Small, acid-soluble spore proteins, alpha/beta type; Region: SASP; pfam00269
929506002033	Trypsin-like peptidase domain; Region: Trypsin_2; pfam13365
929506002034	Trypsin-like peptidase domain; Region: Trypsin_2; pfam13365
929506002035	YeiC-like sugar kinase.  Found in eukaryotes and bacteria, YeiC-like kinase is part of the ribokinase/pfkB sugar kinase superfamily. Its oligomerization state is unknown at this time; Region: YeiC_kinase_like; cd01941
929506002036	Sugar kinases, ribokinase family [Carbohydrate transport and metabolism]; Region: RbsK; COG0524
929506002037	substrate binding site [chemical binding]; other site
929506002038	ATP binding site [chemical binding]; other site
929506002039	Phosphoribosylanthranilate isomerase (PRAI) catalyzes the fourth step of the tryptophan biosynthesis, the conversion of N-(5'- phosphoribosyl)-anthranilate (PRA) to 1-(o-carboxyphenylamino)- 1-deoxyribulose 5-phosphate (CdRP). Most PRAIs are...; Region: PRAI; cd00405
929506002040	active site
929506002041	putative kinase; Provisional; Region: PRK09954
929506002042	Winged helix-turn-helix DNA-binding; Region: HTH_24; pfam13412
929506002043	YeiC-like sugar kinase.  Found in eukaryotes and bacteria, YeiC-like kinase is part of the ribokinase/pfkB sugar kinase superfamily. Its oligomerization state is unknown at this time; Region: YeiC_kinase_like; cd01941
929506002044	substrate binding site [chemical binding]; other site
929506002045	ATP binding site [chemical binding]; other site
929506002046	Branched-chain amino acid transport protein; Region: Branch_AA_trans; pfam05525
929506002047	GxGYxY sequence motif in domain of unknown function; Region: GxGYxYP; pfam14323
929506002048	3-dehydroquinate dehydratase [Amino acid transport and metabolism]; Region: AroD; COG0710
929506002049	Type I 3-dehydroquinase, (3-dehydroquinate dehydratase or DHQase); Region: DHQase_I; cd00502
929506002050	active site
929506002051	catalytic residue [active]
929506002052	dimer interface [polypeptide binding]; other site
929506002053	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301
929506002054	Coenzyme A binding pocket [chemical binding]; other site
929506002055	Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745
929506002056	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
929506002057	active site
929506002058	phosphorylation site [posttranslational modification]
929506002059	intermolecular recognition site; other site
929506002060	dimerization interface [polypeptide binding]; other site
929506002061	Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383
929506002062	DNA binding site [nucleotide binding]
929506002063	Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642
929506002064	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
929506002065	dimer interface [polypeptide binding]; other site
929506002066	phosphorylation site [posttranslational modification]
929506002067	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
929506002068	ATP binding site [chemical binding]; other site
929506002069	Mg2+ binding site [ion binding]; other site
929506002070	G-X-G motif; other site
929506002071	ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136
929506002072	ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255
929506002073	Walker A/P-loop; other site
929506002074	ATP binding site [chemical binding]; other site
929506002075	Q-loop/lid; other site
929506002076	ABC transporter signature motif; other site
929506002077	Walker B; other site
929506002078	D-loop; other site
929506002079	H-loop/switch region; other site
929506002080	FtsX-like permease family; Region: FtsX; pfam02687
929506002081	Sugar phosphate permease [Carbohydrate transport and metabolism]; Region: UhpC; COG2271
929506002082	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
929506002083	putative substrate translocation pore; other site
929506002084	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
929506002085	Bacterial extracellular solute-binding protein; Region: SBP_bac_11; pfam13531
929506002086	ABC-type Fe3+ transport system, periplasmic component [Inorganic ion transport and metabolism]; Region: AfuA; COG1840
929506002087	Protein of unknown function (DUF3919); Region: DUF3919; pfam13057
929506002088	Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642
929506002089	Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225
929506002090	dimerization interface [polypeptide binding]; other site
929506002091	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
929506002092	dimer interface [polypeptide binding]; other site
929506002093	phosphorylation site [posttranslational modification]
929506002094	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
929506002095	ATP binding site [chemical binding]; other site
929506002096	Mg2+ binding site [ion binding]; other site
929506002097	G-X-G motif; other site
929506002098	Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745
929506002099	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
929506002100	active site
929506002101	phosphorylation site [posttranslational modification]
929506002102	intermolecular recognition site; other site
929506002103	dimerization interface [polypeptide binding]; other site
929506002104	Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383
929506002105	DNA binding site [nucleotide binding]
929506002106	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3677
929506002107	InsA N-terminal domain; Region: Zn_Tnp_IS1; pfam03811
929506002108	DDE domain; Region: DDE_Tnp_IS240; pfam13610
929506002109	Integrase core domain; Region: rve; pfam00665
929506002110	Integrase core domain; Region: rve_3; pfam13683
929506002111	Uncharacterized conserved protein [Function unknown]; Region: COG3402
929506002112	Predicted membrane protein [Function unknown]; Region: COG3428
929506002113	Bacterial PH domain; Region: DUF304; pfam03703
929506002114	Bacterial PH domain; Region: DUF304; pfam03703
929506002115	Bacterial PH domain; Region: DUF304; pfam03703
929506002116	Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745
929506002117	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
929506002118	active site
929506002119	phosphorylation site [posttranslational modification]
929506002120	intermolecular recognition site; other site
929506002121	dimerization interface [polypeptide binding]; other site
929506002122	Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383
929506002123	DNA binding site [nucleotide binding]
929506002124	Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cl01054
929506002125	dimerization interface [polypeptide binding]; other site
929506002126	Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642
929506002127	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
929506002128	dimer interface [polypeptide binding]; other site
929506002129	phosphorylation site [posttranslational modification]
929506002130	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
929506002131	ATP binding site [chemical binding]; other site
929506002132	Mg2+ binding site [ion binding]; other site
929506002133	G-X-G motif; other site
929506002134	Outer membrane lipoprotein-sorting protein [Cell envelope biogenesis, outer membrane]; Region: LolA; COG2834
929506002135	Glutamate decarboxylase and related PLP-dependent proteins [Amino acid transport and metabolism]; Region: GadB; COG0076
929506002136	pyridoxal 5'-phosphate binding pocket [chemical binding]; other site
929506002137	catalytic residue [active]
929506002138	Predicted acyl-CoA transferases/carnitine dehydratase [Energy production and conversion]; Region: CaiB; COG1804
929506002139	CoA-transferase family III; Region: CoA_transf_3; pfam02515
929506002140	BadF/BadG/BcrA/BcrD ATPase family; Region: BcrAD_BadFG; cl17271
929506002141	benzoyl-CoA reductase, bcr type, subunit B; Region: benz_CoA_red_B; TIGR02260
929506002142	2-hydroxyglutaryl-CoA dehydratase, D-component; Region: HGD-D; pfam06050
929506002143	benzoyl-CoA reductase, subunit C; Region: benz_CoA_red_C; TIGR02263
929506002144	2-hydroxyglutaryl-CoA dehydratase, D-component; Region: HGD-D; pfam06050
929506002145	Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960
929506002146	Short chain acyl-CoA dehydrogenases and eukaryotic short/branched chain acyl-CoA dehydrogenases; Region: SCAD_SBCAD; cd01158
929506002147	FAD binding site [chemical binding]; other site
929506002148	homotetramer interface [polypeptide binding]; other site
929506002149	substrate binding pocket [chemical binding]; other site
929506002150	catalytic base [active]
929506002151	Predicted xylanase/chitin deacetylase [Carbohydrate transport and metabolism]; Region: CDA1; COG0726
929506002152	Putative catalytic NodB homology domain of PgaB, IcaB, and similar proteins which consist of a deformed (beta/alpha)8 barrel fold with 5- or 6-strands; Region: CE4_NodB_like_5s_6s; cd10918
929506002153	putative active site [active]
929506002154	putative metal binding site [ion binding]; other site
929506002155	cobalt transport protein CbiM; Validated; Region: PRK08319
929506002156	Cobalt uptake substrate-specific transmembrane region; Region: CbiM; pfam01891
929506002157	cobalt transport protein CbiN; Provisional; Region: PRK02898
929506002158	cobalt ABC transporter, permease protein CbiQ; Region: CbiQ_TIGR; TIGR02454
929506002159	cobalt transporter ATP-binding subunit; Provisional; Region: cbiO; PRK13639
929506002160	First domain of the ATP-binding cassette component of cobalt transport system; Region: ABC_cobalt_CbiO_domain1; cd03225
929506002161	Walker A/P-loop; other site
929506002162	ATP binding site [chemical binding]; other site
929506002163	Q-loop/lid; other site
929506002164	ABC transporter signature motif; other site
929506002165	Walker B; other site
929506002166	D-loop; other site
929506002167	H-loop/switch region; other site
929506002168	Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer); Region: MA; smart00283
929506002169	Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386
929506002170	dimer interface [polypeptide binding]; other site
929506002171	putative CheW interface [polypeptide binding]; other site
929506002172	solute carrier 6 subfamily, Fusobacterium nucleatum Tyt1-like; solute-binding domain; Region: SLC6sbd_Tyt1-Like; cd10336
929506002173	Na2 binding site [ion binding]; other site
929506002174	putative substrate binding site 1 [chemical binding]; other site
929506002175	Na binding site 1 [ion binding]; other site
929506002176	putative substrate binding site 2 [chemical binding]; other site
929506002177	SGNH_hydrolase, or GDSL_hydrolase, is a diverse family of lipases and esterases. The tertiary fold of the enzyme is substantially different from that of the alpha/beta hydrolase family and unique among all known hydrolases; its active site closely...; Region: SGNH_hydrolase; cl01053
929506002178	active site
929506002179	catalytic triad [active]
929506002180	oxyanion hole [active]
929506002181	Domain of unknown function (DUF4358); Region: DUF4358; pfam14270
929506002182	Predicted membrane protein involved in D-alanine export [Cell envelope biogenesis, outer membrane]; Region: DltB; COG1696
929506002183	Cell Wall Hydrolase; Region: Hydrolase_2; pfam07486
929506002184	signal peptidase I, bacterial type; Region: sigpep_I_bact; TIGR02227
929506002185	The S26 Type I signal peptidase (SPase; LepB; leader peptidase B; leader peptidase I; EC 3.4.21.89) family members are essential membrane-bound serine proteases that function to cleave the amino-terminal signal peptide extension from proteins that are...; Region: S26_SPase_I; cd06530
929506002186	Catalytic site [active]
929506002187	FtsH Extracellular; Region: FtsH_ext; pfam06480
929506002188	ATP-dependent metalloprotease FtsH; Region: FtsH_fam; TIGR01241
929506002189	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
929506002190	Walker A motif; other site
929506002191	ATP binding site [chemical binding]; other site
929506002192	Walker B motif; other site
929506002193	arginine finger; other site
929506002194	Peptidase family M41; Region: Peptidase_M41; pfam01434
929506002195	Superfamily I DNA and RNA helicases [General function prediction only]; Region: COG3973
929506002196	Part of AAA domain; Region: AAA_19; pfam13245
929506002197	Family description; Region: UvrD_C_2; pfam13538
929506002198	multidrug efflux pump VmrA; Reviewed; Region: vmrA; PRK09575
929506002199	Subfamily of the multidrug and toxic compound extrusion (MATE)-like proteins similar to Streptococcus aureus MepA; Region: MATE_MepA_like; cd13143
929506002200	hypothetical protein; Provisional; Region: PRK06851
929506002201	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
929506002202	Walker A motif; other site
929506002203	ATP binding site [chemical binding]; other site
929506002204	Walker B motif; other site
929506002205	cation diffusion facilitator family transporter; Region: CDF; TIGR01297
929506002206	Predicted Co/Zn/Cd cation transporters [Inorganic ion transport and metabolism]; Region: MMT1; COG0053
929506002207	M18 Peptidase Aspartyl aminopeptidase; Region: M18_DAP; cd05658
929506002208	Aminopeptidase I zinc metalloprotease (M18); Region: Peptidase_M18; pfam02127
929506002209	active site
929506002210	metal binding site [ion binding]; metal-binding site
929506002211	Catalytic NodB homology domain of the carbohydrate esterase 4 superfamily; Region: CE4_SF; cl15692
929506002212	Acetyltransferase (GNAT) domain; Region: Acetyltransf_3; pfam13302
929506002213	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301
929506002214	Coenzyme A binding pocket [chemical binding]; other site
929506002215	FRG domain; Region: FRG; pfam08867
929506002216	Domain of unknown function (DUF4118); Region: DUF4118; pfam13493
929506002217	Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer); Region: MA; smart00283
929506002218	Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386
929506002219	dimer interface [polypeptide binding]; other site
929506002220	putative CheW interface [polypeptide binding]; other site
929506002221	Domain of unknown function (DUF4250); Region: DUF4250; pfam14056
929506002222	Escherichia coli YfcE and related proteins, metallophosphatase domain; Region: MPP_YfcE; cd00841
929506002223	Calcineurin-like phosphoesterase; Region: Metallophos; pfam00149
929506002224	active site
929506002225	metal binding site [ion binding]; metal-binding site
929506002226	homotetramer interface [polypeptide binding]; other site
929506002227	diaminopimelate decarboxylase; Region: lysA; TIGR01048
929506002228	Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzyme Diaminopimelate Decarboxylase; Region: PLPDE_III_DapDC; cd06828
929506002229	active site
929506002230	pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site
929506002231	substrate binding site [chemical binding]; other site
929506002232	catalytic residues [active]
929506002233	dimer interface [polypeptide binding]; other site
929506002234	Protein of unknown function (DUF3131); Region: DUF3131; pfam11329
929506002235	Putative glucoamylase; Region: Glycoamylase; pfam10091
929506002236	Second GH94N domain of cyclic beta 1-2 glucan synthetase and similar domains; Region: GH94N_ChvB_NdvB_2_like; cd11753
929506002237	Cellobiose phosphorylase [Carbohydrate transport and metabolism]; Region: COG3459
929506002238	First GH94N domain of cyclic beta 1-2 glucan synthetase and similar domains; Region: GH94N_ChvB_NdvB_1_like; cd11756
929506002239	Protein of unknown function, DUF608; Region: DUF608; pfam04685
929506002240	tryptophanyl-tRNA synthetase II; Reviewed; Region: PRK12282
929506002241	catalytic core domain of tryptophanyl-tRNA synthetase; Region: TrpRS_core; cd00806
929506002242	active site
929506002243	HIGH motif; other site
929506002244	dimer interface [polypeptide binding]; other site
929506002245	KMSKS motif; other site
929506002246	sugar phosphate phosphatase; Provisional; Region: PRK10513
929506002247	Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cl17915
929506002248	active site
929506002249	motif I; other site
929506002250	motif II; other site
929506002251	Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427
929506002252	sugar phosphate phosphatase; Provisional; Region: PRK10513
929506002253	Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427
929506002254	active site
929506002255	motif I; other site
929506002256	motif II; other site
929506002257	Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427
929506002258	peptide chain release factor 3; Provisional; Region: prfC; PRK00741
929506002259	Release Factor 3 (RF3) protein involved in the terminal step of translocation in bacteria; Region: RF3; cd04169
929506002260	G1 box; other site
929506002261	putative GEF interaction site [polypeptide binding]; other site
929506002262	GTP/Mg2+ binding site [chemical binding]; other site
929506002263	Switch I region; other site
929506002264	G2 box; other site
929506002265	G3 box; other site
929506002266	Switch II region; other site
929506002267	G4 box; other site
929506002268	G5 box; other site
929506002269	RF3_II: this subfamily represents the domain II of bacterial Release Factor 3 (RF3). Termination of protein synthesis by the ribosome requires two release factor (RF) classes. The class II RF3 is a GTPase that removes class I RFs (RF1 or RF2) from the...; Region: RF3_II; cd03689
929506002270	Glycine/D-amino acid oxidases (deaminating) [Amino acid transport and metabolism]; Region: DadA; COG0665
929506002271	ECF-type riboflavin transporter, S component; Region: ECF-ribofla_trS; pfam07155
929506002272	FOG: GAF domain [Signal transduction mechanisms]; Region: FhlA; COG2203
929506002273	GAF domain; Region: GAF_3; pfam13492
929506002274	c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal    transduction mechanisms]; Region: COG2199
929506002275	Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949
929506002276	metal binding site [ion binding]; metal-binding site
929506002277	active site
929506002278	I-site; other site
929506002279	tyrosyl-tRNA synthetase; Validated; Region: PRK05912
929506002280	catalytic core domain of tyrosinyl-tRNA synthetase; Region: TyrRS_core; cd00805
929506002281	active site
929506002282	HIGH motif; other site
929506002283	dimer interface [polypeptide binding]; other site
929506002284	KMSKS motif; other site
929506002285	S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site;  Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165
929506002286	RNA binding surface [nucleotide binding]; other site
929506002287	Uncharacterized homolog of the cytoplasmic domain of flagellar protein FhlB [Function unknown]; Region: COG2257
929506002288	Deinococcus radiodurans DR1119 and related proteins, metallophosphatase domain; Region: MPP_DR1119; cd07393
929506002289	Calcineurin-like phosphoesterase; Region: Metallophos; pfam00149
929506002290	putative active site [active]
929506002291	putative metal binding site [ion binding]; other site
929506002292	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG1655
929506002293	Uncharacterized protein conserved in bacteria (DUF2225); Region: DUF2225; pfam09986
929506002294	Nucleotidyltransferase (NT) domain of RelA- and SpoT-like ppGpp synthetases and hydrolases; Region: NT_Rel-Spo_like; cd05399
929506002295	synthetase active site [active]
929506002296	NTP binding site [chemical binding]; other site
929506002297	metal binding site [ion binding]; metal-binding site
929506002298	leucyl-tRNA synthetase; Validated; Region: leuS; PRK00390
929506002299	catalytic core domain of leucyl-tRNA synthetases; Region: LeuRS_core; cd00812
929506002300	HIGH motif; other site
929506002301	Leucyl-tRNA synthetase, Domain 2; Region: tRNA-synt_1_2; pfam13603
929506002302	nucleotidyl transferase superfamily; Region: nt_trans; cl00015
929506002303	active site
929506002304	KMSKS motif; other site
929506002305	Anticodon-binding domain of bacterial and eukaryotic mitochondrial leucyl tRNA synthetases; Region: Anticodon_Ia_Leu_BEm; cd07958
929506002306	tRNA binding surface [nucleotide binding]; other site
929506002307	30S ribosomal protein S1; Reviewed; Region: rpsA; PRK06676
929506002308	S1_RPS1_repeat_ec1_hs1: Ribosomal protein S1 (RPS1) domain. RPS1 is a component of the small ribosomal subunit thought to be involved in the recognition and binding of mRNA's during translation initiation. The bacterial RPS1 domain architecture...; Region: S1_RPS1_repeat_ec1_hs1; cd05687
929506002309	RNA binding site [nucleotide binding]; other site
929506002310	S1_RPS1_repeat_ec2_hs2: Ribosomal protein S1 (RPS1) domain. RPS1 is a component of the small ribosomal subunit thought to be involved in the recognition and binding of mRNA's during translation initiation. The bacterial RPS1 domain architecture...; Region: S1_RPS1_repeat_ec2_hs2; cd04465
929506002311	RNA binding site [nucleotide binding]; other site
929506002312	S1_like: Ribosomal protein S1-like RNA-binding domain. Found in a wide variety of RNA-associated proteins. Originally identified in S1 ribosomal protein. This superfamily also contains the Cold Shock Domain (CSD), which is a homolog of the S1 domain; Region: S1_like; cl09927
929506002313	RNA binding site [nucleotide binding]; other site
929506002314	S1_RPS1_repeat_hs4: Ribosomal protein S1 (RPS1) domain. RPS1 is a component of the small ribosomal subunit thought to be involved in the recognition and binding of mRNA's during translation initiation. The bacterial RPS1 domain architecture consists...; Region: S1_RPS1_repeat_hs4; cd05692
929506002315	RNA binding site [nucleotide binding]; other site
929506002316	DnaJ domain or J-domain.  DnaJ/Hsp40 (heat shock protein 40) proteins are highly conserved and play crucial roles in protein translation, folding, unfolding, translocation, and degradation. They act primarily by stimulating the ATPase activity of Hsp70s; Region: DnaJ; cd06257
929506002317	HSP70 interaction site [polypeptide binding]; other site
929506002318	Adenylyl cyclase (AC) class IV-like, a subgroup of the CYTH-like superfamily; Region: CYTH-like_AC_IV-like; cd07890
929506002319	putative active site [active]
929506002320	putative triphosphate binding site [ion binding]; other site
929506002321	signature motif; other site
929506002322	dimer interface [polypeptide binding]; other site
929506002323	37-kD nucleoid-associated bacterial protein; Region: NA37; pfam04245
929506002324	Tagatose-1,6-bisphosphate (TBP) aldolase and related Type B Class II aldolases. TBP aldolase is a tetrameric class II aldolase that catalyzes the reversible condensation of dihydroxyacetone phosphate with glyceraldehyde 3-phsophate to produce tagatose 1; Region: TBP_aldolase_IIB; cd00947
929506002325	fructose-bisphosphate aldolase; Provisional; Region: PRK09197
929506002326	intersubunit interface [polypeptide binding]; other site
929506002327	active site
929506002328	zinc binding site [ion binding]; other site
929506002329	Na+ binding site [ion binding]; other site
929506002330	Predicted membrane protein [Function unknown]; Region: COG2323
929506002331	TGS _ThrRS_N:  ThrRS (threonyl-tRNA Synthetase)  is a class II tRNA synthetase that couples threonine to its cognate tRNA.  In addition to its catalytic and anticodon-binding domains, ThrRS has an N-terminal TGS domain, named after the ThrRS, GTPase, and...; Region: TGS_ThrRS_N; cd01667
929506002332	RecA-like NTPases. This family includes the NTP binding domain of F1 and V1 H+ATPases, DnaB and related helicases as well as bacterial RecA and related eukaryotic and archaeal recombinases. This group also includes bacterial conjugation proteins and...; Region: RecA-like_NTPases; cl17233
929506002333	Uridine kinase [Nucleotide transport and metabolism]; Region: Udk; COG0572
929506002334	Uridine monophosphate kinase_like (UMPK_like) is a family of proteins highly similar to the uridine monophosphate kinase (UMPK, EC 2.7.1.48), also known as uridine kinase or uridine-cytidine kinase (UCK); Region: UMPK_like; cd02028
929506002335	active site
929506002336	Walker A motif; other site
929506002337	CDP-alcohol phosphatidyltransferase; Region: CDP-OH_P_transf; pfam01066
929506002338	CDP-diacylglycerol--serine O-phosphatidyltransferase; Region: pssA; TIGR00473
929506002339	FOG: CBS domain [General function prediction only]; Region: COG0517
929506002340	The CBS domain, named after human CBS, is a small domain originally identified in cystathionine beta-synthase and is subsequently found in a wide range of different proteins. CBS domains usually occur in tandem repeats. They associate to form a so-called...; Region: CBS_pair_9; cd04622
929506002341	putative lipid kinase; Reviewed; Region: PRK13059
929506002342	Diacylglycerol kinase catalytic domain; Region: DAGK_cat; pfam00781
929506002343	Radical SAM N-terminal; Region: Radical_SAM_N; pfam08497
929506002344	hypothetical protein; Provisional; Region: PRK00955
929506002345	Domain of unknown function (DUF3362); Region: DUF3362; pfam11842
929506002346	Mg/Co/Ni transporter MgtE (contains CBS domain) [Inorganic ion transport and metabolism]; Region: MgtE; COG2239
929506002347	MgtE intracellular N domain; Region: MgtE_N; smart00924
929506002348	This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domain in the magnesium transporter, MgtE.  MgtE and its homologs are found in eubacteria, archaebacteria, and eukaryota. Members of this family transport Mg2+ or other...; Region: CBS_pair_Mg_transporter; cd04606
929506002349	spore cortex-lytic enzyme; Region: spore_SleB; TIGR02869
929506002350	Putative peptidoglycan binding domain; Region: PG_binding_1; pfam01471
929506002351	Cell Wall Hydrolase; Region: Hydrolase_2; pfam07486
929506002352	serine O-acetyltransferase; Region: cysE; TIGR01172
929506002353	Serine acetyltransferase (SAT): SAT catalyzes the CoA-dependent acetylation of the side chain hydroxyl group of L-serine to form O-acetylserine, as the first step of a two-step biosynthetic pathway in bacteria and plants leading to the formation of...; Region: LbH_SAT; cd03354
929506002354	trimer interface [polypeptide binding]; other site
929506002355	active site
929506002356	substrate binding site [chemical binding]; other site
929506002357	CoA binding site [chemical binding]; other site
929506002358	Uncharacterized Fe-S protein [Energy production and conversion]; Region: COG1600
929506002359	Domain of unknown function (DUF1730); Region: DUF1730; pfam08331
929506002360	Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: AGPAT-like; Region: LPLAT_AGPAT-like; cd07989
929506002361	1-acyl-sn-glycerol-3-phosphate acyltransferase [Lipid metabolism]; Region: PlsC; COG0204
929506002362	putative acyl-acceptor binding pocket; other site
929506002363	Predicted EndoIII-related endonuclease [DNA replication, recombination, and repair]; Region: Nth; COG0177
929506002364	endonuclease III; includes endonuclease III (DNA-(apurinic or apyrimidinic site) lyase), alkylbase DNA glycosidases (Alka-family) and other DNA glycosidases; Region: ENDO3c; cd00056
929506002365	minor groove reading motif; other site
929506002366	helix-hairpin-helix signature motif; other site
929506002367	substrate binding pocket [chemical binding]; other site
929506002368	active site
929506002369	Iron-sulfur binding domain of endonuclease III; Region: EndIII_4Fe-2S; pfam10576
929506002370	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
929506002371	dimer interface [polypeptide binding]; other site
929506002372	phosphorylation site [posttranslational modification]
929506002373	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
929506002374	ATP binding site [chemical binding]; other site
929506002375	Mg2+ binding site [ion binding]; other site
929506002376	G-X-G motif; other site
929506002377	Response regulator receiver domain; Region: Response_reg; pfam00072
929506002378	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
929506002379	active site
929506002380	phosphorylation site [posttranslational modification]
929506002381	intermolecular recognition site; other site
929506002382	dimerization interface [polypeptide binding]; other site
929506002383	Cellulase M and related proteins [Carbohydrate transport and metabolism]; Region: FrvX; COG1363
929506002384	M42 Peptidase, Endoglucanase-like subfamily; Region: M42_glucanase_like; cd05657
929506002385	putative oligomer interface [polypeptide binding]; other site
929506002386	putative active site [active]
929506002387	metal binding site [ion binding]; metal-binding site
929506002388	Putative peptidoglycan binding domain; Region: PG_binding_4; pfam12229
929506002389	VanW like protein; Region: VanW; pfam04294
929506002390	G5 domain; Region: G5; pfam07501
929506002391	Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427
929506002392	haloacid dehalogenase-like hydrolase; Region: Hydrolase_3; pfam08282
929506002393	active site
929506002394	motif I; other site
929506002395	motif II; other site
929506002396	Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427
929506002397	haloacid dehalogenase-like hydrolase; Region: HAD; cl17202
929506002398	Predicted rRNA methylase (SpoU class) [Translation, ribosomal structure and biogenesis]; Region: CspR; COG0219
929506002399	EDD domain protein, DegV family; Region: DegV; TIGR00762
929506002400	Uncharacterized protein, DegV family COG1307; Region: DegV; pfam02645
929506002401	RNA polymerase factor sigma-54; Reviewed; Region: PRK05932
929506002402	Sigma-54 factor, Activator interacting domain (AID); Region: Sigma54_AID; pfam00309
929506002403	Sigma-54 factor, core binding domain; Region: Sigma54_CBD; pfam04963
929506002404	Sigma-54, DNA binding domain; Region: Sigma54_DBD; pfam04552
929506002405	Transcriptional regulator, contains sigma factor-related N-terminal domain [Transcription]; Region: DeoR; COG2390
929506002406	Putative sugar-binding domain; Region: Sugar-bind; pfam04198
929506002407	Glyceraldehyde-3-phosphate dehydrogenase/erythrose-4-phosphate dehydrogenase [Carbohydrate transport and metabolism]; Region: GapA; COG0057
929506002408	Glyceraldehyde 3-phosphate dehydrogenase, NAD binding domain; Region: Gp_dh_N; pfam00044
929506002409	Glyceraldehyde 3-phosphate dehydrogenase, C-terminal domain; Region: Gp_dh_C; pfam02800
929506002410	Uncharacterized ABC-type transport system, periplasmic component/surface lipoprotein [General function prediction only]; Region: Med; COG1744
929506002411	Periplasmic binding domain of basic membrane lipoprotein, PnrA, in Treponema pallidum and its homologs from other bacteria and Archaea; Region: PBP1_BmpA_PnrA_like; cd06354
929506002412	ligand binding site [chemical binding]; other site
929506002413	ABC-type uncharacterized transport systems, ATPase components [General function prediction only]; Region: COG3845
929506002414	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
929506002415	Walker A/P-loop; other site
929506002416	ATP binding site [chemical binding]; other site
929506002417	Q-loop/lid; other site
929506002418	ABC transporter signature motif; other site
929506002419	Walker B; other site
929506002420	D-loop; other site
929506002421	H-loop/switch region; other site
929506002422	Second domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_II; cd03215
929506002423	Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653
929506002424	Transmembrane subunit (TM) of Treponema pallidum (Tp) RbsC-1, RbsC-2 and related proteins. This is a functionally uncharacterized subgroup of TMs which belong to a larger group of TMs of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette; Region: TM_PBP1_transp_TpRbsC_like; cd06580
929506002425	TM-ABC transporter signature motif; other site
929506002426	Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653
929506002427	Transmembrane subunit (TM) of Treponema pallidum (Tp) RbsC-1, RbsC-2 and related proteins. This is a functionally uncharacterized subgroup of TMs which belong to a larger group of TMs of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette; Region: TM_PBP1_transp_TpRbsC_like; cd06580
929506002428	TM-ABC transporter signature motif; other site
929506002429	Phosphoglycerate kinase; Region: PGK; pfam00162
929506002430	Phosphoglycerate kinase (PGK) is a monomeric enzyme which catalyzes the transfer of the high-energy phosphate group of 1,3-bisphosphoglycerate to ADP, forming ATP and 3-phosphoglycerate. This reaction represents the first of the two substrate-level...; Region: Phosphoglycerate_kinase; cd00318
929506002431	substrate binding site [chemical binding]; other site
929506002432	hinge regions; other site
929506002433	ADP binding site [chemical binding]; other site
929506002434	catalytic site [active]
929506002435	triosephosphate isomerase; Provisional; Region: PRK14567
929506002436	Triosephosphate isomerase (TIM) is a glycolytic enzyme that catalyzes the interconversion of dihydroxyacetone phosphate and D-glyceraldehyde-3-phosphate. The reaction is very efficient and requires neither cofactors nor metal ions. TIM, usually...; Region: TIM; cd00311
929506002437	substrate binding site [chemical binding]; other site
929506002438	dimer interface [polypeptide binding]; other site
929506002439	catalytic triad [active]
929506002440	phosphoglyceromutase; Provisional; Region: PRK05434
929506002441	Phosphoglyceromutase [Carbohydrate transport and metabolism]; Region: GpmI; COG0696
929506002442	enolase; Provisional; Region: eno; PRK00077
929506002443	Enolase: Enolases are homodimeric enzymes that catalyse the reversible dehydration of 2-phospho-D-glycerate to phosphoenolpyruvate as part of the glycolytic and gluconeogenesis pathways. The reaction is facilitated by the presence of metal ions; Region: enolase; cd03313
929506002444	dimer interface [polypeptide binding]; other site
929506002445	metal binding site [ion binding]; metal-binding site
929506002446	substrate binding pocket [chemical binding]; other site
929506002447	Preprotein translocase SecG subunit; Region: SecG; pfam03840
929506002448	H(+) -translocating inorganic pyrophosphatase; Region: PLN02255; cl11452
929506002449	Inorganic H+ pyrophosphatase; Region: H_PPase; pfam03030
929506002450	ribonuclease R; Region: RNase_R; TIGR02063
929506002451	Ribonuclease B OB domain; Region: OB_RNB; pfam08206
929506002452	S1_like: Ribosomal protein S1-like RNA-binding domain. Found in a wide variety of RNA-associated proteins. Originally identified in S1 ribosomal protein. This superfamily also contains the Cold Shock Domain (CSD), which is a homolog of the S1 domain; Region: S1_like; cl09927
929506002453	RNB domain; Region: RNB; pfam00773
929506002454	S1_RNase_R: RNase R C-terminal S1 domain. RNase R is a processive 3' to 5' exoribonuclease, which is a homolog of RNase II. RNase R degrades RNA with secondary structure having a 3' overhang of at least 7 nucleotides. RNase R and PNPase...; Region: S1_RNase_R; cd04471
929506002455	RNA binding site [nucleotide binding]; other site
929506002456	Small protein B (SmpB) is a component of the trans-translation system in prokaryotes for releasing stalled ribosome from damaged messenger RNAs; Region: SmpB; cd09294
929506002457	SmpB-tmRNA interface; other site
929506002458	Integrase core domain; Region: rve; pfam00665
929506002459	Integrase core domain; Region: rve_2; pfam13333
929506002460	tRNA-dihydrouridine synthase [Translation, ribosomal structure and biogenesis]; Region: COG0042
929506002461	Dihydrouridine synthase-like (DUS-like) FMN-binding domain. Members of this family catalyze the reduction of the 5,6-double bond of a uridine residue on tRNA. Dihydrouridine modification of tRNA is widely observed in prokaryotes and eukaryotes, and also...; Region: DUS_like_FMN; cd02801
929506002462	FMN binding site [chemical binding]; other site
929506002463	active site
929506002464	catalytic residues [active]
929506002465	substrate binding site [chemical binding]; other site
929506002466	Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745
929506002467	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
929506002468	active site
929506002469	phosphorylation site [posttranslational modification]
929506002470	intermolecular recognition site; other site
929506002471	dimerization interface [polypeptide binding]; other site
929506002472	Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383
929506002473	DNA binding site [nucleotide binding]
929506002474	ABC-type multidrug transport system, ATPase component [Defense mechanisms]; Region: CcmA; COG1131
929506002475	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
929506002476	Walker A/P-loop; other site
929506002477	ATP binding site [chemical binding]; other site
929506002478	Q-loop/lid; other site
929506002479	ABC transporter signature motif; other site
929506002480	Walker B; other site
929506002481	D-loop; other site
929506002482	H-loop/switch region; other site
929506002483	ABC-type multidrug transport system, ATPase component [Defense mechanisms]; Region: CcmA; COG1131
929506002484	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
929506002485	Walker A/P-loop; other site
929506002486	ATP binding site [chemical binding]; other site
929506002487	Q-loop/lid; other site
929506002488	ABC transporter signature motif; other site
929506002489	Walker B; other site
929506002490	D-loop; other site
929506002491	H-loop/switch region; other site
929506002492	Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642
929506002493	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
929506002494	dimer interface [polypeptide binding]; other site
929506002495	phosphorylation site [posttranslational modification]
929506002496	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
929506002497	ATP binding site [chemical binding]; other site
929506002498	Mg2+ binding site [ion binding]; other site
929506002499	G-X-G motif; other site
929506002500	16S rRNA uridine-516 pseudouridylate synthase and related pseudouridylate synthases [Translation, ribosomal structure and biogenesis]; Region: RsuA; COG1187
929506002501	S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site;  Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cl09940
929506002502	RNA binding surface [nucleotide binding]; other site
929506002503	Pseudouridine synthase, Escherichia coli RluF like; Region: PseudoU_synth_RluF; cd02554
929506002504	probable active site [active]
929506002505	biotin biosynthesis protein BioC; Region: BioC; TIGR02072
929506002506	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
929506002507	S-adenosylmethionine binding site [chemical binding]; other site
929506002508	Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596
929506002509	pyridoxal phosphate-dependent acyltransferase, putative; Region: gly_Cac_T_rel; TIGR01825
929506002510	KBL_like; this family belongs to the pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD corresponds to serine palmitoyltransferase (SPT), 5-aminolevulinate synthase (ALAS); Region: KBL_like; cd06454
929506002511	substrate-cofactor binding pocket; other site
929506002512	pyridoxal 5'-phosphate binding site [chemical binding]; other site
929506002513	catalytic residue [active]
929506002514	Putative multicopper oxidases [Secondary metabolites biosynthesis, transport, and catabolism]; Region: SufI; COG2132
929506002515	Multicopper oxidase; Region: Cu-oxidase_3; pfam07732
929506002516	Multicopper oxidase; Region: Cu-oxidase; pfam00394
929506002517	Multicopper oxidase; Region: Cu-oxidase_2; pfam07731
929506002518	L-lactate dehydrogenase; Reviewed; Region: ldh; PRK00066
929506002519	L-2-hydroxyisocapronate dehydrogenases and some bacterial L-lactate dehydrogenases; Region: HicDH_like; cd05291
929506002520	tetramer (dimer of dimers) interface [polypeptide binding]; other site
929506002521	NAD binding site [chemical binding]; other site
929506002522	dimer interface [polypeptide binding]; other site
929506002523	substrate binding site [chemical binding]; other site
929506002524	Putative transcription activator [Transcription]; Region: TenA; COG0819
929506002525	Thiamine transporter protein (Thia_YuaJ); Region: Thia_YuaJ; cl17491
929506002526	Acetyltransferase (GNAT) domain; Region: Acetyltransf_3; pfam13302
929506002527	Acetyltransferase (GNAT) family; Region: Acetyltransf_1; pfam00583
929506002528	LigT like Phosphoesterase; Region: LigT_PEase; pfam02834
929506002529	2'-5' RNA ligase superfamily; Region: 2_5_RNA_ligase2; pfam13563
929506002530	PTS_IIA, PTS system, fructose/mannitol specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_fru; cd00211
929506002531	active site
929506002532	phosphorylation site [posttranslational modification]
929506002533	NEAr Transport domain, a component of cell surface proteins; Region: NEAT; cd06920
929506002534	heme-binding site [chemical binding]; other site
929506002535	NEAr Transport domain, a component of cell surface proteins; Region: NEAT; cd06920
929506002536	heme-binding site [chemical binding]; other site
929506002537	NEAr Transport domain, a component of cell surface proteins; Region: NEAT; cd06920
929506002538	heme-binding site [chemical binding]; other site
929506002539	NEAr Transport domain, a component of cell surface proteins; Region: NEAT; cd06920
929506002540	heme-binding site [chemical binding]; other site
929506002541	NEAr Transport domain, a component of cell surface proteins; Region: NEAT; cl02760
929506002542	NEAr Transport domain, a component of cell surface proteins; Region: NEAT; cd06920
929506002543	heme-binding site [chemical binding]; other site
929506002544	NEAr Transport domain, a component of cell surface proteins; Region: NEAT; cd06920
929506002545	heme-binding site [chemical binding]; other site
929506002546	NEAr Transport domain, a component of cell surface proteins; Region: NEAT; cd06920
929506002547	heme-binding site [chemical binding]; other site
929506002548	NEAr Transport domain, a component of cell surface proteins; Region: NEAT; cd06920
929506002549	heme-binding site [chemical binding]; other site
929506002550	heme ABC transporter, heme-binding protein isdE; Region: IsdE; TIGR03659
929506002551	Helical backbone metal receptor (TroA-like domain). These proteins have been shown to function in the ABC transport of ferric siderophores and metal ions such as Mn2+, Fe3+, Cu2+ and/or Zn2+.  Their ligand binding site is formed in the interface between...; Region: TroA-like; cl00262
929506002552	intersubunit interface [polypeptide binding]; other site
929506002553	iron-hydroxamate transporter permease subunit; Provisional; Region: PRK10577
929506002554	Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550
929506002555	ABC-ATPase subunit  interface; other site
929506002556	dimer interface [polypeptide binding]; other site
929506002557	putative PBP binding regions; other site
929506002558	ABC-type cobalamin/Fe3+-siderophores transport systems, ATPase components [Inorganic ion transport and metabolism / Coenzyme metabolism]; Region: FepC; COG1120
929506002559	ATP-binding component of iron-siderophores, vitamin B12 and hemin transporters and related proteins; Region: ABC_Iron-Siderophores_B12_Hemin; cd03214
929506002560	Walker A/P-loop; other site
929506002561	ATP binding site [chemical binding]; other site
929506002562	Q-loop/lid; other site
929506002563	ABC transporter signature motif; other site
929506002564	Walker B; other site
929506002565	D-loop; other site
929506002566	H-loop/switch region; other site
929506002567	Sortase D (SrtD) is a membrane transpeptidase found in gram-positive bacteria that anchors surface proteins to peptidoglycans of the bacterial cell wall envelope. This involves a transpeptidation reaction in which the surface protein substrate is cleaved...; Region: Sortase_D_5; cd06166
929506002568	active site
929506002569	catalytic site [active]
929506002570	ABC-type transport system involved in cytochrome bd biosynthesis, ATPase and permease components [Energy production and conversion / Posttranslational modification, protein turnover, chaperones]; Region: CydD; COG4988
929506002571	ABC transporter transmembrane region; Region: ABC_membrane; pfam00664
929506002572	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
929506002573	Walker A/P-loop; other site
929506002574	ATP binding site [chemical binding]; other site
929506002575	Q-loop/lid; other site
929506002576	ABC transporter signature motif; other site
929506002577	Walker B; other site
929506002578	D-loop; other site
929506002579	H-loop/switch region; other site
929506002580	ABC transporter transmembrane region; Region: ABC_membrane; pfam00664
929506002581	ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132
929506002582	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
929506002583	Walker A/P-loop; other site
929506002584	ATP binding site [chemical binding]; other site
929506002585	Q-loop/lid; other site
929506002586	ABC transporter signature motif; other site
929506002587	Walker B; other site
929506002588	D-loop; other site
929506002589	H-loop/switch region; other site
929506002590	PTS_IIB_ascorbate: subunit IIB of enzyme II (EII) of the L-ascorbate-specific phosphoenolpyruvate:carbohydrate phosphotransferase system (PTS). In this system, EII is an L-ascorbate-specific permease with two cytoplasmic subunits (IIA and IIB) and a...; Region: PTS_IIB_ascorbate; cd05563
929506002591	active site
929506002592	P-loop; other site
929506002593	phosphorylation site [posttranslational modification]
929506002594	molecular chaperone DnaK; Provisional; Region: dnaK; PRK00290
929506002595	Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cl17037
929506002596	nucleotide binding site [chemical binding]; other site
929506002597	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cl02429
929506002598	binding surface
929506002599	TPR motif; other site
929506002600	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
929506002601	TPR repeat; Region: TPR_11; pfam13414
929506002602	binding surface
929506002603	TPR motif; other site
929506002604	DnaJ domain or J-domain.  DnaJ/Hsp40 (heat shock protein 40) proteins are highly conserved and play crucial roles in protein translation, folding, unfolding, translocation, and degradation. They act primarily by stimulating the ATPase activity of Hsp70s; Region: DnaJ; cd06257
929506002605	HSP70 interaction site [polypeptide binding]; other site
929506002606	TPR repeat; Region: TPR_11; pfam13414
929506002607	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
929506002608	binding surface
929506002609	TPR motif; other site
929506002610	TPR repeat; Region: TPR_11; pfam13414
929506002611	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
929506002612	binding surface
929506002613	TPR motif; other site
929506002614	Winged helix-turn-helix DNA-binding; Region: HTH_24; pfam13412
929506002615	helix_turn_helix ASNC type; Region: HTH_ASNC; smart00344
929506002616	AsnC family; Region: AsnC_trans_reg; pfam01037
929506002617	hypothetical protein; Validated; Region: PRK07682
929506002618	Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609
929506002619	pyridoxal 5'-phosphate binding site [chemical binding]; other site
929506002620	homodimer interface [polypeptide binding]; other site
929506002621	catalytic residue [active]
929506002622	NEAr Transport domain, a component of cell surface proteins; Region: NEAT; cd06920
929506002623	heme-binding site [chemical binding]; other site
929506002624	NEAr Transport domain, a component of cell surface proteins; Region: NEAT; cd06920
929506002625	heme-binding site [chemical binding]; other site
929506002626	Leucine rich repeat; Region: LRR_8; pfam13855
929506002627	Leucine-rich repeats, outliers; Region: LRR; smart00370
929506002628	Leucine rich repeat; Region: LRR_8; pfam13855
929506002629	Leucine-rich repeats, outliers; Region: LRR; smart00370
929506002630	Leucine rich repeat; Region: LRR_8; pfam13855
929506002631	Leucine rich repeat; Region: LRR_8; pfam13855
929506002632	NEAr Transport domain, a component of cell surface proteins; Region: NEAT; cd06920
929506002633	heme-binding site [chemical binding]; other site
929506002634	Leucine rich repeat; Region: LRR_8; pfam13855
929506002635	Leucine rich repeat; Region: LRR_8; pfam13855
929506002636	Leucine rich repeat; Region: LRR_8; pfam13855
929506002637	NEAr Transport domain, a component of cell surface proteins; Region: NEAT; cl02760
929506002638	heme-binding site [chemical binding]; other site
929506002639	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
929506002640	binding surface
929506002641	TPR motif; other site
929506002642	Bacterial Ig-like domain; Region: Big_5; pfam13205
929506002643	Transcriptional regulators of sugar metabolism [Transcription / Carbohydrate transport and metabolism]; Region: GlpR; COG1349
929506002644	DeoR-like helix-turn-helix domain; Region: HTH_DeoR; pfam08220
929506002645	DeoR C terminal sensor domain; Region: DeoRC; pfam00455
929506002646	Predicted pyridoxal phosphate-dependent enzyme apparently involved in regulation of cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WecE; COG0399
929506002647	3-amino-5-hydroxybenzoic acid synthase family (AHBA_syn). AHBA_syn family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The members of this CD are involved in various biosynthetic pathways for secondary...; Region: AHBA_syn; cd00616
929506002648	inhibitor-cofactor binding pocket; inhibition site
929506002649	pyridoxal 5'-phosphate binding site [chemical binding]; other site
929506002650	catalytic residue [active]
929506002651	Predicted pyridoxal phosphate-dependent enzyme apparently involved in regulation of cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WecE; COG0399
929506002652	3-amino-5-hydroxybenzoic acid synthase family (AHBA_syn). AHBA_syn family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The members of this CD are involved in various biosynthetic pathways for secondary...; Region: AHBA_syn; cd00616
929506002653	inhibitor-cofactor binding pocket; inhibition site
929506002654	pyridoxal 5'-phosphate binding site [chemical binding]; other site
929506002655	catalytic residue [active]
929506002656	Malic enzyme, N-terminal domain; Region: malic; pfam00390
929506002657	NAD(P) binding domain of malic enzyme (ME), subgroup 2; Region: NAD_bind_2_malic_enz; cd05311
929506002658	putative NAD(P) binding site [chemical binding]; other site
929506002659	Na+/H+-dicarboxylate symporters [Energy production and conversion]; Region: GltP; COG1301
929506002660	Sodium:dicarboxylate symporter family; Region: SDF; pfam00375
929506002661	fumarate hydratase; Provisional; Region: PRK06246
929506002662	Fumarase C-terminus; Region: Fumerase_C; cl00795
929506002663	aspartate ammonia-lyase; Provisional; Region: aspA; PRK12273
929506002664	Aspartase; Region: Aspartase; cd01357
929506002665	active sites [active]
929506002666	tetramer interface [polypeptide binding]; other site
929506002667	DHHW protein; Region: DHHW; pfam14286
929506002668	DHHW protein; Region: DHHW; pfam14286
929506002669	Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745
929506002670	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
929506002671	active site
929506002672	phosphorylation site [posttranslational modification]
929506002673	intermolecular recognition site; other site
929506002674	dimerization interface [polypeptide binding]; other site
929506002675	Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383
929506002676	DNA binding site [nucleotide binding]
929506002677	Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642
929506002678	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
929506002679	dimer interface [polypeptide binding]; other site
929506002680	phosphorylation site [posttranslational modification]
929506002681	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
929506002682	ATP binding site [chemical binding]; other site
929506002683	Mg2+ binding site [ion binding]; other site
929506002684	G-X-G motif; other site
929506002685	BioY family; Region: BioY; pfam02632
929506002686	AAA domain; Region: AAA_26; pfam13500
929506002687	dithiobiotin synthetase; Reviewed; Region: bioD; PRK00090
929506002688	Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610
929506002689	adenosylmethionine-8-amino-7-oxononanoate transaminase; Region: bioA; TIGR00508
929506002690	inhibitor-cofactor binding pocket; inhibition site
929506002691	pyridoxal 5'-phosphate binding site [chemical binding]; other site
929506002692	catalytic residue [active]
929506002693	biotin synthase; Region: bioB; TIGR00433
929506002694	Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335
929506002695	FeS/SAM binding site; other site
929506002696	Biotin and Thiamin Synthesis associated domain; Region: BATS; pfam06968
929506002697	Creatinase/Prolidase N-terminal domain; Region: Creatinase_N; pfam01321
929506002698	Xaa-Pro aminopeptidase [Amino acid transport and metabolism]; Region: PepP; COG0006
929506002699	Creatinase/Prolidase N-terminal domain; Region: Creatinase_N; pfam01321
929506002700	X-Prolyl Aminopeptidase 2. E.C. 3.4.11.9. Also known as X-Pro aminopeptidase, proline aminopeptidase, aminopeptidase P, and aminoacylproline aminopeptidase. Catalyses release of any N-terminal amino acid, including proline, that is linked with proline; Region: APP; cd01085
929506002701	active site
929506002702	hypothetical protein; Provisional; Region: PRK10410
929506002703	Thiol-activated cytolysin; Region: Thiol_cytolysin; pfam01289
929506002704	helicase 45; Provisional; Region: PTZ00424
929506002705	DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cl17251
929506002706	ATP binding site [chemical binding]; other site
929506002707	putative Mg++ binding site [ion binding]; other site
929506002708	Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079
929506002709	nucleotide binding region [chemical binding]; other site
929506002710	ATP-binding site [chemical binding]; other site
929506002711	ATP-dependent RNA helicase DbpA; Provisional; Region: PRK11776
929506002712	DEAD-box helicases. A diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker  B motif; Region: DEADc; cd00268
929506002713	ATP binding site [chemical binding]; other site
929506002714	Mg++ binding site [ion binding]; other site
929506002715	motif III; other site
929506002716	Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079
929506002717	nucleotide binding region [chemical binding]; other site
929506002718	ATP-binding site [chemical binding]; other site
929506002719	RNA recognition motif in Bacillus subtilis ATP-dependent RNA helicase YxiN and similar proteins; Region: RRM_BsYxiN_like; cd12500
929506002720	RNA binding site [nucleotide binding]; other site
929506002721	6-phosphogluconolactonase/Glucosamine-6-phosphate isomerase/deaminase [Carbohydrate transport and metabolism]; Region: NagB; COG0363
929506002722	GlcN6P_deaminase: Glucosamine-6-phosphate (GlcN6P) deaminase subfamily; GlcN6P deaminase catalyzes the reversible conversion of GlcN6P to D-fructose-6-phosphate (Fru6P) and ammonium. The reaction is an aldo-keto isomerization coupled with an amination or...; Region: GlcN6P_deaminase; cd01399
929506002723	active site
929506002724	trimer interface [polypeptide binding]; other site
929506002725	allosteric site; other site
929506002726	active site lid [active]
929506002727	hexamer (dimer of trimers) interface [polypeptide binding]; other site
929506002728	N-acetylglucosamine-6-phosphate deacetylase, NagA, catalyzes the hydrolysis of the N-acetyl group of N-acetyl-glucosamine-6-phosphate (GlcNAc-6-P) to glucosamine 6-phosphate and acetate. This is the first committed step in the biosynthetic pathway to...; Region: NagA; cd00854
929506002729	N-acetylglucosamine-6-phosphate deacetylase [Carbohydrate transport and metabolism]; Region: NagA; COG1820
929506002730	active site
929506002731	dimer interface [polypeptide binding]; other site
929506002732	Transcriptional regulators [Transcription]; Region: PhnF; COG2188
929506002733	Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377
929506002734	DNA-binding site [nucleotide binding]; DNA binding site
929506002735	UTRA domain; Region: UTRA; pfam07702
929506002736	uncharacterized subgroup of the Na(+)/iodide (NIS) cotransporter subfamily; putative solute-binding domain; Region: SLC5sbd_NIS-like_u3; cd11495
929506002737	Na binding site [ion binding]; other site
929506002738	Transcriptional regulators [Transcription]; Region: PurR; COG1609
929506002739	Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392
929506002740	DNA binding site [nucleotide binding]
929506002741	domain linker motif; other site
929506002742	Periplasmic sugar-binding domain of active transport systems that are members of the type I periplasmic binding protein (PBP1) superfamily; Region: PBP1_ABC_sugar_binding_like; cd01536
929506002743	ligand binding site [chemical binding]; other site
929506002744	N-acetylneuraminate lyase; Provisional; Region: PRK04147
929506002745	N-Acetylneuraminic acid aldolase, also called N-acetylneuraminate lyase (NAL); Region: NAL; cd00954
929506002746	inhibitor site; inhibition site
929506002747	active site
929506002748	dimer interface [polypeptide binding]; other site
929506002749	catalytic residue [active]
929506002750	N-acetylmannosamine-6-phosphate epimerase (NanE) converts N-acetylmannosamine-6-phosphate to N-acetylglucosamine-6-phosphate. This reaction is part of the pathway that allows the usage of sialic acid as a carbohydrate source. Sialic acids are a family of...; Region: NanE; cd04729
929506002751	N-acetylmannosamine-6-phosphate 2-epimerase; Provisional; Region: PRK01130
929506002752	putative active site cavity [active]
929506002753	Domain of unknown function (DUF386); Region: DUF386; cl01047
929506002754	Transcriptional regulator/sugar kinase [Transcription / Carbohydrate transport and metabolism]; Region: NagC; COG1940
929506002755	Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cd00012
929506002756	nucleotide binding site [chemical binding]; other site
929506002757	putative iron-only hydrogenase system regulator; Region: hyd_TM1266; TIGR03959
929506002758	[FeFe] hydrogenase H-cluster radical SAM maturase HydE; Region: rSAM_HydE; TIGR03956
929506002759	Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335
929506002760	FeS/SAM binding site; other site
929506002761	Biotin and Thiamin Synthesis associated domain; Region: BATS; smart00876
929506002762	thiamine biosynthesis protein ThiH; Reviewed; Region: thiH; PRK09613
929506002763	Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335
929506002764	FeS/SAM binding site; other site
929506002765	Biotin and Thiamin Synthesis associated domain; Region: BATS; smart00876
929506002766	[FeFe] hydrogenase H-cluster maturation GTPase HydF; Region: GTP_HydF; TIGR03918
929506002767	E. coli Ras-like protein (Era)-like GTPase; Region: Era_like; cd00880
929506002768	G1 box; other site
929506002769	GTP/Mg2+ binding site [chemical binding]; other site
929506002770	Switch I region; other site
929506002771	G2 box; other site
929506002772	Switch II region; other site
929506002773	G3 box; other site
929506002774	G4 box; other site
929506002775	G5 box; other site
929506002776	This uncharacterized conserved protein belongs to a family of iron-molybdenum cluster-binding proteins that includes NifX, NifB, and NifY, all of which are involved in the synthesis of an iron-molybdenum cofactor (FeMo-co) that binds the active site of...; Region: MTH1175; cd00851
929506002777	MinD superfamily P-loop ATPase containing an inserted ferredoxin domain [Energy production and conversion]; Region: COG1149
929506002778	This protein family's function is unkown. It contains nucleotide binding site. It uses NTP as energy source to transfer electron or ion; Region: Fer4_NifH_child; cd03110
929506002779	P loop nucleotide binding; other site
929506002780	switch II; other site
929506002781	This protein family's function is unkown. It contains nucleotide binding site. It uses NTP as energy source to transfer electron or ion; Region: Fer4_NifH_child; cd03110
929506002782	P loop nucleotide binding; other site
929506002783	4Fe-4S dicluster domain; Region: Fer4_9; pfam13187
929506002784	CobQ/CobB/MinD/ParA nucleotide binding domain; Region: CbiA; pfam01656
929506002785	switch II; other site
929506002786	This uncharacterized conserved protein belongs to a family of iron-molybdenum cluster-binding proteins that includes NifX, NifB, and NifY, all of which are involved in the synthesis of an iron-molybdenum cofactor (FeMo-co) that binds the active site of...; Region: MTH1175; cd00851
929506002787	Predicted DNA-binding proteins [General function prediction only]; Region: COG1342
929506002788	DNA binding residues [nucleotide binding]
929506002789	RNA polymerase sigma factor, sigma-70 family; Region: sigma70-ECF; TIGR02937
929506002790	Catalytic NodB homology domain of Bacillus subtilis polysaccharide deacetylase PdaA, and its bacterial homologs; Region: CE4_BsPdaA_like; cd10948
929506002791	delta-lactam-biosynthetic de-N-acetylase; Region: spore_pdaA; TIGR02884
929506002792	NodB motif; other site
929506002793	active site
929506002794	catalytic site [active]
929506002795	Cd binding site [ion binding]; other site
929506002796	Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118
929506002797	Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118
929506002798	Cell Wall Hydrolase; Region: Hydrolase_2; pfam07486
929506002799	Transcriptional regulators [Transcription]; Region: PurR; COG1609
929506002800	Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392
929506002801	DNA binding site [nucleotide binding]
929506002802	domain linker motif; other site
929506002803	Ligand binding domain of the LacI tanscriptional regulator family belonging to the type I periplasmic-binding fold protein superfamily; Region: PBP1_LacI_sugar_binding_like; cd06267
929506002804	dimerization interface [polypeptide binding]; other site
929506002805	ligand binding site [chemical binding]; other site
929506002806	2-deoxyribose-5-phosphate aldolase (DERA) of the DeoC family; Region: DeoC; cd00959
929506002807	intersubunit interface [polypeptide binding]; other site
929506002808	active site
929506002809	catalytic residue [active]
929506002810	phosphopentomutase; Provisional; Region: PRK05362
929506002811	Metalloenzyme superfamily; Region: Metalloenzyme; pfam01676
929506002812	purine nucleoside phosphorylase; Provisional; Region: PRK08202
929506002813	pyrimidine-nucleoside phosphorylase; Reviewed; Region: PRK06078
929506002814	Glycosyl transferase family, helical bundle domain; Region: Glycos_trans_3N; pfam02885
929506002815	Glycosyl transferase family, a/b domain; Region: Glycos_transf_3; pfam00591
929506002816	Pyrimidine nucleoside phosphorylase C-terminal domain; Region: PYNP_C; smart00941
929506002817	Nucleoside permease [Nucleotide transport and metabolism]; Region: NupC; COG1972
929506002818	Na+ dependent nucleoside transporter N-terminus; Region: Nucleos_tra2_N; pfam01773
929506002819	Nucleoside recognition; Region: Gate; pfam07670
929506002820	Na+ dependent nucleoside transporter C-terminus; Region: Nucleos_tra2_C; pfam07662
929506002821	HAD superfamily, subfamily IIIB (Acid phosphatase); Region: Acid_phosphat_B; cl17236
929506002822	Domain of unknown function (DUF4356); Region: DUF4356; pfam14266
929506002823	thiamine biosynthesis protein ThiS; Region: thiS; TIGR01683
929506002824	charged pocket; other site
929506002825	hydrophobic patch; other site
929506002826	thiamine biosynthesis protein ThiF; Provisional; Region: PRK08644
929506002827	E1_ThiF_like. Member of superfamily of activating enzymes (E1) of the ubiquitin-like proteins. The common reaction mechanism catalyzed by E1-like enzymes begins with a nucleophilic attack of the C-terminal carboxylate of the ubiquitin-like substrate, on...; Region: E1_ThiF_like; cd01487
929506002828	putative ATP binding site [chemical binding]; other site
929506002829	putative substrate interface [chemical binding]; other site
929506002830	Thiazole synthase (ThiG) is the tetrameric enzyme that is involved in the formation of the thiazole moiety of thiamin pyrophosphate, an essential ubiquitous cofactor that plays an important role in carbohydrate and amino acid metabolism. ThiG catalyzes...; Region: ThiG; cd04728
929506002831	ThiS interaction site; other site
929506002832	putative active site [active]
929506002833	tetramer interface [polypeptide binding]; other site
929506002834	thiamine biosynthesis protein ThiH; Reviewed; Region: thiH; PRK09240
929506002835	Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335
929506002836	FeS/SAM binding site; other site
929506002837	Biotin and Thiamin Synthesis associated domain; Region: BATS; smart00876
929506002838	Thiamine monophosphate synthase (TMP synthase)/TenI. TMP synthase catalyzes an important step in the thiamine biosynthesis pathway, the substitution of the pyrophosphate of 2-methyl-4-amino-5- hydroxymethylpyrimidine pyrophosphate by 4-methyl-5-; Region: TMP_TenI; cd00564
929506002839	thiamine phosphate binding site [chemical binding]; other site
929506002840	active site
929506002841	pyrophosphate binding site [ion binding]; other site
929506002842	Predicted xylanase/chitin deacetylase [Carbohydrate transport and metabolism]; Region: CDA1; COG0726
929506002843	Catalytic NodB homology domain of Streptococcus mutans polysaccharide deacetylase PgdA, Bacillus subtilis YheN, and similar proteins; Region: CE4_SmPgdA_like; cd10944
929506002844	NodB motif; other site
929506002845	active site
929506002846	catalytic site [active]
929506002847	Zn binding site [ion binding]; other site
929506002848	Putative amidase domain; Region: Amidase_6; pfam12671
929506002849	Subfamily of the multidrug and toxic compound extrusion (MATE)-like proteins similar to Thermotoga marina NorM; Region: MATE_NorM_like; cd13137
929506002850	putative efflux protein, MATE family; Region: matE; TIGR00797
929506002851	Predicted integral membrane protein [Function unknown]; Region: COG0392
929506002852	Uncharacterized conserved protein [Function unknown]; Region: COG2898
929506002853	Uncharacterized conserved protein (DUF2156); Region: DUF2156; pfam09924
929506002854	Predicted HD-superfamily hydrolase [General function prediction only]; Region: COG3481
929506002855	Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077
929506002856	Zn2+ binding site [ion binding]; other site
929506002857	Mg2+ binding site [ion binding]; other site
929506002858	Hemolysins and related proteins containing CBS domains [General function prediction only]; Region: TlyC; COG1253
929506002859	Domain of unknown function DUF21; Region: DUF21; pfam01595
929506002860	This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains associated with the CorC_HlyC domain. CorC_HlyC is a transporter associated domain. This small domain is found in Na+/H+ antiporters, in proteins involved in...; Region: CBS_pair_CorC_HlyC_assoc; cd04590
929506002861	Transporter associated domain; Region: CorC_HlyC; smart01091
929506002862	Putative Mg2+ and Co2+ transporter CorB [Inorganic ion transport and metabolism]; Region: CorB; COG4536
929506002863	Domain of unknown function DUF21; Region: DUF21; pfam01595
929506002864	This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains associated with the CorC_HlyC domain. CorC_HlyC is a transporter associated domain. This small domain is found in Na+/H+ antiporters, in proteins involved in...; Region: CBS_pair_CorC_HlyC_assoc; cd04590
929506002865	Transporter associated domain; Region: CorC_HlyC; smart01091
929506002866	Predicted glycosyl hydrolase [General function prediction only]; Region: COG3858
929506002867	Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118
929506002868	Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118
929506002869	Cortical fragment-lytic enzyme (CFLE) is a peptidoglycan hydrolase involved in  bacterial endospore germination.  CFLE is expressed as an inactive preprotein (called SleB) in the forespore compartment of sporulating cells.  SleB translocates across the...; Region: GH18_CFLE_spore_hydrolase; cd02874
929506002870	active site
929506002871	Firmicute fructose-1,6-bisphosphatase; Region: FBPase_2; pfam06874
929506002872	Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745
929506002873	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
929506002874	active site
929506002875	phosphorylation site [posttranslational modification]
929506002876	intermolecular recognition site; other site
929506002877	dimerization interface [polypeptide binding]; other site
929506002878	Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383
929506002879	DNA binding site [nucleotide binding]
929506002880	Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642
929506002881	Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225
929506002882	dimerization interface [polypeptide binding]; other site
929506002883	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
929506002884	dimer interface [polypeptide binding]; other site
929506002885	phosphorylation site [posttranslational modification]
929506002886	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
929506002887	ATP binding site [chemical binding]; other site
929506002888	Mg2+ binding site [ion binding]; other site
929506002889	G-X-G motif; other site
929506002890	periplasmic serine pepetdase DegS; Region: protease_degS; TIGR02038
929506002891	Trypsin-like peptidase domain; Region: Trypsin_2; pfam13365
929506002892	PDZ domain of tryspin-like serine proteases, such as DegP/HtrA, which are oligomeric proteins involved in heat-shock response, chaperone function, and apoptosis. May be responsible for substrate recognition and/or binding, as most PDZ domains bind...; Region: PDZ_serine_protease; cd00987
929506002893	protein binding site [polypeptide binding]; other site
929506002894	Virulence factor BrkB; Region: Virul_fac_BrkB; pfam03631
