-- dump date 20140619_042427 -- class Genbank::misc_feature -- table misc_feature_note -- id note 991791000001 Short-chain dehydrogenases of various substrate specificities [General function prediction only]; Region: DltE; COG0300 991791000002 classical (c) SDRs; Region: SDR_c; cd05233 991791000003 NAD(P) binding site [chemical binding]; other site 991791000004 active site 991791000005 Bacterial surface proteins containing Ig-like domains [Cell motility and secretion]; Region: COG5492 991791000006 Clostridial hydrophobic, with a conserved W residue, domain; Region: ChW; smart00728 991791000007 Clostridial hydrophobic, with a conserved W residue, domain; Region: ChW; smart00728 991791000008 Clostridial hydrophobic, with a conserved W residue, domain; Region: ChW; smart00728 991791000009 Bacterial Ig-like domain (group 2); Region: Big_2; cl02708 991791000010 Bacterial surface proteins containing Ig-like domains [Cell motility and secretion]; Region: COG5492 991791000011 Clostridial hydrophobic, with a conserved W residue, domain; Region: ChW; smart00728 991791000012 Clostridial hydrophobic, with a conserved W residue, domain; Region: ChW; smart00728 991791000013 Clostridial hydrophobic, with a conserved W residue, domain; Region: ChW; smart00728 991791000014 Bacterial Ig-like domain (group 2); Region: Big_2; pfam02368 991791000015 Uncharacterized protein involved in cytokinesis, contains TGc (transglutaminase/protease-like) domain [Cell division and chromosome partitioning]; Region: CYK3; COG5279 991791000016 Transglutaminase-like superfamily; Region: Transglut_core; pfam01841 991791000017 Bacterial surface proteins containing Ig-like domains [Cell motility and secretion]; Region: COG5492 991791000018 Clostridial hydrophobic, with a conserved W residue, domain; Region: ChW; smart00728 991791000019 Clostridial hydrophobic, with a conserved W residue, domain; Region: ChW; smart00728 991791000020 Clostridial hydrophobic, with a conserved W residue, domain; Region: ChW; smart00728 991791000021 Bacterial Ig-like domain (group 2); Region: Big_2; pfam02368 991791000022 Bacterial surface proteins containing Ig-like domains [Cell motility and secretion]; Region: COG5492 991791000023 Clostridial hydrophobic, with a conserved W residue, domain; Region: ChW; smart00728 991791000024 Clostridial hydrophobic, with a conserved W residue, domain; Region: ChW; smart00728 991791000025 Clostridial hydrophobic, with a conserved W residue, domain; Region: ChW; smart00728 991791000026 Bacterial Ig-like domain (group 2); Region: Big_2; pfam02368 991791000027 Uncharacterized protein involved in cytokinesis, contains TGc (transglutaminase/protease-like) domain [Cell division and chromosome partitioning]; Region: CYK3; COG5279 991791000028 Transglutaminase-like superfamily; Region: Transglut_core; pfam01841 991791000029 Cysteine protease [Posttranslational modification, protein turnover, chaperones]; Region: COG4870 991791000030 C1 Peptidase family (MEROPS database nomenclature), also referred to as the papain family; composed of two subfamilies of cysteine peptidases (CPs), C1A (papain) and C1B (bleomycin hydrolase). Papain-like enzymes are mostly endopeptidases with some...; Region: Peptidase_C1; cd02619 991791000031 active site 991791000032 Enterocin A Immunity; Region: EntA_Immun; pfam08951 991791000033 Transcriptional regulators [Transcription]; Region: PhnF; COG2188 991791000034 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 991791000035 DNA-binding site [nucleotide binding]; DNA binding site 991791000036 UTRA domain; Region: UTRA; pfam07702 991791000037 Response regulator containing CheY-like receiver and SARP domains [Signal transduction mechanisms]; Region: COG3947 991791000038 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cl17736 991791000039 active site 991791000040 phosphorylation site [posttranslational modification] 991791000041 dimerization interface [polypeptide binding]; other site 991791000042 Beta-glucosidase/6-phospho-beta-glucosidase/beta- galactosidase [Carbohydrate transport and metabolism]; Region: BglB; COG2723 991791000043 beta-galactosidase; Region: BGL; TIGR03356 991791000044 Dehydrogenases (flavoproteins) [Energy production and conversion]; Region: FixC; COG0644 991791000045 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450 991791000046 Protein tyrosine phosphatase, catalytic domain motif; Region: PTPc_motif; smart00404 991791000047 active site 991791000048 Glycerophosphoryl diester phosphodiesterase [Energy production and conversion]; Region: UgpQ; COG0584 991791000049 Glycerophosphodiester phosphodiesterase domain of uncharacterized bacterial glycerophosphodiester phosphodiesterases; Region: GDPD_memb_like; cd08579 991791000050 putative active site [active] 991791000051 catalytic site [active] 991791000052 putative metal binding site [ion binding]; other site 991791000053 Predicted membrane protein [Function unknown]; Region: COG4331 991791000054 spore germination protein (amino acid permease); Region: 2A0309; TIGR00912 991791000055 germination protein, Ger(x)C family; Region: spore_ger_x_C; TIGR02887 991791000056 Spore germination B3/ GerAC like, C-terminal; Region: Spore_GerAC; pfam05504 991791000057 Bacillus/Clostridium GerA spore germination protein; Region: GerA; pfam03323 991791000058 Spore germination protein; Region: Spore_permease; pfam03845 991791000059 helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347 991791000060 MarR family; Region: MarR_2; pfam12802 991791000061 MarR family; Region: MarR_2; cl17246 991791000062 Pyruvate decarboxylase and related thiamine pyrophosphate-requiring enzymes [Carbohydrate transport and metabolism / Coenzyme metabolism / General function prediction only]; Region: COG3961 991791000063 Pyrimidine (PYR) binding domain of pyruvate decarboxylase (PDC), indolepyruvate decarboxylase (IPDC) and related proteins; Region: TPP_PYR_PDC_IPDC_like; cd07038 991791000064 dimer interface [polypeptide binding]; other site 991791000065 PYR/PP interface [polypeptide binding]; other site 991791000066 TPP binding site [chemical binding]; other site 991791000067 Thiamine pyrophosphate enzyme, central domain; Region: TPP_enzyme_M; pfam00205 991791000068 Thiamine pyrophosphate (TPP) family, PDC_IPDC subfamily, TPP-binding module; composed of proteins similar to pyruvate decarboxylase (PDC) and indolepyruvate decarboxylase (IPDC). PDC, a key enzyme in alcoholic fermentation, catalyzes the conversion of...; Region: TPP_PDC_IPDC; cd02005 991791000069 TPP-binding site [chemical binding]; other site 991791000070 dimer interface [polypeptide binding]; other site 991791000071 Amino acid permease; Region: AA_permease_2; pfam13520 991791000072 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 991791000073 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 991791000074 WHG domain; Region: WHG; pfam13305 991791000075 drug efflux system protein MdtG; Provisional; Region: PRK09874 991791000076 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 991791000077 putative substrate translocation pore; other site 991791000078 Isochorismatase family; Region: Isochorismatase; pfam00857 991791000079 Cysteine hydrolases; This family contains amidohydrolases, like CSHase (N-carbamoylsarcosine amidohydrolase), involved in creatine metabolism and nicotinamidase, converting nicotinamide to nicotinic acid and ammonia in the pyridine nucleotide cycle. It...; Region: cysteine_hydrolases; cd00431 991791000080 catalytic triad [active] 991791000081 conserved cis-peptide bond; other site 991791000082 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 991791000083 dimerization interface [polypeptide binding]; other site 991791000084 putative DNA binding site [nucleotide binding]; other site 991791000085 putative Zn2+ binding site [ion binding]; other site 991791000086 Rhodanese Homology Domain (RHOD); an alpha beta fold domain found duplicated in the rhodanese protein. The cysteine containing enzymatically active version of the domain is also found in the Cdc25 class of protein phosphatases and a variety of proteins...; Region: RHOD; cd00158 991791000087 active site residue [active] 991791000088 Putative redox-active protein (C_GCAxxG_C_C); Region: C_GCAxxG_C_C; pfam09719 991791000089 Rhodanese Homology Domain (RHOD); an alpha beta fold domain found duplicated in the rhodanese protein. The cysteine containing enzymatically active version of the domain is also found in the Cdc25 class of protein phosphatases and a variety of proteins...; Region: RHOD; cd00158 991791000090 active site residue [active] 991791000091 bifunctional acetaldehyde-CoA/alcohol dehydrogenase; Provisional; Region: PRK13805 991791000092 Coenzyme A acylating aldehyde dehydrogenase (ACDH), ALDH family 20-like; Region: ALDH_F20_ACDH; cd07122 991791000093 putative catalytic cysteine [active] 991791000094 C-terminal alcohol dehydrogenase domain of the acetaldehyde dehydrogenase-alcohol dehydrogenase bifunctional two-domain protein (AAD); Region: AAD_C; cd08178 991791000095 putative active site [active] 991791000096 metal binding site [ion binding]; metal-binding site 991791000097 Polymer-forming cytoskeletal; Region: Bactofilin; pfam04519 991791000098 Integral membrane protein CcmA involved in cell shape determination [Cell envelope biogenesis, outer membrane]; Region: CcmA; COG1664 991791000099 Protein of unknown function (DUF4004); Region: DUF4004; pfam13171 991791000100 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2350 991791000101 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 991791000102 non-specific DNA binding site [nucleotide binding]; other site 991791000103 salt bridge; other site 991791000104 sequence-specific DNA binding site [nucleotide binding]; other site 991791000105 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 991791000106 binding surface 991791000107 TPR motif; other site 991791000108 Tetratricopeptide repeat; Region: TPR_12; pfam13424 991791000109 Predicted ferric reductase [Inorganic ion transport and metabolism]; Region: COG4097 991791000110 Ferric reductase like transmembrane component; Region: Ferric_reduct; pfam01794 991791000111 NAD(P) binding domain of ferredoxin reductase-like proteins catalyze electron transfer between an NAD(P)-binding sub-domain of the alpha/beta class and a discrete (usually N-terminal) domain, which varies in orientation with respect to the NAD(P)...; Region: FNR_like_3; cd06198 991791000112 FAD binding pocket [chemical binding]; other site 991791000113 FAD binding motif [chemical binding]; other site 991791000114 phosphate binding motif [ion binding]; other site 991791000115 beta-alpha-beta structure motif; other site 991791000116 NAD binding pocket [chemical binding]; other site 991791000117 This family includes the Gtfs, a group of homologous glycosyltransferases involved in the final stages of the biosynthesis of antibiotics vancomycin and related chloroeremomycin. Gtfs transfer sugar moieties from an activated NDP-sugar donor to the...; Region: GT1_Gtf_like; cd03784 991791000118 glycosyltransferase, MGT family; Region: MGT; TIGR01426 991791000119 active site 991791000120 TDP-binding site; other site 991791000121 acceptor substrate-binding pocket; other site 991791000122 homodimer interface [polypeptide binding]; other site 991791000123 probable dihydroxyacetone kinase regulator; Region: DHAK_reg; TIGR02366 991791000124 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 991791000125 Transcriptional regulator C-terminal region; Region: TetR_C_8; pfam14278 991791000126 Metal-dependent hydrolases of the beta-lactamase superfamily III [General function prediction only]; Region: ElaC; COG1234 991791000127 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 991791000128 dimer interface [polypeptide binding]; other site 991791000129 putative CheW interface [polypeptide binding]; other site 991791000130 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 991791000131 H+ Antiporter protein; Region: 2A0121; TIGR00900 991791000132 putative substrate translocation pore; other site 991791000133 Carboxylesterase type B [Lipid metabolism]; Region: PnbA; COG2272 991791000134 Esterases and lipases (includes fungal lipases, cholinesterases, etc.) These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cd00312 991791000135 substrate binding pocket [chemical binding]; other site 991791000136 catalytic triad [active] 991791000137 Short-chain dehydrogenases of various substrate specificities [General function prediction only]; Region: DltE; COG0300 991791000138 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 991791000139 NAD(P) binding site [chemical binding]; other site 991791000140 active site 991791000141 helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347 991791000142 MarR family; Region: MarR_2; pfam12802 991791000143 Beta-1,4-xylanase [Carbohydrate transport and metabolism]; Region: XynA; COG3693 991791000144 Predicted xylanase/chitin deacetylase [Carbohydrate transport and metabolism]; Region: CDA1; COG0726 991791000145 Putative catalytic NodB homology domain of PgaB, IcaB, and similar proteins which consist of a deformed (beta/alpha)8 barrel fold with 5- or 6-strands; Region: CE4_NodB_like_5s_6s; cd10918 991791000146 putative active site [active] 991791000147 putative metal binding site [ion binding]; other site 991791000148 CAAX protease self-immunity; Region: Abi; pfam02517 991791000149 parallel beta-helix repeat-containing protein; Region: beta_helix_1; TIGR03805 991791000150 Periplasmic component of the Tol biopolymer transport system [Intracellular trafficking and secretion]; Region: TolB; COG0823 991791000151 Lipoproteins [Cell envelope biogenesis, outer membrane]; Region: RlpA; COG0797 991791000152 Rare lipoprotein A (RlpA)-like double-psi beta-barrel; Region: DPBB_1; pfam03330 991791000153 Iron-containing alcohol dehydrogenases-like; Region: Fe-ADH5; cd08189 991791000154 Alcohol dehydrogenase, class IV [Energy production and conversion]; Region: EutG; COG1454 991791000155 putative active site [active] 991791000156 metal binding site [ion binding]; metal-binding site 991791000157 Chloramphenicol O-acetyltransferase [Defense mechanisms]; Region: COG4845 991791000158 Chloramphenicol acetyltransferase; Region: CAT; smart01059 991791000159 manganese transport protein MntH; Reviewed; Region: PRK00701 991791000160 Natural resistance-associated macrophage protein; Region: Nramp; pfam01566 991791000161 Fructose-1.6-bisphosphate aldolase found in gram +/- bacteria; Region: FBP_aldolase_I_bact; cd00949 991791000162 putative active site [active] 991791000163 catalytic residue [active] 991791000164 M6 family metalloprotease domain; Region: M6dom_TIGR03296 991791000165 Coagulation factor 5/8 C-terminal domain, discoidin domain; Cell surface-attached carbohydrate-binding domain, present in eukaryotes and assumed to have horizontally transferred to eubacterial genomes; Region: FA58C; cl12042 991791000166 PTS system mannose-specific transporter subunits IIAB; Provisional; Region: PRK15088 991791000167 PTS_IIA, PTS system, mannose/sorbose specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIA_man; cd00006 991791000168 active pocket/dimerization site; other site 991791000169 active site 991791000170 phosphorylation site [posttranslational modification] 991791000171 PTS_IIB, PTS system, Mannose/sorbose specific IIB subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIB_man; cd00001 991791000172 active site 991791000173 phosphorylation site [posttranslational modification] 991791000174 PTS system mannose-specific transporter subunit IIC; Provisional; Region: PRK15065 991791000175 Phosphotransferase system, mannose/fructose/N-acetylgalactosamine-specific component IID [Carbohydrate transport and metabolism]; Region: ManZ; COG3716 991791000176 Domain of unknown function (DUF956); Region: DUF956; pfam06115 991791000177 Cof subfamily of IIB subfamily of haloacid dehalogenase superfamily; Region: Cof-subfamily; TIGR00099 991791000178 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 991791000179 motif II; other site 991791000180 Enterochelin esterase and related enzymes [Inorganic ion transport and metabolism]; Region: Fes; COG2382 991791000181 Predicted hydrolase of the alpha/beta superfamily [General function prediction only]; Region: COG2819 991791000182 Ricin-type beta-trefoil lectin domain; Region: Ricin_B_lectin; pfam00652 991791000183 Ricin-type beta-trefoil; Carbohydrate-binding domain formed from presumed gene triplication. The domain is found in a variety of molecules serving diverse functions such as enzymatic activity, inhibitory toxicity and signal transduction. Highly specific...; Region: RICIN; cd00161 991791000184 putative sugar binding sites [chemical binding]; other site 991791000185 Q-X-W motif; other site 991791000186 ABC-type bacteriocin/lantibiotic exporters, contain an N-terminal double-glycine peptidase domain [Defense mechanisms]; Region: SunT; COG2274 991791000187 A sub-family of peptidase family C39. Peptidase family C39 mostly contains bacteriocin-processing endopeptidases from bacteria. The cysteine peptidases in family C39 cleave the "double-glycine" leader peptides from the precursors of various...; Region: Peptidase_C39B; cd02418 991791000188 putative active site [active] 991791000189 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 991791000190 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 991791000191 Walker A/P-loop; other site 991791000192 ATP binding site [chemical binding]; other site 991791000193 Q-loop/lid; other site 991791000194 ABC transporter signature motif; other site 991791000195 Walker B; other site 991791000196 D-loop; other site 991791000197 H-loop/switch region; other site 991791000198 type I secretion membrane fusion protein, HlyD family; Region: type_I_hlyD; TIGR01843 991791000199 Predicted membrane protein [Function unknown]; Region: COG2323 991791000200 glycosyltransferase; Provisional; Region: PRK13481 991791000201 Transglycosylase; Region: Transgly; pfam00912 991791000202 Uncharacterized Fe-S protein [Energy production and conversion]; Region: COG1600 991791000203 putative acyltransferase; Provisional; Region: PRK05790 991791000204 Thiolase are ubiquitous enzymes that catalyze the reversible thiolytic cleavage of 3-ketoacyl-CoA into acyl-CoA and acetyl-CoA, a 2-step reaction involving a covalent intermediate formed with a catalytic cysteine. They are found in prokaryotes and...; Region: thiolase; cd00751 991791000205 dimer interface [polypeptide binding]; other site 991791000206 active site 991791000207 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 991791000208 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 991791000209 site-specific tyrosine recombinase XerC; Reviewed; Region: xerC; PRK00236 991791000210 DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213 991791000211 active site 991791000212 DNA binding site [nucleotide binding] 991791000213 Int/Topo IB signature motif; other site 991791000214 Site-specific recombinases, DNA invertase Pin homologs [DNA replication, recombination, and repair]; Region: PinR; COG1961 991791000215 Serine Recombinase family, catalytic domain; a DNA binding domain may be present either N- or C-terminal to the catalytic domain. These enzymes perform site-specific recombination of DNA molecules by a concerted, four-strand cleavage and rejoining...; Region: Ser_Recombinase; cl02788 991791000216 cAMP-binding proteins - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases [Signal transduction mechanisms]; Region: Crp; COG0664 991791000217 effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038 991791000218 ligand binding site [chemical binding]; other site 991791000219 flexible hinge region; other site 991791000220 helix_turn_helix, cAMP Regulatory protein C-terminus; DNA binding domain of prokaryotic regulatory proteins belonging to the catabolite activator protein family; Region: HTH_CRP; cd00092 991791000221 putative switch regulator; other site 991791000222 non-specific DNA interactions [nucleotide binding]; other site 991791000223 DNA binding site [nucleotide binding] 991791000224 sequence specific DNA binding site [nucleotide binding]; other site 991791000225 putative cAMP binding site [chemical binding]; other site 991791000226 Methyltransferase domain; Region: Methyltransf_31; pfam13847 991791000227 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 991791000228 S-adenosylmethionine binding site [chemical binding]; other site 991791000229 Protein of unknown function (DUF1648); Region: DUF1648; pfam07853 991791000230 Major Facilitator Superfamily; Region: MFS_1; pfam07690 991791000231 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 991791000232 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 991791000233 beta-ketoacyl-acyl-carrier-protein synthase II; Region: fabF; TIGR03150 991791000234 Beta-ketoacyl-acyl carrier protein (ACP) synthase (KAS), type I and II. KASs are responsible for the elongation steps in fatty acid biosynthesis. KASIII catalyses the initial condensation and KAS I and II catalyze further elongation steps by Claisen...; Region: KAS_I_II; cd00834 991791000235 dimer interface [polypeptide binding]; other site 991791000236 active site 991791000237 ABC-2 family transporter protein; Region: ABC2_membrane_5; pfam13346 991791000238 ABC-type multidrug transport system, ATPase component [Defense mechanisms]; Region: CcmA; COG1131 991791000239 ATP-binding cassette domain of the drug resistance transporter and related proteins, subfamily A; Region: ABC_DR_subfamily_A; cd03230 991791000240 Walker A/P-loop; other site 991791000241 ATP binding site [chemical binding]; other site 991791000242 Q-loop/lid; other site 991791000243 ABC transporter signature motif; other site 991791000244 Walker B; other site 991791000245 D-loop; other site 991791000246 H-loop/switch region; other site 991791000247 Regulators of stationary/sporulation gene expression [Transcription]; Region: AbrB; COG2002 991791000248 looped-hinge helix DNA binding domain, AbrB family; Region: lp_hng_hel_AbrB; TIGR01439 991791000249 Tn3 transposase DDE domain; Region: DDE_Tnp_Tn3; pfam01526 991791000250 Transposase and inactivated derivatives, TnpA family [DNA replication, recombination, and repair]; Region: COG4644 991791000251 Inorganic pyrophosphatase [Energy production and conversion]; Region: Ppa; COG0221 991791000252 dimer interface [polypeptide binding]; other site 991791000253 Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596 991791000254 homoserine O-acetyltransferase; Provisional; Region: metX; cl17114 991791000255 TAP-like protein; Region: Abhydrolase_4; pfam08386 991791000256 Glycosidases [Carbohydrate transport and metabolism]; Region: AmyA; COG0366 991791000257 Alpha amylase catalytic domain found in bacterial Alpha-amylases (also called 1,4-alpha-D-glucan-4-glucanohydrolase); Region: AmyAc_bac1_AmyA; cd11315 991791000258 active site 991791000259 Ca binding site [ion binding]; other site 991791000260 catalytic site [active] 991791000261 Aamy_C domain; Region: Aamy_C; smart00632 991791000262 Carbohydrate binding domain (family 25); Region: CBM_25; cl04060 991791000263 DNA-binding domain of DNA mismatch repair MUTS family; Region: MUTSd; smart00533 991791000264 MutS domain III; Region: MutS_III; pfam05192 991791000265 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 991791000266 Walker A/P-loop; other site 991791000267 ATP binding site [chemical binding]; other site 991791000268 Q-loop/lid; other site 991791000269 ABC transporter signature motif; other site 991791000270 Walker B; other site 991791000271 D-loop; other site 991791000272 H-loop/switch region; other site 991791000273 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 991791000274 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 991791000275 Uncharacterized protein involved in formate dehydrogenase formation [Posttranslational modification, protein turnover, chaperones]; Region: FdhE; COG3058 991791000276 Predicted drug exporters of the RND superfamily [General function prediction only]; Region: COG2409 991791000277 CLC voltage-gated chloride channel. The ClC chloride channels catalyse the selective flow of Cl- ions across cell membranes, thereby regulating electrical excitation in skeletal muscle and the flow of salt and water across epithelial barriers. This...; Region: Voltage_gated_ClC; cl02915 991791000278 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 991791000279 dimerization interface [polypeptide binding]; other site 991791000280 putative DNA binding site [nucleotide binding]; other site 991791000281 putative Zn2+ binding site [ion binding]; other site 991791000282 Arsenite efflux pump ACR3 and related permeases [Inorganic ion transport and metabolism]; Region: ACR3; COG0798 991791000283 arsenical-resistance protein; Region: acr3; TIGR00832 991791000284 Protein-tyrosine-phosphatase [Signal transduction mechanisms]; Region: Wzb; COG0394 991791000285 Low molecular weight phosphatase family; Region: LMWPc; cd00115 991791000286 active site 991791000287 1-deoxy-D-xylulose-5-phosphate synthase; Provisional; Region: PRK12315 991791000288 Thiamine pyrophosphate (TPP) family, DXS subfamily, TPP-binding module; 1-Deoxy-D-xylulose-5-phosphate synthase (DXS) is a regulatory enzyme of the mevalonate-independent pathway involved in terpenoid biosynthesis. Terpeniods are plant natural products...; Region: TPP_DXS; cd02007 991791000289 TPP-binding site; other site 991791000290 Pyrimidine (PYR) binding domain of 1-deoxy-D-xylulose-5-phosphate synthase (DXS), transketolase (TK), and related proteins; Region: TPP_PYR_DXS_TK_like; cd07033 991791000291 PYR/PP interface [polypeptide binding]; other site 991791000292 dimer interface [polypeptide binding]; other site 991791000293 TPP binding site [chemical binding]; other site 991791000294 Transketolase, C-terminal domain; Region: Transketolase_C; pfam02780 991791000295 Predicted transcriptional regulators [Transcription]; Region: SoxR; COG0789 991791000296 Helix-Turn-Helix DNA binding domain of the MerR-like transcription regulators YyaN and YraB; Region: HTH_YyaN; cd01109 991791000297 DNA binding residues [nucleotide binding] 991791000298 putative dimer interface [polypeptide binding]; other site 991791000299 Predicted transcriptional regulators [Transcription]; Region: COG1695 991791000300 Winged helix DNA-binding domain; Region: HTH_34; pfam13601 991791000301 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 991791000302 Major Facilitator Superfamily; Region: MFS_1; pfam07690 991791000303 putative substrate translocation pore; other site 991791000304 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 991791000305 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 991791000306 Coenzyme A binding pocket [chemical binding]; other site 991791000307 Acetyltransferases [General function prediction only]; Region: RimI; COG0456 991791000308 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 991791000309 Coenzyme A binding pocket [chemical binding]; other site 991791000310 Solo B3/4 domain (OB-fold DNA/RNA-binding) of Phe-aaRS-beta [General function prediction only]; Region: COG3382 991791000311 B3/4 domain; Region: B3_4; pfam03483 991791000312 Beta-xylosidase [Carbohydrate transport and metabolism]; Region: XynB; COG3507 991791000313 Glycosyl hydrolase family 43, beta-D-xylosidase; Region: GH43_XYL_2; cd09001 991791000314 active site 991791000315 Glycosyl hydrolase family 43, includes arabinoxylan arabinofuranohydrolase, beta-xylosidase, endo-1,4-beta-xylanase, alpha-L-arabinofuranosidase; Region: GH43_AXH_like; cd08990 991791000316 substrate binding site [chemical binding]; other site 991791000317 active site 991791000318 Carbohydrate Binding Module 6 (CBM6); many are appended to glycoside hydrolase (GH) family 11 and GH43 xylanase domains; Region: CBM6_xylanase-like; cd04084 991791000319 metal binding site [ion binding]; metal-binding site 991791000320 ligand binding site [chemical binding]; other site 991791000321 Beta-1,4-xylanase [Carbohydrate transport and metabolism]; Region: XynA; COG3693 991791000322 Glycosyl hydrolases family 39; Region: Glyco_hydro_39; pfam01229 991791000323 O-Glycosyl hydrolase [Cell envelope biogenesis, outer membrane]; Region: COG5520 991791000324 O-Glycosyl hydrolase family 30; Region: Glyco_hydro_30; pfam02055 991791000325 Ricin-type beta-trefoil; Carbohydrate-binding domain formed from presumed gene triplication. The domain is found in a variety of molecules serving diverse functions such as enzymatic activity, inhibitory toxicity and signal transduction. Highly specific...; Region: RICIN; cd00161 991791000326 Ricin-type beta-trefoil lectin domain; Region: Ricin_B_lectin; pfam00652 991791000327 putative sugar binding sites [chemical binding]; other site 991791000328 Q-X-W motif; other site 991791000329 O-Glycosyl hydrolase [Cell envelope biogenesis, outer membrane]; Region: COG5520 991791000330 O-Glycosyl hydrolase family 30; Region: Glyco_hydro_30; pfam02055 991791000331 Ricin-type beta-trefoil; Carbohydrate-binding domain formed from presumed gene triplication. The domain is found in a variety of molecules serving diverse functions such as enzymatic activity, inhibitory toxicity and signal transduction. Highly specific...; Region: RICIN; cd00161 991791000332 Ricin-type beta-trefoil lectin domain; Region: Ricin_B_lectin; pfam00652 991791000333 putative sugar binding sites [chemical binding]; other site 991791000334 Q-X-W motif; other site 991791000335 Glycosyl hydrolase family 43; Region: GH43_AXH_1; cd09003 991791000336 substrate binding site [chemical binding]; other site 991791000337 active site 991791000338 Carbohydrate Binding Module 6 (CBM6); many are appended to glycoside hydrolase (GH) family 11 and GH43 xylanase domains; Region: CBM6_xylanase-like; cd04084 991791000339 metal binding site [ion binding]; metal-binding site 991791000340 ligand binding site [chemical binding]; other site 991791000341 Ricin-type beta-trefoil lectin domain; Region: Ricin_B_lectin; pfam00652 991791000342 Ricin-type beta-trefoil; Carbohydrate-binding domain formed from presumed gene triplication. The domain is found in a variety of molecules serving diverse functions such as enzymatic activity, inhibitory toxicity and signal transduction. Highly specific...; Region: RICIN; cd00161 991791000343 putative sugar binding sites [chemical binding]; other site 991791000344 Q-X-W motif; other site 991791000345 Regulator of polyketide synthase expression [Signal transduction mechanisms / Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG2508 991791000346 GAF domain; Region: GAF; cl17456 991791000347 PucR C-terminal helix-turn-helix domain; Region: HTH_30; pfam13556 991791000348 dTDP-4-dehydrorhamnose reductase [Cell envelope biogenesis, outer membrane]; Region: RfbD; COG1091 991791000349 dTDP-6-deoxy-L-lyxo-4-hexulose reductase and related proteins, extended (e) SDRs; Region: dTDP_HR_like_SDR_e; cd05254 991791000350 NADP binding site [chemical binding]; other site 991791000351 active site 991791000352 putative substrate binding site [chemical binding]; other site 991791000353 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 991791000354 Major Facilitator Superfamily; Region: MFS_1; pfam07690 991791000355 putative substrate translocation pore; other site 991791000356 Plasmid segregation protein ParM and similar proteins; Region: ParM_like; cd10227 991791000357 Mg binding site [ion binding]; other site 991791000358 nucleotide binding site [chemical binding]; other site 991791000359 putative protofilament interface [polypeptide binding]; other site 991791000360 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 991791000361 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 991791000362 drug resistance transporter, EmrB/QacA subfamily; Region: efflux_EmrB; TIGR00711 991791000363 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 991791000364 putative substrate translocation pore; other site 991791000365 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 991791000366 Putative phosphatase regulatory subunit; Region: CBM_21; pfam03370 991791000367 Putative phosphatase regulatory subunit; Region: CBM_21; pfam03370 991791000368 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 991791000369 putative substrate translocation pore; other site 991791000370 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 991791000371 Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596 991791000372 Predicted hydrolase of the alpha/beta superfamily [General function prediction only]; Region: COG2819 991791000373 Condensing enzymes; Family of enzymes that catalyze a (decarboxylating or non-decarboxylating) Claisen-like condensation reaction. Members are share strong structural similarity, and are involved in the synthesis and degradation of fatty acids, and the...; Region: cond_enzymes; cl09938 991791000374 active site 991791000375 Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673 991791000376 Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408 991791000377 Oxidoreductase family, C-terminal alpha/beta domain; Region: GFO_IDH_MocA_C; pfam02894 991791000378 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 991791000379 Radical SAM superfamily; Region: Radical_SAM; pfam04055 991791000380 FeS/SAM binding site; other site 991791000381 Domain of unknown function (DUF4008); Region: DUF4008; pfam13186 991791000382 UDP-N-acetylglucosamine:LPS N-acetylglucosamine transferase [Cell envelope biogenesis, outer membrane]; Region: MurG; COG0707 991791000383 acetyl-CoA carboxylase subunit A; Validated; Region: PRK08463 991791000384 phosphoribosylamine--glycine ligase; Region: purD; TIGR00877 991791000385 Acyl carrier protein [Lipid metabolism / Secondary metabolites biosynthesis, transport, and catabolism]; Region: AcpP; COG0236 991791000386 Na+/H+ antiporter [Energy production and conversion]; Region: NhaC; COG1757 991791000387 Ni,Fe-hydrogenase I small subunit [Energy production and conversion]; Region: HyaA; COG1740 991791000388 NADH ubiquinone oxidoreductase, 20 Kd subunit; Region: Oxidored_q6; pfam01058 991791000389 Ni,Fe-hydrogenase I large subunit [Energy production and conversion]; Region: HyaB; COG0374 991791000390 Nickel-dependent hydrogenase; Region: NiFeSe_Hases; pfam00374 991791000391 coenzyme F420-reducing hydrogenase delta subunit (putative coenzyme F420 hydrogenase processing subunit); Region: frhD; TIGR00130 991791000392 Hydrogenase specific C-terminal endopeptidases, also called Hydrogen Maturation Proteases (H2MP). These enzymes belong to the peptidase family M52. Maturation of [FeNi] hydrogenases includes formation of the nickel metallocenter, proteolytic processing...; Region: H2MP; cd00518 991791000393 nickel binding site [ion binding]; other site 991791000394 Predicted heme/steroid binding protein [General function prediction only]; Region: COG4892 991791000395 Hydrogenase maturation factor [Posttranslational modification, protein turnover, chaperones]; Region: HypF; COG0068 991791000396 HypF finger; Region: zf-HYPF; pfam07503 991791000397 Telomere recombination; Region: Sua5_yciO_yrdC; pfam01300 991791000398 Hydrogenase maturation factor [Posttranslational modification, protein turnover, chaperones]; Region: HypF; COG0068 991791000399 Predicted membrane protein [Function unknown]; Region: COG2323 991791000400 Zinc dependent phospholipase C (alpha toxin); Region: Zn_dep_PLPC; cd11009 991791000401 Zn binding site [ion binding]; other site 991791000402 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 991791000403 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 991791000404 non-specific DNA binding site [nucleotide binding]; other site 991791000405 salt bridge; other site 991791000406 sequence-specific DNA binding site [nucleotide binding]; other site 991791000407 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 991791000408 binding surface 991791000409 TPR motif; other site 991791000410 Cell division protein FtsI/penicillin-binding protein 2 [Cell envelope biogenesis, outer membrane]; Region: FtsI; COG0768 991791000411 Penicillin-binding Protein dimerisation domain; Region: PBP_dimer; pfam03717 991791000412 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; pfam00905 991791000413 Family description; Region: VCBS; pfam13517 991791000414 Family description; Region: VCBS; pfam13517 991791000415 Family description; Region: VCBS; pfam13517 991791000416 Family description; Region: VCBS; pfam13517 991791000417 Family description; Region: VCBS; pfam13517 991791000418 Endolysins and autolysins are found in viruses and bacteria, respectively. The ds DNA phages of eubacteria use endolysins or muralytic enzymes in conjunction with hollin, a small membrane protein, to degrade the peptidoglycan found in bacterial cell...; Region: endolysin_autolysin; cd00737 991791000419 catalytic residues [active] 991791000420 Predicted transcriptional regulators [Transcription]; Region: COG1695 991791000421 Transcriptional regulator PadR-like family; Region: PadR; pfam03551 991791000422 Protein of unknown function (DUF1048); Region: DUF1048; cl01986 991791000423 RNA polymerase sigma factor, sigma-70 family; Region: sigma70-ECF; TIGR02937 991791000424 Bacterial surface proteins containing Ig-like domains [Cell motility and secretion]; Region: COG5492 991791000425 Bacterial Ig-like domain (group 2); Region: Big_2; pfam02368 991791000426 Bacterial surface proteins containing Ig-like domains [Cell motility and secretion]; Region: COG5492 991791000427 Bacterial Ig-like domain (group 2); Region: Big_2; pfam02368 991791000428 Bacterial surface proteins containing Ig-like domains [Cell motility and secretion]; Region: COG5492 991791000429 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 991791000430 binding surface 991791000431 TPR motif; other site 991791000432 TPR repeat; Region: TPR_11; pfam13414 991791000433 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 991791000434 binding surface 991791000435 TPR motif; other site 991791000436 Tetratricopeptide repeat; Region: TPR_12; pfam13424 991791000437 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 991791000438 binding surface 991791000439 TPR repeat; Region: TPR_11; pfam13414 991791000440 TPR motif; other site 991791000441 bifunctional acetaldehyde-CoA/alcohol dehydrogenase; Provisional; Region: PRK13805 991791000442 Coenzyme A acylating aldehyde dehydrogenase (ACDH), Ethanolamine utilization protein EutE, and related proteins; Region: ALDH_F20_ACDH_EutE-like; cd07081 991791000443 putative catalytic cysteine [active] 991791000444 C-terminal alcohol dehydrogenase domain of the acetaldehyde dehydrogenase-alcohol dehydrogenase bifunctional two-domain protein (AAD); Region: AAD_C; cd08178 991791000445 putative active site [active] 991791000446 metal binding site [ion binding]; metal-binding site 991791000447 Acyl CoA:acetate/3-ketoacid CoA transferase, alpha subunit [Lipid metabolism]; Region: AtoD; COG1788 991791000448 3-oxoacid CoA-transferase, B subunit; Region: pcaJ_scoB_fam; TIGR02428 991791000449 acetoacetate decarboxylase; Provisional; Region: PRK02265 991791000450 YvrJ protein family; Region: YvrJ; pfam12841 991791000451 RNA polymerase sigma factor, sigma-70 family; Region: sigma70-ECF; TIGR02937 991791000452 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 991791000453 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cl17257 991791000454 DNA binding residues [nucleotide binding] 991791000455 Alpha amylase catalytic domain found in bacterial Alpha-amylases (also called 1,4-alpha-D-glucan-4-glucanohydrolase); Region: AmyAc_bac1_AmyA; cd11315 991791000456 Glycosidases [Carbohydrate transport and metabolism]; Region: AmyA; COG0366 991791000457 active site 991791000458 Ca binding site [ion binding]; other site 991791000459 catalytic site [active] 991791000460 Aamy_C domain; Region: Aamy_C; smart00632 991791000461 Carbohydrate binding domain (family 25); Region: CBM_25; cl04060 991791000462 Carbohydrate binding domain (family 25); Region: CBM_25; cl04060 991791000463 Carbohydrate binding domain (family 25); Region: CBM_25; cl04060 991791000464 Protein of unknown function (DUF2922); Region: DUF2922; pfam11148 991791000465 Protein of unknown function (DUF2922); Region: DUF2922; pfam11148 991791000466 Predicted Fe-S oxidoreductase [General function prediction only]; Region: COG1244 991791000467 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 991791000468 FeS/SAM binding site; other site 991791000469 Uncharacterized conserved protein [Function unknown]; Region: COG2898 991791000470 Protein involved in initiation of plasmid replication [DNA replication, recombination, and repair]; Region: COG5527 991791000471 Initiator Replication protein; Region: Rep_3; pfam01051 991791000472 Ribbon-helix-helix protein, copG family; Region: RHH_1; pfam01402 991791000473 ATPases involved in chromosome partitioning [Cell division and chromosome partitioning]; Region: Soj; COG1192 991791000474 ParA and ParB of Caulobacter crescentus belong to a conserved family of bacterial proteins implicated in chromosome segregation. ParB binds to DNA sequences adjacent to the origin of replication and localizes to opposite cell poles shortly following the...; Region: ParA; cd02042 991791000475 P-loop; other site 991791000476 Magnesium ion binding site [ion binding]; other site 991791000477 Predicted transcriptional regulators [Transcription]; Region: SoxR; COG0789 991791000478 Helix-Turn-Helix DNA binding domain of the MerR-like transcription regulators YyaN and YraB; Region: HTH_YyaN; cd01109 991791000479 DNA binding residues [nucleotide binding] 991791000480 putative dimer interface [polypeptide binding]; other site 991791000481 chromosomal replication initiation protein; Reviewed; Region: dnaA; PRK00149 991791000482 DnaA N-terminal domain; Region: DnaA_N; pfam11638 991791000483 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 991791000484 Walker A motif; other site 991791000485 ATP binding site [chemical binding]; other site 991791000486 Walker B motif; other site 991791000487 arginine finger; other site 991791000488 C-terminal domain of bacterial DnaA proteins. The DNA-binding C-terminal domain of DnaA contains a helix-turn-helix motif that specifically interacts with the DnaA box, a 9-mer motif that occurs repetitively in the replication origin oriC. Multiple...; Region: Bac_DnaA_C; cd06571 991791000489 DnaA box-binding interface [nucleotide binding]; other site 991791000490 DNA polymerase III subunit beta; Validated; Region: PRK05643 991791000491 Beta clamp domain. The beta subunit (processivity factor) of DNA polymerase III holoenzyme, refered to as the beta clamp, forms a ring shaped dimer that encircles dsDNA (sliding clamp) in bacteria. The beta-clamp is structurally similar to the trimeric...; Region: beta_clamp; cd00140 991791000492 putative DNA binding surface [nucleotide binding]; other site 991791000493 dimer interface [polypeptide binding]; other site 991791000494 beta-clamp/clamp loader binding surface; other site 991791000495 beta-clamp/translesion DNA polymerase binding surface; other site 991791000496 S4-like RNA binding protein [Replication, recombination, and repair]; Region: COG2501 991791000497 Recombinational DNA repair ATPase (RecF pathway) [DNA replication, recombination, and repair]; Region: RecF; COG1195 991791000498 ATP-binding cassette domain of RecF; Region: ABC_RecF; cd03242 991791000499 Walker A/P-loop; other site 991791000500 ATP binding site [chemical binding]; other site 991791000501 Q-loop/lid; other site 991791000502 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 991791000503 ABC transporter signature motif; other site 991791000504 Walker B; other site 991791000505 D-loop; other site 991791000506 H-loop/switch region; other site 991791000507 DNA gyrase subunit B; Validated; Region: gyrB; PRK05644 991791000508 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 991791000509 ATP binding site [chemical binding]; other site 991791000510 Mg2+ binding site [ion binding]; other site 991791000511 G-X-G motif; other site 991791000512 TopoIIA_Trans_DNA_gyrase: Transducer domain, having a ribosomal S5 domain 2-like fold, of the type found in proteins of the type IIA family of DNA topoisomerases similar to the B subunits of E. coli DNA gyrase and E. coli Topoisomerase IV which are; Region: TopoII_Trans_DNA_gyrase; cd00822 991791000513 anchoring element; other site 991791000514 dimer interface [polypeptide binding]; other site 991791000515 ATP binding site [chemical binding]; other site 991791000516 TOPRIM_TopoIIA_GyrB: topoisomerase-primase (TOPRIM) nucleotidyl transferase/hydrolase domain of the type found in proteins of the type IIA family of DNA topoisomerases similar to the Escherichia coli GyrB subunit. TopoIIA enzymes cut both strands of the...; Region: TOPRIM_TopoIIA_GyrB; cd03366 991791000517 active site 991791000518 putative metal-binding site [ion binding]; other site 991791000519 DNA gyrase B subunit, carboxyl terminus; Region: DNA_gyraseB_C; pfam00986 991791000520 DNA gyrase subunit A; Validated; Region: PRK05560 991791000521 DNA Topoisomerase, subtype IIA; domain A'; bacterial DNA topoisomerase IV (C subunit, ParC), bacterial DNA gyrases (A subunit, GyrA),mammalian DNA toposiomerases II. DNA topoisomerases are essential enzymes that regulate the conformational changes...; Region: TOP4c; cd00187 991791000522 CAP-like domain; other site 991791000523 active site 991791000524 primary dimer interface [polypeptide binding]; other site 991791000525 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 991791000526 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 991791000527 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 991791000528 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 991791000529 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 991791000530 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 991791000531 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cl17215 991791000532 Predicted small molecule binding protein (contains 3H domain) [General function prediction only]; Region: COG1827 991791000533 HTH domain; Region: HTH_11; pfam08279 991791000534 3H domain; Region: 3H; pfam02829 991791000535 hypothetical protein; Validated; Region: PRK00068 991791000536 Uncharacterized conserved protein [Function unknown]; Region: COG1615 991791000537 Uncharacterized protein conserved in bacteria [Function unknown]; Region: ErfK; COG1376 991791000538 L,D-transpeptidase catalytic domain; Region: YkuD; pfam03734 991791000539 Predicted dehydrogenase [General function prediction only]; Region: COG0579 991791000540 hydroxyglutarate oxidase; Provisional; Region: PRK11728 991791000541 BFD-like [2Fe-2S] binding domain; Region: Fer2_BFD; pfam04324 991791000542 Uncharacterized protein with conserved CXXC pairs [Function unknown]; Region: COG3862 991791000543 Serine-pyruvate aminotransferase/archaeal aspartate aminotransferase [Amino acid transport and metabolism]; Region: COG0075 991791000544 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 991791000545 catalytic residue [active] 991791000546 Phosphoglycerate dehydrogenase and related dehydrogenases [Amino acid transport and metabolism]; Region: SerA; COG0111 991791000547 Phosphoglycerate dehydrogenase (PGDH) NAD-binding and catalytic domains; Region: PGDH_2; cd05303 991791000548 putative ligand binding site [chemical binding]; other site 991791000549 NAD binding site [chemical binding]; other site 991791000550 dimerization interface [polypeptide binding]; other site 991791000551 catalytic site [active] 991791000552 Uncharacterized conserved protein [Function unknown]; Region: COG4198 991791000553 Protein of unknown function (DUF1015); Region: DUF1015; pfam06245 991791000554 seryl-tRNA synthetase; Provisional; Region: PRK05431 991791000555 Seryl-tRNA synthetase N-terminal domain; Region: Seryl_tRNA_N; pfam02403 991791000556 Seryl-tRNA synthetase (SerRS) class II core catalytic domain. SerRS is responsible for the attachment of serine to the 3' OH group of ribose of the appropriate tRNA. This domain It is primarily responsible for ATP-dependent formation of the enzyme...; Region: SerRS_core; cd00770 991791000557 dimer interface [polypeptide binding]; other site 991791000558 active site 991791000559 motif 1; other site 991791000560 motif 2; other site 991791000561 motif 3; other site 991791000562 Putative NADPH-quinone reductase (modulator of drug activity B) [General function prediction only]; Region: MdaB; COG2249 991791000563 NADPH-dependent FMN reductase; Region: FMN_red; pfam03358 991791000564 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 991791000565 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 991791000566 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 991791000567 Major Facilitator Superfamily; Region: MFS_1; pfam07690 991791000568 putative substrate translocation pore; other site 991791000569 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 991791000570 Predicted membrane protein [Function unknown]; Region: COG1511 991791000571 seryl-tRNA synthetase; Provisional; Region: PRK05431 991791000572 Seryl-tRNA synthetase N-terminal domain; Region: Seryl_tRNA_N; pfam02403 991791000573 Seryl-tRNA synthetase (SerRS) class II core catalytic domain. SerRS is responsible for the attachment of serine to the 3' OH group of ribose of the appropriate tRNA. This domain It is primarily responsible for ATP-dependent formation of the enzyme...; Region: SerRS_core; cd00770 991791000574 dimer interface [polypeptide binding]; other site 991791000575 active site 991791000576 motif 1; other site 991791000577 motif 2; other site 991791000578 motif 3; other site 991791000579 aspartate-semialdehyde dehydrogenase; Reviewed; Region: PRK08664 991791000580 Semialdehyde dehydrogenase, NAD binding domain; Region: Semialdhyde_dh; smart00859 991791000581 Glyceraldehyde 3-phosphate dehydrogenase, C-terminal domain; Region: Gp_dh_C; pfam02800 991791000582 Transcriptional regulator [Transcription]; Region: LysR; COG0583 991791000583 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 991791000584 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cd05466 991791000585 dimerization interface [polypeptide binding]; other site 991791000586 Predicted membrane protein [Function unknown]; Region: COG4713 991791000587 Trimeric dUTP diphosphatases; Region: trimeric_dUTPase; cd07557 991791000588 trimer interface [polypeptide binding]; other site 991791000589 active site 991791000590 Alpha/beta hydrolase family; Region: Abhydrolase_5; pfam12695 991791000591 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 991791000592 active site 991791000593 bidirectional hydrogenase complex protein HoxU; Validated; Region: PRK07569 991791000594 2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207 991791000595 catalytic loop [active] 991791000596 iron binding site [ion binding]; other site 991791000597 [FeFe] hydrogenase, group A; Region: FeFe_hydrog_A; TIGR02512 991791000598 Iron only hydrogenase large subunit, C-terminal domain; Region: Fe_hyd_lg_C; pfam02906 991791000599 Iron hydrogenase small subunit; Region: Fe_hyd_SSU; pfam02256 991791000600 Uncharacterized distant relative of cell wall-associated hydrolases [Function unknown]; Region: COG3863 991791000601 phosphatidylserine decarboxylase; Provisional; Region: PRK00723 991791000602 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 991791000603 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 991791000604 YsiA-like protein, C-terminal region; Region: TetR_C_4; pfam08359 991791000605 2-polyprenylphenol 6-hydroxylase; Region: UbiB; TIGR01982 991791000606 ABC1 family; Region: ABC1; cl17513 991791000607 Uncharacterized conserved protein [Function unknown]; Region: COG3937 991791000608 Serine/threonine phosphatases, family 2C, catalytic domain; The protein architecture and deduced catalytic mechanism of PP2C phosphatases are similar to the PP1, PP2A, PP2B family of protein Ser/Thr phosphatases, with which PP2C shares no sequence...; Region: PP2Cc; cd00143 991791000609 active site 991791000610 FOG: FHA domain [Signal transduction mechanisms]; Region: COG1716 991791000611 Forkhead associated domain (FHA); found in eukaryotic and prokaryotic proteins. Putative nuclear signalling domain. FHA domains may bind phosphothreonine, phosphoserine and sometimes phosphotyrosine. In eukaryotes, many FHA domain-containing proteins...; Region: FHA; cd00060 991791000612 phosphopeptide binding site; other site 991791000613 AAA domain; Region: AAA_31; pfam13614 991791000614 The Fer4_NifH superfamily contains a variety of proteins which share a common ATP-binding domain. Functionally, proteins in this superfamily use the energy from hydrolysis of NTP to transfer electron or ion; Region: Fer4_NifH; cl17203 991791000615 WXG100 protein secretion system (Wss), protein YukD; Region: YukD; pfam08817 991791000616 FOG: FHA domain [Signal transduction mechanisms]; Region: COG1716 991791000617 Forkhead associated domain (FHA); found in eukaryotic and prokaryotic proteins. Putative nuclear signalling domain. FHA domains may bind phosphothreonine, phosphoserine and sometimes phosphotyrosine. In eukaryotes, many FHA domain-containing proteins...; Region: FHA; cd00060 991791000618 phosphopeptide binding site; other site 991791000619 type VII secretion protein EssC, C-terminal domain; Region: T7_EssCb_Firm; TIGR03928 991791000620 FtsK/SpoIIIE family; Region: FtsK_SpoIIIE; pfam01580 991791000621 FtsK/SpoIIIE family; Region: FtsK_SpoIIIE; pfam01580 991791000622 FtsK/SpoIIIE family; Region: FtsK_SpoIIIE; pfam01580 991791000623 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4842 991791000624 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4842 991791000625 TPR repeat; Region: TPR_11; pfam13414 991791000626 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 991791000627 binding surface 991791000628 TPR motif; other site 991791000629 TPR repeat; Region: TPR_11; pfam13414 991791000630 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 991791000631 binding surface 991791000632 TPR motif; other site 991791000633 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 991791000634 binding surface 991791000635 TPR motif; other site 991791000636 WXG100 family type VII secretion target; Region: WXG100_ESAT6; TIGR03930 991791000637 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4332 991791000638 Prophage tail length tape measure protein; Region: TMP_2; pfam06791 991791000639 Phage-related protein [Function unknown]; Region: COG4722 991791000640 putative phage tail component, N-terminal domain; Region: phi3626_gp14_N; TIGR01633 991791000641 Phage-related protein [Function unknown]; Region: PblB; COG4926 991791000642 Prophage endopeptidase tail; Region: Prophage_tail; cl12123 991791000643 ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136 991791000644 ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255 991791000645 Walker A/P-loop; other site 991791000646 ATP binding site [chemical binding]; other site 991791000647 Q-loop/lid; other site 991791000648 ABC transporter signature motif; other site 991791000649 Walker B; other site 991791000650 D-loop; other site 991791000651 H-loop/switch region; other site 991791000652 FtsX-like permease family; Region: FtsX; pfam02687 991791000653 ABC-type antimicrobial peptide transport system, permease component [Defense mechanisms]; Region: SalY; COG0577 991791000654 Hemerythrin; Region: Hemerythrin; cd12107 991791000655 Fe binding site [ion binding]; other site 991791000656 Domain of unknown function (DUF4163); Region: DUF4163; pfam13739 991791000657 Regulator of cell morphogenesis and NO signaling [Cell division and chromosome partitioning]; Region: COG2846 991791000658 Domain of Unknown function (DUF542); Region: ScdA_N; pfam04405 991791000659 Hemerythrin HHE cation binding domain; Region: Hemerythrin; pfam01814 991791000660 Uncharacterized conserved protein [Function unknown]; Region: COG4309 991791000661 Pentapeptide repeats containing protein [Function unknown]; Region: COG1357 991791000662 Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805 991791000663 Cysteine-rich 4 helical bundle widely conserved in bacteria; Region: DUF326; cd08026 991791000664 dimerization interface [polypeptide binding]; other site 991791000665 Permeases of the drug/metabolite transporter (DMT) superfamily [Carbohydrate transport and metabolism / Amino acid transport and metabolism / General function prediction only]; Region: RhaT; COG0697 991791000666 EamA-like transporter family; Region: EamA; pfam00892 991791000667 EamA-like transporter family; Region: EamA; pfam00892 991791000668 CAAX protease self-immunity; Region: Abi; pfam02517 991791000669 putative accessory gene regulator protein; Provisional; Region: PRK01100 991791000670 cyclic lactone autoinducer peptide; Region: quorum_AgrD; TIGR04223 991791000671 Predicted signal transduction protein with a C-terminal ATPase domain [Signal transduction mechanisms]; Region: COG2972 991791000672 Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase; Region: HATPase_c; pfam02518 991791000673 Response regulator of the LytR/AlgR family [Transcription / Signal transduction mechanisms]; Region: LytT; COG3279 991791000674 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 991791000675 active site 991791000676 phosphorylation site [posttranslational modification] 991791000677 intermolecular recognition site; other site 991791000678 dimerization interface [polypeptide binding]; other site 991791000679 LytTr DNA-binding domain; Region: LytTR; pfam04397 991791000680 LanC-like proteins. LanC is the cyclase enzyme of the lanthionine synthetase. Lanthionine is a lantibiotic, a unique class of peptide antibiotics. They are ribosomally synthesized as a precursor peptide and then post-translationally modified to contain...; Region: LanC_like; cl04955 991791000681 Lanthionine synthetase C-like protein; Region: LANC_like; pfam05147 991791000682 active site 991791000683 zinc binding site [ion binding]; other site 991791000684 Growth inhibitor [Signal transduction mechanisms]; Region: MazF; COG2337 991791000685 MutT homolog-1 (MTH1) is a member of the Nudix hydrolase superfamily. MTH1, the mammalian counterpart of MutT, hydrolyzes oxidized purine nucleoside triphosphates, such as 8-oxo-dGTP and 2-hydroxy-ATP, to monophosphates, thereby preventing the...; Region: MTH1; cd03427 991791000686 putative active site [active] 991791000687 nucleotide binding site [chemical binding]; other site 991791000688 nudix motif; other site 991791000689 putative metal binding site [ion binding]; other site 991791000690 3-carboxymuconate cyclase [Carbohydrate transport and metabolism]; Region: COG2706 991791000691 Predicted Co/Zn/Cd cation transporters [Inorganic ion transport and metabolism]; Region: MMT1; COG0053 991791000692 cation diffusion facilitator family transporter; Region: CDF; TIGR01297 991791000693 methionine sulfoxide reductase A; Provisional; Region: PRK14054 991791000694 Phosphoglycerate dehydrogenase and related dehydrogenases [Amino acid transport and metabolism]; Region: SerA; COG0111 991791000695 Putative glycerate dehydrogenase and related proteins of the D-specific 2-hydroxy dehydrogenase family; Region: GDH_like_1; cd12161 991791000696 putative ligand binding site [chemical binding]; other site 991791000697 putative NAD binding site [chemical binding]; other site 991791000698 catalytic site [active] 991791000699 Predicted xylanase/chitin deacetylase [Carbohydrate transport and metabolism]; Region: CDA1; COG0726 991791000700 Catalytic NodB homology domain of Streptococcus mutans polysaccharide deacetylase PgdA, Bacillus subtilis YheN, and similar proteins; Region: CE4_SmPgdA_like; cd10944 991791000701 NodB motif; other site 991791000702 active site 991791000703 catalytic site [active] 991791000704 Zn binding site [ion binding]; other site 991791000705 ketol-acid reductoisomerase; Provisional; Region: PRK05479 991791000706 Acetohydroxy acid isomeroreductase, catalytic domain; Region: IlvN; pfam07991 991791000707 Acetohydroxy acid isomeroreductase, catalytic domain; Region: IlvC; pfam01450 991791000708 Predicted membrane protein [Function unknown]; Region: COG2707 991791000709 Transcriptional regulator [Transcription]; Region: LysR; COG0583 991791000710 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 991791000711 C-terminal substrate binding domain of LysR-type transcriptional regulator CysL, which activates the transcription of the cysJI operon encoding sulfite reductase, contains the type 2 periplasmic binding fold; Region: PBP2_CysL_like; cd08420 991791000712 putative dimerization interface [polypeptide binding]; other site 991791000713 Sulfite reductase, beta subunit (hemoprotein) [Inorganic ion transport and metabolism]; Region: CysI; COG0155 991791000714 Nitrite/Sulfite reductase ferredoxin-like half domain; Region: NIR_SIR_ferr; pfam03460 991791000715 Nitrite/Sulfite reductase ferredoxin-like half domain; Region: NIR_SIR_ferr; pfam03460 991791000716 Glutamyl-tRNA reductase [Coenzyme metabolism]; Region: HemA; COG0373 991791000717 NADP-binding domain of glutamyl-tRNA reductase; Region: NAD_bind_Glutamyl_tRNA_reduct; cd05213 991791000718 tRNA; other site 991791000719 putative tRNA binding site [nucleotide binding]; other site 991791000720 putative NADP binding site [chemical binding]; other site 991791000721 Glutamyl-tRNAGlu reductase, dimerisation domain; Region: GlutR_dimer; pfam00745 991791000722 precorrin-2 dehydrogenase; Provisional; Region: PRK05562 991791000723 Putative NAD(P)-binding; Region: NAD_binding_7; pfam13241 991791000724 porphobilinogen deaminase; Reviewed; Region: hemC; PRK00072 991791000725 Hydroxymethylbilane synthase (HMBS), also known as porphobilinogen deaminase (PBGD), is an intermediate enzyme in the biosynthetic pathway of tetrapyrrolic ring systems, such as heme, chlorophylls, and vitamin B12. HMBS catalyzes the conversion of...; Region: HMBS; cl17708 991791000726 domain interfaces; other site 991791000727 active site 991791000728 Uroporphyrin-III C-methyltransferase (S-Adenosyl-L-methionine:uroporphyrinogen III methyltransferase, SUMT); Region: SUMT; cd11642 991791000729 active site 991791000730 SAM binding site [chemical binding]; other site 991791000731 homodimer