-- dump date 20140619_043143 -- class Genbank::misc_feature -- table misc_feature_note -- id note 441771000001 chromosomal replication initiation protein; Reviewed; Region: dnaA; PRK00149 441771000002 DnaA N-terminal domain; Region: DnaA_N; pfam11638 441771000003 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 441771000004 Walker A motif; other site 441771000005 ATP binding site [chemical binding]; other site 441771000006 Walker B motif; other site 441771000007 arginine finger; other site 441771000008 C-terminal domain of bacterial DnaA proteins. The DNA-binding C-terminal domain of DnaA contains a helix-turn-helix motif that specifically interacts with the DnaA box, a 9-mer motif that occurs repetitively in the replication origin oriC. Multiple...; Region: Bac_DnaA_C; cd06571 441771000009 DnaA box-binding interface [nucleotide binding]; other site 441771000010 DNA polymerase III subunit beta; Validated; Region: PRK05643 441771000011 Beta clamp domain. The beta subunit (processivity factor) of DNA polymerase III holoenzyme, refered to as the beta clamp, forms a ring shaped dimer that encircles dsDNA (sliding clamp) in bacteria. The beta-clamp is structurally similar to the trimeric...; Region: beta_clamp; cd00140 441771000012 putative DNA binding surface [nucleotide binding]; other site 441771000013 dimer interface [polypeptide binding]; other site 441771000014 beta-clamp/clamp loader binding surface; other site 441771000015 beta-clamp/translesion DNA polymerase binding surface; other site 441771000016 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 441771000017 RNA binding surface [nucleotide binding]; other site 441771000018 recombination protein F; Reviewed; Region: recF; PRK00064 441771000019 ATP-binding cassette domain of RecF; Region: ABC_RecF; cd03242 441771000020 Walker A/P-loop; other site 441771000021 ATP binding site [chemical binding]; other site 441771000022 Q-loop/lid; other site 441771000023 ABC transporter signature motif; other site 441771000024 Walker B; other site 441771000025 D-loop; other site 441771000026 H-loop/switch region; other site 441771000027 DNA gyrase subunit B; Validated; Region: gyrB; PRK05644 441771000028 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 441771000029 ATP binding site [chemical binding]; other site 441771000030 Mg2+ binding site [ion binding]; other site 441771000031 G-X-G motif; other site 441771000032 TopoIIA_Trans_DNA_gyrase: Transducer domain, having a ribosomal S5 domain 2-like fold, of the type found in proteins of the type IIA family of DNA topoisomerases similar to the B subunits of E. coli DNA gyrase and E. coli Topoisomerase IV which are; Region: TopoII_Trans_DNA_gyrase; cd00822 441771000033 anchoring element; other site 441771000034 dimer interface [polypeptide binding]; other site 441771000035 ATP binding site [chemical binding]; other site 441771000036 TOPRIM_TopoIIA_GyrB: topoisomerase-primase (TOPRIM) nucleotidyl transferase/hydrolase domain of the type found in proteins of the type IIA family of DNA topoisomerases similar to the Escherichia coli GyrB subunit. TopoIIA enzymes cut both strands of the...; Region: TOPRIM_TopoIIA_GyrB; cd03366 441771000037 active site 441771000038 putative metal-binding site [ion binding]; other site 441771000039 DNA gyrase B subunit, carboxyl terminus; Region: DNA_gyraseB_C; pfam00986 441771000040 DNA gyrase subunit A; Validated; Region: PRK05560 441771000041 DNA Topoisomerase, subtype IIA; domain A'; bacterial DNA topoisomerase IV (C subunit, ParC), bacterial DNA gyrases (A subunit, GyrA),mammalian DNA toposiomerases II. DNA topoisomerases are essential enzymes that regulate the conformational changes...; Region: TOP4c; cd00187 441771000042 CAP-like domain; other site 441771000043 active site 441771000044 primary dimer interface [polypeptide binding]; other site 441771000045 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 441771000046 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 441771000047 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 441771000048 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 441771000049 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 441771000050 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 441771000051 CRISPR/Cas system-associated protein Cas10; Region: Cas10_III; cd09680 441771000052 Predicted small molecule binding protein (contains 3H domain) [General function prediction only]; Region: COG1827 441771000053 HTH domain; Region: HTH_11; pfam08279 441771000054 3H domain; Region: 3H; pfam02829 441771000055 Domain of unknown function (DUF362); Region: DUF362; pfam04015 441771000056 RPB11 and RPB3 subunits of RNA polymerase; Region: RNAP_RPB11_RPB3; cl11409 441771000057 4Fe-4S dicluster domain; Region: Fer4_7; pfam12838 441771000058 hypothetical protein; Validated; Region: PRK00068 441771000059 Uncharacterized protein conserved in bacteria [Function unknown]; Region: ErfK; COG1376 441771000060 L,D-transpeptidase catalytic domain; Region: YkuD; pfam03734 441771000061 Predicted dehydrogenase [General function prediction only]; Region: COG0579 441771000062 hydroxyglutarate oxidase; Provisional; Region: PRK11728; cl19156 441771000063 BFD-like [2Fe-2S] binding domain; Region: Fer2_BFD; pfam04324 441771000064 Protein of unknown function (DUF1667); Region: DUF1667; pfam07892 441771000065 seryl-tRNA synthetase; Provisional; Region: PRK05431 441771000066 Seryl-tRNA synthetase N-terminal domain; Region: Seryl_tRNA_N; pfam02403 441771000067 Seryl-tRNA synthetase (SerRS) class II core catalytic domain. SerRS is responsible for the attachment of serine to the 3' OH group of ribose of the appropriate tRNA. This domain It is primarily responsible for ATP-dependent formation of the enzyme...; Region: SerRS_core; cd00770 441771000068 dimer interface [polypeptide binding]; other site 441771000069 active site 441771000070 motif 1; other site 441771000071 motif 2; other site 441771000072 motif 3; other site 441771000073 ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136 441771000074 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 441771000075 Walker A/P-loop; other site 441771000076 ATP binding site [chemical binding]; other site 441771000077 Q-loop/lid; other site 441771000078 ABC transporter signature motif; other site 441771000079 Walker B; other site 441771000080 D-loop; other site 441771000081 H-loop/switch region; other site 441771000082 ABC-2 family transporter protein; Region: ABC2_membrane_4; pfam12730 441771000083 ABC-2 family transporter protein; Region: ABC2_membrane_4; pfam12730 441771000084 phosphatidylserine decarboxylase; Provisional; Region: PRK00723 441771000085 2-polyprenylphenol 6-hydroxylase; Region: UbiB; TIGR01982 441771000086 Predicted unusual protein kinase [General function prediction only]; Region: AarF; COG0661 441771000087 active site 441771000088 ATP binding site [chemical binding]; other site 441771000089 Uncharacterized conserved protein [Function unknown]; Region: COG3937 441771000090 Transcriptional regulator of aromatic amino acids metabolism [Transcription / Amino acid transport and metabolism]; Region: TyrR; COG3283 441771000091 ACT domains are commonly involved in specifically binding an amino acid or other small ligand leading to regulation of the enzyme; Region: ACT; cl09141 441771000092 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 441771000093 Walker A motif; other site 441771000094 ATP binding site [chemical binding]; other site 441771000095 Walker B motif; other site 441771000096 arginine finger; other site 441771000097 CGS_like: Cystathionine gamma-synthase is a PLP dependent enzyme and catalyzes the committed step of methionine biosynthesis. This pathway is unique to microorganisms and plants, rendering the enzyme an attractive target for the development of...; Region: CGS_like; cd00614 441771000098 homodimer interface [polypeptide binding]; other site 441771000099 substrate-cofactor binding pocket; other site 441771000100 pyridoxal 5'-phosphate binding site [chemical binding]; other site 441771000101 catalytic residue [active] 441771000102 Nucleoside deaminases include adenosine, guanine and cytosine deaminases. These enzymes are Zn dependent and catalyze the deamination of nucleosides. The zinc ion in the active site plays a central role in the proposed catalytic mechanism, activating a...; Region: nucleoside_deaminase; cd01285 441771000103 nucleoside/Zn binding site; other site 441771000104 dimer interface [polypeptide binding]; other site 441771000105 catalytic motif [active] 441771000106 DNA polymerase III subunits gamma and tau; Validated; Region: PRK05563 441771000107 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 441771000108 Walker A motif; other site 441771000109 ATP binding site [chemical binding]; other site 441771000110 Walker B motif; other site 441771000111 arginine finger; other site 441771000112 DNA polymerase III subunits gamma and tau domain III; Region: DNA_pol3_gamma3; pfam12169 441771000113 hypothetical protein; Validated; Region: PRK00153 441771000114 recombination protein RecR; Reviewed; Region: recR; PRK00076 441771000115 endonuclease III; includes endonuclease III (DNA-(apurinic or apyrimidinic site) lyase), alkylbase DNA glycosidases (Alka-family) and other DNA glycosidases; Region: ENDO3c; cl19066 441771000116 helix-hairpin-helix signature motif; other site 441771000117 RecR protein; Region: RecR; pfam02132 441771000118 TOPRIM_recR: topoisomerase-primase (TOPRIM) nucleotidyl transferase/hydrolase domain of the type found in Escherichia coli RecR. RecR participates in the RecFOR pathway of homologous recombinational repair in prokaryotes. This pathway provides a...; Region: TOPRIM_recR; cd01025 441771000119 putative active site [active] 441771000120 putative metal-binding site [ion binding]; other site 441771000121 tetramer interface [polypeptide binding]; other site 441771000122 Protein of unknown function (DUF2508); Region: DUF2508; pfam10704 441771000123 pro-sigmaK processing inhibitor BofA; Region: spore_BofA; TIGR02862 441771000124 putative DNA-binding transcriptional regulator; Reviewed; Region: PRK00347 441771000125 Nudix hydrolase is a superfamily of enzymes found in all three kingdoms of life, and it catalyzes the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+...; Region: Nudix_Hydrolase; cl00447 441771000126 nudix motif; other site 441771000127 TIM barrel proteins share a structurally conserved phosphate binding motif and in general share an eight beta/alpha closed barrel structure. Specific for this family is the conserved phosphate binding site at the edges of strands 7 and 8. The phosphate...; Region: TIM_phosphate_binding; cl17186 441771000128 Flavodoxins [Energy production and conversion]; Region: FldA; COG0716 441771000129 Largest subunit of RNA polymerase (RNAP), N-terminal domain; Region: RNAP_largest_subunit_N; cl19114 441771000130 The HCP family of iron-sulfur proteins includes hybrid cluster protein (HCP), acetyl-CoA synthase (ACS), and carbon monoxide dehydrogenase (CODH), all of which contain [Fe4-S4] metal clusters at their active sites. These proteins have a conserved...; Region: HCP_like; cl19102 441771000131 4Fe-4S dicluster domain; Region: Fer4_7; pfam12838 441771000132 Dinucleotide-utilizing enzymes involved in molybdopterin and thiamine biosynthesis family 1 [Coenzyme metabolism]; Region: COG1179 441771000133 Family of activating enzymes (E1) of ubiquitin-like proteins related to the E.coli hypothetical protein ygdL. The common reaction mechanism catalyzed by E1-like enzymes begins with a nucleophilic attack of the C-terminal carboxylate of the ubiquitin-like...; Region: YgdL_like; cd00755 441771000134 putative ATP binding site [chemical binding]; other site 441771000135 putative substrate interface [chemical binding]; other site 441771000136 Fucose permease [Carbohydrate transport and metabolism]; Region: FucP; COG0738 441771000137 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 441771000138 putative substrate translocation pore; other site 441771000139 Acetyltransferases, including N-acetylases of ribosomal proteins [Translation, ribosomal structure and biogenesis]; Region: RimL; COG1670 441771000140 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl17182 441771000141 Family 4 Uracil-DNA glycosylase (UDG), found exclusively in thermophilic organisms; Region: UDG_F4_TTUDGA_like; cd10030 441771000142 active site 441771000143 Fe-S cluster binding site [ion binding]; other site 441771000144 RNA polymerase factor sigma-70; Validated; Region: PRK06811 441771000145 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 441771000146 Sigma-70, region 4; Region: Sigma70_r4_2; pfam08281 441771000147 DNA binding residues [nucleotide binding] 441771000148 Domain of unknown function (DUF4179); Region: DUF4179; pfam13786 441771000149 SurA N-terminal domain; Region: SurA_N_3; cl07813 441771000150 PPIC-type PPIASE domain; Region: Rotamase_2; cl08278 441771000151 NAD-dependent deacetylase; Provisional; Region: PRK00481 441771000152 LD-Carboxypeptidase, a serine protease, includes microcin C7 self immunity protein; Region: Peptidase_S66; cd07025 441771000153 dimer interface [polypeptide binding]; other site 441771000154 catalytic triad [active] 441771000155 CorA-like Mg2+ transporter protein; Region: CorA; pfam01544 441771000156 uncharacterized bacterial subfamily of the Escherichia coli CorA-Salmonella typhimurium ZntB family; Region: EcCorA_ZntB-like_u2; cd12827 441771000157 Cl binding site [ion binding]; other site 441771000158 oligomer interface [polypeptide binding]; other site 441771000159 Inhibitor of sigma-G Gin; Region: Gin; pfam10764 441771000160 Arginine/lysine/ornithine decarboxylases [Amino acid transport and metabolism]; Region: LdcC; COG1982 441771000161 Ornithine decarboxylase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD corresponds to ornithine decarboxylase (ODC), arginine decarboxylase (ADC) and lysine...; Region: Orn_deC_like; cd00615 441771000162 homodimer interface [polypeptide binding]; other site 441771000163 pyridoxal 5'-phosphate binding site [chemical binding]; other site 441771000164 catalytic residue [active] 441771000165 Orn/Lys/Arg decarboxylase, C-terminal domain; Region: OKR_DC_1_C; pfam03711 441771000166 Thymidylate kinase [Nucleotide transport and metabolism]; Region: Tmk; COG0125 441771000167 thymidylate kinase; Provisional; Region: PRK13975; cl17243 441771000168 Protein of unknown function (DUF970); Region: DUF970; pfam06153 441771000169 DNA polymerase III subunit delta'; Validated; Region: PRK05564 441771000170 DNA polymerase III subunit delta'; Validated; Region: PRK08485 441771000171 Uncharacterized homolog of PSP1 [Function unknown]; Region: COG1774 441771000172 Heavy-metal-associated domain (HMA) is a conserved domain of approximately 30 amino acid residues found in a number of proteins that transport or detoxify heavy metals, for example, the CPx-type heavy metal ATPases and copper chaperones. HMA domain...; Region: HMA; cd00371 441771000173 4Fe-4S dicluster domain; Region: Fer4_7; pfam12838 441771000174 The HCP family of iron-sulfur proteins includes hybrid cluster protein (HCP), acetyl-CoA synthase (ACS), and carbon monoxide dehydrogenase (CODH), all of which contain [Fe4-S4] metal clusters at their active sites. These proteins have a conserved...; Region: HCP_like; cl19102 441771000175 Predicted O-methyltransferase [General function prediction only]; Region: COG4123 441771000176 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 441771000177 S-adenosylmethionine binding site [chemical binding]; other site 441771000178 Ribosomal RNA small subunit methyltransferase I, also known as rRNA (cytidine-2'-O-)-methyltransferase RsmI; Region: RsmI; cd11648 441771000179 putative SAM binding site [chemical binding]; other site 441771000180 putative homodimer interface [polypeptide binding]; other site 441771000181 Apolipophorin-III and similar insect proteins; Region: ApoLp-III_like; cl19113 441771000182 Cell wall-associated hydrolases (invasion-associated proteins) [Cell envelope biogenesis, outer membrane]; Region: Spr; COG0791 441771000183 NlpC/P60 family; Region: NLPC_P60; pfam00877 441771000184 Regulators of stationary/sporulation gene expression [Transcription]; Region: AbrB; COG2002 441771000185 Domain of unknown function (DUF1836); Region: DUF1836; pfam08876 441771000186 Amidinotransferase; Region: Amidinotransf; cl19186 441771000187 MECDP_synthase (2-C-methyl-D-erythritol-2,4-cyclodiphosphate synthase), encoded by the ispF gene, catalyzes the formation of 2-C-methyl-D-erythritol 2,4-cyclodiphosphate (MEC) in the non-mevalonate deoxyxylulose (DOXP) pathway for isoprenoid biosynthesis; Region: MECDP_synthase; cd00554 441771000188 homotrimer interaction site [polypeptide binding]; other site 441771000189 zinc binding site [ion binding]; other site 441771000190 CDP-binding sites; other site 441771000191 Predicted xylanase/chitin deacetylase [Carbohydrate transport and metabolism]; Region: CDA1; COG0726 441771000192 Putative catalytic NodB homology domain of PgaB, IcaB, and similar proteins which consist of a deformed (beta/alpha)8 barrel fold with 5- or 6-strands; Region: CE4_NodB_like_5s_6s; cd10918 441771000193 putative active site [active] 441771000194 putative metal binding site [ion binding]; other site 441771000195 Uncharacterized membrane protein, required for spore maturation in B.subtilis. [General function prediction only]; Region: SpmA; COG2715 441771000196 Uncharacterized membrane protein [Function unknown]; Region: SpmB; COG0700 441771000197 Na+-driven multidrug efflux pump [Defense mechanisms]; Region: NorM; COG0534 441771000198 Subfamily of the multidrug and toxic compound extrusion (MATE)-like proteins similar to Thermotoga marina NorM; Region: MATE_NorM_like; cd13137 441771000199 Family 4 Uracil-DNA glycosylase (UDG), found exclusively in thermophilic organisms; Region: UDG_F4_TTUDGA_like; cd10030 441771000200 Fe-S cluster binding site [ion binding]; other site 441771000201 active site 441771000202 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cl17220 441771000203 Transcriptional regulators [Transcription]; Region: MarR; COG1846 441771000204 methionyl-tRNA synthetase; Reviewed; Region: PRK12267 441771000205 catalytic core domain of methioninyl-tRNA synthetases; Region: MetRS_core; cd00814 441771000206 active site 441771000207 HIGH motif; other site 441771000208 KMSKS motif; other site 441771000209 Anticodon-binding domain of methionyl tRNA synthetases; Region: Anticodon_Ia_Met; cd07957 441771000210 tRNA binding surface [nucleotide binding]; other site 441771000211 anticodon binding site; other site 441771000212 tRNA-binding-domain-containing Escherichia coli methionyl-tRNA synthetase (EcMetRS)-like proteins. This family includes EcMetRS and Aquifex aeolicus Trbp111 (AaTrbp111). This domain has general tRNA binding properties. MetRS aminoacylates methionine...; Region: tRNA_bind_EcMetRS_like; cd02800 441771000213 dimer interface [polypeptide binding]; other site 441771000214 putative tRNA-binding site [nucleotide binding]; other site 441771000215 Protein of unknown function (DUF445); Region: DUF445; pfam04286 441771000216 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4399; cl19827 441771000217 Predicted metal-dependent hydrolases with the TIM-barrel fold [General function prediction only]; Region: COG1099 441771000218 TatD like proteins; E.coli TatD is a cytoplasmic protein, shown to have magnesium dependent DNase activity; Region: TatD_DNAse; cd01310 441771000219 active site 441771000220 Domain of unknown function (DUF348); Region: DUF348; pfam03990 441771000221 Domain of unknown function (DUF348); Region: DUF348; pfam03990 441771000222 G5 domain; Region: G5; pfam07501 441771000223 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3584 441771000224 ribonuclease M5; Region: 5S_RNA_mat_M5; TIGR00334 441771000225 TOPRIM_ RNase M5_like: The topoisomerase-primase (TOPRIM) nucleotidyl transferase/hydrolase domain found in Ribonuclease M5: (RNase M5) and other small primase-like proteins from bacteria and archaea. RNase M5 catalyzes the maturation of 5S rRNA in low...; Region: TOPRIM_RNase_M5_like; cd01027 441771000226 putative active site [active] 441771000227 putative metal binding site [ion binding]; other site 441771000228 Domain of unknown function (DUF4093); Region: DUF4093; pfam13331 441771000229 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 441771000230 S-adenosylmethionine binding site [chemical binding]; other site 441771000231 Protein of unknown function (DUF1510); Region: DUF1510; pfam07423 441771000232 glideosome-associated protein 45; Provisional; Region: PTZ00423 441771000233 Membrane-fusion protein [Cell envelope biogenesis, outer membrane]; Region: AcrA; COG0845 441771000234 HlyD family secretion protein; Region: HlyD_3; pfam13437 441771000235 ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136 441771000236 ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255 441771000237 Walker A/P-loop; other site 441771000238 ATP binding site [chemical binding]; other site 441771000239 Q-loop/lid; other site 441771000240 ABC transporter signature motif; other site 441771000241 Walker B; other site 441771000242 D-loop; other site 441771000243 H-loop/switch region; other site 441771000244 MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704 441771000245 ABC-type antimicrobial peptide transport system, permease component [Defense mechanisms]; Region: SalY; COG0577 441771000246 FtsX-like permease family; Region: FtsX; pfam02687 441771000247 ATPases involved in chromosome partitioning [Cell division and chromosome partitioning]; Region: Soj; COG1192 441771000248 MRP (Multiple Resistance and pH adaptation) is a homologue of the Fer4_NifH superfamily. Like the other members of the superfamily, MRP contains a ATP-binding domain at the N-termini. It is found in bacteria as a membrane-spanning protein and functions...; Region: MRP-like; cd02037 441771000249 Walker A motif; other site 441771000250 4Fe-4S single cluster domain; Region: Fer4_15; pfam13459 441771000251 GAF domain; Region: GAF_2; pfam13185 441771000252 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 441771000253 metal binding site [ion binding]; metal-binding site 441771000254 active site 441771000255 I-site; other site 441771000256 Uncharacterized membrane protein [Function unknown]; Region: SapB; COG1285 441771000257 MgtC family; Region: MgtC; pfam02308 441771000258 anaerobic ribonucleoside triphosphate reductase; Provisional; Region: PRK07111 441771000259 ATP cone domain; Region: ATP-cone; pfam03477 441771000260 Class III ribonucleotide reductase; Region: RNR_III; cd01675 441771000261 effector binding site; other site 441771000262 active site 441771000263 Zn binding site [ion binding]; other site 441771000264 glycine loop; other site 441771000265 4Fe-4S single cluster domain; Region: Fer4_12; pfam13353 441771000266 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 441771000267 FeS/SAM binding site; other site 441771000268 Protein of unknown function (DUF1048); Region: DUF1048; cl01986 441771000269 Vault protein inter-alpha-trypsin domain; Region: VIT; cl02699 441771000270 Predicted transcriptional regulators [Transcription]; Region: COG1695 441771000271 putative DNA binding site [nucleotide binding]; other site 441771000272 putative Zn2+ binding site [ion binding]; other site 441771000273 Beta-lactamase superfamily domain; Region: Lactamase_B_3; pfam13483 441771000274 isoleucyl-tRNA synthetase; Reviewed; Region: ileS; PRK06039 441771000275 catalytic core domain of isoleucyl-tRNA synthetases; Region: IleRS_core; cd00818 441771000276 active site 441771000277 HIGH motif; other site 441771000278 KMSKS motif; other site 441771000279 Anticodon-binding domain of archaeal, bacterial, and eukaryotic cytoplasmic isoleucyl tRNA synthetases; Region: Anticodon_Ia_Ile_ABEc; cd07961 441771000280 tRNA binding surface [nucleotide binding]; other site 441771000281 anticodon binding site; other site 441771000282 Transcriptional regulators [Transcription]; Region: PurR; COG1609 441771000283 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 441771000284 DNA binding site [nucleotide binding] 441771000285 domain linker motif; other site 441771000286 Type 1 periplasmic binding fold superfamily; Region: Periplasmic_Binding_Protein_Type_1; cl10011 441771000287 Part of AAA domain; Region: AAA_19; pfam13245 441771000288 Superfamily I DNA and RNA helicases and helicase subunits [DNA replication, recombination, and repair]; Region: COG1112 441771000289 AAA domain; Region: AAA_12; pfam13087 441771000290 Mannose-1-phosphate guanylyltransferase [Cell envelope biogenesis, outer membrane]; Region: {ManC}; COG0836 441771000291 GDP-M1P_Guanylyltransferase catalyzes the formation of GDP-Mannose; Region: GDP-M1P_Guanylyltransferase; cd02509 441771000292 Substrate binding site; other site 441771000293 Cupin domain; Region: Cupin_2; cl17218 441771000294 Protein of unknown function DUF111; Region: DUF111; pfam01969 441771000295 ATP-utilizing enzymes of the PP-loop superfamily [General function prediction only]; Region: COG1606 441771000296 This is a subfamily of Adenine nucleotide alpha hydrolases superfamily. Adenine nucleotide alpha hydrolases superfamily includes N type ATP PPases and ATP sulphurylases. It forms a apha/beta/apha fold which binds to Adenosine group. This subfamily; Region: Alpha_ANH_like_I; cd01990 441771000297 Ligand Binding Site [chemical binding]; other site 441771000298 NCAIR mutase (PurE)-related proteins [General function prediction only]; Region: COG1691 441771000299 AIR carboxylase; Region: AIRC; smart01001 441771000300 Predicted Fe-S oxidoreductases [General function prediction only]; Region: COG0535 441771000301 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 441771000302 FeS/SAM binding site; other site 441771000303 ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653 441771000304 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; pfam01547 441771000305 This family is most closely related to the GT1 family of glycosyltransferases. mtfB (mannosyltransferase B) in E. coli has been shown to direct the growth of the O9-specific polysaccharide chain. It transfers two mannoses into the position 3 of the...; Region: GT1_mtfB_like; cd03809 441771000306 glycosyltransferase, GG-Bacteroidales peptide system; Region: glyco_rSAM_CFB; TIGR04157 441771000307 spore coat protein YsxE; Region: spore_ysxE; TIGR02904 441771000308 Phosphotransferase enzyme family; Region: APH; pfam01636 441771000309 Aminoglycoside 3'-phosphotransferase (APH) and Choline Kinase (ChoK) family. The APH/ChoK family is part of a larger superfamily that includes the catalytic domains of other kinases, such as the typical serine/threonine/tyrosine protein kinases (PKs)...; Region: APH_ChoK_like; cd05120 441771000310 substrate binding site [chemical binding]; other site 441771000311 Aminoglycoside 3'-phosphotransferase (APH) and Choline Kinase (ChoK) family. The APH/ChoK family is part of a larger superfamily that includes the catalytic domains of other kinases, such as the typical serine/threonine/tyrosine protein kinases (PKs)...; Region: APH_ChoK_like; cl17270 441771000312 Aminoglycoside 3'-phosphotransferase (APH) and Choline Kinase (ChoK) family. The APH/ChoK family is part of a larger superfamily that includes the catalytic domains of other kinases, such as the typical serine/threonine/tyrosine protein kinases (PKs)...; Region: APH_ChoK_like; cl17270 441771000313 active site 441771000314 ATP binding site [chemical binding]; other site 441771000315 substrate binding site [chemical binding]; other site 441771000316 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 441771000317 This family is most closely related to the GT1 family of glycosyltransferases. mtfB (mannosyltransferase B) in E. coli has been shown to direct the growth of the O9-specific polysaccharide chain. It transfers two mannoses into the position 3 of the...; Region: GT1_mtfB_like; cd03809 441771000318 Aminoglycoside 3'-phosphotransferase (APH) and Choline Kinase (ChoK) family. The APH/ChoK family is part of a larger superfamily that includes the catalytic domains of other kinases, such as the typical serine/threonine/tyrosine protein kinases (PKs)...; Region: APH_ChoK_like; cd05120 441771000319 active site 441771000320 substrate binding site [chemical binding]; other site 441771000321 ATP binding site [chemical binding]; other site 441771000322 Phosphotransferase enzyme family; Region: APH; pfam01636 441771000323 YabG peptidase U57; Region: Peptidase_U57; pfam05582 441771000324 Protein of unknown function (DUF1021); Region: DUF1021; pfam06257 441771000325 Domain of unknown function (DUF3794); Region: DUF3794; pfam12673 441771000326 Domain of unknown function (DUF3794); Region: DUF3794; pfam12673 441771000327 Domain of unknown function (DUF3794); Region: DUF3794; pfam12673 441771000328 FOG: LysM repeat [Cell envelope biogenesis, outer membrane]; Region: LytE; COG1388 441771000329 Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118 441771000330 Type 1 glutamine amidotransferase (GATase1)-like domain found in cyanophycinase; Region: GAT1_cyanophycinase; cd03145 441771000331 proposed catalytic triad [active] 441771000332 active site nucleophile [active] 441771000333 cyanophycin synthetase; Provisional; Region: PRK14016 441771000334 ATP-grasp domain; Region: ATP-grasp_4; cl17255 441771000335 Mur ligase middle domain; Region: Mur_ligase_M; pfam08245 441771000336 Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875 441771000337 4-diphosphocytidyl-2-C-methyl-D-erythritol kinase; Provisional; Region: ipk; PRK00128 441771000338 GHMP kinases N terminal domain; Region: GHMP_kinases_N; pfam00288 441771000339 GHMP kinases C terminal; Region: GHMP_kinases_C; pfam08544 441771000340 Bacillus/Clostridium GerA spore germination protein; Region: GerA; pfam03323 441771000341 Spore germination protein; Region: Spore_permease; cl17796 441771000342 Amino acid transporters [Amino acid transport and metabolism]; Region: PotE; COG0531 441771000343 germination protein, Ger(x)C family; Region: spore_ger_x_C; TIGR02887 441771000344 Stage II sporulation protein R (spore_II_R); Region: Spore_II_R; pfam09551 441771000345 UDP-N-acetylglucosamine:LPS N-acetylglucosamine transferase [Cell envelope biogenesis, outer membrane]; Region: MurG; COG0707 441771000346 Monogalactosyldiacylglycerol (MGDG) synthase; Region: MGDG_synth; pfam06925 441771000347 Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013 441771000348 germination protein YpeB; Region: spore_YpeB; TIGR02889 441771000349 YpeB sporulation; Region: YPEB; pfam14620 441771000350 Predicted tRNA(5-methylaminomethyl-2-thiouridylate) methyltransferase, contains the PP-loop ATPase domain [Translation, ribosomal structure and biogenesis]; Region: TrmU; COG0482 441771000351 ThiI is required for thiazole synthesis in the thiamine biosynthesis pathway. It belongs to the Adenosine Nucleotide Hydrolysis suoerfamily and predicted to bind to Adenosine nucleotide; Region: ThiI; cd01712 441771000352 Ligand Binding Site [chemical binding]; other site 441771000353 Domain of unknown function (DUF814); Region: DUF814; pfam05670 441771000354 Domain of unknown function (DUF1934); Region: DUF1934; pfam09148 441771000355 CTP synthetase; Validated; Region: pyrG; PRK05380 441771000356 CTP synthetase (CTPs) is a two-domain protein, which consists of an N-terminal synthetase domain and C-terminal glutaminase domain. The enzymes hydrolyze the amide bond of glutamine to ammonia and glutamate at the glutaminase domains and transfer nascent...; Region: CTGs; cd03113 441771000357 Catalytic site [active] 441771000358 active site 441771000359 UTP binding site [chemical binding]; other site 441771000360 Type 1 glutamine amidotransferase (GATase1) domain found in Cytidine Triphosphate Synthetase; Region: GATase1_CTP_Synthase; cd01746 441771000361 active site 441771000362 putative oxyanion hole; other site 441771000363 catalytic triad [active] 441771000364 transcription termination factor Rho; Provisional; Region: rho; PRK09376 441771000365 Rho termination factor, N-terminal domain; Region: Rho_N; pfam07498 441771000366 Rho_CSD: Rho protein cold-shock domain (CSD). Rho protein is a transcription termination factor in most bacteria. In bacteria, there are two distinct mechanisms for mRNA transcription termination. In intrinsic termination, RNA polymerase and nascent mRNA...; Region: Rho_CSD; cd04459 441771000367 RNA binding site [nucleotide binding]; other site 441771000368 RecA-like NTPases. This family includes the NTP binding domain of F1 and V1 H+ATPases, DnaB and related helicases as well as bacterial RecA and related eukaryotic and archaeal recombinases. This group also includes bacterial conjugation proteins and...; Region: RecA-like_NTPases; cl17233 441771000369 Walker A motif; other site 441771000370 ATP binding site [chemical binding]; other site 441771000371 Walker B motif; other site 441771000372 50S ribosomal protein L31; Reviewed; Region: rpmE; PRK00019 441771000373 thymidine kinase; Provisional; Region: PRK04296 441771000374 Protein of unknown function (DUF1385); Region: DUF1385; pfam07136 441771000375 protein-(glutamine-N5) methyltransferase, release factor-specific; Region: RF_mod_PrmC; TIGR03534 441771000376 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 441771000377 peptide chain release factor 1; Validated; Region: prfA; PRK00591 441771000378 This domain is found in peptide chain release factors; Region: PCRF; smart00937 441771000379 RF-1 domain; Region: RF-1; pfam00472 441771000380 Predicted divalent heavy-metal cations transporter [Inorganic ion transport and metabolism]; Region: COG0428 441771000381 Putative translation factor (SUA5) [Translation, ribosomal structure and biogenesis]; Region: SUA5; COG0009 441771000382 Putative GTP-binding controlling metal-binding; Region: SUA5; pfam03481 441771000383 Low molecular weight phosphatase family; Region: LMWPc; cd00115 441771000384 active site 441771000385 ribose-5-phosphate isomerase B; Provisional; Region: PRK05571 441771000386 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 441771000387 active site 441771000388 Cytidine and deoxycytidylate deaminase zinc-binding region. The family contains cytidine deaminases, nucleoside deaminases, deoxycytidylate deaminases and riboflavin deaminases. Also included are the apoBec family of mRNA editing enzymes. All members...; Region: cytidine_deaminase-like; cl00269 441771000389 active site 441771000390 Zn binding site [ion binding]; other site 441771000391 undecaprenyl-phosphate alpha-N-acetylglucosaminyl 1-phosphatetransferase; Region: ECA_wecA; TIGR02380 441771000392 This subfamily contains Escherichia coli WecA, Bacillus subtilis TagO and related proteins. WecA is an UDP-N-acetylglucosamine (GlcNAc):undecaprenyl-phosphate (Und-P) GlcNAc-1-phosphate transferase that catalyzes the formation of a phosphodiester bond...; Region: GT_WecA_like; cd06853 441771000393 Mg++ binding site [ion binding]; other site 441771000394 putative catalytic motif [active] 441771000395 substrate binding site [chemical binding]; other site 441771000396 UDP-N-acetylglucosamine 2-epimerase [Cell envelope biogenesis, outer membrane]; Region: WecB; COG0381 441771000397 Bacterial members of the UDP-N-Acetylglucosamine (GlcNAc) 2-Epimerase family are known to catalyze the reversible interconversion of UDP-GlcNAc and UDP-N-acetylmannosamine (UDP-ManNAc). The enzyme serves to produce an activated form of ManNAc residues; Region: GT1_UDP-GlcNAc_2-Epimerase; cd03786 441771000398 active site 441771000399 homodimer interface [polypeptide binding]; other site 441771000400 F0F1 ATP synthase subunit A; Validated; Region: PRK05815 441771000401 F0F1 ATP synthase subunit C; Provisional; Region: PRK13469 441771000402 F0F1 ATP synthase subunit B; Provisional; Region: PRK13461 441771000403 F0F1-type ATP synthase, subunit b [Energy production and conversion]; Region: AtpF; COG0711 441771000404 F0F1 ATP synthase subunit delta; Validated; Region: PRK05758 441771000405 F0F1 ATP synthase subunit alpha; Validated; Region: PRK09281 441771000406 ATP synthase alpha/beta family, beta-barrel domain; Region: ATP-synt_ab_N; pfam02874 441771000407 F1 ATP synthase alpha, central domain. The F-ATPase is found in bacterial plasma membranes, mitochondrial inner membranes and in chloroplast thylakoid membranes. It has also been found in the archaea Methanosarcina barkeri. It uses a proton gradient to...; Region: F1_ATPase_alpha; cd01132 441771000408 beta subunit interaction interface [polypeptide binding]; other site 441771000409 Walker A motif; other site 441771000410 ATP binding site [chemical binding]; other site 441771000411 Walker B motif; other site 441771000412 ATP synthase alpha/beta chain, C terminal domain; Region: ATP-synt_ab_C; pfam00306 441771000413 mitochondrial ATP synthase gamma subunit; Region: F1-ATPase_gamma; cd12151 441771000414 core domain interface [polypeptide binding]; other site 441771000415 delta subunit interface [polypeptide binding]; other site 441771000416 epsilon subunit interface [polypeptide binding]; other site 441771000417 F0F1 ATP synthase subunit beta; Validated; Region: PRK09280 441771000418 ATP synthase alpha/beta family, beta-barrel domain; Region: ATP-synt_ab_N; pfam02874 441771000419 F1 ATP synthase beta subunit, nucleotide-binding domain. The F-ATPase is found in bacterial plasma membranes, mitochondrial inner membranes and in chloroplast thylakoid membranes. It has also been found in the archaea Methanosarcina barkeri. It uses a...; Region: F1-ATPase_beta; cd01133 441771000420 alpha subunit interaction interface [polypeptide binding]; other site 441771000421 Walker A motif; other site 441771000422 ATP binding site [chemical binding]; other site 441771000423 Walker B motif; other site 441771000424 inhibitor binding site; inhibition site 441771000425 ATP synthase alpha/beta chain, C terminal domain; Region: ATP-synt_ab_C; pfam00306 441771000426 F0F1 ATP synthase subunit epsilon; Provisional; Region: atpC; PRK13450 441771000427 mitochondrial ATP synthase delta subunit; Region: F1-ATPase_delta; cd12152 441771000428 gamma subunit interface [polypeptide binding]; other site 441771000429 epsilon subunit interface [polypeptide binding]; other site 441771000430 LBP interface [polypeptide binding]; other site 441771000431 Protein of unknown function (DUF1779); Region: DUF1779; pfam08680 441771000432 EPSP synthase (3-phosphoshikimate 1-carboxyvinyltransferase); Region: EPSP_synthase; pfam00275 441771000433 UDP-N-acetylglucosamine enolpyruvyl transferase catalyzes enolpyruvyl transfer as part of the first step in the biosynthesis of peptidoglycan, a component of the bacterial cell wall. The reaction is phosphoenolpyruvate + UDP-N-acetyl-D-glucosamine =...; Region: UdpNAET; cd01555 441771000434 hinge; other site 441771000435 active site 441771000436 stage II sporulation protein D; Region: spore_II_D; TIGR02870 441771000437 Stage II sporulation protein; Region: SpoIID; pfam08486 441771000438 Membrane proteins related to metalloendopeptidases [Cell envelope biogenesis, outer membrane]; Region: NlpD; COG0739 441771000439 Peptidase family M23; Region: Peptidase_M23; pfam01551 441771000440 Stage III sporulation protein D; Region: SpoIIID; pfam12116 441771000441 rod shape-determining protein Mbl; Provisional; Region: PRK13928 441771000442 MreB and similar proteins; Region: MreB_like; cd10225 441771000443 nucleotide binding site [chemical binding]; other site 441771000444 Mg binding site [ion binding]; other site 441771000445 putative protofilament interaction site [polypeptide binding]; other site 441771000446 RodZ interaction site [polypeptide binding]; other site 441771000447 Protein of unknown function (DUF1256); Region: DUF1256; pfam06866 441771000448 tRNA 2-thiocytidine biosynthesis protein TtcA; Provisional; Region: PRK10696 441771000449 This is a subfamily of Adenine nucleotide alpha hydrolases superfamily.Adeninosine nucleotide alpha hydrolases superfamily includes N type ATP PPases and ATP sulphurylases. It forms a apha/beta/apha fold which binds to Adenosine group. This subfamily; Region: Alpha_ANH_like_II; cd01993 441771000450 Ligand Binding Site [chemical binding]; other site 441771000451 S-adenosylmethionine synthetase; Validated; Region: PRK05250 441771000452 S-adenosylmethionine synthetase, N-terminal domain; Region: S-AdoMet_synt_N; pfam00438 441771000453 S-adenosylmethionine synthetase, central domain; Region: S-AdoMet_synt_M; pfam02772 441771000454 S-adenosylmethionine synthetase, C-terminal domain; Region: S-AdoMet_synt_C; pfam02773 441771000455 helicase, putative, RecD/TraA family; Region: recD_rel; TIGR01448 441771000456 Helix-hairpin-helix domain; Region: HHH_5; pfam14520 441771000457 Helix-hairpin-helix containing domain; Region: HHH_4; pfam14490 441771000458 AAA domain; Region: AAA_30; pfam13604 441771000459 UvrD-like helicase C-terminal domain; Region: UvrD_C_2; pfam13538 441771000460 Superfamily II DNA/RNA helicase required for DNA uptake (late competence protein) [DNA replication, recombination, and repair]; Region: comFA; COG4098 441771000461 Predicted amidophosphoribosyltransferases [General function prediction only]; Region: ComFC; COG1040 441771000462 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 441771000463 active site 441771000464 RaiA ("ribosome-associated inhibitor A", also known as Protein Y (PY), YfiA, and SpotY, is a stress-response protein that binds the ribosomal subunit interface and arrests translation by interfering with aminoacyl-tRNA binding to the ribosomal...; Region: RaiA; cd00552 441771000465 30S subunit binding site; other site 441771000466 preprotein translocase subunit SecA; Reviewed; Region: PRK12904 441771000467 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 441771000468 ATP binding site [chemical binding]; other site 441771000469 putative Mg++ binding site [ion binding]; other site 441771000470 SecA preprotein cross-linking domain; Region: SecA_PP_bind; smart00958 441771000471 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 441771000472 nucleotide binding region [chemical binding]; other site 441771000473 ATP-binding site [chemical binding]; other site 441771000474 SecA Wing and Scaffold domain; Region: SecA_SW; pfam07516 441771000475 SEC-C motif; Region: SEC-C; pfam02810 441771000476 peptide chain release factor 2; Provisional; Region: PRK05589 441771000477 This domain is found in peptide chain release factors; Region: PCRF; smart00937 441771000478 RF-1 domain; Region: RF-1; pfam00472 441771000479 Predicted aminopeptidases [General function prediction only]; Region: Iap; COG2234 441771000480 M28 Zn-Peptidases containing a PA domain insert; Region: M28_like_PA; cd03877 441771000481 metal binding site [ion binding]; metal-binding site 441771000482 Transcriptional accessory protein [Transcription]; Region: Tex; COG2183 441771000483 Tex-like protein N-terminal domain; Region: Tex_N; pfam09371 441771000484 Likely ribonuclease with RNase H fold; Region: YqgFc; smart00732 441771000485 Helix-hairpin-helix motif; Region: HHH_3; pfam12836 441771000486 S1_Tex: The C-terminal S1 domain of a transcription accessory factor called Tex, which has been characterized in Bordetella pertussis and Pseudomonas aeruginosa. The tex gene is essential in Bortella pertusis and is named for its role in toxin expression; Region: S1_Tex; cd05685 441771000487 RNA binding site [nucleotide binding]; other site 441771000488 Predicted membrane protein [Function unknown]; Region: COG3601 441771000489 FlhB HrpN YscU SpaS Family; Region: Bac_export_2; cl19167 441771000490 Predicted phosphohydrolases [General function prediction only]; Region: Icc; COG1409 441771000491 metallophosphatase superfamily, metallophosphatase domain; Region: MPP_superfamily; cl13995 441771000492 active site 441771000493 metal binding site [ion binding]; metal-binding site 441771000494 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 441771000495 dimerization interface [polypeptide binding]; other site 441771000496 putative DNA binding site [nucleotide binding]; other site 441771000497 putative Zn2+ binding site [ion binding]; other site 441771000498 CoA-disulfide reductase; Region: CoA_CoA_reduc; TIGR03385 441771000499 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 441771000500 Pyridine nucleotide-disulphide oxidoreductase, dimerization domain; Region: Pyr_redox_dim; pfam02852 441771000501 Member of the Rhodanese Homology Domain superfamily. Included in this CD are the Lactococcus lactis NADH oxidase, Bacillus cereus NADH dehydrogenase, and Bacteroides thetaiotaomicron pyridine nucleotide-disulphide oxidoreductase, and similar...; Region: RHOD_Pyr_redox; cd01524 441771000502 active site residue [active] 441771000503 SirA, YedF, and YeeD. Two-layered alpha/beta sandwich domain. SirA (also known as UvrY, and YhhP) belongs to a family of bacterial two-component response regulators that controls secondary metabolism and virulence. The other member of this...; Region: SirA_YedF_YeeD; cl00436 441771000504 CPxP motif; other site 441771000505 DsrE/DsrF/DrsH-like family; Region: DrsE_2; pfam13686 441771000506 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG1655 441771000507 Uncharacterized protein conserved in bacteria (DUF2225); Region: DUF2225; pfam09986 441771000508 Nucleotidyltransferase (NT) domain of RelA- and SpoT-like ppGpp synthetases and hydrolases; Region: NT_Rel-Spo_like; cd05399 441771000509 synthetase active site [active] 441771000510 NTP binding site [chemical binding]; other site 441771000511 metal binding site [ion binding]; metal-binding site 441771000512 leucyl-tRNA synthetase; Validated; Region: leuS; PRK00390 441771000513 catalytic core domain of leucyl-tRNA synthetases; Region: LeuRS_core; cd00812 441771000514 active site 441771000515 HIGH motif; other site 441771000516 Leucyl-tRNA synthetase, Domain 2; Region: tRNA-synt_1_2; pfam13603 441771000517 KMSKS motif; other site 441771000518 Anticodon-binding domain of bacterial and eukaryotic mitochondrial leucyl tRNA synthetases; Region: Anticodon_Ia_Leu_BEm; cd07958 441771000519 tRNA binding surface [nucleotide binding]; other site 441771000520 Rhodanese Homology Domain (RHOD); an alpha beta fold domain found duplicated in the rhodanese protein. The cysteine containing enzymatically active version of the domain is also found in the Cdc25 class of protein phosphatases and a variety of proteins...; Region: RHOD; cd00158 441771000521 active site residue [active] 441771000522 DnaJ domain or J-domain. DnaJ/Hsp40 (heat shock protein 40) proteins are highly conserved and play crucial roles in protein translation, folding, unfolding, translocation, and degradation. They act primarily by stimulating the ATPase activity of Hsp70s; Region: DnaJ; cd06257 441771000523 DnaJ-class molecular chaperone with C-terminal Zn finger domain [Posttranslational modification, protein turnover, chaperones]; Region: DnaJ; COG0484 441771000524 HSP70 interaction site [polypeptide binding]; other site 441771000525 Adenylyl cyclase (AC) class IV-like, a subgroup of the CYTH-like superfamily; Region: CYTH-like_AC_IV-like; cd07890 441771000526 putative active site [active] 441771000527 putative triphosphate binding site [ion binding]; other site 441771000528 signature motif; other site 441771000529 dimer interface [polypeptide binding]; other site 441771000530 37-kD nucleoid-associated bacterial protein; Region: NA37; pfam04245 441771000531 Tagatose-1,6-bisphosphate (TBP) aldolase and related Type B Class II aldolases. TBP aldolase is a tetrameric class II aldolase that catalyzes the reversible condensation of dihydroxyacetone phosphate with glyceraldehyde 3-phsophate to produce tagatose 1; Region: TBP_aldolase_IIB; cd00947 441771000532 intersubunit interface [polypeptide binding]; other site 441771000533 active site 441771000534 zinc binding site [ion binding]; other site 441771000535 Na+ binding site [ion binding]; other site 441771000536 Domain of unknown function (DUF4363); Region: DUF4363; pfam14276 441771000537 Predicted membrane protein [Function unknown]; Region: COG2323 441771000538 Uridine monophosphate kinase_like (UMPK_like) is a family of proteins highly similar to the uridine monophosphate kinase (UMPK, EC 2.7.1.48), also known as uridine kinase or uridine-cytidine kinase (UCK); Region: UMPK_like; cd02028 441771000539 active site 441771000540 CDP-alcohol phosphatidyltransferase; Region: CDP-OH_P_transf; cl00453 441771000541 FOG: CBS domain [General function prediction only]; Region: COG0517 441771000542 The CBS domain, named after human CBS, is a small domain originally identified in cystathionine beta-synthase and is subsequently found in a wide range of different proteins. CBS domains usually occur in tandem repeats. They associate to form a so-called...; Region: CBS_pair_9; cd04622 441771000543 putative lipid kinase; Reviewed; Region: PRK13059 441771000544 Diacylglycerol kinase catalytic domain; Region: DAGK_cat; pfam00781 441771000545 Radical SAM N-terminal; Region: Radical_SAM_N; pfam08497 441771000546 hypothetical protein; Provisional; Region: PRK00955 441771000547 Elongator protein 3, MiaB family, Radical SAM; Region: Elp3; smart00729 441771000548 Domain of unknown function (DUF3362); Region: DUF3362; pfam11842 441771000549 PRC-barrel domain; Region: PRC; pfam05239 441771000550 MgtE intracellular N domain; Region: MgtE_N; smart00924 441771000551 FOG: CBS domain [General function prediction only]; Region: COG0517 441771000552 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domain in the magnesium transporter, MgtE. MgtE and its homologs are found in eubacteria, archaebacteria, and eukaryota. Members of this family transport Mg2+ or other...; Region: CBS_pair_Mg_transporter; cd04606 441771000553 spore cortex-lytic enzyme; Region: spore_SleB; TIGR02869 441771000554 Putative peptidoglycan binding domain; Region: PG_binding_1; pfam01471 441771000555 Cell Wall Hydrolase; Region: Hydrolase_2; pfam07486 441771000556 cysteine synthase; Region: PLN02565 441771000557 CBS_like: This subgroup includes Cystathionine beta-synthase (CBS) and Cysteine synthase. CBS is a unique heme-containing enzyme that catalyzes a pyridoxal 5'-phosphate (PLP)-dependent condensation of serine and homocysteine to give cystathionine; Region: CBS_like; cd01561 441771000558 dimer interface [polypeptide binding]; other site 441771000559 pyridoxal 5'-phosphate binding site [chemical binding]; other site 441771000560 catalytic residue [active] 441771000561 Serine acetyltransferase [Amino acid transport and metabolism]; Region: CysE; COG1045 441771000562 Serine acetyltransferase (SAT): SAT catalyzes the CoA-dependent acetylation of the side chain hydroxyl group of L-serine to form O-acetylserine, as the first step of a two-step biosynthetic pathway in bacteria and plants leading to the formation of...; Region: LbH_SAT; cd03354 441771000563 trimer interface [polypeptide binding]; other site 441771000564 active site 441771000565 substrate binding site [chemical binding]; other site 441771000566 CoA binding site [chemical binding]; other site 441771000567 Uncharacterized Fe-S protein [Energy production and conversion]; Region: COG1600 441771000568 Domain of unknown function (DUF1730); Region: DUF1730; pfam08331 441771000569 4Fe-4S double cluster binding domain; Region: Fer4_16; pfam13484 441771000570 Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: AGPAT-like; Region: LPLAT_AGPAT-like; cd07989 441771000571 putative acyl-acceptor binding pocket; other site 441771000572 Predicted EndoIII-related endonuclease [DNA replication, recombination, and repair]; Region: Nth; COG0177 441771000573 endonuclease III; includes endonuclease III (DNA-(apurinic or apyrimidinic site) lyase), alkylbase DNA glycosidases (Alka-family) and other DNA glycosidases; Region: ENDO3c; cd00056 441771000574 minor groove reading motif; other site 441771000575 helix-hairpin-helix signature motif; other site 441771000576 substrate binding pocket [chemical binding]; other site 441771000577 active site 441771000578 iron-sulpphur binding domain in DNA-(apurinic or apyrimidinic site) lyase (subfamily of ENDO3); Region: FES; smart00525 441771000579 Malic enzyme [Energy production and conversion]; Region: SfcA; COG0281 441771000580 Malic enzyme, N-terminal domain; Region: malic; pfam00390 441771000581 NAD(P) binding domain of malic enzyme (ME), subgroup 2; Region: NAD_bind_2_malic_enz; cd05311 441771000582 putative NAD(P) binding site [chemical binding]; other site 441771000583 competence damage-inducible protein A; Provisional; Region: PRK00549 441771000584 Competence-damaged protein. CinA is the first gene in the competence- inducible (cin) operon and is thought to be specifically required at some stage in the process of transformation. This domain is closely related to a domain, found in a variety of...; Region: cinA; cd00885 441771000585 putative MPT binding site; other site 441771000586 Competence-damaged protein; Region: CinA; pfam02464 441771000587 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 441771000588 Putative lysophospholipase; Region: Hydrolase_4; cl19140 441771000589 Serine hydrolase (FSH1); Region: FSH1; pfam03959 441771000590 M42 Peptidase, Endoglucanase-like subfamily; Region: M42_glucanase_like; cd05657 441771000591 putative oligomer interface [polypeptide binding]; other site 441771000592 putative active site [active] 441771000593 metal binding site [ion binding]; metal-binding site 441771000594 Putative peptidoglycan binding domain; Region: PG_binding_4; pfam12229 441771000595 VanW like protein; Region: VanW; pfam04294 441771000596 Uncharacterized vancomycin resistance protein [Defense mechanisms]; Region: COG2720 441771000597 Putative peptidoglycan binding domain; Region: PG_binding_4; pfam12229 441771000598 VanW like protein; Region: VanW; pfam04294 441771000599 G5 domain; Region: G5; pfam07501 441771000600 DNA repair photolyase [DNA replication, recombination, and repair]; Region: SplB; COG1533 441771000601 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 441771000602 FeS/SAM binding site; other site 441771000603 Predicted rRNA methylase (SpoU class) [Translation, ribosomal structure and biogenesis]; Region: CspR; COG0219 441771000604 EDD domain protein, DegV family; Region: DegV; TIGR00762 441771000605 Periplasmic binding domain of basic membrane lipoprotein, PnrA, in Treponema pallidum and its homologs from other bacteria and Archaea; Region: PBP1_BmpA_PnrA_like; cd06354 441771000606 ligand binding site [chemical binding]; other site 441771000607 ABC-type uncharacterized transport systems, ATPase components [General function prediction only]; Region: COG3845 441771000608 First domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_I; cd03216 441771000609 Walker A/P-loop; other site 441771000610 ATP binding site [chemical binding]; other site 441771000611 Q-loop/lid; other site 441771000612 ABC transporter signature motif; other site 441771000613 Walker B; other site 441771000614 D-loop; other site 441771000615 H-loop/switch region; other site 441771000616 Second domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_II; cd03215 441771000617 Transmembrane subunit (TM) of Treponema pallidum (Tp) RbsC-1, RbsC-2 and related proteins. This is a functionally uncharacterized subgroup of TMs which belong to a larger group of TMs of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette; Region: TM_PBP1_transp_TpRbsC_like; cd06580 441771000618 TM-ABC transporter signature motif; other site 441771000619 Transmembrane subunit (TM) of Treponema pallidum (Tp) RbsC-1, RbsC-2 and related proteins. This is a functionally uncharacterized subgroup of TMs which belong to a larger group of TMs of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette; Region: TM_PBP1_transp_TpRbsC_like; cd06580 441771000620 TM-ABC transporter signature motif; other site 441771000621 Predicted xylanase/chitin deacetylase [Carbohydrate transport and metabolism]; Region: CDA1; COG0726 441771000622 Catalytic NodB homology domain of Streptococcus mutans polysaccharide deacetylase PgdA, Bacillus subtilis YheN, and similar proteins; Region: CE4_SmPgdA_like; cd10944 441771000623 NodB motif; other site 441771000624 active site 441771000625 catalytic site [active] 441771000626 Zn binding site [ion binding]; other site 441771000627 RNA polymerase factor sigma-54; Reviewed; Region: PRK05932 441771000628 Sigma-54 factor, Activator interacting domain (AID); Region: Sigma54_AID; pfam00309 441771000629 Sigma-54 factor, core binding domain; Region: Sigma54_CBD; pfam04963 441771000630 Sigma-54, DNA binding domain; Region: Sigma54_DBD; pfam04552 441771000631 Transcriptional regulator, contains sigma factor-related N-terminal domain [Transcription]; Region: DeoR; COG2390 441771000632 Putative sugar-binding domain; Region: Sugar-bind; pfam04198 441771000633 Glyceraldehyde-3-phosphate dehydrogenase/erythrose-4-phosphate dehydrogenase [Carbohydrate transport and metabolism]; Region: GapA; COG0057 441771000634 Glyceraldehyde 3-phosphate dehydrogenase, NAD binding domain; Region: Gp_dh_N; smart00846 441771000635 Glyceraldehyde 3-phosphate dehydrogenase, C-terminal domain; Region: Gp_dh_C; pfam02800 441771000636 Phosphoglycerate kinase (PGK) is a monomeric enzyme which catalyzes the transfer of the high-energy phosphate group of 1,3-bisphosphoglycerate to ADP, forming ATP and 3-phosphoglycerate. This reaction represents the first of the two substrate-level...; Region: Phosphoglycerate_kinase; cd00318 441771000637 substrate binding site [chemical binding]; other site 441771000638 hinge regions; other site 441771000639 ADP binding site [chemical binding]; other site 441771000640 catalytic site [active] 441771000641 Triosephosphate isomerase (TIM) is a glycolytic enzyme that catalyzes the interconversion of dihydroxyacetone phosphate and D-glyceraldehyde-3-phosphate. The reaction is very efficient and requires neither cofactors nor metal ions. TIM, usually...; Region: TIM; cd00311 441771000642 substrate binding site [chemical binding]; other site 441771000643 dimer interface [polypeptide binding]; other site 441771000644 catalytic triad [active] 441771000645 phosphoglyceromutase; Provisional; Region: PRK05434 441771000646 enolase; Provisional; Region: eno; PRK00077 441771000647 Enolase: Enolases are homodimeric enzymes that catalyse the reversible dehydration of 2-phospho-D-glycerate to phosphoenolpyruvate as part of the glycolytic and gluconeogenesis pathways. The reaction is facilitated by the presence of metal ions; Region: enolase; cd03313 441771000648 dimer interface [polypeptide binding]; other site 441771000649 metal binding site [ion binding]; metal-binding site 441771000650 substrate binding pocket [chemical binding]; other site 441771000651 protein translocase, SecG subunit; Region: secG; TIGR00810 441771000652 ribonuclease R; Region: RNase_R; TIGR02063 441771000653 Ribonuclease B OB domain; Region: OB_RNB; pfam08206 441771000654 Ribonuclease B OB domain; Region: OB_RNB; pfam08206 441771000655 RNB domain; Region: RNB; pfam00773 441771000656 S1_RNase_R: RNase R C-terminal S1 domain. RNase R is a processive 3' to 5' exoribonuclease, which is a homolog of RNase II. RNase R degrades RNA with secondary structure having a 3' overhang of at least 7 nucleotides. RNase R and PNPase...; Region: S1_RNase_R; cd04471 441771000657 RNA binding site [nucleotide binding]; other site 441771000658 stationary phase survival protein SurE; Provisional; Region: PRK13933 441771000659 Small protein B (SmpB) is a component of the trans-translation system in prokaryotes for releasing stalled ribosome from damaged messenger RNAs; Region: SmpB; cd09294 441771000660 SmpB-tmRNA interface; other site 441771000661 Sodium:dicarboxylate symporter family; Region: SDF; pfam00375 441771000662 FAD/FMN-containing dehydrogenases [Energy production and conversion]; Region: GlcD; COG0277 441771000663 FAD binding domain; Region: FAD_binding_4; pfam01565 441771000664 Berberine and berberine like; Region: BBE; pfam08031 441771000665 Glutamate decarboxylase and related PLP-dependent proteins [Amino acid transport and metabolism]; Region: GadB; COG0076 441771000666 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 441771000667 catalytic residue [active] 441771000668 flagellin; Provisional; Region: PRK12804 441771000669 Bacterial flagellin N-terminal helical region; Region: Flagellin_N; pfam00669 441771000670 Bacterial flagellin C-terminal helical region; Region: Flagellin_C; pfam00700 441771000671 PAP2, haloperoxidase_like subfamily. Haloperoxidases catalyze the oxidation of halides such as bromide or chloride by hydrogen peroxide, which results in subsequent halogenation of organic substrates, or halide-assisted disproportionation of hydrogen...; Region: PAP2_haloperoxidase; cd03398 441771000672 active site 441771000673 Mannose-6-phosphate isomerase [Carbohydrate transport and metabolism]; Region: {ManC}; COG0662 441771000674 Rhoptry-associated protein 1 (RAP-1); Region: RAP1; pfam07218 441771000675 Malic enzyme [Energy production and conversion]; Region: SfcA; COG0281 441771000676 Malic enzyme, N-terminal domain; Region: malic; pfam00390 441771000677 NAD(P) binding domain of malic enzyme (ME), subgroup 2; Region: NAD_bind_2_malic_enz; cd05311 441771000678 putative NAD(P) binding site [chemical binding]; other site 441771000679 2-keto-3-deoxygluconate permease; Provisional; Region: PRK05274 441771000680 Signal transduction histidine kinase regulating citrate/malate metabolism [Signal transduction mechanisms]; Region: CitA; COG3290 441771000681 Sensory domain of two-component sensor kinase; Region: Cache_3; pfam14827 441771000682 PAS domain; Region: PAS; smart00091 441771000683 Sensor_kinase_SpoOB-type, alpha-helical domain; Region: SPOB_a; pfam14689 441771000684 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 441771000685 ATP binding site [chemical binding]; other site 441771000686 Mg2+ binding site [ion binding]; other site 441771000687 G-X-G motif; other site 441771000688 Response regulator of citrate/malate metabolism [Transcription / Signal transduction mechanisms]; Region: CitB; COG4565 441771000689 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 441771000690 active site 441771000691 phosphorylation site [posttranslational modification] 441771000692 intermolecular recognition site; other site 441771000693 dimerization interface [polypeptide binding]; other site 441771000694 HTH domain; Region: HTH_11; cl17392 441771000695 lysine transporter; Provisional; Region: PRK10836 441771000696 AbgT putative transporter family; Region: ABG_transport; cl17431 441771000697 Transmembrane amino acid transporter protein; Region: Aa_trans; cl17468 441771000698 Metallo-beta-lactamase superfamily; Region: Lactamase_B; smart00849 441771000699 Acetyltransferase (GNAT) family; Region: Acetyltransf_1; pfam00583 441771000700 Cytidine deaminase [Nucleotide transport and metabolism]; Region: Cdd; COG0295 441771000701 Cytidine deaminase zinc-binding domain. These enzymes are Zn dependent. The zinc ion in the active site plays a central role in the proposed catalytic mechanism, activating a water molecule to form a hydroxide ion that performs a nucleophilic attack on...; Region: cytidine_deaminase; cd01283 441771000702 active site 441771000703 catalytic motif [active] 441771000704 Zn binding site [ion binding]; other site 441771000705 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 441771000706 Coenzyme A binding pocket [chemical binding]; other site 441771000707 Dihydrofolate reductase (DHFR). Reduces 7,8-dihydrofolate to 5,6,7,8-tetrahydrofolate with NADPH as a cofactor. This is an essential step in the biosynthesis of deoxythymidine phosphate since 5,6,7,8-tetrahydrofolate is required to regenerate 5; Region: DHFR; cl17426 441771000708 DNA polymerase III subunit epsilon; Validated; Region: PRK06195 441771000709 an uncharacterized bacterial subgroup of the DEDDh 3'-5' exonuclease domain family with similarity to the epsilon subunit of DNA polymerase III; Region: DNA_pol_III_epsilon_like; cd06130 441771000710 active site 441771000711 catalytic site [active] 441771000712 substrate binding site [chemical binding]; other site 441771000713 Breast Cancer Suppressor Protein (BRCA1), carboxy-terminal domain. The BRCT domain is found within many DNA damage repair and cell cycle checkpoint proteins. The unique diversity of this domain superfamily allows BRCT modules to interact forming homo...; Region: BRCT; cd00027 441771000714 Dimer interface [polypeptide binding]; other site 441771000715 BRCT sequence motif; other site 441771000716 Cysteine hydrolases; This family contains amidohydrolases, like CSHase (N-carbamoylsarcosine amidohydrolase), involved in creatine metabolism and nicotinamidase, converting nicotinamide to nicotinic acid and ammonia in the pyridine nucleotide cycle. It...; Region: cysteine_hydrolases; cd00431 441771000717 catalytic triad [active] 441771000718 conserved cis-peptide bond; other site 441771000719 Aerobic-type carbon monoxide dehydrogenase, large subunit CoxL/CutL homologs [Energy production and conversion]; Region: CoxL; COG1529 441771000720 Aldehyde oxidase and xanthine dehydrogenase, a/b hammerhead domain; Region: Ald_Xan_dh_C; smart01008 441771000721 Molybdopterin-binding domain of aldehyde dehydrogenase; Region: Ald_Xan_dh_C2; pfam02738 441771000722 Aerobic-type carbon monoxide dehydrogenase, middle subunit CoxM/CutM homologs [Energy production and conversion]; Region: CoxM; COG1319 441771000723 FAD binding domain; Region: FAD_binding_4; cl19922 441771000724 CO dehydrogenase flavoprotein C-terminal domain; Region: CO_deh_flav_C; smart01092 441771000725 Aerobic-type carbon monoxide dehydrogenase, small subunit CoxS/CutS homologs [Energy production and conversion]; Region: CoxS; COG2080 441771000726 2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207 441771000727 catalytic loop [active] 441771000728 iron binding site [ion binding]; other site 441771000729 [2Fe-2S] binding domain; Region: Fer2_2; pfam01799 441771000730 TlpA-like family; composed of TlpA, ResA, DsbE and similar proteins. TlpA, ResA and DsbE are bacterial protein disulfide reductases with important roles in cytochrome maturation. They are membrane-anchored proteins with a soluble TRX domain containing a...; Region: TlpA_like_family; cd02966 441771000731 catalytic residues [active] 441771000732 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 441771000733 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 441771000734 active site 441771000735 phosphorylation site [posttranslational modification] 441771000736 intermolecular recognition site; other site 441771000737 dimerization interface [polypeptide binding]; other site 441771000738 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 441771000739 DNA binding site [nucleotide binding] 441771000740 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 441771000741 HAMP domain; Region: HAMP; pfam00672 441771000742 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 441771000743 dimer interface [polypeptide binding]; other site 441771000744 phosphorylation site [posttranslational modification] 441771000745 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 441771000746 ATP binding site [chemical binding]; other site 441771000747 Mg2+ binding site [ion binding]; other site 441771000748 G-X-G motif; other site 441771000749 Alpha-galactosidases/6-phospho-beta-glucosidases, family 4 of glycosyl hydrolases [Carbohydrate transport and metabolism]; Region: CelF; COG1486 441771000750 Glycoside Hydrolases Family 4; GlvA- and pagL-like glycosidases; Region: GH4_GlvA_pagL_like; cd05298 441771000751 NAD binding site [chemical binding]; other site 441771000752 sugar binding site [chemical binding]; other site 441771000753 divalent metal binding site [ion binding]; other site 441771000754 putative tetramer (dimer of dimers) interface [polypeptide binding]; other site 441771000755 dimer interface [polypeptide binding]; other site 441771000756 bifunctional PTS system maltose and glucose-specific transporter subunits IICB; Provisional; Region: PRK10110 441771000757 Phosphotransferase system IIC components, glucose/maltose/N-acetylglucosamine-specific [Carbohydrate transport and metabolism]; Region: PtsG; COG1263 441771000758 PTS_IIB, PTS system, glucose/sucrose specific IIB subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIB_glc; cd00212 441771000759 active site turn [active] 441771000760 phosphorylation site [posttranslational modification] 441771000761 Transcriptional regulators [Transcription]; Region: RpiR; COG1737 441771000762 Helix-turn-helix domain, rpiR family; Region: HTH_6; pfam01418 441771000763 RpiR-like protein. RpiR contains a SIS (Sugar ISomerase) domain, which is found in many phosphosugar isomerases and phosphosugar binding proteins. In E. coli, rpiR negatively regulates the expression of rpiB gene. Both rpiB and rpiA are ribose phosphate...; Region: SIS_RpiR; cd05013 441771000764 putative active site [active] 441771000765 Transcriptional regulators [Transcription]; Region: RpiR; COG1737 441771000766 Helix-turn-helix domain, rpiR family; Region: HTH_6; pfam01418 441771000767 RpiR-like protein. RpiR contains a SIS (Sugar ISomerase) domain, which is found in many phosphosugar isomerases and phosphosugar binding proteins. In E. coli, rpiR negatively regulates the expression of rpiB gene. Both rpiB and rpiA are ribose phosphate...; Region: SIS_RpiR; cd05013 441771000768 putative active site [active] 441771000769 Phosphotransferase system IIA components [Carbohydrate transport and metabolism]; Region: NagE; COG2190 441771000770 HPr interaction site; other site 441771000771 glycerol kinase (GK) interaction site [polypeptide binding]; other site 441771000772 active site 441771000773 phosphorylation site [posttranslational modification] 441771000774 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 441771000775 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 441771000776 active site 441771000777 phosphorylation site [posttranslational modification] 441771000778 intermolecular recognition site; other site 441771000779 dimerization interface [polypeptide binding]; other site 441771000780 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 441771000781 DNA binding site [nucleotide binding] 441771000782 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 441771000783 His Kinase A (phosphoacceptor) domain; Region: HisKA; smart00388 441771000784 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 441771000785 ATP binding site [chemical binding]; other site 441771000786 Mg2+ binding site [ion binding]; other site 441771000787 G-X-G motif; other site 441771000788 ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136 441771000789 ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255 441771000790 Walker A/P-loop; other site 441771000791 ATP binding site [chemical binding]; other site 441771000792 Q-loop/lid; other site 441771000793 ABC transporter signature motif; other site 441771000794 Walker B; other site 441771000795 D-loop; other site 441771000796 H-loop/switch region; other site 441771000797 FtsX-like permease family; Region: FtsX; pfam02687 441771000798 alanine racemase; Reviewed; Region: alr; PRK00053 441771000799 Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzyme Alanine Racemase; Region: PLPDE_III_AR; cd00430 441771000800 active site 441771000801 pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site 441771000802 dimer interface [polypeptide binding]; other site 441771000803 substrate binding site [chemical binding]; other site 441771000804 catalytic residues [active] 441771000805 PTS system, alpha-glucoside-specific IIBC component; Region: PTS-IIBC-alpha; TIGR02005 441771000806 Phosphotransferase system IIC components, glucose/maltose/N-acetylglucosamine-specific [Carbohydrate transport and metabolism]; Region: PtsG; COG1263 441771000807 PTS_IIB, PTS system, glucose/sucrose specific IIB subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIB_glc; cd00212 441771000808 active site turn [active] 441771000809 phosphorylation site [posttranslational modification] 441771000810 Alpha-galactosidases/6-phospho-beta-glucosidases, family 4 of glycosyl hydrolases [Carbohydrate transport and metabolism]; Region: CelF; COG1486 441771000811 Glycoside Hydrolases Family 4; GlvA- and pagL-like glycosidases; Region: GH4_GlvA_pagL_like; cd05298 441771000812 NAD binding site [chemical binding]; other site 441771000813 sugar binding site [chemical binding]; other site 441771000814 divalent metal binding site [ion binding]; other site 441771000815 putative tetramer (dimer of dimers) interface [polypeptide binding]; other site 441771000816 dimer interface [polypeptide binding]; other site 441771000817 Phosphotransferase system IIA components [Carbohydrate transport and metabolism]; Region: NagE; COG2190 441771000818 HPr interaction site; other site 441771000819 glycerol kinase (GK) interaction site [polypeptide binding]; other site 441771000820 active site 441771000821 phosphorylation site [posttranslational modification] 441771000822 Transcriptional regulators [Transcription]; Region: RpiR; COG1737 441771000823 Helix-turn-helix domain, rpiR family; Region: HTH_6; pfam01418 441771000824 RpiR-like protein. RpiR contains a SIS (Sugar ISomerase) domain, which is found in many phosphosugar isomerases and phosphosugar binding proteins. In E. coli, rpiR negatively regulates the expression of rpiB gene. Both rpiB and rpiA are ribose phosphate...; Region: SIS_RpiR; cd05013 441771000825 putative active site [active] 441771000826 Cold-Shock Protein (CSP) contains an S1-like cold-shock domain (CSD) that is found in eukaryotes, prokaryotes, and archaea. CSP's include the major cold-shock proteins CspA and CspB in bacteria and the eukaryotic gene regulatory factor Y-box...; Region: CSP_CDS; cd04458 441771000827 DNA-binding site [nucleotide binding]; DNA binding site 441771000828 RNA-binding motif; other site 441771000829 Protein of unknown function (DUF1003); Region: DUF1003; pfam06210 441771000830 Predicted transcriptional regulator [Transcription]; Region: COG1959 441771000831 Rrf2 family protein; Region: rrf2_super; TIGR00738 441771000832 Predicted dithiol-disulfide isomerase involved in polyketide biosynthesis [Secondary metabolites biosynthesis, transport, and catabolism]; Region: FrnE; COG2761 441771000833 Nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: WcaG; COG0451 441771000834 biliverdin IX beta reductase (BVR-B, aka flavin reductase)-like proteins; atypical (a) SDRs; Region: BVR-B_like_SDR_a; cd05244 441771000835 NAD binding site [chemical binding]; other site 441771000836 substrate binding site [chemical binding]; other site 441771000837 putative active site [active] 441771000838 Transcriptional regulators [Transcription]; Region: RpiR; COG1737 441771000839 Helix-turn-helix domain, rpiR family; Region: HTH_6; pfam01418 441771000840 RpiR-like protein. RpiR contains a SIS (Sugar ISomerase) domain, which is found in many phosphosugar isomerases and phosphosugar binding proteins. In E. coli, rpiR negatively regulates the expression of rpiB gene. Both rpiB and rpiA are ribose phosphate...; Region: SIS_RpiR; cd05013 441771000841 putative active site [active] 441771000842 bifunctional PTS system maltose and glucose-specific transporter subunits IICB; Provisional; Region: PRK10110 441771000843 Phosphotransferase system IIC components, glucose/maltose/N-acetylglucosamine-specific [Carbohydrate transport and metabolism]; Region: PtsG; COG1263 441771000844 PTS_IIB, PTS system, glucose/sucrose specific IIB subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIB_glc; cd00212 441771000845 active site turn [active] 441771000846 phosphorylation site [posttranslational modification] 441771000847 Alpha-galactosidases/6-phospho-beta-glucosidases, family 4 of glycosyl hydrolases [Carbohydrate transport and metabolism]; Region: CelF; COG1486 441771000848 Glycoside Hydrolases Family 4; GlvA- and pagL-like glycosidases; Region: GH4_GlvA_pagL_like; cd05298 441771000849 NAD binding site [chemical binding]; other site 441771000850 sugar binding site [chemical binding]; other site 441771000851 divalent metal binding site [ion binding]; other site 441771000852 putative tetramer (dimer of dimers) interface [polypeptide binding]; other site 441771000853 dimer interface [polypeptide binding]; other site 441771000854 Phosphotransferase system IIA components [Carbohydrate transport and metabolism]; Region: NagE; COG2190 441771000855 HPr interaction site; other site 441771000856 glycerol kinase (GK) interaction site [polypeptide binding]; other site 441771000857 active site 441771000858 phosphorylation site [posttranslational modification] 441771000859 Dehydratase family; Region: ILVD_EDD; pfam00920 441771000860 Entner-Doudoroff aldolase; Region: eda; TIGR01182 441771000861 KDPG and KHG aldolase; Region: KDPG_aldolase; cd00452 441771000862 active site 441771000863 intersubunit interface [polypeptide binding]; other site 441771000864 catalytic residue [active] 441771000865 2-keto-3-deoxygluconate kinase (KdgK) phosphorylates 2-keto-3-deoxygluconate (KDG) to form 2-keto-3-deoxy-6-phosphogluconate (KDGP). KDG is the common intermediate product, that allows organisms to channel D-glucuronate and/or D-galacturinate into the...; Region: KdgK; cd01166 441771000866 substrate binding site [chemical binding]; other site 441771000867 ATP binding site [chemical binding]; other site 441771000868 Adenine deaminase [Nucleotide transport and metabolism]; Region: AdeC; COG1001 441771000869 Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281 441771000870 Adenine deaminase (AdeC) directly deaminates adenine to form hypoxanthine. This reaction is part of one of the adenine salvage pathways, as well as the degradation pathway. It is important for adenine utilization as a purine, as well as a nitrogen source...; Region: AdeC; cd01295 441771000871 active site 441771000872 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 441771000873 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 441771000874 active site 441771000875 phosphorylation site [posttranslational modification] 441771000876 intermolecular recognition site; other site 441771000877 dimerization interface [polypeptide binding]; other site 441771000878 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 441771000879 DNA binding site [nucleotide binding] 441771000880 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 441771000881 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 441771000882 dimerization interface [polypeptide binding]; other site 441771000883 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 441771000884 dimer interface [polypeptide binding]; other site 441771000885 phosphorylation site [posttranslational modification] 441771000886 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 441771000887 ATP binding site [chemical binding]; other site 441771000888 Mg2+ binding site [ion binding]; other site 441771000889 G-X-G motif; other site 441771000890 undecaprenyl phosphate 4-deoxy-4-formamido-L-arabinose transferase; Provisional; Region: PRK10714 441771000891 Bacterial DPM1_like enzymes are related to eukaryotic DPM1; Region: DPM1_like_bac; cd04187 441771000892 Ligand binding site; other site 441771000893 Putative Catalytic site; other site 441771000894 DXD motif; other site 441771000895 GtrA-like protein; Region: GtrA; pfam04138 441771000896 4-amino-4-deoxy-L-arabinose transferase and related glycosyltransferases of PMT family [Cell envelope biogenesis, outer membrane]; Region: ArnT; COG1807 441771000897 Dolichyl-phosphate-mannose-protein mannosyltransferase; Region: PMT_2; pfam13231 441771000898 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 441771000899 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 441771000900 ABC-type Fe3+-hydroxamate transport system, periplasmic component [Inorganic ion transport and metabolism]; Region: FepB; COG0614 441771000901 Helical backbone metal receptor (TroA-like domain). These proteins have been shown to function in the ABC transport of ferric siderophores and metal ions such as Mn2+, Fe3+, Cu2+ and/or Zn2+. Their ligand binding site is formed in the interface between...; Region: TroA-like; cl00262 441771000902 intersubunit interface [polypeptide binding]; other site 441771000903 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550 441771000904 ABC-ATPase subunit interface; other site 441771000905 dimer interface [polypeptide binding]; other site 441771000906 putative PBP binding regions; other site 441771000907 ABC-type cobalamin/Fe3+-siderophores transport systems, ATPase components [Inorganic ion transport and metabolism / Coenzyme metabolism]; Region: FepC; COG1120 441771000908 ATP-binding component of iron-siderophores, vitamin B12 and hemin transporters and related proteins; Region: ABC_Iron-Siderophores_B12_Hemin; cd03214 441771000909 Walker A/P-loop; other site 441771000910 ATP binding site [chemical binding]; other site 441771000911 Q-loop/lid; other site 441771000912 ABC transporter signature motif; other site 441771000913 Walker B; other site 441771000914 D-loop; other site 441771000915 H-loop/switch region; other site 441771000916 Subfamily of the multidrug and toxic compound extrusion (MATE)-like proteins similar to Bacillus subtilis yoeA; Region: MATE_yoeA_like; cd13138 441771000917 Na+-driven multidrug efflux pump [Defense mechanisms]; Region: NorM; COG0534 441771000918 AraC-type DNA-binding domain-containing proteins [Transcription]; Region: AraC; COG2207 441771000919 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 441771000920 ABC-type Fe3+-hydroxamate transport system, periplasmic component [Inorganic ion transport and metabolism]; Region: FepB; COG0614 441771000921 Helical backbone metal receptor (TroA-like domain). These proteins have been shown to function in the ABC transport of ferric siderophores and metal ions such as Mn2+, Fe3+, Cu2+ and/or Zn2+. Their ligand binding site is formed in the interface between...; Region: TroA-like; cl00262 441771000922 intersubunit interface [polypeptide binding]; other site 441771000923 AraC-type DNA-binding domain-containing proteins [Transcription]; Region: AraC; COG2207 441771000924 ABC-type Fe3+-hydroxamate transport system, periplasmic component [Inorganic ion transport and metabolism]; Region: FepB; COG0614 441771000925 Helical backbone metal receptor (TroA-like domain). These proteins have been shown to function in the ABC transport of ferric siderophores and metal ions such as Mn2+, Fe3+, Cu2+ and/or Zn2+. Their ligand binding site is formed in the interface between...; Region: TroA-like; cl00262 441771000926 intersubunit interface [polypeptide binding]; other site 441771000927 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550 441771000928 ABC-ATPase subunit interface; other site 441771000929 dimer interface [polypeptide binding]; other site 441771000930 putative PBP binding regions; other site 441771000931 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550 441771000932 ABC-ATPase subunit interface; other site 441771000933 dimer interface [polypeptide binding]; other site 441771000934 putative PBP binding regions; other site 441771000935 ABC-type cobalamin/Fe3+-siderophores transport systems, ATPase components [Inorganic ion transport and metabolism / Coenzyme metabolism]; Region: FepC; COG1120 441771000936 ATP-binding component of iron-siderophores, vitamin B12 and hemin transporters and related proteins; Region: ABC_Iron-Siderophores_B12_Hemin; cd03214 441771000937 Walker A/P-loop; other site 441771000938 ATP binding site [chemical binding]; other site 441771000939 Q-loop/lid; other site 441771000940 ABC transporter signature motif; other site 441771000941 Walker B; other site 441771000942 D-loop; other site 441771000943 H-loop/switch region; other site 441771000944 ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132 441771000945 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 441771000946 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 441771000947 Walker A/P-loop; other site 441771000948 ATP binding site [chemical binding]; other site 441771000949 Q-loop/lid; other site 441771000950 ABC transporter signature motif; other site 441771000951 Walker B; other site 441771000952 D-loop; other site 441771000953 H-loop/switch region; other site 441771000954 Iron dependent repressor, N-terminal DNA binding domain; Region: Fe_dep_repress; pfam01325 441771000955 Helix-turn-helix diphteria tox regulatory element; Region: HTH_DTXR; smart00529 441771000956 Iron dependent repressor, metal binding and dimerization domain; Region: Fe_dep_repr_C; pfam02742 441771000957 Sulfate transporter family; Region: Sulfate_transp; cl19250 441771000958 xanthine permease; Region: pbuX; TIGR03173 441771000959 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 441771000960 active site 441771000961 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 441771000962 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 441771000963 active site 441771000964 phosphorylation site [posttranslational modification] 441771000965 intermolecular recognition site; other site 441771000966 dimerization interface [polypeptide binding]; other site 441771000967 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 441771000968 DNA binding site [nucleotide binding] 441771000969 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 441771000970 His Kinase A (phospho-acceptor) domain; Region: HisKA; pfam00512 441771000971 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 441771000972 ATP binding site [chemical binding]; other site 441771000973 Mg2+ binding site [ion binding]; other site 441771000974 G-X-G motif; other site 441771000975 undecaprenyl pyrophosphate phosphatase; Reviewed; Region: PRK00281 441771000976 ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136 441771000977 ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255 441771000978 Walker A/P-loop; other site 441771000979 ATP binding site [chemical binding]; other site 441771000980 Q-loop/lid; other site 441771000981 ABC transporter signature motif; other site 441771000982 Walker B; other site 441771000983 D-loop; other site 441771000984 H-loop/switch region; other site 441771000985 ABC-type antimicrobial peptide transport system, permease component [Defense mechanisms]; Region: SalY; COG0577 441771000986 FtsX-like permease family; Region: FtsX; pfam02687 441771000987 LrgA family; Region: LrgA; pfam03788 441771000988 LrgB-like family; Region: LrgB; pfam04172 441771000989 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 441771000990 Radical SAM superfamily; Region: Radical_SAM; pfam04055 441771000991 FeS/SAM binding site; other site 441771000992 hypothetical protein; Provisional; Region: PRK13663 441771000993 Accessory gene regulator B; Region: AgrB; pfam04647 441771000994 cyclic lactone autoinducer peptide; Region: quorum_AgrD; TIGR04223 441771000995 Domain of unknown function (DUF4118); Region: DUF4118; pfam13493 441771000996 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 441771000997 metal binding site [ion binding]; metal-binding site 441771000998 active site 441771000999 I-site; other site 441771001000 c-di-GMP phosphodiesterase class II (HD-GYP domain) [Signal transduction mechanisms]; Region: COG2206 441771001001 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 441771001002 Zn2+ binding site [ion binding]; other site 441771001003 Mg2+ binding site [ion binding]; other site 441771001004 Acetyltransferase (GNAT) domain; Region: Acetyltransf_3; pfam13302 441771001005 Acetyltransferase (GNAT) family; Region: Acetyltransf_1; pfam00583 441771001006 Domain of unknown function (DUF4118); Region: DUF4118; pfam13493 441771001007 PAS domain S-box; Region: sensory_box; TIGR00229 441771001008 PAS domain; Region: PAS; smart00091 441771001009 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 441771001010 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 441771001011 dimer interface [polypeptide binding]; other site 441771001012 phosphorylation site [posttranslational modification] 441771001013 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 441771001014 ATP binding site [chemical binding]; other site 441771001015 Mg2+ binding site [ion binding]; other site 441771001016 G-X-G motif; other site 441771001017 Accessory gene regulator B; Region: AgrB; pfam04647 441771001018 cyclic lactone autoinducer peptide; Region: quorum_AgrD; TIGR04223 441771001019 Membrane-associating domain; Region: MARVEL; pfam01284 441771001020 Domain of unknown function (DUF4118); Region: DUF4118; pfam13493 441771001021 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: VicK; COG5002 441771001022 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 441771001023 dimer interface [polypeptide binding]; other site 441771001024 phosphorylation site [posttranslational modification] 441771001025 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 441771001026 ATP binding site [chemical binding]; other site 441771001027 Mg2+ binding site [ion binding]; other site 441771001028 G-X-G motif; other site 441771001029 tRNA 2-thiocytidine biosynthesis protein TtcA; Provisional; Region: PRK10696 441771001030 This is a subfamily of Adenine nucleotide alpha hydrolases superfamily.Adeninosine nucleotide alpha hydrolases superfamily includes N type ATP PPases and ATP sulphurylases. It forms a apha/beta/apha fold which binds to Adenosine group. This subfamily; Region: Alpha_ANH_like_II; cd01993 441771001031 Ligand Binding Site [chemical binding]; other site 441771001032 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 441771001033 DNA-binding transcriptional repressor PuuR; Provisional; Region: PRK09943 441771001034 non-specific DNA binding site [nucleotide binding]; other site 441771001035 salt bridge; other site 441771001036 sequence-specific DNA binding site [nucleotide binding]; other site 441771001037 Cupin domain; Region: Cupin_2; pfam07883 441771001038 putative glutamate/gamma-aminobutyrate antiporter; Region: put_Glu_GABA_T; TIGR03813 441771001039 Transmembrane amino acid transporter protein; Region: Aa_trans; cl17468 441771001040 Xaa-Pro aminopeptidase [Amino acid transport and metabolism]; Region: PepP; COG0006 441771001041 Creatinase/Prolidase N-terminal domain; Region: Creatinase_N; pfam01321 441771001042 Similar to Prolidase and Aminopeptidase P. The members of this subfamily presumably catalyse hydrolysis of Xaa-Pro dipeptides and/or release of any N-terminal amino acid, including proline, that is linked with proline; Region: APP-like; cd01092 441771001043 active site 441771001044 bifunctional acetaldehyde-CoA/alcohol dehydrogenase; Provisional; Region: PRK13805 441771001045 Coenzyme A acylating aldehyde dehydrogenase (ACDH), ALDH family 20-like; Region: ALDH_F20_ACDH; cd07122 441771001046 putative catalytic cysteine [active] 441771001047 C-terminal alcohol dehydrogenase domain of the acetaldehyde dehydrogenase-alcohol dehydrogenase bifunctional two-domain protein (AAD); Region: AAD_C; cd08178 441771001048 putative active site [active] 441771001049 metal binding site [ion binding]; metal-binding site 441771001050 Uncharacterized protein conserved in bacteria (DUF2325); Region: DUF2325; cl01811 441771001051 Protein of unknown function (DUF3793); Region: DUF3793; pfam12672 441771001052 Protein of unknown function (DUF3189); Region: DUF3189; pfam11385 441771001053 Membrane-associated phospholipid phosphatase [Lipid metabolism]; Region: PgpB; COG0671 441771001054 PAP2_like proteins, a super-family of histidine phosphatases and vanadium haloperoxidases, includes type 2 phosphatidic acid phosphatase or lipid phosphate phosphatase (LPP), Glucose-6-phosphatase, Phosphatidylglycerophosphatase B and bacterial acid...; Region: PAP2_like; cl00474 441771001055 active site 441771001056 Predicted xylanase/chitin deacetylase [Carbohydrate transport and metabolism]; Region: CDA1; COG0726 441771001057 Catalytic NodB homology domain of Streptococcus mutans polysaccharide deacetylase PgdA, Bacillus subtilis YheN, and similar proteins; Region: CE4_SmPgdA_like; cd10944 441771001058 NodB motif; other site 441771001059 active site 441771001060 catalytic site [active] 441771001061 Zn binding site [ion binding]; other site 441771001062 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 441771001063 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 441771001064 active site 441771001065 phosphorylation site [posttranslational modification] 441771001066 intermolecular recognition site; other site 441771001067 dimerization interface [polypeptide binding]; other site 441771001068 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 441771001069 DNA binding site [nucleotide binding] 441771001070 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 441771001071 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 441771001072 dimerization interface [polypeptide binding]; other site 441771001073 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 441771001074 dimer interface [polypeptide binding]; other site 441771001075 phosphorylation site [posttranslational modification] 441771001076 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 441771001077 ATP binding site [chemical binding]; other site 441771001078 Mg2+ binding site [ion binding]; other site 441771001079 G-X-G motif; other site 441771001080 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 441771001081 S-adenosylmethionine binding site [chemical binding]; other site 441771001082 Putative rRNA methylase; Region: rRNA_methylase; pfam06962 441771001083 Uncharacterized conserved protein [Function unknown]; Region: COG0398 441771001084 CHASE4 domain; Region: CHASE4; pfam05228 441771001085 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 441771001086 dimerization interface [polypeptide binding]; other site 441771001087 PAS domain; Region: PAS_9; pfam13426 441771001088 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 441771001089 metal binding site [ion binding]; metal-binding site 441771001090 active site 441771001091 I-site; other site 441771001092 EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2). The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948 441771001093 Putative amidase domain; Region: Amidase_6; pfam12671 441771001094 Na+-driven multidrug efflux pump [Defense mechanisms]; Region: NorM; COG0534 441771001095 Subfamily of the multidrug and toxic compound extrusion (MATE)-like proteins similar to Thermotoga marina NorM; Region: MATE_NorM_like; cd13137 441771001096 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cl17215 441771001097 NhaP-type Na+/H+ and K+/H+ antiporters [Inorganic ion transport and metabolism]; Region: NhaP; COG0025 441771001098 Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl18945 441771001099 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 441771001100 catalytic residue [active] 441771001101 Predicted membrane protein [Function unknown]; Region: COG2855 441771001102 PAP2_like proteins, a super-family of histidine phosphatases and vanadium haloperoxidases, includes type 2 phosphatidic acid phosphatase or lipid phosphate phosphatase (LPP), Glucose-6-phosphatase, Phosphatidylglycerophosphatase B and bacterial acid...; Region: PAP2_like; cl00474 441771001103 active site 441771001104 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 441771001105 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 441771001106 active site 441771001107 phosphorylation site [posttranslational modification] 441771001108 intermolecular recognition site; other site 441771001109 dimerization interface [polypeptide binding]; other site 441771001110 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 441771001111 DNA binding site [nucleotide binding] 441771001112 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 441771001113 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 441771001114 dimerization interface [polypeptide binding]; other site 441771001115 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 441771001116 dimer interface [polypeptide binding]; other site 441771001117 phosphorylation site [posttranslational modification] 441771001118 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 441771001119 ATP binding site [chemical binding]; other site 441771001120 Mg2+ binding site [ion binding]; other site 441771001121 G-X-G motif; other site 441771001122 Solute carrier 5 family, sodium/glucose transporters and related proteins; solute-binding domain; Region: SLC5sbd; cd10322 441771001123 Na binding site [ion binding]; other site 441771001124 electron transport complex, RnfABCDGE type, C subunit; Region: rnfC; TIGR01945 441771001125 RnfC Barrel sandwich hybrid domain; Region: RnfC_N; pfam13375 441771001126 Respiratory-chain NADH dehydrogenase 51 Kd subunit; Region: Complex1_51K; pfam01512 441771001127 SLBB domain; Region: SLBB; pfam10531 441771001128 4Fe-4S dicluster domain; Region: Fer4_17; pfam13534 441771001129 NQR2, RnfD, RnfE family; Region: NQR2_RnfD_RnfE; pfam03116 441771001130 FMN-binding domain; Region: FMN_bind; cl01081 441771001131 electron transport complex RsxE subunit; Provisional; Region: PRK12405 441771001132 electron transport complex, RnfABCDGE type, A subunit; Region: rnfA; TIGR01943 441771001133 ferredoxin; Validated; Region: PRK07118 441771001134 Putative Fe-S cluster; Region: FeS; cl17515 441771001135 CheD chemotactic sensory transduction; Region: CheD; cl00810 441771001136 The HCP family of iron-sulfur proteins includes hybrid cluster protein (HCP), acetyl-CoA synthase (ACS), and carbon monoxide dehydrogenase (CODH), all of which contain [Fe4-S4] metal clusters at their active sites. These proteins have a conserved...; Region: HCP_like; cl19102 441771001137 The HCP family of iron-sulfur proteins includes hybrid cluster protein (HCP), acetyl-CoA synthase (ACS), and carbon monoxide dehydrogenase (CODH), all of which contain [Fe4-S4] metal clusters at their active sites. These proteins have a conserved...; Region: HCP_like; cl19102 441771001138 4Fe-4S binding domain; Region: Fer4; pfam00037 441771001139 Putative cell wall binding repeat 2; Region: CW_binding_2; pfam04122 441771001140 Putative cell wall binding repeat 2; Region: CW_binding_2; pfam04122 441771001141 Putative cell wall binding repeat 2; Region: CW_binding_2; pfam04122 441771001142 Heptaprenyl diphosphate synthase component I; Region: Hpre_diP_synt_I; pfam07456 441771001143 Listerrria innocua Lin0431 is similar to the N-Utilization Substance G (NusG) N terminal (NGN) insert (DII); Region: Lin0431_like; cd09911 441771001144 trimer interface [polypeptide binding]; other site 441771001145 Membrane-associated lipoprotein involved in thiamine biosynthesis [Coenzyme metabolism]; Region: ApbE; COG1477 441771001146 Cache domain; Region: Cache_1; pfam02743 441771001147 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 441771001148 dimerization interface [polypeptide binding]; other site 441771001149 Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer); Region: MA; smart00283 441771001150 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 441771001151 dimer interface [polypeptide binding]; other site 441771001152 putative CheW interface [polypeptide binding]; other site 441771001153 FtsH Extracellular; Region: FtsH_ext; pfam06480 441771001154 ATP-dependent Zn proteases [Posttranslational modification, protein turnover, chaperones]; Region: HflB; COG0465 441771001155 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 441771001156 Walker A motif; other site 441771001157 ATP binding site [chemical binding]; other site 441771001158 Walker B motif; other site 441771001159 arginine finger; other site 441771001160 Peptidase family M41; Region: Peptidase_M41; pfam01434 441771001161 Protein of unknown function (DUF1232); Region: DUF1232; pfam06803 441771001162 RNase HI family found mainly in prokaryotes; Region: RNase_HI_prokaryote_like; cd09278 441771001163 RNA/DNA hybrid binding site [nucleotide binding]; other site 441771001164 active site 441771001165 YtxH-like protein; Region: YtxH; pfam12732 441771001166 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 441771001167 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 441771001168 non-specific DNA binding site [nucleotide binding]; other site 441771001169 salt bridge; other site 441771001170 sequence-specific DNA binding site [nucleotide binding]; other site 441771001171 Tetratricopeptide repeat; Region: TPR_12; pfam13424 441771001172 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 441771001173 binding surface 441771001174 TPR motif; other site 441771001175 Tetratricopeptide repeat; Region: TPR_12; pfam13424 441771001176 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 441771001177 non-specific DNA binding site [nucleotide binding]; other site 441771001178 salt bridge; other site 441771001179 sequence-specific DNA binding site [nucleotide binding]; other site 441771001180 Tetratricopeptide repeat; Region: TPR_12; pfam13424 441771001181 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 441771001182 Putative lysophospholipase; Region: Hydrolase_4; cl19140 441771001183 DJ-1 family protein; Region: not_thiJ; TIGR01383 441771001184 Type 1 glutamine amidotransferase (GATase1)-like domain found in a subgroup of proteins similar to PfpI from Pyrococcus furiosus; Region: GATase1_PfpI_2; cd03139 441771001185 conserved cys residue [active] 441771001186 Domain of unknown function (DUF2935); Region: DUF2935; pfam11155 441771001187 Domain of unknown function (DUF2935); Region: DUF2935; pfam11155 441771001188 ATP-dependent chaperone ClpB; Region: chaperone_ClpB; TIGR03346 441771001189 Clp amino terminal domain; Region: Clp_N; pfam02861 441771001190 Clp amino terminal domain; Region: Clp_N; pfam02861 441771001191 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 441771001192 Walker A motif; other site 441771001193 ATP binding site [chemical binding]; other site 441771001194 Walker B motif; other site 441771001195 arginine finger; other site 441771001196 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 441771001197 Walker A motif; other site 441771001198 ATP binding site [chemical binding]; other site 441771001199 Walker B motif; other site 441771001200 arginine finger; other site 441771001201 C-terminal, D2-small domain, of ClpB protein; Region: ClpB_D2-small; pfam10431 441771001202 DNA-binding transcriptional regulator AsnC; Provisional; Region: PRK11179 441771001203 helix_turn_helix ASNC type; Region: HTH_ASNC; smart00344 441771001204 putative DNA binding site [nucleotide binding]; other site 441771001205 putative Zn2+ binding site [ion binding]; other site 441771001206 transporter, basic amino acid/polyamine antiporter (APA) family; Region: 2A0302; TIGR00905 441771001207 Spore germination protein; Region: Spore_permease; cl17796 441771001208 Transmembrane amino acid transporter protein; Region: Aa_trans; cl17468 441771001209 Transmembrane amino acid transporter protein; Region: Aa_trans; cl17468 441771001210 transporter, basic amino acid/polyamine antiporter (APA) family; Region: 2A0302; TIGR00905 441771001211 Carbonic anhydrases/acetyltransferases, isoleucine patch superfamily [General function prediction only]; Region: PaaY; COG0663 441771001212 Gamma carbonic anhydrase-like: This family is composed of gamma carbonic anhydrase (CA), Ferripyochelin Binding Protein (FBP), E. coli paaY protein, and similar proteins. CAs are zinc-containing enzymes that catalyze the reversible hydration of carbon...; Region: LbH_gamma_CA_like; cd04645 441771001213 trimer interface [polypeptide binding]; other site 441771001214 putative metal binding site [ion binding]; other site 441771001215 Metallo-beta-lactamase superfamily; Region: Lactamase_B; pfam00753 441771001216 Cation transporter/ATPase, N-terminus; Region: Cation_ATPase_N; pfam00690 441771001217 Cation transport ATPase [Inorganic ion transport and metabolism]; Region: MgtA; COG0474 441771001218 E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122 441771001219 Putative hydrolase of sodium-potassium ATPase alpha subunit; Region: Hydrolase_like2; pfam13246 441771001220 haloacid dehalogenase-like hydrolase; Region: HAD; pfam12710 441771001221 Cation transporting ATPase, C-terminus; Region: Cation_ATPase_C; pfam00689 441771001222 Chromate transporter; Region: Chromate_transp; pfam02417 441771001223 Chromate transporter; Region: Chromate_transp; pfam02417 441771001224 PemK-like protein; Region: PemK; pfam02452 441771001225 Protein of unknown function (DUF327); Region: DUF327; pfam03885 441771001226 NAD synthetase; Reviewed; Region: nadE; PRK02628 441771001227 Glutamine aminotransferase (GAT, glutaminase) domain of glutamine-dependent NAD synthetases (class 7 and 8 nitrilases); Region: GAT_Gln-NAD-synth; cd07570 441771001228 multimer interface [polypeptide binding]; other site 441771001229 active site 441771001230 catalytic triad [active] 441771001231 protein interface 1 [polypeptide binding]; other site 441771001232 NAD+ synthase is a homodimer, which catalyzes the final step in de novo nicotinamide adenine dinucleotide (NAD+) biosynthesis, an amide transfer from either ammonia or glutamine to nicotinic acid adenine dinucleotide (NaAD). The conversion of NaAD to NAD...; Region: NAD_synthase; cd00553 441771001233 homodimer interface [polypeptide binding]; other site 441771001234 NAD binding pocket [chemical binding]; other site 441771001235 ATP binding pocket [chemical binding]; other site 441771001236 Mg binding site [ion binding]; other site 441771001237 active-site loop [active] 441771001238 Membrane protein implicated in regulation of membrane protease activity [Posttranslational modification, protein turnover, chaperones / Intracellular trafficking and secretion]; Region: COG1585 441771001239 Membrane protease subunits, stomatin/prohibitin homologs [Posttranslational modification, protein turnover, chaperones]; Region: HflC; COG0330 441771001240 Paraslipin or slipin-2 (SLP-2, a subgroup of the stomatin-like proteins (slipins) family; belonging to the SPFH (stomatin, prohibitin, flotillin, and HflK/C) superfamily; Region: SPFH_paraslipin; cd08829 441771001241 SigmaW regulon antibacterial; Region: YdfA_immunity; cl12057 441771001242 CAAX protease self-immunity; Region: Abi; pfam02517 441771001243 proline aminopeptidase P II; Provisional; Region: PRK10879 441771001244 Aminopeptidase P, N-terminal domain; Region: AMP_N; smart01011 441771001245 Prolidase. E.C. 3.4.13.9. Also known as Xaa-Pro dipeptidase, X-Pro dipeptidase, proline dipeptidase., imidodipeptidase, peptidase D, gamma-peptidase. Catalyses hydrolysis of Xaa-Pro dipeptides; also acts on aminoacyl-hydroxyproline analogs. No action on...; Region: Prolidase; cd01087 441771001246 active site 441771001247 Type 1 glutamine amidotransferase (GATase1) domain found in Cobyric Acid Synthase (CobQ); Region: GATase1_CobQ; cd01750 441771001248 catalytic triad [active] 441771001249 UDP-N-acetylmuramyl tripeptide synthase [Cell envelope biogenesis, outer membrane]; Region: MurE; COG0769 441771001250 Mur ligase middle domain; Region: Mur_ligase_M; pfam08245 441771001251 Domain of unknown function (DUF1727); Region: DUF1727; pfam08353 441771001252 Phosphomannose isomerase [Carbohydrate transport and metabolism]; Region: ManA; COG1482 441771001253 Alpha-Mannosidase Binding Domain of Atg19/34; Region: ABD; cl19057 441771001254 undecaprenyl pyrophosphate phosphatase; Reviewed; Region: PRK12554 441771001255 Predicted hydrolase (metallo-beta-lactamase superfamily) [General function prediction only]; Region: ComEC; COG2333 441771001256 Metallo-beta-lactamase superfamily; Region: Lactamase_B; pfam00753 441771001257 Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: AGPAT-like; Region: LPLAT_AGPAT-like; cd07989 441771001258 putative acyl-acceptor binding pocket; other site 441771001259 isopropylmalate/citramalate/homocitrate synthases; Region: LEU1_arch; TIGR02090 441771001260 Clostridium kluyveri Re-citrate synthase and related proteins, catalytic TIM barrel domain; Region: DRE_TIM_Re_CS; cd07947 441771001261 active site 441771001262 catalytic residues [active] 441771001263 metal binding site [ion binding]; metal-binding site 441771001264 aconitate hydratase; Validated; Region: PRK07229 441771001265 Aconitase catalyzes the reversible isomerization of citrate and isocitrate as part of the TCA cycle; Region: AcnA_Bact; cd01585 441771001266 substrate binding site [chemical binding]; other site 441771001267 ligand binding site [chemical binding]; other site 441771001268 Aconitase swivel domain. Aconitase (aconitate hydratase) catalyzes the reversible isomerization of citrate and isocitrate as part of the TCA cycle. This is the aconitase swivel domain, which undergoes swivelling conformational change in the enzyme...; Region: Aconitase_swivel; cl00215 441771001269 substrate binding site [chemical binding]; other site 441771001270 Isocitrate/isopropylmalate dehydrogenase [Amino acid transport and metabolism]; Region: LeuB; COG0473 441771001271 ABC-type polar amino acid transport system, ATPase component [Amino acid transport and metabolism]; Region: GlnQ; COG1126 441771001272 ATP-binding cassette domain of the histidine and glutamine transporters; Region: ABC_HisP_GlnQ; cd03262 441771001273 Walker A/P-loop; other site 441771001274 ATP binding site [chemical binding]; other site 441771001275 Q-loop/lid; other site 441771001276 ABC transporter signature motif; other site 441771001277 Walker B; other site 441771001278 D-loop; other site 441771001279 H-loop/switch region; other site 441771001280 Na+/H+ antiporter [Energy production and conversion]; Region: NhaC; COG1757 441771001281 Anion permease ArsB/NhaD. These permeases have been shown to translocate sodium, arsenate, antimonite, sulfate and organic anions across biological membranes in all three kingdoms of life. A typical anion permease contains 8-13 transmembrane helices...; Region: ArsB_NhaD_permease; cl17221 441771001282 Na+/H+ antiporter family; Region: Na_H_antiporter; pfam03553 441771001283 Uncharacterized conserved protein [Function unknown]; Region: COG2155 441771001284 Aspartate alpha-decarboxylase or L-aspartate 1-decarboxylase, a pyruvoyl group-dependent decarboxylase in beta-alanine production; Region: Asp_decarbox; cd06919 441771001285 tetramerization interface [polypeptide binding]; other site 441771001286 active site 441771001287 Pantoate-beta-alanine ligase; Region: PanC; cd00560 441771001288 active site 441771001289 ATP-binding site [chemical binding]; other site 441771001290 pantoate-binding site; other site 441771001291 HXXH motif; other site 441771001292 Ketopantoate hydroxymethyltransferase (KPHMT) is the first enzyme in the pantothenate biosynthesis pathway. Ketopantoate hydroxymethyltransferase (KPHMT) catalyzes the first committed step in the biosynthesis of pantothenate (vitamin B5), which is a...; Region: KPHMT-like; cd06557 441771001293 oligomerization interface [polypeptide binding]; other site 441771001294 active site 441771001295 metal binding site [ion binding]; metal-binding site 441771001296 helicase-exonuclease AddAB, AddB subunit; Region: addB_Gpos; TIGR02773 441771001297 Exodeoxyribonuclease V, gamma subunit; Region: Exonuc_V_gamma; cl19914 441771001298 PD-(D/E)XK nuclease superfamily; Region: PDDEXK_1; pfam12705 441771001299 Apolipophorin-III and similar insect proteins; Region: ApoLp-III_like; cl19113 441771001300 ABC-2 family transporter protein; Region: ABC2_membrane_3; pfam12698 441771001301 ABC-2 family transporter protein; Region: ABC2_membrane_2; pfam12679 441771001302 gallidermin-class lantibiotic protection ABC transporter, ATP-binding subunit; Region: galliderm_ABC; TIGR03740 441771001303 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 441771001304 Walker A/P-loop; other site 441771001305 ATP binding site [chemical binding]; other site 441771001306 Q-loop/lid; other site 441771001307 ABC transporter signature motif; other site 441771001308 Walker B; other site 441771001309 D-loop; other site 441771001310 H-loop/switch region; other site 441771001311 Predicted transcriptional regulators [Transcription]; Region: COG1695 441771001312 radical SAM peptide maturase, CXXX-repeat target family; Region: rSAM_Cxxx_rpt; TIGR04115 441771001313 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 441771001314 FeS/SAM binding site; other site 441771001315 radical SAM additional 4Fe4S-binding SPASM domain; Region: rSAM_more_4Fe4S; TIGR04085 441771001316 CXXX repeat peptide maturase; Region: CXXX_matur; TIGR04119 441771001317 CXXX repeat peptide modification system protein; Region: CXXX_rpt_assoc; TIGR04116 441771001318 ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132 441771001319 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 441771001320 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 441771001321 Walker A/P-loop; other site 441771001322 ATP binding site [chemical binding]; other site 441771001323 Q-loop/lid; other site 441771001324 ABC transporter signature motif; other site 441771001325 Walker B; other site 441771001326 D-loop; other site 441771001327 H-loop/switch region; other site 441771001328 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 441771001329 TPR motif; other site 441771001330 Tetratricopeptide repeat; Region: TPR_12; pfam13424 441771001331 binding surface 441771001332 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 441771001333 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 441771001334 The Fer4_NifH superfamily contains a variety of proteins which share a common ATP-binding domain. Functionally, proteins in this superfamily use the energy from hydrolysis of NTP to transfer electron or ion; Region: Fer4_NifH; cl17203 441771001335 Ferredoxin [Energy production and conversion]; Region: NapF; COG1145 441771001336 4Fe-4S binding domain; Region: Fer4; pfam00037 441771001337 Dihydroprymidine dehydrogenase domain II, 4Fe-4S cluster; Region: Fer4_20; pfam14691 441771001338 NADPH-dependent glutamate synthase beta chain and related oxidoreductases [Amino acid transport and metabolism / General function prediction only]; Region: GltD; COG0493 441771001339 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl19134 441771001340 Hydrogenase expression/synthesis hypA family; Region: HypA; pfam01155 441771001341 helicase-exonuclease AddAB, AddA subunit, Firmicutes type; Region: addA_Gpos; TIGR02785 441771001342 Part of AAA domain; Region: AAA_19; pfam13245 441771001343 UvrD-like helicase C-terminal domain; Region: UvrD_C_2; pfam13538 441771001344 Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer); Region: MA; smart00283 441771001345 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 441771001346 dimer interface [polypeptide binding]; other site 441771001347 putative CheW interface [polypeptide binding]; other site 441771001348 M20 Peptidase T specifically cleaves tripeptides; Region: M20_peptT; cd03892 441771001349 peptidase T-like protein; Region: PepT-like; TIGR01883 441771001350 metal binding site [ion binding]; metal-binding site 441771001351 dimer interface [polypeptide binding]; other site 441771001352 ExoU and VipD-like proteins; homologus to patatin, cPLA2, and iPLA2; Region: Pat_ExoU_VipD_like; cd07207 441771001353 nucleophile elbow; other site 441771001354 Metallo-beta-lactamase superfamily; Region: Lactamase_B; smart00849 441771001355 This domain superfamily is found in a variety of structurally related metalloproteins, including the type I extradiol dioxygenases, glyoxalase I and a group of antibiotic resistance proteins; Region: Glo_EDI_BRP_like; cl14632 441771001356 active site 441771001357 metal binding site [ion binding]; metal-binding site 441771001358 Putative cell wall binding repeat 2; Region: CW_binding_2; pfam04122 441771001359 Putative cell wall binding repeat 2; Region: CW_binding_2; pfam04122 441771001360 Putative cell wall binding repeat 2; Region: CW_binding_2; pfam04122 441771001361 ABC-type amino acid transport system, permease component [Amino acid transport and metabolism]; Region: HisM; COG0765 441771001362 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 441771001363 dimer interface [polypeptide binding]; other site 441771001364 conserved gate region; other site 441771001365 putative PBP binding loops; other site 441771001366 ABC-ATPase subunit interface; other site 441771001367 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 441771001368 Bacterial extracellular solute-binding proteins, family 3; Region: SBP_bac_3; pfam00497 441771001369 substrate binding pocket [chemical binding]; other site 441771001370 membrane-bound complex binding site; other site 441771001371 hinge residues; other site 441771001372 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 441771001373 S-adenosylmethionine binding site [chemical binding]; other site 441771001374 Predicted signal transduction protein containing EAL and modified HD-GYP domains [Signal transduction mechanisms]; Region: COG3434 441771001375 EAL domain; Region: EAL; pfam00563 441771001376 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cl17215 441771001377 Thiamine monophosphate synthase (TMP synthase)/TenI. TMP synthase catalyzes an important step in the thiamine biosynthesis pathway, the substitution of the pyrophosphate of 2-methyl-4-amino-5- hydroxymethylpyrimidine pyrophosphate by 4-methyl-5-; Region: TMP_TenI; cd00564 441771001378 thiamine phosphate binding site [chemical binding]; other site 441771001379 active site 441771001380 pyrophosphate binding site [ion binding]; other site 441771001381 4-methyl-5-beta-hydroxyethylthiazole (Thz) kinase catalyzes the phosphorylation of the hydroxylgroup of Thz. A reaction that allows cells to recycle Thz into the thiamine biosynthesis pathway, as an alternative to its synthesis from cysteine, tyrosine...; Region: THZ_kinase; cd01170 441771001382 substrate binding site [chemical binding]; other site 441771001383 multimerization interface [polypeptide binding]; other site 441771001384 ATP binding site [chemical binding]; other site 441771001385 4-amino-5-hydroxymethyl-2-methyl-pyrimidine phosphate kinase (HMPP-kinase) catalyzes two consecutive phosphorylation steps in the thiamine phosphate biosynthesis pathway, leading to the synthesis of vitamin B1. The first step is the phosphorylation of...; Region: HMPP_kinase; cd01169 441771001386 dimer interface [polypeptide binding]; other site 441771001387 substrate binding site [chemical binding]; other site 441771001388 ATP binding site [chemical binding]; other site 441771001389 D-alanine--D-alanine ligase; Reviewed; Region: ddl; PRK01372 441771001390 D-ala D-ala ligase N-terminus; Region: Dala_Dala_lig_N; pfam01820 441771001391 ATP-grasp domain; Region: ATP-grasp_4; cl17255 441771001392 Type I periplasmic ligand-binding domain of ABC (Atpase Binding Cassette)-type active transport systems that are involved in the transport of all three branched chain aliphatic amino acids (leucine, isoleucine and valine); Region: PBP1_ABC_LIVBP_like; cd06342 441771001393 dimerization interface [polypeptide binding]; other site 441771001394 Receptor family ligand binding region; Region: ANF_receptor; pfam01094 441771001395 ligand binding site [chemical binding]; other site 441771001396 Transmembrane subunit (TM) of Escherichia coli LivH and related proteins. LivH is one of two TMs of the E. coli LIV-1/LS transporter, a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of...; Region: TM_PBP1_LivH_like; cd06582 441771001397 TM-ABC transporter signature motif; other site 441771001398 Transmembrane subunit (TM) of Escherichia coli LivM and related proteins. LivM is one of two TMs of the E. coli LIV-1/LS transporter, a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of...; Region: TM_PBP1_LivM_like; cd06581 441771001399 TM-ABC transporter signature motif; other site 441771001400 ABC-type branched-chain amino acid transport systems, ATPase component [Amino acid transport and metabolism]; Region: LivG; COG0411 441771001401 ATP-binding cassette component of branched chain amino acids transport system; Region: ABC_Mj1267_LivG_branched; cd03219 441771001402 Walker A/P-loop; other site 441771001403 ATP binding site [chemical binding]; other site 441771001404 Q-loop/lid; other site 441771001405 ABC transporter signature motif; other site 441771001406 Walker B; other site 441771001407 D-loop; other site 441771001408 H-loop/switch region; other site 441771001409 ABC-type branched-chain amino acid transport systems, ATPase component [Amino acid transport and metabolism]; Region: LivF; COG0410 441771001410 ATP-binding cassette domain of branched-chain amino acid transporter; Region: ABC_TM1139_LivF_branched; cd03224 441771001411 Walker A/P-loop; other site 441771001412 ATP binding site [chemical binding]; other site 441771001413 Q-loop/lid; other site 441771001414 ABC transporter signature motif; other site 441771001415 Walker B; other site 441771001416 D-loop; other site 441771001417 H-loop/switch region; other site 441771001418 Uncharacterized ArCR, COG2043; Region: DUF169; pfam02596 441771001419 Protein of unknown function (DUF3815); Region: DUF3815; pfam12821 441771001420 Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain (MocR family) and their eukaryotic orthologs [Transcription / Amino acid transport and metabolism]; Region: ARO8; COG1167 441771001421 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 441771001422 DNA-binding site [nucleotide binding]; DNA binding site 441771001423 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 441771001424 pyridoxal 5'-phosphate binding site [chemical binding]; other site 441771001425 homodimer interface [polypeptide binding]; other site 441771001426 catalytic residue [active] 441771001427 LemA family; Region: LemA; cl00742 441771001428 TLP18.3, Psb32 and MOLO-1 founding proteins of phosphatase; Region: TPM; cl01535 441771001429 TLP18.3, Psb32 and MOLO-1 founding proteins of phosphatase; Region: TPM; cl01535 441771001430 Nudix hydrolase is a superfamily of enzymes found in all three kingdoms of life, and it catalyzes the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+...; Region: Nudix_Hydrolase; cd02883 441771001431 nudix motif; other site 441771001432 Protein of unknown function (DUF3816); Region: DUF3816; pfam12822 441771001433 Methyltransferase domain; Region: Methyltransf_31; pfam13847 441771001434 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 441771001435 S-adenosylmethionine binding site [chemical binding]; other site 441771001436 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 441771001437 salt bridge; other site 441771001438 non-specific DNA binding site [nucleotide binding]; other site 441771001439 sequence-specific DNA binding site [nucleotide binding]; other site 441771001440 Protein of unknown function (DUF2975); Region: DUF2975; pfam11188 441771001441 DNA repair exonuclease [DNA replication, recombination, and repair]; Region: SbcD; COG0420 441771001442 Mre11 nuclease, N-terminal metallophosphatase domain; Region: MPP_Mre11_N; cd00840 441771001443 active site 441771001444 metal binding site [ion binding]; metal-binding site 441771001445 DNA binding site [nucleotide binding] 441771001446 Type 5 capsule protein repressor C-terminal domain; Region: SbcD_C; pfam12320 441771001447 exonuclease SbcC; Region: sbcc; TIGR00618 441771001448 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 441771001449 Walker A/P-loop; other site 441771001450 ATP binding site [chemical binding]; other site 441771001451 Q-loop/lid; other site 441771001452 Rat sarcoma (Ras)-like superfamily of small guanosine triphosphatases (GTPases); Region: Ras_like_GTPase; cl17170 441771001453 G4 box; other site 441771001454 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 441771001455 ABC transporter signature motif; other site 441771001456 Walker B; other site 441771001457 D-loop; other site 441771001458 H-loop/switch region; other site 441771001459 ADP-ribose pyrophosphatase (ADPRase) catalyzes the hydrolysis of ADP-ribose and a variety of additional ADP-sugar conjugates to AMP and ribose-5-phosphate. Like other members of the Nudix hydrolase superfamily, it requires a divalent cation, such as Mg2+; Region: ADPRase_NUDT5; cd03424 441771001460 ADP-ribose binding site [chemical binding]; other site 441771001461 dimer interface [polypeptide binding]; other site 441771001462 active site 441771001463 nudix motif; other site 441771001464 metal binding site [ion binding]; metal-binding site 441771001465 Uncharacterized conserved protein [Function unknown]; Region: COG1284 441771001466 Uncharacterized BCR, YitT family COG1284; Region: DUF161; pfam02588 441771001467 Uncharacterized BCR, YitT family COG1284; Region: DUF161; pfam02588 441771001468 Uncharacterized protein conserved in bacteria (DUF2179); Region: DUF2179; pfam10035 441771001469 Cation transport ATPase [Inorganic ion transport and metabolism]; Region: ZntA; COG2217 441771001470 Heavy-metal-associated domain (HMA) is a conserved domain of approximately 30 amino acid residues found in a number of proteins that transport or detoxify heavy metals, for example, the CPx-type heavy metal ATPases and copper chaperones. HMA domain...; Region: HMA; cd00371 441771001471 metal-binding site [ion binding] 441771001472 E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122 441771001473 haloacid dehalogenase-like hydrolase; Region: HAD; pfam12710 441771001474 Soluble P-type ATPase [General function prediction only]; Region: COG4087 441771001475 RecT family; Region: RecT; cl04285 441771001476 Domain of unknown function (DUF2935); Region: DUF2935; pfam11155 441771001477 Domain of unknown function (DUF2935); Region: DUF2935; pfam11155 441771001478 NYN ribonuclease and ATPase of PhoH family domains [General function prediction only]; Region: COG1875 441771001479 PIN domain of bacterial Smg6-like homologs with PhoH-like ATPase domains; Region: PIN_PhoHL-ATPase; cd09883 441771001480 putative active site [active] 441771001481 PhoH-like protein; Region: PhoH; pfam02562 441771001482 Exopolysaccharide biosynthesis protein related to N-acetylglucosamine-1-phosphodiester alpha-N-acetylglucosaminidase [Carbohydrate transport and metabolism]; Region: EpsL; COG4632 441771001483 Predicted periplasmic protein (DUF2233); Region: DUF2233; pfam09992 441771001484 bacteriocin protoxin, streptolysin S family; Region: streptolysinS; TIGR03602 441771001485 This family is the oxydase domain of NRPS (non-ribosomal peptide synthetase) and other proteins that modify polypeptides by cyclizing a thioester to form a ring. These include epoB, part of the epothilone biosynthesis pathway; tubD, part of the tubulysin...; Region: mcbC-like_oxidoreductase; cd02142 441771001486 putative FMN binding site [chemical binding]; other site 441771001487 NADPH bind site [chemical binding]; other site 441771001488 thiazole/oxazole-forming peptide maturase, SagC family component; Region: cyclo_dehy_ocin; TIGR03603 441771001489 bacteriocin biosynthesis cyclodehydratase domain; Region: cyclo_dehyd_2; TIGR03882 441771001490 thiazole/oxazole-forming peptide maturase, SagD family component; Region: TOMM_cyclo_SagD; TIGR03604 441771001491 CAAX protease self-immunity; Region: Abi; pfam02517 441771001492 ABC-type multidrug transport system, ATPase component [Defense mechanisms]; Region: CcmA; COG1131 441771001493 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 441771001494 Walker A/P-loop; other site 441771001495 ATP binding site [chemical binding]; other site 441771001496 Q-loop/lid; other site 441771001497 ABC transporter signature motif; other site 441771001498 Walker B; other site 441771001499 D-loop; other site 441771001500 H-loop/switch region; other site 441771001501 ABC-2 family transporter protein; Region: ABC2_membrane_3; pfam12698 441771001502 ABC-2 type transporter; Region: ABC2_membrane; pfam01061 441771001503 ABC-type Na+ efflux pump, permease component [Energy production and conversion / Inorganic ion transport and metabolism]; Region: NatB; COG1668 441771001504 YhgE/Pip N-terminal domain; Region: pip_yhgE_Nterm; cl19580 441771001505 ABC-2 type transporter; Region: ABC2_membrane; pfam01061 441771001506 Uncharacterized homologs of Site-2 protease (S2P), zinc metalloproteases (MEROPS family M50) which cleave transmembrane domains of substrate proteins, regulating intramembrane proteolysis (RIP) of diverse signal transduction mechanisms. Members of the...; Region: S2P-M50_like_1; cd06158 441771001507 Peptidase family M50; Region: Peptidase_M50; pfam02163 441771001508 active site 441771001509 putative substrate binding region [chemical binding]; other site 441771001510 Citrate transporter; Region: CitMHS; pfam03600 441771001511 Permease P (pink-eyed dilution). Mutations in the human melanosomal P gene were responsible for classic phenotype of oculocutaneous albinism type 2 (OCA2). Although the precise function of the P protein is unknown, it was predicted to regulate the...; Region: P_permease; cd01116 441771001512 transmembrane helices; other site 441771001513 tRNA (guanine-N(7)-)-methyltransferase; Reviewed; Region: trmB; PRK00121 441771001514 Protein of unknown function (DUF3892); Region: DUF3892; pfam13031 441771001515 Peroxiredoxin (PRX) family, Atypical 2-cys PRX subfamily; composed of PRXs containing peroxidatic and resolving cysteines, similar to the homodimeric thiol specific antioxidant (TSA) protein also known as TRX-dependent thiol peroxidase (Tpx). Tpx is a...; Region: PRX_Atyp2cys; cd03014 441771001516 dimer interface [polypeptide binding]; other site 441771001517 catalytic triad [active] 441771001518 peroxidatic and resolving cysteines [active] 441771001519 3-ketoacyl-(acyl-carrier-protein) reductase; Provisional; Region: fabG; PRK05565 441771001520 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 441771001521 NAD(P) binding site [chemical binding]; other site 441771001522 active site 441771001523 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 441771001524 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 441771001525 active site 441771001526 phosphorylation site [posttranslational modification] 441771001527 intermolecular recognition site; other site 441771001528 dimerization interface [polypeptide binding]; other site 441771001529 Class III nucleotidyl cyclases; Region: Nucleotidyl_cyc_III; cl11967 441771001530 CHAP domain; Region: CHAP; pfam05257 441771001531 Bacterial SH3 domain; Region: SH3_3; pfam08239 441771001532 Bacterial SH3 domain; Region: SH3_3; pfam08239 441771001533 Bacterial SH3 domain; Region: SH3_3; pfam08239 441771001534 Bacterial SH3 domain; Region: SH3_3; pfam08239 441771001535 Nucleolar protein 12 (25kDa); Region: Nop25; pfam09805 441771001536 ATP synthase archaeal, H subunit; Region: AhaH; TIGR02926 441771001537 Double-stranded DNA-binding domain; Region: dsDNA_bind; cl00928 441771001538 Cell wall-associated hydrolases (invasion-associated proteins) [Cell envelope biogenesis, outer membrane]; Region: Spr; COG0791 441771001539 NlpC/P60 family; Region: NLPC_P60; pfam00877 441771001540 Lysophospholipase [Lipid metabolism]; Region: PldB; COG2267 441771001541 Putative lysophospholipase; Region: Hydrolase_4; pfam12146 441771001542 Prolyl oligopeptidase family; Region: Peptidase_S9; cl19144 441771001543 PAS fold; Region: PAS_4; pfam08448 441771001544 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 441771001545 active site 441771001546 phosphorylation site [posttranslational modification] 441771001547 intermolecular recognition site; other site 441771001548 dimerization interface [polypeptide binding]; other site 441771001549 Hpt domain; Region: Hpt; pfam01627 441771001550 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 441771001551 Zn2+ binding site [ion binding]; other site 441771001552 Mg2+ binding site [ion binding]; other site 441771001553 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 441771001554 dimerization interface [polypeptide binding]; other site 441771001555 Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer); Region: MA; smart00283 441771001556 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cl19050 441771001557 dimer interface [polypeptide binding]; other site 441771001558 putative CheW interface [polypeptide binding]; other site 441771001559 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 441771001560 active site 441771001561 phosphorylation site [posttranslational modification] 441771001562 intermolecular recognition site; other site 441771001563 dimerization interface [polypeptide binding]; other site 441771001564 Uncharacterized conserved protein (DUF2294); Region: DUF2294; cl02390 441771001565 seryl-tRNA synthetase; Provisional; Region: PRK05431 441771001566 Prefoldin is a hexameric molecular chaperone complex, found in both eukaryotes and archaea, that binds and stabilizes newly synthesized polypeptides allowing them to fold correctly. The complex contains two alpha and four beta subunits, the two subunits...; Region: Prefoldin; cd00890 441771001567 Class II tRNA amino-acyl synthetase-like catalytic core domain. Class II amino acyl-tRNA synthetases (aaRS) share a common fold and generally attach an amino acid to the 3' OH of ribose of the appropriate tRNA. PheRS is an exception in that it...; Region: class_II_aaRS-like_core; cl00268 441771001568 motif 1; other site 441771001569 dimer interface [polypeptide binding]; other site 441771001570 active site 441771001571 motif 2; other site 441771001572 motif 3; other site 441771001573 Rad3-related DNA helicases [Transcription / DNA replication, recombination, and repair]; Region: DinG; COG1199 441771001574 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cl17251 441771001575 DEAD_2; Region: DEAD_2; pfam06733 441771001576 Helicase C-terminal domain; Region: Helicase_C_2; pfam13307 441771001577 Predicted transcriptional regulators [Transcription]; Region: COG1725 441771001578 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 441771001579 DNA-binding site [nucleotide binding]; DNA binding site 441771001580 TrkA-C domain; Region: TrkA_C; pfam02080 441771001581 N(5)-(carboxyethyl)ornithine synthase; Region: ceo_syn; cd12181 441771001582 putative active site [active] 441771001583 putative ligand binding site [chemical binding]; other site 441771001584 putative NAD(P) binding site [chemical binding]; other site 441771001585 Firmicute fructose-1,6-bisphosphatase; Region: FBPase_2; pfam06874 441771001586 Hemerythrin; Region: Hemerythrin; cd12107 441771001587 Fe binding site [ion binding]; other site 441771001588 Superoxide dismutase [Inorganic ion transport and metabolism]; Region: SodA; COG0605 441771001589 Iron/manganese superoxide dismutases, C-terminal domain; Region: Sod_Fe_C; pfam02777 441771001590 Metal-dependent hydrolases of the beta-lactamase superfamily II [General function prediction only]; Region: COG1237 441771001591 Amino acid permease; Region: AA_permease_2; pfam13520 441771001592 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 441771001593 non-specific DNA binding site [nucleotide binding]; other site 441771001594 salt bridge; other site 441771001595 sequence-specific DNA binding site [nucleotide binding]; other site 441771001596 Acetyltransferase (GNAT) domain; Region: Acetyltransf_10; pfam13673 441771001597 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 441771001598 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl17182 441771001599 Coenzyme A binding pocket [chemical binding]; other site 441771001600 BFD-like [2Fe-2S] binding domain; Region: Fer2_BFD; pfam04324 441771001601 Carbon starvation protein, predicted membrane protein [Signal transduction mechanisms]; Region: CstA; COG1966 441771001602 Carbon starvation protein CstA; Region: CstA; pfam02554 441771001603 C-terminal domain on CstA (DUF4161); Region: DUF4161; pfam13722 441771001604 Cell wall-active antibiotics response protein (DUF2154); Region: DUF2154; pfam09922 441771001605 Cache domain; Region: Cache_1; pfam02743 441771001606 HAMP domain; Region: HAMP; pfam00672 441771001607 Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer); Region: MA; smart00283 441771001608 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cl19050 441771001609 dimer interface [polypeptide binding]; other site 441771001610 putative CheW interface [polypeptide binding]; other site 441771001611 large-conductance mechanosensitive channel; Reviewed; Region: mscL; PRK00567 441771001612 Thiamine transporter protein (Thia_YuaJ); Region: Thia_YuaJ; pfam09515 441771001613 SEC-C motif; Region: SEC-C; pfam02810 441771001614 Predicted transcriptional regulators [Transcription]; Region: COG1725 441771001615 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 441771001616 DNA-binding site [nucleotide binding]; DNA binding site 441771001617 gallidermin-class lantibiotic protection ABC transporter, ATP-binding subunit; Region: galliderm_ABC; TIGR03740 441771001618 ATP-binding cassette domain of the drug resistance transporter and related proteins, subfamily A; Region: ABC_DR_subfamily_A; cd03230 441771001619 Walker A/P-loop; other site 441771001620 ATP binding site [chemical binding]; other site 441771001621 Q-loop/lid; other site 441771001622 ABC transporter signature motif; other site 441771001623 Walker B; other site 441771001624 D-loop; other site 441771001625 H-loop/switch region; other site 441771001626 ABC-type spermidine/putrescine transport systems, ATPase components [Amino acid transport and metabolism]; Region: PotA; COG3842 441771001627 ATP-binding cassette domain of the polyamine transporter; Region: ABC_PotA_N; cd03300 441771001628 Walker A/P-loop; other site 441771001629 ATP binding site [chemical binding]; other site 441771001630 Q-loop/lid; other site 441771001631 ABC transporter signature motif; other site 441771001632 Walker B; other site 441771001633 D-loop; other site 441771001634 H-loop/switch region; other site 441771001635 TOBE domain; Region: TOBE_2; pfam08402 441771001636 sulfate transport protein; Provisional; Region: cysT; CHL00187 441771001637 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 441771001638 dimer interface [polypeptide binding]; other site 441771001639 conserved gate region; other site 441771001640 putative PBP binding loops; other site 441771001641 ABC-ATPase subunit interface; other site 441771001642 ABC-type spermidine/putrescine transport system, permease component II [Amino acid transport and metabolism]; Region: PotC; COG1177 441771001643 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 441771001644 dimer interface [polypeptide binding]; other site 441771001645 conserved gate region; other site 441771001646 putative PBP binding loops; other site 441771001647 ABC-ATPase subunit interface; other site 441771001648 Spermidine/putrescine-binding periplasmic protein [Amino acid transport and metabolism]; Region: PotD; COG0687 441771001649 AraC-like ligand binding domain; Region: AraC_binding; pfam02311 441771001650 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 441771001651 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 441771001652 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 441771001653 Sodium:dicarboxylate symporter family; Region: SDF; pfam00375 441771001654 Predicted HD superfamily hydrolase [General function prediction only]; Region: COG1418 441771001655 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 441771001656 Zn2+ binding site [ion binding]; other site 441771001657 Mg2+ binding site [ion binding]; other site 441771001658 ribosomal-protein-alanine acetyltransferase; Region: rimI; TIGR01575 441771001659 CAAX protease self-immunity; Region: Abi; pfam02517 441771001660 Pentapeptide repeats containing protein [Function unknown]; Region: COG1357 441771001661 Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805 441771001662 The tRNA binding domain is also known as the Myf domain in literature. This domain is found in a diverse collection of tRNA binding proteins, including prokaryotic phenylalanyl tRNA synthetases (PheRS), methionyl-tRNA synthetases (MetRS), human...; Region: tRNA_bindingDomain; cl00320 441771001663 putative tRNA-binding site [nucleotide binding]; other site 441771001664 signal peptidase I, bacterial type; Region: sigpep_I_bact; TIGR02227 441771001665 The S26 Type I signal peptidase (SPase; LepB; leader peptidase B; leader peptidase I; EC 3.4.21.89) family members are essential membrane-bound serine proteases that function to cleave the amino-terminal signal peptide extension from proteins that are...; Region: S26_SPase_I; cd06530 441771001666 Catalytic site [active] 441771001667 The S24, S26 LexA/signal peptidase superfamily contains LexA-related and type I signal peptidase families. The S24 LexA protein domains include: the lambda repressor CI/C2 family and related bacterial prophage repressor proteins; LexA (EC 3.4.21.88), the...; Region: Peptidase_S24_S26; cl10465 441771001668 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 441771001669 Response regulator of the LytR/AlgR family [Transcription / Signal transduction mechanisms]; Region: LytT; COG3279 441771001670 active site 441771001671 phosphorylation site [posttranslational modification] 441771001672 intermolecular recognition site; other site 441771001673 dimerization interface [polypeptide binding]; other site 441771001674 LytTr DNA-binding domain; Region: LytTR; smart00850 441771001675 Cys-rich peptide, Clo7bot family; Region: Clo7Bot_mod_Cys; TIGR04333 441771001676 Cys-rich peptide, Clo7bot family; Region: Clo7Bot_mod_Cys; TIGR04333 441771001677 radical SAM/SPASM domain Clo7bot peptide maturase; Region: rSAM_Clo7bot; TIGR04334 441771001678 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 441771001679 FeS/SAM binding site; other site 441771001680 radical SAM additional 4Fe4S-binding SPASM domain; Region: rSAM_more_4Fe4S; TIGR04085 441771001681 Peptidase MA superfamily; Region: Peptidase_MA_2; pfam13485 441771001682 Zn binding site [ion binding]; other site 441771001683 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 441771001684 Coenzyme A binding pocket [chemical binding]; other site 441771001685 ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132 441771001686 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 441771001687 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 441771001688 Walker A/P-loop; other site 441771001689 ATP binding site [chemical binding]; other site 441771001690 Q-loop/lid; other site 441771001691 ABC transporter signature motif; other site 441771001692 Walker B; other site 441771001693 D-loop; other site 441771001694 H-loop/switch region; other site 441771001695 Acetyltransferase (GNAT) family; Region: Acetyltransf_1; pfam00583 441771001696 ABC-type transport system, involved in lipoprotein release, permease component [Cell envelope biogenesis, outer membrane]; Region: LolE; COG4591 441771001697 MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704 441771001698 FtsX-like permease family; Region: FtsX; pfam02687 441771001699 MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704 441771001700 ABC-type antimicrobial peptide transport system, permease component [Defense mechanisms]; Region: SalY; COG0577 441771001701 FtsX-like permease family; Region: FtsX; pfam02687 441771001702 ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136 441771001703 ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255 441771001704 Walker A/P-loop; other site 441771001705 ATP binding site [chemical binding]; other site 441771001706 Q-loop/lid; other site 441771001707 ABC transporter signature motif; other site 441771001708 Walker B; other site 441771001709 D-loop; other site 441771001710 H-loop/switch region; other site 441771001711 EDD domain protein, DegV family; Region: DegV; TIGR00762 441771001712 hypothetical protein; Provisional; Region: PRK04164 441771001713 Uncharacterized protein conserved in bacteria (DUF2179); Region: DUF2179; cl19873 441771001714 Phosphoglycerol transferase and related proteins, alkaline phosphatase superfamily [Cell envelope biogenesis, outer membrane]; Region: MdoB; COG1368 441771001715 Sulfatase; Region: Sulfatase; pfam00884 441771001716 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 441771001717 psp operon transcriptional activator PspF; Region: phageshock_pspF; TIGR02974 441771001718 Walker A motif; other site 441771001719 ATP binding site [chemical binding]; other site 441771001720 Walker B motif; other site 441771001721 arginine finger; other site 441771001722 Bacterial regulatory protein, Fis family; Region: HTH_8; pfam02954 441771001723 Nucleoside permease [Nucleotide transport and metabolism]; Region: NupC; COG1972 441771001724 Na+ dependent nucleoside transporter N-terminus; Region: Nucleos_tra2_N; pfam01773 441771001725 Nucleoside recognition; Region: Gate; pfam07670 441771001726 Na+ dependent nucleoside transporter C-terminus; Region: Nucleos_tra2_C; pfam07662 441771001727 asparaginyl-tRNA synthetase; Validated; Region: asnC; PRK03932 441771001728 EcAsnRS_like_N: N-terminal, anticodon recognition domain of the type found in Escherichia coli asparaginyl-tRNA synthetase (AsnRS) and, in Arabidopsis thaliana and Saccharomyces cerevisiae mitochondrial (mt) AsnRS. This domain is a beta-barrel domain (OB...; Region: EcAsnRS_like_N; cd04318 441771001729 putative dimer interface [polypeptide binding]; other site 441771001730 putative anticodon binding site; other site 441771001731 Asx tRNA synthetase (AspRS/AsnRS) class II core domain. Assignment to class II aminoacyl-tRNA synthetases (aaRS) based upon its structure and the presence of three characteristic sequence motifs in the core domain. This family includes AsnRS as well as...; Region: AsxRS_core; cd00776 441771001732 homodimer interface [polypeptide binding]; other site 441771001733 motif 1; other site 441771001734 motif 2; other site 441771001735 active site 441771001736 motif 3; other site 441771001737 Predicted transcriptional regulators [Transcription]; Region: COG1695 441771001738 Protein of unknown function (DUF2812); Region: DUF2812; pfam11193 441771001739 LytTr DNA-binding domain; Region: LytTR; smart00850 441771001740 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 441771001741 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 441771001742 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 441771001743 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3708 441771001744 CAAX protease self-immunity; Region: Abi; pfam02517 441771001745 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 441771001746 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 441771001747 non-specific DNA binding site [nucleotide binding]; other site 441771001748 salt bridge; other site 441771001749 sequence-specific DNA binding site [nucleotide binding]; other site 441771001750 Bacterial Ig-like domain (group 4); Region: Big_4; pfam07532 441771001751 Bacterial Ig-like domain (group 4); Region: Big_4; pfam07532 441771001752 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 441771001753 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 441771001754 active site 441771001755 phosphorylation site [posttranslational modification] 441771001756 intermolecular recognition site; other site 441771001757 dimerization interface [polypeptide binding]; other site 441771001758 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 441771001759 DNA binding site [nucleotide binding] 441771001760 D-alanyl-D-alanine carboxypeptidase [Cell envelope biogenesis, outer membrane]; Region: VanY; COG1876 441771001761 D-alanyl-D-alanine carboxypeptidase; Region: VanY; pfam02557 441771001762 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 441771001763 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 441771001764 active site 441771001765 phosphorylation site [posttranslational modification] 441771001766 intermolecular recognition site; other site 441771001767 dimerization interface [polypeptide binding]; other site 441771001768 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 441771001769 DNA binding site [nucleotide binding] 441771001770 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 441771001771 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 441771001772 dimer interface [polypeptide binding]; other site 441771001773 phosphorylation site [posttranslational modification] 441771001774 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 441771001775 ATP binding site [chemical binding]; other site 441771001776 Mg2+ binding site [ion binding]; other site 441771001777 G-X-G motif; other site 441771001778 Phosphotransferase system, EIIC; Region: PTS_EIIC_2; pfam13303 441771001779 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 441771001780 active site 441771001781 phosphorylation site [posttranslational modification] 441771001782 intermolecular recognition site; other site 441771001783 dimerization interface [polypeptide binding]; other site 441771001784 YcbB domain; Region: YcbB; pfam08664 441771001785 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 441771001786 ATP binding site [chemical binding]; other site 441771001787 Mg2+ binding site [ion binding]; other site 441771001788 G-X-G motif; other site 441771001789 rod shape-determining protein RodA; Region: rodA_shape; TIGR02210 441771001790 Cyclopropane fatty acid synthase and related methyltransferases [Cell envelope biogenesis, outer membrane]; Region: Cfa; COG2230 441771001791 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl17173 441771001792 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 441771001793 S-adenosylmethionine binding site [chemical binding]; other site 441771001794 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 441771001795 dimerization interface [polypeptide binding]; other site 441771001796 putative DNA binding site [nucleotide binding]; other site 441771001797 putative Zn2+ binding site [ion binding]; other site 441771001798 ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132 441771001799 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 441771001800 ATP-binding cassette domain of multidrug resistance protein-like transporters; Region: ABCC_MRP_Like; cd03228 441771001801 Walker A/P-loop; other site 441771001802 ATP binding site [chemical binding]; other site 441771001803 Q-loop/lid; other site 441771001804 ABC transporter signature motif; other site 441771001805 Walker B; other site 441771001806 D-loop; other site 441771001807 H-loop/switch region; other site 441771001808 Chloramphenicol acetyltransferase; Region: CAT; smart01059 441771001809 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 441771001810 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 441771001811 Acetyltransferase (GNAT) domain; Region: Acetyltransf_3; pfam13302 441771001812 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 441771001813 Coenzyme A binding pocket [chemical binding]; other site 441771001814 tRNA-binding-domain-containing CsaA-like proteins. CsaA is a molecular chaperone with export related activities. CsaA has a putative tRNA binding activity. The functional unit of CsaA is a homodimer and this domain acts as a dimerization domain; Region: tRNA_bind_CsaA; cd02798 441771001815 dimer interface [polypeptide binding]; other site 441771001816 putative tRNA-binding site [nucleotide binding]; other site 441771001817 AraC-like ligand binding domain; Region: AraC_binding; pfam02311 441771001818 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 441771001819 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 441771001820 DNA-binding transcriptional repressor PuuR; Provisional; Region: PRK09943 441771001821 non-specific DNA binding site [nucleotide binding]; other site 441771001822 salt bridge; other site 441771001823 sequence-specific DNA binding site [nucleotide binding]; other site 441771001824 Cupin domain; Region: Cupin_2; pfam07883 441771001825 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 441771001826 Zn2+ binding site [ion binding]; other site 441771001827 Mg2+ binding site [ion binding]; other site 441771001828 ABC-type Na+ transport system, ATPase component [Energy production and conversion / Inorganic ion transport and metabolism]; Region: NatA; COG4555 441771001829 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 441771001830 Q-loop/lid; other site 441771001831 ABC transporter signature motif; other site 441771001832 Response regulator of the LytR/AlgR family [Transcription / Signal transduction mechanisms]; Region: LytT; COG3279 441771001833 Walker B; other site 441771001834 D-loop; other site 441771001835 H-loop/switch region; other site 441771001836 LytTr DNA-binding domain; Region: LytTR; smart00850 441771001837 ABC-type Na+ transport system, ATPase component [Energy production and conversion / Inorganic ion transport and metabolism]; Region: NatA; COG4555 441771001838 ATP-binding cassette domain of the drug resistance transporter and related proteins, subfamily A; Region: ABC_DR_subfamily_A; cd03230 441771001839 Walker A/P-loop; other site 441771001840 ATP binding site [chemical binding]; other site 441771001841 Q-loop/lid; other site 441771001842 ABC transporter signature motif; other site 441771001843 Walker B; other site 441771001844 D-loop; other site 441771001845 H-loop/switch region; other site 441771001846 allantoate amidohydrolase; Reviewed; Region: PRK09290 441771001847 M20 Peptidase beta-alanine synthase, an amidohydrolase; Region: M20_bAS; cd03884 441771001848 active site 441771001849 metal binding site [ion binding]; metal-binding site 441771001850 dimer interface [polypeptide binding]; other site 441771001851 DNA-binding domain of DNA mismatch repair MUTS family; Region: MUTSd; smart00533 441771001852 MutS domain III; Region: MutS_III; pfam05192 441771001853 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 441771001854 Walker A/P-loop; other site 441771001855 ATP binding site [chemical binding]; other site 441771001856 Q-loop/lid; other site 441771001857 ABC transporter signature motif; other site 441771001858 Walker B; other site 441771001859 D-loop; other site 441771001860 H-loop/switch region; other site 441771001861 riboflavin kinase/FMN adenylyltransferase; Region: ribF; TIGR00083 441771001862 Transposon-encoded protein TnpV; Region: TnpV; pfam14198 441771001863 Pyridoxamine 5'-phosphate oxidase; Region: Pyridox_ox_2; cl17869 441771001864 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2832 441771001865 Predicted flavin-nucleotide-binding protein [General function prediction only]; Region: COG3467 441771001866 endonuclease III; includes endonuclease III (DNA-(apurinic or apyrimidinic site) lyase), alkylbase DNA glycosidases (Alka-family) and other DNA glycosidases; Region: ENDO3c; cl19066 441771001867 minor groove reading motif; other site 441771001868 Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain (MocR family) and their eukaryotic orthologs [Transcription / Amino acid transport and metabolism]; Region: ARO8; COG1167 441771001869 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 441771001870 DNA-binding site [nucleotide binding]; DNA binding site 441771001871 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 441771001872 pyridoxal 5'-phosphate binding site [chemical binding]; other site 441771001873 homodimer interface [polypeptide binding]; other site 441771001874 catalytic residue [active] 441771001875 Antibiotic biosynthesis monooxygenase; Region: ABM; cl10022 441771001876 Pyridoxamine 5'-phosphate oxidase; Region: Pyridox_ox_2; cl17869 441771001877 ATP-dependent RNA helicase SrmB; Provisional; Region: PRK11192 441771001878 DEAD-box helicases. A diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker B motif; Region: DEADc; cd00268 441771001879 ATP binding site [chemical binding]; other site 441771001880 Mg++ binding site [ion binding]; other site 441771001881 motif III; other site 441771001882 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 441771001883 nucleotide binding region [chemical binding]; other site 441771001884 ATP-binding site [chemical binding]; other site 441771001885 Uncharacterized family of ferritin-like proteins found in archaea and bacteria; Region: Ferritin_like_AB; cd01045 441771001886 diiron binding motif [ion binding]; other site 441771001887 Transcriptional regulators [Transcription]; Region: MarR; COG1846 441771001888 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cl17220 441771001889 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 441771001890 Major Facilitator Superfamily; Region: MFS_1; pfam07690 441771001891 putative substrate translocation pore; other site 441771001892 F420-0:Gamma-glutamyl ligase; Region: F420_ligase; pfam01996 441771001893 Transcriptional regulator [Transcription]; Region: LysR; COG0583 441771001894 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 441771001895 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cd05466 441771001896 dimerization interface [polypeptide binding]; other site 441771001897 Predicted AAA-ATPase; Region: AAA-ATPase_like; pfam09820 441771001898 Protein of unknown function (DUF1703); Region: DUF1703; pfam08011 441771001899 Protein of unknown function N-terminus (DUF3323); Region: DUF3323; pfam11796 441771001900 Protein of unknown function C-terminus (DUF2399); Region: DUF2399; pfam09664 441771001901 YdcF-like. YdcF-like is a large family of mainly bacterial proteins, with a few members found in fungi, plants, and archaea. Escherichia coli YdcF has been shown to bind S-adenosyl-L-methionine (AdoMet), but a biochemical function has not been...; Region: YdcF-like; cd06259 441771001902 putative active site [active] 441771001903 N-terminal putative catalytic domain of uncharacterized prokaryotic and archeal HKD family nucleases fused to a DEAD/DEAH box helicase domain; Region: PLDc_N_DEXD_b2; cd09204 441771001904 PLD-like domain; Region: PLDc_2; pfam13091 441771001905 putative homodimer interface [polypeptide binding]; other site 441771001906 putative active site [active] 441771001907 catalytic site [active] 441771001908 DNA or RNA helicases of superfamily II [Transcription / DNA replication, recombination, and repair]; Region: SSL2; COG1061 441771001909 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 441771001910 ATP binding site [chemical binding]; other site 441771001911 putative Mg++ binding site [ion binding]; other site 441771001912 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 441771001913 nucleotide binding region [chemical binding]; other site 441771001914 ATP-binding site [chemical binding]; other site 441771001915 Domain of unknown function (DUF3427); Region: DUF3427; pfam11907 441771001916 The MutT pyrophosphohydrolase is a prototypical Nudix hydrolase that catalyzes the hydrolysis of nucleoside and deoxynucleoside triphosphates (NTPs and dNTPs) by substitution at a beta-phosphorus to yield a nucleotide monophosphate (NMP) and inorganic...; Region: MutT_pyrophosphohydrolase; cd03425 441771001917 active site 441771001918 8-oxo-dGMP binding site [chemical binding]; other site 441771001919 nudix motif; other site 441771001920 metal binding site [ion binding]; metal-binding site 441771001921 transcriptional antiterminator BglG; Provisional; Region: PRK09772 441771001922 CAT RNA binding domain; Region: CAT_RBD; smart01061 441771001923 PRD domain; Region: PRD; pfam00874 441771001924 PRD domain; Region: PRD; pfam00874 441771001925 PTS system, beta-glucoside-specific IIABC component; Region: PTS-II-ABC-beta; TIGR01995 441771001926 PTS_IIB, PTS system, glucose/sucrose specific IIB subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIB_glc; cd00212 441771001927 active site turn [active] 441771001928 phosphorylation site [posttranslational modification] 441771001929 Phosphotransferase system IIC components, glucose/maltose/N-acetylglucosamine-specific [Carbohydrate transport and metabolism]; Region: PtsG; COG1263 441771001930 Phosphotransferase system IIA components [Carbohydrate transport and metabolism]; Region: NagE; COG2190 441771001931 HPr interaction site; other site 441771001932 glycerol kinase (GK) interaction site [polypeptide binding]; other site 441771001933 active site 441771001934 phosphorylation site [posttranslational modification] 441771001935 Predicted metal-dependent phosphoesterases (PHP family) [General function prediction only]; Region: COG0613 441771001936 Polymerase and Histidinol Phosphatase domain of Histidinol phosphate phosphatase (HisPPase) AMP bound; Region: PHP_HisPPase_AMP; cd07438 441771001937 active site 441771001938 cAMP-binding proteins - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases [Signal transduction mechanisms]; Region: Crp; COG0664 441771001939 effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038 441771001940 ligand binding site [chemical binding]; other site 441771001941 flexible hinge region; other site 441771001942 helix_turn_helix, cAMP Regulatory protein C-terminus; DNA binding domain of prokaryotic regulatory proteins belonging to the catabolite activator protein family; Region: HTH_CRP; cd00092 441771001943 putative switch regulator; other site 441771001944 non-specific DNA interactions [nucleotide binding]; other site 441771001945 DNA binding site [nucleotide binding] 441771001946 sequence specific DNA binding site [nucleotide binding]; other site 441771001947 putative cAMP binding site [chemical binding]; other site 441771001948 Uncharacterized flavoproteins [Energy production and conversion]; Region: FpaA; COG0426 441771001949 Metallo-beta-lactamase superfamily; Region: Lactamase_B; smart00849 441771001950 NADPH-dependent FMN reductase; Region: FMN_red; cl00438 441771001951 Domain of Unknown function (DUF542); Region: ScdA_N; pfam04405 441771001952 iron-sulfur cluster repair di-iron protein; Region: FeS_repair_RIC; TIGR03652 441771001953 Hemerythrin HHE cation binding domain; Region: Hemerythrin; pfam01814 441771001954 Family of unknown function (DUF438); Region: DUF438; pfam04282 441771001955 Hemerythrin HHE cation binding domain; Region: Hemerythrin; pfam01814 441771001956 Na+/glutamate symporter [Amino acid transport and metabolism]; Region: GltS; COG0786 441771001957 Metallo-beta-lactamase superfamily; Region: Lactamase_B; smart00849 441771001958 Transmembrane subunit (TM) of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which are involved in the uptake of branched-chain amino acids (AAs), as well as TMs of transporters involved in the uptake of...; Region: TM_PBP1_branched-chain-AA_like; cd06574 441771001959 TM-ABC transporter signature motif; other site 441771001960 ABC-type uncharacterized transport system, ATPase component [General function prediction only]; Region: PhnK; COG1101 441771001961 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 441771001962 Walker A/P-loop; other site 441771001963 ATP binding site [chemical binding]; other site 441771001964 Q-loop/lid; other site 441771001965 ABC transporter signature motif; other site 441771001966 Walker B; other site 441771001967 D-loop; other site 441771001968 H-loop/switch region; other site 441771001969 Type I periplasmic ligand-binding domain of uncharacterized ABC-type transport systems that are predicted to be involved in the uptake of amino acids, peptides, or inorganic ions; Region: PBP1_ABC_uncharacterized_transporter; cd06325 441771001970 Periplasmic binding protein domain; Region: Peripla_BP_4; pfam13407 441771001971 zinc binding site [ion binding]; other site 441771001972 putative ligand binding site [chemical binding]; other site 441771001973 Protein Kinases, catalytic domain; Region: PKc_like; cl09925 441771001974 Serine/threonine protein kinase [General function prediction only / Signal transduction mechanisms / Transcription / DNA replication, recombination, and repair]; Region: SPS1; COG0515 441771001975 RNA polymerase factor sigma-70; Validated; Region: PRK06811 441771001976 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 441771001977 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cl17257 441771001978 Dihydrouridine synthase-like (DUS-like) FMN-binding domain. Members of this family catalyze the reduction of the 5,6-double bond of a uridine residue on tRNA. Dihydrouridine modification of tRNA is widely observed in prokaryotes and eukaryotes, and also...; Region: DUS_like_FMN; cd02801 441771001979 FMN binding site [chemical binding]; other site 441771001980 active site 441771001981 catalytic residues [active] 441771001982 substrate binding site [chemical binding]; other site 441771001983 Transcription elongation factor, N-terminal; Region: GreA_GreB_N; pfam03449 441771001984 transcription elongation factor GreA; Region: greA; TIGR01462 441771001985 Transcription elongation factor, GreA/GreB, C-term; Region: GreA_GreB; pfam01272 441771001986 Outer spore coat protein E (CotE); Region: CotE; pfam10628 441771001987 Type I restriction-modification system methyltransferase subunit [Defense mechanisms]; Region: HsdM; COG0286 441771001988 HsdM N-terminal domain; Region: HsdM_N; pfam12161 441771001989 Methyltransferase domain; Region: Methyltransf_26; pfam13659 441771001990 Restriction endonuclease S subunits [Defense mechanisms]; Region: HsdS; COG0732 441771001991 Type I restriction modification DNA specificity domain; Region: Methylase_S; pfam01420 441771001992 Type I restriction modification DNA specificity domain; Region: Methylase_S; pfam01420 441771001993 Domain of unknown function (DUF4351); Region: DUF4351; pfam14261 441771001994 Domain of unknown function (DUF4145); Region: DUF4145; pfam13643 441771001995 Type I site-specific restriction-modification system, R (restriction) subunit and related helicases [Defense mechanisms]; Region: HsdR; COG4096 441771001996 Type I restriction enzyme R protein N terminus (HSDR_N); Region: HSDR_N; pfam04313 441771001997 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 441771001998 ATP binding site [chemical binding]; other site 441771001999 putative Mg++ binding site [ion binding]; other site 441771002000 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 441771002001 nucleotide binding region [chemical binding]; other site 441771002002 ATP-binding site [chemical binding]; other site 441771002003 EcoEI R protein C-terminal; Region: EcoEI_R_C; pfam08463 441771002004 ATP-dependent DNA helicase PcrA; Region: pcrA; TIGR01073 441771002005 Part of AAA domain; Region: AAA_19; pfam13245 441771002006 UvrD-like helicase C-terminal domain; Region: UvrD_C_2; pfam13538 441771002007 Hemimethylated DNA-binding protein YccV like; Region: YccV-like; cl01548 441771002008 Arginine and glutamate-rich 1; Region: ARGLU; pfam15346 441771002009 Apolipophorin-III and similar insect proteins; Region: ApoLp-III_like; cl19113 441771002010 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 441771002011 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 441771002012 ABC-type Fe3+-hydroxamate transport system, periplasmic component [Inorganic ion transport and metabolism]; Region: FepB; COG0614 441771002013 Helical backbone metal receptor (TroA-like domain). These proteins have been shown to function in the ABC transport of ferric siderophores and metal ions such as Mn2+, Fe3+, Cu2+ and/or Zn2+. Their ligand binding site is formed in the interface between...; Region: TroA-like; cl00262 441771002014 intersubunit interface [polypeptide binding]; other site 441771002015 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550 441771002016 ABC-ATPase subunit interface; other site 441771002017 dimer interface [polypeptide binding]; other site 441771002018 putative PBP binding regions; other site 441771002019 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550 441771002020 ABC-ATPase subunit interface; other site 441771002021 dimer interface [polypeptide binding]; other site 441771002022 putative PBP binding regions; other site 441771002023 ABC-type cobalamin/Fe3+-siderophores transport systems, ATPase components [Inorganic ion transport and metabolism / Coenzyme metabolism]; Region: FepC; COG1120 441771002024 ATP-binding component of iron-siderophores, vitamin B12 and hemin transporters and related proteins; Region: ABC_Iron-Siderophores_B12_Hemin; cd03214 441771002025 Walker A/P-loop; other site 441771002026 ATP binding site [chemical binding]; other site 441771002027 Q-loop/lid; other site 441771002028 ABC transporter signature motif; other site 441771002029 Walker B; other site 441771002030 D-loop; other site 441771002031 H-loop/switch region; other site 441771002032 The Fer4_NifH superfamily contains a variety of proteins which share a common ATP-binding domain. Functionally, proteins in this superfamily use the energy from hydrolysis of NTP to transfer electron or ion; Region: Fer4_NifH; cl17203 441771002033 4Fe-4S iron sulfur cluster binding proteins, NifH/frxC family; Region: Fer4_NifH; pfam00142 441771002034 Nitrogenase molybdenum-iron protein, alpha and beta chains [Energy production and conversion]; Region: NifD; COG2710 441771002035 Nitrogenase component 1 type Oxidoreductase; Region: Oxidored_nitro; pfam00148 441771002036 The nitrogenase enzyme system catalyzes the ATP-dependent reduction of dinitrogen to ammonia. This group contains both alpha and beta subunits of component 1 of the three known genetically distinct types of nitrogenase systems: a molybdenum-dependent; Region: Oxidoreductase_nitrogenase; cd00316 441771002037 Cache domain; Region: Cache_1; pfam02743 441771002038 Methyl-accepting chemotaxis protein [Cell motility and secretion / Signal transduction mechanisms]; Region: Tar; COG0840 441771002039 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 441771002040 dimerization interface [polypeptide binding]; other site 441771002041 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cl19050 441771002042 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cl19050 441771002043 dimer interface [polypeptide binding]; other site 441771002044 putative CheW interface [polypeptide binding]; other site 441771002045 Domain of unknown function (DUF4317); Region: DUF4317; pfam14199 441771002046 glycine cleavage system aminomethyltransferase T; Reviewed; Region: gcvT; PRK00389 441771002047 Aminomethyltransferase folate-binding domain; Region: GCV_T; pfam01571 441771002048 Glycine cleavage T-protein C-terminal barrel domain; Region: GCV_T_C; pfam08669 441771002049 Glycine cleavage H-protein. Glycine cleavage H-proteins are part of the glycine cleavage system (GCS) found in bacteria, archea and the mitochondria of eukaryotes. GCS is a multienzyme complex consisting of 4 different components (P-, H-, T- and...; Region: GCS_H; cd06848 441771002050 lipoyl attachment site [posttranslational modification]; other site 441771002051 Glycine cleavage system P-protein, alpha- and beta-subunits. This family consists of Glycine cleavage system P-proteins EC:1.4.4.2 from bacterial, mammalian and plant sources. The P protein is part of the glycine decarboxylase multienzyme complex EC:2.1; Region: GDC-P; cd00613 441771002052 tetramer interface [polypeptide binding]; other site 441771002053 pyridoxal 5'-phosphate binding site [chemical binding]; other site 441771002054 catalytic residue [active] 441771002055 Glycine cleavage system P-protein, alpha- and beta-subunits. This family consists of Glycine cleavage system P-proteins EC:1.4.4.2 from bacterial, mammalian and plant sources. The P protein is part of the glycine decarboxylase multienzyme complex EC:2.1; Region: GDC-P; cd00613 441771002056 tetramer interface [polypeptide binding]; other site 441771002057 pyridoxal 5'-phosphate binding site [chemical binding]; other site 441771002058 catalytic residue [active] 441771002059 dihydrolipoamide dehydrogenase; Region: lipoamide_DH; TIGR01350 441771002060 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 441771002061 Pyridine nucleotide-disulphide oxidoreductase, dimerization domain; Region: Pyr_redox_dim; pfam02852 441771002062 Lipoate-protein ligase A [Coenzyme metabolism]; Region: LplA; COG0095 441771002063 lipoyltransferase and lipoate-protein ligase; Region: lipoyltrans; TIGR00545 441771002064 Bacterial lipoate protein ligase C-terminus; Region: Lip_prot_lig_C; pfam10437 441771002065 DNA-binding transcriptional regulator SoxS; Provisional; Region: PRK10219 441771002066 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 441771002067 GyrI-like small molecule binding domain; Region: GyrI-like; cl01368 441771002068 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4185 441771002069 Predicted transcriptional regulators [Transcription]; Region: SoxR; COG0789 441771002070 Helix-Turn-Helix DNA binding domain of transcription regulators from the MerR superfamily; Region: HTH_MerR-SF; cl02600 441771002071 DNA binding residues [nucleotide binding] 441771002072 Helix-Turn-Helix DNA binding domain of MerR-like transcription regulators; Region: HTH_MerR-like; cd00592 441771002073 DNA binding residues [nucleotide binding] 441771002074 Zn(II)-responsive transcriptional regulator; Region: ZntR; TIGR02043 441771002075 dimer interface [polypeptide binding]; other site 441771002076 ABC-type Mn/Zn transport systems, ATPase component [Inorganic ion transport and metabolism]; Region: ZnuC; COG1121 441771002077 ATP-binding cassette domain of the drug resistance transporter and related proteins, subfamily A; Region: ABC_DR_subfamily_A; cd03230 441771002078 Walker A/P-loop; other site 441771002079 ATP binding site [chemical binding]; other site 441771002080 Q-loop/lid; other site 441771002081 ABC transporter signature motif; other site 441771002082 Walker B; other site 441771002083 D-loop; other site 441771002084 H-loop/switch region; other site 441771002085 ABC-2 type transporter; Region: ABC2_membrane; pfam01061 441771002086 ABC-type multidrug transport system, permease component [Defense mechanisms]; Region: COG0842 441771002087 Excinuclease ATPase subunit [DNA replication, recombination, and repair]; Region: UvrA; COG0178 441771002088 ATP-binding cassette domain I of the excision repair protein UvrA; Region: ABC_UvrA_I; cd03270 441771002089 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 441771002090 Walker A/P-loop; other site 441771002091 ATP binding site [chemical binding]; other site 441771002092 Q-loop/lid; other site 441771002093 Zinc finger domain of DnaJ and HSP40; Region: DnaJ_zf; cl19048 441771002094 ABC transporter signature motif; other site 441771002095 Walker B; other site 441771002096 D-loop; other site 441771002097 H-loop/switch region; other site 441771002098 UvrD/REP helicase N-terminal domain; Region: UvrD-helicase; pfam00580 441771002099 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 441771002100 Walker A motif; other site 441771002101 ATP binding site [chemical binding]; other site 441771002102 UvrD-like helicase C-terminal domain; Region: UvrD_C_2; pfam13538 441771002103 Phage protein Gp37/Gp68; Region: Gp37_Gp68; cl15384 441771002104 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 441771002105 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 441771002106 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3708 441771002107 Carboxylate/Amino Acid/Amine Transporter; Region: 2A78; TIGR00950 441771002108 EamA-like transporter family; Region: EamA; pfam00892 441771002109 EamA-like transporter family; Region: EamA; pfam00892 441771002110 TfoX C-terminal domain; Region: TfoX_C; pfam04994 441771002111 Acetyltransferase (GNAT) domain; Region: Acetyltransf_3; pfam13302 441771002112 Acetyltransferase (GNAT) family; Region: Acetyltransf_1; pfam00583 441771002113 3-oxoacyl-[acyl-carrier-protein]; Region: FabH; COG0332 441771002114 Condensing enzymes; Family of enzymes that catalyze a (decarboxylating or non-decarboxylating) Claisen-like condensation reaction. Members are share strong structural similarity, and are involved in the synthesis and degradation of fatty acids, and the...; Region: cond_enzymes; cl09938 441771002115 active site 441771002116 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cl19050 441771002117 Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer); Region: MA; smart00283 441771002118 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cl19050 441771002119 dimer interface [polypeptide binding]; other site 441771002120 putative CheW interface [polypeptide binding]; other site 441771002121 Mor transcription activator family; Region: Mor; cl02360 441771002122 ATPase components of ABC transporters with duplicated ATPase domains [General function prediction only]; Region: Uup; COG0488 441771002123 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 441771002124 ABC transporter; Region: ABC_tran_2; pfam12848 441771002125 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 441771002126 Putative intracellular protease/amidase [General function prediction only]; Region: ThiJ; COG0693 441771002127 Type 1 glutamine amidotransferase (GATase1)-like domain; Region: GAT_1; cl00020 441771002128 conserved cys residue [active] 441771002129 cysteine synthase; Region: PLN02565 441771002130 CBS_like: This subgroup includes Cystathionine beta-synthase (CBS) and Cysteine synthase. CBS is a unique heme-containing enzyme that catalyzes a pyridoxal 5'-phosphate (PLP)-dependent condensation of serine and homocysteine to give cystathionine; Region: CBS_like; cd01561 441771002131 dimer interface [polypeptide binding]; other site 441771002132 pyridoxal 5'-phosphate binding site [chemical binding]; other site 441771002133 catalytic residue [active] 441771002134 S-ribosylhomocysteinase; Provisional; Region: PRK02260 441771002135 CGS_like: Cystathionine gamma-synthase is a PLP dependent enzyme and catalyzes the committed step of methionine biosynthesis. This pathway is unique to microorganisms and plants, rendering the enzyme an attractive target for the development of...; Region: CGS_like; cd00614 441771002136 homodimer interface [polypeptide binding]; other site 441771002137 substrate-cofactor binding pocket; other site 441771002138 pyridoxal 5'-phosphate binding site [chemical binding]; other site 441771002139 catalytic residue [active] 441771002140 Methyltransferase domain; Region: Methyltransf_31; pfam13847 441771002141 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 441771002142 S-adenosylmethionine binding site [chemical binding]; other site 441771002143 Glyco_18 domain; Region: Glyco_18; smart00636 441771002144 The GH18 (glycosyl hydrolases, family 18) type II chitinases hydrolyze chitin, an abundant polymer of N-acetylglucosamine and have been identified in bacteria, fungi, insects, plants, viruses, and protozoan parasites. The structure of this domain is an...; Region: GH18_chitinase; cd06548 441771002145 active site 441771002146 Chitinase C; Region: ChiC; pfam06483 441771002147 Heavy-metal-associated domain (HMA) is a conserved domain of approximately 30 amino acid residues found in a number of proteins that transport or detoxify heavy metals, for example, the CPx-type heavy metal ATPases and copper chaperones. HMA domain...; Region: HMA; cd00371 441771002148 metal-binding site [ion binding] 441771002149 Domain of unknown function (DUF4071); Region: DUF4071; pfam13281 441771002150 Cupin superfamily (DUF985); Region: Cupin_5; pfam06172 441771002151 Domain of unknown function (DUF955); Region: DUF955; pfam06114 441771002152 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 441771002153 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 441771002154 non-specific DNA binding site [nucleotide binding]; other site 441771002155 salt bridge; other site 441771002156 sequence-specific DNA binding site [nucleotide binding]; other site 441771002157 Replication initiation and membrane attachment; Region: DnaB_2; pfam07261 441771002158 RNA polymerase sigma factor, sigma-70 family; Region: sigma70-ECF; TIGR02937 441771002159 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 441771002160 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cl17257 441771002161 DNA binding residues [nucleotide binding] 441771002162 four helix bundle protein; Region: TIGR02436 441771002163 YvrJ protein family; Region: YvrJ; pfam12841 441771002164 metallophosphatase superfamily, metallophosphatase domain; Region: MPP_superfamily; cl13995 441771002165 active site 441771002166 metal binding site [ion binding]; metal-binding site 441771002167 metallophosphatase superfamily, metallophosphatase domain; Region: MPP_superfamily; cl13995 441771002168 Protein of unknown function (DUF1659); Region: DUF1659; pfam07872 441771002169 Protein of unknown function (DUF2922); Region: DUF2922; pfam11148 441771002170 Peptidoglycan recognition proteins (PGRPs) are pattern recognition receptors that bind, and in certain cases, hydrolyze peptidoglycans (PGNs) of bacterial cell walls. PGRPs have been divided into three classes: short PGRPs (PGRP-S), that are small (20...; Region: PGRP; cd06583 441771002171 amidase catalytic site [active] 441771002172 Zn binding residues [ion binding]; other site 441771002173 substrate binding site [chemical binding]; other site 441771002174 Putative peptidoglycan binding domain; Region: PG_binding_1; pfam01471 441771002175 Protein of unknown function (DUF2762); Region: DUF2762; pfam10960 441771002176 Bacterial SH3 domain homologues; Region: SH3b; smart00287 441771002177 Transposase; Region: Transposase_7; pfam01526 441771002178 Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118 441771002179 Domain of Unknown Function (DUF1259); Region: DUF1529; pfam07485 441771002180 Domain of Unknown Function (DUF1259); Region: DUF1529; pfam07485 441771002181 Protein-tyrosine-phosphatase [Signal transduction mechanisms]; Region: Wzb; COG0394 441771002182 active site 441771002183 Putative redox-active protein (C_GCAxxG_C_C); Region: C_GCAxxG_C_C; pfam09719 441771002184 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 441771002185 dimerization interface [polypeptide binding]; other site 441771002186 putative DNA binding site [nucleotide binding]; other site 441771002187 putative Zn2+ binding site [ion binding]; other site 441771002188 Arsenical resistance operon trans-acting repressor ArsD; Region: ArsD; pfam06953 441771002189 arsenical pump-driving ATPase; Region: arsen_driv_ArsA; TIGR04291 441771002190 ArsA ATPase functionas as an efflux pump located on the inner membrane of the cell. This ATP-driven oxyanion pump catalyzes the extrusion of arsenite, antimonite and arsenate. Maintenance of a low intracellular concentration of oxyanion produces...; Region: ArsA; cd02035 441771002191 P loop; other site 441771002192 Nucleotide binding site [chemical binding]; other site 441771002193 DTAP/Switch II; other site 441771002194 Switch I; other site 441771002195 ArsA ATPase functionas as an efflux pump located on the inner membrane of the cell. This ATP-driven oxyanion pump catalyzes the extrusion of arsenite, antimonite and arsenate. Maintenance of a low intracellular concentration of oxyanion produces...; Region: ArsA; cd02035 441771002196 P loop; other site 441771002197 Nucleotide binding site [chemical binding]; other site 441771002198 DTAP/Switch II; other site 441771002199 Switch I; other site 441771002200 Arsenite efflux pump ACR3 and related permeases [Inorganic ion transport and metabolism]; Region: ACR3; COG0798 441771002201 Histidine phosphatase domain found in a functionally diverse set of proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP; cd07040 441771002202 catalytic core [active] 441771002203 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 441771002204 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 441771002205 Cysteine-rich KTR; Region: Cys_rich_KTR; pfam14205 441771002206 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 441771002207 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 441771002208 non-specific DNA binding site [nucleotide binding]; other site 441771002209 salt bridge; other site 441771002210 sequence-specific DNA binding site [nucleotide binding]; other site 441771002211 ABC-type multidrug transport system, ATPase component [Defense mechanisms]; Region: CcmA; COG1131 441771002212 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 441771002213 Walker A/P-loop; other site 441771002214 ATP binding site [chemical binding]; other site 441771002215 Q-loop/lid; other site 441771002216 ABC transporter signature motif; other site 441771002217 Walker B; other site 441771002218 D-loop; other site 441771002219 H-loop/switch region; other site 441771002220 Apolipophorin-III and similar insect proteins; Region: ApoLp-III_like; cl19113 441771002221 Acyltransferase family; Region: Acyl_transf_3; cl19154 441771002222 Nucleoside 2-deoxyribosyltransferase; Region: Nuc_deoxyrib_tr; cl17818 441771002223 Thymidylate synthase and pyrimidine hydroxymethylase: Thymidylate synthase (TS) and deoxycytidylate hydroxymethylase (dCMP-HMase) are homologs that catalyze analogous alkylation of C5 of pyrimidine nucleotides. Both enzymes are involved in the...; Region: TS_Pyrimidine_HMase; cd00351 441771002224 dimerization interface [polypeptide binding]; other site 441771002225 active site 441771002226 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 441771002227 S-adenosylmethionine binding site [chemical binding]; other site 441771002228 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; pfam01547 441771002229 4-amino-5-hydroxymethyl-2-methyl-pyrimidine phosphate kinase (HMPP-kinase) catalyzes two consecutive phosphorylation steps in the thiamine phosphate biosynthesis pathway, leading to the synthesis of vitamin B1. The first step is the phosphorylation of...; Region: HMPP_kinase; cd01169 441771002230 dimer interface [polypeptide binding]; other site 441771002231 substrate binding site [chemical binding]; other site 441771002232 ATP binding site [chemical binding]; other site 441771002233 Putative small multi-drug export protein; Region: Sm_multidrug_ex; pfam06695 441771002234 ABC-type multidrug transport system, ATPase component [Defense mechanisms]; Region: CcmA; COG1131 441771002235 ATP-binding cassette domain of the drug resistance transporter and related proteins, subfamily A; Region: ABC_DR_subfamily_A; cd03230 441771002236 Walker A/P-loop; other site 441771002237 ATP binding site [chemical binding]; other site 441771002238 Q-loop/lid; other site 441771002239 ABC transporter signature motif; other site 441771002240 Walker B; other site 441771002241 D-loop; other site 441771002242 H-loop/switch region; other site 441771002243 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 441771002244 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 441771002245 active site 441771002246 phosphorylation site [posttranslational modification] 441771002247 intermolecular recognition site; other site 441771002248 dimerization interface [polypeptide binding]; other site 441771002249 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 441771002250 DNA binding site [nucleotide binding] 441771002251 ABC-type multidrug transport system, ATPase component [Defense mechanisms]; Region: CcmA; COG1131 441771002252 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 441771002253 Walker A/P-loop; other site 441771002254 ATP binding site [chemical binding]; other site 441771002255 Q-loop/lid; other site 441771002256 ABC transporter signature motif; other site 441771002257 Walker B; other site 441771002258 D-loop; other site 441771002259 H-loop/switch region; other site 441771002260 ABC-2 family transporter protein; Region: ABC2_membrane_4; pfam12730 441771002261 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 441771002262 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 441771002263 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 441771002264 Bacterial transcription activator, effector binding domain; Region: AraC_E_bind; smart00871 441771002265 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 441771002266 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 441771002267 dimer interface [polypeptide binding]; other site 441771002268 phosphorylation site [posttranslational modification] 441771002269 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 441771002270 ATP binding site [chemical binding]; other site 441771002271 Mg2+ binding site [ion binding]; other site 441771002272 G-X-G motif; other site 441771002273 Protein of unknown function (DUF4003); Region: DUF4003; pfam13170 441771002274 ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136 441771002275 ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255 441771002276 Walker A/P-loop; other site 441771002277 ATP binding site [chemical binding]; other site 441771002278 Q-loop/lid; other site 441771002279 ABC transporter signature motif; other site 441771002280 Walker B; other site 441771002281 D-loop; other site 441771002282 H-loop/switch region; other site 441771002283 MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704 441771002284 ABC-type antimicrobial peptide transport system, permease component [Defense mechanisms]; Region: SalY; COG0577 441771002285 FtsX-like permease family; Region: FtsX; pfam02687 441771002286 ABC-type transport system, involved in lipoprotein release, permease component [Cell envelope biogenesis, outer membrane]; Region: LolE; COG4591 441771002287 MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704 441771002288 FtsX-like permease family; Region: FtsX; pfam02687 441771002289 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 441771002290 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 441771002291 active site 441771002292 phosphorylation site [posttranslational modification] 441771002293 intermolecular recognition site; other site 441771002294 dimerization interface [polypeptide binding]; other site 441771002295 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 441771002296 DNA binding site [nucleotide binding] 441771002297 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 441771002298 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 441771002299 dimer interface [polypeptide binding]; other site 441771002300 phosphorylation site [posttranslational modification] 441771002301 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 441771002302 ATP binding site [chemical binding]; other site 441771002303 Mg2+ binding site [ion binding]; other site 441771002304 G-X-G motif; other site 441771002305 Uncharacterized ACR, YkgG family COG1556; Region: DUF162; pfam02589 441771002306 small acid-soluble spore protein, H-type; Region: SASP_H; TIGR02861 441771002307 Protein of unknown function (DUF3816); Region: DUF3816; cl17272 441771002308 dihydrodipicolinate reductase; Provisional; Region: PRK00048 441771002309 Dihydrodipicolinate reductase, N-terminus; Region: DapB_N; pfam01113 441771002310 Dihydrodipicolinate reductase, C-terminus; Region: DapB_C; pfam05173 441771002311 Rhodanese-related sulfurtransferase [Inorganic ion transport and metabolism]; Region: SseA; COG2897 441771002312 Thiosulfate sulfurtransferase (TST), N-terminal, inactive domain. TST contains 2 copies of the Rhodanese Homology Domain; this is the 1st repeat, which does not contain the catalytically active Cys residue. The role of the 1st repeat is uncertain, but it...; Region: TST_Repeat_1; cd01448 441771002313 active site residue [active] 441771002314 Thiosulfate sulfurtransferase (TST), C-terminal, catalytic domain. TST contains 2 copies of the Rhodanese Homology Domain; this is the second repeat. Only the second repeat contains the catalytically active Cys residue; Region: TST_Repeat_2; cd01449 441771002315 active site residue [active] 441771002316 Flagellin and related hook-associated proteins [Cell motility and secretion]; Region: FlgL; COG1344 441771002317 Bacterial flagellin N-terminal helical region; Region: Flagellin_N; pfam00669 441771002318 Helix-turn-helix domain; Region: HTH_28; pfam13518 441771002319 Clostridium enterotoxin; Region: Clenterotox; pfam03505 441771002320 Clostridium botulinum HA-17 protein; Region: Botulinum_HA-17; pfam05588 441771002321 Ricin-type beta-trefoil; Region: RICIN; smart00458 441771002322 Ricin-type beta-trefoil; Region: RICIN; smart00458 441771002323 Ricin-type beta-trefoil; Carbohydrate-binding domain formed from presumed gene triplication. The domain is found in a variety of molecules serving diverse functions such as enzymatic activity, inhibitory toxicity and signal transduction. Highly specific...; Region: RICIN; cd00161 441771002324 putative sugar binding sites [chemical binding]; other site 441771002325 Q-X-W motif; other site 441771002326 clostridium toxin-associated regulator BotR; Region: P21_Cbot; TIGR03209 441771002327 Sigma-70, region 4; Region: Sigma70_r4_2; pfam08281 441771002328 DNA binding residues [nucleotide binding] 441771002329 Clostridial neurotoxin zinc protease; Region: Peptidase_M27; pfam01742 441771002330 Clostridium neurotoxin, Translocation domain; Region: Toxin_trans; pfam07952 441771002331 Clostridium neurotoxin, N-terminal receptor binding; Region: Toxin_R_bind_N; pfam07953 441771002332 Nontoxic nonhaemagglutinin C-terminal; Region: NTNH_C; pfam08470 441771002333 Clostridial neurotoxin zinc protease; Region: Peptidase_M27; pfam01742 441771002334 Clostridium neurotoxin, Translocation domain; Region: Toxin_trans; pfam07952 441771002335 Clostridium neurotoxin, N-terminal receptor binding; Region: Toxin_R_bind_N; pfam07953 441771002336 Clostridium neurotoxin, C-terminal receptor binding; Region: Toxin_R_bind_C; pfam07951 441771002337 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: Tra5; COG2801 441771002338 HTH-like domain; Region: HTH_21; pfam13276 441771002339 Integrase core domain; Region: rve; pfam00665 441771002340 Integrase core domain; Region: rve_3; pfam13683 441771002341 zinc-ribbon domain; Region: zinc_ribbon_2; pfam13240 441771002342 Imidazolonepropionase and related amidohydrolases [Secondary metabolites biosynthesis, transport, and catabolism]; Region: HutI; COG1228 441771002343 Metallo-dependent hydrolases, subgroup C is part of the superfamily of metallo-dependent hydrolases, a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the...; Region: Met_dep_hydrolase_C; cd01309 441771002344 active site 441771002345 Branched-chain amino acid transport protein; Region: Branch_AA_trans; cl00547 441771002346 Branched-chain amino acid transport protein; Region: Branch_AA_trans; cl00547 441771002347 Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer); Region: MA; smart00283 441771002348 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 441771002349 dimer interface [polypeptide binding]; other site 441771002350 putative CheW interface [polypeptide binding]; other site 441771002351 ABC-type dipeptide transport system, periplasmic component [Amino acid transport and metabolism]; Region: DdpA; COG0747 441771002352 The substrate-binding domain of an ABC-type nickel/oligopeptide-like import system contains the type 2 periplasmic binding fold; Region: PBP2_NikA_DppA_OppA_like; cd00995 441771002353 FeoA domain; Region: FeoA; pfam04023 441771002354 Circularly permuted YlqF-related GTPases; Region: YlqF_related_GTPase; cl17249 441771002355 GTP/Mg2+ binding site [chemical binding]; other site 441771002356 G5 box; other site 441771002357 Fe2+ transport system protein B [Inorganic ion transport and metabolism]; Region: FeoB; COG0370 441771002358 Ferrous iron transport protein B (FeoB) family; Region: FeoB; cd01879 441771002359 G1 box; other site 441771002360 G1 box; other site 441771002361 GTP/Mg2+ binding site [chemical binding]; other site 441771002362 Switch I region; other site 441771002363 G2 box; other site 441771002364 G3 box; other site 441771002365 Switch II region; other site 441771002366 G4 box; other site 441771002367 G5 box; other site 441771002368 Fe2+ transport system protein B [Inorganic ion transport and metabolism]; Region: FeoB; COG0370 441771002369 Nucleoside recognition; Region: Gate; pfam07670 441771002370 Ferrous iron transport protein B C terminus; Region: FeoB_C; pfam07664 441771002371 Nucleoside recognition; Region: Gate; pfam07670 441771002372 Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067 441771002373 catalytic core [active] 441771002374 Uncharacterized vancomycin resistance protein [Defense mechanisms]; Region: COG2720 441771002375 Putative peptidoglycan binding domain; Region: PG_binding_4; pfam12229 441771002376 VanW like protein; Region: VanW; pfam04294 441771002377 G5 domain; Region: G5; pfam07501 441771002378 cobalamin synthase; Reviewed; Region: cobS; PRK00235 441771002379 AIR synthase related protein, N-terminal domain; Region: AIRS; pfam00586 441771002380 Domain of unknown function (DUF4491); Region: DUF4491; pfam14898 441771002381 Coat F domain; Region: Coat_F; pfam07875 441771002382 Putative NodB-like catalytic domain of uncharacterized proteins found in bacteria; Region: CE4_COG5298; cd10923 441771002383 NodB motif; other site 441771002384 putative active site [active] 441771002385 putative catalytic site [active] 441771002386 putative Zn binding site [ion binding]; other site 441771002387 6-pyruvoyl tetrahydropterin synthase; Region: PTPS; pfam01242 441771002388 active site 441771002389 DHPS subgroup of Pterin binding enzymes. DHPS (dihydropteroate synthase), a functional homodimer, catalyzes the condensation of p-aminobenzoic acid (pABA) in the de novo biosynthesis of folate, which is an essential cofactor in both nucleic acid and...; Region: DHPS; cd00739 441771002390 Dihydropteroate synthase and related enzymes [Coenzyme metabolism]; Region: FolP; COG0294 441771002391 substrate binding pocket [chemical binding]; other site 441771002392 dimer interface [polypeptide binding]; other site 441771002393 inhibitor binding site; inhibition site 441771002394 Uncharacterized protein, DegV family COG1307; Region: DegV; cl19360 441771002395 7,8-dihydro-6-hydroxymethylpterin-pyrophosphokinase (HPPK). Folate derivatives are essential cofactors in the biosynthesis of purines, pyrimidines, and amino acids as well as formyl-tRNA. Mammalian cells are able to utilize pre-formed folates after...; Region: HPPK; cd00483 441771002396 catalytic center binding site [active] 441771002397 ATP binding site [chemical binding]; other site 441771002398 Molecular chaperone (small heat shock protein) [Posttranslational modification, protein turnover, chaperones]; Region: IbpA; COG0071 441771002399 Group of bacterial proteins containing an alpha crystallin domain (ACD) similar to Lactobacillus plantarum (Lp) small heat shock proteins (sHsp) HSP 18.5, HSP 18.55 and HSP 19.3. sHsps are molecular chaperones that suppress protein aggregation and...; Region: ACD_LpsHSP_like; cd06471 441771002400 putative dimer interface [polypeptide binding]; other site 441771002401 Predicted transcriptional regulators [Transcription]; Region: SoxR; COG0789 441771002402 Helix-Turn-Helix DNA binding domain of the transcription regulators TipAL, Mta, and SkgA; Region: HTH_TipAL-Mta; cd01106 441771002403 DNA binding residues [nucleotide binding] 441771002404 dimer interface [polypeptide binding]; other site 441771002405 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 441771002406 S-adenosylmethionine binding site [chemical binding]; other site 441771002407 lipopolysaccharide biosynthesis protein RfbH; Provisional; Region: PRK15407 441771002408 3-amino-5-hydroxybenzoic acid synthase family (AHBA_syn). AHBA_syn family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The members of this CD are involved in various biosynthetic pathways for secondary...; Region: AHBA_syn; cd00616 441771002409 inhibitor-cofactor binding pocket; inhibition site 441771002410 pyridoxal 5'-phosphate binding site [chemical binding]; other site 441771002411 catalytic residue [active] 441771002412 3-amino-5-hydroxybenzoic acid synthase family (AHBA_syn). AHBA_syn family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The members of this CD are involved in various biosynthetic pathways for secondary...; Region: AHBA_syn; cd00616 441771002413 inhibitor-cofactor binding pocket; inhibition site 441771002414 pyridoxal 5'-phosphate binding site [chemical binding]; other site 441771002415 catalytic residue [active] 441771002416 Site-specific DNA methylase [DNA replication, recombination, and repair]; Region: Dcm; COG0270 441771002417 cofactor binding site; other site 441771002418 DNA binding site [nucleotide binding] 441771002419 substrate interaction site [chemical binding]; other site 441771002420 RNA polymerase sigma-70 factor, TIGR02954 family; Region: Sig70_famx3 441771002421 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 441771002422 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 441771002423 DNA binding residues [nucleotide binding] 441771002424 Domain of unknown function (DUF4179); Region: DUF4179; pfam13786 441771002425 Conserved protein/domain typically associated with flavoprotein oxygenases, DIM6/NTAB family [General function prediction only]; Region: COG1853 441771002426 Alpha/beta hydrolase of unknown function (DUF1057); Region: DUF1057; pfam06342 441771002427 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 441771002428 Cadmium resistance transporter; Region: Cad; cl19409 441771002429 Protein of unknown function (DUF523); Region: DUF523; pfam04463 441771002430 Acyltransferase family; Region: Acyl_transf_3; cl19154 441771002431 ABC-type multidrug transport system, ATPase component [Defense mechanisms]; Region: CcmA; COG1131 441771002432 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 441771002433 Walker A/P-loop; other site 441771002434 ATP binding site [chemical binding]; other site 441771002435 Q-loop/lid; other site 441771002436 ABC transporter signature motif; other site 441771002437 Walker B; other site 441771002438 D-loop; other site 441771002439 H-loop/switch region; other site 441771002440 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 441771002441 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 441771002442 non-specific DNA binding site [nucleotide binding]; other site 441771002443 salt bridge; other site 441771002444 sequence-specific DNA binding site [nucleotide binding]; other site 441771002445 TIGR04076 family protein; Region: TIGR04076 441771002446 Predicted epimerase, PhzC/PhzF homolog [General function prediction only]; Region: COG0384 441771002447 Diaminopimelate epimerase; Region: DAP_epimerase; cl19724 441771002448 Transcriptional regulators [Transcription]; Region: Lrp; COG1522 441771002449 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cl17220 441771002450 Putative lysophospholipase; Region: Hydrolase_4; cl19140 441771002451 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 441771002452 Putative lysophospholipase; Region: Hydrolase_4; cl19140 441771002453 Acetyltransferases, including N-acetylases of ribosomal proteins [Translation, ribosomal structure and biogenesis]; Region: RimL; COG1670 441771002454 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl17182 441771002455 Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805 441771002456 Pentapeptide repeats (9 copies); Region: Pentapeptide_4; pfam13599 441771002457 Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805 441771002458 NADPH-dependent FMN reductase; Region: FMN_red; cl00438 441771002459 Multimeric flavodoxin WrbA [General function prediction only]; Region: WrbA; COG0655 441771002460 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 441771002461 dimerization interface [polypeptide binding]; other site 441771002462 putative DNA binding site [nucleotide binding]; other site 441771002463 putative Zn2+ binding site [ion binding]; other site 441771002464 Predicted transcriptional regulators [Transcription]; Region: SoxR; COG0789 441771002465 Helix-Turn-Helix DNA binding domain of transcription regulators from the MerR superfamily; Region: HTH_MerR-SF; cl02600 441771002466 DNA binding residues [nucleotide binding] 441771002467 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 441771002468 Acetyltransferases [General function prediction only]; Region: RimI; COG0456 441771002469 Coenzyme A binding pocket [chemical binding]; other site 441771002470 GrpB protein; Region: GrpB; pfam04229 441771002471 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 441771002472 Coenzyme A binding pocket [chemical binding]; other site 441771002473 Pirin-related protein [General function prediction only]; Region: COG1741 441771002474 Pirin; Region: Pirin; pfam02678 441771002475 Predicted transcriptional regulators [Transcription]; Region: COG1733 441771002476 dimerization interface [polypeptide binding]; other site 441771002477 putative DNA binding site [nucleotide binding]; other site 441771002478 Transcriptional regulators [Transcription]; Region: Lrp; COG1522 441771002479 putative Zn2+ binding site [ion binding]; other site 441771002480 Nitroreductase-like family 1. A subfamily of the nitroreductase family containing uncharacterized proteins that are similar to nitroreductase. Nitroreductase catalyzes the reduction of nitroaromatic compounds such as nitrotoluenes, nitrofurans and...; Region: Nitroreductase_1; cd02137 441771002481 dimer interface [polypeptide binding]; other site 441771002482 FMN binding site [chemical binding]; other site 441771002483 Putative lysophospholipase; Region: Hydrolase_4; cl19140 441771002484 bicupin, oxalate decarboxylase family; Region: bicupin_oxalic; TIGR03404 441771002485 Cupin; Region: Cupin_1; smart00835 441771002486 Thermophilic glucose-6-phosphate isomerase and related metalloenzymes [Carbohydrate transport and metabolism / General function prediction only]; Region: COG2140 441771002487 DNA recombination-mediator protein A; Region: DNA_processg_A; cl00695 441771002488 Protein of unknown function, DUF606; Region: DUF606; pfam04657 441771002489 Transcriptional regulator [Transcription]; Region: LysR; COG0583 441771002490 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 441771002491 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cd05466 441771002492 dimerization interface [polypeptide binding]; other site 441771002493 Acetyltransferase (GNAT) domain; Region: Acetyltransf_10; pfam13673 441771002494 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 441771002495 Coenzyme A binding pocket [chemical binding]; other site 441771002496 Protein of unknown function, DUF606; Region: DUF606; cl01273 441771002497 cAMP-binding proteins - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases [Signal transduction mechanisms]; Region: Crp; COG0664 441771002498 Crp-like helix-turn-helix domain; Region: HTH_Crp_2; pfam13545 441771002499 putative switch regulator; other site 441771002500 DNA binding site [nucleotide binding] 441771002501 sequence specific DNA binding site [nucleotide binding]; other site 441771002502 putative cAMP binding site [chemical binding]; other site 441771002503 Predicted transcriptional regulator [Transcription]; Region: COG2378 441771002504 HTH domain; Region: HTH_11; pfam08279 441771002505 WYL domain; Region: WYL; pfam13280 441771002506 Protein of unknown function (DUF3815); Region: DUF3815; pfam12821 441771002507 Uncharacterized conserved protein [Function unknown]; Region: COG2966 441771002508 Protein of unknown function (DUF1212); Region: DUF1212; pfam06738 441771002509 Polypeptide or peptide deformylase; a family of metalloenzymes that catalyzes the removal of the N-terminal formyl group in a growing polypeptide chain following translation initiation during protein synthesis in prokaryotes. These enzymes utilize Fe(II)...; Region: Pep_deformylase; cd00487 441771002510 active site 441771002511 catalytic residues [active] 441771002512 metal binding site [ion binding]; metal-binding site 441771002513 Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain (MocR family) and their eukaryotic orthologs [Transcription / Amino acid transport and metabolism]; Region: ARO8; COG1167 441771002514 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 441771002515 DNA-binding site [nucleotide binding]; DNA binding site 441771002516 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 441771002517 pyridoxal 5'-phosphate binding site [chemical binding]; other site 441771002518 homodimer interface [polypeptide binding]; other site 441771002519 catalytic residue [active] 441771002520 Nitroreductase-like family 3. A subfamily of the nitroreductase family containing uncharacterized proteins that are similar to nitroreductase. Nitroreductase catalyzes the reduction of nitroaromatic compounds such as nitrotoluenes, nitrofurans and...; Region: Nitroreductase_3; cd02139 441771002521 putative FMN binding site [chemical binding]; other site 441771002522 Uncharacterized Fe-S protein [Energy production and conversion]; Region: COG1600 441771002523 transcriptional antiterminator BglG; Provisional; Region: PRK09772 441771002524 CAT RNA binding domain; Region: CAT_RBD; smart01061 441771002525 PRD domain; Region: PRD; pfam00874 441771002526 PRD domain; Region: PRD; pfam00874 441771002527 PTS system, beta-glucoside-specific IIABC component; Region: PTS-II-ABC-beta; TIGR01995 441771002528 PTS_IIB, PTS system, glucose/sucrose specific IIB subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIB_glc; cd00212 441771002529 active site turn [active] 441771002530 phosphorylation site [posttranslational modification] 441771002531 Phosphotransferase system IIC components, glucose/maltose/N-acetylglucosamine-specific [Carbohydrate transport and metabolism]; Region: PtsG; COG1263 441771002532 Phosphotransferase system IIA components [Carbohydrate transport and metabolism]; Region: NagE; COG2190 441771002533 HPr interaction site; other site 441771002534 glycerol kinase (GK) interaction site [polypeptide binding]; other site 441771002535 active site 441771002536 phosphorylation site [posttranslational modification] 441771002537 Glycosyl hydrolase family 1; Region: Glyco_hydro_1; pfam00232 441771002538 Beta-glucosidase/6-phospho-beta-glucosidase/beta- galactosidase [Carbohydrate transport and metabolism]; Region: BglB; cl01046 441771002539 Phospho-N-acetylmuramoyl-pentapeptide-transferase (mraY) is an enzyme responsible for the formation of the first lipid intermediate in the synthesis of bacterial cell wall peptidoglycan. It catalyzes the formation of...; Region: GT_MraY; cd06852 441771002540 Mg++ binding site [ion binding]; other site 441771002541 putative catalytic motif [active] 441771002542 putative substrate binding site [chemical binding]; other site 441771002543 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 441771002544 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 441771002545 non-specific DNA binding site [nucleotide binding]; other site 441771002546 sequence-specific DNA binding site [nucleotide binding]; other site 441771002547 salt bridge; other site 441771002548 Left-handed parallel beta-Helix (LbetaH or LbH) domain: The alignment contains 5 turns, each containing three imperfect tandem repeats of a hexapeptide repeat motif (X-[STAV]-X-[LIV]-[GAED]-X). Proteins containing hexapeptide repeats are often enzymes...; Region: LbetaH; cl00160 441771002549 Uncharacterized ACR, YkgG family COG1556; Region: DUF162; pfam02589 441771002550 The first Cupredoxin domain of Bilirubin oxidase (BOD), the bacterial endospore coat component CotA, and similar proteins; Region: CuRO_1_BOD_CotA_like; cd13844 441771002551 dimer interface [polypeptide binding]; other site 441771002552 hexamer interface [polypeptide binding]; other site 441771002553 Domain 2 interface [polypeptide binding]; other site 441771002554 Putative multicopper oxidases [Secondary metabolites biosynthesis, transport, and catabolism]; Region: SufI; COG2132 441771002555 Domain 3 interface [polypeptide binding]; other site 441771002556 trinuclear Cu binding site [ion binding]; other site 441771002557 The second Cupredoxin domain of bacterial laccases including CotA, a bacterial endospore coat component; Region: CuRO_2_CotA_like; cd13868 441771002558 Domain 1 interface [polypeptide binding]; other site 441771002559 Domain 3 interface [polypeptide binding]; other site 441771002560 The third Cupredoxin domain of bacterial laccases including CotA, a bacterial endospore coat component; Region: CuRO_3_CotA_like; cd13891 441771002561 Domain 1 interface [polypeptide binding]; other site 441771002562 Type 1 (T1) Cu binding site [ion binding]; other site 441771002563 Domain 2 interface [polypeptide binding]; other site 441771002564 trinuclear Cu binding site [ion binding]; other site 441771002565 Site-specific DNA methylase [DNA replication, recombination, and repair]; Region: Dcm; COG0270 441771002566 cofactor binding site; other site 441771002567 DNA binding site [nucleotide binding] 441771002568 substrate interaction site [chemical binding]; other site 441771002569 Peptidylarginine deiminase and related enzymes [Amino acid transport and metabolism]; Region: COG2957; cl01113 441771002570 Helix-Turn-Helix DNA binding domain of transcription regulators from the MerR superfamily; Region: HTH_MerR-SF; cl02600 441771002571 GyrI-like small molecule binding domain; Region: GyrI-like; cl01368 441771002572 Predicted membrane protein [Function unknown]; Region: COG2510 441771002573 Carboxylate/Amino Acid/Amine Transporter; Region: 2A78; TIGR00950 441771002574 Predicted membrane protein [Function unknown]; Region: COG2510 441771002575 GrpB protein; Region: GrpB; pfam04229 441771002576 Uncharacterized protein conserved in bacteria [Function unknown]; Region: ErfK; COG1376 441771002577 L,D-transpeptidase catalytic domain; Region: YkuD; pfam03734 441771002578 YmaF family; Region: YmaF; pfam12788 441771002579 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl17182 441771002580 NADH-ubiquinone/plastoquinone oxidoreductase chain 6; Region: Oxidored_q3; pfam00499 441771002581 ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136 441771002582 ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255 441771002583 Walker A/P-loop; other site 441771002584 ATP binding site [chemical binding]; other site 441771002585 Q-loop/lid; other site 441771002586 ABC transporter signature motif; other site 441771002587 Walker B; other site 441771002588 D-loop; other site 441771002589 H-loop/switch region; other site 441771002590 MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704 441771002591 ABC-type antimicrobial peptide transport system, permease component [Defense mechanisms]; Region: SalY; COG0577 441771002592 FtsX-like permease family; Region: FtsX; pfam02687 441771002593 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 441771002594 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 441771002595 active site 441771002596 phosphorylation site [posttranslational modification] 441771002597 intermolecular recognition site; other site 441771002598 dimerization interface [polypeptide binding]; other site 441771002599 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 441771002600 DNA binding site [nucleotide binding] 441771002601 BioY family; Region: BioY; pfam02632 441771002602 FOG: TPR repeat, SEL1 subfamily [General function prediction only]; Region: COG0790 441771002603 Sel1 repeat; Region: Sel1; pfam08238 441771002604 Sel1-like repeats; Region: SEL1; smart00671 441771002605 Sel1-like repeats; Region: SEL1; smart00671 441771002606 Sel1-like repeats; Region: SEL1; smart00671 441771002607 Acetyltransferase (GNAT) domain; Region: Acetyltransf_3; pfam13302 441771002608 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 441771002609 Coenzyme A binding pocket [chemical binding]; other site 441771002610 Peptidase S24 LexA-like proteins are involved in the SOS response leading to the repair of single-stranded DNA within the bacterial cell. This family includes: the lambda repressor CI/C2 family and related bacterial prophage repressor proteins; LexA (EC...; Region: S24_LexA-like; cd06529 441771002611 Catalytic site [active] 441771002612 Adenosylcobinamide kinase / adenosylcobinamide phosphate guanyltransferase (CobU). CobU is bifunctional cobalbumin biosynthesis enzymes which display adenosylcobinamide kinase and adenosylcobinamide phosphate guanyltransferase activity. This enzyme is a...; Region: CobU; cd00544 441771002613 homotrimer interface [polypeptide binding]; other site 441771002614 Walker A motif; other site 441771002615 GTP binding site [chemical binding]; other site 441771002616 Walker B motif; other site 441771002617 Predicted transcriptional regulators [Transcription]; Region: SoxR; COG0789 441771002618 Helix-Turn-Helix DNA binding domain of the transcription regulators TipAL, Mta, and SkgA; Region: HTH_TipAL-Mta; cd01106 441771002619 DNA binding residues [nucleotide binding] 441771002620 dimer interface [polypeptide binding]; other site 441771002621 TipAS antibiotic-recognition domain; Region: TipAS; pfam07739 441771002622 cobyric acid synthase; Provisional; Region: PRK00784 441771002623 The Fer4_NifH superfamily contains a variety of proteins which share a common ATP-binding domain. Functionally, proteins in this superfamily use the energy from hydrolysis of NTP to transfer electron or ion; Region: Fer4_NifH; cl17203 441771002624 Type 1 glutamine amidotransferase (GATase1) domain found in Cobyric Acid Synthase (CobQ); Region: GATase1_CobQ; cd01750 441771002625 catalytic triad [active] 441771002626 cobalamin biosynthesis protein; Provisional; Region: cobD; PRK01209 441771002627 Histidinol-phosphate/aromatic aminotransferase and cobyric acid decarboxylase [Amino acid transport and metabolism]; Region: HisC; COG0079 441771002628 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 441771002629 pyridoxal 5'-phosphate binding site [chemical binding]; other site 441771002630 homodimer interface [polypeptide binding]; other site 441771002631 catalytic residue [active] 441771002632 cobalt transport protein CbiM; Validated; Region: PRK08319 441771002633 cobalt transport protein CbiN; Provisional; Region: PRK02898 441771002634 Cobalt transport protein; Region: CbiQ; cl00463 441771002635 precorrin-2 dehydrogenase; Provisional; Region: PRK05562 441771002636 Putative NAD(P)-binding; Region: NAD_binding_7; pfam13241 441771002637 porphobilinogen deaminase; Reviewed; Region: hemC; PRK00072 441771002638 Hydroxymethylbilane synthase (HMBS), also known as porphobilinogen deaminase (PBGD), is an intermediate enzyme in the biosynthetic pathway of tetrapyrrolic ring systems, such as heme, chlorophylls, and vitamin B12. HMBS catalyzes the conversion of...; Region: HMBS; cd00494 441771002639 domain interfaces; other site 441771002640 active site 441771002641 Uroporphyrin-III C-methyltransferase (S-Adenosyl-L-methionine:uroporphyrinogen III methyltransferase, SUMT); Region: SUMT; cd11642 441771002642 active site 441771002643 SAM binding site [chemical binding]; other site 441771002644 homodimer interface [polypeptide binding]; other site 441771002645 Uroporphyrinogen-III synthase (HemD) catalyzes the asymmetrical cyclization of tetrapyrrole (linear) to uroporphyrinogen-III, the fourth step in the biosynthesis of heme. This ubiquitous enzyme is present in eukaryotes, bacteria and archaea. Mutations in...; Region: HemD; cd06578 441771002646 active site 441771002647 Porphobilinogen synthase (PBGS), which is also called delta-aminolevulinic acid dehydratase (ALAD), catalyzes the condensation of two 5-aminolevulinic acid (ALA) molecules to form the pyrrole porphobilinogen (PBG), which is the second step in the...; Region: ALAD_PBGS; cd00384 441771002648 dimer interface [polypeptide binding]; other site 441771002649 active site 441771002650 Schiff base residues; other site 441771002651 cobyrinic acid a,c-diamide synthase; Validated; Region: PRK01077 441771002652 The Fer4_NifH superfamily contains a variety of proteins which share a common ATP-binding domain. Functionally, proteins in this superfamily use the energy from hydrolysis of NTP to transfer electron or ion; Region: Fer4_NifH; cl17203 441771002653 Type 1 glutamine amidotransferase (GATase1) domain found in Cobyrinic Acid a,c-Diamide Synthase; Region: GATase1_CobB; cd03130 441771002654 catalytic triad [active] 441771002655 precorrin-8X methylmutase; Validated; Region: cbiC; PRK05575 441771002656 CAAX protease self-immunity; Region: Abi; pfam02517 441771002657 Multimeric flavodoxin WrbA [General function prediction only]; Region: WrbA; COG0655 441771002658 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 441771002659 Zn2+ binding site [ion binding]; other site 441771002660 Mg2+ binding site [ion binding]; other site 441771002661 Predicted transcriptional regulators [Transcription]; Region: SoxR; COG0789 441771002662 