929506002895	Transposase domain (DUF772); Region: DUF772; pfam05598
929506002896	Transposase DDE domain; Region: DDE_Tnp_1_6; pfam13751
929506002897	Transglutaminase-like superfamily; Region: Transglut_core; pfam01841
929506002898	Uncharacterized oxidoreductases, Fe-dependent alcohol dehydrogenase family [Energy production and conversion]; Region: COG1979
929506002899	Butanol dehydrogenase catalyzes the conversion of butyraldehyde to butanol with the cofactor NAD(P)H being oxidized in the process; Region: BDH; cd08187
929506002900	dimer interface [polypeptide binding]; other site
929506002901	active site
929506002902	metal binding site [ion binding]; metal-binding site
929506002903	Na+/H+-dicarboxylate symporters [Energy production and conversion]; Region: GltP; COG1301
929506002904	Sodium:dicarboxylate symporter family; Region: SDF; pfam00375
929506002905	MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704
929506002906	ABC-type transport system, involved in lipoprotein release, permease component [Cell envelope biogenesis, outer membrane]; Region: LolE; COG4591
929506002907	FtsX-like permease family; Region: FtsX; pfam02687
929506002908	ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136
929506002909	ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255
929506002910	Walker A/P-loop; other site
929506002911	ATP binding site [chemical binding]; other site
929506002912	Q-loop/lid; other site
929506002913	ABC transporter signature motif; other site
929506002914	Walker B; other site
929506002915	D-loop; other site
929506002916	H-loop/switch region; other site
929506002917	DDE domain; Region: DDE_Tnp_IS240; pfam13610
929506002918	Integrase core domain; Region: rve; pfam00665
929506002919	Integrase core domain; Region: rve_3; pfam13683
929506002920	Chain length determinant protein; Region: Wzz; cl15801
929506002921	Capsular polysaccharide biosynthesis protein [Cell envelope biogenesis, outer membrane]; Region: COG3944
929506002922	capsular exopolysaccharide family; Region: eps_fam; TIGR01007
929506002923	The Fer4_NifH superfamily contains a variety of proteins which share a common ATP-binding domain. Functionally, proteins in this superfamily use the energy from hydrolysis of NTP to transfer electron or ion; Region: Fer4_NifH; cl17203
929506002924	Capsular polysaccharide biosynthesis protein [Carbohydrate transport and metabolism / Cell envelope biogenesis, outer membrane]; Region: CapC; COG4464
929506002925	LicD family; Region: LicD; cl01378
929506002926	LicD family; Region: LicD; cl01378
929506002927	CDP-ME synthetase is involved in mevalonate-independent isoprenoid production; Region: CDP-ME_synthetase; cd02516
929506002928	substrate binding site; other site
929506002929	dimer interface; other site
929506002930	Medium chain reductase/dehydrogenase (MDR)/zinc-dependent alcohol dehydrogenase-like family; Region: MDR; cl16912
929506002931	Threonine dehydrogenase and related Zn-dependent dehydrogenases [Amino acid transport and metabolism / General function prediction only]; Region: Tdh; COG1063
929506002932	NAD(P) binding site [chemical binding]; other site
929506002933	Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438
929506002934	This family is most closely related to the GT1 family of glycosyltransferases. AmSD in Erwinia amylovora has been shown to be involved in the biosynthesis of amylovoran, the acidic exopolysaccharide acting as a virulence factor. This enzyme may be...; Region: GT1_amsD_like; cd03820
929506002935	putative ADP-binding pocket [chemical binding]; other site
929506002936	Lipid A core - O-antigen ligase and related enzymes [Cell envelope biogenesis, outer membrane]; Region: RfaL; COG3307
929506002937	O-Antigen ligase; Region: Wzy_C; pfam04932
929506002938	TupA-like ATPgrasp; Region: ATPgrasp_TupA; pfam14305
929506002939	CapA and related proteins, metallophosphatase domain; Region: MPP_CapA; cd07381
929506002940	putative active site [active]
929506002941	putative metal binding site [ion binding]; other site
929506002942	Bacterial capsule synthesis protein PGA_cap; Region: PGA_cap; smart00854
929506002943	colanic acid exporter; Provisional; Region: PRK10459
929506002944	Uncharacterized subfamily of the multidrug and toxic compound extrusion (MATE) proteins; Region: MATE_tuaB_like; cd13127
929506002945	Acyltransferase family; Region: Acyl_transf_3; pfam01757
929506002946	Predicted UDP-glucose 6-dehydrogenase [Cell envelope biogenesis, outer membrane]; Region: Ugd; COG1004
929506002947	3-hydroxyacyl-CoA dehydrogenase, NAD binding domain; Region: 3HCDH_N; pfam02737
929506002948	UDP-glucose/GDP-mannose dehydrogenase family, central domain; Region: UDPG_MGDP_dh; pfam00984
929506002949	UDP binding domain; Region: UDPG_MGDP_dh_C; smart00984
929506002950	Nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: WcaG; COG0451
929506002951	UDP glucuronic acid epimerase, extended (e) SDRs; Region: UDP_GE_SDE_e; cd05253
929506002952	putative NAD(P) binding site [chemical binding]; other site
929506002953	active site
929506002954	putative substrate binding site [chemical binding]; other site
929506002955	Predicted integral membrane protein [Function unknown]; Region: COG5652
929506002956	glucose-1-phosphate thymidylyltransferase RfbA; Provisional; Region: PRK15480
929506002957	Prokaryotic UGPase catalyses the synthesis of UDP-glucose; Region: UGPase_prokaryotic; cd02541
929506002958	active site
929506002959	tetramer interface; other site
929506002960	Transglutaminase-like superfamily; Region: Transglut_core; pfam01841
929506002961	Four helix bundle sensory module for signal transduction; Region: 4HB_MCP_1; pfam12729
929506002962	Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225
929506002963	dimerization interface [polypeptide binding]; other site
929506002964	Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386
929506002965	dimer interface [polypeptide binding]; other site
929506002966	Methyl-accepting chemotaxis protein (MCP) signalling domain; Region: MCPsignal; pfam00015
929506002967	putative CheW interface [polypeptide binding]; other site
929506002968	Transcriptional regulator [Transcription]; Region: AcrR; COG1309
929506002969	Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440
929506002970	Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533
929506002971	HlyD family secretion protein; Region: HlyD_3; pfam13437
929506002972	putative membrane fusion protein; Region: TIGR02828
929506002973	Cation/multidrug efflux pump [Defense mechanisms]; Region: AcrB; COG0841
929506002974	Outer membrane protein [Cell envelope biogenesis, outer membrane / Intracellular trafficking and secretion]; Region: TolC; COG1538
929506002975	Outer membrane efflux protein; Region: OEP; pfam02321
929506002976	RND family efflux transporter, MFP subunit; Region: RND_mfp; TIGR01730
929506002977	HlyD family secretion protein; Region: HlyD_3; pfam13437
929506002978	Periplasmic binding protein domain; Region: Peripla_BP_4; pfam13407
929506002979	Periplasmic sugar-binding domain of active transport systems that are members of the type I periplasmic binding protein (PBP1) superfamily; Region: PBP1_ABC_sugar_binding_like; cd01536
929506002980	ligand binding site [chemical binding]; other site
929506002981	Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer); Region: MA; smart00283
929506002982	Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386
929506002983	dimer interface [polypeptide binding]; other site
929506002984	putative CheW interface [polypeptide binding]; other site
929506002985	Predicted membrane protein [Function unknown]; Region: COG1971
929506002986	Domain of unknown function DUF; Region: DUF204; pfam02659
929506002987	Single-stranded DNA-binding protein [DNA replication, recombination, and repair]; Region: Ssb; COG0629
929506002988	SSB_OBF: A subfamily of OB folds similar to the OB fold of ssDNA-binding protein (SSB). SSBs bind with high affinity to ssDNA. They bind to and protect ssDNA intermediates during DNA metabolic pathways. All bacterial and eukaryotic SSBs studied to date...; Region: SSB_OBF; cd04496
929506002989	dimer interface [polypeptide binding]; other site
929506002990	ssDNA binding site [nucleotide binding]; other site
929506002991	tetramer (dimer of dimers) interface [polypeptide binding]; other site
929506002992	Ferric uptake regulator(Fur) and related metalloregulatory proteins; typically iron-dependent, DNA-binding repressors and activators; Region: Fur_like; cd07153
929506002993	metal binding site 2 [ion binding]; metal-binding site
929506002994	putative DNA binding helix; other site
929506002995	metal binding site 1 [ion binding]; metal-binding site
929506002996	dimer interface [polypeptide binding]; other site
929506002997	structural Zn2+ binding site [ion binding]; other site
929506002998	oligoendopeptidase F; Region: pepF; TIGR00181
929506002999	Peptidase family M3B Oligopeptidase F (PepF); Region: M3B_PepF_3; cd09608
929506003000	active site
929506003001	Zn binding site [ion binding]; other site
929506003002	c-di-GMP phosphodiesterase class II (HD-GYP domain) [Signal transduction mechanisms]; Region: COG2206
929506003003	Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077
929506003004	Zn2+ binding site [ion binding]; other site
929506003005	Mg2+ binding site [ion binding]; other site
929506003006	Rhomboid family; Region: Rhomboid; pfam01694
929506003007	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cl17736
929506003008	active site
929506003009	dimerization interface [polypeptide binding]; other site
929506003010	ATP-dependent metalloprotease FtsH; Region: FtsH_fam; TIGR01241
929506003011	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
929506003012	Walker A motif; other site
929506003013	ATP binding site [chemical binding]; other site
929506003014	Walker B motif; other site
929506003015	arginine finger; other site
929506003016	Peptidase family M41; Region: Peptidase_M41; pfam01434
929506003017	Uncharacterized conserved protein [Function unknown]; Region: COG3339
929506003018	RNase H is an endonuclease that cleaves the RNA strand of an RNA/DNA hybrid in a sequence non-specific manner; Region: RNase_H; cl14782
929506003019	RNA/DNA hybrid binding site [nucleotide binding]; other site
929506003020	active site
929506003021	YtxH-like protein; Region: YtxH; pfam12732
929506003022	Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093
929506003023	non-specific DNA binding site [nucleotide binding]; other site
929506003024	salt bridge; other site
929506003025	sequence-specific DNA binding site [nucleotide binding]; other site
929506003026	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cl02429
929506003027	binding surface
929506003028	TPR motif; other site
929506003029	Tetratricopeptide repeat; Region: TPR_12; pfam13424
929506003030	Tetratricopeptide repeat; Region: TPR_12; pfam13424
929506003031	Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093
929506003032	non-specific DNA binding site [nucleotide binding]; other site
929506003033	salt bridge; other site
929506003034	sequence-specific DNA binding site [nucleotide binding]; other site
929506003035	Type 1 glutamine amidotransferase (GATase1) domain found in Cobyric Acid Synthase (CobQ); Region: GATase1_CobQ; cd01750
929506003036	catalytic triad [active]
929506003037	UDP-N-acetylmuramyl tripeptide synthase [Cell envelope biogenesis, outer membrane]; Region: MurE; COG0769
929506003038	Mur ligase middle domain; Region: Mur_ligase_M; pfam08245
929506003039	Domain of unknown function (DUF1727); Region: DUF1727; pfam08353
929506003040	Bacterial capsule synthesis protein PGA_cap; Region: PGA_cap; smart00854
929506003041	CapA and related proteins, metallophosphatase domain; Region: MPP_CapA; cd07381
929506003042	putative active site [active]
929506003043	putative metal binding site [ion binding]; other site
929506003044	Uncharacterized conserved protein [Function unknown]; Region: COG1434
929506003045	YdcF-like. YdcF-like is a large family of mainly bacterial proteins, with a few members found in fungi, plants, and archaea. Escherichia coli YdcF has been shown to bind S-adenosyl-L-methionine (AdoMet), but a biochemical function has not been...; Region: YdcF-like; cd06259
929506003046	putative active site [active]
929506003047	Uncharacterized conserved protein [Function unknown]; Region: COG1284
929506003048	Uncharacterized BCR, YitT family COG1284; Region: DUF161; pfam02588
929506003049	Uncharacterized protein conserved in bacteria (DUF2179); Region: DUF2179; pfam10035
929506003050	electron transport complex, RnfABCDGE type, C subunit; Region: rnfC; TIGR01945
929506003051	SLBB domain; Region: SLBB; pfam10531
929506003052	4Fe-4S binding domain; Region: Fer4; pfam00037
929506003053	NQR2, RnfD, RnfE family; Region: NQR2_RnfD_RnfE; pfam03116
929506003054	FMN-binding domain; Region: FMN_bind; cl01081
929506003055	electron transport complex RsxE subunit; Provisional; Region: PRK12405
929506003056	electron transport complex, RnfABCDGE type, A subunit; Region: rnfA; TIGR01943
929506003057	4Fe-4S dicluster domain; Region: Fer4_7; pfam12838
929506003058	RPB11 and RPB3 subunits of RNA polymerase; Region: RNAP_RPB11_RPB3; cl11409
929506003059	4Fe-4S dicluster domain; Region: Fer4_7; pfam12838
929506003060	RPB11 and RPB3 subunits of RNA polymerase; Region: RNAP_RPB11_RPB3; cl11409
929506003061	4Fe-4S dicluster domain; Region: Fer4_7; pfam12838
929506003062	Mg/Co/Ni transporter MgtE (contains CBS domain) [Inorganic ion transport and metabolism]; Region: MgtE; COG2239
929506003063	MgtE intracellular N domain; Region: MgtE_N; smart00924
929506003064	This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domain in the magnesium transporter, MgtE.  MgtE and its homologs are found in eubacteria, archaebacteria, and eukaryota. Members of this family transport Mg2+ or other...; Region: CBS_pair_Mg_transporter; cd04606
929506003065	Divalent cation transporter; Region: MgtE; pfam01769
929506003066	Four helix bundle sensory module for signal transduction; Region: 4HB_MCP_1; pfam12729
929506003067	Methyl-accepting chemotaxis protein [Cell motility and secretion / Signal transduction mechanisms]; Region: Tar; COG0840
929506003068	Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cl01054
929506003069	Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386
929506003070	dimer interface [polypeptide binding]; other site
929506003071	putative CheW interface [polypeptide binding]; other site
929506003072	Uncharacterized ACR, YkgG family COG1556; Region: DUF162; pfam02589
929506003073	5-keto-4-deoxyuronate isomerase; Provisional; Region: PRK00924
929506003074	2-deoxy-D-gluconate 3-dehydrogenase; Provisional; Region: PRK06935
929506003075	gluconate 5-dehydrogenase (Ga5DH)-like, classical (c) SDRs; Region: Ga5DH-like_SDR_c; cd05347
929506003076	NADP binding site [chemical binding]; other site
929506003077	homodimer interface [polypeptide binding]; other site
929506003078	active site
929506003079	2-keto-3-deoxy-6-phosphogluconate aldolase [Carbohydrate transport and metabolism]; Region: Eda; COG0800
929506003080	KDPG and KHG aldolase; Region: KDPG_aldolase; cd00452
929506003081	active site
929506003082	intersubunit interface [polypeptide binding]; other site
929506003083	catalytic residue [active]
929506003084	Sugar kinases, ribokinase family [Carbohydrate transport and metabolism]; Region: RbsK; COG0524
929506003085	2-keto-3-deoxygluconate kinase (KdgK) phosphorylates 2-keto-3-deoxygluconate (KDG) to form 2-keto-3-deoxy-6-phosphogluconate (KDGP). KDG is the common intermediate product, that allows organisms to channel D-glucuronate and/or D-galacturinate into the...; Region: KdgK; cd01166
929506003086	substrate binding site [chemical binding]; other site
929506003087	ATP binding site [chemical binding]; other site
929506003088	Glycosyl Hydrolase Family 88; Region: Glyco_hydro_88; pfam07470
929506003089	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3677
929506003090	InsA N-terminal domain; Region: Zn_Tnp_IS1; pfam03811
929506003091	DDE domain; Region: DDE_Tnp_IS240; pfam13610
929506003092	Integrase core domain; Region: rve; pfam00665
929506003093	Integrase core domain; Region: rve_3; pfam13683
929506003094	Glycosyl Hydrolase Family 88; Region: Glyco_hydro_88; pfam07470
929506003095	PTS system sorbose-specific iic component; Region: EII-Sor; pfam03609
929506003096	PTS system mannose/fructose/sorbose family IID component; Region: EIID-AGA; pfam03613
929506003097	Preprotein translocase subunit; Region: YajC; pfam02699
929506003098	Transcriptional regulators [Transcription]; Region: PurR; COG1609
929506003099	Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392
929506003100	DNA binding site [nucleotide binding]
929506003101	domain linker motif; other site
929506003102	Ligand-binding domain of DNA transcription repressor RegR and other putative regulators such as KdgR and EndR; Region: PBP1_RegR_EndR_KdgR_like; cd06283
929506003103	putative dimerization interface [polypeptide binding]; other site
929506003104	putative ligand binding site [chemical binding]; other site
929506003105	arginyl-tRNA synthetase; Reviewed; Region: PRK12451
929506003106	Arginyl tRNA synthetase N terminal dom; Region: Arg_tRNA_synt_N; smart01016
929506003107	catalytic core domain of arginyl-tRNA synthetases; Region: ArgRS_core; cd00671
929506003108	active site
929506003109	HIGH motif; other site
929506003110	KMSK motif region; other site
929506003111	Anticodon-binding domain of arginyl tRNA synthetases; Region: Anticodon_Ia_Arg; cd07956
929506003112	tRNA binding surface [nucleotide binding]; other site
929506003113	anticodon binding site; other site
929506003114	Sugar-specific transcriptional regulator TrmB; Region: TrmB; cl17775
929506003115	Transcriptional regulators containing an AAA-type ATPase domain and a DNA-binding domain [Transcription / Signal transduction mechanisms]; Region: PspF; COG1221
929506003116	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
929506003117	Walker A motif; other site
929506003118	ATP binding site [chemical binding]; other site
929506003119	Walker B motif; other site
929506003120	arginine finger; other site
929506003121	Transcriptional antiterminator [Transcription]; Region: COG3933
929506003122	PRD domain; Region: PRD; pfam00874
929506003123	PTS_IIA, PTS system, mannose/sorbose specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIA_man; cd00006
929506003124	active pocket/dimerization site; other site
929506003125	active site
929506003126	phosphorylation site [posttranslational modification]
929506003127	PRD domain; Region: PRD; pfam00874
929506003128	PTS_IIA, PTS system, mannose/sorbose specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIA_man; cd00006
929506003129	active pocket/dimerization site; other site
929506003130	active site
929506003131	phosphorylation site [posttranslational modification]
929506003132	PTS_IIB, PTS system, Mannose/sorbose specific IIB subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIB_man; cd00001
929506003133	active site
929506003134	phosphorylation site [posttranslational modification]
929506003135	PTS system mannose-specific transporter subunit IIC; Provisional; Region: PRK15065
929506003136	PTS system mannose/fructose/sorbose family IID component; Region: EIID-AGA; cl01507
929506003137	Phosphomannose isomerase [Carbohydrate transport and metabolism]; Region: ManA; COG1482
929506003138	Alpha-Mannosidase Binding Domain of Atg19/34; Region: ABD; cl15429
929506003139	RNase_H superfamily; Region: RNase_H_2; pfam13482
929506003140	active site
929506003141	substrate binding site [chemical binding]; other site
929506003142	catalytic site [active]
929506003143	Fe2+ transport system protein B [Inorganic ion transport and metabolism]; Region: FeoB; COG0370
929506003144	Ferrous iron transport protein B (FeoB) family; Region: FeoB; cd01879
929506003145	G1 box; other site
929506003146	GTP/Mg2+ binding site [chemical binding]; other site
929506003147	Switch I region; other site
929506003148	G2 box; other site
929506003149	G3 box; other site
929506003150	Switch II region; other site
929506003151	G4 box; other site
929506003152	G5 box; other site
929506003153	Nucleoside recognition; Region: Gate; pfam07670
929506003154	Ferrous iron transport protein B C terminus; Region: FeoB_C; pfam07664
929506003155	Nucleoside recognition; Region: Gate; pfam07670
929506003156	Fe2+ transport system protein A [Inorganic ion transport and metabolism]; Region: FeoA; COG1918
929506003157	RNase_H superfamily; Region: RNase_H_2; pfam13482
929506003158	Type II secretory pathway, prepilin signal peptidase PulO and related peptidases [Cell motility and secretion / Posttranslational modification, protein turnover, chaperones / Intracellular trafficking and secretion]; Region: PulO; COG1989
929506003159	Bacterial Peptidase A24 N-terminal domain; Region: DiS_P_DiS; pfam06750
929506003160	Type IV leader peptidase family; Region: Peptidase_A24; pfam01478
929506003161	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
929506003162	putative substrate translocation pore; other site
929506003163	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
929506003164	Transcriptional regulator [Transcription]; Region: AcrR; COG1309
929506003165	Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440
929506003166	Transcriptional regulators [Transcription]; Region: FadR; COG2186
929506003167	Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377
929506003168	DNA-binding site [nucleotide binding]; DNA binding site
929506003169	This entry represents the C-terminal ligand binding domain of many members of the GntR family; Region: FCD; smart00895
929506003170	L-lactate permease [Energy production and conversion]; Region: LldP; COG1620
929506003171	L-lactate permease; Region: Lactate_perm; cl00701
929506003172	The electron transfer flavoprotein (ETF) serves as a specific electron acceptor for various mitochondrial dehydrogenases. ETF transfers electrons to the main respiratory chain via ETF-ubiquinone oxidoreductase. ETF is an heterodimer that consists of an...; Region: ETF_beta; cd01714
929506003173	Ligand binding site [chemical binding]; other site
929506003174	Electron transfer flavoprotein domain; Region: ETF; pfam01012
929506003175	Electron transfer flavoprotein, alpha subunit [Energy production and conversion]; Region: FixB; COG2025
929506003176	The electron transfer flavoprotein (ETF) serves as a specific electron acceptor for various mitochondrial dehydrogenases. ETF transfers electrons to the main respiratory chain via ETF-ubiquinone oxidoreductase. ETF is an heterodimer that consists of an...; Region: ETF_alpha; cd01715
929506003177	Electron transfer flavoprotein FAD-binding domain; Region: ETF_alpha; pfam00766
929506003178	FAD/FMN-containing dehydrogenases [Energy production and conversion]; Region: GlcD; COG0277
929506003179	FAD binding domain; Region: FAD_binding_4; pfam01565
929506003180	glutamyl-tRNA synthetase; Reviewed; Region: gltX; PRK01406
929506003181	catalytic core domain of discriminating glutamyl-tRNA synthetase; Region: GluRS_core; cd00808
929506003182	active site
929506003183	HIGH motif; other site
929506003184	catalytic core domain of discriminating glutamyl-tRNA synthetase; Region: GluRS_core; cd00808
929506003185	active site
929506003186	KMSKS motif; other site
929506003187	Membrane-associated phospholipid phosphatase [Lipid metabolism]; Region: PgpB; COG0671
929506003188	PAP2_like_2 proteins. PAP2 is a super-family of phosphatases and haloperoxidases. This subgroup, which is specific to bacteria, lacks functional characterization and may act as a membrane-associated lipid phosphatase; Region: PAP2_like_2; cd03392
929506003189	active site
929506003190	Putative peptidoglycan binding domain; Region: PG_binding_1; pfam01471
929506003191	L,D-transpeptidase catalytic domain; Region: YkuD; pfam03734
929506003192	Uncharacterized protein conserved in bacteria [Function unknown]; Region: ErfK; COG1376
929506003193	peptidase; Reviewed; Region: PRK13004
929506003194	Zinc peptidases M18, M20, M28, and M42; Region: Zinc_peptidase_like; cl14876
929506003195	metal binding site [ion binding]; metal-binding site
929506003196	Domain of unknown function (DUF4397); Region: DUF4397; pfam14344
929506003197	Domain of unknown function (DUF4397); Region: DUF4397; pfam14344
929506003198	Leucyl aminopeptidase (aminopeptidase T) [Amino acid transport and metabolism]; Region: AmpS; COG2309
929506003199	Thermophilic metalloprotease (M29); Region: Peptidase_M29; pfam02073
929506003200	D-alanyl-D-alanine carboxypeptidase; Region: Peptidase_S11; pfam00768
929506003201	Beta-lactamase enzyme family; Region: Beta-lactamase2; cl17872
929506003202	Coenzyme A pyrophosphatase (CoAse), a member of the Nudix hydrolase superfamily, functions to catalyze the elimination of oxidized inactive CoA, which can inhibit CoA-utilizing enzymes. The need of CoAses mainly arises under conditions of oxidative...; Region: CoAse; cd03426
929506003203	putative active site [active]
929506003204	putative CoA binding site [chemical binding]; other site
929506003205	nudix motif; other site
929506003206	metal binding site [ion binding]; metal-binding site
929506003207	Uncharacterized ACR, YkgG family COG1556; Region: DUF162; pfam02589
929506003208	nicotinate phosphoribosyltransferase; Validated; Region: PRK09243
929506003209	Nicotinate phosphoribosyltransferase (NAPRTase), subgroup A. Nicotinate phosphoribosyltransferase catalyses the formation of NAMN and PPi from 5-phosphoribosy -1-pyrophosphate (PRPP) and nicotinic acid, this is the first, and also rate limiting, reaction...; Region: NAPRTase_A; cd01570
929506003210	active site
929506003211	Superfamily I DNA and RNA helicases [DNA replication, recombination, and repair]; Region: UvrD; COG0210
929506003212	Part of AAA domain; Region: AAA_19; pfam13245
929506003213	Family description; Region: UvrD_C_2; pfam13538
929506003214	Cell division protein FtsA; Region: FtsA; smart00842
929506003215	Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cl17037
929506003216	Metal-dependent amidase/aminoacylase/carboxypeptidase [General function prediction only]; Region: AbgB; COG1473
929506003217	M20 Peptidase Aminoacylase 1 family; Region: M20_Acy1; cd03886
929506003218	metal binding site [ion binding]; metal-binding site
929506003219	dimer interface [polypeptide binding]; other site
929506003220	Pseudouridylate synthases, 23S RNA-specific [Translation, ribosomal structure and biogenesis]; Region: RluA; COG0564
929506003221	S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site;  Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165
929506003222	RNA binding surface [nucleotide binding]; other site
929506003223	Pseudouridine synthase, RsuA/RluD family; Region: PseudoU_synth_RluCD_like; cd02869
929506003224	active site
929506003225	stage V sporulation protein B; Region: spore_V_B; TIGR02900
929506003226	Stage V sporulation protein B, also known as Stage III sporulation protein F, and related proteins; Region: MATE_SpoVB_like; cd13124
929506003227	stage V sporulation protein B; Region: spore_V_B; TIGR02900
929506003228	Stage V sporulation protein B, also known as Stage III sporulation protein F, and related proteins; Region: MATE_SpoVB_like; cd13124
929506003229	Na+/H+-dicarboxylate symporters [Energy production and conversion]; Region: GltP; COG1301
929506003230	Sodium:dicarboxylate symporter family; Region: SDF; pfam00375
929506003231	Glucose/sorbosone dehydrogenases [Carbohydrate transport and metabolism]; Region: COG2133
929506003232	Zinc dependent phospholipase C (alpha toxin); Region: Zn_dep_PLPC; cd11009
929506003233	Zn binding site [ion binding]; other site
929506003234	B12 binding domain_like associated with radical SAM domain. This domain shows similarity with B12 (adenosylcobamide) binding domains found in several enzymes, such as glutamate mutase, methionine synthase and methylmalonyl-CoA mutase, but it lacks the...; Region: radical_SAM_B12_BD; cd02068
929506003235	Elongator protein 3, MiaB family, Radical SAM; Region: Elp3; smart00729
929506003236	Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335
929506003237	FeS/SAM binding site; other site
929506003238	Protein of unknown function (DUF4080); Region: DUF4080; pfam13311
929506003239	V-type ATP synthase subunit H; Validated; Region: PRK08404
929506003240	V-type ATP synthase subunit I; Validated; Region: PRK05771
929506003241	V-type ATP synthase subunit K; Validated; Region: PRK06558
929506003242	ATP synthase subunit C; Region: ATP-synt_C; pfam00137
929506003243	ATP synthase subunit C; Region: ATP-synt_C; pfam00137
929506003244	V-type ATP synthase subunit E; Provisional; Region: PRK03963; cl17074
929506003245	ATP synthase (E/31 kDa) subunit; Region: vATP-synt_E; pfam01991
929506003246	Archaeal/vacuolar-type H+-ATPase subunit C [Energy production and conversion]; Region: NtpC; COG1527
929506003247	V-type ATP synthase subunit C; Provisional; Region: PRK01198
929506003248	V-type ATP synthase subunit F; Provisional; Region: PRK01395
929506003249	V-type ATP synthase subunit A; Provisional; Region: PRK04192
929506003250	ATP synthase alpha/beta family, beta-barrel domain; Region: ATP-synt_ab_N; pfam02874
929506003251	V/A-type ATP synthase catalytic subunit A. These ATPases couple ATP hydrolysis to the build up of a H+ gradient, but V-type ATPases do not catalyze the reverse reaction.  The Vacuolar (V-type) ATPase is found in the membranes of vacuoles, the golgi...; Region: V_A-ATPase_A; cd01134
929506003252	Walker A motif/ATP binding site; other site
929506003253	Walker B motif; other site
929506003254	ATP synthase alpha/beta chain, C terminal domain; Region: ATP-synt_ab_C; pfam00306
929506003255	V-type ATP synthase subunit B; Provisional; Region: PRK04196
929506003256	ATP synthase alpha/beta family, beta-barrel domain; Region: ATP-synt_ab_N; pfam02874
929506003257	V/A-type ATP synthase (non-catalytic) subunit B. These ATPases couple ATP hydrolysis to the build up of a H+ gradient, but V-type ATPases do not catalyze the reverse reaction. The Vacuolar (V-type) ATPase is found in the membranes of vacuoles, the golgi...; Region: V_A-ATPase_B; cd01135
929506003258	Walker A motif homologous position; other site
929506003259	Walker B motif; other site
929506003260	ATP synthase alpha/beta chain, C terminal domain; Region: ATP-synt_ab_C; pfam00306
929506003261	V-type ATP synthase subunit D; Reviewed; Region: PRK00373
929506003262	Polypeptide or peptide deformylase; a family of metalloenzymes that catalyzes the removal of the N-terminal formyl group in a growing polypeptide chain following translation initiation during protein synthesis in prokaryotes. These enzymes utilize Fe(II)...; Region: Pep_deformylase; cd00487
929506003263	active site
929506003264	catalytic residues [active]
929506003265	metal binding site [ion binding]; metal-binding site
929506003266	Uncharacterized flavoproteins [Energy production and conversion]; Region: FpaA; COG0426
929506003267	Metallo-beta-lactamase superfamily; Region: Lactamase_B; smart00849
929506003268	Flavodoxin-like fold; Region: Flavodoxin_2; cl00438
929506003269	Bacterial fructose-1,6-bisphosphatase, glpX-encoded; Region: FBPase_glpX; pfam03320
929506003270	Bacterial fructose-1,6-bisphosphatase, glpX-encoded. A dimeric enzyme dependent on Mg(2+). glpX-encoded FPBase (FBPase class II) differs from other members of the inositol-phosphatase superfamily by permutation of secondary structure elements. The core...; Region: FBPase_glpX; cd01516
929506003271	putative active site [active]
929506003272	HPr kinase/phosphorylase; Provisional; Region: PRK05428
929506003273	HPr Serine kinase N terminus; Region: Hpr_kinase_N; pfam02603
929506003274	HprK/P, the bifunctional histidine-containing protein kinase/phosphatase, controls the phosphorylation state of the phosphocarrier protein HPr and regulates the utilization of carbon sources by gram-positive bacteria. It catalyzes both the ATP-dependent...; Region: HprK_C; cd01918
929506003275	Hpr binding site; other site
929506003276	active site
929506003277	homohexamer subunit interaction site [polypeptide binding]; other site
929506003278	5-formyltetrahydrofolate cyclo-ligase family; Region: 5-FTHF_cyc-lig; pfam01812
929506003279	5,10-methenyltetrahydrofolate synthetase; Region: MTHFS_bact; TIGR02727
929506003280	Thermotoga maritima CorA-like family; Region: TmCorA-like; cd12822
929506003281	oligomer interface [polypeptide binding]; other site
929506003282	metal binding site [ion binding]; metal-binding site
929506003283	CorA-like Mg2+ transporter protein; Region: CorA; pfam01544
929506003284	putative Cl binding site [ion binding]; other site
929506003285	aspartate ring; other site
929506003286	basic sphincter; other site
929506003287	hydrophobic gate; other site
929506003288	periplasmic entrance; other site
929506003289	M18 Peptidase Aminopeptidase I; Region: M18_API; cd05659
929506003290	Aminopeptidase I zinc metalloprotease (M18); Region: Peptidase_M18; pfam02127
929506003291	oligomer interface [polypeptide binding]; other site
929506003292	putative active site [active]
929506003293	metal binding site [ion binding]; metal-binding site
929506003294	Predicted metal-dependent phosphoesterases (PHP family) [General function prediction only]; Region: COG0613
929506003295	Polymerase and Histidinol Phosphatase domain of Histidinol phosphate phosphatase (HisPPase) AMP bound; Region: PHP_HisPPase_AMP; cd07438
929506003296	active site
929506003297	Polymerase and Histidinol Phosphatase domain of Histidinol phosphate phosphatase (HisPPase) AMP bound; Region: PHP_HisPPase_AMP; cd07438
929506003298	Predicted Zn-dependent peptidases, insulinase-like [General function prediction only]; Region: COG1026
929506003299	Insulinase (Peptidase family M16); Region: Peptidase_M16; pfam00675
929506003300	Peptidase M16 inactive domain; Region: Peptidase_M16_C; pfam05193
929506003301	Peptidase M16C associated; Region: M16C_assoc; pfam08367
929506003302	Branched-chain amino acid transport protein; Region: Branch_AA_trans; cl00547
929506003303	NPCBM/NEW2 domain; Region: NPCBM; cl07060
929506003304	Protein of unknown function (DUF2762); Region: DUF2762; pfam10960
929506003305	helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347
929506003306	MarR family; Region: MarR_2; pfam12802
929506003307	Fusaric acid resistance protein-like; Region: FUSC_2; pfam13515
929506003308	CAAX protease self-immunity; Region: Abi; pfam02517
929506003309	Transcriptional regulators of sugar metabolism [Transcription / Carbohydrate transport and metabolism]; Region: GlpR; COG1349
929506003310	helix_turn_helix, Deoxyribose operon repressor; Region: HTH_DEOR; smart00420
929506003311	DeoR C terminal sensor domain; Region: DeoRC; pfam00455
929506003312	methylthioribose kinase; Reviewed; Region: mtnK; PRK09550
929506003313	Phosphotransferase enzyme family; Region: APH; pfam01636
929506003314	methylthioribose-1-phosphate isomerase; Reviewed; Region: mtnA; PRK05720
929506003315	S-methyl-5-thioribose-1-phosphate isomerase; Region: salvage_mtnA; TIGR00512
929506003316	Phosphotransferase system, galactitol-specific IIC component [Carbohydrate transport and metabolism]; Region: GatC; COG3775
929506003317	PTS system sugar-specific permease component; Region: EIIC-GAT; cl04451
929506003318	Ribulose-5-phosphate 4-epimerase and related epimerases and aldolases [Carbohydrate transport and metabolism]; Region: AraD; COG0235
929506003319	intersubunit interface [polypeptide binding]; other site
929506003320	active site
929506003321	Zn2+ binding site [ion binding]; other site
929506003322	Predicted membrane protein (DUF2238); Region: DUF2238; pfam09997
929506003323	DNA polymerase I; Provisional; Region: PRK05755
929506003324	PIN domain of the 5'-3' exonuclease of Taq DNA polymerase I and homologs; Region: PIN_53EXO; cd09859
929506003325	active site
929506003326	metal binding site 1 [ion binding]; metal-binding site
929506003327	putative 5' ssDNA interaction site; other site
929506003328	metal binding site 3; metal-binding site
929506003329	metal binding site 2 [ion binding]; metal-binding site
929506003330	H3TH domain of the 5'-3' exonuclease of Taq DNA polymerase I and homologs; Region: H3TH_53EXO; cd09898
929506003331	putative DNA binding site [nucleotide binding]; other site
929506003332	putative metal binding site [ion binding]; other site
929506003333	inactive DEDDy 3'-5' exonuclease domain of Bacillus stearothermophilus DNA polymerase I and similar family-A DNA polymerases; Region: DNA_polA_I_Bacillus_like_exo; cd06140
929506003334	Polymerase I functions primarily to fill DNA gaps that arise during DNA repair, recombination and replication; Region: DNA_pol_A_pol_I_C; cd08637
929506003335	active site
929506003336	DNA binding site [nucleotide binding]
929506003337	catalytic site [active]
929506003338	Dephospho-CoA kinase [Coenzyme metabolism]; Region: CoaE; COG0237
929506003339	Dephospho-coenzyme A kinase (DPCK, EC 2.7.1.24) catalyzes the phosphorylation of dephosphocoenzyme A (dCoA) to yield CoA, which is the final step in CoA biosynthesis; Region: DPCK; cd02022
929506003340	CoA-binding site [chemical binding]; other site
929506003341	ATP-binding [chemical binding]; other site
929506003342	Soluble lytic murein transglycosylase and related regulatory proteins (some contain LysM/invasin domains) [Cell envelope biogenesis, outer membrane]; Region: MltE; COG0741
929506003343	Lytic Transglycosylase (LT)  and Goose Egg White Lysozyme (GEWL) domain. Members include the soluble and insoluble membrane-bound LTs in bacteria, the LTs in bacteriophage lambda, as well as, the eukaryotic "goose-type" lysozymes (GEWL).  LTs...; Region: LT_GEWL; cd00254
929506003344	N-acetyl-D-glucosamine binding site [chemical binding]; other site
929506003345	catalytic residue [active]
929506003346	hypothetical protein; Provisional; Region: PRK04435
929506003347	Helix-turn-helix domain of Hin and related proteins, a family of DNA-binding domains unique to bacteria and represented by the Hin protein of Salmonella. The basic HTH domain is a simple fold comprised of three core helices that form a right-handed...; Region: HTH_Hin_like; cl17393
929506003348	DNA-binding interface [nucleotide binding]; DNA binding site
929506003349	C-terminal ACT domain of a small (; 147 a.a.) putative phenylalanine biosynthetic pathway protein described in Bacillus subtilis (BS) PheB (PheB-BS) and related domains; Region: ACT_PheB-BS; cd04888
929506003350	Acetyltransferase (GNAT) domain; Region: Acetyltransf_4; pfam13420
929506003351	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl17182
929506003352	Coenzyme A binding pocket [chemical binding]; other site
929506003353	Sporulation related domain; Region: SPOR; cl10051
929506003354	Domain of unknown function (DUF4321); Region: DUF4321; pfam14209
929506003355	Maf-like protein; Reviewed; Region: PRK00078
929506003356	Nucleotide binding protein Maf. Maf has been implicated in inhibition of septum formation in eukaryotes, bacteria and archaea, but homologs in B.subtilis and S.cerevisiae are nonessential for cell division. Maf has been predicted to be a nucleotide- or...; Region: Maf; cd00555
929506003357	active site
929506003358	dimer interface [polypeptide binding]; other site
929506003359	hypothetical protein; Reviewed; Region: PRK00024
929506003360	Mov34/MPN/PAD-1 family; Region: MPN_DUF2466; cd08071
929506003361	MPN+ (JAMM) motif; other site
929506003362	Zinc-binding site [ion binding]; other site
929506003363	rod shape-determining protein MreB; Provisional; Region: PRK13927
929506003364	MreB and similar proteins; Region: MreB_like; cd10225
929506003365	nucleotide binding site [chemical binding]; other site
929506003366	Mg binding site [ion binding]; other site
929506003367	putative protofilament interaction site [polypeptide binding]; other site
929506003368	RodZ interaction site [polypeptide binding]; other site
929506003369	rod shape-determining protein MreC; Provisional; Region: PRK13922
929506003370	rod shape-determining protein MreC; Region: MreC; pfam04085
929506003371	rod shape-determining protein MreD; Region: shape_MreD; TIGR03426
929506003372	Penicillin-binding Protein dimerisation domain; Region: PBP_dimer; pfam03717
929506003373	Penicillin-binding Protein dimerisation domain; Region: PBP_dimer; pfam03717
929506003374	Penicillin binding protein transpeptidase domain; Region: Transpeptidase; cl17760
929506003375	Penicillin binding protein transpeptidase domain; Region: Transpeptidase; cl17760
929506003376	Penicillin binding protein transpeptidase domain; Region: Transpeptidase; cl17760
929506003377	septum formation inhibitor; Reviewed; Region: minC; PRK00513
929506003378	Septum formation inhibitor MinC, C-terminal domain; Region: MinC_C; pfam03775
929506003379	septum site-determining protein MinD; Region: minD_bact; TIGR01968
929506003380	Bacterial cell division requires the formation of a septum at mid-cell. The site is determined by the min operon products MinC, MinD and MinE. MinC is a nonspecific inhibitor of the septum protein FtsZ. MinE is the supressor of MinC. MinD plays a pivotal...; Region: MinD; cd02036
929506003381	Switch I; other site
929506003382	Switch II; other site
929506003383	cell division topological specificity factor MinE; Provisional; Region: PRK13987
929506003384	rod shape-determining protein RodA; Region: rodA_shape; TIGR02210
929506003385	Methylglyoxal synthase catalyzes the enolization of dihydroxyacetone phosphate (DHAP) to produce methylglyoxal. The first part of the catalytic mechanism is believed to be similar to TIM (triosephosphate isomerase) in that both enzymes utilize DHAP to...; Region: MGS; cd01422
929506003386	active site
929506003387	dimer interfaces [polypeptide binding]; other site
929506003388	catalytic residues [active]
929506003389	transposase/IS protein; Provisional; Region: PRK09183
929506003390	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
929506003391	Walker A motif; other site
929506003392	ATP binding site [chemical binding]; other site
929506003393	Walker B motif; other site
929506003394	arginine finger; other site
929506003395	Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392
929506003396	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG4584
929506003397	DNA binding site [nucleotide binding]
929506003398	Integrase core domain; Region: rve; pfam00665
929506003399	RT_G2_intron: Reverse transcriptases (RTs) with group II intron origin. RT transcribes DNA using RNA as template. Proteins in this subfamily are found in bacterial and mitochondrial group II introns. Their most probable ancestor was a retrotransposable...; Region: RT_G2_intron; cd01651
929506003400	Reverse transcriptase (RNA-dependent DNA polymerase); Region: RVT_1; pfam00078
929506003401	putative active site [active]
929506003402	putative NTP binding site [chemical binding]; other site
929506003403	putative nucleic acid binding site [nucleotide binding]; other site
929506003404	Group II intron, maturase-specific domain; Region: GIIM; pfam08388
929506003405	Na+/H+ antiporter NhaD and related arsenite permeases [Inorganic ion transport and metabolism]; Region: ArsB; COG1055
929506003406	Anion permease ArsB/NhaD.  These permeases have been shown to translocate sodium, arsenate, antimonite, sulfate and organic anions across biological membranes in all three kingdoms of life.  A typical anion permease contains 8-13 transmembrane helices...; Region: ArsB_NhaD_permease; cl17221
929506003407	transmembrane helices; other site
929506003408	4Fe-4S binding domain; Region: Fer4; pfam00037
929506003409	[FeFe] hydrogenase, group A; Region: FeFe_hydrog_A; TIGR02512
929506003410	4Fe-4S binding domain; Region: Fer4; pfam00037
929506003411	Iron only hydrogenase large subunit, C-terminal domain; Region: Fe_hyd_lg_C; pfam02906
929506003412	Iron hydrogenase small subunit; Region: Fe_hyd_SSU; pfam02256
929506003413	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3330
929506003414	Uncharacterized conserved protein [Function unknown]; Region: COG1543
929506003415	N-terminal catalytic domain of  alpha-amylase ( AmyC ) and similar proteins; Region: GH57N_AmyC_like; cd10792
929506003416	active site
929506003417	substrate binding site [chemical binding]; other site
929506003418	catalytic site [active]
929506003419	Domain of unknown function (DUF1957); Region: DUF1957; pfam09210
929506003420	Predicted Zn-dependent peptidases [General function prediction only]; Region: PqqL; COG0612
929506003421	Insulinase (Peptidase family M16); Region: Peptidase_M16; pfam00675
929506003422	Peptidase M16 inactive domain; Region: Peptidase_M16_C; pfam05193
929506003423	recombination regulator RecX; Provisional; Region: recX; PRK14134
929506003424	Transglutaminase-like enzymes, putative cysteine proteases [Amino acid transport and metabolism]; Region: COG1305
929506003425	Transglutaminase-like superfamily; Region: Transglut_core; pfam01841
929506003426	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
929506003427	Tetratricopeptide repeat; Region: TPR_12; pfam13424
929506003428	binding surface
929506003429	TPR motif; other site
929506003430	ABC-type nitrate/sulfonate/bicarbonate transport system, permease component [Inorganic ion transport and metabolism]; Region: TauC; COG0600
929506003431	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
929506003432	dimer interface [polypeptide binding]; other site
929506003433	conserved gate region; other site
929506003434	putative PBP binding loops; other site
929506003435	ABC-ATPase subunit interface; other site
929506003436	ABC-type nitrate/sulfonate/bicarbonate transport system, ATPase component [Inorganic ion transport and metabolism]; Region: TauB; COG1116
929506003437	ATP-binding cassette domain of the nitrate and sulfonate transporters; Region: ABC_NrtD_SsuB_transporters; cd03293
929506003438	Walker A/P-loop; other site
929506003439	ATP binding site [chemical binding]; other site
929506003440	Q-loop/lid; other site
929506003441	ABC transporter signature motif; other site
929506003442	Walker B; other site
929506003443	D-loop; other site
929506003444	H-loop/switch region; other site
929506003445	BadF/BadG/BcrA/BcrD ATPase family; Region: BcrAD_BadFG; cl17271
929506003446	Activator of 2-hydroxyglutaryl-CoA dehydratase (HSP70-class ATPase domain) [Lipid metabolism]; Region: COG1924
929506003447	BadF/BadG/BcrA/BcrD ATPase family; Region: BcrAD_BadFG; cl17271
929506003448	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3580
929506003449	2-hydroxyglutaryl-CoA dehydratase, D-component; Region: HGD-D; pfam06050
929506003450	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3581
929506003451	ABC-type nitrate/sulfonate/bicarbonate transport systems, periplasmic components [Inorganic ion transport and metabolism]; Region: TauA; COG0715
929506003452	Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of  substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cl17432
929506003453	Site-specific recombinases, DNA invertase Pin homologs [DNA replication, recombination, and repair]; Region: PinR; COG1961
929506003454	Serine Recombinase family, catalytic domain; a DNA binding domain may be present either N- or C-terminal to the catalytic domain. These enzymes perform site-specific recombination of DNA molecules by a concerted, four-strand cleavage and rejoining...; Region: Ser_Recombinase; cd00338
929506003455	catalytic residues [active]
929506003456	catalytic nucleophile [active]
929506003457	Recombinase; Region: Recombinase; pfam07508
929506003458	Recombinase zinc beta ribbon domain; Region: Zn_ribbon_recom; pfam13408
929506003459	Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of  substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cl17432
929506003460	Fructose-1-phosphate kinase and related fructose-6-phosphate kinase (PfkB) [Carbohydrate transport and metabolism]; Region: FruK; COG1105
929506003461	1-phosphofructokinase (FruK), minor 6-phosphofructokinase (pfkB) and related sugar kinases. FruK plays an important role in the predominant pathway for fructose utilisation.This group also contains tagatose-6-phophate kinase, an enzyme of the tagatose...; Region: FruK_PfkB_like; cd01164
929506003462	putative substrate binding site [chemical binding]; other site
929506003463	putative ATP binding site [chemical binding]; other site
929506003464	Domain of unknown function DUF11; Region: DUF11; cl17728
929506003465	valyl-tRNA synthetase; Reviewed; Region: valS; PRK05729
929506003466	nucleotidyl transferase superfamily; Region: nt_trans; cl00015
929506003467	active site
929506003468	HIGH motif; other site
929506003469	nucleotide binding site [chemical binding]; other site
929506003470	Leucyl-tRNA synthetase, Domain 2; Region: tRNA-synt_1_2; pfam13603
929506003471	catalytic core domain of valyl-tRNA synthetases; Region: ValRS_core; cd00817
929506003472	active site
929506003473	KMSKS motif; other site
929506003474	Anticodon-binding domain of valyl tRNA synthetases; Region: Anticodon_Ia_Val; cd07962
929506003475	tRNA binding surface [nucleotide binding]; other site
929506003476	anticodon binding site; other site
929506003477	Valyl tRNA synthetase tRNA binding arm; Region: Val_tRNA-synt_C; pfam10458
929506003478	Folylpolyglutamate synthase [Coenzyme metabolism]; Region: FolC; COG0285
929506003479	Mur ligase middle domain; Region: Mur_ligase_M; pfam08245
929506003480	Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875
929506003481	Predicted permease, member of the PurR regulon [General function prediction only]; Region: yhhT; COG0628
929506003482	Domain of unknown function DUF20; Region: UPF0118; pfam01594
929506003483	Alkyladenine DNA glycosylase catalyzes the first step in base excision repair; Region: AAG; cd00540
929506003484	active site
929506003485	DNA binding site [nucleotide binding]
929506003486	TSCPD domain; Region: TSCPD; cl14834
929506003487	Uncharacterized conserved protein [Function unknown]; Region: COG3391
929506003488	40-residue YVTN family beta-propeller repeat; Region: beta_rpt_yvtn; TIGR02276
929506003489	Domain of unknown function (DUF4364); Region: DUF4364; pfam14277
929506003490	Predicted xylanase/chitin deacetylase [Carbohydrate transport and metabolism]; Region: CDA1; COG0726
929506003491	Catalytic NodB homology domain of rhizobial NodB-like proteins; Region: CE4_NodB_like_6s_7s; cd10917
929506003492	NodB motif; other site
929506003493	active site
929506003494	catalytic site [active]
929506003495	metal binding site [ion binding]; metal-binding site
929506003496	single-stranded DNA-binding protein; Provisional; Region: PRK05813
929506003497	SSB_OBF: A subfamily of OB folds similar to the OB fold of ssDNA-binding protein (SSB). SSBs bind with high affinity to ssDNA. They bind to and protect ssDNA intermediates during DNA metabolic pathways. All bacterial and eukaryotic SSBs studied to date...; Region: SSB_OBF; cd04496
929506003498	dimer interface [polypeptide binding]; other site
929506003499	ssDNA binding site [nucleotide binding]; other site
929506003500	tetramer (dimer of dimers) interface [polypeptide binding]; other site
929506003501	Tetrahydrodipicolinate succinyltransferase N-terminal; Region: DapH_N; pfam08503
929506003502	2,3,4,5-tetrahydropyridine-2,6-dicarboxylate (THDP) N-succinyltransferase (also called THP succinyltransferase): THDP N-succinyltransferase catalyzes the conversion of tetrahydrodipicolinate and succinyl-CoA to N-succinyltetrahydrodipicolinate and CoA; Region: LbH_THP_succinylT; cd03350
929506003503	active site
929506003504	trimer interface [polypeptide binding]; other site
929506003505	substrate binding site [chemical binding]; other site
929506003506	CoA binding site [chemical binding]; other site
929506003507	aminotransferase A; Validated; Region: PRK07683
929506003508	Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609
929506003509	pyridoxal 5'-phosphate binding site [chemical binding]; other site
929506003510	homodimer interface [polypeptide binding]; other site
929506003511	catalytic residue [active]
929506003512	The substrate-binding component of an ABC-type oligopetide import system contains the type 2 periplasmic binding fold; Region: PBP2_OppA; cd08504
929506003513	peptide binding site [polypeptide binding]; other site
929506003514	Bacterial extracellular solute-binding proteins, family 5 Middle; Region: SBP_bac_5; pfam00496
929506003515	ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppB; COG0601
929506003516	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
929506003517	dimer interface [polypeptide binding]; other site
929506003518	conserved gate region; other site
929506003519	putative PBP binding loops; other site
929506003520	ABC-ATPase subunit interface; other site
929506003521	ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppC; COG1173
929506003522	N-terminal TM domain of oligopeptide transport permease C; Region: OppC_N; pfam12911
929506003523	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
929506003524	dimer interface [polypeptide binding]; other site
929506003525	conserved gate region; other site
929506003526	putative PBP binding loops; other site
929506003527	ABC-ATPase subunit interface; other site
929506003528	ABC-type dipeptide/oligopeptide/nickel transport system, ATPase component [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppD; COG0444
929506003529	ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257
929506003530	Walker A/P-loop; other site
929506003531	ATP binding site [chemical binding]; other site
929506003532	Q-loop/lid; other site
929506003533	ABC transporter signature motif; other site
929506003534	Walker B; other site
929506003535	D-loop; other site
929506003536	H-loop/switch region; other site
929506003537	oligopeptide/dipeptide ABC transporter, ATP-binding protein, C-terminal domain; Region: oligo_HPY; TIGR01727
929506003538	oligopeptide ABC transporter ATP-binding protein OppF; Provisional; Region: PRK15079
929506003539	ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257
929506003540	Walker A/P-loop; other site
929506003541	ATP binding site [chemical binding]; other site
929506003542	Q-loop/lid; other site
929506003543	ABC transporter signature motif; other site
929506003544	Walker B; other site
929506003545	D-loop; other site
929506003546	H-loop/switch region; other site
929506003547	oligopeptide/dipeptide ABC transporter, ATP-binding protein, C-terminal domain; Region: oligo_HPY; TIGR01727
929506003548	Transposase domain (DUF772); Region: DUF772; pfam05598
929506003549	Transposase DDE domain; Region: DDE_Tnp_1_6; pfam13751
929506003550	dihydrodipicolinate reductase; Provisional; Region: PRK00048
929506003551	Dihydrodipicolinate reductase, N-terminus; Region: DapB_N; pfam01113
929506003552	Dihydrodipicolinate reductase, C-terminus; Region: DapB_C; pfam05173
929506003553	Dihydrodipicolinate synthase/N-acetylneuraminate lyase [Amino acid transport and metabolism / Cell envelope biogenesis, outer membrane]; Region: DapA; COG0329
929506003554	Dihydrodipicolinate synthase (DHDPS); Region: DHDPS; cd00950
929506003555	dimer interface [polypeptide binding]; other site
929506003556	active site
929506003557	catalytic residue [active]
929506003558	aspartate-semialdehyde dehydrogenase; Provisional; Region: PRK14874
929506003559	Semialdehyde dehydrogenase, NAD binding domain; Region: Semialdhyde_dh; smart00859
929506003560	Small, acid-soluble spore proteins, alpha/beta type; Region: SASP; pfam00269
929506003561	Methyltransferase domain; Region: Methyltransf_31; pfam13847
929506003562	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
929506003563	S-adenosylmethionine binding site [chemical binding]; other site
929506003564	Hsp33-like chaperonin; Reviewed; Region: hslO; PRK00114
929506003565	Heat shock protein 33 (Hsp33):  Cytosolic protein that acts as a molecular chaperone under oxidative conditions.  In normal (reducing) cytosolic conditions, four conserved Cys residues are coordinated by a Zn ion. Under oxidative stress (such as heat...; Region: Hsp33; cd00498
929506003566	dimerization interface [polypeptide binding]; other site
929506003567	domain crossover interface; other site
929506003568	redox-dependent activation switch; other site
929506003569	Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392
929506003570	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG4584
929506003571	DNA binding site [nucleotide binding]
929506003572	Integrase core domain; Region: rve; pfam00665
929506003573	transposase/IS protein; Provisional; Region: PRK09183
929506003574	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
929506003575	Walker A motif; other site
929506003576	ATP binding site [chemical binding]; other site
929506003577	Walker B motif; other site
929506003578	arginine finger; other site
929506003579	maltose O-acetyltransferase; Provisional; Region: PRK10092
929506003580	Maltose O-acetyltransferase (MAT) and Galactoside O-acetyltransferase (GAT): MAT and GAT catalyze the CoA-dependent acetylation of the 6-hydroxyl group of their respective sugar substrates. MAT acetylates maltose and glucose exclusively at the C6...; Region: LbH_MAT_GAT; cd03357
929506003581	active site
929506003582	substrate binding site [chemical binding]; other site
929506003583	trimer interface [polypeptide binding]; other site
929506003584	CoA binding site [chemical binding]; other site
929506003585	Phage-related protein [Function unknown]; Region: PblB; COG4926
929506003586	Phosphotransferase system, mannose/fructose/N-acetylgalactosamine-specific component IID [Carbohydrate transport and metabolism]; Region: ManZ; COG3716
929506003587	Phosphotransferase system, mannose/fructose/N-acetylgalactosamine-specific component IIC [Carbohydrate transport and metabolism]; Region: ManY; COG3715
929506003588	PTS system sorbose subfamily IIB component; Region: PTSIIB_sorb; pfam03830
929506003589	active site
929506003590	phosphorylation site [posttranslational modification]
929506003591	PTS_IIA, PTS system, mannose/sorbose specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIA_man; cd00006
929506003592	active pocket/dimerization site; other site
929506003593	active site
929506003594	phosphorylation site [posttranslational modification]
929506003595	Transposase domain (DUF772); Region: DUF772; pfam05598
929506003596	Transposase DDE domain; Region: DDE_Tnp_1_6; pfam13751
929506003597	YtxC-like family; Region: YtxC; pfam08812
929506003598	threonyl-tRNA synthetase; Reviewed; Region: thrS; PRK00413
929506003599	TGS _ThrRS_N:  ThrRS (threonyl-tRNA Synthetase)  is a class II tRNA synthetase that couples threonine to its cognate tRNA.  In addition to its catalytic and anticodon-binding domains, ThrRS has an N-terminal TGS domain, named after the ThrRS, GTPase, and...; Region: TGS_ThrRS_N; cd01667
929506003600	Threonyl and Alanyl tRNA synthetase second additional domain; Region: tRNA_SAD; smart00863
929506003601	Threonyl-tRNA synthetase (ThrRS) class II core catalytic domain. ThrRS is a homodimer. It is responsible for the attachment of threonine to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for ATP-dependent...; Region: ThrRS_core; cd00771
929506003602	active site
929506003603	dimer interface [polypeptide binding]; other site
929506003604	motif 1; other site
929506003605	motif 2; other site
929506003606	motif 3; other site
929506003607	ThrRS Threonyl-anticodon binding domain. ThrRS belongs to class II aminoacyl-tRNA synthetases (aaRS). This alignment contains the anticodon binding domain, which is responsible for specificity in tRNA-binding, so that the activated amino acid is...; Region: ThrRS_anticodon; cd00860
929506003608	anticodon binding site; other site
929506003609	translation initiation factor IF-3; Reviewed; Region: infC; PRK00028
929506003610	Translation initiation factor IF-3, N-terminal domain; Region: IF3_N; pfam05198
929506003611	Translation initiation factor IF-3, C-terminal domain; Region: IF3_C; pfam00707
929506003612	50S ribosomal protein L35; Reviewed; Region: rpmI; PRK00172
929506003613	Ribosomal protein L20; Region: Ribosomal_L20; cd07026
929506003614	23S rRNA binding site [nucleotide binding]; other site
929506003615	L21 binding site [polypeptide binding]; other site
929506003616	L13 binding site [polypeptide binding]; other site
929506003617	Trk-type K+ transport systems, membrane components [Inorganic ion transport and metabolism]; Region: TrkG; COG0168
929506003618	potassium uptake protein, TrkH family; Region: 2a38; TIGR00933
929506003619	K+ transport systems, NAD-binding component [Inorganic ion transport and metabolism]; Region: TrkA; COG0569
929506003620	TrkA-N domain; Region: TrkA_N; pfam02254
929506003621	TrkA-C domain; Region: TrkA_C; pfam02080
929506003622	rRNA methylases [Translation, ribosomal structure and biogenesis]; Region: SpoU; COG0566
929506003623	RNA 2'-O ribose methyltransferase substrate binding; Region: SpoU_sub_bind; smart00967
929506003624	SpoU rRNA Methylase family; Region: SpoU_methylase; pfam00588
929506003625	phenylalanyl-tRNA synthetase subunit alpha; Validated; Region: pheS; PRK00488
929506003626	Aminoacyl tRNA synthetase class II, N-terminal domain; Region: Phe_tRNA-synt_N; pfam02912
929506003627	Phenylalanyl-tRNA synthetase (PheRS) alpha chain catalytic core domain. PheRS belongs to class II aminoacyl-tRNA synthetases (aaRS) based upon its structure and the presence of three characteristic sequence motifs. This domain is primarily responsible...; Region: PheRS_alpha_core; cd00496
929506003628	dimer interface [polypeptide binding]; other site
929506003629	motif 1; other site
929506003630	active site
929506003631	motif 2; other site
929506003632	motif 3; other site
929506003633	phenylalanyl-tRNA synthetase subunit beta; Reviewed; Region: pheT; PRK00629
929506003634	tRNA-binding-domain-containing prokaryotic phenylalanly tRNA synthetase (PheRS) beta chain.  PheRS aminoacylate phenylalanine transfer RNAs (tRNAphe). PheRSs belong structurally to class II aminoacyl tRNA synthetases (aaRSs) but, as they aminoacylate...; Region: tRNA_bind_bactPheRS; cd02796
929506003635	putative tRNA-binding site [nucleotide binding]; other site
929506003636	B3/4 domain; Region: B3_4; pfam03483
929506003637	tRNA synthetase B5 domain; Region: B5; smart00874
929506003638	Phenylalanyl-tRNA synthetase (PheRS) beta chain core domain. PheRS belongs to class II aminoacyl-tRNA synthetases (aaRS) based upon its structure. While class II aaRSs generally aminoacylate the 3'-OH ribose of the appropriate tRNA,  PheRS is an...; Region: PheRS_beta_core; cd00769
929506003639	dimer interface [polypeptide binding]; other site
929506003640	motif 1; other site
929506003641	motif 3; other site
929506003642	motif 2; other site
929506003643	Ferredoxin-fold anticodon binding domain; Region: FDX-ACB; pfam03147
929506003644	Cell division protein ZapA; Region: ZapA; pfam05164
929506003645	Domain of unknown function DUF11; Region: DUF11; cl17728
929506003646	Domain of unknown function DUF11; Region: DUF11; cl17728
929506003647	conserved repeat domain; Region: B_ant_repeat; TIGR01451
929506003648	conserved repeat domain; Region: B_ant_repeat; TIGR01451
929506003649	fimbrial isopeptide formation D2 domain; Region: RrgB_K2N_iso_D2; TIGR04226
929506003650	Domain of unknown function DUF11; Region: DUF11; cl17728
929506003651	Domain of unknown function DUF11; Region: DUF11; cl17728
929506003652	fimbrial isopeptide formation D2 domain; Region: RrgB_K2N_iso_D2; TIGR04226
929506003653	Domain of unknown function DUF11; Region: DUF11; cl17728
929506003654	fimbrial isopeptide formation D2 domain; Region: RrgB_K2N_iso_D2; TIGR04226
929506003655	Domain of unknown function DUF11; Region: DUF11; cl17728
929506003656	fimbrial isopeptide formation D2 domain; Region: RrgB_K2N_iso_D2; TIGR04226
929506003657	fimbrial isopeptide formation D2 domain; Region: RrgB_K2N_iso_D2; TIGR04226
929506003658	fimbrial isopeptide formation D2 domain; Region: RrgB_K2N_iso_D2; TIGR04226
929506003659	fimbrial isopeptide formation D2 domain; Region: RrgB_K2N_iso_D2; TIGR04226
929506003660	fimbrial isopeptide formation D2 domain; Region: RrgB_K2N_iso_D2; TIGR04226
929506003661	fimbrial isopeptide formation D2 domain; Region: RrgB_K2N_iso_D2; TIGR04226
929506003662	conserved repeat domain; Region: B_ant_repeat; TIGR01451
929506003663	Domain of unknown function DUF11; Region: DUF11; cl17728
929506003664	fimbrial isopeptide formation D2 domain; Region: RrgB_K2N_iso_D2; TIGR04226
929506003665	conserved repeat domain; Region: B_ant_repeat; TIGR01451
929506003666	conserved repeat domain; Region: B_ant_repeat; TIGR01451
929506003667	Domain of unknown function DUF11; Region: DUF11; cl17728
929506003668	Domain of unknown function DUF11; Region: DUF11; cl17728
929506003669	Domain of unknown function DUF11; Region: DUF11; cl17728
929506003670	conserved repeat domain; Region: B_ant_repeat; TIGR01451
929506003671	conserved repeat domain; Region: B_ant_repeat; TIGR01451
929506003672	conserved repeat domain; Region: B_ant_repeat; TIGR01451
929506003673	Selenocysteine lyase/Cysteine desulfurase [Posttranslational modification, protein turnover, chaperones]; Region: csdA; COG0520
929506003674	Cysteine desulfurase (SufS)-like. This family belongs to the pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to cysteine desulfurase (SufS) and selenocysteine lyase. SufS...; Region: SufS_like; cd06453
929506003675	pyridoxal 5'-phosphate binding pocket [chemical binding]; other site
929506003676	catalytic residue [active]
929506003677	Transposase domain (DUF772); Region: DUF772; pfam05598
929506003678	Transposase DDE domain; Region: DDE_Tnp_1_6; pfam13751
929506003679	Transposase domain (DUF772); Region: DUF772; pfam05598
929506003680	Transposase DDE domain; Region: DDE_Tnp_1_6; pfam13751
929506003681	Protein of unknown function (DUF3343); Region: DUF3343; pfam11823
929506003682	Copper/zinc superoxide dismutase (SOD). superoxide dismutases catalyse the conversion of superoxide radicals to molecular oxygen. Three evolutionarily distinct families of SODs are known, of which the copper/zinc-binding family is one. Defects in the...; Region: Cu-Zn_Superoxide_Dismutase; cd00305
929506003683	E-class dimer interface [polypeptide binding]; other site
929506003684	P-class dimer interface [polypeptide binding]; other site
929506003685	active site
929506003686	Cu2+ binding site [ion binding]; other site
929506003687	Zn2+ binding site [ion binding]; other site
929506003688	Collagenase and related proteases [Posttranslational modification, protein turnover, chaperones]; Region: COG0826
929506003689	DRE-TIM metallolyase superfamily; Region: DRE_TIM_metallolyase; cl07974
929506003690	Peptidase family U32; Region: Peptidase_U32; pfam01136
929506003691	metal binding site [ion binding]; metal-binding site
929506003692	Collagenase; Region: DUF3656; pfam12392
929506003693	Peptidase family U32; Region: Peptidase_U32; cl03113
929506003694	recombination and DNA strand exchange inhibitor protein; Reviewed; Region: PRK00409
929506003695	MutS domain III; Region: MutS_III; pfam05192
929506003696	ATP-binding cassette domain of MutS2; Region: ABC_MutS2; cd03280
929506003697	Walker A/P-loop; other site
929506003698	ATP binding site [chemical binding]; other site
929506003699	Q-loop/lid; other site
929506003700	ABC transporter signature motif; other site
929506003701	Walker B; other site
929506003702	D-loop; other site
929506003703	H-loop/switch region; other site
929506003704	Smr domain; Region: Smr; pfam01713
929506003705	Uncharacterized conserved protein [Function unknown]; Region: COG1683
929506003706	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
929506003707	Walker A/P-loop; other site
929506003708	ATP binding site [chemical binding]; other site
929506003709	ABC transporter; Region: ABC_tran; pfam00005
929506003710	Q-loop/lid; other site
929506003711	ABC transporter signature motif; other site
929506003712	Walker B; other site
929506003713	D-loop; other site
929506003714	H-loop/switch region; other site
929506003715	50S ribosomal protein L25/general stress protein Ctc; Reviewed; Region: PRK05618
929506003716	Ribosomal L25/TL5/CTC N-terminal 5S rRNA binding domain; Region: Ribosomal_L25_TL5_CTC; cd00495
929506003717	5S rRNA interface [nucleotide binding]; other site
929506003718	CTC domain interface [polypeptide binding]; other site
929506003719	L16 interface [polypeptide binding]; other site
929506003720	Phosphomannomutase [Carbohydrate transport and metabolism]; Region: {ManB}; COG1109
929506003721	This CD includes PGM2 (phosphoglucomutase 2) and PGM2L1 (phosphoglucomutase 2-like 1). The mammalian PGM2 is thought to be a phosphopentomutase that catalyzes the conversion of the nucleoside breakdown products, ribose-1-phosphate and...; Region: PGM2; cd05799
929506003722	active site
929506003723	substrate binding site [chemical binding]; other site
929506003724	metal binding site [ion binding]; metal-binding site
929506003725	Tetratricopeptide repeat; Region: TPR_12; pfam13424
929506003726	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
929506003727	binding surface
929506003728	TPR motif; other site
929506003729	Prokaryotic UGPase catalyses the synthesis of UDP-glucose; Region: UGPase_prokaryotic; cd02541
929506003730	dTDP-glucose pyrophosphorylase [Cell envelope biogenesis, outer membrane]; Region: RfbA; COG1209
929506003731	active site
929506003732	tetramer interface; other site
929506003733	Predicted nucleoside-diphosphate sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: COG1086
929506003734	Left-handed parallel beta-Helix (LbetaH or LbH) domain: The alignment contains 5 turns, each containing three imperfect tandem repeats of a hexapeptide repeat motif (X-[STAV]-X-[LIV]-[GAED]-X). Proteins containing hexapeptide repeats are often enzymes...; Region: LbetaH; cl00160