interface [polypeptide binding]; other site 991791000732 Uroporphyrinogen-III synthase [Coenzyme metabolism]; Region: HemD; COG1587 991791000733 Uroporphyrinogen-III synthase (HemD) catalyzes the asymmetrical cyclization of tetrapyrrole (linear) to uroporphyrinogen-III, the fourth step in the biosynthesis of heme. This ubiquitous enzyme is present in eukaryotes, bacteria and archaea. Mutations in...; Region: HemD; cd06578 991791000734 active site 991791000735 glutamate-1-semialdehyde aminotransferase; Provisional; Region: PRK00062 991791000736 Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610 991791000737 inhibitor-cofactor binding pocket; inhibition site 991791000738 pyridoxal 5'-phosphate binding site [chemical binding]; other site 991791000739 catalytic residue [active] 991791000740 Porphobilinogen synthase (PBGS), which is also called delta-aminolevulinic acid dehydratase (ALAD), catalyzes the condensation of two 5-aminolevulinic acid (ALA) molecules to form the pyrrole porphobilinogen (PBG), which is the second step in the...; Region: ALAD_PBGS; cd00384 991791000741 dimer interface [polypeptide binding]; other site 991791000742 active site 991791000743 Schiff base residues; other site 991791000744 O-acetylhomoserine sulfhydrylase [Amino acid transport and metabolism]; Region: MET17; COG2873 991791000745 CGS_like: Cystathionine gamma-synthase is a PLP dependent enzyme and catalyzes the committed step of methionine biosynthesis. This pathway is unique to microorganisms and plants, rendering the enzyme an attractive target for the development of...; Region: CGS_like; cd00614 991791000746 homodimer interface [polypeptide binding]; other site 991791000747 substrate-cofactor binding pocket; other site 991791000748 pyridoxal 5'-phosphate binding site [chemical binding]; other site 991791000749 catalytic residue [active] 991791000750 Adenosine 5'-phosphosulfate kinase (APSK) catalyzes the phosphorylation of adenosine 5'-phosphosulfate to form 3'-phosphoadenosine 5'-phosphosulfate (PAPS). The end-product PAPS is a biologically "activated" sulfate form...; Region: APSK; cd02027 991791000751 AAA domain; Region: AAA_18; pfam13238 991791000752 ligand-binding site [chemical binding]; other site 991791000753 adenylylsulfate reductase subunit alpha; Validated; Region: PRK06854 991791000754 L-aspartate oxidase; Provisional; Region: PRK06175 991791000755 Fumarate reductase flavoprotein C-term; Region: Succ_DH_flav_C; pfam02910 991791000756 Ferredoxin [Energy production and conversion]; Region: COG1146 991791000757 RPB11 and RPB3 subunits of RNA polymerase; Region: RNAP_RPB11_RPB3; cl11409 991791000758 ABC transporter, substrate-binding protein, aliphatic sulfonates family; Region: SsuA_fam; TIGR01728 991791000759 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 991791000760 substrate binding pocket [chemical binding]; other site 991791000761 membrane-bound complex binding site; other site 991791000762 hinge residues; other site 991791000763 ABC-type nitrate/sulfonate/bicarbonate transport system, ATPase component [Inorganic ion transport and metabolism]; Region: TauB; COG1116 991791000764 ATP-binding cassette domain of the nitrate and sulfonate transporters; Region: ABC_NrtD_SsuB_transporters; cd03293 991791000765 Walker A/P-loop; other site 991791000766 ATP binding site [chemical binding]; other site 991791000767 Q-loop/lid; other site 991791000768 ABC transporter signature motif; other site 991791000769 Walker B; other site 991791000770 D-loop; other site 991791000771 H-loop/switch region; other site 991791000772 ABC-type nitrate/sulfonate/bicarbonate transport system, permease component [Inorganic ion transport and metabolism]; Region: TauC; COG0600 991791000773 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 991791000774 dimer interface [polypeptide binding]; other site 991791000775 conserved gate region; other site 991791000776 putative PBP binding loops; other site 991791000777 ABC-ATPase subunit interface; other site 991791000778 sulfate adenylyltransferase, small subunit; Region: CysD; TIGR02039 991791000779 This domain is found in phosphoadenosine phosphosulphate (PAPS) reductase enzymes or PAPS sulphotransferase. PAPS reductase is part of the adenine nucleotide alpha hydrolases superfamily also including N type ATP PPases and ATP sulphurylases. A highly...; Region: PAPS_reductase; cd01713 991791000780 Active Sites [active] 991791000781 GTPases - Sulfate adenylate transferase subunit 1 [Inorganic ion transport and metabolism]; Region: CysN; COG2895 991791000782 CysN, together with protein CysD, forms the ATP sulfurylase (ATPS) complex; Region: CysN_ATPS; cd04166 991791000783 CysD dimerization site [polypeptide binding]; other site 991791000784 G1 box; other site 991791000785 putative GEF interaction site [polypeptide binding]; other site 991791000786 GTP/Mg2+ binding site [chemical binding]; other site 991791000787 Switch I region; other site 991791000788 G2 box; other site 991791000789 G3 box; other site 991791000790 Switch II region; other site 991791000791 G4 box; other site 991791000792 G5 box; other site 991791000793 CysN_NodQ_II: This subfamily represents the domain II of the large subunit of ATP sulfurylase (ATPS): CysN or the N-terminal portion of NodQ, found mainly in proteobacteria and homologous to the domain II of EF-Tu. Escherichia coli ATPS consists of CysN...; Region: CysN_NodQ_II; cd03695 991791000794 TCysN_NoDQ_II: This subfamily represents the domain II of the large subunit of ATP sulfurylase (ATPS): CysN or the N-terminal portion of NodQ, found mainly in proteobacteria and homologous to the domain II of EF-Tu. Escherichia coli ATPS consists of CysN...; Region: CysN_NoDQ_III; cd04095 991791000795 Nucleoside/nucleotide kinase (NK) is a protein superfamily consisting of multiple families of enzymes that share structural similarity and are functionally related to the catalysis of the reversible phosphate group transfer from nucleoside triphosphates...; Region: NK; cl17190 991791000796 Bacterial extracellular solute-binding proteins, family 3; Region: SBP_bac_3; pfam00497 991791000797 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 991791000798 substrate binding pocket [chemical binding]; other site 991791000799 membrane-bound complex binding site; other site 991791000800 hinge residues; other site 991791000801 ABC-type arginine transport system, permease component [Amino acid transport and metabolism]; Region: ArtQ; COG4215 991791000802 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 991791000803 dimer interface [polypeptide binding]; other site 991791000804 conserved gate region; other site 991791000805 putative PBP binding loops; other site 991791000806 ABC-ATPase subunit interface; other site 991791000807 ABC-type polar amino acid transport system, ATPase component [Amino acid transport and metabolism]; Region: GlnQ; COG1126 991791000808 ATP-binding cassette domain of the histidine and glutamine transporters; Region: ABC_HisP_GlnQ; cd03262 991791000809 Walker A/P-loop; other site 991791000810 ATP binding site [chemical binding]; other site 991791000811 Q-loop/lid; other site 991791000812 ABC transporter signature motif; other site 991791000813 Walker B; other site 991791000814 D-loop; other site 991791000815 H-loop/switch region; other site 991791000816 Transcriptional regulators of sugar metabolism [Transcription / Carbohydrate transport and metabolism]; Region: GlpR; COG1349 991791000817 helix_turn_helix, Deoxyribose operon repressor; Region: HTH_DEOR; smart00420 991791000818 DeoR C terminal sensor domain; Region: DeoRC; pfam00455 991791000819 Predicted membrane-bound metal-dependent hydrolase (DUF457); Region: DUF457; pfam04307 991791000820 Rrf2 family protein; Region: rrf2_super; TIGR00738 991791000821 Transcriptional regulator; Region: Rrf2; pfam02082 991791000822 carbon-monoxide dehydrogenase, catalytic subunit; Region: CO_DH_cata; TIGR01702 991791000823 Carbon monoxide dehydrogenase (CODH) is found in acetogenic and methanogenic organisms and is responsible for the synthesis and breakdown of acetyl-CoA, respectively. CODH has two types of metal clusters, a cubane [Fe4-S4] center (B-cluster) similar to...; Region: CODH; cd01915 991791000824 ACS interaction site; other site 991791000825 CODH interaction site; other site 991791000826 cubane metal cluster (B-cluster) [ion binding]; other site 991791000827 Ni-Fe-S cluster (C-cluster) [ion binding]; other site 991791000828 Response regulator receiver domain; Region: Response_reg; pfam00072 991791000829 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 991791000830 active site 991791000831 phosphorylation site [posttranslational modification] 991791000832 intermolecular recognition site; other site 991791000833 dimerization interface [polypeptide binding]; other site 991791000834 Chemotaxis protein histidine kinase and related kinases [Cell motility and secretion / Signal transduction mechanisms]; Region: CheA; COG0643 991791000835 Histidine Phosphotransfer domain, involved in signalling through a two part component systems in which an autophosphorylating histidine protein kinase serves as a phosphoryl donor to a response regulator protein; the response regulator protein is...; Region: HPT; cd00088 991791000836 putative binding surface; other site 991791000837 active site 991791000838 P2 response regulator binding domain; Region: P2; pfam07194 991791000839 Signal transducing histidine kinase, homodimeric domain; Region: H-kinase_dim; pfam02895 991791000840 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 991791000841 ATP binding site [chemical binding]; other site 991791000842 Mg2+ binding site [ion binding]; other site 991791000843 G-X-G motif; other site 991791000844 CheA regulatory domain; CheA is a histidine protein kinase present in bacteria and archea. Activated by the chemotaxis receptor a histidine phosphoryl group from CheA is passed directly to an aspartate in the response regulator CheY. This signalling...; Region: CheA_reg; cd00731 991791000845 Chemotaxis signal transduction protein [Cell motility and secretion / Signal transduction mechanisms]; Region: CheW; COG0835 991791000846 Four helix bundle sensory module for signal transduction; Region: 4HB_MCP_1; pfam12729 991791000847 Methyl-accepting chemotaxis protein [Cell motility and secretion / Signal transduction mechanisms]; Region: Tar; COG0840 991791000848 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 991791000849 dimerization interface [polypeptide binding]; other site 991791000850 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 991791000851 dimer interface [polypeptide binding]; other site 991791000852 putative CheW interface [polypeptide binding]; other site 991791000853 Methylase of chemotaxis methyl-accepting proteins [Cell motility and secretion / Signal transduction mechanisms]; Region: CheR; COG1352 991791000854 CheR methyltransferase, SAM binding domain; Region: CheR; pfam01739 991791000855 FOG: CheY-like receiver [Signal transduction mechanisms]; Region: CheY; COG0784 991791000856 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 991791000857 active site 991791000858 phosphorylation site [posttranslational modification] 991791000859 intermolecular recognition site; other site 991791000860 dimerization interface [polypeptide binding]; other site 991791000861 Nucleoside deaminases include adenosine, guanine and cytosine deaminases. These enzymes are Zn dependent and catalyze the deamination of nucleosides. The zinc ion in the active site plays a central role in the proposed catalytic mechanism, activating a...; Region: nucleoside_deaminase; cd01285 991791000862 nucleoside/Zn binding site; other site 991791000863 dimer interface [polypeptide binding]; other site 991791000864 catalytic motif [active] 991791000865 DNA polymerase III subunits gamma and tau; Validated; Region: PRK05563 991791000866 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 991791000867 Walker B motif; other site 991791000868 arginine finger; other site 991791000869 DNA polymerase III subunits gamma and tau domain III; Region: DNA_pol3_gamma3; pfam12169 991791000870 hypothetical protein; Validated; Region: PRK00153 991791000871 recombination protein RecR; Reviewed; Region: recR; PRK00076 991791000872 RecR protein; Region: RecR; pfam02132 991791000873 TOPRIM_recR: topoisomerase-primase (TOPRIM) nucleotidyl transferase/hydrolase domain of the type found in Escherichia coli RecR. RecR participates in the RecFOR pathway of homologous recombinational repair in prokaryotes. This pathway provides a...; Region: TOPRIM_recR; cd01025 991791000874 putative active site [active] 991791000875 putative metal-binding site [ion binding]; other site 991791000876 tetramer interface [polypeptide binding]; other site 991791000877 Protein of unknown function (DUF2508); Region: DUF2508; pfam10704 991791000878 SigmaK-factor processing regulatory protein BofA; Region: BofA; pfam07441 991791000879 putative sporulation protein YtaF; Region: spore_YtaF; TIGR02840 991791000880 Domain of unknown function DUF; Region: DUF204; pfam02659 991791000881 ABC-type multidrug transport system, ATPase component [Defense mechanisms]; Region: CcmA; COG1131 991791000882 ATP-binding cassette domain of the bacitracin-resistance transporter; Region: ABC_BcrA_bacitracin_resist; cd03268 991791000883 Walker A/P-loop; other site 991791000884 ATP binding site [chemical binding]; other site 991791000885 Q-loop/lid; other site 991791000886 ABC transporter signature motif; other site 991791000887 Walker B; other site 991791000888 D-loop; other site 991791000889 H-loop/switch region; other site 991791000890 ABC-type transport system involved in multi-copper enzyme maturation, permease component [General function prediction only]; Region: NosY; COG1277 991791000891 ABC-2 family transporter protein; Region: ABC2_membrane_4; pfam12730 991791000892 ABC-type transport system involved in multi-copper enzyme maturation, permease component [General function prediction only]; Region: NosY; COG1277 991791000893 ABC-2 family transporter protein; Region: ABC2_membrane_3; pfam12698 991791000894 HlyD family secretion protein; Region: HlyD_3; pfam13437 991791000895 DNA-binding protein, stimulates sugar fermentation [General function prediction only]; Region: SfsA; COG1489 991791000896 NTP pyrophosphohydrolases containing a Zn-finger, probably nucleic-acid-binding [DNA replication, recombination, and repair]; Region: NPY1; COG2816 991791000897 NADH pyrophosphatase, a member of the Nudix hydrolase superfamily, catalyzes the cleavage of NADH into reduced nicotinamide mononucleotide (NMNH) and AMP. Like other members of the Nudix family, it requires a divalent cation, such as Mg2+ or Mn2+, for...; Region: NADH_pyrophosphatase; cd03429 991791000898 putative NADH binding site [chemical binding]; other site 991791000899 putative active site [active] 991791000900 nudix motif; other site 991791000901 putative metal binding site [ion binding]; other site 991791000902 ABC-2 family transporter protein; Region: ABC2_membrane_2; cl17866 991791000903 Flagellar biosynthesis chaperone [Cell motility and secretion / Intracellular trafficking and secretion / Posttranslational modification, protein turnover, chaperones]; Region: FliJ; COG2882 991791000904 ABC-2 family transporter protein; Region: ABC2_membrane_2; pfam12679 991791000905 ABC-type multidrug transport system, ATPase component [Defense mechanisms]; Region: CcmA; COG1131 991791000906 ATP-binding cassette domain of the drug resistance transporter and related proteins, subfamily A; Region: ABC_DR_subfamily_A; cd03230 991791000907 Walker A/P-loop; other site 991791000908 ATP binding site [chemical binding]; other site 991791000909 Q-loop/lid; other site 991791000910 ABC transporter signature motif; other site 991791000911 Walker B; other site 991791000912 D-loop; other site 991791000913 H-loop/switch region; other site 991791000914 Class I aldolases; Region: Aldolase_Class_I; cl17187 991791000915 Class I aldolases; Region: Aldolase_Class_I; cl17187 991791000916 Protein of unknown function (DUF4230); Region: DUF4230; pfam14014 991791000917 Methyltransferase domain; Region: Methyltransf_31; pfam13847 991791000918 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 991791000919 S-adenosylmethionine binding site [chemical binding]; other site 991791000920 Acetyltransferases, including N-acetylases of ribosomal proteins [Translation, ribosomal structure and biogenesis]; Region: RimL; COG1670 991791000921 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl17182 991791000922 Predicted phosphatase/phosphohexomutase [General function prediction only]; Region: COG0637 991791000923 haloacid dehalogenase-like hydrolase; Region: HAD; cl17202 991791000924 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 991791000925 motif II; other site 991791000926 Phosphotransferase system, mannitol-specific IIBC component [Carbohydrate transport and metabolism]; Region: MtlA; COG2213 991791000927 PTS system, mannitol-specific IIC component; Region: mtlA; TIGR00851 991791000928 PTS_IIB_mannitol: subunit IIB of enzyme II (EII) of the mannitol-specific phosphoenolpyruvate:carbohydrate phosphotransferase system (PTS). In this system, EII is a mannitol-specific permease with two cytoplasmic domains (IIA and IIB) and a transmembrane...; Region: PTS_IIB_mannitol; cd05567 991791000929 active site 991791000930 P-loop; other site 991791000931 phosphorylation site [posttranslational modification] 991791000932 Transcriptional antiterminator [Transcription]; Region: BglG; COG3711 991791000933 PRD domain; Region: PRD; pfam00874 991791000934 PRD domain; Region: PRD; pfam00874 991791000935 PTS_IIB_bgl_like: the PTS (phosphotransferase system) IIB domain of a family of sensory systems composed of a membrane-bound sugar-sensor (similar to BglF) and a transcription antiterminator (similar to BglG) which regulate expression of genes involved...; Region: PTS_IIB_bgl_like; cd05568 991791000936 active site 991791000937 P-loop; other site 991791000938 phosphorylation site [posttranslational modification] 991791000939 PTS_IIA, PTS system, fructose/mannitol specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_fru; cl00163 991791000940 active site 991791000941 phosphorylation site [posttranslational modification] 991791000942 PTS_IIA, PTS system, fructose/mannitol specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_fru; cd00211 991791000943 active site 991791000944 phosphorylation site [posttranslational modification] 991791000945 mannitol-1-phosphate 5-dehydrogenase; Provisional; Region: PRK02318 991791000946 Mannitol dehydrogenase Rossmann domain; Region: Mannitol_dh; pfam01232 991791000947 Mannitol dehydrogenase C-terminal domain; Region: Mannitol_dh_C; pfam08125 991791000948 glucosamine--fructose-6-phosphate aminotransferase; Reviewed; Region: PRK00331 991791000949 Glutamine amidotransferases class-II (Gn-AT)_GFAT-type. This domain is found at the N-terminus of glucosamine-6P synthase (GlmS, or GFAT in humans). The glutaminase domain catalyzes amide nitrogen transfer from glutamine to the appropriate substrate. In...; Region: GFAT; cd00714 991791000950 glutaminase active site [active] 991791000951 SIS (Sugar ISomerase) domain repeat 1 found in Glucosamine 6-phosphate synthase (GlmS) and Glucosamine-6-phosphate deaminase (GlmD). The SIS domain is found in many phosphosugar isomerases and phosphosugar binding proteins. GlmS contains a N-terminal...; Region: SIS_GlmS_GlmD_1; cd05008 991791000952 dimer interface [polypeptide binding]; other site 991791000953 active site 991791000954 SIS (Sugar ISomerase) domain repeat 2 found in Glucosamine 6-phosphate synthase (GlmS) and Glucosamine-6-phosphate deaminase (GlmD). The SIS domain is found in many phosphosugar isomerases and phosphosugar binding proteins. GlmS contains a N-terminal...; Region: SIS_GlmS_GlmD_2; cd05009 991791000955 dimer interface [polypeptide binding]; other site 991791000956 active site 991791000957 TIGR04076 family protein; Region: TIGR04076 991791000958 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 991791000959 Coenzyme A binding pocket [chemical binding]; other site 991791000960 Cyanate permease [Inorganic ion transport and metabolism]; Region: CynX; COG2807 991791000961 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 991791000962 Transcriptional regulators [Transcription]; Region: MarR; COG1846 991791000963 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 991791000964 putative Zn2+ binding site [ion binding]; other site 991791000965 putative DNA binding site [nucleotide binding]; other site 991791000966 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 991791000967 Coenzyme A binding pocket [chemical binding]; other site 991791000968 ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136 991791000969 ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255 991791000970 Walker A/P-loop; other site 991791000971 ATP binding site [chemical binding]; other site 991791000972 Q-loop/lid; other site 991791000973 ABC transporter signature motif; other site 991791000974 Walker B; other site 991791000975 D-loop; other site 991791000976 H-loop/switch region; other site 991791000977 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG1978 991791000978 Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067 991791000979 catalytic core [active] 991791000980 Ribonuclease BN family enzyme [Replication, recombination, and repair]; Region: Rbn; COG1295 991791000981 ABC-type multidrug transport system, ATPase component [Defense mechanisms]; Region: CcmA; COG1131 991791000982 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 991791000983 Walker A/P-loop; other site 991791000984 ATP binding site [chemical binding]; other site 991791000985 Q-loop/lid; other site 991791000986 ABC transporter signature motif; other site 991791000987 Walker B; other site 991791000988 D-loop; other site 991791000989 H-loop/switch region; other site 991791000990 ABC-2 family transporter protein; Region: ABC2_membrane_3; pfam12698 991791000991 ABC-2 type transporter; Region: ABC2_membrane; pfam01061 991791000992 ABC-2 type transporter; Region: ABC2_membrane; cl17235 991791000993 ABC-type multidrug transport system, permease component [Defense mechanisms]; Region: COG0842 991791000994 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: COG4585 991791000995 Histidine kinase; Region: HisKA_3; pfam07730 991791000996 Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase; Region: HATPase_c; pfam02518 991791000997 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 991791000998 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 991791000999 active site 991791001000 phosphorylation site [posttranslational modification] 991791001001 intermolecular recognition site; other site 991791001002 dimerization interface [polypeptide binding]; other site 991791001003 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 991791001004 DNA binding residues [nucleotide binding] 991791001005 dimerization interface [polypeptide binding]; other site 991791001006 N-acetylmuramic acid-6-phosphate etherase; Reviewed; Region: murQ; PRK05441 991791001007 N-acetylmuramic acid 6-phosphate etherase. Members of this family contain the SIS (Sugar ISomerase) domain. The SIS domain is found in many phosphosugar isomerases and phosphosugar binding proteins. The bacterial cell wall sugar N-acetylmuramic acid...; Region: SIS_Etherase; cd05007 991791001008 putative active site [active] 991791001009 ABC-type dipeptide transport system, periplasmic component [Amino acid transport and metabolism]; Region: DdpA; COG0747 991791001010 The substrate-binding domain of an ABC-type nickel/oligopeptide-like import system contains the type 2 periplasmic binding fold; Region: PBP2_NikA_DppA_OppA_like; cd00995 991791001011 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppB; COG0601 991791001012 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 991791001013 dimer interface [polypeptide binding]; other site 991791001014 conserved gate region; other site 991791001015 putative PBP binding loops; other site 991791001016 ABC-ATPase subunit interface; other site 991791001017 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppC; COG1173 991791001018 N-terminal TM domain of oligopeptide transport permease C; Region: OppC_N; pfam12911 991791001019 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 991791001020 dimer interface [polypeptide binding]; other site 991791001021 conserved gate region; other site 991791001022 putative PBP binding loops; other site 991791001023 ABC-ATPase subunit interface; other site 991791001024 ABC-type dipeptide/oligopeptide/nickel transport system, ATPase component [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppD; COG0444 991791001025 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 991791001026 Walker A/P-loop; other site 991791001027 ATP binding site [chemical binding]; other site 991791001028 Q-loop/lid; other site 991791001029 ABC transporter signature motif; other site 991791001030 Walker B; other site 991791001031 D-loop; other site 991791001032 H-loop/switch region; other site 991791001033 oligopeptide/dipeptide ABC transporter, ATP-binding protein, C-terminal domain; Region: oligo_HPY; TIGR01727 991791001034 dipeptide transporter ATP-binding subunit; Provisional; Region: dppF; PRK11308 991791001035 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 991791001036 Walker A/P-loop; other site 991791001037 ATP binding site [chemical binding]; other site 991791001038 Q-loop/lid; other site 991791001039 ABC transporter signature motif; other site 991791001040 Walker B; other site 991791001041 D-loop; other site 991791001042 H-loop/switch region; other site 991791001043 oligopeptide/dipeptide ABC transporter, ATP-binding protein, C-terminal domain; Region: oligo_HPY; TIGR01727 991791001044 Beta-lactamase class C and other penicillin binding proteins [Defense mechanisms]; Region: AmpC; COG1680 991791001045 Beta-lactamase; Region: Beta-lactamase; pfam00144 991791001046 Beta-glucosidase-related glycosidases [Carbohydrate transport and metabolism]; Region: BglX; COG1472 991791001047 Glycosyl hydrolase family 3 N terminal domain; Region: Glyco_hydro_3; pfam00933 991791001048 Glycosyl hydrolase family 3 C-terminal domain; Region: Glyco_hydro_3_C; pfam01915 991791001049 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cd00012 991791001050 nucleotide binding site [chemical binding]; other site 991791001051 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 991791001052 Coenzyme A binding pocket [chemical binding]; other site 991791001053 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 991791001054 Coenzyme A binding pocket [chemical binding]; other site 991791001055 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3876 991791001056 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 991791001057 non-specific DNA binding site [nucleotide binding]; other site 991791001058 salt bridge; other site 991791001059 sequence-specific DNA binding site [nucleotide binding]; other site 991791001060 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 991791001061 binding surface 991791001062 TPR motif; other site 991791001063 Tetratricopeptide repeat; Region: TPR_12; pfam13424 991791001064 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 991791001065 binding surface 991791001066 Tetratricopeptide repeat; Region: TPR_12; pfam13424 991791001067 TPR motif; other site 991791001068 Tetratricopeptide repeat; Region: TPR_12; pfam13424 991791001069 6-phosphogluconolactonase/Glucosamine-6-phosphate isomerase/deaminase [Carbohydrate transport and metabolism]; Region: NagB; COG0363 991791001070 GlcN6P_deaminase: Glucosamine-6-phosphate (GlcN6P) deaminase subfamily; GlcN6P deaminase catalyzes the reversible conversion of GlcN6P to D-fructose-6-phosphate (Fru6P) and ammonium. The reaction is an aldo-keto isomerization coupled with an amination or...; Region: GlcN6P_deaminase; cd01399 991791001071 active site 991791001072 trimer interface [polypeptide binding]; other site 991791001073 allosteric site; other site 991791001074 active site lid [active] 991791001075 hexamer (dimer of trimers) interface [polypeptide binding]; other site 991791001076 N-acetylglucosamine-6-phosphate deacetylase [Carbohydrate transport and metabolism]; Region: NagA; COG1820 991791001077 N-acetylglucosamine-6-phosphate deacetylase, NagA, catalyzes the hydrolysis of the N-acetyl group of N-acetyl-glucosamine-6-phosphate (GlcNAc-6-P) to glucosamine 6-phosphate and acetate. This is the first committed step in the biosynthetic pathway to...; Region: NagA; cd00854 991791001078 active site 991791001079 dimer interface [polypeptide binding]; other site 991791001080 Transcriptional regulators [Transcription]; Region: PhnF; COG2188 991791001081 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 991791001082 DNA-binding site [nucleotide binding]; DNA binding site 991791001083 UTRA domain; Region: UTRA; pfam07702 991791001084 Beta-lactamase class A [Defense mechanisms]; Region: PenP; COG2367 991791001085 Beta-lactamase enzyme family; Region: Beta-lactamase2; pfam13354 991791001086 Transcriptional regulators [Transcription]; Region: RpiR; COG1737 991791001087 Helix-turn-helix domain, rpiR family; Region: HTH_6; pfam01418 991791001088 RpiR-like protein. RpiR contains a SIS (Sugar ISomerase) domain, which is found in many phosphosugar isomerases and phosphosugar binding proteins. In E. coli, rpiR negatively regulates the expression of rpiB gene. Both rpiB and rpiA are ribose phosphate...; Region: SIS_RpiR; cd05013 991791001089 putative active site [active] 991791001090 L-alanine-DL-glutamate epimerase and related enzymes of enolase superfamily [Cell envelope biogenesis, outer membrane / General function prediction only]; Region: COG4948 991791001091 L-Ala-D/L-Glu epimerase catalyzes the epimerization of L-Ala-D/L-Glu and other dipeptides. The genomic context and the substrate specificity of characterized members of this family from E.coli and B.subtilis indicates a possible role in the metabolism of...; Region: L-Ala-DL-Glu_epimerase; cd03319 991791001092 active site 991791001093 4-amino-4-deoxy-L-arabinose transferase and related glycosyltransferases of PMT family [Cell envelope biogenesis, outer membrane]; Region: ArnT; COG1807 991791001094 Dolichyl-phosphate-mannose-protein mannosyltransferase; Region: PMT_2; pfam13231 991791001095 undecaprenyl phosphate 4-deoxy-4-formamido-L-arabinose transferase; Provisional; Region: PRK10714 991791001096 Bacterial DPM1_like enzymes are related to eukaryotic DPM1; Region: DPM1_like_bac; cd04187 991791001097 Ligand binding site; other site 991791001098 Putative Catalytic site; other site 991791001099 DXD motif; other site 991791001100 Predicted transcriptional regulators [Transcription]; Region: COG1733 991791001101 HxlR-like helix-turn-helix; Region: HxlR; pfam01638 991791001102 NADH:flavin oxidoreductases, Old Yellow Enzyme family [Energy production and conversion]; Region: NemA; COG1902 991791001103 Old yellow enzyme (OYE)-like FMN binding domain. OYE was the first flavin-dependent enzyme identified, however its true physiological role remains elusive to this day. Each monomer of OYE contains FMN as a non-covalently bound cofactor, uses NADPH as a...; Region: OYE_like_FMN_family; cd02803 991791001104 active site 991791001105 FMN binding site [chemical binding]; other site 991791001106 substrate binding site [chemical binding]; other site 991791001107 putative catalytic residue [active] 991791001108 helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347 991791001109 MarR family; Region: MarR; pfam01047 991791001110 Predicted membrane protein [Function unknown]; Region: COG2364 991791001111 Uncharacterized BCR, YitT family COG1284; Region: DUF161; pfam02588 991791001112 Predicted membrane protein [Function unknown]; Region: COG2717 991791001113 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 991791001114 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 991791001115 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 991791001116 Asp/Glu/Hydantoin racemase; Region: Asp_Glu_race; pfam01177 991791001117 flavodoxin; Provisional; Region: PRK06242 991791001118 Sortase D (SrtD) is a membrane transpeptidase found in gram-positive bacteria that anchors surface proteins to peptidoglycans of the bacterial cell wall envelope. This involves a transpeptidation reaction in which the surface protein substrate is cleaved...; Region: Sortase_D_5; cd06166 991791001119 active site 991791001120 catalytic site [active] 991791001121 metallophosphatase superfamily, metallophosphatase domain; Region: MPP_superfamily; cl13995 991791001122 Calcineurin-like phosphoesterase; Region: Metallophos; pfam00149 991791001123 active site 991791001124 metal binding site [ion binding]; metal-binding site 991791001125 LPXTG-motif cell wall anchor domain; Region: LPXTG_anchor; TIGR01167 991791001126 Predicted multitransmembrane protein [Function unknown]; Region: COG5438 991791001127 biotin synthase; Region: bioB; TIGR00433 991791001128 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 991791001129 FeS/SAM binding site; other site 991791001130 Biotin and Thiamin Synthesis associated domain; Region: BATS; pfam06968 991791001131 Uncharacterized conserved protein [General function prediction only]; Region: BioY; COG1268 991791001132 Biotin operon repressor [Transcription]; Region: BirA; COG1654 991791001133 Biotin-(acetyl-CoA carboxylase) ligase [Coenzyme metabolism]; Region: BirA; COG0340 991791001134 Biotin/lipoate A/B protein ligase family; Region: BPL_LplA_LipB; pfam03099 991791001135 Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cl00107 991791001136 Cellulase M and related proteins [Carbohydrate transport and metabolism]; Region: FrvX; COG1363 991791001137 M42 Peptidase, Endoglucanases; Region: M42_Frv; cd05656 991791001138 oligomer interface [polypeptide binding]; other site 991791001139 active site 991791001140 metal binding site [ion binding]; metal-binding site 991791001141 Cellulase M and related proteins [Carbohydrate transport and metabolism]; Region: FrvX; COG1363 991791001142 M42 Peptidase, Endoglucanases; Region: M42_Frv; cd05656 991791001143 oligomer interface [polypeptide binding]; other site 991791001144 active site 991791001145 metal binding site [ion binding]; metal-binding site 991791001146 Cellulase M and related proteins [Carbohydrate transport and metabolism]; Region: FrvX; COG1363 991791001147 Zinc peptidases M18, M20, M28, and M42; Region: Zinc_peptidase_like; cl14876 991791001148 metal binding site [ion binding]; metal-binding site 991791001149 Prephenate dehydratase [Amino acid transport and metabolism]; Region: PheA; COG0077 991791001150 Prephenate dehydratase; Region: PDT; pfam00800 991791001151 C-terminal ACT domain of the bifunctional chorismate mutase-prephenate dehydratase (CM-PDT) enzyme and the prephenate dehydratase (PDT) enzyme; Region: ACT_CM-PDT; cd04905 991791001152 putative L-Phe binding site [chemical binding]; other site 991791001153 Integral membrane protein TerC family; Region: TerC; cl10468 991791001154 Family 4 Uracil-DNA glycosylase (UDG), found exclusively in thermophilic organisms; Region: UDG_F4_TTUDGA_like; cd10030 991791001155 active site 991791001156 Fe-S cluster binding site [ion binding]; other site 991791001157 Clostripain family; Region: Peptidase_C11; pfam03415 991791001158 Serine-pyruvate aminotransferase/archaeal aspartate aminotransferase [Amino acid transport and metabolism]; Region: COG0075 991791001159 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 991791001160 catalytic residue [active] 991791001161 Human Ape1-like subfamily of the ExoIII family purinic/apyrimidinic (AP) endonucleases; Region: Ape1-like_AP-endo; cd09087 991791001162 active site 991791001163 putative catalytic site [active] 991791001164 DNA binding site [nucleotide binding] 991791001165 putative phosphate binding site [ion binding]; other site 991791001166 metal binding site A [ion binding]; metal-binding site 991791001167 AP binding site [nucleotide binding]; other site 991791001168 metal binding site B [ion binding]; metal-binding site 991791001169 Predicted N6-adenine-specific DNA methylase [DNA replication, recombination, and repair]; Region: COG0116 991791001170 THUMP domain associated with S-adenosylmethionine-dependent methyltransferases; Region: THUMP_AdoMetMT; cd11715 991791001171 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl17173 991791001172 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 991791001173 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 991791001174 active site 991791001175 phosphorylation site [posttranslational modification] 991791001176 intermolecular recognition site; other site 991791001177 dimerization interface [polypeptide binding]; other site 991791001178 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 991791001179 DNA binding site [nucleotide binding] 991791001180 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 991791001181 His Kinase A (phosphoacceptor) domain; Region: HisKA; smart00388 991791001182 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 991791001183 ATP binding site [chemical binding]; other site 991791001184 Mg2+ binding site [ion binding]; other site 991791001185 G-X-G motif; other site 991791001186 ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136 991791001187 ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255 991791001188 Walker A/P-loop; other site 991791001189 ATP binding site [chemical binding]; other site 991791001190 Q-loop/lid; other site 991791001191 ABC transporter signature motif; other site 991791001192 Walker B; other site 991791001193 D-loop; other site 991791001194 H-loop/switch region; other site 991791001195 ABC-type antimicrobial peptide transport system, permease component [Defense mechanisms]; Region: SalY; COG0577 991791001196 FtsX-like permease family; Region: FtsX; pfam02687 991791001197 Predicted Zn-dependent proteases and their inactivated homologs [General function prediction only]; Region: TldD; COG0312 991791001198 Predicted Zn-dependent proteases and their inactivated homologs [General function prediction only]; Region: TldD; COG0312 991791001199 Transcriptional regulators of sugar metabolism [Transcription / Carbohydrate transport and metabolism]; Region: GlpR; COG1349 991791001200 helix_turn_helix, Deoxyribose operon repressor; Region: HTH_DEOR; smart00420 991791001201 DeoR C terminal sensor domain; Region: DeoRC; pfam00455 991791001202 Fructose-1-phosphate kinase and related fructose-6-phosphate kinase (PfkB) [Carbohydrate transport and metabolism]; Region: FruK; COG1105 991791001203 1-phosphofructokinase (FruK), minor 6-phosphofructokinase (pfkB) and related sugar kinases. FruK plays an important role in the predominant pathway for fructose utilisation.This group also contains tagatose-6-phophate kinase, an enzyme of the tagatose...; Region: FruK_PfkB_like; cd01164 991791001204 putative substrate binding site [chemical binding]; other site 991791001205 putative ATP binding site [chemical binding]; other site 991791001206 PTS_IIA, PTS system, fructose/mannitol specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_fru; cd00211 991791001207 active site 991791001208 phosphorylation site [posttranslational modification] 991791001209 PTS_IIB_fructose: subunit IIB of enzyme II (EII) of the fructose-specific phosphoenolpyruvate:carbohydrate phosphotransferase system (PTS). In this system, EII (also referred to as FruAB) is a fructose-specific permease made up of two proteins (FruA and...; Region: PTS_IIB_fructose; cd05569 991791001210 active site 991791001211 P-loop; other site 991791001212 phosphorylation site [posttranslational modification] 991791001213 Phosphotransferase system, fructose-specific IIC component [Carbohydrate transport and metabolism]; Region: FruA; COG1299 991791001214 Chloramphenicol O-acetyltransferase [Defense mechanisms]; Region: COG4845 991791001215 Chloramphenicol acetyltransferase; Region: CAT; smart01059 991791001216 ABC-type multidrug transport system, ATPase component [Defense mechanisms]; Region: CcmA; COG1131 991791001217 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 991791001218 Walker A/P-loop; other site 991791001219 ATP binding site [chemical binding]; other site 991791001220 Q-loop/lid; other site 991791001221 ABC transporter signature motif; other site 991791001222 Walker B; other site 991791001223 D-loop; other site 991791001224 H-loop/switch region; other site 991791001225 ABC-type multidrug transport system, permease component [Defense mechanisms]; Region: COG0842 991791001226 ABC-2 type transporter; Region: ABC2_membrane; pfam01061 991791001227 ABC-type multidrug transport system, permease component [Defense mechanisms]; Region: COG0842 991791001228 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: COG4585 991791001229 Histidine kinase; Region: HisKA_3; pfam07730 991791001230 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 991791001231 ATP binding site [chemical binding]; other site 991791001232 Mg2+ binding site [ion binding]; other site 991791001233 G-X-G motif; other site 991791001234 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 991791001235 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 991791001236 active site 991791001237 phosphorylation site [posttranslational modification] 991791001238 intermolecular recognition site; other site 991791001239 dimerization interface [polypeptide binding]; other site 991791001240 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 991791001241 DNA binding residues [nucleotide binding] 991791001242 dimerization interface [polypeptide binding]; other site 991791001243 ABC-type multidrug transport system, ATPase component [Defense mechanisms]; Region: CcmA; COG1131 991791001244 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 991791001245 Walker A/P-loop; other site 991791001246 ATP binding site [chemical binding]; other site 991791001247 Q-loop/lid; other site 991791001248 ABC transporter signature motif; other site 991791001249 Walker B; other site 991791001250 D-loop; other site 991791001251 H-loop/switch region; other site 991791001252 ABC-2 family transporter protein; Region: ABC2_membrane_3; pfam12698 991791001253 ABC-2 type transporter; Region: ABC2_membrane; cl17235 991791001254 ABC-type multidrug transport system, permease component [Defense mechanisms]; Region: COG0842 991791001255 ABC-2 type transporter; Region: ABC2_membrane; pfam01061 991791001256 ABC-type transport system, involved in lipoprotein release, permease component [Cell envelope biogenesis, outer membrane]; Region: LolE; COG4591 991791001257 MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704 991791001258 FtsX-like permease family; Region: FtsX; pfam02687 991791001259 ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136 991791001260 ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255 991791001261 Walker A/P-loop; other site 991791001262 ATP binding site [chemical binding]; other site 991791001263 Q-loop/lid; other site 991791001264 ABC transporter signature motif; other site 991791001265 Walker B; other site 991791001266 D-loop; other site 991791001267 H-loop/switch region; other site 991791001268 Sulfite exporter TauE/SafE; Region: TauE; pfam01925 991791001269 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3328 991791001270 This conserved domain belongs to a superfamily including the bleomycin resistance protein, glyoxalase I, and type I ring-cleaving dioxygenases; Region: Glo_EDI_BRP_like_1; cd08352 991791001271 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 991791001272 putative metal binding site [ion binding]; other site 991791001273 Cache domain; Region: Cache_1; pfam02743 991791001274 Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer); Region: MA; smart00283 991791001275 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 991791001276 dimer interface [polypeptide binding]; other site 991791001277 putative CheW interface [polypeptide binding]; other site 991791001278 Uncharacterized Fe-S protein [Energy production and conversion]; Region: COG1600 991791001279 Helix-turn-helix domain; Region: HTH_17; pfam12728 991791001280 Periplasmic molybdate-binding protein/domain [Inorganic ion transport and metabolism]; Region: COG1910 991791001281 nitrogenase reductase; Reviewed; Region: nifH; PRK13235 991791001282 NifH gene encodes component II (iron protein) of nitrogenase. Nitrogenase is responsible for the biological nitrogen fixation, i.e. reduction of molecular nitrogen to ammonia. NifH consists of two oxygen-sensitive metallosulfur proteins: the...; Region: NifH; cd02040 991791001283 Nucleotide-binding sites [chemical binding]; other site 991791001284 Walker A motif; other site 991791001285 Switch I region of nucleotide binding site; other site 991791001286 Fe4S4 binding sites [ion binding]; other site 991791001287 Switch II region of nucleotide binding site; other site 991791001288 Nitrogen regulatory protein P-II; Region: P-II; pfam00543 991791001289 Nitrogen regulatory protein P-II; Region: P-II; smart00938 991791001290 Nitrogen regulatory protein PII [Amino acid transport and metabolism]; Region: GlnK; COG0347 991791001291 Nitrogen regulatory protein P-II; Region: P-II; smart00938 991791001292 The nitrogenase enzyme system catalyzes the ATP-dependent reduction of dinitrogen to ammonia. This group contains both alpha and beta subunits of component 1 of the three known genetically distinct types of nitrogenase systems: a molybdenum-dependent; Region: Oxidoreductase_nitrogenase; cl02775 991791001293 Nitrogenase molybdenum-iron protein, alpha and beta chains [Energy production and conversion]; Region: NifD; COG2710 991791001294 The nitrogenase enzyme system catalyzes the ATP-dependent reduction of dinitrogen to ammonia. This group contains both alpha and beta subunits of component 1 of the three known genetically distinct types of nitrogenase systems: a molybdenum-dependent; Region: Oxidoreductase_nitrogenase; cl02775 991791001295 Nitrogenase component 1 type Oxidoreductase; Region: Oxidored_nitro; pfam00148 991791001296 nitrogenase molybdenum-cofactor biosynthesis protein NifE; Provisional; Region: PRK14478 991791001297 nitrogenase molybdenum-iron cofactor biosynthesis protein NifE; Region: nifE; TIGR01283 991791001298 The nitrogenase enzyme system catalyzes the ATP-dependent reduction of dinitrogen to ammonia. This group contains both alpha and beta subunits of component 1 of the three known genetically distinct types of nitrogenase systems: a molybdenum-dependent; Region: Oxidoreductase_nitrogenase; cl02775 991791001299 Nitrogenase component 1 type Oxidoreductase; Region: Oxidored_nitro; pfam00148 991791001300 nitrogenase cofactor biosynthesis protein NifB; Region: nifB; TIGR01290 991791001301 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 991791001302 FeS/SAM binding site; other site 991791001303 NifB belongs to a family of iron-molybdenum cluster-binding proteins that includes NifX, and NifY, all of which are involved in the synthesis of an iron-molybdenum cofactor (FeMo-co) that binds the active site of the dinitrogenase enzyme as part of...; Region: NifB; cd00852 991791001304 Isopropylmalate/homocitrate/citramalate synthases [Amino acid transport and metabolism]; Region: LeuA; COG0119 991791001305 DRE-TIM metallolyase superfamily; Region: DRE_TIM_metallolyase; cl07974 991791001306 metal binding site [ion binding]; metal-binding site 991791001307 Streptomyces rubellomurinus FrbC and related proteins, catalytic TIM barrel domain; Region: DRE_TIM_NifV; cd07939 991791001308 active site 991791001309 catalytic residues [active] 991791001310 metal binding site [ion binding]; metal-binding site 991791001311 Tryptophan-rich sensory protein (mitochondrial benzodiazepine receptor homolog) [Signal transduction mechanisms]; Region: COG3476 991791001312 Phosphoserine phosphatase [Amino acid transport and metabolism]; Region: SerB; COG0560 991791001313 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 991791001314 motif II; other site 991791001315 ABC-2 family transporter protein; Region: ABC2_membrane_4; pfam12730 991791001316 Predicted transcriptional regulators [Transcription]; Region: COG1725 991791001317 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 991791001318 DNA-binding site [nucleotide binding]; DNA binding site 991791001319 gallidermin-class lantibiotic protection ABC transporter, ATP-binding subunit; Region: galliderm_ABC; TIGR03740 991791001320 ATP-binding cassette domain of the drug resistance transporter and related proteins, subfamily A; Region: ABC_DR_subfamily_A; cd03230 991791001321 Walker A/P-loop; other site 991791001322 ATP binding site [chemical binding]; other site 991791001323 Q-loop/lid; other site 991791001324 ABC transporter signature motif; other site 991791001325 Walker B; other site 991791001326 D-loop; other site 991791001327 H-loop/switch region; other site 991791001328 L-lactate dehydrogenase; Reviewed; Region: ldh; PRK00066 991791001329 A subgroup of L-lactate dehydrogenases; Region: LDH_2; cd05292 991791001330 NAD binding site [chemical binding]; other site 991791001331 dimer interface [polypeptide binding]; other site 991791001332 substrate binding site [chemical binding]; other site 991791001333 tetramer (dimer of dimers) interface [polypeptide binding]; other site 991791001334 ABC-type Na+ transport system, ATPase component [Energy production and conversion / Inorganic ion transport and metabolism]; Region: NatA; COG4555 991791001335 ATP-binding cassette domain of the drug resistance transporter and related proteins, subfamily A; Region: ABC_DR_subfamily_A; cd03230 991791001336 Walker A/P-loop; other site 991791001337 ATP binding site [chemical binding]; other site 991791001338 Q-loop/lid; other site 991791001339 ABC transporter signature motif; other site 991791001340 Walker B; other site 991791001341 D-loop; other site 991791001342 H-loop/switch region; other site 991791001343 4-hydroxybenzoyl-CoA thioesterase (4HBT). Catalyzes the final step in the 4-chlorobenzoate degradation pathway in which 4-chlorobenzoate is converted to 4-hydroxybenzoate in certain soil-dwelling bacteria. 4HBT forms a homotetramer with four active sites; Region: 4HBT; cd00586 991791001344 active site 991791001345 Amino acid permease; Region: AA_permease_2; pfam13520 991791001346 2-isopropylmalate synthase; Validated; Region: PRK03739 991791001347 Mycobacterium tuberculosis LeuA3 and related proteins, N-terminal catalytic TIM barrel domain; Region: DRE_TIM_LeuA; cd07942 991791001348 active site 991791001349 catalytic residues [active] 991791001350 metal binding site [ion binding]; metal-binding site 991791001351 LeuA allosteric (dimerisation) domain; Region: LeuA_dimer; pfam08502 991791001352 aspartate ammonia-lyase; Provisional; Region: PRK13353 991791001353 Aspartase; Region: Aspartase; cd01357 991791001354 active sites [active] 991791001355 tetramer interface [polypeptide binding]; other site 991791001356 c-di-GMP phosphodiesterase class II (HD-GYP domain) [Signal transduction mechanisms]; Region: COG2206 991791001357 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 991791001358 Zn2+ binding site [ion binding]; other site 991791001359 Mg2+ binding site [ion binding]; other site 991791001360 aspartate kinase; Reviewed; Region: PRK09034 991791001361 AAK_AKiii-YclM-BS: Amino Acid Kinase Superfamily (AAK), AKiii-YclM-BS; this CD includes the N-terminal catalytic aspartokinase (AK) domain of the lysine plus threonine-sensitive aspartokinase isoenzyme AKIII, a monofunctional class enzyme found in...; Region: AAK_AKiii-YclM-BS; cd04245 991791001362 putative catalytic residues [active] 991791001363 putative nucleotide binding site [chemical binding]; other site 991791001364 putative aspartate binding site [chemical binding]; other site 991791001365 ACT domains located C-terminal to the catalytic domain of the lysine plus threonine-sensitive aspartokinase isoenzyme AKIII; Region: ACT_AKiii-YclM-BS_1; cd04911 991791001366 allosteric regulatory residue; other site 991791001367 ACT domains located C-terminal to the catalytic domain of the lysine plus threonine-sensitive aspartokinase isoenzyme AKIII; Region: ACT_AKiii-YclM-BS_2; cd04916 991791001368 nitrogen fixation protein NifM; Region: nifM_nitrog; TIGR02933 991791001369 PPIC-type PPIASE domain; Region: Rotamase; pfam00639 991791001370 ABC-type sulfate transport system, permease component [Posttranslational modification, protein turnover, chaperones]; Region: CysU; COG0555 991791001371 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 991791001372 putative PBP binding loops; other site 991791001373 ABC-ATPase subunit interface; other site 991791001374 ABC-type molybdate transport system, periplasmic component [Inorganic ion transport and metabolism]; Region: ModA; COG0725 991791001375 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; cl17199 991791001376 Guanine deaminase (GDEase). Guanine deaminase is an aminohydrolase responsible for the conversion of guanine to xanthine and ammonia, the first step to utilize guanine as a nitrogen source. This reaction also removes the guanine base from the pool and...; Region: GDEase; cd01303 991791001377 guanine deaminase; Region: guan_deamin; TIGR02967 991791001378 active site 991791001379 MogA_MoaB family. Members of this family are involved in biosynthesis of the molybdenum cofactor (MoCF) an essential cofactor of a diverse group of redox enzymes. MoCF biosynthesis is an evolutionarily conserved pathway present in eubacteria, archaea; Region: MogA_MoaB; cd00886 991791001380 MPT binding site; other site 991791001381 trimer interface [polypeptide binding]; other site 991791001382 NAD-dependent deacetylase; Provisional; Region: PRK00481 991791001383 SIR2 superfamily of proteins includes silent information regulator 2 (Sir2) enzymes which catalyze NAD+-dependent protein/histone deacetylation, where the acetyl group from the lysine epsilon-amino group is transferred to the ADP-ribose moiety of NAD+; Region: SIR2; cl00195 991791001384 Nucleotidyltransferase/DNA polymerase involved in DNA repair [DNA replication, recombination, and repair]; Region: DinP; COG0389 991791001385 DNA Polymerase IV/Kappa; Region: PolY_Pol_IV_kappa; cd03586 991791001386 active site 991791001387 DNA binding site [nucleotide binding] 991791001388 Domain of unknown function (DUF4113); Region: DUF4113; pfam13438 991791001389 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4200 991791001390 ABC-2 family transporter protein; Region: ABC2_membrane_4; pfam12730 991791001391 ATP-binding cassette domain of the bacitracin-resistance transporter; Region: ABC_BcrA_bacitracin_resist; cd03268 991791001392 gallidermin-class lantibiotic protection ABC transporter, ATP-binding subunit; Region: galliderm_ABC; TIGR03740 991791001393 Walker A/P-loop; other site 991791001394 ATP binding site [chemical binding]; other site 991791001395 Q-loop/lid; other site 991791001396 ABC transporter signature motif; other site 991791001397 Walker B; other site 991791001398 D-loop; other site 991791001399 H-loop/switch region; other site 991791001400 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 991791001401 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 991791001402 active site 991791001403 phosphorylation site [posttranslational modification] 991791001404 intermolecular recognition site; other site 991791001405 dimerization interface [polypeptide binding]; other site 991791001406 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 991791001407 DNA binding site [nucleotide binding] 991791001408 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 991791001409 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 991791001410 dimer interface [polypeptide binding]; other site 991791001411 phosphorylation site [posttranslational modification] 991791001412 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 991791001413 ATP binding site [chemical binding]; other site 991791001414 Mg2+ binding site [ion binding]; other site 991791001415 G-X-G motif; other site 991791001416 Methionine synthase I (cobalamin-dependent), methyltransferase domain [Amino acid transport and metabolism]; Region: MetH; COG0646 991791001417 bifunctional homocysteine S-methyltransferase/5,10-methylenetetrahydrofolate reductase protein; Reviewed; Region: PRK08645 991791001418 Methylenetetrahydrofolate reductase (MTHFR). 5,10-Methylenetetrahydrofolate is reduced to 5-methyltetrahydrofolate by methylenetetrahydrofolate reductase, a cytoplasmic, NAD(P)-dependent enzyme. 