Helix-Turn-Helix DNA binding domain of MerR-like transcription regulators; Region: HTH_MerR-like; cd00592 441771002663 DNA binding residues [nucleotide binding] 441771002664 dimer interface [polypeptide binding]; other site 441771002665 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 441771002666 Coenzyme A binding pocket [chemical binding]; other site 441771002667 Fic family protein [Function unknown]; Region: COG3177 441771002668 Fic/DOC family; Region: Fic; pfam02661 441771002669 NAD(P)H:flavin oxidoreductase-like family 2. A subfamily of the nitroreductase family containing uncharacterized proteins that are similar to nitroreductase. Nitroreductase catalyzes the reduction of nitroaromatic compounds such as nitrotoluenes; Region: NADPH_oxidoreductase_2; cd02151 441771002670 putative FMN binding site [chemical binding]; other site 441771002671 GrpB protein; Region: GrpB; pfam04229 441771002672 cobalt-precorrin-6A synthase; Reviewed; Region: cbiD; PRK00075 441771002673 Precorrin-6Y methyltransferase, the cobalamin biosynthesis enzyme CbiE; Region: Precorrin-6Y-methylase; cd11644 441771002674 active site 441771002675 putative homodimer interface [polypeptide binding]; other site 441771002676 SAM binding site [chemical binding]; other site 441771002677 CAAX protease self-immunity; Region: Abi; pfam02517 441771002678 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 441771002679 S-adenosylmethionine binding site [chemical binding]; other site 441771002680 SdpI/YhfL protein family; Region: SdpI; pfam13630 441771002681 hypothetical protein; Provisional; Region: PRK06771 441771002682 Nicotinamidase_ related amidohydrolases. Cysteine hydrolases of unknown function that share the catalytic triad with other amidohydrolases, like nicotinamidase, which converts nicotinamide to nicotinic acid and ammonia; Region: nicotinamidase_related; cd01014 441771002683 catalytic triad [active] 441771002684 conserved cis-peptide bond; other site 441771002685 Precorrin-2 C20-methyltransferase, also named CobI or CbiL; Region: Precorrin_2_C20_MT; cd11645 441771002686 active site 441771002687 SAM binding site [chemical binding]; other site 441771002688 homodimer interface [polypeptide binding]; other site 441771002689 Precorrin-4 C11-methyltransferase (CbiF/CobM); Region: Precorrin-4_C11-MT; cd11641 441771002690 active site 441771002691 SAM binding site [chemical binding]; other site 441771002692 homodimer interface [polypeptide binding]; other site 441771002693 cobalamin biosynthesis protein CbiG; Validated; Region: PRK05788 441771002694 Cobalamin synthesis G N-terminal; Region: CbiG_N; pfam11760 441771002695 Cobalamin biosynthesis central region; Region: CbiG_mid; pfam11761 441771002696 Cobalamin synthesis G C-terminus; Region: CbiG_C; pfam01890 441771002697 Precorrin-3B C(17)-methyltransferase (CobJ/CbiH); Region: Precorrin_3B_C17_MT; cd11646 441771002698 active site 441771002699 SAM binding site [chemical binding]; other site 441771002700 homodimer interface [polypeptide binding]; other site 441771002701 cobalt-precorrin-6x reductase; Reviewed; Region: PRK08057 441771002702 Protein of unknown function (DUF3816); Region: DUF3816; pfam12822 441771002703 Cobalt chelatase (CbiK); Region: CbiK; pfam06180 441771002704 Anaerobic cobalamin biosynthetic cobalt chelatase (CbiK), N-terminal domain. CbiK is part of the cobalt-early path for cobalamin biosynthesis. It catalyzes the insertion of cobalt into the oxidized form of precorrin-2, factor II (sirohydrochlorin), the...; Region: CbiK_N; cd03412 441771002705 active site 441771002706 C-terminal domain interface [polypeptide binding]; other site 441771002707 Anaerobic cobalamin biosynthetic cobalt chelatase (CbiK), C-terminal domain. CbiK is part of the cobalt-early path for cobalamin biosynthesis. It catalyzes the insertion of cobalt into the oxidized form of precorrin-2, factor II (sirohydrochlorin), the...; Region: CbiK_C; cd03413 441771002708 active site 441771002709 N-terminal domain interface [polypeptide binding]; other site 441771002710 Protein involved in propanediol utilization, and related proteins (includes coumermycin biosynthetic protein), possible kinase [Secondary metabolites biosynthesis, transport, and catabolism]; Region: PduX; COG4542 441771002711 GHMP kinases N terminal domain; Region: GHMP_kinases_N; pfam00288 441771002712 ATP:corrinoid adenosyltransferase [Coenzyme metabolism]; Region: BtuR; COG2109 441771002713 ATP:corrinoid adenosyltransferase BtuR/CobO/CobP. This family consists of the BtuR, CobO, CobP proteins all of which are Cob(I)alamin (vitamin B12) adenosyltransferase, which is involved in cobalamin (vitamin B12) biosynthesis. This enzyme is a homodimer; Region: CobA_CobO_BtuR; cd00561 441771002714 homodimer interface [polypeptide binding]; other site 441771002715 Walker A motif; other site 441771002716 ATP binding site [chemical binding]; other site 441771002717 hydroxycobalamin binding site [chemical binding]; other site 441771002718 Walker B motif; other site 441771002719 cAMP-binding proteins - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases [Signal transduction mechanisms]; Region: Crp; COG0664 441771002720 effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038 441771002721 ligand binding site [chemical binding]; other site 441771002722 flexible hinge region; other site 441771002723 Crp-like helix-turn-helix domain; Region: HTH_Crp_2; pfam13545 441771002724 putative switch regulator; other site 441771002725 non-specific DNA interactions [nucleotide binding]; other site 441771002726 DNA binding site [nucleotide binding] 441771002727 sequence specific DNA binding site [nucleotide binding]; other site 441771002728 putative cAMP binding site [chemical binding]; other site 441771002729 Formate/nitrite transporter; Region: Form_Nir_trans; pfam01226 441771002730 anaerobic sulfite reductase subunit A; Provisional; Region: PRK15055 441771002731 sulfite reductase, subunit A; Region: sulfite_red_A; TIGR02910 441771002732 anaerobic sulfite reductase subunit B; Provisional; Region: PRK08221 441771002733 Anaerobic sulfite reductase contains an FAD and NADPH binding module with structural similarity to ferredoxin reductase and sequence similarity to dihydroorotate dehydrogenases. Clostridium pasteurianum inducible dissimilatory type sulfite reductase is...; Region: sulfite_reductase_like; cd06221 441771002734 FAD binding pocket [chemical binding]; other site 441771002735 FAD binding motif [chemical binding]; other site 441771002736 phosphate binding motif [ion binding]; other site 441771002737 beta-alpha-beta structure motif; other site 441771002738 NAD binding pocket [chemical binding]; other site 441771002739 Iron coordination center [ion binding]; other site 441771002740 sulfite reductase, subunit C; Region: sulfite_red_C; TIGR02912 441771002741 Nitrite/Sulfite reductase ferredoxin-like half domain; Region: NIR_SIR_ferr; pfam03460 441771002742 Nitrite and sulphite reductase 4Fe-4S domain; Region: NIR_SIR; pfam01077 441771002743 4Fe-4S dicluster domain; Region: Fer4_8; pfam13183 441771002744 4Fe-4S binding domain; Region: Fer4; pfam00037 441771002745 MoeA_like. This domain is similar to a domain found in a variety of proteins involved in biosynthesis of molybdopterin cofactor, like MoaB, MogA, and MoeA. There this domain is presumed to bind molybdopterin. The exact function of this subgroup is...; Region: MoeA_like; cd03522 441771002746 putative MPT binding site; other site 441771002747 ABC transporter, phosphonate, periplasmic substrate-binding protein; Region: Phosphonate-bd; cl19131 441771002748 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 441771002749 substrate binding pocket [chemical binding]; other site 441771002750 membrane-bound complex binding site; other site 441771002751 hinge residues; other site 441771002752 ABC-type sulfate transport system, permease component [Posttranslational modification, protein turnover, chaperones]; Region: CysU; COG0555 441771002753 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 441771002754 dimer interface [polypeptide binding]; other site 441771002755 conserved gate region; other site 441771002756 putative PBP binding loops; other site 441771002757 ABC-ATPase subunit interface; other site 441771002758 ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136 441771002759 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 441771002760 Walker A/P-loop; other site 441771002761 ATP binding site [chemical binding]; other site 441771002762 Q-loop/lid; other site 441771002763 ABC transporter signature motif; other site 441771002764 Walker B; other site 441771002765 D-loop; other site 441771002766 H-loop/switch region; other site 441771002767 Uncharacterized conserved protein [Function unknown]; Region: COG2014 441771002768 Domain of unknown function (DUF364); Region: DUF364; pfam04016 441771002769 ABC-2 family transporter protein; Region: ABC2_membrane_4; pfam12730 441771002770 ABC-type multidrug transport system, ATPase component [Defense mechanisms]; Region: CcmA; COG1131 441771002771 ABC-type multidrug transport system, ATPase component; Region: ABC_drug_resistance_like; cd03264 441771002772 Walker A/P-loop; other site 441771002773 ATP binding site [chemical binding]; other site 441771002774 Q-loop/lid; other site 441771002775 ABC transporter signature motif; other site 441771002776 Walker B; other site 441771002777 D-loop; other site 441771002778 H-loop/switch region; other site 441771002779 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 441771002780 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 441771002781 active site 441771002782 phosphorylation site [posttranslational modification] 441771002783 intermolecular recognition site; other site 441771002784 dimerization interface [polypeptide binding]; other site 441771002785 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 441771002786 DNA binding site [nucleotide binding] 441771002787 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 441771002788 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 441771002789 dimer interface [polypeptide binding]; other site 441771002790 phosphorylation site [posttranslational modification] 441771002791 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 441771002792 ATP binding site [chemical binding]; other site 441771002793 Mg2+ binding site [ion binding]; other site 441771002794 G-X-G motif; other site 441771002795 ABC-type cobalamin/Fe3+-siderophores transport systems, ATPase components [Inorganic ion transport and metabolism / Coenzyme metabolism]; Region: FepC; COG1120 441771002796 ATP-binding component of iron-siderophores, vitamin B12 and hemin transporters and related proteins; Region: ABC_Iron-Siderophores_B12_Hemin; cd03214 441771002797 Walker A/P-loop; other site 441771002798 ATP binding site [chemical binding]; other site 441771002799 Q-loop/lid; other site 441771002800 ABC transporter signature motif; other site 441771002801 Walker B; other site 441771002802 D-loop; other site 441771002803 H-loop/switch region; other site 441771002804 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550 441771002805 ABC-ATPase subunit interface; other site 441771002806 dimer interface [polypeptide binding]; other site 441771002807 putative PBP binding regions; other site 441771002808 Metal binding protein TroA_a. These proteins are predicted to function as initial receptors in ABC transport of metal ions in eubacteria. They belong to the TroA superfamily of helical backbone metal receptor proteins that share a distinct fold and...; Region: TroA_a; cd01148 441771002809 Periplasmic binding protein; Region: Peripla_BP_2; pfam01497 441771002810 putative ligand binding residues [chemical binding]; other site 441771002811 dihydroxyacetone kinase; Provisional; Region: PRK14479 441771002812 dihydroxyacetone kinase subunit DhaK; Provisional; Region: PRK14481 441771002813 DAK2 domain; Region: Dak2; pfam02734 441771002814 Glycerol dehydrogenases (GlyDH) catalyzes oxidation of glycerol to dihydroxyacetone in glycerol dissmilation; Region: GlyDH; cd08170 441771002815 dimer interface [polypeptide binding]; other site 441771002816 active site 441771002817 metal binding site [ion binding]; metal-binding site 441771002818 Sensory domain found in PocR; Region: PocR; pfam10114 441771002819 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 441771002820 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 441771002821 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 441771002822 Acetyltransferase (GNAT) domain; Region: Acetyltransf_10; pfam13673 441771002823 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 441771002824 Coenzyme A binding pocket [chemical binding]; other site 441771002825 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 441771002826 Acetyltransferases [General function prediction only]; Region: RimI; COG0456 441771002827 Coenzyme A binding pocket [chemical binding]; other site 441771002828 Protein of unknown function (DUF1349); Region: DUF1349; pfam07081 441771002829 Protein of unknown function (DUF3788); Region: DUF3788; pfam12663 441771002830 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 441771002831 active site 441771002832 catalytic tetrad [active] 441771002833 TfoX N-terminal domain; Region: TfoX_N; pfam04993 441771002834 Acetyltransferases [General function prediction only]; Region: RimI; COG0456 441771002835 Acetyltransferase (GNAT) family; Region: Acetyltransf_1; pfam00583 441771002836 Protein of unknown function (DUF1462); Region: DUF1462; cl11552 441771002837 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 441771002838 Coenzyme A binding pocket [chemical binding]; other site 441771002839 Transcriptional regulators [Transcription]; Region: MarR; COG1846 441771002840 Predicted transcriptional regulators [Transcription]; Region: COG1695 441771002841 Protein of unknown function (DUF2812); Region: DUF2812; pfam11193 441771002842 Adenosine deaminase (ADA) is a monomeric zinc dependent enzyme which catalyzes the irreversible hydrolytic deamination of both adenosine, as well as desoxyadenosine, to ammonia and inosine or desoxyinosine, respectively. ADA plays an important role in...; Region: ADA; cd01320 441771002843 active site 441771002844 purine riboside binding site [chemical binding]; other site 441771002845 Predicted membrane protein [Function unknown]; Region: COG1511 441771002846 YhgE/Pip N-terminal domain; Region: pip_yhgE_Nterm; cl19580 441771002847 Flagella accessory protein C (FlaC); Region: FlaC_arch; cl10488 441771002848 YhgE/Pip C-terminal domain; Region: pip_yhgE_Cterm; TIGR03062 441771002849 Predicted membrane protein [Function unknown]; Region: COG1511 441771002850 YhgE/Pip N-terminal domain; Region: pip_yhgE_Nterm; cl19580 441771002851 Fibrinogen alpha/beta chain family; Region: Fib_alpha; pfam08702 441771002852 YhgE/Pip C-terminal domain; Region: pip_yhgE_Cterm; TIGR03062 441771002853 Domain of unknown function (DUF4184); Region: DUF4184; pfam13803 441771002854 ATP-dependent DNA helicase RecQ; Region: recQ; TIGR01389 441771002855 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 441771002856 ATP binding site [chemical binding]; other site 441771002857 putative Mg++ binding site [ion binding]; other site 441771002858 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 441771002859 nucleotide binding region [chemical binding]; other site 441771002860 ATP-binding site [chemical binding]; other site 441771002861 This DNA-binding domain is found in the RecQ helicase among others and has a helix-turn-helix structure; Region: RQC; smart00956 441771002862 HRDC domain; Region: HRDC; pfam00570 441771002863 Helix-turn-helix domain; Region: HTH_40; pfam14493 441771002864 rubrerythrin-like, diiron-binding domain; Region: Rubrerythrin_like; cd01046 441771002865 Rubrerythrin [Energy production and conversion]; Region: COG1592 441771002866 diiron binding motif [ion binding]; other site 441771002867 Escherichia coli YfcE and related proteins, metallophosphatase domain; Region: MPP_YfcE; cd00841 441771002868 active site 441771002869 metal binding site [ion binding]; metal-binding site 441771002870 homotetramer interface [polypeptide binding]; other site 441771002871 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 441771002872 active site 441771002873 phosphorylation site [posttranslational modification] 441771002874 intermolecular recognition site; other site 441771002875 dimerization interface [polypeptide binding]; other site 441771002876 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 441771002877 TPR repeat; Region: TPR_11; pfam13414 441771002878 TPR motif; other site 441771002879 binding surface 441771002880 WG containing repeat; Region: WG_beta_rep; pfam14903 441771002881 WG containing repeat; Region: WG_beta_rep; pfam14903 441771002882 WG containing repeat; Region: WG_beta_rep; pfam14903 441771002883 Domain of unknown function (DUF4163); Region: DUF4163; pfam13739 441771002884 Protein of unknown function (DUF3298); Region: DUF3298; pfam11738 441771002885 Protein of unknown function (DUF2997); Region: DUF2997; pfam11211 441771002886 putative membrane protein, TIGR04086 family; Region: TIGR04086_membr 441771002887 Helix-hairpin-helix motif; Region: HHH_3; pfam12836 441771002888 4Fe-4S single cluster domain; Region: Fer4_12; pfam13353 441771002889 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 441771002890 FeS/SAM binding site; other site 441771002891 Ycf46; Provisional; Region: ycf46; CHL00195 441771002892 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 441771002893 Walker A motif; other site 441771002894 ATP binding site [chemical binding]; other site 441771002895 Walker B motif; other site 441771002896 arginine finger; other site 441771002897 L-lactate permease [Energy production and conversion]; Region: LldP; COG1620 441771002898 Domain of unknown function (DUF2088); Region: DUF2088; cl15406 441771002899 The electron transfer flavoprotein (ETF) serves as a specific electron acceptor for various mitochondrial dehydrogenases. ETF transfers electrons to the main respiratory chain via ETF-ubiquinone oxidoreductase. ETF is an heterodimer that consists of an...; Region: ETF_beta; cd01714 441771002900 Ligand binding site [chemical binding]; other site 441771002901 Ferredoxin [Energy production and conversion]; Region: NapF; COG1145 441771002902 Electron transfer flavoprotein, alpha subunit [Energy production and conversion]; Region: FixB; COG2025 441771002903 The electron transfer flavoprotein (ETF) serves as a specific electron acceptor for various mitochondrial dehydrogenases. ETF transfers electrons to the main respiratory chain via ETF-ubiquinone oxidoreductase. ETF is an heterodimer that consists of an...; Region: ETF_alpha; cd01715 441771002904 Electron transfer flavoprotein FAD-binding domain; Region: ETF_alpha; pfam00766 441771002905 FAD/FMN-containing dehydrogenases [Energy production and conversion]; Region: GlcD; COG0277 441771002906 FAD binding domain; Region: FAD_binding_4; pfam01565 441771002907 FAD linked oxidases, C-terminal domain; Region: FAD-oxidase_C; pfam02913 441771002908 Domain of unknown function (DUF4098); Region: DUF4098; cl19992 441771002909 Transcriptional regulators [Transcription]; Region: MarR; COG1846 441771002910 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cl17220 441771002911 putative DNA binding site [nucleotide binding]; other site 441771002912 putative Zn2+ binding site [ion binding]; other site 441771002913 Putative cyclase; Region: Cyclase; pfam04199 441771002914 aspartate aminotransferase; Provisional; Region: PRK06836 441771002915 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 441771002916 pyridoxal 5'-phosphate binding site [chemical binding]; other site 441771002917 homodimer interface [polypeptide binding]; other site 441771002918 catalytic residue [active] 441771002919 Putative cyclase; Region: Cyclase; pfam04199 441771002920 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cl17220 441771002921 Transcriptional regulators [Transcription]; Region: MarR; COG1846 441771002922 Predicted transcriptional regulators [Transcription]; Region: SoxR; COG0789 441771002923 Helix-Turn-Helix DNA binding domain of the BmrR transcription regulator; Region: HTH_BmrR; cd01107 441771002924 DNA binding residues [nucleotide binding] 441771002925 drug binding residues [chemical binding]; other site 441771002926 dimer interface [polypeptide binding]; other site 441771002927 Transcriptional regulator, effector-binding domain/component [Transcription / Signal transduction mechanisms]; Region: COG4978 441771002928 B3/4 domain; Region: B3_4; cl19243 441771002929 aspartyl-tRNA synthetase; Provisional; Region: aspC; PRK05159 441771002930 Asp_Lys_Asn_RS_N: N-terminal, anticodon recognition domain of class 2b aminoacyl-tRNA synthetases (aaRSs). This domain is a beta-barrel domain (OB fold) involved in binding the tRNA anticodon stem-loop. Class 2b aaRSs include the homodimeric aspartyl-; Region: Asp_Lys_Asn_RS_N; cl19106 441771002931 Dimer interface [polypeptide binding]; other site 441771002932 anticodon binding site; other site 441771002933 Asx tRNA synthetase (AspRS/AsnRS) class II core domain. Assignment to class II aminoacyl-tRNA synthetases (aaRS) based upon its structure and the presence of three characteristic sequence motifs in the core domain. This family includes AsnRS as well as...; Region: AsxRS_core; cd00776 441771002934 homodimer interface [polypeptide binding]; other site 441771002935 motif 1; other site 441771002936 motif 2; other site 441771002937 active site 441771002938 motif 3; other site 441771002939 Flavodoxin domain; Region: Flavodoxin_5; cl17428 441771002940 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 441771002941 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 441771002942 WHG domain; Region: WHG; pfam13305 441771002943 Flavodoxin domain; Region: Flavodoxin_5; pfam12724 441771002944 HAD-hyrolase-like; Region: Hydrolase_like; cl19142 441771002945 HAD superfamily (subfamily IA) hydrolase, TIGR02254; Region: YjjG/YfnB 441771002946 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 441771002947 motif II; other site 441771002948 DNA-binding transcriptional activator YeiL; Provisional; Region: PRK10402 441771002949 effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038 441771002950 ligand binding site [chemical binding]; other site 441771002951 flexible hinge region; other site 441771002952 Crp-like helix-turn-helix domain; Region: HTH_Crp_2; pfam13545 441771002953 putative switch regulator; other site 441771002954 DNA binding site [nucleotide binding] 441771002955 sequence specific DNA binding site [nucleotide binding]; other site 441771002956 putative cAMP binding site [chemical binding]; other site 441771002957 DJ-1 family protein; Region: not_thiJ; TIGR01383 441771002958 Type 1 glutamine amidotransferase (GATase1)-like domain found in Human DJ-1; Region: GATase1_DJ-1; cd03135 441771002959 conserved cys residue [active] 441771002960 Transcriptional regulator [Transcription]; Region: LysR; COG0583 441771002961 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 441771002962 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cd05466 441771002963 dimerization interface [polypeptide binding]; other site 441771002964 YoaP-like; Region: YoaP; pfam14268 441771002965 FeoA domain; Region: FeoA; pfam04023 441771002966 Fe2+ transport system protein A [Inorganic ion transport and metabolism]; Region: FeoA; COG1918 441771002967 Fe2+ transport system protein B [Inorganic ion transport and metabolism]; Region: FeoB; COG0370 441771002968 Ferrous iron transport protein B (FeoB) family; Region: FeoB; cd01879 441771002969 G1 box; other site 441771002970 GTP/Mg2+ binding site [chemical binding]; other site 441771002971 Switch I region; other site 441771002972 G2 box; other site 441771002973 G3 box; other site 441771002974 Switch II region; other site 441771002975 G4 box; other site 441771002976 G5 box; other site 441771002977 Nucleoside recognition; Region: Gate; pfam07670 441771002978 Ferrous iron transport protein B C terminus; Region: FeoB_C; pfam07664 441771002979 Nucleoside recognition; Region: Gate; pfam07670 441771002980 Acetyltransferase (GNAT) domain; Region: Acetyltransf_10; pfam13673 441771002981 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 441771002982 Coenzyme A binding pocket [chemical binding]; other site 441771002983 D-alanyl-D-alanine carboxypeptidase [Cell envelope biogenesis, outer membrane]; Region: VanY; COG1876 441771002984 D-alanyl-D-alanine carboxypeptidase; Region: VanY; pfam02557 441771002985 small acid-soluble spore protein Tlp; Provisional; Region: PRK03830 441771002986 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 441771002987 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 441771002988 active site 441771002989 phosphorylation site [posttranslational modification] 441771002990 intermolecular recognition site; other site 441771002991 dimerization interface [polypeptide binding]; other site 441771002992 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 441771002993 DNA binding site [nucleotide binding] 441771002994 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 441771002995 dimer interface [polypeptide binding]; other site 441771002996 phosphorylation site [posttranslational modification] 441771002997 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 441771002998 ATP binding site [chemical binding]; other site 441771002999 Mg2+ binding site [ion binding]; other site 441771003000 G-X-G motif; other site 441771003001 Cytochrome P450 [Secondary metabolites biosynthesis, transport, and catabolism]; Region: CypX; COG2124 441771003002 Heavy-metal-associated domain (HMA) is a conserved domain of approximately 30 amino acid residues found in a number of proteins that transport or detoxify heavy metals, for example, the CPx-type heavy metal ATPases and copper chaperones. HMA domain...; Region: HMA; cd00371 441771003003 metal-binding site [ion binding] 441771003004 Cytochrome C biogenesis protein transmembrane region; Region: DsbD_2; pfam13386 441771003005 Cupredoxin-like domain; Region: Cupredoxin_1; cl17234 441771003006 Plastocyanin domain containing protein [General function prediction only]; Region: COG4633 441771003007 Flagellar biosynthesis protein, FliO; Region: FliO; cl01247 441771003008 Short C-terminal domain; Region: SHOCT; pfam09851 441771003009 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 441771003010 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 441771003011 active site 441771003012 phosphorylation site [posttranslational modification] 441771003013 intermolecular recognition site; other site 441771003014 dimerization interface [polypeptide binding]; other site 441771003015 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 441771003016 DNA binding site [nucleotide binding] 441771003017 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 441771003018 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 441771003019 dimerization interface [polypeptide binding]; other site 441771003020 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 441771003021 dimer interface [polypeptide binding]; other site 441771003022 phosphorylation site [posttranslational modification] 441771003023 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 441771003024 ATP binding site [chemical binding]; other site 441771003025 Mg2+ binding site [ion binding]; other site 441771003026 G-X-G motif; other site 441771003027 A new structural DNA glycosylase; Region: AlkD_like; cd06561 441771003028 active site 441771003029 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 441771003030 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 441771003031 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 441771003032 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550 441771003033 ABC-ATPase subunit interface; other site 441771003034 dimer interface [polypeptide binding]; other site 441771003035 putative PBP binding regions; other site 441771003036 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550 441771003037 ABC-ATPase subunit interface; other site 441771003038 dimer interface [polypeptide binding]; other site 441771003039 putative PBP binding regions; other site 441771003040 ABC-type enterochelin transport system, ATPase component [Inorganic ion transport and metabolism]; Region: CeuD; COG4604 441771003041 ATP-binding component of iron-siderophores, vitamin B12 and hemin transporters and related proteins; Region: ABC_Iron-Siderophores_B12_Hemin; cd03214 441771003042 Walker A/P-loop; other site 441771003043 ATP binding site [chemical binding]; other site 441771003044 Q-loop/lid; other site 441771003045 ABC transporter signature motif; other site 441771003046 Walker B; other site 441771003047 D-loop; other site 441771003048 H-loop/switch region; other site 441771003049 ABC-type Fe3+-hydroxamate transport system, periplasmic component [Inorganic ion transport and metabolism]; Region: FepB; COG0614 441771003050 Siderophore binding protein FatB. These proteins have been shown to function as ABC-type initial receptors in the siderophore-mediated iron uptake in some eubacterial species. They belong to the TroA superfamily of periplasmic metal binding proteins...; Region: FatB; cd01140 441771003051 putative ligand binding residues [chemical binding]; other site 441771003052 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 441771003053 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 441771003054 ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132 441771003055 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 441771003056 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 441771003057 Walker A/P-loop; other site 441771003058 ATP binding site [chemical binding]; other site 441771003059 Q-loop/lid; other site 441771003060 ABC transporter signature motif; other site 441771003061 Walker B; other site 441771003062 D-loop; other site 441771003063 H-loop/switch region; other site 441771003064 ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132 441771003065 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 441771003066 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 441771003067 Walker A/P-loop; other site 441771003068 ATP binding site [chemical binding]; other site 441771003069 Q-loop/lid; other site 441771003070 ABC transporter signature motif; other site 441771003071 Walker B; other site 441771003072 D-loop; other site 441771003073 H-loop/switch region; other site 441771003074 Predicted signal transduction protein with a C-terminal ATPase domain [Signal transduction mechanisms]; Region: COG2972 441771003075 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 441771003076 ATP binding site [chemical binding]; other site 441771003077 Mg2+ binding site [ion binding]; other site 441771003078 G-X-G motif; other site 441771003079 Response regulator of the LytR/AlgR family [Transcription / Signal transduction mechanisms]; Region: LytT; COG3279 441771003080 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 441771003081 active site 441771003082 phosphorylation site [posttranslational modification] 441771003083 intermolecular recognition site; other site 441771003084 dimerization interface [polypeptide binding]; other site 441771003085 LytTr DNA-binding domain; Region: LytTR; smart00850 441771003086 Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013 441771003087 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 441771003088 Carboxypeptidase regulatory-like domain; Region: CarboxypepD_reg; pfam13620 441771003089 conserved repeat domain; Region: B_ant_repeat; TIGR01451 441771003090 S-layer domain [Cell envelope biogenesis, outer membrane]; Region: COG1361 441771003091 Domain of unknown function DUF11; Region: DUF11; pfam01345 441771003092 Domain of unknown function DUF11; Region: DUF11; pfam01345 441771003093 Domain of unknown function DUF11; Region: DUF11; pfam01345 441771003094 GH18 domain of Chitinase D (ChiD). ChiD, a chitinase found in Bacillus circulans, hydrolyzes the 1,4-beta-linkages of N-acetylglucosamine in chitin and chitodextrins. The domain architecture of ChiD includes a catalytic glycosyl hydrolase family 18; Region: GH18_chitinase_D-like; cd02871 441771003095 Glycosyl hydrolases family 18; Region: Glyco_hydro_18; pfam00704 441771003096 putative active site [active] 441771003097 Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all...; Region: FN3; cd00063 441771003098 Interdomain contacts; other site 441771003099 Cytokine receptor motif; other site 441771003100 chitin-binding domain of Chi A1-like proteins; Region: ChiA1_BD; cd12214 441771003101 Highly conserved protein containing a thioredoxin domain [Posttranslational modification, protein turnover, chaperones]; Region: COG1331 441771003102 TRX domain, SSP411 protein family; members of this family are highly conserved proteins present in eukaryotes, bacteria and archaea, about 600-800 amino acids in length, which contain a TRX domain with a redox active CXXC motif. The human/rat protein; Region: SSP411; cd02955 441771003103 catalytic residues [active] 441771003104 LanC-like proteins. LanC is the cyclase enzyme of the lanthionine synthetase. Lanthionine is a lantibiotic, a unique class of peptide antibiotics. They are ribosomally synthesized as a precursor peptide and then post-translationally modified to contain...; Region: LanC_like; cl04955 441771003105 Predicted membrane protein [Function unknown]; Region: COG4129 441771003106 Bacterial protein of unknown function (DUF939); Region: DUF939; pfam06081 441771003107 DUF939 C-terminal domain; Region: DUF939_C; pfam11728 441771003108 Aminoglycoside 3'-phosphotransferase (APH) and Choline Kinase (ChoK) family. The APH/ChoK family is part of a larger superfamily that includes the catalytic domains of other kinases, such as the typical serine/threonine/tyrosine protein kinases (PKs)...; Region: APH_ChoK_like; cl17270 441771003109 Serine/threonine protein kinase [General function prediction only / Signal transduction mechanisms / Transcription / DNA replication, recombination, and repair]; Region: SPS1; COG0515 441771003110 CAAX protease self-immunity; Region: Abi; pfam02517 441771003111 Metal-dependent hydrolases of the beta-lactamase superfamily II [General function prediction only]; Region: COG1237 441771003112 ATPase components of ABC transporters with duplicated ATPase domains [General function prediction only]; Region: Uup; COG0488 441771003113 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 441771003114 ABC transporter; Region: ABC_tran_2; pfam12848 441771003115 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 441771003116 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3314 441771003117 Nucleoside recognition; Region: Gate; pfam07670 441771003118 Arsenate Reductase (ArsC) family; composed of TRX-fold arsenic reductases and similar proteins including the transcriptional regulator, Spx. ArsC catalyzes the reduction of arsenate [As(V)] to arsenite [As(III)], using reducing equivalents derived from...; Region: ArsC_family; cd02977 441771003119 catalytic residue [active] 441771003120 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 441771003121 FeS/SAM binding site; other site 441771003122 Iron-sulfur cluster-binding domain; Region: SPASM; pfam13186 441771003123 Predicted dehydrogenase [General function prediction only]; Region: COG0579 441771003124 hydroxyglutarate oxidase; Provisional; Region: PRK11728; cl19156 441771003125 BFD-like [2Fe-2S] binding domain; Region: Fer2_BFD; pfam04324 441771003126 thioredoxin-disulfide reductase; Region: TRX_reduct; TIGR01292 441771003127 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl19134 441771003128 Molybdopterin-Binding (MopB) domain of the MopB superfamily of proteins, a large, diverse, heterogeneous superfamily of enzymes that, in general, bind molybdopterin as a cofactor. The MopB domain is found in a wide variety of molybdenum- and...; Region: Molybdopterin-Binding; cl09928 441771003129 Protein of unknown function (DUF1667); Region: DUF1667; pfam07892 441771003130 sn-glycerol-3-phosphate transporter; Provisional; Region: glpT; PRK11273 441771003131 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 441771003132 putative substrate translocation pore; other site 441771003133 arginyl-tRNA synthetase; Reviewed; Region: PRK12451 441771003134 Arginyl tRNA synthetase N terminal domain; Region: Arg_tRNA_synt_N; pfam03485 441771003135 catalytic core domain of arginyl-tRNA synthetases; Region: ArgRS_core; cd00671 441771003136 active site 441771003137 HIGH motif; other site 441771003138 KMSK motif region; other site 441771003139 Anticodon-binding domain of arginyl tRNA synthetases; Region: Anticodon_Ia_Arg; cd07956 441771003140 tRNA binding surface [nucleotide binding]; other site 441771003141 anticodon binding site; other site 441771003142 capreomycidine synthase; Region: viomycin_VioD; TIGR03947 441771003143 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 441771003144 pyridoxal 5'-phosphate binding site [chemical binding]; other site 441771003145 homodimer interface [polypeptide binding]; other site 441771003146 catalytic residue [active] 441771003147 FOG: CBS domain [General function prediction only]; Region: COG0517 441771003148 The CBS domain, named after human CBS, is a small domain originally identified in cystathionine beta-synthase and is subsequently found in a wide range of different proteins. CBS domains usually occur in tandem repeats. They associate to form a so-called...; Region: CBS_pair; cd02205 441771003149 Virus attachment protein p12 family; Region: P12; pfam12669 441771003150 Fe2+ transport system protein B [Inorganic ion transport and metabolism]; Region: FeoB; COG0370 441771003151 Ferrous iron transport protein B (FeoB) family; Region: FeoB; cd01879 441771003152 G1 box; other site 441771003153 GTP/Mg2+ binding site [chemical binding]; other site 441771003154 Switch I region; other site 441771003155 G2 box; other site 441771003156 G3 box; other site 441771003157 Switch II region; other site 441771003158 G4 box; other site 441771003159 G5 box; other site 441771003160 Nucleoside recognition; Region: Gate; pfam07670 441771003161 Ferrous iron transport protein B C terminus; Region: FeoB_C; pfam07664 441771003162 Nucleoside recognition; Region: Gate; pfam07670 441771003163 Fe2+ transport system protein A [Inorganic ion transport and metabolism]; Region: FeoA; COG1918 441771003164 PilZ domain; Region: PilZ; pfam07238 441771003165 HAD-superfamily subfamily IB hydrolase, TIGR01490; Region: HAD-SF-IB-hyp1 441771003166 haloacid dehalogenase-like hydrolase; Region: Hydrolase; pfam00702 441771003167 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 441771003168 motif II; other site 441771003169 PF-ChiA is an uncharacterized chitinase found in the hyperthermophilic archaeon Pyrococcus furiosus with a glycosyl hydrolase family 18 (GH18) catalytic domain as well as a cellulose-binding domain. Members of this domain family are found not only in...; Region: GH18_PF-ChiA-like; cd06543 441771003170 active site 441771003171 Glycosyl hydrolases family 18; Region: Glyco_hydro_18; pfam00704 441771003172 Chitin-binding domain of chitinase C; Region: ChiC_BD; cd12215 441771003173 aromatic chitin/cellulose binding site residues [chemical binding]; other site 441771003174 Chitin-binding domain of chitinase C; Region: ChiC_BD; cd12215 441771003175 aromatic chitin/cellulose binding site residues [chemical binding]; other site 441771003176 ABC-type metal ion transport system, ATPase component [Inorganic ion transport and metabolism]; Region: AbcC; COG1135 441771003177 ATP-binding cassette domain of methionine transporter; Region: ABC_MetN_methionine_transporter; cd03258 441771003178 Walker A/P-loop; other site 441771003179 ATP binding site [chemical binding]; other site 441771003180 Q-loop/lid; other site 441771003181 ABC transporter signature motif; other site 441771003182 Walker B; other site 441771003183 D-loop; other site 441771003184 H-loop/switch region; other site 441771003185 NIL domain; Region: NIL; pfam09383 441771003186 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 441771003187 dimer interface [polypeptide binding]; other site 441771003188 conserved gate region; other site 441771003189 putative PBP binding loops; other site 441771003190 ABC-ATPase subunit interface; other site 441771003191 ABC-type metal ion transport system, periplasmic component/surface antigen [Inorganic ion transport and metabolism]; Region: NlpA; COG1464 441771003192 ABC-type metal ion transport system, periplasmic component/surface antigen [Inorganic ion transport and metabolism]; Region: NlpA; COG1464 441771003193 ABC-type phosphate/phosphonate transport system, periplasmic component [Inorganic ion transport and metabolism]; Region: PhnD; COG3221 441771003194 Metal-dependent amidase/aminoacylase/carboxypeptidase [General function prediction only]; Region: AbgB; COG1473 441771003195 M20 Peptidase Aminoacylase 1 subfamily; Region: M20_Acy1_subfamily5; cd08019 441771003196 metal binding site [ion binding]; metal-binding site 441771003197 putative dimer interface [polypeptide binding]; other site 441771003198 RNase_H superfamily; Region: RNase_H_2; pfam13482 441771003199 Transcriptional regulators [Transcription]; Region: FadR; COG2186 441771003200 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 441771003201 DNA-binding site [nucleotide binding]; DNA binding site 441771003202 This entry represents the C-terminal ligand binding domain of many members of the GntR family; Region: FCD; smart00895 441771003203 Uncharacterized conserved protein [Function unknown]; Region: COG1284 441771003204 Uncharacterized BCR, YitT family COG1284; Region: DUF161; pfam02588 441771003205 Uncharacterized BCR, YitT family COG1284; Region: DUF161; pfam02588 441771003206 Uncharacterized protein conserved in bacteria (DUF2179); Region: DUF2179; pfam10035 441771003207 glutamyl-tRNA synthetase; Reviewed; Region: gltX; PRK01406 441771003208 catalytic core domain of discriminating glutamyl-tRNA synthetase; Region: GluRS_core; cd00808 441771003209 active site 441771003210 HIGH motif; other site 441771003211 KMSKS motif; other site 441771003212 glyceraldehyde-3-phosphate dehydrogenase; Validated; Region: PRK07729 441771003213 Glyceraldehyde 3-phosphate dehydrogenase, NAD binding domain; Region: Gp_dh_N; smart00846 441771003214 Glyceraldehyde 3-phosphate dehydrogenase, C-terminal domain; Region: Gp_dh_C; pfam02800 441771003215 Predicted exonuclease of the beta-lactamase fold involved in RNA processing [Translation, ribosomal structure and biogenesis]; Region: YSH1; COG1236 441771003216 Metallo-beta-lactamase superfamily; Region: Lactamase_B; smart00849 441771003217 Beta-Casp domain; Region: Beta-Casp; smart01027 441771003218 RNA-metabolizing metallo-beta-lactamase; Region: RMMBL; pfam07521 441771003219 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 441771003220 Zn2+ binding site [ion binding]; other site 441771003221 Mg2+ binding site [ion binding]; other site 441771003222 Bacillus subtilis aldehyde dehydrogenase ywdH-like; Region: ALDH_YwdH-P39616; cd07136 441771003223 NAD(P) binding site [chemical binding]; other site 441771003224 catalytic residues [active] 441771003225 Na+/alanine symporter [Amino acid transport and metabolism]; Region: AlsT; COG1115 441771003226 Na+/alanine symporter [Amino acid transport and metabolism]; Region: AlsT; COG1115 441771003227 Transcriptional regulators [Transcription]; Region: MarR; COG1846 441771003228 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cl17220 441771003229 putative DNA binding site [nucleotide binding]; other site 441771003230 putative Zn2+ binding site [ion binding]; other site 441771003231 Na+-driven multidrug efflux pump [Defense mechanisms]; Region: NorM; COG0534 441771003232 Subfamily of the multidrug and toxic compound extrusion (MATE)-like proteins similar to Streptococcus aureus MepA; Region: MATE_MepA_like; cd13143 441771003233 CHAT domain; Region: CHAT; cl19248 441771003234 Tetratricopeptide repeat; Region: TPR_12; pfam13424 441771003235 Coronavirus S2 glycoprotein; Region: Corona_S2; pfam01601 441771003236 Protein of unknown function (DUF2971); Region: DUF2971; pfam11185 441771003237 hypothetical protein; Provisional; Region: PRK11622 441771003238 ABC-type sulfate transport system, permease component [Posttranslational modification, protein turnover, chaperones]; Region: CysU; COG0555 441771003239 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 441771003240 dimer interface [polypeptide binding]; other site 441771003241 putative PBP binding loops; other site 441771003242 ABC-ATPase subunit interface; other site 441771003243 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 441771003244 dimer interface [polypeptide binding]; other site 441771003245 conserved gate region; other site 441771003246 putative PBP binding loops; other site 441771003247 ABC-ATPase subunit interface; other site 441771003248 ABC-type spermidine/putrescine transport systems, ATPase components [Amino acid transport and metabolism]; Region: PotA; COG3842 441771003249 ATP-binding cassette domain of the carbohydrate and solute transporters-like; Region: ABC_Carb_Solutes_like; cd03259 441771003250 Walker A/P-loop; other site 441771003251 ATP binding site [chemical binding]; other site 441771003252 Q-loop/lid; other site 441771003253 ABC transporter signature motif; other site 441771003254 Walker B; other site 441771003255 D-loop; other site 441771003256 H-loop/switch region; other site 441771003257 Uncharacterized conserved protein (DUF2156); Region: DUF2156; cl12090 441771003258 Acetyltransferases, including N-acetylases of ribosomal proteins [Translation, ribosomal structure and biogenesis]; Region: RimL; COG1670 441771003259 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 441771003260 Coenzyme A binding pocket [chemical binding]; other site 441771003261 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl17182 441771003262 TRX family; composed of two groups: Group I, which includes proteins that exclusively encode a TRX domain; and Group II, which are composed of fusion proteins of TRX and additional domains. Group I TRX is a small ancient protein that alter the redox...; Region: TRX_family; cd02947 441771003263 catalytic residues [active] 441771003264 Membrane protein of unknown function (DUF340); Region: DUF340; pfam03956 441771003265 maltose O-acetyltransferase; Provisional; Region: PRK10092 441771003266 Maltose O-acetyltransferase (MAT) and Galactoside O-acetyltransferase (GAT): MAT and GAT catalyze the CoA-dependent acetylation of the 6-hydroxyl group of their respective sugar substrates. MAT acetylates maltose and glucose exclusively at the C6...; Region: LbH_MAT_GAT; cd03357 441771003267 active site 441771003268 substrate binding site [chemical binding]; other site 441771003269 trimer interface [polypeptide binding]; other site 441771003270 CoA binding site [chemical binding]; other site 441771003271 Biotin operon repressor [Transcription]; Region: BirA; COG1654 441771003272 Biotin-(acetyl-CoA carboxylase) ligase [Coenzyme metabolism]; Region: BirA; COG0340 441771003273 Biotin/lipoate A/B protein ligase family; Region: BPL_LplA_LipB; cl14057 441771003274 Biotin protein ligase C terminal domain; Region: BPL_C; pfam02237 441771003275 Heavy-metal-associated domain (HMA) is a conserved domain of approximately 30 amino acid residues found in a number of proteins that transport or detoxify heavy metals, for example, the CPx-type heavy metal ATPases and copper chaperones. HMA domain...; Region: HMA; cd00371 441771003276 metal-binding site [ion binding] 441771003277 The CBS domain, named after human CBS, is a small domain originally identified in cystathionine beta-synthase and is subsequently found in a wide range of different proteins. CBS domains usually occur in tandem repeats. They associate to form a so-called...; Region: CBS_pair_30; cd04643 441771003278 FOG: CBS domain [General function prediction only]; Region: COG0517 441771003279 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 441771003280 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 441771003281 dimer interface [polypeptide binding]; other site 441771003282 phosphorylation site [posttranslational modification] 441771003283 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 441771003284 ATP binding site [chemical binding]; other site 441771003285 Mg2+ binding site [ion binding]; other site 441771003286 G-X-G motif; other site 441771003287 Patatins and Phospholipases; Region: Patatin_and_cPLA2; cl11396 441771003288 nucleophile elbow; other site 441771003289 Mg/Co/Ni transporter MgtE (contains CBS domain) [Inorganic ion transport and metabolism]; Region: MgtE; COG2239 441771003290 MgtE intracellular N domain; Region: MgtE_N; pfam03448 441771003291 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domain in the magnesium transporter, MgtE. MgtE and its homologs are found in eubacteria, archaebacteria, and eukaryota. Members of this family transport Mg2+ or other...; Region: CBS_pair_Mg_transporter; cd04606 441771003292 Divalent cation transporter; Region: MgtE; pfam01769 441771003293 Serine-pyruvate aminotransferase/archaeal aspartate aminotransferase [Amino acid transport and metabolism]; Region: COG0075 441771003294 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 441771003295 catalytic residue [active] 441771003296 Phosphoglycerate dehydrogenase and related dehydrogenases [Amino acid transport and metabolism]; Region: SerA; COG0111 441771003297 Phosphoglycerate dehydrogenase (PGDH) NAD-binding and catalytic domains; Region: PGDH_2; cd05303 441771003298 putative ligand binding site [chemical binding]; other site 441771003299 NAD binding site [chemical binding]; other site 441771003300 dimerization interface [polypeptide binding]; other site 441771003301 catalytic site [active] 441771003302 Protein of unknown function (DUF1015); Region: DUF1015; pfam06245 441771003303 metallo-beta-lactamase/flavodoxin domain-containing protein; Provisional; Region: PRK11921 441771003304 Metallo-beta-lactamase superfamily; Region: Lactamase_B; smart00849 441771003305 NADPH-dependent FMN reductase; Region: FMN_red; cl00438 441771003306 BadF/BadG/BcrA/BcrD ATPase family; Region: BcrAD_BadFG; cl17271 441771003307 Transcriptional regulator/sugar kinase [Transcription / Carbohydrate transport and metabolism]; Region: NagC; COG1940 441771003308 Activator of 2-hydroxyglutaryl-CoA dehydratase (HSP70-class ATPase domain) [Lipid metabolism]; Region: COG1924 441771003309 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3580 441771003310 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3581 441771003311 BCCT family transporter; Region: BCCT; pfam02028 441771003312 Transcriptional regulators [Transcription]; Region: PhnF; COG2188 441771003313 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cl17414 441771003314 DNA-binding site [nucleotide binding]; DNA binding site 441771003315 TrkA-C domain; Region: TrkA_C; pfam02080 441771003316 Flavin Reductases; Region: FlaRed; cl00801 441771003317 Cysteine hydrolases; This family contains amidohydrolases, like CSHase (N-carbamoylsarcosine amidohydrolase), involved in creatine metabolism and nicotinamidase, converting nicotinamide to nicotinic acid and ammonia in the pyridine nucleotide cycle. It...; Region: cysteine_hydrolases; cl00220 441771003318 catalytic triad [active] 441771003319 conserved cis-peptide bond; other site 441771003320 Rhodanese Homology Domain (RHOD); an alpha beta fold domain found duplicated in the rhodanese protein. The cysteine containing enzymatically active version of the domain is also found in the Cdc25 class of protein phosphatases and a variety of proteins...; Region: RHOD; cd00158 441771003321 active site residue [active] 441771003322 Domain of unknown function (DUF4250); Region: DUF4250; pfam14056 441771003323 FOG: TPR repeat [General function prediction only]; Region: NrfG; COG0457 441771003324 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 441771003325 binding surface 441771003326 TPR motif; other site 441771003327 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 441771003328 binding surface 441771003329 TPR motif; other site 441771003330 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 441771003331 active site 441771003332 Protein of unknown function (DUF3867); Region: DUF3867; pfam12983 441771003333 Rhodanese Homology Domain; Region: RHOD; smart00450 441771003334 active site residue [active] 441771003335 Rhodanese-related sulfurtransferase [Inorganic ion transport and metabolism]; Region: SseA; COG2897 441771003336 Thiosulfate sulfurtransferase (TST), N-terminal, inactive domain. TST contains 2 copies of the Rhodanese Homology Domain; this is the 1st repeat, which does not contain the catalytically active Cys residue. The role of the 1st repeat is uncertain, but it...; Region: TST_Repeat_1; cd01448 441771003337 active site residue [active] 441771003338 Thiosulfate sulfurtransferase (TST), C-terminal, catalytic domain. TST contains 2 copies of the Rhodanese Homology Domain; this is the second repeat. Only the second repeat contains the catalytically active Cys residue; Region: TST_Repeat_2; cd01449 441771003339 active site residue [active] 441771003340 Predicted permease, member of the PurR regulon [General function prediction only]; Region: yhhT; COG0628 441771003341 Nucleoside Triphosphate Pyrophosphohydrolase (EC 3.6.1.8) MazG-like domain found in a group of uncharacterized proteins from bacteria and archaea; Region: NTP-PPase_u4; cd11541 441771003342 putative metal binding site [ion binding]; other site 441771003343 Phosphoenolpyruvate carboxykinase (PEPCK), a critical gluconeogenic enzyme, catalyzes the first committed step in the diversion of tricarboxylic acid cycle intermediates toward gluconeogenesis. It catalyzes the reversible decarboxylation and...; Region: PEPCK_HprK; cl00270 441771003344 Phosphoenolpyruvate carboxykinase (PEPCK), a critical gluconeogenic enzyme, catalyzes the first committed step in the diversion of tricarboxylic acid cycle intermediates toward gluconeogenesis. It catalyzes the reversible decarboxylation and...; Region: PEPCK_HprK; cl00270 441771003345 active site 441771003346 metal-binding site [ion binding] 441771003347 nucleotide-binding site [chemical binding]; other site 441771003348 nucleotide-binding site [chemical binding]; other site 441771003349 ABC-type Fe3+ transport system, periplasmic component [Inorganic ion transport and metabolism]; Region: AfuA; COG1840 441771003350 ABC-type Fe3+ transport system, permease component [Inorganic ion transport and metabolism]; Region: ThiP; COG1178 441771003351 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 441771003352 dimer interface [polypeptide binding]; other site 441771003353 conserved gate region; other site 441771003354 putative PBP binding loops; other site 441771003355 ABC-ATPase subunit interface; other site 441771003356 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 441771003357 dimer interface [polypeptide binding]; other site 441771003358 conserved gate region; other site 441771003359 putative PBP binding loops; other site 441771003360 ABC-ATPase subunit interface; other site 441771003361 ABC-type spermidine/putrescine transport systems, ATPase components [Amino acid transport and metabolism]; Region: PotA; COG3842 441771003362 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 441771003363 Walker A/P-loop; other site 441771003364 ATP binding site [chemical binding]; other site 441771003365 Q-loop/lid; other site 441771003366 ABC transporter signature motif; other site 441771003367 Walker B; other site 441771003368 D-loop; other site 441771003369 H-loop/switch region; other site 441771003370 TOBE domain; Region: TOBE_2; pfam08402 441771003371 zinc-ribbon domain; Region: zinc_ribbon_2; pfam13240 441771003372 Double zinc ribbon; Region: DZR; pfam12773 441771003373 zinc-ribbon domain; Region: zinc_ribbon_2; pfam13240 441771003374 Double zinc ribbon; Region: DZR; pfam12773 441771003375 YARHG domain; Region: YARHG; pfam13308 441771003376 30S ribosomal protein S1; Reviewed; Region: rpsA; PRK06676 441771003377 S1_RPS1_repeat_ec1_hs1: Ribosomal protein S1 (RPS1) domain. RPS1 is a component of the small ribosomal subunit thought to be involved in the recognition and binding of mRNA's during translation initiation. The bacterial RPS1 domain architecture...; Region: S1_RPS1_repeat_ec1_hs1; cd05687 441771003378 RNA binding site [nucleotide binding]; other site 441771003379 S1_RPS1_repeat_ec2_hs2: Ribosomal protein S1 (RPS1) domain. RPS1 is a component of the small ribosomal subunit thought to be involved in the recognition and binding of mRNA's during translation initiation. The bacterial RPS1 domain architecture...; Region: S1_RPS1_repeat_ec2_hs2; cd04465 441771003380 RNA binding site [nucleotide binding]; other site 441771003381 S1_RPS1_repeat_ec3: Ribosomal protein S1 (RPS1) domain. RPS1 is a component of the small ribosomal subunit thought to be involved in the recognition and binding of mRNA's during translation initiation. The bacterial RPS1 domain architecture consists...; Region: S1_RPS1_repeat_ec3; cd05688 441771003382 RNA binding site [nucleotide binding]; other site 441771003383 S1_like: Ribosomal protein S1-like RNA-binding domain. Found in a wide variety of RNA-associated proteins. Originally identified in S1 ribosomal protein. This superfamily also contains the Cold Shock Domain (CSD), which is a homolog of the S1 domain; Region: S1_like; cl09927 441771003384 RNA binding site [nucleotide binding]; other site 441771003385 4-hydroxybenzoyl-CoA thioesterase (4HBT). Catalyzes the final step in the 4-chlorobenzoate degradation pathway in which 4-chlorobenzoate is converted to 4-hydroxybenzoate in certain soil-dwelling bacteria. 4HBT forms a homotetramer with four active sites; Region: 4HBT; cd00586 441771003386 active site 441771003387 Histidine Utilizing Protein, the hut operon positive regulatory protein; Region: HutP; cd11640 441771003388 hexamer interface [polypeptide binding]; other site 441771003389 RNA binding site [nucleotide binding]; other site 441771003390 Histidine-zinc binding site [chemical binding]; other site 441771003391 Type I periplasmic ligand-binding domain of uncharacterized ABC-type transport systems that are predicted to be involved in the uptake of amino acids, peptides, or inorganic ions; Region: PBP1_ABC_uncharacterized_transporter; cd06325 441771003392 Periplasmic binding protein domain; Region: Peripla_BP_4; pfam13407 441771003393 zinc binding site [ion binding]; other site 441771003394 putative ligand binding site [chemical binding]; other site 441771003395 Transmembrane subunit (TM) of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which are involved in the uptake of branched-chain amino acids (AAs), as well as TMs of transporters involved in the uptake of...; Region: TM_PBP1_branched-chain-AA_like; cd06574 441771003396 TM-ABC transporter signature motif; other site 441771003397 ABC-type uncharacterized transport system, ATPase component [General function prediction only]; Region: PhnK; COG1101 441771003398 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 441771003399 Walker A/P-loop; other site 441771003400 ATP binding site [chemical binding]; other site 441771003401 Q-loop/lid; other site 441771003402 ABC transporter signature motif; other site 441771003403 Walker B; other site 441771003404 D-loop; other site 441771003405 H-loop/switch region; other site 441771003406 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 441771003407 pyridoxal 5'-phosphate binding site [chemical binding]; other site 441771003408 homodimer interface [polypeptide binding]; other site 441771003409 catalytic residue [active] 441771003410 Permeases of the drug/metabolite transporter (DMT) superfamily [Carbohydrate transport and metabolism / Amino acid transport and metabolism / General function prediction only]; Region: RhaT; COG0697 441771003411 EamA-like transporter family; Region: EamA; pfam00892 441771003412 EamA-like transporter family; Region: EamA; pfam00892 441771003413 putative kinase; Provisional; Region: PRK09954 441771003414 Winged helix-turn-helix DNA-binding; Region: HTH_24; pfam13412 441771003415 YeiC-like sugar kinase. Found in eukaryotes and bacteria, YeiC-like kinase is part of the ribokinase/pfkB sugar kinase superfamily. Its oligomerization state is unknown at this time; Region: YeiC_kinase_like; cd01941 441771003416 substrate binding site [chemical binding]; other site 441771003417 ATP binding site [chemical binding]; other site 441771003418 Indigoidine synthase A like protein; Region: Indigoidine_A; pfam04227 441771003419 2-dehydropantoate 2-reductase; Reviewed; Region: PRK06522 441771003420 Ketopantoate reductase PanE/ApbA; Region: ApbA; pfam02558 441771003421 Ketopantoate reductase PanE/ApbA C terminal; Region: ApbA_C; pfam08546 441771003422 Formiminotransferase-cyclodeaminase; Region: FTCD_C; pfam04961 441771003423 5,10-methylene-tetrahydrofolate dehydrogenase/Methenyl tetrahydrofolate cyclohydrolase [Coenzyme metabolism]; Region: FolD; COG0190 441771003424 Tetrahydrofolate dehydrogenase/cyclohydrolase, catalytic domain; Region: THF_DHG_CYH; pfam00763 441771003425 NADP binding domain of methylene-tetrahydrofolate dehydrogenase/cyclohydrolase; Region: NAD_bind_m-THF_DH_Cyclohyd; cd01080 441771003426 homodimer interface [polypeptide binding]; other site 441771003427 NADP binding site [chemical binding]; other site 441771003428 substrate binding site [chemical binding]; other site 441771003429 haloacid dehalogenase-like hydrolase; Region: Hydrolase_3; pfam08282 441771003430 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 441771003431 active site 441771003432 motif I; other site 441771003433 motif II; other site 441771003434 haloacid dehalogenase-like hydrolase; Region: HAD; cl19137 441771003435 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 441771003436 Coenzyme A binding pocket [chemical binding]; other site 441771003437 Predicted divalent heavy-metal cations transporter [Inorganic ion transport and metabolism]; Region: COG0428 441771003438 Predicted transcriptional regulator [Transcription]; Region: COG1959 441771003439 Rrf2 family protein; Region: rrf2_super; TIGR00738 441771003440 CBS_like: This subgroup includes Cystathionine beta-synthase (CBS) and Cysteine synthase. CBS is a unique heme-containing enzyme that catalyzes a pyridoxal 5'-phosphate (PLP)-dependent condensation of serine and homocysteine to give cystathionine; Region: CBS_like; cd01561 441771003441 dimer interface [polypeptide binding]; other site 441771003442 pyridoxal 5'-phosphate binding site [chemical binding]; other site 441771003443 catalytic residue [active] 441771003444 ABC-type amino acid transport system, permease component [Amino acid transport and metabolism]; Region: HisM; COG0765 441771003445 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 441771003446 dimer interface [polypeptide binding]; other site 441771003447 conserved gate region; other site 441771003448 putative PBP binding loops; other site 441771003449 ABC-ATPase subunit interface; other site 441771003450 cystine transporter subunit; Provisional; Region: PRK11260 441771003451 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 441771003452 substrate binding pocket [chemical binding]; other site 441771003453 membrane-bound complex binding site; other site 441771003454 hinge residues; other site 441771003455 Cysteine sulfinate desulfinase/cysteine desulfurase and related enzymes [Amino acid transport and metabolism]; Region: NifS; COG1104 441771003456 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 441771003457 catalytic residue [active] 441771003458 ATP-utilizing enzymes of the PP-loop superfamily [General function prediction only]; Region: COG1606 441771003459 This is a subfamily of Adenine nucleotide alpha hydrolases superfamily. Adenine nucleotide alpha hydrolases superfamily includes N type ATP PPases and ATP sulphurylases. It forms a apha/beta/apha fold which binds to Adenosine group. This subfamily; Region: Alpha_ANH_like_I; cd01990 441771003460 Ligand Binding Site [chemical binding]; other site 441771003461 Predicted tRNA(5-methylaminomethyl-2-thiouridylate) methyltransferase, contains the PP-loop ATPase domain [Translation, ribosomal structure and biogenesis]; Region: TrmU; COG0482 441771003462 tRNA methyl transferase. This family represents tRNA(5-methylaminomethyl-2-thiouridine)-methyltransferase which is involved in the biosynthesis of the modified nucleoside 5-methylaminomethyl-2-thiouridine present in the wobble position of some tRNAs; Region: tRNA_Me_trans; cd01998 441771003463 Ligand Binding Site [chemical binding]; other site 441771003464 Response regulator of the LytR/AlgR family [Transcription / Signal transduction mechanisms]; Region: LytT; COG3279 441771003465 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 441771003466 active site 441771003467 phosphorylation site [posttranslational modification] 441771003468 intermolecular recognition site; other site 441771003469 LytTr DNA-binding domain; Region: LytTR; pfam04397 441771003470 Predicted signal transduction protein with a C-terminal ATPase domain [Signal transduction mechanisms]; Region: COG2972 441771003471 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 441771003472 ATP binding site [chemical binding]; other site 441771003473 Mg2+ binding site [ion binding]; other site 441771003474 G-X-G motif; other site 441771003475 ABC-type multidrug transport system, ATPase component [Defense mechanisms]; Region: CcmA; COG1131 441771003476 ATP-binding cassette domain of the bacitracin-resistance transporter; Region: ABC_BcrA_bacitracin_resist; cd03268 441771003477 Walker A/P-loop; other site 441771003478 ATP binding site [chemical binding]; other site 441771003479 Q-loop/lid; other site 441771003480 ABC transporter signature motif; other site 441771003481 Walker B; other site 441771003482 D-loop; other site 441771003483 H-loop/switch region; other site 441771003484 ABC-2 family transporter protein; Region: ABC2_membrane_2; pfam12679 441771003485 Membrane domain of glycerophosphoryl diester phosphodiesterase; Region: GPDPase_memb; pfam10110 441771003486 Glycerophosphodiester phosphodiesterase domain of uncharacterized bacterial glycerophosphodiester phosphodiesterases; Region: GDPD_memb_like; cd08579 441771003487 Glycerophosphoryl diester phosphodiesterase [Energy production and conversion]; Region: UgpQ; COG0584 441771003488 putative active site [active] 441771003489 catalytic site [active] 441771003490 putative metal binding site [ion binding]; other site 441771003491 Domain of unknown function (DUF3787); Region: DUF3787; pfam12655 441771003492 pyruvate:ferredoxin (flavodoxin) oxidoreductase, homodimeric; Region: pyruv_ox_red; TIGR02176 441771003493 Pyrimidine (PYR) binding domain of pyruvate ferredoxin oxidoreductase (PFOR), indolepyruvate ferredoxin oxidoreductase alpha subunit (IOR-alpha), and related proteins; Region: TPP_PYR_PFOR_IOR-alpha_like; cd07034 441771003494 dimer interface [polypeptide binding]; other site 441771003495 PYR/PP interface [polypeptide binding]; other site 441771003496 TPP binding site [chemical binding]; other site 441771003497 substrate binding site [chemical binding]; other site 441771003498 Pyruvate:ferredoxin oxidoreductase and related 2-oxoacid:ferredoxin oxidoreductases, gamma subunit [Energy production and conversion]; Region: PorG; COG1014 441771003499 Domain of unknown function; Region: EKR; pfam10371 441771003500 4Fe-4S dicluster domain; Region: Fer4_8; pfam13183 441771003501 Thiamine pyrophosphate (TPP family), PFOR_PNO subfamily, TPP-binding module; composed of proteins similar to the single subunit pyruvate ferredoxin oxidoreductase (PFOR) of Desulfovibrio Africanus, present in bacteria and amitochondriate eukaryotes. This...; Region: TPP_PFOR_PNO; cd03377 441771003502 TPP-binding site [chemical binding]; other site 441771003503 dimer interface [polypeptide binding]; other site 441771003504 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 441771003505 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 441771003506 Kef-type K+ transport systems, membrane components [Inorganic ion transport and metabolism]; Region: KefB; cl10482 441771003507 hypothetical protein; Validated; Region: PRK00029 441771003508 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450 441771003509 Monoamine oxidase [Amino acid transport and metabolism]; Region: COG1231 441771003510 AraC-like ligand binding domain; Region: AraC_binding; pfam02311 441771003511 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 441771003512 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 441771003513 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 441771003514 putative symporter YagG; Provisional; Region: PRK09669; cl15392 441771003515 putative symporter YagG; Provisional; Region: PRK09669; cl15392 441771003516 O-Glycosyl hydrolase family 30; Region: Glyco_hydro_30; pfam02055 441771003517 Transcriptional regulator/sugar kinase [Transcription / Carbohydrate transport and metabolism]; Region: NagC; COG1940 441771003518 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cd00012 441771003519 nucleotide binding site [chemical binding]; other site 441771003520 Glycosyl hydrolase family 1; Region: Glyco_hydro_1; pfam00232 441771003521 Beta-glucosidase/6-phospho-beta-glucosidase/beta- galactosidase [Carbohydrate transport and metabolism]; Region: BglB; COG2723 441771003522 Domain of unknown function (DUF4434); Region: DUF4434; cl03185 441771003523 Beta-amylase, C-terminal CBM20 (carbohydrate-binding module, family 20) domain. Beta-amylase has, in addition to its C-terminal CBM20 domain, an N-terminal catalytic domain belonging to glycosyl hydrolase family 14, which hydrolyzes the alpha-1; Region: CBM20_beta_amylase; cd05809 441771003524 starch-binding site 2 [chemical binding]; other site 441771003525 starch-binding site 1 [chemical binding]; other site 441771003526 tyrosyl-tRNA synthetase; Provisional; Region: PRK13354 441771003527 catalytic core domain of tyrosinyl-tRNA synthetase; Region: TyrRS_core; cd00805 441771003528 active site 441771003529 HIGH motif; other site 441771003530 dimer interface [polypeptide binding]; other site 441771003531 KMSKS motif; other site 441771003532 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 441771003533 RNA binding surface [nucleotide binding]; other site 441771003534 Predicted transcriptional regulators [Transcription]; Region: COG1725 441771003535 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 441771003536 DNA-binding site [nucleotide binding]; DNA binding site 441771003537 Terpene synthase, N-terminal domain; Region: Terpene_synth; pfam01397 441771003538 ABC-type multidrug transport system, ATPase component [Defense mechanisms]; Region: CcmA; COG1131 441771003539 ATP-binding cassette domain of the drug resistance transporter and related proteins, subfamily A; Region: ABC_DR_subfamily_A; cd03230 441771003540 Walker A/P-loop; other site 441771003541 ATP binding site [chemical binding]; other site 441771003542 Q-loop/lid; other site 441771003543 ABC transporter signature motif; other site 441771003544 Walker B; other site 441771003545 D-loop; other site 441771003546 H-loop/switch region; other site 441771003547 RecF/RecN/SMC N terminal domain; Region: SMC_N; pfam02463 441771003548 Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118 441771003549 Predicted glycosyl hydrolase [General function prediction only]; Region: COG3858 441771003550 Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118 441771003551 Bacterial SH3 domain; Region: SH3_3; pfam08239 441771003552 Cortical fragment-lytic enzyme (CFLE) is a peptidoglycan hydrolase involved in bacterial endospore germination. CFLE is expressed as an inactive preprotein (called SleB) in the forespore compartment of sporulating cells. SleB translocates across the...; Region: GH18_CFLE_spore_hydrolase; cd02874 441771003553 active site 441771003554 PAS domain S-box; Region: sensory_box; TIGR00229 441771003555 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 441771003556 putative active site [active] 441771003557 heme pocket [chemical binding]; other site 441771003558 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 441771003559 metal binding site [ion binding]; metal-binding site 441771003560 active site 441771003561 I-site; other site 441771003562 L-serine dehydratase, iron-sulfur-dependent, beta subunit; Region: sda_beta; TIGR00719 441771003563 Serine dehydratase beta chain; Region: SDH_beta; pfam03315 441771003564 C-terminal ACT domain of the L-serine dehydratase (LSD), iron-sulfur-dependent, beta subunit; Region: ACT_LSD; cd04903 441771003565 putative L-serine binding site [chemical binding]; other site 441771003566 Serine dehydratase alpha chain; Region: SDH_alpha; cl12120 441771003567 L-serine deaminase [Amino acid transport and metabolism]; Region: SdaA; COG1760 441771003568 Uncharacterized conserved protein [Function unknown]; Region: COG5663 441771003569 haloacid dehalogenase-like hydrolase; Region: Hydrolase; pfam00702 441771003570 renal dipeptidase (rDP), best studied in mammals and also called membrane or microsomal dipeptidase, is a membrane-bound glycoprotein hydrolyzing dipeptides and is involved in hydrolytic metabolism of penem and carbapenem beta-lactam antibiotics; Region: rDP_like; cd01301 441771003571 active site 441771003572 dimer interface [polypeptide binding]; other site 441771003573 Yip1 domain; Region: Yip1; pfam04893 441771003574 ABC-type transport system, involved in lipoprotein release, permease component [Cell envelope biogenesis, outer membrane]; Region: LolE; COG4591 441771003575 MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704 441771003576 FtsX-like permease family; Region: FtsX; pfam02687 441771003577 S-layer domain [Cell envelope biogenesis, outer membrane]; Region: COG1361 441771003578 ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136 441771003579 ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255 441771003580 Walker A/P-loop; other site 441771003581 ATP binding site [chemical binding]; other site 441771003582 Q-loop/lid; other site 441771003583 ABC transporter signature motif; other site 441771003584 Walker B; other site 441771003585 D-loop; other site 441771003586 H-loop/switch region; other site 441771003587 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppC; COG1173 441771003588 N-terminal TM domain of oligopeptide transport permease C; Region: OppC_N; pfam12911 441771003589 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 441771003590 dimer interface [polypeptide binding]; other site 441771003591 conserved gate region; other site 441771003592 putative PBP binding loops; other site 441771003593 ABC-ATPase subunit interface; other site 441771003594 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppB; COG0601 441771003595 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 441771003596 dimer interface [polypeptide binding]; other site 441771003597 conserved gate region; other site 441771003598 putative PBP binding loops; other site 441771003599 ABC-ATPase subunit interface; other site 441771003600 ABC-type dipeptide transport system, periplasmic component [Amino acid transport and metabolism]; Region: DdpA; COG0747 441771003601 The substrate-binding domain of an ABC-type nickel/oligopeptide-like import system contains the type 2 periplasmic binding fold; Region: PBP2_NikA_DppA_OppA_like; cd00995 441771003602 Spore coat associated protein JA (CotJA); Region: CotJA; pfam11007 441771003603 CotJB protein; Region: CotJB; pfam12652 441771003604 Manganese catalase, ferritin-like diiron-binding domain; Region: Mn_catalase; cd01051 441771003605 dimanganese center [ion binding]; other site 441771003606 Exopolysaccharide biosynthesis protein related to N-acetylglucosamine-1-phosphodiester alpha-N-acetylglucosaminidase [Carbohydrate transport and metabolism]; Region: EpsL; COG4632 441771003607 Predicted periplasmic protein (DUF2233); Region: DUF2233; pfam09992 441771003608 Tubby C 2; Region: Tub_2; cl02043 441771003609 Trimeric dUTP diphosphatases; Region: trimeric_dUTPase; cd07557 441771003610 trimer interface [polypeptide binding]; other site 441771003611 active site 441771003612 small acid-soluble spore protein, H-type; Region: SASP_H; TIGR02861 441771003613 Spo0E like sporulation regulatory protein; Region: SpoOE-like; pfam09388 441771003614 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 441771003615 non-specific DNA binding site [nucleotide binding]; other site 441771003616 salt bridge; other site 441771003617 sequence-specific DNA binding site [nucleotide binding]; other site 441771003618 Cupin domain; Region: Cupin_2; pfam07883 441771003619 Phosphotransferase system, EIIC; Region: PTS_EIIC_2; pfam13303 441771003620 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 441771003621 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 441771003622 Na+/alanine symporter [Amino acid transport and metabolism]; Region: AlsT; COG1115 441771003623 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 441771003624 non-specific DNA binding site [nucleotide binding]; other site 441771003625 salt bridge; other site 441771003626 sequence-specific DNA binding site [nucleotide binding]; other site 441771003627 Helix-turn-helix domain; Region: HTH_17; pfam12728 441771003628 NrdH-redoxin (NrdH) family; NrdH is a small monomeric protein with a conserved redox active CXXC motif within a TRX fold, characterized by a glutaredoxin (GRX)-like sequence and TRX-like activity profile. In vitro, it displays protein disulfide reductase...; Region: NrdH; cd02976 441771003629 catalytic residues [active] 441771003630 NADP+-dependent non-phosphorylating glyceraldehyde 3-phosphate dehydrogenase and ALDH family 11; Region: ALDH_F11_NP-GAPDH; cd07082 441771003631 tetrameric interface [polypeptide binding]; other site 441771003632 activator binding site; other site 441771003633 NADP binding site [chemical binding]; other site 441771003634 substrate binding site [chemical binding]; other site 441771003635 catalytic residues [active] 441771003636 thioredoxin-disulfide reductase; Region: TRX_reduct; TIGR01292 441771003637 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl19134 441771003638 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl19134 441771003639 Glycine/sarcosine/betaine reductase component B subunits; Region: Gly_reductase; pfam09338 441771003640 Glycine/sarcosine/betaine reductase selenoprotein B (GRDB); Region: GRDB; cl19416 441771003641 thioredoxin-disulfide reductase; Region: TRX_reduct; TIGR01292 441771003642 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl19134 441771003643 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 441771003644 TRX family; composed of two groups: Group I, which includes proteins that exclusively encode a TRX domain; and Group II, which are composed of fusion proteins of TRX and additional domains. Group I TRX is a small ancient protein that alter the redox...; Region: TRX_family; cd02947 441771003645 catalytic residues [active] 441771003646 "initiating" condensing enzymes are a subclass of decarboxylating condensing enzymes, including beta-ketoacyl [ACP] synthase, type III and polyketide synthases, type III, which include chalcone synthase and related enzymes. They are...; Region: init_cond_enzymes; cd00827 441771003647 dimer interface [polypeptide binding]; other site 441771003648 active site 441771003649 Fatty acid synthesis protein; Region: FA_synthesis; cl17261 441771003650 Alkyladenine DNA glycosylase catalyzes the first step in base excision repair; Region: AAG; cd00540 441771003651 active site 441771003652 DNA binding site [nucleotide binding] 441771003653 Eco57I restriction-modification methylase; Region: Eco57I; pfam07669 441771003654 TaqI-like C-terminal specificity domain; Region: TaqI_C; pfam12950 441771003655 methylthioribose kinase; Reviewed; Region: mtnK; PRK09550 441771003656 methylthioribose-1-phosphate isomerase; Reviewed; Region: mtnA; PRK05720 441771003657 glutamine ABC transporter ATP-binding protein; Reviewed; Region: glnQ; PRK09493 441771003658 Class II Aldolase and Adducin N-terminal domain; Region: Aldolase_II; pfam00596 441771003659 intersubunit interface [polypeptide binding]; other site 441771003660 active site 441771003661 Zn2+ binding site [ion binding]; other site 441771003662 Transcriptional regulators of sugar metabolism [Transcription / Carbohydrate transport and metabolism]; Region: GlpR; COG1349 441771003663 DeoR-like helix-turn-helix domain; Region: HTH_DeoR; cl17531 441771003664 DeoR C terminal sensor domain; Region: DeoRC; pfam00455 441771003665 Protein of unknown function (DUF1049); Region: DUF1049; cl01539 441771003666 Predicted Co/Zn/Cd cation transporters [Inorganic ion transport and metabolism]; Region: MMT1; COG0053 441771003667 Predicted membrane protein [Function unknown]; Region: COG2323 441771003668 Domain of unknown function (DUF4363); Region: DUF4363; pfam14276 441771003669 Sporulation protein YtrH; Region: Spore_YtrH; pfam14034 441771003670 Protein of unknown function (DUF3267); Region: DUF3267; pfam11667 441771003671 A short protein domain of unknown function; Region: IDEAL; smart00914 441771003672 PQ loop repeat; Region: PQ-loop; pfam04193 441771003673 xanthine dehydrogenase subunit XdhA; Provisional; Region: PRK09970 441771003674 Aldehyde oxidase and xanthine dehydrogenase, a/b hammerhead domain; Region: Ald_Xan_dh_C; smart01008 441771003675 Molybdopterin-binding domain of aldehyde dehydrogenase; Region: Ald_Xan_dh_C2; pfam02738 441771003676 xanthine dehydrogenase subunit XdhB; Provisional; Region: PRK09971 441771003677 FAD binding domain in molybdopterin dehydrogenase; Region: FAD_binding_5; pfam00941 441771003678 CO dehydrogenase flavoprotein C-terminal domain; Region: CO_deh_flav_C; smart01092 441771003679 Aerobic-type carbon monoxide dehydrogenase, small subunit CoxS/CutS homologs [Energy production and conversion]; Region: CoxS; COG2080 441771003680 2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207 441771003681 catalytic loop [active] 441771003682 2Fe-2S iron-sulfur cluster binding domain; Region: Fer2_3; pfam13085 441771003683 iron binding site [ion binding]; other site 441771003684 [2Fe-2S] binding domain; Region: Fer2_2; pfam01799 441771003685 Nucleoside deaminases include adenosine, guanine and cytosine deaminases. These enzymes are Zn dependent and catalyze the deamination of nucleosides. The zinc ion in the active site plays a central role in the proposed catalytic mechanism, activating a...; Region: nucleoside_deaminase; cd01285 441771003686 nucleoside/Zn binding site; other site 441771003687 dimer interface [polypeptide binding]; other site 441771003688 catalytic motif [active] 441771003689 DNA topoisomerase III; Provisional; Region: PRK07726 441771003690 TOPRIM_TopoIA_TopoIII: The topoisomerase-primase (TORPIM) domain found in members of the type IA family of DNA topoisomerases (Topo IA) similar to topoisomerase III. Type IA DNA topoisomerases remove (relax) negative supercoils in the DNA by: cleaving...; Region: TOPRIM_TopoIA_TopoIII; cd03362 441771003691 active site 441771003692 putative interdomain interaction site [polypeptide binding]; other site 441771003693 putative metal-binding site [ion binding]; other site 441771003694 putative nucleotide binding site [chemical binding]; other site 441771003695 DNA Topoisomerase, subtype IA; DNA-binding, ATP-binding and catalytic domain of bacterial DNA topoisomerases I and III, and eukaryotic DNA topoisomerase III and eubacterial and archael reverse gyrases. Topoisomerases clevage single or double stranded DNA...; Region: TOP1Ac; cd00186 441771003696 domain I; other site 441771003697 DNA binding groove [nucleotide binding] 441771003698 phosphate binding site [ion binding]; other site 441771003699 domain II; other site 441771003700 domain III; other site 441771003701 nucleotide binding site [chemical binding]; other site 441771003702 catalytic site [active] 441771003703 domain IV; other site 441771003704 Zn-finger domain associated with topoisomerase type I [DNA replication, recombination, and repair]; Region: TopA; COG0551 441771003705 Predicted membrane protein [Function unknown]; Region: COG1971 441771003706 Domain of unknown function DUF; Region: DUF204; pfam02659 441771003707 Domain of unknown function DUF; Region: DUF204; pfam02659 441771003708 Uncharacterized conserved protein (DUF2164); Region: DUF2164; pfam09932 441771003709 Transaldolase-like fructose-6-phosphate aldolases (FSA) found in bacteria and archaea; Region: Transaldolase_FSA; cd00956 441771003710 active site 441771003711 intersubunit interactions; other site 441771003712 catalytic residue [active] 441771003713 mRNA degradation ribonucleases J1/J2 (metallo-beta-lactamase superfamily) [Translation, ribosomal structure and biogenesis; Replication, recombination and repair]; Region: COG0595 441771003714 Metallo-beta-lactamase superfamily; Region: Lactamase_B; smart00849 441771003715 RNA-metabolizing metallo-beta-lactamase; Region: RMMBL; pfam07521 441771003716 Na+/alanine symporter [Amino acid transport and metabolism]; Region: AlsT; COG1115 441771003717 Class III nucleotidyl cyclases; Region: Nucleotidyl_cyc_III; cl11967 441771003718 nucleotidyl binding site; other site 441771003719 metal binding site [ion binding]; metal-binding site 441771003720 Putative NodB-like catalytic domain of uncharacterized proteins found in bacteria; Region: CE4_COG5298; cd10923 441771003721 NodB motif; other site 441771003722 putative active site [active] 441771003723 putative catalytic site [active] 441771003724 putative Zn binding site [ion binding]; other site 441771003725 Glycosyltransferases, probably involved in cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: COG1215 441771003726 CESA_like is the cellulose synthase superfamily; Region: CESA_like; cd06423 441771003727 DXD motif; other site 441771003728 Bacterial cellulose synthase subunit; Region: BcsB; pfam03170 441771003729 Probable zinc-binding domain; Region: zf-trcl; pfam13451 441771003730 Protein of unknown function (DUF2837); Region: DUF2837; pfam10997 441771003731 Uncharacterized family 2; belongs to a superfamily containing transcriptional regulators CsoR (copper-sensitive operon repressor), RcnR, and FrmR, and related domains; this family was previously known as part of DUF156; Region: CsoR-like_DUF156_2; cd10159 441771003732 putative homodimer interface [polypeptide binding]; other site 441771003733 putative homotetramer interface [polypeptide binding]; other site 441771003734 putative allosteric switch controlling residues; other site 441771003735 putative metal binding site [ion binding]; other site 441771003736 putative homodimer-homodimer interface [polypeptide binding]; other site 441771003737 Heavy-metal-associated domain (HMA) is a conserved domain of approximately 30 amino acid residues found in a number of proteins that transport or detoxify heavy metals, for example, the CPx-type heavy metal ATPases and copper chaperones. HMA domain...; Region: HMA; cd00371 441771003738 metal-binding site [ion binding] 441771003739 Cation transport ATPase [Inorganic ion transport and metabolism]; Region: ZntA; COG2217 441771003740 Heavy-metal-associated domain (HMA) is a conserved domain of approximately 30 amino acid residues found in a number of proteins that transport or detoxify heavy metals, for example, the CPx-type heavy metal ATPases and copper chaperones. HMA domain...; Region: HMA; cd00371 441771003741 metal-binding site [ion binding] 441771003742 E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122 441771003743 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 441771003744 motif II; other site 441771003745 Heavy-metal-associated domain (HMA) is a conserved domain of approximately 30 amino acid residues found in a number of proteins that transport or detoxify heavy metals, for example, the CPx-type heavy metal ATPases and copper chaperones. HMA domain...; Region: HMA; cd00371 441771003746 metal-binding site [ion binding] 441771003747 Cation transport ATPase [Inorganic ion transport and metabolism]; Region: MgtA; COG0474 441771003748 E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122 441771003749 Putative hydrolase of sodium-potassium ATPase alpha subunit; Region: Hydrolase_like2; pfam13246 441771003750 haloacid dehalogenase-like hydrolase; Region: HAD; cl19137 441771003751 Cation transporting ATPase, C-terminus; Region: Cation_ATPase_C; pfam00689 441771003752 ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132 441771003753 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 441771003754 ATP-binding cassette domain of the bacterial lipid flippase and related proteins, subfamily C; Region: ABCC_MsbA; cd03251 441771003755 Walker A/P-loop; other site 441771003756 ATP binding site [chemical binding]; other site 441771003757 Q-loop/lid; other site 441771003758 ABC transporter signature motif; other site 441771003759 Walker B; other site 441771003760 D-loop; other site 441771003761 H-loop/switch region; other site 441771003762 CAAX protease self-immunity; Region: Abi; pfam02517 441771003763 This uncharacterized conserved protein belongs to a family of iron-molybdenum cluster-binding proteins that includes NifX, NifB, and NifY, all of which are involved in the synthesis of an iron-molybdenum cofactor (FeMo-co) that binds the active site of...; Region: MTH1175; cd00851 441771003764 EDD domain protein, DegV family; Region: DegV; TIGR00762 441771003765 Pyridoxamine 5'-phosphate oxidase; Region: Pyridox_ox_2; cl17869 441771003766 Diadenosine tetraphosphate (Ap4A) hydrolase and other HIT family hydrolases [Nucleotide transport and metabolism / Carbohydrate transport and metabolism / General function prediction only]; Region: Hit; COG0537 441771003767 nucleotide binding site/active site [active] 441771003768 HIT family signature motif; other site 441771003769 catalytic residue [active] 441771003770 Membrane protein of unknown function; Region: DUF360; pfam04020 441771003771 Type II secretory pathway, prepilin signal peptidase PulO and related peptidases [Cell motility and secretion / Posttranslational modification, protein turnover, chaperones / Intracellular trafficking and secretion]; Region: PulO; COG1989 441771003772 Bacterial Peptidase A24 N-terminal domain; Region: DiS_P_DiS; pfam06750 441771003773 Type IV leader peptidase family; Region: Peptidase_A24; pfam01478 441771003774 YibE/F-like protein; Region: YibE_F; pfam07907 441771003775 Trk-type K+ transport systems, membrane components [Inorganic ion transport and metabolism]; Region: TrkG; COG0168 441771003776 Cation transport protein; Region: TrkH; cl17365 441771003777 Superfamily I DNA and RNA helicases [DNA replication, recombination, and repair]; Region: UvrD; COG0210 441771003778 Part of AAA domain; Region: AAA_19; pfam13245 441771003779 DEDDh 3'-5' exonuclease domain family; Region: DEDDh; cd06127 441771003780 active site 441771003781 catalytic site [active] 441771003782 substrate binding site [chemical binding]; other site 441771003783 UvrD-like helicase C-terminal domain; Region: UvrD_C_2; pfam13538 441771003784 Protein of unknown function (DUF1648); Region: DUF1648; cl19856 441771003785 Predicted transcriptional regulators [Transcription]; Region: COG1725 441771003786 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 441771003787 DNA-binding site [nucleotide binding]; DNA binding site 441771003788 Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118 441771003789 Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118 441771003790 Cell Wall Hydrolase; Region: Hydrolase_2; pfam07486 441771003791 Rubrerythrin [Energy production and conversion]; Region: COG1592 441771003792 Rubrerythrin, ferritin-like diiron-binding domain; Region: Rubrerythrin; cd01041 441771003793 binuclear metal center [ion binding]; other site 441771003794 Rubredoxin, Small Modular nonheme iron binding domain containing a [Fe(SCys)4] center, present in rubrerythrin and nigerythrin and detected either N- or C-terminal to such proteins as flavin reductase, NAD(P)H-nitrite reductase, and...; Region: rubredoxin_SM; cd00729 441771003795 iron binding site [ion binding]; other site 441771003796 Putative cell wall binding repeat 2; Region: CW_binding_2; pfam04122 441771003797 Putative cell wall binding repeat 2; Region: CW_binding_2; pfam04122 441771003798 Putative cell wall binding repeat 2; Region: CW_binding_2; pfam04122 441771003799 Phosphotransferase system IIC components, glucose/maltose/N-acetylglucosamine-specific [Carbohydrate transport and metabolism]; Region: PtsG; COG1263 441771003800 PTS system, glucose-specific IIBC component; Region: PTS-II-BC-glcB; TIGR02002 441771003801 PTS_IIB, PTS system, glucose/sucrose specific IIB subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIB_glc; cd00212 441771003802 active site turn [active] 441771003803 phosphorylation site [posttranslational modification] 441771003804 Phosphotransferase system IIA components [Carbohydrate transport and metabolism]; Region: NagE; COG2190 441771003805 HPr interaction site; other site 441771003806 glycerol kinase (GK) interaction site [polypeptide binding]; other site 441771003807 active site 441771003808 phosphorylation site [posttranslational modification] 441771003809 Cis (Z)-Isoprenyl Diphosphate Synthases; Region: Cis_IPPS; cd00475 441771003810 active site 441771003811 dimer interface [polypeptide binding]; other site 441771003812 Predicted transcriptional regulator [Transcription]; Region: COG1959 441771003813 Rrf2 family protein; Region: rrf2_super; TIGR00738 441771003814 The HCP family of iron-sulfur proteins includes hybrid cluster protein (HCP), acetyl-CoA synthase (ACS), and carbon monoxide dehydrogenase (CODH), all of which contain [Fe4-S4] metal clusters at their active sites. These proteins have a conserved...; Region: HCP_like; cl19102 441771003815 ACS interaction site; other site 441771003816 CODH interaction site; other site 441771003817 metal cluster binding site [ion binding]; other site 441771003818 4Fe-4S dicluster domain; Region: Fer4_11; pfam13247 441771003819 4Fe-4S dicluster domain; Region: Fer4_9; pfam13187 441771003820 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox_2; pfam07992 441771003821 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 441771003822 Carboxylate/Amino Acid/Amine Transporter; Region: 2A78; TIGR00950 441771003823 EamA-like transporter family; Region: EamA; pfam00892 441771003824 cAMP-binding proteins - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases [Signal transduction mechanisms]; Region: Crp; COG0664 441771003825 effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038 441771003826 ligand binding site [chemical binding]; other site 441771003827 flexible hinge region; other site 441771003828 Crp-like helix-turn-helix domain; Region: HTH_Crp_2; pfam13545 441771003829 putative switch regulator; other site 441771003830 non-specific DNA interactions [nucleotide binding]; other site 441771003831 DNA binding site [nucleotide binding] 441771003832 sequence specific DNA binding site [nucleotide binding]; other site 441771003833 putative cAMP binding site [chemical binding]; other site 441771003834 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 441771003835 Major Facilitator Superfamily; Region: MFS_1; pfam07690 441771003836 putative substrate translocation pore; other site 441771003837 ABC-type Fe3+-hydroxamate transport system, periplasmic component [Inorganic ion transport and metabolism]; Region: FepB; COG0614 441771003838 Periplasmic binding protein YvrC. These proteins are predicted to function as initial receptors in ABC transport of metal ions in eubacteria and archaea. They belong to the TroA superfamily of periplasmic metal binding proteins that share a distinct...; Region: YvrC; cd01143 441771003839 putative binding site residues; other site 441771003840 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550 441771003841 ABC-ATPase subunit interface; other site 441771003842 dimer interface [polypeptide binding]; other site 441771003843 putative PBP binding regions; other site 441771003844 ABC-type cobalamin/Fe3+-siderophores transport systems, ATPase components [Inorganic ion transport and metabolism / Coenzyme metabolism]; Region: FepC; COG1120 441771003845 ATP-binding component of iron-siderophores, vitamin B12 and hemin transporters and related proteins; Region: ABC_Iron-Siderophores_B12_Hemin; cd03214 441771003846 Walker A/P-loop; other site 441771003847 ATP binding site [chemical binding]; other site 441771003848 Q-loop/lid; other site 441771003849 ABC transporter signature motif; other site 441771003850 Walker B; other site 441771003851 D-loop; other site 441771003852 H-loop/switch region; other site 441771003853 The HCP family of iron-sulfur proteins includes hybrid cluster protein (HCP), acetyl-CoA synthase (ACS), and carbon monoxide dehydrogenase (CODH), all of which contain [Fe4-S4] metal clusters at their active sites. These proteins have a conserved...; Region: HCP_like; cl19102 441771003854 4Fe-4S dicluster domain; Region: Fer4_7; pfam12838 441771003855 N-acetylmuramic acid 6-phosphate etherase; Region: TIGR00274 441771003856 N-acetylmuramic acid 6-phosphate etherase. Members of this family contain the SIS (Sugar ISomerase) domain. The SIS domain is found in many phosphosugar isomerases and phosphosugar binding proteins. The bacterial cell wall sugar N-acetylmuramic acid...; Region: SIS_Etherase; cd05007 441771003857 putative active site [active] 441771003858 PTS system, sucrose-specific IIBC component; Region: PTS-II-BC-sucr; TIGR01996 441771003859 PTS_IIB, PTS system, glucose/sucrose specific IIB subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIB_glc; cl00164 441771003860 active site turn [active] 441771003861 phosphorylation site [posttranslational modification] 441771003862 Phosphotransferase system IIC components, glucose/maltose/N-acetylglucosamine-specific [Carbohydrate transport and metabolism]; Region: PtsG; COG1263 441771003863 Bacterial protein of unknown function (DUF871); Region: DUF871; pfam05913 441771003864 Putative glycolipid-binding; Region: Glycolipid_bind; pfam06475 441771003865 Uncharacterized ACR, YkgG family COG1556; Region: DUF162; pfam02589 441771003866 Putative cell wall binding repeat 2; Region: CW_binding_2; pfam04122 441771003867 Domain of unknown function (DUF4396); Region: DUF4396; pfam14342 441771003868 Putative cell wall binding repeat 2; Region: CW_binding_2; pfam04122 441771003869 Protein of unknown function (DUF1657); Region: DUF1657; pfam07870 441771003870 Four helix bundle sensory module for signal transduction; Region: 4HB_MCP_1; pfam12729 441771003871 Methyl-accepting chemotaxis protein [Cell motility and secretion / Signal transduction mechanisms]; Region: Tar; COG0840 441771003872 HAMP domain; Region: HAMP; pfam00672 441771003873 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cl19050 441771003874 dimer interface [polypeptide binding]; other site 441771003875 putative CheW interface [polypeptide binding]; other site 441771003876 ABC-type dipeptide transport system, periplasmic component [Amino acid transport and metabolism]; Region: DdpA; COG0747 441771003877 The substrate-binding component of an uncharacterized ABC-type nickel/dipeptide/oligopeptide-like import system contains the type 2 periplasmic binding fold; Region: PBP2_NikA_DppA_OppA_like_19; cd08518 441771003878 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppB; COG0601 441771003879 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 441771003880 dimer interface [polypeptide binding]; other site 441771003881 conserved gate region; other site 441771003882 putative PBP binding loops; other site 441771003883 ABC-ATPase subunit interface; other site 441771003884 nickel ABC transporter, permease subunit NikC; Region: nickel_nikC; TIGR02790 441771003885 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 441771003886 dimer interface [polypeptide binding]; other site 441771003887 conserved gate region; other site 441771003888 putative PBP binding loops; other site 441771003889 ABC-ATPase subunit interface; other site 441771003890 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 441771003891 nickel import ATP-binding protein NikD; Region: nickel_nikD; TIGR02770 441771003892 Walker A/P-loop; other site 441771003893 ATP binding site [chemical binding]; other site 441771003894 Q-loop/lid; other site 441771003895 ABC transporter signature motif; other site 441771003896 Walker B; other site 441771003897 D-loop; other site 441771003898 H-loop/switch region; other site 441771003899 ABC-type dipeptide/oligopeptide/nickel transport system, ATPase component [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppF; COG1124 441771003900 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 441771003901 Walker A/P-loop; other site 441771003902 ATP binding site [chemical binding]; other site 441771003903 Q-loop/lid; other site 441771003904 ABC transporter signature motif; other site 441771003905 Walker B; other site 441771003906 D-loop; other site 441771003907 H-loop/switch region; other site 441771003908 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550 441771003909 ABC-ATPase subunit interface; other site 441771003910 dimer interface [polypeptide binding]; other site 441771003911 putative PBP binding regions; other site 441771003912 ABC-type cobalt transport system, ATPase component [Inorganic ion transport and metabolism]; Region: CbiO; COG1122 441771003913 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 441771003914 Walker A/P-loop; other site 441771003915 ATP binding site [chemical binding]; other site 441771003916 Q-loop/lid; other site 441771003917 ABC transporter signature motif; other site 441771003918 Walker B; other site 441771003919 D-loop; other site 441771003920 H-loop/switch region; other site 441771003921 ABC-type metal ion transport system, periplasmic component/surface adhesin [Inorganic ion transport and metabolism]; Region: LraI; COG0803 441771003922 Metal binding protein AcdA. These proteins have been shown to function in the ABC uptake of Zn2+ and Mn2+ and in competence for genetic transformation and adhesion. The AcdA proteins belong to the TroA superfamily of helical backbone metal receptor...; Region: AdcA; cd01017 441771003923 metal binding site [ion binding]; metal-binding site 441771003924 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 441771003925 ATP binding site [chemical binding]; other site 441771003926 Superfamily II DNA and RNA helicases [DNA replication, recombination, and repair / Transcription / Translation, ribosomal structure and biogenesis]; Region: SrmB; COG0513 441771003927 putative Mg++ binding site [ion binding]; other site 441771003928 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 441771003929 nucleotide binding region [chemical binding]; other site 441771003930 ATP-binding site [chemical binding]; other site 441771003931 Mitochondrial degradasome RNA helicase subunit C terminal; Region: SUV3_C; pfam12513 441771003932 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 441771003933 metal binding site [ion binding]; metal-binding site 441771003934 active site 441771003935 I-site; other site 441771003936 NMT1-like family; Region: NMT1_2; cl17432 441771003937 ABC-type nitrate/sulfonate/bicarbonate transport systems, periplasmic components [Inorganic ion transport and metabolism]; Region: TauA; COG0715 441771003938 ABC-type nitrate/sulfonate/bicarbonate transport system, permease component [Inorganic ion transport and metabolism]; Region: TauC; COG0600 441771003939 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 441771003940 dimer interface [polypeptide binding]; other site 441771003941 conserved gate region; other site 441771003942 putative PBP binding loops; other site 441771003943 ABC-ATPase subunit interface; other site 441771003944 ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136 441771003945 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 441771003946 Walker A/P-loop; other site 441771003947 ATP binding site [chemical binding]; other site 441771003948 Q-loop/lid; other site 441771003949 ABC transporter signature motif; other site 441771003950 Walker B; other site 441771003951 D-loop; other site 441771003952 H-loop/switch region; other site 441771003953 Ferric uptake regulator(Fur) and related metalloregulatory proteins; typically iron-dependent, DNA-binding repressors and activators; Region: Fur_like; cd07153 441771003954 metal binding site 2 [ion binding]; metal-binding site 441771003955 putative DNA binding helix; other site 441771003956 metal binding site 1 [ion binding]; metal-binding site 441771003957 dimer interface [polypeptide binding]; other site 441771003958 structural Zn2+ binding site [ion binding]; other site 441771003959 Predicted DNA-binding proteins [General function prediction only]; Region: COG1342 441771003960 RNA polymerase sigma factor, sigma-70 family; Region: sigma70-ECF; TIGR02937 441771003961 DNA binding residues [nucleotide binding] 441771003962 Putative peptidoglycan binding domain; Region: PG_binding_1; pfam01471 441771003963 Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118 441771003964 Peptidase M14 carboxypeptidase family-like domain of Endopeptidase I; Region: M14_Endopeptidase_I; cd06229 441771003965 putative active site [active] 441771003966 Zn binding site [ion binding]; other site 441771003967 ribonuclease Z; Reviewed; Region: PRK00055 441771003968 putative fructoselysine transporter; Provisional; Region: frlA; PRK11357 441771003969 Transmembrane amino acid transporter protein; Region: Aa_trans; cl17468 441771003970 Pleckstrin homology (PH)-like domains in bacteria (PHb); Region: PH-like_bacteria; cd13225 441771003971 pentamer interface [polypeptide binding]; other site 441771003972 dodecaamer interface [polypeptide binding]; other site 441771003973 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: COG4585 441771003974 Histidine kinase; Region: HisKA_3; pfam07730 441771003975 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 441771003976 ATP binding site [chemical binding]; other site 441771003977 Mg2+ binding site [ion binding]; other site 441771003978 G-X-G motif; other site 441771003979 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 441771003980 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 441771003981 active site 441771003982 phosphorylation site [posttranslational modification] 441771003983 intermolecular recognition site; other site 441771003984 dimerization interface [polypeptide binding]; other site 441771003985 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 441771003986 DNA binding residues [nucleotide binding] 441771003987 dimerization interface [polypeptide binding]; other site 441771003988 ABC-type multidrug transport system, ATPase component [Defense mechanisms]; Region: CcmA; COG1131 441771003989 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 441771003990 Walker A/P-loop; other site 441771003991 ATP binding site [chemical binding]; other site 441771003992 Q-loop/lid; other site 441771003993 ABC transporter signature motif; other site 441771003994 Walker B; other site 441771003995 D-loop; other site 441771003996 H-loop/switch region; other site 441771003997 ABC-type multidrug transport system, permease component [Defense mechanisms]; Region: COG0842 441771003998 YhgE/Pip N-terminal domain; Region: pip_yhgE_Nterm; cl19580 441771003999 ABC-2 family transporter protein; Region: ABC2_membrane_3; pfam12698 441771004000 Proteins of this family catalyze the reduction of flavin or nitrocompounds using NAD(P)H as electron donor in a obligatory two-electron transfer, utilizing FMN or FAD as cofactor. They are often found to be homodimers. Enzymes of this family are...; Region: Nitro_FMN_reductase; cd02062 441771004001 FMN binding site [chemical binding]; other site 441771004002 dimer interface [polypeptide binding]; other site 441771004003 Cold-Shock Protein (CSP) contains an S1-like cold-shock domain (CSD) that is found in eukaryotes, prokaryotes, and archaea. CSP's include the major cold-shock proteins CspA and CspB in bacteria and the eukaryotic gene regulatory factor Y-box...; Region: CSP_CDS; cd04458 441771004004 DNA-binding site [nucleotide binding]; DNA binding site 441771004005 RNA-binding motif; other site 441771004006 M20 Peptidase D has specificity for beta-alanyl-L-histidine dipeptide; Region: M20_pepD; cd03890 441771004007 Xaa-His dipeptidase; Region: aa-his-dipept; TIGR01893 441771004008 metal binding site [ion binding]; metal-binding site 441771004009 dimer interface [polypeptide binding]; other site 441771004010 Pyridoxal kinase plays a key role in the synthesis of the active coenzyme pyridoxal-5'-phosphate (PLP), by catalyzing the phosphorylation of the precursor vitamin B6 in the presence of Zn2+ and ATP. Mammals are unable to synthesize PLP de novo and...; Region: pyridoxal_pyridoxamine_kinase; cd01173 441771004011 dimer interface [polypeptide binding]; other site 441771004012 pyridoxal binding site [chemical binding]; other site 441771004013 ATP binding site [chemical binding]; other site 441771004014 Peptide methionine sulfoxide reductase; Region: PMSR; pfam01625 441771004015 ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136 441771004016 ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255 441771004017 Walker A/P-loop; other site 441771004018 ATP binding site [chemical binding]; other site 441771004019 Q-loop/lid; other site 441771004020 ABC transporter signature motif; other site 441771004021 Walker B; other site 441771004022 D-loop; other site 441771004023 H-loop/switch region; other site 441771004024 ABC-type antimicrobial peptide transport system, permease component [Defense mechanisms]; Region: SalY; COG0577 441771004025 FtsX-like permease family; Region: FtsX; pfam02687 441771004026 FtsX-like permease family; Region: FtsX; pfam02687 441771004027 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 