929506003735	UDP-Glcnac (UDP-linked N-acetylglucosamine) inverting 4,6-dehydratase, extended (e) SDRs; Region: UDP_invert_4-6DH_SDR_e; cd05237
929506003736	NAD(P) binding site [chemical binding]; other site
929506003737	homodimer interface [polypeptide binding]; other site
929506003738	substrate binding site [chemical binding]; other site
929506003739	active site
929506003740	UDP-N-acetyl-D-mannosaminuronate dehydrogenase [Cell envelope biogenesis, outer membrane]; Region: WecC; COG0677
929506003741	UDP-glucose/GDP-mannose dehydrogenase family, central domain; Region: UDPG_MGDP_dh; pfam00984
929506003742	UDP binding domain; Region: UDPG_MGDP_dh_C; smart00984
929506003743	Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673
929506003744	Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408
929506003745	Oxidoreductase family, C-terminal alpha/beta domain; Region: GFO_IDH_MocA_C; pfam02894
929506003746	Left-handed parallel beta-Helix (LbetaH or LbH) domain: The alignment contains 5 turns, each containing three imperfect tandem repeats of a hexapeptide repeat motif (X-[STAV]-X-[LIV]-[GAED]-X). Proteins containing hexapeptide repeats are often enzymes...; Region: LbetaH; cl00160
929506003747	putative trimer interface [polypeptide binding]; other site
929506003748	putative CoA binding site [chemical binding]; other site
929506003749	WcxM-like, Left-handed parallel beta-Helix (LbH) N-terminal domain: This group is composed of Xanthomonas campestris WcxM and proteins with similarity to the WcxM N-terminal domain. WcxM is thought to be bifunctional, catalyzing both the isomerization...; Region: LbH_WxcM_N_like; cd03358
929506003750	putative trimer interface [polypeptide binding]; other site
929506003751	putative active site [active]
929506003752	putative substrate binding site [chemical binding]; other site
929506003753	putative CoA binding site [chemical binding]; other site
929506003754	CMP-NeuAc_Synthase activates N-acetylneuraminic acid by adding CMP moiety; Region: CMP-NeuAc_Synthase; cd02513
929506003755	ligand binding site; other site
929506003756	tetramer interface; other site
929506003757	N-acetylneuraminate synthase; Region: NeuB_NnaB; TIGR03569
929506003758	NeuB family; Region: NeuB; pfam03102
929506003759	C-terminal SAF domain of sialic acid synthetase; Region: SAF_NeuB_like; cd11615
929506003760	NeuB binding interface [polypeptide binding]; other site
929506003761	putative substrate binding site [chemical binding]; other site
929506003762	UDP-N-acetyl-D-glucosamine 2-epimerase, UDP-hydrolysing; Region: NeuC_NnaA; TIGR03568
929506003763	Bacterial members of the UDP-N-Acetylglucosamine (GlcNAc) 2-Epimerase  family are known to catalyze the reversible interconversion of UDP-GlcNAc and UDP-N-acetylmannosamine (UDP-ManNAc). The enzyme serves to produce an activated form of ManNAc residues; Region: GT1_UDP-GlcNAc_2-Epimerase; cd03786
929506003764	active site
929506003765	homodimer interface [polypeptide binding]; other site
929506003766	Putative Acyltransferase (AT), Left-handed parallel beta-Helix (LbH) domain; This group is composed of mostly uncharacterized proteins containing an N-terminal helical subdomain followed by a LbH domain. The alignment contains 6 turns, each containing...; Region: LbH_AT_putative; cd03360
929506003767	sugar O-acyltransferase, sialic acid O-acetyltransferase NeuD family; Region: NeuD_NnaD; TIGR03570
929506003768	putative trimer interface [polypeptide binding]; other site
929506003769	putative CoA binding site [chemical binding]; other site
929506003770	FOG: CBS domain [General function prediction only]; Region: COG0517
929506003771	This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domain associated with the NTP (Nucleotidyl transferase) domain downstream. CBS is a small domain originally identified in cystathionine beta-synthase and subsequently...; Region: CBS_pair_NTP_transferase_assoc; cd04607
929506003772	NTP_trnasferase_like_2 is a member of the nucleotidyl transferase family; Region: NTP_transferase_like_2; cd06426
929506003773	Nucleoside-diphosphate-sugar pyrophosphorylase involved in lipopolysaccharide biosynthesis/translation initiation factor 2B, gamma/epsilon subunits (eIF-2Bgamma/eIF-2Bepsilon) [Cell envelope biogenesis, outer membrane / Translation, ribosomal structure...; Region: GCD1; COG1208
929506003774	Substrate binding site; other site
929506003775	metal-binding site
929506003776	Arna decarboxylase_like, extended (e) SDRs; Region: Arna_like_SDR_e; cd05257
929506003777	NAD dependent epimerase/dehydratase, LLPSF_EDH_00030 family; Region: EDH_00030; TIGR04180
929506003778	NAD binding site [chemical binding]; other site
929506003779	substrate binding site [chemical binding]; other site
929506003780	active site
929506003781	aminotransferase, LLPSF_NHT_00031 family; Region: NHT_00031; TIGR04181
929506003782	3-amino-5-hydroxybenzoic acid synthase family (AHBA_syn). AHBA_syn family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The members of this CD are involved in various biosynthetic pathways for secondary...; Region: AHBA_syn; cd00616
929506003783	inhibitor-cofactor binding pocket; inhibition site
929506003784	pyridoxal 5'-phosphate binding site [chemical binding]; other site
929506003785	catalytic residue [active]
929506003786	InsA N-terminal domain; Region: Zn_Tnp_IS1; pfam03811
929506003787	DDE domain; Region: DDE_Tnp_IS240; pfam13610
929506003788	Integrase core domain; Region: rve; pfam00665
929506003789	Integrase core domain; Region: rve_3; pfam13683
929506003790	Uncharacterized membrane protein, putative virulence factor [General function prediction only]; Region: MviN; COG0728
929506003791	MurJ/MviN, a subfamily of the multidrug and toxic compound extrusion (MATE)-like proteins; Region: MATE_MurJ_like; cd13123
929506003792	Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438
929506003793	Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013
929506003794	This family is most closely related to the GT1 family of glycosyltransferases. wlbH in Bordetella parapertussis has been shown to be required for the biosynthesis of a trisaccharide that, when attached to the B. pertussis lipopolysaccharide (LPS) core; Region: GT1_wlbH_like; cd03798
929506003795	Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438
929506003796	Capsule polysaccharide biosynthesis protein; Region: Capsule_synth; pfam05159
929506003797	ExoA is involved in the biosynthesis of succinoglycan; Region: Succinoglycan_BP_ExoA; cd02525
929506003798	Glycosyltransferase like family 2; Region: Glyco_tranf_2_3; pfam13641
929506003799	Ligand binding site; other site
929506003800	O-Antigen ligase; Region: Wzy_C; cl04850
929506003801	Lipid A core - O-antigen ligase and related enzymes [Cell envelope biogenesis, outer membrane]; Region: RfaL; COG3307
929506003802	Bacterial sugar transferase; Region: Bac_transf; pfam02397
929506003803	Teichoic acid biosynthesis proteins [Cell envelope biogenesis, outer membrane]; Region: WecG; COG1922
929506003804	The glycosyltransferase WecG/TagA superfamily contains Escherichia coli WecG, Bacillus subtilis TagA and related proteins. E. coli WecG is believed to be a UDP-N-acetyl-D-mannosaminuronic acid transferase, and is involved in enterobacterial common...; Region: Glyco_transf_WecG_TagA; cd06533
929506003805	Membrane protein involved in the export of O-antigen and teichoic acid [General function prediction only]; Region: RfbX; COG2244
929506003806	Wzx, a subfamily of the multidrug and toxic compound extrusion (MATE)-like proteins; Region: MATE_Wzx_like; cd13128
929506003807	Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438
929506003808	This family is most closely related to the GT1 family of glycosyltransferases and named after YqgM in Bacillus licheniformis about which little is known. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to...; Region: GT1_YqgM_like; cd03801
929506003809	Proteins of this family catalyze the reduction of flavin or nitrocompounds using NAD(P)H as electron donor in a obligatory two-electron transfer,  utilizing FMN or FAD as cofactor. They are often found to be homodimers. Enzymes of this family are...; Region: Nitro_FMN_reductase; cl00514
929506003810	FMN binding site [chemical binding]; other site
929506003811	dimer interface [polypeptide binding]; other site
929506003812	Formiminotransferase-cyclodeaminase; Region: FTCD_C; pfam04961
929506003813	Methyltransferase domain; Region: Methyltransf_26; pfam13659
929506003814	TaqI-like C-terminal specificity domain; Region: TaqI_C; pfam12950
929506003815	Sulphate Transporter and Anti-Sigma factor antagonist) domain of anti-anti-sigma factors, key regulators of anti-sigma factors by phosphorylation; Region: STAS_anti-anti-sigma_factors; cd07043
929506003816	Sulfate permease and related transporters (MFS superfamily) [Inorganic ion transport and metabolism]; Region: SUL1; COG0659
929506003817	anti sigma factor interaction site; other site
929506003818	regulatory phosphorylation site [posttranslational modification]; other site
929506003819	anti-sigma F factor; Provisional; Region: PRK03660
929506003820	Anti-sigma regulatory factor (Ser/Thr protein kinase) [Signal transduction mechanisms]; Region: RsbW; COG2172
929506003821	sporulation sigma factor SigF; Validated; Region: PRK05572
929506003822	Sigma-70 region 2; Region: Sigma70_r2; pfam04542
929506003823	Sigma-70 region 3; Region: Sigma70_r3; pfam04539
929506003824	Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171
929506003825	DNA binding residues [nucleotide binding]
929506003826	transposase/IS protein; Provisional; Region: PRK09183
929506003827	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
929506003828	Walker A motif; other site
929506003829	ATP binding site [chemical binding]; other site
929506003830	Walker B motif; other site
929506003831	arginine finger; other site
929506003832	Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392
929506003833	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG4584
929506003834	DNA binding site [nucleotide binding]
929506003835	Integrase core domain; Region: rve; pfam00665
929506003836	Retron-type reverse transcriptase [DNA replication, recombination, and repair]; Region: COG3344
929506003837	RT_G2_intron: Reverse transcriptases (RTs) with group II intron origin. RT transcribes DNA using RNA as template. Proteins in this subfamily are found in bacterial and mitochondrial group II introns. Their most probable ancestor was a retrotransposable...; Region: RT_G2_intron; cd01651
929506003838	putative active site [active]
929506003839	putative NTP binding site [chemical binding]; other site
929506003840	putative nucleic acid binding site [nucleotide binding]; other site
929506003841	Reverse transcriptase (RNA-dependent DNA polymerase); Region: RVT_1; pfam00078
929506003842	RT_like: Reverse transcriptase (RT, RNA-dependent DNA polymerase)_like family. An RT gene is usually indicative of a mobile element such as a retrotransposon or retrovirus. RTs occur in a variety of mobile elements, including retrotransposons; Region: RT_like; cl02808
929506003843	Group II intron, maturase-specific domain; Region: GIIM; pfam08388
929506003844	stage V sporulation protein AC; Region: spore_V_AC; TIGR02838
929506003845	stage V sporulation protein AD; Validated; Region: PRK08304
929506003846	stage V sporulation protein AD; Provisional; Region: PRK12404
929506003847	stage V sporulation protein AE; Region: spore_V_AE; TIGR02839
929506003848	Transglycosylase; Region: Transgly; pfam00912
929506003849	penicillin-binding protein, 1A family; Region: PBP_1a_fam; TIGR02074
929506003850	Penicillin binding protein transpeptidase domain; Region: Transpeptidase; cl17760
929506003851	Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223
929506003852	active site
929506003853	GTP-binding protein HflX; Region: GTP_HflX; TIGR03156
929506003854	GTP-binding GTPase N-terminal; Region: GTP-bdg_N; pfam13167
929506003855	HflX GTPase family; Region: HflX; cd01878
929506003856	G1 box; other site
929506003857	GTP/Mg2+ binding site [chemical binding]; other site
929506003858	Switch I region; other site
929506003859	G2 box; other site
929506003860	G3 box; other site
929506003861	Switch II region; other site
929506003862	G4 box; other site
929506003863	G5 box; other site
929506003864	TRZ/ATZ family contains enzymes from the atrazine degradation pathway and related hydrolases. Atrazine, a chlorinated herbizide, can be catabolized by a variety of different bacteria. The first three steps of the atrazine dehalogenation pathway are...; Region: ATZ_TRZ_like; cd01298
929506003865	N-ethylammeline chlorohydrolase; Provisional; Region: PRK06038
929506003866	active site
929506003867	putative substrate binding pocket [chemical binding]; other site
929506003868	Nucleotidyltransferase (NT) domain of Staphylococcus aureus kanamycin nucleotidyltransferase, and similar proteins; Region: NT_KNTase_like; cd05403
929506003869	active site
929506003870	NTP binding site [chemical binding]; other site
929506003871	metal binding triad [ion binding]; metal-binding site
929506003872	antibiotic binding site [chemical binding]; other site
929506003873	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain (MocR family) and their eukaryotic orthologs [Transcription / Amino acid transport and metabolism]; Region: ARO8; COG1167
929506003874	Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377
929506003875	DNA-binding site [nucleotide binding]; DNA binding site
929506003876	Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609
929506003877	pyridoxal 5'-phosphate binding site [chemical binding]; other site
929506003878	homodimer interface [polypeptide binding]; other site
929506003879	catalytic residue [active]
929506003880	FOG: HEAT repeat [Energy production and conversion]; Region: COG1413
929506003881	Uncharacterized conserved protein [Function unknown]; Region: COG1739
929506003882	Uncharacterized protein family UPF0029; Region: UPF0029; pfam01205
929506003883	Domain of unknown function (DUF1949); Region: DUF1949; pfam09186
929506003884	hypothetical protein; Validated; Region: PRK00110
929506003885	Trypsin-like peptidase domain; Region: Trypsin_2; pfam13365
929506003886	Trypsin-like peptidase domain; Region: Trypsin_2; pfam13365
929506003887	Trypsin-like serine protease; Many of these are synthesized as inactive precursor zymogens that are cleaved during limited proteolysis to generate their active forms. Alignment contains also inactive enzymes that have substitutions of the catalytic triad...; Region: Tryp_SPc; cl00149
929506003888	H+/gluconate symporter and related permeases [Carbohydrate transport and metabolism / Amino acid transport and metabolism]; Region: GntT; COG2610
929506003889	fructuronate transporter; Provisional; Region: PRK10034; cl15264
929506003890	ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132
929506003891	ABC transporter transmembrane region; Region: ABC_membrane; pfam00664
929506003892	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
929506003893	Walker A/P-loop; other site
929506003894	ATP binding site [chemical binding]; other site
929506003895	Q-loop/lid; other site
929506003896	ABC transporter signature motif; other site
929506003897	Walker B; other site
929506003898	D-loop; other site
929506003899	H-loop/switch region; other site
929506003900	ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132
929506003901	ABC transporter transmembrane region; Region: ABC_membrane; pfam00664
929506003902	ATP-binding cassette domain of glucan transporter and related proteins, subfamily C; Region: ABCC_Glucan_exporter_like; cd03254
929506003903	Walker A/P-loop; other site
929506003904	ATP binding site [chemical binding]; other site
929506003905	Q-loop/lid; other site
929506003906	ABC transporter signature motif; other site
929506003907	Walker B; other site
929506003908	D-loop; other site
929506003909	H-loop/switch region; other site
929506003910	Sporulation protein YtfJ (Spore_YtfJ); Region: Spore_YtfJ; pfam09579
929506003911	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3314
929506003912	Nucleoside recognition; Region: Gate; pfam07670
929506003913	InsA N-terminal domain; Region: Zn_Tnp_IS1; pfam03811
929506003914	DDE domain; Region: DDE_Tnp_IS240; pfam13610
929506003915	Integrase core domain; Region: rve; pfam00665
929506003916	Integrase core domain; Region: rve_3; pfam13683
929506003917	TspO/MBR family; Region: TspO_MBR; pfam03073
929506003918	Uncharacterized conserved protein [Function unknown]; Region: COG1633
929506003919	Ferritin-like superfamily of diiron-containing four-helix-bundle proteins; Region: Ferritin_like; cd00657
929506003920	dinuclear metal binding motif [ion binding]; other site
929506003921	Holliday junction DNA helicase RuvA; Reviewed; Region: ruvA; PRK00116
929506003922	RuvA N terminal domain; Region: RuvA_N; pfam01330
929506003923	RuvA, C-terminal domain; Region: RuvA_C; pfam07499
929506003924	Holliday junction DNA helicase RuvB; Reviewed; Region: ruvB; PRK00080
929506003925	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
929506003926	Walker A motif; other site
929506003927	ATP binding site [chemical binding]; other site
929506003928	Walker B motif; other site
929506003929	arginine finger; other site
929506003930	Holliday junction DNA helicase ruvB C-terminus; Region: RuvB_C; pfam05491
929506003931	S-adenosylmethionine:tRNA ribosyltransferase-isomerase; Provisional; Region: queA; PRK00147
929506003932	S-adenosylmethionine:tRNA ribosyltransferase-isomerase; Region: queA; TIGR00113
929506003933	queuine tRNA-ribosyltransferase; Provisional; Region: tgt; PRK00112
929506003934	Queuine/archaeosine tRNA-ribosyltransferase [Translation, ribosomal structure and biogenesis]; Region: Tgt; COG0343
929506003935	preprotein translocase subunit YajC; Validated; Region: yajC; PRK05585
929506003936	putative membrane protein, TIGR04086 family; Region: TIGR04086_membr
929506003937	Protein of unknown function (DUF4001); Region: DUF4001; cl14848
929506003938	SCIFF radical SAM maturase; Region: rSAM_six_Cys; TIGR03974
929506003939	Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335
929506003940	FeS/SAM binding site; other site
929506003941	radical SAM additional 4Fe4S-binding SPASM domain; Region: rSAM_more_4Fe4S; TIGR04085
929506003942	protein-export membrane protein SecD; Region: secD; TIGR01129
929506003943	protein-export membrane protein, SecD/SecF family; Region: 2A0604s01; TIGR00916
929506003944	preprotein translocase subunit SecF; Reviewed; Region: secF; PRK13022
929506003945	SecD/SecF GG Motif; Region: Sec_GG; pfam07549
929506003946	Protein export membrane protein; Region: SecD_SecF; pfam02355
929506003947	DHH family; Region: DHH; pfam01368
929506003948	Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223
929506003949	active site
929506003950	Guanosine polyphosphate pyrophosphohydrolases/synthetases [Signal transduction mechanisms / Transcription]; Region: SpoT; COG0317
929506003951	Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077
929506003952	Zn2+ binding site [ion binding]; other site
929506003953	Mg2+ binding site [ion binding]; other site
929506003954	Nucleotidyltransferase (NT) domain of RelA- and SpoT-like ppGpp synthetases and hydrolases; Region: NT_Rel-Spo_like; cd05399
929506003955	synthetase active site [active]
929506003956	NTP binding site [chemical binding]; other site
929506003957	metal binding site [ion binding]; metal-binding site
929506003958	TGS_RelA_SpoT: The RelA (SpoT) protein, also referred to as ppGpp hydrolase/synthetase, is a ribosome-associated protein that is activated during amino acid starvation and thought to mediate the stringent response. RelA contains a TGS domain, named after...; Region: TGS_RelA_SpoT; cd01668
929506003959	ACT  domain found C-terminal of the RelA/SpoT domains; Region: ACT_RelA-SpoT; cd04876
929506003960	D-Tyrosyl-tRNAtyr deacylases; a class of tRNA-dependent hydrolases which are capable of hydrolyzing the ester bond of D-Tyrosyl-tRNA reducing the level of cellular D-Tyrosine while recycling the peptidyl-tRNA; found in bacteria and in eukaryotes but not...; Region: Dtyr_deacylase; cd00563
929506003961	putative active site [active]
929506003962	dimerization interface [polypeptide binding]; other site
929506003963	putative tRNAtyr binding site [nucleotide binding]; other site
929506003964	Metallo-beta-lactamase superfamily; Region: Lactamase_B; smart00849
929506003965	coproporphyrinogen III oxidase; Provisional; Region: PRK08207
929506003966	Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335
929506003967	FeS/SAM binding site; other site
929506003968	histidyl-tRNA synthetase; Reviewed; Region: hisS; PRK00037
929506003969	Class II Histidinyl-tRNA synthetase (HisRS)-like catalytic core domain. HisRS is a homodimer. It is responsible for the attachment of histidine to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for...; Region: HisRS-like_core; cd00773
929506003970	dimer interface [polypeptide binding]; other site
929506003971	motif 1; other site
929506003972	active site
929506003973	motif 2; other site
929506003974	motif 3; other site
929506003975	HisRS Histidyl-anticodon binding domain. HisRS belongs to class II aminoacyl-tRNA synthetases (aaRS). This alignment contains the anticodon binding domain, which is responsible for specificity in tRNA-binding, so that the activated amino acid is...; Region: HisRS_anticodon; cd00859
929506003976	anticodon binding site; other site
929506003977	aspartyl-tRNA synthetase; Validated; Region: aspS; PRK00476
929506003978	EcAspRS_like_N: N-terminal, anticodon recognition domain of the type found in Escherichia coli aspartyl-tRNA synthetase (AspRS), the human mitochondrial (mt) AspRS-2, the discriminating (D) Thermus thermophilus AspRS-1, and the nondiscriminating (ND)...; Region: EcAspRS_like_N; cd04317
929506003979	dimer interface [polypeptide binding]; other site
929506003980	anticodon binding site; other site
929506003981	Asp tRNA synthetase (aspRS) class II core domain. Class II assignment is based upon its structure and the presence of three characteristic sequence motifs. AspRS is a homodimer, which attaches a specific amino acid to the 3' OH group of ribose of...; Region: AspRS_core; cd00777
929506003982	homodimer interface [polypeptide binding]; other site
929506003983	motif 1; other site
929506003984	active site
929506003985	motif 2; other site
929506003986	GAD domain; Region: GAD; pfam02938
929506003987	Asp tRNA synthetase (aspRS) class II core domain. Class II assignment is based upon its structure and the presence of three characteristic sequence motifs. AspRS is a homodimer, which attaches a specific amino acid to the 3' OH group of ribose of...; Region: AspRS_core; cd00777
929506003988	motif 3; other site
929506003989	Transcriptional regulators CsoR (copper-sensitive operon repressor), RcnR, and FrmR, and related domains; this domain superfamily was previously known as DUF156; Region: CsoR-like_DUF156; cd10148
929506003990	putative homodimer interface [polypeptide binding]; other site
929506003991	putative homotetramer interface [polypeptide binding]; other site
929506003992	putative allosteric switch controlling residues; other site
929506003993	putative metal binding site [ion binding]; other site
929506003994	putative homodimer-homodimer interface [polypeptide binding]; other site
929506003995	Protein of unknown function (DUF3815); Region: DUF3815; pfam12821
929506003996	Uncharacterized conserved protein [Function unknown]; Region: COG2966
929506003997	Protein of unknown function (DUF1212); Region: DUF1212; pfam06738
929506003998	Protein of unknown function (DUF3815); Region: DUF3815; cl01118
929506003999	serine hydroxymethyltransferase; Reviewed; Region: glyA; PRK00011
929506004000	Serine-glycine hydroxymethyltransferase (SHMT). This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). SHMT carries out interconversion of serine and glycine; it catalyzes the transfer of hydroxymethyl...; Region: SHMT; cd00378
929506004001	dimer interface [polypeptide binding]; other site
929506004002	active site
929506004003	glycine-pyridoxal phosphate binding site [chemical binding]; other site
929506004004	folate binding site [chemical binding]; other site
929506004005	pyruvate:ferredoxin (flavodoxin) oxidoreductase, homodimeric; Region: pyruv_ox_red; TIGR02176
929506004006	Pyrimidine (PYR) binding domain of pyruvate ferredoxin oxidoreductase (PFOR), indolepyruvate ferredoxin oxidoreductase alpha subunit (IOR-alpha), and related proteins; Region: TPP_PYR_PFOR_IOR-alpha_like; cd07034
929506004007	dimer interface [polypeptide binding]; other site
929506004008	PYR/PP interface [polypeptide binding]; other site
929506004009	TPP binding site [chemical binding]; other site
929506004010	substrate binding site [chemical binding]; other site
929506004011	Pyruvate:ferredoxin oxidoreductase and related 2-oxoacid:ferredoxin oxidoreductases, gamma subunit [Energy production and conversion]; Region: PorG; COG1014
929506004012	Domain of unknown function; Region: EKR; pfam10371
929506004013	4Fe-4S binding domain; Region: Fer4_6; pfam12837
929506004014	4Fe-4S binding domain; Region: Fer4; pfam00037
929506004015	Thiamine pyrophosphate (TPP family), PFOR_PNO subfamily, TPP-binding module; composed of proteins similar to the single subunit pyruvate ferredoxin oxidoreductase (PFOR) of Desulfovibrio Africanus, present in bacteria and amitochondriate eukaryotes. This...; Region: TPP_PFOR_PNO; cd03377
929506004016	TPP-binding site [chemical binding]; other site
929506004017	dimer interface [polypeptide binding]; other site
929506004018	Protein of unknown function (DUF1292); Region: DUF1292; pfam06949
929506004019	haloacid dehalogenase-like hydrolase; Region: Hydrolase; pfam00702
929506004020	Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427
929506004021	motif II; other site
929506004022	PyridoxaL 5'-Phosphate Dependent Enzymes class IV (PLPDE_IV). This D-amino acid superfamily, one of five classes of PLPDE, consists of branched-chain amino acid aminotransferases (BCAT), D-amino acid transferases (DAAT), and...; Region: PLPDE_IV; cd00449
929506004023	homodimer interface [polypeptide binding]; other site
929506004024	Branched-chain amino acid aminotransferase/4-amino-4-deoxychorismate lyase [Amino acid transport and metabolism / Coenzyme metabolism]; Region: IlvE; COG0115
929506004025	substrate-cofactor binding pocket; other site
929506004026	pyridoxal 5'-phosphate binding site [chemical binding]; other site
929506004027	catalytic residue [active]
929506004028	Zinc dependent phospholipase C (alpha toxin); Region: Zn_dep_PLPC; cd11009
929506004029	Zn binding site [ion binding]; other site
929506004030	PLAT/LH2 domain; Region: PLAT; pfam01477
929506004031	PTS system, glucose-specific IIBC component; Region: PTS-II-BC-glcB; TIGR02002
929506004032	Phosphotransferase system IIC components, glucose/maltose/N-acetylglucosamine-specific [Carbohydrate transport and metabolism]; Region: PtsG; COG1263
929506004033	PTS_IIB, PTS system, glucose/sucrose specific IIB subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIB_glc; cd00212
929506004034	active site turn [active]
929506004035	phosphorylation site [posttranslational modification]
929506004036	Phosphotransferase system IIA components [Carbohydrate transport and metabolism]; Region: NagE; COG2190
929506004037	HPr interaction site; other site
929506004038	glycerol kinase (GK) interaction site [polypeptide binding]; other site
929506004039	active site
929506004040	phosphorylation site [posttranslational modification]
929506004041	Uncharacterized conserved protein [Function unknown]; Region: COG1315
929506004042	CheW-like domain. CheW proteins are part of the chemotaxis signalling mechanism in bacteria. CheW interacts with the methyl accepting chemotaxis proteins (MCPs) and relays signals to CheY, which affects flageller rotation. This family includes CheW and...; Region: CheW_like; cl00256
929506004043	chemoreceptor glutamine deamidase CheD; Provisional; Region: PRK13490
929506004044	chemotaxis-specific methylesterase; Provisional; Region: PRK00742
929506004045	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
929506004046	active site
929506004047	phosphorylation site [posttranslational modification]
929506004048	intermolecular recognition site; other site
929506004049	dimerization interface [polypeptide binding]; other site
929506004050	CheB methylesterase; Region: CheB_methylest; pfam01339
929506004051	Methylase of chemotaxis methyl-accepting proteins [Cell motility and secretion / Signal transduction mechanisms]; Region: CheR; COG1352
929506004052	CheR methyltransferase, all-alpha domain; Region: CheR_N; pfam03705
929506004053	CheR methyltransferase, SAM binding domain; Region: CheR; pfam01739
929506004054	Histidine Phosphotransfer domain, involved in signalling through a two part component systems in which an autophosphorylating histidine protein kinase serves as a phosphoryl donor to a response regulator protein; the response regulator protein is...; Region: HPT; cd00088
929506004055	putative binding surface; other site
929506004056	active site
929506004057	P2 response regulator binding domain; Region: P2; pfam07194
929506004058	Chemotaxis protein histidine kinase and related kinases [Cell motility and secretion / Signal transduction mechanisms]; Region: CheA; COG0643
929506004059	Signal transducing histidine kinase, homodimeric domain; Region: H-kinase_dim; pfam02895
929506004060	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
929506004061	ATP binding site [chemical binding]; other site
929506004062	Mg2+ binding site [ion binding]; other site
929506004063	G-X-G motif; other site
929506004064	CheW-like domain. CheW proteins are part of the chemotaxis signalling mechanism in bacteria. CheW interacts with the methyl accepting chemotaxis proteins (MCPs) and relays signals to CheY, which affects flageller rotation. This family includes CheW and...; Region: CheW_like; cl00256
929506004065	Chemotaxis protein CheC, inhibitor of MCP methylation [Cell motility and secretion / Signal transduction mechanisms]; Region: CheC; COG1776
929506004066	CheC-like family; Region: CheC; pfam04509
929506004067	CheC-like family; Region: CheC; pfam04509
929506004068	FOG: CheY-like receiver [Signal transduction mechanisms]; Region: CheY; COG0784
929506004069	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
929506004070	active site
929506004071	phosphorylation site [posttranslational modification]
929506004072	intermolecular recognition site; other site
929506004073	dimerization interface [polypeptide binding]; other site
929506004074	CheW-like domain; Region: CheW; pfam01584
929506004075	flagellar motor switch protein FliM; Validated; Region: fliM; PRK06666
929506004076	Surface presentation of antigens (SPOA); Region: SpoA; pfam01052
929506004077	flagellar motor switch protein; Validated; Region: PRK08119
929506004078	CheC-like family; Region: CheC; pfam04509
929506004079	CheC-like family; Region: CheC; pfam04509
929506004080	flagellar motor switch protein FliN; Region: fliN; TIGR02480
929506004081	flagellar biosynthesis anti-sigma factor FlgM; Region: FlgM_jcvi; TIGR03824
929506004082	FlgN protein; Region: FlgN; pfam05130
929506004083	Flagella basal body rod protein; Region: Flg_bb_rod; pfam00460
929506004084	Flagellar basal body rod FlgEFG protein C-terminal; Region: Flg_bbr_C; pfam06429
929506004085	Bacterial flagellin N-terminal helical region; Region: Flagellin_N; pfam00669
929506004086	Bacterial flagellin C-terminal helical region; Region: Flagellin_C; pfam00700
929506004087	flagellar assembly protein FliW; Provisional; Region: PRK13285
929506004088	Global regulator protein family; Region: CsrA; pfam02599
929506004089	FlaG protein; Region: FlaG; pfam03646
929506004090	Flagellar protein FliS; Region: FliS; cl00654
929506004091	Flagellar hook-associated protein 2 C-terminus; Region: FliD_N; pfam02465
929506004092	Flagellar hook-associated protein 2 C-terminus; Region: FliD_C; pfam07195
929506004093	flagellin; Provisional; Region: PRK12804
929506004094	Bacterial flagellin N-terminal helical region; Region: Flagellin_N; pfam00669
929506004095	Bacterial flagellin C-terminal helical region; Region: Flagellin_C; pfam00700
929506004096	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2604
929506004097	This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domain associated with the NTP (Nucleotidyl transferase) domain downstream. CBS is a small domain originally identified in cystathionine beta-synthase and subsequently...; Region: CBS_pair_NTP_transferase_assoc; cd04607
929506004098	Nucleoside-diphosphate-sugar pyrophosphorylase involved in lipopolysaccharide biosynthesis/translation initiation factor 2B, gamma/epsilon subunits (eIF-2Bgamma/eIF-2Bepsilon) [Cell envelope biogenesis, outer membrane / Translation, ribosomal structure...; Region: GCD1; COG1208
929506004099	NTP_trnasferase_like_2 is a member of the nucleotidyl transferase family; Region: NTP_transferase_like_2; cd06426
929506004100	Substrate binding site; other site
929506004101	metal-binding site
929506004102	UDP-N-acetyl-D-glucosamine 2-epimerase, UDP-hydrolysing; Region: NeuC_NnaA; TIGR03568
929506004103	Bacterial members of the UDP-N-Acetylglucosamine (GlcNAc) 2-Epimerase  family are known to catalyze the reversible interconversion of UDP-GlcNAc and UDP-N-acetylmannosamine (UDP-ManNAc). The enzyme serves to produce an activated form of ManNAc residues; Region: GT1_UDP-GlcNAc_2-Epimerase; cd03786
929506004104	active site
929506004105	homodimer interface [polypeptide binding]; other site
929506004106	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
929506004107	S-adenosylmethionine binding site [chemical binding]; other site
929506004108	N-acetylneuraminate synthase; Region: NeuB_NnaB; TIGR03569
929506004109	NeuB family; Region: NeuB; pfam03102
929506004110	C-terminal SAF domain of sialic acid synthetase; Region: SAF_NeuB_like; cd11615
929506004111	NeuB binding interface [polypeptide binding]; other site
929506004112	putative substrate binding site [chemical binding]; other site
929506004113	carbamoyl phosphate synthase-like protein; Provisional; Region: PRK12767
929506004114	carbamoyl phosphate synthase-like protein; Provisional; Region: PRK12767
929506004115	ATP-grasp domain; Region: ATP-grasp_4; pfam13535
929506004116	CMP-NeuAc_Synthase activates N-acetylneuraminic acid by adding CMP moiety; Region: CMP-NeuAc_Synthase; cd02513
929506004117	ligand binding site; other site
929506004118	tetramer interface; other site
929506004119	GlcNAc-PI de-N-acetylase; Region: PIG-L; cl00929
929506004120	Arna decarboxylase_like, extended (e) SDRs; Region: Arna_like_SDR_e; cd05257
929506004121	NAD dependent epimerase/dehydratase, LLPSF_EDH_00030 family; Region: EDH_00030; TIGR04180
929506004122	NAD binding site [chemical binding]; other site
929506004123	substrate binding site [chemical binding]; other site
929506004124	active site
929506004125	sodium/calcium exchanger 1; Region: caca; TIGR00845
929506004126	Nucleoside-diphosphate-sugar pyrophosphorylase involved in lipopolysaccharide biosynthesis/translation initiation factor 2B, gamma/epsilon subunits (eIF-2Bgamma/eIF-2Bepsilon) [Cell envelope biogenesis, outer membrane / Translation, ribosomal structure...; Region: GCD1; COG1208
929506004127	Phosphocholine cytidylyltransferases catalyze the synthesis of CDP-choline; Region: PC_cytidylyltransferase; cd02523
929506004128	active site
929506004129	metal-binding site
929506004130	Choline Kinase (ChoK). The ChoK subfamily is part of a larger superfamily that includes the catalytic domains of other kinases, such as the typical serine/threonine/tyrosine protein kinases (PKs), RIO kinases, actin-fragmin kinase (AFK), and...; Region: ChoK; cd05151
929506004131	active site
929506004132	ATP binding site [chemical binding]; other site
929506004133	Phosphotransferase enzyme family; Region: APH; pfam01636
929506004134	substrate binding site [chemical binding]; other site
929506004135	dimer interface [polypeptide binding]; other site
929506004136	Sulfatase; Region: Sulfatase; cl17466
929506004137	EamA-like transporter family; Region: EamA; pfam00892
929506004138	Carboxylate/Amino Acid/Amine Transporter; Region: 2A78; TIGR00950
929506004139	flagellin; Provisional; Region: PRK12804
929506004140	Bacterial flagellin N-terminal helical region; Region: Flagellin_N; pfam00669
929506004141	Bacterial flagellin C-terminal helical region; Region: Flagellin_C; pfam00700
929506004142	Bacterial flagellin N-terminal helical region; Region: Flagellin_N; pfam00669
929506004143	flagellin; Provisional; Region: PRK12804
929506004144	Bacterial flagellin C-terminal helical region; Region: Flagellin_C; pfam00700
929506004145	flagellar basal body rod protein FlgB; Provisional; Region: flgB; PRK12623
929506004146	flagellar basal body rod protein FlgC; Provisional; Region: flgC; PRK12630
929506004147	Flagella basal body rod protein; Region: Flg_bb_rod; pfam00460
929506004148	Flagellar basal body rod FlgEFG protein C-terminal; Region: Flg_bbr_C; pfam06429
929506004149	flagellar hook-basal body protein FliE; Provisional; Region: fliE; PRK12728
929506004150	flagellar MS-ring protein; Reviewed; Region: fliF; PRK06007
929506004151	Secretory protein of YscJ/FliF family; Region: YscJ_FliF; cl01907
929506004152	Flagellar M-ring protein C-terminal; Region: YscJ_FliF_C; pfam08345
929506004153	flagellar motor switch protein G; Validated; Region: fliG; PRK05686
929506004154	FliG C-terminal domain; Region: FliG_C; pfam01706
929506004155	Flagellar biosynthesis/type III secretory pathway protein [Cell motility and secretion / Intracellular trafficking and secretion]; Region: FliH; COG1317
929506004156	flagellar protein export ATPase FliI; Region: FliI_clade2; TIGR03497
929506004157	ATP synthase alpha/beta family, beta-barrel domain; Region: ATP-synt_ab_N; pfam02874
929506004158	Flagellum-specific ATPase/type III secretory pathway virulence-related protein. This group of ATPases are responsible for the export of flagellum and virulence-related proteins. The bacterial flagellar motor is similar to the F0F1-ATPase, in that they...; Region: ATPase_flagellum-secretory_path_III; cd01136
929506004159	Walker A motif/ATP binding site; other site
929506004160	Walker B motif; other site
929506004161	flagellar export protein FliJ; Region: flagell_FliJ; TIGR02473
929506004162	Flagellar hook-length control protein FliK; Region: Flg_hook; pfam02120
929506004163	Flagellar hook capping protein - N-terminal region; Region: FlgD; pfam03963
929506004164	flagellar basal body rod modification protein; Provisional; Region: flgD; PRK09618
929506004165	Protein of unknown function (DUF3766); Region: DUF3766; cl11797
929506004166	Flagellar hook protein FlgE [Cell motility and secretion]; Region: FlgE; COG1749
929506004167	Flagella basal body rod protein; Region: Flg_bb_rod; pfam00460
929506004168	Flagellar basal body rod FlgEFG protein C-terminal; Region: Flg_bbr_C; pfam06429
929506004169	Flagellar protein (FlbD); Region: FlbD; pfam06289
929506004170	Flagellar motor component [Cell motility and secretion]; Region: MotA; COG1291
929506004171	MotA/TolQ/ExbB proton channel family; Region: MotA_ExbB; cl00568
929506004172	flagellar motor protein MotB; Reviewed; Region: motB; PRK07734
929506004173	Membrane MotB of proton-channel complex MotA/MotB; Region: MotB_plug; pfam13677
929506004174	Peptidoglycan binding domains similar to the C-terminal domain of outer-membrane protein OmpA; Region: OmpA_C-like; cd07185
929506004175	ligand binding site [chemical binding]; other site
929506004176	Flagellar basal body-associated protein FliL; Region: FliL; pfam03748
929506004177	flagellar biosynthetic protein FliO; Region: FliO_TIGR; TIGR03500
929506004178	flagellar biosynthesis protein FliP; Reviewed; Region: fliP; PRK05699
929506004179	Flagellar biosynthesis pathway, component FliQ [Cell motility and secretion / Intracellular trafficking and secretion]; Region: FliQ; COG1987
929506004180	bifunctional flagellar biosynthesis protein FliR/FlhB; Provisional; Region: PRK12772
929506004181	flagellar biosynthesis protein FliR; Reviewed; Region: fliR; PRK05701
929506004182	Uncharacterized homolog of the cytoplasmic domain of flagellar protein FhlB [Function unknown]; Region: COG2257
929506004183	flagellar biosynthesis protein FlhA; Validated; Region: flhA; PRK06012
929506004184	FHIPEP family; Region: FHIPEP; pfam00771
929506004185	flagellar biosynthesis regulator FlhF; Validated; Region: flhF; PRK05703
929506004186	Circularly permuted YlqF-related GTPases; Region: YlqF_related_GTPase; cl17249
929506004187	GTP/Mg2+ binding site [chemical binding]; other site
929506004188	G5 box; other site
929506004189	The Fer4_NifH superfamily contains a variety of proteins which share a common ATP-binding domain. Functionally, proteins in this superfamily use the energy from hydrolysis of NTP to transfer electron or ion; Region: Fer4_NifH; cl17203
929506004190	G1 box; other site
929506004191	Antiactivator of flagellar biosynthesis FleN, an ATPase [Cell motility]; Region: flhG; COG0455
929506004192	FleN is a member of the Fer4_NifH superfamily. It shares the common function as an ATPase, with the ATP-binding domain at the N-terminus. In Pseudomonas aeruginosa, FleN gene is involved in regulating the number of flagella and chemotactic motility by...; Region: FleN-like; cd02038
929506004193	P-loop; other site
929506004194	Flagellar protein YcgR; Region: YcgR_2; pfam12945
929506004195	c-di-GMP-binding protein [Signal transduction mechanisms]; Region: COG5581
929506004196	PilZ domain; Region: PilZ; pfam07238
929506004197	RNA polymerase sigma factor, FliA/WhiG family; Region: FliA_WhiG; TIGR02479
929506004198	Sigma-70 region 2; Region: Sigma70_r2; pfam04542
929506004199	Sigma-70 region 3; Region: Sigma70_r3; pfam04539
929506004200	Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171
929506004201	DNA binding residues [nucleotide binding]
929506004202	flagellar basal body rod protein FlgG; Reviewed; Region: flgG; PRK12818
929506004203	Flagella basal body rod protein; Region: Flg_bb_rod; pfam00460
929506004204	Flagellar basal body rod FlgEFG protein C-terminal; Region: Flg_bbr_C; pfam06429
929506004205	flagellar basal body rod protein FlgG; Reviewed; Region: flgG; PRK12817
929506004206	Flagella basal body rod protein; Region: Flg_bb_rod; pfam00460
929506004207	Flagellar basal body rod FlgEFG protein C-terminal; Region: Flg_bbr_C; pfam06429
929506004208	putative manganese-dependent inorganic pyrophosphatase; Provisional; Region: PRK14869
929506004209	The CBS domain, named after human CBS, is a small domain originally identified in cystathionine beta-synthase and is subsequently found in a wide range of different proteins. CBS domains usually occur in tandem repeats. They associate to form a so-called...; Region: CBS_pair; cl15354
929506004210	DRTGG domain; Region: DRTGG; pfam07085
929506004211	The CBS domain, named after human CBS, is a small domain originally identified in cystathionine beta-synthase and is subsequently found in a wide range of different proteins. CBS domains usually occur in tandem repeats. They associate to form a so-called...; Region: CBS_pair; cd02205
929506004212	DHHA2 domain; Region: DHHA2; pfam02833
929506004213	Cation transport ATPase [Inorganic ion transport and metabolism]; Region: MgtA; COG0474
929506004214	Cation transporter/ATPase, N-terminus; Region: Cation_ATPase_N; smart00831
929506004215	E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122
929506004216	Putative hydrolase of sodium-potassium ATPase alpha subunit; Region: Hydrolase_like2; pfam13246
929506004217	Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427
929506004218	motif II; other site
929506004219	Cation transporting ATPase, C-terminus; Region: Cation_ATPase_C; pfam00689
929506004220	AAA domain; Region: AAA_32; pfam13654
929506004221	Lon protease (S16) C-terminal proteolytic domain; Region: Lon_C; pfam05362
929506004222	GTP-binding protein YchF; Reviewed; Region: PRK09601
929506004223	YchF GTPase; Region: YchF; cd01900
929506004224	G1 box; other site
929506004225	GTP/Mg2+ binding site [chemical binding]; other site
929506004226	Switch I region; other site
929506004227	G2 box; other site
929506004228	Switch II region; other site
929506004229	G3 box; other site
929506004230	G4 box; other site
929506004231	G5 box; other site
929506004232	TGS_YchF_C: This subfamily represents TGS domain-containing YchF GTP-binding protein, a universally conserved GTPase whose function is unknown. The N-terminal domain of the YchF protein belongs to the Obg-like family of GTPases, and some members of the...; Region: TGS_YchF_C; cd04867
929506004233	MraW methylase family; Region: Methyltransf_5; pfam01795
929506004234	16S rRNA m(4)C1402 methyltranserfase; Provisional; Region: PRK00050
929506004235	stage V sporulation protein D; Region: spoVD_pbp; TIGR02214
929506004236	Penicillin-binding Protein dimerisation domain; Region: PBP_dimer; pfam03717
929506004237	Penicillin binding protein transpeptidase domain; Region: Transpeptidase; pfam00905
929506004238	PASTA domain of PBP2x-like proteins, first repeat. Penicillin-binding proteins (PBPs) are the major targets for beta-lactam antibiotics, like penicillins and cephalosporins. Beta-lactam antibiotics specifically inhibit transpeptidase activity by...; Region: PASTA_Pbp2x-like_1; cd06576
929506004239	PASTA domain of PBP2x-like proteins, second repeat. Penicillin-binding proteins (PBPs) are the major targets for beta-lactam antibiotics, like penicillins and cephalosporins. Beta-lactam antibiotics specifically inhibit transpeptidase activity by...; Region: PASTA_Pbp2x-like_2; cd06575
929506004240	UDP-N-acetylmuramoylalanyl-D-glutamate--2, 6-diaminopimelate ligase; Provisional; Region: murE; PRK00139
929506004241	Mur ligase family, catalytic domain; Region: Mur_ligase; pfam01225
929506004242	Mur ligase middle domain; Region: Mur_ligase_M; pfam08245
929506004243	Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875
929506004244	UDP-N-acetylmuramyl pentapeptide synthase [Cell envelope biogenesis, outer membrane]; Region: MurF; COG0770
929506004245	Mur ligase family, catalytic domain; Region: Mur_ligase; pfam01225
929506004246	Mur ligase middle domain; Region: Mur_ligase_M; pfam08245
929506004247	Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875
929506004248	phospho-N-acetylmuramoyl-pentapeptide-transferase; Provisional; Region: mraY; PRK00108
929506004249	Phospho-N-acetylmuramoyl-pentapeptide-transferase (mraY) is an enzyme responsible for the formation of the first lipid intermediate in the synthesis of bacterial cell wall peptidoglycan. It catalyzes the formation of...; Region: GT_MraY; cd06852
929506004250	Mg++ binding site [ion binding]; other site
929506004251	putative catalytic motif [active]
929506004252	putative substrate binding site [chemical binding]; other site
929506004253	Cell cycle protein; Region: FTSW_RODA_SPOVE; cl00511
929506004254	Cell division septal protein [Cell envelope biogenesis, outer membrane]; Region: FtsQ; COG1589
929506004255	POTRA domain, FtsQ-type; Region: POTRA_1; pfam08478
929506004256	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3879
929506004257	Bacterial protein of unknown function (DUF881); Region: DUF881; pfam05949
929506004258	Protein of unknown function (DUF1290); Region: DUF1290; pfam06947
929506004259	Bacterial protein of unknown function (DUF881); Region: DUF881; pfam05949
929506004260	Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzymes, YBL036c-like proteins; Region: PLPDE_III_YBL036c_like; cd00635
929506004261	pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site
929506004262	catalytic residue [active]
929506004263	Protein of unknown function (DUF552); Region: DUF552; cl00775
929506004264	YGGT family; Region: YGGT; cl00508
929506004265	Uncharacterized conserved protein, contains S4-like domain [Function unknown]; Region: COG2302
929506004266	S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site;  Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165
929506004267	RNA binding surface [nucleotide binding]; other site
929506004268	DivIVA protein; Region: DivIVA; pfam05103
929506004269	DivIVA domain; Region: DivI1A_domain; TIGR03544
929506004270	5'-methylthioadenosine/S-adenosylhomocysteine nucleosidase; Validated; Region: PRK05584
929506004271	5'-methylthioadenosine/S-adenosylhomocysteine nucleosidase; Region: MTA/SAH-Nsdase; TIGR01704
929506004272	Prokaryotic dksA/traR C4-type zinc finger; Region: zf-dskA_traR; cl00755
929506004273	lipoprotein signal peptidase; Provisional; Region: PRK14791
929506004274	lipoprotein signal peptidase; Provisional; Region: PRK14787
929506004275	Pseudouridylate synthases, 23S RNA-specific [Translation, ribosomal structure and biogenesis]; Region: RluA; COG0564
929506004276	S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site;  Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165
929506004277	RNA binding surface [nucleotide binding]; other site
929506004278	Pseudouridine synthase, RsuA/RluD family; Region: PseudoU_synth_RluCD_like; cd02869
929506004279	active site
929506004280	Pyrimidine operon attenuation protein/uracil phosphoribosyltransferase [Nucleotide transport and metabolism]; Region: PyrR; COG2065
929506004281	Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223
929506004282	active site
929506004283	Fibronectin-binding protein A N-terminus (FbpA); Region: FbpA; pfam05833
929506004284	Glycosyltransferase WbsX; Region: Glyco_tran_WbsX; pfam14307
929506004285	Domain of unknown function (DUF814); Region: DUF814; pfam05670
929506004286	diaminopimelate epimerase; Provisional; Region: dapF; PRK00450
929506004287	Diaminopimelate epimerase; Region: DAP_epimerase; pfam01678
929506004288	Diaminopimelate epimerase; Region: DAP_epimerase; pfam01678
929506004289	Type II secretion system (T2SS), protein E, N-terminal domain; Region: T2SE_Nter; pfam05157
929506004290	RecA-like NTPases. This family includes the NTP binding domain of F1 and V1 H+ATPases, DnaB and related helicases as well as bacterial RecA and related eukaryotic and archaeal recombinases. This group also includes bacterial conjugation proteins and...; Region: RecA-like_NTPases; cl17233
929506004291	Walker A motif; other site
929506004292	ATP binding site [chemical binding]; other site
929506004293	Site-specific recombinase XerD [DNA replication, recombination, and repair]; Region: XerD; COG4974
929506004294	Phage integrase, N-terminal SAM-like domain; Region: Phage_integr_N2; pfam13495
929506004295	phiLC3 phage and phage-related integrases, site-specific recombinases, DNA breaking-rejoining enzymes, C-terminal catalytic domain. This CD includes various bacterial (mainly gram positive) and phage integrases, including those similar to Lactococcus...; Region: INT_phiLC3_C; cd01189
929506004296	Int/Topo IB signature motif; other site
929506004297	Domain of unknown function (DUF955); Region: DUF955; pfam06114
929506004298	Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cl17200
929506004299	non-specific DNA binding site [nucleotide binding]; other site
929506004300	salt bridge; other site
929506004301	sequence-specific DNA binding site [nucleotide binding]; other site
929506004302	ORF6N domain; Region: ORF6N; pfam10543
929506004303	ORF6C domain; Region: ORF6C; pfam10552
929506004304	Bacteriophage Mu Gam like protein; Region: Phage_Mu_Gam; pfam07352
929506004305	ERF superfamily; Region: ERF; pfam04404
929506004306	Domain of unknown function (DUF4373); Region: DUF4373; pfam14297
929506004307	Replication initiation and membrane attachment; Region: DnaB_2; cl12121
929506004308	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
929506004309	Walker A motif; other site
929506004310	ATP binding site [chemical binding]; other site
929506004311	Walker B motif; other site
929506004312	Recombination protein U; Region: RecU; cl01314
929506004313	Terminase small subunit; Region: Terminase_2; pfam03592
929506004314	Phage terminase large subunit; Region: Terminase_3; cl12054
929506004315	Terminase-like family; Region: Terminase_6; pfam03237
929506004316	phage portal protein, SPP1 family; Region: portal_SPP1; TIGR01538
929506004317	Phage Mu protein F like protein; Region: Phage_Mu_F; cl10072
929506004318	P22 coat protein - gene protein 5; Region: P22_CoatProtein; pfam11651
929506004319	Phage head-tail joining protein; Region: Phage_H_T_join; cl11461
929506004320	Bacteriophage protein of unknown function (DUF646); Region: DUF646; pfam04883
929506004321	phage tail tape measure protein, TP901 family, core region; Region: tape_meas_TP901; TIGR01760
929506004322	Phage-related protein [Function unknown]; Region: COG5412
929506004323	membrane protein P6; Region: PHA01399
929506004324	Phage-related protein [Function unknown]; Region: COG4722
929506004325	Phage tail protein; Region: Sipho_tail; cl17486
929506004326	Prophage endopeptidase tail; Region: Prophage_tail; cl12123
929506004327	Protein of unknown function (DUF1664); Region: DUF1664; pfam07889
929506004328	Muramidase (flagellum-specific) [Cell motility and secretion / Intracellular trafficking and secretion]; Region: FlgJ; COG1705
929506004329	Putative peptidoglycan-binding domain-containing protein [Cell envelope biogenesis, outer membrane]; Region: COG3409
929506004330	Putative peptidoglycan binding domain; Region: PG_binding_1; pfam01471
929506004331	Domain of unknown function (DUF4352); Region: DUF4352; pfam11611
929506004332	Predicted hydrolase (metallo-beta-lactamase superfamily) [General function prediction only]; Region: ComEC; COG2333
929506004333	Metallo-beta-lactamase superfamily; Region: Lactamase_B; smart00849
929506004334	RecA-like NTPases. This family includes the NTP binding domain of F1 and V1 H+ATPases, DnaB and related helicases as well as bacterial RecA and related eukaryotic and archaeal recombinases. This group also includes bacterial conjugation proteins and...; Region: RecA-like_NTPases; cl17233
929506004335	Type II secretory pathway, component PulF [Cell motility and secretion / Intracellular trafficking and secretion]; Region: PulF; COG1459
929506004336	Type II secretion system (T2SS), protein F; Region: T2SF; pfam00482
929506004337	Type II secretion system (T2SS), protein F; Region: T2SF; pfam00482
929506004338	InsA N-terminal domain; Region: Zn_Tnp_IS1; pfam03811
929506004339	DDE domain; Region: DDE_Tnp_IS240; pfam13610
929506004340	Integrase core domain; Region: rve; pfam00665
929506004341	Integrase core domain; Region: rve_3; pfam13683
929506004342	Type II secretory pathway, pseudopilin PulG [Cell motility and secretion / Intracellular trafficking and secretion]; Region: PulG; COG2165
929506004343	elongation factor P; Validated; Region: PRK00529
929506004344	Elongation factor P (EF-P) KOW-like domain; Region: EFP_N; pfam08207
929506004345	S1_EF-P_repeat_1: Translation elongation factor P (EF-P), S1-like RNA-binding domain, repeat 1. EF-P stimulates the peptidyltransferase activity in the prokaryotic 70S ribosome. EF-P enhances the synthesis of certain dipeptides with...; Region: S1_EF-P_repeat_1; cd04470
929506004346	RNA binding site [nucleotide binding]; other site
929506004347	S1_EF-P_repeat_2: Translation elongation factor P (EF-P), S1-like RNA-binding domain, repeat 1. EF-P stimulates the peptidyltransferase activity in the prokaryotic 70S ribosome. EF-P enhances the synthesis of certain dipeptides with...; Region: S1_EF-P_repeat_2; cd05794
929506004348	RNA binding site [nucleotide binding]; other site
929506004349	stage III sporulation protein AA; Region: spore_III_AA; TIGR02858
929506004350	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cl17189
929506004351	Walker A motif; other site
929506004352	ATP binding site [chemical binding]; other site
929506004353	Walker B motif; other site
929506004354	stage III sporulation protein SpoAB; Provisional; Region: PRK08307
929506004355	Stage III sporulation protein AC/AD protein family; Region: SpoIIIAC; cl05961
929506004356	stage III sporulation protein AD; Region: spore_III_AD; TIGR02849
929506004357	Stage III sporulation protein AE (spore_III_AE); Region: Spore_III_AE; cl09771
929506004358	Stage III sporulation protein AF (Spore_III_AF); Region: Spore_III_AF; pfam09581
929506004359	stage III sporulation protein AG; Region: spore_III_AG; TIGR02830
929506004360	SpoIIIAH-like protein; Region: SpoIIIAH; pfam12685
929506004361	Asp23 family; Region: Asp23; pfam03780
929506004362	transcription antitermination protein NusB; Reviewed; Region: nusB; PRK00202
929506004363	putative RNA binding site [nucleotide binding]; other site
929506004364	bifunctional 5,10-methylene-tetrahydrofolate dehydrogenase/ 5,10-methylene-tetrahydrofolate cyclohydrolase; Provisional; Region: PRK14172
929506004365	Tetrahydrofolate dehydrogenase/cyclohydrolase, catalytic domain; Region: THF_DHG_CYH; pfam00763
929506004366	NADP binding domain of methylene-tetrahydrofolate dehydrogenase/cyclohydrolase; Region: NAD_bind_m-THF_DH_Cyclohyd; cd01080
929506004367	homodimer interface [polypeptide binding]; other site
929506004368	NADP binding site [chemical binding]; other site
929506004369	substrate binding site [chemical binding]; other site
929506004370	exodeoxyribonuclease VII large subunit; Reviewed; Region: xseA; PRK00286
929506004371	ExoVII_LU_OBF: A subfamily of OB folds corresponding to the N-terminal OB-fold domain of Escherichia coli exodeoxyribonuclease VII (ExoVII) large subunit. E. coli ExoVII is composed of two non-identical subunits. E. coli ExoVII is a...; Region: ExoVII_LU_OBF; cd04489
929506004372	generic binding surface I; other site
929506004373	generic binding surface II; other site
929506004374	exodeoxyribonuclease VII small subunit; Provisional; Region: PRK00977
929506004375	Geranylgeranyl pyrophosphate synthase [Coenzyme metabolism]; Region: IspA; COG0142
929506004376	Trans-Isoprenyl Diphosphate Synthases, head-to-tail; Region: Trans_IPPS_HT; cd00685
929506004377	substrate binding pocket [chemical binding]; other site
929506004378	chain length determination region; other site
929506004379	substrate-Mg2+ binding site; other site
929506004380	catalytic residues [active]
929506004381	aspartate-rich region 1; other site
929506004382	active site lid residues [active]
929506004383	aspartate-rich region 2; other site
929506004384	1-deoxy-D-xylulose-5-phosphate synthase; Provisional; Region: PRK05444
929506004385	Thiamine pyrophosphate (TPP) family, DXS subfamily, TPP-binding module; 1-Deoxy-D-xylulose-5-phosphate synthase (DXS) is a regulatory enzyme of the mevalonate-independent pathway involved in terpenoid biosynthesis. Terpeniods are plant natural products...; Region: TPP_DXS; cd02007
929506004386	TPP-binding site; other site
929506004387	Pyrimidine (PYR) binding domain of 1-deoxy-D-xylulose-5-phosphate synthase (DXS), transketolase (TK), and related proteins; Region: TPP_PYR_DXS_TK_like; cd07033
929506004388	PYR/PP interface [polypeptide binding]; other site
929506004389	dimer interface [polypeptide binding]; other site
929506004390	TPP binding site [chemical binding]; other site
929506004391	Transketolase, C-terminal domain; Region: Transketolase_C; pfam02780
929506004392	Predicted rRNA methylase [Translation, ribosomal structure and biogenesis]; Region: COG1189
929506004393	S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site;  Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165
929506004394	RNA binding surface [nucleotide binding]; other site
929506004395	FtsJ-like methyltransferase; Region: FtsJ; pfam01728
929506004396	NAD kinase [Coenzyme metabolism]; Region: nadF; COG0061
929506004397	ATP-NAD kinase; Region: NAD_kinase; pfam01513
929506004398	arginine repressor; Provisional; Region: argR; PRK00441
929506004399	Arginine repressor, DNA binding domain; Region: Arg_repressor; pfam01316
929506004400	Arginine repressor, C-terminal domain; Region: Arg_repressor_C; pfam02863
929506004401	ATPase involved in DNA repair [DNA replication, recombination, and repair]; Region: RecN; COG0497
929506004402	ATP-binding cassette domain of RecN; Region: ABC_RecN; cd03241
929506004403	Walker A/P-loop; other site
929506004404	ATP binding site [chemical binding]; other site
929506004405	Q-loop/lid; other site
929506004406	ATP-binding cassette domain of RecN; Region: ABC_RecN; cd03241
929506004407	ABC transporter signature motif; other site
929506004408	Walker B; other site
929506004409	D-loop; other site
929506004410	H-loop/switch region; other site
929506004411	stage IV sporulation protein B; Region: spore_IV_B; TIGR02860
929506004412	PDZ domain of bacterial and plant zinc metalloprotases, presumably membrane-associated or integral membrane proteases, which may be involved in signalling and regulatory mechanisms. May be responsible for substrate recognition and/or binding, as most PDZ...; Region: PDZ_metalloprotease; cd00989
929506004413	SpoIVB peptidase S55; Region: Peptidase_S55; pfam05580
929506004414	sporulation transcription factor Spo0A; Region: spore_0_A; TIGR02875
929506004415	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
929506004416	active site
929506004417	phosphorylation site [posttranslational modification]
929506004418	intermolecular recognition site; other site
929506004419	dimerization interface [polypeptide binding]; other site
929506004420	Sporulation initiation factor Spo0A C terminal; Region: Spo0A_C; pfam08769
929506004421	Uncharacterized protein with SCP/PR1 domains [Function unknown]; Region: COG2340
929506004422	SCP_bacterial: SCP-like extracellular protein domain, as found in bacteria and archaea. The wider family of SCP containing proteins includes plant pathogenesis-related protein 1 (PR-1), CRISPs, mammalian cysteine-rich secretory proteins, and allergen 5...; Region: SCP_bacterial; cd05379
929506004423	EDD domain protein, DegV family; Region: DegV; TIGR00762
929506004424	Uncharacterized protein, DegV family COG1307; Region: DegV; pfam02645
929506004425	Transposase domain (DUF772); Region: DUF772; pfam05598
929506004426	Transposase DDE domain; Region: DDE_Tnp_1_6; pfam13751
929506004427	ADP-ribose pyrophosphatase (ADPRase) catalyzes the hydrolysis of ADP-ribose and a variety of additional ADP-sugar conjugates to AMP and ribose-5-phosphate. Like other members of the Nudix hydrolase superfamily, it requires a divalent cation, such as Mg2+; Region: ADPRase_NUDT5; cd03424
929506004428	dimer interface [polypeptide binding]; other site
929506004429	ADP-ribose binding site [chemical binding]; other site
929506004430	active site
929506004431	nudix motif; other site
929506004432	metal binding site [ion binding]; metal-binding site
929506004433	Integral membrane protein DUF95; Region: DUF95; cl00572
929506004434	XerD and XerC integrases, DNA breaking-rejoining enzymes, N- and C-terminal domains. XerD-like integrases are involved in the site-specific integration and excision of lysogenic bacteriophage genomes, transposition of conjugative transposons, termination...; Region: INT_XerDC; cd00798
929506004435	tyrosine recombinase XerD; Region: recomb_XerD; TIGR02225
929506004436	active site
929506004437	Int/Topo IB signature motif; other site
929506004438	D-alanyl-D-alanine carboxypeptidase [Cell envelope biogenesis, outer membrane]; Region: DacC; COG1686
929506004439	Beta-lactamase enzyme family; Region: Beta-lactamase2; cl17872
929506004440	Penicillin-binding protein 5, C-terminal domain; Region: PBP5_C; pfam07943
929506004441	transposase/IS protein; Provisional; Region: PRK09183
929506004442	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
929506004443	Walker A motif; other site
929506004444	ATP binding site [chemical binding]; other site
929506004445	Walker B motif; other site
929506004446	arginine finger; other site
929506004447	Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392
929506004448	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG4584
929506004449	DNA binding site [nucleotide binding]
929506004450	Integrase core domain; Region: rve; pfam00665
929506004451	segregation and condensation protein A; Reviewed; Region: scpA; PRK00104
929506004452	segregation and condensation protein B; Reviewed; Region: scpB; PRK00135
929506004453	Sporulation protein YtfJ (Spore_YtfJ); Region: Spore_YtfJ; cl01596
929506004454	Protein of unknown function (DUF2953); Region: DUF2953; pfam11167
929506004455	Beta-lactamase enzyme family; Region: Beta-lactamase2; cl17872
929506004456	D-alanyl-D-alanine carboxypeptidase [Cell envelope biogenesis, outer membrane]; Region: DacC; COG1686
929506004457	Penicillin-binding protein 5, C-terminal domain; Region: PBP5_C; pfam07943
929506004458	Transcriptional regulator/sugar kinase [Transcription / Carbohydrate transport and metabolism]; Region: NagC; COG1940
929506004459	Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cd00012
929506004460	nucleotide binding site [chemical binding]; other site
929506004461	Site-specific recombinases, DNA invertase Pin homologs [DNA replication, recombination, and repair]; Region: PinR; COG1961
929506004462	Serine Recombinase family, catalytic domain; a DNA binding domain may be present either N- or C-terminal to the catalytic domain. These enzymes perform site-specific recombination of DNA molecules by a concerted, four-strand cleavage and rejoining...; Region: Ser_Recombinase; cd00338
929506004463	catalytic residues [active]
929506004464	catalytic nucleophile [active]
929506004465	Recombinase; Region: Recombinase; pfam07508
929506004466	Recombinase zinc beta ribbon domain; Region: Zn_ribbon_recom; pfam13408
929506004467	Protein of unknown function (DUF998); Region: DUF998; pfam06197
929506004468	Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427
929506004469	haloacid dehalogenase-like hydrolase; Region: Hydrolase_3; pfam08282
929506004470	active site
929506004471	motif I; other site
929506004472	motif II; other site
929506004473	haloacid dehalogenase-like hydrolase; Region: HAD; cl17202
929506004474	Nucleic-acid-binding protein containing Zn-ribbon domain (DUF2082); Region: DUF2082; cl01381
929506004475	FAD/NAD binding domain (electron transfer subunit) of dihydroorotate dehydrogenase-like proteins. Dihydroorotate dehydrogenases (DHODs) catalyze the only redox reaction in pyrimidine de novo biosynthesis. They catalyze the oxidation of (S)-dihydroorotate...; Region: DHOD_e_trans_like; cd06192
929506004476	FAD binding pocket [chemical binding]; other site
929506004477	phosphate binding motif [ion binding]; other site
929506004478	beta-alpha-beta structure motif; other site
929506004479	NAD binding pocket [chemical binding]; other site
929506004480	Iron coordination center [ion binding]; other site
929506004481	tRNA (uracil-5-)-methyltransferase Gid; Reviewed; Region: PRK05335
929506004482	Site-specific recombinases, DNA invertase Pin homologs [DNA replication, recombination, and repair]; Region: PinR; COG1961
929506004483	Serine Recombinase (SR) family, Resolvase and Invertase subfamily, catalytic domain; members contain a C-terminal DNA binding domain. Serine recombinases catalyze site-specific recombination of DNA molecules by a concerted, four-strand cleavage and...; Region: SR_ResInv; cd03768
929506004484	catalytic residues [active]
929506004485	catalytic nucleophile [active]
929506004486	Presynaptic Site I dimer interface [polypeptide binding]; other site
929506004487	Synaptic Antiparallel dimer interface [polypeptide binding]; other site
929506004488	Synaptic Flat tetramer interface [polypeptide binding]; other site
929506004489	Synaptic Site I dimer interface [polypeptide binding]; other site
929506004490	DNA binding site [nucleotide binding]
929506004491	Recombinase; Region: Recombinase; pfam07508
929506004492	Recombinase zinc beta ribbon domain; Region: Zn_ribbon_recom; pfam13408
929506004493	Thiol-activated cytolysin; Region: Thiol_cytolysin; pfam01289
929506004494	Cupin superfamily (DUF985); Region: Cupin_5; pfam06172
929506004495	Site-specific recombinases, DNA invertase Pin homologs [DNA replication, recombination, and repair]; Region: PinR; COG1961
929506004496	Serine Recombinase (SR) family, Resolvase and Invertase subfamily, catalytic domain; members contain a C-terminal DNA binding domain. Serine recombinases catalyze site-specific recombination of DNA molecules by a concerted, four-strand cleavage and...; Region: SR_ResInv; cd03768
929506004497	catalytic residues [active]
929506004498	catalytic nucleophile [active]
929506004499	Presynaptic Site I dimer interface [polypeptide binding]; other site
929506004500	Synaptic Antiparallel dimer interface [polypeptide binding]; other site
929506004501	Synaptic Flat tetramer interface [polypeptide binding]; other site
929506004502	Synaptic Site I dimer interface [polypeptide binding]; other site
929506004503	DNA binding site [nucleotide binding]
929506004504	Recombinase; Region: Recombinase; pfam07508
929506004505	Recombinase zinc beta ribbon domain; Region: Zn_ribbon_recom; pfam13408
929506004506	tRNA (uracil-5-)-methyltransferase Gid; Reviewed; Region: PRK05335
929506004507	Early set domain associated with the catalytic domain of sugar utilizing enzymes at either the N or C terminus; Region: E_set; cl09101
929506004508	Transposase, Mutator family; Region: Transposase_mut; pfam00872
929506004509	MULE transposase domain; Region: MULE; pfam10551
929506004510	Arylsulfatase A and related enzymes [Inorganic ion transport and metabolism]; Region: AslA; COG3119
929506004511	Sulfatase; Region: Sulfatase; pfam00884