5-methyltetrahydrofolate is utilized by methionine synthase...; Region: MTHFR; cd00537 991791001419 FAD binding site [chemical binding]; other site 991791001420 Protein of unknown function (DUF3006); Region: DUF3006; pfam11213 991791001421 LD-Carboxypeptidase, a serine protease, includes microcin C7 self immunity protein; Region: Peptidase_S66; cd07025 991791001422 dimer interface [polypeptide binding]; other site 991791001423 catalytic triad [active] 991791001424 Mg2+ and Co2+ transporters [Inorganic ion transport and metabolism]; Region: CorA; COG0598 991791001425 uncharacterized bacterial subfamily of the Escherichia coli CorA-Salmonella typhimurium ZntB family; Region: EcCorA_ZntB-like_u2; cd12827 991791001426 Cl binding site [ion binding]; other site 991791001427 oligomer interface [polypeptide binding]; other site 991791001428 Metal-dependent amidase/aminoacylase/carboxypeptidase [General function prediction only]; Region: AbgB; COG1473 991791001429 Zinc peptidases M18, M20, M28, and M42; Region: Zinc_peptidase_like; cl14876 991791001430 metal binding site [ion binding]; metal-binding site 991791001431 Zinc peptidases M18, M20, M28, and M42; Region: Zinc_peptidase_like; cl14876 991791001432 Inhibitor of sigma-G Gin; Region: Gin; pfam10764 991791001433 Arginine/lysine/ornithine decarboxylases [Amino acid transport and metabolism]; Region: LdcC; COG1982 991791001434 Ornithine decarboxylase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD corresponds to ornithine decarboxylase (ODC), arginine decarboxylase (ADC) and lysine...; Region: Orn_deC_like; cd00615 991791001435 homodimer interface [polypeptide binding]; other site 991791001436 pyridoxal 5'-phosphate binding site [chemical binding]; other site 991791001437 catalytic residue [active] 991791001438 Orn/Lys/Arg decarboxylase, C-terminal domain; Region: OKR_DC_1_C; pfam03711 991791001439 Guanylate kinase [Nucleotide transport and metabolism]; Region: Gmk; COG0194 991791001440 Nucleoside/nucleotide kinase (NK) is a protein superfamily consisting of multiple families of enzymes that share structural similarity and are functionally related to the catalysis of the reversible phosphate group transfer from nucleoside triphosphates...; Region: NK; cl17190 991791001441 active site 991791001442 Protein of unknown function (DUF970); Region: DUF970; pfam06153 991791001443 DNA polymerase III subunit delta'; Validated; Region: PRK05564 991791001444 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 991791001445 Walker A motif; other site 991791001446 ATP binding site [chemical binding]; other site 991791001447 Walker B motif; other site 991791001448 arginine finger; other site 991791001449 Uncharacterized homolog of PSP1 [Function unknown]; Region: COG1774 991791001450 Heavy-metal-associated domain (HMA) is a conserved domain of approximately 30 amino acid residues found in a number of proteins that transport or detoxify heavy metals, for example, the CPx-type heavy metal ATPases and copper chaperones. HMA domain...; Region: HMA; cd00371 991791001451 metal-binding site [ion binding] 991791001452 The HCP family of iron-sulfur proteins includes hybrid cluster protein (HCP), acetyl-CoA synthase (ACS), and carbon monoxide dehydrogenase (CODH), all of which contain [Fe4-S4] metal clusters at their active sites. These proteins have a conserved...; Region: HCP_like; cl14655 991791001453 4Fe-4S dicluster domain; Region: Fer4_7; pfam12838 991791001454 Flagellar motor component [Cell motility and secretion]; Region: MotA; COG1291 991791001455 MotA/TolQ/ExbB proton channel family; Region: MotA_ExbB; cl00568 991791001456 Flagellar motor protein [Cell motility and secretion]; Region: MotB; COG1360 991791001457 Membrane MotB of proton-channel complex MotA/MotB; Region: MotB_plug; pfam13677 991791001458 Peptidoglycan binding domains similar to the C-terminal domain of outer-membrane protein OmpA; Region: OmpA_C-like; cd07185 991791001459 ligand binding site [chemical binding]; other site 991791001460 Predicted O-methyltransferase [General function prediction only]; Region: COG4123 991791001461 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 991791001462 S-adenosylmethionine binding site [chemical binding]; other site 991791001463 Predicted methyltransferases [General function prediction only]; Region: COG0313 991791001464 Ribosomal RNA small subunit methyltransferase I, also known as rRNA (cytidine-2'-O-)-methyltransferase RsmI; Region: RsmI; cd11648 991791001465 putative SAM binding site [chemical binding]; other site 991791001466 putative homodimer interface [polypeptide binding]; other site 991791001467 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3883 991791001468 Cell wall-associated hydrolases (invasion-associated proteins) [Cell envelope biogenesis, outer membrane]; Region: Spr; COG0791 991791001469 NlpC/P60 family; Region: NLPC_P60; pfam00877 991791001470 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3883 991791001471 Cell wall-associated hydrolases (invasion-associated proteins) [Cell envelope biogenesis, outer membrane]; Region: Spr; COG0791 991791001472 NlpC/P60 family; Region: NLPC_P60; pfam00877 991791001473 Regulators of stationary/sporulation gene expression [Transcription]; Region: AbrB; COG2002 991791001474 SpoVT / AbrB like domain; Region: SpoVT_AbrB; smart00966 991791001475 tRNA nucleotidyltransferase/poly(A) polymerase [Translation, ribosomal structure and biogenesis]; Region: PcnB; COG0617 991791001476 Nucleotidyltransferase (NT) domain of ClassII CCA-adding enzymes; Region: NT_ClassII-CCAase; cd05398 991791001477 active site 991791001478 NTP binding site [chemical binding]; other site 991791001479 metal binding triad [ion binding]; metal-binding site 991791001480 CRISPR/Cas system-associated protein Cas3'' Region: Cas3''_I; cl17503 991791001481 Phage shock protein A (IM30), suppresses sigma54-dependent transcription [Transcription / Signal transduction mechanisms]; Region: PspA; COG1842 991791001482 Domain of unknown function (DUF1836); Region: DUF1836; pfam08876 991791001483 Predicted acetyltransferase [General function prediction only]; Region: COG3981 991791001484 Acetyltransferase (GNAT) domain; Region: Acetyltransf_3; pfam13302 991791001485 ornithine carbamoyltransferase; Validated; Region: PRK02102 991791001486 Aspartate/ornithine carbamoyltransferase, carbamoyl-P binding domain; Region: OTCace_N; pfam02729 991791001487 Aspartate/ornithine carbamoyltransferase, Asp/Orn binding domain; Region: OTCace; pfam00185 991791001488 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 991791001489 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 991791001490 dimerization interface [polypeptide binding]; other site 991791001491 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 991791001492 dimer interface [polypeptide binding]; other site 991791001493 phosphorylation site [posttranslational modification] 991791001494 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 991791001495 ATP binding site [chemical binding]; other site 991791001496 G-X-G motif; other site 991791001497 RND family efflux transporter, MFP subunit; Region: RND_mfp; TIGR01730 991791001498 HlyD family secretion protein; Region: HlyD_3; pfam13437 991791001499 ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255 991791001500 ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136 991791001501 Walker A/P-loop; other site 991791001502 ATP binding site [chemical binding]; other site 991791001503 Q-loop/lid; other site 991791001504 ABC transporter signature motif; other site 991791001505 Walker B; other site 991791001506 D-loop; other site 991791001507 H-loop/switch region; other site 991791001508 MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704 991791001509 ABC-type antimicrobial peptide transport system, permease component [Defense mechanisms]; Region: SalY; COG0577 991791001510 FtsX-like permease family; Region: FtsX; pfam02687 991791001511 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 991791001512 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 991791001513 active site 991791001514 phosphorylation site [posttranslational modification] 991791001515 intermolecular recognition site; other site 991791001516 dimerization interface [polypeptide binding]; other site 991791001517 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 991791001518 DNA binding site [nucleotide binding] 991791001519 EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2). The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948 991791001520 phosphate regulon sensor kinase PhoR; Region: phoR_proteo; TIGR02966 991791001521 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 991791001522 dimer interface [polypeptide binding]; other site 991791001523 phosphorylation site [posttranslational modification] 991791001524 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 991791001525 ATP binding site [chemical binding]; other site 991791001526 Mg2+ binding site [ion binding]; other site 991791001527 G-X-G motif; other site 991791001528 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 991791001529 non-specific DNA binding site [nucleotide binding]; other site 991791001530 salt bridge; other site 991791001531 sequence-specific DNA binding site [nucleotide binding]; other site 991791001532 Predicted membrane protein [Function unknown]; Region: COG1971 991791001533 recombination factor protein RarA; Reviewed; Region: PRK13342 991791001534 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 991791001535 Walker A motif; other site 991791001536 ATP binding site [chemical binding]; other site 991791001537 Walker B motif; other site 991791001538 arginine finger; other site 991791001539 MgsA AAA+ ATPase C terminal; Region: MgsA_C; pfam12002 991791001540 Peroxiredoxin [Posttranslational modification, protein turnover, chaperones]; Region: AhpC; COG0450 991791001541 Peroxiredoxin (PRX) family, Bacterioferritin comigratory protein (BCP) subfamily; composed of thioredoxin-dependent thiol peroxidases, widely expressed in pathogenic bacteria, that protect cells against toxicity from reactive oxygen species by reducing...; Region: PRX_BCP; cd03017 991791001542 catalytic triad [active] 991791001543 Protein of unknown function DUF45; Region: DUF45; pfam01863 991791001544 Cell division protein FtsI/penicillin-binding protein 2 [Cell envelope biogenesis, outer membrane]; Region: FtsI; COG0768 991791001545 Penicillin-binding Protein dimerisation domain; Region: PBP_dimer; pfam03717 991791001546 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; pfam00905 991791001547 prolipoprotein diacylglyceryl transferase; Reviewed; Region: PRK12437 991791001548 Predicted membrane protein [Function unknown]; Region: COG4684 991791001549 Protein of unknown function (DUF3816); Region: DUF3816; pfam12822 991791001550 Beta-mannanase [Carbohydrate transport and metabolism]; Region: ManB; COG4124 991791001551 LXG domain of WXG superfamily; Region: LXG; pfam04740 991791001552 NAD+--asparagine ADP-ribosyltransferase [Signal transduction mechanisms]; Region: COG5585 991791001553 A nuclease family of the HNH/ENDO VII superfamily with conserved AHH; Region: AHH; pfam14412 991791001554 NAD+--asparagine ADP-ribosyltransferase [Signal transduction mechanisms]; Region: COG5585 991791001555 Immunity protein Imm6; Region: Imm6; pfam14434 991791001556 Immunity protein Imm6; Region: Imm6; pfam14434 991791001557 NAD+--asparagine ADP-ribosyltransferase [Signal transduction mechanisms]; Region: COG5585 991791001558 VIP2; A family of actin-ADP-ribosylating toxin. A member of the Bacillus-prodiced vegetative insecticidal proteins (VIPs) possesses high specificity against the major insect pest, corn rootworms, and belongs to a classs of binary toxins and regulators of...; Region: VIP2; cd00233 991791001559 active site 991791001560 conformational flexibility of ligand binding pocket; other site 991791001561 ADP-ribosylating toxin turn-turn motif; other site 991791001562 ADP-ribosylglycohydrolase [Posttranslational modification, protein turnover, chaperones]; Region: DraG; COG1397 991791001563 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4304 991791001564 Uncharacterized conserved protein [Function unknown]; Region: COG1434 991791001565 YdcF-like. YdcF-like is a large family of mainly bacterial proteins, with a few members found in fungi, plants, and archaea. Escherichia coli YdcF has been shown to bind S-adenosyl-L-methionine (AdoMet), but a biochemical function has not been...; Region: YdcF-like; cd06259 991791001566 putative active site [active] 991791001567 5'-nucleotidase/2',3'-cyclic phosphodiesterase and related esterases [Nucleotide transport and metabolism]; Region: UshA; COG0737 991791001568 Escherichia coli UshA-like family, N-terminal metallophosphatase domain; Region: MPP_UshA_N_like; cd00845 991791001569 active site 991791001570 metal binding site [ion binding]; metal-binding site 991791001571 5'-nucleotidase, C-terminal domain; Region: 5_nucleotid_C; pfam02872 991791001572 5'-nucleotidase/2',3'-cyclic phosphodiesterase and related esterases [Nucleotide transport and metabolism]; Region: UshA; COG0737 991791001573 Escherichia coli CpdB and related proteins, N-terminal metallophosphatase domain; Region: MPP_CpdB_N; cd07410 991791001574 active site 991791001575 metal binding site [ion binding]; metal-binding site 991791001576 5'-nucleotidase, C-terminal domain; Region: 5_nucleotid_C; pfam02872 991791001577 Predicted integral membrane protein [Function unknown]; Region: COG5542 991791001578 Endopygalactorunase [Cell envelope biogenesis, outer membrane]; Region: PGU1; COG5434 991791001579 Probable polygalacturonase At3g15720; Region: PLN03003; cl14103 991791001580 Uncharacterized ACR, YkgG family COG1556; Region: DUF162; pfam02589 991791001581 Na+/melibiose symporter and related transporters [Carbohydrate transport and metabolism]; Region: MelB; COG2211 991791001582 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 991791001583 Predicted xylanase/chitin deacetylase [Carbohydrate transport and metabolism]; Region: CDA1; COG0726 991791001584 Putative catalytic NodB homology domain of gellan lyase and similar proteins; Region: CE4_GLA_like_6s; cd10967 991791001585 putative active site [active] 991791001586 putative metal binding site [ion binding]; other site 991791001587 Predicted unsaturated glucuronyl hydrolase involved in regulation of bacterial surface properties, and related proteins [General function prediction only]; Region: COG4225 991791001588 Transcriptional regulators [Transcription]; Region: PurR; COG1609 991791001589 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 991791001590 DNA binding site [nucleotide binding] 991791001591 domain linker motif; other site 991791001592 Ligand binding domain of the LacI tanscriptional regulator family belonging to the type I periplasmic-binding fold protein superfamily; Region: PBP1_LacI_sugar_binding_like; cd06267 991791001593 dimerization interface [polypeptide binding]; other site 991791001594 ligand binding site [chemical binding]; other site 991791001595 2-deoxy-D-gluconate 3-dehydrogenase; Provisional; Region: PRK06935 991791001596 gluconate 5-dehydrogenase (Ga5DH)-like, classical (c) SDRs; Region: Ga5DH-like_SDR_c; cd05347 991791001597 NADP binding site [chemical binding]; other site 991791001598 homodimer interface [polypeptide binding]; other site 991791001599 active site 991791001600 Hemerythrin HHE cation binding domain; Region: Hemerythrin; pfam01814 991791001601 Endonuclease_V, a DNA repair enzyme that initiates repair of nitrosative deaminated purine bases; Region: Endonuclease_V; cd06559 991791001602 Active_site [active] 991791001603 Metal-dependent hydrolases of the beta-lactamase superfamily III [General function prediction only]; Region: ElaC; COG1234 991791001604 Phosphoglycerate dehydrogenase and related dehydrogenases [Amino acid transport and metabolism]; Region: SerA; COG0111 991791001605 Phosphoglycerate Dehydrogenase, 2-hydroxyacid dehydrogenase family; Region: PGDH_1; cd12155 991791001606 putative ligand binding site [chemical binding]; other site 991791001607 NAD binding site [chemical binding]; other site 991791001608 catalytic site [active] 991791001609 Membrane transport protein; Region: Mem_trans; pfam03547 991791001610 M20 Peptidase Arginine utilization protein, RocB; Region: M20_ArgE_RocB; cd05654 991791001611 putative metal binding site [ion binding]; other site 991791001612 putative dimer interface [polypeptide binding]; other site 991791001613 4-aminobutyrate aminotransferase; Provisional; Region: PRK08117 991791001614 Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610 991791001615 inhibitor-cofactor binding pocket; inhibition site 991791001616 pyridoxal 5'-phosphate binding site [chemical binding]; other site 991791001617 catalytic residue [active] 991791001618 Acetyltransferase (GNAT) domain; Region: Acetyltransf_3; pfam13302 991791001619 Acetyltransferase (GNAT) family; Region: Acetyltransf_1; pfam00583 991791001620 Cation/multidrug efflux pump [Defense mechanisms]; Region: AcrB; COG0841 991791001621 Cation/multidrug efflux pump [Defense mechanisms]; Region: AcrB; COG0841 991791001622 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 991791001623 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 991791001624 active site 991791001625 phosphorylation site [posttranslational modification] 991791001626 intermolecular recognition site; other site 991791001627 dimerization interface [polypeptide binding]; other site 991791001628 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cl17355 991791001629 DNA binding site [nucleotide binding] 991791001630 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 991791001631 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 991791001632 ATP binding site [chemical binding]; other site 991791001633 Mg2+ binding site [ion binding]; other site 991791001634 G-X-G motif; other site 991791001635 ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136 991791001636 ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255 991791001637 Walker A/P-loop; other site 991791001638 ATP binding site [chemical binding]; other site 991791001639 Q-loop/lid; other site 991791001640 ABC transporter signature motif; other site 991791001641 Walker B; other site 991791001642 D-loop; other site 991791001643 H-loop/switch region; other site 991791001644 aminotransferase A; Validated; Region: PRK07683 991791001645 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 991791001646 pyridoxal 5'-phosphate binding site [chemical binding]; other site 991791001647 homodimer interface [polypeptide binding]; other site 991791001648 catalytic residue [active] 991791001649 N-Dimethylarginine dimethylaminohydrolase [Amino acid transport and metabolism]; Region: COG1834 991791001650 Amidinotransferase; Region: Amidinotransf; pfam02274 991791001651 ABC-type arginine transport system, permease component [Amino acid transport and metabolism]; Region: ArtQ; COG4215 991791001652 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 991791001653 dimer interface [polypeptide binding]; other site 991791001654 conserved gate region; other site 991791001655 putative PBP binding loops; other site 991791001656 ABC-ATPase subunit interface; other site 991791001657 ABC-type polar amino acid transport system, ATPase component [Amino acid transport and metabolism]; Region: GlnQ; COG1126 991791001658 ATP-binding cassette domain of the histidine and glutamine transporters; Region: ABC_HisP_GlnQ; cd03262 991791001659 Walker A/P-loop; other site 991791001660 ATP binding site [chemical binding]; other site 991791001661 Q-loop/lid; other site 991791001662 ABC transporter signature motif; other site 991791001663 Walker B; other site 991791001664 D-loop; other site 991791001665 H-loop/switch region; other site 991791001666 Transcriptional regulators [Transcription]; Region: GntR; COG1802 991791001667 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 991791001668 DNA-binding site [nucleotide binding]; DNA binding site 991791001669 FCD domain; Region: FCD; pfam07729 991791001670 Bacterial extracellular solute-binding proteins, family 3; Region: SBP_bac_3; pfam00497 991791001671 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 991791001672 substrate binding pocket [chemical binding]; other site 991791001673 membrane-bound complex binding site; other site 991791001674 hinge residues; other site 991791001675 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 991791001676 dimer interface [polypeptide binding]; other site 991791001677 putative CheW interface [polypeptide binding]; other site 991791001678 Adenosine deaminase z-alpha domain; Region: z-alpha; cl02659 991791001679 Transcriptional regulators containing an AAA-type ATPase domain and a DNA-binding domain [Transcription / Signal transduction mechanisms]; Region: PspF; COG1221 991791001680 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 991791001681 Walker A motif; other site 991791001682 ATP binding site [chemical binding]; other site 991791001683 Walker B motif; other site 991791001684 arginine finger; other site 991791001685 Transcriptional antiterminator [Transcription]; Region: COG3933 991791001686 PRD domain; Region: PRD; pfam00874 991791001687 PTS_IIA, PTS system, mannose/sorbose specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIA_man; cd00006 991791001688 active pocket/dimerization site; other site 991791001689 active site 991791001690 phosphorylation site [posttranslational modification] 991791001691 PRD domain; Region: PRD; pfam00874 991791001692 PTS_IIA, PTS system, lactose/cellobiose specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_lac; cd00215 991791001693 active site 991791001694 methionine cluster; other site 991791001695 phosphorylation site [posttranslational modification] 991791001696 metal binding site [ion binding]; metal-binding site 991791001697 PTS_IIB_chitobiose_lichenan: subunit IIB of enzyme II (EII) of the N,N-diacetylchitobiose-specific and lichenan-specific phosphoenolpyruvate:carbohydrate phosphotransferase system (PTS). In these systems, EII is either a lichenan- or an N; Region: PTS_IIB_chitobiose_lichenan; cd05564 991791001698 active site 991791001699 P-loop; other site 991791001700 phosphorylation site [posttranslational modification] 991791001701 Beta-glucosidase/6-phospho-beta-glucosidase/beta- galactosidase [Carbohydrate transport and metabolism]; Region: BglB; COG2723 991791001702 beta-galactosidase; Region: BGL; TIGR03356 991791001703 Phosphotransferase system cellobiose-specific component IIC [Carbohydrate transport and metabolism]; Region: CelB; COG1455 991791001704 cellobiose phosphotransferase system IIC component; Reviewed; Region: celD; PRK09592 991791001705 Cystathionine beta-lyases/cystathionine gamma-synthases [Amino acid transport and metabolism]; Region: MetC; COG0626 991791001706 CGS_like: Cystathionine gamma-synthase is a PLP dependent enzyme and catalyzes the committed step of methionine biosynthesis. This pathway is unique to microorganisms and plants, rendering the enzyme an attractive target for the development of...; Region: CGS_like; cd00614 991791001707 homodimer interface [polypeptide binding]; other site 991791001708 substrate-cofactor binding pocket; other site 991791001709 pyridoxal 5'-phosphate binding site [chemical binding]; other site 991791001710 catalytic residue [active] 991791001711 Cystathionine beta-lyases/cystathionine gamma-synthases [Amino acid transport and metabolism]; Region: MetC; COG0626 991791001712 CGS_like: Cystathionine gamma-synthase is a PLP dependent enzyme and catalyzes the committed step of methionine biosynthesis. This pathway is unique to microorganisms and plants, rendering the enzyme an attractive target for the development of...; Region: CGS_like; cd00614 991791001713 homodimer interface [polypeptide binding]; other site 991791001714 substrate-cofactor binding pocket; other site 991791001715 pyridoxal 5'-phosphate binding site [chemical binding]; other site 991791001716 catalytic residue [active] 991791001717 Putative peptidoglycan-binding domain-containing protein [Cell envelope biogenesis, outer membrane]; Region: COG3409 991791001718 Putative peptidoglycan binding domain; Region: PG_binding_1; pfam01471 991791001719 Transcriptional regulators [Transcription]; Region: PurR; COG1609 991791001720 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 991791001721 DNA binding site [nucleotide binding] 991791001722 domain linker motif; other site 991791001723 Ligand-binding domain of DNA transcription repressor RegR and other putative regulators such as KdgR and EndR; Region: PBP1_RegR_EndR_KdgR_like; cd06283 991791001724 putative dimerization interface [polypeptide binding]; other site 991791001725 putative ligand binding site [chemical binding]; other site 991791001726 2-keto-3-deoxy-6-phosphogluconate aldolase [Carbohydrate transport and metabolism]; Region: Eda; COG0800 991791001727 KDPG and KHG aldolase; Region: KDPG_aldolase; cd00452 991791001728 active site 991791001729 intersubunit interface [polypeptide binding]; other site 991791001730 catalytic residue [active] 991791001731 2-keto-3-deoxygluconate kinase (KdgK) phosphorylates 2-keto-3-deoxygluconate (KDG) to form 2-keto-3-deoxy-6-phosphogluconate (KDGP). KDG is the common intermediate product, that allows organisms to channel D-glucuronate and/or D-galacturinate into the...; Region: KdgK; cd01166 991791001732 Sugar kinases, ribokinase family [Carbohydrate transport and metabolism]; Region: RbsK; COG0524 991791001733 substrate binding site [chemical binding]; other site 991791001734 ATP binding site [chemical binding]; other site 991791001735 3-Keto-L-gulonate 6-phosphate decarboxylase (KGPDC) and D-arabino-3-hexulose-6-phosphate synthase (HPS). KGPDC catalyzes the formation of L-xylulose 5-phosphate and carbon dioxide from 3-keto-L-gulonate 6-phosphate as part of the anaerobic pathway for...; Region: KGPDC_HPS; cd04726 991791001736 active site 991791001737 dimer interface [polypeptide binding]; other site 991791001738 magnesium binding site [ion binding]; other site 991791001739 Hexulose-6-phosphate isomerase (PHI). PHI is a member of the SIS (Sugar ISomerase domain) superfamily. In the ribulose monophosphate pathway of formaldehyde fixation, hexulose-6-phosphate synthase catalyzes the condensation of ribulose-5-phosphate with...; Region: SIS_PHI; cd05005 991791001740 Transcriptional regulators [Transcription]; Region: RpiR; COG1737 991791001741 tetramer interface [polypeptide binding]; other site 991791001742 active site 991791001743 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4842 991791001744 Bacterial Ig-like domain (group 3); Region: Big_3_3; pfam13750 991791001745 Bacterial Ig-like domain (group 3); Region: Big_3_4; pfam13754 991791001746 Bacterial Ig-like domain (group 3); Region: Big_3_4; pfam13754 991791001747 Bacterial Ig-like domain (group 3); Region: Big_3_4; pfam13754 991791001748 Protein Kinases, catalytic domain; Region: PKc_like; cl09925 991791001749 Protein kinase domain; Region: Pkinase; pfam00069 991791001750 active site 991791001751 ATP binding site [chemical binding]; other site 991791001752 substrate binding site [chemical binding]; other site 991791001753 activation loop (A-loop); other site 991791001754 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 991791001755 TPR motif; other site 991791001756 binding surface 991791001757 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 991791001758 binding surface 991791001759 TPR motif; other site 991791001760 FOG: FHA domain [Signal transduction mechanisms]; Region: COG1716 991791001761 Forkhead associated domain (FHA); found in eukaryotic and prokaryotic proteins. Putative nuclear signalling domain. FHA domains may bind phosphothreonine, phosphoserine and sometimes phosphotyrosine. In eukaryotes, many FHA domain-containing proteins...; Region: FHA; cd00060 991791001762 phosphopeptide binding site; other site 991791001763 Serine/threonine phosphatases, family 2C, catalytic domain; The protein architecture and deduced catalytic mechanism of PP2C phosphatases are similar to the PP1, PP2A, PP2B family of protein Ser/Thr phosphatases, with which PP2C shares no sequence...; Region: PP2Cc; cd00143 991791001764 active site 991791001765 FOG: FHA domain [Signal transduction mechanisms]; Region: COG1716 991791001766 Forkhead associated domain (FHA); found in eukaryotic and prokaryotic proteins. Putative nuclear signalling domain. FHA domains may bind phosphothreonine, phosphoserine and sometimes phosphotyrosine. In eukaryotes, many FHA domain-containing proteins...; Region: FHA; cd00060 991791001767 phosphopeptide binding site; other site 991791001768 type VII secretion protein EssC, C-terminal domain; Region: T7_EssCb_Firm; TIGR03928 991791001769 FtsK/SpoIIIE family; Region: FtsK_SpoIIIE; pfam01580 991791001770 FtsK/SpoIIIE family; Region: FtsK_SpoIIIE; pfam01580 991791001771 WXG100 protein secretion system (Wss), protein YukD; Region: YukD; cl17489 991791001772 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4842 991791001773 WXG100 family type VII secretion target; Region: WXG100_ESAT6; TIGR03930 991791001774 TPR repeat; Region: TPR_11; pfam13414 991791001775 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 991791001776 binding surface 991791001777 TPR motif; other site 991791001778 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 991791001779 binding surface 991791001780 TPR motif; other site 991791001781 TPR repeat; Region: TPR_11; pfam13414 991791001782 Tetratricopeptide repeat; Region: TPR_16; pfam13432 991791001783 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 991791001784 binding surface 991791001785 TPR motif; other site 991791001786 TPR repeat; Region: TPR_11; pfam13414 991791001787 TPR repeat; Region: TPR_11; pfam13414 991791001788 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4842 991791001789 TPR repeat; Region: TPR_11; pfam13414 991791001790 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 991791001791 binding surface 991791001792 TPR motif; other site 991791001793 TPR repeat; Region: TPR_11; pfam13414 991791001794 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 991791001795 binding surface 991791001796 TPR motif; other site 991791001797 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 991791001798 TPR motif; other site 991791001799 binding surface 991791001800 TPR repeat; Region: TPR_11; pfam13414 991791001801 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 991791001802 binding surface 991791001803 TPR motif; other site 991791001804 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 991791001805 binding surface 991791001806 TPR motif; other site 991791001807 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 991791001808 TPR repeat; Region: TPR_11; pfam13414 991791001809 binding surface 991791001810 TPR motif; other site 991791001811 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 991791001812 binding surface 991791001813 TPR motif; other site 991791001814 TPR repeat; Region: TPR_11; pfam13414 991791001815 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 991791001816 binding surface 991791001817 Tetratricopeptide repeat; Region: TPR_16; pfam13432 991791001818 TPR motif; other site 991791001819 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 991791001820 binding surface 991791001821 TPR motif; other site 991791001822 Arsenate Reductase (ArsC) family; composed of TRX-fold arsenic reductases and similar proteins including the transcriptional regulator, Spx. ArsC catalyzes the reduction of arsenate [As(V)] to arsenite [As(III)], using reducing equivalents derived from...; Region: ArsC_family; cd02977 991791001823 ArsC family; Region: ArsC; pfam03960 991791001824 catalytic residue [active] 991791001825 Predicted phosphatases [General function prediction only]; Region: Gph; COG0546 991791001826 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 991791001827 motif II; other site 991791001828 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cl00075 991791001829 G-X-G motif; other site 991791001830 Transmembrane protein 55A; Region: Tmemb_55A; pfam09788 991791001831 CAAX protease self-immunity; Region: Abi; pfam02517 991791001832 Protein of unknown function (DUF3816); Region: DUF3816; pfam12822 991791001833 transcriptional antiterminator BglG; Provisional; Region: PRK09772 991791001834 CAT RNA binding domain; Region: CAT_RBD; smart01061 991791001835 PRD domain; Region: PRD; pfam00874 991791001836 PRD domain; Region: PRD; pfam00874 991791001837 PTS system, sucrose-specific IIBC component; Region: PTS-II-BC-sucr; TIGR01996 991791001838 PTS_IIB, PTS system, glucose/sucrose specific IIB subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIB_glc; cd00212 991791001839 active site turn [active] 991791001840 phosphorylation site [posttranslational modification] 991791001841 Phosphotransferase system IIC components, glucose/maltose/N-acetylglucosamine-specific [Carbohydrate transport and metabolism]; Region: PtsG; COG1263 991791001842 Phosphotransferase system IIA components [Carbohydrate transport and metabolism]; Region: NagE; COG2190 991791001843 HPr interaction site; other site 991791001844 glycerol kinase (GK) interaction site [polypeptide binding]; other site 991791001845 active site 991791001846 phosphorylation site [posttranslational modification] 991791001847 Sugar kinases, ribokinase family [Carbohydrate transport and metabolism]; Region: RbsK; COG0524 991791001848 Fructokinases (FRKs) mainly from bacteria and plants are enzymes with high specificity for fructose, as are all FRKs, but they catalyzes the conversion of fructose to fructose-6-phosphate, which is an entry point into glycolysis via conversion into...; Region: bac_FRK; cd01167 991791001849 putative substrate binding site [chemical binding]; other site 991791001850 putative ATP binding site [chemical binding]; other site 991791001851 sucrose-6-phosphate hydrolase; Region: scrB_fam; TIGR01322 991791001852 Glycosyl hydrolase family 32, beta-fructosidases; Region: GH32_B_Fructosidase; cd08996 991791001853 substrate binding [chemical binding]; other site 991791001854 active site 991791001855 Glycosyl hydrolases family 32 C terminal; Region: Glyco_hydro_32C; pfam08244 991791001856 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 991791001857 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 991791001858 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3708 991791001859 ABC-type polysaccharide transport system, permease component [Carbohydrate transport and metabolism]; Region: LplB; COG4209 991791001860 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 991791001861 dimer interface [polypeptide binding]; other site 991791001862 conserved gate region; other site 991791001863 putative PBP binding loops; other site 991791001864 ABC-ATPase subunit interface; other site 991791001865 ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395 991791001866 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 991791001867 dimer interface [polypeptide binding]; other site 991791001868 conserved gate region; other site 991791001869 putative PBP binding loops; other site 991791001870 ABC-ATPase subunit interface; other site 991791001871 ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653 991791001872 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; cl17199 991791001873 Glycerophosphoryl diester phosphodiesterase [Energy production and conversion]; Region: UgpQ; COG0584 991791001874 Glycerophosphodiester phosphodiesterase domain of Thermoanaerobacter tengcongensis and similar proteins; Region: GDPD_TtGDE_like; cd08563 991791001875 active site 991791001876 catalytic site [active] 991791001877 metal binding site [ion binding]; metal-binding site 991791001878 dimer interface [polypeptide binding]; other site 991791001879 Uncharacterized conserved protein [Function unknown]; Region: COG1284 991791001880 Uncharacterized BCR, YitT family COG1284; Region: DUF161; pfam02588 991791001881 Uncharacterized protein conserved in bacteria (DUF2179); Region: DUF2179; pfam10035 991791001882 Predicted sensor domain [Signal transduction mechanisms / Transcription]; Region: PocR; COG4936 991791001883 Sensory domain found in PocR; Region: PocR; pfam10114 991791001884 Methyl-accepting chemotaxis protein [Cell motility and secretion / Signal transduction mechanisms]; Region: Tar; COG0840 991791001885 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 991791001886 dimer interface [polypeptide binding]; other site 991791001887 putative CheW interface [polypeptide binding]; other site 991791001888 Methyl-accepting chemotaxis protein [Cell motility and secretion / Signal transduction mechanisms]; Region: Tar; COG0840 991791001889 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 991791001890 dimer interface [polypeptide binding]; other site 991791001891 putative CheW interface [polypeptide binding]; other site 991791001892 MECDP_synthase (2-C-methyl-D-erythritol-2,4-cyclodiphosphate synthase), encoded by the ispF gene, catalyzes the formation of 2-C-methyl-D-erythritol 2,4-cyclodiphosphate (MEC) in the non-mevalonate deoxyxylulose (DOXP) pathway for isoprenoid biosynthesis; Region: MECDP_synthase; cd00554 991791001893 homotrimer interaction site [polypeptide binding]; other site 991791001894 zinc binding site [ion binding]; other site 991791001895 CDP-binding sites; other site 991791001896 Predicted xylanase/chitin deacetylase [Carbohydrate transport and metabolism]; Region: CDA1; COG0726 991791001897 Putative catalytic NodB homology domain of PgaB, IcaB, and similar proteins which consist of a deformed (beta/alpha)8 barrel fold with 5- or 6-strands; Region: CE4_NodB_like_5s_6s; cd10918 991791001898 putative active site [active] 991791001899 putative metal binding site [ion binding]; other site 991791001900 PAS domain S-box; Region: sensory_box; TIGR00229 991791001901 PAS domain; Region: PAS_8; pfam13188 991791001902 phosphate regulon sensor kinase PhoR; Region: phoR_proteo; TIGR02966 991791001903 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 991791001904 dimer interface [polypeptide binding]; other site 991791001905 phosphorylation site [posttranslational modification] 991791001906 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 991791001907 ATP binding site [chemical binding]; other site 991791001908 Mg2+ binding site [ion binding]; other site 991791001909 G-X-G motif; other site 991791001910 Predicted periplasmic or secreted lipoprotein [General function prediction only]; Region: OsmY; COG2823 991791001911 BON domain; Region: BON; pfam04972 991791001912 BON domain; Region: BON; pfam04972 991791001913 Uncharacterized conserved protein [Function unknown]; Region: COG1434 991791001914 YdcF-like. YdcF-like is a large family of mainly bacterial proteins, with a few members found in fungi, plants, and archaea. Escherichia coli YdcF has been shown to bind S-adenosyl-L-methionine (AdoMet), but a biochemical function has not been...; Region: YdcF-like; cd06259 991791001915 putative active site [active] 991791001916 Chloride channel protein EriC [Inorganic ion transport and metabolism]; Region: EriC; COG0038 991791001917 CLC voltage-gated chloride channel. The ClC chloride channels catalyse the selective flow of Cl- ions across cell membranes, thereby regulating electrical excitation in skeletal muscle and the flow of salt and water across epithelial barriers. This...; Region: Voltage_gated_ClC; cd00400 991791001918 Cl- selectivity filter; other site 991791001919 Cl- binding residues [ion binding]; other site 991791001920 pore gating glutamate residue; other site 991791001921 dimer interface [polypeptide binding]; other site 991791001922 Four helix bundle sensory module for signal transduction; Region: 4HB_MCP_1; pfam12729 991791001923 Methyl-accepting chemotaxis protein [Cell motility and secretion / Signal transduction mechanisms]; Region: Tar; COG0840 991791001924 HAMP domain; Region: HAMP; pfam00672 991791001925 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 991791001926 dimer interface [polypeptide binding]; other site 991791001927 putative CheW interface [polypeptide binding]; other site 991791001928 Kef-type K+ transport systems, membrane components [Inorganic ion transport and metabolism]; Region: KefB; COG0475 991791001929 Sodium/hydrogen exchanger family; Region: Na_H_Exchanger; pfam00999 991791001930 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 991791001931 helix_turn_helix, Lux Regulon; Region: HTH_LUXR; smart00421 991791001932 DNA binding residues [nucleotide binding] 991791001933 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3860 991791001934 Members of the Nudix hydrolase superfamily catalyze the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+, for their activity and contain a highly...; Region: Nudix_Hydrolase_33; cd04692 991791001935 nudix motif; other site 991791001936 Fe2+ transport system protein A [Inorganic ion transport and metabolism]; Region: FeoA; COG1918 991791001937 Fe2+ transport system protein B [Inorganic ion transport and metabolism]; Region: FeoB; COG0370 991791001938 Ferrous iron transport protein B (FeoB) family; Region: FeoB; cd01879 991791001939 G1 box; other site 991791001940 GTP/Mg2+ binding site [chemical binding]; other site 991791001941 Switch I region; other site 991791001942 G2 box; other site 991791001943 G3 box; other site 991791001944 Switch II region; other site 991791001945 G4 box; other site 991791001946 G5 box; other site 991791001947 Nucleoside recognition; Region: Gate; pfam07670 991791001948 Ferrous iron transport protein B C terminus; Region: FeoB_C; pfam07664 991791001949 Nucleoside recognition; Region: Gate; pfam07670 991791001950 Protein of unknown function (DUF3189); Region: DUF3189; pfam11385 991791001951 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 991791001952 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 991791001953 active site 991791001954 phosphorylation site [posttranslational modification] 991791001955 intermolecular recognition site; other site 991791001956 dimerization interface [polypeptide binding]; other site 991791001957 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 991791001958 DNA binding site [nucleotide binding] 991791001959 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 991791001960 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 991791001961 dimerization interface [polypeptide binding]; other site 991791001962 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 991791001963 dimer interface [polypeptide binding]; other site 991791001964 phosphorylation site [posttranslational modification] 991791001965 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 991791001966 ATP binding site [chemical binding]; other site 991791001967 Mg2+ binding site [ion binding]; other site 991791001968 G-X-G motif; other site 991791001969 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 991791001970 putative substrate translocation pore; other site 991791001971 ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136 991791001972 ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255 991791001973 Walker A/P-loop; other site 991791001974 ATP binding site [chemical binding]; other site 991791001975 Q-loop/lid; other site 991791001976 ABC transporter signature motif; other site 991791001977 Walker B; other site 991791001978 D-loop; other site 991791001979 H-loop/switch region; other site 991791001980 ABC-type transport system, involved in lipoprotein release, permease component [Cell envelope biogenesis, outer membrane]; Region: LolE; COG4591 991791001981 MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704 991791001982 FtsX-like permease family; Region: FtsX; pfam02687 991791001983 ABC-type antimicrobial peptide transport system, permease component [Defense mechanisms]; Region: SalY; COG0577 991791001984 FtsX-like permease family; Region: FtsX; pfam02687 991791001985 ATP-dependent Lon protease, bacterial type [Posttranslational modification, protein turnover, chaperones]; Region: Lon; COG0466 991791001986 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 991791001987 Walker A motif; other site 991791001988 ATP binding site [chemical binding]; other site 991791001989 Walker B motif; other site 991791001990 arginine finger; other site 991791001991 Lon protease (S16) C-terminal proteolytic domain; Region: Lon_C; pfam05362 991791001992 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 991791001993 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 991791001994 H+ Antiporter protein; Region: 2A0121; TIGR00900 991791001995 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 991791001996 putative substrate translocation pore; other site 991791001997 Propionate catabolism activator; Region: PrpR_N; pfam06506 991791001998 Transcriptional regulator containing PAS, AAA-type ATPase, and DNA-binding domains [Transcription / Signal transduction mechanisms]; Region: RocR; COG3829 991791001999 PAS domain; Region: PAS; smart00091 991791002000 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 991791002001 Walker A motif; other site 991791002002 ATP binding site [chemical binding]; other site 991791002003 Walker B motif; other site 991791002004 arginine finger; other site 991791002005 Bacterial regulatory protein, Fis family; Region: HTH_8; pfam02954 991791002006 Hemolysins and related proteins containing CBS domains [General function prediction only]; Region: TlyC; COG1253 991791002007 Domain of unknown function DUF21; Region: DUF21; pfam01595 991791002008 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains associated with the CorC_HlyC domain. CorC_HlyC is a transporter associated domain. This small domain is found in Na+/H+ antiporters, in proteins involved in...; Region: CBS_pair_CorC_HlyC_assoc; cd04590 991791002009 Helix-Turn-Helix DNA binding domain of Heavy Metal Resistance transcription regulators; Region: HTH_HMRTR; cd04770 991791002010 Predicted transcriptional regulators [Transcription]; Region: SoxR; COG0789 991791002011 DNA binding residues [nucleotide binding] 991791002012 dimer interface [polypeptide binding]; other site 991791002013 metal binding site [ion binding]; metal-binding site 991791002014 Uncharacterized paraquat-inducible protein B [Function unknown]; Region: COG3007 991791002015 NAD(P)H binding domain of trans-2-enoyl-CoA reductase; Region: Eno-Rase_NADH_b; pfam12242 991791002016 Trans-2-enoyl-CoA reductase catalytic region; Region: Enoyl_reductase; pfam12241 991791002017 Enoyl reductase FAD binding domain; Region: Eno-Rase_FAD_bd; pfam07055 991791002018 periplasmic serine pepetdase DegS; Region: protease_degS; TIGR02038 991791002019 Trypsin-like peptidase domain; Region: Trypsin_2; pfam13365 991791002020 PDZ domain of tryspin-like serine proteases, such as DegP/HtrA, which are oligomeric proteins involved in heat-shock response, chaperone function, and apoptosis. May be responsible for substrate recognition and/or binding, as most PDZ domains bind...; Region: PDZ_serine_protease; cd00987 991791002021 protein binding site [polypeptide binding]; other site 991791002022 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3323 991791002023 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 991791002024 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 991791002025 non-specific DNA binding site [nucleotide binding]; other site 991791002026 salt bridge; other site 991791002027 sequence-specific DNA binding site [nucleotide binding]; other site 991791002028 Protein of unknown function (DUF2837); Region: DUF2837; pfam10997 991791002029 haloacid dehalogenase superfamily, subfamily IA, variant 3 with third motif having DD or ED; Region: HAD-SF-IA-v3; TIGR01509 991791002030 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 991791002031 motif II; other site 991791002032 Uncharacterized membrane protein, required for spore maturation in B.subtilis. [General function prediction only]; Region: SpmA; COG2715 991791002033 Uncharacterized membrane protein [Function unknown]; Region: SpmB; COG0700 991791002034 Molecular chaperone GrpE (heat shock protein) [Posttranslational modification, protein turnover, chaperones]; Region: GrpE; COG0576 991791002035 GrpE is the adenine nucleotide exchange factor of DnaK (Hsp70)-type ATPases. The GrpE dimer binds to the ATPase domain of Hsp70 catalyzing the dissociation of ADP, which enables rebinding of ATP, one step in the Hsp70 reaction cycle in protein folding; Region: GrpE; cl03075 991791002036 hsp70 (ATPase domain) interactions [polypeptide binding]; other site 991791002037 Molecular chaperone [Posttranslational modification, protein turnover, chaperones]; Region: DnaK; COG0443 991791002038 Nucleotide-binding domain of the HSP70 family; Region: HSP70_NBD; cd10170 991791002039 nucleotide binding site [chemical binding]; other site 991791002040 putative NEF/HSP70 interaction site [polypeptide binding]; other site 991791002041 SBD interface [polypeptide binding]; other site 991791002042 Molecular chaperone [Posttranslational modification, protein turnover, chaperones]; Region: DnaK; COG0443 991791002043 Nucleotide-binding domain of the HSP70 family; Region: HSP70_NBD; cd10170 991791002044 nucleotide binding site [chemical binding]; other site 991791002045 putative NEF/HSP70 interaction site [polypeptide binding]; other site 991791002046 SBD interface [polypeptide binding]; other site 991791002047 Von Willebrand factor type A (vWA) domain was originally found in the blood coagulation protein von Willebrand factor (vWF). Typically, the vWA domain is made up of approximately 200 amino acid residues folded into a classic a/b para-rossmann type of...; Region: vWFA; cd00198 991791002048 metal ion-dependent adhesion site (MIDAS); other site 991791002049 Double zinc ribbon; Region: DZR; pfam12773 991791002050 c-di-GMP phosphodiesterase class II (HD-GYP domain) [Signal transduction mechanisms]; Region: COG2206 991791002051 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 991791002052 Zn2+ binding site [ion binding]; other site 991791002053 Mg2+ binding site [ion binding]; other site 991791002054 peptidase T; Region: peptidase-T; TIGR01882 991791002055 M20 Peptidase T specifically cleaves tripeptides; Region: M20_peptT; cd03892 991791002056 metal binding site [ion binding]; metal-binding site 991791002057 dimer interface [polypeptide binding]; other site 991791002058 Uncharacterized proteins of the AP superfamily [General function prediction only]; Region: COG1524 991791002059 Uncharacterized conserved protein [Function unknown]; Region: COG3379 991791002060 ACT domain proteins similar to the yet uncharacterized Streptococcus pneumoniae ACT domain protein; Region: ACT_1ZPV; cd04872 991791002061 Uncharacterized proteins with similarity to Ribonucleotide reductase and Pyruvate formate lyase; Region: RNR_PFL_like_DUF711; cd08025 991791002062 anaerobic ribonucleoside triphosphate reductase; Provisional; Region: PRK07111 991791002063 ATP cone domain; Region: ATP-cone; pfam03477 991791002064 Class III ribonucleotide reductase; Region: RNR_III; cd01675 991791002065 effector binding site; other site 991791002066 active site 991791002067 Zn binding site [ion binding]; other site 991791002068 glycine loop; other site 991791002069 4Fe-4S single cluster domain; Region: Fer4_12; pfam13353 991791002070 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 991791002071 FeS/SAM binding site; other site 991791002072 Predicted Zn-dependent hydrolases of the beta-lactamase fold [General function prediction only]; Region: COG2220 991791002073 Beta-lactamase superfamily domain; Region: Lactamase_B_3; pfam13483 991791002074 CAAX protease self-immunity; Region: Abi; pfam02517 991791002075 phosphoglucosamine mutase; Provisional; Region: glmM; PRK14316 991791002076 GlmM is a bacterial phosphoglucosamine mutase (PNGM) that belongs to the alpha-D-phosphohexomutase superfamily. It is required for the interconversion of glucosamine-6-phosphate and glucosamine-1-phosphate in the biosynthetic pathway of...; Region: GlmM; cd05802 991791002077 active site 991791002078 substrate binding site [chemical binding]; other site 991791002079 metal binding site [ion binding]; metal-binding site 991791002080 Ribonuclease BN family enzyme [Replication, recombination, and repair]; Region: Rbn; COG1295 991791002081 putative iron-only hydrogenase system regulator; Region: hyd_TM1266; TIGR03959 991791002082 4'-phosphopantetheinyl transferase; Provisional; Region: acpS; PRK00070 991791002083 Uncharacterized conserved protein [Function unknown]; Region: COG0062 991791002084 putative carbohydrate kinase; Provisional; Region: PRK10565 991791002085 B.subtilis YXKO protein of unknown function and related proteins. Based on the conservation of the ATP binding site, the substrate binding site and the Mg2+binding site and structural homology this group is a member of the ribokinase-like superfamily; Region: YXKO-related; cd01171 991791002086 putative substrate binding site [chemical binding]; other site 991791002087 putative ATP binding site [chemical binding]; other site 991791002088 Outer membrane lipoprotein-sorting protein [Cell envelope biogenesis, outer membrane]; Region: LolA; COG2834 991791002089 alanine racemase; Reviewed; Region: alr; PRK00053 991791002090 Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzyme Alanine Racemase; Region: PLPDE_III_AR; cd00430 991791002091 active site 991791002092 pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site 991791002093 dimer interface [polypeptide binding]; other site 991791002094 substrate binding site [chemical binding]; other site 991791002095 catalytic residues [active] 991791002096 Predicted transcriptional regulators containing the CopG/Arc/MetJ DNA-binding domain and a metal-binding domain [Transcription]; Region: NikR; COG0864 991791002097 PemK-like protein; Region: PemK; pfam02452 991791002098 Thiamine monophosphate synthase (TMP synthase)/TenI. TMP synthase catalyzes an important step in the thiamine biosynthesis pathway, the substitution of the pyrophosphate of 2-methyl-4-amino-5- hydroxymethylpyrimidine pyrophosphate by 4-methyl-5-; Region: TMP_TenI; cd00564 991791002099 thiamine phosphate binding site [chemical binding]; other site 991791002100 active site 991791002101 pyrophosphate binding site [ion binding]; other site 991791002102 Uncharacterized conserved protein [Function unknown]; Region: COG1284 991791002103 Uncharacterized BCR, YitT family COG1284; Region: DUF161; pfam02588 991791002104 Uncharacterized BCR, YitT family COG1284; Region: DUF161; pfam02588 991791002105 Uncharacterized protein conserved in bacteria (DUF2179); Region: DUF2179; pfam10035 991791002106 Predicted ATPase involved in cell division [Cell division and chromosome partitioning]; Region: FtsE; COG2884 991791002107 ATP-binding cassette domain of the cell division transporter; Region: ABC_FtsE_transporter; cd03292 991791002108 Walker A/P-loop; other site 991791002109 ATP binding site [chemical binding]; other site 991791002110 Q-loop/lid; other site 991791002111 ABC transporter signature motif; other site 991791002112 Walker B; other site 991791002113 D-loop; other site 991791002114 H-loop/switch region; other site 991791002115 Cell division protein [Cell division and chromosome partitioning]; Region: FtsX; COG2177 991791002116 cell division ABC transporter subunit FtsX; Provisional; Region: ftsX; PRK11026 991791002117 Periplasmic protease [Cell envelope biogenesis, outer membrane]; Region: Prc; COG0793 991791002118 C-terminal processing peptidase family S41; Region: Peptidase_S41; cl02526 991791002119 PDZ domain of C-terminal processing-, tail-specific-, and tricorn proteases, which function in posttranslational protein processing, maturation, and disassembly or degradation, in Bacteria, Archaea, and plant chloroplasts. May be responsible for...; Region: PDZ_CTP_protease; cd00988 991791002120 protein binding site [polypeptide binding]; other site 991791002121 C-terminal processing peptidase; serine protease family S41; Region: Peptidase_S41_CPP; cd07560 991791002122 Catalytic dyad [active] 991791002123 Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain [Posttranslational modification, protein turnover, chaperones]; Region: DegQ; COG0265 991791002124 PDZ domain of tryspin-like serine proteases, such as DegP/HtrA, which are oligomeric proteins involved in heat-shock response, chaperone function, and apoptosis. May be responsible for substrate recognition and/or binding, as most PDZ domains bind...; Region: PDZ_serine_protease; cd00987 991791002125 undecaprenyl pyrophosphate phosphatase; Reviewed; Region: PRK00281 991791002126 excinuclease ABC subunit B; Provisional; Region: PRK05298 991791002127 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 991791002128 ATP binding site [chemical binding]; other site 991791002129 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cl17251 991791002130 putative Mg++ binding site [ion binding]; other site 991791002131 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 991791002132 nucleotide binding region [chemical binding]; other site 991791002133 ATP-binding site [chemical binding]; other site 991791002134 Ultra-violet resistance protein B; Region: UvrB; pfam12344 991791002135 excinuclease ABC subunit A; Reviewed; Region: uvrA; PRK00349 991791002136 ATP-binding cassette domain I of the excision repair protein UvrA; Region: ABC_UvrA_I; cd03270 991791002137 ATP-binding cassette domain I of the excision repair protein UvrA; Region: ABC_UvrA_I; cd03270 991791002138 ATP-binding cassette domain II of the excision repair protein UvrA; Region: ABC_UvrA_II; cd03271 991791002139 FOG: FHA domain [Signal transduction mechanisms]; Region: COG1716 991791002140 Forkhead associated domain (FHA); found in eukaryotic and prokaryotic proteins. Putative nuclear signalling domain. FHA domains may bind phosphothreonine, phosphoserine and sometimes phosphotyrosine. In eukaryotes, many FHA domain-containing proteins...; Region: FHA; cd00060 991791002141 phosphopeptide binding site; other site 991791002142 Bacterial cell division membrane protein [Cell division and chromosome partitioning]; Region: FtsW; COG0772 991791002143 Cell division protein FtsI/penicillin-binding protein 2 [Cell envelope biogenesis, outer membrane]; Region: FtsI; COG0768 991791002144 Penicillin-binding Protein dimerisation domain; Region: PBP_dimer; pfam03717 991791002145 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; pfam00905 991791002146 Predicted membrane-bound metal-dependent hydrolases [General function prediction only]; Region: COG1988 991791002147 excinuclease ABC subunit C; Validated; Region: uvrC; PRK00558 991791002148 Catalytic GIY-YIG domain of nucleotide excision repair endonucleases UvrC, Cho, and similar proteins; Region: GIY-YIG_UvrC_Cho; cd10434 991791002149 GIY-YIG motif/motif A; other site 991791002150 active site 991791002151 catalytic site [active] 991791002152 putative DNA binding site [nucleotide binding]; other site 991791002153 metal binding site [ion binding]; metal-binding site 991791002154 UvrB/uvrC motif; Region: UVR; pfam02151 991791002155 UvrC Helix-hairpin-helix N-terminal; Region: UvrC_HhH_N; pfam08459 991791002156 H3TH domains of structure-specific 5' nucleases (or flap endonuclease-1-like) involved in DNA replication, repair, and recombination; Region: H3TH_StructSpec-5'-nucleases; cl14815 991791002157 putative hydrolase; Validated; Region: PRK09248 991791002158 Polymerase and Histidinol Phosphatase domain of Ycdx like; Region: PHP_HisPPase_Ycdx_like; cd07437 991791002159 active site 991791002160 UDP-N-acetylenolpyruvoylglucosamine reductase; Provisional; Region: murB; PRK13905 991791002161 FAD binding domain; Region: FAD_binding_4; pfam01565 991791002162 UDP-N-acetylenolpyruvoylglucosamine reductase, C-terminal domain; Region: MurB_C; pfam02873 991791002163 glmZ(sRNA)-inactivating NTPase; Provisional; Region: PRK05416 991791002164 AAA domain; Region: AAA_18; pfam13238 991791002165 conserved hypothetical protein, cofD-related; Region: CofD_related; TIGR01826 991791002166 family of mostly uncharacterized proteins similar to B.subtilis YvcK; Region: YvcK_like; cd07187 991791002167 phosphate binding site [ion binding]; other site 991791002168 putative substrate binding pocket [chemical binding]; other site 991791002169 dimer interface [polypeptide binding]; other site 991791002170 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG1481 991791002171 Sporulation Regulator WhiA N terminal; Region: WhiA_N; pfam10298 991791002172 Predicted transcriptional regulator containing CBS domains [Transcription]; Region: COG4109 991791002173 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 991791002174 DNA-binding site [nucleotide binding]; DNA binding site 991791002175 DRTGG domain; Region: DRTGG; pfam07085 991791002176 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains associated with a DRTGG domain upstream. The function of the DRTGG domain, named after its conserved residues, is unknown. CBS is a small domain originally...; Region: CBS_pair_DRTGG_assoc; cd04596 991791002177 The hotdog fold was initially identified in the E. coli FabA (beta-hydroxydecanoyl-acyl carrier protein (ACP)-dehydratase) structure and subsequently in 4HBT (4-hydroxybenzoyl-CoA thioesterase) from Pseudomonas. A number of other seemingly unrelated...; Region: hot_dog; cd03440 991791002178 active site 2 [active] 991791002179 Stress responsive A/B Barrel Domain; Region: Dabb; smart00886 991791002180 DNA polymerase III DnaE; Reviewed; Region: dnaE; PRK06826 991791002181 Polymerase and Histidinol Phosphatase domain of alpha-subunit of bacterial polymerase III DnaE3; Region: PHP_PolIIIA_DnaE3; cd12113 991791002182 active site 991791002183 PHP Thumb interface [polypeptide binding]; other site 991791002184 metal binding site [ion binding]; metal-binding site 991791002185 DnaE_OBF: A subfamily of OB folds corresponding to the C-terminal OB-fold nucleic acid binding domain of Thermus aquaticus and Escherichia coli type C replicative DNA polymerase III alpha subunit (DnaE). The DNA polymerase holoenzyme of E. coli contains...; Region: DnaE_OBF; cd04485 991791002186 generic binding surface II; other site 991791002187 generic binding surface I; other site 991791002188 6-phosphofructokinase; Provisional; Region: PRK03202 991791002189 6-phosphofructokinase; Region: PFKA_ATP; TIGR02482 991791002190 active site 991791002191 ADP/pyrophosphate binding site [chemical binding]; other site 991791002192 dimerization interface [polypeptide binding]; other site 991791002193 allosteric effector site; other site 991791002194 fructose-1,6-bisphosphate binding site; other site 991791002195 Pyruvate kinase [Carbohydrate transport and metabolism]; Region: PykF; COG0469 991791002196 Pyruvate kinase (PK): Large allosteric enzyme that regulates glycolysis through binding of the substrate, phosphoenolpyruvate, and one or more allosteric effectors. Like other allosteric enzymes, PK has a high substrate affinity R state and a low...; Region: Pyruvate_Kinase; cl17342 991791002197 domain interfaces; other site 991791002198 active site 991791002199 dihydroorotase; Validated; Region: pyrC; PRK09357 991791002200 Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281 991791002201 Dihydroorotase (DHOase), subgroup IIa; DHOases catalyze the reversible interconversion of carbamoyl aspartate to dihydroorotate, a key reaction in pyrimidine biosynthesis. This subgroup also contains proteins that lack the active site, like unc-33, a C; Region: DHOase_IIa; cd01317 991791002202 active site 991791002203 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 991791002204 NAD(P) binding site [chemical binding]; other site 991791002205 active site 991791002206 Domain of Unknown Function (DUF1540); Region: DUF1540; pfam07561 991791002207 Domain of Unknown Function (DUF1540); Region: DUF1540; pfam07561 991791002208 Predicted hydrolases of the HAD superfamily [General function prediction only]; Region: Cof; COG0561 991791002209 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 991791002210 active site 991791002211 motif I; other site 991791002212 motif II; other site 991791002213 Predicted RNA-binding protein, contains TRAM domain [General function prediction only]; Region: COG3269 991791002214 SAM-dependent methyltransferases related to tRNA (uracil-5-)-methyltransferase [Translation, ribosomal structure and biogenesis]; Region: TrmA; COG2265 991791002215 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 991791002216 S-adenosylmethionine binding site [chemical binding]; other site 991791002217 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 991791002218 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 991791002219 active site 991791002220 phosphorylation site [posttranslational modification] 991791002221 intermolecular recognition site; other site 991791002222 dimerization interface [polypeptide binding]; other site 991791002223 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 991791002224 DNA binding site [nucleotide binding] 991791002225 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 991791002226 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 991791002227 dimer interface [polypeptide binding]; other site 991791002228 phosphorylation site [posttranslational modification] 991791002229 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 991791002230 ATP binding site [chemical binding]; other site 991791002231 Mg2+ binding site [ion binding]; other site 991791002232 G-X-G motif; other site 991791002233 ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136 991791002234 ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255 991791002235 Walker A/P-loop; other site 991791002236 ATP binding site [chemical binding]; other site 991791002237 Q-loop/lid; other site 991791002238 ABC transporter signature motif; other site 991791002239 Walker B; other site 991791002240 D-loop; other site 991791002241 H-loop/switch region; other site 991791002242 MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704 991791002243 ABC-type antimicrobial peptide transport system, permease component [Defense mechanisms]; Region: SalY; COG0577 991791002244 FtsX-like permease family; Region: FtsX; pfam02687 991791002245 ABC-type antimicrobial peptide transport system, permease component [Defense mechanisms]; Region: SalY; COG0577 991791002246 FtsX-like permease family; Region: FtsX; pfam02687 991791002247 ATPase components of ABC transporters with duplicated ATPase domains [General function prediction only]; Region: Uup; COG0488 991791002248 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 991791002249 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 991791002250 Domain of unknown function (DUF303); Region: DUF303; pfam03629 991791002251 Predicted transcriptional regulators [Transcription]; Region: COG1695 991791002252 Transcriptional regulators [Transcription]; Region: RpiR; COG1737 991791002253 Helix-turn-helix domain, rpiR family; Region: HTH_6; pfam01418 991791002254 RpiR-like protein. RpiR contains a SIS (Sugar ISomerase) domain, which is found in many phosphosugar isomerases and phosphosugar binding proteins. In E. coli, rpiR negatively regulates the expression of rpiB gene. Both rpiB and rpiA are ribose phosphate...; Region: SIS_RpiR; cd05013 991791002255 putative active site [active] 991791002256 PTS system, alpha-glucoside-specific IIBC component; Region: PTS-IIBC-alpha; TIGR02005 991791002257 Phosphotransferase system IIC components, glucose/maltose/N-acetylglucosamine-specific [Carbohydrate transport and metabolism]; Region: PtsG; COG1263 991791002258 PTS_IIB, PTS system, glucose/sucrose specific IIB subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIB_glc; cd00212 991791002259 active site turn [active] 991791002260 phosphorylation site [posttranslational