441771004028 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 441771004029 active site 441771004030 phosphorylation site [posttranslational modification] 441771004031 intermolecular recognition site; other site 441771004032 dimerization interface [polypeptide binding]; other site 441771004033 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 441771004034 DNA binding site [nucleotide binding] 441771004035 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 441771004036 His Kinase A (phosphoacceptor) domain; Region: HisKA; smart00388 441771004037 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 441771004038 ATP binding site [chemical binding]; other site 441771004039 Mg2+ binding site [ion binding]; other site 441771004040 G-X-G motif; other site 441771004041 ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136 441771004042 ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255 441771004043 Walker A/P-loop; other site 441771004044 ATP binding site [chemical binding]; other site 441771004045 Q-loop/lid; other site 441771004046 ABC transporter signature motif; other site 441771004047 Walker B; other site 441771004048 D-loop; other site 441771004049 H-loop/switch region; other site 441771004050 Domain of unknown function (DUF4163); Region: DUF4163; pfam13739 441771004051 Protein of unknown function (DUF3298); Region: DUF3298; pfam11738 441771004052 Protein of unknown function (DUF2804); Region: DUF2804; pfam10974 441771004053 putative C-S lyase; Region: C_S_lyase_PatB; TIGR04350 441771004054 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 441771004055 pyridoxal 5'-phosphate binding site [chemical binding]; other site 441771004056 homodimer interface [polypeptide binding]; other site 441771004057 catalytic residue [active] 441771004058 ABC-type amino acid transport system, permease component [Amino acid transport and metabolism]; Region: HisM; COG0765 441771004059 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 441771004060 dimer interface [polypeptide binding]; other site 441771004061 conserved gate region; other site 441771004062 putative PBP binding loops; other site 441771004063 ABC-ATPase subunit interface; other site 441771004064 ABC-type polar amino acid transport system, ATPase component [Amino acid transport and metabolism]; Region: GlnQ; COG1126 441771004065 ATP-binding cassette domain of the histidine and glutamine transporters; Region: ABC_HisP_GlnQ; cd03262 441771004066 Walker A/P-loop; other site 441771004067 ATP binding site [chemical binding]; other site 441771004068 Q-loop/lid; other site 441771004069 ABC transporter signature motif; other site 441771004070 Walker B; other site 441771004071 D-loop; other site 441771004072 H-loop/switch region; other site 441771004073 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 441771004074 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 441771004075 non-specific DNA binding site [nucleotide binding]; other site 441771004076 salt bridge; other site 441771004077 sequence-specific DNA binding site [nucleotide binding]; other site 441771004078 D-alanyl-D-alanine carboxypeptidase [Cell envelope biogenesis, outer membrane]; Region: DacC; COG1686 441771004079 Beta-lactamase enzyme family; Region: Beta-lactamase2; cl19191 441771004080 Coenzyme A pyrophosphatase (CoAse), a member of the Nudix hydrolase superfamily, functions to catalyze the elimination of oxidized inactive CoA, which can inhibit CoA-utilizing enzymes. The need of CoAses mainly arises under conditions of oxidative...; Region: CoAse; cd03426 441771004081 putative active site [active] 441771004082 putative CoA binding site [chemical binding]; other site 441771004083 nudix motif; other site 441771004084 metal binding site [ion binding]; metal-binding site 441771004085 Butanol dehydrogenase catalyzes the conversion of butyraldehyde to butanol with the cofactor NAD(P)H being oxidized in the process; Region: BDH; cd08187 441771004086 dimer interface [polypeptide binding]; other site 441771004087 active site 441771004088 metal binding site [ion binding]; metal-binding site 441771004089 Predicted membrane protein [Function unknown]; Region: COG1288 441771004090 nicotinate phosphoribosyltransferase; Validated; Region: PRK09243 441771004091 Nicotinate phosphoribosyltransferase (NAPRTase), subgroup A. Nicotinate phosphoribosyltransferase catalyses the formation of NAMN and PPi from 5-phosphoribosy -1-pyrophosphate (PRPP) and nicotinic acid, this is the first, and also rate limiting, reaction...; Region: NAPRTase_A; cd01570 441771004092 active site 441771004093 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 441771004094 Bacterial extracellular solute-binding proteins, family 3; Region: SBP_bac_3; pfam00497 441771004095 substrate binding pocket [chemical binding]; other site 441771004096 membrane-bound complex binding site; other site 441771004097 hinge residues; other site 441771004098 ABC-type amino acid transport system, permease component [Amino acid transport and metabolism]; Region: HisM; COG0765 441771004099 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 441771004100 dimer interface [polypeptide binding]; other site 441771004101 conserved gate region; other site 441771004102 putative PBP binding loops; other site 441771004103 ABC-ATPase subunit interface; other site 441771004104 Protein of unknown function (DUF523); Region: DUF523; cl00733 441771004105 Superfamily I DNA and RNA helicases [DNA replication, recombination, and repair]; Region: UvrD; COG0210 441771004106 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 441771004107 ATP binding site [chemical binding]; other site 441771004108 UvrD-like helicase C-terminal domain; Region: UvrD_C_2; pfam13538 441771004109 Phage tail protein; Region: Sipho_tail; cl17486 441771004110 Prophage endopeptidase tail; Region: Prophage_tail; cl19379 441771004111 Acetyltransferases [General function prediction only]; Region: RimI; COG0456 441771004112 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 441771004113 Coenzyme A binding pocket [chemical binding]; other site 441771004114 Protein of unknown function (DUF2762); Region: DUF2762; pfam10960 441771004115 N-acetylmuramoyl-L-alanine amidase or MurNAc-LAA (also known as peptidoglycan aminohydrolase, NAMLA amidase, NAMLAA, Amidase 3, and peptidoglycan amidase; EC 3.5.1.28) is an autolysin that hydrolyzes the amide bond between N-acetylmuramoyl and L-amino...; Region: MurNAc-LAA; cd02696 441771004116 active site 441771004117 metal binding site [ion binding]; metal-binding site 441771004118 Putative peptidoglycan binding domain; Region: PG_binding_1; pfam01471 441771004119 Coat F domain; Region: Coat_F; pfam07875 441771004120 Superfamily I DNA and RNA helicases [DNA replication, recombination, and repair]; Region: UvrD; COG0210 441771004121 UvrD-like helicase C-terminal domain; Region: UvrD_C_2; cl19402 441771004122 cell division protein FtsA; Region: ftsA; TIGR01174 441771004123 Cell division protein FtsA; Region: FtsA; smart00842 441771004124 Cell division protein FtsA; Region: FtsA; pfam14450 441771004125 Metal-dependent amidase/aminoacylase/carboxypeptidase [General function prediction only]; Region: AbgB; COG1473 441771004126 M20 Peptidase Aminoacylase 1 family; Region: M20_Acy1; cd03886 441771004127 metal binding site [ion binding]; metal-binding site 441771004128 dimer interface [polypeptide binding]; other site 441771004129 N-acetylmuramoyl-L-alanine amidase [Cell envelope biogenesis, outer membrane]; Region: AmiC; COG0860 441771004130 N-acetylmuramoyl-L-alanine amidase or MurNAc-LAA (also known as peptidoglycan aminohydrolase, NAMLA amidase, NAMLAA, Amidase 3, and peptidoglycan amidase; EC 3.5.1.28) is an autolysin that hydrolyzes the amide bond between N-acetylmuramoyl and L-amino...; Region: MurNAc-LAA; cd02696 441771004131 active site 441771004132 metal binding site [ion binding]; metal-binding site 441771004133 Pseudouridylate synthases, 23S RNA-specific [Translation, ribosomal structure and biogenesis]; Region: RluA; COG0564 441771004134 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 441771004135 RNA binding surface [nucleotide binding]; other site 441771004136 Pseudouridine synthase, RsuA/RluD family; Region: PseudoU_synth_RluCD_like; cd02869 441771004137 active site 441771004138 stage V sporulation protein B; Region: spore_V_B; TIGR02900 441771004139 Stage V sporulation protein B, also known as Stage III sporulation protein F, and related proteins; Region: MATE_SpoVB_like; cd13124 441771004140 stage V sporulation protein B; Region: spore_V_B; TIGR02900 441771004141 Multidrug and toxic compound extrusion family and similar proteins; Region: MATE_like; cl09326 441771004142 Ferritin-like superfamily of diiron-containing four-helix-bundle proteins; Region: Ferritin_like; cl00264 441771004143 dinuclear metal binding motif [ion binding]; other site 441771004144 Iron-containing alcohol dehydrogenase; Region: Fe-ADH8; cd08186 441771004145 putative active site [active] 441771004146 metal binding site [ion binding]; metal-binding site 441771004147 AAA domain; Region: AAA_32; pfam13654 441771004148 Pex19 protein family; Region: Pex19; pfam04614 441771004149 Formin Homology 2 Domain; Region: FH2; cl19758 441771004150 Predicted ATP-dependent protease [Posttranslational modification, protein turnover, chaperones]; Region: LonB; COG1067 441771004151 Lon protease (S16) C-terminal proteolytic domain; Region: Lon_C; pfam05362 441771004152 Zinc metalloprotease (elastase) [Amino acid transport and metabolism]; Region: LasB; COG3227 441771004153 Fungalysin/Thermolysin Propeptide Motif; Region: FTP; pfam07504 441771004154 Peptidase M4 family includes thermolysin, protealysin, aureolysin and neutral protease; Region: M4_neutral_protease; cd09597 441771004155 active site 441771004156 Zn binding site [ion binding]; other site 441771004157 Zinc metalloprotease (elastase) [Amino acid transport and metabolism]; Region: LasB; COG3227 441771004158 Peptidase propeptide and YPEB domain; Region: PepSY; pfam03413 441771004159 Peptidase Gluzincin family (thermolysin-like proteinases, TLPs) includes peptidases M1, M2, M3, M4, M13, M32 and M36 (fungalysins); Region: GluZincin; cl14813 441771004160 Peptidase M4 family includes thermolysin, protealysin, aureolysin and neutral protease; Region: M4_neutral_protease; cd09597 441771004161 active site 441771004162 Zn binding site [ion binding]; other site 441771004163 Zinc metalloprotease (elastase) [Amino acid transport and metabolism]; Region: LasB; COG3227 441771004164 Peptidase propeptide and YPEB domain; Region: PepSY; pfam03413 441771004165 Peptidase M4 family includes thermolysin, protealysin, aureolysin and neutral protease; Region: M4_neutral_protease; cd09597 441771004166 active site 441771004167 Zn binding site [ion binding]; other site 441771004168 Zinc metalloprotease (elastase) [Amino acid transport and metabolism]; Region: LasB; COG3227 441771004169 Peptidase propeptide and YPEB domain; Region: PepSY; pfam03413 441771004170 Peptidase M4 family includes thermolysin, protealysin, aureolysin and neutral protease; Region: M4_neutral_protease; cd09597 441771004171 active site 441771004172 Zn binding site [ion binding]; other site 441771004173 Zinc metalloprotease (elastase) [Amino acid transport and metabolism]; Region: LasB; COG3227 441771004174 Peptidase propeptide and YPEB domain; Region: PepSY; pfam03413 441771004175 Peptidase M4 family includes thermolysin, protealysin, aureolysin and neutral protease; Region: M4_neutral_protease; cd09597 441771004176 active site 441771004177 Zn binding site [ion binding]; other site 441771004178 Zinc metalloprotease (elastase) [Amino acid transport and metabolism]; Region: LasB; COG3227 441771004179 Fungalysin/Thermolysin Propeptide Motif; Region: FTP; pfam07504 441771004180 Peptidase M4 family includes thermolysin, protealysin, aureolysin and neutral protease; Region: M4_neutral_protease; cd09597 441771004181 active site 441771004182 Zn binding site [ion binding]; other site 441771004183 Nicotinate-nucleotide pyrophosphorylase [Coenzyme metabolism]; Region: NadC; COG0157 441771004184 Quinolinate phosphoribosyl transferase (QAPRTase or QPRTase), also called nicotinate-nucleotide pyrophosphorylase, is involved in the de novo synthesis of NAD in both prokaryotes and eukaryotes. It catalyses the reaction of quinolinic acid (QA) with...; Region: QPRTase; cd01572 441771004185 dimerization interface [polypeptide binding]; other site 441771004186 active site 441771004187 L-aspartate oxidase; Provisional; Region: PRK06175 441771004188 FAD binding domain; Region: FAD_binding_2; pfam00890 441771004189 Quinolinate synthetase A protein; Region: NadA; pfam02445 441771004190 Zinc peptidases M18, M20, M28, and M42; Region: Zinc_peptidase_like; cl14876 441771004191 metal binding site [ion binding]; metal-binding site 441771004192 channel protein, hemolysin III family; Region: hlyIII; TIGR01065 441771004193 GTP-binding protein YchF; Reviewed; Region: PRK09601 441771004194 YchF GTPase; Region: YchF; cd01900 441771004195 G1 box; other site 441771004196 GTP/Mg2+ binding site [chemical binding]; other site 441771004197 Switch I region; other site 441771004198 G2 box; other site 441771004199 Switch II region; other site 441771004200 G3 box; other site 441771004201 G4 box; other site 441771004202 G5 box; other site 441771004203 TGS_YchF_C: This subfamily represents TGS domain-containing YchF GTP-binding protein, a universally conserved GTPase whose function is unknown. The N-terminal domain of the YchF protein belongs to the Obg-like family of GTPases, and some members of the...; Region: TGS_YchF_C; cd04867 441771004204 cell division protein MraZ; Reviewed; Region: PRK00326 441771004205 MraZ protein; Region: MraZ; pfam02381 441771004206 MraZ protein; Region: MraZ; pfam02381 441771004207 16S rRNA m(4)C1402 methyltranserfase; Provisional; Region: PRK00050 441771004208 Cell division protein FtsL; Region: FtsL; cl11433 441771004209 stage V sporulation protein D; Region: spoVD_pbp; TIGR02214 441771004210 Penicillin-binding Protein dimerization domain; Region: PBP_dimer; pfam03717 441771004211 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; pfam00905 441771004212 PASTA domain of PBP2x-like proteins, first repeat. Penicillin-binding proteins (PBPs) are the major targets for beta-lactam antibiotics, like penicillins and cephalosporins. Beta-lactam antibiotics specifically inhibit transpeptidase activity by...; Region: PASTA_Pbp2x-like_1; cd06576 441771004213 PASTA domain of PBP2x-like proteins, second repeat. Penicillin-binding proteins (PBPs) are the major targets for beta-lactam antibiotics, like penicillins and cephalosporins. Beta-lactam antibiotics specifically inhibit transpeptidase activity by...; Region: PASTA_Pbp2x-like_2; cd06575 441771004214 UDP-N-acetylmuramoylalanyl-D-glutamate--2, 6-diaminopimelate ligase; Provisional; Region: murE; PRK00139 441771004215 Mur ligase family, catalytic domain; Region: Mur_ligase; pfam01225 441771004216 Mur ligase middle domain; Region: Mur_ligase_M; pfam08245 441771004217 Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875 441771004218 UDP-N-acetylmuramyl pentapeptide synthase [Cell envelope biogenesis, outer membrane]; Region: MurF; COG0770 441771004219 Mur ligase family, catalytic domain; Region: Mur_ligase; pfam01225 441771004220 Mur ligase middle domain; Region: Mur_ligase_M; pfam08245 441771004221 Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875 441771004222 Phospho-N-acetylmuramoyl-pentapeptide-transferase (mraY) is an enzyme responsible for the formation of the first lipid intermediate in the synthesis of bacterial cell wall peptidoglycan. It catalyzes the formation of...; Region: GT_MraY; cd06852 441771004223 Mg++ binding site [ion binding]; other site 441771004224 putative catalytic motif [active] 441771004225 putative substrate binding site [chemical binding]; other site 441771004226 Cell cycle protein; Region: FTSW_RODA_SPOVE; cl00511 441771004227 Cell division septal protein [Cell envelope biogenesis, outer membrane]; Region: FtsQ; COG1589 441771004228 POTRA domain, FtsQ-type; Region: POTRA_1; pfam08478 441771004229 Bacterial protein of unknown function (DUF881); Region: DUF881; pfam05949 441771004230 Protein of unknown function (DUF1290); Region: DUF1290; pfam06947 441771004231 Bacterial protein of unknown function (DUF881); Region: DUF881; pfam05949 441771004232 Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzymes, YBL036c-like proteins; Region: PLPDE_III_YBL036c_like; cd00635 441771004233 pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site 441771004234 catalytic residue [active] 441771004235 Protein of unknown function (DUF552); Region: DUF552; cl00775 441771004236 YGGT family; Region: YGGT; pfam02325 441771004237 photosystem II S4 domain protein; Region: PS_II_S4; TIGR03069 441771004238 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cl09940 441771004239 Cell division initiation protein [Cell division and chromosome partitioning]; Region: DivIVA; COG3599 441771004240 DivIVA protein; Region: DivIVA; pfam05103 441771004241 Dehydroquinate synthase (DHQS) catalyzes the conversion of DAHP to DHQ in shikimate pathway for aromatic compounds synthesis; Region: DHQS; cd08195 441771004242 active site 441771004243 dimer interface [polypeptide binding]; other site 441771004244 metal binding site [ion binding]; metal-binding site 441771004245 5'-methylthioadenosine/S-adenosylhomocysteine nucleosidase; Validated; Region: PRK05584 441771004246 3-deoxy-7-phosphoheptulonate synthase; Provisional; Region: PRK13398 441771004247 3-deoxy-7-phosphoheptulonate synthase; Reviewed; Region: PRK08673 441771004248 3-phosphoshikimate 1-carboxyvinyltransferase; Provisional; Region: PRK02427 441771004249 EPSP synthase domain. 3-phosphoshikimate 1-carboxyvinyltransferase (5-enolpyruvylshikimate-3-phosphate synthase) (EC 2.5.1.19) catalyses the reaction between shikimate-3-phosphate (S3P) and phosphoenolpyruvate (PEP) to form...; Region: EPSP_synthase; cd01556 441771004250 hinge; other site 441771004251 active site 441771004252 Prokaryotic dksA/traR C4-type zinc finger; Region: zf-dskA_traR; cl00755 441771004253 lipoprotein signal peptidase; Provisional; Region: PRK14791 441771004254 pseudouridine synthase, RluA family; Region: rluA_subfam; TIGR00005 441771004255 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 441771004256 RNA binding surface [nucleotide binding]; other site 441771004257 Pseudouridine synthase, RsuA/RluD family; Region: PseudoU_synth_RluCD_like; cd02869 441771004258 active site 441771004259 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 441771004260 active site 441771004261 Sulfate transporter family; Region: Sulfate_transp; cl19250 441771004262 Xanthine/uracil permeases [Nucleotide transport and metabolism]; Region: UraA; COG2233 441771004263 Methanothermobacter thermautotrophicus Mth212-like subfamily of the ExoIII family purinic/apyrimidinic (AP) endonucleases; Region: Mth212-like_AP-endo; cd09085 441771004264 active site 441771004265 putative catalytic site [active] 441771004266 phosphate binding site A [ion binding]; other site 441771004267 DNA binding site [nucleotide binding] 441771004268 metal binding site A [ion binding]; metal-binding site 441771004269 putative AP binding site [nucleotide binding]; other site 441771004270 putative metal binding site B [ion binding]; other site 441771004271 phosphate binding site B [ion binding]; other site 441771004272 Predicted N6-adenine-specific DNA methylase [DNA replication, recombination, and repair]; Region: COG0116 441771004273 THUMP domain associated with S-adenosylmethionine-dependent methyltransferases; Region: THUMP_AdoMetMT; cd11715 441771004274 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl17173 441771004275 Carbonic anhydrase; Region: Pro_CA; smart00947 441771004276 active site clefts [active] 441771004277 zinc binding site [ion binding]; other site 441771004278 dimer interface [polypeptide binding]; other site 441771004279 ABC-type molybdate transport system, periplasmic component [Inorganic ion transport and metabolism]; Region: ModA; COG0725 441771004280 ABC-type sulfate transport system, permease component [Posttranslational modification, protein turnover, chaperones]; Region: CysU; COG0555 441771004281 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 441771004282 dimer interface [polypeptide binding]; other site 441771004283 conserved gate region; other site 441771004284 putative PBP binding loops; other site 441771004285 ABC-ATPase subunit interface; other site 441771004286 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 441771004287 putative bacteriocin export ABC transporter, lactococcin 972 group; Region: L_ocin_972_ABC; TIGR03608 441771004288 Walker A/P-loop; other site 441771004289 ATP binding site [chemical binding]; other site 441771004290 Q-loop/lid; other site 441771004291 ABC transporter signature motif; other site 441771004292 Walker B; other site 441771004293 D-loop; other site 441771004294 H-loop/switch region; other site 441771004295 Predicted esterase of the alpha-beta hydrolase superfamily [General function prediction only]; Region: RssA; COG1752 441771004296 ExoU and VipD-like proteins; homologus to patatin, cPLA2, and iPLA2; Region: Pat_ExoU_VipD_like; cd07207 441771004297 active site 441771004298 nucleophile elbow; other site 441771004299 The URO-D _like protein superfamily includes bacterial and eukaryotic uroporphyrinogen decarboxylases (URO-D), coenzyme M methyltransferases and other putative bacterial methyltransferases. Uroporphyrinogen decarboxylase (URO-D) decarboxylates the four...; Region: URO-D_like; cd03465 441771004300 Na+/H+ antiporter [Energy production and conversion]; Region: NhaC; COG1757 441771004301 Anion permease ArsB/NhaD. These permeases have been shown to translocate sodium, arsenate, antimonite, sulfate and organic anions across biological membranes in all three kingdoms of life. A typical anion permease contains 8-13 transmembrane helices...; Region: ArsB_NhaD_permease; cl17221 441771004302 Anion permease ArsB/NhaD. These permeases have been shown to translocate sodium, arsenate, antimonite, sulfate and organic anions across biological membranes in all three kingdoms of life. A typical anion permease contains 8-13 transmembrane helices...; Region: ArsB_NhaD_permease; cl17221 441771004303 Uncharacterized metal-binding protein [General function prediction only]; Region: COG3894 441771004304 2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207 441771004305 catalytic loop [active] 441771004306 iron binding site [ion binding]; other site 441771004307 Domain of unknown function (DUF4445); Region: DUF4445; pfam14574 441771004308 Putative GTPases (G3E family) [General function prediction only]; Region: COG0523 441771004309 The Fer4_NifH superfamily contains a variety of proteins which share a common ATP-binding domain. Functionally, proteins in this superfamily use the energy from hydrolysis of NTP to transfer electron or ion; Region: Fer4_NifH; cl17203 441771004310 Uroporphyrinogen decarboxylase (URO-D); Region: URO-D; pfam01208 441771004311 Predicted cobalamin binding protein [General function prediction only]; Region: COG5012 441771004312 B12 binding domain of corrinoid proteins. A family of small methanogenic corrinoid proteins that bind methyl-Co(III) 5-hydroxybenzimidazolylcobamide as a cofactor. They play a role on the methanogenesis from trimethylamine, dimethylamine or...; Region: corrinoid_protein_B12-BD; cd02070 441771004313 B12 binding site [chemical binding]; other site 441771004314 cobalt ligand [ion binding]; other site 441771004315 methylcobalamin:coenzyme M methyltransferase; Validated; Region: PRK06252 441771004316 The URO-D _like protein superfamily includes bacterial and eukaryotic uroporphyrinogen decarboxylases (URO-D), coenzyme M methyltransferases and other putative bacterial methyltransferases. Uroporphyrinogen decarboxylase (URO-D) decarboxylates the four...; Region: URO-D_like; cd03465 441771004317 ABC-type metal ion transport system, ATPase component [Inorganic ion transport and metabolism]; Region: AbcC; COG1135 441771004318 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 441771004319 Walker A/P-loop; other site 441771004320 ATP binding site [chemical binding]; other site 441771004321 Q-loop/lid; other site 441771004322 ABC transporter signature motif; other site 441771004323 Walker B; other site 441771004324 D-loop; other site 441771004325 H-loop/switch region; other site 441771004326 This domain is found at the C-terminus of ABC transporter proteins involved in D-methionine transport as well as a number of ferredoxin-like proteins; Region: NIL; smart00930 441771004327 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 441771004328 dimer interface [polypeptide binding]; other site 441771004329 conserved gate region; other site 441771004330 ABC-ATPase subunit interface; other site 441771004331 NLPA lipoprotein; Region: Lipoprotein_9; cl19159 441771004332 MORN repeat; Region: MORN; cl14787 441771004333 Old yellow enzyme (OYE)-like FMN binding domain. OYE was the first flavin-dependent enzyme identified, however its true physiological role remains elusive to this day. Each monomer of OYE contains FMN as a non-covalently bound cofactor, uses NADPH as a...; Region: OYE_like_FMN_family; cd02803 441771004334 active site 441771004335 FMN binding site [chemical binding]; other site 441771004336 substrate binding site [chemical binding]; other site 441771004337 putative catalytic residue [active] 441771004338 Asparagine synthetase (aspartate-ammonia ligase) (AsnA) catalyses the conversion of L-aspartate to L-asparagine in the presence of ATP and ammonia. AsnA is a homodimeric enzyme which is structurally similiar to the catalytic core domain of class II...; Region: AsnA; cd00645 441771004339 dimer interface [polypeptide binding]; other site 441771004340 active site 441771004341 putative aminophosphonate oxidoreductase; Region: Phn_aa_oxid; TIGR03329 441771004342 FAD dependent oxidoreductase; Region: DAO; pfam01266 441771004343 Rieske Fe-S protein [Energy production and conversion]; Region: QcrA; COG0723 441771004344 YhfW family, C-terminal Rieske domain; YhfW is a protein of unknown function with an N-terminal DadA-like (glycine/D-amino acid dehydrogenase) domain and a C-terminal Rieske domain. The Rieske domain is a [2Fe-2S] cluster binding domain involved in...; Region: Rieske_YhfW_C; cd03477 441771004345 [2Fe-2S] cluster binding site [ion binding]; other site 441771004346 DNA topoisomerase III; Provisional; Region: PRK07726 441771004347 TOPRIM_TopoIA_TopoIII: The topoisomerase-primase (TORPIM) domain found in members of the type IA family of DNA topoisomerases (Topo IA) similar to topoisomerase III. Type IA DNA topoisomerases remove (relax) negative supercoils in the DNA by: cleaving...; Region: TOPRIM_TopoIA_TopoIII; cd03362 441771004348 active site 441771004349 putative interdomain interaction site [polypeptide binding]; other site 441771004350 putative metal-binding site [ion binding]; other site 441771004351 putative nucleotide binding site [chemical binding]; other site 441771004352 DNA Topoisomerase, subtype IA; DNA-binding, ATP-binding and catalytic domain of bacterial DNA topoisomerases I and III, and eukaryotic DNA topoisomerase III and eubacterial and archael reverse gyrases. Topoisomerases clevage single or double stranded DNA...; Region: TOP1Ac; cd00186 441771004353 domain I; other site 441771004354 DNA binding groove [nucleotide binding] 441771004355 phosphate binding site [ion binding]; other site 441771004356 domain II; other site 441771004357 domain III; other site 441771004358 nucleotide binding site [chemical binding]; other site 441771004359 catalytic site [active] 441771004360 domain IV; other site 441771004361 Mismatch repair ATPase (MutS family) [DNA replication, recombination, and repair]; Region: MutS; COG0249 441771004362 ATP-binding cassette domain of MutS-like homolog; Region: ABC_MutS-like; cd03283 441771004363 Walker A/P-loop; other site 441771004364 ATP binding site [chemical binding]; other site 441771004365 Q-loop/lid; other site 441771004366 ABC transporter signature motif; other site 441771004367 Walker B; other site 441771004368 D-loop; other site 441771004369 H-loop/switch region; other site 441771004370 Predicted oxidoreductases of the aldo/keto reductase family [General function prediction only]; Region: COG1453 441771004371 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 441771004372 active site 441771004373 catalytic tetrad [active] 441771004374 4Fe-4S dicluster domain; Region: Fer4_17; pfam13534 441771004375 This CD includes bacterial (Agrobacterium tumefaciens and Caulobacter crescentus ProX, and Clostridium sticklandii PrdX) and eukaryotic (Plasmodium falciparum N-terminal ProRS editing domain) sequences. The C. sticklandii PrdX protein, a homolog of the...; Region: PrdX_deacylase; cd04335 441771004376 putative deacylase active site [active] 441771004377 ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136 441771004378 ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255 441771004379 Walker A/P-loop; other site 441771004380 ATP binding site [chemical binding]; other site 441771004381 Q-loop/lid; other site 441771004382 ABC transporter signature motif; other site 441771004383 Walker B; other site 441771004384 D-loop; other site 441771004385 H-loop/switch region; other site 441771004386 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 441771004387 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 441771004388 Protein of unknown function (DUF523); Region: DUF523; pfam04463 441771004389 ABC-type sugar transport systems, ATPase components [Carbohydrate transport and metabolism]; Region: MalK; COG3839 441771004390 The N-terminal ATPase domain of the maltose transporter, MalK; Region: ABC_MalK_N; cd03301 441771004391 Walker A/P-loop; other site 441771004392 ATP binding site [chemical binding]; other site 441771004393 Q-loop/lid; other site 441771004394 ABC transporter signature motif; other site 441771004395 Walker B; other site 441771004396 D-loop; other site 441771004397 H-loop/switch region; other site 441771004398 TOBE domain; Region: TOBE; pfam03459 441771004399 ABC-type spermidine/putrescine transport system, permease component II [Amino acid transport and metabolism]; Region: PotC; COG1177 441771004400 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 441771004401 dimer interface [polypeptide binding]; other site 441771004402 conserved gate region; other site 441771004403 putative PBP binding loops; other site 441771004404 ABC-ATPase subunit interface; other site 441771004405 ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395 441771004406 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 441771004407 dimer interface [polypeptide binding]; other site 441771004408 conserved gate region; other site 441771004409 putative PBP binding loops; other site 441771004410 ABC-ATPase subunit interface; other site 441771004411 ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653 441771004412 Bacterial extracellular solute-binding protein; Region: SBP_bac_8; pfam13416 441771004413 L-lactate dehydrogenase; Reviewed; Region: ldh; PRK00066 441771004414 A subgroup of L-lactate dehydrogenases; Region: LDH_2; cd05292 441771004415 NAD binding site [chemical binding]; other site 441771004416 dimer interface [polypeptide binding]; other site 441771004417 substrate binding site [chemical binding]; other site 441771004418 tetramer (dimer of dimers) interface [polypeptide binding]; other site 441771004419 Transcriptional regulators [Transcription]; Region: FadR; COG2186 441771004420 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 441771004421 DNA-binding site [nucleotide binding]; DNA binding site 441771004422 This entry represents the C-terminal ligand binding domain of many members of the GntR family; Region: FCD; smart00895 441771004423 Putative redox-active protein (C_GCAxxG_C_C); Region: C_GCAxxG_C_C; pfam09719 441771004424 C4-dicarboxylate transporters of the Tellurite-resistance/Dicarboxylate Transporter (TDT) family; Region: TDT_C4-dicarb_trans; cd09325 441771004425 gating phenylalanine in ion channel; other site 441771004426 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 441771004427 putative active site [active] 441771004428 FOG: PAS/PAC domain [Signal transduction mechanisms]; Region: AtoS; COG2202 441771004429 heme pocket [chemical binding]; other site 441771004430 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 441771004431 putative active site [active] 441771004432 heme pocket [chemical binding]; other site 441771004433 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 441771004434 metal binding site [ion binding]; metal-binding site 441771004435 active site 441771004436 I-site; other site 441771004437 c-di-GMP phosphodiesterase class II (HD-GYP domain) [Signal transduction mechanisms]; Region: COG2206 441771004438 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 441771004439 Zn2+ binding site [ion binding]; other site 441771004440 Mg2+ binding site [ion binding]; other site 441771004441 Cysteine-rich 4 helical bundle widely conserved in bacteria; Region: DUF326; cd08026 441771004442 dimerization interface [polypeptide binding]; other site 441771004443 ligand binding domain of Tar- and Tsr-related chemoreceptors; Region: Tar_Tsr_LBD; cl00144 441771004444 Cache domain; Region: Cache_1; pfam02743 441771004445 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 441771004446 dimerization interface [polypeptide binding]; other site 441771004447 Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer); Region: MA; smart00283 441771004448 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 441771004449 dimer interface [polypeptide binding]; other site 441771004450 putative CheW interface [polypeptide binding]; other site 441771004451 Transcriptional regulators [Transcription]; Region: MarR; COG1846 441771004452 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cl17220 441771004453 dimerization interface [polypeptide binding]; other site 441771004454 putative Zn2+ binding site [ion binding]; other site 441771004455 putative DNA binding site [nucleotide binding]; other site 441771004456 Flavodoxin domain; Region: Flavodoxin_5; pfam12724 441771004457 Predicted transcriptional regulators [Transcription]; Region: COG1733 441771004458 This domain superfamily is found in a variety of structurally related metalloproteins, including the type I extradiol dioxygenases, glyoxalase I and a group of antibiotic resistance proteins; Region: Glo_EDI_BRP_like; cd06587 441771004459 active site 441771004460 metal binding site [ion binding]; metal-binding site 441771004461 methylated-DNA--protein-cysteine methyltransferase; Provisional; Region: PRK00901 441771004462 The DNA repair protein O6-alkylguanine-DNA alkyltransferase (ATase; also known as AGT, AGAT and MGMT) reverses O6-alkylation DNA damage by transferring O6-alkyl adducts to an active site cysteine irreversibly, without inducing DNA strand breaks. ATases...; Region: ATase; cd06445 441771004463 DNA binding site [nucleotide binding] 441771004464 active site 441771004465 TIM-barrel signal transduction protein; Region: TIM-br_sig_trns; cl15424 441771004466 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 441771004467 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 441771004468 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 441771004469 hypothetical protein; Provisional; Region: PRK02399 441771004470 TIM-barrel signal transduction protein; Region: TIM-br_sig_trns; pfam09370 441771004471 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 441771004472 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 441771004473 non-specific DNA binding site [nucleotide binding]; other site 441771004474 salt bridge; other site 441771004475 sequence-specific DNA binding site [nucleotide binding]; other site 441771004476 Cation transport ATPase [Inorganic ion transport and metabolism]; Region: MgtA; COG0474 441771004477 Cation transporting ATPase, C-terminus; Region: Cation_ATPase_C; pfam00689 441771004478 Predicted Co/Zn/Cd cation transporters [Inorganic ion transport and metabolism]; Region: MMT1; COG0053 441771004479 Dipeptide/tripeptide permease [Amino acid transport and metabolism]; Region: PTR2; COG3104 441771004480 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 441771004481 putative substrate translocation pore; other site 441771004482 Iron dependent repressor, N-terminal DNA binding domain; Region: Fe_dep_repress; pfam01325 441771004483 Helix-turn-helix diphteria tox regulatory element; Region: HTH_DTXR; smart00529 441771004484 Iron dependent repressor, metal binding and dimerization domain; Region: Fe_dep_repr_C; pfam02742 441771004485 Predicted signal transduction protein [Signal transduction mechanisms]; Region: COG1639 441771004486 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 441771004487 Zn2+ binding site [ion binding]; other site 441771004488 Mg2+ binding site [ion binding]; other site 441771004489 metallophosphatase superfamily, metallophosphatase domain; Region: MPP_superfamily; cl13995 441771004490 Cation transport ATPase [Inorganic ion transport and metabolism]; Region: MgtA; COG0474 441771004491 Cation transporter/ATPase, N-terminus; Region: Cation_ATPase_N; pfam00690 441771004492 E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122 441771004493 Putative hydrolase of sodium-potassium ATPase alpha subunit; Region: Hydrolase_like2; pfam13246 441771004494 haloacid dehalogenase-like hydrolase; Region: HAD; pfam12710 441771004495 Cation transporting ATPase, C-terminus; Region: Cation_ATPase_C; pfam00689 441771004496 This domain superfamily is found in a variety of structurally related metalloproteins, including the type I extradiol dioxygenases, glyoxalase I and a group of antibiotic resistance proteins; Region: Glo_EDI_BRP_like; cd06587 441771004497 active site 441771004498 DNA-binding transcriptional activator YeiL; Provisional; Region: PRK10402 441771004499 effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038 441771004500 ligand binding site [chemical binding]; other site 441771004501 flexible hinge region; other site 441771004502 helix_turn_helix, cAMP Regulatory protein C-terminus; DNA binding domain of prokaryotic regulatory proteins belonging to the catabolite activator protein family; Region: HTH_CRP; cl17320 441771004503 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 441771004504 dimerization interface [polypeptide binding]; other site 441771004505 DNA binding residues [nucleotide binding] 441771004506 Putative zinc ribbon domain; Region: Zn_ribbon_2; pfam12674 441771004507 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3708 441771004508 Predicted transcriptional regulator [Transcription]; Region: COG2378 441771004509 HTH domain; Region: HTH_11; pfam08279 441771004510 WYL domain; Region: WYL; pfam13280 441771004511 Benzoyl-CoA reductase/2-hydroxyglutaryl-CoA dehydratase subunit, BcrC/BadD/HgdB [Amino acid transport and metabolism]; Region: HgdB; COG1775 441771004512 2-hydroxyglutaryl-CoA dehydratase, D-component; Region: HGD-D; pfam06050 441771004513 BadF/BadG/BcrA/BcrD ATPase family; Region: BcrAD_BadFG; cl17271 441771004514 6-pyruvoyl tetrahydropterin synthase; Region: PTPS; pfam01242 441771004515 active site 441771004516 putative 7-cyano-7-deazaguanosine (preQ0) biosynthesis protein QueE, clostridial; Region: rSAM_QueE_Clost; TIGR03963 441771004517 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 441771004518 FeS/SAM binding site; other site 441771004519 GTP cyclohydrolase I; Provisional; Region: folE; PRK09347 441771004520 active site 441771004521 ExsB is a transcription regulator related protein. It is a subfamily of a Adenosine nucleotide binding superfamily of proteins. This protein family is represented by a single member in nearly every completed large (> 1000 genes) prokaryotic genome. In...; Region: ExsB; cd01995 441771004522 Ligand Binding Site [chemical binding]; other site 441771004523 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cl19050 441771004524 dimer interface [polypeptide binding]; other site 441771004525 putative CheW interface [polypeptide binding]; other site 441771004526 Protein of unknown function (DUF975); Region: DUF975; cl10504 441771004527 Transcriptional regulator, contains sigma factor-related N-terminal domain [Transcription]; Region: DeoR; COG2390 441771004528 helix_turn_helix, cAMP Regulatory protein C-terminus; DNA binding domain of prokaryotic regulatory proteins belonging to the catabolite activator protein family; Region: HTH_CRP; cl17320 441771004529 Putative sugar-binding domain; Region: Sugar-bind; pfam04198 441771004530 2-deoxyribose-5-phosphate aldolase (DERA) of the DeoC family; Region: DeoC; cd00959 441771004531 intersubunit interface [polypeptide binding]; other site 441771004532 active site 441771004533 catalytic residue [active] 441771004534 Ribokinase catalyses the phosphorylation of ribose to ribose-5-phosphate using ATP. This reaction is the first step in the ribose metabolism. It traps ribose within the cell after uptake and also prepares the sugar for use in the synthesis of nucleotides...; Region: ribokinase; cd01174 441771004535 substrate binding site [chemical binding]; other site 441771004536 dimer interface [polypeptide binding]; other site 441771004537 ATP binding site [chemical binding]; other site 441771004538 ATP phosphoribosyltransferase regulatory subunit; Provisional; Region: hisZ; PRK12292 441771004539 Class II Histidinyl-tRNA synthetase (HisRS)-like catalytic core domain. HisRS is a homodimer. It is responsible for the attachment of histidine to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for...; Region: HisRS-like_core; cd00773 441771004540 dimer interface [polypeptide binding]; other site 441771004541 motif 1; other site 441771004542 active site 441771004543 motif 2; other site 441771004544 motif 3; other site 441771004545 ATP phosphoribosyltransferase catalytic subunit; Reviewed; Region: hisG; PRK01686 441771004546 ATP phosphoribosyltransferase [Amino acid transport and metabolism]; Region: HisG; COG0040 441771004547 Histidinol dehydrogenase, HisD, E.C 1.1.1.23. Histidinol dehydrogenase catalyzes the last two steps in the L-histidine biosynthesis pathway, which is conserved in bacteria, archaea, fungi, and plants. These last two steps are (i) the NAD-dependent...; Region: Histidinol_dh; cd06572 441771004548 histidinol dehydrogenase; Region: hisD; TIGR00069 441771004549 NAD binding site [chemical binding]; other site 441771004550 dimerization interface [polypeptide binding]; other site 441771004551 product binding site; other site 441771004552 substrate binding site [chemical binding]; other site 441771004553 zinc binding site [ion binding]; other site 441771004554 catalytic residues [active] 441771004555 Imidazoleglycerol-phosphate dehydratase; Region: IGPD; cd07914 441771004556 putative active site pocket [active] 441771004557 4-fold oligomerization interface [polypeptide binding]; other site 441771004558 metal binding residues [ion binding]; metal-binding site 441771004559 3-fold/trimer interface [polypeptide binding]; other site 441771004560 imidazole glycerol phosphate synthase subunit HisH; Provisional; Region: hisH; PRK13142 441771004561 Type 1 glutamine amidotransferase (GATase1) domain found in imidazole glycerol phosphate synthase (IGPS); Region: GATase1_IGP_Synthase; cd01748 441771004562 putative active site [active] 441771004563 oxyanion strand; other site 441771004564 catalytic triad [active] 441771004565 HisA. Phosphoribosylformimino-5-aminoimidazole carboxamide ribonucleotide (ProFAR) isomerase catalyzes the fourth step in histidine biosynthesis, an isomerisation of the aminoaldose moiety of ProFAR to the aminoketose of PRFAR (N-(5'-phospho-D-1...; Region: HisA; cd04732 441771004566 catalytic residues [active] 441771004567 histidinol-phosphate aminotransferase; Provisional; Region: PRK05387 441771004568 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 441771004569 pyridoxal 5'-phosphate binding site [chemical binding]; other site 441771004570 homodimer interface [polypeptide binding]; other site 441771004571 catalytic residue [active] 441771004572 The cyclase subunit of imidazoleglycerol phosphate synthase (HisF). Imidazole glycerol phosphate synthase (IGPS) catalyzes the fifth step of histidine biosynthesis, the formation of the imidazole ring. IGPS converts N1-(5'-phosphoribulosyl)...; Region: HisF; cd04731 441771004573 substrate binding site [chemical binding]; other site 441771004574 glutamase interaction surface [polypeptide binding]; other site 441771004575 phosphoribosyl-AMP cyclohydrolase; Reviewed; Region: hisI; PRK00051 441771004576 Nucleoside Triphosphate Pyrophosphohydrolase (EC 3.6.1.8) MazG-like domain found in Escherichia coli phosphoribosyl-ATP pyrophosphohydrolase (HisIE or PRATP-PH) and its homologs; Region: NTP-PPase_HisIE_like; cd11534 441771004577 metal binding site [ion binding]; metal-binding site 441771004578 Sulphur transport; Region: Sulf_transp; cl19477 441771004579 SirA, YedF, and YeeD. Two-layered alpha/beta sandwich domain. SirA (also known as UvrY, and YhhP) belongs to a family of bacterial two-component response regulators that controls secondary metabolism and virulence. The other member of this...; Region: SirA_YedF_YeeD; cd00291 441771004580 CPxP motif; other site 441771004581 Sulphur transport; Region: Sulf_transp; cl19477 441771004582 Transcriptional regulator [Transcription]; Region: LysR; COG0583 441771004583 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 441771004584 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 441771004585 dimerization interface [polypeptide binding]; other site 441771004586 Na+/alanine symporter [Amino acid transport and metabolism]; Region: AlsT; COG1115 441771004587 CoA-disulfide reductase; Region: CoA_CoA_reduc; TIGR03385 441771004588 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl19134 441771004589 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 441771004590 Pyridine nucleotide-disulphide oxidoreductase, dimerization domain; Region: Pyr_redox_dim; pfam02852 441771004591 Rhodanese Homology Domain (RHOD); an alpha beta fold domain found duplicated in the rhodanese protein. The cysteine containing enzymatically active version of the domain is also found in the Cdc25 class of protein phosphatases and a variety of proteins...; Region: RHOD; cd00158 441771004592 active site residue [active] 441771004593 Sulphur transport; Region: Sulf_transp; cl19477 441771004594 Sulphur transport; Region: Sulf_transp; cl19477 441771004595 gallidermin-class lantibiotic protection ABC transporter, ATP-binding subunit; Region: galliderm_ABC; TIGR03740 441771004596 ATP-binding cassette domain of the bacitracin-resistance transporter; Region: ABC_BcrA_bacitracin_resist; cd03268 441771004597 Walker A/P-loop; other site 441771004598 ATP binding site [chemical binding]; other site 441771004599 Q-loop/lid; other site 441771004600 ABC transporter signature motif; other site 441771004601 Walker B; other site 441771004602 D-loop; other site 441771004603 H-loop/switch region; other site 441771004604 lantibiotic protection ABC transporter permease subunit, MutE/EpiE family; Region: lanti_perm_MutE; TIGR03732 441771004605 lantibiotic protection ABC transporter permease subunit, MutG family; Region: lanti_perm_MutG; TIGR03733 441771004606 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 441771004607 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 441771004608 active site 441771004609 phosphorylation site [posttranslational modification] 441771004610 intermolecular recognition site; other site 441771004611 dimerization interface [polypeptide binding]; other site 441771004612 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 441771004613 DNA binding site [nucleotide binding] 441771004614 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 441771004615 HAMP domain; Region: HAMP; pfam00672 441771004616 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 441771004617 dimer interface [polypeptide binding]; other site 441771004618 phosphorylation site [posttranslational modification] 441771004619 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 441771004620 ATP binding site [chemical binding]; other site 441771004621 Mg2+ binding site [ion binding]; other site 441771004622 G-X-G motif; other site 441771004623 arginine deiminase; Provisional; Region: PRK01388 441771004624 arginine-ornithine antiporter; Region: arg_ornith_anti; TIGR03810 441771004625 Transmembrane amino acid transporter protein; Region: Aa_trans; cl17468 441771004626 Predicted membrane protein, hemolysin III homolog [General function prediction only]; Region: COG1272 441771004627 Domain of unknown function (DUF1836); Region: DUF1836; pfam08876 441771004628 HD domain; Region: HD_3; pfam13023 441771004629 YmaF family; Region: YmaF; pfam12788 441771004630 Bacterial SNF2 helicase associated; Region: SNF2_assoc; pfam08455 441771004631 SNF2 family N-terminal domain; Region: SNF2_N; pfam00176 441771004632 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 441771004633 ATP binding site [chemical binding]; other site 441771004634 putative Mg++ binding site [ion binding]; other site 441771004635 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 441771004636 nucleotide binding region [chemical binding]; other site 441771004637 ATP-binding site [chemical binding]; other site 441771004638 Nucleotidyltransferase (NT) domain of RelA- and SpoT-like ppGpp synthetases and hydrolases; Region: NT_Rel-Spo_like; cd05399 441771004639 synthetase active site [active] 441771004640 NTP binding site [chemical binding]; other site 441771004641 metal binding site [ion binding]; metal-binding site 441771004642 Domain of unknown function (DUF2383); Region: DUF2383; cl17556 441771004643 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 441771004644 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 441771004645 ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132 441771004646 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 441771004647 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 441771004648 Walker A/P-loop; other site 441771004649 ATP binding site [chemical binding]; other site 441771004650 Q-loop/lid; other site 441771004651 ABC transporter signature motif; other site 441771004652 Walker B; other site 441771004653 D-loop; other site 441771004654 H-loop/switch region; other site 441771004655 ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132 441771004656 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 441771004657 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 441771004658 Walker A/P-loop; other site 441771004659 ATP binding site [chemical binding]; other site 441771004660 Q-loop/lid; other site 441771004661 ABC transporter signature motif; other site 441771004662 Walker B; other site 441771004663 D-loop; other site 441771004664 H-loop/switch region; other site 441771004665 Transcriptional regulators [Transcription]; Region: PurR; COG1609 441771004666 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 441771004667 DNA binding site [nucleotide binding] 441771004668 domain linker motif; other site 441771004669 Ligand-binding domain of uncharacterized transcription regulator ycjW which is a member of the LacI-GalR family repressors; Region: PBP1_ycjW_transcription_regulator_like; cd06294 441771004670 putative dimerization interface [polypeptide binding]; other site 441771004671 putative ligand binding site [chemical binding]; other site 441771004672 ROK family protein (putative glucokinase); Region: ROK_glcA_fam; TIGR00744 441771004673 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cd00012 441771004674 nucleotide binding site [chemical binding]; other site 441771004675 alpha,alpha-phosphotrehalase; Region: trehalose_treC; TIGR02403 441771004676 Alpha amylase catalytic domain found in Sucrose isomerases, oligo-1,6-glucosidase (also called isomaltase; sucrase-isomaltase; alpha-limit dextrinase), dextran glucosidase (also called glucan 1,6-alpha-glucosidase), and related proteins; Region: AmyAc_SI_OligoGlu_DGase; cd11333 441771004677 Ca binding site [ion binding]; other site 441771004678 active site 441771004679 catalytic site [active] 441771004680 PTS system, IIBC component; Region: PTS-II-BC-unk1; TIGR02003 441771004681 Phosphotransferase system IIC components, glucose/maltose/N-acetylglucosamine-specific [Carbohydrate transport and metabolism]; Region: PtsG; COG1263 441771004682 PTS_IIB, PTS system, glucose/sucrose specific IIB subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIB_glc; cd00212 441771004683 active site turn [active] 441771004684 phosphorylation site [posttranslational modification] 441771004685 putative sporulation protein YtaF; Region: spore_YtaF; TIGR02840 441771004686 Domain of unknown function DUF; Region: DUF204; pfam02659 441771004687 Domain of unknown function DUF; Region: DUF204; pfam02659 441771004688 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3323 441771004689 Domain of unknown function (DUF3794); Region: DUF3794; pfam12673 441771004690 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 441771004691 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 441771004692 dimerization interface [polypeptide binding]; other site 441771004693 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 441771004694 dimer interface [polypeptide binding]; other site 441771004695 phosphorylation site [posttranslational modification] 441771004696 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 441771004697 ATP binding site [chemical binding]; other site 441771004698 Mg2+ binding site [ion binding]; other site 441771004699 G-X-G motif; other site 441771004700 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 441771004701 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 441771004702 active site 441771004703 phosphorylation site [posttranslational modification] 441771004704 intermolecular recognition site; other site 441771004705 dimerization interface [polypeptide binding]; other site 441771004706 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 441771004707 DNA binding site [nucleotide binding] 441771004708 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 441771004709 oxalate/formate antiporter family transporter; Region: 2A0111; TIGR00890 441771004710 putative substrate translocation pore; other site 441771004711 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 441771004712 haloacid dehalogenase-like hydrolase; Region: Hydrolase_3; pfam08282 441771004713 active site 441771004714 motif I; other site 441771004715 motif II; other site 441771004716 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 441771004717 Transcriptional regulators of sugar metabolism [Transcription / Carbohydrate transport and metabolism]; Region: GlpR; COG1349 441771004718 helix_turn_helix, Deoxyribose operon repressor; Region: HTH_DEOR; smart00420 441771004719 DeoR C terminal sensor domain; Region: DeoRC; pfam00455 441771004720 RNA polymerase sigma factor, sigma-70 family; Region: sigma70-ECF; TIGR02937 441771004721 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 441771004722 DNA binding residues [nucleotide binding] 441771004723 YvrJ protein family; Region: YvrJ; pfam12841 441771004724 Peptidase family M9 N-terminal; Region: Peptidase_M9_N; pfam08453 441771004725 Peptidase Gluzincin family (thermolysin-like proteinases, TLPs) includes peptidases M1, M2, M3, M4, M13, M32 and M36 (fungalysins); Region: GluZincin; cl14813 441771004726 polycystic kidney disease I (PKD) domain; similar to other cell-surface modules, with an IG-like fold; domain probably functions as a ligand binding site in protein-protein or protein-carbohydrate interactions; a single instance of the repeat is...; Region: PKD; cd00146 441771004727 FOG: PKD repeat [General function prediction only]; Region: COG3291 441771004728 Bacterial pre-peptidase C-terminal domain; Region: PPC; pfam04151 441771004729 Bacterial pre-peptidase C-terminal domain; Region: PPC; pfam04151 441771004730 Methylenetetrahydrofolate reductase (MTHFR). 5,10-Methylenetetrahydrofolate is reduced to 5-methyltetrahydrofolate by methylenetetrahydrofolate reductase, a cytoplasmic, NAD(P)-dependent enzyme. 5-methyltetrahydrofolate is utilized by methionine synthase...; Region: MTHFR; cd00537 441771004731 FAD binding site [chemical binding]; other site 441771004732 Vitamin B12 dependent methionine synthase, activation domain; Region: Met_synt_B12; pfam02965 441771004733 Homocysteine S-methyltransferase; Region: S-methyl_trans; cl14105 441771004734 Pterin binding enzymes. This family includes dihydropteroate synthase (DHPS) and cobalamin-dependent methyltransferases such as methyltetrahydrofolate, corrinoid iron-sulfur protein methyltransferase (MeTr) and methionine synthase (MetH). DHPS, a...; Region: Pterin_binding; cl00219 441771004735 substrate binding pocket [chemical binding]; other site 441771004736 dimer interface [polypeptide binding]; other site 441771004737 inhibitor binding site; inhibition site 441771004738 B12 binding domain of corrinoid proteins. A family of small methanogenic corrinoid proteins that bind methyl-Co(III) 5-hydroxybenzimidazolylcobamide as a cofactor. They play a role on the methanogenesis from trimethylamine, dimethylamine or...; Region: corrinoid_protein_B12-BD; cd02070 441771004739 methyltransferase cognate corrinoid proteins, Methanosarcina family; Region: pyl_corrinoid; TIGR02370 441771004740 B12 binding site [chemical binding]; other site 441771004741 cobalt ligand [ion binding]; other site 441771004742 hypothetical protein; Provisional; Region: PRK12705 441771004743 RNA polymerase factor sigma-70; Validated; Region: PRK06811 441771004744 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 441771004745 Sigma-70, region 4; Region: Sigma70_r4_2; pfam08281 441771004746 DNA binding residues [nucleotide binding] 441771004747 Domain of unknown function (DUF4179); Region: DUF4179; pfam13786 441771004748 Conserved hypothetical protein (Lin0512_fam); Region: Lin0512_fam; cl09807 441771004749 Thiamine pyrophosphate (TPP) family, E1 of PDC_ADC_BCADC subfamily, TPP-binding module; composed of proteins similar to the E1 components of the human pyruvate dehydrogenase complex (PDC), the acetoin dehydrogenase complex (ADC) and the branched chain...; Region: TPP_E1_PDC_ADC_BCADC; cd02000 441771004750 tetramer interface [polypeptide binding]; other site 441771004751 TPP-binding site [chemical binding]; other site 441771004752 heterodimer interface [polypeptide binding]; other site 441771004753 phosphorylation loop region [posttranslational modification] 441771004754 Pyruvate/2-oxoglutarate dehydrogenase complex, dehydrogenase (E1) component, eukaryotic type, beta subunit [Energy production and conversion]; Region: AcoB; COG0022 441771004755 Pyrimidine (PYR) binding domain of the beta subunits of the E1 components of human pyruvate dehydrogenase complex (E1- PDHc) and related proteins; Region: TPP_PYR_E1-PDHc-beta_like; cd07036 441771004756 alpha subunit interface [polypeptide binding]; other site 441771004757 TPP binding site [chemical binding]; other site 441771004758 heterodimer interface [polypeptide binding]; other site 441771004759 Transketolase, C-terminal domain; Region: Transketolase_C; pfam02780 441771004760 Predicted inorganic polyphosphate/ATP-NAD kinase [General function prediction only]; Region: COG3199 441771004761 branched-chain alpha-keto acid dehydrogenase subunit E2; Reviewed; Region: PRK11856 441771004762 Lipoyl domain of the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases. 2-oxo acid dehydrogenase multienzyme complexes, like pyruvate dehydrogenase (PDH), 2-oxoglutarate dehydrogenase (OGDH) and branched-chain 2-oxo acid...; Region: lipoyl_domain; cd06849 441771004763 E3 interaction surface; other site 441771004764 lipoyl attachment site [posttranslational modification]; other site 441771004765 e3 binding domain; Region: E3_binding; pfam02817 441771004766 e3 binding domain; Region: E3_binding; pfam02817 441771004767 2-oxoacid dehydrogenases acyltransferase (catalytic domain); Region: 2-oxoacid_dh; pfam00198 441771004768 dihydrolipoamide dehydrogenase; Region: lipoamide_DH; TIGR01350 441771004769 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl19134 441771004770 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 441771004771 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl19134 441771004772 Pyridine nucleotide-disulphide oxidoreductase, dimerization domain; Region: Pyr_redox_dim; pfam02852 441771004773 lipoyltransferase and lipoate-protein ligase; Region: lipoyltrans; TIGR00545 441771004774 Lipoate-protein ligase A [Coenzyme metabolism]; Region: LplA; COG0095 441771004775 Bacterial lipoate protein ligase C-terminus; Region: Lip_prot_lig_C; pfam10437 441771004776 ABC-type proline/glycine betaine transport systems, ATPase components [Amino acid transport and metabolism]; Region: OpuBA; COG1125 441771004777 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 441771004778 Walker A/P-loop; other site 441771004779 ATP binding site [chemical binding]; other site 441771004780 Q-loop/lid; other site 441771004781 ABC transporter signature motif; other site 441771004782 Walker B; other site 441771004783 D-loop; other site 441771004784 H-loop/switch region; other site 441771004785 FOG: CBS domain [General function prediction only]; Region: COG0517 441771004786 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains in association with the ABC transporter OpuCA. OpuCA is the ATP binding component of a bacterial solute transporter that serves a protective role to cells growing...; Region: CBS_pair_ABC_OpuCA_assoc2; cd04583 441771004787 ABC-type arginine/histidine transport system, permease component [Amino acid transport and metabolism]; Region: ArtM; COG4160 441771004788 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 441771004789 dimer interface [polypeptide binding]; other site 441771004790 conserved gate region; other site 441771004791 putative PBP binding loops; other site 441771004792 ABC-ATPase subunit interface; other site 441771004793 Periplasmic glycine betaine/choline-binding (lipo)protein of an ABC-type transport system (osmoprotectant binding protein) [Cell envelope biogenesis, outer membrane]; Region: OpuBC; COG1732 441771004794 threonine synthase; Validated; Region: PRK09225 441771004795 Threonine synthase catalyzes the final step of threonine biosynthesis. The conversion of O-phosphohomoserine into threonine and inorganic phosphate is pyridoxal 5'-phosphate dependent. The Thr-synth_1 CD includes members from higher plants; Region: Thr-synth_2; cd01560 441771004796 pyridoxal 5'-phosphate binding site [chemical binding]; other site 441771004797 catalytic residue [active] 441771004798 homoserine kinase; Provisional; Region: PRK01212 441771004799 GHMP kinases N terminal domain; Region: GHMP_kinases_N; pfam00288 441771004800 aspartate kinase; Reviewed; Region: PRK09034 441771004801 Amino Acid Kinases (AAK) superfamily, catalytic domain; present in such enzymes like N-acetylglutamate kinase (NAGK), carbamate kinase (CK), aspartokinase (AK), glutamate-5-kinase (G5K) and UMP kinase (UMPK). The AAK superfamily includes kinases that...; Region: AAK; cl00452 441771004802 nucleotide binding site [chemical binding]; other site 441771004803 substrate binding site [chemical binding]; other site 441771004804 ACT domains located C-terminal to the catalytic domain of the lysine plus threonine-sensitive aspartokinase isoenzyme AKIII; Region: ACT_AKiii-YclM-BS_1; cd04911 441771004805 allosteric regulatory residue; other site 441771004806 ACT domains located C-terminal to the catalytic domain of the lysine plus threonine-sensitive aspartokinase isoenzyme AKIII; Region: ACT_AKiii-YclM-BS_2; cd04916 441771004807 homoserine dehydrogenase; Provisional; Region: PRK06349 441771004808 Homoserine dehydrogenase, NAD binding domain; Region: NAD_binding_3; pfam03447 441771004809 Homoserine dehydrogenase; Region: Homoserine_dh; pfam00742 441771004810 ACT_HSDH_Hom CD includes the C-terminal ACT domain of the NAD(P)H-dependent, homoserine dehydrogenase (HSDH) and related domains; Region: ACT_HSDH-Hom; cd04881 441771004811 Transcriptional activator of acetoin/glycerol metabolism [Secondary metabolites biosynthesis, transport, and catabolism / Transcription]; Region: AcoR; COG3284 441771004812 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 441771004813 putative active site [active] 441771004814 heme pocket [chemical binding]; other site 441771004815 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 441771004816 Walker A motif; other site 441771004817 ATP binding site [chemical binding]; other site 441771004818 Walker B motif; other site 441771004819 arginine finger; other site 441771004820 Bacterial regulatory protein, Fis family; Region: HTH_8; pfam02954 441771004821 NADPH-dependent butanol dehydrogenase involved in the butanol and ethanol formation pathway in bacteria; Region: NADPH_BDH; cd08179 441771004822 putative active site [active] 441771004823 metal binding site [ion binding]; metal-binding site 441771004824 ferredoxin-NADP(+) reductase subunit alpha; Reviewed; Region: PRK06222 441771004825 FAD/NAD binding domain in the electron transfer subunit of dihydroorotate dehydrogenase-like proteins. Dihydroorotate dehydrogenases (DHODs) catalyze the only redox reaction in pyrimidine de novo biosynthesis. They catalyze the oxidation of (S)...; Region: DHOD_e_trans_like1; cd06219 441771004826 FAD binding pocket [chemical binding]; other site 441771004827 FAD binding motif [chemical binding]; other site 441771004828 phosphate binding motif [ion binding]; other site 441771004829 beta-alpha-beta structure motif; other site 441771004830 NAD binding pocket [chemical binding]; other site 441771004831 Iron coordination center [ion binding]; other site 441771004832 putative oxidoreductase; Provisional; Region: PRK12831 441771004833 Dihydroprymidine dehydrogenase domain II, 4Fe-4S cluster; Region: Fer4_20; pfam14691 441771004834 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl19134 441771004835 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 441771004836 Transcriptional activator of acetoin/glycerol metabolism [Secondary metabolites biosynthesis, transport, and catabolism / Transcription]; Region: AcoR; COG3284 441771004837 PAS domain; Region: PAS; smart00091 441771004838 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 441771004839 Walker A motif; other site 441771004840 ATP binding site [chemical binding]; other site 441771004841 Walker B motif; other site 441771004842 arginine finger; other site 441771004843 Bacterial regulatory protein, Fis family; Region: HTH_8; pfam02954 441771004844 Pentapeptide repeats (9 copies); Region: Pentapeptide_4; pfam13599 441771004845 Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805 441771004846 Bacterial surface proteins containing Ig-like domains [Cell motility and secretion]; Region: COG5492 441771004847 Bacterial Ig-like domain (group 2); Region: Big_2; pfam02368 441771004848 Domain of unknown function (DUF1508); Region: DUF1508; cl01356 441771004849 N-acetylmuramoyl-L-alanine amidase or MurNAc-LAA (also known as peptidoglycan aminohydrolase, NAMLA amidase, NAMLAA, Amidase 3, and peptidoglycan amidase; EC 3.5.1.28) is an autolysin that hydrolyzes the amide bond between N-acetylmuramoyl and L-amino...; Region: MurNAc-LAA; cl02713 441771004850 Bacterial SH3 domain; Region: SH3_3; pfam08239 441771004851 Domain of unknown function (DUF4352); Region: DUF4352; pfam11611 441771004852 Bacterial regulatory protein, Fis family; Region: HTH_8; pfam02954 441771004853 Hemerythrin family; Region: Hemerythrin-like; cl15774 441771004854 Fe binding site [ion binding]; other site 441771004855 alanine racemase; Reviewed; Region: alr; PRK00053 441771004856 Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzyme Alanine Racemase; Region: PLPDE_III_AR; cd00430 441771004857 active site 441771004858 pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site 441771004859 dimer interface [polypeptide binding]; other site 441771004860 substrate binding site [chemical binding]; other site 441771004861 catalytic residues [active] 441771004862 Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer); Region: MA; smart00283 441771004863 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cl19050 441771004864 dimer interface [polypeptide binding]; other site 441771004865 putative CheW interface [polypeptide binding]; other site 441771004866 Chemoreceptor zinc-binding domain; Region: CZB; pfam13682 441771004867 Xanthine/uracil/vitamin C permease [Nucleotide transport and metabolism]; Region: COG2252 441771004868 Sulfate transporter family; Region: Sulfate_transp; cl19250 441771004869 Protein of unknown function (DUF975); Region: DUF975; cl10504 441771004870 oxidoreductase; Provisional; Region: PRK06128 441771004871 classical (c) SDR, subgroup 1; Region: SDR_c1; cd05355 441771004872 NAD binding site [chemical binding]; other site 441771004873 metal binding site [ion binding]; metal-binding site 441771004874 active site 441771004875 Cache domain; Region: Cache_1; pfam02743 441771004876 HAMP domain; Region: HAMP; pfam00672 441771004877 Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer); Region: MA; smart00283 441771004878 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 441771004879 dimer interface [polypeptide binding]; other site 441771004880 putative CheW interface [polypeptide binding]; other site 441771004881 WG containing repeat; Region: WG_beta_rep; pfam14903 441771004882 WG containing repeat; Region: WG_beta_rep; pfam14903 441771004883 WG containing repeat; Region: WG_beta_rep; pfam14903 441771004884 WG containing repeat; Region: WG_beta_rep; pfam14903 441771004885 WG containing repeat; Region: WG_beta_rep; pfam14903 441771004886 WG containing repeat; Region: WG_beta_rep; pfam14903 441771004887 WG containing repeat; Region: WG_beta_rep; pfam14903 441771004888 WG containing repeat; Region: WG_beta_rep; pfam14903 441771004889 Bacterial SNF2 helicase associated; Region: SNF2_assoc; pfam08455 441771004890 SNF2 family N-terminal domain; Region: SNF2_N; pfam00176 441771004891 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 441771004892 ATP binding site [chemical binding]; other site 441771004893 putative Mg++ binding site [ion binding]; other site 441771004894 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 441771004895 nucleotide binding region [chemical binding]; other site 441771004896 ATP-binding site [chemical binding]; other site 441771004897 Escherichia coli YaeB and related proteins; Region: UPF0066; cd09281 441771004898 homodimer interaction site [polypeptide binding]; other site 441771004899 cofactor binding site; other site 441771004900 Formylmethanofuran dehydrogenase subunit E [Energy production and conversion]; Region: COG2191 441771004901 FmdE, Molybdenum formylmethanofuran dehydrogenase operon; Region: FmdE; pfam02663 441771004902 Prokaryotic dksA/traR C4-type zinc finger; Region: zf-dskA_traR; pfam01258 441771004903 ABC-type dipeptide transport system, periplasmic component [Amino acid transport and metabolism]; Region: DdpA; COG0747 441771004904 The substrate-binding component of an uncharacterized ABC-type nickel/dipeptide/oligopeptide-like import system contains the type 2 periplasmic binding fold; Region: PBP2_NikA_DppA_OppA_like_21; cd08520 441771004905 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppB; COG0601 441771004906 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 441771004907 dimer interface [polypeptide binding]; other site 441771004908 conserved gate region; other site 441771004909 putative PBP binding loops; other site 441771004910 ABC-ATPase subunit interface; other site 441771004911 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppC; COG1173 441771004912 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 441771004913 dimer interface [polypeptide binding]; other site 441771004914 conserved gate region; other site 441771004915 putative PBP binding loops; other site 441771004916 ABC-ATPase subunit interface; other site 441771004917 ATPase components of various ABC-type transport systems, contain duplicated ATPase [General function prediction only]; Region: COG1123 441771004918 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 441771004919 Walker A/P-loop; other site 441771004920 ATP binding site [chemical binding]; other site 441771004921 Q-loop/lid; other site 441771004922 ABC transporter signature motif; other site 441771004923 Walker B; other site 441771004924 D-loop; other site 441771004925 H-loop/switch region; other site 441771004926 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; pfam08352 441771004927 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 441771004928 Walker A/P-loop; other site 441771004929 ATP binding site [chemical binding]; other site 441771004930 Q-loop/lid; other site 441771004931 ABC transporter signature motif; other site 441771004932 Walker B; other site 441771004933 D-loop; other site 441771004934 H-loop/switch region; other site 441771004935 DEDDh 3'-5' exonuclease domain family; Region: DEDDh; cd06127 441771004936 active site 441771004937 catalytic site [active] 441771004938 substrate binding site [chemical binding]; other site 441771004939 Protein of unknown function (DUF1002); Region: DUF1002; pfam06207 441771004940 Methyltransferase domain; Region: Methyltransf_31; pfam13847 441771004941 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 441771004942 S-adenosylmethionine binding site [chemical binding]; other site 441771004943 Molecular chaperone (small heat shock protein) [Posttranslational modification, protein turnover, chaperones]; Region: IbpA; COG0071 441771004944 Group of bacterial proteins containing an alpha crystallin domain (ACD) similar to Lactobacillus plantarum (Lp) small heat shock proteins (sHsp) HSP 18.5, HSP 18.55 and HSP 19.3. sHsps are molecular chaperones that suppress protein aggregation and...; Region: ACD_LpsHSP_like; cd06471 441771004945 putative dimer interface [polypeptide binding]; other site 441771004946 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 441771004947 Major Facilitator Superfamily; Region: MFS_1; pfam07690 441771004948 putative substrate translocation pore; other site 441771004949 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 441771004950 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 441771004951 1-phosphofructokinase (FruK), minor 6-phosphofructokinase (pfkB) and related sugar kinases. FruK plays an important role in the predominant pathway for fructose utilisation.This group also contains tagatose-6-phophate kinase, an enzyme of the tagatose...; Region: FruK_PfkB_like; cd01164 441771004952 putative substrate binding site [chemical binding]; other site 441771004953 putative ATP binding site [chemical binding]; other site 441771004954 Dipeptide/tripeptide permease [Amino acid transport and metabolism]; Region: PTR2; COG3104 441771004955 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 441771004956 putative substrate translocation pore; other site 441771004957 Putative amidase domain; Region: Amidase_6; pfam12671 441771004958 YeiC-like sugar kinase. Found in eukaryotes and bacteria, YeiC-like kinase is part of the ribokinase/pfkB sugar kinase superfamily. Its oligomerization state is unknown at this time; Region: YeiC_kinase_like; cd01941 441771004959 substrate binding site [chemical binding]; other site 441771004960 ATP binding site [chemical binding]; other site 441771004961 Uncharacterized protein with SCP/PR1 domains [Function unknown]; Region: COG2340 441771004962 Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118 441771004963 SCP_bacterial: SCP-like extracellular protein domain, as found in bacteria and archaea. The wider family of SCP containing proteins includes plant pathogenesis-related protein 1 (PR-1), CRISPs, mammalian cysteine-rich secretory proteins, and allergen 5...; Region: SCP_bacterial; cd05379 441771004964 Cold-Shock Protein (CSP) contains an S1-like cold-shock domain (CSD) that is found in eukaryotes, prokaryotes, and archaea. CSP's include the major cold-shock proteins CspA and CspB in bacteria and the eukaryotic gene regulatory factor Y-box...; Region: CSP_CDS; cd04458 441771004965 DNA-binding site [nucleotide binding]; DNA binding site 441771004966 RNA-binding motif; other site 441771004967 Cache domain; Region: Cache_1; pfam02743 441771004968 Methyl-accepting chemotaxis protein [Cell motility and secretion / Signal transduction mechanisms]; Region: Tar; COG0840 441771004969 HAMP domain; Region: HAMP; pfam00672 441771004970 Haemagglutinin-neuraminidase; Region: HN; pfam00423 441771004971 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cl19050 441771004972 dimer interface [polypeptide binding]; other site 441771004973 putative CheW interface [polypeptide binding]; other site 441771004974 ATPase components of ABC transporters with duplicated ATPase domains [General function prediction only]; Region: Uup; COG0488 441771004975 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 441771004976 ABC transporter; Region: ABC_tran_2; pfam12848 441771004977 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 441771004978 This CD, composed mainly of bacterial single-domain proteins, includes the Thermus thermophilus (Tt) YbaK-like protein, a homolog of the trans-acting Escherichia coli YbaK Cys-tRNA(Pro) deacylase and the Agrobacterium tumefaciens ProX Ala-tRNA(Pro)...; Region: ProX_deacylase; cd04333 441771004979 putative deacylase active site [active] 441771004980 sulfite reductase, subunit C; Region: sulfite_red_C; TIGR02912 441771004981 Nitrite/Sulfite reductase ferredoxin-like half domain; Region: NIR_SIR_ferr; pfam03460 441771004982 Nitrite and sulphite reductase 4Fe-4S domain; Region: NIR_SIR; pfam01077 441771004983 Chemotaxis signal transduction protein [Cell motility and secretion / Signal transduction mechanisms]; Region: CheW; COG0835 441771004984 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 441771004985 active site 441771004986 phosphorylation site [posttranslational modification] 441771004987 intermolecular recognition site; other site 441771004988 dimerization interface [polypeptide binding]; other site 441771004989 ATP-dependent RNA helicase SrmB; Provisional; Region: PRK11192 441771004990 DEAD-box helicases. A diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker B motif; Region: DEADc; cd00268 441771004991 ATP binding site [chemical binding]; other site 441771004992 Mg++ binding site [ion binding]; other site 441771004993 motif III; other site 441771004994 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 441771004995 nucleotide binding region [chemical binding]; other site 441771004996 ATP-binding site [chemical binding]; other site 441771004997 Predicted RNA-bindining protein (contains S1 and HTH domains) [General function prediction only]; Region: COG2996 441771004998 S1 domain; Region: S1_2; pfam13509 441771004999 S1 domain; Region: S1_2; pfam13509 441771005000 Ribosomal protein S1-like RNA-binding domain; Region: S1; smart00316 441771005001 RNA binding site [nucleotide binding]; other site 441771005002 Superfamily II DNA and RNA helicases [DNA replication, recombination, and repair / Transcription / Translation, ribosomal structure and biogenesis]; Region: SrmB; COG0513 441771005003 DEAD-box helicases. A diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker B motif; Region: DEADc; cd00268 441771005004 ATP binding site [chemical binding]; other site 441771005005 Mg++ binding site [ion binding]; other site 441771005006 motif III; other site 441771005007 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 441771005008 nucleotide binding region [chemical binding]; other site 441771005009 ATP-binding site [chemical binding]; other site 441771005010 RNA recognition motif (RRM) superfamily; Region: RRM_SF; cl17169 441771005011 Bacterial Ig-like domain (group 4); Region: Big_4; pfam07532 441771005012 Leucine Rich repeats (2 copies); Region: LRR_4; pfam12799 441771005013 Leucine Rich repeats (2 copies); Region: LRR_4; pfam12799 441771005014 Leucine rich repeat; Region: LRR_8; pfam13855 441771005015 Leucine Rich repeats (2 copies); Region: LRR_4; pfam12799 441771005016 Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 residue sequence motifs present in many proteins that participate in protein-protein interactions and have different functions and cellular locations. LRRs correspond...; Region: LRR_RI; cd00116 441771005017 Leucine Rich repeats (2 copies); Region: LRR_4; pfam12799 441771005018 Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 residue sequence motifs present in many proteins that participate in protein-protein interactions and have different functions and cellular locations. LRRs correspond...; Region: LRR_RI; cd00116 441771005019 Leucine rich repeat; Region: LRR_8; pfam13855 441771005020 Substrate binding site [chemical binding]; other site 441771005021 Leucine rich repeat; Region: LRR_8; pfam13855 441771005022 Leucine rich repeat; Region: LRR_8; pfam13855 441771005023 Leucine Rich repeats (2 copies); Region: LRR_4; pfam12799 441771005024 Leucine Rich repeats (2 copies); Region: LRR_4; pfam12799 441771005025 Leucine rich repeat; Region: LRR_8; pfam13855 441771005026 Leucine Rich repeats (2 copies); Region: LRR_4; pfam12799 441771005027 Bacterial Ig-like domain (group 4); Region: Big_4; pfam07532 441771005028 Beta- N-acetylglucosaminidase [Carbohydrate transport and metabolism]; Region: LytD; COG4193 441771005029 Muramidase (flagellum-specific) [Cell motility and secretion / Intracellular trafficking and secretion]; Region: FlgJ; COG1705 441771005030 nonheme-containing ferritins; Region: Nonheme_Ferritin; cd01055 441771005031 Ferritin-like domain; Region: Ferritin; pfam00210 441771005032 ferroxidase diiron center [ion binding]; other site 441771005033 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 441771005034 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 441771005035 active site 441771005036 phosphorylation site [posttranslational modification] 441771005037 intermolecular recognition site; other site 441771005038 dimerization interface [polypeptide binding]; other site 441771005039 Chemotaxis phosphatase CheX; Region: CheX; pfam13690 441771005040 Predicted inhibitor of MCP methylation, homolog of CheC [Cell motility and secretion]; Region: COG1406 441771005041 Chemotaxis phosphatase CheX; Region: CheX; pfam13690 441771005042 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3314 441771005043 Nucleoside recognition; Region: Gate; pfam07670 441771005044 Small, acid-soluble spore proteins, alpha/beta type; Region: SASP; pfam00269 441771005045 Small, acid-soluble spore proteins, alpha/beta type; Region: SASP; pfam00269 441771005046 Iron-sulphur cluster biosynthesis; Region: Fe-S_biosyn; cl00400 441771005047 site-specific tyrosine recombinase XerC; Reviewed; Region: xerC; PRK00236 441771005048 DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213 441771005049 active site 441771005050 DNA binding site [nucleotide binding] 441771005051 Int/Topo IB signature motif; other site 441771005052 Autophagy protein Apg6; Region: APG6; pfam04111 441771005053 LexA repressor; Validated; Region: PRK00215 441771005054 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 441771005055 putative Zn2+ binding site [ion binding]; other site 441771005056 putative DNA binding site [nucleotide binding]; other site 441771005057 Peptidase S24 LexA-like proteins are involved in the SOS response leading to the repair of single-stranded DNA within the bacterial cell. This family includes: the lambda repressor CI/C2 family and related bacterial prophage repressor proteins; LexA (EC...; Region: S24_LexA-like; cd06529 441771005058 Catalytic site [active] 441771005059 Methionine gamma-lyase; Region: Met_gamma_lyase; pfam06838 441771005060 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 441771005061 catalytic residue [active] 441771005062 bacterial Hfq-like; Region: Hfq; cd01716 441771005063 hexamer interface [polypeptide binding]; other site 441771005064 Sm1 motif; other site 441771005065 RNA binding site [nucleotide binding]; other site 441771005066 Sm2 motif; other site 441771005067 tRNA delta(2)-isopentenylpyrophosphate transferase; Reviewed; Region: miaA; PRK00091 441771005068 DNA mismatch repair protein; Reviewed; Region: mutL; PRK00095 441771005069 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 441771005070 ATP binding site [chemical binding]; other site 441771005071 Mg2+ binding site [ion binding]; other site 441771005072 G-X-G motif; other site 441771005073 MutL_Trans: transducer domain, having a ribosomal S5 domain 2-like fold, conserved in the C-terminal domain of DNA mismatch repair (MutL/MLH1/PMS2) family. This transducer domain is homologous to the second domain of the DNA gyrase B subunit, which is...; Region: MutL_Trans; cd00782 441771005074 ATP binding site [chemical binding]; other site 441771005075 MutL C terminal dimerisation domain; Region: MutL_C; smart00853 441771005076 (dimethylallyl)adenosine tRNA methylthiotransferase; Provisional; Region: PRK14328 441771005077 Uncharacterized protein family UPF0004; Region: UPF0004; pfam00919 441771005078 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 441771005079 FeS/SAM binding site; other site 441771005080 TRAM domain; Region: TRAM; pfam01938 441771005081 Aspartate/tyrosine/aromatic aminotransferase [Amino acid transport and metabolism]; Region: COG0436 441771005082 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 441771005083 pyridoxal 5'-phosphate binding site [chemical binding]; other site 441771005084 homodimer interface [polypeptide binding]; other site 441771005085 catalytic residue [active] 441771005086 aspartate aminotransferase; Provisional; Region: PRK07568 441771005087 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 441771005088 pyridoxal 5'-phosphate binding site [chemical binding]; other site 441771005089 homodimer interface [polypeptide binding]; other site 441771005090 catalytic residue [active] 441771005091 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 441771005092 Coenzyme A binding pocket [chemical binding]; other site 441771005093 Aminoglycoside 3'-phosphotransferase (APH) and Choline Kinase (ChoK) family. The APH/ChoK family is part of a larger superfamily that includes the catalytic domains of other kinases, such as the typical serine/threonine/tyrosine protein kinases (PKs)...; Region: APH_ChoK_like; cl17270 441771005094 4-hydroxy-3-methylbut-2-enyl diphosphate reductase/S1 RNA-binding domain protein; Reviewed; Region: PRK00087 441771005095 4-hydroxy-3-methylbut-2-enyl diphosphate reductase; Region: lytB_ispH; cd13944 441771005096 Fe-S cluster binding site [ion binding]; other site 441771005097 substrate binding site [chemical binding]; other site 441771005098 catalytic site [active] 441771005099 S1_RPS1_repeat_ec1_hs1: Ribosomal protein S1 (RPS1) domain. RPS1 is a component of the small ribosomal subunit thought to be involved in the recognition and binding of mRNA's during translation initiation. The bacterial RPS1 domain architecture...; Region: S1_RPS1_repeat_ec1_hs1; cd05687 441771005100 RNA binding site [nucleotide binding]; other site 441771005101 S1_RPS1_repeat_ec2_hs2: Ribosomal protein S1 (RPS1) domain. RPS1 is a component of the small ribosomal subunit thought to be involved in the recognition and binding of mRNA's during translation initiation. The bacterial RPS1 domain architecture...; Region: S1_RPS1_repeat_ec2_hs2; cd04465 441771005102 RNA binding site [nucleotide binding]; other site 441771005103 S1_RPS1_repeat_ec3: Ribosomal protein S1 (RPS1) domain. RPS1 is a component of the small ribosomal subunit thought to be involved in the recognition and binding of mRNA's during translation initiation. The bacterial RPS1 domain architecture consists...; Region: S1_RPS1_repeat_ec3; cd05688 441771005104 RNA binding site [nucleotide binding]; other site 441771005105 S1 RNA binding domain; Region: S1; pfam00575 441771005106 RNA binding site [nucleotide binding]; other site 441771005107 cytidylate kinase; Provisional; Region: cmk; PRK00023 441771005108 Cytidine monophosphate kinase (CMPK) catalyzes the reversible phosphorylation of cytidine monophosphate (CMP) to produce cytidine diphosphate (CDP), using ATP as the preferred phosphoryl donor; Region: CMPK; cd02020 441771005109 AAA domain; Region: AAA_17; cl19128 441771005110 CMP-binding site; other site 441771005111 The sites determining sugar specificity; other site 441771005112 Chorismate mutase (AroH) is one of at least five chorismate-utilizing enzymes present in microorganisms that catalyze the rearrangement of chorismate to prephenic acid, the first committed step in the biosynthesis of aromatic amino acids. In prokaryotes; Region: AroH; cd02185 441771005113 homotrimer interaction site [polypeptide binding]; other site 441771005114 active site 441771005115 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl19134 441771005116 flavoprotein, HI0933 family; Region: TIGR00275 441771005117 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl19134 441771005118 Glutamate dehydrogenase/leucine dehydrogenase [Amino acid transport and metabolism]; Region: GdhA; COG0334 441771005119 Glu/Leu/Phe/Val dehydrogenase, dimerization domain; Region: ELFV_dehydrog_N; pfam02812 441771005120 NAD(P) binding domain of glutamate dehydrogenase, subgroup 1; Region: NAD_bind_1_Glu_DH; cd01076 441771005121 NAD(P) binding site [chemical binding]; other site 441771005122 Transcriptional regulators [Transcription]; Region: RpiR; COG1737 441771005123 Helix-turn-helix domain, rpiR family; Region: HTH_6; pfam01418 441771005124 RpiR-like protein. RpiR contains a SIS (Sugar ISomerase) domain, which is found in many phosphosugar isomerases and phosphosugar binding proteins. In E. coli, rpiR negatively regulates the expression of rpiB gene. Both rpiB and rpiA are ribose phosphate...; Region: SIS_RpiR; cd05013 441771005125 putative active site [active] 441771005126 16S rRNA uridine-516 pseudouridylate synthase and related pseudouridylate synthases [Translation, ribosomal structure and biogenesis]; Region: RsuA; COG1187 441771005127 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 441771005128 RNA binding surface [nucleotide binding]; other site 441771005129 Pseudouridine synthases, RsuA subfamily; Region: PseudoU_synth_RsuA_like; cd02870 441771005130 active site 441771005131 Domain of unknown function (DUF2088); Region: DUF2088; pfam09861 441771005132 L-cysteine desulfidase [Amino acid transport and metabolism]; Region: COG3681 441771005133 Glycosyltransferases, probably involved in cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: COG1215 441771005134 EpsO protein participates in the methanolan synthesis; Region: EpsO_like; cd06438 441771005135 DXD motif; other site 441771005136 Dolichyl-phosphate-mannose-protein mannosyltransferase; Region: PMT_2; cl19158 441771005137 Ribbon-helix-helix protein, copG family; Region: RHH_1; pfam01402 441771005138 Sensory domain of two-component sensor kinase; Region: Cache_3; pfam14827 441771005139 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 441771005140 dimerization interface [polypeptide binding]; other site 441771005141 Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer); Region: MA; smart00283 441771005142 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 441771005143 dimer interface [polypeptide binding]; other site 441771005144 putative CheW interface [polypeptide binding]; other site 441771005145 Cytochrome c biogenesis protein [Posttranslational modification, protein turnover, chaperones]; Region: CcdA; COG0785 441771005146 TRX family; composed of two groups: Group I, which includes proteins that exclusively encode a TRX domain; and Group II, which are composed of fusion proteins of TRX and additional domains. Group I TRX is a small ancient protein that alter the redox...; Region: TRX_family; cd02947 441771005147 catalytic residues [active] 441771005148 Nit1, Nit 2, and related proteins, and the Nit1-like domain of NitFhit (class 10 nitrilases); Region: nit; cd07572 441771005149 putative active site [active] 441771005150 catalytic triad [active] 441771005151 dimer interface [polypeptide binding]; other site 441771005152 Sodium/hydrogen exchanger family; Region: Na_H_Exchanger; pfam00999 441771005153 TrkA-C domain; Region: TrkA_C; pfam02080 441771005154 Uncharacterized homolog of gamma-carboxymuconolactone decarboxylase subunit [Function unknown]; Region: COG0599 441771005155 Acetyltransferases, including N-acetylases of ribosomal proteins [Translation, ribosomal structure and biogenesis]; Region: RimL; COG1670 441771005156 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 441771005157 Coenzyme A binding pocket [chemical binding]; other site 441771005158 Rhodanese Homology Domain (RHOD); an alpha beta fold domain found duplicated in the rhodanese protein. The cysteine containing enzymatically active version of the domain is also found in the Cdc25 class of protein phosphatases and a variety of proteins...; Region: RHOD; cd00158 441771005159 active site residue [active] 441771005160 Putative heavy-metal-binding; Region: YbjQ_1; pfam01906 441771005161 Thioredoxin (TRX)-like [2Fe-2S] Ferredoxin (Fd) family; composed of [2Fe-2S] Fds with a TRX fold (TRX-like Fds) and proteins containing domains similar to TRX-like Fd including formate dehydrogenases, NAD-reducing hydrogenases and the subunit E of NADH:...; Region: TRX_Fd_family; cd02980 441771005162 dimer interface [polypeptide binding]; other site 441771005163 [2Fe-2S] cluster binding site [ion binding]; other site 441771005164 [FeFe] hydrogenase, group A; Region: FeFe_hydrog_A; TIGR02512 441771005165 4Fe-4S double cluster binding domain; Region: Fer4_16; pfam13484 441771005166 Iron only hydrogenase large subunit, C-terminal domain; Region: Fe_hyd_lg_C; pfam02906 441771005167 Putative Fe-S cluster; Region: FeS; cl17515 441771005168 PAS domain; Region: PAS_9; pfam13426 441771005169 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 441771005170 putative active site [active] 441771005171 heme pocket [chemical binding]; other site 441771005172 Stage II sporulation protein E (SpoIIE); Region: SpoIIE; pfam07228 441771005173 [FeFe] hydrogenase, group A; Region: FeFe_hydrog_A; TIGR02512 441771005174 4Fe-4S double cluster binding domain; Region: Fer4_16; pfam13484 441771005175 Iron only hydrogenase large subunit, C-terminal domain; Region: Fe_hyd_lg_C; pfam02906 441771005176 Putative Fe-S cluster; Region: FeS; cl17515 441771005177 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 441771005178 putative active site [active] 441771005179 HypE (Hydrogenase expression/formation protein). HypE is involved in Ni-Fe hydrogenase biosynthesis. HypE dehydrates its own carbamoyl moiety in an ATP-dependent process to yield the enzyme thiocyanate. The N-terminal domain of HypE is related to the...; Region: HypE; cd02197 441771005180 dimerization interface [polypeptide binding]; other site 441771005181 hydrogenase expression/formation protein HypE; Region: hypE; TIGR02124 441771005182 ATP binding site [chemical binding]; other site 441771005183 Hydrogenase formation hypA family; Region: HypD; pfam01924 441771005184 HupF/HypC family; Region: HupF_HypC; pfam01455 441771005185 Acylphosphatase; Region: Acylphosphatase; pfam00708 441771005186 Hydrogenase maturation factor [Posttranslational modification, protein turnover, chaperones]; Region: HypF; COG0068 441771005187 HypF finger; Region: zf-HYPF; pfam07503 441771005188 HypF finger; Region: zf-HYPF; pfam07503 441771005189 Telomere recombination; Region: Sua5_yciO_yrdC; pfam01300 441771005190 Cytochrome b5-like Heme/Steroid binding domain; Region: Cyt-b5; cl02041 441771005191 Hydrogenase specific C-terminal endopeptidases, also called Hydrogen Maturation Proteases (H2MP). These enzymes belong to the peptidase family M52. Maturation of [FeNi] hydrogenases includes formation of the nickel metallocenter, proteolytic processing...; Region: H2MP; cd00518 441771005192 nickel binding site [ion binding]; other site 441771005193 Ni,Fe-hydrogenase I large subunit [Energy production and conversion]; Region: HyaB; COG0374 441771005194 Ni,Fe-hydrogenase III large subunit [Energy production and conversion]; Region: HycE; COG3261 441771005195 Ni,Fe-hydrogenase I small subunit [Energy production and conversion]; Region: HyaA; COG1740 441771005196 NADH ubiquinone oxidoreductase, 20 Kd subunit; Region: Oxidored_q6; pfam01058 441771005197 NiFe/NiFeSe hydrogenase small subunit C-terminal; Region: NiFe_hyd_SSU_C; pfam14720 441771005198 TraX protein; Region: TraX; cl05434 441771005199 Protein of unknown function (DUF1043); Region: DUF1043; cl11473 441771005200 ATPase components of ABC transporters with duplicated ATPase domains [General function prediction only]; Region: Uup; COG0488 441771005201 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 441771005202 ABC transporter; Region: ABC_tran_2; pfam12848 441771005203 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 441771005204 bidirectional hydrogenase complex protein HoxU; Validated; Region: PRK07569 441771005205 2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207 441771005206 catalytic loop [active] 441771005207 iron binding site [ion binding]; other site 441771005208 NADH-ubiquinone oxidoreductase-G iron-sulfur binding region; Region: NADH-G_4Fe-4S_3; pfam10588 441771005209 [FeFe] hydrogenase, group A; Region: FeFe_hydrog_A; TIGR02512 441771005210 4Fe-4S dicluster domain; Region: Fer4_8; pfam13183 441771005211 Iron only hydrogenase large subunit, C-terminal domain; Region: Fe_hyd_lg_C; pfam02906 441771005212 Iron hydrogenase small subunit; Region: Fe_hyd_SSU; pfam02256 441771005213 Thioredoxin (TRX)-like [2Fe-2S] Ferredoxin (Fd) family; composed of [2Fe-2S] Fds with a TRX fold (TRX-like Fds) and proteins containing domains similar to TRX-like Fd including formate dehydrogenases, NAD-reducing hydrogenases and the subunit E of NADH:...; Region: TRX_Fd_family; cd02980 441771005214 dimer interface [polypeptide binding]; other site 441771005215 [2Fe-2S] cluster binding site [ion binding]; other site 441771005216 NADH:ubiquinone oxidoreductase, NADH-binding (51 kD) subunit [Energy production and conversion]; Region: NuoF; COG1894 441771005217 Respiratory-chain NADH dehydrogenase 51 Kd subunit; Region: Complex1_51K; pfam01512 441771005218 SLBB domain; Region: SLBB; pfam10531 441771005219 NADH-ubiquinone oxidoreductase-F iron-sulfur binding region; Region: NADH_4Fe-4S; pfam10589 441771005220 The HCP family of iron-sulfur proteins includes hybrid cluster protein (HCP), acetyl-CoA synthase (ACS), and carbon monoxide dehydrogenase (CODH), all of which contain [Fe4-S4] metal clusters at their active sites. These proteins have a conserved...; Region: HCP_like; cl19102 441771005221 4Fe-4S dicluster domain; Region: Fer4_9; pfam13187 441771005222 Thioredoxin-like [2Fe-2S] ferredoxin; Region: 2Fe-2S_thioredx; pfam01257 441771005223 TRX-like [2Fe-2S] Ferredoxin (Fd) family, NADH:ubiquinone oxidoreductase (Nuo) subunit E subfamily; Nuo, also called respiratory chain Complex 1, is the entry point for electrons into the respiratory chains of bacteria and the mitochondria of eukaryotes; Region: TRX_Fd_NuoE; cd03064 441771005224 putative dimer interface [polypeptide binding]; other site 441771005225 [2Fe-2S] cluster binding site [ion binding]; other site 441771005226 Transmembrane subunit (TM) of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which are involved in the uptake of branched-chain amino acids (AAs), as well as TMs of transporters involved in the uptake of...; Region: TM_PBP1_branched-chain-AA_like; cl00454 441771005227 ADP-ribosylglycohydrolase; Region: ADP_ribosyl_GH; pfam03747 441771005228 Predicted permease, member of the PurR regulon [General function prediction only]; Region: yhhT; COG0628 441771005229 D-alanyl-D-alanine carboxypeptidase [Cell envelope biogenesis, outer membrane]; Region: DacC; COG1686 441771005230 Beta-lactamase enzyme family; Region: Beta-lactamase2; cl19191 441771005231 Penicillin-binding protein 5, C-terminal domain; Region: PBP5_C; smart00936 441771005232 Protein of unknown function (DUF2953); Region: DUF2953; pfam11167 441771005233 sporulation protein YtfJ; Region: spore_ytfJ; TIGR02874 441771005234 segregation and condensation protein B; Reviewed; Region: scpB; PRK00135 441771005235 segregation and condensation protein A; Reviewed; Region: scpA; PRK00104 441771005236 D-alanyl-D-alanine carboxypeptidase [Cell envelope biogenesis, outer membrane]; Region: DacC; COG1686 441771005237 Beta-lactamase enzyme family; Region: Beta-lactamase2; cl19191 441771005238 Penicillin-binding protein 5, C-terminal domain; Region: PBP5_C; smart00936 441771005239 EcsC protein family; Region: EcsC; pfam12787 441771005240 Exonuclease-Endonuclease-Phosphatase (EEP) domain superfamily; Region: EEP; cl00490 441771005241 putative catalytic site [active] 441771005242 putative metal binding site [ion binding]; other site 441771005243 Exonuclease-Endonuclease-Phosphatase (EEP) domain superfamily; Region: EEP; cl00490 441771005244 putative catalytic site [active] 441771005245 putative phosphate binding site [ion binding]; other site 441771005246 putative phosphate binding site [ion binding]; other site 441771005247 putative metal binding site [ion binding]; other site 441771005248 pyrimidine-nucleoside phosphorylase; Reviewed; Region: PRK06078 441771005249 Glycosyl transferase family, helical bundle domain; Region: Glycos_trans_3N; pfam02885 441771005250 Glycosyl transferase family, a/b domain; Region: Glycos_transf_3; pfam00591 441771005251 Pyrimidine nucleoside phosphorylase C-terminal domain; Region: PYNP_C; smart00941 441771005252 purine nucleoside phosphorylase; Provisional; Region: PRK08202 441771005253 Purine nucleoside phosphorylase [Nucleotide transport and metabolism]; Region: Pnp; COG0005 441771005254 XerD and XerC integrases, DNA breaking-rejoining enzymes, N- and C-terminal domains. XerD-like integrases are involved in the site-specific integration and excision of lysogenic bacteriophage genomes, transposition of conjugative transposons, termination...; Region: INT_XerDC; cd00798 441771005255 tyrosine recombinase XerD; Region: recomb_XerD; TIGR02225 441771005256 active site 441771005257 Int/Topo IB signature motif; other site 441771005258 stage II sporulation protein M; Region: spo_II_M; TIGR02831 441771005259 nudix-type nucleoside diphosphatase, YffH/AdpP family; Region: TIGR00052 441771005260 ADP-ribose pyrophosphatase (ADPRase) catalyzes the hydrolysis of ADP-ribose and a variety of additional ADP-sugar conjugates to AMP and ribose-5-phosphate. Like other members of the Nudix hydrolase superfamily, it requires a divalent cation, such as Mg2+; Region: ADPRase_NUDT5; cd03424 441771005261 dimer interface [polypeptide binding]; other site 441771005262 ADP-ribose binding site [chemical binding]; other site 441771005263 active site 441771005264 nudix motif; other site 441771005265 metal binding site [ion binding]; metal-binding site 441771005266 inner membrane transporter YjeM; Provisional; Region: PRK15238 441771005267 Cell wall-associated hydrolases (invasion-associated proteins) [Cell envelope biogenesis, outer membrane]; Region: Spr; COG0791 441771005268 NlpC/P60 family; Region: NLPC_P60; pfam00877 441771005269 DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213 441771005270 sporulation transcription factor Spo0A; Region: spore_0_A; TIGR02875 441771005271 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 441771005272 active site 441771005273 phosphorylation site [posttranslational modification] 441771005274 intermolecular recognition site; other site 441771005275 dimerization interface [polypeptide binding]; other site 441771005276 Sporulation initiation factor Spo0A C terminal; Region: Spo0A_C; pfam08769 441771005277 stage IV sporulation protein B; Region: spore_IV_B; TIGR02860 441771005278 PDZ domain of bacterial and plant zinc metalloprotases, presumably membrane-associated or integral membrane proteases, which may be involved in signalling and regulatory mechanisms. May be responsible for substrate recognition and/or binding, as most PDZ...; Region: PDZ_metalloprotease; cd00989 441771005279 SpoIVB peptidase S55; Region: Peptidase_S55; pfam05580 441771005280 Type 1 glutamine amidotransferase (GATase1)-like domain found in homoserine trans-succinylase (HTS); Region: GATase1_HTS; cd03131 441771005281 proposed active site lysine [active] 441771005282 conserved cys residue [active] 441771005283 Homoserine dehydrogenase [Amino acid transport and metabolism]; Region: ThrA; COG0460 441771005284 Homoserine dehydrogenase, NAD binding domain; Region: NAD_binding_3; pfam03447 441771005285 Homoserine dehydrogenase; Region: Homoserine_dh; pfam00742 441771005286 CGS_like: Cystathionine gamma-synthase is a PLP dependent enzyme and catalyzes the committed step of methionine biosynthesis. This pathway is unique to microorganisms and plants, rendering the enzyme an attractive target for the development of...; Region: CGS_like; cd00614 441771005287 homodimer interface [polypeptide binding]; other site 441771005288 substrate-cofactor binding pocket; other site 441771005289 pyridoxal 5'-phosphate binding site [chemical binding]; other site 441771005290 catalytic residue [active] 441771005291 ATPase involved in DNA repair [DNA replication, recombination, and repair]; Region: RecN; COG0497 441771005292 ATP-binding cassette domain of RecN; Region: ABC_RecN; cd03241 441771005293 Walker A/P-loop; other site 441771005294 ATP binding site [chemical binding]; other site 441771005295 Q-loop/lid; other site 441771005296 ATP-binding cassette domain of RecN; Region: ABC_RecN; cd03241 441771005297 ABC transporter signature motif; other site 441771005298 Walker B; other site 441771005299 D-loop; other site 441771005300 H-loop/switch region; other site 441771005301 arginine repressor; Provisional; Region: argR; PRK00441 441771005302 Arginine repressor, DNA binding domain; Region: Arg_repressor; pfam01316 441771005303 Arginine repressor, C-terminal domain; Region: Arg_repressor_C; pfam02863 441771005304 NAD kinase [Coenzyme metabolism]; Region: nadF; COG0061 441771005305 Predicted rRNA methylase [Translation, ribosomal structure and biogenesis]; Region: COG1189 441771005306 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 441771005307 RNA binding surface [nucleotide binding]; other site 441771005308 FtsJ-like methyltransferase; Region: FtsJ; pfam01728 441771005309 1-deoxy-D-xylulose-5-phosphate synthase; Provisional; Region: PRK05444 441771005310 Thiamine pyrophosphate (TPP) family, DXS subfamily, TPP-binding module; 1-Deoxy-D-xylulose-5-phosphate synthase (DXS) is a regulatory enzyme of the mevalonate-independent pathway involved in terpenoid biosynthesis. Terpeniods are plant natural products...; Region: TPP_DXS; cd02007 441771005311 TPP-binding site; other site 441771005312 Pyrimidine (PYR) binding domain of 1-deoxy-D-xylulose-5-phosphate synthase (DXS), transketolase (TK), and related proteins; Region: TPP_PYR_DXS_TK_like; cd07033 441771005313 PYR/PP interface [polypeptide binding]; other site 441771005314 dimer interface [polypeptide binding]; other site 441771005315 TPP binding site [chemical binding]; other site 441771005316 Transketolase, C-terminal domain; Region: Transketolase_C; pfam02780 441771005317 Trans-Isoprenyl Diphosphate Synthases, head-to-tail; Region: Trans_IPPS_HT; cd00685 441771005318 substrate binding pocket [chemical binding]; other site 441771005319 chain length determination region; other site 441771005320 substrate-Mg2+ binding site; other site 441771005321 catalytic residues [active] 441771005322 aspartate-rich region 1; other site 441771005323 active site lid residues [active] 441771005324 aspartate-rich region 2; other site 441771005325 exodeoxyribonuclease VII small subunit; Provisional; Region: PRK00977 441771005326 exodeoxyribonuclease VII large subunit; Reviewed; Region: xseA; PRK00286 441771005327 ExoVII_LU_OBF: A subfamily of OB folds corresponding to the N-terminal OB-fold domain of Escherichia coli exodeoxyribonuclease VII (ExoVII) large subunit. E. coli ExoVII is composed of two non-identical subunits. E. coli ExoVII is a...; Region: ExoVII_LU_OBF; cd04489 441771005328 generic binding surface I; other site 441771005329 generic binding surface II; other site 441771005330 transcription antitermination protein NusB; Reviewed; Region: nusB; PRK00202 441771005331 putative RNA binding site [nucleotide binding]; other site 441771005332 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG1302 441771005333 SpoIIIAH-like protein; Region: SpoIIIAH; pfam12685 441771005334 stage III sporulation protein AG; Region: spore_III_AG; TIGR02830 441771005335 Stage III sporulation protein AF (Spore_III_AF); Region: Spore_III_AF; pfam09581 441771005336 stage III sporulation protein AE; Region: spore_III_AE; TIGR02829 441771005337 stage III sporulation protein AD; Region: spore_III_AD; TIGR02849 441771005338 stage III sporulation protein AC; Region: spore_III_AC; TIGR02848 441771005339 stage III sporulation protein SpoAB; Provisional; Region: PRK08307 441771005340 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cl18944 441771005341 stage III sporulation protein AA; Region: spore_III_AA; TIGR02858 441771005342 elongation factor P; Validated; Region: PRK00529 441771005343 Elongation factor P (EF-P) KOW-like domain; Region: EFP_N; pfam08207 441771005344 S1_EF-P_repeat_1: Translation elongation factor P (EF-P), S1-like RNA-binding domain, repeat 1. EF-P stimulates the peptidyltransferase activity in the prokaryotic 70S ribosome. EF-P enhances the synthesis of certain dipeptides with...; Region: S1_EF-P_repeat_1; cd04470 441771005345 RNA binding site [nucleotide binding]; other site 441771005346 S1_EF-P_repeat_2: Translation elongation factor P (EF-P), S1-like