929506004512	tyrosine recombinase XerD; Region: recomb_XerD; TIGR02225
929506004513	DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213
929506004514	active site
929506004515	DNA binding site [nucleotide binding]
929506004516	Int/Topo IB signature motif; other site
929506004517	LexA repressor; Validated; Region: PRK00215
929506004518	LexA DNA binding domain; Region: LexA_DNA_bind; pfam01726
929506004519	Peptidase S24 LexA-like proteins are involved in the SOS response leading to the repair of single-stranded DNA within the bacterial cell. This family includes: the lambda repressor CI/C2 family and related bacterial prophage repressor proteins; LexA (EC...; Region: S24_LexA-like; cd06529
929506004520	Catalytic site [active]
929506004521	Nucleoside permease [Nucleotide transport and metabolism]; Region: NupC; COG1972
929506004522	Na+ dependent nucleoside transporter N-terminus; Region: Nucleos_tra2_N; pfam01773
929506004523	Nucleoside recognition; Region: Gate; pfam07670
929506004524	Na+ dependent nucleoside transporter C-terminus; Region: Nucleos_tra2_C; pfam07662
929506004525	Cystathionine beta-lyase family protein involved in aluminum resistance [Inorganic ion transport and metabolism]; Region: COG4100
929506004526	Aluminium resistance protein; Region: Alum_res; pfam06838
929506004527	tRNA delta(2)-isopentenylpyrophosphate transferase; Reviewed; Region: miaA; PRK00091
929506004528	tRNA delta(2)-isopentenylpyrophosphate transferase [Translation, ribosomal structure and biogenesis]; Region: MiaA; COG0324
929506004529	DNA mismatch repair protein; Reviewed; Region: mutL; PRK00095
929506004530	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
929506004531	ATP binding site [chemical binding]; other site
929506004532	Mg2+ binding site [ion binding]; other site
929506004533	G-X-G motif; other site
929506004534	MutL_Trans: transducer domain, having a ribosomal S5 domain 2-like fold, conserved in the C-terminal domain of DNA mismatch repair (MutL/MLH1/PMS2) family. This transducer domain is homologous to the second domain of the DNA gyrase B subunit, which is...; Region: MutL_Trans; cd00782
929506004535	ATP binding site [chemical binding]; other site
929506004536	MutL C terminal dimerisation domain; Region: MutL_C; pfam08676
929506004537	DNA mismatch repair protein MutS; Provisional; Region: PRK05399
929506004538	MutS domain I; Region: MutS_I; pfam01624
929506004539	MutS domain II; Region: MutS_II; pfam05188
929506004540	MutS domain III; Region: MutS_III; pfam05192
929506004541	ATP-binding cassette domain of MutS1 homolog; Region: ABC_MutS1; cd03284
929506004542	Walker A/P-loop; other site
929506004543	ATP binding site [chemical binding]; other site
929506004544	Q-loop/lid; other site
929506004545	ABC transporter signature motif; other site
929506004546	Walker B; other site
929506004547	D-loop; other site
929506004548	H-loop/switch region; other site
929506004549	(dimethylallyl)adenosine tRNA methylthiotransferase; Provisional; Region: PRK14328
929506004550	Uncharacterized protein family UPF0004; Region: UPF0004; pfam00919
929506004551	Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335
929506004552	FeS/SAM binding site; other site
929506004553	TRAM domain; Region: TRAM; pfam01938
929506004554	The MutT pyrophosphohydrolase is a prototypical Nudix hydrolase that catalyzes the hydrolysis of nucleoside and deoxynucleoside triphosphates (NTPs and dNTPs) by substitution at a beta-phosphorus to yield a nucleotide monophosphate (NMP) and inorganic...; Region: MutT_pyrophosphohydrolase; cd03425
929506004555	active site
929506004556	8-oxo-dGMP binding site [chemical binding]; other site
929506004557	nudix motif; other site
929506004558	metal binding site [ion binding]; metal-binding site
929506004559	N-terminal putative catalytic domain of uncharacterized prokaryotic and archeal HKD family nucleases fused to a DEAD/DEAH box helicase domain; Region: PLDc_N_DEXD_b2; cd09204
929506004560	PLD-like domain; Region: PLDc_2; pfam13091
929506004561	putative homodimer interface [polypeptide binding]; other site
929506004562	putative active site [active]
929506004563	catalytic site [active]
929506004564	DEAD-like helicases superfamily; Region: DEXDc; smart00487
929506004565	DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046
929506004566	ATP binding site [chemical binding]; other site
929506004567	putative Mg++ binding site [ion binding]; other site
929506004568	Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079
929506004569	nucleotide binding region [chemical binding]; other site
929506004570	ATP-binding site [chemical binding]; other site
929506004571	Domain of unknown function (DUF3427); Region: DUF3427; pfam11907
929506004572	Acetyltransferases [General function prediction only]; Region: RimI; COG0456
929506004573	Acetyltransferase (GNAT) family; Region: Acetyltransf_1; pfam00583
929506004574	ASC-1 homology domain, subfamily similar to Enterococcus faecalis Ef3133. The ASCH domain, a small beta-barrel domain found in all three kingdoms of life, resembles the RNA-binding PUA domain and may also interact with RNA. ASCH has been proposed to...; Region: ASCH_Ef3133_like; cd06553
929506004575	PemK-like protein; Region: PemK; pfam02452
929506004576	Integrase, catalytic region
929506004577	H+ Antiporter protein; Region: 2A0121; TIGR00900
929506004578	H+ Antiporter protein; Region: 2A0121; TIGR00900
929506004579	Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642
929506004580	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
929506004581	dimer interface [polypeptide binding]; other site
929506004582	phosphorylation site [posttranslational modification]
929506004583	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
929506004584	ATP binding site [chemical binding]; other site
929506004585	Mg2+ binding site [ion binding]; other site
929506004586	G-X-G motif; other site
929506004587	Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745
929506004588	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
929506004589	active site
929506004590	phosphorylation site [posttranslational modification]
929506004591	intermolecular recognition site; other site
929506004592	dimerization interface [polypeptide binding]; other site
929506004593	Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383
929506004594	DNA binding site [nucleotide binding]
929506004595	ABC-type antimicrobial peptide transport system, permease component [Defense mechanisms]; Region: SalY; COG0577
929506004596	FtsX-like permease family; Region: FtsX; pfam02687
929506004597	ABC-type antimicrobial peptide transport system, permease component [Defense mechanisms]; Region: SalY; COG0577
929506004598	FtsX-like permease family; Region: FtsX; pfam02687
929506004599	ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136
929506004600	ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255
929506004601	Walker A/P-loop; other site
929506004602	ATP binding site [chemical binding]; other site
929506004603	Q-loop/lid; other site
929506004604	ABC transporter signature motif; other site
929506004605	Walker B; other site
929506004606	D-loop; other site
929506004607	H-loop/switch region; other site
929506004608	Methyltransferase domain; Region: Methyltransf_31; pfam13847
929506004609	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
929506004610	S-adenosylmethionine binding site [chemical binding]; other site
929506004611	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4185
929506004612	AAA domain; Region: AAA_33; pfam13671
929506004613	BlaR1 peptidase M56; Region: Peptidase_M56; pfam05569
929506004614	Penicillinase repressor; Region: Pencillinase_R; cl17580
929506004615	Transcriptional regulator PadR-like family; Region: PadR; cl17335
929506004616	Predicted transcriptional regulators [Transcription]; Region: COG1695
929506004617	FtsX-like permease family; Region: FtsX; pfam02687
929506004618	ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136
929506004619	ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255
929506004620	Walker A/P-loop; other site
929506004621	ATP binding site [chemical binding]; other site
929506004622	Q-loop/lid; other site
929506004623	ABC transporter signature motif; other site
929506004624	Walker B; other site
929506004625	D-loop; other site
929506004626	H-loop/switch region; other site
929506004627	ATP-binding cassette domain of the drug resistance transporter and related proteins, subfamily A; Region: ABC_DR_subfamily_A; cd03230
929506004628	gallidermin-class lantibiotic protection ABC transporter, ATP-binding subunit; Region: galliderm_ABC; TIGR03740
929506004629	Walker A/P-loop; other site
929506004630	ATP binding site [chemical binding]; other site
929506004631	Q-loop/lid; other site
929506004632	ABC transporter signature motif; other site
929506004633	Walker B; other site
929506004634	D-loop; other site
929506004635	H-loop/switch region; other site
929506004636	Acyl-CoA synthetases (AMP-forming)/AMP-acid ligases II [Lipid metabolism / Secondary metabolites biosynthesis, transport, and catabolism]; Region: CaiC; COG0318
929506004637	Adenylate forming domain, Class I; Region: AFD_class_I; cd04433
929506004638	active site
929506004639	AMP binding site [chemical binding]; other site
929506004640	acyl-activating enzyme (AAE) consensus motif; other site
929506004641	CoA binding site [chemical binding]; other site
929506004642	Thiolase are ubiquitous enzymes that catalyze the reversible thiolytic cleavage of 3-ketoacyl-CoA into acyl-CoA and acetyl-CoA, a 2-step reaction involving a covalent intermediate formed with a catalytic cysteine. They are found in prokaryotes and...; Region: thiolase; cd00751
929506004643	acetyl-CoA acetyltransferases; Region: AcCoA-C-Actrans; TIGR01930
929506004644	dimer interface [polypeptide binding]; other site
929506004645	active site
929506004646	BioY family; Region: BioY; pfam02632
929506004647	The hotdog fold was initially identified in the E. coli FabA (beta-hydroxydecanoyl-acyl carrier protein (ACP)-dehydratase) structure and subsequently in 4HBT (4-hydroxybenzoyl-CoA thioesterase) from Pseudomonas. A number of other seemingly unrelated...; Region: hot_dog; cl00509
929506004648	Amino acid permease; Region: AA_permease_2; pfam13520
929506004649	Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697
929506004650	cAMP-binding proteins - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases [Signal transduction mechanisms]; Region: Crp; COG0664
929506004651	effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cl00047
929506004652	ligand binding site [chemical binding]; other site
929506004653	flexible hinge region; other site
929506004654	putative switch regulator; other site
929506004655	helix_turn_helix, cAMP Regulatory protein; Region: HTH_CRP; smart00419
929506004656	non-specific DNA interactions [nucleotide binding]; other site
929506004657	DNA binding site [nucleotide binding]
929506004658	sequence specific DNA binding site [nucleotide binding]; other site
929506004659	putative cAMP binding site [chemical binding]; other site
929506004660	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3677
929506004661	InsA N-terminal domain; Region: Zn_Tnp_IS1; pfam03811
929506004662	DDE domain; Region: DDE_Tnp_IS240; pfam13610
929506004663	Integrase core domain; Region: rve; pfam00665
929506004664	Integrase core domain; Region: rve_3; pfam13683
929506004665	Transposase, Mutator family; Region: Transposase_mut; pfam00872
929506004666	MULE transposase domain; Region: MULE; pfam10551
929506004667	PAP2_like_1 proteins, a sub-family of PAP2, containing bacterial acid phosphatase, vanadium chloroperoxidases and vanadium bromoperoxidases; Region: PAP2_like_1; cd03380
929506004668	active site
929506004669	Membrane-associated phospholipid phosphatase [Lipid metabolism]; Region: PgpB; COG0671
929506004670	ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132
929506004671	ABC transporter transmembrane region; Region: ABC_membrane; pfam00664
929506004672	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
929506004673	Walker A/P-loop; other site
929506004674	ATP binding site [chemical binding]; other site
929506004675	Q-loop/lid; other site
929506004676	ABC transporter signature motif; other site
929506004677	Walker B; other site
929506004678	D-loop; other site
929506004679	H-loop/switch region; other site
929506004680	ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132
929506004681	ABC transporter transmembrane region; Region: ABC_membrane; pfam00664
929506004682	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
929506004683	Walker A/P-loop; other site
929506004684	ATP binding site [chemical binding]; other site
929506004685	Q-loop/lid; other site
929506004686	ABC transporter signature motif; other site
929506004687	Walker B; other site
929506004688	D-loop; other site
929506004689	H-loop/switch region; other site
929506004690	AraC-type DNA-binding domain-containing proteins [Transcription]; Region: AraC; COG2207
929506004691	Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165
929506004692	Na+/glutamate symporter [Amino acid transport and metabolism]; Region: GltS; COG0786
929506004693	Flavodoxin-like fold; Region: Flavodoxin_2; cl00438
929506004694	Predicted acetyltransferases and hydrolases with the alpha/beta hydrolase fold [General function prediction only]; Region: LipA; COG1075
929506004695	Lyc muramidase is an autolytic lysozyme (autolysin) from Clostridium acetobutylicum encoded by the lyc gene. Lyc has a glycosyl hydrolase family 25 (GH25) catalytic domain.  Endo-N-acetylmuramidases are lysozymes (also referred to as peptidoglycan...; Region: GH25_Lyc-like; cd06525
929506004696	Glycosyl hydrolases family 25; Region: Glyco_hydro_25; pfam01183
929506004697	active site
929506004698	Putative peptidoglycan-binding domain-containing protein [Cell envelope biogenesis, outer membrane]; Region: COG3409
929506004699	Putative peptidoglycan binding domain; Region: PG_binding_1; pfam01471
929506004700	Acetyltransferase (GNAT) family; Region: Acetyltransf_1; pfam00583
929506004701	LytB protein; Region: LYTB; cl00507
929506004702	4-hydroxy-3-methylbut-2-enyl diphosphate reductase/S1 RNA-binding domain protein; Reviewed; Region: PRK00087
929506004703	S1_RPS1_repeat_ec1_hs1: Ribosomal protein S1 (RPS1) domain. RPS1 is a component of the small ribosomal subunit thought to be involved in the recognition and binding of mRNA's during translation initiation. The bacterial RPS1 domain architecture...; Region: S1_RPS1_repeat_ec1_hs1; cd05687
929506004704	RNA binding site [nucleotide binding]; other site
929506004705	S1_RPS1_repeat_ec2_hs2: Ribosomal protein S1 (RPS1) domain. RPS1 is a component of the small ribosomal subunit thought to be involved in the recognition and binding of mRNA's during translation initiation. The bacterial RPS1 domain architecture...; Region: S1_RPS1_repeat_ec2_hs2; cd04465
929506004706	RNA binding site [nucleotide binding]; other site
929506004707	S1_RPS1_repeat_ec3: Ribosomal protein S1 (RPS1) domain. RPS1 is a component of the small ribosomal subunit thought to be involved in the recognition and binding of mRNA's during translation initiation. The bacterial RPS1 domain architecture consists...; Region: S1_RPS1_repeat_ec3; cd05688
929506004708	RNA binding site [nucleotide binding]; other site
929506004709	S1_RPS1_repeat_hs4: Ribosomal protein S1 (RPS1) domain. RPS1 is a component of the small ribosomal subunit thought to be involved in the recognition and binding of mRNA's during translation initiation. The bacterial RPS1 domain architecture consists...; Region: S1_RPS1_repeat_hs4; cd05692
929506004710	RNA binding site [nucleotide binding]; other site
929506004711	cytidylate kinase; Provisional; Region: cmk; PRK00023
929506004712	Cytidine monophosphate kinase (CMPK) catalyzes the reversible phosphorylation of cytidine monophosphate (CMP) to produce cytidine diphosphate (CDP), using ATP as the preferred phosphoryl donor; Region: CMPK; cd02020
929506004713	CMP-binding site; other site
929506004714	The sites determining sugar specificity; other site
929506004715	HI0933-like protein; Region: HI0933_like; pfam03486
929506004716	Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070
929506004717	Transcriptional regulators [Transcription]; Region: RpiR; COG1737
929506004718	Helix-turn-helix domain, rpiR family; Region: HTH_6; pfam01418
929506004719	RpiR-like protein. RpiR contains a SIS (Sugar ISomerase) domain, which is found in many phosphosugar isomerases and phosphosugar binding proteins. In E. coli, rpiR negatively regulates the expression of rpiB gene. Both rpiB and rpiA are ribose phosphate...; Region: SIS_RpiR; cd05013
929506004720	putative active site [active]
929506004721	16S rRNA uridine-516 pseudouridylate synthase and related pseudouridylate synthases [Translation, ribosomal structure and biogenesis]; Region: RsuA; COG1187
929506004722	S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site;  Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165
929506004723	RNA binding surface [nucleotide binding]; other site
929506004724	Pseudouridine synthases, RsuA subfamily; Region: PseudoU_synth_RsuA_like; cd02870
929506004725	active site
929506004726	Predicted N6-adenine-specific DNA methylase [DNA replication, recombination, and repair]; Region: COG0116
929506004727	THUMP domain associated with S-adenosylmethionine-dependent methyltransferases; Region: THUMP_AdoMetMT; cd11715
929506004728	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl17173
929506004729	Ion channel; Region: Ion_trans_2; pfam07885
929506004730	Metal-dependent hydrolases of the beta-lactamase superfamily II [General function prediction only]; Region: COG1237
929506004731	Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386
929506004732	dimer interface [polypeptide binding]; other site
929506004733	putative CheW interface [polypeptide binding]; other site
929506004734	iron-hydroxamate transporter permease subunit; Provisional; Region: PRK10577
929506004735	Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550
929506004736	ABC-ATPase subunit  interface; other site
929506004737	dimer interface [polypeptide binding]; other site
929506004738	putative PBP binding regions; other site
929506004739	ABC-type Fe3+-hydroxamate transport system, periplasmic component [Inorganic ion transport and metabolism]; Region: FepB; COG0614
929506004740	Periplasmic binding protein YvrC.  These proteins are predicted to function as initial receptors in ABC transport of metal ions in eubacteria and archaea.  They belong to the TroA superfamily of periplasmic metal binding proteins that share a distinct...; Region: YvrC; cd01143
929506004741	putative binding site residues; other site
929506004742	threonine-phosphate decarboxylase; Provisional; Region: PRK06358
929506004743	Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609
929506004744	pyridoxal 5'-phosphate binding site [chemical binding]; other site
929506004745	homodimer interface [polypeptide binding]; other site
929506004746	catalytic residue [active]
929506004747	CobD/Cbib protein; Region: CobD_Cbib; pfam03186
929506004748	cobyric acid synthase; Provisional; Region: PRK00784
929506004749	dithiobiotin synthetase; Reviewed; Region: bioD; PRK00090
929506004750	Type 1 glutamine amidotransferase (GATase1) domain found in Cobyric Acid Synthase (CobQ); Region: GATase1_CobQ; cd01750
929506004751	catalytic triad [active]
929506004752	Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067
929506004753	catalytic core [active]
929506004754	cobalamin synthase; Reviewed; Region: cobS; PRK00235
929506004755	Adenosylcobinamide kinase / adenosylcobinamide phosphate guanyltransferase (CobU). CobU is bifunctional cobalbumin biosynthesis enzymes which display adenosylcobinamide kinase and adenosylcobinamide phosphate guanyltransferase activity. This enzyme is a...; Region: CobU; cd00544
929506004756	homotrimer interface [polypeptide binding]; other site
929506004757	Walker A motif; other site
929506004758	GTP binding site [chemical binding]; other site
929506004759	Walker B motif; other site
929506004760	Phosphoribosyltransferase; Region: DBI_PRT; pfam02277
929506004761	Nicotinate-nucleotide-dimethylbenzimidazole phosphoribosyltransferase (DMB-PRT), also called CobT; Region: DMB-PRT_CobT; cd02439
929506004762	putative dimer interface [polypeptide binding]; other site
929506004763	active site pocket [active]
929506004764	putative cataytic base [active]
929506004765	Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067
929506004766	catalytic core [active]
929506004767	transposase/IS protein; Provisional; Region: PRK09183
929506004768	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
929506004769	Walker A motif; other site
929506004770	ATP binding site [chemical binding]; other site
929506004771	Walker B motif; other site
929506004772	arginine finger; other site
929506004773	Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392
929506004774	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG4584
929506004775	DNA binding site [nucleotide binding]
929506004776	Integrase core domain; Region: rve; pfam00665
929506004777	GyrI-like small molecule binding domain; Region: GyrI-like; cl01368
929506004778	ATPase components of ABC transporters with duplicated ATPase domains [General function prediction only]; Region: Uup; COG0488
929506004779	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
929506004780	Walker A/P-loop; other site
929506004781	ATP binding site [chemical binding]; other site
929506004782	Q-loop/lid; other site
929506004783	ABC transporter signature motif; other site
929506004784	Walker B; other site
929506004785	D-loop; other site
929506004786	H-loop/switch region; other site
929506004787	ABC transporter; Region: ABC_tran_2; pfam12848
929506004788	ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221
929506004789	Group II intron, maturase-specific domain; Region: GIIM; pfam08388
929506004790	RT_G2_intron: Reverse transcriptases (RTs) with group II intron origin. RT transcribes DNA using RNA as template. Proteins in this subfamily are found in bacterial and mitochondrial group II introns. Their most probable ancestor was a retrotransposable...; Region: RT_G2_intron; cd01651
929506004791	Reverse transcriptase (RNA-dependent DNA polymerase); Region: RVT_1; pfam00078
929506004792	putative active site [active]
929506004793	putative NTP binding site [chemical binding]; other site
929506004794	putative nucleic acid binding site [nucleotide binding]; other site
929506004795	Predicted permease, member of the PurR regulon [General function prediction only]; Region: yhhT; COG0628
929506004796	Domain of unknown function DUF20; Region: UPF0118; pfam01594
929506004797	TIGR03987 family protein; Region: TIGR03987
929506004798	helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347
929506004799	MarR family; Region: MarR_2; pfam12802
929506004800	FAD dependent oxidoreductase; Region: DAO; pfam01266
929506004801	Glycine/D-amino acid oxidases (deaminating) [Amino acid transport and metabolism]; Region: DadA; COG0665
929506004802	putative aminophosphonate oxidoreductase; Region: Phn_aa_oxid; TIGR03329
929506004803	Xanthine/uracil/vitamin C permease [Nucleotide transport and    metabolism]; Region: COG2252
929506004804	Response regulator of the LytR/AlgR family [Transcription / Signal transduction mechanisms]; Region: LytT; COG3279
929506004805	LytTr DNA-binding domain; Region: LytTR; pfam04397
929506004806	Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase; Region: HATPase_c; pfam02518
929506004807	Accessory gene regulator B; Region: AgrB; pfam04647
929506004808	Bacterial Ig-like domain; Region: Big_5; pfam13205
929506004809	Mannosyl-glycoprotein endo-beta-N-acetylglucosaminidase; Region: Glucosaminidase; pfam01832
929506004810	InsA N-terminal domain; Region: Zn_Tnp_IS1; pfam03811
929506004811	DDE domain; Region: DDE_Tnp_IS240; pfam13610
929506004812	Integrase core domain; Region: rve; pfam00665
929506004813	Integrase core domain; Region: rve_3; pfam13683
929506004814	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
929506004815	Trypsin-like serine protease; Many of these are synthesized as inactive precursor zymogens that are cleaved during limited proteolysis to generate their active forms. Alignment contains also inactive enzymes that have substitutions of the catalytic triad...; Region: Tryp_SPc; cl00149
929506004816	PAP2_like_1 proteins, a sub-family of PAP2, containing bacterial acid phosphatase, vanadium chloroperoxidases and vanadium bromoperoxidases; Region: PAP2_like_1; cd03380
929506004817	active site
929506004818	Membrane-associated phospholipid phosphatase [Lipid metabolism]; Region: PgpB; COG0671
929506004819	Adenylosuccinate lyase [Nucleotide transport and metabolism]; Region: PurB; COG0015
929506004820	Adenylsuccinate lyase (ASL)_subgroup 2; Region: Adenylsuccinate_lyase_2; cd03302
929506004821	tetramer interface [polypeptide binding]; other site
929506004822	active site
929506004823	Histidine-containing phosphocarrier protein (HPr)-like proteins. HPr is a central component of the bacterial phosphoenolpyruvate sugar phosphotransferase system (PTS). The PTS catalyses the phosphorylation of sugar substrates during their translocation...; Region: PTS-HPr_like; cd00367
929506004824	dimerization domain swap beta strand [polypeptide binding]; other site
929506004825	regulatory protein interface [polypeptide binding]; other site
929506004826	active site
929506004827	regulatory phosphorylation site [posttranslational modification]; other site
929506004828	aspartate aminotransferase; Provisional; Region: PRK05764
929506004829	Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609
929506004830	pyridoxal 5'-phosphate binding site [chemical binding]; other site
929506004831	homodimer interface [polypeptide binding]; other site
929506004832	catalytic residue [active]
929506004833	phosphodiesterase; Provisional; Region: PRK12704
929506004834	Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077
929506004835	Zn2+ binding site [ion binding]; other site
929506004836	Mg2+ binding site [ion binding]; other site
929506004837	recombinase A; Provisional; Region: recA; PRK09354
929506004838	RecA is a  bacterial enzyme which has roles in homologous recombination, DNA repair, and the induction of the SOS response.  RecA couples ATP hydrolysis to DNA strand exchange; Region: recA; cd00983
929506004839	hexamer interface [polypeptide binding]; other site
929506004840	Walker A motif; other site
929506004841	ATP binding site [chemical binding]; other site
929506004842	Walker B motif; other site
929506004843	CDP-alcohol phosphatidyltransferase; Region: CDP-OH_P_transf; cl00453
929506004844	2-methylthioadenine synthetase [Translation, ribosomal structure and biogenesis]; Region: MiaB; COG0621
929506004845	Uncharacterized protein family UPF0004; Region: UPF0004; pfam00919
929506004846	Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335
929506004847	FeS/SAM binding site; other site
929506004848	TRAM domain; Region: TRAM; cl01282
929506004849	Domain of unknown function (DUF4117); Region: DUF4117; pfam13491
929506004850	DNA segregation ATPase FtsK/SpoIIIE and related proteins [Cell division and chromosome partitioning]; Region: FtsK; COG1674
929506004851	FtsK/SpoIIIE family; Region: FtsK_SpoIIIE; pfam01580
929506004852	Ftsk gamma domain; Region: Ftsk_gamma; pfam09397
929506004853	Caseinolytic protease (ClpP) is an ATP-dependent protease; Region: Clp_protease_like; cl15763
929506004854	signal peptide peptidase SppA, 36K type; Region: SppA_dom; TIGR00706
929506004855	active site
929506004856	aspartate kinase I; Reviewed; Region: PRK08210
929506004857	Amino Acid Kinases (AAK) superfamily, catalytic domain; present in such enzymes like N-acetylglutamate kinase (NAGK), carbamate kinase (CK), aspartokinase (AK), glutamate-5-kinase (G5K) and UMP kinase (UMPK). The AAK superfamily includes kinases that...; Region: AAK; cl00452
929506004858	nucleotide binding site [chemical binding]; other site
929506004859	substrate binding site [chemical binding]; other site
929506004860	ACT domains of the diaminopimelate-sensitive aspartokinase (AK) isoenzyme AKI; Region: ACT_AKi-DapG-BS_1; cd04914
929506004861	ACT domains of the diaminopimelate-sensitive aspartokinase (AK) isoenzyme AKI; Region: ACT_AKi-DapG-BS_2; cd04937
929506004862	Protein implicated in RNA metabolism, contains PRC-barrel domain [General    function prediction only]; Region: COG1873; cl17889
929506004863	polynucleotide phosphorylase/polyadenylase; Provisional; Region: PRK11824
929506004864	Polyribonucleotide nucleotidyltransferase, repeat 1; Region: RNase_PH_PNPase_1; cd11363
929506004865	RNase E interface [polypeptide binding]; other site
929506004866	trimer interface [polypeptide binding]; other site
929506004867	Polyribonucleotide nucleotidyltransferase, RNA binding domain; Region: PNPase; pfam03726
929506004868	Polyribonucleotide nucleotidyltransferase, repeat 2; Region: RNase_PH_PNPase_2; cd11364
929506004869	RNase E interface [polypeptide binding]; other site
929506004870	trimer interface [polypeptide binding]; other site
929506004871	active site
929506004872	Polynucleotide phosphorylase (PNPase) K homology RNA-binding domain (KH). PNPase is a polyribonucleotide nucleotidyl transferase that degrades mRNA in prokaryotes and plant chloroplasts. The C-terminal region of PNPase contains domains homologous to...; Region: PNPase_KH; cd02393
929506004873	putative nucleic acid binding region [nucleotide binding]; other site
929506004874	G-X-X-G motif; other site
929506004875	S1_PNPase: Polynucleotide phosphorylase (PNPase), ), S1-like RNA-binding domain. PNPase  is a polyribonucleotide nucleotidyl transferase that degrades mRNA. It is a trimeric multidomain protein. The C-terminus contains the S1 domain which binds ssRNA; Region: S1_PNPase; cd04472
929506004876	RNA binding site [nucleotide binding]; other site
929506004877	domain interface; other site
929506004878	Ribosomal protein S15 (prokaryotic)_S13 (eukaryotic) binds the central domain of 16S rRNA and is required for assembly of the small ribosomal subunit and for intersubunit association, thus representing a key element in the assembly of the whole ribosome; Region: Ribosomal_S15p_S13e; cd00353
929506004879	16S/18S rRNA binding site [nucleotide binding]; other site
929506004880	S13e-L30e interaction site [polypeptide binding]; other site
929506004881	25S rRNA binding site [nucleotide binding]; other site
929506004882	bifunctional riboflavin kinase/FMN adenylyltransferase; Reviewed; Region: PRK05627
929506004883	FAD synthetase, N-terminal domain of the bifunctional enzyme; Region: FAD_synthetase_N; cd02064
929506004884	active site
929506004885	Riboflavin kinase; Region: Flavokinase; pfam01687
929506004886	tRNA pseudouridine synthase B; Provisional; Region: truB; PRK00130
929506004887	Pseudouridine synthase, Escherichia coli TruB like; Region: PseudoU_synth_EcTruB; cd02573
929506004888	RNA binding site [nucleotide binding]; other site
929506004889	active site
929506004890	Exopolyphosphatase-related proteins [General function prediction only]; Region: COG0618
929506004891	DHH family; Region: DHH; pfam01368
929506004892	DHHA1 domain; Region: DHHA1; pfam02272
929506004893	ribosome-binding factor A; Validated; Region: rbfA; PRK00521
929506004894	Translation initiation factor IF-2, N-terminal region; Region: IF2_N; pfam04760
929506004895	translation initiation factor IF-2; Region: IF-2; TIGR00487
929506004896	Translation initiation factor IF-2, N-terminal region; Region: IF2_N; pfam04760
929506004897	Initiation Factor 2 (IF2)/ eukaryotic Initiation Factor 5B (eIF5B) family; Region: IF2_eIF5B; cd01887
929506004898	G1 box; other site
929506004899	putative GEF interaction site [polypeptide binding]; other site
929506004900	GTP/Mg2+ binding site [chemical binding]; other site
929506004901	Switch I region; other site
929506004902	G2 box; other site
929506004903	G3 box; other site
929506004904	Switch II region; other site
929506004905	G4 box; other site
929506004906	G5 box; other site
929506004907	This family represents the domain II of bacterial Initiation Factor 2 (IF2) and its eukaryotic mitochondrial homologue mtIF2. IF2, the largest initiation factor is an essential GTP binding protein. In E. coli three natural forms of IF2 exist in the cell; Region: IF2_mtIF2_II; cd03702
929506004908	Translation-initiation factor 2; Region: IF-2; pfam11987
929506004909	mtIF2_IVc: this family represents the C2 subdomain of domain IV of mitochondrial translation initiation factor 2 (mtIF2) which adopts a beta-barrel fold displaying a high degree of structural similarity with domain II of the translation elongation factor...; Region: mtIF2_IVc; cd03692
929506004910	Ylxr homologs; group of conserved hypothetical bacterial proteins of unknown function; structure revealed putative RNA binding cleft; proteins are encoded by an operon that includes other proteins involved in transcription and/or translation; Region: YlxR; cd00279
929506004911	putative RNA binding cleft [nucleotide binding]; other site
929506004912	transcription elongation factor NusA; Provisional; Region: nusA; PRK12327
929506004913	NusA N-terminal domain; Region: NusA_N; pfam08529
929506004914	S1_NusA: N-utilizing substance A protein (NusA), S1-like RNA-binding domain. S1-like RNA-binding domains are found in a wide variety of RNA-associated proteins. NusA is a transcription elongation factor containing an N-terminal catalytic domain and three...; Region: S1_NusA; cd04455
929506004915	RNA binding site [nucleotide binding]; other site
929506004916	homodimer interface [polypeptide binding]; other site
929506004917	NusA-like KH domain; Region: KH_5; pfam13184
929506004918	NusA_K homology RNA-binding domain (KH). NusA is an essential multifunctional transcription elongation factor that is universally conserved among prokaryotes and archaea. NusA anti-termination function plays an important role in the expression of...; Region: NusA_KH; cd02134
929506004919	G-X-X-G motif; other site
929506004920	ribosome maturation protein RimP; Reviewed; Region: PRK00092
929506004921	Sm and related proteins; Region: Sm_like; cl00259
929506004922	Bacillus subtilis YxlS-like, C-terminal domain; Region: YlxS_C; cd01734
929506004923	putative oligomer interface [polypeptide binding]; other site
929506004924	putative RNA binding site [nucleotide binding]; other site
929506004925	DNA polymerase III PolC; Validated; Region: polC; PRK00448
929506004926	DNA polymerase III polC-type N-terminus; Region: DNA_pol3_alph_N; pfam11490
929506004927	polC_OBF: A subfamily of OB folds corresponding to the N-terminal OB-fold nucleic acid binding domain of Bacillus subtilis type C replicative DNA polymerase III alpha subunit (polC). Replication in B. subtilis and Staphylococcus aureus requires two...; Region: polC_OBF; cd04484
929506004928	generic binding surface II; other site
929506004929	generic binding surface I; other site
929506004930	Polymerase and Histidinol Phosphatase domain; Region: PHP; cl17102
929506004931	active site
929506004932	DEDDh 3'-5' exonuclease domain family; Region: DEDDh; cd06127
929506004933	active site
929506004934	catalytic site [active]
929506004935	substrate binding site [chemical binding]; other site
929506004936	Polymerase and Histidinol Phosphatase domain of alpha-subunit of bacterial polymerase III at PolC gene; Region: PHP_PolIIIA_POLC; cd07435
929506004937	4-hydroxy-3-methylbut-2-en-1-yl diphosphate synthase; Reviewed; Region: ispG; PRK00366
929506004938	4-hydroxy-3-methylbut-2-en-1-yl diphosphate synthase; Validated; Region: PRK00694
929506004939	4-hydroxy-3-methylbut-2-en-1-yl diphosphate synthase; Validated; Region: PRK00694
929506004940	RseP-like Site-2 proteases (S2P), zinc metalloproteases (MEROPS family M50A), cleave transmembrane domains of substrate proteins, regulating intramembrane proteolysis (RIP) of diverse signal transduction mechanisms. In Escherichia coli, the S2P homolog...; Region: S2P-M50_PDZ_RseP-like; cd06163
929506004941	Predicted membrane-associated Zn-dependent proteases 1 [Cell envelope biogenesis, outer membrane]; Region: COG0750
929506004942	active site
929506004943	PDZ domain of bacterial and plant zinc metalloprotases, presumably membrane-associated or integral membrane proteases, which may be involved in signalling and regulatory mechanisms. May be responsible for substrate recognition and/or binding, as most PDZ...; Region: PDZ_metalloprotease; cd00989
929506004944	protein binding site [polypeptide binding]; other site
929506004945	Site-2 protease (S2P) class of zinc metalloproteases (MEROPS family M50) cleaves transmembrane domains of substrate proteins, regulating intramembrane proteolysis (RIP) of diverse signal transduction mechanisms. Members of this family use proteolytic...; Region: S2P-M50; cl10020
929506004946	putative substrate binding region [chemical binding]; other site
929506004947	1-deoxy-D-xylulose 5-phosphate reductoisomerase; Provisional; Region: PRK05447
929506004948	1-deoxy-D-xylulose 5-phosphate reductoisomerase; Region: DXP_reductoisom; pfam02670
929506004949	1-deoxy-D-xylulose 5-phosphate reductoisomerase C-terminal; Region: DXP_redisom_C; pfam08436
929506004950	DXP reductoisomerase C-terminal domain; Region: DXPR_C; pfam13288
929506004951	CDP-diglyceride synthetase [Lipid metabolism]; Region: CdsA; COG0575
929506004952	Cytidylyltransferase family; Region: CTP_transf_1; pfam01148
929506004953	Cis (Z)-Isoprenyl Diphosphate Synthases (cis-IPPS); homodimers which catalyze the successive 1'-4 condensation of the isopentenyl diphosphate (IPP) molecule to trans,trans-farnesyl diphosphate (FPP) or to cis,trans-FPP to form long-chain polyprenyl...; Region: CIS_IPPS; cl00230
929506004954	Undecaprenyl pyrophosphate synthase [Lipid metabolism]; Region: UppS; COG0020
929506004955	catalytic residue [active]
929506004956	putative FPP diphosphate  binding site; other site
929506004957	putative FPP binding hydrophobic cleft; other site
929506004958	dimer interface [polypeptide binding]; other site
929506004959	putative IPP diphosphate binding site; other site
929506004960	ribosome recycling factor; Reviewed; Region: frr; PRK00083
929506004961	Ribosome recycling factor (RRF). Ribosome recycling factor dissociates the posttermination complex, composed of the ribosome, deacylated tRNA, and mRNA, after termination of translation.  Thus ribosomes are "recycled" and ready for another...; Region: RRF; cd00520
929506004962	hinge region; other site
929506004963	UMP kinase (UMPK)-Ec, the microbial/chloroplast uridine monophosphate kinase (uridylate kinase) enzyme that catalyzes UMP phosphorylation and plays a key role in pyrimidine nucleotide biosynthesis; regulation of this process is via feed-back control and...; Region: AAK_UMPK-PyrH-Ec; cd04254
929506004964	putative nucleotide binding site [chemical binding]; other site
929506004965	uridine monophosphate binding site [chemical binding]; other site
929506004966	homohexameric interface [polypeptide binding]; other site
929506004967	elongation factor Ts; Provisional; Region: tsf; PRK09377
929506004968	UBA/TS-N domain; Region: UBA; pfam00627
929506004969	Elongation factor TS; Region: EF_TS; pfam00889
929506004970	Elongation factor TS; Region: EF_TS; pfam00889
929506004971	Ribosomal protein S2 (RPS2), involved in formation of the translation initiation complex, where it might contact the messenger RNA and several components of the ribosome. It has been shown that in Escherichia coli RPS2 is essential for the binding of...; Region: RPS2; cd01425
929506004972	rRNA interaction site [nucleotide binding]; other site
929506004973	S8 interaction site; other site
929506004974	putative laminin-1 binding site; other site
929506004975	transcriptional repressor CodY; Validated; Region: PRK04158
929506004976	CodY GAF-like domain; Region: CodY; pfam06018
929506004977	CodY helix-turn-helix domain; Region: HTH_CodY; pfam08222
929506004978	DNA topoisomerase I; Validated; Region: PRK05582
929506004979	TOPRIM_TopoIA_TopoI: The topoisomerase-primase (TORPIM) domain found in members of the type IA family of DNA topoisomerases (Topo IA) similar to Escherichia coli DNA topoisomerase I.   Type IA DNA topoisomerases remove (relax) negative supercoils in the...; Region: TOPRIM_TopoIA_TopoI; cd03363
929506004980	active site
929506004981	interdomain interaction site; other site
929506004982	putative metal-binding site [ion binding]; other site
929506004983	nucleotide binding site [chemical binding]; other site
929506004984	DNA Topoisomerase, subtype IA; DNA-binding, ATP-binding and catalytic domain of bacterial DNA topoisomerases I and III, and eukaryotic DNA topoisomerase III and eubacterial and archael reverse gyrases. Topoisomerases clevage single or double stranded DNA...; Region: TOP1Ac; cd00186
929506004985	domain I; other site
929506004986	DNA binding groove [nucleotide binding]
929506004987	phosphate binding site [ion binding]; other site
929506004988	domain II; other site
929506004989	domain III; other site
929506004990	nucleotide binding site [chemical binding]; other site
929506004991	catalytic site [active]
929506004992	domain IV; other site
929506004993	Topoisomerase DNA binding C4 zinc finger; Region: zf-C4_Topoisom; pfam01396
929506004994	Topoisomerase DNA binding C4 zinc finger; Region: zf-C4_Topoisom; pfam01396
929506004995	Topoisomerase DNA binding C4 zinc finger; Region: zf-C4_Topoisom; pfam01396
929506004996	Predicted Rossmann fold nucleotide-binding protein involved in DNA uptake [DNA replication, recombination, and repair / Intracellular trafficking and secretion]; Region: Smf; COG0758
929506004997	DNA protecting protein DprA; Region: dprA; TIGR00732
929506004998	Predicted ATPase with chaperone activity [Posttranslational modification, protein turnover, chaperones]; Region: COG0606
929506004999	Subunit ChlI of Mg-chelatase; Region: ChlI; pfam13541
929506005000	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
929506005001	Walker A motif; other site
929506005002	ATP binding site [chemical binding]; other site
929506005003	Walker B motif; other site
929506005004	Magnesium chelatase, subunit ChlI; Region: Mg_chelatase_2; pfam13335
929506005005	hypothetical protein; Reviewed; Region: PRK12497
929506005006	bacterial Ribonuclease HII-like; Region: RNase_HII_bacteria_HII_like; cd07182
929506005007	RNA/DNA hybrid binding site [nucleotide binding]; other site
929506005008	active site
929506005009	GTPase YlqF; Reviewed; Region: rbgA; PRK09563
929506005010	Circularly permuted YlqF GTPase; Region: YlqF; cd01856
929506005011	GTP/Mg2+ binding site [chemical binding]; other site
929506005012	G4 box; other site
929506005013	G5 box; other site
929506005014	G1 box; other site
929506005015	Switch I region; other site
929506005016	G2 box; other site
929506005017	G3 box; other site
929506005018	Switch II region; other site
929506005019	50S ribosomal protein L19; Provisional; Region: rplS; PRK05338
929506005020	tRNA (guanine-N(1)-)-methyltransferase; Reviewed; Region: trmD; PRK00026
929506005021	16S rRNA-processing protein RimM; Provisional; Region: rimM; PRK00122
929506005022	RimM N-terminal domain; Region: RimM; pfam01782
929506005023	PRC-barrel domain; Region: PRC; pfam05239
929506005024	Predicted RNA-binding protein (contains KH domain) [General function prediction only]; Region: COG1837
929506005025	hypothetical protein; Provisional; Region: PRK00468
929506005026	30S ribosomal protein S16; Reviewed; Region: rpsP; PRK00040
929506005027	signal recognition particle protein; Provisional; Region: PRK10867
929506005028	SRP54-type protein, helical bundle domain; Region: SRP54_N; smart00963
929506005029	The signal recognition particle (SRP) mediates the transport to or across the plasma membrane in bacteria and the endoplasmic reticulum in eukaryotes. SRP recognizes N-terminal sighnal sequences of newly synthesized polypeptides at the ribosome. The...; Region: SRP; cd03115
929506005030	P loop; other site
929506005031	GTP binding site [chemical binding]; other site
929506005032	Signal peptide binding domain; Region: SRP_SPB; pfam02978
929506005033	putative DNA-binding protein; Validated; Region: PRK00118
929506005034	signal recognition particle-docking protein FtsY; Provisional; Region: PRK10416
929506005035	SRP54-type protein, helical bundle domain; Region: SRP54_N; pfam02881
929506005036	The signal recognition particle (SRP) mediates the transport to or across the plasma membrane in bacteria and the endoplasmic reticulum in eukaryotes. SRP recognizes N-terminal sighnal sequences of newly synthesized polypeptides at the ribosome. The...; Region: SRP; cd03115
929506005037	P loop; other site
929506005038	GTP binding site [chemical binding]; other site
929506005039	chromosome segregation protein SMC, common bacterial type; Region: SMC_prok_B; TIGR02168
929506005040	ATP-binding cassette domain of barmotin, a member of the SMC protein family; Region: ABC_SMC_barmotin; cd03278
929506005041	Walker A/P-loop; other site
929506005042	ATP binding site [chemical binding]; other site
929506005043	Q-loop/lid; other site
929506005044	SMC proteins Flexible Hinge Domain; Region: SMC_hinge; smart00968
929506005045	ATP-binding cassette domain of barmotin, a member of the SMC protein family; Region: ABC_SMC_barmotin; cd03278
929506005046	ABC transporter signature motif; other site
929506005047	Walker B; other site
929506005048	D-loop; other site
929506005049	H-loop/switch region; other site
929506005050	Early set domain associated with the catalytic domain of sugar utilizing enzymes at either the N or C terminus; Region: E_set; cl09101
929506005051	X25 domain of Bacillus acidopullulyticus pullulanase and similar proteins; Region: X25_BaPul_like; cd12962
929506005052	N-terminal Early set domain associated with the catalytic domain of cyclomaltodextrinase and pullulan-degrading enzymes; Region: E_set_CDase_PDE_N; cd02857
929506005053	homodimer interface [polypeptide binding]; other site
929506005054	Alpha amylase catalytic domain found in cyclomaltodextrinases and related proteins; Region: AmyAc_CMD; cd11338
929506005055	active site
929506005056	homodimer interface [polypeptide binding]; other site
929506005057	catalytic site [active]
929506005058	Stage V sporulation protein S (SpoVS); Region: SpoVS; pfam04232
929506005059	Elongator protein 3, MiaB family, Radical SAM; Region: Elp3; smart00729
929506005060	Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335
929506005061	FeS/SAM binding site; other site
929506005062	ribonuclease III; Reviewed; Region: rnc; PRK00102
929506005063	RIBOc. Ribonuclease III C terminal domain. This group consists of eukaryotic, bacterial and archeal ribonuclease III (RNAse III) proteins. RNAse III is a double stranded RNA-specific endonuclease. Prokaryotic RNAse III is important in...; Region: RIBOc; cd00593
929506005064	dimerization interface [polypeptide binding]; other site
929506005065	active site
929506005066	metal binding site [ion binding]; metal-binding site
929506005067	Double-stranded RNA binding motif. Binding is not sequence specific but is highly specific for double stranded RNA. Found in a variety of proteins including dsRNA dependent protein kinase PKR, RNA helicases, Drosophila staufen protein, E. coli RNase III; Region: DSRM; cd00048
929506005068	dsRNA binding site [nucleotide binding]; other site
929506005069	acyl carrier protein; Provisional; Region: acpP; PRK00982
929506005070	putative phosphate acyltransferase; Provisional; Region: PRK05331
929506005071	50S ribosomal protein L32; Reviewed; Region: rpmF; PRK12286
929506005072	Uncharacterized ACR, COG1399; Region: DUF177; pfam02620
929506005073	acetate kinase A/propionate kinase 2; Reviewed; Region: PRK00180
929506005074	propionate/acetate kinase; Provisional; Region: PRK12379
929506005075	phosphotransacetylase; Reviewed; Region: eutD; PRK09653
929506005076	hypothetical protein; Provisional; Region: PRK13670
929506005077	HIGH Nucleotidyl Transferase; Region: HIGH_NTase1; cl17673
929506005078	sporulation integral membrane protein YlbJ; Region: spore_ylbJ; TIGR02871
929506005079	Nucleoside recognition; Region: Gate; pfam07670
929506005080	phosphopantetheine adenylyltransferase; Provisional; Region: coaD; PRK00168
929506005081	Phosphopantetheine adenylyltransferase; Region: PPAT; cd02163
929506005082	active site
929506005083	(T/H)XGH motif; other site
929506005084	Conserved hypothetical protein 95; Region: Cons_hypoth95; pfam03602
929506005085	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
929506005086	S-adenosylmethionine binding site [chemical binding]; other site
929506005087	ATP-dependent DNA helicase RecG; Provisional; Region: PRK10917
929506005088	RecG_wedge_OBF: A subfamily of OB folds corresponding to the OB fold found in the N-terminal (wedge) domain of Escherichia coli RecG. RecG is a branched-DNA-specific helicase, which catalyzes the interconversion of a DNA replication fork to a...; Region: RecG_wedge_OBF; cd04488
929506005089	ssDNA binding site; other site
929506005090	generic binding surface II; other site
929506005091	DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046
929506005092	ATP binding site [chemical binding]; other site
929506005093	putative Mg++ binding site [ion binding]; other site
929506005094	Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079
929506005095	nucleotide binding region [chemical binding]; other site
929506005096	ATP-binding site [chemical binding]; other site
929506005097	DAK2 domain fusion protein YloV; Region: YloV; TIGR03599
929506005098	DAK2 domain; Region: Dak2; pfam02734
929506005099	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG1302
929506005100	50S ribosomal protein L28; Reviewed; Region: rpmB; PRK00359
929506005101	Thiamine pyrophosphokinase; Region: TPK; cd07995
929506005102	thiamine pyrophosphokinase; Region: thi_PPkinase; TIGR01378
929506005103	active site
929506005104	dimerization interface [polypeptide binding]; other site
929506005105	thiamine binding site [chemical binding]; other site
929506005106	Pentose-5-phosphate-3-epimerase [Carbohydrate transport and metabolism]; Region: Rpe; COG0036
929506005107	Ribulose-5-phosphate 3-epimerase (RPE). This enzyme catalyses the interconversion of D-ribulose 5-phosphate (Ru5P) into D-xylulose 5-phosphate, as part of the Calvin cycle (reductive pentose phosphate pathway) in chloroplasts and in the oxidative pentose...; Region: RPE; cd00429
929506005108	substrate binding site [chemical binding]; other site
929506005109	hexamer interface [polypeptide binding]; other site
929506005110	metal binding site [ion binding]; metal-binding site
929506005111	GTPase RsgA; Reviewed; Region: PRK00098
929506005112	S1_YloQ_GTPase: YloQ GTase family (also known as YjeQ and CpgA), S1-like RNA-binding domain. Proteins in the YloQ GTase family bind the ribosome and have GTPase activity. The precise role of this family is unknown. The protein structure is composed of...; Region: S1_YloQ_GTPase; cd04466
929506005113	RNA binding site [nucleotide binding]; other site
929506005114	homodimer interface [polypeptide binding]; other site
929506005115	Ribosomal interacting GTPase YjeQ/EngC, a circularly permuted subfamily of the Ras GTPases; Region: YjeQ_EngC; cd01854
929506005116	GTPase/Zn-binding domain interface [polypeptide binding]; other site
929506005117	GTP/Mg2+ binding site [chemical binding]; other site
929506005118	G4 box; other site
929506005119	G5 box; other site
929506005120	G1 box; other site
929506005121	Switch I region; other site
929506005122	G2 box; other site
929506005123	G3 box; other site
929506005124	Switch II region; other site
929506005125	Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220
929506005126	Catalytic domain of Protein Kinases; Region: PKc; cd00180
929506005127	active site
929506005128	ATP binding site [chemical binding]; other site
929506005129	substrate binding site [chemical binding]; other site
929506005130	activation loop (A-loop); other site
929506005131	PASTA domain of bacterial serine/threonine kinase pknB-like proteins. PknB is a member of a group of related transmembrane sensor kinases present in many gram positive bacteria, which has been shown to regulate cell shape in Mycobacterium tubercolosis; Region: PASTA_pknB; cd06577
929506005132	PASTA domain of bacterial serine/threonine kinase pknB-like proteins. PknB is a member of a group of related transmembrane sensor kinases present in many gram positive bacteria, which has been shown to regulate cell shape in Mycobacterium tubercolosis; Region: PASTA_pknB; cd06577
929506005133	PASTA domain of bacterial serine/threonine kinase pknB-like proteins. PknB is a member of a group of related transmembrane sensor kinases present in many gram positive bacteria, which has been shown to regulate cell shape in Mycobacterium tubercolosis; Region: PASTA_pknB; cd06577
929506005134	PASTA domain of bacterial serine/threonine kinase pknB-like proteins. PknB is a member of a group of related transmembrane sensor kinases present in many gram positive bacteria, which has been shown to regulate cell shape in Mycobacterium tubercolosis; Region: PASTA_pknB; cd06577
929506005135	Serine/threonine phosphatases, family 2C, catalytic domain; The protein architecture and deduced catalytic mechanism of PP2C phosphatases are similar to the PP1, PP2A, PP2B family of protein Ser/Thr phosphatases, with which PP2C shares no sequence...; Region: PP2Cc; cd00143
929506005136	active site
929506005137	ribosomal RNA large subunit methyltransferase N; Provisional; Region: PRK14454
929506005138	Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335
929506005139	FeS/SAM binding site; other site
929506005140	16S rRNA methyltransferase B; Provisional; Region: PRK14902
929506005141	NusB family; Region: NusB; pfam01029
929506005142	putative RNA binding site [nucleotide binding]; other site
929506005143	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
929506005144	S-adenosylmethionine binding site [chemical binding]; other site
929506005145	Putative neutral zinc metallopeptidase; Region: Zn_peptidase_2; pfam04298
929506005146	methionyl-tRNA formyltransferase; Reviewed; Region: fmt; PRK00005
929506005147	Methionyl-tRNA formyltransferase, N-terminal hydrolase domain; Region: FMT_core_Met-tRNA-FMT_N; cd08646
929506005148	putative active site [active]
929506005149	substrate binding site [chemical binding]; other site
929506005150	putative cosubstrate binding site; other site
929506005151	catalytic site [active]
929506005152	C-terminal domain of Formyltransferase and other enzymes; Region: Met_tRNA_FMT_C; cd08704
929506005153	substrate binding site [chemical binding]; other site
929506005154	Polypeptide or peptide deformylase; a family of metalloenzymes that catalyzes the removal of the N-terminal formyl group in a growing polypeptide chain following translation initiation during protein synthesis in prokaryotes. These enzymes utilize Fe(II)...; Region: Pep_deformylase; cd00487
929506005155	active site
929506005156	catalytic residues [active]
929506005157	metal binding site [ion binding]; metal-binding site
929506005158	primosome assembly protein PriA; Validated; Region: PRK05580
929506005159	DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046
929506005160	ATP binding site [chemical binding]; other site
929506005161	putative Mg++ binding site [ion binding]; other site
929506005162	Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cl17351
929506005163	bifunctional phosphopantothenoylcysteine decarboxylase/phosphopantothenate synthase; Validated; Region: PRK05579
929506005164	Flavoprotein; Region: Flavoprotein; pfam02441
929506005165	DNA / pantothenate metabolism flavoprotein; Region: DFP; pfam04127
929506005166	DNA-directed RNA polymerase subunit omega; Reviewed; Region: rpoZ; PRK00392
929506005167	Guanylate kinase [Nucleotide transport and metabolism]; Region: Gmk; COG0194
929506005168	Guanosine monophosphate kinase (GMPK, EC 2.7.4.8), also known as guanylate kinase (GKase), catalyzes the reversible phosphoryl transfer from adenosine triphosphate (ATP) to guanosine monophosphate (GMP) to yield adenosine diphosphate (ADP) and guanosine...; Region: GMPK; cd00071
929506005169	catalytic site [active]
929506005170	G-X2-G-X-G-K; other site
929506005171	hypothetical protein; Provisional; Region: PRK04323
929506005172	hypothetical protein; Provisional; Region: PRK11820
929506005173	YicC-like family, N-terminal region; Region: YicC_N; pfam03755
929506005174	Domain of unknown function (DUF1732); Region: DUF1732; pfam08340
929506005175	Xanthine/uracil/vitamin C permease [Nucleotide transport and    metabolism]; Region: COG2252
929506005176	Sulfate transporter family; Region: Sulfate_transp; pfam00916
929506005177	Type II (periplasmic) bacterial L-asparaginase; Region: L-asparaginase_II; cd08964
929506005178	active site
929506005179	homotetramer interface [polypeptide binding]; other site
929506005180	homodimer interface [polypeptide binding]; other site
929506005181	stage IV sporulation protein A; Region: spore_IV_A; TIGR02836
929506005182	Rat sarcoma (Ras)-like superfamily of small guanosine triphosphatases (GTPases); Region: Ras_like_GTPase; cd00882
929506005183	G1 box; other site
929506005184	GTP/Mg2+ binding site [chemical binding]; other site
929506005185	G2 box; other site
929506005186	Switch I region; other site
929506005187	G3 box; other site
929506005188	Switch II region; other site
929506005189	G5 box; other site
929506005190	NAD(P)H-dependent glycerol-3-phosphate dehydrogenase; Validated; Region: gpsA; PRK00094
929506005191	NAD-dependent glycerol-3-phosphate dehydrogenase N-terminus; Region: NAD_Gly3P_dh_N; pfam01210
929506005192	NAD-dependent glycerol-3-phosphate dehydrogenase C-terminus; Region: NAD_Gly3P_dh_C; pfam07479
929506005193	GTP-binding protein Der; Reviewed; Region: PRK00093
929506005194	EngA1 GTPase contains the first domain of EngA; Region: EngA1; cd01894
929506005195	G1 box; other site
929506005196	GTP/Mg2+ binding site [chemical binding]; other site
929506005197	Switch I region; other site
929506005198	G2 box; other site
929506005199	Switch II region; other site
929506005200	G3 box; other site
929506005201	G4 box; other site
929506005202	G5 box; other site
929506005203	EngA2 GTPase contains the second domain of EngA; Region: EngA2; cd01895
929506005204	G1 box; other site
929506005205	GTP/Mg2+ binding site [chemical binding]; other site
929506005206	Switch I region; other site
929506005207	G2 box; other site
929506005208	G3 box; other site
929506005209	Switch II region; other site
929506005210	G4 box; other site
929506005211	G5 box; other site
929506005212	putative FeS-containing Cyanobacterial-specific oxidoreductase; Region: cyano_FeS_chp; TIGR03279
929506005213	PDZ domain, also called DHR (Dlg homologous region) or GLGF (after a conserved sequence motif). Many PDZ domains bind C-terminal polypeptides, though binding to internal (non-C-terminal) polypeptides and even to lipids has been demonstrated; Region: PDZ; cl00117
929506005214	Protein of unknown function (DUF512); Region: DUF512; pfam04459
929506005215	PhoU domain; Region: PhoU; pfam01895
929506005216	phosphate transport system regulatory protein PhoU; Region: phoU_full; TIGR02135
929506005217	PhoU domain; Region: PhoU; pfam01895
929506005218	ABC-type phosphate transport system, ATPase component [Inorganic ion transport and metabolism]; Region: PstB; COG1117
929506005219	ATP-binding cassette domain of the phosphate transport system; Region: ABC_PstB_phosphate_transporter; cd03260
929506005220	Walker A/P-loop; other site
929506005221	ATP binding site [chemical binding]; other site
929506005222	Q-loop/lid; other site
929506005223	ABC transporter signature motif; other site
929506005224	Walker B; other site
929506005225	D-loop; other site
929506005226	H-loop/switch region; other site
929506005227	ABC-type phosphate transport system, permease component [Inorganic ion transport and metabolism]; Region: PstA; COG0581
929506005228	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
929506005229	dimer interface [polypeptide binding]; other site
929506005230	conserved gate region; other site
929506005231	putative PBP binding loops; other site
929506005232	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cl00427
929506005233	ABC-ATPase subunit interface; other site
929506005234	phosphate ABC transporter, permease protein PstC; Region: phosphate_pstC; TIGR02138
929506005235	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
929506005236	dimer interface [polypeptide binding]; other site
929506005237	conserved gate region; other site
929506005238	putative PBP binding loops; other site
929506005239	ABC-ATPase subunit interface; other site
929506005240	PBP superfamily domain; Region: PBP_like_2; cl17296
929506005241	Methyl-accepting chemotaxis protein [Cell motility and secretion / Signal transduction mechanisms]; Region: Tar; COG0840
929506005242	Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225
929506005243	dimerization interface [polypeptide binding]; other site
929506005244	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
929506005245	dimer interface [polypeptide binding]; other site
929506005246	phosphorylation site [posttranslational modification]
929506005247	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
929506005248	ATP binding site [chemical binding]; other site
929506005249	Mg2+ binding site [ion binding]; other site
929506005250	G-X-G motif; other site
929506005251	Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745
929506005252	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
929506005253	active site
929506005254	phosphorylation site [posttranslational modification]
929506005255	intermolecular recognition site; other site
929506005256	dimerization interface [polypeptide binding]; other site
929506005257	Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383
929506005258	DNA binding site [nucleotide binding]
929506005259	Multi-copper polyphenol oxidoreductase laccase; Region: Cu-oxidase_4; pfam02578
929506005260	Multicopper polyphenol oxidase (laccase) [Secondary metabolites biosynthesis, transport and catabolism]; Region: yfiH; COG1496
929506005261	transcriptional regulator NrdR; Validated; Region: nrdR; PRK00464
929506005262	ATP cone domain; Region: ATP-cone; pfam03477
929506005263	Protein implicated in RNA metabolism, contains PRC-barrel domain [General    function prediction only]; Region: COG1873; cl17889
929506005264	bidirectional hydrogenase complex protein HoxU; Validated; Region: PRK07569
929506005265	2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207
929506005266	catalytic loop [active]
929506005267	iron binding site [ion binding]; other site
929506005268	[FeFe] hydrogenase, group A; Region: FeFe_hydrog_A; TIGR02512
929506005269	4Fe-4S binding domain; Region: Fer4; pfam00037
929506005270	Iron only hydrogenase large subunit, C-terminal domain; Region: Fe_hyd_lg_C; pfam02906
929506005271	Iron hydrogenase small subunit; Region: Fe_hyd_SSU; smart00902
929506005272	Na+/H+-dicarboxylate symporters [Energy production and conversion]; Region: GltP; COG1301
929506005273	Sodium:dicarboxylate symporter family; Region: SDF; pfam00375
929506005274	sporulation sigma factor SigG; Reviewed; Region: PRK08215
929506005275	Sigma-70 region 2; Region: Sigma70_r2; pfam04542
929506005276	Sigma-70 region 3; Region: Sigma70_r3; pfam04539
929506005277	Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171
929506005278	DNA binding residues [nucleotide binding]
929506005279	sporulation sigma factor SigE; Reviewed; Region: PRK08301
929506005280	Sigma-70 region 2; Region: Sigma70_r2; pfam04542
929506005281	Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171
929506005282	DNA binding residues [nucleotide binding]
929506005283	Sporulation factor SpoIIGA; Region: Peptidase_U4; pfam03419
929506005284	sigma-E processing peptidase SpoIIGA; Region: spore_II_GA; TIGR02854
929506005285	cell division protein FtsZ; Validated; Region: PRK09330
929506005286	FtsZ is a GTPase that is similar to the eukaryotic tubulins and is essential for cell division in prokaryotes.  FtsZ is capable of polymerizing in a GTP-driven process into structures similar to those formed by tubulin. FtsZ forms a ring-shaped septum at...; Region: FtsZ_type1; cd02201
929506005287	nucleotide binding site [chemical binding]; other site
929506005288	SulA interaction site; other site
929506005289	Cell division ATPase FtsA [Cell division and chromosome partitioning]; Region: ftsA; COG0849
929506005290	Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cd00012
929506005291	nucleotide binding site [chemical binding]; other site
929506005292	SHS2 domain inserted in FTSA; Region: SHS2_FTSA; pfam02491
929506005293	Cell division protein FtsA; Region: FtsA; pfam14450
929506005294	Tfp pilus assembly protein, pilus retraction ATPase PilT [Cell motility and secretion / Intracellular trafficking and secretion]; Region: PilT; COG2805
929506005295	RecA-like NTPases. This family includes the NTP binding domain of F1 and V1 H+ATPases, DnaB and related helicases as well as bacterial RecA and related eukaryotic and archaeal recombinases. This group also includes bacterial conjugation proteins and...; Region: RecA-like_NTPases; cl17233
929506005296	Walker A motif; other site
929506005297	ATP binding site [chemical binding]; other site
929506005298	Walker B motif; other site
929506005299	sporulation sigma factor SigK; Reviewed; Region: PRK05803
929506005300	Sigma-70 region 2; Region: Sigma70_r2; pfam04542
929506005301	Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171
929506005302	DNA binding residues [nucleotide binding]
929506005303	Cell division protein FtsI/penicillin-binding protein 2 [Cell envelope biogenesis, outer membrane]; Region: FtsI; COG0768
929506005304	Penicillin binding protein transpeptidase domain; Region: Transpeptidase; cl17760
929506005305	Uridine kinase [Nucleotide transport and metabolism]; Region: Udk; COG0572
929506005306	Uridine monophosphate kinase (UMPK, EC 2.7.1.48), also known as uridine kinase or uridine-cytidine kinase (UCK), catalyzes the reversible phosphoryl transfer from ATP to uridine or cytidine to yield UMP or CMP. In the primidine nucleotide-salvage pathway; Region: UMPK; cd02023
929506005307	Sugar specificity; other site
929506005308	Pyrimidine base specificity; other site
929506005309	ATP-binding site [chemical binding]; other site
929506005310	Collagenase and related proteases [Posttranslational modification, protein turnover, chaperones]; Region: COG0826
929506005311	Quinolinate phosphoribosyl transferase, C-terminal domain; Region: QRPTase_C; pfam01729
929506005312	Peptidase family U32; Region: Peptidase_U32; pfam01136
929506005313	Predicted O-methyltransferase [General function prediction only]; Region: COG4122
929506005314	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
929506005315	S-adenosylmethionine binding site [chemical binding]; other site
929506005316	YceG-like family; Region: YceG; pfam02618
929506005317	proteins similar to Escherichia coli yceG; Region: yceG_like; cd08010
929506005318	dimerization interface [polypeptide binding]; other site
929506005319	Predicted membrane GTPase involved in stress response [Signal transduction mechanisms]; Region: TypA; COG1217
929506005320	Tyrosine phosphorylated protein A (TypA)/BipA family belongs to ribosome-binding GTPases; Region: TypA_BipA; cd01891
929506005321	G1 box; other site
929506005322	putative GEF interaction site [polypeptide binding]; other site
929506005323	GTP/Mg2+ binding site [chemical binding]; other site
929506005324	Switch I region; other site
929506005325	G2 box; other site
929506005326	G3 box; other site
929506005327	Switch II region; other site
929506005328	G4 box; other site
929506005329	G5 box; other site
929506005330	BipA_TypA_II: domain II of BipA (also called TypA) having homology to domain II of the elongation factors (EFs) EF-G and EF-Tu.  BipA is a highly conserved protein with global regulatory properties in Escherichia coli. BipA is phosphorylated on a...; Region: BipA_TypA_II; cd03691
929506005331	BipA_TypA_C: a C-terminal portion of BipA or TypA having homology to the C terminal domains of the elongation factors EF-G and EF-2. A member of the ribosome binding GTPase superfamily, BipA is widely distributed in bacteria and plants.  BipA is a highly...; Region: BipA_TypA_C; cd03710
929506005332	hypothetical protein; Provisional; Region: PRK13676
929506005333	mRNA degradation ribonucleases J1/J2 (metallo-beta-lactamase superfamily) [Translation, ribosomal structure and biogenesis; Replication, recombination and repair]; Region: COG0595
929506005334	Metallo-beta-lactamase superfamily; Region: Lactamase_B; smart00849
929506005335	RNA-metabolising metallo-beta-lactamase; Region: RMMBL; pfam07521
929506005336	Ferric uptake regulator(Fur) and related metalloregulatory proteins; typically iron-dependent, DNA-binding repressors and activators; Region: Fur_like; cd07153
929506005337	metal binding site 2 [ion binding]; metal-binding site
929506005338	putative DNA binding helix; other site
929506005339	metal binding site 1 [ion binding]; metal-binding site
929506005340	dimer interface [polypeptide binding]; other site
929506005341	structural Zn2+ binding site [ion binding]; other site
929506005342	Protein of unknown function (DUF1292); Region: DUF1292; pfam06949
929506005343	Holliday junction resolvase-like protein; Reviewed; Region: PRK00109
929506005344	hypothetical protein; Provisional; Region: PRK05473
929506005345	alanyl-tRNA synthetase; Reviewed; Region: alaS; PRK00252