modification] 991791002261 Alpha-galactosidases/6-phospho-beta-glucosidases, family 4 of glycosyl hydrolases [Carbohydrate transport and metabolism]; Region: CelF; COG1486 991791002262 Glycoside Hydrolases Family 4; GlvA- and pagL-like glycosidases; Region: GH4_GlvA_pagL_like; cd05298 991791002263 NAD binding site [chemical binding]; other site 991791002264 sugar binding site [chemical binding]; other site 991791002265 divalent metal binding site [ion binding]; other site 991791002266 putative tetramer (dimer of dimers) interface [polypeptide binding]; other site 991791002267 dimer interface [polypeptide binding]; other site 991791002268 phosphoenolpyruvate synthase; Validated; Region: PRK06241 991791002269 Pyruvate phosphate dikinase, PEP/pyruvate binding domain; Region: PPDK_N; pfam01326 991791002270 PEP-utilising enzyme, mobile domain; Region: PEP-utilizers; pfam00391 991791002271 Metal-dependent hydrolases of the beta-lactamase superfamily II [General function prediction only]; Region: COG1237 991791002272 Short-chain dehydrogenase involved in D-alanine esterification of lipoteichoic acid and wall teichoic acid (D-alanine transfer protein) [Cell envelope biogenesis, outer membrane]; Region: DltE; COG3967 991791002273 classical (c) SDR, subgroup 2; Region: SDR_c2; cd05370 991791002274 putative NAD(P) binding site [chemical binding]; other site 991791002275 active site 991791002276 Endoglucanase E-like members of the SGNH hydrolase family; Endoglucanase E catalyzes the endohydrolysis of 1,4-beta-glucosidic linkages in cellulose, lichenin and cereal beta-D-glucans; Region: Endoglucanase_E_like; cd01831 991791002277 active site 991791002278 catalytic triad [active] 991791002279 oxyanion hole [active] 991791002280 Beta-mannanase [Carbohydrate transport and metabolism]; Region: ManB; COG4124 991791002281 Bacterial surface proteins containing Ig-like domains [Cell motility and secretion]; Region: COG5492 991791002282 Clostridial hydrophobic, with a conserved W residue, domain; Region: ChW; smart00728 991791002283 Clostridial hydrophobic, with a conserved W residue, domain; Region: ChW; smart00728 991791002284 Clostridial hydrophobic, with a conserved W residue, domain; Region: ChW; smart00728 991791002285 Beta-mannanase [Carbohydrate transport and metabolism]; Region: ManB; COG4124 991791002286 Bacterial surface proteins containing Ig-like domains [Cell motility and secretion]; Region: COG5492 991791002287 Clostridial hydrophobic, with a conserved W residue, domain; Region: ChW; smart00728 991791002288 Clostridial hydrophobic, with a conserved W residue, domain; Region: ChW; smart00728 991791002289 Clostridial hydrophobic, with a conserved W residue, domain; Region: ChW; smart00728 991791002290 Beta-mannanase [Carbohydrate transport and metabolism]; Region: ManB; COG4124 991791002291 Bacterial surface proteins containing Ig-like domains [Cell motility and secretion]; Region: COG5492 991791002292 Clostridial hydrophobic, with a conserved W residue, domain; Region: ChW; smart00728 991791002293 Clostridial hydrophobic, with a conserved W residue, domain; Region: ChW; smart00728 991791002294 Clostridial hydrophobic, with a conserved W residue, domain; Region: ChW; smart00728 991791002295 Methyltransferase domain; Region: Methyltransf_31; pfam13847 991791002296 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 991791002297 S-adenosylmethionine binding site [chemical binding]; other site 991791002298 Four helix bundle sensory module for signal transduction; Region: 4HB_MCP_1; pfam12729 991791002299 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 991791002300 dimerization interface [polypeptide binding]; other site 991791002301 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 991791002302 Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer); Region: MA; smart00283 991791002303 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 991791002304 dimer interface [polypeptide binding]; other site 991791002305 putative CheW interface [polypeptide binding]; other site 991791002306 Methyl-accepting chemotaxis protein [Cell motility and secretion / Signal transduction mechanisms]; Region: Tar; COG0840 991791002307 HAMP domain; Region: HAMP; pfam00672 991791002308 dimerization interface [polypeptide binding]; other site 991791002309 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 991791002310 dimer interface [polypeptide binding]; other site 991791002311 putative CheW interface [polypeptide binding]; other site 991791002312 Uncharacterized protein conserved in bacteria (DUF2128); Region: DUF2128; pfam09901 991791002313 This conserved domain belongs to a superfamily including the bleomycin resistance protein, glyoxalase I, and type I ring-cleaving dioxygenases; Region: Glo_EDI_BRP_like_23; cd09011 991791002314 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 991791002315 Predicted Zn peptidase [Amino acid transport and metabolism]; Region: COG2856 991791002316 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 991791002317 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 991791002318 non-specific DNA binding site [nucleotide binding]; other site 991791002319 salt bridge; other site 991791002320 sequence-specific DNA binding site [nucleotide binding]; other site 991791002321 RNA polymerase sigma factor, sigma-70 family; Region: sigma70-ECF; TIGR02937 991791002322 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 991791002323 DNA binding residues [nucleotide binding] 991791002324 Bacterial surface proteins containing Ig-like domains [Cell motility and secretion]; Region: COG5492 991791002325 Bacterial Ig-like domain (group 2); Region: Big_2; cl02708 991791002326 Bacterial surface proteins containing Ig-like domains [Cell motility and secretion]; Region: COG5492 991791002327 Bacterial Ig-like domain (group 2); Region: Big_2; pfam02368 991791002328 Haemolysin XhlA; Region: XhlA; pfam10779 991791002329 Lyc muramidase is an autolytic lysozyme (autolysin) from Clostridium acetobutylicum encoded by the lyc gene. Lyc has a glycosyl hydrolase family 25 (GH25) catalytic domain. Endo-N-acetylmuramidases are lysozymes (also referred to as peptidoglycan...; Region: GH25_Lyc-like; cd06525 991791002330 Glycosyl hydrolases family 25; Region: Glyco_hydro_25; pfam01183 991791002331 active site 991791002332 Putative peptidoglycan-binding domain-containing protein [Cell envelope biogenesis, outer membrane]; Region: COG3409 991791002333 Putative peptidoglycan binding domain; Region: PG_binding_1; pfam01471 991791002334 Putative peptidoglycan binding domain; Region: PG_binding_1; pfam01471 991791002335 Predicted membrane protein [Function unknown]; Region: COG2717 991791002336 Uncharacterized conserved protein [Function unknown]; Region: COG2013 991791002337 Zn-dependent protease with chaperone function [Posttranslational modification, protein turnover, chaperones]; Region: HtpX; COG0501 991791002338 helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347 991791002339 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 991791002340 putative DNA binding site [nucleotide binding]; other site 991791002341 putative Zn2+ binding site [ion binding]; other site 991791002342 Arabinose efflux permease [Carbohydrate transport and metabolism]; Region: AraJ; COG2814 991791002343 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 991791002344 putative substrate translocation pore; other site 991791002345 Carbohydrate binding domain; Region: CBM_4_9; pfam02018 991791002346 N-terminal Early set domain associated with the catalytic domain of cellulase; Region: E_set_Cellulase_N; cd02850 991791002347 Glycosyl hydrolase family 9; Region: Glyco_hydro_9; pfam00759 991791002348 Dockerin type I repeat; Region: Dockerin_1; pfam00404 991791002349 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 991791002350 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 991791002351 active site 991791002352 phosphorylation site [posttranslational modification] 991791002353 intermolecular recognition site; other site 991791002354 dimerization interface [polypeptide binding]; other site 991791002355 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 991791002356 DNA binding site [nucleotide binding] 991791002357 heavy metal sensor kinase; Region: cztS_silS_copS; TIGR01386 991791002358 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 991791002359 dimerization interface [polypeptide binding]; other site 991791002360 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 991791002361 dimer interface [polypeptide binding]; other site 991791002362 phosphorylation site [posttranslational modification] 991791002363 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 991791002364 ATP binding site [chemical binding]; other site 991791002365 Mg2+ binding site [ion binding]; other site 991791002366 G-X-G motif; other site 991791002367 Malate/L-lactate dehydrogenases [Energy production and conversion]; Region: COG2055 991791002368 Methyltransferase domain; Region: Methyltransf_31; pfam13847 991791002369 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 991791002370 S-adenosylmethionine binding site [chemical binding]; other site 991791002371 aspartate-semialdehyde dehydrogenase; Reviewed; Region: PRK08664 991791002372 Semialdehyde dehydrogenase, NAD binding domain; Region: Semialdhyde_dh; smart00859 991791002373 Ribosome-binding factor A; Region: RBFA; cl00542 991791002374 CAT RNA binding domain; Region: CAT_RBD; smart01061 991791002375 transcriptional antiterminator BglG; Provisional; Region: PRK09772 991791002376 PRD domain; Region: PRD; pfam00874 991791002377 PRD domain; Region: PRD; pfam00874 991791002378 Phosphotransferase system IIC components, glucose/maltose/N-acetylglucosamine-specific [Carbohydrate transport and metabolism]; Region: PtsG; COG1263 991791002379 PTS system N-acetyl glucosamine specific transporter subunits IIABC; Provisional; Region: PRK10255 991791002380 PTS_IIB, PTS system, glucose/sucrose specific IIB subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIB_glc; cd00212 991791002381 active site turn [active] 991791002382 phosphorylation site [posttranslational modification] 991791002383 PTS_IIA, PTS system, glucose/sucrose specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIA_glc; cd00210 991791002384 HPr interaction site; other site 991791002385 glycerol kinase (GK) interaction site [polypeptide binding]; other site 991791002386 active site 991791002387 phosphorylation site [posttranslational modification] 991791002388 Predicted transcriptional regulators [Transcription]; Region: COG1695 991791002389 Transcriptional regulator PadR-like family; Region: PadR; pfam03551 991791002390 Predicted membrane protein [Function unknown]; Region: COG4709 991791002391 Uncharacterized conserved protein [Function unknown]; Region: COG3595 991791002392 Domain of unknown function (DUF4098); Region: DUF4098; pfam13345 991791002393 Domain of unknown function (DUF4098); Region: DUF4098; pfam13345 991791002394 Pectate lyase; Region: Pec_lyase_C; cl01593 991791002395 Beta-xylosidase [Carbohydrate transport and metabolism]; Region: XynB; COG3507 991791002396 Glycosyl hydrolase family 43; Region: GH43_ABN_1; cd08998 991791002397 substrate binding site [chemical binding]; other site 991791002398 active site 991791002399 Ricin-type beta-trefoil; Carbohydrate-binding domain formed from presumed gene triplication. The domain is found in a variety of molecules serving diverse functions such as enzymatic activity, inhibitory toxicity and signal transduction. Highly specific...; Region: RICIN; cd00161 991791002400 putative sugar binding sites [chemical binding]; other site 991791002401 Q-X-W motif; other site 991791002402 B12-dependent methionine synthase; Provisional; Region: metH; PRK09490 991791002403 Methionine synthase I (cobalamin-dependent), methyltransferase domain [Amino acid transport and metabolism]; Region: MetH; COG0646 991791002404 MeTr subgroup of pterin binding enzymes. This family includes cobalamin-dependent methyltransferases such as methyltetrahydrofolate, corrinoid iron-sulfur protein methyltransferase (MeTr) and methionine synthase (MetH). Cobalamin-dependent...; Region: MeTr; cd00740 991791002405 substrate binding pocket [chemical binding]; other site 991791002406 B12 binding domain of methionine synthase. This domain binds methylcobalamin, which it uses as an intermediate methyl carrier from methyltetrahydrofolate (CH3H4folate) to homocysteine (Hcy); Region: methionine_synthase_B12_BD; cd02069 991791002407 B12 binding site [chemical binding]; other site 991791002408 cobalt ligand [ion binding]; other site 991791002409 Vitamin B12 dependent methionine synthase, activation domain; Region: Met_synt_B12; pfam02965 991791002410 Putative Ser protein kinase [Signal transduction mechanisms]; Region: PrkA; COG2766 991791002411 AAA ATPase domain; Region: AAA_16; pfam13191 991791002412 PrkA serine protein kinase C-terminal domain; Region: PrkA; pfam06798 991791002413 Von Willebrand factor type A (vWA) domain was originally found in the blood coagulation protein von Willebrand factor (vWF). Typically, the vWA domain is made up of approximately 200 amino acid residues folded into a classic a/b para-rossmann type of...; Region: vWFA; cd00198 991791002414 metal ion-dependent adhesion site (MIDAS); other site 991791002415 Uncharacterized conserved protein [Function unknown]; Region: SpoVR; COG2719 991791002416 SpoVR like protein; Region: SpoVR; pfam04293 991791002417 cobalamin biosynthesis protein; Provisional; Region: cobD; PRK01209 991791002418 Cobalamin biosynthesis protein CbiK, Co2+ chelatase [Coenzyme metabolism]; Region: CbiK; COG4822 991791002419 Anaerobic cobalamin biosynthetic cobalt chelatase (CbiK), N-terminal domain. CbiK is part of the cobalt-early path for cobalamin biosynthesis. It catalyzes the insertion of cobalt into the oxidized form of precorrin-2, factor II (sirohydrochlorin), the...; Region: CbiK_N; cd03412 991791002420 active site 991791002421 C-terminal domain interface [polypeptide binding]; other site 991791002422 Anaerobic cobalamin biosynthetic cobalt chelatase (CbiK), C-terminal domain. CbiK is part of the cobalt-early path for cobalamin biosynthesis. It catalyzes the insertion of cobalt into the oxidized form of precorrin-2, factor II (sirohydrochlorin), the...; Region: CbiK_C; cd03413 991791002423 active site 991791002424 N-terminal domain interface [polypeptide binding]; other site 991791002425 Precorrin-6Y methyltransferase, the cobalamin biosynthesis enzyme CbiE; Region: Precorrin-6Y-methylase; cd11644 991791002426 active site 991791002427 putative homodimer interface [polypeptide binding]; other site 991791002428 SAM binding site [chemical binding]; other site 991791002429 FOG: CheY-like receiver [Signal transduction mechanisms]; Region: CheY; COG0784 991791002430 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 991791002431 active site 991791002432 phosphorylation site [posttranslational modification] 991791002433 intermolecular recognition site; other site 991791002434 dimerization interface [polypeptide binding]; other site 991791002435 Chemotaxis phosphatase CheX; Region: CheX; pfam13690 991791002436 Predicted inhibitor of MCP methylation, homolog of CheC [Cell motility and secretion]; Region: COG1406 991791002437 Chemotaxis phosphatase CheX; Region: CheX; pfam13690 991791002438 flavodoxin; Provisional; Region: PRK05568 991791002439 Uncharacterized flavoproteins [Energy production and conversion]; Region: FpaA; COG0426 991791002440 Protein of unknown function (DUF3793); Region: DUF3793; pfam12672 991791002441 Biotin-(acetyl-CoA carboxylase) ligase [Coenzyme metabolism]; Region: BirA; COG0340 991791002442 Biotin/lipoate A/B protein ligase family; Region: BPL_LplA_LipB; cl14057 991791002443 riboflavin biosynthesis protein RibD; Region: eubact_ribD; TIGR00326 991791002444 Riboflavin-specific deaminase. Riboflavin biosynthesis protein RibD (Diaminohydroxyphosphoribosylaminopyrimidine deaminase) catalyzes the deamination of 2,5-diamino-6-ribosylamino-4(3H)-pyrimidinone 5'-phosphate, which is an intermediate step in the...; Region: Riboflavin_deaminase-reductase; cd01284 991791002445 catalytic motif [active] 991791002446 Zn binding site [ion binding]; other site 991791002447 RibD C-terminal domain; Region: RibD_C; cl17279 991791002448 riboflavin synthase subunit alpha; Provisional; Region: PRK09289 991791002449 Lumazine binding domain; Region: Lum_binding; pfam00677 991791002450 Lumazine binding domain; Region: Lum_binding; pfam00677 991791002451 bifunctional 3,4-dihydroxy-2-butanone 4-phosphate synthase/GTP cyclohydrolase II protein; Provisional; Region: PRK09311 991791002452 3,4-dihydroxy-2-butanone 4-phosphate synthase; Region: DHBP_synthase; pfam00926 991791002453 GTP cyclohydrolase II (RibA). GTP cyclohydrolase II catalyzes the conversion of GTP to 2,5-diamino-6-ribosylamino-4(3H)-pyrimidinone 5' phosphate, formate, pyrophosphate (APy), and GMP in the biosynthetic pathway of riboflavin. Riboflavin is the...; Region: GTP_cyclohydro2; cd00641 991791002454 dimerization interface [polypeptide binding]; other site 991791002455 active site 991791002456 lumazine synthase (6,7-dimethyl-8-ribityllumazine synthase, LS), catalyzes the penultimate step in the biosynthesis of riboflavin (vitamin B2); type-I; Region: Lumazine_synthase-I; cd09209 991791002457 homopentamer interface [polypeptide binding]; other site 991791002458 active site 991791002459 pyridoxal 5'-phosphate synthase, synthase subunit Pdx1; Region: TIGR00343 991791002460 PdxS is a subunit of the pyridoxal 5'-phosphate (PLP) synthase, an important enzyme in deoxyxylulose 5-phosphate (DXP)-independent pathway for de novo biosynthesis of PLP, present in some eubacteria, in archaea, fungi, plants, plasmodia, and some...; Region: pdxS; cd04727 991791002461 active site 991791002462 multimer interface [polypeptide binding]; other site 991791002463 Glutamine Amidotransferase (GATase_I) involved in pyridoxine biosynthesis; Region: GATase1_PB; cd01749 991791002464 imidazole glycerol phosphate synthase subunit HisH; Provisional; Region: hisH; PRK13152 991791002465 predicted active site [active] 991791002466 catalytic triad [active] 991791002467 Bacillus/Clostridium GerA spore germination protein; Region: GerA; pfam03323 991791002468 Spore germination protein; Region: Spore_permease; pfam03845 991791002469 germination protein, Ger(x)C family; Region: spore_ger_x_C; TIGR02887 991791002470 Spore germination B3/ GerAC like, C-terminal; Region: Spore_GerAC; pfam05504 991791002471 Predicted transcriptional regulators [Transcription]; Region: COG1725 991791002472 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 991791002473 DNA-binding site [nucleotide binding]; DNA binding site 991791002474 Predicted membrane protein [General function prediction only]; Region: COG4194 991791002475 Protein of unknown function (DUF1648); Region: DUF1648; pfam07853 991791002476 FtsH Extracellular; Region: FtsH_ext; pfam06480 991791002477 ATP-dependent metalloprotease FtsH; Region: FtsH_fam; TIGR01241 991791002478 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 991791002479 Walker A motif; other site 991791002480 ATP binding site [chemical binding]; other site 991791002481 Walker B motif; other site 991791002482 arginine finger; other site 991791002483 Peptidase family M41; Region: Peptidase_M41; pfam01434 991791002484 Superfamily I DNA and RNA helicases [General function prediction only]; Region: COG3973 991791002485 Part of AAA domain; Region: AAA_19; pfam13245 991791002486 Family description; Region: UvrD_C_2; pfam13538 991791002487 Acyl carrier protein phosphodiesterase [Lipid metabolism]; Region: AcpD; COG1182 991791002488 PAP2_like_3 proteins. PAP2 is a super-family of phosphatases and haloperoxidases. This subgroup, which is specific to bacteria and archaea, lacks functional characterization and may act as a membrane-associated lipid phosphatase; Region: PAP2_like_3; cd03393 991791002489 Membrane-associated phospholipid phosphatase [Lipid metabolism]; Region: PgpB; COG0671 991791002490 active site 991791002491 Predicted Co/Zn/Cd cation transporters [Inorganic ion transport and metabolism]; Region: MMT1; COG0053 991791002492 cation diffusion facilitator family transporter; Region: CDF; TIGR01297 991791002493 Cation efflux family; Region: Cation_efflux; cl00316 991791002494 M18 Peptidase Aspartyl aminopeptidase; Region: M18_DAP; cd05658 991791002495 Aminopeptidase I zinc metalloprotease (M18); Region: Peptidase_M18; pfam02127 991791002496 active site 991791002497 metal binding site [ion binding]; metal-binding site 991791002498 diaminopimelate decarboxylase; Region: lysA; TIGR01048 991791002499 Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzyme Diaminopimelate Decarboxylase; Region: PLPDE_III_DapDC; cd06828 991791002500 active site 991791002501 pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site 991791002502 substrate binding site [chemical binding]; other site 991791002503 catalytic residues [active] 991791002504 dimer interface [polypeptide binding]; other site 991791002505 Putative glucoamylase; Region: Glycoamylase; pfam10091 991791002506 Second GH94N domain of cyclic beta 1-2 glucan synthetase and similar domains; Region: GH94N_ChvB_NdvB_2_like; cd11753 991791002507 Cellobiose phosphorylase [Carbohydrate transport and metabolism]; Region: COG3459 991791002508 First GH94N domain of cyclic beta 1-2 glucan synthetase and similar domains; Region: GH94N_ChvB_NdvB_1_like; cd11756 991791002509 Protein of unknown function, DUF608; Region: DUF608; pfam04685 991791002510 Putative effector of murein hydrolase [Cell envelope biogenesis, outer membrane]; Region: LrgB; COG1346 991791002511 Putative effector of murein hydrolase LrgA [General function prediction only]; Region: COG1380 991791002512 Spore coat protein [Cell envelope biogenesis, outer membrane]; Region: COG5577 991791002513 Spore coat protein [Cell envelope biogenesis, outer membrane]; Region: COG5577 991791002514 Ferritin-like superfamily of diiron-containing four-helix-bundle proteins; Region: Ferritin_like; cl00264 991791002515 dinuclear metal binding motif [ion binding]; other site 991791002516 HEAT repeats; Region: HEAT_2; pfam13646 991791002517 ABC-type nitrate/sulfonate/bicarbonate transport system, permease component [Inorganic ion transport and metabolism]; Region: TauC; COG0600 991791002518 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 991791002519 dimer interface [polypeptide binding]; other site 991791002520 conserved gate region; other site 991791002521 putative PBP binding loops; other site 991791002522 ABC-ATPase subunit interface; other site 991791002523 ABC-type nitrate/sulfonate/bicarbonate transport system, ATPase component [Inorganic ion transport and metabolism]; Region: TauB; COG1116 991791002524 ATP-binding cassette domain of the nitrate and sulfonate transporters; Region: ABC_NrtD_SsuB_transporters; cd03293 991791002525 Walker A/P-loop; other site 991791002526 ATP binding site [chemical binding]; other site 991791002527 Q-loop/lid; other site 991791002528 ABC transporter signature motif; other site 991791002529 Walker B; other site 991791002530 D-loop; other site 991791002531 H-loop/switch region; other site 991791002532 ABC-type nitrate/sulfonate/bicarbonate transport systems, periplasmic components [Inorganic ion transport and metabolism]; Region: TauA; COG0715 991791002533 NMT1-like family; Region: NMT1_2; pfam13379 991791002534 Exopolyphosphatase [Nucleotide transport and metabolism / Inorganic ion transport and metabolism]; Region: GppA; COG0248 991791002535 Ppx/GppA phosphatase family; Region: Ppx-GppA; pfam02541 991791002536 polyphosphate kinase; Provisional; Region: PRK05443 991791002537 Polyphosphate kinase N-terminal domain; Region: PP_kinase_N; pfam13089 991791002538 Polyphosphate kinase middle domain; Region: PP_kinase; pfam02503 991791002539 Catalytic C-terminal domain, first repeat, of Pseudomonas aeruginosa polyphosphate kinase 1 and similar proteins; Region: PLDc_PaPPK1_C1_like; cd09165 991791002540 putative domain interface [polypeptide binding]; other site 991791002541 putative active site [active] 991791002542 catalytic site [active] 991791002543 Catalytic C-terminal domain, second repeat, of Pseudomonas aeruginosa polyphosphate kinase 1 and similar proteins; Region: PLDc_PaPPK1_C2_like; cd09168 991791002544 putative domain interface [polypeptide binding]; other site 991791002545 putative active site [active] 991791002546 catalytic site [active] 991791002547 Predicted protease [Posttranslational modification, protein turnover, chaperones]; Region: COG4934 991791002548 Activation domain of S53 peptidases; Region: Pro-peptidase_S53; cd11377 991791002549 peptidase domain interface [polypeptide binding]; other site 991791002550 Peptidase domain in the S53 family; Region: Peptidases_S53; cd04056 991791002551 active site 991791002552 catalytic triad [active] 991791002553 calcium binding site [ion binding]; other site 991791002554 tryptophanyl-tRNA synthetase II; Reviewed; Region: PRK12282 991791002555 catalytic core domain of tryptophanyl-tRNA synthetase; Region: TrpRS_core; cd00806 991791002556 active site 991791002557 HIGH motif; other site 991791002558 dimer interface [polypeptide binding]; other site 991791002559 KMSKS motif; other site 991791002560 Transcriptional regulators [Transcription]; Region: MarR; COG1846 991791002561 MarR family; Region: MarR_2; pfam12802 991791002562 Mn2+ and Fe2+ transporters of the NRAMP family [Inorganic ion transport and metabolism]; Region: MntH; COG1914 991791002563 Natural resistance-associated macrophage protein; Region: Nramp; pfam01566 991791002564 sugar phosphate phosphatase; Provisional; Region: PRK10513 991791002565 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 991791002566 active site 991791002567 motif I; other site 991791002568 motif II; other site 991791002569 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 991791002570 Peptide chain release factor RF-3 [Translation, ribosomal structure and biogenesis]; Region: PrfC; COG4108 991791002571 Release Factor 3 (RF3) protein involved in the terminal step of translocation in bacteria; Region: RF3; cd04169 991791002572 G1 box; other site 991791002573 putative GEF interaction site [polypeptide binding]; other site 991791002574 GTP/Mg2+ binding site [chemical binding]; other site 991791002575 Switch I region; other site 991791002576 G2 box; other site 991791002577 G3 box; other site 991791002578 Switch II region; other site 991791002579 G4 box; other site 991791002580 G5 box; other site 991791002581 RF3_II: this subfamily represents the domain II of bacterial Release Factor 3 (RF3). Termination of protein synthesis by the ribosome requires two release factor (RF) classes. The class II RF3 is a GTPase that removes class I RFs (RF1 or RF2) from the...; Region: RF3_II; cd03689 991791002582 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 991791002583 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 991791002584 metal binding site [ion binding]; metal-binding site 991791002585 active site 991791002586 I-site; other site 991791002587 EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2). The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948 991791002588 Predicted phosphatase/phosphohexomutase [General function prediction only]; Region: COG0637 991791002589 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 991791002590 motif II; other site 991791002591 PAP2_like proteins, Aur1_like subfamily. Yeast Aur1p or Ipc1p is necessary for the addition of inositol phosphate to ceramide, an essential step in yeast sphingolipid synthesis, and is the target of several antifungal compounds such as aureobasidin; Region: PAP2_Aur1_like; cd03386 991791002592 active site 991791002593 Membrane-associated phospholipid phosphatase [Lipid metabolism]; Region: PgpB; COG0671 991791002594 Predicted membrane protein [Function unknown]; Region: COG4720 991791002595 Probable zinc-binding domain; Region: zf-trcl; pfam13451 991791002596 GAF domain; Region: GAF_3; pfam13492 991791002597 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 991791002598 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 991791002599 metal binding site [ion binding]; metal-binding site 991791002600 active site 991791002601 I-site; other site 991791002602 tyrosyl-tRNA synthetase; Validated; Region: PRK05912 991791002603 catalytic core domain of tyrosinyl-tRNA synthetase; Region: TyrRS_core; cd00805 991791002604 active site 991791002605 HIGH motif; other site 991791002606 dimer interface [polypeptide binding]; other site 991791002607 KMSKS motif; other site 991791002608 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 991791002609 RNA binding surface [nucleotide binding]; other site 991791002610 Uncharacterized homolog of the cytoplasmic domain of flagellar protein FhlB [Function unknown]; Region: COG2257 991791002611 Predicted phosphohydrolase [General function prediction only]; Region: COG1768 991791002612 Calcineurin-like phosphoesterase; Region: Metallophos; pfam00149 991791002613 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG1655 991791002614 Uncharacterized protein conserved in bacteria (DUF2225); Region: DUF2225; pfam09986 991791002615 Nucleotidyltransferase (NT) domain of RelA- and SpoT-like ppGpp synthetases and hydrolases; Region: NT_Rel-Spo_like; cd05399 991791002616 synthetase active site [active] 991791002617 NTP binding site [chemical binding]; other site 991791002618 metal binding site [ion binding]; metal-binding site 991791002619 Spore germination protein; Region: Spore_permease; cl17796 991791002620 Bacillus/Clostridium GerA spore germination protein; Region: GerA; pfam03323 991791002621 germination protein, Ger(x)C family; Region: spore_ger_x_C; TIGR02887 991791002622 Spore germination B3/ GerAC like, C-terminal; Region: Spore_GerAC; pfam05504 991791002623 leucyl-tRNA synthetase; Validated; Region: leuS; PRK00390 991791002624 catalytic core domain of leucyl-tRNA synthetases; Region: LeuRS_core; cd00812 991791002625 HIGH motif; other site 991791002626 Leucyl-tRNA synthetase, Domain 2; Region: tRNA-synt_1_2; pfam13603 991791002627 nucleotidyl transferase superfamily; Region: nt_trans; cl00015 991791002628 active site 991791002629 KMSKS motif; other site 991791002630 Anticodon-binding domain of bacterial and eukaryotic mitochondrial leucyl tRNA synthetases; Region: Anticodon_Ia_Leu_BEm; cd07958 991791002631 tRNA binding surface [nucleotide binding]; other site 991791002632 DnaJ domain or J-domain. DnaJ/Hsp40 (heat shock protein 40) proteins are highly conserved and play crucial roles in protein translation, folding, unfolding, translocation, and degradation. They act primarily by stimulating the ATPase activity of Hsp70s; Region: DnaJ; cd06257 991791002633 DnaJ-class molecular chaperone with C-terminal Zn finger domain [Posttranslational modification, protein turnover, chaperones]; Region: DnaJ; COG0484 991791002634 HSP70 interaction site [polypeptide binding]; other site 991791002635 TPR repeat; Region: TPR_11; pfam13414 991791002636 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cl02429 991791002637 binding surface 991791002638 Adenylyl cyclase (AC) class IV-like, a subgroup of the CYTH-like superfamily; Region: CYTH-like_AC_IV-like; cd07890 991791002639 putative active site [active] 991791002640 putative metal binding residues [ion binding]; other site 991791002641 putative triphosphate binding site [ion binding]; other site 991791002642 signature motif; other site 991791002643 dimer interface [polypeptide binding]; other site 991791002644 37-kD nucleoid-associated bacterial protein; Region: NA37; pfam04245 991791002645 Glycopeptide antibiotics resistance protein [Defense mechanisms]; Region: VanZ; COG4767 991791002646 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 991791002647 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 991791002648 active site 991791002649 phosphorylation site [posttranslational modification] 991791002650 intermolecular recognition site; other site 991791002651 dimerization interface [polypeptide binding]; other site 991791002652 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 991791002653 DNA binding site [nucleotide binding] 991791002654 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 991791002655 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 991791002656 ATP binding site [chemical binding]; other site 991791002657 Mg2+ binding site [ion binding]; other site 991791002658 G-X-G motif; other site 991791002659 Transposase DDE domain; Region: DDE_Tnp_1_6; pfam13751 991791002660 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3666 991791002661 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 991791002662 Arylsulfatase regulator (Fe-S oxidoreductase) [General function prediction only]; Region: AslB; COG0641 991791002663 FeS/SAM binding site; other site 991791002664 radical SAM additional 4Fe4S-binding SPASM domain; Region: rSAM_more_4Fe4S; TIGR04085 991791002665 Predicted Zn-dependent peptidases [General function prediction only]; Region: PqqL; COG0612 991791002666 Insulinase (Peptidase family M16); Region: Peptidase_M16; pfam00675 991791002667 Peptidase M16 inactive domain; Region: Peptidase_M16_C; pfam05193 991791002668 ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132 991791002669 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 991791002670 Walker A/P-loop; other site 991791002671 ATP binding site [chemical binding]; other site 991791002672 Q-loop/lid; other site 991791002673 ABC transporter signature motif; other site 991791002674 Walker B; other site 991791002675 D-loop; other site 991791002676 H-loop/switch region; other site 991791002677 ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653 991791002678 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; pfam01547 991791002679 ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653 991791002680 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; pfam01547 991791002681 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 991791002682 dimer interface [polypeptide binding]; other site 991791002683 conserved gate region; other site 991791002684 ABC-ATPase subunit interface; other site 991791002685 ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395 991791002686 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 991791002687 dimer interface [polypeptide binding]; other site 991791002688 conserved gate region; other site 991791002689 putative PBP binding loops; other site 991791002690 ABC-ATPase subunit interface; other site 991791002691 HlyD family secretion protein; Region: HlyD_2; pfam12700 991791002692 Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533 991791002693 MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704 991791002694 BFD-like [2Fe-2S] binding domain; Region: Fer2_BFD; cl01093 991791002695 Domain of unknown function (DUF4363); Region: DUF4363; pfam14276 991791002696 Predicted membrane protein [Function unknown]; Region: COG2323 991791002697 Threonyl-tRNA synthetase [Translation, ribosomal structure and biogenesis]; Region: ThrS; COG0441 991791002698 Uridine kinase [Nucleotide transport and metabolism]; Region: Udk; COG0572 991791002699 Uridine monophosphate kinase_like (UMPK_like) is a family of proteins highly similar to the uridine monophosphate kinase (UMPK, EC 2.7.1.48), also known as uridine kinase or uridine-cytidine kinase (UCK); Region: UMPK_like; cd02028 991791002700 active site 991791002701 L-serine dehydratase, iron-sulfur-dependent, beta subunit; Region: sda_beta; TIGR00719 991791002702 Serine dehydratase beta chain; Region: SDH_beta; pfam03315 991791002703 C-terminal ACT domain of the L-serine dehydratase (LSD), iron-sulfur-dependent, beta subunit; Region: ACT_LSD; cd04903 991791002704 putative L-serine binding site [chemical binding]; other site 991791002705 L-serine deaminase [Amino acid transport and metabolism]; Region: SdaA; COG1760 991791002706 Serine dehydratase alpha chain; Region: SDH_alpha; pfam03313 991791002707 CDP-alcohol phosphatidyltransferase; Region: CDP-OH_P_transf; pfam01066 991791002708 CDP-diacylglycerol--serine O-phosphatidyltransferase; Region: pssA; TIGR00473 991791002709 Uncharacterized conserved protein [Function unknown]; Region: COG0398 991791002710 SNARE associated Golgi protein; Region: SNARE_assoc; pfam09335 991791002711 FOG: CBS domain [General function prediction only]; Region: COG0517 991791002712 The CBS domain, named after human CBS, is a small domain originally identified in cystathionine beta-synthase and is subsequently found in a wide range of different proteins. CBS domains usually occur in tandem repeats. They associate to form a so-called...; Region: CBS_pair_9; cd04622 991791002713 putative lipid kinase; Reviewed; Region: PRK13059 991791002714 Diacylglycerol kinase catalytic domain; Region: DAGK_cat; pfam00781 991791002715 Nitrogen regulatory protein PII [Amino acid transport and metabolism]; Region: GlnK; COG0347 991791002716 Nitrogen regulatory protein P-II; Region: P-II; smart00938 991791002717 Ammonia permease [Inorganic ion transport and metabolism]; Region: AmtB; COG0004 991791002718 PRC-barrel domain; Region: PRC; pfam05239 991791002719 MgtE intracellular N domain; Region: MgtE_N; smart00924 991791002720 The CBS domain, named after human CBS, is a small domain originally identified in cystathionine beta-synthase and is subsequently found in a wide range of different proteins. CBS domains usually occur in tandem repeats. They associate to form a so-called...; Region: CBS_pair; cd02205 991791002721 FOG: CBS domain [General function prediction only]; Region: COG0517 991791002722 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domain in the magnesium transporter, MgtE. MgtE and its homologs are found in eubacteria, archaebacteria, and eukaryota. Members of this family transport Mg2+ or other...; Region: CBS_pair_Mg_transporter; cd04606 991791002723 Mn2+ and Fe2+ transporters of the NRAMP family [Inorganic ion transport and metabolism]; Region: MntH; COG1914 991791002724 Natural resistance-associated macrophage protein; Region: Nramp; pfam01566 991791002725 spore cortex-lytic enzyme; Region: spore_SleB; TIGR02869 991791002726 Putative peptidoglycan binding domain; Region: PG_binding_1; pfam01471 991791002727 Cell Wall Hydrolase; Region: Hydrolase_2; pfam07486 991791002728 Serine acetyltransferase [Amino acid transport and metabolism]; Region: CysE; COG1045 991791002729 Serine acetyltransferase (SAT): SAT catalyzes the CoA-dependent acetylation of the side chain hydroxyl group of L-serine to form O-acetylserine, as the first step of a two-step biosynthetic pathway in bacteria and plants leading to the formation of...; Region: LbH_SAT; cd03354 991791002730 trimer interface [polypeptide binding]; other site 991791002731 active site 991791002732 substrate binding site [chemical binding]; other site 991791002733 CoA binding site [chemical binding]; other site 991791002734 1-acyl-sn-glycerol-3-phosphate acyltransferase [Lipid metabolism]; Region: PlsC; COG0204 991791002735 Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: AGPAT-like; Region: LPLAT_AGPAT-like; cd07989 991791002736 putative acyl-acceptor binding pocket; other site 991791002737 Predicted EndoIII-related endonuclease [DNA replication, recombination, and repair]; Region: Nth; COG0177 991791002738 endonuclease III; includes endonuclease III (DNA-(apurinic or apyrimidinic site) lyase), alkylbase DNA glycosidases (Alka-family) and other DNA glycosidases; Region: ENDO3c; cd00056 991791002739 minor groove reading motif; other site 991791002740 helix-hairpin-helix signature motif; other site 991791002741 substrate binding pocket [chemical binding]; other site 991791002742 active site 991791002743 Iron-sulfur binding domain of endonuclease III; Region: EndIII_4Fe-2S; cl15304 991791002744 Cellulase M and related proteins [Carbohydrate transport and metabolism]; Region: FrvX; COG1363 991791002745 M42 Peptidase, Endoglucanase-like subfamily; Region: M42_glucanase_like; cd05657 991791002746 putative oligomer interface [polypeptide binding]; other site 991791002747 putative active site [active] 991791002748 metal binding site [ion binding]; metal-binding site 991791002749 Uncharacterized vancomycin resistance protein [Defense mechanisms]; Region: COG2720 991791002750 Putative peptidoglycan binding domain; Region: PG_binding_4; pfam12229 991791002751 VanW like protein; Region: VanW; pfam04294 991791002752 Glucuronate isomerase; Region: UxaC; pfam02614 991791002753 Glucuronate isomerase [Carbohydrate transport and metabolism]; Region: UxaC; COG1904 991791002754 Transcriptional regulators [Transcription]; Region: PurR; COG1609 991791002755 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 991791002756 DNA binding site [nucleotide binding] 991791002757 domain linker motif; other site 991791002758 Ligand binding domain of the LacI tanscriptional regulator family belonging to the type I periplasmic-binding fold protein superfamily; Region: PBP1_LacI_sugar_binding_like; cd06267 991791002759 dimerization interface [polypeptide binding]; other site 991791002760 ligand binding site [chemical binding]; other site 991791002761 Na+/melibiose symporter and related transporters [Carbohydrate transport and metabolism]; Region: MelB; COG2211 991791002762 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 991791002763 putative substrate translocation pore; other site 991791002764 altronate oxidoreductase; Provisional; Region: PRK03643 991791002765 Mannitol dehydrogenase Rossmann domain; Region: Mannitol_dh; pfam01232 991791002766 Mannitol dehydrogenase C-terminal domain; Region: Mannitol_dh_C; pfam08125 991791002767 Domains similar to fish antifreeze type III protein; Region: SAF_AH_GD; cd11613 991791002768 galactarate dehydratase; Region: galactar-dH20; TIGR03248 991791002769 D-galactarate dehydratase / Altronate hydrolase, C terminus; Region: GD_AH_C; pfam04295 991791002770 aldose 1-epimerase superfamily; Region: Aldose_epim; cd01081 991791002771 active site 991791002772 catalytic residues [active] 991791002773 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 991791002774 haloacid dehalogenase-like hydrolase; Region: Hydrolase_3; pfam08282 991791002775 active site 991791002776 motif I; other site 991791002777 motif II; other site 991791002778 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 991791002779 haloacid dehalogenase-like hydrolase; Region: HAD; cl17202 991791002780 spore photoproduct lyase; Region: photo_TT_lyase; TIGR04070 991791002781 DNA repair photolyase [DNA replication, recombination, and repair]; Region: SplB; COG1533 991791002782 Predicted rRNA methylase (SpoU class) [Translation, ribosomal structure and biogenesis]; Region: CspR; COG0219 991791002783 EDD domain protein, DegV family; Region: DegV; TIGR00762 991791002784 Uncharacterized protein, DegV family COG1307; Region: DegV; pfam02645 991791002785 Uncharacterized ABC-type transport system, periplasmic component/surface lipoprotein [General function prediction only]; Region: Med; COG1744 991791002786 Periplasmic binding domain of basic membrane lipoprotein, PnrA, in Treponema pallidum and its homologs from other bacteria and Archaea; Region: PBP1_BmpA_PnrA_like; cd06354 991791002787 ligand binding site [chemical binding]; other site 991791002788 ABC-type uncharacterized transport systems, ATPase components [General function prediction only]; Region: COG3845 991791002789 First domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_I; cd03216 991791002790 Walker A/P-loop; other site 991791002791 ATP binding site [chemical binding]; other site 991791002792 Q-loop/lid; other site 991791002793 ABC transporter signature motif; other site 991791002794 Walker B; other site 991791002795 D-loop; other site 991791002796 H-loop/switch region; other site 991791002797 Second domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_II; cd03215 991791002798 Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653 991791002799 Transmembrane subunit (TM) of Treponema pallidum (Tp) RbsC-1, RbsC-2 and related proteins. This is a functionally uncharacterized subgroup of TMs which belong to a larger group of TMs of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette; Region: TM_PBP1_transp_TpRbsC_like; cd06580 991791002800 TM-ABC transporter signature motif; other site 991791002801 Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653 991791002802 Transmembrane subunit (TM) of Treponema pallidum (Tp) RbsC-1, RbsC-2 and related proteins. This is a functionally uncharacterized subgroup of TMs which belong to a larger group of TMs of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette; Region: TM_PBP1_transp_TpRbsC_like; cd06580 991791002803 TM-ABC transporter signature motif; other site 991791002804 Endoglucanase [Carbohydrate transport and metabolism]; Region: BglC; COG2730 991791002805 Cellulase (glycosyl hydrolase family 5); Region: Cellulase; pfam00150 991791002806 Ricin-type beta-trefoil; Carbohydrate-binding domain formed from presumed gene triplication. The domain is found in a variety of molecules serving diverse functions such as enzymatic activity, inhibitory toxicity and signal transduction. Highly specific...; Region: RICIN; cd00161 991791002807 putative sugar binding sites [chemical binding]; other site 991791002808 Ricin-type beta-trefoil lectin domain; Region: Ricin_B_lectin; pfam00652 991791002809 Q-X-W motif; other site 991791002810 Ricin-type beta-trefoil; Region: RICIN; smart00458 991791002811 Ricin-type beta-trefoil; Carbohydrate-binding domain formed from presumed gene triplication. The domain is found in a variety of molecules serving diverse functions such as enzymatic activity, inhibitory toxicity and signal transduction. Highly specific...; Region: RICIN; cd00161 991791002812 putative sugar binding sites [chemical binding]; other site 991791002813 Q-X-W motif; other site 991791002814 RNA polymerase factor sigma-54; Reviewed; Region: PRK05932 991791002815 Sigma-54 factor, Activator interacting domain (AID); Region: Sigma54_AID; pfam00309 991791002816 Sigma-54 factor, core binding domain; Region: Sigma54_CBD; pfam04963 991791002817 Sigma-54, DNA binding domain; Region: Sigma54_DBD; pfam04552 991791002818 Transcriptional regulator, contains sigma factor-related N-terminal domain [Transcription]; Region: DeoR; COG2390 991791002819 Predicted transcriptional regulator [Transcription]; Region: COG3388 991791002820 Putative sugar-binding domain; Region: Sugar-bind; pfam04198 991791002821 glyceraldehyde-3-phosphate dehydrogenase, type I; Region: GAPDH-I; TIGR01534 991791002822 Glyceraldehyde 3-phosphate dehydrogenase, NAD binding domain; Region: Gp_dh_N; smart00846 991791002823 Glyceraldehyde 3-phosphate dehydrogenase, C-terminal domain; Region: Gp_dh_C; pfam02800 991791002824 Phosphoglycerate kinase; Region: PGK; pfam00162 991791002825 Phosphoglycerate kinase (PGK) is a monomeric enzyme which catalyzes the transfer of the high-energy phosphate group of 1,3-bisphosphoglycerate to ADP, forming ATP and 3-phosphoglycerate. This reaction represents the first of the two substrate-level...; Region: Phosphoglycerate_kinase; cd00318 991791002826 substrate binding site [chemical binding]; other site 991791002827 hinge regions; other site 991791002828 ADP binding site [chemical binding]; other site 991791002829 catalytic site [active] 991791002830 Triosephosphate isomerase (TIM) is a glycolytic enzyme that catalyzes the interconversion of dihydroxyacetone phosphate and D-glyceraldehyde-3-phosphate. The reaction is very efficient and requires neither cofactors nor metal ions. TIM, usually...; Region: TIM; cd00311 991791002831 triosephosphate isomerase; Provisional; Region: PRK14567 991791002832 substrate binding site [chemical binding]; other site 991791002833 dimer interface [polypeptide binding]; other site 991791002834 catalytic triad [active] 991791002835 Phosphoglyceromutase [Carbohydrate transport and metabolism]; Region: GpmI; COG0696 991791002836 phosphoglyceromutase; Provisional; Region: PRK05434 991791002837 enolase; Provisional; Region: eno; PRK00077 991791002838 Enolase: Enolases are homodimeric enzymes that catalyse the reversible dehydration of 2-phospho-D-glycerate to phosphoenolpyruvate as part of the glycolytic and gluconeogenesis pathways. The reaction is facilitated by the presence of metal ions; Region: enolase; cd03313 991791002839 dimer interface [polypeptide binding]; other site 991791002840 metal binding site [ion binding]; metal-binding site 991791002841 substrate binding pocket [chemical binding]; other site 991791002842 Preprotein translocase subunit SecG [Intracellular trafficking and secretion]; Region: SecG; COG1314 991791002843 ribonuclease R; Region: RNase_R; TIGR02063 991791002844 Ribonuclease B OB domain; Region: OB_RNB; pfam08206 991791002845 S1_like: Ribosomal protein S1-like RNA-binding domain. Found in a wide variety of RNA-associated proteins. Originally identified in S1 ribosomal protein. This superfamily also contains the Cold Shock Domain (CSD), which is a homolog of the S1 domain; Region: S1_like; cl09927 991791002846 RNB domain; Region: RNB; pfam00773 991791002847 S1_RNase_R: RNase R C-terminal S1 domain. RNase R is a processive 3' to 5' exoribonuclease, which is a homolog of RNase II. RNase R degrades RNA with secondary structure having a 3' overhang of at least 7 nucleotides. RNase R and PNPase...; Region: S1_RNase_R; cd04471 991791002848 RNA binding site [nucleotide binding]; other site 991791002849 Small protein B (SmpB) is a component of the trans-translation system in prokaryotes for releasing stalled ribosome from damaged messenger RNAs; Region: SmpB; cd09294 991791002850 SmpB-tmRNA interface; other site 991791002851 This group contains class II terpene cyclases, protein prenyltransferases beta subunit, two broadly specific proteinase inhibitors alpha2-macroglobulin (alpha (2)-M) and pregnancy zone protein (PZP) and, the C3 C4 and C5 components of vertebrate...; Region: ISOPREN_C2_like; cl08267 991791002852 This family contains NADPH-dependent flavin reductase and oxygen-insensitive nitroreductase. These enzymes are homodimeric flavoproteins that contain one FMN per monomer as a cofactor. Flavin reductase catalyzes the reduction of flavin by using NADPH as...; Region: NfsA_FRP; cd02146 991791002853 dimer interface [polypeptide binding]; other site 991791002854 FMN binding site [chemical binding]; other site 991791002855 NADPH bind site [chemical binding]; other site 991791002856 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 991791002857 active site 991791002858 Dehydrogenases with different specificities (related to short-chain alcohol dehydrogenases) [Secondary metabolites biosynthesis, transport, and catabolism / General function prediction only]; Region: FabG; COG1028 991791002859 Epoxide hydrolase N terminus; Region: EHN; pfam06441 991791002860 Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596 991791002861 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 991791002862 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 991791002863 Protein of unknown function with HXXEE motif; Region: HXXEE; pfam13787 991791002864 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 991791002865 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 991791002866 probable dihydroxyacetone kinase regulator; Region: DHAK_reg; TIGR02366 991791002867 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 991791002868 Protein of unknown function with HXXEE motif; Region: HXXEE; pfam13787 991791002869 Ribose 5-phosphate isomerase RpiB [Carbohydrate transport and metabolism]; Region: RpiB; COG0698 991791002870 putative transport protein YifK; Provisional; Region: PRK10746 991791002871 Methyltransferase domain; Region: Methyltransf_31; pfam13847 991791002872 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 991791002873 S-adenosylmethionine binding site [chemical binding]; other site 991791002874 Domain of unknown function (DUF4317); Region: DUF4317; pfam14199 991791002875 Predicted permease, member of the PurR regulon [General function prediction only]; Region: yhhT; COG0628 991791002876 Domain of unknown function DUF20; Region: UPF0118; pfam01594 991791002877 Nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: WcaG; COG0451 991791002878 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 991791002879 NAD(P) binding site [chemical binding]; other site 991791002880 active site 991791002881 Domain of unknown function (DUF4118); Region: DUF4118; pfam13493 991791002882 GAF domain; Region: GAF_3; pfam13492 991791002883 Uncharacterized protein conserved in bacteria (DUF2194); Region: DUF2194; pfam09960 991791002884 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4878 991791002885 Putative NodB-like catalytic domain of uncharacterized proteins found in bacteria; Region: CE4_COG4878; cd10924 991791002886 NodB motif; other site 991791002887 putative active site [active] 991791002888 putative catalytic site [active] 991791002889 putative Zn binding site [ion binding]; other site 991791002890 This family is most closely related to the GT1 family of glycosyltransferases. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can...; Region: GT1_like_3; cd03813 991791002891 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 991791002892 Predicted membrane protein [Function unknown]; Region: COG4267 991791002893 Uncharacterized conserved protein [Function unknown]; Region: COG3868 991791002894 glutamate dehydrogenase; Provisional; Region: PRK09414 991791002895 Glu/Leu/Phe/Val dehydrogenase, dimerisation domain; Region: ELFV_dehydrog_N; pfam02812 991791002896 NAD(P) binding domain of glutamate dehydrogenase, subgroup 2; Region: NAD_bind_2_Glu_DH; cd05313 991791002897 NAD(P) binding site [chemical binding]; other site 991791002898 DNA polymerase III subunit epsilon; Validated; Region: PRK06195 991791002899 an uncharacterized bacterial subgroup of the DEDDh 3'-5' exonuclease domain family with similarity to the epsilon subunit of DNA polymerase III; Region: DNA_pol_III_epsilon_like; cd06130 991791002900 active site 991791002901 catalytic site [active] 991791002902 substrate binding site [chemical binding]; other site 991791002903 Breast Cancer Suppressor Protein (BRCA1), carboxy-terminal domain. The BRCT domain is found within many DNA damage repair and cell cycle checkpoint proteins. The unique diversity of this domain superfamily allows BRCT modules to interact forming homo...; Region: BRCT; cd00027 991791002904 Dimer interface [polypeptide binding]; other site 991791002905 BRCT sequence motif; other site 991791002906 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG1550 991791002907 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 991791002908 dimer interface [polypeptide binding]; other site 991791002909 putative CheW interface [polypeptide binding]; other site 991791002910 Membrane-associated phospholipid phosphatase [Lipid metabolism]; Region: PgpB; COG0671 991791002911 PAP2, bacterial acid phosphatase or class A non-specific acid phosphatases. These enzymes catalyze phosphomonoester hydrolysis, with optimal activity in low pH conditions. They are secreted into the periplasmic space, and their physiological role remains...; Region: PAP2_acid_phosphatase; cd03397 991791002912 active site 991791002913 Autotransporter-associated beta strand repeat; Region: Autotrns_rpt; pfam12951 991791002914 Beta-glucosidase/6-phospho-beta-glucosidase/beta- galactosidase [Carbohydrate transport and metabolism]; Region: BglB; COG2723 991791002915 beta-galactosidase; Region: BGL; TIGR03356 991791002916 Na+/H+ antiporter [Energy production and conversion]; Region: NhaC; COG1757 991791002917 Transcriptional regulator [Transcription]; Region: LysR; COG0583 991791002918 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 991791002919 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cd05466 991791002920 dimerization interface [polypeptide binding]; other site 991791002921 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4412 991791002922 Immune inhibitor A peptidase M6; Region: Peptidase_M6; pfam05547 991791002923 Putative peptidoglycan binding domain; Region: PG_binding_4; pfam12229 991791002924 Uncharacterized protein conserved in bacteria [Function unknown]; Region: ErfK; COG1376 991791002925 Putative peptidoglycan binding domain; Region: PG_binding_4; pfam12229 991791002926 L,D-transpeptidase catalytic domain; Region: YkuD; pfam03734 991791002927 Proteins of this family catalyze the reduction of flavin or nitrocompounds using NAD(P)H as electron donor in a obligatory two-electron transfer, utilizing FMN or FAD as cofactor. They are often found to be homodimers. Enzymes of this family are...; Region: Nitro_FMN_reductase; cl00514 991791002928 FMN binding site [chemical binding]; other site 991791002929 dimer interface [polypeptide binding]; other site 991791002930 Predicted HD-superfamily hydrolase [General function prediction only]; Region: COG3481 991791002931 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 991791002932 Zn2+ binding site [ion binding]; other site 991791002933 Mg2+ binding site [ion binding]; other site 991791002934 Dipeptide/tripeptide permease [Amino acid transport and metabolism]; Region: PTR2; COG3104 991791002935 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 991791002936 putative substrate translocation pore; other site 991791002937 RNA ligase; Region: RNA_ligase; pfam09414 991791002938 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 991791002939 Zn2+ binding site [ion binding]; other site 991791002940 Mg2+ binding site [ion binding]; other site 991791002941 AAA domain; Region: AAA_33; pfam13671 991791002942 SseB protein; Region: SseB; cl06279 991791002943 Flavodoxin-like fold; Region: Flavodoxin_2; cl00438 991791002944 Multimeric flavodoxin WrbA [General function prediction only]; Region: WrbA; COG0655 991791002945 Bystin; Region: Bystin; pfam05291 991791002946 Tim44 is an essential component of the machinery that mediates the translocation of nuclear-encoded proteins across the mitochondrial inner membrane; Region: Tim44; smart00978 991791002947 hybrid cluster protein-associated redox disulfide domain; Region: prismane_assoc; TIGR03980 991791002948 Hemerythrin-like domain; Region: Hr-like; cd12108 991791002949 Fe binding site [ion binding]; other site 991791002950 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 991791002951 Major Facilitator Superfamily; Region: MFS_1; pfam07690 991791002952 putative substrate translocation pore; other site 991791002953 helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347 991791002954 MarR family; Region: MarR; pfam01047 991791002955 dihydropyrimidine dehydrogenase subunit A; Provisional; Region: PRK11749 991791002956 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500 991791002957 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 991791002958 Predicted oxidoreductases of the aldo/keto reductase family [General function prediction only]; Region: COG1453 991791002959 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 991791002960 active site 991791002961 catalytic tetrad [active] 991791002962 The HCP family of iron-sulfur proteins includes hybrid cluster protein (HCP), acetyl-CoA synthase (ACS), and carbon monoxide dehydrogenase (CODH), all of which contain [Fe4-S4] metal clusters at their active sites. These proteins have a conserved...; Region: HCP_like; cl14655 991791002963 Predicted transcriptional regulators [Transcription]; Region: SoxR; COG0789 991791002964 Helix-Turn-Helix DNA binding domain of the MerR-like transcription regulators YyaN and YraB; Region: HTH_YyaN; cd01109 991791002965 DNA binding residues [nucleotide binding] 991791002966 putative dimer interface [polypeptide binding]; other site 991791002967 Predicted oxidoreductases of the aldo/keto reductase family [General function prediction only]; Region: COG1453 991791002968 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 991791002969 active site 991791002970 catalytic tetrad [active] 991791002971 The HCP family of iron-sulfur proteins includes hybrid cluster protein (HCP), acetyl-CoA synthase (ACS), and carbon monoxide dehydrogenase (CODH), all of which contain [Fe4-S4] metal clusters at their active sites. These proteins have a conserved...; Region: HCP_like; cl14655 991791002972 Transcriptional regulator [Transcription]; Region: LysR; COG0583 991791002973 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 991791002974 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cd05466 991791002975 dimerization interface [polypeptide binding]; other site 991791002976 Uncharacterized conserved protein [Function unknown]; Region: COG3875 991791002977 Major intrinsic protein (MIP) superfamily. Members of the MIP superfamily function as membrane channels that selectively transport water, small neutral molecules, and ions out of and between cells. The channel proteins share a common fold: the N-terminal...; Region: MIP; cd00333 991791002978 amphipathic channel; other site 991791002979 Asn-Pro-Ala signature motifs; other site 991791002980 cobalt transport protein CbiM; Provisional; Region: PRK07331 991791002981 cobalt transport protein CbiM; Provisional; Region: PRK11909 991791002982 ABC-type cobalt transport system, permease component CbiQ and related transporters [Inorganic ion transport and metabolism]; Region: CbiQ; COG0619 991791002983 ABC-type cobalt transport system, ATPase component [Inorganic ion transport and metabolism]; Region: CbiO; COG1122 991791002984 First domain of the ATP-binding cassette component of cobalt transport system; Region: ABC_cobalt_CbiO_domain1; cd03225 991791002985 Walker A/P-loop; other site 991791002986 ATP binding site [chemical binding]; other site 991791002987 Q-loop/lid; other site 991791002988 ABC transporter signature motif; other site 991791002989 Walker B; other site 991791002990 D-loop; other site 991791002991 H-loop/switch region; other site 991791002992 hypothetical protein; Provisional; Region: PRK04194 991791002993 ATP-utilizing enzymes of the PP-loop superfamily [General function prediction only]; Region: COG1606 991791002994 This is a subfamily of Adenine nucleotide alpha hydrolases superfamily. Adenine nucleotide alpha hydrolases superfamily includes N type ATP PPases and ATP sulphurylases. It forms a apha/beta/apha fold which binds to Adenosine group. This subfamily; Region: Alpha_ANH_like_I; cd01990 991791002995 Ligand Binding Site [chemical binding]; other site 991791002996 NCAIR mutase (PurE)-related proteins [General function prediction only]; Region: COG1691 991791002997 AIR carboxylase; Region: AIRC; smart01001 991791002998 Acetyltransferase (isoleucine patch superfamily) [General function prediction only]; Region: WbbJ; COG0110 991791002999 Xenobiotic acyltransferase (XAT): The XAT class of hexapeptide acyltransferases is composed of a large number of microbial enzymes that catalyze the CoA-dependent acetylation of a variety of hydroxyl-bearing acceptors such as chloramphenicol and...; Region: LbH_XAT; cd03349 991791003000 trimer interface [polypeptide binding]; other site 991791003001 active site 991791003002 substrate binding site [chemical binding]; other site 991791003003 CoA binding site [chemical binding]; other site 991791003004 Superfamily II DNA and RNA helicases [DNA replication, recombination, and repair / Transcription / Translation, ribosomal structure and biogenesis]; Region: SrmB; COG0513 991791003005 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 991791003006 ATP binding site [chemical binding]; other site 991791003007 putative Mg++ binding site [ion binding]; other site 991791003008 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 991791003009 nucleotide binding region [chemical binding]; other site 991791003010 ATP-binding site [chemical binding]; other site 991791003011 Mitochondrial degradasome RNA helicase subunit C terminal; Region: SUV3_C; pfam12513 991791003012 Isochorismatase family; Region: Isochorismatase; pfam00857 991791003013 Cysteine hydrolases; This family contains amidohydrolases, like CSHase (N-carbamoylsarcosine amidohydrolase), involved in creatine metabolism and nicotinamidase, converting nicotinamide to nicotinic acid and ammonia in the pyridine nucleotide cycle. It...; Region: cysteine_hydrolases; cd00431 991791003014 catalytic triad [active] 991791003015 conserved cis-peptide bond; other site 991791003016 tyrosyl-tRNA synthetase; Provisional; Region: PRK13354 991791003017 catalytic core domain of tyrosinyl-tRNA synthetase; Region: TyrRS_core; cd00805 991791003018 active site 991791003019 HIGH motif; other site 991791003020 dimer interface [polypeptide binding]; other site 991791003021 KMSKS motif; other site 991791003022 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 991791003023 RNA binding surface [nucleotide binding]; other site 991791003024 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4296 991791003025 Pentapeptide repeats (9 copies); Region: Pentapeptide_4; pfam13599 991791003026 Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805 991791003027 DEAD-box helicases. A diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker B motif; Region: DEADc; cd00268 991791003028 DEAD-like helicases superfamily; Region: DEXDc; smart00487 991791003029 ATP binding site [chemical binding]; other site 991791003030 Mg++ binding site [ion binding]; other site 991791003031 motif III; other site 991791003032 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 991791003033 nucleotide binding region [chemical binding]; other site 991791003034 ATP-binding site [chemical binding]; other site 991791003035 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3861 991791003036 conserved domain; Region: TIGR02271 991791003037 iron-hydroxamate transporter permease subunit; Provisional; Region: PRK10577 991791003038 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550 991791003039 ABC-ATPase subunit interface; other site 991791003040 dimer interface [polypeptide binding]; other site 991791003041 putative PBP binding regions; other site 991791003042 iron-hydroxamate transporter permease subunit; Provisional; Region: PRK10577 991791003043 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550 991791003044 ABC-ATPase subunit interface; other site 991791003045 dimer interface [polypeptide binding]; other site 991791003046 putative PBP binding regions; other site 991791003047 ABC-type Fe3+-hydroxamate transport system, periplasmic component [Inorganic ion transport and metabolism]; Region: FepB; COG0614 991791003048 Periplasmic binding protein FeuA. These proteins have predicted to function as initial receptors in ABC transport of metal ions in some eubacterial species. They belong to the TroA superfamily of periplasmic metal binding proteins that share a distinct...; Region: FeuA; cd01138 991791003049 putative ligand binding residues [chemical binding]; other site 991791003050 ABC-type cobalamin/Fe3+-siderophores transport systems, ATPase components [Inorganic ion transport and metabolism / Coenzyme metabolism]; Region: FepC; COG1120 991791003051 ATP-binding component of iron-siderophores, vitamin B12 and hemin transporters and related proteins; Region: ABC_Iron-Siderophores_B12_Hemin; cd03214 991791003052 Walker A/P-loop; other site 991791003053 ATP binding site [chemical binding]; other site 991791003054 Q-loop/lid; other site 991791003055 ABC transporter signature motif; other site 991791003056 Walker B; other site 991791003057 D-loop; other site 991791003058 H-loop/switch region; other site 991791003059 Branched-chain amino acid aminotransferase/4-amino-4-deoxychorismate lyase [Amino acid transport and metabolism / Coenzyme metabolism]; Region: IlvE; COG0115 991791003060 D-Alanine aminotransferase (D-AAT_like): D-amino acid aminotransferase catalyzes transamination between D-amino acids and their respective alpha-keto acids. It plays a major role in the synthesis of bacterial cell wall components like D-alanine and...; Region: D-AAT_like; cd01558 991791003061 homodimer interface [polypeptide binding]; other site 991791003062 substrate-cofactor binding pocket; other site 991791003063 pyridoxal 5'-phosphate binding site [chemical binding]; other site 991791003064 catalytic residue [active] 991791003065 Plant protein of unknown function (DUF946); Region: DUF946; pfam06101 991791003066 Nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: WcaG; COG0451 991791003067 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 991791003068 NAD(P) binding site [chemical binding]; other site 991791003069 active site 991791003070 Glycosyltransferases involved in cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WcaA; COG0463 991791003071 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cd00761 991791003072 active site 991791003073 CDP-diglyceride synthetase [Lipid metabolism]; Region: CdsA; COG0575 991791003074 Putative integral membrane protein DUF46; Region: DUF46; cl17511 991791003075 Phosphoenolpyruvate synthase/pyruvate phosphate dikinase [Carbohydrate transport and metabolism]; Region: PpsA; COG0574 991791003076 Pyruvate phosphate dikinase, PEP/pyruvate binding domain; Region: PPDK_N; pfam01326 991791003077 PEP-utilising enzyme, mobile domain; Region: PEP-utilizers; pfam00391 991791003078 CDP-alcohol phosphatidyltransferase; Region: CDP-OH_P_transf; pfam01066 991791003079 CDP-diacylglycerol--serine O-phosphatidyltransferase; Region: pssA; TIGR00473 991791003080 Phosphatidylserine decarboxylase; Region: PS_Dcarbxylase; cl03656 991791003081 prenyltransferase; Provisional; Region: ubiA; PRK13592 991791003082 UbiA prenyltransferase family; Region: UbiA; pfam01040 991791003083 phosphoenolpyruvate synthase; Validated; Region: PRK06241 991791003084 Pyruvate phosphate dikinase, PEP/pyruvate binding domain; Region: PPDK_N; pfam01326 991791003085 PEP-utilising enzyme, mobile domain; Region: PEP-utilizers; pfam00391 991791003086 Pectate lyase [Carbohydrate transport and metabolism]; Region: PelB; COG3866 991791003087 Pectate lyase; Region: Pec_lyase_C; cl01593 991791003088 ligand binding domain of Tar- and Tsr-related chemoreceptors; Region: Tar_Tsr_LBD; cl00144 991791003089 Cache domain; Region: Cache_1; pfam02743 991791003090 Methyl-accepting chemotaxis protein [Cell motility and secretion / Signal transduction mechanisms]; Region: Tar; COG0840 991791003091 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 991791003092 dimerization interface [polypeptide binding]; other site 991791003093 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 991791003094 dimer interface [polypeptide binding]; other site 991791003095 putative CheW interface [polypeptide binding]; other site 991791003096 Cold-Shock Protein (CSP) contains an S1-like cold-shock domain (CSD) that is found in eukaryotes, prokaryotes, and archaea. CSP's include the major cold-shock proteins CspA and CspB in bacteria and the eukaryotic gene regulatory factor Y-box...; Region: CSP_CDS; cd04458 991791003097 DNA-binding site [nucleotide binding]; DNA binding site 991791003098 RNA-binding motif; other site 991791003099 Hydrogenase maturation factor [Posttranslational modification, protein turnover, chaperones]; Region: HypC; COG0298 991791003100 HypE (Hydrogenase expression/formation protein). HypE is involved in Ni-Fe hydrogenase biosynthesis. HypE dehydrates its own carbamoyl moiety in an ATP-dependent process to yield the enzyme thiocyanate. The N-terminal domain of HypE is related to the...; Region: HypE; cd02197 991791003101 dimerization interface [polypeptide binding]; other site 991791003102 hydrogenase expression/formation protein HypE; Region: hypE; TIGR02124 991791003103 ATP binding site [chemical binding]; other site 991791003104 Acylphosphatase; Region: Acylphosphatase; pfam00708 991791003105 Hydrogenase maturation factor [Posttranslational modification, protein turnover, chaperones]; Region: HypF; COG0068 991791003106 HypF finger; Region: zf-HYPF; pfam07503 991791003107 HypF finger; Region: zf-HYPF; pfam07503 991791003108 Telomere recombination; Region: Sua5_yciO_yrdC; pfam01300 991791003109 hydrogenase isoenzymes formation protein HypD; Provisional; Region: PRK15062 991791003110 hydrogenase expression/formation protein HypD; Region: hypD; TIGR00075 991791003111 Zinc dependent phospholipase C; Region: Zn_dep_PLPC; pfam00882 991791003112 3-oxoacyl-[acyl-carrier-protein]; Region: FabH; COG0332 991791003113 Ketoacyl-acyl carrier protein synthase III (KASIII) initiates the elongation in type II fatty acid synthase systems. It is found in bacteria and plants. Elongation of fatty acids in the type II systems occurs by Claisen condensation of malonyl-acyl...; Region: KAS_III; cd00830 991791003114 dimer interface [polypeptide binding]; other site 991791003115 active site 991791003116 CoA binding pocket [chemical binding]; other site 991791003117 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 991791003118 dimer interface [polypeptide binding]; other site 991791003119 putative CheW interface [polypeptide binding]; other site 991791003120 Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596 991791003121 BAAT / Acyl-CoA thioester hydrolase C terminal; Region: BAAT_C; pfam08840 991791003122 7TM diverse intracellular signalling; Region: 7TMR-DISM_7TM; pfam07695 991791003123 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 991791003124 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 991791003125 metal binding site [ion binding]; metal-binding site 991791003126 active site 991791003127 I-site; other site 991791003128 phosphoribosylpyrophosphate synthetase; Provisional; Region: PRK06827 991791003129 N-terminal domain of ribose phosphate pyrophosphokinase; Region: Pribosyltran_N; pfam13793 991791003130 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 991791003131 active site 991791003132 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3878 991791003133 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 991791003134 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 991791003135 ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136 991791003136 ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255 991791003137 Walker A/P-loop; other site 991791003138 ATP binding site [chemical binding]; other site 991791003139 Q-loop/lid; other site 991791003140 ABC transporter signature motif; other site 991791003141 Walker B; other site 991791003142 D-loop; other site 991791003143 H-loop/switch region; other site 991791003144 MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704 991791003145 FtsX-like permease family; Region: FtsX; pfam02687 991791003146 ABC-type transport system, involved in lipoprotein release, permease component [Cell envelope biogenesis, outer membrane]; Region: LolE; COG4591 991791003147 MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704 991791003148 FtsX-like permease family; Region: FtsX; pfam02687 991791003149 TRX family; composed of two groups: Group I, which includes proteins that exclusively encode a TRX domain; and Group II, which are composed of fusion proteins of TRX and additional domains. Group I TRX is a small ancient protein that alter the redox...; Region: TRX_family; cd02947 991791003150 catalytic residues [active] 991791003151 Endoglucanase [Carbohydrate transport and metabolism]; Region: BglC; COG2730 991791003152 Cellulase (glycosyl hydrolase family 5); Region: Cellulase; pfam00150 991791003153 Endoglucanase [Carbohydrate transport and metabolism]; Region: BglC; COG2730 991791003154 Cellulase (glycosyl hydrolase family 5); Region: Cellulase; pfam00150 991791003155 Tagatose-1,6-bisphosphate (TBP) aldolase and related Type B Class II aldolases. TBP aldolase is a tetrameric class II aldolase that catalyzes the reversible condensation of dihydroxyacetone phosphate with glyceraldehyde 3-phsophate to produce tagatose 1; Region: TBP_aldolase_IIB; cd00947 991791003156 fructose-bisphosphate aldolase; Provisional; Region: PRK09197 991791003157 intersubunit interface [polypeptide binding]; other site 991791003158 active site 991791003159 zinc binding site [ion binding]; other site 991791003160 Na+ binding site [ion binding]; other site 991791003161 Glycopeptide antibiotics resistance protein [Defense mechanisms]; Region: VanZ; COG4767 991791003162 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 991791003163 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 991791003164 active site 991791003165 phosphorylation site [posttranslational modification] 991791003166 intermolecular recognition site; other site 991791003167 dimerization interface [polypeptide binding]; other site 991791003168 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 991791003169 DNA binding site [nucleotide binding] 991791003170 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 991791003171 dimerization interface [polypeptide binding]; other site 991791003172 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 991791003173 dimer interface [polypeptide binding]; other site 991791003174 phosphorylation site [posttranslational modification] 991791003175 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 991791003176 ATP binding site [chemical binding]; other site 991791003177 Mg2+ binding site [ion binding]; other site 991791003178 G-X-G motif; other site 991791003179 Predicted transcriptional regulators [Transcription]; Region: COG1695 991791003180 Transcriptional regulator PadR-like family; Region: PadR; pfam03551 991791003181 ABC-type Na+ transport system, ATPase component [Energy production and conversion / Inorganic ion transport and metabolism]; Region: NatA; COG4555 991791003182 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 991791003183 Walker A/P-loop; other site 991791003184 ATP binding site [chemical binding]; other site 991791003185 Q-loop/lid; other site 991791003186 ABC transporter signature motif; other site 991791003187 Walker B; other site 991791003188 D-loop; other site 991791003189 H-loop/switch region; other site 991791003190 ABC-type multidrug transport system, permease component [Defense mechanisms]; Region: COG0842 991791003191 ABC-2 type transporter; Region: ABC2_membrane; cl17235 991791003192 ABC-type multidrug transport system, permease component [Defense mechanisms]; Region: COG0842 991791003193 ABC-2 type transporter; Region: ABC2_membrane; pfam01061 991791003194 Domain of unknown function (DUF386); Region: DUF386; pfam04074 991791003195 Spermidine/putrescine-binding periplasmic protein [Amino acid transport and metabolism]; Region: PotD; COG0687 991791003196 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; cl17199 991791003197 ABC-type spermidine/putrescine transport system, permease component II [Amino acid transport and metabolism]; Region: PotC; COG1177 991791003198 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 991791003199 dimer interface [polypeptide binding]; other site 991791003200 putative PBP binding loops; other site 991791003201 ABC-ATPase subunit interface; other site 991791003202 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 991791003203 dimer interface [polypeptide binding]; other site 991791003204 conserved gate region; other site 991791003205 putative PBP binding loops; other site 991791003206 ABC-ATPase subunit interface; other site 991791003207 ABC-type spermidine/putrescine transport systems, ATPase components [Amino acid transport and metabolism]; Region: PotA; COG3842 991791003208 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 991791003209 Walker A/P-loop; other site 991791003210 ATP binding site [chemical binding]; other site 991791003211 Q-loop/lid; other site 991791003212 ABC transporter signature motif; other site 991791003213 Walker B; other site 991791003214 D-loop; other site 991791003215 H-loop/switch region; other site 991791003216 TOBE domain; Region: TOBE_2; pfam08402 991791003217 DNA-binding transcriptional repressor PuuR; Provisional; Region: PRK09943 991791003218 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 991791003219 non-specific DNA binding site [nucleotide binding]; other site 991791003220 salt bridge; other site 991791003221 sequence-specific DNA binding site [nucleotide binding]; other site 991791003222 Cupin domain; Region: Cupin_2; pfam07883 991791003223 Barnase, a member of the family of homologous microbial ribonucleases, catalyses the cleavage of single-stranded RNA via a two-step mechanism thought to be similar to that of pancreatic ribonuclease. The mechanism involves a transesterification to give a...; Region: barnase; cd00933 991791003224 active site 991791003225 Barstar is an intracellular inhibitor of barnase, an extracellular ribonuclease of Bacillus amyloliquefaciens. Barstar binds tightly to the barnase active site and sterically blocks it thus inhibiting its potentially lethal RNase activity inside the cell; Region: Barstar; cd05142 991791003226 RNAase interaction site [polypeptide binding]; other site 991791003227 nonheme-containing ferritins; Region: Nonheme_Ferritin; cd01055 991791003228 Ferritin-like domain; Region: Ferritin; pfam00210 991791003229 ferroxidase diiron center [ion binding]; other site 991791003230 Na+-driven multidrug efflux pump [Defense mechanisms]; Region: NorM; COG0534 991791003231 Uncharacterized subfamily of the multidrug and toxic compound extrusion (MATE) proteins; Region: MATE_like_8; cd13134 991791003232 Uncharacterized conserved protein [Function unknown]; Region: COG1284 991791003233 Uncharacterized BCR, YitT family COG1284; Region: DUF161; pfam02588 991791003234 Uncharacterized BCR, YitT family COG1284; Region: DUF161; pfam02588 991791003235 Uncharacterized protein conserved in bacteria (DUF2179); Region: DUF2179; pfam10035 991791003236 Predicted transcriptional regulators [Transcription]; Region: COG1733 991791003237 HxlR-like helix-turn-helix; Region: HxlR; pfam01638 991791003238 Nitroreductase-like family 1. A subfamily of the nitroreductase family containing uncharacterized proteins that are similar to nitroreductase. Nitroreductase catalyzes the reduction of nitroaromatic compounds such as nitrotoluenes, nitrofurans and...; Region: Nitroreductase_1; cd02137 991791003239 dimer interface [polypeptide binding]; other site 991791003240 FMN binding site [chemical binding]; other site 991791003241 The Class III extradiol dioxygenase, 4,5-DOPA Dioxygenase, catalyzes the incorporation of both atoms of molecular oxygen into 4,5-dihydroxy-phenylalanine; Region: 45_DOPA_Dioxygenase; cd07363 991791003242 Catalytic LigB subunit of aromatic ring-opening dioxygenase; Region: LigB; pfam02900 991791003243 putative active site [active] 991791003244 metal binding site [ion binding]; metal-binding site 991791003245 Amino acid transporters [Amino acid transport and metabolism]; Region: PotE; COG0531 991791003246 c-di-GMP phosphodiesterase class II (HD-GYP domain) [Signal transduction mechanisms]; Region: COG2206 991791003247 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 991791003248 Zn2+ binding site [ion binding]; other site 991791003249 Mg2+ binding site [ion binding]; other site 991791003250 Translation elongation factors (GTPases) [Translation, ribosomal structure and biogenesis]; Region: FusA; COG0480 991791003251 Tet(M)-like family includes Tet(M), Tet(O), Tet(W), and OtrA, containing tetracycline resistant proteins; Region: TetM_like; cd04168 991791003252 G1 box; other site 991791003253 putative GEF interaction site [polypeptide binding]; other site 991791003254 GTP/Mg2+ binding site [chemical binding]; other site 991791003255 Switch I region; other site 991791003256 G2 box; other site 991791003257 G3 box; other site 991791003258 Switch II region; other site 991791003259 G4 box; other site 991791003260 G5 box; other site 991791003261 Tet_II: This subfamily represents domain II of ribosomal protection proteins Tet(M) and Tet(O). This domain has homology to domain II of the elongation factors EF-G and EF-2. Tet(M) and Tet(O) catalyze the release of tetracycline (Tc) from the ribosome...; Region: Tet_II; cd03690 991791003262 Elongation Factor G-like domain IV. This family includes the translational elongation factor termed EF-2 (for Archaea and Eukarya) and EF-G (for Bacteria), ribosomal protection proteins that mediate tetracycline resistance and, an evolutionarily...; Region: EFG_like_IV; cl02789 991791003263 Tet_C: C-terminus of ribosomal protection proteins Tet(M) and Tet(O). This domain has homology to the C terminal domains of the elongation factors EF-G and EF-2. Tet(M) and Tet(O) catalyze the release of tetracycline (Tc) from the ribosome in a...; Region: Tet_C; cd03711 991791003264 Predicted phosphatase/phosphohexomutase [General function prediction only]; Region: COG0637 991791003265 haloacid dehalogenase-like hydrolase; Region: HAD; cl17202 991791003266 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 991791003267 motif II; other site 991791003268 Transcriptional regulators [Transcription]; Region: PurR; COG1609 991791003269 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 991791003270 DNA binding site [nucleotide binding] 991791003271 domain linker motif; other site 991791003272 Ligand-binding domain of uncharacterized transcription regulator ycjW which is a member of the LacI-GalR family repressors; Region: PBP1_ycjW_transcription_regulator_like; cd06294 991791003273 putative dimerization interface [polypeptide binding]; other site 991791003274 putative ligand binding site [chemical binding]; other site 991791003275 Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013 991791003276 alpha-glucan phosphorylases; Region: more_P_ylases; TIGR02094 991791003277 Sortase and related acyltransferases [Cell envelope biogenesis, outer membrane]; Region: COG1247 991791003278 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 991791003279 Coenzyme A binding pocket [chemical binding]; other site 991791003280 Domain of unknown function (DUF4163); Region: DUF4163; pfam13739 991791003281 Protein of unknown function (DUF3298); Region: DUF3298; pfam11738 991791003282 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 991791003283 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 991791003284 active site 991791003285 phosphorylation site [posttranslational modification] 991791003286 intermolecular recognition site; other site 991791003287 dimerization interface [polypeptide binding]; other site 991791003288 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 991791003289 DNA binding site [nucleotide binding] 991791003290 ABC-type multidrug transport system, ATPase component [Defense mechanisms]; Region: CcmA; COG1131 991791003291 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 991791003292 Walker A/P-loop; other site 991791003293 ATP binding site [chemical binding]; other site 991791003294 Q-loop/lid; other site 991791003295 ABC transporter signature motif; other site 991791003296 Walker B; other site 991791003297 D-loop; other site 991791003298 H-loop/switch region; other site 991791003299 ABC-type transport system involved in multi-copper enzyme maturation, permease component [General function prediction only]; Region: NosY; COG1277 991791003300 ABC-2 family transporter protein; Region: ABC2_membrane_4; pfam12730 991791003301 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 991791003302 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 991791003303 dimer interface [polypeptide binding]; other site 991791003304 phosphorylation site [posttranslational modification] 991791003305 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 991791003306 ATP binding site [chemical binding]; other site 991791003307 Mg2+ binding site [ion binding]; other site 991791003308 G-X-G motif; other site 991791003309 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: COG4585 991791003310 Thylakoid formation protein; Region: ThylakoidFormat; cl12138 991791003311 Histidine kinase; Region: HisKA_3; pfam07730 991791003312 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 991791003313 ATP binding site [chemical binding]; other site 991791003314 Mg2+ binding site [ion binding]; other site 991791003315 G-X-G motif; other site 991791003316 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 991791003317 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 991791003318 active site 991791003319 phosphorylation site [posttranslational modification] 991791003320 intermolecular recognition site; other site 991791003321 dimerization interface [polypeptide binding]; other site 991791003322 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 991791003323 DNA binding residues [nucleotide binding] 991791003324 dimerization interface [polypeptide binding]; other site 991791003325 ABC-type multidrug transport system, ATPase component [Defense mechanisms]; Region: CcmA; COG1131 991791003326 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 991791003327 Walker A/P-loop; other site 991791003328 ATP binding site [chemical binding]; other site 991791003329 Q-loop/lid; other site 991791003330 ABC transporter signature motif; other site 991791003331 Walker B; other site 991791003332 D-loop; other site 991791003333 H-loop/switch region; other site 991791003334 ABC-2 family transporter protein; Region: ABC2_membrane_3; pfam12698 991791003335 YhgE/Pip N-terminal domain; Region: pip_yhgE_Nterm; TIGR03061 991791003336 thioredoxin-disulfide reductase; Region: TRX_reduct; TIGR01292 991791003337 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox_3; pfam13738 991791003338 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 991791003339 xanthine permease; Region: pbuX; TIGR03173 991791003340 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 991791003341 active site 991791003342 EamA-like transporter family; Region: EamA; pfam00892 991791003343 Carboxylate/Amino Acid/Amine Transporter; Region: 2A78; TIGR00950 991791003344 EamA-like transporter family; Region: EamA; pfam00892 991791003345 helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347 991791003346 MarR family; Region: MarR; pfam01047 991791003347 Cyclopropane fatty acid synthase and related methyltransferases [Cell envelope biogenesis, outer membrane]; Region: Cfa; COG2230 991791003348 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 991791003349 S-adenosylmethionine binding site [chemical binding]; other site 991791003350 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 991791003351 ABC-type arginine transport system, permease component [Amino acid transport and metabolism]; Region: ArtQ; COG4215 991791003352 dimer interface [polypeptide binding]; other site 991791003353 conserved gate region; other site 991791003354 putative PBP binding loops; other site 991791003355 ABC-ATPase subunit interface; other site 991791003356 ABC-type polar amino acid transport system, ATPase component [Amino acid transport and metabolism]; Region: GlnQ; COG1126 991791003357 ATP-binding cassette domain of the histidine and glutamine transporters; Region: ABC_HisP_GlnQ; cd03262 991791003358 Walker A/P-loop; other site 991791003359 ATP binding site [chemical binding]; other site 991791003360 Q-loop/lid; other site 991791003361 ABC transporter signature motif; other site 991791003362 Walker B; other site 991791003363 D-loop; other site 991791003364 H-loop/switch region; other site 991791003365 Bacterial extracellular solute-binding proteins, family 3; Region: SBP_bac_3; pfam00497 991791003366 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 991791003367 substrate binding pocket [chemical binding]; other site 991791003368 membrane-bound complex binding site; other site 991791003369 hinge residues; other site 991791003370 Domain of unknown function (DUF1836); Region: DUF1836; pfam08876 991791003371 Predicted membrane protein, hemolysin III homolog [General function prediction only]; Region: COG1272 991791003372 channel protein, hemolysin III family; Region: hlyIII; TIGR01065 991791003373 Subfamily of the multidrug and toxic compound extrusion (MATE)-like proteins similar to Streptococcus aureus MepA; Region: MATE_MepA_like; cd13143 991791003374 Na+-driven multidrug efflux pump [Defense mechanisms]; Region: NorM; COG0534 991791003375 effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038 991791003376 cAMP-binding proteins - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases [Signal transduction mechanisms]; Region: Crp; COG0664 991791003377 ligand binding site [chemical binding]; other site 991791003378 flexible hinge region; other site 991791003379 Crp-like helix-turn-helix domain; Region: HTH_Crp_2; pfam13545 991791003380 Ferredoxin [Energy production and conversion]; Region: COG1146 991791003381 4Fe-4S binding domain; Region: Fer4; cl02805 991791003382 Adenine deaminase [Nucleotide transport and metabolism]; Region: AdeC; COG1001 991791003383 Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281 991791003384 Adenine deaminase (AdeC) directly deaminates adenine to form hypoxanthine. This reaction is part of one of the adenine salvage pathways, as well as the degradation pathway. It is important for adenine utilization as a purine, as well as a nitrogen source...; Region: AdeC; cd01295 991791003385 active site 991791003386 Adenine deaminase C-terminal domain; Region: Adenine_deam_C; pfam13382 991791003387 Phosphoglycerol transferase and related proteins, alkaline phosphatase superfamily [Cell envelope biogenesis, outer membrane]; Region: MdoB; COG1368 991791003388 Sulfatase; Region: Sulfatase; pfam00884 991791003389 Predicted multitransmembrane protein [Function unknown]; Region: COG5438 991791003390 Predicted multitransmembrane protein [Function unknown]; Region: COG5438 991791003391 3-deoxy-7-phosphoheptulonate synthase; Reviewed; Region: PRK08673 991791003392 phospho-2-dehydro-3-deoxyheptonate aldolase; Region: DAHP_synth_Bsub; TIGR01361 991791003393 Prephenate dehydrogenase [Amino acid transport and metabolism]; Region: TyrA; COG0287 991791003394 prephenate dehydrogenase; Validated; Region: PRK08507 991791003395 Dehydroquinate synthase (DHQS) catalyzes the conversion of DAHP to DHQ in shikimate pathway for aromatic compounds synthesis; Region: DHQS; cd08195 991791003396 Iron-containing alcohol dehydrogenase; Region: Fe-ADH; pfam00465 991791003397 active site 991791003398 dimer interface [polypeptide binding]; other site 991791003399 metal binding site [ion binding]; metal-binding site 991791003400 5-enolpyruvylshikimate-3-phosphate synthase [Amino acid transport and metabolism]; Region: AroA; COG0128 991791003401 EPSP synthase domain. 3-phosphoshikimate 1-carboxyvinyltransferase (5-enolpyruvylshikimate-3-phosphate synthase) (EC 2.5.1.19) catalyses the reaction between shikimate-3-phosphate (S3P) and phosphoenolpyruvate (PEP) to form...; Region: EPSP_synthase; cd01556 991791003402 hinge; other site 991791003403 active site 991791003404 Chorismate synthase [Amino acid transport and metabolism]; Region: AroC; COG0082 991791003405 Chorismase synthase, the enzyme catalyzing the final step of the shikimate pathway; Region: Chorismate_synthase; cd07304 991791003406 Tetramer interface [polypeptide binding]; other site 991791003407 active site 991791003408 FMN-binding site [chemical binding]; other site 991791003409 monofunctional chorismate mutase, gram positive-type, clade 2; Region: CM_mono_grmpos; TIGR01805 991791003410 Shikimate 5-dehydrogenase [Amino acid transport and metabolism]; Region: AroE; COG0169 991791003411 Shikimate dehydrogenase substrate binding domain; Region: Shikimate_dh_N; pfam08501 991791003412 NAD(P) binding domain of Shikimate dehydrogenase; Region: NAD_bind_Shikimate_DH; cd01065 991791003413 shikimate binding site; other site 991791003414 NAD(P) binding site [chemical binding]; other site 991791003415 Shikimate kinase [Amino acid transport and metabolism]; Region: AroK; COG0703 991791003416 Shikimate kinase (SK) is the fifth enzyme in the shikimate pathway, a seven-step biosynthetic pathway which converts erythrose-4-phosphate to chorismic acid, found in bacteria, fungi and plants. Chorismic acid is a important intermediate in the synthesis...; Region: SK; cd00464 991791003417 ADP binding site [chemical binding]; other site 991791003418 magnesium binding site [ion binding]; other site 991791003419 putative shikimate binding site; other site 991791003420 Dehydroquinase class II; Region: DHquinase_II; pfam01220 991791003421 Dehydroquinase (DHQase), type II. Dehydroquinase (or 3-dehydroquinate dehydratase) catalyzes the reversible dehydration of 3-dehydroquinate to form 3-dehydroshikimate. This reaction is part of two metabolic pathways: the biosynthetic shikimate pathway...; Region: DHQase_II; cd00466 991791003422 trimer interface [polypeptide binding]; other site 991791003423 active site 991791003424 dimer interface [polypeptide binding]; other site 991791003425 Endodeoxyribonuclease RusA; Region: RusA; pfam05866 991791003426 UGMP family protein; Validated; Region: PRK09604 991791003427 Inactive homolog of metal-dependent proteases, putative molecular chaperone [Posttranslational modification, protein turnover, chaperones]; Region: COG1214; cl17884 991791003428 phosphate regulon sensor kinase PhoR; Region: phoR_proteo; TIGR02966 991791003429 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 991791003430 putative active site [active] 991791003431 heme pocket [chemical binding]; other site 991791003432 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 991791003433 dimer interface [polypeptide binding]; other site 991791003434 phosphorylation site [posttranslational modification] 991791003435 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 991791003436 ATP binding site [chemical binding]; other site 991791003437 Mg2+ binding site [ion binding]; other site 991791003438 G-X-G motif; other site 991791003439 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 991791003440 ATPases associated with a variety of cellular activities; Region: AAA; smart00382 991791003441 Walker A motif; other site 991791003442 ATP binding site [chemical binding]; other site 991791003443 Walker B motif; other site 991791003444 arginine finger; other site 991791003445 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 991791003446 ATPases associated with a variety of cellular activities; Region: AAA; smart00382 991791003447 Walker A motif; other site 991791003448 ATP binding site [chemical binding]; other site 991791003449 Walker B motif; other site 991791003450 C-terminal, D2-small domain, of ClpB protein; Region: ClpB_D2-small; pfam10431 991791003451 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox_2; pfam07992 991791003452 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500 991791003453 Predicted metal-dependent hydrolases related to alanyl-tRNA synthetase HxxxH domain [General function prediction only]; Region: COG2872 991791003454 Threonyl and Alanyl tRNA synthetase second additional domain; Region: tRNA_SAD; smart00863 991791003455 Uncharacterized protein family UPF0047; Region: UPF0047; pfam01894 991791003456 Dinucleotide-utilizing enzymes involved in molybdopterin and thiamine biosynthesis family 1 [Coenzyme metabolism]; Region: COG1179 991791003457 Family of activating enzymes (E1) of ubiquitin-like proteins related to the E.coli hypothetical protein ygdL. The common reaction mechanism catalyzed by E1-like enzymes begins with a nucleophilic attack of the C-terminal carboxylate of the ubiquitin-like...; Region: YgdL_like; cd00755 991791003458 putative ATP binding site [chemical binding]; other site 991791003459 putative substrate interface [chemical binding]; other site 991791003460 Cache domain; Region: Cache_1; pfam02743 991791003461 Methyl-accepting chemotaxis protein [Cell motility and secretion / Signal transduction mechanisms]; Region: Tar; COG0840 991791003462 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 991791003463 dimerization interface [polypeptide binding]; other site 991791003464 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 991791003465 dimer interface [polypeptide binding]; other site 991791003466 putative CheW interface [polypeptide binding]; other site 991791003467 Cellulose binding domain; Region: CBM_3; pfam00942 991791003468 Carbohydrate binding domain X2; Region: CBM_X2; pfam03442 991791003469 Carbohydrate binding domain X2; Region: CBM_X2; pfam03442 991791003470 Type I cohesin domain, interaction partner of dockerin; Region: Type_I_cohesin_like; cd08548 991791003471 dockerin binding interface; other site 991791003472 Endoglucanase [Carbohydrate transport and metabolism]; Region: BglC; COG2730 991791003473 Carbohydrate binding domain X2; Region: CBM_X2; pfam03442 991791003474 Type I cohesin domain, interaction partner of dockerin; Region: Type_I_cohesin_like; cd08548 991791003475 dockerin binding interface; other site 991791003476 Carbohydrate binding domain X2; Region: CBM_X2; pfam03442 991791003477 Type I cohesin domain, interaction partner of dockerin; Region: Type_I_cohesin_like; cd08548 991791003478 dockerin binding interface; other site 991791003479 Carbohydrate binding domain X2; Region: CBM_X2; pfam03442 991791003480 Type I cohesin domain, interaction partner of dockerin; Region: Type_I_cohesin_like; cd08548 991791003481 dockerin binding interface; other site 991791003482 Carbohydrate binding domain X2; Region: CBM_X2; pfam03442 991791003483 Type I cohesin domain, interaction partner of dockerin; Region: Type_I_cohesin_like; cd08548 991791003484 dockerin binding interface; other site 991791003485 Glycosyl hydrolase family 48; Region: Glyco_hydro_48; pfam02011 991791003486 Endoglucanase [Carbohydrate transport and metabolism]; Region: BglC; COG2730 991791003487 Cellulase (glycosyl hydrolase family 5); Region: Cellulase; pfam00150 991791003488 Dockerin type I repeat; Region: Dockerin_1; pfam00404 991791003489 endoglucanase; Region: PLN02420 991791003490 Glycosyl hydrolase family 9; Region: Glyco_hydro_9; pfam00759 991791003491 Cellulose binding domain; Region: CBM_3; pfam00942 991791003492 Dockerin type I repeat; Region: Dockerin_1; pfam00404 991791003493 Type I cohesin domain, interaction partner of dockerin; Region: Type_I_cohesin_like; cd08548 991791003494 dockerin binding interface; other site 991791003495 Glycoside hydrolase family 44; Region: Glyco_hydro_44; pfam12891 991791003496 endoglucanase; Region: PLN02420 991791003497 Glycosyl hydrolase family 9; Region: Glyco_hydro_9; pfam00759 991791003498 Cellulose binding domain; Region: CBM_3; smart01067 991791003499 endoglucanase; Region: PLN02420 991791003500 Glycosyl hydrolase family 9; Region: Glyco_hydro_9; pfam00759 991791003501 Sugar-binding cellulase-like; Region: Cellulase-like; pfam12876 991791003502 Glycosyl hydrolase catalytic core; Region: Glyco_hydro_cc; pfam11790 991791003503 Dockerin type I repeat; Region: Dockerin_1; pfam00404 991791003504 VPS10 domain; Region: VPS10; smart00602 991791003505 Dockerin type I repeat; Region: Dockerin_1; pfam00404 991791003506 macrophage migration inhibitory factor-like protein; Provisional; Region: PTZ00450 991791003507 4-Oxalocrotonate Tautomerase: Catalyzes the isomerization of unsaturated ketones. The structure is a homohexamer that is arranged as a trimer of dimers. The hexamer contains six active sites, each formed by residues from three monomers, two from one...; Region: 4Oxalocrotonate_Tautomerase; cl00235 991791003508 Metal-dependent amidase/aminoacylase/carboxypeptidase [General function prediction only]; Region: AbgB; COG1473 991791003509 M20 Peptidase Aminoacyclase-1 YxeP-like proteins, including YxeP, YtnL, YjiB and HipO2; Region: M20_Acy1_YxeP_like; cd05669 991791003510 metal binding site [ion binding]; metal-binding site 991791003511 dimer interface [polypeptide binding]; other site 991791003512 WXG100 family type VII secretion target; Region: WXG100_ESAT6; TIGR03930 991791003513 Tropomyosin like; Region: Tropomyosin_1; pfam12718 991791003514 TPR repeat; Region: TPR_11; pfam13414 991791003515 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 991791003516 binding surface 991791003517 TPR motif; other site 991791003518 TPR repeat; Region: TPR_11; pfam13414 991791003519 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 991791003520 binding surface 991791003521 TPR motif; other site 991791003522 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 991791003523 binding surface 991791003524 TPR motif; other site 991791003525 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 991791003526 binding surface 991791003527 TPR motif; other site 991791003528 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4842 991791003529 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 991791003530 S-adenosylmethionine binding site [chemical binding]; other site 991791003531 DNA methylase; Region: N6_N4_Mtase; cl17433 991791003532 cystathionine beta-lyase; Provisional; Region: PRK07671 991791003533 CGS_like: Cystathionine gamma-synthase is a PLP dependent enzyme and catalyzes the committed step of methionine biosynthesis. This pathway is unique to microorganisms and plants, rendering the enzyme an attractive target for the development of...; Region: CGS_like; cd00614 991791003534 homodimer interface [polypeptide binding]; other site 991791003535 substrate-cofactor binding pocket; other site 991791003536 pyridoxal 5'-phosphate binding site [chemical binding]; other site 991791003537 catalytic residue [active] 991791003538 Cysteine synthase [Amino acid transport and metabolism]; Region: CysK; COG0031 991791003539 CBS_like: This subgroup includes Cystathionine beta-synthase (CBS) and Cysteine synthase. CBS is a unique heme-containing enzyme that catalyzes a pyridoxal 5'-phosphate (PLP)-dependent condensation of serine and homocysteine to give cystathionine; Region: CBS_like; cd01561 991791003540 dimer interface [polypeptide binding]; other site 991791003541 pyridoxal 5'-phosphate binding site [chemical binding]; other site 991791003542 catalytic residue [active] 991791003543 Uncharacterized small protein (DUF2292); Region: DUF2292; pfam10055 991791003544 Winged helix-turn-helix DNA-binding; Region: HTH_24; pfam13412 991791003545 Transcriptional regulator/sugar kinase [Transcription / Carbohydrate transport and metabolism]; Region: NagC; COG1940 991791003546 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cl17037 991791003547 phosphodiesterase; Provisional; Region: PRK12704 991791003548 ATP phosphoribosyltransferase involved in histidine biosynthesis [Amino acid transport and metabolism]; Region: HisZ; COG3705 991791003549 Class II Histidinyl-tRNA synthetase (HisRS)-like catalytic core domain. HisRS is a homodimer. It is responsible for the attachment of histidine to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for...; Region: HisRS-like_core; cd00773 991791003550 dimer interface [polypeptide binding]; other site 991791003551 motif 1; other site 991791003552 active site 991791003553 motif 2; other site 991791003554 motif 3; other site 991791003555 ATP phosphoribosyltransferase catalytic subunit; Reviewed; Region: hisG; PRK01686 991791003556 ATP phosphoribosyltransferase [Amino acid transport and metabolism]; Region: HisG; COG0040 991791003557 Histidinol dehydrogenase [Amino acid transport and metabolism]; Region: HisD; COG0141 991791003558 Histidinol dehydrogenase, HisD, E.C 1.1.1.23. Histidinol dehydrogenase catalyzes the last two steps in the L-histidine biosynthesis pathway, which is conserved in bacteria, archaea, fungi, and plants. These last two steps are (i) the NAD-dependent...; Region: Histidinol_dh; cd06572 991791003559 NAD binding site [chemical binding]; other site 991791003560 dimerization interface [polypeptide binding]; other site 991791003561 product binding site; other site 991791003562 substrate binding site [chemical binding]; other site 991791003563 zinc binding site [ion binding]; other site 991791003564 catalytic residues [active] 991791003565 Imidazoleglycerol-phosphate dehydratase; Region: IGPD; cd07914 991791003566 putative active site pocket [active] 991791003567 4-fold oligomerization interface [polypeptide binding]; other site 991791003568 metal binding residues [ion binding]; metal-binding site 991791003569 3-fold/trimer interface [polypeptide binding]; other site 991791003570 imidazole glycerol phosphate synthase subunit HisH; Provisional; Region: hisH; PRK13141 991791003571 Type 1 glutamine amidotransferase (GATase1) domain found in imidazole glycerol phosphate synthase (IGPS); Region: GATase1_IGP_Synthase; cd01748 991791003572 putative active site [active] 991791003573 oxyanion strand; other site 991791003574 catalytic triad [active] 991791003575 HisA. Phosphoribosylformimino-5-aminoimidazole carboxamide ribonucleotide (ProFAR) isomerase catalyzes the fourth step in histidine biosynthesis, an isomerisation of the aminoaldose moiety of ProFAR to the aminoketose of PRFAR (N-(5'-phospho-D-1...; Region: HisA; cd04732 991791003576 phosphoribosylformimino-5-aminoimidazole carboxamide ribotide isomerase; Region: TIGR00007 991791003577 catalytic residues [active] 991791003578 The cyclase subunit of imidazoleglycerol phosphate synthase (HisF). Imidazole glycerol phosphate synthase (IGPS) catalyzes the fifth step of histidine biosynthesis, the formation of the imidazole ring. IGPS converts N1-(5'-phosphoribulosyl)...; Region: HisF; cd04731 991791003579 Histidine biosynthesis protein; Region: His_biosynth; pfam00977 991791003580 substrate binding site [chemical binding]; other site 991791003581 glutamase interaction surface [polypeptide binding]; other site 991791003582 phosphoribosyl-AMP cyclohydrolase; Reviewed; Region: hisI; PRK00051 991791003583 Nucleoside Triphosphate Pyrophosphohydrolase (EC 3.6.1.8) MazG-like domain found in Escherichia coli phosphoribosyl-ATP pyrophosphohydrolase (HisIE or PRATP-PH) and its homologs; Region: NTP-PPase_HisIE_like; cd11534 991791003584 metal binding site [ion binding]; metal-binding site 991791003585 Transketolase [Carbohydrate transport and metabolism]; Region: TktA; COG0021 991791003586 Thiamine pyrophosphate (TPP) family, Transketolase (TK) subfamily, TPP-binding module; TK catalyzes the transfer of a two-carbon unit from ketose phosphates to aldose phosphates. In heterotrophic organisms, TK provides a link between glycolysis and the...; Region: TPP_TK; cd02012 991791003587 TPP-binding site [chemical binding]; other site 991791003588 dimer interface [polypeptide binding]; other site 991791003589 Pyrimidine (PYR) binding domain of 1-deoxy-D-xylulose-5-phosphate synthase (DXS), transketolase (TK), and related proteins; Region: TPP_PYR_DXS_TK_like; cd07033 991791003590 PYR/PP interface [polypeptide binding]; other site 991791003591 dimer interface [polypeptide binding]; other site 991791003592 TPP binding site [chemical binding]; other site 991791003593 Transketolase, C-terminal domain; Region: Transketolase_C; pfam02780 991791003594 Single-stranded DNA-binding protein [DNA replication, recombination, and repair]; Region: Ssb; COG0629 991791003595 SSB_OBF: A subfamily of OB folds similar to the OB fold of ssDNA-binding protein (SSB). SSBs bind with high affinity to ssDNA. They bind to and protect ssDNA intermediates during DNA metabolic pathways. All bacterial and eukaryotic SSBs studied to date...; Region: SSB_OBF; cd04496 991791003596 dimer interface [polypeptide binding]; other site 991791003597 ssDNA binding site [nucleotide binding]; other site 991791003598 tetramer (dimer of dimers) interface [polypeptide binding]; other site 991791003599 Predicted hydrolase (metallo-beta-lactamase superfamily) [General function prediction only]; Region: ComEC; COG2333 991791003600 Metallo-beta-lactamase superfamily; Region: Lactamase_B; smart00849 991791003601 Predicted membrane protein, hemolysin III homolog [General function prediction only]; Region: COG1272 991791003602 channel protein, hemolysin III family; Region: hlyIII; TIGR01065 991791003603 EDD domain protein, DegV family; Region: DegV; TIGR00762 991791003604 Uncharacterized protein, DegV family COG1307; Region: DegV; pfam02645 991791003605 Predicted transcriptional regulators [Transcription]; Region: COG1695 991791003606 Transcriptional regulator PadR-like family; Region: PadR; pfam03551 991791003607 Predicted membrane protein [Function unknown]; Region: COG1971 991791003608 Domain of unknown function DUF; Region: DUF204; pfam02659 991791003609 Domain of unknown function DUF; Region: DUF204; pfam02659 991791003610 ferric uptake regulator; Provisional; Region: fur; PRK09462 991791003611 Ferric uptake regulator(Fur) and related metalloregulatory proteins; typically iron-dependent, DNA-binding repressors and activators; Region: Fur_like; cd07153 991791003612 metal binding site 2 [ion binding]; metal-binding site 991791003613 putative DNA binding helix; other site 991791003614 metal binding site 1 [ion binding]; metal-binding site 991791003615 dimer interface [polypeptide binding]; other site 991791003616 structural Zn2+ binding site [ion binding]; other site 991791003617 Rhomboid family; Region: Rhomboid; pfam01694 991791003618 ATP-dependent Zn proteases [Posttranslational modification, protein turnover, chaperones]; Region: HflB; COG0465 991791003619 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 991791003620 Walker A motif; other site 991791003621 ATP binding site [chemical binding]; other site 991791003622 Walker B motif; other site 991791003623 arginine finger; other site 991791003624 Peptidase family M41; Region: Peptidase_M41; pfam01434 991791003625 Gas vesicle protein [General function prediction only]; Region: GvpP; COG4980 991791003626 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 991791003627 non-specific DNA binding site [nucleotide binding]; other site 991791003628 salt bridge; other site 991791003629 sequence-specific DNA binding site [nucleotide binding]; other site 991791003630 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cl02429 991791003631 binding surface 991791003632 TPR motif; other site 991791003633 Tetratricopeptide repeat; Region: TPR_12; pfam13424 991791003634 Tetratricopeptide repeat; Region: TPR_12; pfam13424 991791003635 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cl02429 991791003636 binding surface 991791003637 TPR motif; other site 991791003638 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 991791003639 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 991791003640 non-specific DNA binding site [nucleotide binding]; other site 991791003641 salt bridge; other site 991791003642 sequence-specific DNA binding site [nucleotide binding]; other site 991791003643 ATP-dependent chaperone ClpB; Region: chaperone_ClpB; TIGR03346 991791003644 Clp amino terminal domain; Region: Clp_N; pfam02861 991791003645 Clp amino terminal domain; Region: Clp_N; pfam02861 991791003646 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 991791003647 Walker A motif; other site 991791003648 ATP binding site [chemical binding]; other site 991791003649 Walker B motif; other site 991791003650 arginine finger; other site 991791003651 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 991791003652 Walker A motif; other site 991791003653 ATP binding site [chemical binding]; other site 991791003654 Walker B motif; other site 991791003655 arginine finger; other site 991791003656 C-terminal, D2-small domain, of ClpB protein; Region: ClpB_D2-small; pfam10431 991791003657 Predicted xylanase/chitin deacetylase [Carbohydrate transport and metabolism]; Region: CDA1; COG0726 991791003658 Catalytic NodB homology domain of Streptococcus mutans polysaccharide deacetylase PgdA, Bacillus subtilis YheN, and similar proteins; Region: CE4_SmPgdA_like; cd10944 991791003659 NodB motif; other site 991791003660 active site 991791003661 catalytic site [active] 991791003662 Zn binding site [ion binding]; other site 991791003663 Type 1 glutamine amidotransferase (GATase1) domain found in Cobyric Acid Synthase (CobQ); Region: GATase1_CobQ; cd01750 991791003664 catalytic triad [active] 991791003665 UDP-N-acetylmuramyl tripeptide synthase [Cell envelope biogenesis, outer membrane]; Region: MurE; COG0769 991791003666 Mur ligase middle domain; Region: Mur_ligase_M; pfam08245 991791003667 Domain of unknown function (DUF1727); Region: DUF1727; pfam08353 991791003668 undecaprenyl pyrophosphate phosphatase; Reviewed; Region: PRK12554 991791003669 1-acyl-sn-glycerol-3-phosphate acyltransferase [Lipid metabolism]; Region: PlsC; COG0204 991791003670 Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: AGPAT-like; Region: LPLAT_AGPAT-like; cd07989 991791003671 putative acyl-acceptor binding pocket; other site 991791003672 Isopropylmalate/homocitrate/citramalate synthases [Amino acid transport and metabolism]; Region: LeuA; COG0119 991791003673 Clostridium kluyveri Re-citrate synthase and related proteins, catalytic TIM barrel domain; Region: DRE_TIM_Re_CS; cd07947 991791003674 active site 991791003675 catalytic residues [active] 991791003676 metal binding site [ion binding]; metal-binding site 991791003677 aconitate hydratase; Validated; Region: PRK07229 991791003678 Aconitase catalyzes the reversible isomerization of citrate and isocitrate as part of the TCA cycle; Region: AcnA_Bact; cd01585 991791003679 substrate binding site [chemical binding]; other site 991791003680 ligand binding site [chemical binding]; other site 991791003681 Aconitase swivel domain. Aconitase (aconitate hydratase) catalyzes the reversible isomerization of citrate and isocitrate as part of the TCA cycle. This is the aconitase swivel domain, which undergoes swivelling conformational change in the enzyme...; Region: Aconitase_swivel; cl00215 991791003682 substrate binding site [chemical binding]; other site 991791003683 Isocitrate/isopropylmalate dehydrogenase [Amino acid transport and metabolism]; Region: LeuB; COG0473 991791003684 isocitrate dehydrogenase; Validated; Region: PRK06451 991791003685 argininosuccinate synthase; Provisional; Region: PRK13820 991791003686 Argininosuccinate synthase. The Argininosuccinate synthase is a urea cycle enzyme that catalyzes the penultimate step in arginine biosynthesis: the ATP-dependent ligation of citrulline to aspartate to form argininosuccinate, AMP and pyrophosphate . In...; Region: Argininosuccinate_Synthase; cd01999 991791003687 ANP binding site [chemical binding]; other site 991791003688 Substrate Binding Site II [chemical binding]; other site 991791003689 Substrate Binding Site I [chemical binding]; other site 991791003690 argininosuccinate lyase; Provisional; Region: PRK00855 991791003691 Argininosuccinate lyase (argininosuccinase, ASAL); Region: Argininosuccinate_lyase; cd01359 991791003692 active sites [active] 991791003693 tetramer interface [polypeptide binding]; other site 991791003694 Phosphoenolpyruvate carboxykinase (PEPCK), a critical gluconeogenic enzyme, catalyzes the first committed step in the diversion of tricarboxylic acid cycle intermediates toward gluconeogenesis. It catalyzes the reversible decarboxylation and...; Region: PEPCK_HprK; cl00270 991791003695 active site 991791003696 metal-binding site [ion binding] 991791003697 nucleotide-binding site [chemical binding]; other site 991791003698 Uncharacterized conserved protein [Function unknown]; Region: COG2155 991791003699 DNA-binding transcriptional regulator AsnC; Provisional; Region: PRK11179 991791003700 AsnC-type helix-turn-helix domain; Region: HTH_AsnC-type; pfam13404 991791003701 putative DNA binding site [nucleotide binding]; other site 991791003702 putative Zn2+ binding site [ion binding]; other site 991791003703 AsnC family; Region: AsnC_trans_reg; pfam01037 991791003704 Predicted exonuclease [DNA replication, recombination, and repair]; Region: COG3359 991791003705 RNase_H superfamily; Region: RNase_H_2; pfam13482 991791003706 active site 991791003707 substrate binding site [chemical binding]; other site 991791003708 FOG: CBS domain [General function prediction only]; Region: COG0517 991791003709 The CBS domain, named after human CBS, is a small domain originally identified in cystathionine beta-synthase and is subsequently found in a wide range of different proteins. CBS domains usually occur in tandem repeats. They associate to form a so-called...; Region: CBS_pair; cd02205 991791003710 formate acetyltransferase 1; Region: pyr_form_ly_1; TIGR01255 991791003711 Pyruvate formate lyase 1; Region: PFL1; cd01678 991791003712 coenzyme A binding site [chemical binding]; other site 991791003713 active site 991791003714 catalytic residues [active] 991791003715 glycine loop; other site 991791003716 pyruvate formate-lyase 1-activating enzyme; Region: PFLA; TIGR02493 991791003717 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 991791003718 FeS/SAM binding site; other site 991791003719 PilZ domain; Region: PilZ; pfam07238 991791003720 ABC-type metal ion transport system, ATPase component [Inorganic ion transport and metabolism]; Region: AbcC; COG1135 991791003721 ATP-binding cassette domain of methionine transporter; Region: ABC_MetN_methionine_transporter; cd03258 991791003722 Walker A/P-loop; other site 991791003723 ATP binding site [chemical binding]; other site 991791003724 Q-loop/lid; other site 991791003725 ABC transporter signature motif; other site 991791003726 Walker B; other site 991791003727 D-loop; other site 991791003728 H-loop/switch region; other site 991791003729 This domain is found at the C-terminus of ABC transporter proteins involved in D-methionine transport as well as a number of ferredoxin-like proteins; Region: NIL; smart00930 991791003730 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 991791003731 dimer interface [polypeptide binding]; other site 991791003732 conserved gate region; other site 991791003733 ABC-ATPase subunit interface; other site 991791003734 ABC-type metal ion transport system, periplasmic component/surface antigen [Inorganic ion transport and metabolism]; Region: NlpA; COG1464 991791003735 NLPA lipoprotein; Region: Lipoprotein_9; pfam03180 991791003736 RNase_H superfamily; Region: RNase_H_2; pfam13482 991791003737 glutamyl-tRNA synthetase; Reviewed; Region: gltX; PRK01406 991791003738 catalytic core domain of discriminating glutamyl-tRNA synthetase; Region: GluRS_core; cd00808 991791003739 active site 991791003740 HIGH motif; other site 991791003741 catalytic core domain of discriminating glutamyl-tRNA synthetase; Region: GluRS_core; cd00808 991791003742 active site 991791003743 KMSKS motif; other site 991791003744 intracellular protease, PfpI family; Region: PfpI; TIGR01382 991791003745 A type 1 glutamine amidotransferase (GATase1)-like domain found in PfpI from Pyrococcus furiosus; Region: GATase1_PfpI_like; cd03134 991791003746 proposed catalytic triad [active] 991791003747 conserved cys residue [active] 991791003748 Protein of unknown function, DUF488; Region: DUF488; pfam04343 991791003749 D-alanyl-D-alanine carboxypeptidase; Region: Peptidase_S11; pfam00768 991791003750 Beta-lactamase enzyme family; Region: Beta-lactamase2; cl17872 991791003751 Nucleoside diphosphate kinase [Nucleotide transport and metabolism]; Region: Ndk; COG0105 991791003752 multimer interface [polypeptide binding]; other site 991791003753 homoserine dehydrogenase; Provisional; Region: PRK06349 991791003754 Homoserine dehydrogenase, NAD binding domain; Region: NAD_binding_3; pfam03447 991791003755 Homoserine dehydrogenase; Region: Homoserine_dh; pfam00742 991791003756 ACT_HSDH_Hom CD includes the C-terminal ACT domain of the NAD(P)H-dependent, homoserine dehydrogenase (HSDH) and related domains; Region: ACT_HSDH-Hom; cd04881 991791003757 Threonine synthase [Amino acid transport and metabolism]; Region: ThrC; COG0498 991791003758 Threonine synthase catalyzes the final step of threonine biosynthesis. The conversion of O-phosphohomoserine into threonine and inorganic phosphate is pyridoxal 5'-phosphate dependent. The Thr-synth_1 CD includes members from higher plants; Region: Thr-synth_2; cd01560 991791003759 pyridoxal 5'-phosphate binding site [chemical binding]; other site 991791003760 catalytic residue [active] 991791003761 ASC-1 homology domain, subfamily similar to Enterococcus faecalis Ef3133. The ASCH domain, a small beta-barrel domain found in all three kingdoms of life, resembles the RNA-binding PUA domain and may also interact with RNA. ASCH has been proposed to...; Region: ASCH_Ef3133_like; cd06553 991791003762 aspartate aminotransferase; Provisional; Region: PRK07568 991791003763 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 991791003764 pyridoxal 5'-phosphate binding site [chemical binding]; other site 991791003765 homodimer