RNA-binding domain, repeat 1. EF-P stimulates the peptidyltransferase activity in the prokaryotic 70S ribosome. EF-P enhances the synthesis of certain dipeptides with...; Region: S1_EF-P_repeat_2; cd05794 441771005347 RNA binding site [nucleotide binding]; other site 441771005348 Dehydroquinase (DHQase), type II. Dehydroquinase (or 3-dehydroquinate dehydratase) catalyzes the reversible dehydration of 3-dehydroquinate to form 3-dehydroshikimate. This reaction is part of two metabolic pathways: the biosynthetic shikimate pathway...; Region: DHQase_II; cd00466 441771005349 trimer interface [polypeptide binding]; other site 441771005350 active site 441771005351 dimer interface [polypeptide binding]; other site 441771005352 Shikimate kinase [Amino acid transport and metabolism]; Region: AroK; COG0703 441771005353 Shikimate kinase (SK) is the fifth enzyme in the shikimate pathway, a seven-step biosynthetic pathway which converts erythrose-4-phosphate to chorismic acid, found in bacteria, fungi and plants. Chorismic acid is a important intermediate in the synthesis...; Region: SK; cd00464 441771005354 ADP binding site [chemical binding]; other site 441771005355 magnesium binding site [ion binding]; other site 441771005356 putative shikimate binding site; other site 441771005357 Type II secretory pathway, pseudopilin PulG [Cell motility and secretion / Intracellular trafficking and secretion]; Region: PulG; COG2165 441771005358 Type IV pilin N-term methylation site GFxxxE; Region: N_methyl_2; pfam13544 441771005359 Type II secretory pathway, pseudopilin PulG [Cell motility and secretion / Intracellular trafficking and secretion]; Region: PulG; COG2165 441771005360 Type II secretory pathway, pseudopilin PulG [Cell motility and secretion / Intracellular trafficking and secretion]; Region: PulG; COG2165 441771005361 Type IV pilin N-term methylation site GFxxxE; Region: N_methyl_2; pfam13544 441771005362 Type II secretory pathway, component PulF [Cell motility and secretion / Intracellular trafficking and secretion]; Region: PulF; COG1459 441771005363 Type II secretion system (T2SS), protein F; Region: T2SF; pfam00482 441771005364 Type II secretion system (T2SS), protein F; Region: T2SF; pfam00482 441771005365 Type II secretory pathway, ATPase PulE/Tfp pilus assembly pathway, ATPase PilB [Cell motility and secretion / Intracellular trafficking and secretion]; Region: PulE; COG2804 441771005366 Type II secretion system (T2SS), protein E, N-terminal domain; Region: T2SE_Nter; pfam05157 441771005367 PulE/GspE The type II secretory pathway is the main terminal branch of the general secretory pathway (GSP). It is responsible for the export the majority of Gram-negative bacterial exoenzymes and toxins. PulE is a cytoplasmic protein of the GSP, which...; Region: PulE-GspE; cd01129 441771005368 Walker A motif; other site 441771005369 ATP binding site [chemical binding]; other site 441771005370 Walker B motif; other site 441771005371 Phytase; Region: Phytase; cl17685 441771005372 diaminopimelate epimerase; Provisional; Region: dapF; PRK00450 441771005373 Diaminopimelate epimerase; Region: DAP_epimerase; pfam01678 441771005374 Diaminopimelate epimerase; Region: DAP_epimerase; pfam01678 441771005375 Fibronectin-binding protein A N-terminus (FbpA); Region: FbpA; pfam05833 441771005376 Domain of unknown function (DUF814); Region: DUF814; pfam05670 441771005377 tRNA pseudouridine synthase A; Reviewed; Region: PRK12434 441771005378 Eukaryotic and bacterial pseudouridine synthases similar to E. coli TruA; Region: PseudoU_synth_EcTruA; cd02570 441771005379 dimerization interface 3.5A [polypeptide binding]; other site 441771005380 active site 441771005381 Diadenosine tetraphosphate (Ap4A) hydrolase and other HIT family hydrolases [Nucleotide transport and metabolism / Carbohydrate transport and metabolism / General function prediction only]; Region: Hit; COG0537 441771005382 nucleotide binding site/active site [active] 441771005383 HIT family signature motif; other site 441771005384 catalytic residue [active] 441771005385 DOPA decarboxylase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to DOPA/tyrosine decarboxylase (DDC), histidine decarboxylase (HDC), and...; Region: DOPA_deC_like; cd06450 441771005386 pyridoxal 5'-phosphate binding site [chemical binding]; other site 441771005387 catalytic residue [active] 441771005388 ligand binding domain of Tar- and Tsr-related chemoreceptors; Region: Tar_Tsr_LBD; cl00144 441771005389 Methyl-accepting chemotaxis protein [Cell motility and secretion / Signal transduction mechanisms]; Region: Tar; COG0840 441771005390 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 441771005391 dimerization interface [polypeptide binding]; other site 441771005392 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cl19050 441771005393 dimer interface [polypeptide binding]; other site 441771005394 putative CheW interface [polypeptide binding]; other site 441771005395 clostripain; Region: clostrip; TIGR02806 441771005396 M14 family of metallocarboxypeptidases and related proteins; Region: Peptidase_M14_like; cl11393 441771005397 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 441771005398 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 441771005399 active site 441771005400 phosphorylation site [posttranslational modification] 441771005401 intermolecular recognition site; other site 441771005402 dimerization interface [polypeptide binding]; other site 441771005403 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 441771005404 DNA binding site [nucleotide binding] 441771005405 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 441771005406 VIP2; A family of actin-ADP-ribosylating toxin. A member of the Bacillus-prodiced vegetative insecticidal proteins (VIPs) possesses high specificity against the major insect pest, corn rootworms, and belongs to a classs of binary toxins and regulators of...; Region: VIP2; cl00173 441771005407 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 441771005408 dimer interface [polypeptide binding]; other site 441771005409 phosphorylation site [posttranslational modification] 441771005410 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 441771005411 ATP binding site [chemical binding]; other site 441771005412 Mg2+ binding site [ion binding]; other site 441771005413 G-X-G motif; other site 441771005414 methionine sulfoxide reductase A; Provisional; Region: PRK14054 441771005415 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 441771005416 active site 441771005417 phosphorylation site [posttranslational modification] 441771005418 intermolecular recognition site; other site 441771005419 dimerization interface [polypeptide binding]; other site 441771005420 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 441771005421 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 441771005422 active site 441771005423 phosphorylation site [posttranslational modification] 441771005424 intermolecular recognition site; other site 441771005425 dimerization interface [polypeptide binding]; other site 441771005426 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 441771005427 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 441771005428 dimerization interface [polypeptide binding]; other site 441771005429 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 441771005430 dimer interface [polypeptide binding]; other site 441771005431 phosphorylation site [posttranslational modification] 441771005432 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 441771005433 ATP binding site [chemical binding]; other site 441771005434 Mg2+ binding site [ion binding]; other site 441771005435 G-X-G motif; other site 441771005436 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 441771005437 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 441771005438 active site 441771005439 phosphorylation site [posttranslational modification] 441771005440 intermolecular recognition site; other site 441771005441 dimerization interface [polypeptide binding]; other site 441771005442 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 441771005443 DNA binding site [nucleotide binding] 441771005444 ABC-2 family transporter protein; Region: ABC2_membrane_4; pfam12730 441771005445 ABC-2 family transporter protein; Region: ABC2_membrane_4; pfam12730 441771005446 gallidermin-class lantibiotic protection ABC transporter, ATP-binding subunit; Region: galliderm_ABC; TIGR03740 441771005447 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 441771005448 Walker A/P-loop; other site 441771005449 ATP binding site [chemical binding]; other site 441771005450 Q-loop/lid; other site 441771005451 ABC transporter signature motif; other site 441771005452 Walker B; other site 441771005453 D-loop; other site 441771005454 H-loop/switch region; other site 441771005455 ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132 441771005456 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 441771005457 ATP-binding cassette domain of glucan transporter and related proteins, subfamily C; Region: ABCC_Glucan_exporter_like; cd03254 441771005458 Walker A/P-loop; other site 441771005459 ATP binding site [chemical binding]; other site 441771005460 Q-loop/lid; other site 441771005461 ABC transporter signature motif; other site 441771005462 Walker B; other site 441771005463 D-loop; other site 441771005464 H-loop/switch region; other site 441771005465 ABC transporter, permease/ATP-binding protein; Region: MsbA_rel; TIGR02204 441771005466 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 441771005467 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 441771005468 Walker A/P-loop; other site 441771005469 ATP binding site [chemical binding]; other site 441771005470 Q-loop/lid; other site 441771005471 ABC transporter signature motif; other site 441771005472 Walker B; other site 441771005473 D-loop; other site 441771005474 H-loop/switch region; other site 441771005475 Transcriptional regulators [Transcription]; Region: MarR; COG1846 441771005476 helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347 441771005477 putative Zn2+ binding site [ion binding]; other site 441771005478 putative DNA binding site [nucleotide binding]; other site 441771005479 hypothetical protein; Provisional; Region: PRK08328 441771005480 ThiF_MoeB_HesA. Family of E1-like enzymes involved in molybdopterin and thiamine biosynthesis family. The common reaction mechanism catalyzed by MoeB and ThiF, like other E1 enzymes, begins with a nucleophilic attack of the C-terminal carboxylate of MoaD...; Region: ThiF_MoeB_HesA_family; cd00757 441771005481 ATP binding site [chemical binding]; other site 441771005482 substrate interface [chemical binding]; other site 441771005483 Ubiquitin domain of MoaD-like proteins; Region: MoaD; cd00754 441771005484 MoaE interaction surface [polypeptide binding]; other site 441771005485 MoeB interaction surface [polypeptide binding]; other site 441771005486 thiocarboxylated glycine; other site 441771005487 Aldehyde:ferredoxin oxidoreductase [Energy production and conversion]; Region: COG2414 441771005488 Aldehyde ferredoxin oxidoreductase, N-terminal domain; Region: AFOR_N; pfam02730 441771005489 Aldehyde ferredoxin oxidoreductase, domains 2 & 3; Region: AFOR_C; pfam01314 441771005490 Transcriptional activator of acetoin/glycerol metabolism [Secondary metabolites biosynthesis, transport, and catabolism / Transcription]; Region: AcoR; COG3284 441771005491 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 441771005492 putative active site [active] 441771005493 heme pocket [chemical binding]; other site 441771005494 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 441771005495 Walker A motif; other site 441771005496 ATP binding site [chemical binding]; other site 441771005497 Walker B motif; other site 441771005498 arginine finger; other site 441771005499 Bacterial regulatory protein, Fis family; Region: HTH_8; pfam02954 441771005500 MOSC domain; Region: MOSC; pfam03473 441771005501 MoaC family, prokaryotic and eukaryotic. Members of this family are involved in molybdenum cofactor (Moco) biosynthesis, an essential cofactor of a diverse group of redox enzymes. MoaC, a small hexameric protein, converts, together with MoaA, a guanosine...; Region: MoaC_PE; cd01420 441771005502 trimer interface [polypeptide binding]; other site 441771005503 dimer interface [polypeptide binding]; other site 441771005504 putative active site [active] 441771005505 molybdenum cofactor biosynthesis protein A, bacterial; Region: moaA; TIGR02666 441771005506 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 441771005507 FeS/SAM binding site; other site 441771005508 Molybdenum Cofactor Synthesis C; Region: Mob_synth_C; pfam06463 441771005509 putative molybdopterin biosynthesis protein MoeA/LysR substrate binding-domain-containing protein; Provisional; Region: PRK14498 441771005510 MoeA family. Members of this family are involved in biosynthesis of the molybdenum cofactor (MoCF), an essential cofactor of a diverse group of redox enzymes. MoCF biosynthesis is an evolutionarily conserved pathway present in eubacteria, archaea and...; Region: MoeA; cd00887 441771005511 dimer interface [polypeptide binding]; other site 441771005512 putative functional site; other site 441771005513 putative MPT binding site; other site 441771005514 PBP superfamily domain; Region: PBP_like; pfam12727 441771005515 Molybdopterin biosynthesis enzyme [Coenzyme metabolism]; Region: MoeA; COG0303 441771005516 MoeA family. Members of this family are involved in biosynthesis of the molybdenum cofactor (MoCF), an essential cofactor of a diverse group of redox enzymes. MoCF biosynthesis is an evolutionarily conserved pathway present in eubacteria, archaea and...; Region: MoeA; cd00887 441771005517 dimer interface [polypeptide binding]; other site 441771005518 putative functional site; other site 441771005519 putative MPT binding site; other site 441771005520 MogA_MoaB family. Members of this family are involved in biosynthesis of the molybdenum cofactor (MoCF) an essential cofactor of a diverse group of redox enzymes. MoCF biosynthesis is an evolutionarily conserved pathway present in eubacteria, archaea; Region: MogA_MoaB; cd00886 441771005521 MPT binding site; other site 441771005522 trimer interface [polypeptide binding]; other site 441771005523 phosphate ABC transporter, ATP-binding protein; Region: 3a0107s01c2; TIGR00972 441771005524 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 441771005525 Walker A/P-loop; other site 441771005526 ATP binding site [chemical binding]; other site 441771005527 Q-loop/lid; other site 441771005528 ABC transporter signature motif; other site 441771005529 Walker B; other site 441771005530 D-loop; other site 441771005531 H-loop/switch region; other site 441771005532 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 441771005533 dimer interface [polypeptide binding]; other site 441771005534 conserved gate region; other site 441771005535 putative PBP binding loops; other site 441771005536 ABC-ATPase subunit interface; other site 441771005537 ABC transporter, phosphonate, periplasmic substrate-binding protein; Region: Phosphonate-bd; cl19131 441771005538 Na+-driven multidrug efflux pump [Defense mechanisms]; Region: NorM; COG0534 441771005539 Subfamily of the multidrug and toxic compound extrusion (MATE)-like proteins similar to Bacillus subtilis yoeA; Region: MATE_yoeA_like; cd13138 441771005540 Uncharacterized conserved protein [Function unknown]; Region: COG0398 441771005541 ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136 441771005542 ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255 441771005543 Walker A/P-loop; other site 441771005544 ATP binding site [chemical binding]; other site 441771005545 Q-loop/lid; other site 441771005546 ABC transporter signature motif; other site 441771005547 Walker B; other site 441771005548 D-loop; other site 441771005549 H-loop/switch region; other site 441771005550 MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704 441771005551 ABC-type antimicrobial peptide transport system, permease component [Defense mechanisms]; Region: SalY; COG0577 441771005552 FtsX-like permease family; Region: FtsX; pfam02687 441771005553 ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132 441771005554 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 441771005555 ATP-binding cassette domain of glucan transporter and related proteins, subfamily C; Region: ABCC_Glucan_exporter_like; cd03254 441771005556 Walker A/P-loop; other site 441771005557 ATP binding site [chemical binding]; other site 441771005558 Q-loop/lid; other site 441771005559 ABC transporter signature motif; other site 441771005560 Walker B; other site 441771005561 D-loop; other site 441771005562 H-loop/switch region; other site 441771005563 ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132 441771005564 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 441771005565 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 441771005566 Walker A/P-loop; other site 441771005567 ATP binding site [chemical binding]; other site 441771005568 Q-loop/lid; other site 441771005569 ABC transporter signature motif; other site 441771005570 Walker B; other site 441771005571 D-loop; other site 441771005572 H-loop/switch region; other site 441771005573 Predicted transcriptional regulators [Transcription]; Region: SoxR; COG0789 441771005574 Helix-Turn-Helix DNA binding domain of the BltR transcription regulator; Region: HTH_BltR; cd04782 441771005575 DNA binding residues [nucleotide binding] 441771005576 dimer interface [polypeptide binding]; other site 441771005577 GyrI-like small molecule binding domain; Region: GyrI-like; cl01368 441771005578 Multimeric flavodoxin WrbA [General function prediction only]; Region: WrbA; COG0655 441771005579 Leucine Rich repeats (2 copies); Region: LRR_4; pfam12799 441771005580 Leucine rich repeat; Region: LRR_8; pfam13855 441771005581 Leucine Rich repeats (2 copies); Region: LRR_4; pfam12799 441771005582 Leucine rich repeat; Region: LRR_8; pfam13855 441771005583 Leucine Rich repeats (2 copies); Region: LRR_4; pfam12799 441771005584 Leucine Rich repeats (2 copies); Region: LRR_4; pfam12799 441771005585 M6 family metalloprotease domain; Region: M6dom_TIGR03296 441771005586 chitin-binding domain of Chi A1-like proteins; Region: ChiA1_BD; cd12214 441771005587 Transcriptional regulator containing PAS, AAA-type ATPase, and DNA-binding domains [Transcription / Signal transduction mechanisms]; Region: RocR; COG3829 441771005588 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 441771005589 Walker A motif; other site 441771005590 ATP binding site [chemical binding]; other site 441771005591 Walker B motif; other site 441771005592 arginine finger; other site 441771005593 Glutaredoxin-related protein [Posttranslational modification, protein turnover, chaperones]; Region: COG4545 441771005594 YjgF, YER057c, and UK114 belong to a large family of proteins present in bacteria, archaea, and eukaryotes with no definitive function. The conserved domain is similar in structure to chorismate mutase but there is no sequence similarity and no...; Region: YjgF_YER057c_UK114_family; cd00448 441771005595 homotrimer interaction site [polypeptide binding]; other site 441771005596 putative active site [active] 441771005597 Sodium:dicarboxylate symporter family; Region: SDF; pfam00375 441771005598 putative C-S lyase; Region: C_S_lyase_PatB; TIGR04350 441771005599 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 441771005600 pyridoxal 5'-phosphate binding site [chemical binding]; other site 441771005601 homodimer interface [polypeptide binding]; other site 441771005602 catalytic residue [active] 441771005603 L-cysteine desulfidase [Amino acid transport and metabolism]; Region: COG3681 441771005604 M6 family metalloprotease domain; Region: M6dom_TIGR03296 441771005605 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 441771005606 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 441771005607 dimerization interface [polypeptide binding]; other site 441771005608 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 441771005609 dimer interface [polypeptide binding]; other site 441771005610 phosphorylation site [posttranslational modification] 441771005611 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 441771005612 ATP binding site [chemical binding]; other site 441771005613 Mg2+ binding site [ion binding]; other site 441771005614 G-X-G motif; other site 441771005615 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 441771005616 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 441771005617 active site 441771005618 phosphorylation site [posttranslational modification] 441771005619 intermolecular recognition site; other site 441771005620 dimerization interface [polypeptide binding]; other site 441771005621 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 441771005622 DNA binding site [nucleotide binding] 441771005623 Uncharacterized ArCR, COG2043; Region: DUF169; pfam02596 441771005624 ABC-type cobalt transport system, permease component CbiQ and related transporters [Inorganic ion transport and metabolism]; Region: CbiQ; COG0619 441771005625 ATPase components of various ABC-type transport systems, contain duplicated ATPase [General function prediction only]; Region: COG1123 441771005626 First domain of the ATP-binding cassette component of cobalt transport system; Region: ABC_cobalt_CbiO_domain1; cd03225 441771005627 Walker A/P-loop; other site 441771005628 ATP binding site [chemical binding]; other site 441771005629 Q-loop/lid; other site 441771005630 ABC transporter signature motif; other site 441771005631 Walker B; other site 441771005632 D-loop; other site 441771005633 H-loop/switch region; other site 441771005634 First domain of the ATP-binding cassette component of cobalt transport system; Region: ABC_cobalt_CbiO_domain1; cd03225 441771005635 Walker A/P-loop; other site 441771005636 ATP binding site [chemical binding]; other site 441771005637 Q-loop/lid; other site 441771005638 ABC transporter signature motif; other site 441771005639 Walker B; other site 441771005640 D-loop; other site 441771005641 H-loop/switch region; other site 441771005642 ABC-type cobalt transport system, permease component; Region: ABC_cobalt; pfam09819 441771005643 Predicted amino acid racemase [Amino acid transport and metabolism]; Region: COG3457 441771005644 Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzyme Alanine Racemase-like 1; Region: PLPDE_III_AR_like_1; cd06815 441771005645 dimer interface [polypeptide binding]; other site 441771005646 active site 441771005647 pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site 441771005648 substrate binding site [chemical binding]; other site 441771005649 catalytic residue [active] 441771005650 Spore germination protein; Region: Spore_permease; cl17796 441771005651 Bacillus/Clostridium GerA spore germination protein; Region: GerA; pfam03323 441771005652 Spore germination protein; Region: Spore_permease; cl17796 441771005653 Spore germination B3/ GerAC like, C-terminal; Region: Spore_GerAC; cl19906 441771005654 Spore germination protein; Region: Spore_permease; cl17796 441771005655 Putative redox-active protein (C_GCAxxG_C_C); Region: C_GCAxxG_C_C; pfam09719 441771005656 alkylhydroperoxidase/carboxymuconolactone decarboxylase family protein; Region: perox_w_seleSAM; TIGR04169 441771005657 radical SAM/Cys-rich domain protein; Region: rSAM_SeCys; TIGR04167 441771005658 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 441771005659 FeS/SAM binding site; other site 441771005660 Protein of unknown function (DUF3641); Region: DUF3641; pfam12345 441771005661 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 441771005662 binding surface 441771005663 TPR repeat; Region: TPR_11; pfam13414 441771005664 TPR motif; other site 441771005665 TPR repeat; Region: TPR_11; pfam13414 441771005666 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 441771005667 binding surface 441771005668 TPR motif; other site 441771005669 TPR repeat; Region: TPR_11; pfam13414 441771005670 NhaP-type Na+/H+ and K+/H+ antiporters [Inorganic ion transport and metabolism]; Region: NhaP; COG0025 441771005671 potassium/proton antiporter; Reviewed; Region: PRK05326 441771005672 TrkA-C domain; Region: TrkA_C; pfam02080 441771005673 heat shock protein 90; Provisional; Region: PRK05218 441771005674 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 441771005675 ATP binding site [chemical binding]; other site 441771005676 Mg2+ binding site [ion binding]; other site 441771005677 G-X-G motif; other site 441771005678 Hsp90 protein; Region: HSP90; pfam00183 441771005679 DNA-binding domain of DNA mismatch repair MUTS family; Region: MUTSd; smart00533 441771005680 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 441771005681 Walker A/P-loop; other site 441771005682 ATP binding site [chemical binding]; other site 441771005683 Q-loop/lid; other site 441771005684 ABC transporter signature motif; other site 441771005685 Walker B; other site 441771005686 D-loop; other site 441771005687 H-loop/switch region; other site 441771005688 PTS system trehalose(maltose)-specific transporter subunits IIBC; Provisional; Region: PRK11007 441771005689 PTS_IIB, PTS system, glucose/sucrose specific IIB subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIB_glc; cd00212 441771005690 active site turn [active] 441771005691 phosphorylation site [posttranslational modification] 441771005692 Phosphotransferase system IIC components, glucose/maltose/N-acetylglucosamine-specific [Carbohydrate transport and metabolism]; Region: PtsG; COG1263 441771005693 alpha,alpha-phosphotrehalase; Region: trehalose_treC; TIGR02403 441771005694 Alpha amylase catalytic domain found in Sucrose isomerases, oligo-1,6-glucosidase (also called isomaltase; sucrase-isomaltase; alpha-limit dextrinase), dextran glucosidase (also called glucan 1,6-alpha-glucosidase), and related proteins; Region: AmyAc_SI_OligoGlu_DGase; cd11333 441771005695 Ca binding site [ion binding]; other site 441771005696 active site 441771005697 catalytic site [active] 441771005698 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 441771005699 DNA-binding site [nucleotide binding]; DNA binding site 441771005700 trehalose operon repressor, B. subtilis-type; Region: trehalos_R_Bsub; TIGR02404 441771005701 UTRA domain; Region: UTRA; pfam07702 441771005702 PTS_IIA, PTS system, fructose/mannitol specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_fru; cd00211 441771005703 active site 441771005704 phosphorylation site [posttranslational modification] 441771005705 putative PTS system transporter subunits IIBC; Provisional; Region: PRK11404 441771005706 PTS_IIB_fructose: subunit IIB of enzyme II (EII) of the fructose-specific phosphoenolpyruvate:carbohydrate phosphotransferase system (PTS). In this system, EII (also referred to as FruAB) is a fructose-specific permease made up of two proteins (FruA and...; Region: PTS_IIB_fructose; cd05569 441771005707 active site 441771005708 P-loop; other site 441771005709 phosphorylation site [posttranslational modification] 441771005710 Phosphotransferase system, fructose-specific IIC component [Carbohydrate transport and metabolism]; Region: FruA; COG1299 441771005711 1-phosphofructokinase (FruK), minor 6-phosphofructokinase (pfkB) and related sugar kinases. FruK plays an important role in the predominant pathway for fructose utilisation.This group also contains tagatose-6-phophate kinase, an enzyme of the tagatose...; Region: FruK_PfkB_like; cd01164 441771005712 putative substrate binding site [chemical binding]; other site 441771005713 putative ATP binding site [chemical binding]; other site 441771005714 Tagatose-1,6-bisphosphate (TBP) aldolase and related Type B Class II aldolases. TBP aldolase is a tetrameric class II aldolase that catalyzes the reversible condensation of dihydroxyacetone phosphate with glyceraldehyde 3-phsophate to produce tagatose 1; Region: TBP_aldolase_IIB; cd00947 441771005715 intersubunit interface [polypeptide binding]; other site 441771005716 active site 441771005717 zinc binding site [ion binding]; other site 441771005718 Na+ binding site [ion binding]; other site 441771005719 Transcriptional regulators [Transcription]; Region: RpiR; COG1737 441771005720 Helix-turn-helix domain, rpiR family; Region: HTH_6; pfam01418 441771005721 RpiR-like protein. RpiR contains a SIS (Sugar ISomerase) domain, which is found in many phosphosugar isomerases and phosphosugar binding proteins. In E. coli, rpiR negatively regulates the expression of rpiB gene. Both rpiB and rpiA are ribose phosphate...; Region: SIS_RpiR; cd05013 441771005722 putative active site [active] 441771005723 Protein of unknown function (DUF2992); Region: DUF2992; pfam11208 441771005724 YjgF, YER057c, and UK114 belong to a large family of proteins present in bacteria, archaea, and eukaryotes with no definitive function. The conserved domain is similar in structure to chorismate mutase but there is no sequence similarity and no...; Region: YjgF_YER057c_UK114_family; cd00448 441771005725 homotrimer interaction site [polypeptide binding]; other site 441771005726 putative active site [active] 441771005727 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 441771005728 Radical SAM superfamily; Region: Radical_SAM; pfam04055 441771005729 FeS/SAM binding site; other site 441771005730 Glycerol dehydrogenases (GlyDH) catalyzes oxidation of glycerol to dihydroxyacetone in glycerol dissmilation; Region: GlyDH; cd08170 441771005731 dimer interface [polypeptide binding]; other site 441771005732 active site 441771005733 metal binding site [ion binding]; metal-binding site 441771005734 Sensory domain of two-component sensor kinase; Region: Cache_3; pfam14827 441771005735 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 441771005736 dimerization interface [polypeptide binding]; other site 441771005737 Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer); Region: MA; smart00283 441771005738 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cl19050 441771005739 dimer interface [polypeptide binding]; other site 441771005740 putative CheW interface [polypeptide binding]; other site 441771005741 Predicted amino acid racemase [Amino acid transport and metabolism]; Region: COG3457 441771005742 Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzyme Alanine Racemase-like 1; Region: PLPDE_III_AR_like_1; cd06815 441771005743 dimer interface [polypeptide binding]; other site 441771005744 active site 441771005745 pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site 441771005746 substrate binding site [chemical binding]; other site 441771005747 catalytic residue [active] 441771005748 ATP cone domain; Region: ATP-cone; pfam03477 441771005749 putative oxidoreductase; Provisional; Region: PRK11579 441771005750 Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408 441771005751 Oxidoreductase family, C-terminal alpha/beta domain; Region: GFO_IDH_MocA_C; pfam02894 441771005752 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 441771005753 active site 441771005754 Xanthine/uracil/vitamin C permease [Nucleotide transport and metabolism]; Region: COG2252 441771005755 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 441771005756 metal binding site [ion binding]; metal-binding site 441771005757 active site 441771005758 I-site; other site 441771005759 L-cysteine desulfidase [Amino acid transport and metabolism]; Region: COG3681 441771005760 Transcriptional regulator containing PAS, AAA-type ATPase, and DNA-binding domains [Transcription / Signal transduction mechanisms]; Region: RocR; COG3829 441771005761 PAS domain; Region: PAS; smart00091 441771005762 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 441771005763 Walker A motif; other site 441771005764 ATP binding site [chemical binding]; other site 441771005765 Walker B motif; other site 441771005766 arginine finger; other site 441771005767 Bacterial regulatory protein, Fis family; Region: HTH_8; cl17420 441771005768 DEAD-box helicases. A diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker B motif; Region: DEADc; cd00268 441771005769 DEAD-like helicases superfamily; Region: DEXDc; smart00487 441771005770 ATP binding site [chemical binding]; other site 441771005771 Mg++ binding site [ion binding]; other site 441771005772 motif III; other site 441771005773 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 441771005774 nucleotide binding region [chemical binding]; other site 441771005775 ATP-binding site [chemical binding]; other site 441771005776 Uncharacterized protein with SCP/PR1 domains [Function unknown]; Region: COG2340 441771005777 SCP_bacterial: SCP-like extracellular protein domain, as found in bacteria and archaea. The wider family of SCP containing proteins includes plant pathogenesis-related protein 1 (PR-1), CRISPs, mammalian cysteine-rich secretory proteins, and allergen 5...; Region: SCP_bacterial; cd05379 441771005778 Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain (MocR family) and their eukaryotic orthologs [Transcription / Amino acid transport and metabolism]; Region: ARO8; COG1167 441771005779 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 441771005780 DNA-binding site [nucleotide binding]; DNA binding site 441771005781 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 441771005782 pyridoxal 5'-phosphate binding site [chemical binding]; other site 441771005783 homodimer interface [polypeptide binding]; other site 441771005784 catalytic residue [active] 441771005785 Permeases of the drug/metabolite transporter (DMT) superfamily [Carbohydrate transport and metabolism / Amino acid transport and metabolism / General function prediction only]; Region: RhaT; COG0697 441771005786 EamA-like transporter family; Region: EamA; pfam00892 441771005787 EamA-like transporter family; Region: EamA; pfam00892 441771005788 aspartate aminotransferase; Provisional; Region: PRK06348 441771005789 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 441771005790 pyridoxal 5'-phosphate binding site [chemical binding]; other site 441771005791 homodimer interface [polypeptide binding]; other site 441771005792 catalytic residue [active] 441771005793 ABC-type polar amino acid transport system, ATPase component [Amino acid transport and metabolism]; Region: GlnQ; COG1126 441771005794 ATP-binding cassette domain of the histidine and glutamine transporters; Region: ABC_HisP_GlnQ; cd03262 441771005795 Walker A/P-loop; other site 441771005796 ATP binding site [chemical binding]; other site 441771005797 Q-loop/lid; other site 441771005798 ABC transporter signature motif; other site 441771005799 Walker B; other site 441771005800 D-loop; other site 441771005801 H-loop/switch region; other site 441771005802 ABC-type amino acid transport system, permease component [Amino acid transport and metabolism]; Region: HisM; COG0765 441771005803 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 441771005804 dimer interface [polypeptide binding]; other site 441771005805 conserved gate region; other site 441771005806 putative PBP binding loops; other site 441771005807 ABC-ATPase subunit interface; other site 441771005808 Bacterial extracellular solute-binding proteins, family 3; Region: SBP_bac_3; pfam00497 441771005809 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 441771005810 substrate binding pocket [chemical binding]; other site 441771005811 membrane-bound complex binding site; other site 441771005812 hinge residues; other site 441771005813 Domain of unknown function (DUF2088); Region: DUF2088; cl15406 441771005814 Serine-pyruvate aminotransferase/archaeal aspartate aminotransferase [Amino acid transport and metabolism]; Region: COG0075 441771005815 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 441771005816 catalytic residue [active] 441771005817 Chloramphenicol acetyltransferase; Region: CAT; cl02008 441771005818 Nucleic-acid-binding protein containing Zn-ribbon domain (DUF2082); Region: DUF2082; pfam09855 441771005819 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4443 441771005820 AAA domain; Region: AAA_12; pfam13087 441771005821 Alpha/beta hydrolase family; Region: Abhydrolase_5; pfam12695 441771005822 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 441771005823 sequence-specific DNA binding site [nucleotide binding]; other site 441771005824 salt bridge; other site 441771005825 Dipeptide/tripeptide permease [Amino acid transport and metabolism]; Region: PTR2; COG3104 441771005826 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 441771005827 putative substrate translocation pore; other site 441771005828 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 441771005829 Major Facilitator Superfamily; Region: MFS_1; pfam07690 441771005830 putative substrate translocation pore; other site 441771005831 Xaa-Pro aminopeptidase [Amino acid transport and metabolism]; Region: PepP; COG0006 441771005832 Creatinase/Prolidase N-terminal domain; Region: Creatinase_N; pfam01321 441771005833 Similar to Prolidase and Aminopeptidase P. The members of this subfamily presumably catalyse hydrolysis of Xaa-Pro dipeptides and/or release of any N-terminal amino acid, including proline, that is linked with proline; Region: APP-like; cd01092 441771005834 active site 441771005835 proline-specific peptidase, Bacillus coagulans-type subfamily; Region: pro_imino_pep_2; TIGR01250 441771005836 Putative lysophospholipase; Region: Hydrolase_4; cl19140 441771005837 uncharacterized bacterial and archaeal solute carrier 6 subfamily; solute-binding domain; Region: SLC6sbd_u1; cd10334 441771005838 Na2 binding site [ion binding]; other site 441771005839 putative substrate binding site 1 [chemical binding]; other site 441771005840 Na binding site 1 [ion binding]; other site 441771005841 putative substrate binding site 2 [chemical binding]; other site 441771005842 Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain (MocR family) and their eukaryotic orthologs [Transcription / Amino acid transport and metabolism]; Region: ARO8; COG1167 441771005843 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 441771005844 DNA-binding site [nucleotide binding]; DNA binding site 441771005845 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 441771005846 pyridoxal 5'-phosphate binding site [chemical binding]; other site 441771005847 homodimer interface [polypeptide binding]; other site 441771005848 catalytic residue [active] 441771005849 Predicted epimerase, PhzC/PhzF homolog [General function prediction only]; Region: COG0384 441771005850 Diaminopimelate epimerase; Region: DAP_epimerase; cl19724 441771005851 This group of proteins belong to a large family of YjgF/YER057c/UK114-like proteins present in bacteria, archaea, and eukaryotes with no definitive function. The conserved domain is similar in structure to chorismate mutase but there is no sequence...; Region: YjgF_YER057c_UK114_like_1; cd02199 441771005852 homotrimer interaction site [polypeptide binding]; other site 441771005853 putative active site [active] 441771005854 Lipase. Lipases are esterases that can hydrolyze long-chain acyl-triglycerides into di- and monoglycerides, glycerol, and free fatty acids at a water/lipid interface. A typical feature of lipases is "interfacial activation", the process of...; Region: Lipase; cl14883 441771005855 nucleophilic elbow; other site 441771005856 catalytic triad; other site 441771005857 NAD(P)H:flavin oxidoreductase-like family 1. A subfamily of the nitroreductase family containing uncharacterized proteins that are similar to nitroreductase. Nitroreductase catalyzes the reduction of nitroaromatic compounds such as nitrotoluenes; Region: NADPH_oxidoreductase_1; cd02150 441771005858 putative FMN binding site [chemical binding]; other site 441771005859 Von Willebrand factor type A (vWA) domain was originally found in the blood coagulation protein von Willebrand factor (vWF). Typically, the vWA domain is made up of approximately 200 amino acid residues folded into a classic a/b para-rossmann type of...; Region: vWFA; cd00198 441771005860 metal ion-dependent adhesion site (MIDAS); other site 441771005861 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cl18944 441771005862 myosin-cross-reactive antigen; Provisional; Region: PRK13977 441771005863 Streptococcal 67 kDa myosin-cross-reactive antigen like family; Region: Strep_67kDa_ant; pfam06100 441771005864 probable dihydroxyacetone kinase regulator; Region: DHAK_reg; TIGR02366 441771005865 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 441771005866 Phage protein Gp37/Gp68; Region: Gp37_Gp68; cl15384 441771005867 Glycosyl transferase family 2; Region: Glycos_transf_2; pfam00535 441771005868 active site 441771005869 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cd00761 441771005870 active site 441771005871 Glycosyltransferases, probably involved in cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: COG1215 441771005872 Putative Acyltransferase (AT), Left-handed parallel beta-Helix (LbH) domain; This group is composed of mostly uncharacterized proteins containing an N-terminal helical subdomain followed by a LbH domain. The alignment contains 6 turns, each containing...; Region: LbH_AT_putative; cd03360 441771005873 sugar O-acyltransferase, sialic acid O-acetyltransferase NeuD family; Region: NeuD_NnaD; TIGR03570 441771005874 putative trimer interface [polypeptide binding]; other site 441771005875 putative CoA binding site [chemical binding]; other site 441771005876 3-amino-5-hydroxybenzoic acid synthase family (AHBA_syn). AHBA_syn family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The members of this CD are involved in various biosynthetic pathways for secondary...; Region: AHBA_syn; cd00616 441771005877 inhibitor-cofactor binding pocket; inhibition site 441771005878 pyridoxal 5'-phosphate binding site [chemical binding]; other site 441771005879 catalytic residue [active] 441771005880 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394 441771005881 Predicted glycosyltransferases [General function prediction only]; Region: COG1216 441771005882 active site 441771005883 G1P_TT_long represents the long form of glucose-1-phosphate thymidylyltransferase; Region: G1P_TT_long; cd04189 441771005884 glucose-1-phosphate thymidylylransferase, long form; Region: rmlA_long; TIGR01208 441771005885 substrate binding site; other site 441771005886 metal-binding site 441771005887 Oligomer interface; other site 441771005888 Left-handed parallel beta-Helix (LbetaH or LbH) domain: The alignment contains 5 turns, each containing three imperfect tandem repeats of a hexapeptide repeat motif (X-[STAV]-X-[LIV]-[GAED]-X). Proteins containing hexapeptide repeats are often enzymes...; Region: LbetaH; cl00160 441771005889 dTDP-D-glucose 4,6-dehydratase, extended (e) SDRs; Region: dTDP_GD_SDR_e; cd05246 441771005890 dTDP-D-glucose 4,6-dehydratase [Cell envelope biogenesis, outer membrane]; Region: RfbB; COG1088 441771005891 NAD binding site [chemical binding]; other site 441771005892 substrate binding site [chemical binding]; other site 441771005893 homodimer interface [polypeptide binding]; other site 441771005894 active site 441771005895 Domain of unknown function (DUF4342); Region: DUF4342; pfam14242 441771005896 Domain of unknown function (DUF4342); Region: DUF4342; pfam14242 441771005897 Putative lysophospholipase; Region: Hydrolase_4; cl19140 441771005898 Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596 441771005899 VanZ like family; Region: VanZ; pfam04892 441771005900 Protein of unknown function (DUF4065); Region: DUF4065; pfam13274 441771005901 ABC-2 family transporter protein; Region: ABC2_membrane_5; pfam13346 441771005902 ABC-type multidrug transport system, ATPase component [Defense mechanisms]; Region: CcmA; COG1131 441771005903 ATP-binding cassette domain of the drug resistance transporter and related proteins, subfamily A; Region: ABC_DR_subfamily_A; cd03230 441771005904 Walker A/P-loop; other site 441771005905 ATP binding site [chemical binding]; other site 441771005906 Q-loop/lid; other site 441771005907 ABC transporter signature motif; other site 441771005908 Walker B; other site 441771005909 D-loop; other site 441771005910 H-loop/switch region; other site 441771005911 Predicted transcriptional regulators [Transcription]; Region: COG1725 441771005912 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 441771005913 DNA-binding site [nucleotide binding]; DNA binding site 441771005914 This family includes the Gtfs, a group of homologous glycosyltransferases involved in the final stages of the biosynthesis of antibiotics vancomycin and related chloroeremomycin. Gtfs transfer sugar moieties from an activated NDP-sugar donor to the...; Region: GT1_Gtf_like; cd03784 441771005915 glycosyltransferase, MGT family; Region: MGT; TIGR01426 441771005916 active site 441771005917 TDP-binding site; other site 441771005918 acceptor substrate-binding pocket; other site 441771005919 homodimer interface [polypeptide binding]; other site 441771005920 looped-hinge helix DNA binding domain, AbrB family; Region: lp_hng_hel_AbrB; TIGR01439 441771005921 endonuclease III; includes endonuclease III (DNA-(apurinic or apyrimidinic site) lyase), alkylbase DNA glycosidases (Alka-family) and other DNA glycosidases; Region: ENDO3c; cl19066 441771005922 helix-hairpin-helix signature motif; other site 441771005923 substrate binding pocket [chemical binding]; other site 441771005924 endonuclease III; includes endonuclease III (DNA-(apurinic or apyrimidinic site) lyase), alkylbase DNA glycosidases (Alka-family) and other DNA glycosidases; Region: ENDO3c; cl19066 441771005925 active site 441771005926 iron-sulpphur binding domain in DNA-(apurinic or apyrimidinic site) lyase (subfamily of ENDO3); Region: FES; smart00525 441771005927 Cytosine deaminase and related metal-dependent hydrolases [Nucleotide transport and metabolism / General function prediction only]; Region: SsnA; COG0402 441771005928 Bacterial cytosine deaminase and related metal-dependent hydrolases. Cytosine deaminases (CDs) catalyze the deamination of cytosine, producing uracil and ammonia. They play an important role in pyrimidine salvage. CDs are present in prokaryotes and fungi; Region: Bact_CD; cd01293 441771005929 active site 441771005930 nucleobase-cation-symport-1 (NCS1) transporter CobB-like; solute-binding domain; Region: SLC-NCS1sbd_CobB-like; cd11484 441771005931 Na binding site [ion binding]; other site 441771005932 putative substrate binding site [chemical binding]; other site 441771005933 ABC-type cobalt transport system, ATPase component [Inorganic ion transport and metabolism]; Region: CbiO; COG1122 441771005934 First domain of the ATP-binding cassette component of cobalt transport system; Region: ABC_cobalt_CbiO_domain1; cd03225 441771005935 Walker A/P-loop; other site 441771005936 ATP binding site [chemical binding]; other site 441771005937 Q-loop/lid; other site 441771005938 ABC transporter signature motif; other site 441771005939 Walker B; other site 441771005940 D-loop; other site 441771005941 H-loop/switch region; other site 441771005942 ABC-type cobalt transport system, ATPase component [Inorganic ion transport and metabolism]; Region: CbiO; COG1122 441771005943 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 441771005944 Walker A/P-loop; other site 441771005945 ATP binding site [chemical binding]; other site 441771005946 Q-loop/lid; other site 441771005947 ABC transporter signature motif; other site 441771005948 Walker B; other site 441771005949 D-loop; other site 441771005950 H-loop/switch region; other site 441771005951 ABC-type cobalt transport system, permease component CbiQ and related transporters [Inorganic ion transport and metabolism]; Region: CbiQ; COG0619 441771005952 Hypothetical bacterial integral membrane protein (Trep_Strep); Region: Trep_Strep; pfam09605 441771005953 Helix-turn-helix domain; Region: HTH_18; pfam12833 441771005954 Acetyltransferase (GNAT) domain; Region: Acetyltransf_8; pfam13523 441771005955 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 441771005956 Coenzyme A binding pocket [chemical binding]; other site 441771005957 conserved hypothetical protein (putative transposase or invertase); Region: T_den_put_tspse; TIGR01784 441771005958 The MutT pyrophosphohydrolase is a prototypical Nudix hydrolase that catalyzes the hydrolysis of nucleoside and deoxynucleoside triphosphates (NTPs and dNTPs) by substitution at a beta-phosphorus to yield a nucleotide monophosphate (NMP) and inorganic...; Region: MutT_pyrophosphohydrolase; cd03425 441771005959 active site 441771005960 8-oxo-dGMP binding site [chemical binding]; other site 441771005961 nudix motif; other site 441771005962 metal binding site [ion binding]; metal-binding site 441771005963 N-terminal putative catalytic domain of uncharacterized prokaryotic and archeal HKD family nucleases fused to a DEAD/DEAH box helicase domain; Region: PLDc_N_DEXD_b2; cd09204 441771005964 PLD-like domain; Region: PLDc_2; pfam13091 441771005965 putative homodimer interface [polypeptide binding]; other site 441771005966 putative active site [active] 441771005967 catalytic site [active] 441771005968 DEAD-like helicases superfamily; Region: DEXDc; smart00487 441771005969 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 441771005970 ATP binding site [chemical binding]; other site 441771005971 putative Mg++ binding site [ion binding]; other site 441771005972 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 441771005973 nucleotide binding region [chemical binding]; other site 441771005974 ATP-binding site [chemical binding]; other site 441771005975 Domain of unknown function (DUF3427); Region: DUF3427; pfam11907 441771005976 Superfamily I DNA and RNA helicases [DNA replication, recombination, and repair]; Region: UvrD; COG0210 441771005977 Part of AAA domain; Region: AAA_19; pfam13245 441771005978 UvrD-like helicase C-terminal domain; Region: UvrD_C_2; cl19402 441771005979 AAA ATPase domain; Region: AAA_15; pfam13175 441771005980 AAA domain; Region: AAA_23; pfam13476 441771005981 Walker A/P-loop; other site 441771005982 ATP binding site [chemical binding]; other site 441771005983 AAA domain; Region: AAA_21; pfam13304 441771005984 TOPRIM_OLD: topoisomerase-primase (TOPRIM) nucleotidyl transferase/hydrolase domain of the type found in bacterial and archaeal nucleases of the OLD (overcome lysogenization defect) family. The bacteriophage P2 OLD protein, which has DNase as well as...; Region: TOPRIM_OLD; cd01026 441771005985 putative active site [active] 441771005986 putative metal-binding site [ion binding]; other site 441771005987 Predicted nucleotide-binding protein containing TIR-like domain; Region: TIR-like; cl17861 441771005988 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 441771005989 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 441771005990 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 441771005991 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3708 441771005992 Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596 441771005993 Putative lysophospholipase; Region: Hydrolase_4; cl19140 441771005994 Translation_Factor_II_like: Elongation factor Tu (EF-Tu) domain II-like proteins. Elongation factor Tu consists of three structural domains, this family represents the second domain. Domain II adopts a beta barrel structure and is involved in binding to...; Region: Translation_Factor_II_like; cl02787 441771005995 Nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: WcaG; COG0451 441771005996 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 441771005997 NAD(P) binding site [chemical binding]; other site 441771005998 active site 441771005999 Glycosyltransferases involved in cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WcaA; COG0463 441771006000 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cd00761 441771006001 active site 441771006002 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cd00761 441771006003 active site 441771006004 Glycosyltransferases involved in cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WcaA; COG0463 441771006005 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cd00761 441771006006 active site 441771006007 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 441771006008 This family is most closely related to the GT1 family of glycosyltransferases and named after YqgM in Bacillus licheniformis about which little is known. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to...; Region: GT1_YqgM_like; cd03801 441771006009 Tet(M)-like family includes Tet(M), Tet(O), Tet(W), and OtrA, containing tetracycline resistant proteins; Region: TetM_like; cd04168 441771006010 Translation elongation factors (GTPases) [Translation, ribosomal structure and biogenesis]; Region: FusA; COG0480 441771006011 G1 box; other site 441771006012 putative GEF interaction site [polypeptide binding]; other site 441771006013 GTP/Mg2+ binding site [chemical binding]; other site 441771006014 Switch I region; other site 441771006015 G2 box; other site 441771006016 G3 box; other site 441771006017 Switch II region; other site 441771006018 G4 box; other site 441771006019 G5 box; other site 441771006020 Tet_II: This subfamily represents domain II of ribosomal protection proteins Tet(M) and Tet(O). This domain has homology to domain II of the elongation factors EF-G and EF-2. Tet(M) and Tet(O) catalyze the release of tetracycline (Tc) from the ribosome...; Region: Tet_II; cd03690 441771006021 Elongation Factor G, domain II; Region: EFG_II; pfam14492 441771006022 Elongation Factor G-like domain IV. This family includes the translational elongation factor termed EF-2 (for Archaea and Eukarya) and EF-G (for Bacteria), ribosomal protection proteins that mediate tetracycline resistance and, an evolutionarily...; Region: EFG_like_IV; cl02789 441771006023 Tet_C: C-terminus of ribosomal protection proteins Tet(M) and Tet(O). This domain has homology to the C terminal domains of the elongation factors EF-G and EF-2. Tet(M) and Tet(O) catalyze the release of tetracycline (Tc) from the ribosome in a...; Region: Tet_C; cd03711 441771006024 Domain of unknown function (DUF3472); Region: DUF3472; pfam11958 441771006025 Peptidase M60-like family; Region: M60-like; cl19940 441771006026 Chitin-binding domain of chitinase C; Region: ChiC_BD; cd12215 441771006027 aromatic chitin/cellulose binding site residues [chemical binding]; other site 441771006028 Carbon dioxide concentrating mechanism/carboxysome shell protein [Secondary metabolites biosynthesis, transport, and catabolism / Energy production and conversion]; Region: CcmK; COG4577 441771006029 1,2-propanediol utilization protein A (PduA), Bacterial Micro-Compartment (BMC) domain; Region: BMC_PduA; cd07059 441771006030 Hexamer interface [polypeptide binding]; other site 441771006031 Putative hexagonal pore residue; other site 441771006032 propanediol utilization phosphotransacylase; Provisional; Region: PRK15070 441771006033 Propanediol utilisation protein PduL; Region: PduL; pfam06130 441771006034 Propanediol utilisation protein PduL; Region: PduL; pfam06130 441771006035 Coenzyme A acylating aldehyde dehydrogenase (ACDH), ALDH family 20-like; Region: ALDH_F20_ACDH; cd07122 441771006036 putative catalytic cysteine [active] 441771006037 Carbon dioxide concentrating mechanism/carboxysome shell protein [Secondary metabolites biosynthesis, transport, and catabolism / Energy production and conversion]; Region: CcmK; COG4577 441771006038 Carbon dioxide concentrating mechanism K (CcmK)-like proteins, Bacterial Micro-Compartment (BMC) domain; Region: BMC_CcmK_like; cd07045 441771006039 Hexamer interface [polypeptide binding]; other site 441771006040 Hexagonal pore residue; other site 441771006041 Rotavirus VP2 protein; Region: Rota_VP2; pfam05087 441771006042 ethanolamine utilization protein EutQ; Provisional; Region: PRK15457 441771006043 Ethanolamine utilisation protein and carboxysome structural protein domain family; Region: EutN_CcmL; cd01614 441771006044 Hexamer/Pentamer interface [polypeptide binding]; other site 441771006045 central pore; other site 441771006046 Bacterial Micro-Compartment (BMC)-like domain 2; Region: BMC_like_2; cd07055 441771006047 putative hexamer interface [polypeptide binding]; other site 441771006048 putative hexagonal pore; other site 441771006049 ethanolamine utilization protein EutJ; Provisional; Region: PRK15080 441771006050 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cd00012 441771006051 nucleotide binding site [chemical binding]; other site 441771006052 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cl17037 441771006053 nucleotide binding site [chemical binding]; other site 441771006054 Cobalamin adenosyltransferase; Region: Cob_adeno_trans; cl00920 441771006055 Rat sarcoma (Ras)-like superfamily of small guanosine triphosphatases (GTPases); Region: Ras_like_GTPase; cd00882 441771006056 G1 box; other site 441771006057 GTP/Mg2+ binding site [chemical binding]; other site 441771006058 G2 box; other site 441771006059 Switch I region; other site 441771006060 G3 box; other site 441771006061 Switch II region; other site 441771006062 G4 box; other site 441771006063 G5 box; other site 441771006064 1,2-propanediol utilization protein U (PduU)/ethanolamine utilization protein S (EutS), Bacterial Micro-Compartment (BMC) domain; Region: BMC_PduU-EutS; cd07046 441771006065 putative hexamer interface [polypeptide binding]; other site 441771006066 putative hexagonal pore; other site 441771006067 glycyl-radical enzyme activating protein family; Region: PFLE_PFLC; TIGR02494 441771006068 RPB11 and RPB3 subunits of RNA polymerase; Region: RNAP_RPB11_RPB3; cl11409 441771006069 DRE-TIM metallolyase superfamily; Region: DRE_TIM_metallolyase; cl18962 441771006070 glycyl radical enzyme, PFL2/glycerol dehydratase family; Region: PFL2-3; TIGR01774 441771006071 Pyruvate formate lyase 2 and related enzymes; Region: PFL2_DhaB_BssA; cd01677 441771006072 dimer interface [polypeptide binding]; other site 441771006073 active site 441771006074 glycine loop; other site 441771006075 Coenzyme A acylating aldehyde dehydrogenase (ACDH), ALDH family 20-like; Region: ALDH_F20_ACDH; cd07122 441771006076 putative catalytic cysteine [active] 441771006077 Carbon dioxide concentrating mechanism K (CcmK)-like proteins, Bacterial Micro-Compartment (BMC) domain; Region: BMC_CcmK_like; cd07045 441771006078 Hexamer interface [polypeptide binding]; other site 441771006079 Hexagonal pore residue; other site 441771006080 Carbon dioxide concentrating mechanism K (CcmK)-like proteins, Bacterial Micro-Compartment (BMC) domain; Region: BMC_CcmK_like; cd07045 441771006081 Hexamer interface [polypeptide binding]; other site 441771006082 Hexagonal pore residue; other site 441771006083 Multidrug resistance efflux transporter; Region: EmrE; pfam13536 441771006084 Predicted transcriptional regulators [Transcription]; Region: SoxR; COG0789 441771006085 Helix-Turn-Helix DNA binding domain of the BmrR transcription regulator; Region: HTH_BmrR; cd01107 441771006086 DNA binding residues [nucleotide binding] 441771006087 drug binding residues [chemical binding]; other site 441771006088 dimer interface [polypeptide binding]; other site 441771006089 GyrI-like small molecule binding domain; Region: GyrI-like; cl01368 441771006090 1,3-propanediol dehydrogenase (PPD) catalyzes the reduction of 3-hydroxypropionaldehyde (3-HPA) to 1,3-propanediol in glycerol metabolism; Region: PDD; cd08180 441771006091 putative active site [active] 441771006092 metal binding site [ion binding]; metal-binding site 441771006093 Na+-driven multidrug efflux pump [Defense mechanisms]; Region: NorM; COG0534 441771006094 Subfamily of the multidrug and toxic compound extrusion (MATE)-like proteins similar to Streptococcus aureus MepA; Region: MATE_MepA_like; cd13143 441771006095 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cl17220 441771006096 Transcriptional regulators [Transcription]; Region: MarR; COG1846 441771006097 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 441771006098 Coenzyme A binding pocket [chemical binding]; other site 441771006099 Domain of unknown function (DUF1963); Region: DUF1963; pfam09234 441771006100 Domain of unknown function (DUF4180); Region: DUF4180; pfam13788 441771006101 Helix-turn-helix domain; Region: HTH_17; cl17695 441771006102 Sortase D (SrtD) is a membrane transpeptidase found in gram-positive bacteria that anchors surface proteins to peptidoglycans of the bacterial cell wall envelope. This involves a transpeptidation reaction in which the surface protein substrate is cleaved...; Region: Sortase_D_4; cd05828 441771006103 active site 441771006104 catalytic site [active] 441771006105 Carboxypeptidase regulatory-like domain; Region: CarboxypepD_reg; pfam13620 441771006106 Polymerase and Histidinol Phosphatase domain; Region: PHP; cl17102 441771006107 active site 441771006108 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 441771006109 His Kinase A (phospho-acceptor) domain; Region: HisKA; pfam00512 441771006110 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 441771006111 ATP binding site [chemical binding]; other site 441771006112 Mg2+ binding site [ion binding]; other site 441771006113 G-X-G motif; other site 441771006114 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 441771006115 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 441771006116 active site 441771006117 phosphorylation site [posttranslational modification] 441771006118 intermolecular recognition site; other site 441771006119 dimerization interface [polypeptide binding]; other site 441771006120 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 441771006121 DNA binding site [nucleotide binding] 441771006122 ABC-2 family transporter protein; Region: ABC2_membrane_4; pfam12730 441771006123 Peptidase Gluzincin family (thermolysin-like proteinases, TLPs) includes peptidases M1, M2, M3, M4, M13, M32 and M36 (fungalysins); Region: GluZincin; cl14813 441771006124 Zn binding site [ion binding]; other site 441771006125 ABC-type multidrug transport system, ATPase component [Defense mechanisms]; Region: CcmA; COG1131 441771006126 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 441771006127 Walker A/P-loop; other site 441771006128 ATP binding site [chemical binding]; other site 441771006129 Q-loop/lid; other site 441771006130 ABC transporter signature motif; other site 441771006131 Walker B; other site 441771006132 D-loop; other site 441771006133 H-loop/switch region; other site 441771006134 ABC-type antimicrobial peptide transport system, permease component [Defense mechanisms]; Region: SalY; COG0577 441771006135 FtsX-like permease family; Region: FtsX; pfam02687 441771006136 FtsX-like permease family; Region: FtsX; pfam02687 441771006137 putative oxidoreductase; Provisional; Region: PRK11445 441771006138 geranylgeranyl reductase family; Region: GG-red-SF; TIGR02032 441771006139 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 441771006140 salt bridge; other site 441771006141 non-specific DNA binding site [nucleotide binding]; other site 441771006142 sequence-specific DNA binding site [nucleotide binding]; other site 441771006143 Protein of unknown function (DUF2975); Region: DUF2975; pfam11188 441771006144 Threonine dehydrogenase and related Zn-dependent dehydrogenases [Amino acid transport and metabolism / General function prediction only]; Region: Tdh; COG1063 441771006145 Medium chain reductase/dehydrogenase (MDR)/zinc-dependent alcohol dehydrogenase-like family; Region: MDR; cd05188 441771006146 NAD(P) binding site [chemical binding]; other site 441771006147 Sugar phosphate isomerases/epimerases [Carbohydrate transport and metabolism]; Region: IolE; COG1082 441771006148 Xylose isomerase-like TIM barrel; Region: AP_endonuc_2; pfam01261 441771006149 2-deoxy-scyllo-inosose synthase (DOIS) catalyzes carbocycle formation from D-glucose-6-phosphate to 2-deoxy-scyllo-inosose through a multistep reaction in the biosynthesis of aminoglycoside antibiotics; Region: DOIS; cd08197 441771006150 active site 441771006151 dimer interface [polypeptide binding]; other site 441771006152 metal binding site [ion binding]; metal-binding site 441771006153 ABC-type antimicrobial peptide transport system, permease component [Defense mechanisms]; Region: SalY; COG0577 441771006154 FtsX-like permease family; Region: FtsX; pfam02687 441771006155 FtsX-like permease family; Region: FtsX; pfam02687 441771006156 ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136 441771006157 ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255 441771006158 Walker A/P-loop; other site 441771006159 ATP binding site [chemical binding]; other site 441771006160 Q-loop/lid; other site 441771006161 ABC transporter signature motif; other site 441771006162 Walker B; other site 441771006163 D-loop; other site 441771006164 H-loop/switch region; other site 441771006165 Transcriptional antiterminator [Transcription]; Region: BglG; COG3711 441771006166 HTH domain; Region: HTH_11; pfam08279 441771006167 HTH domain; Region: HTH_11; pfam08279 441771006168 PRD domain; Region: PRD; pfam00874 441771006169 PRD domain; Region: PRD; pfam00874 441771006170 PTS_IIB_bgl_like: the PTS (phosphotransferase system) IIB domain of a family of sensory systems composed of a membrane-bound sugar-sensor (similar to BglF) and a transcription antiterminator (similar to BglG) which regulate expression of genes involved...; Region: PTS_IIB_bgl_like; cd05568 441771006171 active site 441771006172 P-loop; other site 441771006173 phosphorylation site [posttranslational modification] 441771006174 PTS_IIA, PTS system, fructose/mannitol specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_fru; cd00211 441771006175 active site 441771006176 phosphorylation site [posttranslational modification] 441771006177 PTS system ascorbate-specific transporter subunit IIC; Reviewed; Region: ulaA; PRK09410 441771006178 PTS_IIB_ascorbate: subunit IIB of enzyme II (EII) of the L-ascorbate-specific phosphoenolpyruvate:carbohydrate phosphotransferase system (PTS). In this system, EII is an L-ascorbate-specific permease with two cytoplasmic subunits (IIA and IIB) and a...; Region: PTS_IIB_ascorbate; cd05563 441771006179 active site 441771006180 P-loop; other site 441771006181 phosphorylation site [posttranslational modification] 441771006182 PTS_IIA, PTS system, fructose/mannitol specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_fru; cd00211 441771006183 active site 441771006184 phosphorylation site [posttranslational modification] 441771006185 Transaldolase-like fructose-6-phosphate aldolases (FSA) found in bacteria and archaea; Region: Transaldolase_FSA; cd00956 441771006186 active site 441771006187 intersubunit interactions; other site 441771006188 catalytic residue [active] 441771006189 membrane protein; Provisional; Region: PRK14413 441771006190 PUA domain (predicted RNA-binding domain) [Translation, ribosomal structure and biogenesis]; Region: COG5270 441771006191 galactoside O-acetyltransferase; Reviewed; Region: lacA; PRK09527 441771006192 Maltose O-acetyltransferase (MAT) and Galactoside O-acetyltransferase (GAT): MAT and GAT catalyze the CoA-dependent acetylation of the 6-hydroxyl group of their respective sugar substrates. MAT acetylates maltose and glucose exclusively at the C6...; Region: LbH_MAT_GAT; cd03357 441771006193 active site 441771006194 substrate binding site [chemical binding]; other site 441771006195 trimer interface [polypeptide binding]; other site 441771006196 CoA binding site [chemical binding]; other site 441771006197 Dipeptide/tripeptide permease [Amino acid transport and metabolism]; Region: PTR2; COG3104 441771006198 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 441771006199 putative substrate translocation pore; other site 441771006200 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 441771006201 S-adenosylmethionine binding site [chemical binding]; other site 441771006202 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 441771006203 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 441771006204 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 441771006205 Bacterial transcription activator, effector binding domain; Region: AraC_E_bind; smart00871 441771006206 mycofactocin system FadH/OYE family oxidoreductase 2; Region: mycofact_OYE_2; TIGR03997 441771006207 TIM barrel proteins share a structurally conserved phosphate binding motif and in general share an eight beta/alpha closed barrel structure. Specific for this family is the conserved phosphate binding site at the edges of strands 7 and 8. The phosphate...; Region: TIM_phosphate_binding; cl17186 441771006208 phosphate binding site [ion binding]; other site 441771006209 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl19134 441771006210 Predicted transcriptional regulators [Transcription]; Region: SoxR; COG0789 441771006211 Helix-Turn-Helix DNA binding domain of MerR-like transcription regulators; Region: HTH_MerR-like; cd00592 441771006212 DNA binding residues [nucleotide binding] 441771006213 dimer interface [polypeptide binding]; other site 441771006214 CRISPR/Cas system-associated RAMP superfamily protein Cmr6; Region: Cmr6_III-B; cl18978 441771006215 CRISPR/Cas system-associated protein Cmr5; Region: Cmr5_III-B; cl19034 441771006216 CRISPR/Cas system-associated RAMP superfamily protein Cmr4; Region: Cmr4_III-B; cl17440 441771006217 CRISPR/Cas system-associated RAMP superfamily protein Cmr3; Region: Cmr3_III-B; cl12075 441771006218 CRISPR/Cas system-associated protein Cas10; Region: Cas10_III; cd09679 441771006219 CRISPR-associated protein Cas10/Cmr2, subtype III-B; Region: cas_TM1794_Cmr2; TIGR02577 441771006220 metal ion transporter CorA-like divalent cation transporter superfamily; Region: MIT_CorA-like; cl00459 441771006221 CRISPR/Cas system-associated RAMP superfamily protein Cas6; Region: Cas6-I-III; cd09652 441771006222 Predicted AAA-ATPase; Region: AAA-ATPase_like; pfam09820 441771006223 Predicted epimerase, PhzC/PhzF homolog [General function prediction only]; Region: COG0384 441771006224 Diaminopimelate epimerase; Region: DAP_epimerase; cl19724 441771006225 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 441771006226 DNA-binding site [nucleotide binding]; DNA binding site 441771006227 Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain (MocR family) and their eukaryotic orthologs [Transcription / Amino acid transport and metabolism]; Region: ARO8; COG1167 441771006228 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 441771006229 pyridoxal 5'-phosphate binding site [chemical binding]; other site 441771006230 homodimer interface [polypeptide binding]; other site 441771006231 catalytic residue [active] 441771006232 Staygreen protein; Region: Staygreen; pfam12638 441771006233 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 441771006234 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 441771006235 non-specific DNA binding site [nucleotide binding]; other site 441771006236 salt bridge; other site 441771006237 sequence-specific DNA binding site [nucleotide binding]; other site 441771006238 Prolyl oligopeptidase family; Region: Peptidase_S9; cl19144 441771006239 alpha/beta hydrolase fold; Region: Abhydrolase_3; pfam07859 441771006240 N-ethylammeline chlorohydrolase; Provisional; Region: PRK07228 441771006241 TRZ/ATZ family contains enzymes from the atrazine degradation pathway and related hydrolases. Atrazine, a chlorinated herbizide, can be catabolized by a variety of different bacteria. The first three steps of the atrazine dehalogenation pathway are...; Region: ATZ_TRZ_like; cd01298 441771006242 active site 441771006243 putative substrate binding pocket [chemical binding]; other site 441771006244 Sulfate transporter family; Region: Sulfate_transp; cl19250 441771006245 xanthine permease; Region: pbuX; TIGR03173 441771006246 Amino acid transporters [Amino acid transport and metabolism]; Region: PotE; COG0531 441771006247 BadF/BadG/BcrA/BcrD ATPase family; Region: BcrAD_BadFG; cl17271 441771006248 Amino acid permease; Region: AA_permease_2; pfam13520 441771006249 Solute carrier families 5 and 6-like; solute binding domain; Region: SLC5-6-like_sbd; cl00456 441771006250 Na binding site [ion binding]; other site 441771006251 Serine-rich region of AP3B1, clathrin-adaptor complex; Region: SEEEED; cl19208 441771006252 Electron transfer flavoprotein, alpha subunit [Energy production and conversion]; Region: FixB; COG2025 441771006253 The electron transfer flavoprotein (ETF) serves as a specific electron acceptor for various mitochondrial dehydrogenases. ETF transfers electrons to the main respiratory chain via ETF-ubiquinone oxidoreductase. ETF is an heterodimer that consists of an...; Region: ETF_alpha; cd01715 441771006254 Electron transfer flavoprotein FAD-binding domain; Region: ETF_alpha; pfam00766 441771006255 The electron transfer flavoprotein (ETF) serves as a specific electron acceptor for various mitochondrial dehydrogenases. ETF transfers electrons to the main respiratory chain via ETF-ubiquinone oxidoreductase. ETF is an heterodimer that consists of an...; Region: ETF_beta; cd01714 441771006256 Ligand binding site [chemical binding]; other site 441771006257 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 441771006258 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 441771006259 active site 441771006260 Benzoyl-CoA reductase/2-hydroxyglutaryl-CoA dehydratase subunit, BcrC/BadD/HgdB [Amino acid transport and metabolism]; Region: HgdB; COG1775 441771006261 2-hydroxyglutaryl-CoA dehydratase, D-component; Region: HGD-D; pfam06050 441771006262 Benzoyl-CoA reductase/2-hydroxyglutaryl-CoA dehydratase subunit, BcrC/BadD/HgdB [Amino acid transport and metabolism]; Region: HgdB; COG1775 441771006263 2-hydroxyglutaryl-CoA dehydratase, D-component; Region: HGD-D; pfam06050 441771006264 Predicted acyl-CoA transferases/carnitine dehydratase [Energy production and conversion]; Region: CaiB; COG1804 441771006265 This uncharacterized conserved protein belongs to a family of iron-molybdenum cluster-binding proteins that includes NifX, NifB, and NifY, all of which are involved in the synthesis of an iron-molybdenum cofactor (FeMo-co) that binds the active site of...; Region: MTH1175; cd00851 441771006266 MinD superfamily P-loop ATPase containing an inserted ferredoxin domain [Energy production and conversion]; Region: COG1149 441771006267 This protein family's function is unkown. It contains nucleotide binding site. It uses NTP as energy source to transfer electron or ion; Region: Fer4_NifH_child; cd03110 441771006268 P loop nucleotide binding; other site 441771006269 switch II; other site 441771006270 MinD superfamily P-loop ATPase containing an inserted ferredoxin domain [Energy production and conversion]; Region: COG1149 441771006271 This protein family's function is unkown. It contains nucleotide binding site. It uses NTP as energy source to transfer electron or ion; Region: Fer4_NifH_child; cd03110 441771006272 P loop nucleotide binding; other site 441771006273 switch II; other site 441771006274 This uncharacterized conserved protein belongs to a family of iron-molybdenum cluster-binding proteins that includes NifX, NifB, and NifY, all of which are involved in the synthesis of an iron-molybdenum cofactor (FeMo-co) that binds the active site of...; Region: MTH1175; cd00851 441771006275 Flagellar motor protein [Cell motility and secretion]; Region: MotB; COG1360 441771006276 Membrane MotB of proton-channel complex MotA/MotB; Region: MotB_plug; pfam13677 441771006277 Peptidoglycan binding domains similar to the C-terminal domain of outer-membrane protein OmpA; Region: OmpA_C-like; cd07185 441771006278 ligand binding site [chemical binding]; other site 441771006279 flagellar motor protein MotA; Validated; Region: PRK08124 441771006280 Putative cell wall binding repeat 2; Region: CW_binding_2; pfam04122 441771006281 Putative cell wall-binding domain [Cell envelope biogenesis, outer membrane]; Region: LytB; COG2247 441771006282 Putative cell wall binding repeat 2; Region: CW_binding_2; pfam04122 441771006283 Putative cell wall binding repeat 2; Region: CW_binding_2; pfam04122 441771006284 Domain of unknown function (DUF4352); Region: DUF4352; pfam11611 441771006285 Coenzyme PQQ synthesis protein D (PqqD); Region: PqqD; pfam05402 441771006286 OPT oligopeptide transporter protein; Region: OPT; cl14607 441771006287 Xaa-His dipeptidase; Region: aa-his-dipept; TIGR01893 441771006288 M20 Peptidase D has specificity for beta-alanyl-L-histidine dipeptide; Region: M20_pepD; cd03890 441771006289 metal binding site [ion binding]; metal-binding site 441771006290 dimer interface [polypeptide binding]; other site 441771006291 Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl18945 441771006292 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 441771006293 catalytic residue [active] 441771006294 Glycerate kinase [Carbohydrate transport and metabolism]; Region: COG1929 441771006295 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 441771006296 short chain dehydrogenase; Region: adh_short; pfam00106 441771006297 NAD(P) binding site [chemical binding]; other site 441771006298 active site 441771006299 ABC-type Na+ efflux pump, permease component [Energy production and conversion / Inorganic ion transport and metabolism]; Region: NatB; COG1668 441771006300 YhgE/Pip N-terminal domain; Region: pip_yhgE_Nterm; cl19580 441771006301 ABC-2 family transporter protein; Region: ABC2_membrane_2; pfam12679 441771006302 ABC-type Na+ transport system, ATPase component [Energy production and conversion / Inorganic ion transport and metabolism]; Region: NatA; COG4555 441771006303 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 441771006304 Walker A/P-loop; other site 441771006305 ATP binding site [chemical binding]; other site 441771006306 Q-loop/lid; other site 441771006307 ABC transporter signature motif; other site 441771006308 Walker B; other site 441771006309 D-loop; other site 441771006310 H-loop/switch region; other site 441771006311 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 441771006312 Coenzyme A binding pocket [chemical binding]; other site 441771006313 Transcriptional regulators [Transcription]; Region: MarR; COG1846 441771006314 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cl17220 441771006315 Protein of unknown function (DUF2809); Region: DUF2809; pfam10990 441771006316 The URO-D _like protein superfamily includes bacterial and eukaryotic uroporphyrinogen decarboxylases (URO-D), coenzyme M methyltransferases and other putative bacterial methyltransferases. Uroporphyrinogen decarboxylase (URO-D) decarboxylates the four...; Region: URO-D_like; cd03465 441771006317 Predicted dehydrogenase [General function prediction only]; Region: COG0579 441771006318 hydroxyglutarate oxidase; Provisional; Region: PRK11728; cl19156 441771006319 BFD-like [2Fe-2S] binding domain; Region: Fer2_BFD; pfam04324 441771006320 Helix-Turn-Helix DNA binding domain of the BmrR transcription regulator; Region: HTH_BmrR; cd01107 441771006321 Predicted transcriptional regulators [Transcription]; Region: SoxR; COG0789 441771006322 DNA binding residues [nucleotide binding] 441771006323 drug binding residues [chemical binding]; other site 441771006324 dimer interface [polypeptide binding]; other site 441771006325 Bacterial transcription activator, effector binding domain; Region: AraC_E_bind; smart00871 441771006326 Amino acid permease; Region: AA_permease_2; pfam13520 441771006327 Transmembrane amino acid transporter protein; Region: Aa_trans; cl17468 441771006328 Macro domain, Appr-1"-pase_like family. The macro domain is a high-affinity ADP-ribose binding module found in a variety of proteins as a stand-alone domain or in combination with other domains like in histone macroH2A and some PARPs (poly...; Region: Macro_Appr_pase_like; cd02908 441771006329 putative ADP-ribose binding site [chemical binding]; other site 441771006330 putative active site [active] 441771006331 Protein of unknown function (DUF1294); Region: DUF1294; pfam06961 441771006332 Transcriptional regulators [Transcription]; Region: MarR; COG1846 441771006333 helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347 441771006334 putative DNA binding site [nucleotide binding]; other site 441771006335 putative Zn2+ binding site [ion binding]; other site 441771006336 TIGR03987 family protein; Region: TIGR03987 441771006337 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 441771006338 Walker A/P-loop; other site 441771006339 ATP binding site [chemical binding]; other site 441771006340 4-methyl-5-beta-hydroxyethylthiazole (Thz) kinase catalyzes the phosphorylation of the hydroxylgroup of Thz. A reaction that allows cells to recycle Thz into the thiamine biosynthesis pathway, as an alternative to its synthesis from cysteine, tyrosine...; Region: THZ_kinase; cd01170 441771006341 substrate binding site [chemical binding]; other site 441771006342 multimerization interface [polypeptide binding]; other site 441771006343 ATP binding site [chemical binding]; other site 441771006344 Thiamine-precursor transporter protein (ThiW); Region: ThiW; pfam09512 441771006345 Acetyltransferase (GNAT) domain; Region: Acetyltransf_10; pfam13673 441771006346 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 441771006347 Coenzyme A binding pocket [chemical binding]; other site 441771006348 Metallo-beta-lactamase superfamily; Region: Lactamase_B; smart00849 441771006349 Mor transcription activator family; Region: Mor; cl02360 441771006350 AAA domain; Region: AAA_26; pfam13500 441771006351 dithiobiotin synthetase; Reviewed; Region: bioD; PRK00090 441771006352 biotin synthase; Region: bioB; TIGR00433 441771006353 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 441771006354 FeS/SAM binding site; other site 441771006355 Biotin and Thiamin Synthesis associated domain; Region: BATS; pfam06968 441771006356 Uncharacterized conserved protein [General function prediction only]; Region: BioY; COG1268 441771006357 hypothetical protein; Provisional; Region: PRK09272 441771006358 Transcriptional regulators [Transcription]; Region: MarR; COG1846 441771006359 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 441771006360 putative DNA binding site [nucleotide binding]; other site 441771006361 putative Zn2+ binding site [ion binding]; other site 441771006362 Domain of Unknown Function with PDB structure (DUF3862); Region: DUF3862; pfam12978 441771006363 Creatinase/Prolidase N-terminal domain; Region: Creatinase_N; pfam01321 441771006364 Xaa-Pro aminopeptidase [Amino acid transport and metabolism]; Region: PepP; COG0006 441771006365 Creatinase/Prolidase N-terminal domain; Region: Creatinase_N; pfam01321 441771006366 A family including aminopeptidase P, aminopeptidase M, and prolidase. Also known as metallopeptidase family M24. This family of enzymes is able to cleave amido-, imido- and amidino-containing bonds. Members exibit relatively narrow substrate specificity...; Region: APP_MetAP; cl00279 441771006367 active site 441771006368 Dipeptide/tripeptide permease [Amino acid transport and metabolism]; Region: PTR2; COG3104 441771006369 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 441771006370 putative substrate translocation pore; other site 441771006371 Domain of Unknown Function (DUF1599); Region: DUF1599; pfam07659 441771006372 YmaF family; Region: YmaF; pfam12788 441771006373 Predicted choloylglycine hydrolase [General function prediction only]; Region: COG4927 441771006374 Choloylglycine hydrolase (CGH)_like. This family of choloylglycine hydrolase-like proteins includes conjugated bile acid hydrolase (CBAH), penicillin V acylase (PVA), acid ceramidase (AC), and N-acylethanolamine-hydrolyzing acid amidase (NAAA) which...; Region: Ntn_CGH_like; cd01935 441771006375 active site 441771006376 Multimeric flavodoxin WrbA [General function prediction only]; Region: WrbA; COG0655 441771006377 Terminase small subunit; Region: Terminase_2; cl01513 441771006378 YmaF family; Region: YmaF; pfam12788 441771006379 hypothetical protein; Provisional; Region: PRK05802 441771006380 FAD/NAD binding domain (electron transfer subunit) of dihydroorotate dehydrogenase-like proteins. Dihydroorotate dehydrogenases (DHODs) catalyze the only redox reaction in pyrimidine de novo biosynthesis. They catalyze the oxidation of (S)-dihydroorotate...; Region: DHOD_e_trans_like; cd06192 441771006381 FAD binding pocket [chemical binding]; other site 441771006382 FAD binding motif [chemical binding]; other site 441771006383 phosphate binding motif [ion binding]; other site 441771006384 beta-alpha-beta structure motif; other site 441771006385 NAD binding pocket [chemical binding]; other site 441771006386 Iron coordination center [ion binding]; other site 441771006387 Spo0E like sporulation regulatory protein; Region: SpoOE-like; pfam09388 441771006388 Protein of unknown function (DUF1307); Region: DUF1307; cl01981 441771006389 methionine sulfoxide reductase B; Provisional; Region: PRK00222 441771006390 Superoxide dismutase [Inorganic ion transport and metabolism]; Region: SodA; COG0605 441771006391 Iron/manganese superoxide dismutases, alpha-hairpin domain; Region: Sod_Fe_N; pfam00081 441771006392 Iron/manganese superoxide dismutases, C-terminal domain; Region: Sod_Fe_C; pfam02777 441771006393 ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132 441771006394 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 441771006395 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 441771006396 Walker A/P-loop; other site 441771006397 ATP binding site [chemical binding]; other site 441771006398 Q-loop/lid; other site 441771006399 ABC transporter signature motif; other site 441771006400 Walker B; other site 441771006401 D-loop; other site 441771006402 H-loop/switch region; other site 441771006403 ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132 441771006404 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 441771006405 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 441771006406 Walker A/P-loop; other site 441771006407 ATP binding site [chemical binding]; other site 441771006408 Q-loop/lid; other site 441771006409 ABC transporter signature motif; other site 441771006410 Walker B; other site 441771006411 D-loop; other site 441771006412 H-loop/switch region; other site 441771006413 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 441771006414 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 441771006415 ABC-2 family transporter protein; Region: ABC2_membrane_4; pfam12730 441771006416 ABC-2 family transporter protein; Region: ABC2_membrane_4; pfam12730 441771006417 ABC-type multidrug transport system, ATPase component [Defense mechanisms]; Region: CcmA; COG1131 441771006418 ATP-binding cassette domain of the bacitracin-resistance transporter; Region: ABC_BcrA_bacitracin_resist; cd03268 441771006419 Walker A/P-loop; other site 441771006420 ATP binding site [chemical binding]; other site 441771006421 Q-loop/lid; other site 441771006422 ABC transporter signature motif; other site 441771006423 Walker B; other site 441771006424 D-loop; other site 441771006425 H-loop/switch region; other site 441771006426 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 441771006427 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 441771006428 dimer interface [polypeptide binding]; other site 441771006429 phosphorylation site [posttranslational modification] 441771006430 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 441771006431 ATP binding site [chemical binding]; other site 441771006432 Mg2+ binding site [ion binding]; other site 441771006433 G-X-G motif; other site 441771006434 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 441771006435 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 441771006436 active site 441771006437 phosphorylation site [posttranslational modification] 441771006438 intermolecular recognition site; other site 441771006439 dimerization interface [polypeptide binding]; other site 441771006440 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 441771006441 DNA binding site [nucleotide binding] 441771006442 DEDDh 3'-5' exonuclease domain of Caenorhabditis elegans ERI-1, human 3' exonuclease, and similar proteins; Region: ERI-1_3'hExo_like; cd06133 441771006443 active site 441771006444 catalytic site [active] 441771006445 substrate binding site [chemical binding]; other site 441771006446 Stress responsive A/B Barrel Domain; Region: Dabb; smart00886 441771006447 Metal-dependent hydrolases of the beta-lactamase superfamily II [General function prediction only]; Region: COG1237 441771006448 Polypeptide or peptide deformylase; a family of metalloenzymes that catalyzes the removal of the N-terminal formyl group in a growing polypeptide chain following translation initiation during protein synthesis in prokaryotes. These enzymes utilize Fe(II)...; Region: Pep_deformylase; cd00487 441771006449 active site 441771006450 catalytic residues [active] 441771006451 metal binding site [ion binding]; metal-binding site 441771006452 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 441771006453 non-specific DNA binding site [nucleotide binding]; other site 441771006454 salt bridge; other site 441771006455 sequence-specific DNA binding site [nucleotide binding]; other site 441771006456 transglutaminase; Provisional; Region: tgl; PRK03187 441771006457 oxidoreductase; Provisional; Region: PRK06128 441771006458 classical (c) SDR, subgroup 1; Region: SDR_c1; cd05355 441771006459 NAD binding site [chemical binding]; other site 441771006460 metal binding site [ion binding]; metal-binding site 441771006461 active site 441771006462 Domain of Unknown Function with PDB structure (DUF3862); Region: DUF3862; pfam12978 441771006463 Dolichyl-phosphate-mannose-protein mannosyltransferase; Region: PMT_2; cl19158 441771006464 RNA polymerase sigma factor, sigma-70 family; Region: sigma70-ECF; TIGR02937 441771006465 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 441771006466 Amino acid transporters [Amino acid transport and metabolism]; Region: PotE; COG0531 441771006467 Spore germination protein; Region: Spore_permease; cl17796 441771006468 Site-specific DNA methylase [DNA replication, recombination, and repair]; Region: Dcm; COG0270 441771006469 cofactor binding site; other site 441771006470 DNA binding site [nucleotide binding] 441771006471 substrate interaction site [chemical binding]; other site 441771006472 Nucleotidyltransferase (NT) domain of ClassII CCA-adding enzymes; Region: NT_ClassII-CCAase; cd05398 441771006473 tRNA CCA-pyrophosphorylase; Provisional; Region: PRK13299 441771006474 active site 441771006475 NTP binding site [chemical binding]; other site 441771006476 metal binding triad [ion binding]; metal-binding site 441771006477 Probable RNA and SrmB- binding site of polymerase A; Region: PolyA_pol_RNAbd; pfam12627 441771006478 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 441771006479 Zn2+ binding site [ion binding]; other site 441771006480 Mg2+ binding site [ion binding]; other site 441771006481 tRNA nucleotidyltransferase domain 2 putative; Region: tRNA_NucTran2_2; pfam13735 441771006482 Predicted nucleotidyltransferase; Region: Nuc-transf; cl01417 441771006483 Src Homology 3 domain superfamily; Region: SH3; cl17036 441771006484 Transcriptional regulator PadR-like family; Region: PadR; cl17335 441771006485 NfeD-like C-terminal, partner-binding; Region: NfeD; cl00686 441771006486 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 441771006487 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 441771006488 dimer interface [polypeptide binding]; other site 441771006489 phosphorylation site [posttranslational modification] 441771006490 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 441771006491 ATP binding site [chemical binding]; other site 441771006492 Mg2+ binding site [ion binding]; other site 441771006493 G-X-G motif; other site 441771006494 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 441771006495 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 441771006496 active site 441771006497 phosphorylation site [posttranslational modification] 441771006498 intermolecular recognition site; other site 441771006499 dimerization interface [polypeptide binding]; other site 441771006500 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 441771006501 DNA binding site [nucleotide binding] 441771006502 UBA/TS-N domain; Region: UBA; pfam00627 441771006503 Transcription factor homologous to NACalpha-BTF3 [Transcription]; Region: EGD2; COG1308 441771006504 hypothetical protein; Provisional; Region: PRK06921 441771006505 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 441771006506 Walker A motif; other site 441771006507 ATP binding site [chemical binding]; other site 441771006508 Walker B motif; other site 441771006509 arginine finger; other site 441771006510 Glucose inhibited division protein A; Region: GIDA; pfam01134 441771006511 tRNA (uracil-5-)-methyltransferase Gid; Reviewed; Region: PRK05335 441771006512 Adenylsuccinate lyase (ASL)_subgroup 2; Region: Adenylsuccinate_lyase_2; cd03302 441771006513 Adenylosuccinate lyase [Nucleotide transport and metabolism]; Region: PurB; COG0015 441771006514 tetramer interface [polypeptide binding]; other site 441771006515 active site 441771006516 Domain of unknown function (DUF378); Region: DUF378; cl00943 441771006517 Histidine-containing phosphocarrier protein (HPr)-like proteins. HPr is a central component of the bacterial phosphoenolpyruvate sugar phosphotransferase system (PTS). The PTS catalyses the phosphorylation of sugar substrates during their translocation...; Region: PTS-HPr_like; cd00367 441771006518 dimerization domain swap beta strand [polypeptide binding]; other site 441771006519 regulatory protein interface [polypeptide binding]; other site 441771006520 active site 441771006521 regulatory phosphorylation site [posttranslational modification]; other site 441771006522 aspartate aminotransferase; Provisional; Region: PRK05764 441771006523 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 441771006524 pyridoxal 5'-phosphate binding site [chemical binding]; other site 441771006525 homodimer interface [polypeptide binding]; other site 441771006526 catalytic residue [active] 441771006527 4-amino-4-deoxy-L-arabinose-phosphoundecaprenol flippase subunit ArnF; Provisional; Region: PRK02971 441771006528 Permeases of the drug/metabolite transporter (DMT) superfamily [Carbohydrate transport and metabolism / Amino acid transport and metabolism / General function prediction only]; Region: RhaT; COG0697 441771006529 UbiA family of prenyltransferases (PTases), Unknown subgroup; Region: PT_UbiA_2; cd13963 441771006530 putative active site [active] 441771006531 Stage V sporulation protein S (SpoVS); Region: SpoVS; pfam04232 441771006532 phosphodiesterase; Provisional; Region: PRK12704 441771006533 KH domain; Region: KH_1; pfam00013 441771006534 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 441771006535 Zn2+ binding site [ion binding]; other site 441771006536 Mg2+ binding site [ion binding]; other site 441771006537 recombinase A; Provisional; Region: recA; PRK09354 441771006538 RecA is a bacterial enzyme which has roles in homologous recombination, DNA repair, and the induction of the SOS response. RecA couples ATP hydrolysis to DNA strand exchange; Region: recA; cd00983 441771006539 hexamer interface [polypeptide binding]; other site 441771006540 Walker A motif; other site 441771006541 ATP binding site [chemical binding]; other site 441771006542 Walker B motif; other site 441771006543 CDP-alcohol phosphatidyltransferase; Region: CDP-OH_P_transf; cl00453 441771006544 2-methylthioadenine synthetase [Translation, ribosomal structure and biogenesis]; Region: MiaB; COG0621 441771006545 Uncharacterized protein family UPF0004; Region: UPF0004; pfam00919 441771006546 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 441771006547 FeS/SAM binding site; other site 441771006548 Domain of unknown function (DUF4117); Region: DUF4117; pfam13491 441771006549 Tetraspanin family; Region: Tetraspannin; pfam00335 441771006550 DNA segregation ATPase FtsK/SpoIIIE and related proteins [Cell division and chromosome partitioning]; Region: FtsK; COG1674 441771006551 FtsK/SpoIIIE family; Region: FtsK_SpoIIIE; pfam01580 441771006552 Ftsk gamma domain; Region: Ftsk_gamma; pfam09397 441771006553 Caseinolytic protease (ClpP) is an ATP-dependent protease; Region: Clp_protease_like; cl15763 441771006554 active site 441771006555 aspartate kinase I; Reviewed; Region: PRK08210 441771006556 Amino Acid Kinases (AAK) superfamily, catalytic domain; present in such enzymes like N-acetylglutamate kinase (NAGK), carbamate kinase (CK), aspartokinase (AK), glutamate-5-kinase (G5K) and UMP kinase (UMPK). The AAK superfamily includes kinases that...; Region: AAK; cl00452 441771006557 nucleotide binding site [chemical binding]; other site 441771006558 substrate binding site [chemical binding]; other site 441771006559 ACT domains are commonly involved in specifically binding an amino acid or other small ligand leading to regulation of the enzyme; Region: ACT; cl09141 441771006560 ACT domains of the diaminopimelate-sensitive aspartokinase (AK) isoenzyme AKI; Region: ACT_AKi-DapG-BS_2; cd04937 441771006561 sporulation protein, YlmC/YmxH family; Region: spore_YlmC_YmxH; TIGR02888 441771006562 Predicted Zn-dependent peptidases [General function prediction only]; Region: PqqL; COG0612 441771006563 Insulinase (Peptidase family M16); Region: Peptidase_M16; pfam00675 441771006564 Peptidase M16 inactive domain; Region: Peptidase_M16_C; pfam05193 441771006565 polynucleotide phosphorylase/polyadenylase; Provisional; Region: PRK11824 441771006566 Polyribonucleotide nucleotidyltransferase, repeat 1; Region: RNase_PH_PNPase_1; cd11363 441771006567 RNase E interface [polypeptide binding]; other site 441771006568 trimer interface [polypeptide binding]; other site 441771006569 Polyribonucleotide nucleotidyltransferase, RNA binding domain; Region: PNPase; pfam03726 441771006570 Polyribonucleotide nucleotidyltransferase, repeat 2; Region: RNase_PH_PNPase_2; cd11364 441771006571 RNase E interface [polypeptide binding]; other site 441771006572 trimer interface [polypeptide binding]; other site 441771006573 active site 441771006574 Polynucleotide phosphorylase (PNPase) K homology RNA-binding domain (KH). PNPase is a polyribonucleotide nucleotidyl transferase that degrades mRNA in prokaryotes and plant chloroplasts. The C-terminal region of PNPase contains domains homologous to...; Region: PNPase_KH; cd02393 441771006575 putative nucleic acid binding region [nucleotide binding]; other site 441771006576 G-X-X-G motif; other site 441771006577 S1_PNPase: Polynucleotide phosphorylase (PNPase), ), S1-like RNA-binding domain. PNPase is a polyribonucleotide nucleotidyl transferase that degrades mRNA. It is a trimeric multidomain protein. The C-terminus contains the S1 domain which binds ssRNA; Region: S1_PNPase; cd04472 441771006578 RNA binding site [nucleotide binding]; other site 441771006579 domain interface; other site 441771006580 Ribosomal protein S15 (prokaryotic)_S13 (eukaryotic) binds the central domain of 16S rRNA and is required for assembly of the small ribosomal subunit and for intersubunit association, thus representing a key element in the assembly of the whole ribosome; Region: Ribosomal_S15p_S13e; cd00353 441771006581 16S/18S rRNA binding site [nucleotide binding]; other site 441771006582 S13e-L30e interaction site [polypeptide binding]; other site 441771006583 25S rRNA binding site [nucleotide binding]; other site 441771006584 bifunctional riboflavin kinase/FMN adenylyltransferase; Reviewed; Region: PRK05627 441771006585 FAD synthetase, N-terminal domain of the bifunctional enzyme; Region: FAD_synthetase_N; cd02064 441771006586 active site 441771006587 Riboflavin kinase; Region: Flavokinase; smart00904 441771006588 tRNA pseudouridine synthase B; Provisional; Region: truB; PRK00130 441771006589 Pseudouridine synthase, Escherichia coli TruB like; Region: PseudoU_synth_EcTruB; cd02573 441771006590 RNA binding site [nucleotide binding]; other site 441771006591 active site 441771006592 Exopolyphosphatase-related proteins [General function prediction only]; Region: COG0618 441771006593 DHH family; Region: DHH; pfam01368 441771006594 DHHA1 domain; Region: DHHA1; pfam02272 441771006595 ribosome-binding factor A; Validated; Region: rbfA; PRK00521 441771006596 translation initiation factor IF-2; Validated; Region: infB; PRK05306 441771006597 Translation initiation factor IF-2, N-terminal region; Region: IF2_N; pfam04760 441771006598 Translation initiation factor IF-2, N-terminal region; Region: IF2_N; pfam04760 441771006599 Initiation Factor 2 (IF2)/ eukaryotic Initiation Factor 5B (eIF5B) family; Region: IF2_eIF5B; cd01887 441771006600 G1 box; other site 441771006601 putative GEF interaction site [polypeptide binding]; other site 441771006602 GTP/Mg2+ binding site [chemical binding]; other site 441771006603 Switch I region; other site 441771006604 G2 box; other site 441771006605 G3 box; other site 441771006606 Switch II region; other site 441771006607 G4 box; other site 441771006608 G5 box; other site 441771006609 This family represents the domain II of bacterial Initiation Factor 2 (IF2) and its eukaryotic mitochondrial homologue mtIF2. IF2, the largest initiation factor is an essential GTP binding protein. In E. coli three natural forms of IF2 exist in the cell; Region: IF2_mtIF2_II; cd03702 441771006610 Translation-initiation factor 2; Region: IF-2; pfam11987 441771006611 mtIF2_IVc: this family represents the C2 subdomain of domain IV of mitochondrial translation initiation factor 2 (mtIF2) which adopts a beta-barrel fold displaying a high degree of structural similarity with domain II of the translation elongation factor...; Region: mtIF2_IVc; cd03692 441771006612 ribosomal protein L7Ae family protein; Provisional; Region: PRK05583 441771006613 Ylxr homologs; group of conserved hypothetical bacterial proteins of unknown function; structure revealed putative RNA binding cleft; proteins are encoded by an operon that includes other proteins involved in transcription and/or translation; Region: YlxR; cd00279 441771006614 putative RNA binding cleft [nucleotide binding]; other site 441771006615 transcription elongation factor NusA; Provisional; Region: nusA; PRK12327 441771006616 NusA N-terminal domain; Region: NusA_N; pfam08529 441771006617 S1_NusA: N-utilizing substance A protein (NusA), S1-like RNA-binding domain. S1-like RNA-binding domains are found in a wide variety of RNA-associated proteins. NusA is a transcription elongation factor containing an N-terminal catalytic domain and three...; Region: S1_NusA; cd04455 441771006618 RNA binding site [nucleotide binding]; other site 441771006619 homodimer interface [polypeptide binding]; other site 441771006620 NusA_K homology RNA-binding domain (KH). NusA is an essential multifunctional transcription elongation factor that is universally conserved among prokaryotes and archaea. NusA anti-termination function plays an important role in the expression of...; Region: NusA_KH; cd02134 441771006621 G-X-X-G motif; other site 441771006622 NusA_K homology RNA-binding domain (KH). NusA is an essential multifunctional transcription elongation factor that is universally conserved among prokaryotes and archaea. NusA anti-termination function plays an important role in the expression of...; Region: NusA_KH; cd02134 441771006623 G-X-X-G motif; other site 441771006624 Sm and related proteins; Region: Sm_like; cl00259 441771006625 Bacillus subtilis YxlS-like, C-terminal domain; Region: YlxS_C; cd01734 441771006626 putative oligomer interface [polypeptide binding]; other site 441771006627 putative RNA binding site [nucleotide binding]; other site 441771006628 DNA polymerase III PolC; Validated; Region: polC; PRK00448 441771006629 DNA polymerase III polC-type N-terminus I; Region: DNA_pol3_a_NI; pfam14480 441771006630 DNA polymerase III polC-type N-terminus II; Region: DNA_pol3_a_NII; pfam11490 441771006631 polC_OBF: A subfamily of OB folds corresponding to the N-terminal OB-fold nucleic acid binding domain of Bacillus subtilis type C replicative DNA polymerase III alpha subunit (polC). Replication in B. subtilis and Staphylococcus aureus requires two...; Region: polC_OBF; cd04484 441771006632 generic binding surface II; other site 441771006633 generic binding surface I; other site 441771006634 Polymerase and Histidinol Phosphatase domain of alpha-subunit of bacterial polymerase III at PolC gene; Region: PHP_PolIIIA_POLC; cd07435 441771006635 active site 441771006636 putative PHP Thumb interface [polypeptide binding]; other site 441771006637 DEDDh 3'-5' exonuclease domain family; Region: DEDDh; cd06127 441771006638 active site 441771006639 catalytic site [active] 441771006640 substrate binding site [chemical binding]; other site 441771006641 Bacterial DNA polymerase III alpha subunit; Region: DNA_pol3_alpha; pfam07733 441771006642 Helix-hairpin-helix motif; Region: HHH_6; pfam14579 441771006643 4-hydroxy-3-methylbut-2-en-1-yl diphosphate synthase; Reviewed; Region: ispG; PRK00366 441771006644 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate synthase; Region: ispG_gcpE; TIGR00612 441771006645 RIP metalloprotease RseP; Region: TIGR00054 441771006646 RseP-like Site-2 proteases (S2P), zinc metalloproteases (MEROPS family M50A), cleave transmembrane domains of substrate proteins, regulating intramembrane proteolysis (RIP) of diverse signal transduction mechanisms. In Escherichia coli, the S2P homolog...; Region: S2P-M50_PDZ_RseP-like; cd06163 441771006647 active site 441771006648 PDZ domain of bacterial and plant zinc metalloprotases, presumably membrane-associated or integral membrane proteases, which may be involved in signalling and regulatory mechanisms. May be responsible for substrate recognition and/or binding, as most PDZ...; Region: PDZ_metalloprotease; cd00989 441771006649 putative substrate binding region [chemical binding]; other site 441771006650 1-deoxy-D-xylulose 5-phosphate reductoisomerase; Provisional; Region: PRK05447 441771006651 1-deoxy-D-xylulose 5-phosphate reductoisomerase; Region: DXP_reductoisom; pfam02670 441771006652 1-deoxy-D-xylulose 5-phosphate reductoisomerase C-terminal; Region: DXP_redisom_C; pfam08436 441771006653 DXP reductoisomerase C-terminal domain; Region: DXPR_C; pfam13288 441771006654 Domain of unknown function DUF20; Region: UPF0118; cl00465 441771006655 CDP-diglyceride synthetase [Lipid metabolism]; Region: CdsA; COG0575 441771006656 Cis (Z)-Isoprenyl Diphosphate Synthases; Region: Cis_IPPS; cd00475 441771006657 active site 441771006658 dimer interface [polypeptide binding]; other site 441771006659 Ribosome recycling factor (RRF). Ribosome recycling factor dissociates the posttermination complex, composed of the ribosome, deacylated tRNA, and mRNA, after termination of translation. Thus ribosomes are "recycled" and ready for another...; Region: RRF; cd00520 441771006660 hinge region; other site 441771006661 UMP kinase (UMPK)-Ec, the microbial/chloroplast uridine monophosphate kinase (uridylate kinase) enzyme that catalyzes UMP phosphorylation and plays a key role in pyrimidine nucleotide biosynthesis; regulation of this process is via feed-back control and...; Region: AAK_UMPK-PyrH-Ec; cd04254 441771006662 putative nucleotide binding site [chemical binding]; other site 441771006663 uridine monophosphate binding site [chemical binding]; other site 441771006664 homohexameric interface [polypeptide binding]; other site 441771006665 elongation factor Ts; Provisional; Region: tsf; PRK09377 441771006666 UBA/TS-N domain; Region: UBA; pfam00627 441771006667 Ribosomal protein S2 (RPS2), involved in formation of the translation initiation complex, where it might contact the messenger RNA and several components of the ribosome. It has been shown that in Escherichia coli RPS2 is essential for the binding of...; Region: RPS2; cd01425 441771006668 rRNA interaction site [nucleotide binding]; other site 441771006669 S8 interaction site; other site 441771006670 putative laminin-1 binding site; other site 441771006671 transcriptional repressor CodY; Validated; Region: PRK04158 441771006672 CodY GAF-like domain; Region: CodY; pfam06018 441771006673 CodY helix-turn-helix domain; Region: HTH_CodY; pfam08222 441771006674 DNA topoisomerase I; Validated; Region: PRK05582 441771006675 TOPRIM_TopoIA_TopoI: The topoisomerase-primase (TORPIM) domain found in members of the type IA family of DNA topoisomerases (Topo IA) similar to Escherichia coli DNA topoisomerase I. Type IA DNA topoisomerases remove (relax) negative supercoils in the...; Region: TOPRIM_TopoIA_TopoI; cd03363 441771006676 active site 441771006677 interdomain interaction site; other site 441771006678 putative metal-binding site [ion binding]; other site 441771006679 nucleotide binding site [chemical binding]; other site 441771006680 DNA Topoisomerase, subtype IA; DNA-binding, ATP-binding and catalytic domain of bacterial DNA topoisomerases I and III, and eukaryotic DNA topoisomerase III and eubacterial and archael reverse gyrases. Topoisomerases clevage single or double stranded DNA...; Region: TOP1Ac; cd00186 441771006681 domain I; other site 441771006682 DNA binding groove [nucleotide binding] 441771006683 phosphate binding site [ion binding]; other site 441771006684 domain II; other site 441771006685 domain III; other site 441771006686 nucleotide binding site [chemical binding]; other site 441771006687 catalytic site [active] 441771006688 domain IV; other site 441771006689 Topoisomerase DNA binding C4 zinc finger; Region: zf-C4_Topoisom; pfam01396 441771006690 Topoisomerase DNA binding C4 zinc finger; Region: zf-C4_Topoisom; pfam01396 441771006691 Topoisomerase DNA binding C4 zinc finger; Region: zf-C4_Topoisom; pfam01396 441771006692 Predicted Rossmann fold nucleotide-binding protein involved in DNA uptake [DNA replication, recombination, and repair / Intracellular trafficking and secretion]; Region: Smf; COG0758 441771006693 DNA recombination-mediator protein A; Region: DNA_processg_A; pfam02481 441771006694 Predicted ATPase with chaperone activity [Posttranslational modification, protein turnover, chaperones]; Region: COG0606 441771006695 Subunit ChlI of Mg-chelatase; Region: ChlI; pfam13541 441771006696 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 441771006697 Walker A motif; other site 441771006698 ATP binding site [chemical binding]; other site 441771006699 Walker B motif; other site 441771006700 Magnesium chelatase, subunit ChlI; Region: Mg_chelatase_2; pfam13335 441771006701 hypothetical protein; Reviewed; Region: PRK12497 441771006702 Bacterial Ribonuclease HII-like; Region: RNase_HII_bacteria_HII_like; cd07182 441771006703 RNA/DNA hybrid binding site [nucleotide binding]; other site 441771006704 active site 441771006705 GTPase YlqF; Reviewed; Region: rbgA; PRK09563 441771006706 Circularly permuted YlqF GTPase; Region: YlqF; cd01856 441771006707 GTP/Mg2+ binding site [chemical binding]; other site 441771006708 G4 box; other site 441771006709 G5 box; other site 441771006710 G1 box; other site 441771006711 Switch I region; other site 441771006712 G2 box; other site 441771006713 G3 box; other site 441771006714 Switch II region; other site 441771006715 signal peptidase I, bacterial type; Region: sigpep_I_bact; TIGR02227 441771006716 The S26 Type I signal peptidase (SPase; LepB; leader peptidase B; leader peptidase I; EC 3.4.21.89) family members are essential membrane-bound serine proteases that function to cleave the amino-terminal signal peptide extension from proteins that are...; Region: S26_SPase_I; cd06530 441771006717 Catalytic site [active] 441771006718 The S24, S26 LexA/signal peptidase superfamily contains LexA-related and type I signal peptidase families. The S24 LexA protein domains include: the lambda repressor CI/C2 family and related bacterial prophage repressor proteins; LexA (EC 3.4.21.88), the...; Region: Peptidase_S24_S26; cl10465 441771006719 50S ribosomal protein L19; Provisional; Region: rplS; PRK05338 441771006720 tRNA (guanine-N(1)-)-methyltransferase; Reviewed; Region: trmD; PRK00026 441771006721 16S rRNA-processing protein RimM; Provisional; Region: rimM; PRK00122 441771006722 RimM N-terminal domain; Region: RimM; pfam01782 441771006723 PRC-barrel domain; Region: PRC; pfam05239 441771006724 hypothetical protein; Provisional; Region: PRK00468 441771006725 30S ribosomal protein S16; Reviewed; Region: rpsP; PRK00040 441771006726 signal recognition particle protein; Provisional; Region: PRK10867 441771006727 SRP54-type protein, helical bundle domain; Region: SRP54_N; smart00963 441771006728 The signal recognition particle (SRP) mediates the transport to or across the plasma membrane in bacteria and the endoplasmic reticulum in eukaryotes. SRP recognizes N-terminal sighnal sequences of newly synthesized polypeptides at the ribosome. The...; Region: SRP; cd03115 441771006729 P loop; other site 441771006730 GTP binding site [chemical binding]; other site 441771006731 Signal peptide binding domain; Region: SRP_SPB; pfam02978 441771006732 putative DNA-binding protein; Validated; Region: PRK00118 441771006733 RNA polymerase sigma factor, sigma-70 family; Region: sigma70-ECF; TIGR02937 441771006734 signal recognition particle-docking protein FtsY; Provisional; Region: PRK10416 441771006735 SRP54-type protein, helical bundle domain; Region: SRP54_N; pfam02881 441771006736 SRP54-type protein, GTPase domain; Region: SRP54; smart00962 441771006737 chromosome segregation protein SMC, common bacterial type; Region: SMC_prok_B; TIGR02168 441771006738 ATP-binding cassette domain of barmotin, a member of the SMC protein family; Region: ABC_SMC_barmotin; cd03278 441771006739 Walker A/P-loop; other site 441771006740 ATP binding site [chemical binding]; other site 441771006741 Q-loop/lid; other site 441771006742 Protein of unknown function (DUF1202); Region: DUF1202; pfam06717 441771006743 SMC proteins Flexible Hinge Domain; Region: SMC_hinge; smart00968 441771006744 ATP-binding cassette domain of barmotin, a member of the SMC protein family; Region: ABC_SMC_barmotin; cd03278 441771006745 Q-loop/lid; other site 441771006746 ABC transporter signature motif; other site 441771006747 Walker B; other site 441771006748 D-loop; other site 441771006749 H-loop/switch region; other site 441771006750 Radical SAM superfamily; Region: Radical_SAM; pfam04055 441771006751 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 441771006752 FeS/SAM binding site; other site 441771006753 ribonuclease III; Reviewed; Region: rnc; PRK00102 441771006754 RIBOc. Ribonuclease III C terminal domain. This group consists of eukaryotic, bacterial and archeal ribonuclease III (RNAse III) proteins. RNAse III is a double stranded RNA-specific endonuclease. Prokaryotic RNAse III is important in...; Region: RIBOc; cd00593 441771006755 dimerization interface [polypeptide binding]; other site 441771006756 active site 441771006757 metal binding site [ion binding]; metal-binding site 441771006758 Double-stranded RNA binding motif. Binding is not sequence specific but is highly specific for double stranded RNA. Found in a variety of proteins including dsRNA dependent protein kinase PKR, RNA helicases, Drosophila staufen protein, E. coli RNase III; Region: DSRM; cd00048 441771006759 dsRNA binding site [nucleotide binding]; other site 441771006760 acyl carrier protein; Provisional; Region: acpP; PRK00982 441771006761 putative phosphate acyltransferase; Provisional; Region: PRK05331 441771006762 50S ribosomal protein L32; Reviewed; Region: rpmF; PRK12286 441771006763 Uncharacterized ACR, COG1399; Region: DUF177; cl00616 441771006764 acetate kinase A/propionate kinase 2; Reviewed; Region: PRK00180 441771006765 phosphotransacetylase; Reviewed; Region: eutD; PRK09653 441771006766 Sulfite exporter TauE/SafE; Region: TauE; pfam01925 441771006767 Glycine/sarcosine/betaine reductase component B subunits; Region: Gly_reductase; pfam09338 441771006768 RnfC Barrel sandwich hybrid domain; Region: RnfC_N; pfam13375 441771006769 Respiratory-chain NADH dehydrogenase 51 Kd subunit; Region: Complex1_51K; pfam01512 441771006770 Sulfite exporter TauE/SafE; Region: TauE; pfam01925 441771006771 Cache domain; Region: Cache_1; pfam02743 441771006772 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 441771006773 dimerization interface [polypeptide binding]; other site 441771006774 Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer); Region: MA; smart00283 441771006775 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cl19050 441771006776 dimer interface [polypeptide binding]; other site 441771006777 putative CheW interface [polypeptide binding]; other site 441771006778 Saccharopine dehydrogenase N-terminal domain; Region: SDH_N_domain; cl19054 441771006779 Saccharopine dehydrogenase N-terminal domain; Region: SDH_N_domain; cl19054 441771006780 putative glutamate/gamma-aminobutyrate antiporter; Region: put_Glu_GABA_T; TIGR03813 441771006781 Transmembrane amino acid transporter protein; Region: Aa_trans; cl17468 441771006782 Sulfite exporter TauE/SafE; Region: TauE; pfam01925 441771006783 proline racemase; Provisional; Region: PRK13969 441771006784 hydroxyproline-2-epimerase; Provisional; Region: PRK13971; cl19687 441771006785 Glycine/sarcosine/betaine reductase component B subunits; Region: Gly_reductase; pfam09338 441771006786 Glycine/sarcosine/betaine reductase component B subunits; Region: Gly_reductase; pfam09338 441771006787 Domains similar to fish antifreeze type III protein; Region: SAF; cl00555 441771006788 Glycine/sarcosine/betaine reductase component B subunits; Region: Gly_reductase; pfam09338 441771006789 RnfC Barrel sandwich hybrid domain; Region: RnfC_N; pfam13375 441771006790 Respiratory-chain NADH dehydrogenase 51 Kd subunit; Region: Complex1_51K; pfam01512 441771006791 RnfC Barrel sandwich hybrid domain; Region: RnfC_N; pfam13375 441771006792 Respiratory-chain NADH dehydrogenase 51 Kd subunit; Region: Complex1_51K; pfam01512 441771006793 Predicted permease; Region: DUF318; cl17795 441771006794 RnfC Barrel sandwich hybrid domain; Region: RnfC_N; pfam13375 441771006795 Respiratory-chain NADH dehydrogenase 51 Kd subunit; Region: Complex1_51K; pfam01512 441771006796 FOG: CBS domain [General function prediction only]; Region: COG0517 441771006797 The CBS domain, named after human CBS, is a small domain originally identified in cystathionine beta-synthase and is subsequently found in a wide range of different proteins. CBS domains usually occur in tandem repeats. They associate to form a so-called...; Region: CBS_pair; cl15354 441771006798 Transcriptional regulator containing PAS, AAA-type ATPase, and DNA-binding domains [Transcription / Signal transduction mechanisms]; Region: RocR; COG3829 441771006799 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 441771006800 putative active site [active] 441771006801 heme pocket [chemical binding]; other site 441771006802 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 441771006803 Walker A motif; other site 441771006804 ATP binding site [chemical binding]; other site 441771006805 Walker B motif; other site 441771006806 arginine finger; other site 441771006807 Bacterial regulatory protein, Fis family; Region: HTH_8; pfam02954 441771006808 hypothetical protein; Provisional; Region: PRK13670 441771006809 HIGH Nucleotidyl Transferase; Region: HIGH_NTase1; cl17673 441771006810 sporulation integral membrane protein YlbJ; Region: spore_ylbJ; TIGR02871 441771006811 Nucleoside recognition; Region: Gate; pfam07670 441771006812 Phosphopantetheine adenylyltransferase; Region: PPAT; cd02163 441771006813 active site 441771006814 (T/H)XGH motif; other site 441771006815 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 441771006816 S-adenosylmethionine binding site [chemical binding]; other site 441771006817 ATP-dependent DNA helicase RecG; Provisional; Region: PRK10917 441771006818 RecG_wedge_OBF: A subfamily of OB folds corresponding to the OB fold found in the N-terminal (wedge) domain of Escherichia coli RecG. RecG is a branched-DNA-specific helicase, which catalyzes the interconversion of a DNA replication fork to a...; Region: RecG_wedge_OBF; cd04488 441771006819 ssDNA binding site; other site 441771006820 generic binding surface II; other site 441771006821 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 441771006822 ATP binding site [chemical binding]; other site 441771006823 putative Mg++ binding site [ion binding]; other site 441771006824 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 441771006825 nucleotide binding region [chemical binding]; other site 441771006826 ATP-binding site [chemical binding]; other site 441771006827 DAK2 domain fusion protein YloV; Region: YloV; TIGR03599 441771006828 DAK2 domain; Region: Dak2; pfam02734 441771006829 Dihydroxyacetone kinase family; Region: Dak1_2; pfam13684 441771006830 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG1302 441771006831 50S ribosomal protein L28; Reviewed; Region: rpmB; PRK00359 441771006832 Thiamine pyrophosphokinase; Region: TPK; cd07995 441771006833 active site 441771006834 thiamine pyrophosphokinase; Region: thi_PPkinase; TIGR01378 441771006835 dimerization interface [polypeptide binding]; other site 441771006836 thiamine binding site [chemical binding]; other site 441771006837 Ribulose-5-phosphate 3-epimerase (RPE). This enzyme catalyses the interconversion of D-ribulose 5-phosphate (Ru5P) into D-xylulose 5-phosphate, as part of the Calvin cycle (reductive pentose phosphate pathway) in chloroplasts and in the oxidative pentose...; Region: RPE; cd00429 441771006838 substrate binding site [chemical binding]; other site 441771006839 hexamer interface [polypeptide binding]; other site 441771006840 metal binding site [ion binding]; metal-binding site 441771006841 GTPase RsgA; Reviewed; Region: PRK00098 441771006842 S1_YloQ_GTPase: YloQ GTase family (also known as YjeQ and CpgA), S1-like RNA-binding domain. Proteins in the YloQ GTase family bind the ribosome and have GTPase activity. The precise role of this family is unknown. The protein structure is composed of...; Region: S1_YloQ_GTPase; cd04466 441771006843 RNA binding site [nucleotide binding]; other site 441771006844 homodimer interface [polypeptide binding]; other site 441771006845 Ribosomal interacting GTPase YjeQ/EngC, a circularly permuted subfamily of the Ras GTPases; Region: YjeQ_EngC; cd01854 441771006846 GTPase/Zn-binding domain interface [polypeptide binding]; other site 441771006847 GTP/Mg2+ binding site [chemical binding]; other site 441771006848 G4 box; other site 441771006849 G5 box; other site 441771006850 G1 box; other site 441771006851 Switch I region; other site 441771006852 G2 box; other site 441771006853 G3 box; other site 441771006854 Switch II region; other site 441771006855 Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220 441771006856 Catalytic domain of Protein Kinases; Region: PKc; cd00180 441771006857 active site 441771006858 ATP binding site [chemical binding]; other site 441771006859 substrate binding site [chemical binding]; other site 441771006860 activation loop (A-loop); other site 441771006861 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2815 441771006862 PASTA domain of bacterial serine/threonine kinase pknB-like proteins. PknB is a member of a group of related transmembrane sensor kinases present in many gram positive bacteria, which has been shown to regulate cell shape in Mycobacterium tubercolosis; Region: PASTA_pknB; cd06577 441771006863 PASTA domain of bacterial serine/threonine kinase pknB-like proteins. PknB is a member of a group of related transmembrane sensor kinases present in many gram positive bacteria, which has been shown to regulate cell shape in Mycobacterium tubercolosis; Region: PASTA_pknB; cd06577 441771006864 PASTA domain of bacterial serine/threonine kinase pknB-like proteins. PknB is a member of a group of related transmembrane sensor kinases present in many gram positive bacteria, which has been shown to regulate cell shape in Mycobacterium tubercolosis; Region: PASTA_pknB; cd06577 441771006865 Serine/threonine phosphatases, family 2C, catalytic domain; The protein architecture and deduced catalytic mechanism of PP2C phosphatases are similar to the PP1, PP2A, PP2B family of protein Ser/Thr phosphatases, with which PP2C shares no sequence...; Region: PP2Cc; cd00143 441771006866 active site 441771006867 ribosomal RNA large subunit methyltransferase N; Provisional; Region: PRK14454 441771006868 Predicted Fe-S-cluster redox enzyme [General function prediction only]; Region: COG0820 441771006869 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 441771006870 FeS/SAM binding site; other site 441771006871 16S rRNA methyltransferase B; Provisional; Region: PRK14902 441771006872 NusB family; Region: NusB; pfam01029 441771006873 putative RNA binding site [nucleotide binding]; other site 441771006874 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 441771006875 S-adenosylmethionine binding site [chemical binding]; other site 441771006876 Putative neutral zinc metallopeptidase; Region: Zn_peptidase_2; pfam04298 441771006877 methionyl-tRNA formyltransferase; Reviewed; Region: fmt; PRK00005 441771006878 Methionyl-tRNA formyltransferase, N-terminal hydrolase domain; Region: FMT_core_Met-tRNA-FMT_N; cd08646 441771006879 putative active site [active] 441771006880 substrate binding site [chemical binding]; other site 441771006881 putative cosubstrate binding site; other site 441771006882 catalytic site [active] 441771006883 C-terminal domain of Formyltransferase and other enzymes; Region: Met_tRNA_FMT_C; cd08704 441771006884 substrate binding site [chemical binding]; other site 441771006885 Polypeptide or peptide deformylase; a family of metalloenzymes that catalyzes the removal of the N-terminal formyl group in a growing polypeptide chain following translation initiation during protein synthesis in prokaryotes. These enzymes utilize Fe(II)...; Region: Pep_deformylase; cd00487 441771006886 active site 441771006887 catalytic residues [active] 441771006888 metal binding site [ion binding]; metal-binding site 441771006889 primosome assembly protein PriA; Validated; Region: PRK05580 441771006890 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 441771006891 ATP binding site [chemical binding]; other site 441771006892 putative Mg++ binding site [ion binding]; other site 441771006893 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 441771006894 nucleotide binding region [chemical binding]; other site 441771006895 ATP-binding site [chemical binding]; other site 441771006896 bifunctional phosphopantothenoylcysteine decarboxylase/phosphopantothenate synthase; Validated; Region: PRK05579 441771006897 Flavoprotein; Region: Flavoprotein; cl19190 441771006898 DNA / pantothenate metabolizm flavoprotein; Region: DFP; pfam04127 441771006899 DNA-directed RNA polymerase subunit omega; Reviewed; Region: rpoZ; PRK00392 441771006900 Guanylate kinase; Region: Guanylate_kin; pfam00625 441771006901 Guanosine monophosphate kinase (GMPK, EC 2.7.4.8), also known as guanylate kinase (GKase), catalyzes the reversible phosphoryl transfer from adenosine triphosphate (ATP) to guanosine monophosphate (GMP) to yield adenosine diphosphate (ADP) and guanosine...; Region: GMPK; cd00071 441771006902 catalytic site [active] 441771006903 G-X2-G-X-G-K; other site 441771006904 hypothetical protein; Provisional; Region: PRK04323 441771006905 hypothetical protein; Provisional; Region: PRK11820 441771006906 YicC-like family, N-terminal region; Region: YicC_N; pfam03755 441771006907 Domain of unknown function (DUF1732); Region: DUF1732; pfam08340 441771006908 cytoplasmic asparaginase I; Provisional; Region: ansA; PRK09461 441771006909 Type II (periplasmic) bacterial L-asparaginase; Region: L-asparaginase_II; cd08964 441771006910 active site 441771006911 homotetramer interface [polypeptide binding]; other site 441771006912 homodimer interface [polypeptide binding]; other site 441771006913 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 441771006914 sequence-specific DNA binding site [nucleotide binding]; other site 441771006915 salt bridge; other site 441771006916 Stage IV sporulation protein A (spore_IV_A); Region: Spore_IV_A; pfam09547 441771006917 NAD(P)H-dependent glycerol-3-phosphate dehydrogenase; Validated; Region: gpsA; PRK00094 441771006918 NAD-dependent glycerol-3-phosphate dehydrogenase N-terminus; Region: NAD_Gly3P_dh_N; pfam01210 441771006919 NAD-dependent glycerol-3-phosphate dehydrogenase C-terminus; Region: NAD_Gly3P_dh_C; pfam07479 441771006920 GTP-binding protein Der; Reviewed; Region: PRK00093 441771006921 EngA1 GTPase contains the first domain of EngA; Region: EngA1; cd01894 441771006922 G1 box; other site 441771006923 GTP/Mg2+ binding site [chemical binding]; other site 441771006924 Switch I region; other site 441771006925 G2 box; other site 441771006926 Switch II region; other site 441771006927 G3 box; other site 441771006928 G4 box; other site 441771006929 G5 box; other site 441771006930 EngA2 GTPase contains the second domain of EngA; Region: EngA2; cd01895 441771006931 G1 box; other site 441771006932 GTP/Mg2+ binding site [chemical binding]; other site 441771006933 Switch I region; other site 441771006934 G2 box; other site 441771006935 G3 box; other site 441771006936 Switch II region; other site 441771006937 G4 box; other site 441771006938 G5 box; other site 441771006939 KH-domain-like of EngA bacterial GTPase enzymes, C-terminal; Region: KH_dom-like; pfam14714 441771006940 putative FeS-containing Cyanobacterial-specific oxidoreductase; Region: cyano_FeS_chp; TIGR03279 441771006941 PDZ domain, also called DHR (Dlg homologous region) or GLGF (after a conserved sequence motif). Many PDZ domains bind C-terminal polypeptides, though binding to internal (non-C-terminal) polypeptides and even to lipids has been demonstrated; Region: PDZ; cl00117 441771006942 Protein of unknown function (DUF512); Region: DUF512; pfam04459 441771006943 phosphate transport system regulatory protein PhoU; Region: phoU_full; TIGR02135 441771006944 PhoU domain; Region: PhoU; pfam01895 441771006945 PhoU domain; Region: PhoU; pfam01895 441771006946 phosphate transporter ATP-binding protein; Provisional; Region: PRK14240 441771006947 ATP-binding cassette domain of the phosphate transport system; Region: ABC_PstB_phosphate_transporter; cd03260 441771006948 Walker A/P-loop; other site 441771006949 ATP binding site [chemical binding]; other site 441771006950 Q-loop/lid; other site 441771006951 ABC transporter signature motif; other site 441771006952 Walker B; other site 441771006953 D-loop; other site 441771006954 H-loop/switch region; other site 441771006955 ABC-type phosphate transport system, permease component [Inorganic ion transport and metabolism]; Region: PstA; COG0581 441771006956 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 441771006957 dimer interface [polypeptide binding]; other site 441771006958 conserved gate region; other site 441771006959 putative PBP binding loops; other site 441771006960 ABC-ATPase subunit interface; other site 441771006961 ABC-type phosphate transport system, permease component [Inorganic ion transport and metabolism]; Region: PstC; COG0573 441771006962 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 441771006963 dimer interface [polypeptide binding]; other site 441771006964 conserved gate region; other site 441771006965 putative PBP binding loops; other site 441771006966 ABC-ATPase subunit interface; other site 441771006967 ABC transporter, phosphonate, periplasmic substrate-binding protein; Region: Phosphonate-bd; cl19131 441771006968 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 441771006969 dimerization interface [polypeptide binding]; other site 441771006970 phosphate regulon sensor kinase PhoR; Region: phoR_proteo; TIGR02966 441771006971 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 441771006972 putative active site [active] 441771006973 heme pocket [chemical binding]; other site 441771006974 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 441771006975 dimer interface [polypeptide binding]; other site 441771006976 phosphorylation site [posttranslational modification] 441771006977 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 441771006978 ATP binding site [chemical binding]; other site 441771006979 Mg2+ binding site [ion binding]; other site 441771006980 G-X-G motif; other site 441771006981 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 441771006982 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 441771006983 active site 441771006984 phosphorylation site [posttranslational modification] 441771006985 intermolecular recognition site; other site 441771006986 dimerization interface [polypeptide binding]; other site 441771006987 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 441771006988 DNA binding site [nucleotide binding] 441771006989 Multi-copper polyphenol oxidoreductase laccase; Region: Cu-oxidase_4; pfam02578 441771006990 transcriptional regulator NrdR; Validated; Region: nrdR; PRK00464 441771006991 ATP cone domain; Region: ATP-cone; pfam03477 441771006992 Protein implicated in RNA metabolism, contains PRC-barrel domain [General function prediction only]; Region: COG1873; cl17889 441771006993 sporulation sigma factor SigG; Reviewed; Region: PRK08215 441771006994 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 441771006995 Sigma-70 region 3; Region: Sigma70_r3; pfam04539 441771006996 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 441771006997 DNA binding residues [nucleotide binding] 441771006998 sporulation sigma factor SigE; Reviewed; Region: PRK08301 441771006999 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 441771007000 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 441771007001 DNA binding residues [nucleotide binding] 441771007002 Sporulation factor SpoIIGA; Region: Peptidase_U4; pfam03419 441771007003 cell division protein FtsZ; Validated; Region: PRK09330 441771007004 FtsZ is a GTPase that is similar to the eukaryotic tubulins and is essential for cell division in prokaryotes. FtsZ is capable of polymerizing in a GTP-driven process into structures similar to those formed by tubulin. FtsZ forms a ring-shaped septum at...; Region: FtsZ_type1; cd02201 441771007005 nucleotide binding site [chemical binding]; other site 441771007006 SulA interaction site; other site 441771007007 Cell division ATPase FtsA [Cell division and chromosome partitioning]; Region: ftsA; COG0849 441771007008 Cell division protein FtsA; Region: FtsA; smart00842 441771007009 Cell division protein FtsA; Region: FtsA; pfam14450 441771007010 Glycosyltransferase like family 2; Region: Glyco_tranf_2_3; pfam13641 441771007011 EpsO protein participates in the methanolan synthesis; Region: EpsO_like; cd06438 441771007012 DXD motif; other site 441771007013 Tfp pilus assembly protein, ATPase PilU [Cell motility and secretion / Intracellular trafficking and secretion]; Region: PilU; COG5008 441771007014 Pilus retraction ATPase PilT. PilT is a nucleotide binding protein responsible for the retraction of type IV pili, likely by pili disassembly. This retraction provides the force required for travel of bacteria in low water environments by a mechanism...; Region: PilT; cd01131 441771007015 Walker A motif; other site 441771007016 ATP binding site [chemical binding]; other site 441771007017 Walker B motif; other site 441771007018 shikimate 5-dehydrogenase; Reviewed; Region: aroE; PRK00258 441771007019 Shikimate dehydrogenase substrate binding domain; Region: Shikimate_dh_N; pfam08501 441771007020 NAD(P) binding domain of Shikimate dehydrogenase; Region: NAD_bind_Shikimate_DH; cd01065 441771007021 shikimate binding site; other site 441771007022 NAD(P) binding site [chemical binding]; other site 441771007023 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 441771007024 DNA binding residues [nucleotide binding] 441771007025 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 441771007026 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 441771007027 non-specific DNA binding site [nucleotide binding]; other site 441771007028 salt bridge; other site 441771007029 sequence-specific DNA binding site [nucleotide binding]; other site 441771007030 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 441771007031 non-specific DNA binding site [nucleotide binding]; other site 441771007032 salt bridge; other site 441771007033 sequence-specific DNA binding site [nucleotide binding]; other site 441771007034 murein transglycosylase C; Provisional; Region: mltC; PRK11671 441771007035 Plasmid recombination enzyme; Region: Mob_Pre; pfam01076 441771007036 RecA-like NTPases. This family includes the NTP binding domain of F1 and V1 H+ATPases, DnaB and related helicases as well as bacterial RecA and related eukaryotic and archaeal recombinases. This group also includes bacterial conjugation proteins and...; Region: RecA-like_NTPases; cl17233 441771007037 AAA-like domain; Region: AAA_10; pfam12846 441771007038 Walker A motif; other site 441771007039 ATP binding site [chemical binding]; other site 441771007040 Walker B motif; other site 441771007041 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 441771007042 non-specific DNA binding site [nucleotide binding]; other site 441771007043 salt bridge; other site 441771007044 sequence-specific DNA binding site [nucleotide binding]; other site 441771007045 Peptidoglycan recognition proteins (PGRPs) are pattern recognition receptors that bind, and in certain cases, hydrolyze peptidoglycans (PGNs) of bacterial cell walls. PGRPs have been divided into three classes: short PGRPs (PGRP-S), that are small (20...; Region: PGRP; cd06583 441771007046 amidase catalytic site [active] 441771007047 Zn binding residues [ion binding]; other site 441771007048 substrate binding site [chemical binding]; other site 441771007049 Haemolysin XhlA; Region: XhlA; pfam10779 441771007050 lysyl-tRNA synthetase; Reviewed; Region: lysK; PRK00750 441771007051 Domain of unknown function (DUF2382); Region: DUF2382; pfam09557 441771007052 conserved domain; Region: TIGR02271 441771007053 PDDEXK-like domain of unknown function (DUF3799); Region: DUF3799; pfam12684 441771007054 RecT family; Region: RecT; pfam03837 441771007055 DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213 441771007056 Cell division protein FtsI/penicillin-binding protein 2 [Cell envelope biogenesis, outer membrane]; Region: FtsI; COG0768 441771007057 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; pfam00905 441771007058 Uridine monophosphate kinase (UMPK, EC 2.7.1.48), also known as uridine kinase or uridine-cytidine kinase (UCK), catalyzes the reversible phosphoryl transfer from ATP to uridine or cytidine to yield UMP or CMP. In the primidine nucleotide-salvage pathway; Region: UMPK; cd02023 441771007059 ATP-binding site [chemical binding]; other site 441771007060 Sugar specificity; other site 441771007061 Pyrimidine base specificity; other site 441771007062 Collagenase and related proteases [Posttranslational modification, protein turnover, chaperones]; Region: COG0826 441771007063 putative protease; Provisional; Region: PRK15452 441771007064 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 441771007065 S-adenosylmethionine binding site [chemical binding]; other site 441771007066 proteins similar to Escherichia coli yceG; Region: yceG_like; cd08010 441771007067 dimerization interface [polypeptide binding]; other site 441771007068 Predicted membrane GTPase involved in stress response [Signal transduction mechanisms]; Region: TypA; COG1217 441771007069 Tyrosine phosphorylated protein A (TypA)/BipA family belongs to ribosome-binding GTPases; Region: TypA_BipA; cd01891 441771007070 G1 box; other site 441771007071 putative GEF interaction site [polypeptide binding]; other site 441771007072 GTP/Mg2+ binding site [chemical binding]; other site 441771007073 Switch I region; other site 441771007074 G2 box; other site 441771007075 G3 box; other site 441771007076 Switch II region; other site 441771007077 G4 box; other site 441771007078 G5 box; other site 441771007079 BipA_TypA_II: domain II of BipA (also called TypA) having homology to domain II of the elongation factors (EFs) EF-G and EF-Tu. BipA is a highly conserved protein with global regulatory properties in Escherichia coli. BipA is phosphorylated on a...; Region: BipA_TypA_II; cd03691 441771007080 BipA_TypA_C: a C-terminal portion of BipA or TypA having homology to the C terminal domains of the elongation factors EF-G and EF-2. A member of the ribosome binding GTPase superfamily, BipA is widely distributed in bacteria and plants. BipA is a highly...; Region: BipA_TypA_C; cd03710 441771007081 mRNA degradation ribonucleases J1/J2 (metallo-beta-lactamase superfamily) [Translation, ribosomal structure and biogenesis; Replication, recombination and repair]; Region: COG0595 441771007082 Metallo-beta-lactamase superfamily; Region: Lactamase_B; smart00849 441771007083 RNA-metabolizing metallo-beta-lactamase; Region: RMMBL; pfam07521 441771007084 Ferric uptake regulator(Fur) and related metalloregulatory proteins; typically iron-dependent, DNA-binding repressors and activators; Region: Fur_like; cd07153 441771007085 metal binding site 2 [ion binding]; metal-binding site 441771007086 putative DNA binding helix; other site 441771007087 metal binding site 1 [ion binding]; metal-binding site 441771007088 dimer interface [polypeptide binding]; other site 441771007089 structural Zn2+ binding site [ion binding]; other site 441771007090 Protein of unknown function (DUF1292); Region: DUF1292; pfam06949 441771007091 Holliday junction resolvase-like protein; Reviewed; Region: PRK00109 441771007092 hypothetical protein; Provisional; Region: PRK05473 441771007093 alanyl-tRNA synthetase; Reviewed; Region: alaS; PRK00252 441771007094 Alanyl-tRNA synthetase (AlaRS) class II core catalytic domain. AlaRS is a homodimer. It is responsible for the attachment of alanine to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for ATP-dependent...; Region: AlaRS_core; cd00673 441771007095 motif 1; other site 441771007096 active site 441771007097 motif 2; other site 441771007098 motif 3; other site 441771007099 Threonyl and Alanyl tRNA synthetase second additional domain; Region: tRNA_SAD; smart00863 441771007100 DHHA1 domain; Region: DHHA1; pfam02272 441771007101 Predicted permease, member of the PurR regulon [General function prediction only]; Region: yhhT; COG0628 441771007102 PRC-barrel domain containing protein [General function prediction only]; Region: COG3881 441771007103 PRC-barrel domain; Region: PRC; pfam05239 441771007104 Iron-sulfur cluster scaffold-like proteins; Region: IscU_like; cd06664 441771007105 trimerization site [polypeptide binding]; other site 441771007106 active site 441771007107 cysteine desulfurase NifS; Region: FeS_nifS; TIGR03402 441771007108 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 441771007109 catalytic residue [active] 441771007110 Predicted transcriptional regulator [Transcription]; Region: COG1959 441771007111 Rrf2 family protein; Region: rrf2_super; TIGR00738 441771007112 recombination factor protein RarA; Reviewed; Region: PRK13342 441771007113 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 441771007114 Walker A motif; other site 441771007115 ATP binding site [chemical binding]; other site 441771007116 Walker B motif; other site 441771007117 arginine finger; other site 441771007118 MgsA AAA+ ATPase C terminal; Region: MgsA_C; pfam12002 441771007119 histidinol-phosphatase; Provisional; Region: PRK05588 441771007120 Polymerase and Histidinol Phosphatase domain; Region: PHP; cl17102 441771007121 active site 441771007122 Predicted permeases [General function prediction only]; Region: COG0679 441771007123 EDD domain protein, DegV family; Region: DegV; TIGR00762 441771007124 SirA_like_N, a protein of unknown function with an N-terminal SirA-like domain. The SirA, YedF, YeeD protein family is present in bacteria as well as archaea. SirA (also known as UvrY, and YhhP) belongs to a family of a two-component response...; Region: SirA_like_N; cd03421 441771007125 selenium metabolism protein YedF; Region: selenium_YedF; TIGR03527 441771007126 CPxP motif; other site 441771007127 DsrE/DsrF-like family; Region: DrsE; pfam02635 441771007128 ornithine cyclodeaminase; Validated; Region: PRK08618 441771007129 Shikimate / quinate 5-dehydrogenase; Region: Shikimate_DH; cl19124 441771007130 Na+/alanine symporter [Amino acid transport and metabolism]; Region: AlsT; COG1115 441771007131 Domain of unknown function (DUF4397); Region: DUF4397; pfam14344 441771007132 Domain of unknown function (DUF4397); Region: DUF4397; pfam14344 441771007133 Copper amine oxidase N-terminal domain; Region: Cu_amine_oxidN1; pfam07833 441771007134 phosphoribosylformylglycinamidine synthase, clade II; Region: FGAM-synthase; TIGR01857 441771007135 PurL subunit of the formylglycinamide ribonucleotide amidotransferase (FGAR-AT), first repeat. FGAR-AT catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to formylglycinamidine ribonucleotide (FGAM), ADP; Region: PurL_repeat1; cd02203 441771007136 dimerization interface [polypeptide binding]; other site 441771007137 ATP binding site [chemical binding]; other site 441771007138 PurL subunit of the formylglycinamide ribonucleotide amidotransferase (FGAR-AT), second repeat. FGAR-AT catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to formylglycinamidine ribonucleotide (FGAM), ADP; Region: PurL_repeat2; cd02204 441771007139 dimerization interface [polypeptide binding]; other site 441771007140 ATP binding site [chemical binding]; other site 441771007141 Type 1 glutamine amidotransferase (GATase1)-like domain found in Formylglycinamide ribonucleotide amidotransferase; Region: GATase1_FGAR_AT; cd01740 441771007142 putative active site [active] 441771007143 catalytic triad [active] 441771007144 Na+-driven multidrug efflux pump [Defense mechanisms]; Region: NorM; COG0534 441771007145 Subfamily of the multidrug and toxic compound extrusion (MATE)-like proteins similar to Streptococcus aureus MepA; Region: MATE_MepA_like; cd13143 441771007146 phosphoenolpyruvate synthase; Validated; Region: PRK06241 441771007147 Pyruvate phosphate dikinase, PEP/pyruvate binding domain; Region: PPDK_N; pfam01326 441771007148 PEP-utilizing enzyme, mobile domain; Region: PEP-utilizers; pfam00391 441771007149 Phosphopantetheine attachment site; Region: PP-binding; pfam00550 441771007150 AMP-binding enzyme; Region: AMP-binding; pfam00501 441771007151 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 441771007152 active site 441771007153 AMP binding site [chemical binding]; other site 441771007154 acyl-activating enzyme (AAE) consensus motif; other site 441771007155 CoA binding site [chemical binding]; other site 441771007156 3-oxoacyl-[acyl-carrier-protein]; Region: FabH; COG0332 441771007157 Ketoacyl-acyl carrier protein synthase III (KASIII) initiates the elongation in type II fatty acid synthase systems. It is found in bacteria and plants. Elongation of fatty acids in the type II systems occurs by Claisen condensation of malonyl-acyl...; Region: KAS_III; cd00830 441771007158 dimer interface [polypeptide binding]; other site 441771007159 active site 441771007160 CoA binding pocket [chemical binding]; other site 441771007161 Putative lysophospholipase; Region: Hydrolase_4; cl19140 441771007162 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 441771007163 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 441771007164 amino acid adenylation domain; Region: AA-adenyl-dom; TIGR01733 441771007165 acyl-activating enzyme (AAE) consensus motif; other site 441771007166 AMP binding site [chemical binding]; other site 441771007167 active site 441771007168 CoA binding site [chemical binding]; other site 441771007169 Phosphopantetheine attachment site; Region: PP-binding; pfam00550 441771007170 Acetyltransferases [General function prediction only]; Region: RimI; COG0456 441771007171 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 441771007172 Coenzyme A binding pocket [chemical binding]; other site 441771007173 Phosphopantetheine attachment site; Region: PP-binding; cl09936 441771007174 Adenine nucleotide alpha hydrolases superfamily including N type ATP PPases, ATP sulphurylases Universal Stress Response protein and electron transfer flavoprotein (ETF). The domain forms a apha/beta/apha fold which binds to Adenosine nucleotide; Region: AANH_like; cl00292 441771007175 Ligand Binding Site [chemical binding]; other site 441771007176 hypothetical protein; Validated; Region: PRK07080 441771007177 Phosphopantetheinyl transferase [Coenzyme metabolism]; Region: Sfp; COG2091 441771007178 4'-phosphopantetheinyl transferase superfamily; Region: ACPS; pfam01648 441771007179 ornithine carbamoyltransferase; Provisional; Region: PRK04284 441771007180 Aspartate/ornithine carbamoyltransferase, carbamoyl-P binding domain; Region: OTCace_N; pfam02729 441771007181 Aspartate/ornithine carbamoyltransferase, Asp/Orn binding domain; Region: OTCace; pfam00185 441771007182 AAK_CK: Carbamate kinase (CK) catalyzes both the ATP-phosphorylation of carbamate and carbamoyl phosphate (CP) utilization with the production of ATP from ADP and CP. Both CK (this CD) and nonhomologous CP synthetase synthesize carbamoyl phosphate, an...; Region: AAK_CK; cd04235 441771007183 putative substrate binding site [chemical binding]; other site 441771007184 nucleotide binding site [chemical binding]; other site 441771007185 nucleotide binding site [chemical binding]; other site 441771007186 homodimer interface [polypeptide binding]; other site 441771007187 Serine-glycine hydroxymethyltransferase (SHMT). This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). SHMT carries out interconversion of serine and glycine; it catalyzes the transfer of hydroxymethyl...; Region: SHMT; cd00378 441771007188 dimer interface [polypeptide binding]; other site 441771007189 active site 441771007190 glycine-pyridoxal phosphate binding site [chemical binding]; other site 441771007191 folate binding site [chemical binding]; other site 441771007192 Beta-eliminating lyase; Region: Beta_elim_lyase; pfam01212 441771007193 Uncharacterized conserved protein [Function unknown]; Region: COG2966 441771007194 Protein of unknown function (DUF1212); Region: DUF1212; pfam06738 441771007195 Protein of unknown function (DUF3815); Region: DUF3815; pfam12821 441771007196 Transcriptional regulators CsoR (copper-sensitive operon repressor), RcnR, and FrmR, and related domains; this domain superfamily was previously known as DUF156; Region: CsoR-like_DUF156; cd10148 441771007197 putative homodimer interface [polypeptide binding]; other site 441771007198 putative homotetramer interface [polypeptide binding]; other site 441771007199 putative allosteric switch controlling residues; other site 441771007200 putative metal binding site [ion binding]; other site 441771007201 putative homodimer-homodimer interface [polypeptide binding]; other site 441771007202 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 441771007203 haloacid dehalogenase-like hydrolase; Region: Hydrolase_3; pfam08282 441771007204 active site 441771007205 motif I; other site 441771007206 motif II; other site 441771007207 haloacid dehalogenase-like hydrolase; Region: HAD; cl19137 441771007208 Entericidin EcnA/B family; Region: Entericidin; cl02322 441771007209 nucleotidyl transferase superfamily; Region: nt_trans; cl00015 441771007210 active site 441771007211 nucleotide binding site [chemical binding]; other site 441771007212 HIGH motif; other site 441771007213 KMSKS motif; other site 441771007214 NAD-dependent, lactate dehydrogenase-like, 2-hydroxycarboxylate dehydrogenase family; Region: LDH_MDH_like; cl17195 441771007215 NAD(P) binding site [chemical binding]; other site 441771007216 LDH/MDH dimer interface [polypeptide binding]; other site 441771007217 substrate binding site [chemical binding]; other site 441771007218 Multimeric flavodoxin WrbA [General function prediction only]; Region: WrbA; COG0655 441771007219 Predicted metal-dependent phosphoesterases (PHP family) [General function prediction only]; Region: COG0613 441771007220 Polymerase and Histidinol Phosphatase domain; Region: PHP; cl17102 441771007221 active site 441771007222 M18 Peptidase Aminopeptidase I; Region: M18_API; cd05659 441771007223 oligomer interface [polypeptide binding]; other site 441771007224 putative active site [active] 441771007225 metal binding site [ion binding]; metal-binding site 441771007226 CorA-like Mg2+ transporter protein; Region: CorA; pfam01544 441771007227 Thermotoga maritima CorA-like family; Region: TmCorA-like; cd12822 441771007228 oligomer interface [polypeptide binding]; other site 441771007229 metal binding site [ion binding]; metal-binding site 441771007230 metal binding site [ion binding]; metal-binding site 441771007231 putative Cl binding site [ion binding]; other site 441771007232 aspartate ring; other site 441771007233 basic sphincter; other site 441771007234 hydrophobic gate; other site 441771007235 periplasmic entrance; other site 441771007236 5,10-methenyltetrahydrofolate synthetase; Region: MTHFS_bact; TIGR02727 441771007237 HPr kinase/phosphorylase; Provisional; Region: PRK05428 441771007238 HPr Serine kinase N terminus; Region: Hpr_kinase_N; pfam02603 441771007239 HprK/P, the bifunctional histidine-containing protein kinase/phosphatase, controls the phosphorylation state of the phosphocarrier protein HPr and regulates the utilization of carbon sources by gram-positive bacteria. It catalyzes both the ATP-dependent...; Region: HprK_C; cd01918 441771007240 Hpr binding site; other site 441771007241 active site 441771007242 homohexamer subunit interaction site [polypeptide binding]; other site 441771007243 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4224 441771007244 Uncharacterized conserved protein [Function unknown]; Region: COG0398 441771007245 Uncharacterized conserved protein [Function unknown]; Region: COG0398 441771007246 Fe-S oxidoreductase [Energy production and conversion]; Region: GlpC; COG0247 441771007247 4Fe-4S dicluster domain; Region: Fer4_17; pfam13534 441771007248 Cysteine-rich domain; Region: CCG; pfam02754 441771007249 Cysteine-rich domain; Region: CCG; pfam02754 441771007250 Phosphotransferase enzyme family; Region: APH; pfam01636 441771007251 Aminoglycoside 3'-phosphotransferase (APH) and Choline Kinase (ChoK) family. The APH/ChoK family is part of a larger superfamily that includes the catalytic domains of other kinases, such as the typical serine/threonine/tyrosine protein kinases (PKs)...; Region: APH_ChoK_like; cl17270 441771007252 active site 441771007253 ATP binding site [chemical binding]; other site 441771007254 transferase 1, rSAM/selenodomain-associated; Region: glyco_like_cofC; TIGR04282 441771007255 GT_2_like_a represents a glycosyltransferase family-2 subfamily with unknown function; Region: GT_2_like_a; cd02522 441771007256 transferase 2, rSAM/selenodomain-associated; Region: glyco_like_mftF; TIGR04283 441771007257 Probable Catalytic site; other site 441771007258 Rhodanese-related sulfurtransferase [Inorganic ion transport and metabolism]; Region: SseA; COG2897 441771007259 Thiosulfate sulfurtransferase (TST), N-terminal, inactive domain. TST contains 2 copies of the Rhodanese Homology Domain; this is the 1st repeat, which does not contain the catalytically active Cys residue. The role of the 1st repeat is uncertain, but it...; Region: TST_Repeat_1; cd01448 441771007260 active site residue [active] 441771007261 Thiosulfate sulfurtransferase (TST), C-terminal, catalytic domain. TST contains 2 copies of the Rhodanese Homology Domain; this is the second repeat. Only the second repeat contains the catalytically active Cys residue; Region: TST_Repeat_2; cd01449 441771007262 active site residue [active] 441771007263 Bacterial fructose-1,6-bisphosphatase, glpX-encoded. A dimeric enzyme dependent on Mg(2+). glpX-encoded FPBase (FBPase class II) differs from other members of the inositol-phosphatase superfamily by permutation of secondary structure elements. The core...; Region: FBPase_glpX; cd01516 441771007264 putative active site [active] 441771007265 Spo0E like sporulation regulatory protein; Region: SpoOE-like; pfam09388 441771007266 Uncharacterized flavoproteins [Energy production and conversion]; Region: FpaA; COG0426 441771007267 Metallo-beta-lactamase superfamily; Region: Lactamase_B; smart00849 441771007268 NADPH-dependent FMN reductase; Region: FMN_red; cl00438 441771007269 Inosine-uridine preferring nucleoside hydrolase; Region: IU_nuc_hydro; pfam01156 441771007270 active site 441771007271 Polypeptide or peptide deformylase; a family of metalloenzymes that catalyzes the removal of the N-terminal formyl group in a growing polypeptide chain following translation initiation during protein synthesis in prokaryotes. These enzymes utilize Fe(II)...; Region: Pep_deformylase; cd00487 441771007272 active site 441771007273 catalytic residues [active] 441771007274 metal binding site [ion binding]; metal-binding site 441771007275 V-type ATP synthase subunit D; Reviewed; Region: PRK00373 441771007276 V-type ATP synthase subunit B; Provisional; Region: PRK04196 441771007277 ATP synthase alpha/beta family, beta-barrel domain; Region: ATP-synt_ab_N; pfam02874 441771007278 V/A-type ATP synthase (non-catalytic) subunit B. These ATPases couple ATP hydrolysis to the build up of a H+ gradient, but V-type ATPases do not catalyze the reverse reaction. The Vacuolar (V-type) ATPase is found in the membranes of vacuoles, the golgi...; Region: V_A-ATPase_B; cd01135 441771007279 Walker A motif homologous position; other site 441771007280 Walker B motif; other site 441771007281 ATP synthase alpha/beta chain, C terminal domain; Region: ATP-synt_ab_C; pfam00306 441771007282 V-type ATP synthase subunit A; Provisional; Region: PRK04192 441771007283 ATP synthase alpha/beta family, beta-barrel domain; Region: ATP-synt_ab_N; pfam02874 441771007284 V/A-type ATP synthase catalytic subunit A. These ATPases couple ATP hydrolysis to the build up of a H+ gradient, but V-type ATPases do not catalyze the reverse reaction. The Vacuolar (V-type) ATPase is found in the membranes of vacuoles, the golgi...; Region: V_A-ATPase_A; cd01134 441771007285 Walker A motif/ATP binding site; other site 441771007286 Walker B motif; other site 441771007287 ATP synthase alpha/beta chain, C terminal domain; Region: ATP-synt_ab_C; pfam00306 441771007288 V-type ATP synthase subunit F; Provisional; Region: PRK01395 441771007289 V-type ATP synthase subunit C; Provisional; Region: PRK01198 441771007290 Archaeal/vacuolar-type H+-ATPase subunit C [Energy production and conversion]; Region: NtpC; COG1527 441771007291 V-type ATP synthase subunit E; Provisional; Region: PRK03963 441771007292 Apolipophorin-III and similar insect proteins; Region: ApoLp-III_like; cl19113 441771007293 V-type ATP synthase subunit K; Validated; Region: PRK06558 441771007294 ATP synthase subunit C; Region: ATP-synt_C; pfam00137 441771007295 ATP synthase subunit C; Region: ATP-synt_C; pfam00137 441771007296 V-type ATP synthase subunit I; Validated; Region: PRK05771 441771007297 V-type ATP synthase subunit H; Validated; Region: PRK08404 441771007298 Apolipophorin-III and similar insect proteins; Region: ApoLp-III_like; cl19113 441771007299 B12 binding domain_like associated with radical SAM domain. This domain shows similarity with B12 (adenosylcobamide) binding domains found in several enzymes, such as glutamate mutase, methionine synthase and methylmalonyl-CoA mutase, but it lacks the...; Region: radical_SAM_B12_BD; cd02068 441771007300 Radical SAM superfamily; Region: Radical_SAM; pfam04055 441771007301 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 441771007302 FeS/SAM binding site; other site 441771007303 Protein of unknown function (DUF4080); Region: DUF4080; pfam13311 441771007304 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl17173 441771007305 Zinc dependent phospholipase C (alpha toxin); Region: Zn_dep_PLPC; cd11009 441771007306 Zn binding site [ion binding]; other site 441771007307 Cation transporter/ATPase, N-terminus; Region: Cation_ATPase_N; pfam00690 441771007308 Cation transport ATPase [Inorganic ion transport and metabolism]; Region: MgtA; COG0474 441771007309 E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122 441771007310 Putative hydrolase of sodium-potassium ATPase alpha subunit; Region: Hydrolase_like2; pfam13246 441771007311 haloacid dehalogenase-like hydrolase; Region: HAD; pfam12710 441771007312 Soluble P-type ATPase [General function prediction only]; Region: COG4087 441771007313 Cation transporting ATPase, C-terminus; Region: Cation_ATPase_C; pfam00689 441771007314 putative manganese-dependent inorganic pyrophosphatase; Provisional; Region: PRK14869 441771007315 The CBS domain, named after human CBS, is a small domain originally identified in cystathionine beta-synthase and is subsequently found in a wide range of different proteins. CBS domains usually occur in tandem repeats. They associate to form a so-called...; Region: CBS_pair; cl15354 441771007316 DRTGG domain; Region: DRTGG; pfam07085 441771007317 The CBS domain, named after human CBS, is a small domain originally identified in cystathionine beta-synthase and is subsequently found in a wide range of different proteins. CBS domains usually occur in tandem repeats. They associate to form a so-called...; Region: CBS_pair; cl15354 441771007318 DHH family; Region: DHH; pfam01368 441771007319 DHHA2 domain; Region: DHHA2; pfam02833 441771007320 flagellar basal body rod protein FlgG; Reviewed; Region: flgG; PRK12817 441771007321 Flagella basal body rod protein; Region: Flg_bb_rod; pfam00460 441771007322 Flagellar basal body rod FlgEFG protein C-terminal; Region: Flg_bbr_C; pfam06429 441771007323 flagellar basal body rod protein FlgG; Reviewed; Region: flgG; PRK12818 441771007324 Flagella basal body rod protein; Region: Flg_bb_rod; pfam00460 441771007325 Flagellar basal body rod FlgEFG protein C-terminal; Region: Flg_bbr_C; pfam06429 441771007326 RNA polymerase sigma factor, FliA/WhiG family; Region: FliA_WhiG; TIGR02479 441771007327 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 441771007328 Sigma-70 region 3; Region: Sigma70_r3; pfam04539 441771007329 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 441771007330 DNA binding residues [nucleotide binding] 441771007331 Flagellar protein YcgR; Region: YcgR_2; pfam12945 441771007332 PilZ domain; Region: PilZ; pfam07238 441771007333 Antiactivator of flagellar biosynthesis FleN, an ATPase [Cell motility]; Region: flhG; COG0455 441771007334 FleN is a member of the Fer4_NifH superfamily. It shares the common function as an ATPase, with the ATP-binding domain at the N-terminus. In Pseudomonas aeruginosa, FleN gene is involved in regulating the number of flagella and chemotactic motility by...; Region: FleN-like; cd02038 441771007335 The Fer4_NifH superfamily contains a variety of proteins which share a common ATP-binding domain. Functionally, proteins in this superfamily use the energy from hydrolysis of NTP to transfer electron or ion; Region: Fer4_NifH; cl17203 441771007336 P-loop; other site 441771007337 flagellar biosynthesis regulator FlhF; Validated; Region: flhF; PRK05703 441771007338 SRP54-type protein, GTPase domain; Region: SRP54; smart00962 441771007339 flagellar biosynthesis protein FlhA; Validated; Region: flhA; PRK06012 441771007340 bifunctional flagellar biosynthesis protein FliR/FlhB; Provisional; Region: PRK12772 441771007341 Flagellar biosynthesis pathway, component FliR [Cell motility and secretion / Intracellular trafficking and secretion]; Region: FliR; COG1684 441771007342 flagellar biosynthesis protein FlhB; Reviewed; Region: flhB; PRK05702 441771007343 Flagellar biosynthesis pathway, component FliQ [Cell motility and secretion / Intracellular trafficking and secretion]; Region: FliQ; COG1987 441771007344 flagellar biosynthesis protein FliP; Reviewed; Region: fliP; PRK05699 441771007345 flagellar biosynthetic protein FliO; Region: FliO_TIGR; TIGR03500 441771007346 flagellar motor protein MotS; Reviewed; Region: PRK06925 441771007347 Membrane MotB of proton-channel complex MotA/MotB; Region: MotB_plug; pfam13677 441771007348 Peptidoglycan binding domains similar to the C-terminal domain of outer-membrane protein OmpA; Region: OmpA_C-like; cd07185 441771007349 ligand binding site [chemical binding]; other site 441771007350 Flagellar motor component [Cell motility and secretion]; Region: MotA; COG1291 441771007351 Flagellar protein (FlbD); Region: FlbD; pfam06289 441771007352 flagellar basal body rod protein FlgG; Provisional; Region: flgG; PRK12636 441771007353 Flagella basal body rod protein; Region: Flg_bb_rod; pfam00460 441771007354 flagellar basal body rod protein FlgB; Provisional; Region: flgB; cl19173 441771007355 Flagellar basal body rod FlgEFG protein C-terminal; Region: Flg_bbr_C; pfam06429 441771007356 Protein of unknown function (DUF3766); Region: DUF3766; cl11797 441771007357 Flagellar hook capping protein - N-terminal region; Region: FlgD; pfam03963 441771007358 Fungal symportin 1 (syo1) and similar proteins; Region: Syo1_like; cd13394 441771007359 Flagellar hook-length control protein FliK; Region: Flg_hook; pfam02120 441771007360 flagellar export protein FliJ; Region: flagell_FliJ; TIGR02473 441771007361 flagellar protein export ATPase FliI; Region: FliI_clade2; TIGR03497 441771007362 ATP synthase alpha/beta family, beta-barrel domain; Region: ATP-synt_ab_N; pfam02874 441771007363 Flagellum-specific ATPase/type III secretory pathway virulence-related protein. This group of ATPases are responsible for the export of flagellum and virulence-related proteins. The bacterial flagellar motor is similar to the F0F1-ATPase, in that they...; Region: ATPase_flagellum-secretory_path_III; cd01136 441771007364 Walker A motif/ATP binding site; other site 441771007365 Walker B motif; other site 441771007366 type III secretion apparatus protein, HrpE/YscL family; Region: HrpE_YscL_not; TIGR02499 441771007367 Flagellar assembly protein FliH; Region: FliH; cl19405 441771007368 flagellar motor switch protein G; Validated; Region: fliG; PRK05686 441771007369 FliG N-terminal domain; Region: FliG_N; pfam14842 441771007370 FliG middle domain; Region: FliG_M; pfam14841 441771007371 FliG C-terminal domain; Region: FliG_C; pfam01706 441771007372 flagellar MS-ring protein; Reviewed; Region: fliF; PRK06007 441771007373 Secretory protein of YscJ/FliF family; Region: YscJ_FliF; cl01907 441771007374 Flagellar M-ring protein C-terminal; Region: YscJ_FliF_C; pfam08345 441771007375 flagellar hook-basal body protein FliE; Provisional; Region: fliE; PRK12728 441771007376 flagellar basal body rod protein FlgC; Provisional; Region: flgC; PRK12630 441771007377 Flagella basal body rod protein; Region: Flg_bb_rod; pfam00460 441771007378 Flagellar basal body rod FlgEFG protein C-terminal; Region: Flg_bbr_C; pfam06429 441771007379 flagellar basal body rod protein FlgB; Provisional; Region: flgB; PRK12623 441771007380 flagellar basal body rod protein FlgB; Provisional; Region: flgB; cl19173 441771007381 flagellin; Provisional; Region: PRK12804 441771007382 Bacterial flagellin N-terminal helical region; Region: Flagellin_N; pfam00669 441771007383 Bacterial flagellin C-terminal helical region; Region: Flagellin_C; pfam00700 441771007384 argininosuccinate lyase; Provisional; Region: PRK00855 441771007385 Argininosuccinate lyase (argininosuccinase, ASAL); Region: Argininosuccinate_lyase; cd01359 441771007386 active sites [active] 441771007387 tetramer interface [polypeptide binding]; other site 441771007388 Argininosuccinate synthase. The Argininosuccinate synthase is a urea cycle enzyme that catalyzes the penultimate step in arginine biosynthesis: the ATP-dependent ligation of citrulline to aspartate to form argininosuccinate, AMP and pyrophosphate . In...; Region: Argininosuccinate_Synthase; cd01999 441771007389 ANP binding site [chemical binding]; other site 441771007390 Substrate Binding Site II [chemical binding]; other site 441771007391 Substrate Binding Site I [chemical binding]; other site 441771007392 cardiolipin synthetase; Reviewed; Region: cls; PRK01642 441771007393 Phospholipase_D-nuclease N-terminal; Region: PLDc_N; pfam13396 441771007394 Catalytic domain, repeat 1, of bacterial cardiolipin synthase and similar proteins; Region: PLDc_CLS_1; cd09110 441771007395 putative active site [active] 441771007396 catalytic site [active] 441771007397 catalytic domain repeat 2 of bacterial cardiolipin synthase and similar proteins; Region: PLDc_CLS_2; cd09112 441771007398 putative active site [active] 441771007399 catalytic site [active] 441771007400 Predicted membrane protein [Function unknown]; Region: COG4129 441771007401 Bacterial protein of unknown function (DUF939); Region: DUF939; pfam06081 441771007402 Predicted integral membrane protein [Function unknown]; Region: COG5652 441771007403 Membrane protein involved in the export of O-antigen and teichoic acid [General function prediction only]; Region: RfbX; COG2244 441771007404 Multidrug and toxic compound extrusion family and similar proteins; Region: MATE_like; cl09326 441771007405 Nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: WcaG; COG0451 441771007406 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 441771007407 NAD(P) binding site [chemical binding]; other site 441771007408 active site 441771007409 N-acetylneuraminate synthase; Region: NeuB_NnaB; TIGR03569 441771007410 NeuB family; Region: NeuB; pfam03102 441771007411 C-terminal SAF domain of sialic acid synthetase; Region: SAF_NeuB_like; cd11615 441771007412 NeuB binding interface [polypeptide binding]; other site 441771007413 putative substrate binding site [chemical binding]; other site 441771007414 CMP-NeuAc_Synthase activates N-acetylneuraminic acid by adding CMP moiety; Region: CMP-NeuAc_Synthase; cd02513 441771007415 ligand binding site; other site 441771007416 tetramer interface; other site 441771007417 Spore coat polysaccharide biosynthesis protein, predicted glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: spsG; COG3980 441771007418 Glycosyltransferase family 28 C-terminal domain; Region: Glyco_tran_28_C; cl19139 441771007419 Glycosyltransferase family 52; Region: Glyco_transf_52; pfam07922 441771007420 Domain of unknown function (DUF4422); Region: DUF4422; pfam14393 441771007421 UDP-galactopyranose mutase [Cell envelope biogenesis, outer membrane]; Region: Glf; COG0562 441771007422 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450 441771007423 UDP-galactopyranose mutase; Region: GLF; pfam03275 441771007424 Bacterial sugar transferase; Region: Bac_transf; pfam02397 441771007425 capsular exopolysaccharide family; Region: eps_fam; TIGR01007 441771007426 AAA domain; Region: AAA_31; pfam13614 441771007427 Capsular polysaccharide biosynthesis protein [Carbohydrate transport and metabolism / Cell envelope biogenesis, outer membrane]; Region: CapC; COG4464 441771007428 PHP domain; Region: PHP; pfam02811 441771007429 Capsular polysaccharide biosynthesis protein [Cell envelope biogenesis, outer membrane]; Region: COG3944 441771007430 Chain length determinant protein; Region: Wzz; pfam02706 441771007431 G-rich domain on putative tyrosine kinase; Region: GNVR; pfam13807 441771007432 Transcriptional regulator [Transcription]; Region: LytR; COG1316 441771007433 Putative motility protein; Region: YjfB_motility; pfam14070 441771007434 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cl19050 441771007435 dimer interface [polypeptide binding]; other site 441771007436 putative CheW interface [polypeptide binding]; other site 441771007437 flagellin; Provisional; Region: PRK12804 441771007438 Bacterial flagellin N-terminal helical region; Region: Flagellin_N; pfam00669 441771007439 Bacterial flagellin C-terminal helical region; Region: Flagellin_C; pfam00700 441771007440 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 441771007441 binding surface 441771007442 TPR motif; other site 441771007443 SGNH_hydrolase, or GDSL_hydrolase, is a diverse family of lipases and esterases. The tertiary fold of the enzyme is substantially different from that of the alpha/beta hydrolase family and unique among all known hydrolases; its active site closely...; Region: SGNH_hydrolase; cl01053 441771007444 catalytic triad [active] 441771007445 pseudaminic acid biosynthesis-associated protein PseG; Region: PseG; TIGR03590 441771007446 SGNH_hydrolase, or GDSL_hydrolase, is a diverse family of lipases and esterases. The tertiary fold of the enzyme is substantially different from that of the alpha/beta hydrolase family and unique among all known hydrolases; its active site closely...; Region: SGNH_hydrolase; cd00229 441771007447 active site 441771007448 catalytic triad [active] 441771007449 oxyanion hole [active] 441771007450 D-alanyl-lipoteichoic acid biosynthesis protein DltD; Region: LTA_DltD; TIGR04092 441771007451 GDSL-like Lipase/Acylhydrolase family; Region: Lipase_GDSL_2; pfam13472 441771007452 Glycosyltransferases involved in cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WcaA; COG0463 441771007453 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cd00761 441771007454 active site 441771007455 Tetratricopeptide repeat; Region: TPR_12; pfam13424 441771007456 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 441771007457 binding surface 441771007458 TPR motif; other site 441771007459 Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013 441771007460 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 441771007461 Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013 441771007462 glycosyltransferase, GG-Bacteroidales peptide system; Region: glyco_rSAM_CFB; TIGR04157 441771007463 Glutamine amidotransferases class-II (GATase). The glutaminase domain catalyzes an amide nitrogen transfer from glutamine to the appropriate substrate. In this process, glutamine is hydrolyzed to glutamic acid and ammonia. This domain is related to...; Region: Gn_AT_II; cl00319 441771007464 Adenine nucleotide alpha hydrolases superfamily including N type ATP PPases, ATP sulphurylases Universal Stress Response protein and electron transfer flavoprotein (ETF). The domain forms a apha/beta/apha fold which binds to Adenosine nucleotide; Region: AANH_like; cl00292 441771007465 Ligand Binding Site [chemical binding]; other site 441771007466 Left-handed parallel beta-Helix (LbetaH or LbH) domain: The alignment contains 5 turns, each containing three imperfect tandem repeats of a hexapeptide repeat motif (X-[STAV]-X-[LIV]-[GAED]-X). Proteins containing hexapeptide repeats are often enzymes...; Region: LbetaH; cl00160 441771007467 Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013 441771007468 Putative catalytic domain of uncharacterized bacterial proteins from the carbohydrate esterase 4 superfamily; Region: CE4_u7; cd10931 441771007469 putative active site [active] 441771007470 putative catalytic site [active] 441771007471 Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013 441771007472 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 441771007473 Radical SAM superfamily; Region: Radical_SAM; pfam04055 441771007474 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 441771007475 FeS/SAM binding site; other site 441771007476 Cephalosporin hydroxylase; Region: CmcI; pfam04989 441771007477 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 441771007478 S-adenosylmethionine binding site [chemical binding]; other site 441771007479 C-methyltransferase C-terminal domain; Region: Methyltransf_14; pfam08484 441771007480 Nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: WcaG; COG0451 441771007481 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 441771007482 NAD(P) binding site [chemical binding]; other site 441771007483 active site 441771007484 dTDP-4-dehydrorhamnose 3,5-epimerase; Region: dTDP_sugar_isom; cl17405 441771007485 Putative zinc binding domain; Region: Methyltransf_13; pfam08421 441771007486 SAM-dependent methyltransferases [Secondary metabolites biosynthesis, transport, and catabolism / General function prediction only]; Region: SmtA; COG0500 441771007487 Methyltransferase domain; Region: Methyltransf_23; pfam13489 441771007488 C-methyltransferase C-terminal domain; Region: Methyltransf_14; pfam08484 441771007489 putative metalloenzyme radical SAM/SPASM domain maturase; Region: rSAM_Geo_metal; TIGR04311 441771007490 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 441771007491 FeS/SAM binding site; other site 441771007492 Iron-sulfur cluster-binding domain; Region: SPASM; pfam13186 441771007493 Nucleoside-diphosphate-sugar pyrophosphorylase involved in lipopolysaccharide biosynthesis/translation initiation factor 2B, gamma/epsilon subunits (eIF-2Bgamma/eIF-2Bepsilon) [Cell envelope biogenesis, outer membrane / Translation, ribosomal structure...; Region: GCD1; COG1208 441771007494 G1P_cytidylyltransferase catalyzes the production of CDP-D-Glucose; Region: G1P_cytidylyltransferase; cd02524 441771007495 substrate binding site; other site 441771007496 sugar O-acyltransferase, sialic acid O-acetyltransferase NeuD family; Region: NeuD_NnaD; TIGR03570 441771007497 pseudaminic acid synthase; Region: PseI; TIGR03586 441771007498 NeuB family; Region: NeuB; pfam03102 441771007499 C-terminal SAF domain of sialic acid synthetase; Region: SAF_NeuB_like; cd11615 441771007500 NeuB binding interface [polypeptide binding]; other site 441771007501 putative substrate binding site [chemical binding]; other site 441771007502 SpsF is a glycosyltrnasferase implicated in the synthesis of the spore coat; Region: GT2_SpsF; cd02518 441771007503 ligand binding site; other site 441771007504 Predicted hydrolase (HAD superfamily) [General function prediction only]; Region: COG1011 441771007505 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 441771007506 motif II; other site 441771007507 carbamoyl phosphate synthase-like protein; Provisional; Region: PRK12767 441771007508 ATP-grasp domain; Region: ATP-grasp_4; cl17255 441771007509 Nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: WcaG; COG0451 441771007510 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 441771007511 NAD(P) binding site [chemical binding]; other site 441771007512 active site 441771007513 Polysaccharide biosynthesis protein; Region: Polysacc_synt_2; pfam02719 441771007514 UDP-Glcnac (UDP-linked N-acetylglucosamine) inverting 4,6-dehydratase, extended (e) SDRs; Region: UDP_invert_4-6DH_SDR_e; cd05237 441771007515 NAD(P) binding site [chemical binding]; other site 441771007516 homodimer interface [polypeptide binding]; other site 441771007517 substrate binding site [chemical binding]; other site 441771007518 active site 441771007519 UDP-glucose LOS-beta-1,4 glucosyltransferase is required for biosynthesis of lipooligosaccharide; Region: Beta4Glucosyltransferase; cd02511 441771007520 putative metal binding site; other site 441771007521 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 441771007522 TPR motif; other site 441771007523 binding surface 441771007524 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 441771007525 TPR motif; other site 441771007526 binding surface 441771007527 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 441771007528 TPR motif; other site 441771007529 binding surface 441771007530 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2604 441771007531 Glycosyltransferases involved in cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WcaA; COG0463 441771007532 UDP-glucose LOS-beta-1,4 glucosyltransferase is required for biosynthesis of lipooligosaccharide; Region: Beta4Glucosyltransferase; cd02511 441771007533 putative metal binding site; other site 441771007534 TPR repeat; Region: TPR_11; pfam13414 441771007535 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 441771007536 binding surface 441771007537 TPR motif; other site 441771007538 Tetratricopeptide repeat; Region: TPR_16; pfam13432 441771007539 flagellin; Provisional; Region: PRK12804 441771007540 Bacterial flagellin N-terminal helical region; Region: Flagellin_N; pfam00669 441771007541 Bacterial flagellin C-terminal helical region; Region: Flagellin_C; pfam00700 441771007542 flagellin; Provisional; Region: PRK12804 441771007543 Bacterial flagellin N-terminal helical region; Region: Flagellin_N; pfam00669 441771007544 Bacterial flagellin C-terminal helical region; Region: Flagellin_C; pfam00700 441771007545 Flagellar protein FliT; Region: FliT; pfam05400 441771007546 Flagellar hook-associated protein 2 N-terminus; Region: FliD_N; pfam02465 441771007547 Flagellar capping protein [Cell motility and secretion]; Region: FliD; COG1345 441771007548 Flagellar hook-associated protein 2 C-terminus; Region: FliD_C; pfam07195 441771007549 Flagellin-specific chaperone FliS [Cell motility and secretion / Intracellular trafficking and secretion / Posttranslational modification, protein turnover, chaperones]; Region: FliS; COG1516 441771007550 FlaG protein; Region: FlaG; pfam03646 441771007551 carbon storage regulator; Provisional; Region: PRK01712 441771007552 flagellar assembly protein FliW; Provisional; Region: PRK13285 441771007553 flagellar hook-associated protein FlgL; Validated; Region: flgL; PRK07701 441771007554 Bacterial flagellin N-terminal helical region; Region: Flagellin_N; pfam00669 441771007555 Bacterial flagellin C-terminal helical region; Region: Flagellin_C; pfam00700 441771007556 flagellar hook-associated protein FlgK; Validated; Region: flgK; PRK07739 441771007557 Flagella basal body rod protein; Region: Flg_bb_rod; pfam00460 441771007558 Flagellar basal body rod FlgEFG protein C-terminal; Region: Flg_bbr_C; pfam06429 441771007559 FlgN protein; Region: FlgN; pfam05130 441771007560 Anti-sigma-28 factor, FlgM; Region: FlgM; pfam04316 441771007561 flagellar motor switch protein; Validated; Region: PRK08119 441771007562 CheC-like family; Region: CheC; pfam04509 441771007563 CheC-like family; Region: CheC; pfam04509 441771007564 Flagellar motor switch/type III secretory pathway protein [Cell motility and secretion / Intracellular trafficking and secretion]; Region: FliN; COG1886 441771007565 flagellar motor switch protein FliM; Validated; Region: fliM; PRK06666 441771007566 Surface presentation of antigens (SPOA); Region: SpoA; pfam01052 441771007567 Chemotaxis signal transduction protein [Cell motility and secretion / Signal transduction mechanisms]; Region: CheW; COG0835 441771007568 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 441771007569 active site 441771007570 phosphorylation site [posttranslational modification] 441771007571 intermolecular recognition site; other site 441771007572 dimerization interface [polypeptide binding]; other site 441771007573 Chemotaxis protein CheC, inhibitor of MCP methylation [Cell motility and secretion / Signal transduction mechanisms]; Region: CheC; COG1776 441771007574 CheC-like family; Region: CheC; pfam04509 441771007575 CheC-like family; Region: CheC; pfam04509 441771007576 Chemotaxis protein histidine kinase and related kinases [Cell motility and secretion / Signal transduction mechanisms]; Region: CheA; COG0643 441771007577 Histidine Phosphotransfer domain, involved in signalling through a two part component systems in which an autophosphorylating histidine protein kinase serves as a phosphoryl donor to a response regulator protein; the response regulator protein is...; Region: HPT; cd00088 441771007578 putative binding surface; other site 441771007579 active site 441771007580 P2 response regulator binding domain; Region: P2; pfam07194 441771007581 Signal transducing histidine kinase, homodimeric domain; Region: H-kinase_dim; pfam02895 441771007582 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 441771007583 ATP binding site [chemical binding]; other site 441771007584 Mg2+ binding site [ion binding]; other site 441771007585 G-X-G motif; other site 441771007586 CheA regulatory domain; CheA is a histidine protein kinase present in bacteria and archea. Activated by the chemotaxis receptor a histidine phosphoryl group from CheA is passed directly to an aspartate in the response regulator CheY. This signalling...; Region: CheA_reg; cd00731 441771007587 Methylase of chemotaxis methyl-accepting proteins [Cell motility and secretion / Signal transduction mechanisms]; Region: CheR; COG1352 441771007588 CheR methyltransferase, all-alpha domain; Region: CheR_N; pfam03705 441771007589 CheR methyltransferase, SAM binding domain; Region: CheR; pfam01739 441771007590 chemotaxis-specific methylesterase; Provisional; Region: PRK00742 441771007591 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 441771007592 active site 441771007593 phosphorylation site [posttranslational modification] 441771007594 intermolecular recognition site; other site 441771007595 dimerization interface [polypeptide binding]; other site 441771007596 CheB methylesterase; Region: CheB_methylest; pfam01339 441771007597 chemoreceptor glutamine deamidase CheD; Provisional; Region: PRK13490 441771007598 Chemotaxis signal transduction protein [Cell motility and secretion / Signal transduction mechanisms]; Region: CheW; COG0835 441771007599 Jag N-terminus; Region: Jag_N; pfam14804 441771007600 Protein of unknown function (DUF342); Region: DUF342; pfam03961 441771007601 Phosphotransferase system IIC components, glucose/maltose/N-acetylglucosamine-specific [Carbohydrate transport and metabolism]; Region: PtsG; COG1263 441771007602 PTS system N-acetyl glucosamine specific transporter subunits IIABC; Provisional; Region: PRK10255 441771007603 PTS_IIB, PTS system, glucose/sucrose specific IIB subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIB_glc; cd00212 441771007604 active site turn [active] 441771007605 phosphorylation site [posttranslational modification] 441771007606 Phosphotransferase system IIA components [Carbohydrate transport and metabolism]; Region: NagE; COG2190 441771007607 HPr interaction site; other site 441771007608 glycerol kinase (GK) interaction site [polypeptide binding]; other site 441771007609 active site 441771007610 phosphorylation site [posttranslational modification] 441771007611 transcriptional antiterminator BglG; Provisional; Region: PRK09772 441771007612 CAT RNA binding domain; Region: CAT_RBD; smart01061 441771007613 PRD domain; Region: PRD; pfam00874 441771007614 PRD domain; Region: PRD; pfam00874 441771007615 PyridoxaL 5'-Phosphate Dependent Enzymes class IV (PLPDE_IV). This D-amino acid superfamily, one of five classes of PLPDE, consists of branched-chain amino acid aminotransferases (BCAT), D-amino acid transferases (DAAT), and...; Region: PLPDE_IV; cd00449 441771007616 homodimer interface [polypeptide binding]; other site 441771007617 substrate-cofactor binding pocket; other site 441771007618 pyridoxal 5'-phosphate binding site [chemical binding]; other site 441771007619 catalytic residue [active] 441771007620 haloacid dehalogenase-like hydrolase; Region: Hydrolase; pfam00702 441771007621 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 441771007622 motif II; other site 441771007623 Protein of unknown function (DUF1292); Region: DUF1292; pfam06949 441771007624 pyruvate:ferredoxin (flavodoxin) oxidoreductase, homodimeric; Region: pyruv_ox_red; TIGR02176 441771007625 Pyrimidine (PYR) binding domain of pyruvate ferredoxin oxidoreductase (PFOR), indolepyruvate ferredoxin oxidoreductase alpha subunit (IOR-alpha), and related proteins; Region: TPP_PYR_PFOR_IOR-alpha_like; cd07034 441771007626 dimer interface [polypeptide binding]; other site 441771007627 PYR/PP interface [polypeptide binding]; other site 441771007628 TPP binding site [chemical binding]; other site 441771007629 substrate binding site [chemical binding]; other site 441771007630 Pyruvate:ferredoxin oxidoreductase and related 2-oxoacid:ferredoxin oxidoreductases, gamma subunit [Energy production and conversion]; Region: PorG; COG1014 441771007631 Domain of unknown function; Region: EKR; smart00890 441771007632 4Fe-4S dicluster domain; Region: Fer4_8; pfam13183 441771007633 4Fe-4S double cluster binding domain; Region: Fer4_16; pfam13484 441771007634 Thiamine pyrophosphate (TPP family), PFOR_PNO subfamily, TPP-binding module; composed of proteins similar to the single subunit pyruvate ferredoxin oxidoreductase (PFOR) of Desulfovibrio Africanus, present in bacteria and amitochondriate eukaryotes. This...; Region: TPP_PFOR_PNO; cd03377 441771007635 TPP-binding site [chemical binding]; other site 441771007636 dimer interface [polypeptide binding]; other site 441771007637 undecaprenyldiphospho-muramoylpentapeptide beta-N-acetylglucosaminyltransferase; Reviewed; Region: PRK12446 441771007638 MurG is an N-acetylglucosaminyltransferase, the last enzyme involved in the intracellular phase of peptidoglycan biosynthesis. It transfers N-acetyl-D-glucosamine (GlcNAc) from UDP-GlcNAc to the C4 hydroxyl of a lipid-linked N-acetylmuramoyl pentapeptide...; Region: GT1_MurG; cd03785 441771007639 active site 441771007640 homodimer interface [polypeptide binding]; other site 441771007641 PAS domain; Region: PAS_9; pfam13426 441771007642 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 441771007643 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 441771007644 dimer interface [polypeptide binding]; other site 441771007645 phosphorylation site [posttranslational modification] 441771007646 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 441771007647 ATP binding site [chemical binding]; other site 441771007648 Mg2+ binding site [ion binding]; other site 441771007649 G-X-G motif; other site 441771007650 single-stranded-DNA-specific exonuclease RecJ; Region: recJ; TIGR00644 441771007651 DHH family; Region: DHH; pfam01368 441771007652 DHHA1 domain; Region: DHHA1; pfam02272 441771007653 Endonuclease IV [DNA replication, recombination, and repair]; Region: Nfo; COG0648 441771007654 AP endonuclease family 2; These endonucleases play a role in DNA repair. Cleave phosphodiester bonds at apurinic or apyrimidinic sites; the alignment also contains hexulose-6-phosphate isomerases, enzymes that catalyze the epimerization of...; Region: AP2Ec; cd00019 441771007655 AP (apurinic/apyrimidinic) site pocket; other site 441771007656 DNA interaction; other site 441771007657 Metal-binding active site; metal-binding site 441771007658 Protein Disulfide Oxidoreductases and Other Proteins with a Thioredoxin fold; Region: Thioredoxin_like; cl00388 441771007659 Predicted Zn-dependent peptidases [General function prediction only]; Region: PqqL; COG0612 441771007660 Insulinase (Peptidase family M16); Region: Peptidase_M16; pfam00675 441771007661 Peptidase M16 inactive domain; Region: Peptidase_M16_C; pfam05193 441771007662 GtrA-like protein; Region: GtrA; pfam04138 441771007663 DJ-1 family protein; Region: not_thiJ; TIGR01383 441771007664 Type 1 glutamine amidotransferase (GATase1)-like domain found in Human DJ-1; Region: GATase1_DJ-1; cd03135 441771007665 conserved cys residue [active] 441771007666 Glycerol-3-phosphate responsive antiterminator; Region: G3P_antiterm; cl00852 441771007667 DNA topoisomerase IV subunit A; Provisional; Region: PRK13979 441771007668 DNA Topoisomerase, subtype IIA; domain A'; bacterial DNA topoisomerase IV (C subunit, ParC), bacterial DNA gyrases (A subunit, GyrA),mammalian DNA toposiomerases II. DNA topoisomerases are essential enzymes that regulate the conformational changes...; Region: TOP4c; cd00187 441771007669 CAP-like domain; other site 441771007670 active site 441771007671 primary dimer interface [polypeptide binding]; other site 441771007672 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 441771007673 DNA topoisomerase IV subunit B; Reviewed; Region: PRK05559 441771007674 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 441771007675 ATP binding site [chemical binding]; other site 441771007676 Mg2+ binding site [ion binding]; other site 441771007677 G-X-G motif; other site 441771007678 TopoIIA_Trans_DNA_gyrase: Transducer domain, having a ribosomal S5 domain 2-like fold, of the type found in proteins of the type IIA family of DNA topoisomerases similar to the B subunits of E. coli DNA gyrase and E. coli Topoisomerase IV which are; Region: TopoII_Trans_DNA_gyrase; cd00822 441771007679 anchoring element; other site 441771007680 dimer interface [polypeptide binding]; other site 441771007681 ATP binding site [chemical binding]; other site 441771007682 Topoisomerase-primase domain. This is a nucleotidyl transferase/hydrolase domain found in type IA, type IIA and type IIB topoisomerases, bacterial DnaG-type primases, small primase-like proteins from bacteria and archaea, OLD family nucleases from...; Region: TOPRIM; cl00718 441771007683 active site 441771007684 metal binding site [ion binding]; metal-binding site 441771007685 DNA gyrase B subunit, carboxyl terminus; Region: DNA_gyraseB_C; pfam00986 441771007686 Transmembrane subunit (TM) of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which are involved in the uptake of branched-chain amino acids (AAs), as well as TMs of transporters involved in the uptake of...; Region: TM_PBP1_branched-chain-AA_like; cl00454 441771007687 delta-lactam-biosynthetic de-N-acetylase; Region: spore_pdaA; TIGR02884 441771007688 Catalytic NodB homology domain of Streptococcus mutans polysaccharide deacetylase PgdA, Bacillus subtilis YheN, and similar proteins; Region: CE4_SmPgdA_like; cd10944 441771007689 NodB motif; other site 441771007690 active site 441771007691 catalytic site [active] 441771007692 Zn binding site [ion binding]; other site 441771007693 UDP-glucose 4-epimerase [Cell envelope biogenesis, outer membrane]; Region: GalE; COG1087 441771007694 UDP-glucose 4 epimerase, subgroup 1, extended (e) SDRs; Region: UDP_G4E_1_SDR_e; cd05247 441771007695 NAD binding site [chemical binding]; other site 441771007696 homodimer interface [polypeptide binding]; other site 441771007697 active site 441771007698 substrate binding site [chemical binding]; other site 441771007699 NADPH-dependent FMN reductase; Region: FMN_red; cl00438 441771007700 Uncharacterized flavoproteins [Energy production and conversion]; Region: FpaA; COG0426 441771007701 Predicted helicase [General function prediction only]; Region: COG4889 441771007702 Na+-driven multidrug efflux pump [Defense mechanisms]; Region: NorM; COG0534 441771007703 Subfamily of the multidrug and toxic compound extrusion (MATE)-like proteins similar to Streptococcus aureus MepA; Region: MATE_MepA_like; cd13143 441771007704 Cupin domain; Region: Cupin_2; cl17218 441771007705 AraC-type DNA-binding domain-containing proteins [Transcription]; Region: AraC; COG2207 441771007706 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 441771007707 Beta-xylosidase [Carbohydrate transport and metabolism]; Region: XynB; COG3664 441771007708 Microcin C7 self-immunity protein determines resistance to exogenous microcin C7; Region: Peptidase_S66_mccF_like; cd07062 441771007709 putative dimer interface [polypeptide binding]; other site 441771007710 catalytic triad [active] 441771007711 glycerol kinase; Provisional; Region: glpK; PRK00047 441771007712 Escherichia coli glycerol kinase-like proteins; belongs to the FGGY family of carbohydrate kinases; Region: FGGY_EcGK_like; cd07786 441771007713 N- and C-terminal domain interface [polypeptide binding]; other site 441771007714 active site 441771007715 MgATP binding site [chemical binding]; other site 441771007716 catalytic site [active] 441771007717 metal binding site [ion binding]; metal-binding site 441771007718 glycerol binding site [chemical binding]; other site 441771007719 homotetramer interface [polypeptide binding]; other site 441771007720 homodimer interface [polypeptide binding]; other site 441771007721 FBP binding site [chemical binding]; other site 441771007722 protein IIAGlc interface [polypeptide binding]; other site 441771007723 Glycerol uptake facilitator and related permeases (Major Intrinsic Protein Family) [Carbohydrate transport and metabolism]; Region: GlpF; COG0580 441771007724 amphipathic channel; other site 441771007725 Asn-Pro-Ala signature motifs; other site 441771007726 Putative heavy-metal-binding; Region: YbjQ_1; cl00426 441771007727 VanZ like family; Region: VanZ; pfam04892 441771007728 ABC-type multidrug transport system, ATPase component [Defense mechanisms]; Region: CcmA; COG1131 441771007729 ATP-binding cassette domain of the drug resistance transporter and related proteins, subfamily A; Region: ABC_DR_subfamily_A; cd03230 441771007730 Walker A/P-loop; other site 441771007731 ATP binding site [chemical binding]; other site 441771007732 Q-loop/lid; other site 441771007733 ABC transporter signature motif; other site 441771007734 Walker B; other site 441771007735 D-loop; other site 441771007736 H-loop/switch region; other site 441771007737 Predicted transcriptional regulators [Transcription]; Region: COG1725 441771007738 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 441771007739 DNA-binding site [nucleotide binding]; DNA binding site 441771007740 VanZ like family; Region: VanZ; cl01971 441771007741 Hybrid cluster protein (HCP), formerly known as prismane, is thought to play a role in nitrogen metabolism but its specific function is unknown. HCP has three structural domains, an N-terminal alpha-helical domain, and two similar domains comprising a...; Region: HCP; cd01914 441771007742 cubane metal cluster [ion binding]; other site 441771007743 hybrid metal cluster; other site 441771007744 Thermophilic metalloprotease (M29); Region: Peptidase_M29; pfam02073 441771007745 Spore germination B3/ GerAC like, C-terminal; Region: Spore_GerAC; cl19906 441771007746 Amino acid transporters [Amino acid transport and metabolism]; Region: PotE; COG0531 441771007747 Spore germination protein; Region: Spore_permease; cl17796 441771007748 Bacillus/Clostridium GerA spore germination protein; Region: GerA; pfam03323 441771007749 Type 1 glutamine amidotransferase (GATase1)-like domain; Region: GAT_1; cl00020 441771007750 PdxS is a subunit of the pyridoxal 5'-phosphate (PLP) synthase, an important enzyme in deoxyxylulose 5-phosphate (DXP)-independent pathway for de novo biosynthesis of PLP, present in some eubacteria, in archaea, fungi, plants, plasmodia, and some...; Region: pdxS; cd04727 441771007751 active site 441771007752 multimer interface [polypeptide binding]; other site 441771007753 Predicted xylanase/chitin deacetylase [Carbohydrate transport and metabolism]; Region: CDA1; COG0726 441771007754 Catalytic NodB homology domain of Streptococcus mutans polysaccharide deacetylase PgdA, Bacillus subtilis YheN, and similar proteins; Region: CE4_SmPgdA_like; cd10944 441771007755 NodB motif; other site 441771007756 active site 441771007757 catalytic site [active] 441771007758 Zn binding site [ion binding]; other site 441771007759 Superfamily II DNA and RNA helicases [DNA replication, recombination, and repair / Transcription / Translation, ribosomal structure and biogenesis]; Region: SrmB; COG0513 441771007760 DEAD-box helicases. A diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker B motif; Region: DEADc; cd00268 441771007761 ATP binding site [chemical binding]; other site 441771007762 Mg++ binding site [ion binding]; other site 441771007763 motif III; other site 441771007764 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 441771007765 nucleotide binding region [chemical binding]; other site 441771007766 ATP-binding site [chemical binding]; other site 441771007767 RNA recognition motif in the DbpA subfamily of prokaryotic DEAD-box rRNA helicases; Region: RRM_DbpA; cd12252 441771007768 RNA binding site [nucleotide binding]; other site 441771007769 Probable zinc-binding domain; Region: zf-trcl; pfam13451 441771007770 Sensory domain of two-component sensor kinase; Region: Cache_3; pfam14827 441771007771 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cl19050 441771007772 Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer); Region: MA; smart00283 441771007773 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cl19050 441771007774 dimer interface [polypeptide binding]; other site 441771007775 putative CheW interface [polypeptide binding]; other site 441771007776 Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293 441771007777 Ligand Binding Site [chemical binding]; other site 441771007778 4Fe-4S binding domain; Region: Fer4_5; pfam12801 441771007779 The HCP family of iron-sulfur proteins includes hybrid cluster protein (HCP), acetyl-CoA synthase (ACS), and carbon monoxide dehydrogenase (CODH), all of which contain [Fe4-S4] metal clusters at their active sites. These proteins have a conserved...; Region: HCP_like; cl19102 441771007780 4Fe-4S dicluster domain; Region: Fer4_9; pfam13187 441771007781 glutaminase; Provisional; Region: PRK00971 441771007782 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3883 441771007783 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3584 441771007784 Domain of Unknown Function with PDB structure (DUF3862); Region: DUF3862; pfam12978 441771007785 Cache domain; Region: Cache_1; pfam02743 441771007786 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 441771007787 dimerization interface [polypeptide binding]; other site 441771007788 Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer); Region: MA; smart00283 441771007789 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cl19050 441771007790 dimer interface [polypeptide binding]; other site 441771007791 putative CheW interface [polypeptide binding]; other site 441771007792 TraX protein; Region: TraX; cl05434 441771007793 Ribonucleotide Reductase, R2/beta subunit, ferritin-like diiron-binding domain; Region: RNRR2; cd01049 441771007794 dimer interface [polypeptide binding]; other site 441771007795 putative radical transfer pathway; other site 441771007796 diiron center [ion binding]; other site 441771007797 tyrosyl radical; other site 441771007798 Uncharacterized BCR, COG1636; Region: DUF208; cl17782 441771007799 Putative amidase domain; Region: Amidase_6; pfam12671 441771007800 D-alanyl-D-alanine carboxypeptidase; Region: Peptidase_M15_4; pfam13539 441771007801 DNA polymerase IV; Provisional; Region: PRK14133 441771007802 DNA Polymerase IV/Kappa; Region: PolY_Pol_IV_kappa; cd03586 441771007803 active site 441771007804 DNA binding site [nucleotide binding] 441771007805 dihydropyrimidine dehydrogenase subunit B; Validated; Region: PRK08318 441771007806 Dihydropyrimidine dehydrogenase (DHPD) FMN-binding domain. DHPD catalyzes the first step in pyrimidine degradation: the NADPH-dependent reduction of uracil and thymine to the corresponding 5,6-dihydropyrimidines. DHPD contains two FAD, two FMN, and...; Region: DHPD_FMN; cd02940 441771007807 homodimer interface [polypeptide binding]; other site 441771007808 active site 441771007809 FMN binding site [chemical binding]; other site 441771007810 substrate binding site [chemical binding]; other site 441771007811 The HCP family of iron-sulfur proteins includes hybrid cluster protein (HCP), acetyl-CoA synthase (ACS), and carbon monoxide dehydrogenase (CODH), all of which contain [Fe4-S4] metal clusters at their active sites. These proteins have a conserved...; Region: HCP_like; cl19102 441771007812 Dihydroprymidine dehydrogenase domain II, 4Fe-4S cluster; Region: Fer4_20; pfam14691 441771007813 dihydropyrimidine dehydrogenase subunit A; Provisional; Region: PRK11749 441771007814 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl19134 441771007815 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 441771007816 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 441771007817 active site 441771007818 YdcF-like. YdcF-like is a large family of mainly bacterial proteins, with a few members found in fungi, plants, and archaea. Escherichia coli YdcF has been shown to bind S-adenosyl-L-methionine (AdoMet), but a biochemical function has not been...; Region: YdcF-like; cd06259 441771007819 putative active site [active] 441771007820 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cl17220 441771007821 Transcriptional regulators [Transcription]; Region: MarR; COG1846 441771007822 putative DNA binding site [nucleotide binding]; other site 441771007823 putative Zn2+ binding site [ion binding]; other site 441771007824 Excinuclease ATPase subunit [DNA replication, recombination, and repair]; Region: UvrA; COG0178 441771007825 ATP-binding cassette domain I of the excision repair protein UvrA; Region: ABC_UvrA_I; cd03270 441771007826 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 441771007827 Walker A/P-loop; other site 441771007828 ATP binding site [chemical binding]; other site 441771007829 Q-loop/lid; other site 441771007830 ABC transporter signature motif; other site 441771007831 Walker B; other site 441771007832 D-loop; other site 441771007833 H-loop/switch region; other site 441771007834 Protein of unknown function (DUF2628); Region: DUF2628; pfam10947 441771007835 2'-5' RNA ligase; Region: 2_5_ligase; TIGR02258 441771007836 LigT like Phosphoesterase; Region: LigT_PEase; pfam02834 441771007837 LigT like Phosphoesterase; Region: LigT_PEase; pfam02834 441771007838 Carbohydrate binding domain; Region: CBM_25; smart01066 441771007839 Four helix bundle sensory module for signal transduction; Region: 4HB_MCP_1; pfam12729 441771007840 Methyl-accepting chemotaxis protein [Cell motility and secretion / Signal transduction mechanisms]; Region: Tar; COG0840 441771007841 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 441771007842 dimerization interface [polypeptide binding]; other site 441771007843 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cl19050 441771007844 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cl19050 441771007845 dimer interface [polypeptide binding]; other site 441771007846 putative CheW interface [polypeptide binding]; other site 441771007847 Members of the Nudix hydrolase superfamily catalyze the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+, for their activity and contain a highly...; Region: Nudix_Hydrolase_17; cd04676 441771007848 nudix motif; other site 441771007849 Ferric uptake regulator(Fur) and related metalloregulatory proteins; typically iron-dependent, DNA-binding repressors and activators; Region: Fur_like; cd07153 441771007850 metal binding site 2 [ion binding]; metal-binding site 441771007851 putative DNA binding helix; other site 441771007852 metal binding site 1 [ion binding]; metal-binding site 441771007853 dimer interface [polypeptide binding]; other site 441771007854 structural Zn2+ binding site [ion binding]; other site 441771007855 Early set domain associated with the catalytic domain of sugar utilizing enzymes at either the N or C terminus; Region: E_set; cl09101 441771007856 Glyco_18 domain; Region: Glyco_18; smart00636 441771007857 The GH18 (glycosyl hydrolases, family 18) type II chitinases hydrolyze chitin, an abundant polymer of N-acetylglucosamine and have been identified in bacteria, fungi, insects, plants, viruses, and protozoan parasites. The structure of this domain is an...; Region: GH18_chitinase; cd06548 441771007858 active site 441771007859 Early set domain associated with the catalytic domain of sugar utilizing enzymes at either the N or C terminus; Region: E_set; cl09101 441771007860 GlcN6P_deaminase: Glucosamine-6-phosphate (GlcN6P) deaminase subfamily; GlcN6P deaminase catalyzes the reversible conversion of GlcN6P to D-fructose-6-phosphate (Fru6P) and ammonium. The reaction is an aldo-keto isomerization coupled with an amination or...; Region: GlcN6P_deaminase; cd01399 441771007861 active site 441771007862 trimer interface [polypeptide binding]; other site 441771007863 allosteric site; other site 441771007864 active site lid [active] 441771007865 hexamer (dimer of trimers) interface [polypeptide binding]; other site 441771007866 N-acetylglucosamine-6-phosphate deacetylase [Carbohydrate transport and metabolism]; Region: NagA; COG1820 441771007867 N-acetylglucosamine-6-phosphate deacetylase, NagA, catalyzes the hydrolysis of the N-acetyl group of N-acetyl-glucosamine-6-phosphate (GlcNAc-6-P) to glucosamine 6-phosphate and acetate. This is the first committed step in the biosynthetic pathway to...; Region: NagA; cd00854 441771007868 active site 441771007869 dimer interface [polypeptide binding]; other site 441771007870 Transcriptional regulators [Transcription]; Region: PhnF; COG2188 441771007871 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 441771007872 DNA-binding site [nucleotide binding]; DNA binding site 441771007873 UTRA domain; Region: UTRA; pfam07702 441771007874 CAT RNA binding domain; Region: CAT_RBD; smart01061 441771007875 transcriptional antiterminator BglG; Provisional; Region: PRK09772 441771007876 PRD domain; Region: PRD; pfam00874 441771007877 PRD domain; Region: PRD; pfam00874 441771007878 Phosphotransferase system IIA components [Carbohydrate transport and metabolism]; Region: NagE; COG2190 441771007879 HPr interaction site; other site 441771007880 glycerol kinase (GK) interaction site [polypeptide binding]; other site 441771007881 active site 441771007882 phosphorylation site [posttranslational modification] 441771007883 PTS system, N-acetylglucosamine-specific IIBC component; Region: PTS-II-BC-nag; TIGR01998 441771007884 Phosphotransferase system IIC components, glucose/maltose/N-acetylglucosamine-specific [Carbohydrate transport and metabolism]; Region: PtsG; COG1263 441771007885 PTS_IIB, PTS system, glucose/sucrose specific IIB subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIB_glc; cd00212 441771007886 active site turn [active] 441771007887 phosphorylation site [posttranslational modification] 441771007888 Subfamily of the multidrug and toxic compound extrusion (MATE)-like proteins similar to Streptococcus aureus MepA; Region: MATE_MepA_like; cd13143 441771007889 Na+-driven multidrug efflux pump [Defense mechanisms]; Region: NorM; COG0534 441771007890 Na+-driven multidrug efflux pump [Defense mechanisms]; Region: NorM; COG0534 441771007891 Subfamily of the multidrug and toxic compound extrusion (MATE)-like proteins similar to Streptococcus aureus MepA; Region: MATE_MepA_like; cd13143 441771007892 Uncharacterized flavoproteins [Energy production and conversion]; Region: FpaA; COG0426 441771007893 Metallo-beta-lactamase superfamily; Region: Lactamase_B; smart00849 441771007894 NADPH-dependent FMN reductase; Region: FMN_red; cl00438 441771007895 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 441771007896 Short chain acyl-CoA dehydrogenases and eukaryotic short/branched chain acyl-CoA dehydrogenases; Region: SCAD_SBCAD; cd01158 441771007897 FAD binding site [chemical binding]; other site 441771007898 homotetramer interface [polypeptide binding]; other site 441771007899 substrate binding pocket [chemical binding]; other site 441771007900 catalytic base [active] 441771007901 Electron transfer flavoprotein, alpha subunit [Energy production and conversion]; Region: FixB; COG2025 441771007902 Electron transfer flavoprotein FAD-binding domain; Region: ETF_alpha; pfam00766 441771007903 Rubredoxin [Energy production and conversion]; Region: COG1773 441771007904 Rubredoxin; nonheme iron binding domains containing a [Fe(SCys)4] center. Rubredoxins are small nonheme iron proteins. The iron atom is coordinated by four cysteine residues (Fe(S-Cys)4), but iron can also be replaced by cobalt, nickel or zinc. They are...; Region: rubredoxin; cd00730 441771007905 iron binding site [ion binding]; other site 441771007906 Integrase core domain; Region: rve; pfam00665 441771007907 Integrase core domain; Region: rve_2; pfam13333 441771007908 Phosphotransferase system, mannose/fructose/N-acetylgalactosamine-specific component IID [Carbohydrate transport and metabolism]; Region: ManZ; COG3716 441771007909 Domain of unknown function (DUF956); Region: DUF956; pfam06115 441771007910 Acyl CoA:acetate/3-ketoacid CoA transferase, alpha subunit [Lipid metabolism]; Region: AtoD; COG1788 441771007911 Coenzyme A transferase; Region: CoA_trans; cl17247 441771007912 GT_2_like_f is a subfamily of the glycosyltransferase family 2 (GT-2) with unknown function; Region: GT_2_like_f; cd04182 441771007913 Ligand binding site; other site 441771007914 metal-binding site 441771007915 Aerobic-type carbon monoxide dehydrogenase, small subunit CoxS/CutS homologs [Energy production and conversion]; Region: CoxS; COG2080 441771007916 2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207 441771007917 catalytic loop [active] 441771007918 iron binding site [ion binding]; other site 441771007919 [2Fe-2S] binding domain; Region: Fer2_2; pfam01799 441771007920 Aerobic-type carbon monoxide dehydrogenase, middle subunit CoxM/CutM homologs [Energy production and conversion]; Region: CoxM; COG1319 441771007921 FAD binding domain; Region: FAD_binding_4; cl19922 441771007922 CO dehydrogenase flavoprotein C-terminal domain; Region: CO_deh_flav_C; smart01092 441771007923 Aerobic-type carbon monoxide dehydrogenase, large subunit CoxL/CutL homologs [Energy production and conversion]; Region: CoxL; COG1529 441771007924 Aldehyde oxidase and xanthine dehydrogenase, a/b hammerhead domain; Region: Ald_Xan_dh_C; smart01008 441771007925 Molybdopterin-binding domain of aldehyde dehydrogenase; Region: Ald_Xan_dh_C2; pfam02738 441771007926 similar to hypothetical protein; identified by Glimmer3 441771007927 Sodium/hydrogen exchanger family; Region: Na_H_Exchanger; pfam00999 441771007928 Predicted phosphatase/phosphohexomutase [General function prediction only]; Region: COG0637 441771007929 haloacid dehalogenase-like hydrolase; Region: HAD; pfam12710 441771007930 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 441771007931 motif II; other site 441771007932 chloramphenicol/florfenicol resistance protein; Provisional; Region: PRK14453 441771007933 Predicted Fe-S-cluster redox enzyme [General function prediction only]; Region: COG0820 441771007934 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 441771007935 FeS/SAM binding site; other site 441771007936 ATPase components of ABC transporters with duplicated ATPase domains [General function prediction only]; Region: Uup; COG0488 441771007937 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 441771007938 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 441771007939 AAA domain; Region: AAA_23; pfam13476 441771007940 chromosome segregation protein; Provisional; Region: PRK01156 441771007941 Walker A/P-loop; other site 441771007942 ATP binding site [chemical binding]; other site 441771007943 AlwI restriction endonuclease; Region: RE_AlwI; pfam09491 441771007944 Restriction endonuclease FokI, C terminal; Region: Endonuc-FokI_C; pfam09254 441771007945 Cytosine-C5 specific DNA methylases; Methyl transfer reactions play an important role in many aspects of biology. Cytosine-specific DNA methylases are found both in prokaryotes and eukaryotes. DNA methylation, or the covalent addition of a methyl group...; Region: Cyt_C5_DNA_methylase; cd00315 441771007946 cofactor binding site; other site 441771007947 DNA binding site [nucleotide binding] 441771007948 substrate interaction site [chemical binding]; other site 441771007949 Cro/C1-type HTH DNA-binding domain; Region: HTH_26; pfam13443 441771007950 Peptidoglycan recognition proteins (PGRPs) are pattern recognition receptors that bind, and in certain cases, hydrolyze peptidoglycans (PGNs) of bacterial cell walls. PGRPs have been divided into three classes: short PGRPs (PGRP-S), that are small (20...; Region: PGRP; cd06583 441771007951 amidase catalytic site [active] 441771007952 Zn binding residues [ion binding]; other site 441771007953 substrate binding site [chemical binding]; other site 441771007954 Putative peptidoglycan binding domain; Region: PG_binding_1; pfam01471 441771007955 Protein of unknown function (DUF2922); Region: DUF2922; pfam11148 441771007956 Protein of unknown function (DUF1659); Region: DUF1659; pfam07872 441771007957 YvrJ protein family; Region: YvrJ; pfam12841 441771007958 RNA polymerase sigma factor, sigma-70 family; Region: sigma70-ECF; TIGR02937 441771007959 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 441771007960 Protein of unknown function (DUF3267); Region: DUF3267; pfam11667 441771007961 Putative primosome component and related proteins [DNA replication, recombination, and repair]; Region: DnaD; COG3935 441771007962 Replication initiation and membrane attachment; Region: DnaB_2; pfam07261 441771007963 Helix-turn-helix domain; Region: HTH_17; pfam12728 441771007964 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 441771007965 non-specific DNA binding site [nucleotide binding]; other site 441771007966 salt bridge; other site 441771007967 sequence-specific DNA binding site [nucleotide binding]; other site 441771007968 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 441771007969 non-specific DNA binding site [nucleotide binding]; other site 441771007970 salt bridge; other site 441771007971 sequence-specific DNA binding site [nucleotide binding]; other site 441771007972 AP2-like DNA-binding integrase domain; Region: Integrase_AP2; pfam14657 441771007973 Site-specific recombinase XerD [DNA replication, recombination, and repair]; Region: XerD; COG4974 441771007974 Phage integrase, N-terminal SAM-like domain; Region: Phage_int_SAM_3; pfam14659 441771007975 phiLC3 phage and phage-related integrases, site-specific recombinases, DNA breaking-rejoining enzymes, C-terminal catalytic domain. This CD includes various bacterial (mainly gram positive) and phage integrases, including those similar to Lactococcus...; Region: INT_phiLC3_C; cd01189 441771007976 Int/Topo IB signature motif; other site 441771007977 TRAM domain; Region: TRAM; cl01282 441771007978 SAM-dependent methyltransferases related to tRNA (uracil-5-)-methyltransferase [Translation, ribosomal structure and biogenesis]; Region: TrmA; COG2265 441771007979 4-alpha-glucanotransferase; Region: Glyco_hydro_77; cl00711 441771007980 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 441771007981 S-adenosylmethionine binding site [chemical binding]; other site 441771007982 Uncharacterized protein conserved in archaea (DUF2114); Region: DUF2114; cl01680 441771007983 Solute carrier families 5 and 6-like; solute binding domain; Region: SLC5-6-like_sbd; cl00456 441771007984 Phosphoglycerol transferase and related proteins, alkaline phosphatase superfamily [Cell envelope biogenesis, outer membrane]; Region: MdoB; COG1368 441771007985 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cl00462 441771007986 Sulfatase; Region: Sulfatase; pfam00884 441771007987 hypothetical protein; Provisional; Region: PRK10621 441771007988 lumazine synthase (6,7-dimethyl-8-ribityllumazine synthase, LS), catalyzes the penultimate step in the biosynthesis of riboflavin (vitamin B2); type-I; Region: Lumazine_synthase-I; cd09209 441771007989 homopentamer interface [polypeptide binding]; other site 441771007990 active site 441771007991 bifunctional 3,4-dihydroxy-2-butanone 4-phosphate synthase/GTP cyclohydrolase II protein; Provisional; Region: PRK09311 441771007992 3,4-dihydroxy-2-butanone 4-phosphate synthase; Region: DHBP_synthase; pfam00926 441771007993 GTP cyclohydrolase II (RibA). GTP cyclohydrolase II catalyzes the conversion of GTP to 2,5-diamino-6-ribosylamino-4(3H)-pyrimidinone 5' phosphate, formate, pyrophosphate (APy), and GMP in the biosynthetic pathway of riboflavin. Riboflavin is the...; Region: GTP_cyclohydro2; cd00641 441771007994 dimerization interface [polypeptide binding]; other site 441771007995 active site 441771007996 riboflavin synthase subunit alpha; Provisional; Region: PRK09289 441771007997 Lumazine binding domain; Region: Lum_binding; pfam00677 441771007998 Lumazine binding domain; Region: Lum_binding; pfam00677 441771007999 riboflavin biosynthesis protein RibD; Region: eubact_ribD; TIGR00326 441771008000 Riboflavin-specific deaminase. Riboflavin biosynthesis protein RibD (Diaminohydroxyphosphoribosylaminopyrimidine deaminase) catalyzes the deamination of 