929506005346	Alanyl-tRNA synthetase (AlaRS) class II core catalytic domain. AlaRS is a homodimer. It is responsible for the attachment of alanine to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for ATP-dependent...; Region: AlaRS_core; cd00673
929506005347	motif 1; other site
929506005348	active site
929506005349	motif 2; other site
929506005350	motif 3; other site
929506005351	Threonyl and Alanyl tRNA synthetase second additional domain; Region: tRNA_SAD; smart00863
929506005352	Predicted tRNA(5-methylaminomethyl-2-thiouridylate) methyltransferase, contains the PP-loop ATPase domain [Translation, ribosomal structure and biogenesis]; Region: TrmU; COG0482
929506005353	tRNA methyl transferase. This family represents tRNA(5-methylaminomethyl-2-thiouridine)-methyltransferase which is involved in the biosynthesis of the modified nucleoside 5-methylaminomethyl-2-thiouridine present in the wobble position of some tRNAs; Region: tRNA_Me_trans; cd01998
929506005354	Ligand Binding Site [chemical binding]; other site
929506005355	NifU homolog involved in Fe-S cluster formation [Energy production and conversion]; Region: IscU; COG0822
929506005356	Iron-sulfur cluster scaffold-like proteins; Region: IscU_like; cd06664
929506005357	trimerization site [polypeptide binding]; other site
929506005358	active site
929506005359	Cysteine sulfinate desulfinase/cysteine desulfurase and related enzymes [Amino acid transport and metabolism]; Region: NifS; COG1104
929506005360	cysteine desulfurase NifS; Region: FeS_nifS; TIGR03402
929506005361	pyridoxal 5'-phosphate binding pocket [chemical binding]; other site
929506005362	catalytic residue [active]
929506005363	Predicted transcriptional regulator [Transcription]; Region: COG1959
929506005364	Transcriptional regulator; Region: Rrf2; cl17282
929506005365	recombination factor protein RarA; Reviewed; Region: PRK13342
929506005366	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
929506005367	Walker A motif; other site
929506005368	ATP binding site [chemical binding]; other site
929506005369	Walker B motif; other site
929506005370	arginine finger; other site
929506005371	MgsA AAA+ ATPase C terminal; Region: MgsA_C; pfam12002
929506005372	EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2).  The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948
929506005373	Metallo-beta-lactamase superfamily; Region: Lactamase_B; smart00849
929506005374	ATPase components of ABC transporters with duplicated ATPase domains [General function prediction only]; Region: Uup; COG0488
929506005375	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
929506005376	Walker A/P-loop; other site
929506005377	ATP binding site [chemical binding]; other site
929506005378	Q-loop/lid; other site
929506005379	ABC transporter signature motif; other site
929506005380	Walker B; other site
929506005381	D-loop; other site
929506005382	H-loop/switch region; other site
929506005383	ABC transporter; Region: ABC_tran_2; pfam12848
929506005384	ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221
929506005385	DNA topoisomerase III; Provisional; Region: PRK07726
929506005386	TOPRIM_TopoIA_TopoIII: The topoisomerase-primase (TORPIM) domain found in members of the type IA family of DNA topoisomerases (Topo IA) similar to topoisomerase III. Type IA DNA topoisomerases remove (relax) negative supercoils in the DNA by: cleaving...; Region: TOPRIM_TopoIA_TopoIII; cd03362
929506005387	active site
929506005388	putative interdomain interaction site [polypeptide binding]; other site
929506005389	putative metal-binding site [ion binding]; other site
929506005390	putative nucleotide binding site [chemical binding]; other site
929506005391	DNA Topoisomerase, subtype IA; DNA-binding, ATP-binding and catalytic domain of bacterial DNA topoisomerases I and III, and eukaryotic DNA topoisomerase III and eubacterial and archael reverse gyrases. Topoisomerases clevage single or double stranded DNA...; Region: TOP1Ac; cl11986
929506005392	domain I; other site
929506005393	DNA binding groove [nucleotide binding]
929506005394	phosphate binding site [ion binding]; other site
929506005395	domain II; other site
929506005396	domain III; other site
929506005397	nucleotide binding site [chemical binding]; other site
929506005398	catalytic site [active]
929506005399	domain IV; other site
929506005400	C-terminal repeat of topoisomerase; Region: Toprim_Crpt; pfam13342
929506005401	tRNA pseudouridine synthase A; Reviewed; Region: PRK12434
929506005402	Eukaryotic and bacterial pseudouridine synthases similar to E.  coli TruA; Region: PseudoU_synth_EcTruA; cd02570
929506005403	dimerization interface 3.5A [polypeptide binding]; other site
929506005404	active site
929506005405	The GIY-YIG domain of uncharacterized protein family UPF0213 related to structure-specific endonuclease SLX1; Region: GIY-YIG_UPF0213; cd10456
929506005406	GIY-YIG motif/motif A; other site
929506005407	putative active site [active]
929506005408	putative metal binding site [ion binding]; other site
929506005409	Predicted transcriptional regulator [Transcription]; Region: COG3655
929506005410	sequence-specific DNA binding site [nucleotide binding]; other site
929506005411	salt bridge; other site
929506005412	Domain of unknown function (DUF4173); Region: DUF4173; pfam13777
929506005413	Transposase domain (DUF772); Region: DUF772; pfam05598
929506005414	Transposase DDE domain; Region: DDE_Tnp_1_6; pfam13751
929506005415	Arsenate Reductase (ArsC) family; composed of TRX-fold arsenic reductases and similar proteins including the transcriptional regulator, Spx. ArsC catalyzes the reduction of arsenate [As(V)] to arsenite [As(III)], using reducing equivalents derived from...; Region: ArsC_family; cd02977
929506005416	ArsC family; Region: ArsC; pfam03960
929506005417	catalytic residue [active]
929506005418	Permeases of the drug/metabolite transporter (DMT) superfamily [Carbohydrate transport and metabolism / Amino acid transport and metabolism / General function prediction only]; Region: RhaT; COG0697
929506005419	Sortase D (SrtD) is a membrane transpeptidase found in gram-positive bacteria that anchors surface proteins to peptidoglycans of the bacterial cell wall envelope. This involves a transpeptidation reaction in which the surface protein substrate is cleaved...; Region: Sortase_D_4; cd05828
929506005420	active site
929506005421	catalytic site [active]
929506005422	Spore germination protein; Region: Spore_permease; cl17796
929506005423	Spore germination protein; Region: Spore_permease; cl17796
929506005424	Spore germination protein; Region: Spore_permease; cl17796
929506005425	germination protein, Ger(x)C family; Region: spore_ger_x_C; TIGR02887
929506005426	Spore germination B3/ GerAC like, C-terminal; Region: Spore_GerAC; pfam05504
929506005427	Bacillus/Clostridium GerA spore germination protein; Region: GerA; pfam03323
929506005428	ATP-dependent chaperone ClpB; Region: chaperone_ClpB; TIGR03346
929506005429	Clp amino terminal domain; Region: Clp_N; pfam02861
929506005430	Clp amino terminal domain; Region: Clp_N; pfam02861
929506005431	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
929506005432	Walker A motif; other site
929506005433	ATP binding site [chemical binding]; other site
929506005434	Walker B motif; other site
929506005435	arginine finger; other site
929506005436	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
929506005437	Walker A motif; other site
929506005438	ATP binding site [chemical binding]; other site
929506005439	Walker B motif; other site
929506005440	arginine finger; other site
929506005441	C-terminal, D2-small domain, of ClpB protein; Region: ClpB_D2-small; pfam10431
929506005442	ATP-dependent DNA helicase RecQ; Region: recQ; TIGR01389
929506005443	DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046
929506005444	ATP binding site [chemical binding]; other site
929506005445	putative Mg++ binding site [ion binding]; other site
929506005446	Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079
929506005447	nucleotide binding region [chemical binding]; other site
929506005448	ATP-binding site [chemical binding]; other site
929506005449	This DNA-binding domain is found in the RecQ helicase among others and has a helix-turn-helix structure; Region: RQC; smart00956
929506005450	HRDC domain; Region: HRDC; pfam00570
929506005451	HRDC domain; Region: HRDC; pfam00570
929506005452	TRX family; composed of two groups: Group I, which includes proteins that exclusively encode a TRX domain; and Group II, which are composed of fusion proteins of TRX and additional domains. Group I TRX is a small ancient protein that alter the redox...; Region: TRX_family; cd02947
929506005453	catalytic residues [active]
929506005454	channel protein, hemolysin III family; Region: hlyIII; TIGR01065
929506005455	Predicted membrane protein, hemolysin III homolog [General function prediction only]; Region: COG1272
929506005456	Domain of unknown function (DUF1836); Region: DUF1836; pfam08876
929506005457	Fe2+ transport system protein B [Inorganic ion transport and metabolism]; Region: FeoB; COG0370
929506005458	Ferrous iron transport protein B (FeoB) family; Region: FeoB; cd01879
929506005459	G1 box; other site
929506005460	GTP/Mg2+ binding site [chemical binding]; other site
929506005461	Switch I region; other site
929506005462	G2 box; other site
929506005463	G3 box; other site
929506005464	Switch II region; other site
929506005465	G4 box; other site
929506005466	G5 box; other site
929506005467	Nucleoside recognition; Region: Gate; pfam07670
929506005468	Ferrous iron transport protein B C terminus; Region: FeoB_C; pfam07664
929506005469	Nucleoside recognition; Region: Gate; pfam07670
929506005470	FeoA domain; Region: FeoA; pfam04023
929506005471	manganese transport transcriptional regulator; Provisional; Region: PRK03902
929506005472	Iron dependent repressor, N-terminal DNA binding domain; Region: Fe_dep_repress; pfam01325
929506005473	Iron dependent repressor, metal binding and dimerisation domain; Region: Fe_dep_repr_C; pfam02742
929506005474	RT_G2_intron: Reverse transcriptases (RTs) with group II intron origin. RT transcribes DNA using RNA as template. Proteins in this subfamily are found in bacterial and mitochondrial group II introns. Their most probable ancestor was a retrotransposable...; Region: RT_G2_intron; cd01651
929506005475	Reverse transcriptase (RNA-dependent DNA polymerase); Region: RVT_1; pfam00078
929506005476	putative active site [active]
929506005477	putative NTP binding site [chemical binding]; other site
929506005478	putative nucleic acid binding site [nucleotide binding]; other site
929506005479	Group II intron, maturase-specific domain; Region: GIIM; pfam08388
929506005480	undecaprenyldiphospho-muramoylpentapeptide beta-N-acetylglucosaminyltransferase; Reviewed; Region: PRK12446
929506005481	MurG is an N-acetylglucosaminyltransferase, the last enzyme involved in the intracellular phase of peptidoglycan biosynthesis. It transfers N-acetyl-D-glucosamine (GlcNAc) from UDP-GlcNAc to the C4 hydroxyl of a lipid-linked N-acetylmuramoyl pentapeptide...; Region: GT1_MurG; cd03785
929506005482	active site
929506005483	homodimer interface [polypeptide binding]; other site
929506005484	Small, acid-soluble spore proteins, alpha/beta type; Region: SASP; pfam00269
929506005485	Na+-driven multidrug efflux pump [Defense mechanisms]; Region: NorM; COG0534
929506005486	Subfamily of the multidrug and toxic compound extrusion (MATE)-like proteins similar to Streptococcus aureus MepA; Region: MATE_MepA_like; cd13143
929506005487	Small, acid-soluble spore proteins, alpha/beta type; Region: SASP; pfam00269
929506005488	Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642
929506005489	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
929506005490	dimer interface [polypeptide binding]; other site
929506005491	phosphorylation site [posttranslational modification]
929506005492	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
929506005493	ATP binding site [chemical binding]; other site
929506005494	Mg2+ binding site [ion binding]; other site
929506005495	G-X-G motif; other site
929506005496	single-stranded-DNA-specific exonuclease RecJ; Region: recJ; TIGR00644
929506005497	DHH family; Region: DHH; pfam01368
929506005498	DHHA1 domain; Region: DHHA1; pfam02272
929506005499	Endonuclease IV [DNA replication, recombination, and repair]; Region: Nfo; COG0648
929506005500	AP endonuclease family 2; These endonucleases play a role in DNA repair. Cleave phosphodiester bonds at apurinic or apyrimidinic sites; the alignment also contains hexulose-6-phosphate isomerases, enzymes that catalyze the epimerization of...; Region: AP2Ec; cd00019
929506005501	AP (apurinic/apyrimidinic) site pocket; other site
929506005502	DNA interaction; other site
929506005503	Metal-binding active site; metal-binding site
929506005504	Conserved protein/domain typically associated with flavoprotein oxygenases, DIM6/NTAB family [General function prediction only]; Region: COG1853
929506005505	Heavy-metal-associated domain (HMA) is a conserved domain of approximately 30 amino acid residues found in a number of proteins that transport or detoxify heavy metals, for example, the CPx-type heavy metal ATPases and copper chaperones. HMA domain...; Region: HMA; cd00371
929506005506	metal-binding site [ion binding]
929506005507	Cation transport ATPase [Inorganic ion transport and metabolism]; Region: ZntA; COG2217
929506005508	Heavy-metal-associated domain (HMA) is a conserved domain of approximately 30 amino acid residues found in a number of proteins that transport or detoxify heavy metals, for example, the CPx-type heavy metal ATPases and copper chaperones. HMA domain...; Region: HMA; cd00371
929506005509	metal-binding site [ion binding]
929506005510	Cation transport ATPase [Inorganic ion transport and metabolism]; Region: ZntA; COG2217
929506005511	Heavy-metal-associated domain (HMA) is a conserved domain of approximately 30 amino acid residues found in a number of proteins that transport or detoxify heavy metals, for example, the CPx-type heavy metal ATPases and copper chaperones. HMA domain...; Region: HMA; cd00371
929506005512	metal-binding site [ion binding]
929506005513	E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122
929506005514	Soluble P-type ATPase [General function prediction only]; Region: COG4087
929506005515	Uncharacterized family 2; belongs to a superfamily containing transcriptional regulators CsoR (copper-sensitive operon repressor), RcnR, and FrmR, and related domains; this family was previously known as part of DUF156; Region: CsoR-like_DUF156_2; cd10159
929506005516	putative homodimer interface [polypeptide binding]; other site
929506005517	putative homotetramer interface [polypeptide binding]; other site
929506005518	putative allosteric switch controlling residues; other site
929506005519	putative metal binding site [ion binding]; other site
929506005520	putative homodimer-homodimer interface [polypeptide binding]; other site
929506005521	Predicted Zn-dependent peptidases [General function prediction only]; Region: PqqL; COG0612
929506005522	Insulinase (Peptidase family M16); Region: Peptidase_M16; pfam00675
929506005523	Peptidase M16 inactive domain; Region: Peptidase_M16_C; pfam05193
929506005524	3-hydroxybutyryl-CoA dehydratase; Validated; Region: PRK05809
929506005525	Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558
929506005526	substrate binding site [chemical binding]; other site
929506005527	oxyanion hole (OAH) forming residues; other site
929506005528	trimer interface [polypeptide binding]; other site
929506005529	Electron transfer flavoprotein, alpha subunit [Energy production and conversion]; Region: FixB; COG2025
929506005530	The electron transfer flavoprotein (ETF) serves as a specific electron acceptor for various mitochondrial dehydrogenases. ETF transfers electrons to the main respiratory chain via ETF-ubiquinone oxidoreductase. ETF is an heterodimer that consists of an...; Region: ETF_alpha; cd01715
929506005531	Electron transfer flavoprotein FAD-binding domain; Region: ETF_alpha; pfam00766
929506005532	The electron transfer flavoprotein (ETF) serves as a specific electron acceptor for various mitochondrial dehydrogenases. ETF transfers electrons to the main respiratory chain via ETF-ubiquinone oxidoreductase. ETF is an heterodimer that consists of an...; Region: ETF_beta; cd01714
929506005533	Ligand binding site [chemical binding]; other site
929506005534	Electron transfer flavoprotein domain; Region: ETF; pfam01012
929506005535	Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960
929506005536	Short chain acyl-CoA dehydrogenases and eukaryotic short/branched chain acyl-CoA dehydrogenases; Region: SCAD_SBCAD; cd01158
929506005537	FAD binding site [chemical binding]; other site
929506005538	homotetramer interface [polypeptide binding]; other site
929506005539	substrate binding pocket [chemical binding]; other site
929506005540	catalytic base [active]
929506005541	DNA topoisomerase IV subunit A; Provisional; Region: PRK13979
929506005542	DNA Topoisomerase, subtype IIA; domain A'; bacterial DNA topoisomerase IV (C subunit, ParC), bacterial DNA gyrases (A subunit, GyrA),mammalian DNA toposiomerases II. DNA topoisomerases are essential enzymes that regulate the conformational changes...; Region: TOP4c; cd00187
929506005543	CAP-like domain; other site
929506005544	active site
929506005545	primary dimer interface [polypeptide binding]; other site
929506005546	DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989
929506005547	DNA topoisomerase IV subunit B; Reviewed; Region: PRK05559
929506005548	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
929506005549	ATP binding site [chemical binding]; other site
929506005550	Mg2+ binding site [ion binding]; other site
929506005551	G-X-G motif; other site
929506005552	TopoIIA_Trans_DNA_gyrase: Transducer domain, having a ribosomal S5 domain 2-like fold, of the type found in proteins of the type IIA family of DNA topoisomerases similar to the B subunits of E. coli DNA gyrase and E. coli Topoisomerase IV which are; Region: TopoII_Trans_DNA_gyrase; cd00822
929506005553	anchoring element; other site
929506005554	dimer interface [polypeptide binding]; other site
929506005555	ATP binding site [chemical binding]; other site
929506005556	Topoisomerase-primase domain. This is a nucleotidyl transferase/hydrolase domain found in type IA, type IIA and type IIB topoisomerases, bacterial DnaG-type primases, small primase-like proteins from bacteria and archaea, OLD family nucleases from...; Region: TOPRIM; cl00718
929506005557	active site
929506005558	metal binding site [ion binding]; metal-binding site
929506005559	DNA gyrase B subunit, carboxyl terminus; Region: DNA_gyraseB_C; pfam00986
929506005560	InsA N-terminal domain; Region: Zn_Tnp_IS1; pfam03811
929506005561	DDE domain; Region: DDE_Tnp_IS240; pfam13610
929506005562	Integrase core domain; Region: rve; pfam00665
929506005563	Integrase core domain; Region: rve_3; pfam13683
929506005564	TPR repeat; Region: TPR_11; pfam13414
929506005565	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
929506005566	binding surface
929506005567	TPR motif; other site
929506005568	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
929506005569	binding surface
929506005570	TPR repeat; Region: TPR_11; pfam13414
929506005571	TPR motif; other site
929506005572	TPR repeat; Region: TPR_11; pfam13414
929506005573	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
929506005574	binding surface
929506005575	TPR motif; other site
929506005576	TPR repeat; Region: TPR_11; pfam13414
929506005577	purine nucleoside phosphorylase; Reviewed; Region: deoD; PRK05819
929506005578	Uridine phosphorylase [Nucleotide transport and metabolism]; Region: Udp; COG2820
929506005579	Four helix bundle sensory module for signal transduction; Region: 4HB_MCP_1; pfam12729
929506005580	Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer); Region: MA; smart00283
929506005581	Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386
929506005582	dimer interface [polypeptide binding]; other site
929506005583	putative CheW interface [polypeptide binding]; other site
929506005584	glycyl radical enzyme, PFL2/glycerol dehydratase family; Region: PFL2-3; TIGR01774
929506005585	Ribonucleotide reductase and Pyruvate formate lyase; Region: RNR_PFL; cl09939
929506005586	glycyl-radical enzyme activating protein family; Region: PFLE_PFLC; TIGR02494
929506005587	Four helix bundle sensory module for signal transduction; Region: 4HB_MCP_1; pfam12729
929506005588	Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cl01054
929506005589	dimerization interface [polypeptide binding]; other site
929506005590	Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386
929506005591	Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer); Region: MA; smart00283
929506005592	Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386
929506005593	dimer interface [polypeptide binding]; other site
929506005594	putative CheW interface [polypeptide binding]; other site
929506005595	heavy metal translocating P-type ATPase; Region: ATPase-IB_hvy; TIGR01525
929506005596	E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122
929506005597	Soluble P-type ATPase [General function prediction only]; Region: COG4087
929506005598	Cyclopropane fatty acid synthase and related methyltransferases [Cell envelope biogenesis, outer membrane]; Region: Cfa; COG2230
929506005599	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl17173
929506005600	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
929506005601	S-adenosylmethionine binding site [chemical binding]; other site
929506005602	ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136
929506005603	ATP-binding cassette domain of the nitrate and sulfonate transporters; Region: ABC_NrtD_SsuB_transporters; cd03293
929506005604	Walker A/P-loop; other site
929506005605	ATP binding site [chemical binding]; other site
929506005606	Q-loop/lid; other site
929506005607	ABC transporter signature motif; other site
929506005608	Walker B; other site
929506005609	D-loop; other site
929506005610	H-loop/switch region; other site
929506005611	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
929506005612	dimer interface [polypeptide binding]; other site
929506005613	conserved gate region; other site
929506005614	putative PBP binding loops; other site
929506005615	ABC-ATPase subunit interface; other site
929506005616	ABC-type nitrate/sulfonate/bicarbonate transport systems, periplasmic components [Inorganic ion transport and metabolism]; Region: TauA; COG0715
929506005617	Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of  substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cl17432
929506005618	flavodoxin; Provisional; Region: PRK05568
929506005619	Uncharacterized flavoproteins [Energy production and conversion]; Region: FpaA; COG0426
929506005620	Chemotaxis signal transduction protein [Cell motility and secretion / Signal transduction mechanisms]; Region: CheW; COG0835
929506005621	FOG: CheY-like receiver [Signal transduction mechanisms]; Region: CheY; COG0784
929506005622	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
929506005623	active site
929506005624	phosphorylation site [posttranslational modification]
929506005625	intermolecular recognition site; other site
929506005626	dimerization interface [polypeptide binding]; other site
929506005627	30S ribosomal protein S4; Validated; Region: rpsD; PRK05327
929506005628	Ribosomal protein S4/S9 N-terminal domain; Region: Ribosomal_S4; pfam00163
929506005629	S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site;  Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165
929506005630	RNA binding surface [nucleotide binding]; other site
929506005631	Cache domain; Region: Cache_2; cl07034
929506005632	Methyl-accepting chemotaxis protein [Cell motility and secretion / Signal transduction mechanisms]; Region: Tar; COG0840
929506005633	Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225
929506005634	dimerization interface [polypeptide binding]; other site
929506005635	Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386
929506005636	dimer interface [polypeptide binding]; other site
929506005637	putative CheW interface [polypeptide binding]; other site
929506005638	Isochorismatase family; Region: Isochorismatase; pfam00857
929506005639	Cysteine hydrolases; This family contains amidohydrolases, like CSHase (N-carbamoylsarcosine amidohydrolase), involved in creatine metabolism and nicotinamidase, converting nicotinamide to nicotinic acid and ammonia in the pyridine nucleotide cycle. It...; Region: cysteine_hydrolases; cd00431
929506005640	catalytic triad [active]
929506005641	conserved cis-peptide bond; other site
929506005642	Cache is an extracellular domain that is predicted to have a role in small-molecule recognition in a wide range of proteins; Region: Cache_2; smart01049
929506005643	Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer); Region: MA; smart00283
929506005644	Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386
929506005645	dimer interface [polypeptide binding]; other site
929506005646	putative CheW interface [polypeptide binding]; other site
929506005647	Putative lysophospholipase; Region: Hydrolase_4; pfam12146
929506005648	Alpha/beta hydrolase family; Region: Abhydrolase_5; pfam12695
929506005649	Prolyl oligopeptidase family; Region: Peptidase_S9; pfam00326
929506005650	Cation transport ATPase [Inorganic ion transport and metabolism]; Region: MgtA; COG0474
929506005651	E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122
929506005652	Soluble P-type ATPase [General function prediction only]; Region: COG4087
929506005653	Cation transporting ATPase, C-terminus; Region: Cation_ATPase_C; pfam00689
929506005654	Transcriptional regulator [Transcription]; Region: LysR; COG0583
929506005655	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
929506005656	C-terminal substrate binding domain of LysR-type transcriptional regulator CysL, which activates the transcription of the cysJI operon encoding sulfite reductase, contains the type 2 periplasmic binding fold; Region: PBP2_CysL_like; cd08420
929506005657	putative dimerization interface [polypeptide binding]; other site
929506005658	Predicted membrane protein [Function unknown]; Region: COG2855
929506005659	MutT homolog-1 (MTH1) is a member of the Nudix hydrolase superfamily. MTH1, the mammalian counterpart of MutT, hydrolyzes oxidized purine nucleoside triphosphates, such as 8-oxo-dGTP and 2-hydroxy-ATP, to monophosphates, thereby preventing the...; Region: MTH1; cd03427
929506005660	putative active site [active]
929506005661	nucleotide binding site [chemical binding]; other site
929506005662	nudix motif; other site
929506005663	putative metal binding site [ion binding]; other site
929506005664	Methyl-accepting chemotaxis protein [Cell motility and secretion / Signal transduction mechanisms]; Region: Tar; COG0840
929506005665	Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225
929506005666	dimerization interface [polypeptide binding]; other site
929506005667	Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386
929506005668	dimer interface [polypeptide binding]; other site
929506005669	putative CheW interface [polypeptide binding]; other site
929506005670	Na+-driven multidrug efflux pump [Defense mechanisms]; Region: NorM; COG0534
929506005671	Uncharacterized subfamily of the multidrug and toxic compound extrusion (MATE) proteins; Region: MATE_like_8; cd13134
929506005672	Type 1 periplasmic binding fold superfamily; Region: Periplasmic_Binding_Protein_Type_1; cl10011
929506005673	PAS domain S-box; Region: sensory_box; TIGR00229
929506005674	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
929506005675	putative active site [active]
929506005676	heme pocket [chemical binding]; other site
929506005677	c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal    transduction mechanisms]; Region: COG2199
929506005678	Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949
929506005679	metal binding site [ion binding]; metal-binding site
929506005680	active site
929506005681	I-site; other site
929506005682	EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2).  The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948
929506005683	PAS domain S-box; Region: sensory_box; TIGR00229
929506005684	c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal    transduction mechanisms]; Region: COG2199
929506005685	Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949
929506005686	metal binding site [ion binding]; metal-binding site
929506005687	active site
929506005688	I-site; other site
929506005689	EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2).  The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948
929506005690	short chain dehydrogenase; Provisional; Region: PRK06701
929506005691	classical (c) SDR, subgroup 1; Region: SDR_c1; cd05355
929506005692	NAD binding site [chemical binding]; other site
929506005693	metal binding site [ion binding]; metal-binding site
929506005694	active site
929506005695	Flavodoxin-like fold; Region: Flavodoxin_2; cl00438
929506005696	solute carrier 6 subfamily, Fusobacterium nucleatum Tyt1-like; solute-binding domain; Region: SLC6sbd_Tyt1-Like; cd10336
929506005697	Na2 binding site [ion binding]; other site
929506005698	putative substrate binding site 1 [chemical binding]; other site
929506005699	Na binding site 1 [ion binding]; other site
929506005700	putative substrate binding site 2 [chemical binding]; other site
929506005701	Protein of unknown function (DUF2752); Region: DUF2752; pfam10825
929506005702	Domain of unknown function (DUF4234); Region: DUF4234; pfam14018
929506005703	5TMR of 5TMR-LYT; Region: 5TM-5TMR_LYT; pfam07694
929506005704	Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer); Region: MA; smart00283
929506005705	Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386
929506005706	dimer interface [polypeptide binding]; other site
929506005707	putative CheW interface [polypeptide binding]; other site
929506005708	Repair protein; Region: Repair_PSII; pfam04536
929506005709	LemA family; Region: LemA; cl00742
929506005710	Predicted secreted protein [Function unknown]; Region: COG4086
929506005711	Protein of unknown function (DUF1002); Region: DUF1002; pfam06207
929506005712	Multimeric flavodoxin WrbA [General function prediction only]; Region: WrbA; COG0655
929506005713	NADPH-dependent FMN reductase; Region: FMN_red; pfam03358
929506005714	Domain of unknown function (DUF1835); Region: DUF1835; pfam08874
929506005715	Protein of unknown function; Region: DUF3658; pfam12395
929506005716	lysine transporter; Provisional; Region: PRK10836
929506005717	DEAD-box helicases. A diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker  B motif; Region: DEADc; cd00268
929506005718	DEAD-like helicases superfamily; Region: DEXDc; smart00487
929506005719	ATP binding site [chemical binding]; other site
929506005720	Mg++ binding site [ion binding]; other site
929506005721	motif III; other site
929506005722	Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079
929506005723	nucleotide binding region [chemical binding]; other site
929506005724	ATP-binding site [chemical binding]; other site
929506005725	Cold-Shock Protein (CSP) contains an S1-like cold-shock domain (CSD) that is found in eukaryotes, prokaryotes, and archaea.  CSP's include the major cold-shock proteins CspA and CspB in bacteria and the eukaryotic gene regulatory factor Y-box...; Region: CSP_CDS; cd04458
929506005726	DNA-binding site [nucleotide binding]; DNA binding site
929506005727	RNA-binding motif; other site
929506005728	Cache domain; Region: Cache_1; pfam02743
929506005729	Methyl-accepting chemotaxis protein [Cell motility and secretion / Signal transduction mechanisms]; Region: Tar; COG0840
929506005730	Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cl01054
929506005731	dimerization interface [polypeptide binding]; other site
929506005732	Subfamily of the multidrug and toxic compound extrusion (MATE)-like proteins similar to Streptococcus aureus MepA; Region: MATE_MepA_like; cd13143
929506005733	putative efflux protein, MATE family; Region: matE; TIGR00797
929506005734	Predicted integral membrane protein [Function unknown]; Region: COG5652
929506005735	Membrane-associated lipoprotein involved in thiamine biosynthesis [Coenzyme metabolism]; Region: ApbE; COG1477
929506005736	ApbE family; Region: ApbE; pfam02424
929506005737	Protein of unknown function (DUF1533); Region: DUF1533; pfam07550
929506005738	Protein of unknown function (DUF1533); Region: DUF1533; pfam07550
929506005739	Protein of unknown function (DUF1533); Region: DUF1533; pfam07550
929506005740	Protein of unknown function (DUF1533); Region: DUF1533; pfam07550
929506005741	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3677
929506005742	ISCb1g3, transposase
929506005743	GrpE is the adenine nucleotide exchange factor of DnaK (Hsp70)-type ATPases. The GrpE dimer binds to the ATPase domain of Hsp70 catalyzing the dissociation of ADP, which enables rebinding of ATP, one step in the Hsp70 reaction cycle in protein folding; Region: GrpE; cd00446
929506005744	hsp70 (ATPase domain) interactions [polypeptide binding]; other site
929506005745	Transposase domain (DUF772); Region: DUF772; pfam05598
929506005746	Transposase DDE domain; Region: DDE_Tnp_1_6; pfam13751
929506005747	dihydropyrimidine dehydrogenase subunit B; Validated; Region: PRK08318
929506005748	Dihydropyrimidine dehydrogenase (DHPD) FMN-binding domain.  DHPD catalyzes the first step in pyrimidine degradation: the NADPH-dependent reduction of uracil and thymine to the corresponding 5,6-dihydropyrimidines. DHPD contains two FAD, two FMN, and...; Region: DHPD_FMN; cd02940
929506005749	homodimer interface [polypeptide binding]; other site
929506005750	active site
929506005751	FMN binding site [chemical binding]; other site
929506005752	substrate binding site [chemical binding]; other site
929506005753	4Fe-4S binding domain; Region: Fer4; cl02805
929506005754	4Fe-4S binding domain; Region: Fer4; pfam00037
929506005755	dihydropyrimidine dehydrogenase subunit A; Provisional; Region: PRK11749
929506005756	NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450
929506005757	ribonuclease Z; Reviewed; Region: PRK00055
929506005758	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3677
929506005759	InsA N-terminal domain; Region: Zn_Tnp_IS1; pfam03811
929506005760	DDE domain; Region: DDE_Tnp_IS240; pfam13610
929506005761	Integrase core domain; Region: rve; pfam00665
929506005762	Integrase core domain; Region: rve_3; pfam13683
929506005763	benzoyl-CoA reductase, subunit C; Region: benz_CoA_red_C; TIGR02263
929506005764	2-hydroxyglutaryl-CoA dehydratase, D-component; Region: HGD-D; pfam06050
929506005765	2-hydroxyglutaryl-CoA dehydratase, D-component; Region: HGD-D; pfam06050
929506005766	benzoyl-CoA reductase, bcr type, subunit B; Region: benz_CoA_red_B; TIGR02260
929506005767	BadF/BadG/BcrA/BcrD ATPase family; Region: BcrAD_BadFG; cl17271
929506005768	Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903
929506005769	Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase_4; pfam13669
929506005770	active site
929506005771	metal binding site [ion binding]; metal-binding site
929506005772	Acyl CoA:acetate/3-ketoacid CoA transferase [Lipid metabolism]; Region: COG4670
929506005773	Coenzyme A transferase; Region: CoA_trans; smart00882
929506005774	Coenzyme A transferase; Region: CoA_trans; cl17247
929506005775	PTS_IIA, PTS system, mannose/sorbose specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIA_man; cl00025
929506005776	active pocket/dimerization site; other site
929506005777	active site
929506005778	phosphorylation site [posttranslational modification]
929506005779	PTS system mannose/fructose/sorbose family IID component; Region: EIID-AGA; pfam03613
929506005780	PTS system sorbose-specific iic component; Region: EII-Sor; pfam03609
929506005781	PTS_IIB, PTS system, Mannose/sorbose specific IIB subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIB_man; cd00001
929506005782	active site
929506005783	phosphorylation site [posttranslational modification]
929506005784	Glycosyl Hydrolase Family 88; Region: Glyco_hydro_88; pfam07470
929506005785	LanC-like proteins. LanC is the cyclase enzyme of the lanthionine synthetase. Lanthionine is a lantibiotic, a unique class of peptide antibiotics. They are ribosomally synthesized as a precursor peptide and then post-translationally modified to contain...; Region: LanC_like; cl04955
929506005786	Alphavirus core protein; Region: Peptidase_S3; pfam00944
929506005787	Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697
929506005788	helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342
929506005789	thioredoxin-disulfide reductase; Region: TRX_reduct; TIGR01292
929506005790	NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500
929506005791	Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070
929506005792	NrdH-redoxin (NrdH) family; NrdH is a small monomeric protein with a conserved redox active CXXC motif within a TRX fold, characterized by a glutaredoxin (GRX)-like sequence and TRX-like activity profile. In vitro, it displays protein disulfide reductase...; Region: NrdH; cd02976
929506005793	catalytic residues [active]
929506005794	ABC-type cobalamin/Fe3+-siderophores transport systems, ATPase components [Inorganic ion transport and metabolism / Coenzyme metabolism]; Region: FepC; COG1120
929506005795	ATP-binding component of iron-siderophores, vitamin B12 and hemin transporters and related proteins; Region: ABC_Iron-Siderophores_B12_Hemin; cd03214
929506005796	Walker A/P-loop; other site
929506005797	ATP binding site [chemical binding]; other site
929506005798	Q-loop/lid; other site
929506005799	ABC transporter signature motif; other site
929506005800	Walker B; other site
929506005801	D-loop; other site
929506005802	H-loop/switch region; other site
929506005803	Predicted permeases [General function prediction only]; Region: COG0679
929506005804	Domain of unknown function DUF11; Region: DUF11; cl17728
929506005805	Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093
929506005806	non-specific DNA binding site [nucleotide binding]; other site
929506005807	salt bridge; other site
929506005808	sequence-specific DNA binding site [nucleotide binding]; other site
929506005809	Mannose-6-phosphate isomerase [Carbohydrate transport and metabolism]; Region: {ManC}; COG0662
929506005810	Acetyltransferase (GNAT) domain; Region: Acetyltransf_8; pfam13523
929506005811	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301
929506005812	Coenzyme A binding pocket [chemical binding]; other site
929506005813	ABC-type Na+ efflux pump, permease component [Energy production and conversion / Inorganic ion transport and metabolism]; Region: NatB; COG1668
929506005814	ABC-type uncharacterized transport system, ATPase component [General function prediction only]; Region: COG4152
929506005815	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
929506005816	Walker A/P-loop; other site
929506005817	ATP binding site [chemical binding]; other site
929506005818	Q-loop/lid; other site
929506005819	ABC transporter signature motif; other site
929506005820	Walker B; other site
929506005821	D-loop; other site
929506005822	H-loop/switch region; other site
929506005823	Transcriptional regulator [Transcription]; Region: AcrR; COG1309
929506005824	Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440
929506005825	YsiA-like protein, C-terminal region; Region: TetR_C_4; pfam08359
929506005826	NADH:flavin oxidoreductases, Old Yellow Enzyme family [Energy production and conversion]; Region: NemA; COG1902
929506005827	Enoate reductase (ER)-like FMN-binding domain. Enoate reductase catalyzes the NADH-dependent reduction of carbon-carbon double bonds of several molecules, including nonactivated 2-enoates, alpha,beta-unsaturated aldehydes, cyclic ketones, and...; Region: ER_like_FMN; cd02931
929506005828	putative active site [active]
929506005829	putative FMN binding site [chemical binding]; other site
929506005830	putative substrate binding site [chemical binding]; other site
929506005831	putative catalytic residue [active]
929506005832	putative 4Fe-4S cluster binding site [ion binding]; other site
929506005833	Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox_2; pfam07992
929506005834	Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070
929506005835	NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500
929506005836	Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070
929506005837	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301
929506005838	Coenzyme A binding pocket [chemical binding]; other site
929506005839	Trypsin-like serine protease; Many of these are synthesized as inactive precursor zymogens that are cleaved during limited proteolysis to generate their active forms. Alignment contains also inactive enzymes that have substitutions of the catalytic triad...; Region: Tryp_SPc; cl00149
929506005840	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
929506005841	putative substrate translocation pore; other site
929506005842	Major Facilitator Superfamily; Region: MFS_1; pfam07690
929506005843	helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347
929506005844	MarR family; Region: MarR; pfam01047
929506005845	Carbon dioxide concentrating mechanism/carboxysome shell protein [Secondary metabolites biosynthesis, transport, and catabolism / Energy production and conversion]; Region: CcmK; COG4577
929506005846	1,2-propanediol utilization protein A (PduA), Bacterial Micro-Compartment (BMC) domain; Region: BMC_PduA; cd07059
929506005847	Hexamer interface [polypeptide binding]; other site
929506005848	Putative hexagonal pore residue; other site
929506005849	propanediol utilization phosphotransacylase; Provisional; Region: PRK15070
929506005850	Propanediol utilisation protein PduL; Region: PduL; pfam06130
929506005851	Propanediol utilisation protein PduL; Region: PduL; pfam06130
929506005852	NAD-dependent aldehyde dehydrogenases [Energy production and conversion]; Region: PutA; COG1012
929506005853	Coenzyme A acylating aldehyde dehydrogenase (ACDH), ALDH family 20-like; Region: ALDH_F20_ACDH; cd07122
929506005854	putative catalytic cysteine [active]
929506005855	ethanolamine utilization protein EutQ; Provisional; Region: PRK15457
929506005856	Ethanolamine utilization protein [Amino acid transport and metabolism]; Region: EutQ; COG4766
929506005857	Ethanolamine utilisation protein and carboxysome structural protein domain family; Region: EutN_CcmL; cd01614
929506005858	Hexamer/Pentamer interface [polypeptide binding]; other site
929506005859	central pore; other site
929506005860	ethanolamine utilization protein EutJ; Provisional; Region: PRK15080
929506005861	Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cd00012
929506005862	nucleotide binding site [chemical binding]; other site
929506005863	Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cl17037
929506005864	Cobalamin adenosyltransferase; Region: Cob_adeno_trans; cl00920
929506005865	Rat sarcoma (Ras)-like superfamily of small guanosine triphosphatases (GTPases); Region: Ras_like_GTPase; cd00882
929506005866	G1 box; other site
929506005867	GTP/Mg2+ binding site [chemical binding]; other site
929506005868	G2 box; other site
929506005869	Switch I region; other site
929506005870	G3 box; other site
929506005871	Switch II region; other site
929506005872	G4 box; other site
929506005873	G5 box; other site
929506005874	1,2-propanediol utilization protein U (PduU)/ethanolamine utilization protein S (EutS), Bacterial Micro-Compartment (BMC) domain; Region: BMC_PduU-EutS; cd07046
929506005875	putative hexamer interface [polypeptide binding]; other site
929506005876	putative hexagonal pore; other site
929506005877	glycyl-radical enzyme activating protein family; Region: PFLE_PFLC; TIGR02494
929506005878	RPB11 and RPB3 subunits of RNA polymerase; Region: RNAP_RPB11_RPB3; cl11409
929506005879	glycyl radical enzyme, PFL2/glycerol dehydratase family; Region: PFL2-3; TIGR01774
929506005880	Pyruvate formate lyase 2 and related enzymes; Region: PFL2_DhaB_BssA; cd01677
929506005881	dimer interface [polypeptide binding]; other site
929506005882	active site
929506005883	glycine loop; other site
929506005884	Coenzyme A acylating aldehyde dehydrogenase (ACDH), ALDH family 20-like; Region: ALDH_F20_ACDH; cd07122
929506005885	putative catalytic cysteine [active]
929506005886	Carbon dioxide concentrating mechanism/carboxysome shell protein [Secondary metabolites biosynthesis, transport, and catabolism / Energy production and conversion]; Region: CcmK; COG4577
929506005887	Carbon dioxide concentrating mechanism K (CcmK)-like proteins, Bacterial Micro-Compartment (BMC) domain; Region: BMC_CcmK_like; cd07045
929506005888	Hexamer interface [polypeptide binding]; other site
929506005889	Hexagonal pore residue; other site
929506005890	Carbon dioxide concentrating mechanism/carboxysome shell protein [Secondary metabolites biosynthesis, transport, and catabolism / Energy production and conversion]; Region: CcmK; COG4577
929506005891	Carbon dioxide concentrating mechanism K (CcmK)-like proteins, Bacterial Micro-Compartment (BMC) domain; Region: BMC_CcmK_like; cd07045
929506005892	Hexamer interface [polypeptide binding]; other site
929506005893	Hexagonal pore residue; other site
929506005894	Transcriptional regulator PadR-like family; Region: PadR; cl17335
929506005895	Multidrug resistance efflux transporter; Region: EmrE; pfam13536
929506005896	Predicted transcriptional regulators [Transcription]; Region: SoxR; COG0789
929506005897	Helix-Turn-Helix DNA binding domain of the BmrR transcription regulator; Region: HTH_BmrR; cd01107
929506005898	DNA binding residues [nucleotide binding]
929506005899	drug binding residues [chemical binding]; other site
929506005900	dimer interface [polypeptide binding]; other site
929506005901	Alcohol dehydrogenase, class IV [Energy production and conversion]; Region: EutG; COG1454
929506005902	1,3-propanediol dehydrogenase (PPD) catalyzes the reduction of 3-hydroxypropionaldehyde (3-HPA) to 1,3-propanediol in glycerol metabolism; Region: PDD; cd08180
929506005903	putative active site [active]
929506005904	metal binding site [ion binding]; metal-binding site
929506005905	Highly conserved protein containing a thioredoxin domain [Posttranslational modification, protein turnover, chaperones]; Region: COG1331
929506005906	TRX domain, SSP411 protein family; members of this family are highly conserved proteins present in eukaryotes, bacteria and archaea, about 600-800 amino acids in length, which contain a TRX domain with a redox active CXXC motif. The human/rat protein; Region: SSP411; cd02955
929506005907	catalytic residues [active]
929506005908	LanC-like proteins. LanC is the cyclase enzyme of the lanthionine synthetase. Lanthionine is a lantibiotic, a unique class of peptide antibiotics. They are ribosomally synthesized as a precursor peptide and then post-translationally modified to contain...; Region: LanC_like; cl04955
929506005909	active site
929506005910	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3677
929506005911	InsA N-terminal domain; Region: Zn_Tnp_IS1; pfam03811
929506005912	DDE domain; Region: DDE_Tnp_IS240; pfam13610
929506005913	Integrase core domain; Region: rve; pfam00665
929506005914	Integrase core domain; Region: rve_3; pfam13683
929506005915	Subfamily of the multidrug and toxic compound extrusion (MATE)-like proteins similar to Bacillus subtilis yoeA; Region: MATE_yoeA_like; cd13138
929506005916	Na+-driven multidrug efflux pump [Defense mechanisms]; Region: NorM; COG0534
929506005917	Transcriptional regulator [Transcription]; Region: AcrR; COG1309
929506005918	Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440
929506005919	Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392
929506005920	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG4584
929506005921	DNA binding site [nucleotide binding]
929506005922	Integrase core domain; Region: rve; pfam00665
929506005923	transposase/IS protein; Provisional; Region: PRK09183
929506005924	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
929506005925	Walker A motif; other site
929506005926	ATP binding site [chemical binding]; other site
929506005927	Walker B motif; other site
929506005928	arginine finger; other site
929506005929	Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093
929506005930	non-specific DNA binding site [nucleotide binding]; other site
929506005931	salt bridge; other site
929506005932	sequence-specific DNA binding site [nucleotide binding]; other site
929506005933	SAM-dependent methyltransferases related to tRNA (uracil-5-)-methyltransferase [Translation, ribosomal structure and biogenesis]; Region: TrmA; COG2265
929506005934	Metallo-beta-lactamase superfamily; Region: Lactamase_B; smart00849
929506005935	Escherichia coli YfcE and related proteins, metallophosphatase domain; Region: MPP_YfcE; cd00841
929506005936	Calcineurin-like phosphoesterase; Region: Metallophos; pfam00149
929506005937	active site
929506005938	metal binding site [ion binding]; metal-binding site
929506005939	homotetramer interface [polypeptide binding]; other site
929506005940	Xanthine/uracil/vitamin C permease [Nucleotide transport and    metabolism]; Region: COG2252
929506005941	phosphoribosylamine--glycine ligase; Provisional; Region: PRK00885
929506005942	Phosphoribosylglycinamide synthetase, N domain; Region: GARS_N; pfam02844
929506005943	Phosphoribosylglycinamide synthetase, ATP-grasp (A) domain; Region: GARS_A; pfam01071
929506005944	Phosphoribosylglycinamide synthetase, C domain; Region: GARS_C; pfam02843
929506005945	phosphoribosylformylglycinamidine synthase, clade II; Region: FGAM-synthase; TIGR01857
929506005946	AIR (aminoimidazole ribonucleotide) synthase related protein. This family includes Hydrogen expression/formation protein HypE, AIR synthases, FGAM (formylglycinamidine ribonucleotide) synthase and Selenophosphate synthetase (SelD). The N-terminal domain...; Region: PurM-like; cl10019
929506005947	PurL subunit of the formylglycinamide ribonucleotide amidotransferase (FGAR-AT), first repeat. FGAR-AT catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to formylglycinamidine ribonucleotide (FGAM), ADP; Region: PurL_repeat1; cd02203
929506005948	dimerization interface [polypeptide binding]; other site
929506005949	ATP binding site [chemical binding]; other site
929506005950	PurL subunit of the formylglycinamide ribonucleotide amidotransferase (FGAR-AT), second repeat. FGAR-AT catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to formylglycinamidine ribonucleotide (FGAM), ADP; Region: PurL_repeat2; cd02204
929506005951	dimerization interface [polypeptide binding]; other site
929506005952	ATP binding site [chemical binding]; other site
929506005953	Type 1 glutamine amidotransferase (GATase1)-like domain found in Formylglycinamide ribonucleotide amidotransferase; Region: GATase1_FGAR_AT; cd01740
929506005954	putative active site [active]
929506005955	catalytic triad [active]
929506005956	bifunctional phosphoribosylaminoimidazolecarboxamide formyltransferase/IMP cyclohydrolase; Provisional; Region: purH; PRK00881
929506005957	Inosine monophosphate cyclohydrolase domain. This is the N-terminal domain in the purine biosynthesis pathway protein ATIC (purH). The bifunctional ATIC protein contains a C-terminal  ATIC formylase domain that formylates...; Region: IMPCH; cd01421
929506005958	purine monophosphate binding site [chemical binding]; other site
929506005959	dimer interface [polypeptide binding]; other site
929506005960	putative catalytic residues [active]
929506005961	AICARFT/IMPCHase bienzyme; Region: AICARFT_IMPCHas; smart00798
929506005962	AICARFT/IMPCHase bienzyme; Region: AICARFT_IMPCHas; cl03362
929506005963	phosphoribosylglycinamide formyltransferase; Reviewed; Region: purN; PRK05647
929506005964	Phosphoribosylglycinamide formyltransferase (GAR transformylase, GART); Region: FMT_core_GART; cd08645
929506005965	active site
929506005966	substrate binding site [chemical binding]; other site
929506005967	cosubstrate binding site; other site
929506005968	catalytic site [active]
929506005969	phosphoribosylaminoimidazole synthetase; Provisional; Region: PRK05385
929506005970	PurM (Aminoimidazole Ribonucleotide [AIR] synthetase), one of eleven enzymes required for purine biosynthesis, catalyzes the conversion of formylglycinamide ribonucleotide (FGAM) and ATP to AIR, ADP, and Pi, the fifth step in de novo purine biosynthesis; Region: PurM; cd02196
929506005971	dimerization interface [polypeptide binding]; other site
929506005972	putative ATP binding site [chemical binding]; other site
929506005973	amidophosphoribosyltransferase; Provisional; Region: PRK05793
929506005974	Glutamine amidotransferases class-II (GN-AT)_GPAT- type. This domain is found at the N-terminus of  glutamine phosphoribosylpyrophosphate (Prpp) amidotransferase (GPATase) . The glutaminase domain catalyzes amide nitrogen transfer from glutamine to the...; Region: GPATase_N; cd00715
929506005975	active site
929506005976	tetramer interface [polypeptide binding]; other site
929506005977	Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223
929506005978	active site
929506005979	phosphoribosylaminoimidazole-succinocarboxamide synthase; Reviewed; Region: PRK09362
929506005980	bacterial and archaeal 5-aminoimidazole-4-(N-succinylcarboxamide) ribonucleotide (SAICAR) synthase; Region: SAICAR_synt_PurC; cd01415
929506005981	ATP binding site [chemical binding]; other site
929506005982	active site
929506005983	substrate binding site [chemical binding]; other site
929506005984	Phosphoribosylcarboxyaminoimidazole (NCAIR) mutase [Nucleotide transport and metabolism]; Region: PurE; COG0041
929506005985	Na+/alanine symporter [Amino acid transport and metabolism]; Region: AlsT; COG1115
929506005986	amino acid carrier protein; Region: agcS; TIGR00835
929506005987	hypothetical protein; Provisional; Region: PRK09609
929506005988	Protein of unknown function (DUF3816); Region: DUF3816; pfam12822
929506005989	Predicted membrane protein [Function unknown]; Region: COG4684
929506005990	Protein of unknown function (DUF3816); Region: DUF3816; pfam12822
929506005991	Branched-chain amino acid transport protein; Region: Branch_AA_trans; cl00547
929506005992	Fe2+ transport system protein B [Inorganic ion transport and metabolism]; Region: FeoB; COG0370
929506005993	Ferrous iron transport protein B (FeoB) family; Region: FeoB; cd01879
929506005994	G1 box; other site
929506005995	GTP/Mg2+ binding site [chemical binding]; other site
929506005996	Switch I region; other site
929506005997	G2 box; other site
929506005998	G3 box; other site
929506005999	Switch II region; other site
929506006000	G4 box; other site
929506006001	G5 box; other site
929506006002	Nucleoside recognition; Region: Gate; pfam07670
929506006003	Ferrous iron transport protein B C terminus; Region: FeoB_C; pfam07664
929506006004	Nucleoside recognition; Region: Gate; pfam07670
929506006005	Fe2+ transport system protein A [Inorganic ion transport and metabolism]; Region: FeoA; COG1918
929506006006	Fe2+ transport system protein A [Inorganic ion transport and metabolism]; Region: FeoA; COG1918
929506006007	ABC-2 family transporter protein; Region: ABC2_membrane_5; pfam13346
929506006008	ABC-2 family transporter protein; Region: ABC2_membrane_5; pfam13346
929506006009	ABC-type multidrug transport system, ATPase component [Defense mechanisms]; Region: CcmA; COG1131
929506006010	ATP-binding cassette domain of the drug resistance transporter and related proteins, subfamily A; Region: ABC_DR_subfamily_A; cd03230
929506006011	Walker A/P-loop; other site
929506006012	ATP binding site [chemical binding]; other site
929506006013	Q-loop/lid; other site
929506006014	ABC transporter signature motif; other site
929506006015	Walker B; other site
929506006016	D-loop; other site
929506006017	H-loop/switch region; other site
929506006018	Predicted transcriptional regulators [Transcription]; Region: COG1725
929506006019	Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377
929506006020	DNA-binding site [nucleotide binding]; DNA binding site
929506006021	Protein of unknown function (DUF3793); Region: DUF3793; pfam12672
929506006022	Domain of unknown function (DUF1287); Region: DUF1287; cl01519
929506006023	Protein of unknown function (DUF1097); Region: DUF1097; pfam06496
929506006024	InsA N-terminal domain; Region: Zn_Tnp_IS1; pfam03811
929506006025	DDE domain; Region: DDE_Tnp_IS240; pfam13610
929506006026	Integrase core domain; Region: rve; pfam00665
929506006027	Integrase core domain; Region: rve_3; pfam13683
929506006028	histidinol-phosphatase; Provisional; Region: PRK05588
929506006029	Polymerase and Histidinol Phosphatase domain; Region: PHP; cl17102
929506006030	active site
929506006031	N-acetylmuramoyl-L-alanine amidase or MurNAc-LAA (also known as peptidoglycan aminohydrolase, NAMLA amidase, NAMLAA, Amidase 3, and peptidoglycan amidase; EC 3.5.1.28) is an autolysin that hydrolyzes the amide bond between N-acetylmuramoyl and L-amino...; Region: MurNAc-LAA; cd02696
929506006032	active site
929506006033	metal binding site [ion binding]; metal-binding site
929506006034	Bacterial SH3 domain; Region: SH3_3; pfam08239
929506006035	Domain of unknown function (DUF4300); Region: DUF4300; pfam14133
929506006036	Cysteine-rich 4 helical bundle widely conserved in bacteria; Region: DUF326; cd08026
929506006037	dimerization interface [polypeptide binding]; other site
929506006038	Multidrug resistance efflux transporter; Region: EmrE; pfam13536
929506006039	DNA-binding transcriptional repressor PuuR; Provisional; Region: PRK09943
929506006040	Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093
929506006041	non-specific DNA binding site [nucleotide binding]; other site
929506006042	salt bridge; other site
929506006043	sequence-specific DNA binding site [nucleotide binding]; other site
929506006044	Cupin domain; Region: Cupin_2; pfam07883
929506006045	Trypsin-like serine protease; Many of these are synthesized as inactive precursor zymogens that are cleaved during limited proteolysis to generate their active forms. Alignment contains also inactive enzymes that have substitutions of the catalytic triad...; Region: Tryp_SPc; cl00149
929506006046	Uncharacterized protein family (UPF0157); Region: UPF0157; pfam04229
929506006047	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301
929506006048	Coenzyme A binding pocket [chemical binding]; other site
929506006049	Microcin C7 self-immunity protein determines resistance to exogenous microcin C7; Region: Peptidase_S66_mccF_like; cd07062
929506006050	putative dimer interface [polypeptide binding]; other site
929506006051	catalytic triad [active]
929506006052	Protein of unknown function (DUF2809); Region: DUF2809; pfam10990
929506006053	Acetyltransferases, including N-acetylases of ribosomal proteins [Translation, ribosomal structure and biogenesis]; Region: RimL; COG1670
929506006054	DNA polymerase IV; Provisional; Region: PRK14133
929506006055	DNA Polymerase IV/Kappa; Region: PolY_Pol_IV_kappa; cd03586
929506006056	active site
929506006057	DNA binding site [nucleotide binding]
929506006058	formate acetyltransferase 1; Region: pyr_form_ly_1; TIGR01255
929506006059	Pyruvate formate lyase 1; Region: PFL1; cd01678
929506006060	coenzyme A binding site [chemical binding]; other site
929506006061	active site
929506006062	catalytic residues [active]
929506006063	glycine loop; other site
929506006064	pyruvate formate-lyase 1-activating enzyme; Region: PFLA; TIGR02493
929506006065	Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335
929506006066	FeS/SAM binding site; other site
929506006067	SdpI/YhfL protein family; Region: SdpI; pfam13630
929506006068	NhaP-type Na+/H+ and K+/H+ antiporters [Inorganic ion transport and metabolism]; Region: NhaP; COG0025
929506006069	Kef-type K+ transport systems, membrane components [Inorganic ion transport and metabolism]; Region: KefB; cl10482
929506006070	Peptidase S8 family domain in Streptococcal C5a peptidases; Region: Peptidases_S8_C5a_Peptidase; cd07475
929506006071	putative active site [active]
929506006072	catalytic triad [active]
929506006073	Peptidase S8 family domain in Streptococcal C5a peptidases; Region: Peptidases_S8_C5a_Peptidase; cd07475
929506006074	putative active site [active]
929506006075	Subtilisin-like serine proteases [Posttranslational modification, protein turnover, chaperones]; Region: AprE; COG1404
929506006076	Fn3-like domain (DUF1034); Region: DUF1034; pfam06280
929506006077	FlgD Tudor-like domain; Region: FLgD_tudor; pfam13861
929506006078	Glycosyl hydrolase families: GH43, GH62, GH32, GH68; Region: GH43_62_32_68; cl14647
929506006079	Cache domain; Region: Cache_1; pfam02743
929506006080	Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer); Region: MA; smart00283
929506006081	Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386
929506006082	dimer interface [polypeptide binding]; other site
929506006083	putative CheW interface [polypeptide binding]; other site
929506006084	potential frameshift: common BLAST hit: gi|110798789|ref|YP_694863.1| heparinase II/III-like protein
929506006085	Alginate Lyase A1-III; enzymatically depolymerizes alginate, a complex copolymer of beta-D-mannuronate and alpha-L-guluronate, by cleaving the beta-(1,4) glycosidic bond; Region: AlgLyase; cl00179
929506006086	Heparinase II/III-like protein; Region: Hepar_II_III; pfam07940
929506006087	Transposase, Mutator family; Region: Transposase_mut; pfam00872
929506006088	MULE transposase domain; Region: MULE; pfam10551
929506006089	Protein of unknown function DUF45; Region: DUF45; pfam01863
929506006090	Uncharacterized conserved protein [Function unknown]; Region: COG0327
929506006091	NIF3 (NGG1p interacting factor 3); Region: NIF3; pfam01784
929506006092	Predicted SAM-dependent methyltransferase [General function prediction only]; Region: COG2384
929506006093	Family of unknown function (DUF633); Region: DUF633; pfam04816
929506006094	Protein of unknown function (DUF2679); Region: DUF2679; pfam10882
929506006095	RNA polymerase sigma factor RpoD; Validated; Region: PRK09210
929506006096	Sigma-70 factor, region 1.1; Region: Sigma70_r1_1; pfam03979
929506006097	Sigma-70 factor, region 1.2; Region: Sigma70_r1_2; pfam00140
929506006098	Sigma-70 region 2; Region: Sigma70_r2; pfam04542
929506006099	Sigma-70 region 3; Region: Sigma70_r3; pfam04539
929506006100	Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171
929506006101	DNA binding residues [nucleotide binding]
929506006102	DNA primase, catalytic core; Region: dnaG; TIGR01391
929506006103	CHC2 zinc finger; Region: zf-CHC2; pfam01807
929506006104	DNA primase catalytic core, N-terminal domain; Region: Toprim_N; pfam08275
929506006105	TOPRIM_DnaG_primases: The topoisomerase-primase (TORPIM) nucleotidyl transferase/hydrolase domain found in the active site regions of proteins similar to Escherichia coli DnaG. Primases synthesize RNA primers for the initiation of DNA replication. DnaG...; Region: TOPRIM_DnaG_primases; cd03364
929506006106	active site
929506006107	metal binding site [ion binding]; metal-binding site
929506006108	interdomain interaction site; other site
929506006109	DnaB-helicase binding domain of primase; Region: DnaB_bind; pfam10410
929506006110	spore coat protein YsxE; Region: spore_ysxE; TIGR02904
929506006111	spore coat protein, CotS family; Region: spore_CotS; TIGR02906
929506006112	FOG: CBS domain [General function prediction only]; Region: COG0517
929506006113	The CBS domain, named after human CBS, is a small domain originally identified in cystathionine beta-synthase and is subsequently found in a wide range of different proteins. CBS domains usually occur in tandem repeats. They associate to form a so-called...; Region: CBS_pair_4; cd04617
929506006114	SIS domain. SIS (Sugar ISomerase) domains are found in many phosphosugar isomerases and phosphosugar binding proteins. SIS domains are also found in proteins that regulate the expression of genes involved in synthesis of phosphosugars; Region: SIS; cl00389
929506006115	Domain of unknown function (DUF4342); Region: DUF4342; pfam14242
929506006116	DNA repair protein RecO; Reviewed; Region: recO; PRK00085
929506006117	Recombination protein O N terminal; Region: RecO_N; pfam11967
929506006118	Recombination protein O C terminal; Region: RecO_C; pfam02565
929506006119	GTPase Era; Reviewed; Region: era; PRK00089
929506006120	E. coli Ras-like protein (Era) is a multifunctional GTPase; Region: Era; cd04163
929506006121	G1 box; other site
929506006122	GTP/Mg2+ binding site [chemical binding]; other site
929506006123	Switch I region; other site
929506006124	G2 box; other site
929506006125	Switch II region; other site
929506006126	G3 box; other site
929506006127	G4 box; other site
929506006128	G5 box; other site
929506006129	KH domain; Region: KH_2; pfam07650
929506006130	Cytidine deaminase zinc-binding domain. These enzymes are Zn dependent. The zinc ion in the active site plays a central role in the proposed catalytic mechanism, activating a water molecule to form a hydroxide ion that performs a nucleophilic attack on...; Region: cytidine_deaminase; cd01283
929506006131	active site
929506006132	catalytic motif [active]
929506006133	Zn binding site [ion binding]; other site
929506006134	Prokaryotic diacylglycerol kinase; Region: DAGK_prokar; pfam01219
929506006135	Membrane-associated phospholipid phosphatase [Lipid metabolism]; Region: PgpB; COG0671
929506006136	PAP2_like proteins, diacylglycerol_kinase like sub-family. In some prokaryotes, PAP2_like phosphatase domains appear fused to E. coli DAGK-like trans-membrane diacylglycerol kinase domains. The cellular function of these architectures remains to be...; Region: PAP2_diacylglycerolkinase; cd03383
929506006137	active site
929506006138	metal-binding heat shock protein; Provisional; Region: PRK00016
929506006139	Predicted membrane-associated HD superfamily hydrolase [General function prediction only]; Region: COG1480
929506006140	7TM receptor with intracellular HD hydrolase; Region: 7TM-7TMR_HD; pfam07698
929506006141	Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077
929506006142	Zn2+ binding site [ion binding]; other site
929506006143	Mg2+ binding site [ion binding]; other site
929506006144	Putative stage IV sporulation protein YqfD; Region: YqfD; pfam06898
929506006145	sporulation protein YqfD; Region: spore_yqfD; TIGR02876
929506006146	YabP family; Region: YabP; cl06766
929506006147	Yqey-like protein; Region: YqeY; pfam09424
929506006148	30S ribosomal protein S21; Reviewed; Region: rpsU; PRK00270
929506006149	Protein Kinase C Interacting protein related (PKCI): PKCI and related proteins belong to the ubiquitous HIT family of hydrolases that act on alpha-phosphates of ribonucleotides. The members of this subgroup have a conserved HxHxHxx motif (x is a...; Region: PKCI_related; cd01276
929506006150	nucleotide binding site/active site [active]
929506006151	HIT family signature motif; other site
929506006152	catalytic residue [active]
929506006153	2-methylthioadenine synthetase [Translation, ribosomal structure and biogenesis]; Region: MiaB; COG0621
929506006154	Uncharacterized protein family UPF0004; Region: UPF0004; pfam00919
929506006155	Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335
929506006156	FeS/SAM binding site; other site
929506006157	16S ribosomal RNA methyltransferase RsmE; Provisional; Region: PRK11713
929506006158	RNA methyltransferase, RsmE family; Region: TIGR00046
929506006159	Ribosomal protein L11 methyltransferase (PrmA); Region: PrmA; pfam06325
929506006160	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
929506006161	S-adenosylmethionine binding site [chemical binding]; other site
929506006162	chaperone protein DnaJ; Provisional; Region: PRK14297
929506006163	DnaJ domain or J-domain.  DnaJ/Hsp40 (heat shock protein 40) proteins are highly conserved and play crucial roles in protein translation, folding, unfolding, translocation, and degradation. They act primarily by stimulating the ATPase activity of Hsp70s; Region: DnaJ; cd06257
929506006164	HSP70 interaction site [polypeptide binding]; other site
929506006165	C-terminal substrate binding domain of DnaJ and HSP40; Region: DnaJ_C; cl03262
929506006166	substrate binding site [polypeptide binding]; other site
929506006167	Zinc finger domain of DnaJ and HSP40; Region: DnaJ_zf; cd10719
929506006168	Zn binding sites [ion binding]; other site
929506006169	C-terminal substrate binding domain of DnaJ and HSP40; Region: DnaJ_C; cd10747
929506006170	dimer interface [polypeptide binding]; other site
929506006171	molecular chaperone DnaK; Provisional; Region: dnaK; PRK00290
929506006172	Nucleotide-binding domain of human HSPA9 and similar proteins; Region: HSPA9-Ssq1-like_NBD; cd10234
929506006173	nucleotide binding site [chemical binding]; other site
929506006174	NEF interaction site [polypeptide binding]; other site
929506006175	SBD interface [polypeptide binding]; other site
929506006176	GrpE; Region: GrpE; pfam01025
929506006177	GrpE is the adenine nucleotide exchange factor of DnaK (Hsp70)-type ATPases. The GrpE dimer binds to the ATPase domain of Hsp70 catalyzing the dissociation of ADP, which enables rebinding of ATP, one step in the Hsp70 reaction cycle in protein folding; Region: GrpE; cd00446