interface [polypeptide binding]; other site 991791003766 catalytic residue [active] 991791003767 nicotinate phosphoribosyltransferase; Validated; Region: PRK09243 991791003768 Nicotinate phosphoribosyltransferase (NAPRTase), subgroup A. Nicotinate phosphoribosyltransferase catalyses the formation of NAMN and PPi from 5-phosphoribosy -1-pyrophosphate (PRPP) and nicotinic acid, this is the first, and also rate limiting, reaction...; Region: NAPRTase_A; cd01570 991791003769 active site 991791003770 Superfamily I DNA and RNA helicases [DNA replication, recombination, and repair]; Region: UvrD; COG0210 991791003771 Part of AAA domain; Region: AAA_19; pfam13245 991791003772 Family description; Region: UvrD_C_2; pfam13538 991791003773 Nudix hydrolase is a superfamily of enzymes found in all three kingdoms of life, and it catalyzes the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+...; Region: Nudix_Hydrolase; cl00447 991791003774 nudix motif; other site 991791003775 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 991791003776 Coenzyme A binding pocket [chemical binding]; other site 991791003777 Putative peptidoglycan-binding domain-containing protein [Cell envelope biogenesis, outer membrane]; Region: COG3409 991791003778 Putative peptidoglycan binding domain; Region: PG_binding_1; pfam01471 991791003779 Putative peptidoglycan binding domain; Region: PG_binding_1; pfam01471 991791003780 D-alanyl-D-alanine carboxypeptidase; Region: VanY; pfam02557 991791003781 Calcineurin-like phosphoesterase; Region: Metallophos; pfam00149 991791003782 metallophosphatase superfamily, metallophosphatase domain; Region: MPP_superfamily; cl13995 991791003783 active site 991791003784 metal binding site [ion binding]; metal-binding site 991791003785 Uncharacterized conserved protein [Function unknown]; Region: COG3339 991791003786 Predicted membrane protein [Function unknown]; Region: COG2246 991791003787 GtrA-like protein; Region: GtrA; pfam04138 991791003788 Cell division ATPase FtsA [Cell division and chromosome partitioning]; Region: ftsA; COG0849 991791003789 Cell division protein FtsA; Region: FtsA; smart00842 991791003790 Cell division protein FtsA; Region: FtsA; pfam14450 991791003791 Metal-dependent amidase/aminoacylase/carboxypeptidase [General function prediction only]; Region: AbgB; COG1473 991791003792 M20 Peptidase Aminoacylase 1 family; Region: M20_Acy1; cd03886 991791003793 metal binding site [ion binding]; metal-binding site 991791003794 dimer interface [polypeptide binding]; other site 991791003795 Pseudouridylate synthases, 23S RNA-specific [Translation, ribosomal structure and biogenesis]; Region: RluA; COG0564 991791003796 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 991791003797 RNA binding surface [nucleotide binding]; other site 991791003798 Pseudouridine synthase, RsuA/RluD family; Region: PseudoU_synth_RluCD_like; cd02869 991791003799 active site 991791003800 Membrane protein involved in the export of O-antigen and teichoic acid [General function prediction only]; Region: RfbX; COG2244 991791003801 Stage V sporulation protein B, also known as Stage III sporulation protein F, and related proteins; Region: MATE_SpoVB_like; cd13124 991791003802 stage V sporulation protein B; Region: spore_V_B; TIGR02900 991791003803 Multidrug and toxic compound extrusion family and similar proteins; Region: MATE_like; cl09326 991791003804 Glucose/sorbosone dehydrogenases [Carbohydrate transport and metabolism]; Region: COG2133 991791003805 Zinc dependent phospholipase C (alpha toxin); Region: Zn_dep_PLPC; cd11009 991791003806 Fe-S oxidoreductase [Energy production and conversion]; Region: COG1032 991791003807 B12 binding domain_like associated with radical SAM domain. This domain shows similarity with B12 (adenosylcobamide) binding domains found in several enzymes, such as glutamate mutase, methionine synthase and methylmalonyl-CoA mutase, but it lacks the...; Region: radical_SAM_B12_BD; cd02068 991791003808 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 991791003809 FeS/SAM binding site; other site 991791003810 Protein of unknown function (DUF4080); Region: DUF4080; pfam13311 991791003811 Predicted thioesterase involved in non-ribosomal peptide biosynthesis [Secondary metabolites biosynthesis, transport, and catabolism]; Region: GrsT; COG3208 991791003812 Nicotinate-nucleotide pyrophosphorylase [Coenzyme metabolism]; Region: NadC; COG0157 991791003813 Quinolinate phosphoribosyl transferase (QAPRTase or QPRTase), also called nicotinate-nucleotide pyrophosphorylase, is involved in the de novo synthesis of NAD in both prokaryotes and eukaryotes. It catalyses the reaction of quinolinic acid (QA) with...; Region: QPRTase; cd01572 991791003814 dimerization interface [polypeptide binding]; other site 991791003815 active site 991791003816 L-aspartate oxidase; Provisional; Region: PRK06175 991791003817 FAD binding domain; Region: FAD_binding_2; pfam00890 991791003818 Quinolinate synthetase A protein; Region: NadA; pfam02445 991791003819 Superfamily I DNA and RNA helicases [General function prediction only]; Region: COG3973 991791003820 Part of AAA domain; Region: AAA_19; pfam13245 991791003821 Uncharacterized flavoproteins [Energy production and conversion]; Region: FpaA; COG0426 991791003822 Metallo-beta-lactamase superfamily; Region: Lactamase_B; smart00849 991791003823 Flavodoxin-like fold; Region: Flavodoxin_2; cl00438 991791003824 Predicted acetyltransferases and hydrolases with the alpha/beta hydrolase fold [General function prediction only]; Region: LipA; COG1075 991791003825 Fe2+ transport system protein A [Inorganic ion transport and metabolism]; Region: FeoA; COG1918 991791003826 Fe2+ transport system protein A [Inorganic ion transport and metabolism]; Region: FeoA; COG1918 991791003827 Fe2+ transport system protein B [Inorganic ion transport and metabolism]; Region: FeoB; COG0370 991791003828 Ferrous iron transport protein B (FeoB) family; Region: FeoB; cd01879 991791003829 G1 box; other site 991791003830 GTP/Mg2+ binding site [chemical binding]; other site 991791003831 Switch I region; other site 991791003832 G2 box; other site 991791003833 G3 box; other site 991791003834 Switch II region; other site 991791003835 G4 box; other site 991791003836 G5 box; other site 991791003837 Nucleoside recognition; Region: Gate; pfam07670 991791003838 Ferrous iron transport protein B C terminus; Region: FeoB_C; pfam07664 991791003839 Nucleoside recognition; Region: Gate; pfam07670 991791003840 CRISPR/Cas system-associated transcriptional regulator CasRa; Region: CasRa_I-A; cd09655 991791003841 HNH nucleases; HNH endonuclease signature which is found in viral, prokaryotic, and eukaryotic proteins. The alignment includes members of the large group of homing endonucleases, yeast intron 1 protein, MutS, as well as bacterial colicins, pyocins, and...; Region: HNHc; cd00085 991791003842 active site 991791003843 Pyruvate kinase [Carbohydrate transport and metabolism]; Region: PykF; COG0469 991791003844 Pyruvate kinase (PK): Large allosteric enzyme that regulates glycolysis through binding of the substrate, phosphoenolpyruvate, and one or more allosteric effectors. Like other allosteric enzymes, PK has a high substrate affinity R state and a low...; Region: Pyruvate_Kinase; cl17342 991791003845 domain interfaces; other site 991791003846 active site 991791003847 Predicted xylanase/chitin deacetylase [Carbohydrate transport and metabolism]; Region: CDA1; COG0726 991791003848 Catalytic NodB homology domain of Streptococcus mutans polysaccharide deacetylase PgdA, Bacillus subtilis YheN, and similar proteins; Region: CE4_SmPgdA_like; cd10944 991791003849 NodB motif; other site 991791003850 active site 991791003851 catalytic site [active] 991791003852 Zn binding site [ion binding]; other site 991791003853 zinc-ribbon domain; Region: zf-ribbon_3; pfam13248 991791003854 Double zinc ribbon; Region: DZR; pfam12773 991791003855 integral membrane protein, YjbE family; Region: R_switched_YjbE; TIGR03717 991791003856 Imidazolonepropionase and related amidohydrolases [Secondary metabolites biosynthesis, transport, and catabolism]; Region: HutI; COG1228 991791003857 Metallo-dependent hydrolases, subgroup C is part of the superfamily of metallo-dependent hydrolases, a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the...; Region: Met_dep_hydrolase_C; cd01309 991791003858 active site 991791003859 arginyl-tRNA synthetase; Reviewed; Region: PRK12451 991791003860 Arginyl tRNA synthetase N terminal dom; Region: Arg_tRNA_synt_N; smart01016 991791003861 catalytic core domain of arginyl-tRNA synthetases; Region: ArgRS_core; cd00671 991791003862 active site 991791003863 HIGH motif; other site 991791003864 KMSK motif region; other site 991791003865 Anticodon-binding domain of arginyl tRNA synthetases; Region: Anticodon_Ia_Arg; cd07956 991791003866 tRNA binding surface [nucleotide binding]; other site 991791003867 anticodon binding site; other site 991791003868 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 991791003869 non-specific DNA binding site [nucleotide binding]; other site 991791003870 salt bridge; other site 991791003871 sequence-specific DNA binding site [nucleotide binding]; other site 991791003872 NADH:flavin oxidoreductases, Old Yellow Enzyme family [Energy production and conversion]; Region: NemA; COG1902 991791003873 Old yellow enzyme (OYE)-like FMN binding domain. OYE was the first flavin-dependent enzyme identified, however its true physiological role remains elusive to this day. Each monomer of OYE contains FMN as a non-covalently bound cofactor, uses NADPH as a...; Region: OYE_like_FMN_family; cd02803 991791003874 active site 991791003875 FMN binding site [chemical binding]; other site 991791003876 substrate binding site [chemical binding]; other site 991791003877 putative catalytic residue [active] 991791003878 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox_2; pfam07992 991791003879 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 991791003880 Permeases of the drug/metabolite transporter (DMT) superfamily [Carbohydrate transport and metabolism / Amino acid transport and metabolism / General function prediction only]; Region: RhaT; COG0697 991791003881 EamA-like transporter family; Region: EamA; pfam00892 991791003882 Transcriptional regulator [Transcription]; Region: LysR; COG0583 991791003883 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 991791003884 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cd05466 991791003885 dimerization interface [polypeptide binding]; other site 991791003886 vitamin B12-dependent ribonucleotide reductase; Validated; Region: PRK06556 991791003887 Class II vitamin B12-dependent ribonucleotide reductase; Region: Ribonuc_red_2_N; pfam08471 991791003888 Class II ribonucleotide reductase, dimeric form; Region: RNR_II_dimer; cd02888 991791003889 active site 991791003890 dimer interface [polypeptide binding]; other site 991791003891 effector binding site; other site 991791003892 Ribonucleotide reductase and Pyruvate formate lyase; Region: RNR_PFL; cl09939 991791003893 TSCPD domain; Region: TSCPD; pfam12637 991791003894 Carbonic anhydrases/acetyltransferases, isoleucine patch superfamily [General function prediction only]; Region: PaaY; COG0663 991791003895 Gamma carbonic anhydrase-like: This family is composed of gamma carbonic anhydrase (CA), Ferripyochelin Binding Protein (FBP), E. coli paaY protein, and similar proteins. CAs are zinc-containing enzymes that catalyze the reversible hydration of carbon...; Region: LbH_gamma_CA_like; cd04645 991791003896 trimer interface [polypeptide binding]; other site 991791003897 putative metal binding site [ion binding]; other site 991791003898 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG1728 991791003899 NAD synthetase; Reviewed; Region: nadE; PRK02628 991791003900 Glutamine aminotransferase (GAT, glutaminase) domain of glutamine-dependent NAD synthetases (class 7 and 8 nitrilases); Region: GAT_Gln-NAD-synth; cd07570 991791003901 multimer interface [polypeptide binding]; other site 991791003902 active site 991791003903 catalytic triad [active] 991791003904 protein interface 1 [polypeptide binding]; other site 991791003905 NAD+ synthase is a homodimer, which catalyzes the final step in de novo nicotinamide adenine dinucleotide (NAD+) biosynthesis, an amide transfer from either ammonia or glutamine to nicotinic acid adenine dinucleotide (NaAD). The conversion of NaAD to NAD...; Region: NAD_synthase; cd00553 991791003906 homodimer interface [polypeptide binding]; other site 991791003907 NAD binding pocket [chemical binding]; other site 991791003908 ATP binding pocket [chemical binding]; other site 991791003909 Mg binding site [ion binding]; other site 991791003910 active-site loop [active] 991791003911 NfeD-like C-terminal, partner-binding; Region: NfeD; pfam01957 991791003912 Membrane protease subunits, stomatin/prohibitin homologs [Posttranslational modification, protein turnover, chaperones]; Region: HflC; COG0330 991791003913 Band_7_stomatin_like: A subgroup of the band 7 domain of flotillin (reggie) like proteins similar to stomatin and podicin (two lipid raft-associated integral membrane proteins). Individual proteins of this band 7 domain family may cluster to form...; Region: Band_7_stomatin_like; cd03403 991791003914 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 991791003915 This family is most closely related to the GT1 family of glycosyltransferases and named after YqgM in Bacillus licheniformis about which little is known. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to...; Region: GT1_YqgM_like; cd03801 991791003916 Arginase family; Region: Arginase; cd09989 991791003917 active site 991791003918 Mn binding site [ion binding]; other site 991791003919 oligomer interface [polypeptide binding]; other site 991791003920 Rhs family protein [Cell envelope biogenesis, outer membrane]; Region: RhsA; COG3209 991791003921 RHS repeat-associated core domain; Region: Rhs_assc_core; TIGR03696 991791003922 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 991791003923 binding surface 991791003924 TPR motif; other site 991791003925 TPR repeat; Region: TPR_11; pfam13414 991791003926 TPR repeat; Region: TPR_11; pfam13414 991791003927 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 991791003928 TPR motif; other site 991791003929 TPR repeat; Region: TPR_11; pfam13414 991791003930 binding surface 991791003931 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 991791003932 binding surface 991791003933 TPR motif; other site 991791003934 TPR repeat; Region: TPR_11; pfam13414 991791003935 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 991791003936 binding surface 991791003937 TPR motif; other site 991791003938 TPR repeat; Region: TPR_11; pfam13414 991791003939 Tetratricopeptide repeat; Region: TPR_12; pfam13424 991791003940 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 991791003941 binding surface 991791003942 TPR repeat; Region: TPR_11; pfam13414 991791003943 TPR motif; other site 991791003944 Tetratricopeptide repeat; Region: TPR_12; pfam13424 991791003945 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 991791003946 binding surface 991791003947 TPR motif; other site 991791003948 TPR repeat; Region: TPR_11; pfam13414 991791003949 HEAT repeats; Region: HEAT_2; pfam13646 991791003950 Transcriptional regulator C-terminal region; Region: TetR_C_8; pfam14278 991791003951 Acetyltransferase (GNAT) family; Region: Acetyltransf_1; pfam00583 991791003952 Acetyltransferases [General function prediction only]; Region: RimI; COG0456 991791003953 Coenzyme A binding pocket [chemical binding]; other site 991791003954 B12 binding domain_like associated with radical SAM domain. This domain shows similarity with B12 (adenosylcobamide) binding domains found in several enzymes, such as glutamate mutase, methionine synthase and methylmalonyl-CoA mutase, but it lacks the...; Region: radical_SAM_B12_BD; cd02068 991791003955 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 991791003956 Radical SAM superfamily; Region: Radical_SAM; pfam04055 991791003957 FeS/SAM binding site; other site 991791003958 Protein of unknown function (DUF2000); Region: DUF2000; pfam09391 991791003959 Beta-glucosidase-related glycosidases [Carbohydrate transport and metabolism]; Region: BglX; COG1472 991791003960 Glycosyl hydrolase family 3 N terminal domain; Region: Glyco_hydro_3; pfam00933 991791003961 Glycosyl hydrolase family 3 C-terminal domain; Region: Glyco_hydro_3_C; pfam01915 991791003962 YjgF, YER057c, and UK114 belong to a large family of proteins present in bacteria, archaea, and eukaryotes with no definitive function. The conserved domain is similar in structure to chorismate mutase but there is no sequence similarity and no...; Region: YjgF_YER057c_UK114_family; cd00448 991791003963 homotrimer interaction site [polypeptide binding]; other site 991791003964 putative active site [active] 991791003965 Calcineurin-like phosphoesterase; Region: Metallophos; pfam00149 991791003966 FOG: Glucan-binding domain (YG repeat) [General function prediction only]; Region: COG5263 991791003967 glucan-binding repeat; Region: glucan_65_rpt; TIGR04035 991791003968 FOG: Glucan-binding domain (YG repeat) [General function prediction only]; Region: COG5263 991791003969 FOG: Glucan-binding domain (YG repeat) [General function prediction only]; Region: COG5263 991791003970 FOG: Glucan-binding domain (YG repeat) [General function prediction only]; Region: COG5263 991791003971 glucan-binding repeat; Region: glucan_65_rpt; TIGR04035 991791003972 glucan-binding repeat; Region: glucan_65_rpt; TIGR04035 991791003973 glucan-binding repeat; Region: glucan_65_rpt; TIGR04035 991791003974 glucan-binding repeat; Region: glucan_65_rpt; TIGR04035 991791003975 FOG: Glucan-binding domain (YG repeat) [General function prediction only]; Region: COG5263 991791003976 glucan-binding repeat; Region: glucan_65_rpt; TIGR04035 991791003977 FOG: Glucan-binding domain (YG repeat) [General function prediction only]; Region: COG5263 991791003978 FOG: Glucan-binding domain (YG repeat) [General function prediction only]; Region: COG5263 991791003979 FOG: Glucan-binding domain (YG repeat) [General function prediction only]; Region: COG5263 991791003980 glucan-binding repeat; Region: glucan_65_rpt; TIGR04035 991791003981 glucan-binding repeat; Region: glucan_65_rpt; TIGR04035 991791003982 FOG: Glucan-binding domain (YG repeat) [General function prediction only]; Region: COG5263 991791003983 glucan-binding repeat; Region: glucan_65_rpt; TIGR04035 991791003984 Cna protein B-type domain; Region: Cna_B_2; pfam13715 991791003985 Cna protein B-type domain; Region: Cna_B_2; pfam13715 991791003986 Carboxypeptidase regulatory-like domain; Region: CarboxypepD_reg; pfam13620 991791003987 Predicted membrane-bound metal-dependent hydrolases [General function prediction only]; Region: COG1988 991791003988 Beta-glucosidase/6-phospho-beta-glucosidase/beta- galactosidase [Carbohydrate transport and metabolism]; Region: BglB; COG2723 991791003989 beta-galactosidase; Region: BGL; TIGR03356 991791003990 putative alpha-glucosidase; Provisional; Region: PRK10658 991791003991 Galactose mutarotase-like; Region: Gal_mutarotas_2; pfam13802 991791003992 YicI alpha-xylosidase is a glycosyl hydrolase family 31 (GH31) enzyme that catalyzes the release of an alpha-xylosyl residue from the non-reducing end of alpha-xyloside substrates such as alpha-xylosyl fluoride and isoprimeverose. YicI forms a...; Region: GH31_xylosidase_YicI; cd06593 991791003993 active site 991791003994 homotrimer interface [polypeptide binding]; other site 991791003995 catalytic site [active] 991791003996 homohexamer (dimer of homotrimers) interface [polypeptide binding]; other site 991791003997 Transcriptional regulator/sugar kinase [Transcription / Carbohydrate transport and metabolism]; Region: NagC; COG1940 991791003998 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cd00012 991791003999 nucleotide binding site [chemical binding]; other site 991791004000 Bacterial fructose-1,6-bisphosphatase, glpX-encoded. A dimeric enzyme dependent on Mg(2+). glpX-encoded FPBase (FBPase class II) differs from other members of the inositol-phosphatase superfamily by permutation of secondary structure elements. The core...; Region: FBPase_glpX; cd01516 991791004001 Bacterial fructose-1,6-bisphosphatase, glpX-encoded; Region: FBPase_glpX; pfam03320 991791004002 putative active site [active] 991791004003 HPr kinase/phosphorylase; Provisional; Region: PRK05428 991791004004 HPr Serine kinase N terminus; Region: Hpr_kinase_N; pfam02603 991791004005 HprK/P, the bifunctional histidine-containing protein kinase/phosphatase, controls the phosphorylation state of the phosphocarrier protein HPr and regulates the utilization of carbon sources by gram-positive bacteria. It catalyzes both the ATP-dependent...; Region: HprK_C; cd01918 991791004006 Hpr binding site; other site 991791004007 active site 991791004008 homohexamer subunit interaction site [polypeptide binding]; other site 991791004009 5-formyltetrahydrofolate cyclo-ligase [Coenzyme metabolism]; Region: COG0212 991791004010 5-formyltetrahydrofolate cyclo-ligase family; Region: 5-FTHF_cyc-lig; pfam01812 991791004011 M18 Peptidase Aminopeptidase I; Region: M18_API; cd05659 991791004012 Aminopeptidase I zinc metalloprotease (M18); Region: Peptidase_M18; pfam02127 991791004013 oligomer interface [polypeptide binding]; other site 991791004014 putative active site [active] 991791004015 metal binding site [ion binding]; metal-binding site 991791004016 Predicted metal-dependent phosphoesterases (PHP family) [General function prediction only]; Region: COG0613 991791004017 Polymerase and Histidinol Phosphatase domain of Histidinol phosphate phosphatase (HisPPase) AMP bound; Region: PHP_HisPPase_AMP; cd07438 991791004018 active site 991791004019 Polymerase and Histidinol Phosphatase domain; Region: PHP; cl17102 991791004020 Predicted Co/Zn/Cd cation transporters [Inorganic ion transport and metabolism]; Region: MMT1; COG0053 991791004021 Cation efflux family; Region: Cation_efflux; pfam01545 991791004022 Predicted membrane protein [Function unknown]; Region: COG2733 991791004023 Predicted membrane protein [Function unknown]; Region: COG2733 991791004024 DNA polymerase I; Provisional; Region: PRK05755 991791004025 PIN domain of the 5'-3' exonuclease of Taq DNA polymerase I and homologs; Region: PIN_53EXO; cd09859 991791004026 active site 991791004027 metal binding site 1 [ion binding]; metal-binding site 991791004028 putative 5' ssDNA interaction site; other site 991791004029 metal binding site 3; metal-binding site 991791004030 metal binding site 2 [ion binding]; metal-binding site 991791004031 H3TH domain of the 5'-3' exonuclease of Taq DNA polymerase I and homologs; Region: H3TH_53EXO; cd09898 991791004032 putative DNA binding site [nucleotide binding]; other site 991791004033 putative metal binding site [ion binding]; other site 991791004034 inactive DEDDy 3'-5' exonuclease domain of Bacillus stearothermophilus DNA polymerase I and similar family-A DNA polymerases; Region: DNA_polA_I_Bacillus_like_exo; cd06140 991791004035 Polymerase I functions primarily to fill DNA gaps that arise during DNA repair, recombination and replication; Region: DNA_pol_A_pol_I_C; cd08637 991791004036 active site 991791004037 DNA binding site [nucleotide binding] 991791004038 catalytic site [active] 991791004039 Dephospho-CoA kinase [Coenzyme metabolism]; Region: CoaE; COG0237 991791004040 Dephospho-coenzyme A kinase (DPCK, EC 2.7.1.24) catalyzes the phosphorylation of dephosphocoenzyme A (dCoA) to yield CoA, which is the final step in CoA biosynthesis; Region: DPCK; cd02022 991791004041 CoA-binding site [chemical binding]; other site 991791004042 Soluble lytic murein transglycosylase and related regulatory proteins (some contain LysM/invasin domains) [Cell envelope biogenesis, outer membrane]; Region: MltE; COG0741 991791004043 Lytic Transglycosylase (LT) and Goose Egg White Lysozyme (GEWL) domain. Members include the soluble and insoluble membrane-bound LTs in bacteria, the LTs in bacteriophage lambda, as well as, the eukaryotic "goose-type" lysozymes (GEWL). LTs...; Region: LT_GEWL; cd00254 991791004044 N-acetyl-D-glucosamine binding site [chemical binding]; other site 991791004045 catalytic residue [active] 991791004046 Recombinase zinc beta ribbon domain; Region: Zn_ribbon_recom; pfam13408 991791004047 Spc7 kinetochore protein; Region: Spc7; smart00787 991791004048 Endo-N-acetylmuramidases (muramidases) are lysozymes (also referred to as peptidoglycan hydrolases) that degrade bacterial cell walls by catalyzing the hydrolysis of 1,4-beta-linkages between N-acetylmuramic acid and N-acetyl-D-glucosamine residues; Region: GH25_muramidase; cl10448 991791004049 Glycosyl hydrolases family 25; Region: Glyco_hydro_25; pfam01183 991791004050 active site 991791004051 Putative peptidoglycan-binding domain-containing protein [Cell envelope biogenesis, outer membrane]; Region: COG3409 991791004052 Putative peptidoglycan binding domain; Region: PG_binding_1; pfam01471 991791004053 Haemolysin XhlA; Region: XhlA; pfam10779 991791004054 Phage integrase, N-terminal SAM-like domain; Region: Phage_integr_N2; pfam13495 991791004055 tyrosine recombinase XerD; Region: recomb_XerD; TIGR02225 991791004056 DNA breaking-rejoining enzymes, intergrase/recombinases, C-terminal catalytic domain. The tyrosine recombinase/integrase family share the same catalytic domain containing six conserved active site residues. The best-studied members of this diverse family...; Region: INT_REC_C; cd01182 991791004057 active site 991791004058 catalytic residues [active] 991791004059 DNA binding site [nucleotide binding] 991791004060 Int/Topo IB signature motif; other site 991791004061 Phage protein (N4 Gp49/phage Sf6 gene 66) family; Region: Phage_gp49_66; cl10351 991791004062 F5/8 type C domain; Region: F5_F8_type_C; pfam00754 991791004063 Chaperone of endosialidase; Region: Peptidase_S74; pfam13884 991791004064 phage tail tape measure protein, TP901 family, core region; Region: tape_meas_TP901; TIGR01760 991791004065 Lytic Transglycosylase (LT) and Goose Egg White Lysozyme (GEWL) domain. Members include the soluble and insoluble membrane-bound LTs in bacteria, the LTs in bacteriophage lambda, as well as, the eukaryotic "goose-type" lysozymes (GEWL). LTs...; Region: LT_GEWL; cd00254 991791004066 N-acetyl-D-glucosamine binding site [chemical binding]; other site 991791004067 catalytic residue [active] 991791004068 Bacterial Ig-like domain; Region: Big_5; pfam13205 991791004069 large terminase protein; Provisional; Region: 17; PHA02533 991791004070 Terminase-like family; Region: Terminase_6; pfam03237 991791004071 RNA dependent RNA polymerase; Region: RdRP; pfam05183 991791004072 Superfamily I DNA and RNA helicases [DNA replication, recombination, and repair]; Region: UvrD; COG0210 991791004073 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 991791004074 ATP binding site [chemical binding]; other site 991791004075 Family description; Region: UvrD_C_2; pfam13538 991791004076 ATP-dependent exoDNAse (exonuclease V), alpha subunit - helicase superfamily I member [DNA replication, recombination, and repair]; Region: RecD; COG0507 991791004077 AAA domain; Region: AAA_30; pfam13604 991791004078 Family description; Region: UvrD_C_2; pfam13538 991791004079 Domain of unknown function (DUF4121); Region: DUF4121; pfam13497 991791004080 Plasmid segregation protein ParM and similar proteins; Region: ParM_like; cd10227 991791004081 Mg binding site [ion binding]; other site 991791004082 nucleotide binding site [chemical binding]; other site 991791004083 putative protofilament interface [polypeptide binding]; other site 991791004084 Protein of unknown function DUF262; Region: DUF262; pfam03235 991791004085 Uncharacterized conserved protein [Function unknown]; Region: COG1479 991791004086 site-specific tyrosine recombinase XerC; Reviewed; Region: xerC; PRK00236 991791004087 DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213 991791004088 active site 991791004089 DNA binding site [nucleotide binding] 991791004090 Int/Topo IB signature motif; other site 991791004091 Replication protein A, class 2b aminoacyl-tRNA synthetases, and related proteins with oligonucleotide/oligosaccharide (OB) fold; Region: RPA_2b-aaRSs_OBF_like; cl09930 991791004092 generic binding surface II; other site 991791004093 AAA domain; Region: AAA_24; pfam13479 991791004094 3D domain; Region: 3D; cl01439 991791004095 Predicted Fe-S-cluster redox enzyme [General function prediction only]; Region: COG0820 991791004096 Replicative DNA helicase [DNA replication, recombination, and repair]; Region: DnaB; COG0305 991791004097 NAD-dependent DNA ligase LigA; Validated; Region: ligA; PRK07956 991791004098 NAD+ dependent DNA ligase adenylation domain. DNA ligases catalyze the crucial step of joining the breaks in duplex DNA during DNA replication, repair and recombination, utilizing either ATP or NAD(+) as a cofactor, but using the same basic reaction...; Region: LIGANc; cd00114 991791004099 nucleotide binding pocket [chemical binding]; other site 991791004100 K-X-D-G motif; other site 991791004101 catalytic site [active] 991791004102 NAD-dependent DNA ligase OB-fold domain; Region: DNA_ligase_OB; pfam03120 991791004103 NAD-dependent DNA ligase C4 zinc finger domain; Region: DNA_ligase_ZBD; pfam03119 991791004104 Breast Cancer Suppressor Protein (BRCA1), carboxy-terminal domain. The BRCT domain is found within many DNA damage repair and cell cycle checkpoint proteins. The unique diversity of this domain superfamily allows BRCT modules to interact forming homo...; Region: BRCT; cd00027 991791004105 Dimer interface [polypeptide binding]; other site 991791004106 BRCT sequence motif; other site 991791004107 hypothetical protein; Provisional; Region: PRK08624 991791004108 DNA primase catalytic core, N-terminal domain; Region: Toprim_N; pfam08275 991791004109 TOPRIM_DnaG_primases: The topoisomerase-primase (TORPIM) nucleotidyl transferase/hydrolase domain found in the active site regions of proteins similar to Escherichia coli DnaG. Primases synthesize RNA primers for the initiation of DNA replication. DnaG...; Region: TOPRIM_DnaG_primases; cd03364 991791004110 interdomain interaction site; other site 991791004111 active site 991791004112 metal binding site [ion binding]; metal-binding site 991791004113 single-stranded-DNA-specific exonuclease RecJ; Region: recJ; TIGR00644 991791004114 DHH family; Region: DHH; pfam01368 991791004115 DHHA1 domain; Region: DHHA1; pfam02272 991791004116 3'-phosphoadenosine 5'-phosphosulfate sulfotransferase (PAPS reductase)/FAD synthetase and related enzymes [Amino acid transport and metabolism / Coenzyme metabolism]; Region: CysH; COG0175 991791004117 This domain is found in phosphoadenosine phosphosulphate (PAPS) reductase enzymes or PAPS sulphotransferase. PAPS reductase is part of the adenine nucleotide alpha hydrolases superfamily also including N type ATP PPases and ATP sulphurylases. A highly...; Region: PAPS_reductase; cd01713 991791004118 Active Sites [active] 991791004119 GIY-YIG domain of uncharacterized hypothetical protein found in phycodnavirus PBCV-1 DNA virus, T. thermophila Tlr element eoncoding protein Tlr8p, and similar proteins found in bacteria; Region: GIY-YIG_HE_Tlr8p_PBC-V_like; cd10443 991791004120 GIY-YIG motif/motif A; other site 991791004121 putative active site [active] 991791004122 putative metal binding site [ion binding]; other site 991791004123 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4728 991791004124 anaerobic ribonucleoside triphosphate reductase; Provisional; Region: PRK07111 991791004125 ATP cone domain; Region: ATP-cone; pfam03477 991791004126 Class III ribonucleotide reductase; Region: RNR_III; cd01675 991791004127 effector binding site; other site 991791004128 active site 991791004129 Zn binding site [ion binding]; other site 991791004130 glycine loop; other site 991791004131 Trimeric dUTP diphosphatases; Region: trimeric_dUTPase; cd07557 991791004132 trimer interface [polypeptide binding]; other site 991791004133 active site 991791004134 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 991791004135 non-specific DNA binding site [nucleotide binding]; other site 991791004136 salt bridge; other site 991791004137 sequence-specific DNA binding site [nucleotide binding]; other site 991791004138 Tetratricopeptide repeat; Region: TPR_12; pfam13424 991791004139 Guanylate kinase [Nucleotide transport and metabolism]; Region: Gmk; COG0194 991791004140 Nucleoside/nucleotide kinase (NK) is a protein superfamily consisting of multiple families of enzymes that share structural similarity and are functionally related to the catalysis of the reversible phosphate group transfer from nucleoside triphosphates...; Region: NK; cl17190 991791004141 active site 991791004142 5'(3')-deoxyribonucleotidase [Nucleotide transport and metabolism]; Region: COG4502 991791004143 Site-specific DNA methylase [DNA replication, recombination, and repair]; Region: Dcm; COG0270 991791004144 Cytosine-C5 specific DNA methylases; Methyl transfer reactions play an important role in many aspects of biology. Cytosine-specific DNA methylases are found both in prokaryotes and eukaryotes. DNA methylation, or the covalent addition of a methyl group...; Region: Cyt_C5_DNA_methylase; cd00315 991791004145 cofactor binding site; other site 991791004146 DNA binding site [nucleotide binding] 991791004147 substrate interaction site [chemical binding]; other site 991791004148 DNA polymerase III, alpha subunit [DNA replication, recombination, and repair]; Region: DnaE; COG0587 991791004149 Polymerase and Histidinol Phosphatase domain; Region: PHP; cl17102 991791004150 active site 991791004151 DnaE_OBF: A subfamily of OB folds corresponding to the C-terminal OB-fold nucleic acid binding domain of Thermus aquaticus and Escherichia coli type C replicative DNA polymerase III alpha subunit (DnaE). The DNA polymerase holoenzyme of E. coli contains...; Region: DnaE_OBF; cd04485 991791004152 generic binding surface II; other site 991791004153 generic binding surface I; other site 991791004154 DNA-directed RNA polymerase specialized sigma subunit [Transcription]; Region: FliA; COG1191 991791004155 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 991791004156 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cl17257 991791004157 DNA binding residues [nucleotide binding] 991791004158 Site-specific recombinases, DNA invertase Pin homologs [DNA replication, recombination, and repair]; Region: PinR; COG1961 991791004159 Serine Recombinase (SR) family, TndX-like transposase subfamily, catalytic domain; composed of large serine recombinases similar to Clostridium TndX and TnpX transposases. Serine recombinases catalyze site-specific recombination of DNA molecules by a...; Region: SR_TndX_transposase; cd03770 991791004160 putative catalytic residues [active] 991791004161 catalytic nucleophile [active] 991791004162 Recombinase; Region: Recombinase; pfam07508 991791004163 Recombinase zinc beta ribbon domain; Region: Zn_ribbon_recom; pfam13408 991791004164 Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673 991791004165 Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408 991791004166 Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118 991791004167 Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118 991791004168 Cell wall hydrolyses involved in spore germination [Cell envelope biogenesis, outer membrane]; Region: SleB; COG3773 991791004169 Cell Wall Hydrolase; Region: Hydrolase_2; pfam07486 991791004170 Chemotaxis signal transduction protein [Cell motility and secretion / Signal transduction mechanisms]; Region: CheW; COG0835 991791004171 FOG: CheY-like receiver [Signal transduction mechanisms]; Region: CheY; COG0784 991791004172 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 991791004173 active site 991791004174 phosphorylation site [posttranslational modification] 991791004175 intermolecular recognition site; other site 991791004176 dimerization interface [polypeptide binding]; other site 991791004177 hypothetical protein; Provisional; Region: PRK04435 991791004178 C-terminal ACT domain of a small (; 147 a.a.) putative phenylalanine biosynthetic pathway protein described in Bacillus subtilis (BS) PheB (PheB-BS) and related domains; Region: ACT_PheB-BS; cd04888 991791004179 Homoserine kinase [Amino acid transport and metabolism]; Region: ThrB; COG0083 991791004180 GHMP kinases N terminal domain; Region: GHMP_kinases_N; pfam00288 991791004181 Acetyltransferase (GNAT) domain; Region: Acetyltransf_4; pfam13420 991791004182 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl17182 991791004183 Domain of unknown function (DUF4321); Region: DUF4321; pfam14209 991791004184 Maf-like protein; Reviewed; Region: PRK00078 991791004185 Nucleotide binding protein Maf. Maf has been implicated in inhibition of septum formation in eukaryotes, bacteria and archaea, but homologs in B.subtilis and S.cerevisiae are nonessential for cell division. Maf has been predicted to be a nucleotide- or...; Region: Maf; cd00555 991791004186 active site 991791004187 dimer interface [polypeptide binding]; other site 991791004188 hypothetical protein; Reviewed; Region: PRK00024 991791004189 Mov34/MPN/PAD-1 family; Region: MPN_DUF2466; cd08071 991791004190 MPN+ (JAMM) motif; other site 991791004191 Zinc-binding site [ion binding]; other site 991791004192 rod shape-determining protein MreB; Provisional; Region: PRK13927 991791004193 MreB and similar proteins; Region: MreB_like; cd10225 991791004194 nucleotide binding site [chemical binding]; other site 991791004195 Mg binding site [ion binding]; other site 991791004196 putative protofilament interaction site [polypeptide binding]; other site 991791004197 RodZ interaction site [polypeptide binding]; other site 991791004198 Cell shape-determining protein [Cell envelope biogenesis, outer membrane]; Region: MreC; COG1792 991791004199 rod shape-determining protein MreC; Region: MreC; pfam04085 991791004200 rod shape-determining protein MreD; Region: MreD; pfam04093 991791004201 Penicillin-binding Protein dimerisation domain; Region: PBP_dimer; pfam03717 991791004202 Penicillin-binding Protein dimerisation domain; Region: PBP_dimer; pfam03717 991791004203 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; cl17760 991791004204 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; cl17760 991791004205 Penicillin-binding Protein dimerisation domain; Region: PBP_dimer; pfam03717 991791004206 Penicillin-binding Protein dimerisation domain; Region: PBP_dimer; pfam03717 991791004207 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; cl17760 991791004208 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; cl17760 991791004209 Penicillin-binding Protein dimerisation domain; Region: PBP_dimer; pfam03717 991791004210 Penicillin-binding Protein dimerisation domain; Region: PBP_dimer; pfam03717 991791004211 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; cl17760 991791004212 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; cl17760 991791004213 septum formation inhibitor; Reviewed; Region: minC; PRK00513 991791004214 Septum formation inhibitor MinC, C-terminal domain; Region: MinC_C; pfam03775 991791004215 septum site-determining protein MinD; Region: minD_bact; TIGR01968 991791004216 Bacterial cell division requires the formation of a septum at mid-cell. The site is determined by the min operon products MinC, MinD and MinE. MinC is a nonspecific inhibitor of the septum protein FtsZ. MinE is the supressor of MinC. MinD plays a pivotal...; Region: MinD; cd02036 991791004217 Switch I; other site 991791004218 Switch II; other site 991791004219 cell division topological specificity factor MinE; Provisional; Region: PRK13987 991791004220 rod shape-determining protein RodA; Region: rodA_shape; TIGR02210 991791004221 Membrane proteins related to metalloendopeptidases [Cell envelope biogenesis, outer membrane]; Region: NlpD; COG0739 991791004222 Peptidase family M23; Region: Peptidase_M23; pfam01551 991791004223 SpoIVFB Site-2 protease (S2P), a zinc metalloprotease (MEROPS family M50B), regulates intramembrane proteolysis (RIP), and is involved in the pro-sigmaK pathway of bacterial spore formation. SpoIVFB (sporulation protein, stage IV cell wall formation, F...; Region: S2P-M50_SpoIVFB; cd06161 991791004224 Peptidase family M50; Region: Peptidase_M50; pfam02163 991791004225 active site 991791004226 putative substrate binding region [chemical binding]; other site 991791004227 The CBS domain, named after human CBS, is a small domain originally identified in cystathionine beta-synthase and is subsequently found in a wide range of different proteins. CBS domains usually occur in tandem repeats. They associate to form a so-called...; Region: CBS_pair; cl15354 991791004228 radical SAM family uncharacterized protein; Region: rSAM_fuse_unch; TIGR03960 991791004229 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 991791004230 FeS/SAM binding site; other site 991791004231 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG5011 991791004232 radical SAM-linked protein; Region: sam_1_link_chp; TIGR03936 991791004233 Ribonucleases G and E [Translation, ribosomal structure and biogenesis]; Region: CafA; COG1530 991791004234 S1_RNase_E: RNase E and RNase G, S1-like RNA-binding domain. RNase E is an essential endoribonuclease in the processing and degradation of RNA. In addition to its role in mRNA degradation, RNase E has also been implicated in the processing of rRNA, and...; Region: S1_RNase_E; cd04453 991791004235 homodimer interface [polypeptide binding]; other site 991791004236 oligonucleotide binding site [chemical binding]; other site 991791004237 50S ribosomal protein L21; Validated; Region: rplU; PRK05573 991791004238 Predicted ribosomal protein [Translation, ribosomal structure and biogenesis]; Region: COG2868 991791004239 50S ribosomal protein L27; Validated; Region: rpmA; PRK05435 991791004240 GTPase CgtA; Reviewed; Region: obgE; PRK12297 991791004241 GTP1/OBG; Region: GTP1_OBG; pfam01018 991791004242 Obg GTPase; Region: Obg; cd01898 991791004243 G1 box; other site 991791004244 GTP/Mg2+ binding site [chemical binding]; other site 991791004245 Switch I region; other site 991791004246 G2 box; other site 991791004247 G3 box; other site 991791004248 Switch II region; other site 991791004249 G4 box; other site 991791004250 G5 box; other site 991791004251 Domain of unknown function (DUF1967); Region: DUF1967; pfam09269 991791004252 Predicted RNA-binding protein containing KH domain, possibly ribosomal protein [Translation, ribosomal structure and biogenesis]; Region: COG1534 991791004253 nicotinic acid mononucleotide adenylyltransferase; Provisional; Region: nadD; PRK00071 991791004254 Nicotinamide/nicotinate mononucleotide adenylyltransferase; Region: NMNAT; cd02165 991791004255 active site 991791004256 (T/H)XGH motif; other site 991791004257 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 991791004258 Zn2+ binding site [ion binding]; other site 991791004259 Mg2+ binding site [ion binding]; other site 991791004260 Transcriptional regulator [Transcription]; Region: LytR; COG1316 991791004261 LytR cell envelope-related transcriptional attenuator; Region: LytR_C; pfam13399 991791004262 YjgF, YER057c, and UK114 belong to a large family of proteins present in bacteria, archaea, and eukaryotes with no definitive function. The conserved domain is similar in structure to chorismate mutase but there is no sequence similarity and no...; Region: YjgF_YER057c_UK114_family; cd00448 991791004263 homotrimer interaction site [polypeptide binding]; other site 991791004264 putative active site [active] 991791004265 Pseudouridylate synthases, 23S RNA-specific [Translation, ribosomal structure and biogenesis]; Region: RluA; COG0564 991791004266 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cl09940 991791004267 RNA binding surface [nucleotide binding]; other site 991791004268 Pseudouridine synthase, RsuA/RluD family; Region: PseudoU_synth_RluCD_like; cd02869 991791004269 active site 991791004270 D-alanyl-D-alanine carboxypeptidase [Cell envelope biogenesis, outer membrane]; Region: DacC; COG1686 991791004271 Beta-lactamase enzyme family; Region: Beta-lactamase2; cl17872 991791004272 Penicillin-binding protein 5, C-terminal domain; Region: PBP5_C; pfam07943 991791004273 SLBB domain; Region: SLBB; pfam10531 991791004274 comEA protein; Region: comE; TIGR01259 991791004275 Cation transporter/ATPase, N-terminus; Region: Cation_ATPase_N; smart00831 991791004276 Cation transport ATPase [Inorganic ion transport and metabolism]; Region: MgtA; COG0474 991791004277 E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122 991791004278 Putative hydrolase of sodium-potassium ATPase alpha subunit; Region: Hydrolase_like2; pfam13246 991791004279 Predicted membrane metal-binding protein [General function prediction only]; Region: ComEC; COG0658 991791004280 Competence protein; Region: Competence; pfam03772 991791004281 DNA polymerase III subunit delta; Reviewed; Region: holA; PRK05574 991791004282 DNA polymerase III, delta subunit; Region: DNA_pol3_delta; pfam06144 991791004283 30S ribosomal protein S20; Reviewed; Region: rpsT; PRK00239 991791004284 GPR endopeptidase; Region: GPR; TIGR01441 991791004285 Stage II sporulation protein P (SpoIIP); Region: SpoIIP; pfam07454 991791004286 stage II sporulation protein P; Region: spore_II_P; TIGR02867 991791004287 GTP-binding protein LepA; Provisional; Region: PRK05433 991791004288 LepA also known as Elongation Factor 4 (EF4); Region: LepA; cd01890 991791004289 G1 box; other site 991791004290 putative GEF interaction site [polypeptide binding]; other site 991791004291 GTP/Mg2+ binding site [chemical binding]; other site 991791004292 Switch I region; other site 991791004293 G2 box; other site 991791004294 G3 box; other site 991791004295 Switch II region; other site 991791004296 G4 box; other site 991791004297 G5 box; other site 991791004298 lepA_II: This subfamily represents the domain II of LepA, a GTP-binding protein localized in the cytoplasmic membrane. The N-terminal domain of LepA shares regions of homology to translation factors. In terms of interaction with the ribosome, EF-G, EF-Tu...; Region: lepA_II; cd03699 991791004299 lepA_C: This family represents the C-terminal region of LepA, a GTP-binding protein localized in the cytoplasmic membrane. LepA is ubiquitous in Bacteria and Eukaryota (e.g. Saccharomyces cerevisiae GUF1p), but is missing from Archaea. LepA exhibits...; Region: lepA_C; cd03709 991791004300 GTP-binding protein LepA C-terminus; Region: LepA_C; pfam06421 991791004301 coproporphyrinogen III oxidase; Provisional; Region: PRK05799 991791004302 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 991791004303 FeS/SAM binding site; other site 991791004304 HemN C-terminal domain; Region: HemN_C; pfam06969 991791004305 heat shock gene repressor HrcA; Region: hrcA; TIGR00331 991791004306 Winged helix-turn-helix transcription repressor, HrcA DNA-binding; Region: HrcA_DNA-bdg; pfam03444 991791004307 GrpE; Region: GrpE; pfam01025 991791004308 GrpE is the adenine nucleotide exchange factor of DnaK (Hsp70)-type ATPases. The GrpE dimer binds to the ATPase domain of Hsp70 catalyzing the dissociation of ADP, which enables rebinding of ATP, one step in the Hsp70 reaction cycle in protein folding; Region: GrpE; cd00446 991791004309 dimer interface [polypeptide binding]; other site 991791004310 hsp70 (ATPase domain) interactions [polypeptide binding]; other site 991791004311 molecular chaperone DnaK; Provisional; Region: dnaK; PRK00290 991791004312 Nucleotide-binding domain of human HSPA9 and similar proteins; Region: HSPA9-Ssq1-like_NBD; cd10234 991791004313 nucleotide binding site [chemical binding]; other site 991791004314 NEF interaction site [polypeptide binding]; other site 991791004315 SBD interface [polypeptide binding]; other site 991791004316 chaperone protein DnaJ; Provisional; Region: PRK14297 991791004317 DnaJ domain or J-domain. DnaJ/Hsp40 (heat shock protein 40) proteins are highly conserved and play crucial roles in protein translation, folding, unfolding, translocation, and degradation. They act primarily by stimulating the ATPase activity of Hsp70s; Region: DnaJ; cd06257 991791004318 HSP70 interaction site [polypeptide binding]; other site 991791004319 C-terminal substrate binding domain of DnaJ and HSP40; Region: DnaJ_C; cd10747 991791004320 substrate binding site [polypeptide binding]; other site 991791004321 dimer interface [polypeptide binding]; other site 991791004322 Ribosomal protein L11 methyltransferase (PrmA); Region: PrmA; pfam06325 991791004323 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 991791004324 S-adenosylmethionine binding site [chemical binding]; other site 991791004325 RNA methyltransferase, RsmE family; Region: TIGR00046 991791004326 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG1385 991791004327 2-methylthioadenine synthetase [Translation, ribosomal structure and biogenesis]; Region: MiaB; COG0621 991791004328 Uncharacterized protein family UPF0004; Region: UPF0004; pfam00919 991791004329 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 991791004330 FeS/SAM binding site; other site 991791004331 Protein Kinase C Interacting protein related (PKCI): PKCI and related proteins belong to the ubiquitous HIT family of hydrolases that act on alpha-phosphates of ribonucleotides. The members of this subgroup have a conserved HxHxHxx motif (x is a...; Region: PKCI_related; cd01276 991791004332 nucleotide binding site/active site [active] 991791004333 HIT family signature motif; other site 991791004334 catalytic residue [active] 991791004335 30S ribosomal protein S21; Reviewed; Region: rpsU; PRK00270 991791004336 Yqey-like protein; Region: YqeY; pfam09424 991791004337 sporulation protein YqfC; Region: spore_yqfC; TIGR02856 991791004338 Putative stage IV sporulation protein YqfD; Region: YqfD; pfam06898 991791004339 sporulation protein YqfD; Region: spore_yqfD; TIGR02876 991791004340 Predicted membrane-associated HD superfamily hydrolase [General function prediction only]; Region: COG1480 991791004341 7TM receptor with intracellular HD hydrolase; Region: 7TM-7TMR_HD; pfam07698 991791004342 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 991791004343 Zn2+ binding site [ion binding]; other site 991791004344 Mg2+ binding site [ion binding]; other site 991791004345 metal-binding heat shock protein; Provisional; Region: PRK00016 991791004346 Diacylglycerol kinase [Cell envelope biogenesis, outer membrane]; Region: DgkA; COG0818 991791004347 PAP2_like proteins, diacylglycerol_kinase like sub-family. In some prokaryotes, PAP2_like phosphatase domains appear fused to E. coli DAGK-like trans-membrane diacylglycerol kinase domains. The cellular function of these architectures remains to be...; Region: PAP2_diacylglycerolkinase; cd03383 991791004348 Membrane-associated phospholipid phosphatase [Lipid metabolism]; Region: PgpB; COG0671 991791004349 active site 991791004350 GTPase Era; Reviewed; Region: era; PRK00089 991791004351 E. coli Ras-like protein (Era) is a multifunctional GTPase; Region: Era; cd04163 991791004352 G1 box; other site 991791004353 GTP/Mg2+ binding site [chemical binding]; other site 991791004354 Switch I region; other site 991791004355 G2 box; other site 991791004356 Switch II region; other site 991791004357 G3 box; other site 991791004358 G4 box; other site 991791004359 G5 box; other site 991791004360 KH domain; Region: KH_2; pfam07650 991791004361 DNA repair protein RecO; Region: reco; TIGR00613 991791004362 Recombination protein O N terminal; Region: RecO_N; pfam11967 991791004363 Recombination protein O C terminal; Region: RecO_C; pfam02565 991791004364 Domain of unknown function (DUF4342); Region: DUF4342; pfam14242 991791004365 spore coat protein YsxE; Region: spore_ysxE; TIGR02904 991791004366 spore coat protein, CotS family; Region: spore_CotS; TIGR02906 991791004367 DNA primase; Validated; Region: dnaG; PRK05667 991791004368 CHC2 zinc finger; Region: zf-CHC2; pfam01807 991791004369 DNA primase catalytic core, N-terminal domain; Region: Toprim_N; pfam08275 991791004370 TOPRIM_DnaG_primases: The topoisomerase-primase (TORPIM) nucleotidyl transferase/hydrolase domain found in the active site regions of proteins similar to Escherichia coli DnaG. Primases synthesize RNA primers for the initiation of DNA replication. DnaG...; Region: TOPRIM_DnaG_primases; cd03364 991791004371 active site 991791004372 metal binding site [ion binding]; metal-binding site 991791004373 interdomain interaction site; other site 991791004374 DnaB-helicase binding domain of primase; Region: DnaB_bind; pfam10410 991791004375 RNA polymerase sigma factor RpoD; Validated; Region: PRK09210 991791004376 Sigma-70 factor, region 1.1; Region: Sigma70_r1_1; pfam03979 991791004377 Sigma-70 factor, region 1.2; Region: Sigma70_r1_2; pfam00140 991791004378 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 991791004379 Sigma-70 region 3; Region: Sigma70_r3; pfam04539 991791004380 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 991791004381 DNA binding residues [nucleotide binding] 991791004382 Protein of unknown function (DUF2679); Region: DUF2679; pfam10882 991791004383 Predicted SAM-dependent methyltransferase [General function prediction only]; Region: COG2384 991791004384 Family of unknown function (DUF633); Region: DUF633; pfam04816 991791004385 Uncharacterized conserved protein [Function unknown]; Region: COG0327 991791004386 NIF3 (NGG1p interacting factor 3); Region: NIF3; pfam01784 991791004387 Zn-ribbon protein, possibly nucleic acid-binding [General function prediction only]; Region: COG1579 991791004388 Putative zinc ribbon domain; Region: DUF164; pfam02591 991791004389 Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805 991791004390 Pentapeptide repeats (9 copies); Region: Pentapeptide_4; pfam13599 991791004391 Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805 991791004392 Pentapeptide repeats (9 copies); Region: Pentapeptide_4; pfam13599 991791004393 DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213 991791004394 DNA binding site [nucleotide binding] 991791004395 Int/Topo IB signature motif; other site 991791004396 active site 991791004397 Protein of unknown function (DUF3467); Region: DUF3467; pfam11950 991791004398 Putative peptidoglycan-binding domain-containing protein [Cell envelope biogenesis, outer membrane]; Region: COG3409 991791004399 Putative peptidoglycan binding domain; Region: PG_binding_1; pfam01471 991791004400 Kef-type K+ transport systems, predicted NAD-binding component [Inorganic ion transport and metabolism]; Region: Kch; COG1226 991791004401 Ion channel; Region: Ion_trans_2; pfam07885 991791004402 Glycerol uptake facilitator and related permeases (Major Intrinsic Protein Family) [Carbohydrate transport and metabolism]; Region: GlpF; COG0580 991791004403 amphipathic channel; other site 991791004404 Asn-Pro-Ala signature motifs; other site 991791004405 Glycerol-3-phosphate responsive antiterminator (mRNA-binding) [Transcription]; Region: GlpP; COG1954 991791004406 glycerol kinase; Provisional; Region: glpK; PRK00047 991791004407 Escherichia coli glycerol kinase-like proteins; belongs to the FGGY family of carbohydrate kinases; Region: FGGY_EcGK_like; cd07786 991791004408 N- and C-terminal domain interface [polypeptide binding]; other site 991791004409 active site 991791004410 MgATP binding site [chemical binding]; other site 991791004411 catalytic site [active] 991791004412 metal binding site [ion binding]; metal-binding site 991791004413 glycerol binding site [chemical binding]; other site 991791004414 homotetramer interface [polypeptide binding]; other site 991791004415 homodimer interface [polypeptide binding]; other site 991791004416 FBP binding site [chemical binding]; other site 991791004417 protein IIAGlc interface [polypeptide binding]; other site 991791004418 Predicted dehydrogenase [General function prediction only]; Region: COG0579 991791004419 hydroxyglutarate oxidase; Provisional; Region: PRK11728 991791004420 BFD-like [2Fe-2S] binding domain; Region: Fer2_BFD; pfam04324 991791004421 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500 991791004422 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox_2; pfam07992 991791004423 Uncharacterized protein with conserved CXXC pairs [Function unknown]; Region: COG3862 991791004424 Uncharacterized conserved protein [Function unknown]; Region: COG1284 991791004425 Uncharacterized BCR, YitT family COG1284; Region: DUF161; pfam02588 991791004426 Uncharacterized protein conserved in bacteria (DUF2179); Region: DUF2179; pfam10035 991791004427 putative iron-only hydrogenase system regulator; Region: hyd_TM1266; TIGR03959 991791004428 Spo0E like sporulation regulatory protein; Region: SpoOE-like; pfam09388 991791004429 Predicted thioesterase involved in non-ribosomal peptide biosynthesis [Secondary metabolites biosynthesis, transport, and catabolism]; Region: GrsT; COG3208 991791004430 Phosphopantetheinyl transferase [Coenzyme metabolism]; Region: Sfp; COG2091 991791004431 4'-phosphopantetheinyl transferase superfamily; Region: ACPS; pfam01648 991791004432 Metal-dependent hydrolases of the beta-lactamase superfamily III [General function prediction only]; Region: ElaC; COG1234 991791004433 D-mannonate oxidoreductase; Provisional; Region: PRK08277 991791004434 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 991791004435 NAD(P) binding site [chemical binding]; other site 991791004436 active site 991791004437 mannonate dehydratase; Provisional; Region: PRK03906 991791004438 mannonate dehydratase; Region: uxuA; TIGR00695 991791004439 AraC-like ligand binding domain; Region: AraC_binding; pfam02311 991791004440 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 991791004441 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 991791004442 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 991791004443 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 991791004444 Radical SAM superfamily; Region: Radical_SAM; pfam04055 991791004445 FeS/SAM binding site; other site 991791004446 Domain of unknown function (DUF4008); Region: DUF4008; pfam13186 991791004447 Spore coat protein [Cell envelope biogenesis, outer membrane]; Region: COG5577 991791004448 Spore coat associated protein JA (CotJA); Region: CotJA; pfam11007 991791004449 CotJB protein; Region: CotJB; pfam12652 991791004450 Manganese catalase, ferritin-like diiron-binding domain; Region: Mn_catalase; cd01051 991791004451 dimanganese center [ion binding]; other site 991791004452 D-xylose transporter XylE; Provisional; Region: xylE; PRK10077 991791004453 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 991791004454 putative substrate translocation pore; other site 991791004455 Transcriptional regulators [Transcription]; Region: PhnF; COG2188 991791004456 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 991791004457 DNA-binding site [nucleotide binding]; DNA binding site 991791004458 Transcriptional regulators [Transcription]; Region: PurR; COG1609 991791004459 Ligand-binding domain of DNA transcription repressor specific for arabinose (AraR) which is a member of the LacI-GalR family of bacterial transcription regulators; Region: PBP1_AraR; cd01541 991791004460 putative dimerization interface [polypeptide binding]; other site 991791004461 putative ligand binding site [chemical binding]; other site 991791004462 L-ribulose-5-phosphate 4-epimerase; Reviewed; Region: araD; PRK08193 991791004463 Class II Aldolase and Adducin head (N-terminal) domain. Aldolases are ubiquitous enzymes catalyzing central steps of carbohydrate metabolism. Based on enzymatic mechanisms, this superfamily has been divided into two distinct classes (Class I and II); Region: Aldolase_II; cd00398 991791004464 intersubunit interface [polypeptide binding]; other site 991791004465 active site 991791004466 Zn2+ binding site [ion binding]; other site 991791004467 L-arabinose isomerase; Provisional; Region: PRK02929 991791004468 L-fucose isomerase (FucIase) and L-arabinose isomerase (AI) family; composed of FucIase, AI and similar proteins. FucIase converts L-fucose, an aldohexose, to its ketose form, which prepares it for aldol cleavage (similar to the isomerization of glucose...; Region: L-fuc_L-ara-isomerases; cl00947 991791004469 hexamer (dimer of trimers) interface [polypeptide binding]; other site 991791004470 trimer interface [polypeptide binding]; other site 991791004471 substrate binding site [chemical binding]; other site 991791004472 Mn binding site [ion binding]; other site 991791004473 putative phosphoketolase; Provisional; Region: PRK05261 991791004474 Thiamine pyrophosphate (TPP) family, Phosphoketolase (PK) subfamily, TPP-binding module; PK catalyzes the conversion of D-xylulose 5-phosphate and phosphate to acetyl phosphate, D-glyceraldehyde-3-phosphate and H2O. This enzyme requires divalent...; Region: TPP_PK; cd02011 991791004475 TPP-binding site; other site 991791004476 XFP C-terminal domain; Region: XFP_C; pfam09363 991791004477 L-ribulokinase-like proteins; a subfamily of the FGGY family of carbohydrate kinases; Region: FGGY_L-RBK_like; cd07778 991791004478 Sugar (pentulose and hexulose) kinases [Carbohydrate transport and metabolism]; Region: XylB; COG1070 991791004479 putative N- and C-terminal domain interface [polypeptide binding]; other site 991791004480 putative active site [active] 991791004481 MgATP binding site [chemical binding]; other site 991791004482 catalytic site [active] 991791004483 metal binding site [ion binding]; metal-binding site 991791004484 putative carbohydrate binding site [chemical binding]; other site 991791004485 Sugar (and other) transporter; Region: Sugar_tr; pfam00083 991791004486 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 991791004487 putative substrate translocation pore; other site 991791004488 L-arabinose isomerase; Provisional; Region: PRK02929 991791004489 L-Arabinose isomerase (AI) catalyzes the isomerization of L-arabinose to L-ribulose, the first reaction