2,5-diamino-6-ribosylamino-4(3H)-pyrimidinone 5'-phosphate, which is an intermediate step in the...; Region: Riboflavin_deaminase-reductase; cd01284 441771008001 catalytic motif [active] 441771008002 Zn binding site [ion binding]; other site 441771008003 Pyrimidine reductase, riboflavin biosynthesis [Coenzyme metabolism]; Region: RibD; COG1985 441771008004 Xaa-His dipeptidase; Region: aa-his-dipept; TIGR01893 441771008005 M20 Peptidase D has specificity for beta-alanyl-L-histidine dipeptide; Region: M20_pepD; cd03890 441771008006 metal binding site [ion binding]; metal-binding site 441771008007 dimer interface [polypeptide binding]; other site 441771008008 Metallo-beta-lactamase superfamily; Region: Lactamase_B; smart00849 441771008009 magnesium-transporting ATPase; Provisional; Region: PRK15122 441771008010 Cation transporter/ATPase, N-terminus; Region: Cation_ATPase_N; pfam00690 441771008011 E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122 441771008012 Putative hydrolase of sodium-potassium ATPase alpha subunit; Region: Hydrolase_like2; pfam13246 441771008013 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 441771008014 motif II; other site 441771008015 Cation transporting ATPase, C-terminus; Region: Cation_ATPase_C; pfam00689 441771008016 HNH nucleases; HNH endonuclease signature which is found in viral, prokaryotic, and eukaryotic proteins. The alignment includes members of the large group of homing endonucleases, yeast intron 1 protein, MutS, as well as bacterial colicins, pyocins, and...; Region: HNHc; cd00085 441771008017 active site 441771008018 phosphoribosylamine--glycine ligase; Provisional; Region: PRK00885 441771008019 Phosphoribosylglycinamide synthetase, N domain; Region: GARS_N; pfam02844 441771008020 Phosphoribosylglycinamide synthetase, ATP-grasp (A) domain; Region: GARS_A; pfam01071 441771008021 Phosphoribosylglycinamide synthetase, C domain; Region: GARS_C; pfam02843 441771008022 bifunctional phosphoribosylaminoimidazolecarboxamide formyltransferase/IMP cyclohydrolase; Provisional; Region: purH; PRK00881 441771008023 Inosine monophosphate cyclohydrolase domain. This is the N-terminal domain in the purine biosynthesis pathway protein ATIC (purH). The bifunctional ATIC protein contains a C-terminal ATIC formylase domain that formylates...; Region: IMPCH; cd01421 441771008024 purine monophosphate binding site [chemical binding]; other site 441771008025 dimer interface [polypeptide binding]; other site 441771008026 putative catalytic residues [active] 441771008027 AICARFT/IMPCHase bienzyme; Region: AICARFT_IMPCHas; smart00798 441771008028 Phosphoribosylglycinamide formyltransferase (GAR transformylase, GART); Region: FMT_core_GART; cd08645 441771008029 active site 441771008030 substrate binding site [chemical binding]; other site 441771008031 cosubstrate binding site; other site 441771008032 catalytic site [active] 441771008033 phosphoribosylaminoimidazole synthetase; Provisional; Region: PRK05385 441771008034 PurM (Aminoimidazole Ribonucleotide [AIR] synthetase), one of eleven enzymes required for purine biosynthesis, catalyzes the conversion of formylglycinamide ribonucleotide (FGAM) and ATP to AIR, ADP, and Pi, the fifth step in de novo purine biosynthesis; Region: PurM; cd02196 441771008035 dimerization interface [polypeptide binding]; other site 441771008036 putative ATP binding site [chemical binding]; other site 441771008037 amidophosphoribosyltransferase; Provisional; Region: PRK05793 441771008038 Glutamine amidotransferases class-II (GN-AT)_GPAT- type. This domain is found at the N-terminus of glutamine phosphoribosylpyrophosphate (Prpp) amidotransferase (GPATase) . The glutaminase domain catalyzes amide nitrogen transfer from glutamine to the...; Region: GPATase_N; cd00715 441771008039 active site 441771008040 tetramer interface [polypeptide binding]; other site 441771008041 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 441771008042 active site 441771008043 bacterial and archaeal 5-aminoimidazole-4-(N-succinylcarboxamide) ribonucleotide (SAICAR) synthase; Region: SAICAR_synt_PurC; cd01415 441771008044 ATP binding site [chemical binding]; other site 441771008045 active site 441771008046 substrate binding site [chemical binding]; other site 441771008047 Phosphoribosylcarboxyaminoimidazole (NCAIR) mutase [Nucleotide transport and metabolism]; Region: PurE; COG0041 441771008048 selenium-dependent molybdenum hydroxylase 1; Region: Se_dep_Molyb_1; TIGR03311 441771008049 2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207 441771008050 catalytic loop [active] 441771008051 iron binding site [ion binding]; other site 441771008052 [2Fe-2S] binding domain; Region: Fer2_2; pfam01799 441771008053 Aldehyde oxidase and xanthine dehydrogenase, a/b hammerhead domain; Region: Ald_Xan_dh_C; smart01008 441771008054 Molybdopterin-binding domain of aldehyde dehydrogenase; Region: Ald_Xan_dh_C2; pfam02738 441771008055 putative selenium metabolism hydrolase; Region: selenium_YgeY; TIGR03526 441771008056 M20 Peptidases with similarity to acetylornithine deacetylases and succinyl-diaminopimelate desuccinylases; Region: M20_ArgE_DapE_like4; cd05649 441771008057 putative metal binding site [ion binding]; other site 441771008058 putative dimer interface [polypeptide binding]; other site 441771008059 putative chlorohydrolase/aminohydrolase; Validated; Region: PRK07203 441771008060 TRZ/ATZ family contains enzymes from the atrazine degradation pathway and related hydrolases. Atrazine, a chlorinated herbizide, can be catabolized by a variety of different bacteria. The first three steps of the atrazine dehalogenation pathway are...; Region: ATZ_TRZ_like; cd01298 441771008061 active site 441771008062 putative substrate binding pocket [chemical binding]; other site 441771008063 putative selenate reductase, YgfK subunit; Region: Se_ygfK; TIGR03315 441771008064 The HCP family of iron-sulfur proteins includes hybrid cluster protein (HCP), acetyl-CoA synthase (ACS), and carbon monoxide dehydrogenase (CODH), all of which contain [Fe4-S4] metal clusters at their active sites. These proteins have a conserved...; Region: HCP_like; cl19102 441771008065 Medium chain reductase/dehydrogenase (MDR)/zinc-dependent alcohol dehydrogenase-like family; Region: MDR; cl16912 441771008066 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl19134 441771008067 4Fe-4S dicluster domain; Region: Fer4_17; pfam13534 441771008068 aspartate/ornithine carbamoyltransferase family protein; Validated; Region: PRK07200 441771008069 Aspartate/ornithine carbamoyltransferase, carbamoyl-P binding domain; Region: OTCace_N; pfam02729 441771008070 Aspartate/ornithine carbamoyltransferase, Asp/Orn binding domain; Region: OTCace; pfam00185 441771008071 phenylhydantoinase; Validated; Region: PRK08323 441771008072 D-hydantoinases (D-HYD) also called dihydropyrimidases (DHPase) and related proteins; DHPases are a family of enzymes that catalyze the reversible hydrolytic ring opening of the amide bond in five- or six-membered cyclic diamides, like dihydropyrimidine...; Region: D-HYD; cd01314 441771008073 tetramer interface [polypeptide binding]; other site 441771008074 active site 441771008075 Sulfate transporter family; Region: Sulfate_transp; cl19250 441771008076 xanthine permease; Region: pbuX; TIGR03173 441771008077 Tryptophan synthase beta superfamily (fold type II); this family of pyridoxal phosphate (PLP)-dependent enzymes catalyzes beta-replacement and beta-elimination reactions. This CD corresponds to aminocyclopropane-1-carboxylate deaminase (ACCD), tryptophan...; Region: Trp-synth-beta_II; cd00640 441771008078 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 441771008079 catalytic residue [active] 441771008080 Transcriptional regulator containing PAS, AAA-type ATPase, and DNA-binding domains [Transcription / Signal transduction mechanisms]; Region: RocR; COG3829 441771008081 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 441771008082 Walker A motif; other site 441771008083 ATP binding site [chemical binding]; other site 441771008084 Walker B motif; other site 441771008085 arginine finger; other site 441771008086 Bacterial regulatory protein, Fis family; Region: HTH_8; pfam02954 441771008087 probable selenium-dependent hydroxylase accessory protein YqeC; Region: TIGR03172 441771008088 GT_2_like_f is a subfamily of the glycosyltransferase family 2 (GT-2) with unknown function; Region: GT_2_like_f; cd04182 441771008089 Ligand binding site; other site 441771008090 metal-binding site 441771008091 selenium-dependent molybdenum hydroxylase system protein, YqeB family; Region: matur_yqeB; TIGR03309 441771008092 Xanthine and CO dehydrogenases maturation factor, XdhC/CoxF family [Posttranslational modification, protein turnover, chaperones]; Region: XdhC; COG1975 441771008093 XdhC and CoxI family; Region: XdhC_CoxI; pfam02625 441771008094 XdhC Rossmann domain; Region: XdhC_C; pfam13478 441771008095 ATPases associated with a variety of cellular activities; Region: AAA; smart00382 441771008096 NTPase; Region: NTPase_1; pfam03266 441771008097 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550 441771008098 ABC-ATPase subunit interface; other site 441771008099 dimer interface [polypeptide binding]; other site 441771008100 putative PBP binding regions; other site 441771008101 ABC-type cobalamin/Fe3+-siderophores transport systems, ATPase components [Inorganic ion transport and metabolism / Coenzyme metabolism]; Region: FepC; COG1120 441771008102 ATP-binding component of iron-siderophores, vitamin B12 and hemin transporters and related proteins; Region: ABC_Iron-Siderophores_B12_Hemin; cd03214 441771008103 Walker A/P-loop; other site 441771008104 ATP binding site [chemical binding]; other site 441771008105 Q-loop/lid; other site 441771008106 ABC transporter signature motif; other site 441771008107 Walker B; other site 441771008108 D-loop; other site 441771008109 H-loop/switch region; other site 441771008110 ABC-type Fe3+-hydroxamate transport system, periplasmic component [Inorganic ion transport and metabolism]; Region: FepB; COG0614 441771008111 Helical backbone metal receptor (TroA-like domain). These proteins have been shown to function in the ABC transport of ferric siderophores and metal ions such as Mn2+, Fe3+, Cu2+ and/or Zn2+. Their ligand binding site is formed in the interface between...; Region: TroA-like; cl00262 441771008112 intersubunit interface [polypeptide binding]; other site 441771008113 ALIX V-shaped domain binding to HIV; Region: ALIX_LYPXL_bnd; pfam13949 441771008114 SGNH_hydrolase, or GDSL_hydrolase, is a diverse family of lipases and esterases. The tertiary fold of the enzyme is substantially different from that of the alpha/beta hydrolase family and unique among all known hydrolases; its active site closely...; Region: SGNH_hydrolase; cl01053 441771008115 active site 441771008116 catalytic triad [active] 441771008117 oxyanion hole [active] 441771008118 YdcF-like. YdcF-like is a large family of mainly bacterial proteins, with a few members found in fungi, plants, and archaea. Escherichia coli YdcF has been shown to bind S-adenosyl-L-methionine (AdoMet), but a biochemical function has not been...; Region: YdcF-like; cd06259 441771008119 putative active site [active] 441771008120 Xanthine/uracil/vitamin C permease [Nucleotide transport and metabolism]; Region: COG2252 441771008121 Na+/alanine symporter [Amino acid transport and metabolism]; Region: AlsT; COG1115 441771008122 Superfamily I DNA and RNA helicases [General function prediction only]; Region: COG3973 441771008123 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 441771008124 ATP binding site [chemical binding]; other site 441771008125 Predicted tRNA(5-methylaminomethyl-2-thiouridylate) methyltransferase, contains the PP-loop ATPase domain [Translation, ribosomal structure and biogenesis]; Region: TrmU; COG0482 441771008126 tRNA methyl transferase. This family represents tRNA(5-methylaminomethyl-2-thiouridine)-methyltransferase which is involved in the biosynthesis of the modified nucleoside 5-methylaminomethyl-2-thiouridine present in the wobble position of some tRNAs; Region: tRNA_Me_trans; cd01998 441771008127 Ligand Binding Site [chemical binding]; other site 441771008128 M20 Peptidase Arginine utilization protein, RocB; Region: M20_ArgE_RocB; cd05654 441771008129 putative metal binding site [ion binding]; other site 441771008130 putative dimer interface [polypeptide binding]; other site 441771008131 GAF domain-containing protein [Signal transduction mechanisms]; Region: COG1956 441771008132 Hemolysins and related proteins containing CBS domains [General function prediction only]; Region: TlyC; COG1253 441771008133 Domain of unknown function DUF21; Region: DUF21; pfam01595 441771008134 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains associated with the CorC_HlyC domain. CorC_HlyC is a transporter associated domain. This small domain is found in Na+/H+ antiporters, in proteins involved in...; Region: CBS_pair_CorC_HlyC_assoc; cd04590 441771008135 Transporter associated domain; Region: CorC_HlyC; pfam03471 441771008136 Domain of unknown function DUF77; Region: DUF77; pfam01910 441771008137 thiamine biosynthesis protein ThiC; Provisional; Region: PRK13352 441771008138 amidophosphoribosyltransferase; Provisional; Region: PRK05793 441771008139 Glutamine amidotransferases class-II (GN-AT)_GPAT- type. This domain is found at the N-terminus of glutamine phosphoribosylpyrophosphate (Prpp) amidotransferase (GPATase) . The glutaminase domain catalyzes amide nitrogen transfer from glutamine to the...; Region: GPATase_N; cd00715 441771008140 active site 441771008141 tetramer interface [polypeptide binding]; other site 441771008142 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 441771008143 active site 441771008144 Protein of unknown function (DUF503); Region: DUF503; pfam04456 441771008145 ABC-2 family transporter protein; Region: ABC2_membrane_5; pfam13346 441771008146 ABC-2 family transporter protein; Region: ABC2_membrane_5; pfam13346 441771008147 ABC-type multidrug transport system, ATPase component [Defense mechanisms]; Region: CcmA; COG1131 441771008148 ATP-binding cassette domain of the drug resistance transporter and related proteins, subfamily A; Region: ABC_DR_subfamily_A; cd03230 441771008149 Walker A/P-loop; other site 441771008150 ATP binding site [chemical binding]; other site 441771008151 Q-loop/lid; other site 441771008152 ABC transporter signature motif; other site 441771008153 Walker B; other site 441771008154 D-loop; other site 441771008155 H-loop/switch region; other site 441771008156 Predicted transcriptional regulators [Transcription]; Region: COG1725 441771008157 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 441771008158 DNA-binding site [nucleotide binding]; DNA binding site 441771008159 3,4-dihydroxy-2-butanone 4-phosphate synthase; Provisional; Region: ribB; PRK03353 441771008160 Ferredoxin [Energy production and conversion]; Region: COG1146 441771008161 Ferredoxin [Energy production and conversion]; Region: Fer; COG1141 441771008162 effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038 441771008163 cAMP-binding proteins - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases [Signal transduction mechanisms]; Region: Crp; COG0664 441771008164 ligand binding site [chemical binding]; other site 441771008165 flexible hinge region; other site 441771008166 Crp-like helix-turn-helix domain; Region: HTH_Crp_2; pfam13545 441771008167 Cell Wall Hydrolase; Region: Hydrolase_2; pfam07486 441771008168 Uncharacterized conserved protein, contains double-stranded beta-helix domain [Function unknown]; Region: COG1917 441771008169 Predicted membrane protein [Function unknown]; Region: COG1511 441771008170 YhgE/Pip N-terminal domain; Region: pip_yhgE_Nterm; cl19580 441771008171 V antigen (LcrV) protein; Region: LcrV; pfam04792 441771008172 YhgE/Pip C-terminal domain; Region: pip_yhgE_Cterm; TIGR03062 441771008173 Glycerophosphoryl diester phosphodiesterase [Energy production and conversion]; Region: UgpQ; COG0584 441771008174 Glycerophosphodiester phosphodiesterase domain of Thermoanaerobacter tengcongensis and similar proteins; Region: GDPD_TtGDE_like; cd08563 441771008175 active site 441771008176 catalytic site [active] 441771008177 metal binding site [ion binding]; metal-binding site 441771008178 dimer interface [polypeptide binding]; other site 441771008179 Glycyl-tRNA synthetase, beta subunit [Translation, ribosomal structure and biogenesis]; Region: GlyS; COG0751 441771008180 Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl18945 441771008181 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 441771008182 catalytic residue [active] 441771008183 Zn-ribbon protein, possibly nucleic acid-binding [General function prediction only]; Region: COG1579 441771008184 TMPIT-like protein; Region: TMPIT; pfam07851 441771008185 Putative zinc ribbon domain; Region: DUF164; pfam02591 441771008186 NIF3 (NGG1p interacting factor 3); Region: NIF3; pfam01784 441771008187 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl17173 441771008188 Bacterial PH domain; Region: bPH_5; pfam10882 441771008189 RNA polymerase sigma factor RpoD; Validated; Region: PRK09210 441771008190 Sigma-70 factor, region 1.1; Region: Sigma70_r1_1; pfam03979 441771008191 Sigma-70 factor, region 1.2; Region: Sigma70_r1_2; pfam00140 441771008192 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 441771008193 Sigma-70 region 3; Region: Sigma70_r3; pfam04539 441771008194 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 441771008195 DNA binding residues [nucleotide binding] 441771008196 DNA primase; Validated; Region: dnaG; PRK05667 441771008197 CHC2 zinc finger; Region: zf-CHC2; pfam01807 441771008198 DNA primase catalytic core, N-terminal domain; Region: Toprim_N; pfam08275 441771008199 TOPRIM_DnaG_primases: The topoisomerase-primase (TORPIM) nucleotidyl transferase/hydrolase domain found in the active site regions of proteins similar to Escherichia coli DnaG. Primases synthesize RNA primers for the initiation of DNA replication. DnaG...; Region: TOPRIM_DnaG_primases; cd03364 441771008200 active site 441771008201 metal binding site [ion binding]; metal-binding site 441771008202 interdomain interaction site; other site 441771008203 DnaB-helicase binding domain of primase; Region: DnaB_bind; pfam10410 441771008204 deoxyguanosinetriphosphate triphosphohydrolase-like protein; Provisional; Region: PRK01286 441771008205 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 441771008206 Zn2+ binding site [ion binding]; other site 441771008207 Mg2+ binding site [ion binding]; other site 441771008208 Phosphohydrolase-associated domain; Region: HD_assoc; pfam13286 441771008209 Aminoglycoside 3'-phosphotransferase (APH) and Choline Kinase (ChoK) family. The APH/ChoK family is part of a larger superfamily that includes the catalytic domains of other kinases, such as the typical serine/threonine/tyrosine protein kinases (PKs)...; Region: APH_ChoK_like; cl17270 441771008210 Phosphotransferase enzyme family; Region: APH; pfam01636 441771008211 active site 441771008212 ATP binding site [chemical binding]; other site 441771008213 substrate binding site [chemical binding]; other site 441771008214 pyruvate phosphate dikinase; Provisional; Region: PRK09279 441771008215 Pyruvate phosphate dikinase, PEP/pyruvate binding domain; Region: PPDK_N; pfam01326 441771008216 PEP-utilizing enzyme, mobile domain; Region: PEP-utilizers; pfam00391 441771008217 PEP-utilizing enzyme, TIM barrel domain; Region: PEP-utilizers_C; pfam02896 441771008218 HTH domain; Region: HTH_11; pfam08279 441771008219 FOG: CBS domain [General function prediction only]; Region: COG0517 441771008220 The CBS domain, named after human CBS, is a small domain originally identified in cystathionine beta-synthase and is subsequently found in a wide range of different proteins. CBS domains usually occur in tandem repeats. They associate to form a so-called...; Region: CBS_pair_4; cd04617 441771008221 SIS domain. SIS (Sugar ISomerase) domains are found in many phosphosugar isomerases and phosphosugar binding proteins. SIS domains are also found in proteins that regulate the expression of genes involved in synthesis of phosphosugars; Region: SIS; cl00389 441771008222 Domain of unknown function (DUF4342); Region: DUF4342; pfam14242 441771008223 Recombination protein O C terminal; Region: RecO_C; pfam02565 441771008224 GTPase Era; Reviewed; Region: era; PRK00089 441771008225 E. coli Ras-like protein (Era) is a multifunctional GTPase; Region: Era; cd04163 441771008226 G1 box; other site 441771008227 GTP/Mg2+ binding site [chemical binding]; other site 441771008228 Switch I region; other site 441771008229 G2 box; other site 441771008230 Switch II region; other site 441771008231 G3 box; other site 441771008232 G4 box; other site 441771008233 G5 box; other site 441771008234 KH domain; Region: KH_2; pfam07650 441771008235 Cytidine deaminase [Nucleotide transport and metabolism]; Region: Cdd; COG0295 441771008236 Cytidine deaminase zinc-binding domain. These enzymes are Zn dependent. The zinc ion in the active site plays a central role in the proposed catalytic mechanism, activating a water molecule to form a hydroxide ion that performs a nucleophilic attack on...; Region: cytidine_deaminase; cd01283 441771008237 active site 441771008238 catalytic motif [active] 441771008239 Zn binding site [ion binding]; other site 441771008240 Integral membrane undecaprenol kinase domain co-occurring with type 2 phosphatidic acid phosphatase-like domains; Region: UDPK_IM_PAP2_like; cd14266 441771008241 trimer interface [polypeptide binding]; other site 441771008242 putative active site [active] 441771008243 Zn binding site [ion binding]; other site 441771008244 Membrane-associated phospholipid phosphatase [Lipid metabolism]; Region: PgpB; COG0671 441771008245 PAP2_like proteins, diacylglycerol_kinase like sub-family. In some prokaryotes, PAP2_like phosphatase domains appear fused to E. coli DAGK-like trans-membrane diacylglycerol kinase domains. The cellular function of these architectures remains to be...; Region: PAP2_diacylglycerolkinase; cd03383 441771008246 active site 441771008247 metal-binding heat shock protein; Provisional; Region: PRK00016 441771008248 Predicted membrane-associated HD superfamily hydrolase [General function prediction only]; Region: COG1480 441771008249 7TM-HD extracellular; Region: 7TMR-HDED; pfam07697 441771008250 7TM receptor with intracellular HD hydrolase; Region: 7TM-7TMR_HD; pfam07698 441771008251 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 441771008252 Zn2+ binding site [ion binding]; other site 441771008253 Mg2+ binding site [ion binding]; other site 441771008254 Putative stage IV sporulation protein YqfD; Region: YqfD; pfam06898 441771008255 sporulation protein YqfD; Region: spore_yqfD; TIGR02876 441771008256 sporulation protein YqfC; Region: spore_yqfC; TIGR02856 441771008257 Yqey-like protein; Region: YqeY; pfam09424 441771008258 30S ribosomal protein S21; Reviewed; Region: rpsU; PRK00270 441771008259 Protein Kinase C Interacting protein related (PKCI): PKCI and related proteins belong to the ubiquitous HIT family of hydrolases that act on alpha-phosphates of ribonucleotides. The members of this subgroup have a conserved HxHxHxx motif (x is a...; Region: PKCI_related; cd01276 441771008260 nucleotide binding site/active site [active] 441771008261 HIT family signature motif; other site 441771008262 catalytic residue [active] 441771008263 2-methylthioadenine synthetase [Translation, ribosomal structure and biogenesis]; Region: MiaB; COG0621 441771008264 Uncharacterized protein family UPF0004; Region: UPF0004; pfam00919 441771008265 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 441771008266 FeS/SAM binding site; other site 441771008267 16S ribosomal RNA methyltransferase RsmE; Provisional; Region: PRK11713 441771008268 Ribosomal protein L11 methyltransferase (PrmA); Region: PrmA; pfam06325 441771008269 DNA methylase; Region: N6_N4_Mtase; cl17433 441771008270 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 441771008271 S-adenosylmethionine binding site [chemical binding]; other site 441771008272 chaperone protein DnaJ; Provisional; Region: PRK14297 441771008273 DnaJ domain or J-domain. DnaJ/Hsp40 (heat shock protein 40) proteins are highly conserved and play crucial roles in protein translation, folding, unfolding, translocation, and degradation. They act primarily by stimulating the ATPase activity of Hsp70s; Region: DnaJ; cd06257 441771008274 HSP70 interaction site [polypeptide binding]; other site 441771008275 C-terminal substrate binding domain of DnaJ and HSP40; Region: DnaJ_C; cd10747 441771008276 substrate binding site [polypeptide binding]; other site 441771008277 Zinc finger domain of DnaJ and HSP40; Region: DnaJ_zf; cd10719 441771008278 Zn binding sites [ion binding]; other site 441771008279 dimer interface [polypeptide binding]; other site 441771008280 molecular chaperone DnaK; Provisional; Region: dnaK; PRK00290 441771008281 Nucleotide-binding domain of human HSPA9 and similar proteins; Region: HSPA9-Ssq1-like_NBD; cd10234 441771008282 nucleotide binding site [chemical binding]; other site 441771008283 NEF interaction site [polypeptide binding]; other site 441771008284 SBD interface [polypeptide binding]; other site 441771008285 GrpE is the adenine nucleotide exchange factor of DnaK (Hsp70)-type ATPases. The GrpE dimer binds to the ATPase domain of Hsp70 catalyzing the dissociation of ADP, which enables rebinding of ATP, one step in the Hsp70 reaction cycle in protein folding; Region: GrpE; cd00446 441771008286 dimer interface [polypeptide binding]; other site 441771008287 hsp70 (ATPase domain) interactions [polypeptide binding]; other site 441771008288 heat-inducible transcription repressor; Provisional; Region: hrcA; PRK00082 441771008289 Winged helix-turn-helix transcription repressor, HrcA DNA-binding; Region: HrcA_DNA-bdg; pfam03444 441771008290 HrcA protein C terminal domain; Region: HrcA; pfam01628 441771008291 coproporphyrinogen III oxidase; Provisional; Region: PRK05799 441771008292 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 441771008293 FeS/SAM binding site; other site 441771008294 HemN C-terminal domain; Region: HemN_C; pfam06969 441771008295 GTP-binding protein LepA; Provisional; Region: PRK05433 441771008296 LepA also known as Elongation Factor 4 (EF4); Region: LepA; cd01890 441771008297 G1 box; other site 441771008298 putative GEF interaction site [polypeptide binding]; other site 441771008299 GTP/Mg2+ binding site [chemical binding]; other site 441771008300 Switch I region; other site 441771008301 G2 box; other site 441771008302 G3 box; other site 441771008303 Switch II region; other site 441771008304 G4 box; other site 441771008305 G5 box; other site 441771008306 lepA_II: This subfamily represents the domain II of LepA, a GTP-binding protein localized in the cytoplasmic membrane. The N-terminal domain of LepA shares regions of homology to translation factors. In terms of interaction with the ribosome, EF-G, EF-Tu...; Region: lepA_II; cd03699 441771008307 Elongation Factor G, domain II; Region: EFG_II; pfam14492 441771008308 lepA_C: This family represents the C-terminal region of LepA, a GTP-binding protein localized in the cytoplasmic membrane. LepA is ubiquitous in Bacteria and Eukaryota (e.g. Saccharomyces cerevisiae GUF1p), but is missing from Archaea. LepA exhibits...; Region: lepA_C; cd03709 441771008309 GTP-binding protein LepA C-terminus; Region: LepA_C; pfam06421 441771008310 Stage II sporulation protein P (SpoIIP); Region: SpoIIP; pfam07454 441771008311 stage II sporulation protein P; Region: spore_II_P; TIGR02867 441771008312 germination protease; Provisional; Region: PRK12362 441771008313 30S ribosomal protein S20; Reviewed; Region: rpsT; PRK00239 441771008314 DNA polymerase III subunit delta; Reviewed; Region: holA; PRK05574 441771008315 DNA polymerase III, delta subunit; Region: DNA_pol3_delta; cl19912 441771008316 Predicted membrane metal-binding protein [General function prediction only]; Region: ComEC; COG0658 441771008317 Competence protein; Region: Competence; pfam03772 441771008318 Cation transporter/ATPase, N-terminus; Region: Cation_ATPase_N; pfam00690 441771008319 ATPase, P-type (transporting), HAD superfamily, subfamily IC; Region: ATPase_P-type; TIGR01494 441771008320 E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122 441771008321 Putative hydrolase of sodium-potassium ATPase alpha subunit; Region: Hydrolase_like2; pfam13246 441771008322 Soluble P-type ATPase [General function prediction only]; Region: COG4087 441771008323 Protein of unknown function (DUF1538); Region: DUF1538; pfam07556 441771008324 Protein of unknown function (DUF1538); Region: DUF1538; pfam07556 441771008325 Selenocysteine-specific translation elongation factor [Translation, ribosomal structure and biogenesis]; Region: SelB; COG3276 441771008326 SelB, the dedicated elongation factor for delivery of selenocysteinyl-tRNA to the ribosome; Region: SelB; cd04171 441771008327 G1 box; other site 441771008328 putative GEF interaction site [polypeptide binding]; other site 441771008329 GTP/Mg2+ binding site [chemical binding]; other site 441771008330 Switch I region; other site 441771008331 G2 box; other site 441771008332 G3 box; other site 441771008333 Switch II region; other site 441771008334 G4 box; other site 441771008335 G5 box; other site 441771008336 selB_II: this subfamily represents the domain of elongation factor SelB, homologous to domain II of EF-Tu. SelB may function by replacing EF-Tu. In prokaryotes, the incorporation of selenocysteine as the 21st amino acid, encoded by TGA, requires several...; Region: selB_II; cd03696 441771008337 This family represents the domain of elongation factor SelB, homologous to domain III of EF-Tu. SelB may function by replacing EF-Tu. In prokaryotes, the incorporation of selenocysteine as the 21st amino acid, encoded by TGA, requires several elements:...; Region: selB_III; cd04094 441771008338 Elongation factor SelB, winged helix; Region: SelB-wing_2; pfam09106 441771008339 Elongation factor SelB, winged helix; Region: SelB-wing_3; pfam09107 441771008340 seryl-tRNA(sec) selenium transferase; Region: selA; TIGR00474 441771008341 Selenocysteine synthase N terminal; Region: Se-cys_synth_N; pfam12390 441771008342 L-seryl-tRNA selenium transferase; Region: SelA; pfam03841 441771008343 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 441771008344 catalytic residue [active] 441771008345 selenophosphate synthetase; Provisional; Region: PRK00943 441771008346 Selenophosphate synthetase (SelD) catalyzes the conversion of selenium to selenophosphate which is required by a number of bacterial, archaeal and eukaryotic organisms for synthesis of Secys-tRNA, the precursor of selenocysteine in selenoenzymes. The...; Region: SelD; cd02195 441771008347 dimerization interface [polypeptide binding]; other site 441771008348 putative ATP binding site [chemical binding]; other site 441771008349 SLBB domain; Region: SLBB; pfam10531 441771008350 comEA protein; Region: comE; TIGR01259 441771008351 Helix-hairpin-helix motif; Region: HHH_3; pfam12836 441771008352 D-alanyl-D-alanine carboxypeptidase [Cell envelope biogenesis, outer membrane]; Region: DacC; COG1686 441771008353 Beta-lactamase enzyme family; Region: Beta-lactamase2; cl19191 441771008354 Penicillin-binding protein 5, C-terminal domain; Region: PBP5_C; smart00936 441771008355 Pseudouridylate synthases, 23S RNA-specific [Translation, ribosomal structure and biogenesis]; Region: RluA; COG0564 441771008356 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 441771008357 RNA binding surface [nucleotide binding]; other site 441771008358 Pseudouridine synthase, RsuA/RluD family; Region: PseudoU_synth_RluCD_like; cd02869 441771008359 active site 441771008360 YjgF, YER057c, and UK114 belong to a large family of proteins present in bacteria, archaea, and eukaryotes with no definitive function. The conserved domain is similar in structure to chorismate mutase but there is no sequence similarity and no...; Region: YjgF_YER057c_UK114_family; cd00448 441771008361 homotrimer interaction site [polypeptide binding]; other site 441771008362 putative active site [active] 441771008363 Transcriptional regulator [Transcription]; Region: LytR; COG1316 441771008364 LytR cell envelope-related transcriptional attenuator; Region: LytR_C; pfam13399 441771008365 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 441771008366 Zn2+ binding site [ion binding]; other site 441771008367 Mg2+ binding site [ion binding]; other site 441771008368 Nicotinamide/nicotinate mononucleotide adenylyltransferase; Region: NMNAT; cd02165 441771008369 active site 441771008370 (T/H)XGH motif; other site 441771008371 Predicted RNA-binding protein containing KH domain, possibly ribosomal protein [Translation, ribosomal structure and biogenesis]; Region: COG1534 441771008372 GTPase CgtA; Reviewed; Region: obgE; PRK12297 441771008373 GTP1/OBG; Region: GTP1_OBG; pfam01018 441771008374 Obg GTPase; Region: Obg; cd01898 441771008375 G1 box; other site 441771008376 GTP/Mg2+ binding site [chemical binding]; other site 441771008377 Switch I region; other site 441771008378 G2 box; other site 441771008379 G3 box; other site 441771008380 Switch II region; other site 441771008381 G4 box; other site 441771008382 G5 box; other site 441771008383 Domain of unknown function (DUF1967); Region: DUF1967; pfam09269 441771008384 50S ribosomal protein L27; Validated; Region: rpmA; PRK05435 441771008385 hypothetical protein; Provisional; Region: PRK14553 441771008386 50S ribosomal protein L21; Validated; Region: rplU; PRK05573 441771008387 Ribonucleases G and E [Translation, ribosomal structure and biogenesis]; Region: CafA; COG1530 441771008388 S1_RNase_E: RNase E and RNase G, S1-like RNA-binding domain. RNase E is an essential endoribonuclease in the processing and degradation of RNA. In addition to its role in mRNA degradation, RNase E has also been implicated in the processing of rRNA, and...; Region: S1_RNase_E; cd04453 441771008389 homodimer interface [polypeptide binding]; other site 441771008390 oligonucleotide binding site [chemical binding]; other site 441771008391 Ribonuclease E/G family; Region: RNase_E_G; pfam10150 441771008392 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG5011 441771008393 radical SAM-linked protein; Region: sam_1_link_chp; TIGR03936 441771008394 radical SAM family uncharacterized protein; Region: rSAM_fuse_unch; TIGR03960 441771008395 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 441771008396 FeS/SAM binding site; other site 441771008397 Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl18945 441771008398 SpoIVFB Site-2 protease (S2P), a zinc metalloprotease (MEROPS family M50B), regulates intramembrane proteolysis (RIP), and is involved in the pro-sigmaK pathway of bacterial spore formation. SpoIVFB (sporulation protein, stage IV cell wall formation, F...; Region: S2P-M50_SpoIVFB; cd06161 441771008399 Peptidase family M50; Region: Peptidase_M50; pfam02163 441771008400 active site 441771008401 putative substrate binding region [chemical binding]; other site 441771008402 Membrane proteins related to metalloendopeptidases [Cell envelope biogenesis, outer membrane]; Region: NlpD; COG0739 441771008403 Peptidase family M23; Region: Peptidase_M23; pfam01551 441771008404 rod shape-determining protein RodA; Region: rodA_shape; TIGR02210 441771008405 cell division topological specificity factor MinE; Provisional; Region: PRK13987 441771008406 septum site-determining protein MinD; Region: minD_bact; TIGR01968 441771008407 Bacterial cell division requires the formation of a septum at mid-cell. The site is determined by the min operon products MinC, MinD and MinE. MinC is a nonspecific inhibitor of the septum protein FtsZ. MinE is the supressor of MinC. MinD plays a pivotal...; Region: MinD; cd02036 441771008408 P-loop; other site 441771008409 ADP binding residues [chemical binding]; other site 441771008410 Switch I; other site 441771008411 Switch II; other site 441771008412 septum formation inhibitor; Reviewed; Region: minC; PRK00513 441771008413 Septum formation inhibitor MinC, C-terminal domain; Region: MinC_C; pfam03775 441771008414 penicillin-binding protein 2; Region: pbp2_mrdA; TIGR03423 441771008415 Penicillin-binding Protein dimerization domain; Region: PBP_dimer; pfam03717 441771008416 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; cl17760 441771008417 rod shape-determining protein MreD; Region: shape_MreD; TIGR03426 441771008418 rod shape-determining protein MreC; Provisional; Region: PRK13922 441771008419 rod shape-determining protein MreB; Provisional; Region: PRK13927 441771008420 MreB and similar proteins; Region: MreB_like; cd10225 441771008421 nucleotide binding site [chemical binding]; other site 441771008422 Mg binding site [ion binding]; other site 441771008423 putative protofilament interaction site [polypeptide binding]; other site 441771008424 RodZ interaction site [polypeptide binding]; other site 441771008425 hypothetical protein; Reviewed; Region: PRK00024 441771008426 endonuclease III; includes endonuclease III (DNA-(apurinic or apyrimidinic site) lyase), alkylbase DNA glycosidases (Alka-family) and other DNA glycosidases; Region: ENDO3c; cl19066 441771008427 helix-hairpin-helix signature motif; other site 441771008428 Mov34/MPN/PAD-1 family; Region: MPN_DUF2466; cd08071 441771008429 MPN+ (JAMM) motif; other site 441771008430 Zinc-binding site [ion binding]; other site 441771008431 Nucleotide binding protein Maf. Maf has been implicated in inhibition of septum formation in eukaryotes, bacteria and archaea, but homologs in B.subtilis and S.cerevisiae are nonessential for cell division. Maf has been predicted to be a nucleotide- or...; Region: Maf; cd00555 441771008432 active site 441771008433 dimer interface [polypeptide binding]; other site 441771008434 Domain of unknown function (DUF4321); Region: DUF4321; pfam14209 441771008435 Predicted GTPase [General function prediction only]; Region: ThdF; COG0486 441771008436 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl17182 441771008437 Predicted epimerase, PhzC/PhzF homolog [General function prediction only]; Region: COG0384 441771008438 Diaminopimelate epimerase; Region: DAP_epimerase; cl19724 441771008439 hypothetical protein; Provisional; Region: PRK04435 441771008440 C-terminal ACT domain of a small (; 147 a.a.) putative phenylalanine biosynthetic pathway protein described in Bacillus subtilis (BS) PheB (PheB-BS) and related domains; Region: ACT_PheB-BS; cd04888 441771008441 Soluble lytic murein transglycosylase and related regulatory proteins (some contain LysM/invasin domains) [Cell envelope biogenesis, outer membrane]; Region: MltE; COG0741 441771008442 Lytic Transglycosylase (LT) and Goose Egg White Lysozyme (GEWL) domain. Members include the soluble and insoluble membrane-bound LTs in bacteria, the LTs in bacteriophage lambda, as well as, the eukaryotic "goose-type" lysozymes (GEWL). LTs...; Region: LT_GEWL; cd00254 441771008443 N-acetyl-D-glucosamine binding site [chemical binding]; other site 441771008444 catalytic residue [active] 441771008445 Dephospho-coenzyme A kinase (DPCK, EC 2.7.1.24) catalyzes the phosphorylation of dephosphocoenzyme A (dCoA) to yield CoA, which is the final step in CoA biosynthesis; Region: DPCK; cd02022 441771008446 Dephospho-CoA kinase [Coenzyme metabolism]; Region: CoaE; COG0237 441771008447 CoA-binding site [chemical binding]; other site 441771008448 ATP-binding [chemical binding]; other site 441771008449 DNA polymerase I; Provisional; Region: PRK05755 441771008450 PIN domain of the 5'-3' exonuclease of Taq DNA polymerase I and homologs; Region: PIN_53EXO; cd09859 441771008451 active site 441771008452 metal binding site 1 [ion binding]; metal-binding site 441771008453 putative 5' ssDNA interaction site; other site 441771008454 metal binding site 3; metal-binding site 441771008455 metal binding site 2 [ion binding]; metal-binding site 441771008456 H3TH domain of the 5'-3' exonuclease of Taq DNA polymerase I and homologs; Region: H3TH_53EXO; cd09898 441771008457 putative DNA binding site [nucleotide binding]; other site 441771008458 putative metal binding site [ion binding]; other site 441771008459 inactive DEDDy 3'-5' exonuclease domain of Bacillus stearothermophilus DNA polymerase I and similar family-A DNA polymerases; Region: DNA_polA_I_Bacillus_like_exo; cd06140 441771008460 Polymerase I functions primarily to fill DNA gaps that arise during DNA repair, recombination and replication; Region: DNA_pol_A_pol_I_C; cd08637 441771008461 active site 441771008462 DNA binding site [nucleotide binding] 441771008463 catalytic site [active] 441771008464 Chorismase synthase, the enzyme catalyzing the final step of the shikimate pathway; Region: Chorismate_synthase; cd07304 441771008465 Tetramer interface [polypeptide binding]; other site 441771008466 active site 441771008467 FMN-binding site [chemical binding]; other site 441771008468 N-acetylmuramoyl-L-alanine amidase or MurNAc-LAA (also known as peptidoglycan aminohydrolase, NAMLA amidase, NAMLAA, Amidase 3, and peptidoglycan amidase; EC 3.5.1.28) is an autolysin that hydrolyzes the amide bond between N-acetylmuramoyl and L-amino...; Region: MurNAc-LAA; cd02696 441771008469 active site 441771008470 metal binding site [ion binding]; metal-binding site 441771008471 Bacterial SH3 domain; Region: SH3_3; pfam08239 441771008472 Haemolysin XhlA; Region: XhlA; pfam10779 441771008473 Concanavalin A-like lectin/glucanases superfamily; Region: Laminin_G_3; pfam13385 441771008474 F5/8 type C domain; Region: F5_F8_type_C; pfam00754 441771008475 Caspase domain; Region: Peptidase_C14; pfam00656 441771008476 Apolipophorin-III and similar insect proteins; Region: ApoLp-III_like; cl19113 441771008477 Phage-related protein [Function unknown]; Region: COG5412 441771008478 hypothetical protein; Validated; Region: PRK08116 441771008479 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 441771008480 Walker A motif; other site 441771008481 ATP binding site [chemical binding]; other site 441771008482 Walker B motif; other site 441771008483 arginine finger; other site 441771008484 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 441771008485 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 441771008486 non-specific DNA binding site [nucleotide binding]; other site 441771008487 salt bridge; other site 441771008488 sequence-specific DNA binding site [nucleotide binding]; other site 441771008489 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 441771008490 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 441771008491 non-specific DNA binding site [nucleotide binding]; other site 441771008492 salt bridge; other site 441771008493 sequence-specific DNA binding site [nucleotide binding]; other site 441771008494 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 441771008495 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 441771008496 non-specific DNA binding site [nucleotide binding]; other site 441771008497 salt bridge; other site 441771008498 sequence-specific DNA binding site [nucleotide binding]; other site 441771008499 Predicted membrane protein involved in D-alanine export [Cell envelope biogenesis, outer membrane]; Region: DltB; COG1696 441771008500 Small, acid-soluble spore proteins, alpha/beta type; Region: SASP; pfam00269 441771008501 Positive regulator of sigma(E), RseC/MucC; Region: RseC_MucC; pfam04246 441771008502 aspartyl-tRNA synthetase; Validated; Region: aspS; PRK00476 441771008503 EcAspRS_like_N: N-terminal, anticodon recognition domain of the type found in Escherichia coli aspartyl-tRNA synthetase (AspRS), the human mitochondrial (mt) AspRS-2, the discriminating (D) Thermus thermophilus AspRS-1, and the nondiscriminating (ND)...; Region: EcAspRS_like_N; cd04317 441771008504 dimer interface [polypeptide binding]; other site 441771008505 anticodon binding site; other site 441771008506 Asp tRNA synthetase (aspRS) class II core domain. Class II assignment is based upon its structure and the presence of three characteristic sequence motifs. AspRS is a homodimer, which attaches a specific amino acid to the 3' OH group of ribose of...; Region: AspRS_core; cd00777 441771008507 homodimer interface [polypeptide binding]; other site 441771008508 motif 1; other site 441771008509 active site 441771008510 motif 2; other site 441771008511 GAD domain; Region: GAD; pfam02938 441771008512 motif 3; other site 441771008513 histidyl-tRNA synthetase; Reviewed; Region: hisS; PRK00037 441771008514 Class II Histidinyl-tRNA synthetase (HisRS)-like catalytic core domain. HisRS is a homodimer. It is responsible for the attachment of histidine to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for...; Region: HisRS-like_core; cd00773 441771008515 dimer interface [polypeptide binding]; other site 441771008516 motif 1; other site 441771008517 active site 441771008518 motif 2; other site 441771008519 motif 3; other site 441771008520 HisRS Histidyl-anticodon binding domain. HisRS belongs to class II aminoacyl-tRNA synthetases (aaRS). This alignment contains the anticodon binding domain, which is responsible for specificity in tRNA-binding, so that the activated amino acid is...; Region: HisRS_anticodon; cd00859 441771008521 anticodon binding site; other site 441771008522 coproporphyrinogen III oxidase; Provisional; Region: PRK08207 441771008523 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 441771008524 FeS/SAM binding site; other site 441771008525 Metallo-beta-lactamase superfamily; Region: Lactamase_B; smart00849 441771008526 D-Tyrosyl-tRNAtyr deacylases; a class of tRNA-dependent hydrolases which are capable of hydrolyzing the ester bond of D-Tyrosyl-tRNA reducing the level of cellular D-Tyrosine while recycling the peptidyl-tRNA; found in bacteria and in eukaryotes but not...; Region: Dtyr_deacylase; cd00563 441771008527 putative active site [active] 441771008528 dimerization interface [polypeptide binding]; other site 441771008529 putative tRNAtyr binding site [nucleotide binding]; other site 441771008530 Guanosine polyphosphate pyrophosphohydrolases/synthetases [Signal transduction mechanisms / Transcription]; Region: SpoT; COG0317 441771008531 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 441771008532 Zn2+ binding site [ion binding]; other site 441771008533 Mg2+ binding site [ion binding]; other site 441771008534 Nucleotidyltransferase (NT) domain of RelA- and SpoT-like ppGpp synthetases and hydrolases; Region: NT_Rel-Spo_like; cd05399 441771008535 synthetase active site [active] 441771008536 NTP binding site [chemical binding]; other site 441771008537 metal binding site [ion binding]; metal-binding site 441771008538 TGS_RelA_SpoT: The RelA (SpoT) protein, also referred to as ppGpp hydrolase/synthetase, is a ribosome-associated protein that is activated during amino acid starvation and thought to mediate the stringent response. RelA contains a TGS domain, named after...; Region: TGS_RelA_SpoT; cd01668 441771008539 ACT domain found C-terminal of the RelA/SpoT domains; Region: ACT_RelA-SpoT; cd04876 441771008540 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 441771008541 active site 441771008542 DHH family; Region: DHH; pfam01368 441771008543 preprotein translocase subunit SecF; Reviewed; Region: secF; PRK13022 441771008544 SecD/SecF GG Motif; Region: Sec_GG; pfam07549 441771008545 Protein export membrane protein; Region: SecD_SecF; pfam02355 441771008546 preprotein translocase subunit SecD; Reviewed; Region: secD; PRK05812 441771008547 protein-export membrane protein, SecD/SecF family; Region: 2A0604s01; TIGR00916 441771008548 SCIFF radical SAM maturase; Region: rSAM_six_Cys; TIGR03974 441771008549 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 441771008550 FeS/SAM binding site; other site 441771008551 radical SAM additional 4Fe4S-binding SPASM domain; Region: rSAM_more_4Fe4S; TIGR04085 441771008552 Protein of unknown function (DUF4001); Region: DUF4001; pfam13165 441771008553 Protein of unknown function (DUF3792); Region: DUF3792; pfam12670 441771008554 preprotein translocase subunit YajC; Validated; Region: yajC; PRK05585 441771008555 queuine tRNA-ribosyltransferase; Provisional; Region: tgt; PRK00112 441771008556 Queuine/archaeosine tRNA-ribosyltransferase [Translation, ribosomal structure and biogenesis]; Region: Tgt; COG0343 441771008557 S-adenosylmethionine:tRNA ribosyltransferase-isomerase; Provisional; Region: queA; PRK00147 441771008558 Holliday junction DNA helicase RuvB; Reviewed; Region: ruvB; PRK00080 441771008559 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 441771008560 Walker A motif; other site 441771008561 ATP binding site [chemical binding]; other site 441771008562 Walker B motif; other site 441771008563 arginine finger; other site 441771008564 Holliday junction DNA helicase ruvB C-terminus; Region: RuvB_C; pfam05491 441771008565 Holliday junction DNA helicase RuvA; Reviewed; Region: ruvA; PRK00116 441771008566 RuvA N terminal domain; Region: RuvA_N; pfam01330 441771008567 Helix-hairpin-helix domain; Region: HHH_5; pfam14520 441771008568 RuvA, C-terminal domain; Region: RuvA_C; pfam07499 441771008569 hypothetical protein; Validated; Region: PRK00110 441771008570 Uncharacterized conserved protein [Function unknown]; Region: COG1739 441771008571 Uncharacterized protein family UPF0029; Region: UPF0029; pfam01205 441771008572 Domain of unknown function (DUF1949); Region: DUF1949; pfam09186 441771008573 Helix-turn-helix domain; Region: HTH_40; pfam14493 441771008574 HEAT repeats; Region: HEAT_2; pfam13646 441771008575 HEAT repeats; Region: HEAT_2; pfam13646 441771008576 HEAT-like repeat; Region: HEAT_EZ; pfam13513 441771008577 Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain (MocR family) and their eukaryotic orthologs [Transcription / Amino acid transport and metabolism]; Region: ARO8; COG1167 441771008578 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 441771008579 DNA-binding site [nucleotide binding]; DNA binding site 441771008580 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 441771008581 pyridoxal 5'-phosphate binding site [chemical binding]; other site 441771008582 homodimer interface [polypeptide binding]; other site 441771008583 catalytic residue [active] 441771008584 Nucleotidyltransferase (NT) domain of Staphylococcus aureus kanamycin nucleotidyltransferase, and similar proteins; Region: NT_KNTase_like; cd05403 441771008585 active site 441771008586 NTP binding site [chemical binding]; other site 441771008587 metal binding triad [ion binding]; metal-binding site 441771008588 antibiotic binding site [chemical binding]; other site 441771008589 Rubredoxin [Energy production and conversion]; Region: COG1773 441771008590 Rubredoxin; nonheme iron binding domains containing a [Fe(SCys)4] center. Rubredoxins are small nonheme iron proteins. The iron atom is coordinated by four cysteine residues (Fe(S-Cys)4), but iron can also be replaced by cobalt, nickel or zinc. They are...; Region: rubredoxin; cd00730 441771008591 iron binding site [ion binding]; other site 441771008592 GTP-binding protein HflX; Region: GTP_HflX; TIGR03156 441771008593 GTP-binding GTPase N-terminal; Region: GTP-bdg_N; pfam13167 441771008594 HflX GTPase family; Region: HflX; cd01878 441771008595 G1 box; other site 441771008596 GTP/Mg2+ binding site [chemical binding]; other site 441771008597 Switch I region; other site 441771008598 G2 box; other site 441771008599 G3 box; other site 441771008600 Switch II region; other site 441771008601 G4 box; other site 441771008602 G5 box; other site 441771008603 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 441771008604 active site 441771008605 Sporulation protein YunB (Spo_YunB); Region: Spore_YunB; cl09783 441771008606 Transglycosylase; Region: Transgly; pfam00912 441771008607 penicillin-binding protein, 1A family; Region: PBP_1a_fam; TIGR02074 441771008608 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; cl17760 441771008609 SpoVA protein; Region: SpoVA; cl04298 441771008610 stage V sporulation protein AD; Validated; Region: PRK08304 441771008611 stage V sporulation protein AD; Region: spore_V_AD; TIGR02845 441771008612 SpoVA protein; Region: SpoVA; cl04298 441771008613 sporulation sigma factor SigF; Validated; Region: PRK05572 441771008614 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 441771008615 Sigma-70 region 3; Region: Sigma70_r3; pfam04539 441771008616 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 441771008617 DNA binding residues [nucleotide binding] 441771008618 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 441771008619 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 441771008620 ATP binding site [chemical binding]; other site 441771008621 Mg2+ binding site [ion binding]; other site 441771008622 G-X-G motif; other site 441771008623 Sulphate Transporter and Anti-Sigma factor antagonist) domain of anti-anti-sigma factors, key regulators of anti-sigma factors by phosphorylation; Region: STAS_anti-anti-sigma_factors; cd07043 441771008624 anti sigma factor interaction site; other site 441771008625 regulatory phosphorylation site [posttranslational modification]; other site 441771008626 type II restriction m6 adenine DNA methyltransferase, Alw26I/Eco31I/Esp3I family; Region: met_A_Alw26; TIGR02987 441771008627 TaqI-like C-terminal specificity domain; Region: TaqI_C; pfam12950 441771008628 Catalytic NodB homology domain of Bacillus subtilis polysaccharide deacetylase PdaA, and its bacterial homologs; Region: CE4_BsPdaA_like; cd10948 441771008629 delta-lactam-biosynthetic de-N-acetylase; Region: spore_pdaA; TIGR02884 441771008630 NodB motif; other site 441771008631 active site 441771008632 catalytic site [active] 441771008633 Cd binding site [ion binding]; other site 441771008634 The glycosyltransferase WecG/TagA superfamily contains Escherichia coli WecG, Bacillus subtilis TagA and related proteins. E. coli WecG is believed to be a UDP-N-acetyl-D-mannosaminuronic acid transferase, and is involved in enterobacterial common...; Region: Glyco_transf_WecG_TagA; cd06533 441771008635 Bacterial sugar transferase; Region: Bac_transf; pfam02397 441771008636 Membrane protein involved in the export of O-antigen and teichoic acid [General function prediction only]; Region: RfbX; COG2244 441771008637 Multidrug and toxic compound extrusion family and similar proteins; Region: MATE_like; cl09326 441771008638 Polysaccharide biosynthesis C-terminal domain; Region: Polysacc_synt_C; pfam14667 441771008639 integral membrane protein MviN; Region: mviN; TIGR01695 441771008640 MurJ/MviN, a subfamily of the multidrug and toxic compound extrusion (MATE)-like proteins; Region: MATE_MurJ_like; cd13123 441771008641 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 441771008642 This family is most closely related to the GT1 family of glycosyltransferases and named after YqgM in Bacillus licheniformis about which little is known. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to...; Region: GT1_YqgM_like; cd03801 441771008643 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 441771008644 This family is most closely related to the GT1 family of glycosyltransferases. wlbH in Bordetella parapertussis has been shown to be required for the biosynthesis of a trisaccharide that, when attached to the B. pertussis lipopolysaccharide (LPS) core; Region: GT1_wlbH_like; cd03798 441771008645 O-antigen ligase like membrane protein; Region: O-antigen_lig; cl04850 441771008646 Lipid A core - O-antigen ligase and related enzymes [Cell envelope biogenesis, outer membrane]; Region: RfaL; COG3307 441771008647 This family is most closely related to the GT1 family of glycosyltransferases. wbuB in E. coli is involved in the biosynthesis of the O26 O-antigen. It has been proposed to function as an N-acetyl-L-fucosamine (L-FucNAc) transferase; Region: GT1_wbuB_like; cd03794 441771008648 putative glycosyl transferase; Provisional; Region: PRK10307 441771008649 Bacterial members of the UDP-N-Acetylglucosamine (GlcNAc) 2-Epimerase family are known to catalyze the reversible interconversion of UDP-GlcNAc and UDP-N-acetylmannosamine (UDP-ManNAc). The enzyme serves to produce an activated form of ManNAc residues; Region: GT1_UDP-GlcNAc_2-Epimerase; cd03786 441771008650 active site 441771008651 UDP-N-acetylglucosamine 2-epimerase; Region: Epimerase_2; pfam02350 441771008652 homodimer interface [polypeptide binding]; other site 441771008653 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 441771008654 This family is most closely related to the GT1 family of glycosyltransferases. wlbH in Bordetella parapertussis has been shown to be required for the biosynthesis of a trisaccharide that, when attached to the B. pertussis lipopolysaccharide (LPS) core; Region: GT1_wlbH_like; cd03798 441771008655 beta-1,6-galactofuranosyltransferase; Provisional; Region: PRK09814 441771008656 Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013 441771008657 Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 residue sequence motifs present in many proteins that participate in protein-protein interactions and have different functions and cellular locations. LRRs correspond...; Region: LRR_RI; cd00116 441771008658 Leucine rich repeat; Region: LRR_8; pfam13855 441771008659 Leucine-rich repeats; other site 441771008660 Substrate binding site [chemical binding]; other site 441771008661 Leucine rich repeat; Region: LRR_8; pfam13855 441771008662 Leucine Rich repeats (2 copies); Region: LRR_4; pfam12799 441771008663 Leucine Rich repeats (2 copies); Region: LRR_4; pfam12799 441771008664 Multidrug and toxic compound extrusion family and similar proteins; Region: MATE_like; cl09326 441771008665 Na+-driven multidrug efflux pump [Defense mechanisms]; Region: NorM; COG0534 441771008666 Left-handed parallel beta-Helix (LbetaH or LbH) domain: The alignment contains 5 turns, each containing three imperfect tandem repeats of a hexapeptide repeat motif (X-[STAV]-X-[LIV]-[GAED]-X). Proteins containing hexapeptide repeats are often enzymes...; Region: LbetaH; cl00160 441771008667 putative trimer interface [polypeptide binding]; other site 441771008668 putative CoA binding site [chemical binding]; other site 441771008669 WcxM-like, Left-handed parallel beta-Helix (LbH) N-terminal domain: This group is composed of Xanthomonas campestris WcxM and proteins with similarity to the WcxM N-terminal domain. WcxM is thought to be bifunctional, catalyzing both the isomerization...; Region: LbH_WxcM_N_like; cd03358 441771008670 putative trimer interface [polypeptide binding]; other site 441771008671 putative active site [active] 441771008672 putative substrate binding site [chemical binding]; other site 441771008673 putative CoA binding site [chemical binding]; other site 441771008674 Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673 441771008675 Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408 441771008676 Oxidoreductase family, C-terminal alpha/beta domain; Region: GFO_IDH_MocA_C; pfam02894 441771008677 UDP-N-acetyl-D-mannosaminuronate dehydrogenase [Cell envelope biogenesis, outer membrane]; Region: WecC; COG0677 441771008678 UDP-glucose/GDP-mannose dehydrogenase family, NAD binding domain; Region: UDPG_MGDP_dh_N; pfam03721 441771008679 UDP-glucose/GDP-mannose dehydrogenase family, central domain; Region: UDPG_MGDP_dh; pfam00984 441771008680 UDP binding domain; Region: UDPG_MGDP_dh_C; smart00984 441771008681 Predicted nucleoside-diphosphate sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: COG1086 441771008682 CoA binding domain; Region: CoA_binding; cl17356 441771008683 UDP-Glcnac (UDP-linked N-acetylglucosamine) inverting 4,6-dehydratase, extended (e) SDRs; Region: UDP_invert_4-6DH_SDR_e; cd05237 441771008684 NAD(P) binding site [chemical binding]; other site 441771008685 homodimer interface [polypeptide binding]; other site 441771008686 substrate binding site [chemical binding]; other site 441771008687 active site 441771008688 Mannosyl-glycoprotein endo-beta-N-acetylglucosaminidase; Region: Glucosaminidase; cl17361 441771008689 triple tyrosine motif-containing protein; Provisional; Region: PRK14081 441771008690 Y_Y_Y domain; Region: Y_Y_Y; pfam07495 441771008691 Y_Y_Y domain; Region: Y_Y_Y; pfam07495 441771008692 Y_Y_Y domain; Region: Y_Y_Y; pfam07495 441771008693 Y_Y_Y domain; Region: Y_Y_Y; pfam07495 441771008694 N-acetylmuramoyl-L-alanine amidase [Cell envelope biogenesis, outer membrane]; Region: AmiC; COG0860 441771008695 N-acetylmuramoyl-L-alanine amidase or MurNAc-LAA (also known as peptidoglycan aminohydrolase, NAMLA amidase, NAMLAA, Amidase 3, and peptidoglycan amidase; EC 3.5.1.28) is an autolysin that hydrolyzes the amide bond between N-acetylmuramoyl and L-amino...; Region: MurNAc-LAA; cd02696 441771008696 active site 441771008697 metal binding site [ion binding]; metal-binding site 441771008698 triple tyrosine motif-containing protein; Provisional; Region: PRK14081 441771008699 N-acetylmuramoyl-L-alanine amidase [Cell envelope biogenesis, outer membrane]; Region: AmiC; COG0860 441771008700 N-acetylmuramoyl-L-alanine amidase or MurNAc-LAA (also known as peptidoglycan aminohydrolase, NAMLA amidase, NAMLAA, Amidase 3, and peptidoglycan amidase; EC 3.5.1.28) is an autolysin that hydrolyzes the amide bond between N-acetylmuramoyl and L-amino...; Region: MurNAc-LAA; cd02696 441771008701 active site 441771008702 metal binding site [ion binding]; metal-binding site 441771008703 triple tyrosine motif-containing protein; Provisional; Region: PRK14081 441771008704 Beta- N-acetylglucosaminidase [Carbohydrate transport and metabolism]; Region: LytD; COG4193 441771008705 Mannosyl-glycoprotein endo-beta-N-acetylglucosaminidase; Region: Glucosaminidase; cl17361 441771008706 Prokaryotic UGPase catalyses the synthesis of UDP-glucose; Region: UGPase_prokaryotic; cd02541 441771008707 dTDP-glucose pyrophosphorylase [Cell envelope biogenesis, outer membrane]; Region: RfbA; COG1209 441771008708 active site 441771008709 tetramer interface; other site 441771008710 Tetratricopeptide repeat; Region: TPR_12; pfam13424 441771008711 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 441771008712 binding surface 441771008713 TPR motif; other site 441771008714 phosphoglucomutase-2-like protein; Provisional; Region: PTZ00150 441771008715 This CD includes PGM2 (phosphoglucomutase 2) and PGM2L1 (phosphoglucomutase 2-like 1). The mammalian PGM2 is thought to be a phosphopentomutase that catalyzes the conversion of the nucleoside breakdown products, ribose-1-phosphate and...; Region: PGM2; cd05799 441771008716 active site 441771008717 substrate binding site [chemical binding]; other site 441771008718 metal binding site [ion binding]; metal-binding site 441771008719 50S ribosomal protein L25/general stress protein Ctc; Reviewed; Region: PRK05618 441771008720 Ribosomal L25/TL5/CTC N-terminal 5S rRNA binding domain; Region: Ribosomal_L25_TL5_CTC; cd00495 441771008721 5S rRNA interface [nucleotide binding]; other site 441771008722 CTC domain interface [polypeptide binding]; other site 441771008723 L16 interface [polypeptide binding]; other site 441771008724 Ribosomal protein TL5, C-terminal domain; Region: Ribosomal_TL5_C; pfam14693 441771008725 Arginine/lysine/ornithine decarboxylases [Amino acid transport and metabolism]; Region: LdcC; COG1982 441771008726 Ornithine decarboxylase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD corresponds to ornithine decarboxylase (ODC), arginine decarboxylase (ADC) and lysine...; Region: Orn_deC_like; cd00615 441771008727 homodimer interface [polypeptide binding]; other site 441771008728 pyridoxal 5'-phosphate binding site [chemical binding]; other site 441771008729 catalytic residue [active] 441771008730 Orn/Lys/Arg decarboxylase, C-terminal domain; Region: OKR_DC_1_C; pfam03711 441771008731 Phosphate acetyl/butaryl transferase; Region: PTA_PTB; cl17212 441771008732 Family of homologous FMN-dependent alpha-hydroxyacid oxidizing enzymes. This family occurs in both prokaryotes and eukaryotes. Members of this family include flavocytochrome b2 (FCB2), glycolate oxidase (GOX), lactate monooxygenase (LMO), mandelate...; Region: alpha_hydroxyacid_oxid_FMN; cd02809 441771008733 active site 441771008734 substrate binding site [chemical binding]; other site 441771008735 FMN-dependent dehydrogenase; Region: FMN_dh; pfam01070 441771008736 FMN binding site [chemical binding]; other site 441771008737 putative catalytic residues [active] 441771008738 Uncharacterized conserved protein [Function unknown]; Region: COG1683 441771008739 recombination and DNA strand exchange inhibitor protein; Reviewed; Region: PRK00409 441771008740 MutS domain III; Region: MutS_III; pfam05192 441771008741 ATP-binding cassette domain of MutS2; Region: ABC_MutS2; cd03280 441771008742 Walker A/P-loop; other site 441771008743 ATP binding site [chemical binding]; other site 441771008744 Q-loop/lid; other site 441771008745 ABC transporter signature motif; other site 441771008746 Walker B; other site 441771008747 D-loop; other site 441771008748 H-loop/switch region; other site 441771008749 Smr domain; Region: Smr; pfam01713 441771008750 Collagenase and related proteases [Posttranslational modification, protein turnover, chaperones]; Region: COG0826 441771008751 Collagenase; Region: DUF3656; pfam12392 441771008752 Peptidase family U32; Region: Peptidase_U32; cl03113 441771008753 CRISPR/Cas system-associated protein Cas9; Region: Csn1; cd09643 441771008754 Protein of unknown function (DUF342); Region: DUF342; cl19219 441771008755 Cell division protein ZapA; Region: ZapA; pfam05164 441771008756 phenylalanyl-tRNA synthetase subunit beta; Reviewed; Region: pheT; PRK00629 441771008757 tRNA-binding-domain-containing prokaryotic phenylalanly tRNA synthetase (PheRS) beta chain. PheRS aminoacylate phenylalanine transfer RNAs (tRNAphe). PheRSs belong structurally to class II aminoacyl tRNA synthetases (aaRSs) but, as they aminoacylate...; Region: tRNA_bind_bactPheRS; cd02796 441771008758 putative tRNA-binding site [nucleotide binding]; other site 441771008759 B3/4 domain; Region: B3_4; pfam03483 441771008760 tRNA synthetase B5 domain; Region: B5; smart00874 441771008761 Phenylalanyl-tRNA synthetase (PheRS) beta chain core domain. PheRS belongs to class II aminoacyl-tRNA synthetases (aaRS) based upon its structure. While class II aaRSs generally aminoacylate the 3'-OH ribose of the appropriate tRNA, PheRS is an...; Region: PheRS_beta_core; cd00769 441771008762 dimer interface [polypeptide binding]; other site 441771008763 motif 1; other site 441771008764 motif 3; other site 441771008765 motif 2; other site 441771008766 Ferredoxin-fold anticodon binding domain; Region: FDX-ACB; smart00896 441771008767 phenylalanyl-tRNA synthetase subunit alpha; Validated; Region: pheS; PRK00488 441771008768 Aminoacyl tRNA synthetase class II, N-terminal domain; Region: Phe_tRNA-synt_N; pfam02912 441771008769 Phenylalanyl-tRNA synthetase (PheRS) alpha chain catalytic core domain. PheRS belongs to class II aminoacyl-tRNA synthetases (aaRS) based upon its structure and the presence of three characteristic sequence motifs. This domain is primarily responsible...; Region: PheRS_alpha_core; cd00496 441771008770 dimer interface [polypeptide binding]; other site 441771008771 motif 1; other site 441771008772 active site 441771008773 motif 2; other site 441771008774 motif 3; other site 441771008775 rRNA methylases [Translation, ribosomal structure and biogenesis]; Region: SpoU; COG0566 441771008776 RNA 2'-O ribose methyltransferase substrate binding; Region: SpoU_sub_bind; smart00967 441771008777 SpoU rRNA Methylase family; Region: SpoU_methylase; pfam00588 441771008778 K+ transport systems, NAD-binding component [Inorganic ion transport and metabolism]; Region: TrkA; COG0569 441771008779 TrkA-N domain; Region: TrkA_N; pfam02254 441771008780 TrkA-C domain; Region: TrkA_C; pfam02080 441771008781 potassium uptake protein, TrkH family; Region: 2a38; TIGR00933 441771008782 Cation transport protein; Region: TrkH; cl17365 441771008783 Ribosomal protein L20; Region: Ribosomal_L20; cd07026 441771008784 23S rRNA binding site [nucleotide binding]; other site 441771008785 L21 binding site [polypeptide binding]; other site 441771008786 L13 binding site [polypeptide binding]; other site 441771008787 50S ribosomal protein L35; Reviewed; Region: rpmI; PRK00172 441771008788 translation initiation factor IF-3; Reviewed; Region: infC; PRK00028 441771008789 Translation initiation factor IF-3, N-terminal domain; Region: IF3_N; pfam05198 441771008790 Translation initiation factor IF-3, C-terminal domain; Region: IF3_C; pfam00707 441771008791 threonyl-tRNA synthetase; Reviewed; Region: thrS; PRK00413 441771008792 TGS _ThrRS_N: ThrRS (threonyl-tRNA Synthetase) is a class II tRNA synthetase that couples threonine to its cognate tRNA. In addition to its catalytic and anticodon-binding domains, ThrRS has an N-terminal TGS domain, named after the ThrRS, GTPase, and...; Region: TGS_ThrRS_N; cd01667 441771008793 Threonyl and Alanyl tRNA synthetase second additional domain; Region: tRNA_SAD; smart00863 441771008794 Threonyl-tRNA synthetase (ThrRS) class II core catalytic domain. ThrRS is a homodimer. It is responsible for the attachment of threonine to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for ATP-dependent...; Region: ThrRS_core; cd00771 441771008795 active site 441771008796 dimer interface [polypeptide binding]; other site 441771008797 motif 1; other site 441771008798 motif 2; other site 441771008799 motif 3; other site 441771008800 ThrRS Threonyl-anticodon binding domain. ThrRS belongs to class II aminoacyl-tRNA synthetases (aaRS). This alignment contains the anticodon binding domain, which is responsible for specificity in tRNA-binding, so that the activated amino acid is...; Region: ThrRS_anticodon; cd00860 441771008801 anticodon binding site; other site 441771008802 YtxC-like family; Region: YtxC; pfam08812 441771008803 ABC-type Na+ transport system, ATPase component [Energy production and conversion / Inorganic ion transport and metabolism]; Region: NatA; COG4555 441771008804 ATP-binding cassette domain of the drug resistance transporter and related proteins, subfamily A; Region: ABC_DR_subfamily_A; cd03230 441771008805 Walker A/P-loop; other site 441771008806 ATP binding site [chemical binding]; other site 441771008807 Q-loop/lid; other site 441771008808 ABC transporter signature motif; other site 441771008809 Walker B; other site 441771008810 D-loop; other site 441771008811 H-loop/switch region; other site 441771008812 Hsp33-like chaperonin; Reviewed; Region: hslO; PRK00114 441771008813 Heat shock protein 33 (Hsp33): Cytosolic protein that acts as a molecular chaperone under oxidative conditions. In normal (reducing) cytosolic conditions, four conserved Cys residues are coordinated by a Zn ion. Under oxidative stress (such as heat...; Region: Hsp33; cd00498 441771008814 dimerization interface [polypeptide binding]; other site 441771008815 domain crossover interface; other site 441771008816 redox-dependent activation switch; other site 441771008817 SAM-dependent methyltransferases [Secondary metabolites biosynthesis, transport, and catabolism / General function prediction only]; Region: SmtA; COG0500 441771008818 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 441771008819 S-adenosylmethionine binding site [chemical binding]; other site 441771008820 Small, acid-soluble spore proteins, alpha/beta type; Region: SASP; pfam00269 441771008821 oligopeptide ABC transporter ATP-binding protein OppF; Provisional; Region: PRK15079 441771008822 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 441771008823 Walker A/P-loop; other site 441771008824 ATP binding site [chemical binding]; other site 441771008825 Q-loop/lid; other site 441771008826 ABC transporter signature motif; other site 441771008827 Walker B; other site 441771008828 D-loop; other site 441771008829 H-loop/switch region; other site 441771008830 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097 441771008831 ABC-type dipeptide/oligopeptide/nickel transport system, ATPase component [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppD; COG0444 441771008832 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 441771008833 Walker A/P-loop; other site 441771008834 ATP binding site [chemical binding]; other site 441771008835 Q-loop/lid; other site 441771008836 ABC transporter signature motif; other site 441771008837 Walker B; other site 441771008838 D-loop; other site 441771008839 H-loop/switch region; other site 441771008840 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097 441771008841 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppC; COG1173 441771008842 N-terminal TM domain of oligopeptide transport permease C; Region: OppC_N; pfam12911 441771008843 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 441771008844 dimer interface [polypeptide binding]; other site 441771008845 conserved gate region; other site 441771008846 putative PBP binding loops; other site 441771008847 ABC-ATPase subunit interface; other site 441771008848 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppB; COG0601 441771008849 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 441771008850 dimer interface [polypeptide binding]; other site 441771008851 conserved gate region; other site 441771008852 putative PBP binding loops; other site 441771008853 ABC-ATPase subunit interface; other site 441771008854 ABC-type oligopeptide transport system, periplasmic component [Amino acid transport and metabolism]; Region: OppA; COG4166 441771008855 The substrate-binding component of an ABC-type oligopetide import system contains the type 2 periplasmic binding fold; Region: PBP2_OppA; cd08504 441771008856 peptide binding site [polypeptide binding]; other site 441771008857 aspartate-semialdehyde dehydrogenase; Provisional; Region: PRK14874 441771008858 Semialdehyde dehydrogenase, NAD binding domain; Region: Semialdhyde_dh; pfam01118 441771008859 Semialdehyde dehydrogenase, dimerization domain; Region: Semialdhyde_dhC; pfam02774 441771008860 Dihydrodipicolinate synthase (DHDPS); Region: DHDPS; cd00950 441771008861 dimer interface [polypeptide binding]; other site 441771008862 active site 441771008863 catalytic residue [active] 441771008864 dihydrodipicolinate reductase; Provisional; Region: PRK00048 441771008865 Dihydrodipicolinate reductase, N-terminus; Region: DapB_N; pfam01113 441771008866 Dihydrodipicolinate reductase, C-terminus; Region: DapB_C; pfam05173 441771008867 aminotransferase A; Validated; Region: PRK07683 441771008868 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 441771008869 pyridoxal 5'-phosphate binding site [chemical binding]; other site 441771008870 homodimer interface [polypeptide binding]; other site 441771008871 catalytic residue [active] 441771008872 Tetrahydrodipicolinate succinyltransferase N-terminal; Region: DapH_N; pfam08503 441771008873 2,3,4,5-tetrahydropyridine-2,6-dicarboxylate N-acetyltransferase; Region: DapD_Ac; TIGR03532 441771008874 2,3,4,5-tetrahydropyridine-2,6-dicarboxylate (THDP) N-succinyltransferase (also called THP succinyltransferase): THDP N-succinyltransferase catalyzes the conversion of tetrahydrodipicolinate and succinyl-CoA to N-succinyltetrahydrodipicolinate and CoA; Region: LbH_THP_succinylT; cd03350 441771008875 trimer interface [polypeptide binding]; other site 441771008876 active site 441771008877 substrate binding site [chemical binding]; other site 441771008878 CoA binding site [chemical binding]; other site 441771008879 single-stranded DNA-binding protein; Provisional; Region: PRK05813 441771008880 Replication protein A, class 2b aminoacyl-tRNA synthetases, and related proteins with oligonucleotide/oligosaccharide (OB) fold; Region: RPA_2b-aaRSs_OBF_like; cl09930 441771008881 SSB_OBF: A subfamily of OB folds similar to the OB fold of ssDNA-binding protein (SSB). SSBs bind with high affinity to ssDNA. They bind to and protect ssDNA intermediates during DNA metabolic pathways. All bacterial and eukaryotic SSBs studied to date...; Region: SSB_OBF; cd04496 441771008882 dimer interface [polypeptide binding]; other site 441771008883 ssDNA binding site [nucleotide binding]; other site 441771008884 tetramer (dimer of dimers) interface [polypeptide binding]; other site 441771008885 Predicted xylanase/chitin deacetylase [Carbohydrate transport and metabolism]; Region: CDA1; COG0726 441771008886 Catalytic NodB homology domain of rhizobial NodB-like proteins; Region: CE4_NodB_like_6s_7s; cd10917 441771008887 NodB motif; other site 441771008888 active site 441771008889 catalytic site [active] 441771008890 metal binding site [ion binding]; metal-binding site 441771008891 Domain of unknown function (DUF4364); Region: DUF4364; pfam14277 441771008892 Uncharacterized conserved protein [Function unknown]; Region: COG3391 441771008893 uncharacterized protein TIGR03905; Region: TIGR03905_4_Cys 441771008894 Folylpolyglutamate synthase [Coenzyme metabolism]; Region: FolC; COG0285 441771008895 Mur ligase middle domain; Region: Mur_ligase_M; pfam08245 441771008896 Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875 441771008897 valyl-tRNA synthetase; Reviewed; Region: valS; PRK05729 441771008898 catalytic core domain of valyl-tRNA synthetases; Region: ValRS_core; cd00817 441771008899 active site 441771008900 HIGH motif; other site 441771008901 Leucyl-tRNA synthetase, Domain 2; Region: tRNA-synt_1_2; pfam13603 441771008902 KMSKS motif; other site 441771008903 Anticodon-binding domain of valyl tRNA synthetases; Region: Anticodon_Ia_Val; cd07962 441771008904 tRNA binding surface [nucleotide binding]; other site 441771008905 anticodon binding site; other site 441771008906 Valyl tRNA synthetase tRNA binding arm; Region: Val_tRNA-synt_C; pfam10458 441771008907 Acetyltransferase (GNAT) domain; Region: Acetyltransf_3; pfam13302 441771008908 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 441771008909 Coenzyme A binding pocket [chemical binding]; other site 441771008910 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl17182 441771008911 ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136 441771008912 ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255 441771008913 Walker A/P-loop; other site 441771008914 ATP binding site [chemical binding]; other site 441771008915 Q-loop/lid; other site 441771008916 ABC transporter signature motif; other site 441771008917 Walker B; other site 441771008918 D-loop; other site 441771008919 H-loop/switch region; other site 441771008920 ABC-type nitrate/sulfonate/bicarbonate transport systems, periplasmic components [Inorganic ion transport and metabolism]; Region: TauA; COG0715 441771008921 NMT1-like family; Region: NMT1_2; cl17432 441771008922 Calponin homology domain; actin-binding domain which may be present as a single copy or in tandem repeats (which increases binding affinity). The CH domain is found in cytoskeletal and signal transduction proteins, including actin-binding proteins like...; Region: CH; cl00030 441771008923 putative actin binding surface [polypeptide binding]; other site 441771008924 BadF/BadG/BcrA/BcrD ATPase family; Region: BcrAD_BadFG; cl17271 441771008925 Activator of 2-hydroxyglutaryl-CoA dehydratase (HSP70-class ATPase domain) [Lipid metabolism]; Region: COG1924 441771008926 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3580 441771008927 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3581 441771008928 ABC-type nitrate/sulfonate/bicarbonate transport system, ATPase component [Inorganic ion transport and metabolism]; Region: TauB; COG1116 441771008929 ATP-binding cassette domain of the nitrate and sulfonate transporters; Region: ABC_NrtD_SsuB_transporters; cd03293 441771008930 Walker A/P-loop; other site 441771008931 ATP binding site [chemical binding]; other site 441771008932 Q-loop/lid; other site 441771008933 ABC transporter signature motif; other site 441771008934 Walker B; other site 441771008935 D-loop; other site 441771008936 H-loop/switch region; other site 441771008937 ABC-type nitrate/sulfonate/bicarbonate transport system, permease component [Inorganic ion transport and metabolism]; Region: TauC; COG0600 441771008938 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 441771008939 dimer interface [polypeptide binding]; other site 441771008940 conserved gate region; other site 441771008941 putative PBP binding loops; other site 441771008942 ABC-ATPase subunit interface; other site 441771008943 Tetratricopeptide repeat; Region: TPR_12; pfam13424 441771008944 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 441771008945 binding surface 441771008946 TPR motif; other site 441771008947 Transglutaminase-like enzymes, putative cysteine proteases [Amino acid transport and metabolism]; Region: COG1305 441771008948 Transglutaminase-like superfamily; Region: Transglut_core; pfam01841 441771008949 recombination regulator RecX; Provisional; Region: recX; PRK14134 441771008950 Predicted Zn-dependent peptidases [General function prediction only]; Region: PqqL; COG0612 441771008951 Insulinase (Peptidase family M16); Region: Peptidase_M16; pfam00675 441771008952 Peptidase M16 inactive domain; Region: Peptidase_M16_C; pfam05193 441771008953 QueT transporter; Region: QueT; pfam06177 441771008954 Conserved protein/domain typically associated with flavoprotein oxygenases, DIM6/NTAB family [General function prediction only]; Region: COG1853 441771008955 L,D-transpeptidase catalytic domain; Region: YkuD; pfam03734 441771008956 Uncharacterized protein conserved in bacteria [Function unknown]; Region: ErfK; COG1376 441771008957 Putative peptidoglycan binding domain; Region: PG_binding_1; pfam01471 441771008958 Sulfite exporter TauE/SafE; Region: TauE; pfam01925 441771008959 Sulfite exporter TauE/SafE; Region: TauE; pfam01925 441771008960 Protein of unknown function (DUF1255); Region: DUF1255; pfam06865 441771008961 pyrroline-5-carboxylate reductase; Reviewed; Region: PRK11880 441771008962 NADP oxidoreductase coenzyme F420-dependent; Region: F420_oxidored; pfam03807 441771008963 Pyrroline-5-carboxylate reductase dimerization; Region: P5CR_dimer; pfam14748 441771008964 glycyl radical enzyme, PFL2/glycerol dehydratase family; Region: PFL2-3; TIGR01774 441771008965 Pyruvate formate lyase 2 and related enzymes; Region: PFL2_DhaB_BssA; cd01677 441771008966 dimer interface [polypeptide binding]; other site 441771008967 active site 441771008968 glycine loop; other site 441771008969 glycyl-radical enzyme activating protein family; Region: PFLE_PFLC; TIGR02494 441771008970 The HCP family of iron-sulfur proteins includes hybrid cluster protein (HCP), acetyl-CoA synthase (ACS), and carbon monoxide dehydrogenase (CODH), all of which contain [Fe4-S4] metal clusters at their active sites. These proteins have a conserved...; Region: HCP_like; cl19102 441771008971 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 441771008972 FeS/SAM binding site; other site 441771008973 DNA-binding transcriptional repressor PuuR; Provisional; Region: PRK09943 441771008974 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 441771008975 non-specific DNA binding site [nucleotide binding]; other site 441771008976 salt bridge; other site 441771008977 sequence-specific DNA binding site [nucleotide binding]; other site 441771008978 Cupin domain; Region: Cupin_2; pfam07883 441771008979 Breast Cancer Suppressor Protein (BRCA1), carboxy-terminal domain. The BRCT domain is found within many DNA damage repair and cell cycle checkpoint proteins. The unique diversity of this domain superfamily allows BRCT modules to interact forming homo...; Region: BRCT; cd00027 441771008980 Dimer interface [polypeptide binding]; other site 441771008981 BRCT sequence motif; other site 441771008982 Amidinotransferase; Region: Amidinotransf; cl19186 441771008983 Aphid transmission protein; Region: Cauli_AT; pfam03233 441771008984 Protein of unknown function (DUF342); Region: DUF342; cl19219 441771008985 Von Willebrand factor type A (vWA) domain was originally found in the blood coagulation protein von Willebrand factor (vWF). Typically, the vWA domain is made up of approximately 200 amino acid residues folded into a classic a/b para-rossmann type of...; Region: vWFA; cl00057 441771008986 metal ion-dependent adhesion site (MIDAS); other site 441771008987 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 441771008988 ATPases associated with a variety of cellular activities; Region: AAA; smart00382 441771008989 Walker A motif; other site 441771008990 ATP binding site [chemical binding]; other site 441771008991 Walker B motif; other site 441771008992 arginine finger; other site 441771008993 Saccharopine dehydrogenase N-terminal domain; Region: SDH_N_domain; cl19054 441771008994 Saccharopine dehydrogenase N-terminal domain; Region: SDH_N_domain; cl19054 441771008995 4Fe-4S single cluster domain; Region: Fer4_15; pfam13459 441771008996 CoA enzyme activase uncharacterized domain (DUF2229); Region: DUF2229; pfam09989 441771008997 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3581 441771008998 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3581 441771008999 Activator of 2-hydroxyglutaryl-CoA dehydratase (HSP70-class ATPase domain) [Lipid metabolism]; Region: COG1924 441771009000 Transcriptional regulators containing an AAA-type ATPase domain and a DNA-binding domain [Transcription / Signal transduction mechanisms]; Region: PspF; COG1221 441771009001 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 441771009002 Walker A motif; other site 441771009003 ATP binding site [chemical binding]; other site 441771009004 Walker B motif; other site 441771009005 arginine finger; other site 441771009006 Bacterial regulatory protein, Fis family; Region: HTH_8; pfam02954 441771009007 Electron transfer flavoprotein, alpha subunit [Energy production and conversion]; Region: FixB; COG2025 441771009008 The electron transfer flavoprotein (ETF) serves as a specific electron acceptor for various mitochondrial dehydrogenases. ETF transfers electrons to the main respiratory chain via ETF-ubiquinone oxidoreductase. ETF is an heterodimer that consists of an...; Region: ETF_alpha; cd01715 441771009009 Electron transfer flavoprotein FAD-binding domain; Region: ETF_alpha; pfam00766 441771009010 The electron transfer flavoprotein (ETF) serves as a specific electron acceptor for various mitochondrial dehydrogenases. ETF transfers electrons to the main respiratory chain via ETF-ubiquinone oxidoreductase. ETF is an heterodimer that consists of an...; Region: ETF_beta; cd01714 441771009011 Ligand binding site [chemical binding]; other site 441771009012 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 441771009013 Short chain acyl-CoA dehydrogenases and eukaryotic short/branched chain acyl-CoA dehydrogenases; Region: SCAD_SBCAD; cd01158 441771009014 FAD binding site [chemical binding]; other site 441771009015 homotetramer interface [polypeptide binding]; other site 441771009016 substrate binding pocket [chemical binding]; other site 441771009017 catalytic base [active] 441771009018 putative acyltransferase; Provisional; Region: PRK05790 441771009019 Thiolase are ubiquitous enzymes that catalyze the reversible thiolytic cleavage of 3-ketoacyl-CoA into acyl-CoA and acetyl-CoA, a 2-step reaction involving a covalent intermediate formed with a catalytic cysteine. They are found in prokaryotes and...; Region: thiolase; cd00751 441771009020 dimer interface [polypeptide binding]; other site 441771009021 active site 441771009022 3-hydroxybutyryl-CoA dehydrogenase; Validated; Region: PRK05808 441771009023 3-hydroxyacyl-CoA dehydrogenase, NAD binding domain; Region: 3HCDH_N; pfam02737 441771009024 3-hydroxyacyl-CoA dehydrogenase, C-terminal domain; Region: 3HCDH; pfam00725 441771009025 3-hydroxybutyryl-CoA dehydratase; Validated; Region: PRK05809 441771009026 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 441771009027 substrate binding site [chemical binding]; other site 441771009028 oxyanion hole (OAH) forming residues; other site 441771009029 trimer interface [polypeptide binding]; other site 441771009030 Catalytic GIY-YIG domain of nucleotide excision repair endonucleases UvrC, Cho, and similar proteins; Region: GIY-YIG_UvrC_Cho; cd10434 441771009031 GIY-YIG motif/motif A; other site 441771009032 active site 441771009033 catalytic site [active] 441771009034 putative DNA binding site [nucleotide binding]; other site 441771009035 metal binding site [ion binding]; metal-binding site 441771009036 Xanthine/uracil/vitamin C permease [Nucleotide transport and metabolism]; Region: COG2252 441771009037 Predicted HD-superfamily hydrolase [General function prediction only]; Region: COG3481 441771009038 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 441771009039 Zn2+ binding site [ion binding]; other site 441771009040 Mg2+ binding site [ion binding]; other site 441771009041 prolipoprotein diacylglyceryl transferase; Reviewed; Region: PRK12437 441771009042 Escherichia coli YfcE and related proteins, metallophosphatase domain; Region: MPP_YfcE; cd00841 441771009043 homotetramer interface [polypeptide binding]; other site 441771009044 active site 441771009045 metal binding site [ion binding]; metal-binding site 441771009046 Glycerophosphoryl diester phosphodiesterase [Energy production and conversion]; Region: UgpQ; COG0584 441771009047 Catalytic domain of phosphoinositide-specific phospholipase C-like phosphodiesterases superfamily; Region: PI-PLCc_GDPD_SF; cl14615 441771009048 active site 441771009049 catalytic site [active] 441771009050 Cache domain; Region: Cache_1; pfam02743 441771009051 HAMP domain; Region: HAMP; pfam00672 441771009052 Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer); Region: MA; smart00283 441771009053 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 441771009054 dimer interface [polypeptide binding]; other site 441771009055 putative CheW interface [polypeptide binding]; other site 441771009056 Rubredoxin [Energy production and conversion]; Region: COG1773 441771009057 Rubredoxin, Small Modular nonheme iron binding domain containing a [Fe(SCys)4] center, present in rubrerythrin and nigerythrin and detected either N- or C-terminal to such proteins as flavin reductase, NAD(P)H-nitrite reductase, and...; Region: rubredoxin_SM; cd00729 441771009058 iron binding site [ion binding]; other site 441771009059 Rubrerythrin [Energy production and conversion]; Region: COG1592 441771009060 rubrerythrin-like, diiron-binding domain; Region: Rubrerythrin_like; cd01046 441771009061 diiron binding motif [ion binding]; other site 441771009062 pyruvate formate-lyase 1-activating enzyme; Region: PFLA; TIGR02493 441771009063 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 441771009064 FeS/SAM binding site; other site 441771009065 formate acetyltransferase 1; Region: pyr_form_ly_1; TIGR01255 441771009066 Pyruvate formate lyase 1; Region: PFL1; cd01678 441771009067 coenzyme A binding site [chemical binding]; other site 441771009068 active site 441771009069 catalytic residues [active] 441771009070 glycine loop; other site 441771009071 50S ribosomal protein L25/general stress protein Ctc; Reviewed; Region: PRK05618 441771009072 Ribosomal L25/TL5/CTC N-terminal 5S rRNA binding domain; Region: Ribosomal_L25_TL5_CTC; cd00495 441771009073 5S rRNA interface [nucleotide binding]; other site 441771009074 CTC domain interface [polypeptide binding]; other site 441771009075 L16 interface [polypeptide binding]; other site 441771009076 Ribosomal protein TL5, C-terminal domain; Region: Ribosomal_TL5_C; pfam14693 441771009077 Ferric uptake regulator(Fur) and related metalloregulatory proteins; typically iron-dependent, DNA-binding repressors and activators; Region: Fur_like; cd07153 441771009078 metal binding site 2 [ion binding]; metal-binding site 441771009079 putative DNA binding helix; other site 441771009080 metal binding site 1 [ion binding]; metal-binding site 441771009081 dimer interface [polypeptide binding]; other site 441771009082 structural Zn2+ binding site [ion binding]; other site 441771009083 ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653 441771009084 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; pfam01547 441771009085 Predicted transcriptional regulator [Transcription]; Region: COG2378 441771009086 HTH domain; Region: HTH_11; pfam08279 441771009087 WYL domain; Region: WYL; pfam13280 441771009088 CAAX protease self-immunity; Region: Abi; pfam02517 441771009089 Predicted GTPase [General function prediction only]; Region: COG0218 441771009090 YihA (EngB) GTPase family; Region: YihA_EngB; cd01876 441771009091 G1 box; other site 441771009092 GTP/Mg2+ binding site [chemical binding]; other site 441771009093 Switch I region; other site 441771009094 G2 box; other site 441771009095 G3 box; other site 441771009096 Switch II region; other site 441771009097 G4 box; other site 441771009098 G5 box; other site 441771009099 ATP-dependent Lon protease, bacterial type [Posttranslational modification, protein turnover, chaperones]; Region: Lon; COG0466 441771009100 ATP-dependent protease La (LON) domain; Region: LON; pfam02190 441771009101 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 441771009102 Walker A motif; other site 441771009103 ATP binding site [chemical binding]; other site 441771009104 Walker B motif; other site 441771009105 arginine finger; other site 441771009106 Lon protease (S16) C-terminal proteolytic domain; Region: Lon_C; pfam05362 441771009107 ATP-dependent protease LonB; Region: spore_lonB; TIGR02902 441771009108 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 441771009109 Walker A motif; other site 441771009110 ATP binding site [chemical binding]; other site 441771009111 Walker B motif; other site 441771009112 arginine finger; other site 441771009113 Lon protease (S16) C-terminal proteolytic domain; Region: Lon_C; pfam05362 441771009114 ATP-dependent protease ATP-binding subunit ClpX; Provisional; Region: clpX; PRK05342 441771009115 ClpX C4-type zinc finger; Region: zf-C4_ClpX; pfam06689 441771009116 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 441771009117 Walker A motif; other site 441771009118 ATP binding site [chemical binding]; other site 441771009119 Walker B motif; other site 441771009120 C-terminal, D2-small domain, of ClpB protein; Region: ClpB_D2-small; smart01086 441771009121 Caseinolytic protease (ClpP) is an ATP-dependent, highly conserved serine protease; Region: S14_ClpP_2; cd07017 441771009122 oligomer interface [polypeptide binding]; other site 441771009123 active site residues [active] 441771009124 trigger factor; Provisional; Region: tig; PRK01490 441771009125 Bacterial trigger factor protein (TF); Region: Trigger_N; pfam05697 441771009126 FKBP-type peptidyl-prolyl cis-trans isomerase; Region: FKBP_C; pfam00254 441771009127 Bacterial trigger factor protein (TF) C-terminus; Region: Trigger_C; pfam05698 441771009128 Sugar phosphate isomerases/epimerases [Carbohydrate transport and metabolism]; Region: IolE; COG1082 441771009129 Xylose isomerase-like TIM barrel; Region: AP_endonuc_2; pfam01261 441771009130 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 441771009131 active site 441771009132 Dihydroorotate dehydrogenase (DHOD) class 1B FMN-binding domain. DHOD catalyzes the oxidation of (S)-dihydroorotate to orotate. This is the fourth step and the only redox reaction in the de novo biosynthesis of UMP, the precursor of all pyrimidine...; Region: DHOD_1B_like; cd04740 441771009133 heterodimer interface [polypeptide binding]; other site 441771009134 active site 441771009135 FMN binding site [chemical binding]; other site 441771009136 homodimer interface [polypeptide binding]; other site 441771009137 substrate binding site [chemical binding]; other site 441771009138 dihydroorotate dehydrogenase electron transfer subunit; Reviewed; Region: PRK00054 441771009139 FAD/NAD binding domain in the electron transfer subunit of dihydroorotate dehydrogenase. Dihydroorotate dehydrogenases (DHODs) catalyze the only redox reaction in pyrimidine de novo biosynthesis. They catalyze the oxidation of (S)-dihydroorotate to...; Region: DHOD_e_trans; cd06218 441771009140 FAD binding pocket [chemical binding]; other site 441771009141 FAD binding motif [chemical binding]; other site 441771009142 phosphate binding motif [ion binding]; other site 441771009143 beta-alpha-beta structure motif; other site 441771009144 NAD binding pocket [chemical binding]; other site 441771009145 Iron coordination center [ion binding]; other site 441771009146 Orotidine 5'-phosphate decarboxylase (ODCase) is a dimeric enzyme that decarboxylates orotidine 5'-monophosphate (OMP) to form uridine 5'-phosphate (UMP), an essential step in the pyrimidine biosynthetic pathway. In mammals, UMP synthase...; Region: OMP_decarboxylase_like; cd04725 441771009147 active site 441771009148 dimer interface [polypeptide binding]; other site 441771009149 dihydroorotase; Validated; Region: pyrC; PRK09357 441771009150 Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281 441771009151 Dihydroorotase (DHOase), subgroup IIa; DHOases catalyze the reversible interconversion of carbamoyl aspartate to dihydroorotate, a key reaction in pyrimidine biosynthesis. This subgroup also contains proteins that lack the active site, like unc-33, a C; Region: DHOase_IIa; cd01317 441771009152 active site 441771009153 aspartate carbamoyltransferase regulatory subunit; Reviewed; Region: PRK00893 441771009154 Aspartate carbamoyltransferase regulatory chain, allosteric domain; Region: PyrI; pfam01948 441771009155 Aspartate carbamoyltransferase regulatory chain, metal binding domain; Region: PyrI_C; pfam02748 441771009156 aspartate carbamoyltransferase catalytic subunit; Provisional; Region: pyrB; PRK00856 441771009157 Aspartate/ornithine carbamoyltransferase, carbamoyl-P binding domain; Region: OTCace_N; pfam02729 441771009158 Aspartate/ornithine carbamoyltransferase, Asp/Orn binding domain; Region: OTCace; pfam00185 441771009159 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cd00012 441771009160 nucleotide binding site [chemical binding]; other site 441771009161 BadF/BadG/BcrA/BcrD ATPase family; Region: BcrAD_BadFG; cl17271 441771009162 Protein of unknown function (DUF3343); Region: DUF3343; pfam11823 441771009163 Benzoyl-CoA reductase/2-hydroxyglutaryl-CoA dehydratase subunit, BcrC/BadD/HgdB [Amino acid transport and metabolism]; Region: HgdB; COG1775 441771009164 2-hydroxyglutaryl-CoA dehydratase, D-component; Region: HGD-D; pfam06050 441771009165 Benzoyl-CoA reductase/2-hydroxyglutaryl-CoA dehydratase subunit, BcrC/BadD/HgdB [Amino acid transport and metabolism]; Region: HgdB; COG1775 441771009166 2-hydroxyglutaryl-CoA dehydratase, D-component; Region: HGD-D; pfam06050 441771009167 DsrE/DsrF-like family; Region: DrsE; pfam02635 441771009168 ABC-type nitrate/sulfonate/bicarbonate transport system, ATPase component [Inorganic ion transport and metabolism]; Region: TauB; COG1116 441771009169 ATP-binding cassette domain of the nitrate and sulfonate transporters; Region: ABC_NrtD_SsuB_transporters; cd03293 441771009170 Walker A/P-loop; other site 441771009171 ATP binding site [chemical binding]; other site 441771009172 Q-loop/lid; other site 441771009173 ABC transporter signature motif; other site 441771009174 Walker B; other site 441771009175 D-loop; other site 441771009176 H-loop/switch region; other site 441771009177 Alkylmercury lyase; Region: MerB; pfam03243 441771009178 ABC-type nitrate/sulfonate/bicarbonate transport systems, periplasmic components [Inorganic ion transport and metabolism]; Region: TauA; COG0715 441771009179 NMT1-like family; Region: NMT1_2; cl17432 441771009180 Prokaryotic membrane lipoprotein lipid attachment site; Region: LPAM_1; pfam08139 441771009181 Predicted permeases [General function prediction only]; Region: COG0701 441771009182 Escherichia coli YfcE and related proteins, metallophosphatase domain; Region: MPP_YfcE; cd00841 441771009183 active site 441771009184 metal binding site [ion binding]; metal-binding site 441771009185 homotetramer interface [polypeptide binding]; other site 441771009186 NTPase/HAM1. This family consists of the HAM1 protein and pyrophosphate-releasing xanthosine/ inosine triphosphatase. HAM1 protects the cell against mutagenesis by the base analog 6-N-hydroxylaminopurine (HAP) in E. Coli and S. cerevisiae. A...; Region: HAM1; cd00515 441771009187 active site 441771009188 dimerization interface [polypeptide binding]; other site 441771009189 ABC-type oligopeptide transport system, periplasmic component [Amino acid transport and metabolism]; Region: OppA; COG4166 441771009190 The substrate-binding component of an ABC-type oligopetide import system contains the type 2 periplasmic binding fold; Region: PBP2_OppA; cd08504 441771009191 peptide binding site [polypeptide binding]; other site 441771009192 aspartyl/glutamyl-tRNA amidotransferase subunit B; Validated; Region: gatB; PRK05477 441771009193 GatB/GatE catalytic domain; Region: GatB_N; pfam02934 441771009194 GatB domain; Region: GatB_Yqey; smart00845 441771009195 aspartyl/glutamyl-tRNA amidotransferase subunit A; Reviewed; Region: gatA; PRK00012 441771009196 aspartyl/glutamyl-tRNA amidotransferase subunit C; Reviewed; Region: gatC; PRK00034 441771009197 Sodium:dicarboxylate symporter family; Region: SDF; pfam00375 441771009198 NAD-dependent DNA ligase LigA; Validated; Region: ligA; PRK07956 441771009199 NAD+ dependent DNA ligase adenylation domain. DNA ligases catalyze the crucial step of joining the breaks in duplex DNA during DNA replication, repair and recombination, utilizing either ATP or NAD(+) as a cofactor, but using the same basic reaction...; Region: LIGANc; cd00114 441771009200 nucleotide binding pocket [chemical binding]; other site 441771009201 K-X-D-G motif; other site 441771009202 catalytic site [active] 441771009203 NAD-dependent DNA ligase OB-fold domain; Region: DNA_ligase_OB; pfam03120 441771009204 NAD-dependent DNA ligase C4 zinc finger domain; Region: DNA_ligase_ZBD; pfam03119 441771009205 Helix-hairpin-helix domain; Region: HHH_5; pfam14520 441771009206 H3TH domains of Flap endonuclease-1 (FEN1)-like structure specific 5' nucleases; Region: H3TH_FEN1-XPG-like; cd09897 441771009207 putative DNA binding site [nucleotide binding]; other site 441771009208 metal binding site [ion binding]; metal-binding site 441771009209 Helix-hairpin-helix motif; Region: HHH; pfam00633 441771009210 Breast Cancer Suppressor Protein (BRCA1), carboxy-terminal domain. The BRCT domain is found within many DNA damage repair and cell cycle checkpoint proteins. The unique diversity of this domain superfamily allows BRCT modules to interact forming homo...; Region: BRCT; cd00027 441771009211 Dimer interface [polypeptide binding]; other site 441771009212 ATP-dependent DNA helicase PcrA; Region: pcrA; TIGR01073 441771009213 Part of AAA domain; Region: AAA_19; pfam13245 441771009214 UvrD-like helicase C-terminal domain; Region: UvrD_C_2; pfam13538 441771009215 Trp repressor protein; Region: Trp_repressor; cl17266 441771009216 16S rRNA uridine-516 pseudouridylate synthase and related pseudouridylate synthases [Translation, ribosomal structure and biogenesis]; Region: RsuA; COG1187 441771009217 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 441771009218 RNA binding surface [nucleotide binding]; other site 441771009219 Pseudouridine synthase, Escherichia coli RsuA like; Region: PseudoU_synth_RsuA; cd02553 441771009220 active site 441771009221 uracil binding [chemical binding]; other site 441771009222 lysozyme_like domain. This contains several members including Soluble Lytic Transglycosylases (SLT), Goose Egg-White Lysozymes (GEWL), Hen Egg-White Lysozymes (HEWL), chitinases, bacteriophage lambda lysozymes, endolysins, autolysins, and chitosanases; Region: lysozyme_like; cl00222 441771009223 Soluble lytic murein transglycosylase and related regulatory proteins (some contain LysM/invasin domains) [Cell envelope biogenesis, outer membrane]; Region: MltE; COG0741 441771009224 Lytic Transglycosylase (LT) and Goose Egg White Lysozyme (GEWL) domain. Members include the soluble and insoluble membrane-bound LTs in bacteria, the LTs in bacteriophage lambda, as well as, the eukaryotic "goose-type" lysozymes (GEWL). LTs...; Region: LT_GEWL; cd00254 441771009225 N-acetyl-D-glucosamine binding site [chemical binding]; other site 441771009226 catalytic residue [active] 441771009227 triple tyrosine motif-containing protein; Provisional; Region: PRK14081 441771009228 Y_Y_Y domain; Region: Y_Y_Y; pfam07495 441771009229 Y_Y_Y domain; Region: Y_Y_Y; pfam07495 441771009230 Y_Y_Y domain; Region: Y_Y_Y; pfam07495 441771009231 Y_Y_Y domain; Region: Y_Y_Y; pfam07495 441771009232 Y_Y_Y domain; Region: Y_Y_Y; pfam07495 441771009233 hypothetical protein; Validated; Region: PRK00124 441771009234 glucose-6-phosphate isomerase; Provisional; Region: pgi; PRK14097 441771009235 Phosphoglucose isomerase (PGI) contains two SIS (Sugar ISomerase) domains. This classification is based on the alignment of the first SIS domain. PGI is a multifunctional enzyme which as an intracellular dimer catalyzes the reversible isomerization of...; Region: SIS_PGI_1; cd05015 441771009236 active site 441771009237 dimer interface [polypeptide binding]; other site 441771009238 Phosphoglucose isomerase (PGI) contains two SIS (Sugar ISomerase) domains. This classification is based on the alignment of the second SIS domain. PGI is a multifunctional enzyme which as an intracellular dimer catalyzes the reversible isomerization of...; Region: SIS_PGI_2; cd05016 441771009239 dimer interface [polypeptide binding]; other site 441771009240 active site 441771009241 Probable zinc-binding domain; Region: zf-trcl; pfam13451 441771009242 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 441771009243 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 441771009244 D-lactate dehydrogenase; Validated; Region: PRK08605 441771009245 D-Lactate dehydrogenase and D-2-Hydroxyisocaproic acid dehydrogenase (D-HicDH), NAD-binding and catalytic domains; Region: LDH; cd12186 441771009246 homodimer interface [polypeptide binding]; other site 441771009247 ligand binding site [chemical binding]; other site 441771009248 NAD binding site [chemical binding]; other site 441771009249 catalytic site [active] 441771009250 Lactate dehydrogenase and related dehydrogenases [Energy production and conversion / Coenzyme metabolism / General function prediction only]; Region: LdhA; COG1052 441771009251 Putative Lactate dehydrogenase and (R)-2-Hydroxyglutarate Dehydrogenase-like proteins, NAD-binding and catalytic domains; Region: HGDH_LDH_like; cd12185 441771009252 putative ligand binding site [chemical binding]; other site 441771009253 putative NAD binding site [chemical binding]; other site 441771009254 catalytic site [active] 441771009255 Solute carrier families 5 and 6-like; solute binding domain; Region: SLC5-6-like_sbd; cl00456 441771009256 Amino acid transporters [Amino acid transport and metabolism]; Region: PotE; COG0531 441771009257 Na binding site [ion binding]; other site 441771009258 4Fe-4S dicluster domain; Region: Fer4_9; pfam13187 441771009259 The HCP family of iron-sulfur proteins includes hybrid cluster protein (HCP), acetyl-CoA synthase (ACS), and carbon monoxide dehydrogenase (CODH), all of which contain [Fe4-S4] metal clusters at their active sites. These proteins have a conserved...; Region: HCP_like; cl19102 441771009260 Electron transfer flavoprotein, alpha subunit [Energy production and conversion]; Region: FixB; COG2025 441771009261 The electron transfer flavoprotein (ETF) serves as a specific electron acceptor for various mitochondrial dehydrogenases. ETF transfers electrons to the main respiratory chain via ETF-ubiquinone oxidoreductase. ETF is an heterodimer that consists of an...; Region: ETF_alpha; cd01715 441771009262 Electron transfer flavoprotein FAD-binding domain; Region: ETF_alpha; pfam00766 441771009263 The electron transfer flavoprotein (ETF) serves as a specific electron acceptor for various mitochondrial dehydrogenases. ETF transfers electrons to the main respiratory chain via ETF-ubiquinone oxidoreductase. ETF is an heterodimer that consists of an...; Region: ETF_beta; cd01714 441771009264 Ligand binding site [chemical binding]; other site 441771009265 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 441771009266 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 441771009267 active site 441771009268 Benzoyl-CoA reductase/2-hydroxyglutaryl-CoA dehydratase subunit, BcrC/BadD/HgdB [Amino acid transport and metabolism]; Region: HgdB; COG1775 441771009269 2-hydroxyglutaryl-CoA dehydratase, D-component; Region: HGD-D; pfam06050 441771009270 Benzoyl-CoA reductase/2-hydroxyglutaryl-CoA dehydratase subunit, BcrC/BadD/HgdB [Amino acid transport and metabolism]; Region: HgdB; COG1775 441771009271 2-hydroxyglutaryl-CoA dehydratase, D-component; Region: HGD-D; pfam06050 441771009272 BadF/BadG/BcrA/BcrD ATPase family; Region: BcrAD_BadFG; cl17271 441771009273 Predicted acyl-CoA transferases/carnitine dehydratase [Energy production and conversion]; Region: CaiB; COG1804 441771009274 AMP-binding domain protein; Validated; Region: PRK08315 441771009275 Uncharacterized subfamily of fatty acid CoA ligase (FACL); Region: FACL_like_2; cd05917 441771009276 acyl-activating enzyme (AAE) consensus motif; other site 441771009277 putative AMP binding site [chemical binding]; other site 441771009278 putative active site [active] 441771009279 putative CoA binding site [chemical binding]; other site 441771009280 Branched-chain amino acid transport protein; Region: Branch_AA_trans; cl00547 441771009281 GMP synthase; Reviewed; Region: guaA; PRK00074 441771009282 Type 1 glutamine amidotransferase (GATase1) domain found in GMP synthetase; Region: GATase1_GMP_Synthase; cd01742 441771009283 AMP/PPi binding site [chemical binding]; other site 441771009284 candidate oxyanion hole; other site 441771009285 catalytic triad [active] 441771009286 potential