929506006178	dimer interface [polypeptide binding]; other site
929506006179	hsp70 (ATPase domain) interactions [polypeptide binding]; other site
929506006180	heat-inducible transcription repressor; Provisional; Region: hrcA; PRK00082
929506006181	Winged helix-turn-helix transcription repressor, HrcA DNA-binding; Region: HrcA_DNA-bdg; pfam03444
929506006182	coproporphyrinogen III oxidase; Provisional; Region: PRK05799
929506006183	HemN C-terminal domain; Region: HemN_C; pfam06969
929506006184	GTP-binding protein LepA; Provisional; Region: PRK05433
929506006185	LepA also known as Elongation Factor 4 (EF4); Region: LepA; cd01890
929506006186	G1 box; other site
929506006187	putative GEF interaction site [polypeptide binding]; other site
929506006188	GTP/Mg2+ binding site [chemical binding]; other site
929506006189	Switch I region; other site
929506006190	G2 box; other site
929506006191	G3 box; other site
929506006192	Switch II region; other site
929506006193	G4 box; other site
929506006194	G5 box; other site
929506006195	lepA_II: This subfamily represents the domain II of LepA, a GTP-binding protein localized in the cytoplasmic membrane. The N-terminal domain of LepA shares regions of homology to translation factors. In terms of interaction with the ribosome, EF-G, EF-Tu...; Region: lepA_II; cd03699
929506006196	lepA_C: This family represents the C-terminal region of LepA, a GTP-binding protein localized in the cytoplasmic membrane.   LepA is ubiquitous in Bacteria and Eukaryota (e.g. Saccharomyces cerevisiae GUF1p), but is missing from Archaea. LepA exhibits...; Region: lepA_C; cd03709
929506006197	GTP-binding protein LepA C-terminus; Region: LepA_C; pfam06421
929506006198	Stage II sporulation protein P (SpoIIP); Region: SpoIIP; pfam07454
929506006199	stage II sporulation protein P; Region: spore_II_P; TIGR02867
929506006200	germination protease; Provisional; Region: PRK12362
929506006201	30S ribosomal protein S20; Reviewed; Region: rpsT; PRK00239
929506006202	DNA polymerase III subunit delta; Reviewed; Region: holA; PRK05574
929506006203	DNA polymerase III, delta subunit; Region: DNA_pol3_delta; pfam06144
929506006204	Competence protein; Region: Competence; pfam03772
929506006205	Cation transporter/ATPase, N-terminus; Region: Cation_ATPase_N; smart00831
929506006206	Cation transport ATPase [Inorganic ion transport and metabolism]; Region: MgtA; COG0474
929506006207	E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122
929506006208	Putative hydrolase of sodium-potassium ATPase alpha subunit; Region: Hydrolase_like2; pfam13246
929506006209	comEA protein; Region: comE; TIGR01259
929506006210	Helix-hairpin-helix motif; Region: HHH; pfam00633
929506006211	Beta-lactamase enzyme family; Region: Beta-lactamase2; cl17872
929506006212	D-alanyl-D-alanine carboxypeptidase; Region: Peptidase_S11; pfam00768
929506006213	Penicillin-binding protein 5, C-terminal domain; Region: PBP5_C; smart00936
929506006214	Pseudouridylate synthases, 23S RNA-specific [Translation, ribosomal structure and biogenesis]; Region: RluA; COG0564
929506006215	S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site;  Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cl09940
929506006216	RNA binding surface [nucleotide binding]; other site
929506006217	Pseudouridine synthase, RsuA/RluD family; Region: PseudoU_synth_RluCD_like; cd02869
929506006218	active site
929506006219	Transcriptional regulator [Transcription]; Region: LytR; COG1316
929506006220	LytR cell envelope-related transcriptional attenuator; Region: LytR_C; pfam13399
929506006221	Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077
929506006222	Zn2+ binding site [ion binding]; other site
929506006223	Mg2+ binding site [ion binding]; other site
929506006224	nicotinic acid mononucleotide adenylyltransferase; Provisional; Region: nadD; PRK00071
929506006225	Nicotinamide/nicotinate mononucleotide adenylyltransferase; Region: NMNAT; cd02165
929506006226	active site
929506006227	(T/H)XGH motif; other site
929506006228	Predicted RNA-binding protein containing KH domain, possibly ribosomal protein [Translation, ribosomal structure and biogenesis]; Region: COG1534
929506006229	GTPase CgtA; Reviewed; Region: obgE; PRK12297
929506006230	GTP1/OBG; Region: GTP1_OBG; pfam01018
929506006231	Obg GTPase; Region: Obg; cd01898
929506006232	G1 box; other site
929506006233	GTP/Mg2+ binding site [chemical binding]; other site
929506006234	Switch I region; other site
929506006235	G2 box; other site
929506006236	G3 box; other site
929506006237	Switch II region; other site
929506006238	G4 box; other site
929506006239	G5 box; other site
929506006240	Domain of unknown function (DUF1967); Region: DUF1967; pfam09269
929506006241	Signal transduction histidine kinase regulating citrate/malate metabolism [Signal transduction mechanisms]; Region: CitA; COG3290
929506006242	50S ribosomal protein L27; Validated; Region: rpmA; PRK05435
929506006243	Protein of unknown function (DUF464); Region: DUF464; pfam04327
929506006244	50S ribosomal protein L21; Validated; Region: rplU; PRK05573
929506006245	S1_RNase_E: RNase E and RNase G, S1-like RNA-binding domain. RNase E is an essential endoribonuclease in the processing and degradation of RNA. In addition to its role in mRNA degradation, RNase E has also been implicated in the processing of rRNA, and...; Region: S1_RNase_E; cd04453
929506006246	homodimer interface [polypeptide binding]; other site
929506006247	oligonucleotide binding site [chemical binding]; other site
929506006248	Ribonuclease E/G family; Region: RNase_E_G; pfam10150
929506006249	DEDDh 3'-5' exonuclease domain of Caenorhabditis elegans ERI-1, human 3' exonuclease, and similar proteins; Region: ERI-1_3'hExo_like; cd06133
929506006250	active site
929506006251	catalytic site [active]
929506006252	substrate binding site [chemical binding]; other site
929506006253	radical SAM-linked protein; Region: sam_1_link_chp; TIGR03936
929506006254	Uncharacterized protein conserved in bacteria (DUF2344); Region: DUF2344; pfam10105
929506006255	radical SAM family uncharacterized protein; Region: rSAM_fuse_unch; TIGR03960
929506006256	Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335
929506006257	FeS/SAM binding site; other site
929506006258	SpoIVFB Site-2 protease (S2P), a zinc metalloprotease (MEROPS family M50B), regulates intramembrane proteolysis (RIP), and is involved in the pro-sigmaK pathway of bacterial spore formation. SpoIVFB (sporulation protein, stage IV cell wall formation, F...; Region: S2P-M50_SpoIVFB; cd06161
929506006259	Peptidase family M50; Region: Peptidase_M50; pfam02163
929506006260	active site
929506006261	putative substrate binding region [chemical binding]; other site
929506006262	Peptidase family M23; Region: Peptidase_M23; pfam01551
929506006263	thiamine biosynthesis protein ThiC; Provisional; Region: PRK13352
929506006264	thiamine biosynthesis protein ThiC; Region: thiC; TIGR00190
929506006265	Transposase domain (DUF772); Region: DUF772; pfam05598
929506006266	Transposase DDE domain; Region: DDE_Tnp_1_6; pfam13751
929506006267	Mismatch repair ATPase (MutS family) [DNA replication, recombination, and repair]; Region: MutS; COG0249
929506006268	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
929506006269	Walker A/P-loop; other site
929506006270	ATP binding site [chemical binding]; other site
929506006271	Q-loop/lid; other site
929506006272	ABC transporter signature motif; other site
929506006273	Walker B; other site
929506006274	D-loop; other site
929506006275	H-loop/switch region; other site
929506006276	cysteine desulfurase activator complex subunit SufB; Provisional; Region: PRK11814; cl03223
929506006277	Uncharacterized protein family (UPF0051); Region: UPF0051; pfam01458
929506006278	Cysteine desulfurase activator ATPase [Posttranslational modification, protein turnover, chaperones]; Region: sufC; COG0396
929506006279	First domain of the ATP-binding cassette component of cobalt transport system; Region: ABC_cobalt_CbiO_domain1; cd03225
929506006280	Walker A/P-loop; other site
929506006281	ATP binding site [chemical binding]; other site
929506006282	Q-loop/lid; other site
929506006283	ABC transporter signature motif; other site
929506006284	Walker B; other site
929506006285	D-loop; other site
929506006286	H-loop/switch region; other site
929506006287	Positive regulator of sigma(E), RseC/MucC; Region: RseC_MucC; pfam04246
929506006288	glutamate dehydrogenase; Provisional; Region: PRK09414
929506006289	Glu/Leu/Phe/Val dehydrogenase, dimerisation domain; Region: ELFV_dehydrog_N; pfam02812
929506006290	NAD(P) binding domain of glutamate dehydrogenase, subgroup 2; Region: NAD_bind_2_Glu_DH; cd05313
929506006291	NAD(P) binding site [chemical binding]; other site
929506006292	Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer); Region: MA; smart00283
929506006293	Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386
929506006294	dimer interface [polypeptide binding]; other site
929506006295	putative CheW interface [polypeptide binding]; other site
929506006296	3-oxoacyl-[acyl-carrier-protein]; Region: FabH; COG0332
929506006297	Ketoacyl-acyl carrier protein synthase III (KASIII) initiates the elongation in type II fatty acid synthase systems. It is found in bacteria and plants. Elongation of fatty acids in the type II systems occurs by Claisen condensation of malonyl-acyl...; Region: KAS_III; cd00830
929506006298	dimer interface [polypeptide binding]; other site
929506006299	active site
929506006300	CoA binding pocket [chemical binding]; other site
929506006301	Nucleoside-diphosphate-sugar pyrophosphorylase involved in lipopolysaccharide biosynthesis/translation initiation factor 2B, gamma/epsilon subunits (eIF-2Bgamma/eIF-2Bepsilon) [Cell envelope biogenesis, outer membrane / Translation, ribosomal structure...; Region: GCD1; COG1208
929506006302	NTP_transferases catalyze the transfer of nucleotides onto phosphosugars; Region: NTP_transferase; cd04181
929506006303	active site
929506006304	Substrate binding site; other site
929506006305	Mg++ binding site; other site
929506006306	Left-handed parallel beta-Helix (LbetaH or LbH) domain: The alignment contains 5 turns, each containing three imperfect tandem repeats of a hexapeptide repeat motif (X-[STAV]-X-[LIV]-[GAED]-X). Proteins containing hexapeptide repeats are often enzymes...; Region: LbetaH; cl00160
929506006307	putative trimer interface [polypeptide binding]; other site
929506006308	putative CoA binding site [chemical binding]; other site
929506006309	phosphoglucosamine mutase; Region: Arch_GlmM; TIGR03990
929506006310	The alpha-D-phosphohexomutase superfamily includes several related enzymes that catalyze a reversible intramolecular phosphoryl transfer on their sugar substrates. Members of this family include the phosphoglucomutases (PGM1 and PGM2), phosphoglucosamine...; Region: phosphohexomutase; cl03757
929506006311	active site
929506006312	substrate binding site [chemical binding]; other site
929506006313	metal binding site [ion binding]; metal-binding site
929506006314	Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438
929506006315	This family is most closely related to the GT1 family of glycosyltransferases and named after YqgM in Bacillus licheniformis about which little is known. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to...; Region: GT1_YqgM_like; cd03801
929506006316	Membrane protease subunits, stomatin/prohibitin homologs [Posttranslational modification, protein turnover, chaperones]; Region: HflC; COG0330
929506006317	Band_7_stomatin_like: A subgroup of the band 7 domain of flotillin (reggie) like proteins similar to stomatin and podicin (two lipid raft-associated integral membrane proteins). Individual proteins of this band 7 domain family may cluster to form...; Region: Band_7_stomatin_like; cd03403
929506006318	Membrane protein implicated in regulation of membrane protease activity [Posttranslational modification, protein turnover, chaperones / Intracellular trafficking and secretion]; Region: COG1585
929506006319	NAD synthetase; Reviewed; Region: nadE; PRK02628
929506006320	Glutamine aminotransferase (GAT, glutaminase) domain of glutamine-dependent NAD synthetases (class 7 and 8 nitrilases); Region: GAT_Gln-NAD-synth; cd07570
929506006321	multimer interface [polypeptide binding]; other site
929506006322	active site
929506006323	catalytic triad [active]
929506006324	protein interface 1 [polypeptide binding]; other site
929506006325	NAD+ synthase is a homodimer, which catalyzes the final step in de novo nicotinamide adenine dinucleotide (NAD+) biosynthesis, an amide transfer from either ammonia or glutamine to nicotinic acid adenine dinucleotide (NaAD). The conversion of NaAD to NAD...; Region: NAD_synthase; cd00553
929506006326	homodimer interface [polypeptide binding]; other site
929506006327	NAD binding pocket [chemical binding]; other site
929506006328	ATP binding pocket [chemical binding]; other site
929506006329	Mg binding site [ion binding]; other site
929506006330	active-site loop [active]
929506006331	Protein of unknown function (DUF327); Region: DUF327; pfam03885
929506006332	Cation transporter/ATPase, N-terminus; Region: Cation_ATPase_N; pfam00690
929506006333	Cation transport ATPase [Inorganic ion transport and metabolism]; Region: MgtA; COG0474
929506006334	E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122
929506006335	Putative hydrolase of sodium-potassium ATPase alpha subunit; Region: Hydrolase_like2; pfam13246
929506006336	Soluble P-type ATPase [General function prediction only]; Region: COG4087
929506006337	Cation transporting ATPase, C-terminus; Region: Cation_ATPase_C; pfam00689
929506006338	Domain of unknown function (DUF4184); Region: DUF4184; pfam13803
929506006339	c-di-GMP phosphodiesterase class II (HD-GYP domain) [Signal transduction mechanisms]; Region: COG2206
929506006340	Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077
929506006341	Zn2+ binding site [ion binding]; other site
929506006342	Mg2+ binding site [ion binding]; other site
929506006343	Polymerase and Histidinol Phosphatase domain; Region: PHP; cl17102
929506006344	active site
929506006345	histidinol-phosphatase; Provisional; Region: PRK05588
929506006346	Polymerase and Histidinol Phosphatase domain; Region: PHP; cl17102
929506006347	active site
929506006348	AsnC-type helix-turn-helix domain; Region: HTH_AsnC-type; pfam13404
929506006349	AsnC family; Region: AsnC_trans_reg; pfam01037
929506006350	Uncharacterized conserved protein [Function unknown]; Region: COG2155
929506006351	Na+/H+ antiporter [Energy production and conversion]; Region: NhaC; COG1757
929506006352	argininosuccinate lyase; Provisional; Region: PRK00855
929506006353	Argininosuccinate lyase (argininosuccinase, ASAL); Region: Argininosuccinate_lyase; cd01359
929506006354	active sites [active]
929506006355	tetramer interface [polypeptide binding]; other site
929506006356	argininosuccinate synthase; Provisional; Region: PRK13820
929506006357	Argininosuccinate synthase. The Argininosuccinate synthase is a urea cycle enzyme that catalyzes the penultimate step in arginine biosynthesis: the ATP-dependent ligation of citrulline to aspartate to form argininosuccinate, AMP and pyrophosphate .  In...; Region: Argininosuccinate_Synthase; cd01999
929506006358	ANP binding site [chemical binding]; other site
929506006359	Substrate Binding Site II [chemical binding]; other site
929506006360	Substrate Binding Site I [chemical binding]; other site
929506006361	ABC-type polar amino acid transport system, ATPase component [Amino acid transport and metabolism]; Region: GlnQ; COG1126
929506006362	ATP-binding cassette domain of the histidine and glutamine transporters; Region: ABC_HisP_GlnQ; cd03262
929506006363	Walker A/P-loop; other site
929506006364	ATP binding site [chemical binding]; other site
929506006365	Q-loop/lid; other site
929506006366	ABC transporter signature motif; other site
929506006367	Walker B; other site
929506006368	D-loop; other site
929506006369	H-loop/switch region; other site
929506006370	ABC-type arginine transport system, permease component [Amino acid transport and metabolism]; Region: ArtQ; COG4215
929506006371	amine acid ABC transporter, permease protein, 3-TM region, His/Glu/Gln/Arg/opine family; Region: HEQRo_perm_3TM; TIGR01726
929506006372	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
929506006373	putative PBP binding loops; other site
929506006374	dimer interface [polypeptide binding]; other site
929506006375	ABC-ATPase subunit interface; other site
929506006376	Bacterial extracellular solute-binding proteins, family 3; Region: SBP_bac_3; pfam00497
929506006377	Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of  substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134
929506006378	substrate binding pocket [chemical binding]; other site
929506006379	membrane-bound complex binding site; other site
929506006380	hinge residues; other site
929506006381	Isocitrate/isopropylmalate dehydrogenase [Amino acid transport and metabolism]; Region: LeuB; COG0473
929506006382	isocitrate dehydrogenase; Validated; Region: PRK06451
929506006383	aconitate hydratase; Validated; Region: PRK07229
929506006384	Aconitase catalyzes the reversible isomerization of citrate and isocitrate as part of the TCA cycle; Region: AcnA_Bact; cd01585
929506006385	substrate binding site [chemical binding]; other site
929506006386	ligand binding site [chemical binding]; other site
929506006387	Aconitase swivel domain. Aconitase (aconitate hydratase) catalyzes the reversible isomerization of citrate and isocitrate as part of the TCA cycle. This is the aconitase swivel domain, which undergoes swivelling conformational change in the enzyme...; Region: Aconitase_swivel; cl00215
929506006388	substrate binding site [chemical binding]; other site
929506006389	1-acyl-sn-glycerol-3-phosphate acyltransferase [Lipid metabolism]; Region: PlsC; COG0204
929506006390	Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: AGPAT-like; Region: LPLAT_AGPAT-like; cd07989
929506006391	putative acyl-acceptor binding pocket; other site
929506006392	Predicted hydrolase (metallo-beta-lactamase superfamily) [General function prediction only]; Region: ComEC; COG2333
929506006393	Metallo-beta-lactamase superfamily; Region: Lactamase_B; smart00849
929506006394	prolipoprotein diacylglyceryl transferase; Reviewed; Region: PRK12437
929506006395	undecaprenyl pyrophosphate phosphatase; Reviewed; Region: PRK12554
929506006396	Transglutaminase-like superfamily; Region: Transglut_core; cl17362
929506006397	Predicted Co/Zn/Cd cation transporters [Inorganic ion transport and metabolism]; Region: MMT1; COG0053
929506006398	cation diffusion facilitator family transporter; Region: CDF; TIGR01297
929506006399	Transcriptional regulators [Transcription]; Region: PurR; COG1609
929506006400	Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392
929506006401	DNA binding site [nucleotide binding]
929506006402	domain linker motif; other site
929506006403	Ligand binding domain of the LacI tanscriptional regulator family belonging to the type I periplasmic-binding fold protein superfamily; Region: PBP1_LacI_sugar_binding_like; cd06267
929506006404	dimerization interface [polypeptide binding]; other site
929506006405	ligand binding site [chemical binding]; other site
929506006406	D-ribose transporter subunit RbsB; Provisional; Region: PRK10653
929506006407	Periplasmic sugar-binding domain of the thermophilic Thermoanaerobacter tengcongensis ribose binding protein (ttRBP) and its mesophilic homologs; Region: PBP1_ribose_binding; cd06323
929506006408	ligand binding site [chemical binding]; other site
929506006409	dimerization interface [polypeptide binding]; other site
929506006410	Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653
929506006411	Transmembrane subunit (TM) of Escherichia coli AraH and related proteins. E. coli AraH is the TM of a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of the monosaccharide arabinose. This group...; Region: TM_PBP1_transp_AraH_like; cd06579
929506006412	TM-ABC transporter signature motif; other site
929506006413	ABC-type sugar transport system, ATPase component [Carbohydrate transport and metabolism]; Region: MglA; COG1129
929506006414	First domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_I; cd03216
929506006415	Walker A/P-loop; other site
929506006416	ATP binding site [chemical binding]; other site
929506006417	Q-loop/lid; other site
929506006418	ABC transporter signature motif; other site
929506006419	Walker B; other site
929506006420	D-loop; other site
929506006421	H-loop/switch region; other site
929506006422	Second domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_II; cd03215
929506006423	D-ribose pyranase; Provisional; Region: PRK11797
929506006424	Sugar kinases, ribokinase family [Carbohydrate transport and metabolism]; Region: RbsK; COG0524
929506006425	Ribokinase catalyses the phosphorylation of ribose to ribose-5-phosphate using ATP. This reaction is the first step in the ribose metabolism. It traps ribose within the cell after uptake and also prepares the sugar for use in the synthesis of nucleotides...; Region: ribokinase; cd01174
929506006426	substrate binding site [chemical binding]; other site
929506006427	dimer interface [polypeptide binding]; other site
929506006428	ATP binding site [chemical binding]; other site
929506006429	Spo0E like sporulation regulatory protein; Region: SpoOE-like; pfam09388
929506006430	Imidazolonepropionase and related amidohydrolases [Secondary metabolites biosynthesis, transport, and catabolism]; Region: HutI; COG1228
929506006431	Metallo-dependent hydrolases, subgroup C is part of the superfamily of metallo-dependent hydrolases, a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the...; Region: Met_dep_hydrolase_C; cd01309
929506006432	active site
929506006433	Putative heavy-metal-binding; Region: YbjQ_1; cl00426
929506006434	Elongator protein 3, MiaB family, Radical SAM; Region: Elp3; smart00729
929506006435	Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335
929506006436	FeS/SAM binding site; other site
929506006437	Transglutaminase-like superfamily; Region: Transglut_core; pfam01841
929506006438	Uncharacterized proteins with similarity to Ribonucleotide reductase and Pyruvate formate lyase; Region: RNR_PFL_like_DUF711; cd08025
929506006439	Four helix bundle sensory module for signal transduction; Region: 4HB_MCP_1; pfam12729
929506006440	HAMP (Histidine kinases, Adenylyl cyclases, Methyl binding proteins, Phosphatases) domain; Region: HAMP; smart00304
929506006441	dimerization interface [polypeptide binding]; other site
929506006442	Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer); Region: MA; smart00283
929506006443	Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386
929506006444	dimer interface [polypeptide binding]; other site
929506006445	putative CheW interface [polypeptide binding]; other site
929506006446	Undecaprenyl pyrophosphate synthase [Lipid metabolism]; Region: UppS; COG0020
929506006447	Cis (Z)-Isoprenyl Diphosphate Synthases (cis-IPPS); homodimers which catalyze the successive 1'-4 condensation of the isopentenyl diphosphate (IPP) molecule to trans,trans-farnesyl diphosphate (FPP) or to cis,trans-FPP to form long-chain polyprenyl...; Region: CIS_IPPS; cl00230
929506006448	catalytic residue [active]
929506006449	putative FPP diphosphate  binding site; other site
929506006450	putative FPP binding hydrophobic cleft; other site
929506006451	dimer interface [polypeptide binding]; other site
929506006452	putative IPP diphosphate binding site; other site
929506006453	Signal peptidase (SPase) II; Region: Peptidase_A8; cl00458
929506006454	Protein Kinases, catalytic domain; Region: PKc_like; cl09925
929506006455	active site
929506006456	ATP binding site [chemical binding]; other site
929506006457	substrate binding site [chemical binding]; other site
929506006458	Aminoglycoside 3'-phosphotransferase (APH) and Choline Kinase (ChoK) family. The APH/ChoK family is part of a larger superfamily that includes the catalytic domains of other kinases, such as the typical serine/threonine/tyrosine protein kinases (PKs)...; Region: APH_ChoK_like; cl17270
929506006459	active site
929506006460	substrate binding site [chemical binding]; other site
929506006461	ATP binding site [chemical binding]; other site
929506006462	Predicted RNA-bindining protein (contains S1 and HTH domains) [General function prediction only]; Region: COG2996
929506006463	S1 domain; Region: S1_2; pfam13509
929506006464	S1 domain; Region: S1_2; pfam13509
929506006465	Ribosomal protein S1-like RNA-binding domain; Region: S1; smart00316
929506006466	RNA binding site [nucleotide binding]; other site
929506006467	haloacid dehalogenase-like hydrolase; Region: Hydrolase; pfam00702
929506006468	Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427
929506006469	motif II; other site
929506006470	Transposase, Mutator family; Region: Transposase_mut; pfam00872
929506006471	MULE transposase domain; Region: MULE; pfam10551
929506006472	Transcriptional regulator [Transcription]; Region: LysR; COG0583
929506006473	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
929506006474	C-terminal substrate binding domain of LysR-type transcriptional regulator CysL, which activates the transcription of the cysJI operon encoding sulfite reductase, contains the type 2 periplasmic binding fold; Region: PBP2_CysL_like; cd08420
929506006475	putative dimerization interface [polypeptide binding]; other site
929506006476	Branched-chain amino acid aminotransferase/4-amino-4-deoxychorismate lyase [Amino acid transport and metabolism / Coenzyme metabolism]; Region: IlvE; COG0115
929506006477	BCAT_beta_family: Branched-chain aminotransferase catalyses the transamination of the branched-chain amino acids  leusine, isoleucine and valine to their respective alpha-keto acids, alpha-ketoisocaproate, alpha-keto-beta-methylvalerate and...; Region: BCAT_beta_family; cd01557
929506006478	homodimer interface [polypeptide binding]; other site
929506006479	substrate-cofactor binding pocket; other site
929506006480	catalytic residue [active]
929506006481	DL-methionine transporter substrate-binding subunit; Provisional; Region: metQ; PRK11063
929506006482	NLPA lipoprotein; Region: Lipoprotein_9; pfam03180
929506006483	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
929506006484	dimer interface [polypeptide binding]; other site
929506006485	conserved gate region; other site
929506006486	ABC-ATPase subunit interface; other site
929506006487	ABC-type metal ion transport system, ATPase component [Inorganic ion transport and metabolism]; Region: AbcC; COG1135
929506006488	ATP-binding cassette domain of methionine transporter; Region: ABC_MetN_methionine_transporter; cd03258
929506006489	Walker A/P-loop; other site
929506006490	ATP binding site [chemical binding]; other site
929506006491	Q-loop/lid; other site
929506006492	ABC transporter signature motif; other site
929506006493	Walker B; other site
929506006494	D-loop; other site
929506006495	H-loop/switch region; other site
929506006496	This domain is found at the C-terminus of ABC transporter proteins involved in D-methionine transport as well as a number of ferredoxin-like proteins; Region: NIL; smart00930
929506006497	aspartate kinase; Reviewed; Region: PRK09034
929506006498	Amino Acid Kinases (AAK) superfamily, catalytic domain; present in such enzymes like N-acetylglutamate kinase (NAGK), carbamate kinase (CK), aspartokinase (AK), glutamate-5-kinase (G5K) and UMP kinase (UMPK). The AAK superfamily includes kinases that...; Region: AAK; cl00452
929506006499	nucleotide binding site [chemical binding]; other site
929506006500	substrate binding site [chemical binding]; other site
929506006501	ACT domains located C-terminal to the catalytic domain of the lysine plus threonine-sensitive aspartokinase isoenzyme AKIII; Region: ACT_AKiii-YclM-BS_1; cd04911
929506006502	allosteric regulatory residue; other site
929506006503	ACT domains located C-terminal to the catalytic domain of the lysine plus threonine-sensitive aspartokinase isoenzyme AKIII; Region: ACT_AKiii-YclM-BS_2; cd04916
929506006504	methionine aminopeptidase; Provisional; Region: PRK12318
929506006505	SEC-C motif; Region: SEC-C; pfam02810
929506006506	Methionine Aminopeptidase 1. E.C. 3.4.11.18. Also known as methionyl aminopeptidase and Peptidase M. Catalyzes release of N-terminal amino acids, preferentially methionine, from peptides and arylamides; Region: MetAP1; cd01086
929506006507	active site
929506006508	germination protein, Ger(x)C family; Region: spore_ger_x_C; TIGR02887
929506006509	Spore germination B3/ GerAC like, C-terminal; Region: Spore_GerAC; pfam05504
929506006510	Spore germination protein; Region: Spore_permease; cl17796
929506006511	Bacillus/Clostridium GerA spore germination protein; Region: GerA; pfam03323
929506006512	Xanthine/uracil permeases [Nucleotide transport and metabolism]; Region: UraA; COG2233
929506006513	Superoxide dismutase [Inorganic ion transport and metabolism]; Region: SodA; COG0605
929506006514	Iron/manganese superoxide dismutases, alpha-hairpin domain; Region: Sod_Fe_N; pfam00081
929506006515	Iron/manganese superoxide dismutases, C-terminal domain; Region: Sod_Fe_C; pfam02777
929506006516	Chloride channel protein EriC [Inorganic ion transport and metabolism]; Region: EriC; COG0038
929506006517	ClC chloride channel EriC.  This domain is found in the EriC chloride transporters that mediate the extreme acid resistance response in eubacteria and archaea. This response allows bacteria to survive in the acidic environments by decarboxylation-linked...; Region: EriC; cd01031
929506006518	Cl- selectivity filter; other site
929506006519	Cl- binding residues [ion binding]; other site
929506006520	pore gating glutamate residue; other site
929506006521	dimer interface [polypeptide binding]; other site
929506006522	H+/Cl- coupling transport residue; other site
929506006523	TrkA-C domain; Region: TrkA_C; pfam02080
929506006524	putative transporter; Provisional; Region: PRK10484
929506006525	uncharacterized SLC5 subfamily, Escherichia coli YidK-like; solute binding domain; Region: SLC5sbd_YidK; cd10328
929506006526	Na binding site [ion binding]; other site
929506006527	Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673
929506006528	Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408
929506006529	Oxidoreductase family, C-terminal alpha/beta domain; Region: GFO_IDH_MocA_C; pfam02894
929506006530	Sugar phosphate isomerases/epimerases [Carbohydrate transport and metabolism]; Region: IolE; COG1082
929506006531	AP endonuclease family 2; These endonucleases play a role in DNA repair. Cleave phosphodiester bonds at apurinic or apyrimidinic sites; the alignment also contains hexulose-6-phosphate isomerases, enzymes that catalyze the epimerization of...; Region: AP2Ec; cl12060
929506006532	Metal-binding active site; metal-binding site
929506006533	Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673
929506006534	Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408
929506006535	Oxidoreductase family, C-terminal alpha/beta domain; Region: GFO_IDH_MocA_C; pfam02894
929506006536	Acetolactate synthase [Amino acid transport and metabolism]; Region: COG3962
929506006537	Pyrimidine (PYR) binding domain of POX and related proteins; Region: TPP_PYR_POX_like; cd07035
929506006538	PYR/PP interface [polypeptide binding]; other site
929506006539	dimer interface [polypeptide binding]; other site
929506006540	TPP binding site [chemical binding]; other site
929506006541	Thiamine pyrophosphate enzyme, central domain; Region: TPP_enzyme_M; pfam00205
929506006542	Thiamine pyrophosphate (TPP) family, IolD subfamily, TPP-binding module; composed of proteins similar to Rhizobium leguminosarum bv. viciae IolD. IolD plays an important role in myo-inositol catabolism; Region: TPP_IolD; cd02003
929506006543	TPP-binding site; other site
929506006544	KduI/IolB family; Region: KduI; pfam04962
929506006545	Sugar kinases, ribokinase family [Carbohydrate transport and metabolism]; Region: RbsK; COG0524
929506006546	2-keto-3-deoxygluconate kinase (KdgK) phosphorylates 2-keto-3-deoxygluconate (KDG) to form 2-keto-3-deoxy-6-phosphogluconate (KDGP). KDG is the common intermediate product, that allows organisms to channel D-glucuronate and/or D-galacturinate into the...; Region: KdgK; cd01166
929506006547	substrate binding site [chemical binding]; other site
929506006548	ATP binding site [chemical binding]; other site
929506006549	Tagatose-1,6-bisphosphate (TBP) aldolase and related Type B Class II aldolases. TBP aldolase is a tetrameric class II aldolase that catalyzes the reversible condensation of dihydroxyacetone phosphate with glyceraldehyde 3-phsophate to produce tagatose 1; Region: TBP_aldolase_IIB; cd00947
929506006550	intersubunit interface [polypeptide binding]; other site
929506006551	active site
929506006552	zinc binding site [ion binding]; other site
929506006553	Na+ binding site [ion binding]; other site
929506006554	Alcohol dehydrogenase, class IV [Energy production and conversion]; Region: EutG; COG1454
929506006555	Iron-containing alcohol dehydrogenases-like; Region: Fe-ADH6; cd08194
929506006556	putative active site [active]
929506006557	metal binding site [ion binding]; metal-binding site
929506006558	Transcriptional regulators of sugar metabolism [Transcription / Carbohydrate transport and metabolism]; Region: GlpR; COG1349
929506006559	DeoR-like helix-turn-helix domain; Region: HTH_DeoR; pfam08220
929506006560	DeoR C terminal sensor domain; Region: DeoRC; pfam00455
929506006561	B12 binding domain (B12-BD). Most of the members bind different cobalamid derivates, like B12 (adenosylcobamide) or methylcobalamin or methyl-Co(III) 5-hydroxybenzimidazolylcobamide. This domain is found in several enzymes, such as glutamate mutase; Region: B12-binding_like; cl00293
929506006562	YibE/F-like protein; Region: YibE_F; pfam07907
929506006563	5'-nucleotidase/2',3'-cyclic phosphodiesterase and related esterases [Nucleotide transport and metabolism]; Region: UshA; COG0737
929506006564	Escherichia coli UshA-like family, N-terminal metallophosphatase domain; Region: MPP_UshA_N_like; cd00845
929506006565	active site
929506006566	metal binding site [ion binding]; metal-binding site
929506006567	5'-nucleotidase, C-terminal domain; Region: 5_nucleotid_C; pfam02872
929506006568	Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118
929506006569	Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118
929506006570	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3677
929506006571	InsA N-terminal domain; Region: Zn_Tnp_IS1; pfam03811
929506006572	DDE domain; Region: DDE_Tnp_IS240; pfam13610
929506006573	Integrase core domain; Region: rve; pfam00665
929506006574	Integrase core domain; Region: rve_3; pfam13683
929506006575	Beta-galactosidase, beta subunit [Carbohydrate transport and metabolism]; Region: EbgC; COG2731
929506006576	4Fe-4S dicluster domain; Region: Fer4_7; pfam12838
929506006577	4Fe-4S binding domain; Region: Fer4_6; pfam12837
929506006578	Iron only hydrogenase large subunit, C-terminal domain; Region: Fe_hyd_lg_C; pfam02906
929506006579	Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer); Region: MA; smart00283
929506006580	Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386
929506006581	dimer interface [polypeptide binding]; other site
929506006582	putative CheW interface [polypeptide binding]; other site
929506006583	GGGtGRT protein; Region: GGGtGRT; pfam14057
929506006584	NifU homolog involved in Fe-S cluster formation [Energy production and conversion]; Region: IscU; COG0822
929506006585	Iron-sulfur cluster scaffold-like proteins; Region: IscU_like; cl00528
929506006586	Short-chain dehydrogenases of various substrate specificities [General function prediction only]; Region: DltE; COG0300
929506006587	classical (c) SDRs; Region: SDR_c; cd05233
929506006588	NAD(P) binding site [chemical binding]; other site
929506006589	active site
929506006590	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
929506006591	ATPases associated with a variety of cellular activities; Region: AAA; smart00382
929506006592	Walker A motif; other site
929506006593	ATP binding site [chemical binding]; other site
929506006594	Walker B motif; other site
929506006595	arginine finger; other site
929506006596	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
929506006597	Zeta toxin; Region: Zeta_toxin; pfam06414
929506006598	Walker A motif; other site
929506006599	ATP binding site [chemical binding]; other site
929506006600	Walker B motif; other site
929506006601	arginine finger; other site
929506006602	C-terminal, D2-small domain, of ClpB protein; Region: ClpB_D2-small; pfam10431
929506006603	Selenocysteine lyase/Cysteine desulfurase [Posttranslational modification, protein turnover, chaperones]; Region: csdA; COG0520
929506006604	Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321
929506006605	pyridoxal 5'-phosphate binding pocket [chemical binding]; other site
929506006606	catalytic residue [active]
929506006607	Sporulation protein YtrH; Region: Spore_YtrH; pfam14034
929506006608	Protein Kinases, catalytic domain; Region: PKc_like; cl09925
929506006609	substrate binding site [chemical binding]; other site
929506006610	AAA ATPase domain; Region: AAA_16; pfam13191
929506006611	Predicted ATPase [General function prediction only]; Region: COG3899
929506006612	Domain present in phytochromes and cGMP-specific phosphodiesterases; Region: GAF; smart00065
929506006613	FOG: GAF domain [Signal transduction mechanisms]; Region: FhlA; COG2203
929506006614	Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642
929506006615	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
929506006616	dimer interface [polypeptide binding]; other site
929506006617	phosphorylation site [posttranslational modification]
929506006618	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
929506006619	ATP binding site [chemical binding]; other site
929506006620	Mg2+ binding site [ion binding]; other site
929506006621	G-X-G motif; other site
929506006622	Predicted esterase of the alpha-beta hydrolase superfamily [General function prediction only]; Region: COG4667
929506006623	Hypothetical patatin similar to yjju protein of Escherichia coli; Region: Pat_hypo_Ecoli_yjju_like; cd07208
929506006624	active site
929506006625	nucleophile elbow; other site
929506006626	Coat F domain; Region: Coat_F; pfam07875
929506006627	Subfamily of the multidrug and toxic compound extrusion (MATE)-like proteins similar to Streptococcus aureus MepA; Region: MATE_MepA_like; cd13143
929506006628	Na+-driven multidrug efflux pump [Defense mechanisms]; Region: NorM; COG0534
929506006629	Small-conductance mechanosensitive channel [Cell envelope biogenesis, outer membrane]; Region: MscS; COG0668
929506006630	Mechanosensitive ion channel; Region: MS_channel; pfam00924
929506006631	putative UV damage endonuclease; Provisional; Region: uvsE; PRK02308
929506006632	Exonuclease-Endonuclease-Phosphatase (EEP) domain superfamily; Region: EEP; cl00490
929506006633	EamA-like transporter family; Region: EamA; pfam00892
929506006634	Permeases of the drug/metabolite transporter (DMT) superfamily [Carbohydrate transport and metabolism / Amino acid transport and metabolism / General function prediction only]; Region: RhaT; COG0697
929506006635	EamA-like transporter family; Region: EamA; pfam00892
929506006636	citrate synthase; Provisional; Region: PRK14032
929506006637	Citrate synthase; Region: Citrate_synt; pfam00285
929506006638	oxalacetate binding site [chemical binding]; other site
929506006639	citrylCoA binding site [chemical binding]; other site
929506006640	coenzyme A binding site [chemical binding]; other site
929506006641	catalytic triad [active]
929506006642	Sodium/hydrogen exchanger family; Region: Na_H_Exchanger; pfam00999
929506006643	Kef-type K+ transport systems, membrane components [Inorganic ion transport and metabolism]; Region: KefB; COG0475
929506006644	TrkA-C domain; Region: TrkA_C; pfam02080
929506006645	acetyl-CoA carboxylase biotin carboxylase subunit; Validated; Region: PRK08591
929506006646	Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289
929506006647	Carbamoyl-phosphate synthase L chain, ATP binding domain; Region: CPSase_L_D2; pfam02786
929506006648	Biotin carboxylase C-terminal domain; Region: Biotin_carb_C; smart00878
929506006649	acetyl-CoA carboxylase, biotin carboxyl carrier protein; Region: BCCP; TIGR00531
929506006650	The biotinyl-domain or biotin carboxyl carrier protein (BCCP) domain is present in all biotin-dependent enzymes, such as acetyl-CoA carboxylase, pyruvate carboxylase, propionyl-CoA carboxylase, methylcrotonyl-CoA carboxylase, geranyl-CoA carboxylase; Region: biotinyl_domain; cd06850
929506006651	carboxyltransferase (CT) interaction site; other site
929506006652	biotinylation site [posttranslational modification]; other site
929506006653	Mn2+ and Fe2+ transporters of the NRAMP family [Inorganic ion transport and metabolism]; Region: MntH; COG1914
929506006654	LamB/YcsF family of  lactam utilization protein; Region: LamB_YcsF_like; cd10787
929506006655	putative active site [active]
929506006656	Allophanate hydrolase subunit 2 [Amino acid transport and metabolism]; Region: DUR1; COG1984
929506006657	Allophanate hydrolase subunit 1; Region: AHS1; pfam02682
929506006658	Allophanate hydrolase subunit 1 [Amino acid transport and metabolism]; Region: DUR1; cl00896
929506006659	L-lactate dehydrogenase; Reviewed; Region: ldh; PRK00066
929506006660	A subgroup of L-lactate dehydrogenases; Region: LDH_2; cd05292
929506006661	NAD binding site [chemical binding]; other site
929506006662	dimer interface [polypeptide binding]; other site
929506006663	substrate binding site [chemical binding]; other site
929506006664	tetramer (dimer of dimers) interface [polypeptide binding]; other site
929506006665	Protein Kinases, catalytic domain; Region: PKc_like; cl09925
929506006666	active site
929506006667	ATP binding site [chemical binding]; other site
929506006668	substrate binding site [chemical binding]; other site
929506006669	activation loop (A-loop); other site
929506006670	Predicted ATPase [General function prediction only]; Region: COG3899
929506006671	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
929506006672	binding surface
929506006673	TPR motif; other site
929506006674	Tetratricopeptide repeat; Region: TPR_12; pfam13424
929506006675	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
929506006676	binding surface
929506006677	Tetratricopeptide repeat; Region: TPR_12; pfam13424
929506006678	TPR motif; other site
929506006679	c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal    transduction mechanisms]; Region: COG2199
929506006680	Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949
929506006681	metal binding site [ion binding]; metal-binding site
929506006682	active site
929506006683	I-site; other site
929506006684	Nucleoside diphosphate kinase Group I (NDPk_I)-like: NDP kinase domains are present in a large family of structurally and functionally conserved proteins from bacteria to humans that generally catalyze the transfer of gamma-phosphates of a nucleoside...; Region: NDPk_I; cd04413
929506006685	active site
929506006686	multimer interface [polypeptide binding]; other site
929506006687	ADP-ribose pyrophosphatase (ADPRase) catalyzes the hydrolysis of ADP-ribose and a variety of additional ADP-sugar conjugates to AMP and ribose-5-phosphate. Like other members of the Nudix hydrolase superfamily, it requires a divalent cation, such as Mg2+; Region: ADPRase_NUDT5; cd03424
929506006688	dimer interface [polypeptide binding]; other site
929506006689	ADP-ribose binding site [chemical binding]; other site
929506006690	active site
929506006691	nudix motif; other site
929506006692	metal binding site [ion binding]; metal-binding site
929506006693	Methionine synthase I (cobalamin-dependent), methyltransferase domain [Amino acid transport and metabolism]; Region: MetH; cl14105
929506006694	Homocysteine S-methyltransferase; Region: S-methyl_trans; pfam02574
929506006695	Pterin binding enzymes. This family includes dihydropteroate synthase (DHPS) and cobalamin-dependent methyltransferases such as methyltetrahydrofolate, corrinoid iron-sulfur protein methyltransferase (MeTr) and methionine synthase (MetH).  DHPS, a...; Region: Pterin_binding; cl00219
929506006696	substrate binding pocket [chemical binding]; other site
929506006697	dimer interface [polypeptide binding]; other site
929506006698	inhibitor binding site; inhibition site
929506006699	B12 binding domain (B12-BD). Most of the members bind different cobalamid derivates, like B12 (adenosylcobamide) or methylcobalamin or methyl-Co(III) 5-hydroxybenzimidazolylcobamide. This domain is found in several enzymes, such as glutamate mutase; Region: B12-binding_like; cl00293
929506006700	methyltransferase cognate corrinoid proteins, Methanosarcina family; Region: pyl_corrinoid; TIGR02370
929506006701	B12 binding site [chemical binding]; other site
929506006702	ABC-type transport system involved in multi-copper enzyme maturation, permease component [General function prediction only]; Region: NosY; COG1277
929506006703	ABC-2 family transporter protein; Region: ABC2_membrane_4; pfam12730
929506006704	ABC-type multidrug transport system, ATPase component [Defense mechanisms]; Region: CcmA; COG1131
929506006705	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
929506006706	Walker A/P-loop; other site
929506006707	ATP binding site [chemical binding]; other site
929506006708	Q-loop/lid; other site
929506006709	ABC transporter signature motif; other site
929506006710	Walker B; other site
929506006711	D-loop; other site
929506006712	H-loop/switch region; other site
929506006713	ABC-type multidrug transport system, ATPase component [Defense mechanisms]; Region: CcmA; COG1131
929506006714	ATP-binding cassette domain of the drug resistance transporter and related proteins, subfamily A; Region: ABC_DR_subfamily_A; cd03230
929506006715	Walker A/P-loop; other site
929506006716	ATP binding site [chemical binding]; other site
929506006717	Q-loop/lid; other site
929506006718	ABC transporter signature motif; other site
929506006719	Walker B; other site
929506006720	D-loop; other site
929506006721	H-loop/switch region; other site
929506006722	Predicted transcriptional regulators [Transcription]; Region: COG1725
929506006723	Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377
929506006724	DNA-binding site [nucleotide binding]; DNA binding site
929506006725	ExoU and VipD-like proteins; homologus to patatin, cPLA2, and iPLA2; Region: Pat_ExoU_VipD_like; cd07207
929506006726	Predicted esterase of the alpha-beta hydrolase superfamily [General function prediction only]; Region: RssA; COG1752
929506006727	nucleophile elbow; other site
929506006728	4-amino-5-hydroxymethyl-2-methyl-pyrimidine phosphate kinase (HMPP-kinase) catalyzes two consecutive phosphorylation steps in the thiamine phosphate biosynthesis pathway, leading to the synthesis of vitamin B1. The first step is the phosphorylation of...; Region: HMPP_kinase; cd01169
929506006729	dimer interface [polypeptide binding]; other site
929506006730	substrate binding site [chemical binding]; other site
929506006731	ATP binding site [chemical binding]; other site
929506006732	4-methyl-5-beta-hydroxyethylthiazole (Thz) kinase catalyzes the phosphorylation of the hydroxylgroup of Thz. A reaction that allows cells to recycle Thz into the thiamine biosynthesis pathway, as an alternative to its synthesis from cysteine, tyrosine...; Region: THZ_kinase; cd01170
929506006733	substrate binding site [chemical binding]; other site
929506006734	multimerization interface [polypeptide binding]; other site
929506006735	ATP binding site [chemical binding]; other site
929506006736	Thiamine monophosphate synthase (TMP synthase)/TenI. TMP synthase catalyzes an important step in the thiamine biosynthesis pathway, the substitution of the pyrophosphate of 2-methyl-4-amino-5- hydroxymethylpyrimidine pyrophosphate by 4-methyl-5-; Region: TMP_TenI; cd00564
929506006737	thiamine phosphate binding site [chemical binding]; other site
929506006738	active site
929506006739	pyrophosphate binding site [ion binding]; other site
929506006740	Bacteriophage peptidoglycan hydrolase; Region: Amidase_5; pfam05382
929506006741	glutamate-1-semialdehyde aminotransferase; Provisional; Region: PRK00062
929506006742	Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610
929506006743	inhibitor-cofactor binding pocket; inhibition site
929506006744	pyridoxal 5'-phosphate binding site [chemical binding]; other site
929506006745	catalytic residue [active]
929506006746	Porphobilinogen synthase (PBGS), which is also called delta-aminolevulinic acid dehydratase (ALAD), catalyzes the condensation of two 5-aminolevulinic acid (ALA) molecules to form the pyrrole porphobilinogen (PBG), which is the second step in the...; Region: ALAD_PBGS; cd00384
929506006747	dimer interface [polypeptide binding]; other site
929506006748	active site
929506006749	Schiff base residues; other site
929506006750	Uroporphyrin-III C-methyltransferase (S-Adenosyl-L-methionine:uroporphyrinogen III methyltransferase, SUMT); Region: SUMT; cd11642
929506006751	diphthine synthase; Region: dph5; TIGR00522
929506006752	active site
929506006753	SAM binding site [chemical binding]; other site
929506006754	homodimer interface [polypeptide binding]; other site
929506006755	Uroporphyrinogen-III synthase [Coenzyme metabolism]; Region: HemD; COG1587
929506006756	Uroporphyrinogen-III synthase (HemD) catalyzes the asymmetrical cyclization of tetrapyrrole (linear) to uroporphyrinogen-III, the fourth step in the biosynthesis of heme. This ubiquitous enzyme is present in eukaryotes, bacteria and archaea. Mutations in...; Region: HemD; cd06578
929506006757	active site
929506006758	porphobilinogen deaminase; Reviewed; Region: hemC; PRK00072
929506006759	Hydroxymethylbilane synthase (HMBS), also known as porphobilinogen deaminase (PBGD), is an intermediate enzyme in the biosynthetic pathway of tetrapyrrolic ring systems, such as heme, chlorophylls, and vitamin B12. HMBS catalyzes the conversion of...; Region: HMBS; cd00494
929506006760	domain interfaces; other site
929506006761	active site
929506006762	precorrin-2 dehydrogenase; Reviewed; Region: PRK06718
929506006763	Putative NAD(P)-binding; Region: NAD_binding_7; pfam13241
929506006764	glutamyl-tRNA reductase; Reviewed; Region: hemA; PRK00045
929506006765	NADP-binding domain of glutamyl-tRNA reductase; Region: NAD_bind_Glutamyl_tRNA_reduct; cd05213
929506006766	tRNA; other site
929506006767	putative tRNA binding site [nucleotide binding]; other site
929506006768	putative NADP binding site [chemical binding]; other site
929506006769	Glutamyl-tRNAGlu reductase, dimerisation domain; Region: GlutR_dimer; pfam00745
929506006770	sulfite reductase, subunit C; Region: sulfite_red_C; TIGR02912
929506006771	Nitrite/Sulfite reductase ferredoxin-like half domain; Region: NIR_SIR_ferr; pfam03460
929506006772	4Fe-4S binding domain; Region: Fer4; cl02805
929506006773	Na+-H+ antiporter family; Region: Na_H_antiport_2; pfam13726
929506006774	Na+/H+ antiporter family; Region: Na_H_antiporter; pfam03553
929506006775	Staygreen protein; Region: Staygreen; pfam12638
929506006776	Transposase domain (DUF772); Region: DUF772; pfam05598
929506006777	Transposase DDE domain; Region: DDE_Tnp_1_6; pfam13751
929506006778	glutaminyl-tRNA synthetase; Provisional; Region: PRK05347
929506006779	nucleotidyl transferase superfamily; Region: nt_trans; cl00015
929506006780	active site
929506006781	HIGH motif; other site
929506006782	nucleotide binding site [chemical binding]; other site
929506006783	catalytic core domain of glutaminyl-tRNA synthetase; Region: GlnRS_core; cd00807
929506006784	KMSKS motif; other site
929506006785	tRNA synthetases class I (E and Q), anti-codon binding domain; Region: tRNA-synt_1c_C; pfam03950
929506006786	3-oxoacid CoA-transferase, B subunit; Region: pcaJ_scoB_fam; TIGR02428
929506006787	Acyl CoA:acetate/3-ketoacid CoA transferase, alpha subunit [Lipid metabolism]; Region: AtoD; COG1788
929506006788	Permeases of the drug/metabolite transporter (DMT) superfamily [Carbohydrate transport and metabolism / Amino acid transport and metabolism / General function prediction only]; Region: RhaT; COG0697
929506006789	EamA-like transporter family; Region: EamA; cl17759
929506006790	EamA-like transporter family; Region: EamA; pfam00892
929506006791	Dioxygenases related to 2-nitropropane dioxygenase [General function prediction only]; Region: COG2070
929506006792	2-Nitropropane dioxygenase (NPD), one of the nitroalkane oxidizing enzyme families, catalyzes oxidative denitrification of nitroalkanes to their corresponding carbonyl compounds and nitrites. NDP is a member of the NAD(P)H-dependent flavin oxidoreductase...; Region: NPD_like; cd04730
929506006793	FMN binding site [chemical binding]; other site
929506006794	substrate binding site [chemical binding]; other site
929506006795	putative catalytic residue [active]
929506006796	Transposase domain (DUF772); Region: DUF772; pfam05598
929506006797	Transposase DDE domain; Region: DDE_Tnp_1_6; pfam13751
929506006798	Type I phosphodiesterase / nucleotide pyrophosphatase; Region: Phosphodiest; pfam01663
929506006799	Uncharacterized conserved protein [Function unknown]; Region: COG3379
929506006800	ATPase components of ABC transporters with duplicated ATPase domains [General function prediction only]; Region: Uup; COG0488
929506006801	ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221
929506006802	ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221
929506006803	ABC transporter; Region: ABC_tran_2; pfam12848
929506006804	ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221
929506006805	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
929506006806	Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745
929506006807	active site
929506006808	phosphorylation site [posttranslational modification]
929506006809	intermolecular recognition site; other site
929506006810	dimerization interface [polypeptide binding]; other site
929506006811	Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383
929506006812	DNA binding site [nucleotide binding]
929506006813	Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642
929506006814	Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225
929506006815	dimerization interface [polypeptide binding]; other site
929506006816	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
929506006817	dimer interface [polypeptide binding]; other site
929506006818	phosphorylation site [posttranslational modification]
929506006819	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
929506006820	ATP binding site [chemical binding]; other site
929506006821	Mg2+ binding site [ion binding]; other site
929506006822	G-X-G motif; other site
929506006823	ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136
929506006824	ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255
929506006825	Walker A/P-loop; other site
929506006826	ATP binding site [chemical binding]; other site
929506006827	Q-loop/lid; other site
929506006828	ABC transporter signature motif; other site
929506006829	Walker B; other site
929506006830	D-loop; other site
929506006831	H-loop/switch region; other site
929506006832	MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704
929506006833	FtsX-like permease family; Region: FtsX; pfam02687
929506006834	MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704
929506006835	ABC-type antimicrobial peptide transport system, permease component [Defense mechanisms]; Region: SalY; COG0577
929506006836	FtsX-like permease family; Region: FtsX; pfam02687
929506006837	Translation elongation factors (GTPases) [Translation, ribosomal structure and biogenesis]; Region: FusA; COG0480
929506006838	Tet(M)-like family includes Tet(M), Tet(O), Tet(W), and OtrA, containing tetracycline resistant proteins; Region: TetM_like; cd04168
929506006839	G1 box; other site
929506006840	putative GEF interaction site [polypeptide binding]; other site
929506006841	GTP/Mg2+ binding site [chemical binding]; other site
929506006842	Switch I region; other site
929506006843	G2 box; other site
929506006844	G3 box; other site
929506006845	Switch II region; other site
929506006846	G4 box; other site
929506006847	G5 box; other site
929506006848	EFG_mtEFG_II: this subfamily represents the domain II of elongation factor G (EF-G) in bacteria and, the C-terminus of mitochondrial Elongation factor G1 (mtEFG1) and G2 (mtEFG2)_like proteins found in eukaryotes. During the process of peptide synthesis...; Region: EFG_mtEFG_II; cd04088
929506006849	Elongation factor G, domain IV; Region: EFG_IV; smart00889
929506006850	Tet_C: C-terminus of ribosomal protection proteins Tet(M) and Tet(O). This domain has homology to the C terminal domains of the elongation factors EF-G and EF-2. Tet(M) and Tet(O) catalyze the release of tetracycline (Tc) from the ribosome in a...; Region: Tet_C; cd03711
929506006851	Predicted Zn-dependent peptidases, insulinase-like [General function prediction only]; Region: COG1026
929506006852	Insulinase (Peptidase family M16); Region: Peptidase_M16; pfam00675
929506006853	Peptidase M16 inactive domain; Region: Peptidase_M16_C; pfam05193
929506006854	Peptidase M16C associated; Region: M16C_assoc; pfam08367
929506006855	Peptidase M16 inactive domain; Region: Peptidase_M16_C; pfam05193
929506006856	Exopolysaccharide biosynthesis protein related to N-acetylglucosamine-1-phosphodiester alpha-N-acetylglucosaminidase [Carbohydrate transport and metabolism]; Region: EpsL; COG4632
929506006857	aspartate aminotransferase; Provisional; Region: PRK06836
929506006858	Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609
929506006859	pyridoxal 5'-phosphate binding site [chemical binding]; other site
929506006860	homodimer interface [polypeptide binding]; other site
929506006861	catalytic residue [active]
929506006862	Na+-driven multidrug efflux pump [Defense mechanisms]; Region: NorM; COG0534
929506006863	Uncharacterized subfamily of the multidrug and toxic compound extrusion (MATE) proteins; Region: MATE_like_1; cd13140
929506006864	Insecticidal Crystal Toxin, P42; Region: Toxin_10; pfam05431
929506006865	RT_G2_intron: Reverse transcriptases (RTs) with group II intron origin. RT transcribes DNA using RNA as template. Proteins in this subfamily are found in bacterial and mitochondrial group II introns. Their most probable ancestor was a retrotransposable...; Region: RT_G2_intron; cd01651
929506006866	Reverse transcriptase (RNA-dependent DNA polymerase); Region: RVT_1; pfam00078
929506006867	putative active site [active]
929506006868	putative NTP binding site [chemical binding]; other site
929506006869	putative nucleic acid binding site [nucleotide binding]; other site
929506006870	Group II intron, maturase-specific domain; Region: GIIM; pfam08388
929506006871	transposase/IS protein; Provisional; Region: PRK09183
929506006872	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
929506006873	Walker A motif; other site
929506006874	ATP binding site [chemical binding]; other site
929506006875	Walker B motif; other site
929506006876	arginine finger; other site
929506006877	Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cl17402
929506006878	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG4584
929506006879	DNA binding site [nucleotide binding]
929506006880	Integrase core domain; Region: rve; pfam00665
929506006881	Predicted membrane protein [Function unknown]; Region: COG1511
929506006882	YhgE/Pip N-terminal domain; Region: pip_yhgE_Nterm; TIGR03061
929506006883	YhgE/Pip C-terminal domain; Region: pip_yhgE_Cterm; TIGR03062
929506006884	Aldose 1-epimerase, similar to Lactococcus lactis lacX; Region: Aldose_epim_lacX; cd09024
929506006885	active site
929506006886	catalytic residues [active]
929506006887	Fructose-1-phosphate kinase and related fructose-6-phosphate kinase (PfkB) [Carbohydrate transport and metabolism]; Region: FruK; COG1105
929506006888	1-phosphofructokinase (FruK), minor 6-phosphofructokinase (pfkB) and related sugar kinases. FruK plays an important role in the predominant pathway for fructose utilisation.This group also contains tagatose-6-phophate kinase, an enzyme of the tagatose...; Region: FruK_PfkB_like; cd01164
929506006889	putative substrate binding site [chemical binding]; other site
929506006890	putative ATP binding site [chemical binding]; other site
929506006891	Tagatose-1,6-bisphosphate (TBP) aldolase and related Type B Class II aldolases. TBP aldolase is a tetrameric class II aldolase that catalyzes the reversible condensation of dihydroxyacetone phosphate with glyceraldehyde 3-phsophate to produce tagatose 1; Region: TBP_aldolase_IIB; cd00947
929506006892	fructose-bisphosphate aldolase; Provisional; Region: PRK09197
929506006893	intersubunit interface [polypeptide binding]; other site
929506006894	active site
929506006895	zinc binding site [ion binding]; other site
929506006896	Na+ binding site [ion binding]; other site
929506006897	N-acetylglucosamine-6-phosphate deacetylase [Carbohydrate transport and metabolism]; Region: NagA; COG1820
929506006898	N-acetylglucosamine-6-phosphate deacetylase, NagA, catalyzes the hydrolysis of the N-acetyl group of N-acetyl-glucosamine-6-phosphate (GlcNAc-6-P) to glucosamine 6-phosphate and acetate. This is the first committed step in the biosynthetic pathway to...; Region: NagA; cd00854
929506006899	active site
929506006900	dimer interface [polypeptide binding]; other site
929506006901	putative sugar isomerase, AgaS family; Region: agaS_fam; TIGR02815
929506006902	SIS (Sugar ISomerase) domain repeat 1 found in Glucosamine 6-phosphate synthase (GlmS) and Glucosamine-6-phosphate deaminase (GlmD). The SIS domain is found in many phosphosugar isomerases and phosphosugar binding proteins. GlmS contains a N-terminal...; Region: SIS_GlmS_GlmD_1; cd05008
929506006903	dimer interface [polypeptide binding]; other site
929506006904	active site
929506006905	AgaS-like protein. AgaS contains a SIS (Sugar ISomerase) domain which is found in many phosphosugar isomerases and phosphosugar binding proteins. AgaS is a putative isomerase in Escherichia coli. It is similar to the glucosamine-6-phosphate synthases; Region: SIS_AgaS_like; cd05010
929506006906	putative active site [active]
929506006907	Transcriptional regulators [Transcription]; Region: PhnF; COG2188
929506006908	Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377
929506006909	DNA-binding site [nucleotide binding]; DNA binding site
929506006910	UTRA domain; Region: UTRA; pfam07702
929506006911	Domain of unknown function (DUF202); Region: DUF202; pfam02656
929506006912	anaerobic sulfatase-maturating enzyme; Region: sulfatase_rSAM; TIGR03942
929506006913	Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335
929506006914	FeS/SAM binding site; other site
929506006915	radical SAM additional 4Fe4S-binding SPASM domain; Region: rSAM_more_4Fe4S; TIGR04085
929506006916	Transposase domain (DUF772); Region: DUF772; pfam05598
929506006917	Transposase DDE domain; Region: DDE_Tnp_1_6; pfam13751
929506006918	Predicted N-acetylglucosamine kinase [Carbohydrate transport and metabolism]; Region: COG2971
929506006919	Arylsulfatase A and related enzymes [Inorganic ion transport and metabolism]; Region: AslA; COG3119
929506006920	Sulfatase; Region: Sulfatase; pfam00884
929506006921	Solute carrier 5 family, sodium/glucose transporters and related proteins; solute-binding domain; Region: SLC5sbd; cd10322
929506006922	Predicted symporter [General function prediction only]; Region: DhlC; COG4147
929506006923	Na binding site [ion binding]; other site
929506006924	Sulfatase; Region: Sulfatase; cl17466
929506006925	Arylsulfatase A and related enzymes [Inorganic ion transport and metabolism]; Region: AslA; COG3119
929506006926	putative transporter; Provisional; Region: PRK10484
929506006927	uncharacterized SLC5 subfamily, Escherichia coli YidK-like; solute binding domain; Region: SLC5sbd_YidK; cd10328
929506006928	Na binding site [ion binding]; other site
929506006929	Transcriptional regulators [Transcription]; Region: PhnF; COG2188
929506006930	Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377
929506006931	DNA-binding site [nucleotide binding]; DNA binding site
929506006932	UTRA domain; Region: UTRA; pfam07702
929506006933	Putative redox-active protein (C_GCAxxG_C_C); Region: C_GCAxxG_C_C; pfam09719
929506006934	BCCT family transporter; Region: BCCT; pfam02028
929506006935	Predicted transcriptional regulators [Transcription]; Region: COG1725
929506006936	Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377
929506006937	DNA-binding site [nucleotide binding]; DNA binding site
929506006938	TrkA-C domain; Region: TrkA_C; pfam02080
929506006939	coproporphyrinogen III oxidase; Provisional; Region: PRK05799
929506006940	Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335
929506006941	FeS/SAM binding site; other site
929506006942	Protein of unknown function DUF262; Region: DUF262; pfam03235
929506006943	Uncharacterized conserved protein [Function unknown]; Region: COG3472
929506006944	Trypsin-like serine protease; Many of these are synthesized as inactive precursor zymogens that are cleaved during limited proteolysis to generate their active forms. Alignment contains also inactive enzymes that have substitutions of the catalytic triad...; Region: Tryp_SPc; cl00149
929506006945	DNA-sulfur modification-associated; Region: DndB; cl17621
929506006946	DGQHR domain; Region: DGQHR; TIGR03187
929506006947	hypothetical protein; Provisional; Region: PRK06850
929506006948	This domain is found in phosphoadenosine phosphosulphate (PAPS) reductase enzymes or PAPS sulphotransferase. PAPS reductase is part of the adenine nucleotide alpha hydrolases superfamily also including N type ATP PPases and ATP sulphurylases. A highly...; Region: PAPS_reductase; cd01713
929506006949	Active Sites [active]
929506006950	DNA sulfur modification protein DndD; Region: DNA_S_dndD; TIGR03185
929506006951	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
929506006952	Walker A/P-loop; other site
929506006953	ATP binding site [chemical binding]; other site
929506006954	Domain of unknown function (DUF1832); Region: DUF1832; cl07463
929506006955	Cysteine sulfinate desulfinase/cysteine desulfurase and related enzymes [Amino acid transport and metabolism]; Region: NifS; COG1104
929506006956	cysteine desulfurase NifS; Region: FeS_nifS; TIGR03402
929506006957	pyridoxal 5'-phosphate binding pocket [chemical binding]; other site
929506006958	catalytic residue [active]
929506006959	DNA phosphorothioation-dependent restriction protein DptH; Region: dnd_assoc_2; TIGR03237
929506006960	AAA-like domain; Region: AAA_10; pfam12846
929506006961	DNA phosphorothioation-dependent restriction protein DptG; Region: dnd_assoc_1; TIGR03236
929506006962	Domain of unknown function (DUF4145); Region: DUF4145; pfam13643
929506006963	DNA phosphorothioation-dependent restriction protein DptF; Region: dnd_assoc_3; TIGR03238
929506006964	Nuclease-related domain; Region: NERD; pfam08378
929506006965	AAA domain; Region: AAA_22; pfam13401
929506006966	DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cl17251
929506006967	ATP binding site [chemical binding]; other site
929506006968	putative Mg++ binding site [ion binding]; other site
929506006969	Family description; Region: UvrD_C_2; pfam13538
929506006970	Superfamily I DNA and RNA helicases [DNA replication, recombination, and repair]; Region: UvrD; COG0210
929506006971	H+/gluconate symporter and related permeases [Carbohydrate transport and metabolism / Amino acid transport and metabolism]; Region: GntT; COG2610
929506006972	fructuronate transporter; Provisional; Region: PRK10034; cl15264
929506006973	H+/gluconate symporter and related permeases [Carbohydrate transport and metabolism / Amino acid transport and metabolism]; Region: GntT; COG2610
929506006974	Protein of unknown function, DUF606; Region: DUF606; pfam04657
929506006975	Protein of unknown function, DUF606; Region: DUF606; pfam04657
929506006976	CAT RNA binding domain; Region: CAT_RBD; cl03904
929506006977	PRD domain; Region: PRD; pfam00874
929506006978	PRD domain; Region: PRD; pfam00874
929506006979	Phosphotransferase system IIC components, glucose/maltose/N-acetylglucosamine-specific [Carbohydrate transport and metabolism]; Region: PtsG; COG1263
929506006980	PTS system N-acetyl glucosamine specific transporter subunits IIABC; Provisional; Region: PRK10255
929506006981	PTS_IIB, PTS system, glucose/sucrose specific IIB subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIB_glc; cd00212
929506006982	active site turn [active]
929506006983	phosphorylation site [posttranslational modification]
929506006984	PTS_IIA, PTS system, glucose/sucrose specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIA_glc; cd00210
929506006985	HPr interaction site; other site
929506006986	glycerol kinase (GK) interaction site [polypeptide binding]; other site
929506006987	active site
929506006988	phosphorylation site [posttranslational modification]
929506006989	Histidine-containing phosphocarrier protein (HPr)-like proteins. HPr is a central component of the bacterial phosphoenolpyruvate sugar phosphotransferase system (PTS). The PTS catalyses the phosphorylation of sugar substrates during their translocation...; Region: PTS-HPr_like; cd00367