in its conversion into D-xylulose-5-phosphate, an intermediate in the pentose phosphate pathway, which allows L-arabinose to be used as a carbon...; Region: L-arabinose_isomerase; cd03557 991791004490 putative hexamer (dimer of trimers) interface [polypeptide binding]; other site 991791004491 trimer interface [polypeptide binding]; other site 991791004492 putative substrate binding site [chemical binding]; other site 991791004493 putative metal binding site [ion binding]; other site 991791004494 Transaldolase-like fructose-6-phosphate aldolases (FSA) found in bacteria and archaea; Region: Transaldolase_FSA; cd00956 991791004495 active site 991791004496 intersubunit interactions; other site 991791004497 catalytic residue [active] 991791004498 Transketolase [Carbohydrate transport and metabolism]; Region: TktA; COG0021 991791004499 Thiamine pyrophosphate (TPP) family, Transketolase (TK) subfamily, TPP-binding module; TK catalyzes the transfer of a two-carbon unit from ketose phosphates to aldose phosphates. In heterotrophic organisms, TK provides a link between glycolysis and the...; Region: TPP_TK; cd02012 991791004500 TPP-binding site [chemical binding]; other site 991791004501 dimer interface [polypeptide binding]; other site 991791004502 Pyrimidine (PYR) binding domain of 1-deoxy-D-xylulose-5-phosphate synthase (DXS), transketolase (TK), and related proteins; Region: TPP_PYR_DXS_TK_like; cd07033 991791004503 PYR/PP interface [polypeptide binding]; other site 991791004504 dimer interface [polypeptide binding]; other site 991791004505 TPP binding site [chemical binding]; other site 991791004506 Transketolase, C-terminal domain; Region: Transketolase_C; pfam02780 991791004507 galactose mutarotase_like; Region: galactose_mutarotase_like; cd09019 991791004508 active site 991791004509 catalytic residues [active] 991791004510 YdcF-like. YdcF-like is a large family of mainly bacterial proteins, with a few members found in fungi, plants, and archaea. Escherichia coli YdcF has been shown to bind S-adenosyl-L-methionine (AdoMet), but a biochemical function has not been...; Region: YdcF-like; cl00630 991791004511 putative active site [active] 991791004512 ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: RbsB; COG1879 991791004513 Periplasmic binding proteins specific to rhizopines; Region: PBP1_rhizopine_binding_like; cd06301 991791004514 putative ligand binding site [chemical binding]; other site 991791004515 HAMP (Histidine kinases, Adenylyl cyclases, Methyl binding proteins, Phosphatases) domain; Region: HAMP; smart00304 991791004516 dimerization interface [polypeptide binding]; other site 991791004517 Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer); Region: MA; smart00283 991791004518 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 991791004519 dimer interface [polypeptide binding]; other site 991791004520 putative CheW interface [polypeptide binding]; other site 991791004521 Phosphotransferase system IIC components, glucose/maltose/N-acetylglucosamine-specific [Carbohydrate transport and metabolism]; Region: PtsG; COG1263 991791004522 PTS system, N-acetylglucosamine-specific IIBC component; Region: PTS-II-BC-nag; TIGR01998 991791004523 PTS_IIB, PTS system, glucose/sucrose specific IIB subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIB_glc; cd00212 991791004524 active site turn [active] 991791004525 phosphorylation site [posttranslational modification] 991791004526 Phosphotransferase system IIA components [Carbohydrate transport and metabolism]; Region: NagE; COG2190 991791004527 HPr interaction site; other site 991791004528 glycerol kinase (GK) interaction site [polypeptide binding]; other site 991791004529 active site 991791004530 phosphorylation site [posttranslational modification] 991791004531 transcriptional antiterminator BglG; Provisional; Region: PRK09772 991791004532 CAT RNA binding domain; Region: CAT_RBD; smart01061 991791004533 PRD domain; Region: PRD; pfam00874 991791004534 PRD domain; Region: PRD; pfam00874 991791004535 [FeFe] hydrogenase H-cluster radical SAM maturase HydG; Region: rSAM_HydG; TIGR03955 991791004536 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 991791004537 FeS/SAM binding site; other site 991791004538 Biotin and Thiamin Synthesis associated domain; Region: BATS; smart00876 991791004539 Predicted xylanase/chitin deacetylase [Carbohydrate transport and metabolism]; Region: CDA1; COG0726 991791004540 Catalytic NodB homology domain of Streptococcus mutans polysaccharide deacetylase PgdA, Bacillus subtilis YheN, and similar proteins; Region: CE4_SmPgdA_like; cd10944 991791004541 NodB motif; other site 991791004542 active site 991791004543 catalytic site [active] 991791004544 Zn binding site [ion binding]; other site 991791004545 Uncharacterized conserved protein [General function prediction only]; Region: BioY; COG1268 991791004546 AAA domain; Region: AAA_26; pfam13500 991791004547 dithiobiotin synthetase; Reviewed; Region: bioD; PRK00090 991791004548 Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610 991791004549 adenosylmethionine-8-amino-7-oxononanoate transaminase; Region: bioA; TIGR00508 991791004550 inhibitor-cofactor binding pocket; inhibition site 991791004551 pyridoxal 5'-phosphate binding site [chemical binding]; other site 991791004552 catalytic residue [active] 991791004553 Cu/Zn superoxide dismutase [Inorganic ion transport and metabolism]; Region: SodC; COG2032 991791004554 Copper/zinc superoxide dismutase (SOD). superoxide dismutases catalyse the conversion of superoxide radicals to molecular oxygen. Three evolutionarily distinct families of SODs are known, of which the copper/zinc-binding family is one. Defects in the...; Region: Cu-Zn_Superoxide_Dismutase; cd00305 991791004555 E-class dimer interface [polypeptide binding]; other site 991791004556 P-class dimer interface [polypeptide binding]; other site 991791004557 active site 991791004558 Cu2+ binding site [ion binding]; other site 991791004559 Zn2+ binding site [ion binding]; other site 991791004560 Catalytic domain of EDTA-resistant nuclease Nuc from Salmonella typhimurium and similar proteins; Region: PLDc_Nuc; cd09170 991791004561 PLD-like domain; Region: PLDc_2; pfam13091 991791004562 putative active site [active] 991791004563 catalytic site [active] 991791004564 cobalt transport protein CbiM; Validated; Region: PRK08319 991791004565 Cobalt uptake substrate-specific transmembrane region; Region: CbiM; pfam01891 991791004566 cobalt ABC transporter, permease protein CbiQ; Region: CbiQ_TIGR; TIGR02454 991791004567 cobalt transporter ATP-binding subunit; Provisional; Region: cbiO; PRK13639 991791004568 First domain of the ATP-binding cassette component of cobalt transport system; Region: ABC_cobalt_CbiO_domain1; cd03225 991791004569 Walker A/P-loop; other site 991791004570 ATP binding site [chemical binding]; other site 991791004571 Q-loop/lid; other site 991791004572 ABC transporter signature motif; other site 991791004573 Walker B; other site 991791004574 D-loop; other site 991791004575 H-loop/switch region; other site 991791004576 Histidinol-phosphate/aromatic aminotransferase and cobyric acid decarboxylase [Amino acid transport and metabolism]; Region: HisC; COG0079 991791004577 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 991791004578 pyridoxal 5'-phosphate binding site [chemical binding]; other site 991791004579 homodimer interface [polypeptide binding]; other site 991791004580 catalytic residue [active] 991791004581 cobalamin biosynthesis protein CbiG; Validated; Region: PRK05788 991791004582 Cobalamin synthesis G N-terminal; Region: CbiG_N; pfam11760 991791004583 Cobalamin biosynthesis central region; Region: CbiG_mid; pfam11761 991791004584 Cobalamin synthesis G C-terminus; Region: CbiG_C; pfam01890 991791004585 Protein involved in propanediol utilization, and related proteins (includes coumermycin biosynthetic protein), possible kinase [Secondary metabolites biosynthesis, transport, and catabolism]; Region: PduX; COG4542 991791004586 GHMP kinases N terminal domain; Region: GHMP_kinases_N; pfam00288 991791004587 GHMP kinases C terminal; Region: GHMP_kinases_C; pfam08544 991791004588 Phosphoribosyltransferase; Region: DBI_PRT; pfam02277 991791004589 Nicotinate-nucleotide-dimethylbenzimidazole phosphoribosyltransferase (DMB-PRT), also called CobT; Region: DMB-PRT_CobT; cd02439 991791004590 putative dimer interface [polypeptide binding]; other site 991791004591 active site pocket [active] 991791004592 putative cataytic base [active] 991791004593 Cobalamin biosynthesis protein CbiK, Co2+ chelatase [Coenzyme metabolism]; Region: CbiK; COG4822 991791004594 Anaerobic cobalamin biosynthetic cobalt chelatase (CbiK), N-terminal domain. CbiK is part of the cobalt-early path for cobalamin biosynthesis. It catalyzes the insertion of cobalt into the oxidized form of precorrin-2, factor II (sirohydrochlorin), the...; Region: CbiK_N; cd03412 991791004595 active site 991791004596 C-terminal domain interface [polypeptide binding]; other site 991791004597 Anaerobic cobalamin biosynthetic cobalt chelatase (CbiK), C-terminal domain. CbiK is part of the cobalt-early path for cobalamin biosynthesis. It catalyzes the insertion of cobalt into the oxidized form of precorrin-2, factor II (sirohydrochlorin), the...; Region: CbiK_C; cd03413 991791004598 active site 991791004599 N-terminal domain interface [polypeptide binding]; other site 991791004600 cobyric acid synthase; Provisional; Region: PRK00784 991791004601 The Fer4_NifH superfamily contains a variety of proteins which share a common ATP-binding domain. Functionally, proteins in this superfamily use the energy from hydrolysis of NTP to transfer electron or ion; Region: Fer4_NifH; cl17203 991791004602 The Fer4_NifH superfamily contains a variety of proteins which share a common ATP-binding domain. Functionally, proteins in this superfamily use the energy from hydrolysis of NTP to transfer electron or ion; Region: Fer4_NifH; cl17203 991791004603 Type 1 glutamine amidotransferase (GATase1) domain found in Cobyric Acid Synthase (CobQ); Region: GATase1_CobQ; cd01750 991791004604 catalytic triad [active] 991791004605 Cobyrinic acid a,c-diamide synthase [Coenzyme metabolism]; Region: CobB; COG1797 991791004606 Type 1 glutamine amidotransferase (GATase1) domain found in Cobyrinic Acid a,c-Diamide Synthase; Region: GATase1_CobB; cd03130 991791004607 catalytic triad [active] 991791004608 cobalt-precorrin-8X methylmutase; Validated; Region: cbiC; cl00913 991791004609 precorrin-8X methylmutase; Validated; Region: cbiC; PRK05575 991791004610 Cobalamin biosynthesis protein CbiD [Coenzyme metabolism]; Region: CbiD; COG1903 991791004611 Precorrin-6B methylase 2 [Coenzyme metabolism]; Region: CobL; COG2242 991791004612 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 991791004613 S-adenosylmethionine binding site [chemical binding]; other site 991791004614 Precorrin-2 C20-methyltransferase, also named CobI or CbiL; Region: Precorrin_2_C20_MT; cd11645 991791004615 active site 991791004616 SAM binding site [chemical binding]; other site 991791004617 homodimer interface [polypeptide binding]; other site 991791004618 Precorrin-4 C11-methyltransferase (CbiF/CobM); Region: Precorrin-4_C11-MT; cd11641 991791004619 active site 991791004620 SAM binding site [chemical binding]; other site 991791004621 homodimer interface [polypeptide binding]; other site 991791004622 Precorrin-6x reductase [Coenzyme metabolism]; Region: CobK; COG2099 991791004623 cobalt-precorrin-6x reductase; Reviewed; Region: PRK08057 991791004624 Precorrin-3B C(17)-methyltransferase (CobJ/CbiH); Region: Precorrin_3B_C17_MT; cd11646 991791004625 active site 991791004626 SAM binding site [chemical binding]; other site 991791004627 homodimer interface [polypeptide binding]; other site 991791004628 Adenosylcobinamide kinase / adenosylcobinamide phosphate guanyltransferase (CobU). CobU is bifunctional cobalbumin biosynthesis enzymes which display adenosylcobinamide kinase and adenosylcobinamide phosphate guanyltransferase activity. This enzyme is a...; Region: CobU; cd00544 991791004629 homotrimer interface [polypeptide binding]; other site 991791004630 Walker A motif; other site 991791004631 GTP binding site [chemical binding]; other site 991791004632 Walker B motif; other site 991791004633 cobalamin synthase; Reviewed; Region: cobS; PRK00235 991791004634 Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067 991791004635 catalytic core [active] 991791004636 Metallo-beta-lactamase superfamily; Region: Lactamase_B; smart00849 991791004637 Four helix bundle sensory module for signal transduction; Region: 4HB_MCP_1; pfam12729 991791004638 Methyl-accepting chemotaxis protein [Cell motility and secretion / Signal transduction mechanisms]; Region: Tar; COG0840 991791004639 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 991791004640 dimerization interface [polypeptide binding]; other site 991791004641 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 991791004642 dimer interface [polypeptide binding]; other site 991791004643 putative CheW interface [polypeptide binding]; other site 991791004644 Small, acid-soluble spore proteins, alpha/beta type; Region: SASP; pfam00269 991791004645 Uncharacterized conserved protein, contains double-stranded beta-helix domain [Function unknown]; Region: COG3837 991791004646 Bacterial surface proteins containing Ig-like domains [Cell motility and secretion]; Region: COG5492 991791004647 Clostridial hydrophobic, with a conserved W residue, domain; Region: ChW; smart00728 991791004648 Clostridial hydrophobic, with a conserved W residue, domain; Region: ChW; smart00728 991791004649 Clostridial hydrophobic, with a conserved W residue, domain; Region: ChW; smart00728 991791004650 Bacterial Ig-like domain (group 2); Region: Big_2; pfam02368 991791004651 Bacterial surface proteins containing Ig-like domains [Cell motility and secretion]; Region: COG5492 991791004652 Clostridial hydrophobic, with a conserved W residue, domain; Region: ChW; smart00728 991791004653 Clostridial hydrophobic, with a conserved W residue, domain; Region: ChW; smart00728 991791004654 Clostridial hydrophobic, with a conserved W residue, domain; Region: ChW; smart00728 991791004655 Clostridial hydrophobic, with a conserved W residue, domain; Region: ChW; smart00728 991791004656 Clostridial hydrophobic, with a conserved W residue, domain; Region: ChW; smart00728 991791004657 Phosphoribosylcarboxyaminoimidazole (NCAIR) mutase [Nucleotide transport and metabolism]; Region: PurE; COG0041 991791004658 phosphoribosylaminoimidazole-succinocarboxamide synthase; Reviewed; Region: PRK09362 991791004659 bacterial and archaeal 5-aminoimidazole-4-(N-succinylcarboxamide) ribonucleotide (SAICAR) synthase; Region: SAICAR_synt_PurC; cd01415 991791004660 ATP binding site [chemical binding]; other site 991791004661 active site 991791004662 substrate binding site [chemical binding]; other site 991791004663 amidophosphoribosyltransferase; Provisional; Region: PRK05793 991791004664 Glutamine amidotransferases class-II (GN-AT)_GPAT- type. This domain is found at the N-terminus of glutamine phosphoribosylpyrophosphate (Prpp) amidotransferase (GPATase) . The glutaminase domain catalyzes amide nitrogen transfer from glutamine to the...; Region: GPATase_N; cd00715 991791004665 active site 991791004666 tetramer interface [polypeptide binding]; other site 991791004667 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 991791004668 active site 991791004669 phosphoribosylaminoimidazole synthetase; Provisional; Region: PRK05385 991791004670 PurM (Aminoimidazole Ribonucleotide [AIR] synthetase), one of eleven enzymes required for purine biosynthesis, catalyzes the conversion of formylglycinamide ribonucleotide (FGAM) and ATP to AIR, ADP, and Pi, the fifth step in de novo purine biosynthesis; Region: PurM; cd02196 991791004671 dimerization interface [polypeptide binding]; other site 991791004672 putative ATP binding site [chemical binding]; other site 991791004673 phosphoribosylglycinamide formyltransferase; Reviewed; Region: purN; PRK05647 991791004674 Phosphoribosylglycinamide formyltransferase (GAR transformylase, GART); Region: FMT_core_GART; cd08645 991791004675 active site 991791004676 substrate binding site [chemical binding]; other site 991791004677 cosubstrate binding site; other site 991791004678 catalytic site [active] 991791004679 bifunctional phosphoribosylaminoimidazolecarboxamide formyltransferase/IMP cyclohydrolase; Provisional; Region: purH; PRK00881 991791004680 Inosine monophosphate cyclohydrolase domain. This is the N-terminal domain in the purine biosynthesis pathway protein ATIC (purH). The bifunctional ATIC protein contains a C-terminal ATIC formylase domain that formylates...; Region: IMPCH; cd01421 991791004681 purine monophosphate binding site [chemical binding]; other site 991791004682 dimer interface [polypeptide binding]; other site 991791004683 putative catalytic residues [active] 991791004684 AICARFT/IMPCHase bienzyme; Region: AICARFT_IMPCHas; smart00798 991791004685 AICARFT/IMPCHase bienzyme; Region: AICARFT_IMPCHas; cl03362 991791004686 phosphoribosylamine--glycine ligase; Provisional; Region: PRK00885 991791004687 Phosphoribosylglycinamide synthetase, N domain; Region: GARS_N; pfam02844 991791004688 Phosphoribosylglycinamide synthetase, ATP-grasp (A) domain; Region: GARS_A; pfam01071 991791004689 Phosphoribosylglycinamide synthetase, C domain; Region: GARS_C; pfam02843 991791004690 Predicted metal-dependent hydrolases with the TIM-barrel fold [General function prediction only]; Region: COG1099 991791004691 TatD like proteins; E.coli TatD is a cytoplasmic protein, shown to have magnesium dependent DNase activity; Region: TatD_DNAse; cd01310 991791004692 active site 991791004693 Domain of unknown function DUF77; Region: DUF77; pfam01910 991791004694 ABC-type nitrate/sulfonate/bicarbonate transport system, permease component [Inorganic ion transport and metabolism]; Region: TauC; COG0600 991791004695 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 991791004696 dimer interface [polypeptide binding]; other site 991791004697 conserved gate region; other site 991791004698 ABC-ATPase subunit interface; other site 991791004699 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cl17432 991791004700 NMT1/THI5 like; Region: NMT1; pfam09084 991791004701 ABC-type nitrate/sulfonate/bicarbonate transport system, ATPase component [Inorganic ion transport and metabolism]; Region: TauB; COG1116 991791004702 ATP-binding cassette domain of the nitrate and sulfonate transporters; Region: ABC_NrtD_SsuB_transporters; cd03293 991791004703 Walker A/P-loop; other site 991791004704 ATP binding site [chemical binding]; other site 991791004705 Q-loop/lid; other site 991791004706 ABC transporter signature motif; other site 991791004707 Walker B; other site 991791004708 D-loop; other site 991791004709 H-loop/switch region; other site 991791004710 Protein involved in polysaccharide intercellular adhesin (PIA) synthesis/biofilm formation [Carbohydrate transport and metabolism]; Region: COG3936 991791004711 Metallo-beta-lactamase superfamily; Region: Lactamase_B; smart00849 991791004712 Transcriptional regulators of sugar metabolism [Transcription / Carbohydrate transport and metabolism]; Region: GlpR; COG1349 991791004713 helix_turn_helix, Deoxyribose operon repressor; Region: HTH_DEOR; smart00420 991791004714 DeoR C terminal sensor domain; Region: DeoRC; pfam00455 991791004715 Glycosyl hydrolase family 1; Region: Glyco_hydro_1; cl01046 991791004716 beta-galactosidase; Region: BGL; TIGR03356 991791004717 CAT RNA binding domain; Region: CAT_RBD; pfam03123 991791004718 transcriptional antiterminator BglG; Provisional; Region: PRK09772 991791004719 PRD domain; Region: PRD; pfam00874 991791004720 PRD domain; Region: PRD; pfam00874 991791004721 PTS system, beta-glucoside-specific IIABC component; Region: PTS-II-ABC-beta; TIGR01995 991791004722 PTS_IIB, PTS system, glucose/sucrose specific IIB subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIB_glc; cd00212 991791004723 active site turn [active] 991791004724 phosphorylation site [posttranslational modification] 991791004725 Phosphotransferase system IIC components, glucose/maltose/N-acetylglucosamine-specific [Carbohydrate transport and metabolism]; Region: PtsG; COG1263 991791004726 PTS_IIA, PTS system, glucose/sucrose specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIA_glc; cd00210 991791004727 HPr interaction site; other site 991791004728 glycerol kinase (GK) interaction site [polypeptide binding]; other site 991791004729 active site 991791004730 phosphorylation site [posttranslational modification] 991791004731 Glycosyl hydrolase family 1; Region: Glyco_hydro_1; cl01046 991791004732 beta-galactosidase; Region: BGL; TIGR03356 991791004733 Domain of unknown function (DUF4356); Region: DUF4356; pfam14266 991791004734 Domain of unknown function (DUF4356); Region: DUF4356; pfam14266 991791004735 Uncharacterized protein involved in tellurite resistance [Inorganic ion transport and metabolism]; Region: TelA; COG3853 991791004736 Uncharacterized proteins involved in stress response, homologs of TerZ and putative cAMP-binding protein CABP1 [Signal transduction mechanisms]; Region: TerZ; COG2310 991791004737 Uncharacterized proteins involved in stress response, similar to tellurium resistance terD; Region: TerD_like; cd06974 991791004738 putative metal binding site [ion binding]; other site 991791004739 Uncharacterized protein involved in stress response [General function prediction only]; Region: COG4110 991791004740 Uncharacterized proteins involved in stress response, similar to tellurium resistance terD; Region: TerD_like; cd06974 991791004741 putative metal binding site [ion binding]; other site 991791004742 Uncharacterized proteins involved in stress response, homologs of TerZ and putative cAMP-binding protein CABP1 [Signal transduction mechanisms]; Region: TerZ; COG2310 991791004743 Uncharacterized proteins involved in stress response, similar to tellurium resistance terD; Region: TerD_like; cd06974 991791004744 putative metal binding site [ion binding]; other site 991791004745 integral membrane protein, YkoY family; Region: R_switched_YkoY; TIGR03716 991791004746 Acetyltransferases, including N-acetylases of ribosomal proteins [Translation, ribosomal structure and biogenesis]; Region: RimL; COG1670 991791004747 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 991791004748 Coenzyme A binding pocket [chemical binding]; other site 991791004749 Nitroreductase-like family 3. A subfamily of the nitroreductase family containing uncharacterized proteins that are similar to nitroreductase. Nitroreductase catalyzes the reduction of nitroaromatic compounds such as nitrotoluenes, nitrofurans and...; Region: Nitroreductase_3; cd02139 991791004750 putative FMN binding site [chemical binding]; other site 991791004751 Microcin C7 self-immunity protein determines resistance to exogenous microcin C7; Region: Peptidase_S66_mccF_like; cd07062 991791004752 putative dimer interface [polypeptide binding]; other site 991791004753 catalytic triad [active] 991791004754 hypothetical protein; Provisional; Region: PRK03881 991791004755 The N-terminal domain, an extradiol dioxygenase class III subunit B-like domain, of unknown proteins containing a C-terminal AMMECR1 domain; Region: ED_3B_N_AMMECR1; cd07951 991791004756 Uncharacterized conserved protein [Function unknown]; Region: AMMECR1; COG2078 991791004757 Pyruvate-formate lyase-activating enzyme [Posttranslational modification, protein turnover, chaperones]; Region: PflA; COG1180 991791004758 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 991791004759 FeS/SAM binding site; other site 991791004760 Hemolysins and related proteins containing CBS domains [General function prediction only]; Region: TlyC; COG1253 991791004761 Domain of unknown function DUF21; Region: DUF21; pfam01595 991791004762 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains associated with the CorC_HlyC domain. CorC_HlyC is a transporter associated domain. This small domain is found in Na+/H+ antiporters, in proteins involved in...; Region: CBS_pair_CorC_HlyC_assoc; cd04590 991791004763 Transporter associated domain; Region: CorC_HlyC; smart01091 991791004764 short chain dehydrogenase; Provisional; Region: PRK06701 991791004765 classical (c) SDR, subgroup 1; Region: SDR_c1; cd05355 991791004766 NAD binding site [chemical binding]; other site 991791004767 metal binding site [ion binding]; metal-binding site 991791004768 active site 991791004769 Metallo-beta-lactamase superfamily; Region: Lactamase_B; smart00849 991791004770 Trimeric dUTP diphosphatases; Region: trimeric_dUTPase; cd07557 991791004771 trimer interface [polypeptide binding]; other site 991791004772 active site 991791004773 Regulator of polyketide synthase expression [Signal transduction mechanisms / Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG2508 991791004774 PucR C-terminal helix-turn-helix domain; Region: HTH_30; pfam13556 991791004775 4-aminobutyrate aminotransferase and related aminotransferases [Amino acid transport and metabolism]; Region: GabT; COG0160 991791004776 Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610 991791004777 inhibitor-cofactor binding pocket; inhibition site 991791004778 pyridoxal 5'-phosphate binding site [chemical binding]; other site 991791004779 catalytic residue [active] 991791004780 UDP-glucose 4-epimerase [Cell envelope biogenesis, outer membrane]; Region: GalE; COG1087 991791004781 UDP-glucose 4 epimerase, subgroup 1, extended (e) SDRs; Region: UDP_G4E_1_SDR_e; cd05247 991791004782 NAD binding site [chemical binding]; other site 991791004783 homodimer interface [polypeptide binding]; other site 991791004784 active site 991791004785 substrate binding site [chemical binding]; other site 991791004786 Transcriptional regulators of sugar metabolism [Transcription / Carbohydrate transport and metabolism]; Region: GlpR; COG1349 991791004787 helix_turn_helix, Deoxyribose operon repressor; Region: HTH_DEOR; smart00420 991791004788 DeoR C terminal sensor domain; Region: DeoRC; pfam00455 991791004789 RPI_A: Ribose 5-phosphate isomerase type A (RPI_A) subfamily; RPI catalyzes the reversible conversion of ribose-5-phosphate to ribulose 5-phosphate, the first step of the non-oxidative branch of the pentose phosphate pathway. This reaction leads to the...; Region: RPI_A; cd01398 991791004790 tetramer (dimer of dimers) interface [polypeptide binding]; other site 991791004791 active site 991791004792 dimer interface [polypeptide binding]; other site 991791004793 Undecaprenyl pyrophosphate synthase [Lipid metabolism]; Region: UppS; COG0020 991791004794 Cis (Z)-Isoprenyl Diphosphate Synthases (cis-IPPS); homodimers which catalyze the successive 1'-4 condensation of the isopentenyl diphosphate (IPP) molecule to trans,trans-farnesyl diphosphate (FPP) or to cis,trans-FPP to form long-chain polyprenyl...; Region: CIS_IPPS; cl00230 991791004795 catalytic residue [active] 991791004796 putative FPP diphosphate binding site; other site 991791004797 putative FPP binding hydrophobic cleft; other site 991791004798 dimer interface [polypeptide binding]; other site 991791004799 putative IPP diphosphate binding site; other site 991791004800 Predicted hydrolases of the HAD superfamily [General function prediction only]; Region: Cof; COG0561 991791004801 Phosphoglycerol transferase and related proteins, alkaline phosphatase superfamily [Cell envelope biogenesis, outer membrane]; Region: MdoB; COG1368 991791004802 Sulfatase; Region: Sulfatase; cl17466 991791004803 SAM-dependent methyltransferases related to tRNA (uracil-5-)-methyltransferase [Translation, ribosomal structure and biogenesis]; Region: TrmA; COG2265 991791004804 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 991791004805 S-adenosylmethionine binding site [chemical binding]; other site 991791004806 AAA ATPase domain; Region: AAA_16; pfam13191 991791004807 Bacterial protein of unknown function (DUF961); Region: DUF961; pfam06125 991791004808 Glycopeptide antibiotics resistance protein [Defense mechanisms]; Region: VanZ; COG4767 991791004809 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 991791004810 Major Facilitator Superfamily; Region: MFS_1; pfam07690 991791004811 putative substrate translocation pore; other site 991791004812 Translation elongation factors (GTPases) [Translation, ribosomal structure and biogenesis]; Region: FusA; COG0480 991791004813 Tet(M)-like family includes Tet(M), Tet(O), Tet(W), and OtrA, containing tetracycline resistant proteins; Region: TetM_like; cd04168 991791004814 G1 box; other site 991791004815 putative GEF interaction site [polypeptide binding]; other site 991791004816 GTP/Mg2+ binding site [chemical binding]; other site 991791004817 Switch I region; other site 991791004818 G2 box; other site 991791004819 G3 box; other site 991791004820 Switch II region; other site 991791004821 G4 box; other site 991791004822 Tet_II: This subfamily represents domain II of ribosomal protection proteins Tet(M) and Tet(O). This domain has homology to domain II of the elongation factors EF-G and EF-2. Tet(M) and Tet(O) catalyze the release of tetracycline (Tc) from the ribosome...; Region: Tet_II; cd03690 991791004823 EF-G_domain IV_RPP domain is a part of bacterial ribosomal protected proteins (RPP) family. RPPs such as tetracycline resistance proteins Tet(M) and Tet(O) mediate tetracycline resistance in both gram-positive and -negative species. Tetracyclines inhibit...; Region: Tet_like_IV; cd01684 991791004824 Tet_C: C-terminus of ribosomal protection proteins Tet(M) and Tet(O). This domain has homology to the C terminal domains of the elongation factors EF-G and EF-2. Tet(M) and Tet(O) catalyze the release of tetracycline (Tc) from the ribosome in a...; Region: Tet_C; cd03711 991791004825 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 991791004826 AraC-like ligand binding domain; Region: AraC_binding; pfam02311 991791004827 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 991791004828 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 991791004829 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 991791004830 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 991791004831 Major Facilitator Superfamily; Region: MFS_1; pfam07690 991791004832 putative substrate translocation pore; other site 991791004833 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 991791004834 ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: RbsB; COG1879 991791004835 Periplasmic sugar-binding domain of active transport systems that are members of the type I periplasmic binding protein (PBP1) superfamily; Region: PBP1_ABC_sugar_binding_like; cd01536 991791004836 ligand binding site [chemical binding]; other site 991791004837 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: COG4585 991791004838 Histidine kinase; Region: HisKA_3; pfam07730 991791004839 Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase; Region: HATPase_c; pfam02518 991791004840 Mg2+ binding site [ion binding]; other site 991791004841 G-X-G motif; other site 991791004842 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 991791004843 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 991791004844 active site 991791004845 phosphorylation site [posttranslational modification] 991791004846 intermolecular recognition site; other site 991791004847 dimerization interface [polypeptide binding]; other site 991791004848 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 991791004849 dimerization interface [polypeptide binding]; other site 991791004850 DNA binding residues [nucleotide binding] 991791004851 ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653 991791004852 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; pfam01547 991791004853 PTS_IIA, PTS system, mannose/sorbose specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIA_man; cd00006 991791004854 active pocket/dimerization site; other site 991791004855 active site 991791004856 phosphorylation site [posttranslational modification] 991791004857 PTS_IIB, PTS system, Mannose/sorbose specific IIB subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIB_man; cd00001 991791004858 active site 991791004859 phosphorylation site [posttranslational modification] 991791004860 Phosphotransferase system, mannose/fructose/N-acetylgalactosamine-specific component IIC [Carbohydrate transport and metabolism]; Region: ManY; COG3715 991791004861 Phosphotransferase system, mannose/fructose/N-acetylgalactosamine-specific component IID [Carbohydrate transport and metabolism]; Region: ManZ; COG3716 991791004862 Beta-fructosidases (levanase/invertase) [Carbohydrate transport and metabolism]; Region: SacC; COG1621 991791004863 Glycosyl hydrolase family 32, beta-fructosidases; Region: GH32_B_Fructosidase; cd08996 991791004864 substrate binding [chemical binding]; other site 991791004865 active site 991791004866 Glycosyl hydrolase families: GH43, GH62, GH32, GH68; Region: GH43_62_32_68; cl14647 991791004867 Glycosyl hydrolases family 32 C terminal; Region: Glyco_hydro_32C; pfam08244 991791004868 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 991791004869 sequence-specific DNA binding site [nucleotide binding]; other site 991791004870 salt bridge; other site 991791004871 ATP-binding cassette domain I of the excision repair protein UvrA; Region: ABC_UvrA_I; cd03270 991791004872 ATP-binding cassette domain I of the excision repair protein UvrA; Region: ABC_UvrA_I; cd03270 991791004873 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 991791004874 ABC-type cobalt transport system, ATPase component [Inorganic ion transport and metabolism]; Region: CbiO; COG1122 991791004875 Walker A/P-loop; other site 991791004876 ATP binding site [chemical binding]; other site 991791004877 Q-loop/lid; other site 991791004878 ABC transporter signature motif; other site 991791004879 Walker B; other site 991791004880 D-loop; other site 991791004881 H-loop/switch region; other site 991791004882 helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347 991791004883 MarR family; Region: MarR_2; pfam12802 991791004884 Uncharacterized conserved protein [Function unknown]; Region: COG2128 991791004885 Transcriptional regulators [Transcription]; Region: Lrp; COG1522 991791004886 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 991791004887 putative DNA binding site [nucleotide binding]; other site 991791004888 putative Zn2+ binding site [ion binding]; other site 991791004889 AsnC family; Region: AsnC_trans_reg; pfam01037 991791004890 Acetyltransferase (GNAT) domain; Region: Acetyltransf_10; pfam13673 991791004891 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 991791004892 Coenzyme A binding pocket [chemical binding]; other site 991791004893 Iron dependent repressor, N-terminal DNA binding domain; Region: Fe_dep_repress; pfam01325 991791004894 Helix-turn-helix diphteria tox regulatory element; Region: HTH_DTXR; smart00529 991791004895 Iron dependent repressor, metal binding and dimerisation domain; Region: Fe_dep_repr_C; pfam02742 991791004896 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 991791004897 Ketopantoate reductase [Coenzyme metabolism]; Region: ApbA; COG1893 991791004898 Ketopantoate reductase PanE/ApbA; Region: ApbA; pfam02558 991791004899 Gamma-aminobutyrate permease and related permeases [Amino acid transport and metabolism]; Region: AnsP; COG1113 991791004900 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 991791004901 dimer interface [polypeptide binding]; other site 991791004902 conserved gate region; other site 991791004903 putative PBP binding loops; other site 991791004904 ABC-ATPase subunit interface; other site 991791004905 ABC-type proline/glycine betaine transport systems, periplasmic components [Amino acid transport and metabolism]; Region: ProX; cl17891 991791004906 Periplasmic glycine betaine/choline-binding (lipo)protein of an ABC-type transport system (osmoprotectant binding protein) [Cell envelope biogenesis, outer membrane]; Region: OpuBC; COG1732 991791004907 ATP-binding cassette domain of the osmoprotectant transporter; Region: ABC_OpuCA_Osmoprotection; cd03295 991791004908 sulfate ABC transporter, ATP-binding protein; Region: 3a0106s01; TIGR00968 991791004909 Walker A/P-loop; other site 991791004910 ATP binding site [chemical binding]; other site 991791004911 Q-loop/lid; other site 991791004912 ABC transporter signature motif; other site 991791004913 Walker B; other site 991791004914 D-loop; other site 991791004915 H-loop/switch region; other site 991791004916 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 991791004917 dimer interface [polypeptide binding]; other site 991791004918 conserved gate region; other site 991791004919 putative PBP binding loops; other site 991791004920 ABC-ATPase subunit interface; other site 991791004921 30S ribosomal protein S4; Validated; Region: rpsD; PRK05327 991791004922 Ribosomal protein S4/S9 N-terminal domain; Region: Ribosomal_S4; pfam00163 991791004923 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 991791004924 RNA binding surface [nucleotide binding]; other site 991791004925 branched-chain amino acid aminotransferase; Provisional; Region: PRK13357 991791004926 BCAT_beta_family: Branched-chain aminotransferase catalyses the transamination of the branched-chain amino acids leusine, isoleucine and valine to their respective alpha-keto acids, alpha-ketoisocaproate, alpha-keto-beta-methylvalerate and...; Region: BCAT_beta_family; cd01557 991791004927 homodimer interface [polypeptide binding]; other site 991791004928 substrate-cofactor binding pocket; other site 991791004929 catalytic residue [active] 991791004930 Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673 991791004931 Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408 991791004932 Oxidoreductase family, C-terminal alpha/beta domain; Region: GFO_IDH_MocA_C; pfam02894 991791004933 Transcriptional regulator [Transcription]; Region: LysR; COG0583 991791004934 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 991791004935 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cd05466 991791004936 dimerization interface [polypeptide binding]; other site 991791004937 Uncharacterized membrane protein, possible Na+ channel or pump [General function prediction only]; Region: COG1811 991791004938 Predicted transcriptional regulators [Transcription]; Region: COG1733 991791004939 HxlR-like helix-turn-helix; Region: HxlR; pfam01638 991791004940 Nitroreductase-like family 3. A subfamily of the nitroreductase family containing uncharacterized proteins that are similar to nitroreductase. Nitroreductase catalyzes the reduction of nitroaromatic compounds such as nitrotoluenes, nitrofurans and...; Region: Nitroreductase_3; cd02139 991791004941 putative FMN binding site [chemical binding]; other site 991791004942 Glycosyltransferases, probably involved in cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: COG1215 991791004943 CESA_CelA_like are involved in the elongation of the glucan chain of cellulose; Region: CESA_CelA_like; cd06421 991791004944 DXD motif; other site 991791004945 PilZ domain; Region: PilZ; pfam07238 991791004946 Uncharacterized protein family (UPF0180); Region: UPF0180; pfam03698 991791004947 small acid-soluble spore protein Tlp; Provisional; Region: PRK03830 991791004948 putative glycosyl transferase; Provisional; Region: PRK10073 991791004949 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cd00761 991791004950 active site 991791004951 Membrane-associated phospholipid phosphatase [Lipid metabolism]; Region: PgpB; COG0671 991791004952 PAP2_like proteins, Aur1_like subfamily. Yeast Aur1p or Ipc1p is necessary for the addition of inositol phosphate to ceramide, an essential step in yeast sphingolipid synthesis, and is the target of several antifungal compounds such as aureobasidin; Region: PAP2_Aur1_like; cd03386 991791004953 active site 991791004954 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4185 991791004955 Pirin-related protein [General function prediction only]; Region: COG1741 991791004956 Pirin; Region: Pirin; pfam02678 991791004957 Pirin C-terminal cupin domain; Region: Pirin_C; pfam05726 991791004958 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3677 991791004959 ISXO2-like transposase domain; Region: DDE_Tnp_IS1595; cl01481 991791004960 RibD C-terminal domain; Region: RibD_C; cl17279 991791004961 Dihydrofolate reductase [Coenzyme metabolism]; Region: FolA; COG0262 991791004962 Predicted nucleotidyltransferase [General function prediction only]; Region: COG3541 991791004963 Predicted nucleotidyltransferase; Region: Nuc-transf; pfam10127 991791004964 Flavodoxin-like fold; Region: Flavodoxin_2; cl00438 991791004965 endonuclease III; includes endonuclease III (DNA-(apurinic or apyrimidinic site) lyase), alkylbase DNA glycosidases (Alka-family) and other DNA glycosidases; Region: ENDO3c; cd00056 991791004966 endonuclease III; Region: ENDO3c; smart00478 991791004967 minor groove reading motif; other site 991791004968 helix-hairpin-helix signature motif; other site 991791004969 substrate binding pocket [chemical binding]; other site 991791004970 active site 991791004971 Cytosine-C5 specific DNA methylases; Methyl transfer reactions play an important role in many aspects of biology. Cytosine-specific DNA methylases are found both in prokaryotes and eukaryotes. DNA methylation, or the covalent addition of a methyl group...; Region: Cyt_C5_DNA_methylase; cd00315 991791004972 DNA-methyltransferase (dcm); Region: dcm; TIGR00675 991791004973 cofactor binding site; other site 991791004974 DNA binding site [nucleotide binding] 991791004975 substrate interaction site [chemical binding]; other site 991791004976 Cytosine-C5 specific DNA methylases; Methyl transfer reactions play an important role in many aspects of biology. Cytosine-specific DNA methylases are found both in prokaryotes and eukaryotes. DNA methylation, or the covalent addition of a methyl group...; Region: Cyt_C5_DNA_methylase; cd00315 991791004977 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 991791004978 putative substrate translocation pore; other site 991791004979 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 991791004980 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 991791004981 active site 991791004982 phosphorylation site [posttranslational modification] 991791004983 intermolecular recognition site; other site 991791004984 dimerization interface [polypeptide binding]; other site 991791004985 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 991791004986 DNA binding site [nucleotide binding] 991791004987 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 991791004988 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 991791004989 dimerization interface [polypeptide binding]; other site 991791004990 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 991791004991 dimer interface [polypeptide binding]; other site 991791004992 phosphorylation site [posttranslational modification] 991791004993 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 991791004994 ATP binding site [chemical binding]; other site 991791004995 Mg2+ binding site [ion binding]; other site 991791004996 G-X-G motif; other site 991791004997 RNA polymerase sigma-70 factor, TIGR02952 family; Region: Sig70_famx2 991791004998 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 991791004999 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cl17257 991791005000 DNA binding residues [nucleotide binding] 991791005001 Domain of unknown function (DUF4367); Region: DUF4367; pfam14285 991791005002 cAMP-binding proteins - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases [Signal transduction mechanisms]; Region: Crp; COG0664 991791005003 effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038 991791005004 ligand binding site [chemical binding]; other site 991791005005 flexible hinge region; other site 991791005006 Crp-like helix-turn-helix domain; Region: HTH_Crp_2; pfam13545 991791005007 putative switch regulator; other site 991791005008 non-specific DNA interactions [nucleotide binding]; other site 991791005009 DNA binding site [nucleotide binding] 991791005010 sequence specific DNA binding site [nucleotide binding]; other site 991791005011 putative cAMP binding site [chemical binding]; other site 991791005012 Formate/nitrite family of transporters [Inorganic ion transport and metabolism]; Region: FocA; COG2116 991791005013 sulfite reductase, subunit A; Region: sulfite_red_A; TIGR02910 991791005014 sulfite reductase, subunit B; Region: sulfite_red_B; TIGR02911 991791005015 Anaerobic sulfite reductase contains an FAD and NADPH binding module with structural similarity to ferredoxin reductase and sequence similarity to dihydroorotate dehydrogenases. Clostridium pasteurianum inducible dissimilatory type sulfite reductase is...; Region: sulfite_reductase_like; cd06221 991791005016 FAD binding pocket [chemical binding]; other site 991791005017 FAD binding motif [chemical binding]; other site 991791005018 phosphate binding motif [ion binding]; other site 991791005019 beta-alpha-beta structure motif; other site 991791005020 NAD binding pocket [chemical binding]; other site 991791005021 Iron coordination center [ion binding]; other site 991791005022 sulfite reductase, subunit C; Region: sulfite_red_C; TIGR02912 991791005023 Nitrite/Sulfite reductase ferredoxin-like half domain; Region: NIR_SIR_ferr; pfam03460 991791005024 4Fe-4S binding domain; Region: Fer4; pfam00037 991791005025 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 991791005026 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 991791005027 active site 991791005028 phosphorylation site [posttranslational modification] 991791005029 intermolecular recognition site; other site 991791005030 dimerization interface [polypeptide binding]; other site 991791005031 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 991791005032 DNA binding site [nucleotide binding] 991791005033 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 991791005034 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 991791005035 dimer interface [polypeptide binding]; other site 991791005036 phosphorylation site [posttranslational modification] 991791005037 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 991791005038 ATP binding site [chemical binding]; other site 991791005039 Mg2+ binding site [ion binding]; other site 991791005040 G-X-G motif; other site 991791005041 ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136 991791005042 ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255 991791005043 Walker A/P-loop; other site 991791005044 ATP binding site [chemical binding]; other site 991791005045 Q-loop/lid; other site 991791005046 ABC transporter signature motif; other site 991791005047 Walker B; other site 991791005048 D-loop; other site 991791005049 H-loop/switch region; other site 991791005050 ABC-type antimicrobial peptide transport system, permease component [Defense mechanisms]; Region: SalY; COG0577 991791005051 FtsX-like permease family; Region: FtsX; pfam02687 991791005052 ABC-type antimicrobial peptide transport system, permease component [Defense mechanisms]; Region: SalY; COG0577 991791005053 FtsX-like permease family; Region: FtsX; pfam02687 991791005054 Domain of unknown function (DUF4363); Region: DUF4363; pfam14276 991791005055 Predicted membrane protein [Function unknown]; Region: COG2323 991791005056 Small, acid-soluble spore proteins, alpha/beta type; Region: SASP; pfam00269 991791005057 Transcriptional regulator/sugar kinase [Transcription / Carbohydrate transport and metabolism]; Region: NagC; COG1940 991791005058 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cl17037 991791005059 nucleotide binding site [chemical binding]; other site 991791005060 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 991791005061 dimer interface [polypeptide binding]; other site 991791005062 putative CheW interface [polypeptide binding]; other site 991791005063 Escherichia coli PhnB and similar proteins; the E. coli phnB gene is found next to an operon involved in the cleavage of carbon-phosphorus bonds in unactivated alkylphosphonates; Region: PhnB_like; cd06588 991791005064 dimer interface [polypeptide binding]; other site 991791005065 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 991791005066 CHAP domain; Region: CHAP; pfam05257 991791005067 Spore germination protein; Region: Spore_permease; pfam03845 991791005068 Glycosyl hydrolase family 43; Region: GH43_1; cd08980 991791005069 active site 991791005070 galactoside permease; Reviewed; Region: lacY; PRK09528 991791005071 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 991791005072 putative substrate translocation pore; other site 991791005073 Uncharacterized conserved protein [Function unknown]; Region: COG2461 991791005074 Family of unknown function (DUF438); Region: DUF438; pfam04282 991791005075 Hemerythrin HHE cation binding domain; Region: Hemerythrin; pfam01814 991791005076 Bacterial surface proteins containing Ig-like domains [Cell motility and secretion]; Region: COG5492 991791005077 Clostridial hydrophobic, with a conserved W residue, domain; Region: ChW; smart00728 991791005078 Clostridial hydrophobic, with a conserved W residue, domain; Region: ChW; smart00728 991791005079 Clostridial hydrophobic, with a conserved W residue, domain; Region: ChW; smart00728 991791005080 Clostridial hydrophobic, with a conserved W residue, domain; Region: ChW; smart00728 991791005081 Clostridial hydrophobic, with a conserved W residue, domain; Region: ChW; smart00728 991791005082 Clostridial hydrophobic, with a conserved W residue, domain; Region: ChW; smart00728 991791005083 MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704 991791005084 ABC-type transport system, involved in lipoprotein release, permease component [Cell envelope biogenesis, outer membrane]; Region: LolE; COG4591 991791005085 MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704 991791005086 FtsX-like permease family; Region: FtsX; pfam02687 991791005087 ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136 991791005088 ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255 991791005089 Walker A/P-loop; other site 991791005090 ATP binding site [chemical binding]; other site 991791005091 Q-loop/lid; other site 991791005092 ABC transporter signature motif; other site 991791005093 Walker B; other site 991791005094 D-loop; other site 991791005095 H-loop/switch region; other site 991791005096 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 991791005097 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 991791005098 Uncharacterized conserved protein [Function unknown]; Region: COG2013 991791005099 EamA-like transporter family; Region: EamA; pfam00892 991791005100 Carboxylate/Amino Acid/Amine Transporter; Region: 2A78; TIGR00950 991791005101 EamA-like transporter family; Region: EamA; pfam00892 991791005102 Gamma-glutamylcysteine synthetase [Coenzyme metabolism]; Region: GshA; COG2918 991791005103 D-alanine-D-alanine ligase and related ATP-grasp enzymes [Cell envelope biogenesis, outer membrane]; Region: DdlA; COG1181 991791005104 ATP-grasp domain; Region: ATP-grasp_4; cl17255 991791005105 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cl17037 991791005106 Lactate dehydrogenase and related dehydrogenases [Energy production and conversion / Coenzyme metabolism / General function prediction only]; Region: LdhA; COG1052 991791005107 Putative Lactate dehydrogenase and (R)-2-Hydroxyglutarate Dehydrogenase-like proteins, NAD-binding and catalytic domains; Region: HGDH_LDH_like; cd12185 991791005108 putative ligand binding site [chemical binding]; other site 991791005109 putative NAD binding site [chemical binding]; other site 991791005110 catalytic site [active] 991791005111 Cytidine deaminase zinc-binding domain. These enzymes are Zn dependent. The zinc ion in the active site plays a central role in the proposed catalytic mechanism, activating a water molecule to form a hydroxide ion that performs a nucleophilic attack on...; Region: cytidine_deaminase; cd01283 991791005112 active site 991791005113 catalytic motif [active] 991791005114 Zn binding site [ion binding]; other site 991791005115 2-deoxyribose-5-phosphate aldolase (DERA) of the DeoC family; Region: DeoC; cd00959 991791005116 intersubunit interface [polypeptide binding]; other site 991791005117 active site 991791005118 catalytic residue [active] 991791005119 pyrimidine-nucleoside phosphorylase; Reviewed; Region: PRK06078 991791005120 Glycosyl transferase family, helical bundle domain; Region: Glycos_trans_3N; pfam02885 991791005121 Glycosyl transferase family, a/b domain; Region: Glycos_transf_3; pfam00591 991791005122 Pyrimidine nucleoside phosphorylase C-terminal domain; Region: PYNP_C; pfam07831 991791005123 TRX family; composed of two groups: Group I, which includes proteins that exclusively encode a TRX domain; and Group II, which are composed of fusion proteins of TRX and additional domains. Group I TRX is a small ancient protein that alter the redox...; Region: TRX_family; cd02947 991791005124 Thioredoxin-like; Region: Thioredoxin_8; pfam13905 991791005125 catalytic residues [active] 991791005126 Thioredoxin reductase [Posttranslational modification, protein turnover, chaperones]; Region: TrxB; COG0492 991791005127 Anaerobic glycerol-3-phosphate dehydrogenase [Amino acid transport and metabolism]; Region: GlpB; cl17730 991791005128 Glutathione (GSH) peroxidase family; tetrameric selenoenzymes that catalyze the reduction of a variety of hydroperoxides including lipid peroxidases, using GSH as a specific electron donor substrate. GSH peroxidase contains one selenocysteine residue per...; Region: GSH_Peroxidase; cd00340 991791005129 catalytic residues [active] 991791005130 dimer interface [polypeptide binding]; other site 991791005131 methionine sulfoxide reductase B; Provisional; Region: PRK00222 991791005132 SelR domain; Region: SelR; pfam01641 991791005133 NAD(P)H:flavin oxidoreductase-like family 1. A subfamily of the nitroreductase family containing uncharacterized proteins that are similar to nitroreductase. Nitroreductase catalyzes the reduction of nitroaromatic compounds such as nitrotoluenes; Region: NADPH_oxidoreductase_1; cd02150 991791005134 putative FMN binding site [chemical binding]; other site 991791005135 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 991791005136 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 991791005137 active site 991791005138 phosphorylation site [posttranslational modification] 991791005139 intermolecular recognition site; other site 991791005140 dimerization interface [polypeptide binding]; other site 991791005141 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 991791005142 DNA binding site [nucleotide binding] 991791005143 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 991791005144 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 991791005145 dimer interface [polypeptide binding]; other site 991791005146 phosphorylation site [posttranslational modification] 991791005147 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 991791005148 ATP binding site [chemical binding]; other site 991791005149 Mg2+ binding site [ion binding]; other site 991791005150 G-X-G motif; other site 991791005151 Heavy-metal-associated domain (HMA) is a conserved domain of approximately 30 amino acid residues found in a number of proteins that transport or detoxify heavy metals, for example, the CPx-type heavy metal ATPases and copper chaperones. HMA domain...; Region: HMA; cd00371 991791005152 metal-binding site [ion binding] 991791005153 Uncharacterized conserved protein [Function unknown]; Region: COG2836 991791005154 Cytochrome c biogenesis protein [Posttranslational modification, protein turnover, chaperones]; Region: CcdA; COG0785 991791005155 Plastocyanin domain containing protein [General function prediction only]; Region: COG4633 991791005156 Cupredoxin-like domain; Region: Cupredoxin_1; cl17234 991791005157 flagellin; Provisional; Region: PRK12804 991791005158 Bacterial flagellin N-terminal helical region; Region: Flagellin_N; pfam00669 991791005159 Bacterial flagellin C-terminal helical region; Region: Flagellin_C; pfam00700 991791005160 Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all...; Region: FN3; cd00063 991791005161 Predicted glycosyl hydrolase [General function prediction only]; Region: COG3858 991791005162 Interdomain contacts; other site 991791005163 Cytokine receptor motif; other site 991791005164 Cortical fragment-lytic enzyme (CFLE) is a peptidoglycan hydrolase involved in bacterial endospore germination. CFLE is expressed as an inactive preprotein (called SleB) in the forespore compartment of sporulating cells. SleB translocates across the...; Region: GH18_CFLE_spore_hydrolase; cd02874 991791005165 active site 991791005166 Acetyltransferase (GNAT) domain; Region: Acetyltransf_3; pfam13302 991791005167 Acetyltransferase (GNAT) family; Region: Acetyltransf_1; pfam00583 991791005168 ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132 991791005169 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 991791005170 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 991791005171 Walker A/P-loop; other site 991791005172 ATP binding site [chemical binding]; other site 991791005173 Q-loop/lid; other site 991791005174 ABC transporter signature motif; other site 991791005175 Walker B; other site 991791005176 D-loop; other site 991791005177 H-loop/switch region; other site 991791005178 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 991791005179 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 991791005180 non-specific DNA binding site [nucleotide binding]; other site 991791005181 salt bridge; other site 991791005182 sequence-specific DNA binding site [nucleotide binding]; other site 991791005183 Cro/C1-type HTH DNA-binding domain; Region: HTH_26; pfam13443 991791005184 Glycosyltransferases, probably involved in cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: COG1215 991791005185 CESA_CelA_like are involved in the elongation of the glucan chain of cellulose; Region: CESA_CelA_like; cd06421 991791005186 DXD motif; other site 991791005187 PilZ domain; Region: PilZ; pfam07238 991791005188 Cellulase (glycosyl hydrolase family 5); Region: Cellulase; pfam00150 991791005189 Predicted membrane protein involved in D-alanine export [Cell envelope biogenesis, outer membrane]; Region: DltB; COG1696 991791005190 DHHW protein; Region: DHHW; pfam14286 991791005191 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 991791005192 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 991791005193 metal binding site [ion binding]; metal-binding site 991791005194 active site 991791005195 I-site; other site 991791005196 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 991791005197 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 991791005198 metal binding site [ion binding]; metal-binding site 991791005199 active site 991791005200 I-site; other site 991791005201 helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347 991791005202 MarR family; Region: MarR; pfam01047 991791005203 Glutathione (GSH) peroxidase family; tetrameric selenoenzymes that catalyze the reduction of a variety of hydroperoxides including lipid peroxidases, using GSH as a specific electron donor substrate. GSH peroxidase contains one selenocysteine residue per...; Region: GSH_Peroxidase; cd00340 991791005204 catalytic residues [active] 991791005205 dimer interface [polypeptide binding]; other site 991791005206 Glutathione (GSH) peroxidase family; tetrameric selenoenzymes that catalyze the reduction of a variety of hydroperoxides including lipid peroxidases, using GSH as a specific electron donor substrate. GSH peroxidase contains one selenocysteine residue per...; Region: GSH_Peroxidase; cd00340 991791005207 catalytic residues [active] 991791005208 dimer interface [polypeptide binding]; other site 991791005209 Firmicute fructose-1,6-bisphosphatase; Region: FBPase_2; pfam06874 991791005210 Protein of unknown function (DUF2992); Region: DUF2992; pfam11208 991791005211 Alcohol dehydrogenase, class IV [Energy production and conversion]; Region: EutG; COG1454 991791005212 Dehydroquinate synthase-like (DHQ-like) and iron-containing alcohol dehydrogenases (Fe-ADH); Region: DHQ_Fe-ADH; cl02872 991791005213 active site 991791005214 NAD binding site [chemical binding]; other site 991791005215 metal binding site [ion binding]; metal-binding site 991791005216 conserved hypothetical protein; Region: TIGR02328 991791005217 Pyrimidine dimer DNA glycosylase; Region: Pyr_excise; pfam03013 991791005218 short chain dehydrogenase; Provisional; Region: PRK06701 991791005219 classical (c) SDR, subgroup 1; Region: SDR_c1; cd05355 991791005220 NAD binding site [chemical binding]; other site 991791005221 metal binding site [ion binding]; metal-binding site 991791005222 active site 991791005223 Uncharacterized BCR, COG1636; Region: DUF208; pfam02677 991791005224 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 991791005225 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 991791005226 non-specific DNA binding site [nucleotide binding]; other site 991791005227 salt bridge; other site 991791005228 sequence-specific DNA binding site [nucleotide binding]; other site 991791005229 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 991791005230 Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer); Region: MA; smart00283 991791005231 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 991791005232 dimer interface [polypeptide binding]; other site 991791005233 putative CheW interface [polypeptide binding]; other site 991791005234 Response regulator of the LytR/AlgR family [Transcription / Signal transduction mechanisms]; Region: LytT; COG3279 991791005235 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 991791005236 active site 991791005237 phosphorylation site [posttranslational modification] 991791005238 intermolecular recognition site; other site 991791005239 dimerization interface [polypeptide binding]; other site 991791005240 