glutamine specificity residues [chemical binding]; other site 441771009287 The C-terminal domain of GMP synthetase. It contains two subdomains; the ATP pyrophosphatase domain which closes to the N-termial and the dimerization domain at C-terminal end. The ATP-PPase is a twisted, five-stranded parallel beta-sheet sandwiched...; Region: GMP_synthase_C; cd01997 441771009288 ATP Binding subdomain [chemical binding]; other site 441771009289 Ligand Binding sites [chemical binding]; other site 441771009290 Dimerization subdomain; other site 441771009291 inosine 5'-monophosphate dehydrogenase; Reviewed; Region: PRK05567 441771009292 IMPDH: The catalytic domain of the inosine monophosphate dehydrogenase. IMPDH catalyzes the NAD-dependent oxidation of inosine 5'-monophosphate (IMP) to xanthosine 5' monophosphate (XMP). It is a rate-limiting step in the de novo synthesis of...; Region: IMPDH; cd00381 441771009293 active site 441771009294 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains in the inosine 5' monophosphate dehydrogenase (IMPDH) protein. IMPDH is an essential enzyme that catalyzes the first step unique to GTP synthesis, playing a...; Region: CBS_pair_IMPDH; cd04601 441771009295 tRNA 2-thiocytidine biosynthesis protein TtcA; Provisional; Region: PRK10696 441771009296 This is a subfamily of Adenine nucleotide alpha hydrolases superfamily.Adeninosine nucleotide alpha hydrolases superfamily includes N type ATP PPases and ATP sulphurylases. It forms a apha/beta/apha fold which binds to Adenosine group. This subfamily; Region: Alpha_ANH_like_II; cd01993 441771009297 Ligand Binding Site [chemical binding]; other site 441771009298 TIGR00269 family protein; Region: TIGR00269 441771009299 chaperonin GroEL; Reviewed; Region: groEL; PRK12850 441771009300 GroEL_like type I chaperonin. Chaperonins are involved in productive folding of proteins. They share a common general morphology, a double toroid of 2 stacked rings, each composed of 7-9 subunits. The symmetry of type I is seven-fold and they are found...; Region: GroEL; cd03344 441771009301 ring oligomerisation interface [polypeptide binding]; other site 441771009302 ATP/Mg binding site [chemical binding]; other site 441771009303 stacking interactions; other site 441771009304 hinge regions; other site 441771009305 Chaperonin 10 Kd subunit (cpn10 or GroES); Cpn10 cooperates with chaperonin 60 (cpn60 or GroEL), an ATPase, to assist the folding and assembly of proteins and is found in eubacterial cytosol, as well as in the matrix of mitochondria and chloroplasts. It...; Region: cpn10; cd00320 441771009306 oligomerisation interface [polypeptide binding]; other site 441771009307 mobile loop; other site 441771009308 roof hairpin; other site 441771009309 Protein of unknown function (DUF1461); Region: DUF1461; pfam07314 441771009310 Uncharacterized conserved protein [Function unknown]; Region: COG0398 441771009311 [FeFe] hydrogenase, group B1/B3; Region: FeFe_hydrog_B1; TIGR04105 441771009312 The HCP family of iron-sulfur proteins includes hybrid cluster protein (HCP), acetyl-CoA synthase (ACS), and carbon monoxide dehydrogenase (CODH), all of which contain [Fe4-S4] metal clusters at their active sites. These proteins have a conserved...; Region: HCP_like; cl19102 441771009313 4Fe-4S double cluster binding domain; Region: Fer4_16; pfam13484 441771009314 Iron only hydrogenase large subunit, C-terminal domain; Region: Fe_hyd_lg_C; pfam02906 441771009315 3-methyladenine DNA glycosylase/8-oxoguanine DNA glycosylase [DNA replication, recombination, and repair]; Region: AlkA; COG0122 441771009316 8-oxoguanine DNA glycosylase, N-terminal domain; Region: OGG_N; pfam07934 441771009317 endonuclease III; includes endonuclease III (DNA-(apurinic or apyrimidinic site) lyase), alkylbase DNA glycosidases (Alka-family) and other DNA glycosidases; Region: ENDO3c; cd00056 441771009318 minor groove reading motif; other site 441771009319 helix-hairpin-helix signature motif; other site 441771009320 substrate binding pocket [chemical binding]; other site 441771009321 active site 441771009322 putative oxidoreductase; Provisional; Region: PRK12831 441771009323 Dihydroprymidine dehydrogenase domain II, 4Fe-4S cluster; Region: Fer4_20; pfam14691 441771009324 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl19134 441771009325 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 441771009326 ferredoxin-NADP(+) reductase subunit alpha; Reviewed; Region: PRK06222 441771009327 FAD/NAD binding domain in the electron transfer subunit of dihydroorotate dehydrogenase-like proteins. Dihydroorotate dehydrogenases (DHODs) catalyze the only redox reaction in pyrimidine de novo biosynthesis. They catalyze the oxidation of (S)...; Region: DHOD_e_trans_like1; cd06219 441771009328 FAD binding pocket [chemical binding]; other site 441771009329 FAD binding motif [chemical binding]; other site 441771009330 phosphate binding motif [ion binding]; other site 441771009331 beta-alpha-beta structure motif; other site 441771009332 NAD binding pocket [chemical binding]; other site 441771009333 Iron coordination center [ion binding]; other site 441771009334 redox-sensing transcriptional repressor Rex; Provisional; Region: PRK05472 441771009335 Putative DNA-binding protein N-terminus; Region: Put_DNA-bind_N; pfam06971 441771009336 CoA binding domain; Region: CoA_binding; pfam02629 441771009337 ATPase components of ABC transporters with duplicated ATPase domains [General function prediction only]; Region: Uup; COG0488 441771009338 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 441771009339 ABC transporter; Region: ABC_tran_2; pfam12848 441771009340 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 441771009341 Response regulator of the LytR/AlgR family [Transcription / Signal transduction mechanisms]; Region: LytT; COG3279 441771009342 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 441771009343 active site 441771009344 phosphorylation site [posttranslational modification] 441771009345 intermolecular recognition site; other site 441771009346 dimerization interface [polypeptide binding]; other site 441771009347 LytTr DNA-binding domain; Region: LytTR; pfam04397 441771009348 Putative regulator of cell autolysis [Signal transduction mechanisms]; Region: LytS; COG3275 441771009349 5TMR of 5TMR-LYT; Region: 5TM-5TMR_LYT; pfam07694 441771009350 Histidine kinase; Region: His_kinase; pfam06580 441771009351 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 441771009352 ATP binding site [chemical binding]; other site 441771009353 Mg2+ binding site [ion binding]; other site 441771009354 G-X-G motif; other site 441771009355 Carbon starvation protein, predicted membrane protein [Signal transduction mechanisms]; Region: CstA; COG1966 441771009356 Carbon starvation protein CstA; Region: CstA; pfam02554 441771009357 C-terminal domain on CstA (DUF4161); Region: DUF4161; pfam13722 441771009358 Predicted Zn-dependent peptidases, insulinase-like [General function prediction only]; Region: COG1026 441771009359 Insulinase (Peptidase family M16); Region: Peptidase_M16; pfam00675 441771009360 Peptidase M16 inactive domain; Region: Peptidase_M16_C; pfam05193 441771009361 Peptidase M16C associated; Region: M16C_assoc; pfam08367 441771009362 pyruvate carboxylase; Reviewed; Region: PRK12999 441771009363 Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289 441771009364 ATP-grasp domain; Region: ATP-grasp_4; cl17255 441771009365 Biotin carboxylase C-terminal domain; Region: Biotin_carb_C; smart00878 441771009366 Pyruvate carboxylase and Transcarboxylase 5S, carboxyltransferase domain; Region: DRE_TIM_PC_TC_5S; cd07937 441771009367 active site 441771009368 catalytic residues [active] 441771009369 metal binding site [ion binding]; metal-binding site 441771009370 homodimer binding site [polypeptide binding]; other site 441771009371 Conserved carboxylase domain; Region: PYC_OADA; pfam02436 441771009372 The biotinyl-domain or biotin carboxyl carrier protein (BCCP) domain is present in all biotin-dependent enzymes, such as acetyl-CoA carboxylase, pyruvate carboxylase, propionyl-CoA carboxylase, methylcrotonyl-CoA carboxylase, geranyl-CoA carboxylase; Region: biotinyl_domain; cd06850 441771009373 carboxyltransferase (CT) interaction site; other site 441771009374 biotinylation site [posttranslational modification]; other site 441771009375 UGMP family protein; Validated; Region: PRK09604 441771009376 tRNA threonylcarbamoyl adenosine modification protein YeaZ; Region: T6A_YeaZ; TIGR03725 441771009377 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cl17037 441771009378 Endodeoxyribonuclease RusA; Region: RusA; pfam05866 441771009379 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox_2; pfam07992 441771009380 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl19134 441771009381 zinc-ribbon domain; Region: zf-ribbon_3; pfam13248 441771009382 Double zinc ribbon; Region: DZR; pfam12773 441771009383 Domain of unknown function (DUF4389); Region: DUF4389; pfam14333 441771009384 ABC-type metal ion transport system, periplasmic component/surface adhesin [Inorganic ion transport and metabolism]; Region: LraI; COG0803 441771009385 Periplasmic solute binding protein family; Region: TroA; pfam01297 441771009386 intersubunit interface [polypeptide binding]; other site 441771009387 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 441771009388 Zn2+ binding site [ion binding]; other site 441771009389 Mg2+ binding site [ion binding]; other site 441771009390 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 441771009391 Zn2+ binding site [ion binding]; other site 441771009392 Mg2+ binding site [ion binding]; other site 441771009393 Predicted ATPase or kinase [General function prediction only]; Region: COG0802 441771009394 tRNA threonylcarbamoyl adenosine modification protein YeaZ; Region: T6A_YeaZ; TIGR03725 441771009395 Glycoprotease family; Region: Peptidase_M22; pfam00814 441771009396 ribosomal-protein-alanine acetyltransferase; Region: rimI; TIGR01575 441771009397 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 441771009398 Coenzyme A binding pocket [chemical binding]; other site 441771009399 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl17182 441771009400 tyrosyl-tRNA synthetase; Validated; Region: PRK05912 441771009401 catalytic core domain of tyrosinyl-tRNA synthetase; Region: TyrRS_core; cd00805 441771009402 active site 441771009403 HIGH motif; other site 441771009404 dimer interface [polypeptide binding]; other site 441771009405 KMSKS motif; other site 441771009406 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 441771009407 RNA binding surface [nucleotide binding]; other site 441771009408 Predicted transcriptional regulator containing an HTH domain and an uncharacterized domain shared with the mammalian protein Schlafen [Transcription]; Region: COG2865 441771009409 Divergent AAA domain; Region: AAA_4; pfam04326 441771009410 ECF-type riboflavin transporter, S component; Region: ECF-ribofla_trS; pfam07155 441771009411 PAP2_like proteins, Aur1_like subfamily. Yeast Aur1p or Ipc1p is necessary for the addition of inositol phosphate to ceramide, an essential step in yeast sphingolipid synthesis, and is the target of several antifungal compounds such as aureobasidin; Region: PAP2_Aur1_like; cd03386 441771009412 active site 441771009413 Membrane-associated phospholipid phosphatase [Lipid metabolism]; Region: PgpB; COG0671 441771009414 Peptide chain release factor RF-3 [Translation, ribosomal structure and biogenesis]; Region: PrfC; COG4108 441771009415 Release Factor 3 (RF3) protein involved in the terminal step of translocation in bacteria; Region: RF3; cd04169 441771009416 G1 box; other site 441771009417 putative GEF interaction site [polypeptide binding]; other site 441771009418 GTP/Mg2+ binding site [chemical binding]; other site 441771009419 Switch I region; other site 441771009420 G2 box; other site 441771009421 G3 box; other site 441771009422 Switch II region; other site 441771009423 G4 box; other site 441771009424 G5 box; other site 441771009425 RF3_II: this subfamily represents the domain II of bacterial Release Factor 3 (RF3). Termination of protein synthesis by the ribosome requires two release factor (RF) classes. The class II RF3 is a GTPase that removes class I RFs (RF1 or RF2) from the...; Region: RF3_II; cd03689 441771009426 sugar phosphate phosphatase; Provisional; Region: PRK10513 441771009427 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 441771009428 active site 441771009429 motif I; other site 441771009430 motif II; other site 441771009431 haloacid dehalogenase-like hydrolase; Region: HAD; cl19137 441771009432 tryptophanyl-tRNA synthetase; Reviewed; Region: PRK00927 441771009433 catalytic core domain of tryptophanyl-tRNA synthetase; Region: TrpRS_core; cd00806 441771009434 active site 441771009435 HIGH motif; other site 441771009436 dimer interface [polypeptide binding]; other site 441771009437 KMSKS motif; other site 441771009438 desulfoferrodoxin; Region: dfx_rbo; TIGR00320 441771009439 Desulforedoxin (DSRD) domain; a small non-heme iron domain present in the desulforedoxin (rubredoxin oxidoreductase) and desulfoferrodoxin proteins of some archeael and bacterial methanogens and sulfate/sulfur reducers. Desulforedoxin is a small; Region: DSRD; cd00974 441771009440 non-heme iron binding site [ion binding]; other site 441771009441 dimer interface [polypeptide binding]; other site 441771009442 Superoxide reductase-like (SORL) domain, class I; SORL-domains are present in a family of mononuclear non-heme iron proteins that includes superoxide reductase and desulfoferrodoxin. Superoxide reductase-like proteins scavenge superoxide anion radicals...; Region: SORL_Dfx_classI; cd03171 441771009443 non-heme iron binding site [ion binding]; other site 441771009444 dimer interface [polypeptide binding]; other site 441771009445 Protein of unknown function (DUF3131); Region: DUF3131; pfam11329 441771009446 Putative glucoamylase; Region: Glycoamylase; pfam10091 441771009447 Second GH94N domain of cyclic beta 1-2 glucan synthetase and similar domains; Region: GH94N_ChvB_NdvB_2_like; cd11753 441771009448 Cellobiose phosphorylase [Carbohydrate transport and metabolism]; Region: COG3459 441771009449 First GH94N domain of cyclic beta 1-2 glucan synthetase and similar domains; Region: GH94N_ChvB_NdvB_1_like; cd11756 441771009450 diaminopimelate decarboxylase; Region: lysA; TIGR01048 441771009451 Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzyme Diaminopimelate Decarboxylase; Region: PLPDE_III_DapDC; cd06828 441771009452 active site 441771009453 pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site 441771009454 substrate binding site [chemical binding]; other site 441771009455 catalytic residues [active] 441771009456 dimer interface [polypeptide binding]; other site 441771009457 aspartate kinase; Reviewed; Region: PRK06635 441771009458 AAK_AKii-LysC-BS: Amino Acid Kinase Superfamily (AAK), AKii; this CD includes the N-terminal catalytic aspartokinase (AK) domain of the lysine-sensitive aspartokinase isoenzyme AKII of Bacillus subtilis 168, and the lysine plus threonine-sensitive...; Region: AAK_AKii-LysC-BS; cd04261 441771009459 putative nucleotide binding site [chemical binding]; other site 441771009460 putative catalytic residues [active] 441771009461 putative Mg ion binding site [ion binding]; other site 441771009462 putative aspartate binding site [chemical binding]; other site 441771009463 ACT domains of the lysine-sensitive aspartokinase isoenzyme AKII and related proteins; Region: ACT_AK-LysC-DapG-like_1; cd04891 441771009464 ACT domains of the lysine-sensitive aspartokinase isoenzyme AKII of Bacillus subtilis (BS) strain 168 and related domains; Region: ACT_AK-LysC-DapG-like_2; cd04923 441771009465 M18 Peptidase Aspartyl aminopeptidase; Region: M18_DAP; cd05658 441771009466 active site 441771009467 metal binding site [ion binding]; metal-binding site 441771009468 Predicted Co/Zn/Cd cation transporters [Inorganic ion transport and metabolism]; Region: MMT1; COG0053 441771009469 hypothetical protein; Provisional; Region: PRK06851 441771009470 Superfamily I DNA and RNA helicases [General function prediction only]; Region: COG3973 441771009471 Part of AAA domain; Region: AAA_19; pfam13245 441771009472 FtsH Extracellular; Region: FtsH_ext; pfam06480 441771009473 ATP-dependent metalloprotease FtsH; Region: FtsH_fam; TIGR01241 441771009474 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 441771009475 Walker A motif; other site 441771009476 ATP binding site [chemical binding]; other site 441771009477 Walker B motif; other site 441771009478 arginine finger; other site 441771009479 Peptidase family M41; Region: Peptidase_M41; pfam01434 441771009480 dipeptidase PepV; Reviewed; Region: PRK07318 441771009481 M20 Peptidase Xaa-His dipeptidase (PepV) degrades hydrophobic dipeptides; Region: M20_PepV; cd03888 441771009482 active site 441771009483 metal binding site [ion binding]; metal-binding site 441771009484 prolyl-tRNA synthetase; Provisional; Region: PRK08661 441771009485 Prolyl-tRNA synthetase (ProRS) class II core catalytic domain. ProRS is a homodimer. It is responsible for the attachment of proline to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for ATP-dependent...; Region: ProRS_core_arch_euk; cd00778 441771009486 dimer interface [polypeptide binding]; other site 441771009487 motif 1; other site 441771009488 active site 441771009489 motif 2; other site 441771009490 motif 3; other site 441771009491 ProRS Prolyl-anticodon binding domain, long version found predominantly in eukaryotes and archaea. ProRS belongs to class II aminoacyl-tRNA synthetases (aaRS). This alignment contains the anticodon binding domain, which is responsible for specificity in...; Region: ProRS_anticodon_zinc; cd00862 441771009492 anticodon binding site; other site 441771009493 zinc-binding site [ion binding]; other site 441771009494 The GIY-YIG domain of uncharacterized protein family UPF0213 related to structure-specific endonuclease SLX1; Region: GIY-YIG_UPF0213; cd10456 441771009495 GIY-YIG motif/motif A; other site 441771009496 putative active site [active] 441771009497 putative metal binding site [ion binding]; other site 441771009498 putative transporter; Provisional; Region: PRK11660 441771009499 Sulfate transporter N-terminal domain with GLY motif; Region: Sulfate_tra_GLY; pfam13792 441771009500 Sulfate transporter family; Region: Sulfate_transp; pfam00916 441771009501 Sulphate Transporter and Anti-Sigma factor antagonist domain of SulP-like sulfate transporters, plays a role in the function and regulation of the transport activity, proposed general NTP binding function; Region: STAS_SulP_like_sulfate_transporter; cd07042 441771009502 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 441771009503 HAMP domain; Region: HAMP; pfam00672 441771009504 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 441771009505 dimer interface [polypeptide binding]; other site 441771009506 phosphorylation site [posttranslational modification] 441771009507 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 441771009508 ATP binding site [chemical binding]; other site 441771009509 Mg2+ binding site [ion binding]; other site 441771009510 G-X-G motif; other site 441771009511 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 441771009512 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 441771009513 active site 441771009514 phosphorylation site [posttranslational modification] 441771009515 intermolecular recognition site; other site 441771009516 dimerization interface [polypeptide binding]; other site 441771009517 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 441771009518 DNA binding site [nucleotide binding] 441771009519 WXG100 protein secretion system (Wss), protein EssA; Region: EssA; cl11266 441771009520 Acyltransferase family; Region: Acyl_transf_3; cl19154 441771009521 ABC-type multidrug transport system, ATPase component [Defense mechanisms]; Region: CcmA; COG1131 441771009522 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 441771009523 Walker A/P-loop; other site 441771009524 ATP binding site [chemical binding]; other site 441771009525 Q-loop/lid; other site 441771009526 ABC transporter signature motif; other site 441771009527 Walker B; other site 441771009528 D-loop; other site 441771009529 H-loop/switch region; other site 441771009530 Bacterial protein of unknown function (DUF871); Region: DUF871; pfam05913 441771009531 Transcriptional regulator/sugar kinase [Transcription / Carbohydrate transport and metabolism]; Region: NagC; COG1940 441771009532 BadF/BadG/BcrA/BcrD ATPase family; Region: BcrAD_BadFG; cl17271 441771009533 PTS_IIA, PTS system, lactose/cellobiose specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_lac; cd00215 441771009534 methionine cluster; other site 441771009535 active site 441771009536 phosphorylation site [posttranslational modification] 441771009537 metal binding site [ion binding]; metal-binding site 441771009538 PTS_IIB_chitobiose_lichenan: subunit IIB of enzyme II (EII) of the N,N-diacetylchitobiose-specific and lichenan-specific phosphoenolpyruvate:carbohydrate phosphotransferase system (PTS). In these systems, EII is either a lichenan- or an N; Region: PTS_IIB_chitobiose_lichenan; cd05564 441771009539 active site 441771009540 P-loop; other site 441771009541 phosphorylation site [posttranslational modification] 441771009542 Transcriptional regulators containing an AAA-type ATPase domain and a DNA-binding domain [Transcription / Signal transduction mechanisms]; Region: PspF; COG1221 441771009543 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 441771009544 Walker A motif; other site 441771009545 ATP binding site [chemical binding]; other site 441771009546 Walker B motif; other site 441771009547 arginine finger; other site 441771009548 Transcriptional antiterminator [Transcription]; Region: COG3933 441771009549 PRD domain; Region: PRD; pfam00874 441771009550 PTS_IIA, PTS system, mannose/sorbose specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIA_man; cd00006 441771009551 active pocket/dimerization site; other site 441771009552 active site 441771009553 phosphorylation site [posttranslational modification] 441771009554 PRD domain; Region: PRD; pfam00874 441771009555 Phosphotransferase system cellobiose-specific component IIC [Carbohydrate transport and metabolism]; Region: CelB; COG1455 441771009556 Alpha-galactosidases/6-phospho-beta-glucosidases, family 4 of glycosyl hydrolases [Carbohydrate transport and metabolism]; Region: CelF; COG1486 441771009557 Glycoside Hydrolases Family 4; Phospho-beta-glucosidase; Region: GH4_P_beta_glucosidase; cd05296 441771009558 NAD binding site [chemical binding]; other site 441771009559 sugar binding site [chemical binding]; other site 441771009560 divalent metal binding site [ion binding]; other site 441771009561 tetramer (dimer of dimers) interface [polypeptide binding]; other site 441771009562 dimer interface [polypeptide binding]; other site 441771009563 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 441771009564 metal binding site [ion binding]; metal-binding site 441771009565 active site 441771009566 I-site; other site 441771009567 DNA breaking-rejoining enzymes, intergrase/recombinases, C-terminal catalytic domain. The tyrosine recombinase/integrase family share the same catalytic domain containing six conserved active site residues. The best-studied members of this diverse family...; Region: INT_REC_C; cd01182 441771009568 active site 441771009569 catalytic residues [active] 441771009570 DNA binding site [nucleotide binding] 441771009571 Int/Topo IB signature motif; other site 441771009572 S-adenosylmethionine decarboxylase proenzyme, Bacillus form; Region: SAM_DCase_Bsu; TIGR03330 441771009573 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl17173 441771009574 Mor transcription activator family; Region: Mor; cl02360 441771009575 Predicted nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: COG0702 441771009576 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 441771009577 NAD(P) binding site [chemical binding]; other site 441771009578 active site 441771009579 TRAM domain; Region: TRAM; cl01282 441771009580 SAM-dependent methyltransferases related to tRNA (uracil-5-)-methyltransferase [Translation, ribosomal structure and biogenesis]; Region: TrmA; COG2265 441771009581 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 441771009582 S-adenosylmethionine binding site [chemical binding]; other site 441771009583 Domain of Unknown Function (DUF1540); Region: DUF1540; pfam07561 441771009584 Predicted oxidoreductases of the aldo/keto reductase family [General function prediction only]; Region: COG1453 441771009585 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 441771009586 active site 441771009587 catalytic tetrad [active] 441771009588 4Fe-4S dicluster domain; Region: Fer4_17; pfam13534 441771009589 pyruvate kinase; Provisional; Region: PRK06354 441771009590 Pyruvate kinase (PK): Large allosteric enzyme that regulates glycolysis through binding of the substrate, phosphoenolpyruvate, and one or more allosteric effectors. Like other allosteric enzymes, PK has a high substrate affinity R state and a low...; Region: Pyruvate_Kinase; cd00288 441771009591 domain interfaces; other site 441771009592 active site 441771009593 PEP-utilizing enzyme, mobile domain; Region: PEP-utilizers; cl17700 441771009594 6-phosphofructokinase; Provisional; Region: PRK03202 441771009595 active site 441771009596 ADP/pyrophosphate binding site [chemical binding]; other site 441771009597 dimerization interface [polypeptide binding]; other site 441771009598 allosteric effector site; other site 441771009599 fructose-1,6-bisphosphate binding site; other site 441771009600 DNA polymerase III DnaE; Reviewed; Region: dnaE; PRK06826 441771009601 Polymerase and Histidinol Phosphatase domain of alpha-subunit of bacterial polymerase III DnaE3; Region: PHP_PolIIIA_DnaE3; cd12113 441771009602 active site 441771009603 PHP Thumb interface [polypeptide binding]; other site 441771009604 metal binding site [ion binding]; metal-binding site 441771009605 Bacterial DNA polymerase III alpha subunit; Region: DNA_pol3_alpha; pfam07733 441771009606 Helix-hairpin-helix motif; Region: HHH_6; pfam14579 441771009607 DnaE_OBF: A subfamily of OB folds corresponding to the C-terminal OB-fold nucleic acid binding domain of Thermus aquaticus and Escherichia coli type C replicative DNA polymerase III alpha subunit (DnaE). The DNA polymerase holoenzyme of E. coli contains...; Region: DnaE_OBF; cd04485 441771009608 generic binding surface II; other site 441771009609 generic binding surface I; other site 441771009610 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG1481 441771009611 WhiA N-terminal LAGLIDADG-like domain; Region: WhiA_N; pfam10298 441771009612 WhiA LAGLIDADG-like domain; Region: LAGLIDADG_WhiA; pfam14527 441771009613 WhiA C-terminal HTH domain; Region: HTH_WhiA; pfam02650 441771009614 family of mostly uncharacterized proteins similar to B.subtilis YvcK; Region: YvcK_like; cd07187 441771009615 phosphate binding site [ion binding]; other site 441771009616 putative substrate binding pocket [chemical binding]; other site 441771009617 dimer interface [polypeptide binding]; other site 441771009618 glmZ(sRNA)-inactivating NTPase; Provisional; Region: PRK05416 441771009619 UDP-N-acetylenolpyruvoylglucosamine reductase; Provisional; Region: murB; PRK13905 441771009620 FAD binding domain; Region: FAD_binding_4; pfam01565 441771009621 UDP-N-acetylenolpyruvoylglucosamine reductase, C-terminal domain; Region: MurB_C; pfam02873 441771009622 putative hydrolase; Validated; Region: PRK09248 441771009623 Polymerase and Histidinol Phosphatase domain of Ycdx like; Region: PHP_HisPPase_Ycdx_like; cd07437 441771009624 active site 441771009625 excinuclease ABC subunit C; Validated; Region: uvrC; PRK00558 441771009626 Catalytic GIY-YIG domain of nucleotide excision repair endonucleases UvrC, Cho, and similar proteins; Region: GIY-YIG_UvrC_Cho; cd10434 441771009627 GIY-YIG motif/motif A; other site 441771009628 active site 441771009629 catalytic site [active] 441771009630 putative DNA binding site [nucleotide binding]; other site 441771009631 metal binding site [ion binding]; metal-binding site 441771009632 UvrB/uvrC motif; Region: UVR; pfam02151 441771009633 UvrC Helix-hairpin-helix N-terminal; Region: UvrC_HhH_N; pfam08459 441771009634 Helix-hairpin-helix motif; Region: HHH_2; pfam12826 441771009635 Predicted membrane-bound metal-dependent hydrolase (DUF457); Region: DUF457; pfam04307 441771009636 Replication protein A, class 2b aminoacyl-tRNA synthetases, and related proteins with oligonucleotide/oligosaccharide (OB) fold; Region: RPA_2b-aaRSs_OBF_like; cl09930 441771009637 generic binding surface II; other site 441771009638 generic binding surface I; other site 441771009639 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 441771009640 Zn2+ binding site [ion binding]; other site 441771009641 Mg2+ binding site [ion binding]; other site 441771009642 Cell division protein FtsI/penicillin-binding protein 2 [Cell envelope biogenesis, outer membrane]; Region: FtsI; COG0768 441771009643 Penicillin-binding Protein dimerization domain; Region: PBP_dimer; pfam03717 441771009644 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; pfam00905 441771009645 Bacterial cell division membrane protein [Cell division and chromosome partitioning]; Region: FtsW; COG0772 441771009646 Forkhead associated domain (FHA); found in eukaryotic and prokaryotic proteins. Putative nuclear signalling domain. FHA domains may bind phosphothreonine, phosphoserine and sometimes phosphotyrosine. In eukaryotes, many FHA domain-containing proteins...; Region: FHA; cd00060 441771009647 FOG: FHA domain [Signal transduction mechanisms]; Region: COG1716 441771009648 phosphopeptide binding site; other site 441771009649 excinuclease ABC subunit A; Reviewed; Region: uvrA; PRK00349 441771009650 ATP-binding cassette domain I of the excision repair protein UvrA; Region: ABC_UvrA_I; cd03270 441771009651 ATP-binding cassette domain I of the excision repair protein UvrA; Region: ABC_UvrA_I; cd03270 441771009652 ATP-binding cassette domain II of the excision repair protein UvrA; Region: ABC_UvrA_II; cd03271 441771009653 excinuclease ABC subunit B; Provisional; Region: PRK05298 441771009654 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 441771009655 ATP binding site [chemical binding]; other site 441771009656 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 441771009657 putative Mg++ binding site [ion binding]; other site 441771009658 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 441771009659 nucleotide binding region [chemical binding]; other site 441771009660 ATP-binding site [chemical binding]; other site 441771009661 Ultra-violet resistance protein B; Region: UvrB; pfam12344 441771009662 UvrB/uvrC motif; Region: UVR; pfam02151 441771009663 Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain [Posttranslational modification, protein turnover, chaperones]; Region: DegQ; COG0265 441771009664 PDZ domain of trypsin-like serine proteases, such as DegP/HtrA, which are oligomeric proteins involved in heat-shock response, chaperone function, and apoptosis. May be responsible for substrate recognition and/or binding, as most PDZ domains bind...; Region: PDZ_serine_protease; cd00987 441771009665 C-terminal processing peptidase; serine protease family S41; Region: Peptidase_S41_CPP; cd07560 441771009666 C-terminal peptidase (prc); Region: prc; TIGR00225 441771009667 PDZ domain of C-terminal processing-, tail-specific-, and tricorn proteases, which function in posttranslational protein processing, maturation, and disassembly or degradation, in Bacteria, Archaea, and plant chloroplasts. May be responsible for...; Region: PDZ_CTP_protease; cd00988 441771009668 protein binding site [polypeptide binding]; other site 441771009669 Catalytic dyad [active] 441771009670 Cell division protein [Cell division and chromosome partitioning]; Region: FtsX; COG2177 441771009671 cell division ABC transporter subunit FtsX; Provisional; Region: ftsX; PRK11026 441771009672 FtsX-like permease family; Region: FtsX; pfam02687 441771009673 Predicted ATPase involved in cell division [Cell division and chromosome partitioning]; Region: FtsE; COG2884 441771009674 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 441771009675 Walker A/P-loop; other site 441771009676 ATP binding site [chemical binding]; other site 441771009677 Q-loop/lid; other site 441771009678 ABC transporter signature motif; other site 441771009679 Walker B; other site 441771009680 D-loop; other site 441771009681 H-loop/switch region; other site 441771009682 Uncharacterized conserved protein [Function unknown]; Region: COG1284 441771009683 Uncharacterized BCR, YitT family COG1284; Region: DUF161; pfam02588 441771009684 Uncharacterized BCR, YitT family COG1284; Region: DUF161; pfam02588 441771009685 Uncharacterized protein conserved in bacteria (DUF2179); Region: DUF2179; pfam10035 441771009686 Transketolase, C-terminal subunit [Carbohydrate transport and metabolism]; Region: COG3958 441771009687 Pyrimidine (PYR) binding domain of 1-deoxy-D-xylulose-5-phosphate synthase (DXS), transketolase (TK), and related proteins; Region: TPP_PYR_DXS_TK_like; cd07033 441771009688 PYR/PP interface [polypeptide binding]; other site 441771009689 dimer interface [polypeptide binding]; other site 441771009690 TPP binding site [chemical binding]; other site 441771009691 Transketolase, C-terminal domain; Region: Transketolase_C; pfam02780 441771009692 Thiamine pyrophosphate (TPP) family, Transketolase (TK) subfamily, TPP-binding module; TK catalyzes the transfer of a two-carbon unit from ketose phosphates to aldose phosphates. In heterotrophic organisms, TK provides a link between glycolysis and the...; Region: TPP_TK; cd02012 441771009693 TPP-binding site [chemical binding]; other site 441771009694 dimer interface [polypeptide binding]; other site 441771009695 PemK-like protein; Region: PemK; pfam02452 441771009696 Predicted transcriptional regulators containing the CopG/Arc/MetJ DNA-binding domain and a metal-binding domain [Transcription]; Region: NikR; COG0864 441771009697 alanine racemase; Reviewed; Region: alr; PRK00053 441771009698 Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzyme Alanine Racemase; Region: PLPDE_III_AR; cd00430 441771009699 active site 441771009700 pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site 441771009701 dimer interface [polypeptide binding]; other site 441771009702 substrate binding site [chemical binding]; other site 441771009703 catalytic residues [active] 441771009704 Outer membrane lipoprotein carrier protein LolA; Region: LolA; cl19192 441771009705 YjeF-related protein N-terminus; Region: YjeF_N; pfam03853 441771009706 B.subtilis YXKO protein of unknown function and related proteins. Based on the conservation of the ATP binding site, the substrate binding site and the Mg2+binding site and structural homology this group is a member of the ribokinase-like superfamily; Region: YXKO-related; cd01171 441771009707 putative substrate binding site [chemical binding]; other site 441771009708 putative ATP binding site [chemical binding]; other site 441771009709 4'-phosphopantetheinyl transferase; Provisional; Region: acpS; PRK00070 441771009710 Na+/H+ antiporter [Energy production and conversion]; Region: NhaC; COG1757 441771009711 Anion permease ArsB/NhaD. These permeases have been shown to translocate sodium, arsenate, antimonite, sulfate and organic anions across biological membranes in all three kingdoms of life. A typical anion permease contains 8-13 transmembrane helices...; Region: ArsB_NhaD_permease; cl17221 441771009712 Na+/H+ antiporter family; Region: Na_H_antiporter; pfam03553 441771009713 Virulence factor BrkB; Region: Virul_fac_BrkB; pfam03631 441771009714 30S ribosomal protein S4; Validated; Region: rpsD; PRK05327 441771009715 Ribosomal protein S4/S9 N-terminal domain; Region: Ribosomal_S4; pfam00163 441771009716 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 441771009717 RNA binding surface [nucleotide binding]; other site 441771009718 Sodium:dicarboxylate symporter family; Region: SDF; pfam00375 441771009719 Membrane-associated phospholipid phosphatase [Lipid metabolism]; Region: PgpB; COG0671 441771009720 PAP2_like proteins, a super-family of histidine phosphatases and vanadium haloperoxidases, includes type 2 phosphatidic acid phosphatase or lipid phosphate phosphatase (LPP), Glucose-6-phosphatase, Phosphatidylglycerophosphatase B and bacterial acid...; Region: PAP2_like; cl00474 441771009721 active site 441771009722 Ferritin-like superfamily of diiron-containing four-helix-bundle proteins; Region: Ferritin_like; cd00657 441771009723 dinuclear metal binding motif [ion binding]; other site 441771009724 glucosamine--fructose-6-phosphate aminotransferase; Reviewed; Region: PRK00331 441771009725 Glutamine amidotransferases class-II (Gn-AT)_GFAT-type. This domain is found at the N-terminus of glucosamine-6P synthase (GlmS, or GFAT in humans). The glutaminase domain catalyzes amide nitrogen transfer from glutamine to the appropriate substrate. In...; Region: GFAT; cd00714 441771009726 glutaminase active site [active] 441771009727 SIS (Sugar ISomerase) domain repeat 1 found in Glucosamine 6-phosphate synthase (GlmS) and Glucosamine-6-phosphate deaminase (GlmD). The SIS domain is found in many phosphosugar isomerases and phosphosugar binding proteins. GlmS contains a N-terminal...; Region: SIS_GlmS_GlmD_1; cd05008 441771009728 dimer interface [polypeptide binding]; other site 441771009729 active site 441771009730 SIS (Sugar ISomerase) domain repeat 2 found in Glucosamine 6-phosphate synthase (GlmS) and Glucosamine-6-phosphate deaminase (GlmD). The SIS domain is found in many phosphosugar isomerases and phosphosugar binding proteins. GlmS contains a N-terminal...; Region: SIS_GlmS_GlmD_2; cd05009 441771009731 dimer interface [polypeptide binding]; other site 441771009732 active site 441771009733 Transaldolase-like fructose-6-phosphate aldolases (FSA) found in bacteria and archaea; Region: Transaldolase_FSA; cd00956 441771009734 active site 441771009735 intersubunit interactions; other site 441771009736 catalytic residue [active] 441771009737 beta-phosphoglucomutase family hydrolase; Region: PGMB-YQAB-SF; TIGR02009 441771009738 haloacid dehalogenase-like hydrolase; Region: HAD; pfam12710 441771009739 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 441771009740 motif II; other site 441771009741 sorbitol-6-phosphate dehydrogenase; Provisional; Region: PRK12384 441771009742 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 441771009743 NAD(P) binding site [chemical binding]; other site 441771009744 active site 441771009745 PTS system glucitol/sorbitol-specific IIA component; Region: PTSIIA_gutA; pfam03829 441771009746 Phosphotransferase system sorbitol-specific component IIBC [Carbohydrate transport and metabolism]; Region: SrlE; COG3732 441771009747 Sorbitol phosphotransferase enzyme II N-terminus; Region: EIIBC-GUT_N; pfam03612 441771009748 Nucleoside recognition; Region: Gate; pfam07670 441771009749 Sorbitol phosphotransferase enzyme II C-terminus; Region: EIIBC-GUT_C; pfam07663 441771009750 PTS system enzyme II sorbitol-specific factor; Region: EII-GUT; pfam03608 441771009751 Glucitol operon activator protein (GutM); Region: GutM; pfam06923 441771009752 Threonine dehydrogenase and related Zn-dependent dehydrogenases [Amino acid transport and metabolism / General function prediction only]; Region: Tdh; COG1063 441771009753 NAD(P)-dependent sugar dehydrogenases; Region: sugar_DH; cd08236 441771009754 putative NAD(P) binding site [chemical binding]; other site 441771009755 catalytic Zn binding site [ion binding]; other site 441771009756 Transcriptional regulator, contains sigma factor-related N-terminal domain [Transcription]; Region: DeoR; COG2390 441771009757 helix_turn_helix, cAMP Regulatory protein; Region: HTH_CRP; smart00419 441771009758 non-specific DNA interactions [nucleotide binding]; other site 441771009759 DNA binding site [nucleotide binding] 441771009760 sequence specific DNA binding site [nucleotide binding]; other site 441771009761 putative cAMP binding site [chemical binding]; other site 441771009762 Putative sugar-binding domain; Region: Sugar-bind; pfam04198 441771009763 phosphoglucosamine mutase; Provisional; Region: glmM; PRK14316 441771009764 GlmM is a bacterial phosphoglucosamine mutase (PNGM) that belongs to the alpha-D-phosphohexomutase superfamily. It is required for the interconversion of glucosamine-6-phosphate and glucosamine-1-phosphate in the biosynthetic pathway of...; Region: GlmM; cd05802 441771009765 active site 441771009766 substrate binding site [chemical binding]; other site 441771009767 metal binding site [ion binding]; metal-binding site 441771009768 Pyruvate ferredoxin/flavodoxin oxidoreductase; Region: POR; pfam01558 441771009769 Pyruvate:ferredoxin oxidoreductase and related 2-oxoacid:ferredoxin oxidoreductases, beta subunit [Energy production and conversion]; Region: PorB; COG1013 441771009770 Thiamine pyrophosphate (TPP) enzyme family, TPP-binding module; found in many key metabolic enzymes which use TPP (also known as thiamine diphosphate) as a cofactor. These enzymes include, among others, the E1 components of the pyruvate, the acetoin and...; Region: TPP_enzymes; cl01629 441771009771 TPP-binding site [chemical binding]; other site 441771009772 2-ketoisovalerate ferredoxin reductase; Validated; Region: PRK07119 441771009773 Pyrimidine (PYR) binding domain of pyruvate ferredoxin oxidoreductase (PFOR), indolepyruvate ferredoxin oxidoreductase alpha subunit (IOR-alpha), and related proteins; Region: TPP_PYR_PFOR_IOR-alpha_like; cd07034 441771009774 dimer interface [polypeptide binding]; other site 441771009775 PYR/PP interface [polypeptide binding]; other site 441771009776 TPP binding site [chemical binding]; other site 441771009777 substrate binding site [chemical binding]; other site 441771009778 Transketolase, C-terminal domain; Region: Transketolase_C; pfam02780 441771009779 The HCP family of iron-sulfur proteins includes hybrid cluster protein (HCP), acetyl-CoA synthase (ACS), and carbon monoxide dehydrogenase (CODH), all of which contain [Fe4-S4] metal clusters at their active sites. These proteins have a conserved...; Region: HCP_like; cl19102 441771009780 4Fe-4S dicluster domain; Region: Fer4_7; pfam12838 441771009781 RecA-like NTPases. This family includes the NTP binding domain of F1 and V1 H+ATPases, DnaB and related helicases as well as bacterial RecA and related eukaryotic and archaeal recombinases. This group also includes bacterial conjugation proteins and...; Region: RecA-like_NTPases; cl17233 441771009782 Walker A motif; other site 441771009783 ATP binding site [chemical binding]; other site 441771009784 ParA and ParB of Caulobacter crescentus belong to a conserved family of bacterial proteins implicated in chromosome segregation. ParB binds to DNA sequences adjacent to the origin of replication and localizes to opposite cell poles shortly following the...; Region: ParA; cd02042 441771009785 P-loop; other site 441771009786 Magnesium ion binding site [ion binding]; other site 441771009787 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cd00012 441771009788 nucleotide binding site [chemical binding]; other site 441771009789 Acetokinase family; Region: Acetate_kinase; cl17229 441771009790 phosphate butyryltransferase; Validated; Region: PRK05805 441771009791 butyrate kinase; Provisional; Region: PRK03011 441771009792 Transcriptional regulator/sugar kinase [Transcription / Carbohydrate transport and metabolism]; Region: NagC; COG1940 441771009793 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl19134 441771009794 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4856 441771009795 YbbR-like protein; Region: YbbR; pfam07949 441771009796 Uncharacterized conserved protein [Function unknown]; Region: COG1624 441771009797 DisA bacterial checkpoint controller nucleotide-binding; Region: DisA_N; pfam02457 441771009798 Cell Wall Hydrolase; Region: Hydrolase_2; pfam07486 441771009799 Thioredoxin reductase [Posttranslational modification, protein turnover, chaperones]; Region: TrxB; COG0492 441771009800 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl19134 441771009801 Type III secretion system protein PrgH-EprH (PrgH); Region: PrgH; cl12363 441771009802 TRX family; composed of two groups: Group I, which includes proteins that exclusively encode a TRX domain; and Group II, which are composed of fusion proteins of TRX and additional domains. Group I TRX is a small ancient protein that alter the redox...; Region: TRX_family; cd02947 441771009803 catalytic residues [active] 441771009804 isoaspartyl dipeptidase; Provisional; Region: PRK10657 441771009805 Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281 441771009806 active site 441771009807 TPR repeat; Region: TPR_11; pfam13414 441771009808 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 441771009809 binding surface 441771009810 TPR motif; other site 441771009811 Domain of unknown function (DUF4652); Region: DUF4652; pfam15525 441771009812 Phosphoenolpyruvate-protein kinase (PTS system EI component in bacteria) [Carbohydrate transport and metabolism]; Region: PtsA; COG1080 441771009813 PEP-utilizing enzyme, N-terminal; Region: PEP-utilizers_N; pfam05524 441771009814 PEP-utilizing enzyme, mobile domain; Region: PEP-utilizers; pfam00391 441771009815 PEP-utilizing enzyme, TIM barrel domain; Region: PEP-utilizers_C; pfam02896 441771009816 Histidine-containing phosphocarrier protein (HPr)-like proteins. HPr is a central component of the bacterial phosphoenolpyruvate sugar phosphotransferase system (PTS). The PTS catalyses the phosphorylation of sugar substrates during their translocation...; Region: PTS-HPr_like; cd00367 441771009817 dimerization domain swap beta strand [polypeptide binding]; other site 441771009818 regulatory protein interface [polypeptide binding]; other site 441771009819 active site 441771009820 regulatory phosphorylation site [posttranslational modification]; other site 441771009821 Transcriptional regulator containing PAS, AAA-type ATPase, and DNA-binding domains [Transcription / Signal transduction mechanisms]; Region: RocR; COG3829 441771009822 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 441771009823 putative active site [active] 441771009824 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 441771009825 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 441771009826 Walker A motif; other site 441771009827 ATP binding site [chemical binding]; other site 441771009828 Walker B motif; other site 441771009829 arginine finger; other site 441771009830 Bacterial regulatory protein, Fis family; Region: HTH_8; cl17420 441771009831 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 441771009832 binding surface 441771009833 TPR motif; other site 441771009834 TPR repeat; Region: TPR_11; pfam13414 441771009835 TPR repeat; Region: TPR_11; pfam13414 441771009836 fumarate hydratase; Provisional; Region: PRK06842 441771009837 fumarate hydratase; Provisional; Region: PRK06246 441771009838 N-acetylmuramoyl-L-alanine amidase [Cell envelope biogenesis, outer membrane]; Region: AmiC; COG0860 441771009839 N-acetylmuramoyl-L-alanine amidase or MurNAc-LAA (also known as peptidoglycan aminohydrolase, NAMLA amidase, NAMLAA, Amidase 3, and peptidoglycan amidase; EC 3.5.1.28) is an autolysin that hydrolyzes the amide bond between N-acetylmuramoyl and L-amino...; Region: MurNAc-LAA; cd02696 441771009840 active site 441771009841 metal binding site [ion binding]; metal-binding site 441771009842 Na+/phosphate symporter [Inorganic ion transport and metabolism]; Region: NptA; COG1283 441771009843 Na+/Pi-cotransporter; Region: Na_Pi_cotrans; pfam02690 441771009844 Na+/Pi-cotransporter; Region: Na_Pi_cotrans; pfam02690 441771009845 PhoU domain; Region: PhoU; pfam01895 441771009846 PhoU domain; Region: PhoU; pfam01895 441771009847 30S ribosomal protein S9; Reviewed; Region: rpsI; PRK00132 441771009848 Ribosomal protein L13. Protein L13, a large ribosomal subunit protein, is one of five proteins required for an early folding intermediate of 23S rRNA in the assembly of the large subunit. L13 is situated on the bottom of the large subunit, near the...; Region: Ribosomal_L13; cd00392 441771009849 23S rRNA interface [nucleotide binding]; other site 441771009850 L3 interface [polypeptide binding]; other site 441771009851 tRNA pseudouridine synthase A; Validated; Region: truA; PRK00021 441771009852 Eukaryotic and bacterial pseudouridine synthases similar to E. coli TruA; Region: PseudoU_synth_EcTruA; cd02570 441771009853 dimerization interface 3.5A [polypeptide binding]; other site 441771009854 active site 441771009855 ABC-type cobalt transport system, permease component CbiQ and related transporters [Inorganic ion transport and metabolism]; Region: CbiQ; COG0619 441771009856 cobalt transporter ATP-binding subunit; Provisional; Region: cbiO; PRK13637 441771009857 First domain of the ATP-binding cassette component of cobalt transport system; Region: ABC_cobalt_CbiO_domain1; cd03225 441771009858 Walker A/P-loop; other site 441771009859 ATP binding site [chemical binding]; other site 441771009860 Q-loop/lid; other site 441771009861 ABC transporter signature motif; other site 441771009862 Walker B; other site 441771009863 D-loop; other site 441771009864 H-loop/switch region; other site 441771009865 cobalt transporter ATP-binding subunit; Provisional; Region: PRK13633 441771009866 First domain of the ATP-binding cassette component of cobalt transport system; Region: ABC_cobalt_CbiO_domain1; cd03225 441771009867 Walker A/P-loop; other site 441771009868 ATP binding site [chemical binding]; other site 441771009869 Q-loop/lid; other site 441771009870 ABC transporter signature motif; other site 441771009871 Walker B; other site 441771009872 D-loop; other site 441771009873 H-loop/switch region; other site 441771009874 50S ribosomal protein L17; Validated; Region: rplQ; PRK05591 441771009875 DNA-directed RNA polymerase subunit alpha; Provisional; Region: PRK05182 441771009876 N-terminal domain of the Alpha subunit of Bacterial RNA polymerase; Region: RNAP_alpha_NTD; cd06928 441771009877 alphaNTD homodimer interface [polypeptide binding]; other site 441771009878 alphaNTD - beta interaction site [polypeptide binding]; other site 441771009879 alphaNTD - beta' interaction site [polypeptide binding]; other site 441771009880 Bacterial RNA polymerase, alpha chain C terminal domain; Region: RNA_pol_A_CTD; pfam03118 441771009881 30S ribosomal protein S4; Validated; Region: rpsD; PRK05327 441771009882 Ribosomal protein S4/S9 N-terminal domain; Region: Ribosomal_S4; pfam00163 441771009883 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 441771009884 RNA binding surface [nucleotide binding]; other site 441771009885 30S ribosomal protein S11; Validated; Region: PRK05309 441771009886 30S ribosomal protein S13; Validated; Region: rpsM; PRK05179 441771009887 50S ribosomal protein L36; Reviewed; Region: rpmJ; PRK00465 441771009888 S1_IF1: Translation Initiation Factor IF1, S1-like RNA-binding domain. IF1 contains an S1-like RNA-binding domain, which is found in a wide variety of RNA-associated proteins. Translation initiation includes a number of interrelated steps preceding the...; Region: S1_IF1; cd04451 441771009889 rRNA binding site [nucleotide binding]; other site 441771009890 predicted 30S ribosome binding site; other site 441771009891 KOW motif of Ribosomal Protein L14; Region: KOW_RPL14; cd06088 441771009892 RNA binding site [nucleotide binding]; other site 441771009893 Methionine Aminopeptidase 1. E.C. 3.4.11.18. Also known as methionyl aminopeptidase and Peptidase M. Catalyzes release of N-terminal amino acids, preferentially methionine, from peptides and arylamides; Region: MetAP1; cd01086 441771009894 active site 441771009895 adenylate kinase; Reviewed; Region: adk; PRK00279 441771009896 Adenylate kinase (ADK) catalyzes the reversible phosphoryl transfer from adenosine triphosphates (ATP) to adenosine monophosphates (AMP) and to yield adenosine diphosphates (ADP). This enzyme is required for the biosynthesis of ADP and is essential for...; Region: ADK; cd01428 441771009897 AMP-binding site [chemical binding]; other site 441771009898 ATP-AMP (Ap5A)-binding site [chemical binding]; other site 441771009899 preprotein translocase subunit SecY; Reviewed; Region: secY; PRK09204 441771009900 SecY translocase; Region: SecY; pfam00344 441771009901 50S ribosomal protein L15; Reviewed; Region: rplO; PRK05592 441771009902 Ribosomal protein L30, which is found in eukaryotes and prokaryotes but not in archaea, is one of the smallest ribosomal proteins with a molecular mass of about 7kDa. L30 binds the 23SrRNA as well as the 5S rRNA and is one of five ribosomal proteins that...; Region: Ribosomal_L30; cd01658 441771009903 23S rRNA binding site [nucleotide binding]; other site 441771009904 30S ribosomal protein S5; Validated; Region: rpsE; PRK00550 441771009905 Ribosomal protein S5, N-terminal domain; Region: Ribosomal_S5; pfam00333 441771009906 Ribosomal protein S5, C-terminal domain; Region: Ribosomal_S5_C; pfam03719 441771009907 Ribosomal L18/L5e: L18 (L5e) is a ribosomal protein found in the central protuberance (CP) of the large subunit. L18 binds 5S rRNA and induces a conformational change that stimulates the binding of L5 to 5S rRNA. Association of 5S rRNA with 23S rRNA...; Region: Ribosomal_L18_L5e; cd00432 441771009908 5S rRNA interface [nucleotide binding]; other site 441771009909 L27 interface [polypeptide binding]; other site 441771009910 23S rRNA interface [nucleotide binding]; other site 441771009911 L5 interface [polypeptide binding]; other site 441771009912 50S ribosomal protein L6; Validated; Region: rplF; PRK05498 441771009913 Ribosomal protein L6; Region: Ribosomal_L6; pfam00347 441771009914 Ribosomal protein L6; Region: Ribosomal_L6; pfam00347 441771009915 30S ribosomal protein S8; Validated; Region: rpsH; PRK00136 441771009916 30S ribosomal protein S14; Reviewed; Region: rpsN; PRK08061 441771009917 50S ribosomal protein L5; Validated; Region: rplE; PRK00010 441771009918 Ribosomal protein L5; Region: Ribosomal_L5; pfam00281 441771009919 ribosomal L5P family C-terminus; Region: Ribosomal_L5_C; pfam00673 441771009920 KOW motif of Ribosomal Protein L26; Region: KOW_RPL26; cd06089 441771009921 RNA binding site [nucleotide binding]; other site 441771009922 zinc-ribbon domain; Region: zinc_ribbon_5; cl11777 441771009923 50S ribosomal protein L14; Validated; Region: rplN; PRK05483 441771009924 30S ribosomal protein S17; Reviewed; Region: rpsQ; PRK05610 441771009925 Ribosomal L29 protein/HIP. L29 is a protein of the large ribosomal Subunit. A homolog, called heparin/heparan sulfate interacting protein (HIP), has also been identified in mammals. L29 is located on the surface of the large ribosomal subunit, where it...; Region: Ribosomal_L29_HIP; cd00427 441771009926 23S rRNA interface [nucleotide binding]; other site 441771009927 putative translocon interaction site; other site 441771009928 signal recognition particle (SRP54) interaction site; other site 441771009929 L23 interface [polypeptide binding]; other site 441771009930 trigger factor interaction site; other site 441771009931 Ribosomal_L16_L10e: L16 is an essential protein in the large ribosomal subunit of bacteria, mitochondria, and chloroplasts. Large subunits that lack L16 are defective in peptidyl transferase activity, peptidyl-tRNA hydrolysis activity, association with...; Region: Ribosomal_L16_L10e; cd01433 441771009932 23S rRNA interface [nucleotide binding]; other site 441771009933 5S rRNA interface [nucleotide binding]; other site 441771009934 putative antibiotic binding site [chemical binding]; other site 441771009935 L25 interface [polypeptide binding]; other site 441771009936 L27 interface [polypeptide binding]; other site 441771009937 30S ribosomal protein S3; Reviewed; Region: rpsC; PRK00310 441771009938 K homology RNA-binding (KH) domain of the prokaryotic 30S small ribosomal subunit protein S3. S3 is part of the head region of the 30S ribosomal subunit and is believed to interact with mRNA as it threads its way from the latch into the channel. The KH...; Region: 30S_S3_KH; cd02412 441771009939 G-X-X-G motif; other site 441771009940 Ribosomal protein S3, C-terminal domain; Region: Ribosomal_S3_C; pfam00189 441771009941 Ribosomal protein L22/L17e. L22 (L17 in eukaryotes) is a core protein of the large ribosomal subunit. It is the only ribosomal protein that interacts with all six domains of 23S rRNA, and is one of the proteins important for directing the proper...; Region: Ribosomal_L22; cd00336 441771009942 putative translocon binding site; other site 441771009943 protein-rRNA interface [nucleotide binding]; other site 441771009944 30S ribosomal protein S19; Reviewed; Region: rpsS; PRK00357 441771009945 50S ribosomal protein L2; Validated; Region: rplB; PRK09374 441771009946 Ribosomal Proteins L2, RNA binding domain; Region: Ribosomal_L2; pfam00181 441771009947 Ribosomal Proteins L2, C-terminal domain; Region: Ribosomal_L2_C; pfam03947 441771009948 50S ribosomal protein L23; Reviewed; Region: rplW; PRK05738 441771009949 50S ribosomal protein L4; Provisional; Region: rplD; PRK05319 441771009950 50S ribosomal protein L3; Validated; Region: rplC; PRK00001 441771009951 30S ribosomal protein S10; Reviewed; Region: rpsJ; PRK00596 441771009952 elongation factor Tu; Reviewed; Region: PRK00049 441771009953 Elongation Factor Tu (EF-Tu) GTP-binding proteins; Region: EF_Tu; cd01884 441771009954 G1 box; other site 441771009955 GEF interaction site [polypeptide binding]; other site 441771009956 GTP/Mg2+ binding site [chemical binding]; other site 441771009957 Switch I region; other site 441771009958 G2 box; other site 441771009959 G3 box; other site 441771009960 Switch II region; other site 441771009961 G4 box; other site 441771009962 G5 box; other site 441771009963 EFTU_II: Elongation factor Tu domain II. Elongation factors Tu (EF-Tu) are three-domain GTPases with an essential function in the elongation phase of mRNA translation. The GTPase center of EF-Tu is in the N-terminal domain (domain I), also known as the...; Region: EFTU_II; cd03697 441771009964 Domain III of elongation factor (EF) Tu. Ef-Tu consists of three structural domains, designated I, II and III. Domain III adopts a beta barrel structure. Domain III is involved in binding to both charged tRNA and binding to elongation factor Ts (EF-Ts); Region: EFTU_III; cd03707 441771009965 Antibiotic Binding Site [chemical binding]; other site 441771009966 elongation factor G; Reviewed; Region: PRK00007 441771009967 Elongation factor G (EF-G) family involved in both the elongation and ribosome recycling phases of protein synthesis; Region: EF-G; cd01886 441771009968 G1 box; other site 441771009969 putative GEF interaction site [polypeptide binding]; other site 441771009970 GTP/Mg2+ binding site [chemical binding]; other site 441771009971 Switch I region; other site 441771009972 G2 box; other site 441771009973 G3 box; other site 441771009974 Switch II region; other site 441771009975 G4 box; other site 441771009976 G5 box; other site 441771009977 EFG_mtEFG_II: this subfamily represents the domain II of elongation factor G (EF-G) in bacteria and, the C-terminus of mitochondrial Elongation factor G1 (mtEFG1) and G2 (mtEFG2)_like proteins found in eukaryotes. During the process of peptide synthesis...; Region: EFG_mtEFG_II; cd04088 441771009978 Elongation Factor G, domain II; Region: EFG_II; pfam14492 441771009979 EFG_mtEFG1_IV: domains similar to domain IV of the bacterial translational elongation factor (EF) EF-G. Included in this group is a domain of mitochondrial Elongation factor G1 (mtEFG1) proteins homologous to domain IV of EF-G. Eukaryotic cells harbor 2...; Region: EFG_mtEFG1_IV; cd01434 441771009980 EFG_mtEFG_C: domains similar to the C-terminal domain of the bacterial translational elongation factor (EF) EF-G. Included in this group is the C-terminus of mitochondrial Elongation factor G1 (mtEFG1) and G2 (mtEFG2) proteins. Eukaryotic cells harbor 2...; Region: EFG_mtEFG_C; cd03713 441771009981 30S ribosomal protein S7; Validated; Region: PRK05302 441771009982 S12-like family, 30S ribosomal protein S12 subfamily; S12 is located at the interface of the large and small ribosomal subunits of prokaryotes, chloroplasts and mitochondria, where it plays an important role in both tRNA and ribosomal subunit...; Region: Ribosomal_S12; cd03368 441771009983 S17 interaction site [polypeptide binding]; other site 441771009984 S8 interaction site; other site 441771009985 16S rRNA interaction site [nucleotide binding]; other site 441771009986 streptomycin interaction site [chemical binding]; other site 441771009987 23S rRNA interaction site [nucleotide binding]; other site 441771009988 aminoacyl-tRNA interaction site (A-site) [nucleotide binding]; other site 441771009989 Ribosomal protein L7Ae/L30e/S12e/Gadd45 family; Region: Ribosomal_L7Ae; cl00600 441771009990 DNA-directed RNA polymerase subunit beta'; Provisional; Region: PRK00566 441771009991 Largest subunit (beta') of bacterial DNA-dependent RNA polymerase (RNAP), N-terminal domain; Region: RNAP_beta'_N; cd01609 441771009992 beta and beta' interface [polypeptide binding]; other site 441771009993 beta' and sigma factor interface [polypeptide binding]; other site 441771009994 Zn-binding [ion binding]; other site 441771009995 active site region [active] 441771009996 catalytic site [active] 441771009997 Largest subunit (beta') of Bacterial DNA-dependent RNA polymerase (RNAP), C-terminal domain; Region: RNAP_beta'_C; cd02655 441771009998 Rpb1 (beta') - Rpb6 (omega) interaction site [polypeptide binding]; other site 441771009999 Rpb1 (beta') - Rpb2 (beta) interaction site [polypeptide binding]; other site 441771010000 G-loop; other site 441771010001 DNA binding site [nucleotide binding] 441771010002 Apocytochrome F, C-terminal; Region: Apocytochr_F_C; cl03168 441771010003 DNA-directed RNA polymerase subunit beta; Reviewed; Region: rpoB; PRK00405 441771010004 RNA polymerase beta subunit. RNA polymerases catalyse the DNA dependent polymerization of RNA. Prokaryotes contain a single RNA polymerase compared to three in eukaryotes (not including mitochondrial. and chloroplast polymerases). Each RNA polymerase...; Region: RNA_pol_B_RPB2; cd00653 441771010005 RPB12 interaction site [polypeptide binding]; other site 441771010006 RNA polymerase beta subunit; Region: RNA_pol_Rpb2_1; cl19478 441771010007 RPB1 interaction site [polypeptide binding]; other site 441771010008 RNA polymerase beta subunit external 1 domain; Region: RNA_pol_Rpb2_45; pfam10385 441771010009 RPB10 interaction site [polypeptide binding]; other site 441771010010 RPB11 interaction site [polypeptide binding]; other site 441771010011 RPB3 interaction site [polypeptide binding]; other site 441771010012 Ribosomal protein L7/L12. Ribosomal protein L7/L12 refers to the large ribosomal subunit proteins L7 and L12, which are identical except that L7 is acetylated at the N terminus. It is a component of the L7/L12 stalk, which is located at the surface of...; Region: Ribosomal_L7_L12; cd00387 441771010013 core dimer interface [polypeptide binding]; other site 441771010014 peripheral dimer interface [polypeptide binding]; other site 441771010015 L10 interface [polypeptide binding]; other site 441771010016 L11 interface [polypeptide binding]; other site 441771010017 putative EF-Tu interaction site [polypeptide binding]; other site 441771010018 putative EF-G interaction site [polypeptide binding]; other site 441771010019 Ribosomal protein L10 family, L10 subfamily; composed of bacterial 50S ribosomal protein and eukaryotic mitochondrial 39S ribosomal protein, L10. L10 occupies the L7/L12 stalk of the ribosome. The N-terminal domain (NTD) of L10 interacts with L11 protein...; Region: Ribosomal_L10; cd05797 441771010020 23S rRNA interface [nucleotide binding]; other site 441771010021 Interface with L7/L12 ribosomal proteins [polypeptide binding]; other site 441771010022 Ribosomal protein L1. The L1 protein, located near the E-site of the ribosome, forms part of the L1 stalk along with 23S rRNA. In bacteria and archaea, L1 functions both as a ribosomal protein that binds rRNA, and as a translation repressor that binds...; Region: Ribosomal_L1; cd00403 441771010023 mRNA/rRNA interface [nucleotide binding]; other site 441771010024 50S ribosomal protein L11; Validated; Region: rplK; PRK00140 441771010025 Ribosomal protein L11. Ribosomal protein L11, together with proteins L10 and L7/L12, and 23S rRNA, form the L7/L12 stalk on the surface of the large subunit of the ribosome. The homologous eukaryotic cytoplasmic protein is also called 60S ribosomal...; Region: Ribosomal_L11; cd00349 441771010026 23S rRNA interface [nucleotide binding]; other site 441771010027 L7/L12 interface [polypeptide binding]; other site 441771010028 putative thiostrepton binding site; other site 441771010029 L25 interface [polypeptide binding]; other site 441771010030 transcription antitermination protein NusG; Validated; Region: nusG; PRK05609 441771010031 Bacterial N-Utilization Substance G (NusG) N-terminal (NGN) domain, subgroup 1; Region: NGN_Bact_1; cd09891 441771010032 putative homodimer interface [polypeptide binding]; other site 441771010033 NusG contains an NGN domain at its N-terminus and KOW motif at its C-terminus; Region: KOW_NusG; cd06091 441771010034 heterodimer interface [polypeptide binding]; other site 441771010035 homodimer interface [polypeptide binding]; other site 441771010036 SecE/Sec61-gamma subunits of protein translocation complex; Region: SecE; pfam00584 441771010037 50S ribosomal protein L33; Validated; Region: rpmG; PRK00504 441771010038 elongation factor Tu; Reviewed; Region: PRK00049 441771010039 Elongation Factor Tu (EF-Tu) GTP-binding proteins; Region: EF_Tu; cd01884 441771010040 G1 box; other site 441771010041 GEF interaction site [polypeptide binding]; other site 441771010042 GTP/Mg2+ binding site [chemical binding]; other site 441771010043 Switch I region; other site 441771010044 G2 box; other site 441771010045 G3 box; other site 441771010046 Switch II region; other site 441771010047 G4 box; other site 441771010048 G5 box; other site 441771010049 EFTU_II: Elongation factor Tu domain II. Elongation factors Tu (EF-Tu) are three-domain GTPases with an essential function in the elongation phase of mRNA translation. The GTPase center of EF-Tu is in the N-terminal domain (domain I), also known as the...; Region: EFTU_II; cd03697 441771010050 Domain III of elongation factor (EF) Tu. Ef-Tu consists of three structural domains, designated I, II and III. Domain III adopts a beta barrel structure. Domain III is involved in binding to both charged tRNA and binding to elongation factor Ts (EF-Ts); Region: EFTU_III; cd03707 441771010051 Antibiotic Binding Site [chemical binding]; other site 441771010052 RNA polymerase factor sigma-70; Validated; Region: PRK08295 441771010053 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 441771010054 Sigma-70, region 4; Region: Sigma70_r4_2; pfam08281 441771010055 YacP-like NYN domain; Region: NYN_YacP; pfam05991 441771010056 rRNA methylases [Translation, ribosomal structure and biogenesis]; Region: SpoU; COG0566 441771010057 RNA 2'-O ribose methyltransferase substrate binding; Region: SpoU_sub_bind; pfam08032 441771010058 SpoU rRNA Methylase family; Region: SpoU_methylase; pfam00588 441771010059 FAD-dependent thymidylate synthase; Reviewed; Region: thyX; PRK00847 441771010060 Ribonuclease III family protein [Replication, recombination, and repair]; Region: COG1939 441771010061 dimerization interface [polypeptide binding]; other site 441771010062 active site 441771010063 metal binding site [ion binding]; metal-binding site 441771010064 cysteinyl-tRNA synthetase; Validated; Region: cysS; PRK00260 441771010065 catalytic core domain of cysteinyl tRNA synthetase; Region: CysRS_core; cd00672 441771010066 active site 441771010067 HIGH motif; other site 441771010068 KMSKS motif; other site 441771010069 Anticodon-binding domain of class Ia aminoacyl tRNA synthetases and similar domains; Region: Anticodon_Ia_like; cl12020 441771010070 tRNA binding surface [nucleotide binding]; other site 441771010071 anticodon binding site; other site 441771010072 threonine dehydratase; Provisional; Region: PRK08198 441771010073 Threonine dehydratase: The first step in amino acid degradation is the removal of nitrogen. Although the nitrogen atoms of most amino acids are transferred to alpha-ketoglutarate before removal, the alpha-amino group of threonine can be directly...; Region: Thr-dehyd; cd01562 441771010074 tetramer interface [polypeptide binding]; other site 441771010075 pyridoxal 5'-phosphate binding site [chemical binding]; other site 441771010076 catalytic residue [active] 441771010077 C-terminal ACT domain of biodegradative (catabolic) threonine dehydratase II (ThrD-II) and other related ACT domains; Region: ACT_ThrD-II-like; cd04886 441771010078 prolyl-tRNA synthetase; Provisional; Region: PRK09194 441771010079 Class II tRNA amino-acyl synthetase-like catalytic core domain. Class II amino acyl-tRNA synthetases (aaRS) share a common fold and generally attach an amino acid to the 3' OH of ribose of the appropriate tRNA. PheRS is an exception in that it...; Region: class_II_aaRS-like_core; cl00268 441771010080 motif 1; other site 441771010081 dimer interface [polypeptide binding]; other site 441771010082 active site 441771010083 motif 2; other site 441771010084 INS is an amino acid-editing domain inserted (INS) into the bacterial class II prolyl-tRNA synthetase (ProRS) however, this CD is not exclusively bacterial. It is also found at the N-terminus of the eukaryotic/archaea-like ProRS's of yeasts and...; Region: ProRS-INS; cd04334 441771010085 putative deacylase active site [active] 441771010086 ProRS Prolyl-anticodon binding domain, short version found predominantly in bacteria. ProRS belongs to class II aminoacyl-tRNA synthetases (aaRS). This alignment contains the anticodon binding domain, which is responsible for specificity in tRNA-binding; Region: ProRS_anticodon_short; cd00861 441771010087 anticodon binding site; other site 441771010088 CDP-ME synthetase is involved in mevalonate-independent isoprenoid production; Region: CDP-ME_synthetase; cd02516 441771010089 substrate binding site; other site 441771010090 dimer interface; other site 441771010091 Integral membrane protein (PIN domain superfamily) [General function prediction only]; Region: COG4956 441771010092 Tetrahydromethanopterin S-methyltransferase, subunit C; Region: MtrC; cl01677 441771010093 PIN domain of Thermus Thermophilus Hb8, uncharacterized Bacillus subtilis YacL, and other bacterial homologs; Region: PIN_YacL; cd09877 441771010094 putative active site [active] 441771010095 Nucleoside Triphosphate Pyrophosphohydrolase (EC 3.6.1.8) MazG-like domain superfamily; Region: NTP-PPase; cl16941 441771010096 DNA integrity scanning protein DisA; Provisional; Region: PRK13482 441771010097 DisA bacterial checkpoint controller nucleotide-binding; Region: DisA_N; pfam02457 441771010098 DisA bacterial checkpoint controller linker region; Region: DisA-linker; pfam10635 441771010099 DNA repair protein RadA; Provisional; Region: PRK11823 441771010100 Sms (bacterial radA) DNA repair protein. This protein is not related to archael radA any more than is to other RecA-like NTPases. Sms has a role in recombination and recombinational repair and is responsible for the stabilization or processing of...; Region: Sms; cd01121 441771010101 Walker A motif/ATP binding site; other site 441771010102 ATP binding site [chemical binding]; other site 441771010103 Walker B motif; other site 441771010104 Subunit ChlI of Mg-chelatase; Region: ChlI; pfam13541 441771010105 Clp protease ATP binding subunit; Region: clpC; CHL00095 441771010106 Clp amino terminal domain; Region: Clp_N; pfam02861 441771010107 Clp amino terminal domain; Region: Clp_N; pfam02861 441771010108 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 441771010109 Walker A motif; other site 441771010110 ATP binding site [chemical binding]; other site 441771010111 Walker B motif; other site 441771010112 arginine finger; other site 441771010113 UvrB/uvrC motif; Region: UVR; pfam02151 441771010114 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 441771010115 Walker A motif; other site 441771010116 ATP binding site [chemical binding]; other site 441771010117 Walker B motif; other site 441771010118 C-terminal, D2-small domain, of ClpB protein; Region: ClpB_D2-small; pfam10431 441771010119 ATP:guanido phosphotransferase; Provisional; Region: PRK01059 441771010120 Phosphagen (guanidino) kinases found in bacteria; Region: bacterial_phosphagen_kinase; cd07930 441771010121 ADP binding site [chemical binding]; other site 441771010122 phosphagen binding site; other site 441771010123 substrate specificity loop; other site 441771010124 Modulator of heat shock repressor CtsR, McsA [Signal transduction mechanisms]; Region: COG3880 441771010125 Firmicute transcriptional repressor of class III stress genes (CtsR); Region: CtsR; pfam05848 441771010126 Elongation factor G (EF-G) family; Region: EF-G_bact; cd04170 441771010127 elongation factor G; Reviewed; Region: PRK12740 441771010128 G1 box; other site 441771010129 putative GEF interaction site [polypeptide binding]; other site 441771010130 GTP/Mg2+ binding site [chemical binding]; other site 441771010131 Switch I region; other site 441771010132 G2 box; other site 441771010133 G3 box; other site 441771010134 Switch II region; other site 441771010135 G4 box; other site 441771010136 G5 box; other site 441771010137 EFG_mtEFG_II: this subfamily represents the domain II of elongation factor G (EF-G) in bacteria and, the C-terminus of mitochondrial Elongation factor G1 (mtEFG1) and G2 (mtEFG2)_like proteins found in eukaryotes. During the process of peptide synthesis...; Region: EFG_mtEFG_II; cd04088 441771010138 Elongation Factor G, domain II; Region: EFG_II; pfam14492 441771010139 EFG_mtEFG1_IV: domains similar to domain IV of the bacterial translational elongation factor (EF) EF-G. Included in this group is a domain of mitochondrial Elongation factor G1 (mtEFG1) proteins homologous to domain IV of EF-G. Eukaryotic cells harbor 2...; Region: EFG_mtEFG1_IV; cd01434 441771010140 EFG_mtEFG_C: domains similar to the C-terminal domain of the bacterial translational elongation factor (EF) EF-G. Included in this group is the C-terminus of mitochondrial Elongation factor G1 (mtEFG1) and G2 (mtEFG2) proteins. Eukaryotic cells harbor 2...; Region: EFG_mtEFG_C; cd03713 441771010141 UDP-N-acetylmuramoyl-L-alanyl-D-glutamate synthetase; Provisional; Region: murD; PRK01710 441771010142 Medium chain reductase/dehydrogenase (MDR)/zinc-dependent alcohol dehydrogenase-like family; Region: MDR; cl16912 441771010143 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl19134 441771010144 Mur ligase middle domain; Region: Mur_ligase_M; pfam08245 441771010145 Quinolinate phosphoribosyl transferase, C-terminal domain; Region: QRPTase_C; cl19145 441771010146 glycyl-tRNA synthetase; Provisional; Region: PRK04173 441771010147 Glycyl-tRNA synthetase (GlyRS)-like class II core catalytic domain. GlyRS functions as a homodimer in eukaryotes, archaea and some bacteria and as a heterotetramer in the remainder of prokaryotes. It is responsible for the attachment of glycine to the 3...; Region: GlyRS-like_core; cd00774 441771010148 dimer interface [polypeptide binding]; other site 441771010149 motif 1; other site 441771010150 active site 441771010151 motif 2; other site 441771010152 motif 3; other site 441771010153 GlyRS Glycyl-anticodon binding domain. GlyRS belongs to class II aminoacyl-tRNA synthetases (aaRS). This alignment contains the anticodon binding domain, which is responsible for specificity in tRNA-binding, so that the activated amino acid is...; Region: GlyRS_anticodon; cd00858 441771010154 anticodon binding site; other site 441771010155 lysyl-tRNA synthetase; Reviewed; Region: lysS; PRK00484 441771010156 LysRS_N: N-terminal, anticodon recognition domain of lysyl-tRNA synthetases (LysRS). These enzymes are homodimeric class 2b aminoacyl-tRNA synthetases (aaRSs). This domain is a beta-barrel domain (OB fold) involved in binding the tRNA anticodon stem-loop; Region: LysRS_N; cd04322 441771010157 dimer interface [polypeptide binding]; other site 441771010158 putative anticodon binding site; other site 441771010159 Lys_tRNA synthetase (LysRS) class II core domain. Class II LysRS is a dimer which attaches a lysine to the 3' OH group of ribose of the appropriate tRNA. Its assignment to class II aaRS is based upon its structure and the presence of three...; Region: LysRS_core; cd00775 441771010160 motif 1; other site 441771010161 active site 441771010162 motif 2; other site 441771010163 motif 3; other site 441771010164 transcription elongation factor GreA; Reviewed; Region: greA; PRK00226 441771010165 Transcription elongation factor, N-terminal; Region: GreA_GreB_N; pfam03449 441771010166 Transcription elongation factor, GreA/GreB, C-term; Region: GreA_GreB; pfam01272 441771010167 putative TIM-barrel protein, nifR3 family; Region: nifR3_yhdG; TIGR00737 441771010168 Dihydrouridine synthase-like (DUS-like) FMN-binding domain. Members of this family catalyze the reduction of the 5,6-double bond of a uridine residue on tRNA. Dihydrouridine modification of tRNA is widely observed in prokaryotes and eukaryotes, and also...; Region: DUS_like_FMN; cd02801 441771010169 FMN binding site [chemical binding]; other site 441771010170 active site 441771010171 catalytic residues [active] 441771010172 substrate binding site [chemical binding]; other site 441771010173 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cd00012 441771010174 nucleotide binding site [chemical binding]; other site 441771010175 Formyltetrahydrofolate synthetase (FTHFS) catalyzes the ATP-dependent activation of formate ion via its addition to the N10 position of tetrahydrofolate. FTHFS is a highly expressed key enzyme in both the Wood-Ljungdahl pathway of autotrophic CO2...; Region: FTHFS; cd00477 441771010176 Potassium binding sites [ion binding]; other site 441771010177 Cesium cation binding sites [ion binding]; other site 441771010178 FtsH Extracellular; Region: FtsH_ext; pfam06480 441771010179 ATP-dependent metalloprotease FtsH; Region: FtsH_fam; TIGR01241 441771010180 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 441771010181 Walker A motif; other site 441771010182 ATP binding site [chemical binding]; other site 441771010183 Walker B motif; other site 441771010184 arginine finger; other site 441771010185 Peptidase family M41; Region: Peptidase_M41; pfam01434 441771010186 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 441771010187 active site 441771010188 tRNA(Ile)-lysidine synthase MesJ [Cell cycle control, cell division, chromosome partitioning]; Region: MesJ; COG0037 441771010189 N-terminal domain of predicted ATPase of the PP-loop faimly implicated in cell cycle control [Cell division and chromosome partitioning]. This is a subfamily of Adenine nucleotide alpha hydrolases superfamily.Adeninosine nucleotide alpha hydrolases...; Region: PP-ATPase; cd01992 441771010190 Ligand Binding Site [chemical binding]; other site 441771010191 TilS substrate C-terminal domain; Region: TilS_C; smart00977 441771010192 stage II sporulation protein E; Region: spore_II_E; TIGR02865 441771010193 Stage II sporulation protein E (SpoIIE); Region: SpoIIE; pfam07228 441771010194 hypothetical protein; Provisional; Region: PRK05807 441771010195 S1_RPS1_repeat_hs4: Ribosomal protein S1 (RPS1) domain. RPS1 is a component of the small ribosomal subunit thought to be involved in the recognition and binding of mRNA's during translation initiation. The bacterial RPS1 domain architecture consists...; Region: S1_RPS1_repeat_hs4; cd05692 441771010196 RNA binding site [nucleotide binding]; other site 441771010197 Septum formation initiator; Region: DivIC; pfam04977 441771010198 spore cortex biosynthesis protein YabQ; Region: spore_yabQ; TIGR02893 441771010199 sporulation protein YabP; Region: spore_yabP; TIGR02892 441771010200 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 441771010201 RNA binding surface [nucleotide binding]; other site 441771010202 histone-like DNA-binding protein HU; Region: HU; cd13831 441771010203 dimer interface [polypeptide binding]; other site 441771010204 DNA binding site [nucleotide binding] 441771010205 Protein containing tetrapyrrole methyltransferase domain and MazG-like (predicted pyrophosphatase) domain [General function prediction only]; Region: COG3956 441771010206 N-terminal S-AdoMet dependent methylase domain of Bacillus subtilis YabN and related proteins; Region: YabN_N; cd11723 441771010207 putative SAM binding site [chemical binding]; other site 441771010208 putative homodimer interface [polypeptide binding]; other site 441771010209 Nucleoside Triphosphate Pyrophosphohydrolase (EC 3.6.1.8) N-terminal tandem-domain of MazG proteins from Escherichia coli and bacterial homologs; Region: NTP-PPase_MazG_Nterm; cd11528 441771010210 homodimer interface [polypeptide binding]; other site 441771010211 metal binding site [ion binding]; metal-binding site 441771010212 Nucleoside Triphosphate Pyrophosphohydrolase (EC 3.6.1.8) C-terminal tandem-domain of MazG proteins from Escherichia coli and bacterial homologs' Region: NTP-PPase_MazG_Cterm; cd11529 441771010213 homodimer interface [polypeptide binding]; other site 441771010214 active site 441771010215 putative chemical substrate binding site [chemical binding]; other site 441771010216 metal binding site [ion binding]; metal-binding site 441771010217 stage V sporulation protein B; Region: spore_V_B; TIGR02900 441771010218 Stage V sporulation protein B, also known as Stage III sporulation protein F, and related proteins; Region: MATE_SpoVB_like; cd13124 441771010219 Regulators of stationary/sporulation gene expression [Transcription]; Region: AbrB; COG2002 441771010220 stage V sporulation protein T; Region: spore_V_T; TIGR02851 441771010221 GAF domain; Region: GAF_2; pfam13185 441771010222 peptidylprolyl isomerase; Provisional; Region: prsA; PRK00059 441771010223 SurA N-terminal domain; Region: SurA_N_3; cl07813 441771010224 PPIC-type PPIASE domain; Region: Rotamase; pfam00639 441771010225 Transcription-repair coupling factor (superfamily II helicase) [DNA replication, recombination, and repair / Transcription]; Region: Mfd; COG1197 441771010226 CarD-like/TRCF domain; Region: CarD_TRCF; smart01058 441771010227 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 441771010228 ATP binding site [chemical binding]; other site 441771010229 putative Mg++ binding site [ion binding]; other site 441771010230 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 441771010231 nucleotide binding region [chemical binding]; other site 441771010232 ATP-binding site [chemical binding]; other site 441771010233 TRCF domain; Region: TRCF; pfam03461 441771010234 Peptidyl-tRNA hydrolase (PTH) is a monomeric protein that cleaves the ester bond linking the nascent peptide and tRNA when peptidyl-tRNA is released prematurely from the ribosome. This ensures the recycling of peptidyl-tRNAs into tRNAs produced through...; Region: PTH; cd00462 441771010235 putative active site [active] 441771010236 catalytic residue [active] 441771010237 Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain [Posttranslational modification, protein turnover, chaperones]; Region: DegQ; COG0265 441771010238 Trypsin-like peptidase domain; Region: Trypsin_2; pfam13365 441771010239 PDZ domain of trypsin-like serine proteases, such as DegP/HtrA, which are oligomeric proteins involved in heat-shock response, chaperone function, and apoptosis. May be responsible for substrate recognition and/or binding, as most PDZ domains bind...; Region: PDZ_serine_protease; cd00987 441771010240 protein binding site [polypeptide binding]; other site 441771010241 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 441771010242 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 441771010243 dimerization interface [polypeptide binding]; other site 441771010244 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 441771010245 dimer interface [polypeptide binding]; other site 441771010246 phosphorylation site [posttranslational modification] 441771010247 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 441771010248 ATP binding site [chemical binding]; other site 441771010249 Mg2+ binding site [ion binding]; other site 441771010250 G-X-G motif; other site 441771010251 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 441771010252 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 441771010253 active site 441771010254 phosphorylation site [posttranslational modification] 441771010255 intermolecular recognition site; other site 441771010256 dimerization interface [polypeptide binding]; other site 441771010257 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 441771010258 DNA binding site [nucleotide binding] 441771010259 ribose-phosphate pyrophosphokinase; Provisional; Region: PRK01259 441771010260 N-terminal domain of ribose phosphate pyrophosphokinase; Region: Pribosyltran_N; pfam13793 441771010261 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 441771010262 active site 441771010263 bifunctional N-acetylglucosamine-1-phosphate uridyltransferase/glucosamine-1-phosphate acetyltransferase; Provisional; Region: glmU; PRK14354 441771010264 N-terminal domain of bacterial GlmU; Region: GT2_GlmU_N_bac; cd02540 441771010265 Substrate binding site; other site 441771010266 Mg++ binding site; other site 441771010267 N-acetyl-glucosamine-1-phosphate uridyltransferase (GlmU), C-terminal left-handed beta-helix (LbH) acetyltransferase domain: GlmU is also known as UDP-N-acetylglucosamine pyrophosphorylase. It is a bifunctional bacterial enzyme that catalyzes two...; Region: LbH_GlmU_C; cd03353 441771010268 active site 441771010269 substrate binding site [chemical binding]; other site 441771010270 CoA binding site [chemical binding]; other site 441771010271 regulatory protein SpoVG; Reviewed; Region: PRK13259 441771010272 pur operon repressor; Provisional; Region: PRK09213 441771010273 Bacterial purine repressor, N-terminal; Region: PuR_N; pfam09182 441771010274 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 441771010275 active site 441771010276 UDP-N-acetylmuramate--L-alanine ligase; Provisional; Region: murC; PRK00421 441771010277 Mur ligase family, catalytic domain; Region: Mur_ligase; pfam01225 441771010278 Mur ligase middle domain; Region: Mur_ligase_M; pfam08245 441771010279 Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875 441771010280 Iron only hydrogenase large subunit, C-terminal domain [General function prediction only]; Region: COG4624 441771010281 The HCP family of iron-sulfur proteins includes hybrid cluster protein (HCP), acetyl-CoA synthase (ACS), and carbon monoxide dehydrogenase (CODH), all of which contain [Fe4-S4] metal clusters at their active sites. These proteins have a conserved...; Region: HCP_like; cl19102 441771010282 4Fe-4S binding domain; Region: Fer4; pfam00037 441771010283 Iron only hydrogenase large subunit, C-terminal domain; Region: Fe_hyd_lg_C; pfam02906 441771010284 Predicted phosphatase/phosphohexomutase [General function prediction only]; Region: COG0637 441771010285 haloacid dehalogenase-like hydrolase; Region: HAD; pfam12710 441771010286 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 441771010287 motif II; other site 441771010288 2-phosphosulfolactate phosphatase; Provisional; Region: PRK00886 441771010289 Predicted Fe-S oxidoreductase [General function prediction only]; Region: COG1242 441771010290 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 441771010291 FeS/SAM binding site; other site 441771010292 Solute carrier families 5 and 6-like; solute binding domain; Region: SLC5-6-like_sbd; cl00456 441771010293 DRE-TIM metallolyase superfamily; Region: DRE_TIM_metallolyase; cl18962 441771010294 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 441771010295 FeS/SAM binding site; other site 441771010296 Heme NO binding; Region: HNOB; pfam07700 441771010297 Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer); Region: MA; smart00283 441771010298 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cl19050 441771010299 dimer interface [polypeptide binding]; other site 441771010300 putative CheW interface [polypeptide binding]; other site 441771010301 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 441771010302 non-specific DNA binding site [nucleotide binding]; other site 441771010303 salt bridge; other site 441771010304 sequence-specific DNA binding site [nucleotide binding]; other site 441771010305 Domain of unknown function (DUF3783); Region: DUF3783; pfam12646 441771010306 cyclophilin: cyclophilin-type peptidylprolyl cis- trans isomerases. This family contains eukaryotic, bacterial and archeal proteins which exhibit a peptidylprolyl cis- trans isomerases activity (PPIase, Rotamase) and in addition bind the...; Region: cyclophilin; cd00317 441771010307 active site 441771010308 glutamate racemase; Provisional; Region: PRK00865 441771010309 Glutamine synthetase [Amino acid transport and metabolism]; Region: GlnA; COG0174 441771010310 Glutamine synthetase, catalytic domain; Region: Gln-synt_C; pfam00120 441771010311 2'-5' RNA ligase [Translation, ribosomal structure and biogenesis]; Region: LigT; COG1514 441771010312 EPSP synthase (3-phosphoshikimate 1-carboxyvinyltransferase); Region: EPSP_synthase; pfam00275 441771010313 UDP-N-acetylglucosamine enolpyruvyl transferase catalyzes enolpyruvyl transfer as part of the first step in the biosynthesis of peptidoglycan, a component of the bacterial cell wall. The reaction is phosphoenolpyruvate + UDP-N-acetyl-D-glucosamine =...; Region: UdpNAET; cd01555 441771010314 hinge; other site 441771010315 active site 441771010316 Metal-dependent hydrolases of the beta-lactamase superfamily I [General function prediction only]; Region: PhnP; COG1235 441771010317 Sporulation and spore germination; Region: Germane; pfam10646 441771010318 hypothetical protein; Provisional; Region: PRK05590 441771010319 SEC-C motif; Region: SEC-C; pfam02810 441771010320 rRNA large subunit methyltransferase; Provisional; Region: PRK00103 441771010321 Arabinose efflux permease [Carbohydrate transport and metabolism]; Region: AraJ; COG2814 441771010322 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 441771010323 putative substrate translocation pore; other site 441771010324 Multimeric flavodoxin WrbA [General function prediction only]; Region: WrbA; COG0655 441771010325 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 441771010326 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 441771010327 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 441771010328 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 441771010329 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 441771010330 methionine aminopeptidase; Provisional; Region: PRK12318 441771010331 SEC-C motif; Region: SEC-C; pfam02810 441771010332 Methionine Aminopeptidase 1. E.C. 3.4.11.18. Also known as methionyl aminopeptidase and Peptidase M. Catalyzes release of N-terminal amino acids, preferentially methionine, from peptides and arylamides; Region: MetAP1; cd01086 441771010333 active site 441771010334 Nitroreductase-like family 3. A subfamily of the nitroreductase family containing uncharacterized proteins that are similar to nitroreductase. Nitroreductase catalyzes the reduction of nitroaromatic compounds such as nitrotoluenes, nitrofurans and...; Region: Nitroreductase_3; cd02139 441771010335 putative FMN binding site [chemical binding]; other site 441771010336 glycine radical enzyme, YjjI family; Region: glycyl_YjjI; TIGR04040 441771010337 Pyruvate formate lyase; Region: PFL; pfam02901 441771010338 glycine radical enzyme activase, YjjW family; Region: activase_YjjW; TIGR04041 441771010339 DRE-TIM metallolyase superfamily; Region: DRE_TIM_metallolyase; cl18962 441771010340 DRE-TIM metallolyase superfamily; Region: DRE_TIM_metallolyase; cl18962 441771010341 putative iron-only hydrogenase system regulator; Region: hyd_TM1266; TIGR03959 441771010342 [FeFe] hydrogenase H-cluster radical SAM maturase HydE; Region: rSAM_HydE; TIGR03956 441771010343 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 441771010344 FeS/SAM binding site; other site 441771010345 thiamine biosynthesis protein ThiH; Reviewed; Region: thiH; PRK09613 441771010346 VHS, ENTH and ANTH domain superfamily; composed of proteins containing a VHS, ENTH or ANTH domain. The VHS domain is present in Vps27 (Vacuolar Protein Sorting), Hrs (Hepatocyte growth factor-regulated tyrosine kinase substrate) and STAM (Signal...; Region: VHS_ENTH_ANTH; cl02544 441771010347 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 441771010348 FeS/SAM binding site; other site 441771010349 Biotin and Thiamin Synthesis associated domain; Region: BATS; smart00876 441771010350 [FeFe] hydrogenase H-cluster maturation GTPase HydF; Region: GTP_HydF; TIGR03918 441771010351 E. coli Ras-like protein (Era)-like GTPase; Region: Era_like; cd00880 441771010352 G1 box; other site 441771010353 GTP/Mg2+ binding site [chemical binding]; other site 441771010354 Switch I region; other site 441771010355 G2 box; other site 441771010356 Switch II region; other site 441771010357 G3 box; other site 441771010358 G4 box; other site 441771010359 G5 box; other site 441771010360 Solute carrier 5 family, sodium/glucose transporters and related proteins; solute-binding domain; Region: SLC5sbd; cd10322 441771010361 Na binding site [ion binding]; other site 441771010362 Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013 441771010363 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 441771010364 Predicted metal-dependent phosphoesterases (PHP family) [General function prediction only]; Region: COG0613 441771010365 Polymerase and Histidinol Phosphatase domain of Histidinol phosphate phosphatase; Region: PHP_HisPPase; cd07432 441771010366 active site 441771010367 PHP-associated; Region: PHP_C; pfam13263 441771010368 dUTPase; Region: dUTPase_2; pfam08761 441771010369 Nucleoside Triphosphate Pyrophosphohydrolase (EC 3.6.1.8) MazG-like domain found in dimeric 2-Deoxyuridine 5'-triphosphate nucleotidohydrolase and similar proteins; Region: NTP-PPase_dUTPase; cd11527 441771010370 active site 441771010371 homodimer interface [polypeptide binding]; other site 441771010372 metal binding site [ion binding]; metal-binding site 441771010373 Protein of unknown function, DUF606; Region: DUF606; pfam04657 441771010374 Transcriptional regulator [Transcription]; Region: LysR; COG0583 441771010375 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 441771010376 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 441771010377 dimerization interface [polypeptide binding]; other site 441771010378 Peptidase domain in the S8 and S53 families; Region: Peptidases_S8_S53; cl10459 441771010379 Subtilase family; Region: Peptidase_S8; pfam00082 441771010380 active site 441771010381 catalytic residues [active] 441771010382 putative DNA-binding transcriptional regulator; Provisional; Region: PRK10837 441771010383 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 441771010384 C-terminal substrate binding domain of LysR-type transcriptional regulator CysL, which activates the transcription of the cysJI operon encoding sulfite reductase, contains the type 2 periplasmic binding fold; Region: PBP2_CysL_like; cd08420 441771010385 putative dimerization interface [polypeptide binding]; other site 441771010386 Phosphoglycerate dehydrogenase and related dehydrogenases [Amino acid transport and metabolism]; Region: SerA; COG0111 441771010387 Phosphoglycerate Dehydrogenase, 2-hydroxyacid dehydrogenase family; Region: PGDH_1; cd12155 441771010388 putative ligand binding site [chemical binding]; other site 441771010389 NAD binding site [chemical binding]; other site 441771010390 catalytic site [active] 441771010391 Acetyl co-enzyme A carboxylase carboxyltransferase alpha subunit; Region: ACCA; cl19172 441771010392 acetyl-CoA carboxylase subunit beta; Validated; Region: PRK05654 441771010393 biotin carboxylase; Validated; Region: PRK05586 441771010394 Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289 441771010395 Carbamoyl-phosphate synthase L chain, ATP binding domain; Region: CPSase_L_D2; pfam02786 441771010396 Biotin carboxylase C-terminal domain; Region: Biotin_carb_C; smart00878 441771010397 FabZ is a 17kD beta-hydroxyacyl-acyl carrier protein (ACP) dehydratase that primarily catalyzes the dehydration of beta-hydroxyacyl-ACP to trans-2-acyl-ACP, the third step in the elongation phase of the bacterial/ plastid, type II, fatty-acid...; Region: FabZ; cd01288 441771010398 acetyl-CoA carboxylase biotin carboxyl carrier protein subunit; Validated; Region: PRK06302 441771010399 The biotinyl-domain or biotin carboxyl carrier protein (BCCP) domain is present in all biotin-dependent enzymes, such as acetyl-CoA carboxylase, pyruvate carboxylase, propionyl-CoA carboxylase, methylcrotonyl-CoA carboxylase, geranyl-CoA carboxylase; Region: biotinyl_domain; cd06850 441771010400 carboxyltransferase (CT) interaction site; other site 441771010401 biotinylation site [posttranslational modification]; other site 441771010402 beta-ketoacyl-acyl-carrier-protein synthase II; Region: fabF; TIGR03150 441771010403 Beta-ketoacyl-acyl carrier protein (ACP) synthase (KAS), type I and II. KASs are responsible for the elongation steps in fatty acid biosynthesis. KASIII catalyses the initial condensation and KAS I and II catalyze further elongation steps by Claisen...; Region: KAS_I_II; cd00834 441771010404 dimer interface [polypeptide binding]; other site 441771010405 active site 441771010406 3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05557 441771010407 beta-Keto acyl carrier protein reductase (BKR), involved in Type II FAS, classical (c) SDRs; Region: BKR_SDR_c; cd05333 441771010408 NAD(P) binding site [chemical binding]; other site 441771010409 homotetramer interface [polypeptide binding]; other site 441771010410 homodimer interface [polypeptide binding]; other site 441771010411 active site 441771010412 (acyl-carrier-protein) S-malonyltransferase [Lipid metabolism]; Region: FabD; COG0331 441771010413 putative enoyl-[acyl-carrier-protein] reductase II; Region: enACPred_II; TIGR03151 441771010414 2-Nitropropane dioxygenase (NPD), one of the nitroalkane oxidizing enzyme families, catalyzes oxidative denitrification of nitroalkanes to their corresponding carbonyl compounds and nitrites. NDP is a member of the NAD(P)H-dependent flavin oxidoreductase...; Region: NPD_like; cd04730 441771010415 FMN binding site [chemical binding]; other site 441771010416 substrate binding site [chemical binding]; other site 441771010417 putative catalytic residue [active] 441771010418 acyl carrier protein; Provisional; Region: acpP; PRK00982 441771010419 3-oxoacyl-(acyl carrier protein) synthase III; Reviewed; Region: PRK09352 441771010420 Ketoacyl-acyl carrier protein synthase III (KASIII) initiates the elongation in type II fatty acid synthase systems. It is found in bacteria and plants. Elongation of fatty acids in the type II systems occurs by Claisen condensation of malonyl-acyl...; Region: KAS_III; cd00830 441771010421 dimer interface [polypeptide binding]; other site 441771010422 active site 441771010423 CoA binding pocket [chemical binding]; other site 441771010424 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cl17220 441771010425 Transcriptional regulators [Transcription]; Region: MarR; COG1846 441771010426 Dioxygenases related to 2-nitropropane dioxygenase [General function prediction only]; Region: COG2070 441771010427 2-Nitropropane dioxygenase (NPD), one of the nitroalkane oxidizing enzyme families, catalyzes oxidative denitrification of nitroalkanes to their corresponding carbonyl compounds and nitrites. NDP is a member of the NAD(P)H-dependent flavin oxidoreductase...; Region: NPD_like; cd04730 441771010428 FMN binding site [chemical binding]; other site 441771010429 substrate binding site [chemical binding]; other site 441771010430 putative catalytic residue [active] 441771010431 Membrane proteins related to metalloendopeptidases [Cell envelope biogenesis, outer membrane]; Region: NlpD; COG0739 441771010432 Peptidase family M23; Region: Peptidase_M23; pfam01551 441771010433 Putative primosome component and related proteins [DNA replication, recombination, and repair]; Region: DnaD; COG3935 441771010434 Replication initiation and membrane attachment; Region: DnaB_2; pfam07261 441771010435 Replication initiation and membrane attachment; Region: DnaB_2; cl12121 441771010436 DNA replication protein DnaC; Validated; Region: PRK06835 441771010437 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 441771010438 Walker A motif; other site 441771010439 ATP binding site [chemical binding]; other site 441771010440 Walker B motif; other site 441771010441 arginine finger; other site 441771010442 PEP synthetase regulatory protein; Provisional; Region: PRK05339 441771010443 CoA binding domain; Region: CoA_binding_2; pfam13380 441771010444 flavoprotein, HI0933 family; Region: TIGR00275 441771010445 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl19134 441771010446 Acyl-ACP thioesterase; Region: Acyl-ACP_TE; pfam01643 441771010447 4-hydroxybenzoyl-CoA thioesterase (4HBT). Catalyzes the final step in the 4-chlorobenzoate degradation pathway in which 4-chlorobenzoate is converted to 4-hydroxybenzoate in certain soil-dwelling bacteria. 4HBT forms a homotetramer with four active sites; Region: 4HBT; cd00586 441771010448 active site 441771010449 4-hydroxybenzoyl-CoA thioesterase (4HBT). Catalyzes the final step in the 4-chlorobenzoate degradation pathway in which 4-chlorobenzoate is converted to 4-hydroxybenzoate in certain soil-dwelling bacteria. 4HBT forms a homotetramer with four active sites; Region: 4HBT; cd00586 441771010450 active site 441771010451 hybrid cluster protein-associated redox disulfide domain; Region: prismane_assoc; TIGR03980 441771010452 Adenylosuccinate synthetase (AdSS) catalyzes the first step in the de novo biosynthesis of AMP. IMP and L-aspartate are conjugated in a two-step reaction accompanied by the hydrolysis of GTP to GDP in the presence of Mg2+. In the first step, the...; Region: AdSS; cd03108 441771010453 GDP-binding site [chemical binding]; other site 441771010454 ACT binding site; other site 441771010455 IMP binding site; other site 441771010456 Uncharacterized FAD-dependent dehydrogenases [General function prediction only]; Region: COG2509 441771010457 Protein of unknown function (DUF3006); Region: DUF3006; pfam11213 441771010458 phosphoglucomutase-2-like protein; Provisional; Region: PTZ00150 441771010459 This CD includes PGM2 (phosphoglucomutase 2) and PGM2L1 (phosphoglucomutase 2-like 1). The mammalian PGM2 is thought to be a phosphopentomutase that catalyzes the conversion of the nucleoside breakdown products, ribose-1-phosphate and...; Region: PGM2; cd05799 441771010460 active site 441771010461 substrate binding site [chemical binding]; other site 441771010462 metal binding site [ion binding]; metal-binding site 441771010463 replicative DNA helicase; Provisional; Region: PRK05595 441771010464 DnaB-like helicase N terminal domain; Region: DnaB; pfam00772 441771010465 DnaB helicase C terminal domain. The hexameric helicase DnaB unwinds the DNA duplex at the chromosome replication fork. Although the mechanism by which DnaB both couples ATP hydrolysis to translocation along DNA and denatures the duplex is unknown, a...; Region: DnaB_C; cd00984 441771010466 Walker A motif; other site 441771010467 ATP binding site [chemical binding]; other site 441771010468 Walker B motif; other site 441771010469 DNA binding loops [nucleotide binding] 441771010470 ATP-dependent protease, Lon family; Region: spore_lon_C; TIGR02903 441771010471 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 441771010472 Walker A motif; other site 441771010473 ATP binding site [chemical binding]; other site 441771010474 Walker B motif; other site 441771010475 arginine finger; other site 441771010476 Lon protease (S16) C-terminal proteolytic domain; Region: Lon_C; pfam05362 441771010477 50S ribosomal protein L9; Reviewed; Region: rplI; PRK00137 441771010478 Ribosomal protein L9, N-terminal domain; Region: Ribosomal_L9_N; pfam01281 441771010479 Ribosomal protein L9, C-terminal domain; Region: Ribosomal_L9_C; pfam03948 441771010480 Predicted signaling protein consisting of a modified GGDEF domain and a DHH domain [Signal transduction mechanisms]; Region: COG3887 441771010481 DHH family; Region: DHH; pfam01368 441771010482 DHHA1 domain; Region: DHHA1; pfam02272 441771010483 Predicted membrane protein (DUF2232); Region: DUF2232; pfam09991 441771010484 MazG-like family; Region: MazG-like; pfam12643 441771010485 30S ribosomal protein S18; Reviewed; Region: rpsR; PRK00391 441771010486 Single-stranded DNA-binding protein [DNA replication, recombination, and repair]; Region: Ssb; COG0629 441771010487 SSB_OBF: A subfamily of OB folds similar to the OB fold of ssDNA-binding protein (SSB). SSBs bind with high affinity to ssDNA. They bind to and protect ssDNA intermediates during DNA metabolic pathways. All bacterial and eukaryotic SSBs studied to date...; Region: SSB_OBF; cd04496 441771010488 dimer interface [polypeptide binding]; other site 441771010489 ssDNA binding site [nucleotide binding]; other site 441771010490 tetramer (dimer of dimers) interface [polypeptide binding]; other site 441771010491 30S ribosomal protein S6; Reviewed; Region: rpsF; PRK00453 441771010492 Benzoyl-CoA reductase/2-hydroxyglutaryl-CoA dehydratase subunit, BcrC/BadD/HgdB [Amino acid transport and metabolism]; Region: HgdB; COG1775 441771010493 2-hydroxyglutaryl-CoA dehydratase, D-component; Region: HGD-D; pfam06050 441771010494 Bacterial protein of unknown function (DUF951); Region: DUF951; pfam06107 441771010495 Small-conductance mechanosensitive channel [Cell envelope biogenesis, outer membrane]; Region: MscS; COG0668 441771010496 Mechanosensitive ion channel; Region: MS_channel; pfam00924 441771010497 Protein of unknown function (DUF3343); Region: DUF3343; pfam11823 441771010498 Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl18945 441771010499 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 441771010500 catalytic residue [active] 441771010501 Domain of unknown function DUF20; Region: UPF0118; cl00465 441771010502 Protein of unknown function (DUF1256); Region: DUF1256; cl06087 441771010503 Protein of unknown function (DUF4446); Region: DUF4446; pfam14584 441771010504 ParB/RepB/Spo0J family partition protein; Region: parB_part; TIGR00180 441771010505 ParB-like nuclease domain; Region: ParB; smart00470 441771010506 ATPases involved in chromosome partitioning [Cell division and chromosome partitioning]; Region: Soj; COG1192 441771010507 ParA and ParB of Caulobacter crescentus belong to a conserved family of bacterial proteins implicated in chromosome segregation. ParB binds to DNA sequences adjacent to the origin of replication and localizes to opposite cell poles shortly following the...; Region: ParA; cd02042 441771010508 P-loop; other site 441771010509 Magnesium ion binding site [ion binding]; other site 441771010510 nucleoid occlusion protein; Region: nucleoid_noc; TIGR04285 441771010511 ParB-like nuclease domain; Region: ParBc; pfam02195 441771010512 16S rRNA methyltransferase GidB; Reviewed; Region: gidB; PRK00107 441771010513 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 441771010514 S-adenosylmethionine binding site [chemical binding]; other site 441771010515 tRNA uridine 5-carboxymethylaminomethyl modification enzyme GidA; Validated; Region: PRK05192 441771010516 NAD(FAD)-utilizing enzyme possibly involved in translation [Translation, ribosomal structure and biogenesis]; Region: Gid; COG1206 441771010517 GidA associated domain 3; Region: GIDA_assoc_3; pfam13932 441771010518 tRNA modification GTPase TrmE; Reviewed; Region: trmE; PRK05291 441771010519 GTP-binding protein TrmE N-terminus; Region: TrmE_N; pfam10396 441771010520 trmE is a tRNA modification GTPase; Region: trmE; cd04164 441771010521 G1 box; other site 441771010522 GTP/Mg2+ binding site [chemical binding]; other site 441771010523 Switch I region; other site 441771010524 G2 box; other site 441771010525 Switch II region; other site 441771010526 G3 box; other site 441771010527 G4 box; other site 441771010528 G5 box; other site 441771010529 Catalytic cysteine-containing C-terminus of GTPase, MnmE; Region: GTPase_Cys_C; pfam12631 441771010530 Predicted RNA-binding protein [General function prediction only]; Region: Jag; COG1847 441771010531 Jag N-terminus; Region: Jag_N; pfam14804 441771010532 jag_K homology RNA-binding domain. The KH domain is found in proteins homologous to the Bacillus subtilis protein Jag, which is associated with SpoIIIJ and is necessary for the third stage of sporulation. The KH motif is a beta-alpha-alpha-beta-beta...; Region: jag_KH; cd02414 441771010533 G-X-X-G motif; other site 441771010534 R3H domain found in proteins homologous to Bacillus subtilus Jag, which is associated with SpoIIIJ. SpoIIIJ is necessary for the third stage of sporulation. The name of the R3H domain comes from the characteristic spacing of the most conserved arginine...; Region: R3H_jag; cd02644 441771010535 RxxxH motif; other site 441771010536 putative inner membrane protein translocase component YidC; Provisional; Region: PRK00145 441771010537 Haemolytic domain; Region: Haemolytic; pfam01809 441771010538 ribonuclease P; Reviewed; Region: rnpA; PRK00499 441771010539 50S ribosomal protein L34; Reviewed; Region: rpmH; PRK00399