929506006990	dimerization domain swap beta strand [polypeptide binding]; other site
929506006991	regulatory protein interface [polypeptide binding]; other site
929506006992	active site
929506006993	regulatory phosphorylation site [posttranslational modification]; other site
929506006994	Phosphoenolpyruvate-protein kinase (PTS system EI component in bacteria) [Carbohydrate transport and metabolism]; Region: PtsA; COG1080
929506006995	PEP-utilising enzyme, N-terminal; Region: PEP-utilisers_N; pfam05524
929506006996	PEP-utilising enzyme, mobile domain; Region: PEP-utilizers; pfam00391
929506006997	PEP-utilising enzyme, TIM barrel domain; Region: PEP-utilizers_C; pfam02896
929506006998	DNA topoisomerase III; Provisional; Region: PRK07726
929506006999	TOPRIM_TopoIA_TopoIII: The topoisomerase-primase (TORPIM) domain found in members of the type IA family of DNA topoisomerases (Topo IA) similar to topoisomerase III. Type IA DNA topoisomerases remove (relax) negative supercoils in the DNA by: cleaving...; Region: TOPRIM_TopoIA_TopoIII; cd03362
929506007000	active site
929506007001	putative interdomain interaction site [polypeptide binding]; other site
929506007002	putative metal-binding site [ion binding]; other site
929506007003	putative nucleotide binding site [chemical binding]; other site
929506007004	DNA Topoisomerase, subtype IA; DNA-binding, ATP-binding and catalytic domain of bacterial DNA topoisomerases I and III, and eukaryotic DNA topoisomerase III and eubacterial and archael reverse gyrases. Topoisomerases clevage single or double stranded DNA...; Region: TOP1Ac; cd00186
929506007005	domain I; other site
929506007006	DNA binding groove [nucleotide binding]
929506007007	phosphate binding site [ion binding]; other site
929506007008	domain II; other site
929506007009	domain III; other site
929506007010	nucleotide binding site [chemical binding]; other site
929506007011	catalytic site [active]
929506007012	domain IV; other site
929506007013	dGTP triphosphohydrolase [Nucleotide transport and metabolism]; Region: Dgt; COG0232
929506007014	Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077
929506007015	Zn2+ binding site [ion binding]; other site
929506007016	Mg2+ binding site [ion binding]; other site
929506007017	Phosphohydrolase-associated domain; Region: HD_assoc; pfam13286
929506007018	Phosphohydrolase-associated domain; Region: HD_assoc; pfam13286
929506007019	prolyl-tRNA synthetase; Provisional; Region: PRK08661
929506007020	Prolyl-tRNA synthetase (ProRS) class II core catalytic domain. ProRS is a homodimer. It is responsible for the attachment of proline to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for ATP-dependent...; Region: ProRS_core_arch_euk; cd00778
929506007021	dimer interface [polypeptide binding]; other site
929506007022	motif 1; other site
929506007023	active site
929506007024	motif 2; other site
929506007025	motif 3; other site
929506007026	ProRS Prolyl-anticodon binding domain, long version found predominantly in eukaryotes and archaea. ProRS belongs to class II aminoacyl-tRNA synthetases (aaRS). This alignment contains the anticodon binding domain, which is responsible for specificity in...; Region: ProRS_anticodon_zinc; cd00862
929506007027	anticodon binding site; other site
929506007028	zinc-binding site [ion binding]; other site
929506007029	QueT transporter; Region: QueT; pfam06177
929506007030	Methyltransferase domain; Region: Methyltransf_31; pfam13847
929506007031	Putative rRNA methylase; Region: rRNA_methylase; pfam06962
929506007032	bacteriocin-associated integral membrane (putative immunity) protein; Region: bact_immun_7tm; TIGR01654
929506007033	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
929506007034	ABC transporter signature motif; other site
929506007035	Walker B; other site
929506007036	D-loop; other site
929506007037	H-loop/switch region; other site
929506007038	Bacterial Ig-like domain (group 2); Region: Big_2; cl02708
929506007039	Glycosaminoglycan (GAG) polysaccharide lyase family. This family consists of a group of secreted bacterial lyase enzymes capable of acting on glycosaminoglycans, such as hyaluronan and chondroitin, in the extracellular matrix of host tissues; Region: GAG_Lyase; cd01083
929506007040	substrate binding site [chemical binding]; other site
929506007041	catalytic residues [active]
929506007042	Macro domain, a high-affinity ADP-ribose binding module found in a variety of proteins as a stand-alone domain or in combination with other domains like in histone macroH2A and some PARPs (poly ADP-ribose polymerases). Some macro domains recognize poly...; Region: Macro; cl00019
929506007043	ADP-ribose binding site [chemical binding]; other site
929506007044	Soluble lytic murein transglycosylase and related regulatory proteins (some contain LysM/invasin domains) [Cell envelope biogenesis, outer membrane]; Region: MltE; COG0741
929506007045	Lytic Transglycosylase (LT)  and Goose Egg White Lysozyme (GEWL) domain. Members include the soluble and insoluble membrane-bound LTs in bacteria, the LTs in bacteriophage lambda, as well as, the eukaryotic "goose-type" lysozymes (GEWL).  LTs...; Region: LT_GEWL; cd00254
929506007046	N-acetyl-D-glucosamine binding site [chemical binding]; other site
929506007047	catalytic residue [active]
929506007048	Class I aldolases; Region: Aldolase_Class_I; cl17187
929506007049	catalytic residue [active]
929506007050	Peptidase family M48; Region: Peptidase_M48; cl12018
929506007051	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
929506007052	binding surface
929506007053	TPR motif; other site
929506007054	Tetratricopeptide repeat; Region: TPR_16; pfam13432
929506007055	Probable zinc-binding domain; Region: zf-trcl; pfam13451
929506007056	Predicted hydrolase (metallo-beta-lactamase superfamily) [General function prediction only]; Region: ComEC; COG2333
929506007057	Metallo-beta-lactamase superfamily; Region: Lactamase_B; smart00849
929506007058	Ribosomal protein L4/L1 family; Region: Ribosomal_L4; cl00325
929506007059	Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225
929506007060	dimerization interface [polypeptide binding]; other site
929506007061	Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer); Region: MA; smart00283
929506007062	Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386
929506007063	dimer interface [polypeptide binding]; other site
929506007064	putative CheW interface [polypeptide binding]; other site
929506007065	3-ketoacyl-(acyl-carrier-protein) reductase; Provisional; Region: fabG; PRK05565
929506007066	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
929506007067	NAD(P) binding site [chemical binding]; other site
929506007068	active site
929506007069	ATP:corrinoid adenosyltransferase [Coenzyme metabolism]; Region: BtuR; COG2109
929506007070	ATP:corrinoid adenosyltransferase BtuR/CobO/CobP. This family consists of the BtuR, CobO, CobP proteins all of which are Cob(I)alamin (vitamin B12) adenosyltransferase, which is involved in cobalamin (vitamin B12) biosynthesis. This enzyme is a homodimer; Region: CobA_CobO_BtuR; cd00561
929506007071	homodimer interface [polypeptide binding]; other site
929506007072	Walker A motif; other site
929506007073	ATP binding site [chemical binding]; other site
929506007074	hydroxycobalamin binding site [chemical binding]; other site
929506007075	Walker B motif; other site
929506007076	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
929506007077	S-adenosylmethionine binding site [chemical binding]; other site
929506007078	Uncharacterized homologs of Site-2 protease (S2P), zinc metalloproteases (MEROPS family M50) which cleave transmembrane domains of substrate proteins, regulating intramembrane proteolysis (RIP) of diverse signal transduction mechanisms. Members of the...; Region: S2P-M50_like_1; cd06158
929506007079	Peptidase family M50; Region: Peptidase_M50; pfam02163
929506007080	active site
929506007081	putative substrate binding region [chemical binding]; other site
929506007082	Exopolysaccharide biosynthesis protein related to N-acetylglucosamine-1-phosphodiester alpha-N-acetylglucosaminidase [Carbohydrate transport and metabolism]; Region: EpsL; COG4632
929506007083	Cell envelope-related transcriptional attenuator domain; Region: LytR_cpsA_psr; pfam03816
929506007084	NYN ribonuclease and ATPase of PhoH family domains [General    function prediction only]; Region: COG1875
929506007085	PIN domain of bacterial Smg6-like homologs with PhoH-like ATPase domains; Region: PIN_PhoHL-ATPase; cd09883
929506007086	putative active site [active]
929506007087	PhoH-like protein; Region: PhoH; pfam02562
929506007088	Ferric uptake regulator(Fur) and related metalloregulatory proteins; typically iron-dependent, DNA-binding repressors and activators; Region: Fur_like; cd07153
929506007089	metal binding site 2 [ion binding]; metal-binding site
929506007090	putative DNA binding helix; other site
929506007091	metal binding site 1 [ion binding]; metal-binding site
929506007092	dimer interface [polypeptide binding]; other site
929506007093	structural Zn2+ binding site [ion binding]; other site
929506007094	YihA (EngB) GTPase family; Region: YihA_EngB; cd01876
929506007095	G1 box; other site
929506007096	GTP/Mg2+ binding site [chemical binding]; other site
929506007097	Switch I region; other site
929506007098	G2 box; other site
929506007099	G3 box; other site
929506007100	Switch II region; other site
929506007101	G4 box; other site
929506007102	G5 box; other site
929506007103	ATP-dependent Lon protease, bacterial type [Posttranslational modification, protein turnover, chaperones]; Region: Lon; COG0466
929506007104	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
929506007105	Walker A motif; other site
929506007106	ATP binding site [chemical binding]; other site
929506007107	Walker B motif; other site
929506007108	arginine finger; other site
929506007109	C-terminal, D2-small domain, of ClpB protein; Region: ClpB_D2-small; smart01086
929506007110	Lon protease (S16) C-terminal proteolytic domain; Region: Lon_C; pfam05362
929506007111	ATP-dependent protease LonB; Region: spore_lonB; TIGR02902
929506007112	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
929506007113	Walker A motif; other site
929506007114	ATP binding site [chemical binding]; other site
929506007115	Walker B motif; other site
929506007116	arginine finger; other site
929506007117	Lon protease (S16) C-terminal proteolytic domain; Region: Lon_C; pfam05362
929506007118	ATP-dependent protease ATP-binding subunit ClpX; Provisional; Region: clpX; PRK05342
929506007119	ClpX C4-type zinc finger; Region: zf-C4_ClpX; pfam06689
929506007120	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
929506007121	Walker A motif; other site
929506007122	ATP binding site [chemical binding]; other site
929506007123	Walker B motif; other site
929506007124	C-terminal, D2-small domain, of ClpB protein; Region: ClpB_D2-small; smart01086
929506007125	Clp protease; Region: CLP_protease; pfam00574
929506007126	Caseinolytic protease (ClpP) is an ATP-dependent, highly conserved serine protease; Region: S14_ClpP_2; cd07017
929506007127	oligomer interface [polypeptide binding]; other site
929506007128	active site residues [active]
929506007129	trigger factor; Provisional; Region: tig; PRK01490
929506007130	FKBP-type peptidyl-prolyl cis-trans isomerase; Region: FKBP_C; pfam00254
929506007131	Bacterial trigger factor protein (TF) C-terminus; Region: Trigger_C; pfam05698
929506007132	Sugar phosphate isomerases/epimerases [Carbohydrate transport and metabolism]; Region: IolE; COG1082
929506007133	AP endonuclease family 2; These endonucleases play a role in DNA repair. Cleave phosphodiester bonds at apurinic or apyrimidinic sites; the alignment also contains hexulose-6-phosphate isomerases, enzymes that catalyze the epimerization of...; Region: AP2Ec; cl12060
929506007134	DNA interaction; other site
929506007135	Metal-binding active site; metal-binding site
929506007136	carbamoyl phosphate synthase large subunit; Reviewed; Region: carB; PRK05294
929506007137	Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289
929506007138	Carbamoyl-phosphate synthase L chain, ATP binding domain; Region: CPSase_L_D2; pfam02786
929506007139	Carbamoyl-phosphate synthetase large chain, oligomerisation domain; Region: CPSase_L_D3; pfam02787
929506007140	Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289
929506007141	ATP-grasp domain; Region: ATP-grasp_4; cl17255
929506007142	Methylglyoxal synthase-like domain from type II glutamine-dependent carbamoyl phosphate synthetase (CSP). CSP, a CarA and CarB heterodimer, catalyzes the production of carbamoyl phosphate which is subsequently employed in the metabolic pathways...; Region: MGS_CPS_II; cd01424
929506007143	IMP binding site; other site
929506007144	dimer interface [polypeptide binding]; other site
929506007145	interdomain contacts; other site
929506007146	partial ornithine binding site; other site
929506007147	carbamoyl phosphate synthase small subunit; Reviewed; Region: PRK12564
929506007148	Carbamoyl-phosphate synthase small chain, CPSase domain; Region: CPSase_sm_chain; smart01097
929506007149	Small chain of the glutamine-dependent form of carbamoyl phosphate synthase, CPSase II; Region: GATase1_CPSase; cd01744
929506007150	catalytic site [active]
929506007151	subunit interface [polypeptide binding]; other site
929506007152	glycyl-radical enzyme activating protein family; Region: PFLE_PFLC; TIGR02494
929506007153	The HCP family of iron-sulfur proteins includes hybrid cluster protein (HCP), acetyl-CoA synthase (ACS), and carbon monoxide dehydrogenase (CODH), all of which contain [Fe4-S4] metal clusters at their active sites. These proteins have a conserved...; Region: HCP_like; cl14655
929506007154	Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335
929506007155	FeS/SAM binding site; other site
929506007156	glycyl radical enzyme, PFL2/glycerol dehydratase family; Region: PFL2-3; TIGR01774
929506007157	Pyruvate formate lyase 2 and related enzymes; Region: PFL2_DhaB_BssA; cd01677
929506007158	dimer interface [polypeptide binding]; other site
929506007159	active site
929506007160	glycine loop; other site
929506007161	signal peptidase I, bacterial type; Region: sigpep_I_bact; TIGR02227
929506007162	The S26 Type I signal peptidase (SPase; LepB; leader peptidase B; leader peptidase I; EC 3.4.21.89) family members are essential membrane-bound serine proteases that function to cleave the amino-terminal signal peptide extension from proteins that are...; Region: S26_SPase_I; cd06530
929506007163	Catalytic site [active]
929506007164	Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223
929506007165	active site
929506007166	Dihydroorotate dehydrogenase (DHOD) class 1B FMN-binding domain. DHOD catalyzes the oxidation of (S)-dihydroorotate to orotate. This is the fourth step and the only redox reaction in the de novo biosynthesis of UMP, the precursor of all pyrimidine...; Region: DHOD_1B_like; cd04740
929506007167	dihydroorotate dehydrogenase (subfamily 1) family protein; Region: pyrD_sub1_fam; TIGR01037
929506007168	heterodimer interface [polypeptide binding]; other site
929506007169	active site
929506007170	FMN binding site [chemical binding]; other site
929506007171	homodimer interface [polypeptide binding]; other site
929506007172	substrate binding site [chemical binding]; other site
929506007173	dihydroorotate dehydrogenase electron transfer subunit; Reviewed; Region: PRK00054
929506007174	FAD/NAD binding domain in the electron transfer subunit of dihydroorotate dehydrogenase. Dihydroorotate dehydrogenases (DHODs) catalyze the only redox reaction in pyrimidine de novo biosynthesis. They catalyze the oxidation of (S)-dihydroorotate to...; Region: DHOD_e_trans; cd06218
929506007175	FAD binding pocket [chemical binding]; other site
929506007176	FAD binding motif [chemical binding]; other site
929506007177	phosphate binding motif [ion binding]; other site
929506007178	beta-alpha-beta structure motif; other site
929506007179	NAD binding pocket [chemical binding]; other site
929506007180	Iron coordination center [ion binding]; other site
929506007181	Orotidine 5'-phosphate decarboxylase (ODCase) is a dimeric enzyme that decarboxylates orotidine 5'-monophosphate (OMP) to form uridine 5'-phosphate (UMP), an essential step in the pyrimidine biosynthetic pathway. In mammals, UMP synthase...; Region: OMP_decarboxylase_like; cd04725
929506007182	active site
929506007183	dimer interface [polypeptide binding]; other site
929506007184	dihydroorotase; Validated; Region: pyrC; PRK09357
929506007185	Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281
929506007186	Dihydroorotase (DHOase), subgroup IIa; DHOases catalyze the reversible interconversion of carbamoyl aspartate to dihydroorotate, a key reaction in pyrimidine biosynthesis. This subgroup also contains proteins that lack the active site, like unc-33, a C; Region: DHOase_IIa; cd01317
929506007187	active site
929506007188	aspartate carbamoyltransferase catalytic subunit; Provisional; Region: pyrB; PRK00856
929506007189	Aspartate/ornithine carbamoyltransferase, carbamoyl-P binding domain; Region: OTCace_N; pfam02729
929506007190	Aspartate/ornithine carbamoyltransferase, Asp/Orn binding domain; Region: OTCace; pfam00185
929506007191	Leucine Rich repeats (2 copies); Region: LRR_4; pfam12799
929506007192	Leucine Rich repeats (2 copies); Region: LRR_4; pfam12799
929506007193	Leucine Rich repeats (2 copies); Region: LRR_4; pfam12799
929506007194	Leucine Rich repeats (2 copies); Region: LRR_4; pfam12799
929506007195	Leucine Rich repeats (2 copies); Region: LRR_4; pfam12799
929506007196	Leucine Rich repeats (2 copies); Region: LRR_4; pfam12799
929506007197	Leucine Rich repeats (2 copies); Region: LRR_4; pfam12799
929506007198	Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 residue sequence motifs present in many proteins that participate in protein-protein interactions and have different functions and cellular locations. LRRs correspond...; Region: LRR_RI; cl15309
929506007199	Leucine Rich repeats (2 copies); Region: LRR_4; pfam12799
929506007200	Substrate binding site [chemical binding]; other site
929506007201	Leucine Rich repeats (2 copies); Region: LRR_4; pfam12799
929506007202	Leucine rich repeat; Region: LRR_8; pfam13855
929506007203	ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136
929506007204	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
929506007205	Walker A/P-loop; other site
929506007206	ATP binding site [chemical binding]; other site
929506007207	Q-loop/lid; other site
929506007208	ABC transporter signature motif; other site
929506007209	Walker B; other site
929506007210	D-loop; other site
929506007211	H-loop/switch region; other site
929506007212	Accessory gene regulator B; Region: AgrB; pfam04647
929506007213	cyclic lactone autoinducer peptide; Region: quorum_AgrD; TIGR04223
929506007214	Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase; Region: HATPase_c; pfam02518
929506007215	ATP binding site [chemical binding]; other site
929506007216	G-X-G motif; other site
929506007217	Response regulator of the LytR/AlgR family [Transcription / Signal transduction mechanisms]; Region: LytT; COG3279
929506007218	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
929506007219	active site
929506007220	phosphorylation site [posttranslational modification]
929506007221	intermolecular recognition site; other site
929506007222	dimerization interface [polypeptide binding]; other site
929506007223	LytTr DNA-binding domain; Region: LytTR; smart00850
929506007224	Acyl CoA:acetate/3-ketoacid CoA transferase [Lipid metabolism]; Region: COG4670
929506007225	Coenzyme A transferase; Region: CoA_trans; smart00882
929506007226	Coenzyme A transferase; Region: CoA_trans; cl17247
929506007227	acetoacetate metabolism regulatory protein AtoC; Provisional; Region: PRK11361
929506007228	PAS domain; Region: PAS; smart00091
929506007229	putative active site [active]
929506007230	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
929506007231	Walker A motif; other site
929506007232	ATP binding site [chemical binding]; other site
929506007233	Walker B motif; other site
929506007234	arginine finger; other site
929506007235	Bacterial regulatory protein, Fis family; Region: HTH_8; pfam02954
929506007236	Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223
929506007237	active site
929506007238	Na+/H+-dicarboxylate symporters [Energy production and conversion]; Region: GltP; COG1301
929506007239	Sodium:dicarboxylate symporter family; Region: SDF; pfam00375
929506007240	NTPase/HAM1.  This family consists of the HAM1 protein and pyrophosphate-releasing xanthosine/ inosine triphosphatase. HAM1 protects the cell against mutagenesis by the base analog 6-N-hydroxylaminopurine (HAP) in E. Coli and S. cerevisiae. A...; Region: HAM1; cd00515
929506007241	active site
929506007242	dimerization interface [polypeptide binding]; other site
929506007243	AIR synthase (PurM) related protein, subgroup 1 of unknown function. The family of PurM related proteins includes Hydrogen expression/formation protein HypE, AIR synthases, FGAM synthase and Selenophosphate synthetase (SelD). They all contain two...; Region: PurM-like1; cd06061
929506007244	Thiamine monophosphate kinase [Coenzyme metabolism]; Region: ThiL; COG0611
929506007245	dimerization interface [polypeptide binding]; other site
929506007246	putative ATP binding site [chemical binding]; other site
929506007247	Collagenase and related proteases [Posttranslational modification, protein turnover, chaperones]; Region: COG0826
929506007248	Phosphotransferase system cellobiose-specific component IIC [Carbohydrate transport and metabolism]; Region: CelB; COG1455
929506007249	InsA N-terminal domain; Region: Zn_Tnp_IS1; pfam03811
929506007250	DDE domain; Region: DDE_Tnp_IS240; pfam13610
929506007251	Integrase core domain; Region: rve; pfam00665
929506007252	Integrase core domain; Region: rve_3; pfam13683
929506007253	PTS_IIB_chitobiose_lichenan: subunit IIB of enzyme II (EII) of the N,N-diacetylchitobiose-specific and lichenan-specific phosphoenolpyruvate:carbohydrate phosphotransferase system (PTS). In these systems, EII is either a lichenan- or an N; Region: PTS_IIB_chitobiose_lichenan; cd05564
929506007254	active site
929506007255	PTS_IIA, PTS system, lactose/cellobiose specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_lac; cd00215
929506007256	methionine cluster; other site
929506007257	active site
929506007258	phosphorylation site [posttranslational modification]
929506007259	metal binding site [ion binding]; metal-binding site
929506007260	Laminarinase, member of the glycosyl hydrolase family 16; Region: GH16_laminarinase_like; cd08023
929506007261	active site
929506007262	catalytic residues [active]
929506007263	cellobiose phosphotransferase system IIC component; Reviewed; Region: celD; PRK09592
929506007264	Phosphotransferase system cellobiose-specific component IIC [Carbohydrate transport and metabolism]; Region: CelB; COG1455
929506007265	Transcriptional regulators [Transcription]; Region: RpiR; COG1737
929506007266	Helix-turn-helix domain, rpiR family; Region: HTH_6; pfam01418
929506007267	RpiR-like protein. RpiR contains a SIS (Sugar ISomerase) domain, which is found in many phosphosugar isomerases and phosphosugar binding proteins. In E. coli, rpiR negatively regulates the expression of rpiB gene. Both rpiB and rpiA are ribose phosphate...; Region: SIS_RpiR; cd05013
929506007268	putative active site [active]
929506007269	The substrate-binding component of an ABC-type oligopetide import system contains the type 2 periplasmic binding fold; Region: PBP2_OppA; cd08504
929506007270	peptide binding site [polypeptide binding]; other site
929506007271	Bacterial extracellular solute-binding proteins, family 5 Middle; Region: SBP_bac_5; pfam00496
929506007272	aspartyl/glutamyl-tRNA amidotransferase subunit B; Validated; Region: gatB; PRK05477
929506007273	GatB/GatE catalytic domain; Region: GatB_N; pfam02934
929506007274	GatB domain; Region: GatB_Yqey; smart00845
929506007275	Asp-tRNAAsn/Glu-tRNAGln amidotransferase A subunit and related amidases [Translation, ribosomal structure and biogenesis]; Region: GatA; COG0154
929506007276	aspartyl/glutamyl-tRNA amidotransferase subunit A; Reviewed; Region: gatA; PRK00012
929506007277	aspartyl/glutamyl-tRNA amidotransferase subunit C; Reviewed; Region: gatC; PRK00034
929506007278	diaminopimelate dehydrogenase; Region: DAP-DH; TIGR01921
929506007279	NAD-dependent DNA ligase LigA; Validated; Region: ligA; PRK07956
929506007280	NAD+ dependent DNA ligase adenylation domain. DNA ligases catalyze the crucial step of joining the breaks in duplex DNA during DNA replication, repair and recombination, utilizing either ATP or NAD(+) as a cofactor, but using the same basic reaction...; Region: LIGANc; cd00114
929506007281	nucleotide binding pocket [chemical binding]; other site
929506007282	K-X-D-G motif; other site
929506007283	catalytic site [active]
929506007284	NAD-dependent DNA ligase OB-fold domain; Region: DNA_ligase_OB; pfam03120
929506007285	NAD-dependent DNA ligase C4 zinc finger domain; Region: DNA_ligase_ZBD; pfam03119
929506007286	endonuclease III; includes endonuclease III (DNA-(apurinic or apyrimidinic site) lyase), alkylbase DNA glycosidases (Alka-family) and other DNA glycosidases; Region: ENDO3c; cl14786
929506007287	Breast Cancer Suppressor Protein (BRCA1), carboxy-terminal domain. The BRCT domain is found within many DNA damage repair and cell cycle checkpoint proteins. The unique diversity of this domain superfamily allows BRCT modules to interact forming homo...; Region: BRCT; cd00027
929506007288	Dimer interface [polypeptide binding]; other site
929506007289	BRCT sequence motif; other site
929506007290	Superfamily I DNA and RNA helicases [DNA replication, recombination, and repair]; Region: UvrD; COG0210
929506007291	Part of AAA domain; Region: AAA_19; pfam13245
929506007292	Family description; Region: UvrD_C_2; pfam13538
929506007293	Trp repressor protein; Region: Trp_repressor; cl17266
929506007294	16S rRNA uridine-516 pseudouridylate synthase and related pseudouridylate synthases [Translation, ribosomal structure and biogenesis]; Region: RsuA; COG1187
929506007295	S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site;  Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165
929506007296	RNA binding surface [nucleotide binding]; other site
929506007297	Pseudouridine synthase, Escherichia coli RsuA like; Region: PseudoU_synth_RsuA; cd02553
929506007298	active site
929506007299	uracil binding [chemical binding]; other site
929506007300	triple tyrosine motif-containing protein; Provisional; Region: PRK14081
929506007301	Y_Y_Y domain; Region: Y_Y_Y; pfam07495
929506007302	Y_Y_Y domain; Region: Y_Y_Y; pfam07495
929506007303	Y_Y_Y domain; Region: Y_Y_Y; pfam07495
929506007304	Y_Y_Y domain; Region: Y_Y_Y; pfam07495
929506007305	Y_Y_Y domain; Region: Y_Y_Y; pfam07495
929506007306	pullulanase, type I; Region: pulA_typeI; TIGR02104
929506007307	Early set domain associated with the catalytic domain of pullulanase (also called dextrinase and alpha-dextrin endo-1,6-alpha glucosidase); Region: E_set_Pullulanase; cd02860
929506007308	Alpha amylase catalytic domain found in Pullulanase (also called dextrinase; alpha-dextrin endo-1,6-alpha glucosidase), limit dextrinase, and related proteins; Region: AmyAc_Pullulanase_LD-like; cd11341
929506007309	Ca binding site [ion binding]; other site
929506007310	active site
929506007311	catalytic site [active]
929506007312	hypothetical protein; Validated; Region: PRK00124
929506007313	InsA N-terminal domain; Region: Zn_Tnp_IS1; pfam03811
929506007314	DDE domain; Region: DDE_Tnp_IS240; pfam13610
929506007315	Integrase core domain; Region: rve; pfam00665
929506007316	Integrase core domain; Region: rve_3; pfam13683
929506007317	glucose-6-phosphate isomerase; Provisional; Region: pgi; PRK14097
929506007318	Phosphoglucose isomerase (PGI) contains two SIS (Sugar ISomerase) domains. This classification is based on the alignment of the first SIS domain. PGI is a multifunctional enzyme which as an intracellular dimer catalyzes the reversible isomerization of...; Region: SIS_PGI_1; cd05015
929506007319	active site
929506007320	dimer interface [polypeptide binding]; other site
929506007321	Phosphoglucose isomerase (PGI) contains two SIS (Sugar ISomerase) domains. This classification is based on the alignment of the second SIS domain. PGI is a multifunctional enzyme which as an intracellular dimer catalyzes the reversible isomerization of...; Region: SIS_PGI_2; cd05016
929506007322	dimer interface [polypeptide binding]; other site
929506007323	active site
929506007324	Predicted xylanase/chitin deacetylase [Carbohydrate transport and metabolism]; Region: CDA1; COG0726
929506007325	Putative catalytic NodB homology domain of PgaB, IcaB, and similar proteins which consist of a deformed (beta/alpha)8 barrel fold with 5- or 6-strands; Region: CE4_NodB_like_5s_6s; cd10918
929506007326	putative active site [active]
929506007327	putative metal binding site [ion binding]; other site
929506007328	TPR repeat; Region: TPR_11; pfam13414
929506007329	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
929506007330	binding surface
929506007331	TPR motif; other site
929506007332	TPR repeat; Region: TPR_11; pfam13414
929506007333	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
929506007334	binding surface
929506007335	Tetratricopeptide repeat; Region: TPR_12; pfam13424
929506007336	TPR motif; other site
929506007337	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain [Posttranslational modification, protein turnover, chaperones]; Region: DegQ; COG0265
929506007338	Protein of unknown function (DUF3021); Region: DUF3021; pfam11457
929506007339	LytTr DNA-binding domain; Region: LytTR; smart00850
929506007340	GMP synthase; Reviewed; Region: guaA; PRK00074
929506007341	Type 1 glutamine amidotransferase (GATase1) domain found in GMP synthetase; Region: GATase1_GMP_Synthase; cd01742
929506007342	AMP/PPi binding site [chemical binding]; other site
929506007343	candidate oxyanion hole; other site
929506007344	catalytic triad [active]
929506007345	potential glutamine specificity residues [chemical binding]; other site
929506007346	The C-terminal domain of GMP synthetase. It contains two subdomains; the ATP pyrophosphatase domain which closes to the N-termial and the dimerization domain at C-terminal end. The ATP-PPase is a twisted, five-stranded parallel beta-sheet sandwiched...; Region: GMP_synthase_C; cd01997
929506007347	ATP Binding subdomain [chemical binding]; other site
929506007348	Ligand Binding sites [chemical binding]; other site
929506007349	Dimerization subdomain; other site
929506007350	inosine 5'-monophosphate dehydrogenase; Reviewed; Region: PRK05567
929506007351	TIM barrel proteins share a structurally conserved phosphate binding motif and in general share an eight beta/alpha closed barrel structure. Specific for this family is the conserved phosphate binding site at the edges of strands 7 and 8. The phosphate...; Region: TIM_phosphate_binding; cl17186
929506007352	This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains in the inosine 5' monophosphate dehydrogenase (IMPDH) protein.  IMPDH is an essential enzyme that catalyzes the first step unique to GTP synthesis, playing a...; Region: CBS_pair_IMPDH; cd04601
929506007353	IMPDH: The catalytic domain of the inosine monophosphate dehydrogenase. IMPDH catalyzes the NAD-dependent oxidation of inosine 5'-monophosphate (IMP) to xanthosine 5' monophosphate (XMP). It is a rate-limiting step in the de novo synthesis of...; Region: IMPDH; cd00381
929506007354	active site
929506007355	tRNA 2-thiocytidine biosynthesis protein TtcA; Provisional; Region: PRK10696
929506007356	This is a subfamily of Adenine nucleotide alpha hydrolases superfamily.Adeninosine nucleotide alpha hydrolases superfamily  includes N type ATP PPases and ATP sulphurylases. It forms a apha/beta/apha fold which  binds to Adenosine group.  This subfamily; Region: Alpha_ANH_like_II; cd01993
929506007357	Ligand Binding Site [chemical binding]; other site
929506007358	chaperonin GroEL; Reviewed; Region: groEL; PRK12849
929506007359	GroEL_like type I chaperonin. Chaperonins are involved in productive folding of proteins. They share a common general morphology, a double toroid of 2 stacked rings, each composed of 7-9 subunits. The symmetry of type I is seven-fold and they are found...; Region: GroEL; cd03344
929506007360	ring oligomerisation interface [polypeptide binding]; other site
929506007361	ATP/Mg binding site [chemical binding]; other site
929506007362	stacking interactions; other site
929506007363	hinge regions; other site
929506007364	Chaperonin 10 Kd subunit (cpn10 or GroES); Cpn10 cooperates with chaperonin 60 (cpn60 or GroEL), an ATPase, to assist the folding and assembly of proteins and is found in eubacterial cytosol, as well as in the matrix of mitochondria and chloroplasts. It...; Region: cpn10; cd00320
929506007365	oligomerisation interface [polypeptide binding]; other site
929506007366	mobile loop; other site
929506007367	roof hairpin; other site
929506007368	[FeFe] hydrogenase, group B1/B3; Region: FeFe_hydrog_B1; TIGR04105
929506007369	RPB11 and RPB3 subunits of RNA polymerase; Region: RNAP_RPB11_RPB3; cl11409
929506007370	4Fe-4S binding domain; Region: Fer4; pfam00037
929506007371	Iron only hydrogenase large subunit, C-terminal domain; Region: Fe_hyd_lg_C; pfam02906
929506007372	8-oxoguanine DNA glycosylase, N-terminal domain; Region: OGG_N; pfam07934
929506007373	8-oxoguanine DNA-glycosylase (ogg); Region: ogg; TIGR00588
929506007374	endonuclease III; includes endonuclease III (DNA-(apurinic or apyrimidinic site) lyase), alkylbase DNA glycosidases (Alka-family) and other DNA glycosidases; Region: ENDO3c; cd00056
929506007375	minor groove reading motif; other site
929506007376	helix-hairpin-helix signature motif; other site
929506007377	substrate binding pocket [chemical binding]; other site
929506007378	active site
929506007379	putative oxidoreductase; Provisional; Region: PRK12831
929506007380	The HCP family of iron-sulfur proteins includes hybrid cluster protein (HCP), acetyl-CoA synthase (ACS), and carbon monoxide dehydrogenase (CODH), all of which contain [Fe4-S4] metal clusters at their active sites. These proteins have a conserved...; Region: HCP_like; cl14655
929506007381	NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450
929506007382	ferredoxin-NADP(+) reductase subunit alpha; Reviewed; Region: PRK06222
929506007383	FAD/NAD binding domain in the electron transfer subunit of dihydroorotate dehydrogenase-like proteins. Dihydroorotate dehydrogenases (DHODs) catalyze the only redox reaction in pyrimidine de novo biosynthesis. They catalyze the oxidation of (S)...; Region: DHOD_e_trans_like1; cd06219
929506007384	FAD binding pocket [chemical binding]; other site
929506007385	FAD binding motif [chemical binding]; other site
929506007386	phosphate binding motif [ion binding]; other site
929506007387	beta-alpha-beta structure motif; other site
929506007388	NAD binding pocket [chemical binding]; other site
929506007389	Iron coordination center [ion binding]; other site
929506007390	Alcohol dehydrogenase, class IV [Energy production and conversion]; Region: EutG; COG1454
929506007391	NADPH-dependent butanol dehydrogenase involved in the butanol and ethanol formation pathway in bacteria; Region: NADPH_BDH; cd08179
929506007392	putative active site [active]
929506007393	metal binding site [ion binding]; metal-binding site
929506007394	DNA-binding transcriptional regulator DhaR; Provisional; Region: PRK11388
929506007395	GAF domain; Region: GAF; pfam01590
929506007396	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
929506007397	Walker A motif; other site
929506007398	ATP binding site [chemical binding]; other site
929506007399	Walker B motif; other site
929506007400	arginine finger; other site
929506007401	Bacterial regulatory protein, Fis family; Region: HTH_8; pfam02954
929506007402	3-hydroxybutyryl-CoA dehydrogenase; Validated; Region: PRK05808
929506007403	3-hydroxyacyl-CoA dehydrogenase, NAD binding domain; Region: 3HCDH_N; pfam02737
929506007404	3-hydroxyacyl-CoA dehydrogenase, C-terminal domain; Region: 3HCDH; pfam00725
929506007405	Electron transfer flavoprotein, alpha subunit [Energy production and conversion]; Region: FixB; COG2025
929506007406	The electron transfer flavoprotein (ETF) serves as a specific electron acceptor for various mitochondrial dehydrogenases. ETF transfers electrons to the main respiratory chain via ETF-ubiquinone oxidoreductase. ETF is an heterodimer that consists of an...; Region: ETF_alpha; cd01715
929506007407	Electron transfer flavoprotein FAD-binding domain; Region: ETF_alpha; pfam00766
929506007408	The electron transfer flavoprotein (ETF) serves as a specific electron acceptor for various mitochondrial dehydrogenases. ETF transfers electrons to the main respiratory chain via ETF-ubiquinone oxidoreductase. ETF is an heterodimer that consists of an...; Region: ETF_beta; cd01714
929506007409	Ligand binding site [chemical binding]; other site
929506007410	Electron transfer flavoprotein domain; Region: ETF; pfam01012
929506007411	Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960
929506007412	Short chain acyl-CoA dehydrogenases and eukaryotic short/branched chain acyl-CoA dehydrogenases; Region: SCAD_SBCAD; cd01158
929506007413	FAD binding site [chemical binding]; other site
929506007414	homotetramer interface [polypeptide binding]; other site
929506007415	substrate binding pocket [chemical binding]; other site
929506007416	catalytic base [active]
929506007417	3-hydroxybutyryl-CoA dehydratase; Validated; Region: PRK05809
929506007418	Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558
929506007419	substrate binding site [chemical binding]; other site
929506007420	oxyanion hole (OAH) forming residues; other site
929506007421	trimer interface [polypeptide binding]; other site
929506007422	redox-sensing transcriptional repressor Rex; Provisional; Region: PRK05472
929506007423	Putative DNA-binding protein N-terminus; Region: Put_DNA-bind_N; pfam06971
929506007424	CoA binding domain; Region: CoA_binding; pfam02629
929506007425	ATPase components of ABC transporters with duplicated ATPase domains [General function prediction only]; Region: Uup; COG0488
929506007426	ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221
929506007427	ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221
929506007428	ABC transporter; Region: ABC_tran_2; pfam12848
929506007429	ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221
929506007430	Transposase, Mutator family; Region: Transposase_mut; pfam00872
929506007431	MULE transposase domain; Region: MULE; pfam10551
929506007432	The substrate-binding domain of an ABC-type nickel/oligopeptide-like import system contains the type 2 periplasmic binding fold; Region: PBP2_NikA_DppA_OppA_like; cl01709
929506007433	Bacterial extracellular solute-binding proteins, family 5 Middle; Region: SBP_bac_5; pfam00496
929506007434	UGMP family protein; Validated; Region: PRK09604
929506007435	tRNA threonylcarbamoyl adenosine modification protein YeaZ; Region: T6A_YeaZ; TIGR03725
929506007436	Endodeoxyribonuclease RusA; Region: RusA; pfam05866
929506007437	Thioredoxin reductase [Posttranslational modification, protein turnover, chaperones]; Region: TrxB; COG0492
929506007438	Helical backbone metal receptor (TroA-like domain). These proteins have been shown to function in the ABC transport of ferric siderophores and metal ions such as Mn2+, Fe3+, Cu2+ and/or Zn2+.  Their ligand binding site is formed in the interface between...; Region: TroA-like; cl00262
929506007439	Periplasmic solute binding protein family; Region: SBP_bac_9; pfam01297
929506007440	intersubunit interface [polypeptide binding]; other site
929506007441	Transposase domain (DUF772); Region: DUF772; pfam05598
929506007442	Transposase DDE domain; Region: DDE_Tnp_1_6; pfam13751
929506007443	Chromate transporter; Region: Chromate_transp; pfam02417
929506007444	Chromate transporter; Region: Chromate_transp; pfam02417
929506007445	Four helix bundle sensory module for signal transduction; Region: 4HB_MCP_1; pfam12729
929506007446	Methyl-accepting chemotaxis protein [Cell motility and secretion / Signal transduction mechanisms]; Region: Tar; COG0840
929506007447	Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225
929506007448	dimerization interface [polypeptide binding]; other site
929506007449	Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386
929506007450	Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386
929506007451	dimer interface [polypeptide binding]; other site
929506007452	putative CheW interface [polypeptide binding]; other site
929506007453	Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077
929506007454	Zn2+ binding site [ion binding]; other site
929506007455	Mg2+ binding site [ion binding]; other site
929506007456	c-di-GMP phosphodiesterase class II (HD-GYP domain) [Signal transduction mechanisms]; Region: COG2206
929506007457	Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077
929506007458	Zn2+ binding site [ion binding]; other site
929506007459	Mg2+ binding site [ion binding]; other site
929506007460	Predicted ATPase or kinase [General function prediction only]; Region: COG0802
929506007461	tRNA threonylcarbamoyl adenosine modification protein YeaZ; Region: T6A_YeaZ; TIGR03725
929506007462	Glycoprotease family; Region: Peptidase_M22; pfam00814
929506007463	ribosomal-protein-alanine acetyltransferase; Region: rimI; TIGR01575
929506007464	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301
929506007465	Coenzyme A binding pocket [chemical binding]; other site
929506007466	Predicted membrane protein [Function unknown]; Region: COG3601
929506007467	Protein of unknown function (DUF3816); Region: DUF3816; pfam12822
929506007468	Transcriptional accessory protein [Transcription]; Region: Tex; COG2183
929506007469	Tex-like protein N-terminal domain; Region: Tex_N; pfam09371
929506007470	Likely ribonuclease with RNase H fold; Region: YqgFc; smart00732
929506007471	S1_Tex: The C-terminal S1 domain of a transcription accessory factor called Tex, which has been characterized in Bordetella pertussis and Pseudomonas aeruginosa. The tex gene is essential in Bortella pertusis and is named for its role in toxin expression; Region: S1_Tex; cd05685
929506007472	RNA binding site [nucleotide binding]; other site
929506007473	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3677
929506007474	InsA N-terminal domain; Region: Zn_Tnp_IS1; pfam03811
929506007475	DDE domain; Region: DDE_Tnp_IS240; pfam13610
929506007476	Integrase core domain; Region: rve; pfam00665
929506007477	Integrase core domain; Region: rve_3; pfam13683
929506007478	Zinc peptidases M18, M20, M28, and M42; Region: Zinc_peptidase_like; cl14876
929506007479	M28 Zn-Peptidases containing a PA domain insert; Region: M28_like_PA; cd03877
929506007480	Peptidase family M28; Region: Peptidase_M28; pfam04389
929506007481	metal binding site [ion binding]; metal-binding site
929506007482	Protein of unknown function (DUF1657); Region: DUF1657; pfam07870
929506007483	peptide chain release factor 2; Provisional; Region: PRK05589
929506007484	This domain is found in peptide chain release factors; Region: PCRF; smart00937
929506007485	RF-1 domain; Region: RF-1; pfam00472
929506007486	preprotein translocase subunit SecA; Reviewed; Region: PRK12904
929506007487	Lyase class I_like superfamily: contains the lyase class I family, histidine ammonia-lyase and phenylalanine ammonia-lyase, which catalyze similar beta-elimination reactions; Region: Lyase_I_like; cl00013
929506007488	DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046
929506007489	ATP binding site [chemical binding]; other site
929506007490	putative Mg++ binding site [ion binding]; other site
929506007491	SecA preprotein cross-linking domain; Region: SecA_PP_bind; smart00958
929506007492	Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cl17351
929506007493	nucleotide binding region [chemical binding]; other site
929506007494	ATP-binding site [chemical binding]; other site
929506007495	SEC-C motif; Region: SEC-C; pfam02810
929506007496	Haloacid dehalogenase-like hydrolase; Region: Hydrolase_6; pfam13344
929506007497	RaiA ("ribosome-associated inhibitor A", also known as Protein Y (PY), YfiA, and SpotY,  is a stress-response protein that binds the ribosomal subunit interface and arrests translation by interfering with aminoacyl-tRNA binding to the ribosomal...; Region: RaiA; cd00552
929506007498	30S subunit binding site; other site
929506007499	Predicted amidophosphoribosyltransferases [General function prediction only]; Region: ComFC; COG1040
929506007500	Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223
929506007501	active site
929506007502	Superfamily II DNA/RNA helicase required for DNA uptake (late competence protein) [DNA replication, recombination, and repair]; Region: comFA; COG4098
929506007503	helicase, putative, RecD/TraA family; Region: recD_rel; TIGR01448
929506007504	AAA domain; Region: AAA_30; pfam13604
929506007505	Family description; Region: UvrD_C_2; pfam13538
929506007506	S-adenosylmethionine synthetase; Validated; Region: PRK05250
929506007507	S-adenosylmethionine synthetase, N-terminal domain; Region: S-AdoMet_synt_N; pfam00438
929506007508	S-adenosylmethionine synthetase, central domain; Region: S-AdoMet_synt_M; pfam02772
929506007509	S-adenosylmethionine synthetase, C-terminal domain; Region: S-AdoMet_synt_C; pfam02773
929506007510	This is a subfamily of Adenine nucleotide alpha hydrolases superfamily.Adeninosine nucleotide alpha hydrolases superfamily  includes N type ATP PPases and ATP sulphurylases. It forms a apha/beta/apha fold which  binds to Adenosine group.  This subfamily; Region: Alpha_ANH_like_II; cd01993
929506007511	Ligand Binding Site [chemical binding]; other site
929506007512	Protein of unknown function (DUF1256); Region: DUF1256; pfam06866
929506007513	rod shape-determining protein Mbl; Provisional; Region: PRK13928
929506007514	MreB and similar proteins; Region: MreB_like; cd10225
929506007515	nucleotide binding site [chemical binding]; other site
929506007516	Mg binding site [ion binding]; other site
929506007517	putative protofilament interaction site [polypeptide binding]; other site
929506007518	RodZ interaction site [polypeptide binding]; other site
929506007519	Stage III sporulation protein D; Region: SpoIIID; pfam12116
929506007520	Membrane proteins related to metalloendopeptidases [Cell envelope biogenesis, outer membrane]; Region: NlpD; COG0739
929506007521	Peptidase family M23; Region: Peptidase_M23; pfam01551
929506007522	stage II sporulation protein D; Region: spore_II_D; TIGR02870
929506007523	Stage II sporulation protein; Region: SpoIID; pfam08486
929506007524	UDP-N-acetylglucosamine 1-carboxyvinyltransferase; Region: murA; TIGR01072
929506007525	UDP-N-acetylglucosamine enolpyruvyl transferase catalyzes enolpyruvyl transfer as part of the first step in the biosynthesis of peptidoglycan, a component of the bacterial cell wall. The reaction is phosphoenolpyruvate + UDP-N-acetyl-D-glucosamine =...; Region: UdpNAET; cd01555
929506007526	hinge; other site
929506007527	active site
929506007528	Protein of unknown function (DUF1779); Region: DUF1779; pfam08680
929506007529	F0F1 ATP synthase subunit epsilon; Provisional; Region: atpC; PRK13450
929506007530	mitochondrial ATP synthase delta subunit; Region: F1-ATPase_delta; cd12152
929506007531	gamma subunit interface [polypeptide binding]; other site
929506007532	epsilon subunit interface [polypeptide binding]; other site
929506007533	LBP interface [polypeptide binding]; other site
929506007534	F0F1 ATP synthase subunit beta; Validated; Region: PRK09280
929506007535	ATP synthase alpha/beta family, beta-barrel domain; Region: ATP-synt_ab_N; pfam02874
929506007536	F1 ATP synthase beta subunit, nucleotide-binding domain. The F-ATPase is found in bacterial plasma membranes, mitochondrial inner membranes and in chloroplast thylakoid membranes. It has also been found in the archaea Methanosarcina barkeri. It uses a...; Region: F1-ATPase_beta; cd01133
929506007537	alpha subunit interaction interface [polypeptide binding]; other site
929506007538	Walker A motif; other site
929506007539	ATP binding site [chemical binding]; other site
929506007540	Walker B motif; other site
929506007541	inhibitor binding site; inhibition site
929506007542	ATP synthase alpha/beta chain, C terminal domain; Region: ATP-synt_ab_C; pfam00306
929506007543	mitochondrial ATP synthase gamma subunit; Region: F1-ATPase_gamma; cd12151
929506007544	core domain interface [polypeptide binding]; other site
929506007545	delta subunit interface [polypeptide binding]; other site
929506007546	epsilon subunit interface [polypeptide binding]; other site
929506007547	F0F1 ATP synthase subunit alpha; Validated; Region: PRK09281
929506007548	ATP synthase alpha/beta family, beta-barrel domain; Region: ATP-synt_ab_N; pfam02874
929506007549	F1 ATP synthase alpha, central domain. The F-ATPase is found in bacterial plasma membranes, mitochondrial inner membranes and in chloroplast thylakoid membranes. It has also been found in the archaea Methanosarcina barkeri. It uses a proton gradient to...; Region: F1_ATPase_alpha; cd01132
929506007550	beta subunit interaction interface [polypeptide binding]; other site
929506007551	Walker A motif; other site
929506007552	ATP binding site [chemical binding]; other site
929506007553	Walker B motif; other site
929506007554	ATP synthase alpha/beta chain, C terminal domain; Region: ATP-synt_ab_C; pfam00306
929506007555	F0F1 ATP synthase subunit delta; Validated; Region: PRK05758
929506007556	ATP synthase delta (OSCP) subunit; Region: OSCP; pfam00213
929506007557	F0F1 ATP synthase subunit B; Provisional; Region: PRK13461
929506007558	F0F1 ATP synthase subunit B; Validated; Region: PRK05759
929506007559	F0F1 ATP synthase subunit C; Provisional; Region: PRK13469
929506007560	F0F1 ATP synthase subunit A; Validated; Region: PRK05815
929506007561	putative acyltransferase; Provisional; Region: PRK05790
929506007562	Thiolase are ubiquitous enzymes that catalyze the reversible thiolytic cleavage of 3-ketoacyl-CoA into acyl-CoA and acetyl-CoA, a 2-step reaction involving a covalent intermediate formed with a catalytic cysteine. They are found in prokaryotes and...; Region: thiolase; cd00751
929506007563	dimer interface [polypeptide binding]; other site
929506007564	active site
929506007565	UDP-N-acetylglucosamine 2-epimerase [Cell envelope biogenesis, outer membrane]; Region: WecB; COG0381
929506007566	Bacterial members of the UDP-N-Acetylglucosamine (GlcNAc) 2-Epimerase  family are known to catalyze the reversible interconversion of UDP-GlcNAc and UDP-N-acetylmannosamine (UDP-ManNAc). The enzyme serves to produce an activated form of ManNAc residues; Region: GT1_UDP-GlcNAc_2-Epimerase; cd03786
929506007567	active site
929506007568	homodimer interface [polypeptide binding]; other site
929506007569	UDP-N-acetylmuramyl pentapeptide phosphotransferase/UDP-N- acetylglucosamine-1-phosphate transferase [Cell envelope biogenesis, outer membrane]; Region: Rfe; COG0472
929506007570	This subfamily contains Escherichia coli WecA, Bacillus subtilis TagO and related proteins. WecA is an UDP-N-acetylglucosamine (GlcNAc):undecaprenyl-phosphate (Und-P) GlcNAc-1-phosphate transferase that catalyzes the formation of a phosphodiester bond...; Region: GT_WecA_like; cd06853
929506007571	Mg++ binding site [ion binding]; other site
929506007572	putative catalytic motif [active]
929506007573	substrate binding site [chemical binding]; other site
929506007574	Deoxycytidylate deaminase [Nucleotide transport and metabolism]; Region: ComEB; COG2131
929506007575	active site
929506007576	Zn binding site [ion binding]; other site
929506007577	Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223
929506007578	active site
929506007579	ribose-5-phosphate isomerase B; Provisional; Region: PRK05571
929506007580	Low molecular weight phosphatase family; Region: LMWPc; cd00115
929506007581	Low molecular weight phosphotyrosine protein phosphatase; Region: LMWPc; pfam01451
929506007582	active site
929506007583	Putative translation factor (SUA5) [Translation, ribosomal structure and biogenesis]; Region: SUA5; COG0009
929506007584	Putative GTP-binding controlling metal-binding; Region: SUA5; pfam03481
929506007585	Predicted divalent heavy-metal cations transporter [Inorganic ion transport and metabolism]; Region: COG0428; cl00437
929506007586	peptide chain release factor 1; Validated; Region: prfA; PRK00591
929506007587	This domain is found in peptide chain release factors; Region: PCRF; smart00937
929506007588	RF-1 domain; Region: RF-1; pfam00472
929506007589	N5-glutamine S-adenosyl-L-methionine-dependent methyltransferase; Provisional; Region: PRK09328
929506007590	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
929506007591	S-adenosylmethionine binding site [chemical binding]; other site
929506007592	Predicted metal-dependent enzyme [General function prediction only]; Region: COG3872
929506007593	thymidine kinase; Provisional; Region: PRK04296
929506007594	50S ribosomal protein L31; Reviewed; Region: rpmE; PRK00019
929506007595	transcription termination factor Rho; Provisional; Region: rho; PRK09376
929506007596	Rho termination factor, N-terminal domain; Region: Rho_N; smart00959
929506007597	Rho_CSD: Rho protein cold-shock domain (CSD). Rho protein is a transcription termination factor in most bacteria. In bacteria, there are two distinct mechanisms for mRNA transcription termination. In intrinsic termination, RNA polymerase and nascent mRNA...; Region: Rho_CSD; cd04459
929506007598	RNA binding site [nucleotide binding]; other site
929506007599	Transcription termination factor rho is a bacterial ATP-dependent RNA/DNA helicase. It is a homohexamer. Each monomer consists of an N-terminal domain of the OB fold, which is responsible for binding to cysteine rich nucleotides. This alignment is of the...; Region: rho_factor; cd01128
929506007600	multimer interface [polypeptide binding]; other site
929506007601	Walker A motif; other site
929506007602	ATP binding site [chemical binding]; other site
929506007603	Walker B motif; other site
929506007604	CTP synthetase; Validated; Region: pyrG; PRK05380
929506007605	CTP synthetase (CTPs) is a two-domain protein, which consists of an N-terminal synthetase domain and C-terminal glutaminase domain. The enzymes hydrolyze the amide bond of glutamine to ammonia and glutamate at the glutaminase domains and transfer nascent...; Region: CTGs; cd03113
929506007606	Catalytic site [active]
929506007607	active site
929506007608	UTP binding site [chemical binding]; other site
929506007609	Type 1 glutamine amidotransferase (GATase1) domain found in Cytidine Triphosphate Synthetase; Region: GATase1_CTP_Synthase; cd01746
929506007610	active site
929506007611	putative oxyanion hole; other site
929506007612	catalytic triad [active]
929506007613	Domain of unknown function (DUF1934); Region: DUF1934; pfam09148
929506007614	Predicted tRNA(5-methylaminomethyl-2-thiouridylate) methyltransferase, contains the PP-loop ATPase domain [Translation, ribosomal structure and biogenesis]; Region: TrmU; COG0482
929506007615	ThiI is required for thiazole synthesis in the thiamine biosynthesis pathway. It belongs to the Adenosine Nucleotide Hydrolysis suoerfamily and predicted to bind to Adenosine nucleotide; Region: ThiI; cd01712
929506007616	Ligand Binding Site [chemical binding]; other site
929506007617	Domain of unknown function (DUF814); Region: DUF814; pfam05670
929506007618	D-alanyl-alanine synthetase A; Reviewed; Region: ddl; PRK01966
929506007619	D-ala D-ala ligase N-terminus; Region: Dala_Dala_lig_N; pfam01820
929506007620	D-ala D-ala ligase C-terminus; Region: Dala_Dala_lig_C; pfam07478
929506007621	germination protein YpeB; Region: spore_YpeB; TIGR02889
929506007622	Stage II sporulation protein R (spore_II_R); Region: Spore_II_R; pfam09551
929506007623	germination protein, Ger(x)C family; Region: spore_ger_x_C; TIGR02887
929506007624	Spore germination B3/ GerAC like, C-terminal; Region: Spore_GerAC; pfam05504
929506007625	Spore germination protein; Region: Spore_permease; cl17796
929506007626	Bacillus/Clostridium GerA spore germination protein; Region: GerA; pfam03323
929506007627	4-diphosphocytidyl-2-C-methyl-D-erythritol kinase; Provisional; Region: ipk; PRK00128
929506007628	GHMP kinases N terminal domain; Region: GHMP_kinases_N; pfam00288
929506007629	GHMP kinases C terminal; Region: GHMP_kinases_C; pfam08544
929506007630	Domain of unknown function (DUF3794); Region: DUF3794; pfam12673
929506007631	Domain of unknown function (DUF3794); Region: DUF3794; pfam12673
929506007632	Domain of unknown function (DUF3794); Region: DUF3794; pfam12673
929506007633	Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118
929506007634	Protein of unknown function (DUF1021); Region: DUF1021; pfam06257
929506007635	YabG peptidase U57; Region: Peptidase_U57; pfam05582
929506007636	Aminoglycoside 3'-phosphotransferase (APH) and Choline Kinase (ChoK) family. The APH/ChoK family is part of a larger superfamily that includes the catalytic domains of other kinases, such as the typical serine/threonine/tyrosine protein kinases (PKs)...; Region: APH_ChoK_like; cl17270
929506007637	spore coat protein, CotS family; Region: spore_CotS; TIGR02906
929506007638	active site
929506007639	ATP binding site [chemical binding]; other site
929506007640	Aminoglycoside 3'-phosphotransferase (APH) and Choline Kinase (ChoK) family. The APH/ChoK family is part of a larger superfamily that includes the catalytic domains of other kinases, such as the typical serine/threonine/tyrosine protein kinases (PKs)...; Region: APH_ChoK_like; cd05120
929506007641	substrate binding site [chemical binding]; other site
929506007642	This family is most closely related to the GT1 family of glycosyltransferases. mtfB (mannosyltransferase B) in E. coli has been shown to direct the growth of the O9-specific polysaccharide chain. It transfers two mannoses into the position 3 of the...; Region: GT1_mtfB_like; cd03809
929506007643	Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438
929506007644	Cysteine synthase [Amino acid transport and metabolism]; Region: CysK; COG0031
929506007645	CBS_like: This subgroup includes Cystathionine beta-synthase (CBS) and Cysteine synthase. CBS is a unique heme-containing enzyme that catalyzes a pyridoxal 5'-phosphate (PLP)-dependent condensation of serine and homocysteine to give cystathionine; Region: CBS_like; cd01561
929506007646	dimer interface [polypeptide binding]; other site
929506007647	pyridoxal 5'-phosphate binding site [chemical binding]; other site
929506007648	catalytic residue [active]
929506007649	Cobalt chelatase (CbiK); Region: CbiK; pfam06180
929506007650	Anaerobic cobalamin biosynthetic cobalt chelatase (CbiK), N-terminal domain. CbiK is part of the cobalt-early path for cobalamin biosynthesis. It catalyzes the insertion of cobalt into the oxidized form of precorrin-2, factor II (sirohydrochlorin), the...; Region: CbiK_N; cd03412
929506007651	active site
929506007652	C-terminal domain interface [polypeptide binding]; other site
929506007653	Anaerobic cobalamin biosynthetic cobalt chelatase (CbiK), C-terminal domain. CbiK is part of the cobalt-early path for cobalamin biosynthesis. It catalyzes the insertion of cobalt into the oxidized form of precorrin-2, factor II (sirohydrochlorin), the...; Region: CbiK_C; cd03413
929506007654	active site
929506007655	N-terminal domain interface [polypeptide binding]; other site
929506007656	Precorrin-6x reductase [Coenzyme metabolism]; Region: CobK; COG2099
929506007657	cobalt-precorrin-6x reductase; Reviewed; Region: PRK08057
929506007658	Precorrin-3B C(17)-methyltransferase (CobJ/CbiH); Region: Precorrin_3B_C17_MT; cd11646
929506007659	active site
929506007660	SAM binding site [chemical binding]; other site
929506007661	homodimer interface [polypeptide binding]; other site
929506007662	cobalamin biosynthesis protein CbiG; Validated; Region: PRK05788
929506007663	Cobalamin synthesis G N-terminal; Region: CbiG_N; pfam11760
929506007664	Cobalamin biosynthesis central region; Region: CbiG_mid; pfam11761
929506007665	Cobalamin synthesis G C-terminus; Region: CbiG_C; pfam01890
929506007666	Precorrin-4 C11-methyltransferase (CbiF/CobM); Region: Precorrin-4_C11-MT; cd11641
929506007667	active site
929506007668	SAM binding site [chemical binding]; other site
929506007669	homodimer interface [polypeptide binding]; other site
929506007670	Precorrin-2 C20-methyltransferase, also named CobI or CbiL; Region: Precorrin_2_C20_MT; cd11645
929506007671	active site
929506007672	SAM binding site [chemical binding]; other site
929506007673	homodimer interface [polypeptide binding]; other site
929506007674	Precorrin-6B methylase 2 [Coenzyme metabolism]; Region: CobL; COG2242
929506007675	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
929506007676	S-adenosylmethionine binding site [chemical binding]; other site
929506007677	Precorrin-6Y methyltransferase, the cobalamin biosynthesis enzyme CbiE; Region: Precorrin-6Y-methylase; cd11644
929506007678	Diphthamide biosynthesis methyltransferase [Translation, ribosomal structure and biogenesis]; Region: DPH5; COG1798
929506007679	active site
929506007680	putative homodimer interface [polypeptide binding]; other site
929506007681	SAM binding site [chemical binding]; other site
929506007682	cobalt-precorrin-6A synthase; Reviewed; Region: cbiD; PRK00075
929506007683	cobalt-precorrin-8X methylmutase; Validated; Region: cbiC; cl00913
929506007684	precorrin-8X methylmutase; Validated; Region: cbiC; PRK05575
929506007685	cobyrinic acid a,c-diamide synthase; Validated; Region: PRK01077
929506007686	The Fer4_NifH superfamily contains a variety of proteins which share a common ATP-binding domain. Functionally, proteins in this superfamily use the energy from hydrolysis of NTP to transfer electron or ion; Region: Fer4_NifH; cl17203
929506007687	Type 1 glutamine amidotransferase (GATase1) domain found in Cobyrinic Acid a,c-Diamide Synthase; Region: GATase1_CobB; cd03130
929506007688	catalytic triad [active]
929506007689	spore coat protein, CotS family; Region: spore_CotS; TIGR02906
929506007690	Aminoglycoside 3'-phosphotransferase (APH) and Choline Kinase (ChoK) family. The APH/ChoK family is part of a larger superfamily that includes the catalytic domains of other kinases, such as the typical serine/threonine/tyrosine protein kinases (PKs)...; Region: APH_ChoK_like; cd05120
929506007691	substrate binding site [chemical binding]; other site
929506007692	spore coat protein, CotS family; Region: spore_CotS; TIGR02906
929506007693	spore coat protein YsxE; Region: spore_ysxE; TIGR02904
929506007694	spore coat protein, CotS family; Region: spore_CotS; TIGR02906
929506007695	Aminoglycoside 3'-phosphotransferase (APH) and Choline Kinase (ChoK) family. The APH/ChoK family is part of a larger superfamily that includes the catalytic domains of other kinases, such as the typical serine/threonine/tyrosine protein kinases (PKs)...; Region: APH_ChoK_like; cd05120
929506007696	Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438
929506007697	This family is most closely related to the GT1 family of glycosyltransferases. mtfB (mannosyltransferase B) in E. coli has been shown to direct the growth of the O9-specific polysaccharide chain. It transfers two mannoses into the position 3 of the...; Region: GT1_mtfB_like; cd03809
929506007698	Sensory domain found in PocR; Region: PocR; pfam10114
929506007699	Predicted sensor domain [Signal transduction mechanisms / Transcription]; Region: PocR; COG4936
929506007700	Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386
929506007701	dimer interface [polypeptide binding]; other site
929506007702	Methyl-accepting chemotaxis protein [Cell motility and secretion / Signal transduction mechanisms]; Region: Tar; COG0840
929506007703	putative CheW interface [polypeptide binding]; other site
929506007704	4Fe-4S binding domain; Region: Fer4_6; pfam12837
929506007705	4Fe-4S dicluster domain; Region: Fer4_7; pfam12838
929506007706	cAMP-binding proteins - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases [Signal transduction mechanisms]; Region: Crp; COG0664
929506007707	effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038
929506007708	ligand binding site [chemical binding]; other site
929506007709	flexible hinge region; other site
929506007710	Crp-like helix-turn-helix domain; Region: HTH_Crp_2; pfam13545
929506007711	hybrid cluster protein; Provisional; Region: PRK05290
929506007712	The HCP family of iron-sulfur proteins includes hybrid cluster protein (HCP), acetyl-CoA synthase (ACS), and carbon monoxide dehydrogenase (CODH), all of which contain [Fe4-S4] metal clusters at their active sites. These proteins have a conserved...; Region: HCP_like; cl14655
929506007713	ACS interaction site; other site
929506007714	CODH interaction site; other site
929506007715	Hybrid cluster protein (HCP), formerly known as prismane, is thought to play a role in nitrogen metabolism but its specific function is unknown. HCP has three structural domains, an N-terminal alpha-helical domain, and two similar domains comprising a...; Region: HCP; cd01914
929506007716	hybrid metal cluster; other site
929506007717	Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386
929506007718	dimer interface [polypeptide binding]; other site
929506007719	Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer); Region: MA; smart00283
929506007720	putative CheW interface [polypeptide binding]; other site
929506007721	MCP-signal associated domain; Region: MCPsignal_assoc; pfam13682
929506007722	Cation transporter/ATPase, N-terminus; Region: Cation_ATPase_N; pfam00690
929506007723	Cation transport ATPase [Inorganic ion transport and metabolism]; Region: MgtA; COG0474
929506007724	E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122
929506007725	Putative hydrolase of sodium-potassium ATPase alpha subunit; Region: Hydrolase_like2; pfam13246
929506007726	Soluble P-type ATPase [General function prediction only]; Region: COG4087
929506007727	Cation transporting ATPase, C-terminus; Region: Cation_ATPase_C; pfam00689
929506007728	FOG: LysM repeat [Cell envelope biogenesis, outer membrane]; Region: LytE; COG1388
929506007729	Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118
929506007730	Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427
929506007731	active site
929506007732	motif I; other site
929506007733	motif II; other site
929506007734	Mannose-1-phosphate guanylyltransferase [Cell envelope biogenesis, outer membrane]; Region: {ManC}; COG0836
929506007735	Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394
929506007736	Cupin domain; Region: Cupin_2; cl17218
929506007737	Site-specific recombinases, DNA invertase Pin homologs [DNA replication, recombination, and repair]; Region: PinR; COG1961
929506007738	Serine Recombinase family, catalytic domain; a DNA binding domain may be present either N- or C-terminal to the catalytic domain. These enzymes perform site-specific recombination of DNA molecules by a concerted, four-strand cleavage and rejoining...; Region: Ser_Recombinase; cl02788
929506007739	catalytic residues [active]
929506007740	catalytic nucleophile [active]
929506007741	Recombinase; Region: Recombinase; pfam07508
929506007742	Recombinase zinc beta ribbon domain; Region: Zn_ribbon_recom; pfam13408
929506007743	Domain of unknown function (DUF4368); Region: DUF4368; pfam14287
929506007744	NAD(P)H:flavin oxidoreductase-like family 1.  A subfamily of the nitroreductase family containing uncharacterized proteins that are similar to nitroreductase. Nitroreductase catalyzes the reduction of nitroaromatic compounds such as nitrotoluenes; Region: NADPH_oxidoreductase_1; cd02150
929506007745	putative FMN binding site [chemical binding]; other site
929506007746	Recombinase zinc beta ribbon domain; Region: Zn_ribbon_recom; pfam13408
929506007747	Lactate dehydrogenase and related dehydrogenases [Energy production and conversion / Coenzyme metabolism / General function prediction only]; Region: LdhA; COG1052
929506007748	Putative glycerate dehydrogenase and related proteins of the D-specific 2-hydroxy dehydrogenase family; Region: GDH_like_1; cd12161
929506007749	putative ligand binding site [chemical binding]; other site
929506007750	putative NAD binding site [chemical binding]; other site
929506007751	catalytic site [active]
929506007752	Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394
929506007753	active site
929506007754	putative acyltransferase; Provisional; Region: PRK05790
929506007755	Thiolase are ubiquitous enzymes that catalyze the reversible thiolytic cleavage of 3-ketoacyl-CoA into acyl-CoA and acetyl-CoA, a 2-step reaction involving a covalent intermediate formed with a catalytic cysteine. They are found in prokaryotes and...; Region: thiolase; cd00751
929506007756	dimer interface [polypeptide binding]; other site
929506007757	active site
929506007758	3-hydroxybutyryl-CoA dehydrogenase; Validated; Region: PRK05808
929506007759	3-hydroxyacyl-CoA dehydrogenase, NAD binding domain; Region: 3HCDH_N; pfam02737
929506007760	3-hydroxyacyl-CoA dehydrogenase, C-terminal domain; Region: 3HCDH; pfam00725
929506007761	glycerol kinase; Provisional; Region: glpK; PRK00047
929506007762	Escherichia coli glycerol kinase-like proteins; belongs to the FGGY family of carbohydrate kinases; Region: FGGY_EcGK_like; cd07786
929506007763	N- and C-terminal domain interface [polypeptide binding]; other site
929506007764	active site
929506007765	MgATP binding site [chemical binding]; other site
929506007766	catalytic site [active]
929506007767	metal binding site [ion binding]; metal-binding site
929506007768	glycerol binding site [chemical binding]; other site
929506007769	homotetramer interface [polypeptide binding]; other site
929506007770	homodimer interface [polypeptide binding]; other site
929506007771	FBP binding site [chemical binding]; other site
929506007772	protein IIAGlc interface [polypeptide binding]; other site
929506007773	Glycerol uptake facilitator and related permeases (Major Intrinsic Protein Family) [Carbohydrate transport and metabolism]; Region: GlpF; COG0580
929506007774	amphipathic channel; other site
929506007775	Asn-Pro-Ala signature motifs; other site
929506007776	Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386
929506007777	dimer interface [polypeptide binding]; other site
929506007778	putative CheW interface [polypeptide binding]; other site
929506007779	ABC transporter, phosphonate, periplasmic substrate-binding protein; Region: Phosphonate-bd; pfam12974
929506007780	Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of  substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134
929506007781	substrate binding pocket [chemical binding]; other site
929506007782	membrane-bound complex binding site; other site
929506007783	hinge residues; other site
929506007784	glycerol kinase; Provisional; Region: glpK; PRK00047
929506007785	Escherichia coli glycerol kinase-like proteins; belongs to the FGGY family of carbohydrate kinases; Region: FGGY_EcGK_like; cd07786
929506007786	N- and C-terminal domain interface [polypeptide binding]; other site
929506007787	active site
929506007788	MgATP binding site [chemical binding]; other site
929506007789	catalytic site [active]
929506007790	metal binding site [ion binding]; metal-binding site
929506007791	glycerol binding site [chemical binding]; other site
929506007792	homotetramer interface [polypeptide binding]; other site
929506007793	homodimer interface [polypeptide binding]; other site
929506007794	FBP binding site [chemical binding]; other site
929506007795	protein IIAGlc interface [polypeptide binding]; other site
929506007796	Glycerol uptake facilitator and related permeases (Major Intrinsic Protein Family) [Carbohydrate transport and metabolism]; Region: GlpF; COG0580
929506007797	amphipathic channel; other site
929506007798	Asn-Pro-Ala signature motifs; other site
929506007799	Molybdopterin oxidoreductase Fe4S4 domain; Region: Molybdop_Fe4S4; smart00926
929506007800	Protein of unknown function (DUF1667); Region: DUF1667; pfam07892
929506007801	NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500
929506007802	Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox_2; pfam07992
929506007803	Predicted dehydrogenase [General function prediction only]; Region: COG0579
929506007804	hydroxyglutarate oxidase; Provisional; Region: PRK11728
929506007805	BFD-like [2Fe-2S] binding domain; Region: Fer2_BFD; pfam04324
929506007806	Glycerol-3-phosphate responsive antiterminator; Region: G3P_antiterm; cl00852
929506007807	YcxB-like protein; Region: YcxB; pfam14317
929506007808	proline aminopeptidase P II; Provisional; Region: PRK10879
929506007809	Aminopeptidase P, N-terminal domain; Region: AMP_N; smart01011
929506007810	Prolidase. E.C. 3.4.13.9. Also known as Xaa-Pro dipeptidase, X-Pro dipeptidase, proline dipeptidase., imidodipeptidase, peptidase D, gamma-peptidase. Catalyses hydrolysis of Xaa-Pro dipeptides; also acts on aminoacyl-hydroxyproline analogs. No action on...; Region: Prolidase; cd01087
929506007811	active site
929506007812	2-phosphosulfolactate phosphatase; Provisional; Region: PRK00886
929506007813	Phosphosulfolactate phosphohydrolase and related enzymes [Coenzyme metabolism / General function prediction only]; Region: COG2045
929506007814	Cold-Shock Protein (CSP) contains an S1-like cold-shock domain (CSD) that is found in eukaryotes, prokaryotes, and archaea.  CSP's include the major cold-shock proteins CspA and CspB in bacteria and the eukaryotic gene regulatory factor Y-box...; Region: CSP_CDS; cd04458
929506007815	DNA-binding site [nucleotide binding]; DNA binding site
929506007816	RNA-binding motif; other site
929506007817	Cytidylate kinase-like family; Region: Cytidylate_kin2; pfam13189
929506007818	Shikimate kinase (SK) is the fifth enzyme in the shikimate pathway, a seven-step biosynthetic pathway which converts erythrose-4-phosphate to chorismic acid, found in bacteria, fungi and plants. Chorismic acid is a important intermediate in the synthesis...; Region: SK; cd00464
929506007819	ADP binding site [chemical binding]; other site
929506007820	magnesium binding site [ion binding]; other site
929506007821	putative shikimate binding site; other site
929506007822	Shikimate 5-dehydrogenase [Amino acid transport and metabolism]; Region: AroE; COG0169
929506007823	Shikimate dehydrogenase substrate binding domain; Region: Shikimate_dh_N; pfam08501
929506007824	NAD(P) binding domain of Shikimate dehydrogenase; Region: NAD_bind_Shikimate_DH; cd01065
929506007825	shikimate binding site; other site
929506007826	NAD(P) binding site [chemical binding]; other site
929506007827	hypothetical protein; Provisional; Region: PRK07248
929506007828	Chorismate synthase [Amino acid transport and metabolism]; Region: AroC; COG0082
929506007829	Chorismase synthase, the enzyme catalyzing the final step of the shikimate pathway; Region: Chorismate_synthase; cd07304
929506007830	Tetramer interface [polypeptide binding]; other site
929506007831	active site
929506007832	FMN-binding site [chemical binding]; other site
929506007833	3-phosphoshikimate 1-carboxyvinyltransferase; Provisional; Region: PRK02427
929506007834	EPSP synthase domain. 3-phosphoshikimate 1-carboxyvinyltransferase (5-enolpyruvylshikimate-3-phosphate synthase) (EC 2.5.1.19) catalyses the reaction between shikimate-3-phosphate (S3P) and phosphoenolpyruvate (PEP) to form...; Region: EPSP_synthase; cd01556
929506007835	hinge; other site
929506007836	active site
929506007837	Dehydroquinate synthase (DHQS) catalyzes the conversion of DAHP to DHQ in shikimate pathway for aromatic compounds synthesis; Region: DHQS; cd08195
929506007838	active site
929506007839	dimer interface [polypeptide binding]; other site
929506007840	metal binding site [ion binding]; metal-binding site
929506007841	Prephenate dehydrogenase [Amino acid transport and metabolism]; Region: TyrA; COG0287
929506007842	prephenate dehydrogenase; Validated; Region: PRK08507
929506007843	3-deoxy-7-phosphoheptulonate synthase; Reviewed; Region: PRK08673
929506007844	phospho-2-dehydro-3-deoxyheptonate aldolase; Region: DAHP_synth_Bsub; TIGR01361
929506007845	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
929506007846	dimer interface [polypeptide binding]; other site
929506007847	conserved gate region; other site
929506007848	putative PBP binding loops; other site
929506007849	ABC-ATPase subunit interface; other site
929506007850	Periplasmic glycine betaine/choline-binding (lipo)protein of an ABC-type transport system (osmoprotectant binding protein) [Cell envelope biogenesis, outer membrane]; Region: OpuBC; COG1732
929506007851	ABC-type proline/glycine betaine transport systems, periplasmic components [Amino acid transport and metabolism]; Region: ProX; cl17891
929506007852	ABC-type proline/glycine betaine transport systems, ATPase components [Amino acid transport and metabolism]; Region: OpuBA; COG1125
929506007853	ATP-binding cassette domain of the osmoprotectant transporter; Region: ABC_OpuCA_Osmoprotection; cd03295
929506007854	Walker A/P-loop; other site
929506007855	ATP binding site [chemical binding]; other site
929506007856	Q-loop/lid; other site
929506007857	ABC transporter signature motif; other site
929506007858	Walker B; other site
929506007859	D-loop; other site
929506007860	H-loop/switch region; other site
929506007861	FOG: CBS domain [General function prediction only]; Region: COG0517
929506007862	This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains in association with the ABC transporter OpuCA. OpuCA is the ATP binding component of a bacterial solute transporter that serves a protective role to cells growing...; Region: CBS_pair_ABC_OpuCA_assoc2; cd04583
929506007863	Predicted acetyltransferases and hydrolases with the alpha/beta hydrolase fold [General function prediction only]; Region: LipA; COG1075
929506007864	Activator of 2-hydroxyglutaryl-CoA dehydratase (HSP70-class ATPase domain) [Lipid metabolism]; Region: COG1924
929506007865	BadF/BadG/BcrA/BcrD ATPase family; Region: BcrAD_BadFG; cl17271
929506007866	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3581
929506007867	CoA enzyme activase uncharacterized domain (DUF2229); Region: DUF2229; pfam09989
929506007868	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3581
929506007869	RT_G2_intron: Reverse transcriptases (RTs) with group II intron origin. RT transcribes DNA using RNA as template. Proteins in this subfamily are found in bacterial and mitochondrial group II introns. Their most probable ancestor was a retrotransposable...; Region: RT_G2_intron; cd01651
929506007870	Reverse transcriptase (RNA-dependent DNA polymerase); Region: RVT_1; pfam00078
929506007871	putative active site [active]
929506007872	putative NTP binding site [chemical binding]; other site
929506007873	putative nucleic acid binding site [nucleotide binding]; other site
929506007874	Group II intron, maturase-specific domain; Region: GIIM; pfam08388
929506007875	Permeases of the drug/metabolite transporter (DMT) superfamily [Carbohydrate transport and metabolism / Amino acid transport and metabolism / General function prediction only]; Region: RhaT; COG0697
929506007876	EamA-like transporter family; Region: EamA; cl17759
929506007877	EamA-like transporter family; Region: EamA; pfam00892
929506007878	4Fe-4S binding domain; Region: Fer4_5; pfam12801
929506007879	RPB11 and RPB3 subunits of RNA polymerase; Region: RNAP_RPB11_RPB3; cl11409
929506007880	4Fe-4S dicluster domain; Region: Fer4_9; pfam13187
929506007881	Protein of unknown function, DUF488; Region: DUF488; pfam04343
929506007882	AAA domain; Region: AAA_12; pfam13087
929506007883	AAA domain; Region: AAA_11; pfam13086
929506007884	Part of AAA domain; Region: AAA_19; pfam13245
929506007885	Superfamily I DNA and RNA helicases and helicase subunits [DNA replication, recombination, and repair]; Region: COG1112
929506007886	AAA domain; Region: AAA_12; pfam13087
929506007887	Transcriptional regulators [Transcription]; Region: PurR; COG1609
929506007888	Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392
929506007889	DNA binding site [nucleotide binding]
929506007890	domain linker motif; other site
929506007891	Ligand binding domain of the LacI tanscriptional regulator family belonging to the type I periplasmic-binding fold protein superfamily; Region: PBP1_LacI_sugar_binding_like; cd06267
929506007892	dimerization interface [polypeptide binding]; other site
929506007893	ligand binding site [chemical binding]; other site
929506007894	Predicted membrane protein [Function unknown]; Region: COG2323
929506007895	Isoleucyl-tRNA synthetase [Translation, ribosomal structure and biogenesis]; Region: IleS; COG0060
929506007896	catalytic core domain of isoleucyl-tRNA synthetases; Region: IleRS_core; cd00818
929506007897	HIGH motif; other site
929506007898	catalytic core domain of isoleucyl-tRNA synthetases; Region: IleRS_core; cd00818
929506007899	active site
929506007900	KMSKS motif; other site
929506007901	Anticodon-binding domain of archaeal, bacterial, and eukaryotic cytoplasmic isoleucyl tRNA synthetases; Region: Anticodon_Ia_Ile_ABEc; cd07961
929506007902	tRNA binding surface [nucleotide binding]; other site
929506007903	anticodon binding site; other site
929506007904	PemK-like protein; Region: PemK; pfam02452
929506007905	CAAX protease self-immunity; Region: Abi; pfam02517
929506007906	Bacterial Ig-like domain (group 4); Region: Big_4; pfam07532
929506007907	N-acetylmuramoyl-L-alanine amidase [Cell envelope biogenesis, outer membrane]; Region: AmiC; COG0860
929506007908	N-acetylmuramoyl-L-alanine amidase or MurNAc-LAA (also known as peptidoglycan aminohydrolase, NAMLA amidase, NAMLAA, Amidase 3, and peptidoglycan amidase; EC 3.5.1.28) is an autolysin that hydrolyzes the amide bond between N-acetylmuramoyl and L-amino...; Region: MurNAc-LAA; cd02696
929506007909	active site
929506007910	metal binding site [ion binding]; metal-binding site
929506007911	Bacterial Ig-like domain (group 4); Region: Big_4; pfam07532
929506007912	N-acetylmuramoyl-L-alanine amidase [Cell envelope biogenesis, outer membrane]; Region: AmiC; COG0860
929506007913	N-acetylmuramoyl-L-alanine amidase or MurNAc-LAA (also known as peptidoglycan aminohydrolase, NAMLA amidase, NAMLAA, Amidase 3, and peptidoglycan amidase; EC 3.5.1.28) is an autolysin that hydrolyzes the amide bond between N-acetylmuramoyl and L-amino...; Region: MurNAc-LAA; cd02696
929506007914	active site
929506007915	metal binding site [ion binding]; metal-binding site
929506007916	Predicted Zn-dependent hydrolases of the beta-lactamase fold [General function prediction only]; Region: COG2220
929506007917	Beta-lactamase superfamily domain; Region: Lactamase_B_3; pfam13483
929506007918	Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093
929506007919	non-specific DNA binding site [nucleotide binding]; other site
929506007920	salt bridge; other site
929506007921	sequence-specific DNA binding site [nucleotide binding]; other site
929506007922	Peptidase S24 LexA-like proteins are involved in the SOS response leading to the repair of single-stranded DNA within the bacterial cell. This family includes: the lambda repressor CI/C2 family and related bacterial prophage repressor proteins; LexA (EC...; Region: S24_LexA-like; cd06529
929506007923	Catalytic site [active]
929506007924	Domain of unknown function (DUF3783); Region: DUF3783; pfam12646
929506007925	cyclophilin: cyclophilin-type peptidylprolyl cis- trans isomerases. This family contains eukaryotic, bacterial and archeal proteins which exhibit a peptidylprolyl cis- trans isomerases activity (PPIase, Rotamase) and in addition bind the...; Region: cyclophilin; cd00317
929506007926	active site
929506007927	glutamate racemase; Provisional; Region: PRK00865
929506007928	Glutamine synthetase [Amino acid transport and metabolism]; Region: GlnA; COG0174
929506007929	Glutamine synthetase, catalytic domain; Region: Gln-synt_C; pfam00120
929506007930	Transposase domain (DUF772); Region: DUF772; pfam05598
929506007931	Transposase DDE domain; Region: DDE_Tnp_1_6; pfam13751
929506007932	FOG: CBS domain [General function prediction only]; Region: COG0517
929506007933	The CBS domain, named after human CBS, is a small domain originally identified in cystathionine beta-synthase and is subsequently found in a wide range of different proteins. CBS domains usually occur in tandem repeats. They associate to form a so-called...; Region: CBS_pair_30; cd04643
929506007934	pyruvate carboxylase; Reviewed; Region: PRK12999
929506007935	Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289
929506007936	Carbamoyl-phosphate synthase L chain, ATP binding domain; Region: CPSase_L_D2; pfam02786
929506007937	Biotin carboxylase C-terminal domain; Region: Biotin_carb_C; smart00878
929506007938	Pyruvate carboxylase and Transcarboxylase 5S, carboxyltransferase domain; Region: DRE_TIM_PC_TC_5S; cd07937
929506007939	active site
929506007940	catalytic residues [active]
929506007941	metal binding site [ion binding]; metal-binding site
929506007942	homodimer binding site [polypeptide binding]; other site
929506007943	The biotinyl-domain or biotin carboxyl carrier protein (BCCP) domain is present in all biotin-dependent enzymes, such as acetyl-CoA carboxylase, pyruvate carboxylase, propionyl-CoA carboxylase, methylcrotonyl-CoA carboxylase, geranyl-CoA carboxylase; Region: biotinyl_domain; cd06850
929506007944	carboxyltransferase (CT) interaction site; other site
929506007945	biotinylation site [posttranslational modification]; other site
929506007946	M20 Peptidase D has specificity for beta-alanyl-L-histidine dipeptide; Region: M20_pepD; cd03890
929506007947	Xaa-His dipeptidase; Region: aa-his-dipept; TIGR01893
929506007948	metal binding site [ion binding]; metal-binding site
929506007949	dimer interface [polypeptide binding]; other site
929506007950	Exopolysaccharide biosynthesis protein related to N-acetylglucosamine-1-phosphodiester alpha-N-acetylglucosaminidase [Carbohydrate transport and metabolism]; Region: EpsL; COG4632
929506007951	Uncharacterized proteins involved in stress response, homologs of TerZ and putative cAMP-binding protein CABP1 [Signal transduction mechanisms]; Region: TerZ; COG2310
929506007952	Uncharacterized proteins involved in stress response, similar to tellurium resistance terD; Region: TerD_like; cd06974
929506007953	putative metal binding site [ion binding]; other site
929506007954	Uncharacterized proteins involved in stress response, homologs of TerZ and putative cAMP-binding protein CABP1 [Signal transduction mechanisms]; Region: TerZ; COG2310
929506007955	Uncharacterized proteins involved in stress response, similar to tellurium resistance terD; Region: TerD_like; cd06974
929506007956	putative metal binding site [ion binding]; other site
929506007957	Uncharacterized proteins involved in stress response, homologs of TerZ and putative cAMP-binding protein CABP1 [Signal transduction mechanisms]; Region: TerZ; COG2310
929506007958	Uncharacterized proteins involved in stress response, similar to tellurium resistance terD; Region: TerD_like; cd06974
929506007959	putative metal binding site [ion binding]; other site
929506007960	Predicted transcriptional regulator [Transcription]; Region: COG1959
929506007961	Transcriptional regulator; Region: Rrf2; pfam02082
929506007962	carbon-monoxide dehydrogenase, catalytic subunit; Region: CO_DH_cata; TIGR01702
929506007963	The HCP family of iron-sulfur proteins includes hybrid cluster protein (HCP), acetyl-CoA synthase (ACS), and carbon monoxide dehydrogenase (CODH), all of which contain [Fe4-S4] metal clusters at their active sites. These proteins have a conserved...; Region: HCP_like; cl14655
929506007964	ACS interaction site; other site
929506007965	CODH interaction site; other site
929506007966	metal cluster binding site [ion binding]; other site
929506007967	Xanthine/uracil/vitamin C permease [Nucleotide transport and    metabolism]; Region: COG2252
929506007968	Uncharacterized proteins involved in stress response, homologs of TerZ and putative cAMP-binding protein CABP1 [Signal transduction mechanisms]; Region: TerZ; COG2310
929506007969	Uncharacterized proteins involved in stress response, similar to tellurium resistance terD; Region: TerD_like; cd06974
929506007970	putative metal binding site [ion binding]; other site
929506007971	Mitochondrial biogenesis AIM24; Region: AIM24; pfam01987
929506007972	Domain of unknown function (DUF4356); Region: DUF4356; pfam14266
929506007973	Domain of unknown function (DUF4356); Region: DUF4356; pfam14266
929506007974	Toxic anion resistance protein (TelA); Region: TelA; pfam05816
929506007975	Protein of unknown function (DUF3888); Region: DUF3888; pfam13027
929506007976	Uncharacterized membrane protein [Function unknown]; Region: SapB; COG1285
929506007977	MgtC family; Region: MgtC; pfam02308
929506007978	ATPases involved in chromosome partitioning [Cell division and chromosome partitioning]; Region: Mrp; COG0489
929506007979	MRP (Multiple Resistance and pH adaptation) is a homologue of the Fer4_NifH superfamily. Like the other members of the superfamily, MRP contains a ATP-binding domain at the N-termini. It is found in bacteria as a membrane-spanning protein and functions...; Region: MRP-like; cd02037
929506007980	16S ribosomal RNA methyltransferase KsgA/Dim1 family protein; Reviewed; Region: ksgA; PRK00274
929506007981	Dimethyladenosine transferase (rRNA methylation) [Translation, ribosomal structure and biogenesis]; Region: KsgA; COG0030
929506007982	ribonuclease M5; Region: 5S_RNA_mat_M5; TIGR00334
929506007983	TOPRIM_ RNase M5_like: The topoisomerase-primase (TOPRIM) nucleotidyl transferase/hydrolase domain found in Ribonuclease M5: (RNase M5) and other small primase-like proteins from bacteria and archaea.  RNase M5 catalyzes the maturation of 5S rRNA in low...; Region: TOPRIM_RNase_M5_like; cd01027
929506007984	putative active site [active]
929506007985	putative metal binding site [ion binding]; other site
929506007986	Domain of unknown function (DUF4093); Region: DUF4093; pfam13331
929506007987	Domain of unknown function (DUF348); Region: DUF348; pfam03990
929506007988	Domain of unknown function (DUF348); Region: DUF348; pfam03990
929506007989	G5 domain; Region: G5; pfam07501
929506007990	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3584
929506007991	TatD like proteins;  E.coli TatD is a cytoplasmic protein, shown to have magnesium dependent DNase activity; Region: TatD_DNAse; cd01310
929506007992	active site
929506007993	Transglutaminase-like superfamily; Region: Transglut_core; pfam01841
929506007994	phosphotransferase mannnose-specific family component IIA; Provisional; Region: PRK14484
929506007995	active pocket/dimerization site; other site
929506007996	active site
929506007997	phosphorylation site [posttranslational modification]
929506007998	dihydroxyacetone kinase, phosphoprotein-dependent, L subunit; Region: dha_L_ycgS; TIGR02365
929506007999	dihydroxyacetone kinase subunit DhaK; Provisional; Region: PRK14481
929506008000	Dihydroxyacetone kinase [Carbohydrate transport and metabolism]; Region: DAK1; COG2376
929506008001	Protein of unknown function (DUF445); Region: DUF445; pfam04286
929506008002	Domain of unknown function (DUF4163); Region: DUF4163; pfam13739
929506008003	Protein of unknown function (DUF3298); Region: DUF3298; pfam11738
929506008004	methionyl-tRNA synthetase; Reviewed; Region: PRK12267
929506008005	catalytic core domain of methioninyl-tRNA synthetases; Region: MetRS_core; cd00814
929506008006	active site
929506008007	HIGH motif; other site
929506008008	KMSKS motif; other site
929506008009	Anticodon-binding domain of methionyl tRNA synthetases; Region: Anticodon_Ia_Met; cd07957
929506008010	tRNA binding surface [nucleotide binding]; other site
929506008011	anticodon binding site; other site
929506008012	tRNA-binding-domain-containing Escherichia coli methionyl-tRNA synthetase (EcMetRS)-like proteins.  This family includes EcMetRS and Aquifex aeolicus Trbp111 (AaTrbp111). This domain has general tRNA binding properties.  MetRS aminoacylates methionine...; Region: tRNA_bind_EcMetRS_like; cd02800
929506008013	dimer interface [polypeptide binding]; other site
929506008014	putative tRNA-binding site [nucleotide binding]; other site
929506008015	Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745
929506008016	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
929506008017	active site
929506008018	phosphorylation site [posttranslational modification]
929506008019	intermolecular recognition site; other site
929506008020	dimerization interface [polypeptide binding]; other site
929506008021	Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383
929506008022	DNA binding site [nucleotide binding]
929506008023	Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642
929506008024	Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225
929506008025	dimerization interface [polypeptide binding]; other site
929506008026	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
929506008027	dimer interface [polypeptide binding]; other site
929506008028	phosphorylation site [posttranslational modification]
929506008029	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
929506008030	ATP binding site [chemical binding]; other site
929506008031	Mg2+ binding site [ion binding]; other site
929506008032	G-X-G motif; other site
929506008033	Predicted xylanase/chitin deacetylase [Carbohydrate transport and metabolism]; Region: CDA1; COG0726
929506008034	Catalytic NodB homology domain of Streptococcus mutans polysaccharide deacetylase PgdA, Bacillus subtilis YheN, and similar proteins; Region: CE4_SmPgdA_like; cd10944
929506008035	NodB motif; other site
929506008036	active site
929506008037	catalytic site [active]
929506008038	Zn binding site [ion binding]; other site
929506008039	Family 4 Uracil-DNA glycosylase (UDG), found exclusively in thermophilic organisms; Region: UDG_F4_TTUDGA_like; cd10030
929506008040	Fe-S cluster binding site [ion binding]; other site
929506008041	active site
929506008042	Subfamily of the multidrug and toxic compound extrusion (MATE)-like proteins similar to Thermotoga marina NorM; Region: MATE_NorM_like; cd13137
929506008043	putative efflux protein, MATE family; Region: matE; TIGR00797
929506008044	homoserine kinase; Provisional; Region: PRK01212
929506008045	GHMP kinases N terminal domain; Region: GHMP_kinases_N; pfam00288
929506008046	Uncharacterized membrane protein [Function unknown]; Region: SpmB; COG0700
929506008047	Uncharacterized membrane protein, required for spore maturation in B.subtilis. [General function prediction only]; Region: SpmA; COG2715
929506008048	lumazine synthase (6,7-dimethyl-8-ribityllumazine synthase, LS), catalyzes the penultimate step in the biosynthesis of riboflavin (vitamin B2); type-I; Region: Lumazine_synthase-I; cd09209
929506008049	homopentamer interface [polypeptide binding]; other site
929506008050	active site
929506008051	bifunctional 3,4-dihydroxy-2-butanone 4-phosphate synthase/GTP cyclohydrolase II protein; Provisional; Region: PRK09311
929506008052	3,4-dihydroxy-2-butanone 4-phosphate synthase; Region: DHBP_synthase; pfam00926
929506008053	GTP cyclohydrolase II (RibA).  GTP cyclohydrolase II catalyzes the conversion of GTP to 2,5-diamino-6-ribosylamino-4(3H)-pyrimidinone 5' phosphate, formate, pyrophosphate (APy), and GMP in the biosynthetic pathway of riboflavin. Riboflavin is the...; Region: GTP_cyclohydro2; cd00641
929506008054	dimerization interface [polypeptide binding]; other site
929506008055	active site
929506008056	riboflavin synthase subunit alpha; Provisional; Region: PRK09289
929506008057	Lumazine binding domain; Region: Lum_binding; pfam00677
929506008058	Lumazine binding domain; Region: Lum_binding; pfam00677
929506008059	riboflavin biosynthesis protein RibD; Region: eubact_ribD; TIGR00326
929506008060	Riboflavin-specific deaminase. Riboflavin biosynthesis protein RibD (Diaminohydroxyphosphoribosylaminopyrimidine deaminase) catalyzes the deamination of 2,5-diamino-6-ribosylamino-4(3H)-pyrimidinone 5'-phosphate, which is an intermediate step in the...; Region: Riboflavin_deaminase-reductase; cd01284
929506008061	catalytic motif [active]
929506008062	Zn binding site [ion binding]; other site
929506008063	5-amino-6-(5-phosphoribosylamino)uracil reductase; Validated; Region: PRK05625
929506008064	peptidase T; Region: peptidase-T; TIGR01882
929506008065	M20 Peptidase T specifically cleaves tripeptides; Region: M20_peptT; cd03892
929506008066	metal binding site [ion binding]; metal-binding site
929506008067	dimer interface [polypeptide binding]; other site
929506008068	phosphate regulon sensor kinase PhoR; Region: phoR_proteo; TIGR02966
929506008069	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
929506008070	dimer interface [polypeptide binding]; other site
929506008071	phosphorylation site [posttranslational modification]
929506008072	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
929506008073	ATP binding site [chemical binding]; other site
929506008074	Mg2+ binding site [ion binding]; other site
929506008075	G-X-G motif; other site
929506008076	Heptaprenyl diphosphate synthase component I; Region: Hpre_diP_synt_I; pfam07456
929506008077	Listerrria innocua Lin0431  is similar to the N-Utilization Substance G (NusG) N terminal (NGN) insert (DII); Region: Lin0431_like; cd09911
929506008078	trimer interface [polypeptide binding]; other site
929506008079	Membrane-associated lipoprotein involved in thiamine biosynthesis [Coenzyme metabolism]; Region: ApbE; COG1477
929506008080	ApbE family; Region: ApbE; pfam02424
929506008081	glucose-1-phosphate adenylyltransferase; Provisional; Region: glgC; PRK05293
929506008082	ADP-glucose pyrophosphorylase is involved in the biosynthesis of glycogen or starch; Region: ADP_Glucose_PP; cd02508
929506008083	ligand binding site; other site
929506008084	oligomer interface; other site
929506008085	Glucose-1-phosphate adenylyltransferase, C-terminal Left-handed parallel beta helix (LbH) domain: Glucose-1-phosphate adenylyltransferase is also known as ADP-glucose synthase or ADP-glucose pyrophosphorylase. It catalyzes the first committed and...; Region: LbH_G1P_AT_C; cd04651
929506008086	dimer interface [polypeptide binding]; other site
929506008087	N-terminal domain interface [polypeptide binding]; other site
929506008088	sulfate 1 binding site; other site
929506008089	glucose-1-phosphate adenylyltransferase, GlgD subunit; Region: glgD; TIGR02092
929506008090	ADP-glucose pyrophosphorylase is involved in the biosynthesis of glycogen or starch; Region: ADP_Glucose_PP; cd02508
929506008091	ligand binding site; other site
929506008092	oligomer interface; other site
929506008093	Glucose-1-phosphate adenylyltransferase, C-terminal Left-handed parallel beta helix (LbH) domain: Glucose-1-phosphate adenylyltransferase is also known as ADP-glucose synthase or ADP-glucose pyrophosphorylase. It catalyzes the first committed and...; Region: LbH_G1P_AT_C; cd04651
929506008094	dimer interface [polypeptide binding]; other site
929506008095	N-terminal domain interface [polypeptide binding]; other site
929506008096	sulfate 1 binding site; other site
929506008097	Beta- N-acetylglucosaminidase [Carbohydrate transport and metabolism]; Region: LytD; COG4193
929506008098	Mannosyl-glycoprotein endo-beta-N-acetylglucosaminidase; Region: Glucosaminidase; cl17361
929506008099	AP endonuclease family 2; These endonucleases play a role in DNA repair. Cleave phosphodiester bonds at apurinic or apyrimidinic sites; the alignment also contains hexulose-6-phosphate isomerases, enzymes that catalyze the epimerization of...; Region: AP2Ec; cl12060
929506008100	AP (apurinic/apyrimidinic) site pocket; other site
929506008101	Xylose isomerase-like TIM barrel; Region: AP_endonuc_2; pfam01261
929506008102	DNA interaction; other site
929506008103	Metal-binding active site; metal-binding site
929506008104	D-3-phosphoglycerate dehydrogenase; Provisional; Region: PRK13581
929506008105	Phosphoglycerate dehydrogenases, NAD-binding and catalytic domains; Region: PGDH_4; cd12173
929506008106	ligand binding site [chemical binding]; other site
929506008107	NAD binding site [chemical binding]; other site
929506008108	dimerization interface [polypeptide binding]; other site
929506008109	catalytic site [active]
929506008110	C-terminal ACT (regulatory) domain of D-3-phosphoglycerate dehydrogenase (3PGDH); Region: ACT_3PGDH-xct; cd04902
929506008111	putative L-serine binding site [chemical binding]; other site
929506008112	Alanine-glyoxylate aminotransferase (AGAT) family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to alanine-glyoxylate aminotransferase (AGAT); Region: AGAT_like; cd06451
929506008113	homodimer interface [polypeptide binding]; other site
929506008114	pyridoxal 5'-phosphate binding site [chemical binding]; other site
929506008115	catalytic residue [active]
929506008116	Na+-driven multidrug efflux pump [Defense mechanisms]; Region: NorM; COG0534
929506008117	Subfamily of the multidrug and toxic compound extrusion (MATE)-like proteins similar to Thermotoga marina NorM; Region: MATE_NorM_like; cd13137
929506008118	MECDP_synthase (2-C-methyl-D-erythritol-2,4-cyclodiphosphate synthase), encoded by the ispF gene, catalyzes the formation of 2-C-methyl-D-erythritol 2,4-cyclodiphosphate (MEC) in the non-mevalonate deoxyxylulose (DOXP) pathway for isoprenoid biosynthesis; Region: MECDP_synthase; cd00554
929506008119	homotrimer interaction site [polypeptide binding]; other site
929506008120	zinc binding site [ion binding]; other site
929506008121	CDP-binding sites; other site
929506008122	Predicted transcriptional regulators [Transcription]; Region: COG1733
929506008123	Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090
929506008124	putative DNA binding site [nucleotide binding]; other site
929506008125	putative Zn2+ binding site [ion binding]; other site
929506008126	plasmid segregation protein ParM; Provisional; Region: PRK13917
929506008127	Plasmid segregation protein ParM and similar proteins; Region: ParM_like; cd10227
929506008128	Mg binding site [ion binding]; other site
929506008129	nucleotide binding site [chemical binding]; other site
929506008130	putative protofilament interface [polypeptide binding]; other site
929506008131	Na+/alanine symporter [Amino acid transport and metabolism]; Region: AlsT; COG1115
929506008132	amino acid carrier protein; Region: agcS; TIGR00835
929506008133	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3677
929506008134	InsA N-terminal domain; Region: Zn_Tnp_IS1; pfam03811
929506008135	Integrase core domain; Region: rve; pfam00665
929506008136	Predicted membrane protein [Function unknown]; Region: COG1297
929506008137	putative oligopeptide transporter, OPT family; Region: TIGR00733
929506008138	ornithine carbamoyltransferase; Validated; Region: PRK02102
929506008139	Aspartate/ornithine carbamoyltransferase, carbamoyl-P binding domain; Region: OTCace_N; pfam02729
929506008140	Aspartate/ornithine carbamoyltransferase, Asp/Orn binding domain; Region: OTCace; pfam00185
929506008141	Domain of unknown function (DUF1836); Region: DUF1836; pfam08876
929506008142	Transaldolase-like fructose-6-phosphate aldolases (FSA) found in bacteria and archaea; Region: Transaldolase_FSA; cd00956
929506008143	active site
929506008144	intersubunit interactions; other site
929506008145	catalytic residue [active]
929506008146	RelA- and SpoT-like ppGpp Synthetases and Hydrolases, catalytic domain; Region: Rel-Spo_like; cl11966
929506008147	tRNA nucleotidyltransferase/poly(A) polymerase [Translation, ribosomal structure and biogenesis]; Region: PcnB; COG0617
929506008148	metal binding triad [ion binding]; metal-binding site
929506008149	Probable RNA and SrmB- binding site of polymerase A; Region: PolyA_pol_RNAbd; pfam12627
929506008150	Regulators of stationary/sporulation gene expression [Transcription]; Region: AbrB; COG2002
929506008151	SpoVT / AbrB like domain; Region: SpoVT_AbrB; smart00966
929506008152	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3883
929506008153	Cell wall-associated hydrolases (invasion-associated proteins) [Cell envelope biogenesis, outer membrane]; Region: Spr; COG0791
929506008154	NlpC/P60 family; Region: NLPC_P60; pfam00877
929506008155	Predicted methyltransferases [General function prediction only]; Region: COG0313
929506008156	Ribosomal RNA small subunit methyltransferase I, also known as rRNA (cytidine-2'-O-)-methyltransferase RsmI; Region: RsmI; cd11648
929506008157	putative SAM binding site [chemical binding]; other site
929506008158	putative homodimer interface [polypeptide binding]; other site
929506008159	Predicted O-methyltransferase [General function prediction only]; Region: COG4123
929506008160	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
929506008161	S-adenosylmethionine binding site [chemical binding]; other site
929506008162	LrgA family; Region: LrgA; pfam03788
929506008163	Putative effector of murein hydrolase [Cell envelope biogenesis, outer membrane]; Region: LrgB; COG1346
929506008164	The HCP family of iron-sulfur proteins includes hybrid cluster protein (HCP), acetyl-CoA synthase (ACS), and carbon monoxide dehydrogenase (CODH), all of which contain [Fe4-S4] metal clusters at their active sites. These proteins have a conserved...; Region: HCP_like; cl14655
929506008165	4Fe-4S dicluster domain; Region: Fer4_7; pfam12838
929506008166	Heavy-metal-associated domain (HMA) is a conserved domain of approximately 30 amino acid residues found in a number of proteins that transport or detoxify heavy metals, for example, the CPx-type heavy metal ATPases and copper chaperones. HMA domain...; Region: HMA; cl00207
929506008167	metal-binding site [ion binding]
929506008168	Uncharacterized homolog of PSP1 [Function unknown]; Region: COG1774
929506008169	DNA polymerase III subunit delta'; Validated; Region: PRK05564
929506008170	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
929506008171	Walker A motif; other site
929506008172	ATP binding site [chemical binding]; other site
929506008173	Walker B motif; other site
929506008174	arginine finger; other site
929506008175	Protein of unknown function (DUF970); Region: DUF970; pfam06153
929506008176	thymidylate kinase; Validated; Region: tmk; PRK00698
929506008177	Thymidine monophosphate kinase (TMPK), also known as thymidylate kinase, catalyzes the phosphorylation of thymidine monophosphate (TMP) to thymidine diphosphate (TDP) utilizing ATP as its preferred phophoryl donor. TMPK represents the rate-limiting step...; Region: TMPK; cd01672
929506008178	TMP-binding site; other site
929506008179	ATP-binding site [chemical binding]; other site
929506008180	Arginine/lysine/ornithine decarboxylases [Amino acid transport and metabolism]; Region: LdcC; COG1982
929506008181	Ornithine decarboxylase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD corresponds to ornithine decarboxylase (ODC), arginine decarboxylase (ADC) and lysine...; Region: Orn_deC_like; cd00615
929506008182	homodimer interface [polypeptide binding]; other site
929506008183	pyridoxal 5'-phosphate binding site [chemical binding]; other site
929506008184	catalytic residue [active]
929506008185	Orn/Lys/Arg decarboxylase, C-terminal domain; Region: OKR_DC_1_C; pfam03711
929506008186	Inhibitor of sigma-G Gin; Region: Gin; pfam10764
929506008187	Sporulation lipoprotein YhcN/YlaJ (Spore_YhcN_YlaJ); Region: Spore_YhcN_YlaJ; pfam09580
929506008188	L,D-transpeptidase catalytic domain; Region: YkuD; pfam03734
929506008189	Uncharacterized protein conserved in bacteria [Function unknown]; Region: ErfK; COG1376
929506008190	Metal-dependent amidase/aminoacylase/carboxypeptidase [General function prediction only]; Region: AbgB; COG1473
929506008191	Zinc peptidases M18, M20, M28, and M42; Region: Zinc_peptidase_like; cl14876
929506008192	metal binding site [ion binding]; metal-binding site
929506008193	Mg2+ and Co2+ transporters [Inorganic ion transport and metabolism]; Region: CorA; COG0598
929506008194	uncharacterized bacterial subfamily of the Escherichia coli CorA-Salmonella typhimurium ZntB family; Region: EcCorA_ZntB-like_u2; cd12827
929506008195	Cl binding site [ion binding]; other site
929506008196	oligomer interface [polypeptide binding]; other site
929506008197	LD-Carboxypeptidase, a serine protease, includes microcin C7 self immunity protein; Region: Peptidase_S66; cd07025
929506008198	dimer interface [polypeptide binding]; other site
929506008199	catalytic triad [active]
929506008200	solute carrier 6 subfamily, Fusobacterium nucleatum Tyt1-like; solute-binding domain; Region: SLC6sbd_Tyt1-Like; cd10336
929506008201	Na2 binding site [ion binding]; other site
929506008202	putative substrate binding site 1 [chemical binding]; other site
929506008203	Na binding site 1 [ion binding]; other site
929506008204	putative substrate binding site 2 [chemical binding]; other site
929506008205	NAD-dependent deacetylase; Provisional; Region: PRK00481
929506008206	SIR2 superfamily of proteins includes silent information regulator 2 (Sir2) enzymes which catalyze NAD+-dependent protein/histone deacetylation, where the acetyl group from the lysine epsilon-amino group is transferred to the ADP-ribose moiety of NAD+; Region: SIR2; cl00195
929506008207	Family description; Region: VCBS; pfam13517
929506008208	peptidylprolyl isomerase; Provisional; Region: prsA; PRK00059
929506008209	PPIC-type PPIASE domain; Region: Rotamase; pfam00639
929506008210	CAAX protease self-immunity; Region: Abi; pfam02517
929506008211	ABC-type Mn/Zn transport systems, ATPase component [Inorganic ion transport and metabolism]; Region: ZnuC; COG1121
929506008212	ATP-binding cassette domain of the drug resistance transporter and related proteins, subfamily A; Region: ABC_DR_subfamily_A; cd03230
929506008213	Walker A/P-loop; other site
929506008214	ATP binding site [chemical binding]; other site
929506008215	Q-loop/lid; other site
929506008216	ABC transporter signature motif; other site
929506008217	Walker B; other site
929506008218	D-loop; other site
929506008219	H-loop/switch region; other site
929506008220	Predicted transcriptional regulators [Transcription]; Region: COG1725
929506008221	Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377
929506008222	DNA-binding site [nucleotide binding]; DNA binding site
929506008223	PaaI_thioesterase is a tetrameric acyl-CoA thioesterase with a hot dog fold and one of several proteins responsible for phenylacetic acid (PA) degradation in bacteria.  Although orthologs of PaaI exist in archaea and eukaryotes, their function has not...; Region: PaaI_thioesterase; cd03443
929506008224	CoenzymeA binding site [chemical binding]; other site
929506008225	subunit interaction site [polypeptide binding]; other site
929506008226	PHB binding site; other site
929506008227	Serine-pyruvate aminotransferase/archaeal aspartate aminotransferase [Amino acid transport and metabolism]; Region: COG0075
929506008228	pyridoxal 5'-phosphate binding pocket [chemical binding]; other site
929506008229	catalytic residue [active]
929506008230	Family 4 Uracil-DNA glycosylase (UDG), found exclusively in thermophilic organisms; Region: UDG_F4_TTUDGA_like; cd10030
929506008231	active site
929506008232	Fe-S cluster binding site [ion binding]; other site
929506008233	Cellulase M and related proteins [Carbohydrate transport and metabolism]; Region: FrvX; COG1363
929506008234	Zinc peptidases M18, M20, M28, and M42; Region: Zinc_peptidase_like; cl14876
929506008235	metal binding site [ion binding]; metal-binding site
929506008236	Cellulase M and related proteins [Carbohydrate transport and metabolism]; Region: FrvX; COG1363
929506008237	M42 Peptidase, Endoglucanases; Region: M42_Frv; cd05656
929506008238	oligomer interface [polypeptide binding]; other site
929506008239	active site
929506008240	metal binding site [ion binding]; metal-binding site
929506008241	Cellulase M and related proteins [Carbohydrate transport and metabolism]; Region: FrvX; COG1363
929506008242	M42 Peptidase, Endoglucanases; Region: M42_Frv; cd05656
929506008243	oligomer interface [polypeptide binding]; other site
929506008244	active site
929506008245	metal binding site [ion binding]; metal-binding site
929506008246	N-acetylmuramoyl-L-alanine amidase [Cell envelope biogenesis, outer membrane]; Region: AmiC; COG0860
929506008247	N-acetylmuramoyl-L-alanine amidase or MurNAc-LAA (also known as peptidoglycan aminohydrolase, NAMLA amidase, NAMLAA, Amidase 3, and peptidoglycan amidase; EC 3.5.1.28) is an autolysin that hydrolyzes the amide bond between N-acetylmuramoyl and L-amino...; Region: MurNAc-LAA; cd02696
929506008248	active site
929506008249	metal binding site [ion binding]; metal-binding site
929506008250	Small-conductance mechanosensitive channel [Cell envelope biogenesis, outer membrane]; Region: MscS; COG0668
929506008251	Mechanosensitive ion channel; Region: MS_channel; pfam00924
929506008252	Acetyltransferases, including N-acetylases of ribosomal proteins [Translation, ribosomal structure and biogenesis]; Region: RimL; COG1670
929506008253	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl17182
929506008254	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
929506008255	putative substrate translocation pore; other site
929506008256	Dinucleotide-utilizing enzymes involved in molybdopterin and thiamine biosynthesis family 1 [Coenzyme metabolism]; Region: COG1179
929506008257	Family of activating enzymes (E1) of ubiquitin-like proteins related to the E.coli hypothetical protein ygdL. The common reaction mechanism catalyzed by E1-like enzymes begins with a nucleophilic attack of the C-terminal carboxylate of the ubiquitin-like...; Region: YgdL_like; cd00755
929506008258	putative ATP binding site [chemical binding]; other site
929506008259	putative substrate interface [chemical binding]; other site
929506008260	NADH pyrophosphatase, a member of the Nudix hydrolase superfamily, catalyzes the cleavage of NADH into reduced nicotinamide mononucleotide (NMNH) and AMP. Like other members of the Nudix family, it requires a divalent cation, such as Mg2+ or Mn2+, for...; Region: NADH_pyrophosphatase; cd03429
929506008261	putative NADH binding site [chemical binding]; other site
929506008262	putative active site [active]
929506008263	nudix motif; other site
929506008264	putative metal binding site [ion binding]; other site
929506008265	putative DNA-binding transcriptional regulator; Reviewed; Region: PRK00347
929506008266	recombination protein RecR; Reviewed; Region: recR; PRK00076
929506008267	RecR protein; Region: RecR; pfam02132
929506008268	TOPRIM_recR: topoisomerase-primase (TOPRIM) nucleotidyl transferase/hydrolase domain of the type found in Escherichia coli RecR.  RecR participates in the RecFOR pathway of homologous recombinational repair in prokaryotes. This pathway provides a...; Region: TOPRIM_recR; cd01025
929506008269	putative active site [active]
929506008270	putative metal-binding site [ion binding]; other site
929506008271	tetramer interface [polypeptide binding]; other site
929506008272	hypothetical protein; Validated; Region: PRK00153
929506008273	DNA polymerase III subunits gamma and tau; Validated; Region: PRK05563
929506008274	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
929506008275	Walker A motif; other site
929506008276	ATP binding site [chemical binding]; other site
929506008277	Walker B motif; other site
929506008278	arginine finger; other site
929506008279	DNA polymerase III subunits gamma and tau domain III; Region: DNA_pol3_gamma3; pfam12169
929506008280	Nucleoside deaminases include adenosine, guanine and cytosine deaminases. These enzymes are Zn dependent and catalyze the deamination of nucleosides. The zinc ion in the active site plays a central role in the proposed catalytic mechanism, activating a...; Region: nucleoside_deaminase; cd01285
929506008281	nucleoside/Zn binding site; other site
929506008282	dimer interface [polypeptide binding]; other site
929506008283	catalytic motif [active]
929506008284	Integral membrane protein (intg_mem_TP0381); Region: Intg_mem_TP0381; pfam09529
929506008285	Phosphatidylserine decarboxylase; Region: PS_Dcarbxylase; cl03656
929506008286	Metal-dependent hydrolases of the beta-lactamase superfamily III [General function prediction only]; Region: ElaC; COG1234
929506008287	Membrane domain of glycerophosphoryl diester phosphodiesterase; Region: GPDPase_memb; cl01974
929506008288	Glycerophosphoryl diester phosphodiesterase [Energy production and conversion]; Region: UgpQ; COG0584
929506008289	Glycerophosphodiester phosphodiesterase domain of uncharacterized bacterial glycerophosphodiester phosphodiesterases; Region: GDPD_memb_like; cd08579
929506008290	putative active site [active]
929506008291	catalytic site [active]
929506008292	putative metal binding site [ion binding]; other site
929506008293	seryl-tRNA synthetase; Provisional; Region: PRK05431
929506008294	Seryl-tRNA synthetase N-terminal domain; Region: Seryl_tRNA_N; pfam02403
929506008295	Seryl-tRNA synthetase (SerRS) class II core catalytic domain. SerRS is responsible for the attachment of serine to the 3' OH group of ribose of the appropriate tRNA. This domain It is primarily responsible for ATP-dependent formation of the enzyme...; Region: SerRS_core; cd00770
929506008296	dimer interface [polypeptide binding]; other site
929506008297	active site
929506008298	motif 1; other site
929506008299	motif 2; other site
929506008300	motif 3; other site
929506008301	Protein of unknown function (DUF1667); Region: DUF1667; pfam07892
929506008302	Predicted dehydrogenase [General function prediction only]; Region: COG0579
929506008303	hydroxyglutarate oxidase; Provisional; Region: PRK11728
929506008304	BFD-like [2Fe-2S] binding domain; Region: Fer2_BFD; pfam04324
929506008305	Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642
929506008306	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
929506008307	dimer interface [polypeptide binding]; other site
929506008308	phosphorylation site [posttranslational modification]
929506008309	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
929506008310	ATP binding site [chemical binding]; other site
929506008311	Mg2+ binding site [ion binding]; other site
929506008312	G-X-G motif; other site
929506008313	Response regulator receiver domain; Region: Response_reg; pfam00072
929506008314	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
929506008315	active site
929506008316	phosphorylation site [posttranslational modification]
929506008317	intermolecular recognition site; other site
929506008318	hypothetical protein; Validated; Region: PRK00068
929506008319	Uncharacterized conserved protein [Function unknown]; Region: COG1615
929506008320	Predicted small molecule binding protein (contains 3H domain) [General function prediction only]; Region: COG1827
929506008321	HTH domain; Region: HTH_11; pfam08279
929506008322	3H domain; Region: 3H; pfam02829
929506008323	Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cl17215
929506008324	DNA gyrase subunit A; Validated; Region: PRK05560
929506008325	DNA Topoisomerase, subtype IIA; domain A'; bacterial DNA topoisomerase IV (C subunit, ParC), bacterial DNA gyrases (A subunit, GyrA),mammalian DNA toposiomerases II. DNA topoisomerases are essential enzymes that regulate the conformational changes...; Region: TOP4c; cd00187
929506008326	CAP-like domain; other site
929506008327	active site
929506008328	primary dimer interface [polypeptide binding]; other site
929506008329	DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989
929506008330	DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989
929506008331	DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989
929506008332	DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989
929506008333	DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989
929506008334	DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989
929506008335	DNA gyrase subunit B; Validated; Region: gyrB; PRK05644
929506008336	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
929506008337	Mg2+ binding site [ion binding]; other site
929506008338	G-X-G motif; other site
929506008339	TopoIIA_Trans_DNA_gyrase: Transducer domain, having a ribosomal S5 domain 2-like fold, of the type found in proteins of the type IIA family of DNA topoisomerases similar to the B subunits of E. coli DNA gyrase and E. coli Topoisomerase IV which are; Region: TopoII_Trans_DNA_gyrase; cd00822
929506008340	anchoring element; other site
929506008341	dimer interface [polypeptide binding]; other site
929506008342	ATP binding site [chemical binding]; other site
929506008343	TOPRIM_TopoIIA_GyrB: topoisomerase-primase (TOPRIM) nucleotidyl transferase/hydrolase domain of the type found in proteins of the type IIA family of DNA topoisomerases similar to the Escherichia coli GyrB subunit. TopoIIA enzymes cut both strands of the...; Region: TOPRIM_TopoIIA_GyrB; cd03366
929506008344	active site
929506008345	putative metal-binding site [ion binding]; other site
929506008346	DNA gyrase B subunit, carboxyl terminus; Region: DNA_gyraseB_C; pfam00986
929506008347	Glycosyl transferase family 41; Region: Glyco_transf_41; pfam13844
929506008348	recombination protein F; Reviewed; Region: recF; PRK00064
929506008349	ATP-binding cassette domain of RecF; Region: ABC_RecF; cd03242
929506008350	Walker A/P-loop; other site
929506008351	ATP binding site [chemical binding]; other site
929506008352	Q-loop/lid; other site
929506008353	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
929506008354	ABC transporter signature motif; other site
929506008355	Walker B; other site
929506008356	D-loop; other site
929506008357	H-loop/switch region; other site
929506008358	S4 domain; Region: S4_2; pfam13275
929506008359	DNA polymerase III subunit beta; Validated; Region: PRK05643
929506008360	Beta clamp domain.  The beta subunit (processivity factor) of DNA polymerase III holoenzyme, refered to as the beta clamp, forms a ring shaped dimer that encircles dsDNA (sliding clamp) in bacteria.  The beta-clamp is structurally similar to the trimeric...; Region: beta_clamp; cd00140
929506008361	putative DNA binding surface [nucleotide binding]; other site
929506008362	dimer interface [polypeptide binding]; other site
929506008363	beta-clamp/clamp loader binding surface; other site
929506008364	beta-clamp/translesion DNA polymerase binding surface; other site
929506008365	chromosomal replication initiation protein; Reviewed; Region: dnaA; PRK00149
929506008366	DnaA N-terminal domain; Region: DnaA_N; pfam11638
929506008367	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
929506008368	Walker A motif; other site
929506008369	ATP binding site [chemical binding]; other site
929506008370	Walker B motif; other site
929506008371	arginine finger; other site
929506008372	C-terminal domain of bacterial DnaA proteins. The DNA-binding C-terminal domain of DnaA contains a helix-turn-helix motif that specifically interacts with the DnaA box, a 9-mer motif that occurs repetitively in the replication origin oriC. Multiple...; Region: Bac_DnaA_C; cd06571
929506008373	DnaA box-binding interface [nucleotide binding]; other site
929506008374	Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cl17220
929506008375	putative DNA binding site [nucleotide binding]; other site
929506008376	putative Zn2+ binding site [ion binding]; other site
929506008377	FtsK/SpoIIIE family; Region: FtsK_SpoIIIE; pfam01580
929506008378	spore photoproduct lyase; Region: photo_TT_lyase; TIGR04070
929506008379	DNA repair photolyase [DNA replication, recombination, and repair]; Region: SplB; COG1533
929506008380	Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392
929506008381	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG4584
929506008382	DNA binding site [nucleotide binding]
929506008383	Integrase core domain; Region: rve; pfam00665
929506008384	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cl17189
929506008385	HipA-like C-terminal domain; Region: HipA_C; pfam07804
929506008386	RelA- and SpoT-like ppGpp Synthetases and Hydrolases, catalytic domain; Region: Rel-Spo_like; cl11966
929506008387	metal binding triad [ion binding]; metal-binding site
929506008388	Tubulin/FtsZ: Family includes tubulin alpha-, beta-, gamma-, delta-, and epsilon-tubulins as well as FtsZ, all of which are involved in polymer formation. Tubulin is the major component of microtubules, but also exists as a heterodimer and as a curved...; Region: Tubulin_FtsZ; cl10017
929506008389	nucleotide binding site [chemical binding]; other site
929506008390	Predicted hydrolase (metallo-beta-lactamase superfamily) [General function prediction only]; Region: ComEC; COG2333
929506008391	Metallo-beta-lactamase superfamily; Region: Lactamase_B; smart00849
929506008392	Linear amide C-N hydrolases, choloylglycine hydrolase family; Region: CBAH; pfam02275
929506008393	The Ntn hydrolases (N-terminal nucleophile) are a diverse superfamily of of enzymes that are activated autocatalytically via an N-terminally lcated nucleophilic amino acid.  N-terminal nucleophile (NTN-) hydrolase superfamily, which contains a...; Region: Ntn_hydrolase; cl00467
929506008394	active site
929506008395	Site-specific recombinase XerD [DNA replication, recombination, and repair]; Region: XerD; COG4974
929506008396	DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213
929506008397	active site
929506008398	DNA binding site [nucleotide binding]
929506008399	Int/Topo IB signature motif; other site
929506008400	Protein of unknown function (DUF805); Region: DUF805; pfam05656
929506008401	Helix-Turn-Helix DNA binding domain of the transcription regulators TipAL, Mta, and SkgA; Region: HTH_TipAL-Mta; cd01106
929506008402	MerR HTH family regulatory protein; Region: MerR_1; pfam13411
929506008403	DNA binding residues [nucleotide binding]
929506008404	dimer interface [polypeptide binding]; other site
929506008405	Catalytic domain of Bacillus cereus phosphatidylinositol-specific phospholipases C and similar proteins; Region: PI-PLCc_BcPLC_like; cd08586
929506008406	active site
929506008407	catalytic site [active]
929506008408	putative metal binding site [ion binding]; other site
929506008409	O-Methyltransferase involved in polyketide biosynthesis [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG3315
929506008410	Leucine carboxyl methyltransferase; Region: LCM; pfam04072
929506008411	Predicted hydrolase (metallo-beta-lactamase superfamily) [General function prediction only]; Region: ComEC; COG2333
929506008412	Metallo-beta-lactamase superfamily; Region: Lactamase_B; smart00849
929506008413	Aerolysin toxin; Region: Aerolysin; pfam01117
929506008414	clostripain; Region: clostrip; TIGR02806
929506008415	Protein of unknown function (DUF1706); Region: DUF1706; pfam08020
929506008416	Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392
929506008417	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG4584
929506008418	DNA binding site [nucleotide binding]
929506008419	Integrase core domain; Region: rve; pfam00665
929506008420	transposase/IS protein; Provisional; Region: PRK09183
929506008421	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
929506008422	Walker A motif; other site
929506008423	ATP binding site [chemical binding]; other site
929506008424	Walker B motif; other site
929506008425	arginine finger; other site
929506008426	C-terminal processing peptidase family S41; Region: Peptidase_S41; cl02526
929506008427	Active site serine [active]
929506008428	PD-(D/E)XK nuclease family transposase; Region: PDDEXK_2; pfam12784
929506008429	conserved hypothetical protein (putative transposase or invertase); Region: T_den_put_tspse; TIGR01784
929506008430	Domain of unknown function (DUF4263); Region: DUF4263; pfam14082
929506008431	Probable transposase; Region: OrfB_IS605; pfam01385
929506008432	Putative transposase DNA-binding domain; Region: OrfB_Zn_ribbon; pfam07282
929506008433	Ribbon-helix-helix domain; Region: RHH_3; pfam12651
929506008434	Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396
929506008435	Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093
929506008436	non-specific DNA binding site [nucleotide binding]; other site
929506008437	salt bridge; other site
929506008438	sequence-specific DNA binding site [nucleotide binding]; other site
929506008439	Protein of unknown function (DUF3887); Region: DUF3887; pfam13026
929506008440	Putative membrane peptidase family (DUF2324); Region: DUF2324; pfam10086
929506008441	Signal transduction histidine kinase regulating citrate/malate metabolism [Signal transduction mechanisms]; Region: CitA; COG3290
929506008442	Response regulator of the LytR/AlgR family [Transcription / Signal transduction mechanisms]; Region: LytT; COG3279
929506008443	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
929506008444	active site
929506008445	phosphorylation site [posttranslational modification]
929506008446	intermolecular recognition site; other site
929506008447	dimerization interface [polypeptide binding]; other site
929506008448	LytTr DNA-binding domain; Region: LytTR; smart00850
929506008449	PD-(D/E)XK nuclease family transposase; Region: PDDEXK_2; pfam12784
929506008450	conserved hypothetical protein (putative transposase or invertase); Region: T_den_put_tspse; TIGR01784
929506008451	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cl17189
929506008452	Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392
929506008453	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG4584
929506008454	DNA binding site [nucleotide binding]
929506008455	Integrase core domain; Region: rve; pfam00665
929506008456	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3677
929506008457	InsA N-terminal domain; Region: Zn_Tnp_IS1; pfam03811
929506008458	DDE domain; Region: DDE_Tnp_IS240; pfam13610
929506008459	Integrase core domain; Region: rve; pfam00665
929506008460	Integrase core domain; Region: rve_3; pfam13683
929506008461	RNA polymerase sigma factor, sigma-70 family; Region: sigma70-ECF; TIGR02937
929506008462	Sigma-70 region 2; Region: Sigma70_r2; pfam04542
929506008463	Protein of unknown function (DUF2762); Region: DUF2762; pfam10960
929506008464	Protein of unknown function (DUF1659); Region: DUF1659; pfam07872
929506008465	Protein of unknown function (DUF2922); Region: DUF2922; pfam11148
929506008466	Replication initiation and membrane attachment; Region: DnaB_2; pfam07261
929506008467	Helix-turn-helix domain; Region: HTH_17; pfam12728
929506008468	Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396
929506008469	Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093
929506008470	non-specific DNA binding site [nucleotide binding]; other site
929506008471	salt bridge; other site
929506008472	sequence-specific DNA binding site [nucleotide binding]; other site
929506008473	Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396
929506008474	Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093
929506008475	non-specific DNA binding site [nucleotide binding]; other site
929506008476	salt bridge; other site
929506008477	sequence-specific DNA binding site [nucleotide binding]; other site
929506008478	Trimeric dUTP diphosphatases; Region: trimeric_dUTPase; cd07557
929506008479	trimer interface [polypeptide binding]; other site
929506008480	active site
929506008481	ABC-2 family transporter protein; Region: ABC2_membrane_4; pfam12730
929506008482	ABC-type multidrug transport system, ATPase component [Defense mechanisms]; Region: CcmA; COG1131
929506008483	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
929506008484	Walker A/P-loop; other site
929506008485	ATP binding site [chemical binding]; other site
929506008486	Q-loop/lid; other site
929506008487	ABC transporter signature motif; other site
929506008488	Walker B; other site
929506008489	D-loop; other site
929506008490	H-loop/switch region; other site
929506008491	Nucleotidyltransferase (NT) domain of ClassII CCA-adding enzymes; Region: NT_ClassII-CCAase; cd05398
929506008492	tRNA nucleotidyltransferase/poly(A) polymerase [Translation, ribosomal structure and biogenesis]; Region: PcnB; COG0617
929506008493	active site
929506008494	NTP binding site [chemical binding]; other site
929506008495	metal binding triad [ion binding]; metal-binding site
929506008496	Probable RNA and SrmB- binding site of polymerase A; Region: PolyA_pol_RNAbd; pfam12627
929506008497	tRNA nucleotidyltransferase domain 2 putative; Region: tRNA_NucTran2_2; pfam13735
929506008498	Predicted nucleotidyltransferase [General function prediction only]; Region: COG3541
929506008499	Predicted nucleotidyltransferase; Region: Nuc-transf; cl01417
929506008500	CRISPR/Cas system-associated protein Cas3'' Region: Cas3''_I; cd09641
929506008501	DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cl17251
929506008502	CRISPR-associated helicase Cas3; Region: cas3_core; TIGR01587
929506008503	Transposase, Mutator family; Region: Transposase_mut; pfam00872
929506008504	MULE transposase domain; Region: MULE; pfam10551
929506008505	potential frameshift: common BLAST hit: gi|260688336|ref|YP_003219470.1| CRISPR-associated autoregulator
929506008506	CRISPR/Cas system-associated RAMP superfamily protein Cas7; Region: Cas7_I; cl00803
929506008507	CRISPR associated protein Cas6; Region: Cas_Cas6; pfam01881
929506008508	CRISPR/Cas system-associated RAMP superfamily protein Cas5; Region: Cas5_I; cd09693
929506008509	Cache domain; Region: Cache_1; pfam02743
929506008510	Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cl01054
929506008511	dimerization interface [polypeptide binding]; other site
929506008512	Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386
929506008513	Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer); Region: MA; smart00283
929506008514	Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386
929506008515	dimer interface [polypeptide binding]; other site
929506008516	putative CheW interface [polypeptide binding]; other site
929506008517	Fatty acyltransferase-like subfamily of the SGNH hydrolases, a diverse family of lipases and esterases. The tertiary fold of the enzyme is substantially different from that of the alpha/beta hydrolase family and unique among all known hydrolases; its...; Region: fatty_acyltransferase_like; cd01846
929506008518	active site
929506008519	catalytic triad [active]
929506008520	oxyanion hole [active]
929506008521	Restriction endonuclease; Region: Mrr_cat; pfam04471
929506008522	Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396
929506008523	Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093
929506008524	non-specific DNA binding site [nucleotide binding]; other site
929506008525	salt bridge; other site
929506008526	sequence-specific DNA binding site [nucleotide binding]; other site
929506008527	Plasmid segregation protein ParM and similar proteins; Region: ParM_like; cd10227
929506008528	Mg binding site [ion binding]; other site
929506008529	nucleotide binding site [chemical binding]; other site
929506008530	putative protofilament interface [polypeptide binding]; other site
929506008531	Muramidase (flagellum-specific) [Cell motility and secretion / Intracellular trafficking and secretion]; Region: FlgJ; COG1705
929506008532	N-acetylmuramoyl-L-alanine amidase or MurNAc-LAA (also known as peptidoglycan aminohydrolase, NAMLA amidase, NAMLAA, Amidase 3, and peptidoglycan amidase; EC 3.5.1.28) is an autolysin that hydrolyzes the amide bond between N-acetylmuramoyl and L-amino...; Region: MurNAc-LAA; cd02696
929506008533	active site
929506008534	metal binding site [ion binding]; metal-binding site
929506008535	Prophage endopeptidase tail; Region: Prophage_tail; cl12123
929506008536	SGNH_hydrolase, or GDSL_hydrolase, is a diverse family of lipases and esterases. The tertiary fold of the enzyme is substantially different from that of the alpha/beta hydrolase family and unique among all known hydrolases; its active site closely...; Region: SGNH_hydrolase; cd00229
929506008537	active site
929506008538	oxyanion hole [active]
929506008539	catalytic triad [active]
929506008540	Phage tail protein; Region: Sipho_tail; cl17486
929506008541	The Bin/Amphiphysin/Rvs (BAR) domain, a dimerization module that binds membranes and detects membrane curvature; Region: BAR; cl12013
929506008542	Phage-related minor tail protein; Region: PhageMin_Tail; pfam10145
929506008543	rhamnulose-1-phosphate aldolase/alcohol dehydrogenase; Region: RhaD_aldol-ADH; TIGR02632
929506008544	phage major tail protein, phi13 family; Region: maj_tail_phi13; TIGR01603
929506008545	Bacteriophage protein of unknown function (DUF646); Region: DUF646; pfam04883
929506008546	Phage head-tail joining protein; Region: Phage_H_T_join; pfam05521
929506008547	phage major capsid protein, HK97 family; Region: major_cap_HK97; TIGR01554
929506008548	Phage capsid family; Region: Phage_capsid; pfam05065
929506008549	Caseinolytic protease (ClpP) is an ATP-dependent, highly conserved serine protease; Region: S14_ClpP_1; cd07016
929506008550	oligomer interface [polypeptide binding]; other site
929506008551	active site residues [active]
929506008552	phage portal protein, HK97 family; Region: portal_HK97; TIGR01537
929506008553	Phage terminase-like protein, large subunit [General function prediction only]; Region: COG4626
929506008554	Helix-turn-helix domain; Region: HTH_28; pfam13518
929506008555	Phage terminase, small subunit; Region: Terminase_4; cl01525
929506008556	INT_SG3, DNA breaking-rejoining enzymes, integrase/recombinases subgroup 3, catalytic domain. The CD contains various predicted bacterial and phage integrase/recombinase sequences for which not much experimental characterization is available; Region: INT_SG3_C; cd01186
929506008557	Int/Topo IB signature motif; other site
929506008558	RNA polymerase factor sigma-32; Reviewed; Region: rpoH2; PRK07500
929506008559	Domain of Unknown Function (DUF1599); Region: DUF1599; pfam07659
929506008560	hypothetical protein; Provisional; Region: PRK13795
929506008561	Adenine nucleotide alpha hydrolases superfamily including N type ATP PPases, ATP sulphurylases Universal Stress Response protein and electron transfer flavoprotein (ETF). The domain forms a apha/beta/apha fold which  binds to Adenosine nucleotide; Region: AANH_like; cl00292
929506008562	Ligand Binding Site [chemical binding]; other site
929506008563	Helix-turn-helix domain; Region: HTH_36; pfam13730
929506008564	Replication initiation and membrane attachment; Region: DnaB_2; pfam07261
929506008565	ORF6N domain; Region: ORF6N; pfam10543
929506008566	ORF6C domain; Region: ORF6C; pfam10552