LytTr DNA-binding domain; Region: LytTR; pfam04397 991791005241 Predicted signal transduction protein with a C-terminal ATPase domain [Signal transduction mechanisms]; Region: COG2972 991791005242 Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase; Region: HATPase_c; pfam02518 991791005243 AAA domain; Region: AAA_17; pfam13207 991791005244 AAA domain; Region: AAA_18; pfam13238 991791005245 ribonuclease Z; Region: RNase_Z; TIGR02651 991791005246 Permeases of the major facilitator superfamily [General function prediction only]; Region: COG2270 991791005247 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 991791005248 putative substrate translocation pore; other site 991791005249 Integral membrane protein possibly involved in chromosome condensation [Cell division and chromosome partitioning]; Region: CrcB; COG0239 991791005250 camphor resistance protein CrcB; Provisional; Region: PRK14232 991791005251 Transcriptional regulator [Transcription]; Region: LysR; COG0583 991791005252 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 991791005253 The substrate binding domain of LysR-type transcriptional regulator MleR which required for malolactic fermentation, contains type 2 periplasmic binidning fold; Region: PBP2_MleR; cd08437 991791005254 putative dimerization interface [polypeptide binding]; other site 991791005255 malate dehydrogenase; Provisional; Region: PRK13529 991791005256 Malic enzyme, N-terminal domain; Region: malic; pfam00390 991791005257 NAD(P) binding domain of malic enzyme (ME), subgroup 1; Region: NAD_bind_1_malic_enz; cd05312 991791005258 NAD(P) binding site [chemical binding]; other site 991791005259 Di- and tricarboxylate transporters [Inorganic ion transport and metabolism]; Region: CitT; COG0471 991791005260 Anion permease ArsB/NhaD. These permeases have been shown to translocate sodium, arsenate, antimonite, sulfate and organic anions across biological membranes in all three kingdoms of life. A typical anion permease contains 8-13 transmembrane helices...; Region: ArsB_NhaD_permease; cd00625 991791005261 transmembrane helices; other site 991791005262 Predicted membrane protein [Function unknown]; Region: COG3689 991791005263 Predicted permeases [General function prediction only]; Region: COG0701 991791005264 ABC-type metal ion transport system, periplasmic component/surface adhesin [Inorganic ion transport and metabolism]; Region: LraI; COG0803 991791005265 Metal binding protein AcdA. These proteins have been shown to function in the ABC uptake of Zn2+ and Mn2+ and in competence for genetic transformation and adhesion. The AcdA proteins belong to the TroA superfamily of helical backbone metal receptor...; Region: AdcA; cd01017 991791005266 metal binding site [ion binding]; metal-binding site 991791005267 30S ribosomal protein S4; Validated; Region: rpsD; PRK05327 991791005268 Ribosomal protein S4/S9 N-terminal domain; Region: Ribosomal_S4; pfam00163 991791005269 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 991791005270 RNA binding surface [nucleotide binding]; other site 991791005271 INT_SG3, DNA breaking-rejoining enzymes, integrase/recombinases subgroup 3, catalytic domain. The CD contains various predicted bacterial and phage integrase/recombinase sequences for which not much experimental characterization is available; Region: INT_SG3_C; cd01186 991791005272 Int/Topo IB signature motif; other site 991791005273 malate dehydrogenase; Provisional; Region: PRK13529 991791005274 Malic enzyme, N-terminal domain; Region: malic; pfam00390 991791005275 NAD(P) binding domain of malic enzyme (ME), subgroup 1; Region: NAD_bind_1_malic_enz; cd05312 991791005276 NAD(P) binding site [chemical binding]; other site 991791005277 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3677 991791005278 Cache domain; Region: Cache_1; pfam02743 991791005279 Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer); Region: MA; smart00283 991791005280 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 991791005281 dimer interface [polypeptide binding]; other site 991791005282 putative CheW interface [polypeptide binding]; other site 991791005283 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 991791005284 dimer interface [polypeptide binding]; other site 991791005285 Methyl-accepting chemotaxis protein [Cell motility and secretion / Signal transduction mechanisms]; Region: Tar; COG0840 991791005286 putative CheW interface [polypeptide binding]; other site 991791005287 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4378 991791005288 2'-5' RNA ligase [Translation, ribosomal structure and biogenesis]; Region: LigT; COG1514 991791005289 LigT like Phosphoesterase; Region: LigT_PEase; pfam02834 991791005290 Methylglyoxal synthase catalyzes the enolization of dihydroxyacetone phosphate (DHAP) to produce methylglyoxal. The first part of the catalytic mechanism is believed to be similar to TIM (triosephosphate isomerase) in that both enzymes utilize DHAP to...; Region: MGS; cd01422 991791005291 active site 991791005292 dimer interfaces [polypeptide binding]; other site 991791005293 catalytic residues [active] 991791005294 Ketopantoate reductase PanE/ApbA; Region: ApbA; pfam02558 991791005295 2-dehydropantoate 2-reductase; Region: apbA_panE; TIGR00745 991791005296 Ketopantoate reductase PanE/ApbA C terminal; Region: ApbA_C; pfam08546 991791005297 Uncharacterized conserved protein [Function unknown]; Region: COG2454 991791005298 Domain of Unknown Function (DUF1599); Region: DUF1599; pfam07659 991791005299 Diadenosine tetraphosphate (Ap4A) hydrolase and other HIT family hydrolases [Nucleotide transport and metabolism / Carbohydrate transport and metabolism / General function prediction only]; Region: Hit; COG0537 991791005300 nucleotide binding site/active site [active] 991791005301 HIT family signature motif; other site 991791005302 catalytic residue [active] 991791005303 Transcription elongation factor Elf1 like; Region: Elf1; cl02038 991791005304 Branched-chain amino acid transport protein; Region: Branch_AA_trans; pfam05525 991791005305 MATE family multidrug exporter; Provisional; Region: PRK10189 991791005306 Subfamily of the multidrug and toxic compound extrusion (MATE)-like proteins similar to Thermotoga marina NorM; Region: MATE_NorM_like; cd13137 991791005307 ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132 991791005308 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 991791005309 ATP-binding cassette domain of the bacterial lipid flippase and related proteins, subfamily C; Region: ABCC_MsbA; cd03251 991791005310 Walker A/P-loop; other site 991791005311 ATP binding site [chemical binding]; other site 991791005312 Q-loop/lid; other site 991791005313 ABC transporter signature motif; other site 991791005314 Walker B; other site 991791005315 D-loop; other site 991791005316 H-loop/switch region; other site 991791005317 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394 991791005318 active site 991791005319 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394 991791005320 active site 991791005321 Glycosyltransferase like family 2; Region: Glyco_tranf_2_3; pfam13641 991791005322 Small, acid-soluble spore proteins, alpha/beta type; Region: SASP; pfam00269 991791005323 Fe-S oxidoreductases [Energy production and conversion]; Region: COG0731 991791005324 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 991791005325 FeS/SAM binding site; other site 991791005326 Pyridoxal kinase plays a key role in the synthesis of the active coenzyme pyridoxal-5'-phosphate (PLP), by catalyzing the phosphorylation of the precursor vitamin B6 in the presence of Zn2+ and ATP. Mammals are unable to synthesize PLP de novo and...; Region: pyridoxal_pyridoxamine_kinase; cd01173 991791005327 dimer interface [polypeptide binding]; other site 991791005328 pyridoxal binding site [chemical binding]; other site 991791005329 ATP binding site [chemical binding]; other site 991791005330 Uncharacterized ACR, YkgG family COG1556; Region: DUF162; pfam02589 991791005331 EDD domain protein, DegV family; Region: DegV; TIGR00762 991791005332 Uncharacterized protein, DegV family COG1307; Region: DegV; pfam02645 991791005333 Uncharacterized conserved protein [Function unknown]; Region: COG4359 991791005334 Glycerol dehydrogenase and related enzymes [Energy production and conversion]; Region: GldA; COG0371 991791005335 Glycerol-1-phosphate_dehydrogenase and related proteins; Region: G1PDH_related; cd08549 991791005336 active site 991791005337 metal binding site [ion binding]; metal-binding site 991791005338 Type IIA topoisomerase (DNA gyrase/topo II, topoisomerase IV), B subunit [DNA replication, recombination, and repair]; Region: GyrB; COG0187 991791005339 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 991791005340 ATP binding site [chemical binding]; other site 991791005341 Mg2+ binding site [ion binding]; other site 991791005342 G-X-G motif; other site 991791005343 TopoIIA_Trans_DNA_gyrase: Transducer domain, having a ribosomal S5 domain 2-like fold, of the type found in proteins of the type IIA family of DNA topoisomerases similar to the B subunits of E. coli DNA gyrase and E. coli Topoisomerase IV which are; Region: TopoII_Trans_DNA_gyrase; cd00822 991791005344 anchoring element; other site 991791005345 dimer interface [polypeptide binding]; other site 991791005346 ATP binding site [chemical binding]; other site 991791005347 Topoisomerase-primase domain. This is a nucleotidyl transferase/hydrolase domain found in type IA, type IIA and type IIB topoisomerases, bacterial DnaG-type primases, small primase-like proteins from bacteria and archaea, OLD family nucleases from...; Region: TOPRIM; cl00718 991791005348 active site 991791005349 metal binding site [ion binding]; metal-binding site 991791005350 DNA gyrase B subunit, carboxyl terminus; Region: DNA_gyraseB_C; pfam00986 991791005351 DNA topoisomerase IV subunit A; Provisional; Region: PRK13979 991791005352 DNA Topoisomerase, subtype IIA; domain A'; bacterial DNA topoisomerase IV (C subunit, ParC), bacterial DNA gyrases (A subunit, GyrA),mammalian DNA toposiomerases II. DNA topoisomerases are essential enzymes that regulate the conformational changes...; Region: TOP4c; cd00187 991791005353 CAP-like domain; other site 991791005354 active site 991791005355 primary dimer interface [polypeptide binding]; other site 991791005356 DJ-1 family protein; Region: not_thiJ; TIGR01383 991791005357 Type 1 glutamine amidotransferase (GATase1)-like domain found in Human DJ-1; Region: GATase1_DJ-1; cd03135 991791005358 conserved cys residue [active] 991791005359 Predicted Zn-dependent peptidases [General function prediction only]; Region: PqqL; COG0612 991791005360 Insulinase (Peptidase family M16); Region: Peptidase_M16; pfam00675 991791005361 Peptidase M16 inactive domain; Region: Peptidase_M16_C; pfam05193 991791005362 biotin synthase; Provisional; Region: PRK07094 991791005363 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 991791005364 FeS/SAM binding site; other site 991791005365 Biotin and Thiamin Synthesis associated domain; Region: BATS; cl06149 991791005366 Endonuclease IV [DNA replication, recombination, and repair]; Region: Nfo; COG0648 991791005367 AP endonuclease family 2; These endonucleases play a role in DNA repair. Cleave phosphodiester bonds at apurinic or apyrimidinic sites; the alignment also contains hexulose-6-phosphate isomerases, enzymes that catalyze the epimerization of...; Region: AP2Ec; cd00019 991791005368 AP (apurinic/apyrimidinic) site pocket; other site 991791005369 DNA interaction; other site 991791005370 Metal-binding active site; metal-binding site 991791005371 Uncharacterized conserved protein [Function unknown]; Region: COG1633 991791005372 Manganese catalase-like protein, ferritin-like diiron-binding domain; Region: Mn_catalase_like; cd07908 991791005373 dinuclear metal binding motif [ion binding]; other site 991791005374 flagellin; Provisional; Region: PRK12804 991791005375 Bacterial flagellin N-terminal helical region; Region: Flagellin_N; pfam00669 991791005376 Bacterial flagellin C-terminal helical region; Region: Flagellin_C; pfam00700 991791005377 Predicted RNA-bindining protein (contains S1 and HTH domains) [General function prediction only]; Region: COG2996 991791005378 S1 domain; Region: S1_2; pfam13509 991791005379 S1 domain; Region: S1_2; pfam13509 991791005380 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4495 991791005381 LXG domain of WXG superfamily; Region: LXG; pfam04740 991791005382 NAD+--asparagine ADP-ribosyltransferase [Signal transduction mechanisms]; Region: COG5585 991791005383 HNH/ENDO VII superfamily nuclease with conserved GHE residues; Region: GH-E; pfam14410 991791005384 ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other...; Region: ANK; cd00204 991791005385 Ankyrin repeats (3 copies); Region: Ank_2; pfam12796 991791005386 NAD+--asparagine ADP-ribosyltransferase [Signal transduction mechanisms]; Region: COG5585 991791005387 Uncharacterized conserved protein [Function unknown]; Region: COG5620 991791005388 GAD-like domain; Region: GAD-like; pfam08887 991791005389 Domain of unknown function (DUF1851); Region: DUF1851; pfam08906 991791005390 NAD+--asparagine ADP-ribosyltransferase [Signal transduction mechanisms]; Region: COG5585 991791005391 A nuclease family of the HNH/ENDO VII superfamily with conserved AHH; Region: AHH; pfam14412 991791005392 Ankyrin repeats (3 copies); Region: Ank_2; pfam12796 991791005393 ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other...; Region: ANK; cd00204 991791005394 Ankyrin repeats (3 copies); Region: Ank_2; pfam12796 991791005395 Ankyrin repeats (3 copies); Region: Ank_2; pfam12796 991791005396 Suppressor of fused protein (SUFU); Region: SUFU; pfam05076 991791005397 NAD+--asparagine ADP-ribosyltransferase [Signal transduction mechanisms]; Region: COG5585 991791005398 A nuclease of the HNH/ENDO VII superfamily with conserved WHH; Region: WHH; pfam14414 991791005399 Protein of unknown function (DUF2004); Region: DUF2004; pfam09406 991791005400 NAD+--asparagine ADP-ribosyltransferase [Signal transduction mechanisms]; Region: COG5585 991791005401 Uncharacterized conserved protein [Function unknown]; Region: COG5620 991791005402 Domain of unknown function (DUF1851); Region: DUF1851; pfam08906 991791005403 [FeFe] hydrogenase H-cluster maturation GTPase HydF; Region: GTP_HydF; TIGR03918 991791005404 E. coli Ras-like protein (Era)-like GTPase; Region: Era_like; cd00880 991791005405 G1 box; other site 991791005406 GTP/Mg2+ binding site [chemical binding]; other site 991791005407 Switch I region; other site 991791005408 G2 box; other site 991791005409 Switch II region; other site 991791005410 G3 box; other site 991791005411 G4 box; other site 991791005412 G5 box; other site 991791005413 aspartate ammonia-lyase; Provisional; Region: aspA; PRK12273 991791005414 Aspartase; Region: Aspartase; cd01357 991791005415 active sites [active] 991791005416 tetramer interface [polypeptide binding]; other site 991791005417 dolichyl-phosphate beta-D-mannosyltransferase; Region: PLN02726 991791005418 DPM1_like represents putative enzymes similar to eukaryotic DPM1; Region: DPM1_like; cd06442 991791005419 Ligand binding site; other site 991791005420 Putative Catalytic site; other site 991791005421 DXD motif; other site 991791005422 Predicted Zn-dependent peptidases, insulinase-like [General function prediction only]; Region: COG1026 991791005423 Peptidase M16 inactive domain; Region: Peptidase_M16_C; pfam05193 991791005424 Peptidase M16C associated; Region: M16C_assoc; pfam08367 991791005425 phosphoribosylformylglycinamidine synthase, clade II; Region: FGAM-synthase; TIGR01857 991791005426 AIR (aminoimidazole ribonucleotide) synthase related protein. This family includes Hydrogen expression/formation protein HypE, AIR synthases, FGAM (formylglycinamidine ribonucleotide) synthase and Selenophosphate synthetase (SelD). The N-terminal domain...; Region: PurM-like; cl10019 991791005427 PurL subunit of the formylglycinamide ribonucleotide amidotransferase (FGAR-AT), first repeat. FGAR-AT catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to formylglycinamidine ribonucleotide (FGAM), ADP; Region: PurL_repeat1; cd02203 991791005428 dimerization interface [polypeptide binding]; other site 991791005429 ATP binding site [chemical binding]; other site 991791005430 PurL subunit of the formylglycinamide ribonucleotide amidotransferase (FGAR-AT), second repeat. FGAR-AT catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to formylglycinamidine ribonucleotide (FGAM), ADP; Region: PurL_repeat2; cd02204 991791005431 dimerization interface [polypeptide binding]; other site 991791005432 ATP binding site [chemical binding]; other site 991791005433 Type 1 glutamine amidotransferase (GATase1)-like domain found in Formylglycinamide ribonucleotide amidotransferase; Region: GATase1_FGAR_AT; cd01740 991791005434 putative active site [active] 991791005435 catalytic triad [active] 991791005436 Pentapeptide repeats (9 copies); Region: Pentapeptide_4; pfam13599 991791005437 Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805 991791005438 Pentapeptide repeats (9 copies); Region: Pentapeptide_4; pfam13599 991791005439 Catalytic domain of EDTA-resistant nuclease Nuc from Salmonella typhimurium and similar proteins; Region: PLDc_Nuc; cd09170 991791005440 PLD-like domain; Region: PLDc_2; pfam13091 991791005441 putative active site [active] 991791005442 catalytic site [active] 991791005443 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cd00012 991791005444 nucleotide binding site [chemical binding]; other site 991791005445 Acetokinase family; Region: Acetate_kinase; cl17229 991791005446 Ribosomal protein L7/L12 [Translation, ribosomal structure and biogenesis]; Region: RplL; COG0222 991791005447 L11 interface [polypeptide binding]; other site 991791005448 putative EF-Tu interaction site [polypeptide binding]; other site 991791005449 putative EF-G interaction site [polypeptide binding]; other site 991791005450 small acid-soluble spore protein, H-type; Region: SASP_H; TIGR02861 991791005451 This is a family of oligosaccharide phosphorylases. It includes yeast and mammalian glycogen phosphorylases, plant starch/glucan phosphorylase, as well as the maltodextrin phosphorylases of bacteria. The members of this family catalyze the breakdown of...; Region: GT1_Glycogen_Phosphorylase; cd04300 991791005452 glycogen/starch/alpha-glucan phosphorylases; Region: P_ylase; TIGR02093 991791005453 homodimer interface [polypeptide binding]; other site 991791005454 active site pocket [active] 991791005455 Predicted amidohydrolase [General function prediction only]; Region: COG0388 991791005456 Nitrilase superfamily, including nitrile- or amide-hydrolyzing enzymes and amide-condensing enzymes; Region: nitrilase; cl11424 991791005457 active site 991791005458 catalytic triad [active] 991791005459 dimer interface [polypeptide binding]; other site 991791005460 Predicted membrane protein [Function unknown]; Region: COG4905 991791005461 Protein of unknown function (DUF1113); Region: DUF1113; pfam06541 991791005462 Predicted HD superfamily hydrolase [General function prediction only]; Region: COG1418 991791005463 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cl17215 991791005464 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 991791005465 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 991791005466 Carbon starvation protein CstA; Region: CstA; pfam02554 991791005467 Carbon starvation protein, predicted membrane protein [Signal transduction mechanisms]; Region: CstA; COG1966 991791005468 C-terminal domain on CstA (DUF4161); Region: DUF4161; pfam13722 991791005469 Response regulator of the LytR/AlgR family [Transcription / Signal transduction mechanisms]; Region: LytT; COG3279 991791005470 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 991791005471 active site 991791005472 phosphorylation site [posttranslational modification] 991791005473 intermolecular recognition site; other site 991791005474 dimerization interface [polypeptide binding]; other site 991791005475 LytTr DNA-binding domain; Region: LytTR; pfam04397 991791005476 ATPase related to the helicase subunit of the Holliday junction resolvase [DNA replication, recombination, and repair]; Region: MGS1; COG2256 991791005477 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 991791005478 Walker A motif; other site 991791005479 ATP binding site [chemical binding]; other site 991791005480 Walker B motif; other site 991791005481 arginine finger; other site 991791005482 MgsA AAA+ ATPase C terminal; Region: MgsA_C; pfam12002 991791005483 Rad3-related DNA helicases [Transcription / DNA replication, recombination, and repair]; Region: DinG; COG1199 991791005484 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cl17251 991791005485 DEAD_2; Region: DEAD_2; pfam06733 991791005486 Helicase C-terminal domain; Region: Helicase_C_2; pfam13307 991791005487 glutamate synthase subunit alpha; Provisional; Region: gltB; PRK11750 991791005488 Glutamine amidotransferases class-II (Gn-AT), glutamate synthase (GltS)-type. GltS is a homodimer that synthesizes L-glutamate from 2-oxoglutarate and L-glutamine, an important step in ammonia assimilation in bacteria, cyanobacteria and plants. The...; Region: GltS; cd00713 991791005489 active site 991791005490 dimer interface [polypeptide binding]; other site 991791005491 Glutamate synthase central domain; Region: Glu_syn_central; pfam04898 991791005492 Glutamate synthase (GltS) FMN-binding domain. GltS is a complex iron-sulfur flavoprotein that catalyzes the reductive synthesis of L-glutamate from 2-oxoglutarate and L-glutamine via intramolecular channelling of ammonia, a reaction in the plant, yeast...; Region: GltS_FMN; cd02808 991791005493 active site 991791005494 FMN binding site [chemical binding]; other site 991791005495 substrate binding site [chemical binding]; other site 991791005496 3Fe-4S cluster binding site [ion binding]; other site 991791005497 gltb_C. This domain is found at the C-terminus of the large subunit (gltB) of glutamate synthase (GltS). GltS encodes a complex iron-sulfur flavoprotein that catalyzes the synthesis of L-glutamate from L-glutamine and 2-oxoglutarate. It requires the...; Region: gltB_C; cd00982 991791005498 domain interface; other site 991791005499 glutamate synthase subunit beta; Reviewed; Region: gltD; PRK12810 991791005500 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450 991791005501 Predicted transcriptional regulator [Transcription]; Region: COG1959 991791005502 Transcriptional regulator; Region: Rrf2; cl17282 991791005503 PRC-barrel domain containing protein [General function prediction only]; Region: COG3881 991791005504 PRC-barrel domain; Region: PRC; pfam05239 991791005505 PRC-barrel domain; Region: PRC; pfam05239 991791005506 Predicted permease, member of the PurR regulon [General function prediction only]; Region: yhhT; COG0628 991791005507 Domain of unknown function DUF20; Region: UPF0118; pfam01594 991791005508 alanyl-tRNA synthetase; Reviewed; Region: alaS; PRK00252 991791005509 Alanyl-tRNA synthetase (AlaRS) class II core catalytic domain. AlaRS is a homodimer. It is responsible for the attachment of alanine to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for ATP-dependent...; Region: AlaRS_core; cd00673 991791005510 motif 1; other site 991791005511 active site 991791005512 motif 2; other site 991791005513 motif 3; other site 991791005514 Threonyl and Alanyl tRNA synthetase second additional domain; Region: tRNA_SAD; smart00863 991791005515 DHHA1 domain; Region: DHHA1; pfam02272 991791005516 hypothetical protein; Provisional; Region: PRK05473 991791005517 Holliday junction resolvase-like protein; Reviewed; Region: PRK00109 991791005518 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3906 991791005519 Ferric uptake regulator(Fur) and related metalloregulatory proteins; typically iron-dependent, DNA-binding repressors and activators; Region: Fur_like; cd07153 991791005520 metal binding site 2 [ion binding]; metal-binding site 991791005521 putative DNA binding helix; other site 991791005522 metal binding site 1 [ion binding]; metal-binding site 991791005523 dimer interface [polypeptide binding]; other site 991791005524 structural Zn2+ binding site [ion binding]; other site 991791005525 mRNA degradation ribonucleases J1/J2 (metallo-beta-lactamase superfamily) [Translation, ribosomal structure and biogenesis; Replication, recombination and repair]; Region: COG0595 991791005526 Metallo-beta-lactamase superfamily; Region: Lactamase_B; smart00849 991791005527 RNA-metabolising metallo-beta-lactamase; Region: RMMBL; pfam07521 991791005528 Predicted membrane GTPase involved in stress response [Signal transduction mechanisms]; Region: TypA; COG1217 991791005529 Tyrosine phosphorylated protein A (TypA)/BipA family belongs to ribosome-binding GTPases; Region: TypA_BipA; cd01891 991791005530 G1 box; other site 991791005531 putative GEF interaction site [polypeptide binding]; other site 991791005532 GTP/Mg2+ binding site [chemical binding]; other site 991791005533 Switch I region; other site 991791005534 G2 box; other site 991791005535 G3 box; other site 991791005536 Switch II region; other site 991791005537 G4 box; other site 991791005538 G5 box; other site 991791005539 BipA_TypA_II: domain II of BipA (also called TypA) having homology to domain II of the elongation factors (EFs) EF-G and EF-Tu. BipA is a highly conserved protein with global regulatory properties in Escherichia coli. BipA is phosphorylated on a...; Region: BipA_TypA_II; cd03691 991791005540 BipA_TypA_C: a C-terminal portion of BipA or TypA having homology to the C terminal domains of the elongation factors EF-G and EF-2. A member of the ribosome binding GTPase superfamily, BipA is widely distributed in bacteria and plants. BipA is a highly...; Region: BipA_TypA_C; cd03710 991791005541 YceG-like family; Region: YceG; pfam02618 991791005542 proteins similar to Escherichia coli yceG; Region: yceG_like; cd08010 991791005543 dimerization interface [polypeptide binding]; other site 991791005544 Predicted O-methyltransferase [General function prediction only]; Region: COG4122 991791005545 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 991791005546 S-adenosylmethionine binding site [chemical binding]; other site 991791005547 Collagenase and related proteases [Posttranslational modification, protein turnover, chaperones]; Region: COG0826 991791005548 DRE-TIM metallolyase superfamily; Region: DRE_TIM_metallolyase; cl07974 991791005549 Peptidase family U32; Region: Peptidase_U32; pfam01136 991791005550 Cell division protein FtsI/penicillin-binding protein 2 [Cell envelope biogenesis, outer membrane]; Region: FtsI; COG0768 991791005551 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; cl17760 991791005552 sporulation sigma factor SigK; Reviewed; Region: PRK05803 991791005553 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 991791005554 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 991791005555 DNA binding residues [nucleotide binding] 991791005556 Tfp pilus assembly protein, pilus retraction ATPase PilT [Cell motility and secretion / Intracellular trafficking and secretion]; Region: PilT; COG2805 991791005557 Pilus retraction ATPase PilT. PilT is a nucleotide binding protein responsible for the retraction of type IV pili, likely by pili disassembly. This retraction provides the force required for travel of bacteria in low water environments by a mechanism...; Region: PilT; cd01131 991791005558 Walker A motif; other site 991791005559 ATP binding site [chemical binding]; other site 991791005560 Walker B motif; other site 991791005561 Glycosyltransferases, probably involved in cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: COG1215 991791005562 EpsO protein participates in the methanolan synthesis; Region: EpsO_like; cd06438 991791005563 DXD motif; other site 991791005564 Cell division ATPase FtsA [Cell division and chromosome partitioning]; Region: ftsA; COG0849 991791005565 Cell division protein FtsA; Region: FtsA; smart00842 991791005566 Cell division protein FtsA; Region: FtsA; pfam14450 991791005567 cell division protein FtsZ; Validated; Region: PRK09330 991791005568 FtsZ is a GTPase that is similar to the eukaryotic tubulins and is essential for cell division in prokaryotes. FtsZ is capable of polymerizing in a GTP-driven process into structures similar to those formed by tubulin. FtsZ forms a ring-shaped septum at...; Region: FtsZ_type1; cd02201 991791005569 nucleotide binding site [chemical binding]; other site 991791005570 SulA interaction site; other site 991791005571 Sporulation factor SpoIIGA; Region: Peptidase_U4; pfam03419 991791005572 sigma-E processing peptidase SpoIIGA; Region: spore_II_GA; TIGR02854 991791005573 sporulation sigma factor SigE; Reviewed; Region: PRK08301 991791005574 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 991791005575 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 991791005576 DNA binding residues [nucleotide binding] 991791005577 sporulation sigma factor SigG; Reviewed; Region: PRK08215 991791005578 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 991791005579 Sigma-70 region 3; Region: Sigma70_r3; pfam04539 991791005580 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 991791005581 DNA binding residues [nucleotide binding] 991791005582 Protein implicated in RNA metabolism, contains PRC-barrel domain [General function prediction only]; Region: COG1873; cl17889 991791005583 transcriptional regulator NrdR; Validated; Region: nrdR; PRK00464 991791005584 ATP cone domain; Region: ATP-cone; pfam03477 991791005585 Multicopper polyphenol oxidase (laccase) [Secondary metabolites biosynthesis, transport and catabolism]; Region: yfiH; COG1496 991791005586 Multi-copper polyphenol oxidoreductase laccase; Region: Cu-oxidase_4; pfam02578 991791005587 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 991791005588 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 991791005589 active site 991791005590 phosphorylation site [posttranslational modification] 991791005591 intermolecular recognition site; other site 991791005592 dimerization interface [polypeptide binding]; other site 991791005593 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 991791005594 DNA binding site [nucleotide binding] 991791005595 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 991791005596 dimerization interface [polypeptide binding]; other site 991791005597 phosphate regulon sensor kinase PhoR; Region: phoR_proteo; TIGR02966 991791005598 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 991791005599 putative active site [active] 991791005600 heme pocket [chemical binding]; other site 991791005601 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 991791005602 dimer interface [polypeptide binding]; other site 991791005603 phosphorylation site [posttranslational modification] 991791005604 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 991791005605 ATP binding site [chemical binding]; other site 991791005606 Mg2+ binding site [ion binding]; other site 991791005607 G-X-G motif; other site 991791005608 Cache domain; Region: Cache_1; pfam02743 991791005609 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 991791005610 putative CheW interface [polypeptide binding]; other site 991791005611 PBP superfamily domain; Region: PBP_like_2; cl17296 991791005612 Bacterial extracellular solute-binding protein; Region: SBP_bac_11; pfam13531 991791005613 phosphate ABC transporter, permease protein PstC; Region: phosphate_pstC; TIGR02138 991791005614 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 991791005615 dimer interface [polypeptide binding]; other site 991791005616 conserved gate region; other site 991791005617 putative PBP binding loops; other site 991791005618 ABC-ATPase subunit interface; other site 991791005619 ABC-type phosphate transport system, permease component [Inorganic ion transport and metabolism]; Region: PstA; COG0581 991791005620 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 991791005621 dimer interface [polypeptide binding]; other site 991791005622 conserved gate region; other site 991791005623 putative PBP binding loops; other site 991791005624 ABC-ATPase subunit interface; other site 991791005625 phosphate transporter ATP-binding protein; Provisional; Region: PRK14240 991791005626 ATP-binding cassette domain of the phosphate transport system; Region: ABC_PstB_phosphate_transporter; cd03260 991791005627 Walker A/P-loop; other site 991791005628 ATP binding site [chemical binding]; other site 991791005629 Q-loop/lid; other site 991791005630 ABC transporter signature motif; other site 991791005631 Walker B; other site 991791005632 D-loop; other site 991791005633 H-loop/switch region; other site 991791005634 phosphate transport system regulatory protein PhoU; Region: phoU_full; TIGR02135 991791005635 PhoU domain; Region: PhoU; pfam01895 991791005636 PhoU domain; Region: PhoU; pfam01895 991791005637 Fe-S oxidoreductase, related to NifB/MoaA family [Energy production and conversion]; Region: COG1625 991791005638 PDZ domain of tryspin-like serine proteases, such as DegP/HtrA, which are oligomeric proteins involved in heat-shock response, chaperone function, and apoptosis. May be responsible for substrate recognition and/or binding, as most PDZ domains bind...; Region: PDZ_serine_protease; cd00987 991791005639 Protein of unknown function (DUF512); Region: DUF512; pfam04459 991791005640 GTP-binding protein Der; Reviewed; Region: PRK00093 991791005641 EngA1 GTPase contains the first domain of EngA; Region: EngA1; cd01894 991791005642 G1 box; other site 991791005643 GTP/Mg2+ binding site [chemical binding]; other site 991791005644 Switch I region; other site 991791005645 G2 box; other site 991791005646 Switch II region; other site 991791005647 G3 box; other site 991791005648 G4 box; other site 991791005649 G5 box; other site 991791005650 EngA2 GTPase contains the second domain of EngA; Region: EngA2; cd01895 991791005651 G1 box; other site 991791005652 GTP/Mg2+ binding site [chemical binding]; other site 991791005653 Switch I region; other site 991791005654 G2 box; other site 991791005655 G3 box; other site 991791005656 Switch II region; other site 991791005657 G4 box; other site 991791005658 G5 box; other site 991791005659 NAD(P)H-dependent glycerol-3-phosphate dehydrogenase; Validated; Region: gpsA; PRK00094 991791005660 NAD-dependent glycerol-3-phosphate dehydrogenase N-terminus; Region: NAD_Gly3P_dh_N; pfam01210 991791005661 NAD-dependent glycerol-3-phosphate dehydrogenase C-terminus; Region: NAD_Gly3P_dh_C; pfam07479 991791005662 Stage IV sporulation protein A (spore_IV_A); Region: Spore_IV_A; pfam09547 991791005663 stage IV sporulation protein A; Region: spore_IV_A; TIGR02836 991791005664 Type II (periplasmic) bacterial L-asparaginase; Region: L-asparaginase_II; cd08964 991791005665 active site 991791005666 homotetramer interface [polypeptide binding]; other site 991791005667 homodimer interface [polypeptide binding]; other site 991791005668 LL-diaminopimelate aminotransferase; Provisional; Region: PRK09276 991791005669 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 991791005670 pyridoxal 5'-phosphate binding site [chemical binding]; other site 991791005671 homodimer interface [polypeptide binding]; other site 991791005672 catalytic residue [active] 991791005673 hypothetical protein; Provisional; Region: PRK11820 991791005674 YicC-like family, N-terminal region; Region: YicC_N; pfam03755 991791005675 Domain of unknown function (DUF1732); Region: DUF1732; pfam08340 991791005676 hypothetical protein; Provisional; Region: PRK04323 991791005677 Guanylate kinase [Nucleotide transport and metabolism]; Region: Gmk; COG0194 991791005678 Guanosine monophosphate kinase (GMPK, EC 2.7.4.8), also known as guanylate kinase (GKase), catalyzes the reversible phosphoryl transfer from adenosine triphosphate (ATP) to guanosine monophosphate (GMP) to yield adenosine diphosphate (ADP) and guanosine...; Region: GMPK; cd00071 991791005679 catalytic site [active] 991791005680 G-X2-G-X-G-K; other site 991791005681 DNA-directed RNA polymerase subunit omega; Reviewed; Region: rpoZ; PRK00392 991791005682 bifunctional phosphopantothenoylcysteine decarboxylase/phosphopantothenate synthase; Validated; Region: PRK05579 991791005683 Flavoprotein; Region: Flavoprotein; pfam02441 991791005684 DNA / pantothenate metabolism flavoprotein; Region: DFP; pfam04127 991791005685 primosome assembly protein PriA; Validated; Region: PRK05580 991791005686 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 991791005687 ATP binding site [chemical binding]; other site 991791005688 putative Mg++ binding site [ion binding]; other site 991791005689 helicase superfamily c-terminal domain; Region: HELICc; smart00490 991791005690 Polypeptide or peptide deformylase; a family of metalloenzymes that catalyzes the removal of the N-terminal formyl group in a growing polypeptide chain following translation initiation during protein synthesis in prokaryotes. These enzymes utilize Fe(II)...; Region: Pep_deformylase; cd00487 991791005691 active site 991791005692 catalytic residues [active] 991791005693 metal binding site [ion binding]; metal-binding site 991791005694 methionyl-tRNA formyltransferase; Reviewed; Region: fmt; PRK00005 991791005695 Methionyl-tRNA formyltransferase, N-terminal hydrolase domain; Region: FMT_core_Met-tRNA-FMT_N; cd08646 991791005696 putative active site [active] 991791005697 substrate binding site [chemical binding]; other site 991791005698 putative cosubstrate binding site; other site 991791005699 catalytic site [active] 991791005700 C-terminal domain of Formyltransferase and other enzymes; Region: Met_tRNA_FMT_C; cd08704 991791005701 substrate binding site [chemical binding]; other site 991791005702 Putative neutral zinc metallopeptidase; Region: Zn_peptidase_2; pfam04298 991791005703 16S rRNA methyltransferase B; Provisional; Region: PRK14902 991791005704 NusB family; Region: NusB; pfam01029 991791005705 putative RNA binding site [nucleotide binding]; other site 991791005706 NOL1/NOP2/sun family putative RNA methylase; Region: nop2p; TIGR00446 991791005707 ribosomal RNA large subunit methyltransferase N; Provisional; Region: PRK14454 991791005708 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 991791005709 FeS/SAM binding site; other site 991791005710 Serine/threonine phosphatases, family 2C, catalytic domain; The protein architecture and deduced catalytic mechanism of PP2C phosphatases are similar to the PP1, PP2A, PP2B family of protein Ser/Thr phosphatases, with which PP2C shares no sequence...; Region: PP2Cc; cd00143 991791005711 Protein phosphatase 2C; Region: PP2C; pfam00481 991791005712 active site 991791005713 Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220 991791005714 Catalytic domain of Protein Kinases; Region: PKc; cd00180 991791005715 active site 991791005716 ATP binding site [chemical binding]; other site 991791005717 substrate binding site [chemical binding]; other site 991791005718 activation loop (A-loop); other site 991791005719 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2815 991791005720 PASTA domain of bacterial serine/threonine kinase pknB-like proteins. PknB is a member of a group of related transmembrane sensor kinases present in many gram positive bacteria, which has been shown to regulate cell shape in Mycobacterium tubercolosis; Region: PASTA_pknB; cd06577 991791005721 PASTA domain of bacterial serine/threonine kinase pknB-like proteins. PknB is a member of a group of related transmembrane sensor kinases present in many gram positive bacteria, which has been shown to regulate cell shape in Mycobacterium tubercolosis; Region: PASTA_pknB; cd06577 991791005722 PASTA domain of bacterial serine/threonine kinase pknB-like proteins. PknB is a member of a group of related transmembrane sensor kinases present in many gram positive bacteria, which has been shown to regulate cell shape in Mycobacterium tubercolosis; Region: PASTA_pknB; cd06577 991791005723 GTPase RsgA; Reviewed; Region: PRK00098 991791005724 S1_YloQ_GTPase: YloQ GTase family (also known as YjeQ and CpgA), S1-like RNA-binding domain. Proteins in the YloQ GTase family bind the ribosome and have GTPase activity. The precise role of this family is unknown. The protein structure is composed of...; Region: S1_YloQ_GTPase; cd04466 991791005725 RNA binding site [nucleotide binding]; other site 991791005726 homodimer interface [polypeptide binding]; other site 991791005727 Ribosomal interacting GTPase YjeQ/EngC, a circularly permuted subfamily of the Ras GTPases; Region: YjeQ_EngC; cd01854 991791005728 GTPase/Zn-binding domain interface [polypeptide binding]; other site 991791005729 GTP/Mg2+ binding site [chemical binding]; other site 991791005730 G4 box; other site 991791005731 G5 box; other site 991791005732 G1 box; other site 991791005733 Switch I region; other site 991791005734 G2 box; other site 991791005735 G3 box; other site 991791005736 Switch II region; other site 991791005737 Pentose-5-phosphate-3-epimerase [Carbohydrate transport and metabolism]; Region: Rpe; COG0036 991791005738 Ribulose-5-phosphate 3-epimerase (RPE). This enzyme catalyses the interconversion of D-ribulose 5-phosphate (Ru5P) into D-xylulose 5-phosphate, as part of the Calvin cycle (reductive pentose phosphate pathway) in chloroplasts and in the oxidative pentose...; Region: RPE; cd00429 991791005739 substrate binding site [chemical binding]; other site 991791005740 hexamer interface [polypeptide binding]; other site 991791005741 metal binding site [ion binding]; metal-binding site 991791005742 Thiamine pyrophosphokinase [Coenzyme metabolism]; Region: THI80; COG1564 991791005743 Thiamine pyrophosphokinase; Region: TPK; cd07995 991791005744 active site 991791005745 dimerization interface [polypeptide binding]; other site 991791005746 thiamine binding site [chemical binding]; other site 991791005747 ribosomal protein L28; Region: L28; TIGR00009 991791005748 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG1302 991791005749 DAK2 domain fusion protein YloV; Region: YloV; TIGR03599 991791005750 DAK2 domain; Region: Dak2; pfam02734 991791005751 ATP-dependent DNA helicase RecG; Provisional; Region: PRK10917 991791005752 RecG_wedge_OBF: A subfamily of OB folds corresponding to the OB fold found in the N-terminal (wedge) domain of Escherichia coli RecG. RecG is a branched-DNA-specific helicase, which catalyzes the interconversion of a DNA replication fork to a...; Region: RecG_wedge_OBF; cd04488 991791005753 ssDNA binding site; other site 991791005754 generic binding surface II; other site 991791005755 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 991791005756 ATP binding site [chemical binding]; other site 991791005757 putative Mg++ binding site [ion binding]; other site 991791005758 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 991791005759 nucleotide binding region [chemical binding]; other site 991791005760 ATP-binding site [chemical binding]; other site 991791005761 Conserved hypothetical protein 95; Region: Cons_hypoth95; pfam03602 991791005762 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 991791005763 S-adenosylmethionine binding site [chemical binding]; other site 991791005764 phosphopantetheine adenylyltransferase; Provisional; Region: coaD; PRK00168 991791005765 Phosphopantetheine adenylyltransferase; Region: PPAT; cd02163 991791005766 active site 991791005767 (T/H)XGH motif; other site 991791005768 phosphodiesterase; Provisional; Region: PRK12704 991791005769 sporulation integral membrane protein YlbJ; Region: spore_ylbJ; TIGR02871 991791005770 hypothetical protein; Provisional; Region: PRK13670 991791005771 HIGH Nucleotidyl Transferase; Region: HIGH_NTase1; pfam05636 991791005772 phosphotransacetylase; Reviewed; Region: eutD; PRK09653 991791005773 propionate/acetate kinase; Provisional; Region: PRK12379 991791005774 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cd00012 991791005775 nucleotide binding site [chemical binding]; other site 991791005776 butyrate kinase; Provisional; Region: PRK03011 991791005777 Uncharacterized ACR, COG1399; Region: DUF177; pfam02620 991791005778 50S ribosomal protein L32; Reviewed; Region: rpmF; PRK12286 991791005779 putative phosphate acyltransferase; Provisional; Region: PRK05331 991791005780 acyl carrier protein; Provisional; Region: acpP; PRK00982 991791005781 ribonuclease III; Reviewed; Region: rnc; PRK00102 991791005782 RIBOc. Ribonuclease III C terminal domain. This group consists of eukaryotic, bacterial and archeal ribonuclease III (RNAse III) proteins. RNAse III is a double stranded RNA-specific endonuclease. Prokaryotic RNAse III is important in...; Region: RIBOc; cd00593 991791005783 dimerization interface [polypeptide binding]; other site 991791005784 active site 991791005785 metal binding site [ion binding]; metal-binding site 991791005786 Double-stranded RNA binding motif. Binding is not sequence specific but is highly specific for double stranded RNA. Found in a variety of proteins including dsRNA dependent protein kinase PKR, RNA helicases, Drosophila staufen protein, E. coli RNase III; Region: DSRM; cd00048 991791005787 dsRNA binding site [nucleotide binding]; other site 991791005788 Elongator protein 3, MiaB family, Radical SAM; Region: Elp3; smart00729 991791005789 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 991791005790 FeS/SAM binding site; other site 991791005791 Stage V sporulation protein S (SpoVS); Region: SpoVS; pfam04232 991791005792 Chromosome segregation ATPases [Cell division and chromosome partitioning]; Region: Smc; COG1196 991791005793 ATP-binding cassette domain of barmotin, a member of the SMC protein family; Region: ABC_SMC_barmotin; cd03278 991791005794 Walker A/P-loop; other site 991791005795 ATP binding site [chemical binding]; other site 991791005796 Q-loop/lid; other site 991791005797 SMC proteins Flexible Hinge Domain; Region: SMC_hinge; smart00968 991791005798 ATP-binding cassette domain of barmotin, a member of the SMC protein family; Region: ABC_SMC_barmotin; cd03278 991791005799 ABC transporter signature motif; other site 991791005800 Walker B; other site 991791005801 D-loop; other site 991791005802 H-loop/switch region; other site 991791005803 signal recognition particle-docking protein FtsY; Provisional; Region: PRK10416 991791005804 The signal recognition particle (SRP) mediates the transport to or across the plasma membrane in bacteria and the endoplasmic reticulum in eukaryotes. SRP recognizes N-terminal sighnal sequences of newly synthesized polypeptides at the ribosome. The...; Region: SRP; cd03115 991791005805 P loop; other site 991791005806 GTP binding site [chemical binding]; other site 991791005807 putative DNA-binding protein; Validated; Region: PRK00118 991791005808 Putative helix-turn-helix protein, YlxM / p13 like; Region: UPF0122; pfam04297 991791005809 signal recognition particle protein; Provisional; Region: PRK10867 991791005810 SRP54-type protein, helical bundle domain; Region: SRP54_N; smart00963 991791005811 The signal recognition particle (SRP) mediates the transport to or across the plasma membrane in bacteria and the endoplasmic reticulum in eukaryotes. SRP recognizes N-terminal sighnal sequences of newly synthesized polypeptides at the ribosome. The...; Region: SRP; cd03115 991791005812 P loop; other site 991791005813 GTP binding site [chemical binding]; other site 991791005814 Signal peptide binding domain; Region: SRP_SPB; pfam02978 991791005815 30S ribosomal protein S16; Reviewed; Region: rpsP; PRK00040 991791005816 Predicted RNA-binding protein (contains KH domain) [General function prediction only]; Region: COG1837 991791005817 hypothetical protein; Provisional; Region: PRK00468 991791005818 G-X-X-G motif; other site 991791005819 16S rRNA-processing protein RimM; Provisional; Region: rimM; PRK00122 991791005820 RimM N-terminal domain; Region: RimM; pfam01782 991791005821 PRC-barrel domain; Region: PRC; pfam05239 991791005822 tRNA (guanine-N(1)-)-methyltransferase; Reviewed; Region: trmD; PRK00026 991791005823 50S ribosomal protein L19; Provisional; Region: rplS; PRK05338 991791005824 signal peptidase I, bacterial type; Region: sigpep_I_bact; TIGR02227 991791005825 The S26 Type I signal peptidase (SPase; LepB; leader peptidase B; leader peptidase I; EC 3.4.21.89) family members are essential membrane-bound serine proteases that function to cleave the amino-terminal signal peptide extension from proteins that are...; Region: S26_SPase_I; cd06530 991791005826 Catalytic site [active] 991791005827 GTPase YlqF; Reviewed; Region: rbgA; PRK09563 991791005828 Circularly permuted YlqF GTPase; Region: YlqF; cd01856 991791005829 GTP/Mg2+ binding site [chemical binding]; other site 991791005830 G4 box; other site 991791005831 G5 box; other site 991791005832 Rat sarcoma (Ras)-like superfamily of small guanosine triphosphatases (GTPases); Region: Ras_like_GTPase; cl17170 991791005833 G1 box; other site 991791005834 G1 box; other site 991791005835 GTP/Mg2+ binding site [chemical binding]; other site 991791005836 Switch I region; other site 991791005837 G2 box; other site 991791005838 G2 box; other site 991791005839 Switch I region; other site 991791005840 G3 box; other site 991791005841 G3 box; other site 991791005842 Switch II region; other site 991791005843 Switch II region; other site 991791005844 G4 box; other site 991791005845 bacterial Ribonuclease HII-like; Region: RNase_HII_bacteria_HII_like; cd07182 991791005846 RNA/DNA hybrid binding site [nucleotide binding]; other site 991791005847 active site 991791005848 hypothetical protein; Reviewed; Region: PRK12497 991791005849 Predicted glutamine amidotransferases [General function prediction only]; Region: COG2071 991791005850 Subgroup of proteins having the Type 1 glutamine amidotransferase (GATase1) domain; Region: GATase1_2; cd01745 991791005851 catalytic triad [active] 991791005852 Predicted ATPase with chaperone activity [Posttranslational modification, protein turnover, chaperones]; Region: COG0606 991791005853 Subunit ChlI of Mg-chelatase; Region: ChlI; pfam13541 991791005854 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 991791005855 Walker A motif; other site 991791005856 ATP binding site [chemical binding]; other site 991791005857 Walker B motif; other site 991791005858 Magnesium chelatase, subunit ChlI; Region: Mg_chelatase_2; pfam13335 991791005859 RNA polymerase factor sigma-70; Validated; Region: PRK06811 991791005860 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 991791005861 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 991791005862 DNA binding residues [nucleotide binding] 991791005863 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3735 991791005864 RNA polymerase sigma-I factor; Region: spore_sigI; TIGR02895 991791005865 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 991791005866 Anti-sigma factor N-terminus; Region: RsgI_N; pfam12791 991791005867 Glycosyl hydrolase family 68, includes levansucrase, beta-fructofuranosidase and inulosucrase; Region: GH68; cd08997 991791005868 active site 991791005869 Beta-fructosidases (levanase/invertase) [Carbohydrate transport and metabolism]; Region: SacC; COG1621 991791005870 Glycosyl hydrolase family 32, beta-fructosidases; Region: GH32_B_Fructosidase; cd08996 991791005871 substrate binding [chemical binding]; other site 991791005872 active site 991791005873 Glycosyl hydrolases family 32 C terminal; Region: Glyco_hydro_32C; pfam08244 991791005874 Glycosyl hydrolase family 68, includes levansucrase, beta-fructofuranosidase and inulosucrase; Region: GH68; cd08997 991791005875 active site 991791005876 Predicted hydrolase (HAD superfamily) [General function prediction only]; Region: COG1011 991791005877 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 991791005878 motif II; other site 991791005879 ADP-ribose pyrophosphatase [Nucleotide transport and metabolism]; Region: COG1051 991791005880 nudix motif; other site 991791005881 nudix motif; other site 991791005882 Uncharacterized conserved protein [General function prediction only]; Region: COG4111 991791005883 Isochorismatase family; Region: Isochorismatase; pfam00857 991791005884 Cysteine hydrolases; This family contains amidohydrolases, like CSHase (N-carbamoylsarcosine amidohydrolase), involved in creatine metabolism and nicotinamidase, converting nicotinamide to nicotinic acid and ammonia in the pyridine nucleotide cycle. It...; Region: cysteine_hydrolases; cd00431 991791005885 catalytic triad [active] 991791005886 conserved cis-peptide bond; other site 991791005887 ABC-2 type transporter; Region: ABC2_membrane; cl17235 991791005888 nicotinate phosphoribosyltransferase; Validated; Region: PRK09243 991791005889 Nicotinate phosphoribosyltransferase (NAPRTase), subgroup A. Nicotinate phosphoribosyltransferase catalyses the formation of NAMN and PPi from 5-phosphoribosy -1-pyrophosphate (PRPP) and nicotinic acid, this is the first, and also rate limiting, reaction...; Region: NAPRTase_A; cd01570 991791005890 active site 991791005891 Nicotinamide/nicotinate mononucleotide adenylyltransferase; Region: NMNAT; cd02165 991791005892 nicotinate (nicotinamide) nucleotide adenylyltransferase; Region: TIGR00482 991791005893 active site 991791005894 (T/H)XGH motif; other site 991791005895 NAD synthetase; Reviewed; Region: nadE; PRK02628 991791005896 Glutamine aminotransferase (GAT, glutaminase) domain of glutamine-dependent NAD synthetases (class 7 and 8 nitrilases); Region: GAT_Gln-NAD-synth; cd07570 991791005897 multimer interface [polypeptide binding]; other site 991791005898 active site 991791005899 catalytic triad [active] 991791005900 protein interface 1 [polypeptide binding]; other site 991791005901 NAD+ synthase is a homodimer, which catalyzes the final step in de novo nicotinamide adenine dinucleotide (NAD+) biosynthesis, an amide transfer from either ammonia or glutamine to nicotinic acid adenine dinucleotide (NaAD). The conversion of NaAD to NAD...; Region: NAD_synthase; cd00553 991791005902 homodimer interface [polypeptide binding]; other site 991791005903 NAD binding pocket [chemical binding]; other site 991791005904 ATP binding pocket [chemical binding]; other site 991791005905 Mg binding site [ion binding]; other site 991791005906 active-site loop [active] 991791005907 Na+/H+-dicarboxylate symporters [Energy production and conversion]; Region: GltP; COG1301 991791005908 Sodium:dicarboxylate symporter family; Region: SDF; cl00573 991791005909 Predicted Rossmann fold nucleotide-binding protein involved in DNA uptake [DNA replication, recombination, and repair / Intracellular trafficking and secretion]; Region: Smf; COG0758 991791005910 DNA protecting protein DprA; Region: dprA; TIGR00732 991791005911 DNA topoisomerase I; Validated; Region: PRK05582 991791005912 TOPRIM_TopoIA_TopoI: The topoisomerase-primase (TORPIM) domain found in members of the type IA family of DNA topoisomerases (Topo IA) similar to Escherichia coli DNA topoisomerase I. Type IA DNA topoisomerases remove (relax) negative supercoils in the...; Region: TOPRIM_TopoIA_TopoI; cd03363 991791005913 active site 991791005914 interdomain interaction site; other site 991791005915 putative metal-binding site [ion binding]; other site 991791005916 nucleotide binding site [chemical binding]; other site 991791005917 DNA Topoisomerase, subtype IA; DNA-binding, ATP-binding and catalytic domain of bacterial DNA topoisomerases I and III, and eukaryotic DNA topoisomerase III and eubacterial and archael reverse gyrases. Topoisomerases clevage single or double stranded DNA...; Region: TOP1Ac; cd00186 991791005918 domain I; other site 991791005919 DNA binding groove [nucleotide binding] 991791005920 phosphate binding site [ion binding]; other site 991791005921 domain II; other site 991791005922 domain III; other site 991791005923 nucleotide binding site [chemical binding]; other site 991791005924 catalytic site [active] 991791005925 domain IV; other site 991791005926 Topoisomerase DNA binding C4 zinc finger; Region: zf-C4_Topoisom; pfam01396 991791005927 Topoisomerase DNA binding C4 zinc finger; Region: zf-C4_Topoisom; pfam01396 991791005928 Topoisomerase DNA binding C4 zinc finger; Region: zf-C4_Topoisom; pfam01396 991791005929 transcriptional repressor CodY; Validated; Region: PRK04158 991791005930 CodY GAF-like domain; Region: CodY; pfam06018 991791005931 CodY helix-turn-helix domain; Region: HTH_CodY; pfam08222 991791005932 Ribosomal protein S2 (RPS2), involved in formation of the translation initiation complex, where it might contact the messenger RNA and several components of the ribosome. It has been shown that in Escherichia coli RPS2 is essential for the binding of...; Region: RPS2; cd01425 991791005933 rRNA interaction site [nucleotide binding]; other site 991791005934 S8 interaction site; other site 991791005935 putative laminin-1 binding site; other site 991791005936 elongation factor Ts; Provisional; Region: tsf; PRK09377 991791005937 UBA/TS-N domain; Region: UBA; pfam00627 991791005938 Elongation factor TS; Region: EF_TS; pfam00889 991791005939 Elongation factor TS; Region: EF_TS; pfam00889 991791005940 UMP kinase (UMPK)-Ec, the microbial/chloroplast uridine monophosphate kinase (uridylate kinase) enzyme that catalyzes UMP phosphorylation and plays a key role in pyrimidine nucleotide biosynthesis; regulation of this process is via feed-back control and...; Region: AAK_UMPK-PyrH-Ec; cd04254 991791005941 putative nucleotide binding site [chemical binding]; other site 991791005942 uridine monophosphate binding site [chemical binding]; other site 991791005943 homohexameric interface [polypeptide binding]; other site 991791005944 ribosome recycling factor; Reviewed; Region: frr; PRK00083 991791005945 Ribosome recycling factor (RRF). Ribosome recycling factor dissociates the posttermination complex, composed of the ribosome, deacylated tRNA, and mRNA, after termination of translation. Thus ribosomes are "recycled" and ready for another...; Region: RRF; cd00520 991791005946 hinge region; other site 991791005947 undecaprenyl pyrophosphate synthase; Provisional; Region: PRK14830 991791005948 Undecaprenyl pyrophosphate synthase [Lipid metabolism]; Region: UppS; COG0020 991791005949 catalytic residue [active] 991791005950 putative FPP diphosphate binding site; other site 991791005951 putative FPP binding hydrophobic cleft; other site 991791005952 dimer interface [polypeptide binding]; other site 991791005953 putative IPP diphosphate binding site; other site 991791005954 CDP-diglyceride synthetase [Lipid metabolism]; Region: CdsA; COG0575 991791005955 Cytidylyltransferase family; Region: CTP_transf_1; pfam01148 991791005956 SOS-response transcriptional repressors (RecA-mediated autopeptidases) [Transcription / Signal transduction mechanisms]; Region: LexA; COG1974 991791005957 Peptidase S24 LexA-like proteins are involved in the SOS response leading to the repair of single-stranded DNA within the bacterial cell. This family includes: the lambda repressor CI/C2 family and related bacterial prophage repressor proteins; LexA (EC...; Region: S24_LexA-like; cd06529 991791005958 Catalytic site [active] 991791005959 Domain of unknown function DUF20; Region: UPF0118; pfam01594 991791005960 Predicted permease, member of the PurR regulon [General function prediction only]; Region: yhhT; COG0628 991791005961 1-deoxy-D-xylulose 5-phosphate reductoisomerase; Provisional; Region: PRK05447 991791005962 1-deoxy-D-xylulose 5-phosphate reductoisomerase; Region: DXP_reductoisom; pfam02670 991791005963 1-deoxy-D-xylulose 5-phosphate reductoisomerase C-terminal; Region: DXP_redisom_C; pfam08436 991791005964 DXP reductoisomerase C-terminal domain; Region: DXPR_C; pfam13288 991791005965 Predicted membrane-associated Zn-dependent proteases 1 [Cell envelope biogenesis, outer membrane]; Region: COG0750 991791005966 RseP-like Site-2 proteases (S2P), zinc metalloproteases (MEROPS family M50A), cleave transmembrane domains of substrate proteins, regulating intramembrane proteolysis (RIP) of diverse signal transduction mechanisms. In Escherichia coli, the S2P homolog...; Region: S2P-M50_PDZ_RseP-like; cd06163 991791005967 active site 991791005968 PDZ domain of bacterial and plant zinc metalloprotases, presumably membrane-associated or integral membrane proteases, which may be involved in signalling and regulatory mechanisms. May be responsible for substrate recognition and/or binding, as most PDZ...; Region: PDZ_metalloprotease; cd00989 991791005969 protein binding site [polypeptide binding]; other site 991791005970 RseP-like Site-2 proteases (S2P), zinc metalloproteases (MEROPS family M50A), cleave transmembrane domains of substrate proteins, regulating intramembrane proteolysis (RIP) of diverse signal transduction mechanisms. In Escherichia coli, the S2P homolog...; Region: S2P-M50_PDZ_RseP-like; cd06163 991791005971 putative substrate binding region [chemical binding]; other site 991791005972 4-hydroxy-3-methylbut-2-en-1-yl diphosphate synthase; Reviewed; Region: ispG; PRK00366 991791005973 4-hydroxy-3-methylbut-2-en-1-yl diphosphate synthase; Validated; Region: PRK00694 991791005974 4-hydroxy-3-methylbut-2-en-1-yl diphosphate synthase; Validated; Region: PRK00694 991791005975 ribosome maturation protein RimP; Reviewed; Region: PRK00092 991791005976 Sm and related proteins; Region: Sm_like; cl00259 991791005977 Bacillus subtilis YxlS-like, C-terminal domain; Region: YlxS_C; cd01734 991791005978 putative oligomer interface [polypeptide binding]; other site 991791005979 putative RNA binding site [nucleotide binding]; other site 991791005980 transcription elongation factor NusA; Provisional; Region: nusA; PRK12327 991791005981 NusA N-terminal domain; Region: NusA_N; pfam08529 991791005982 S1_NusA: N-utilizing substance A protein (NusA), S1-like RNA-binding domain. S1-like RNA-binding domains are found in a wide variety of RNA-associated proteins. NusA is a transcription elongation factor containing an N-terminal catalytic domain and three...; Region: S1_NusA; cd04455 991791005983 RNA binding site [nucleotide binding]; other site 991791005984 homodimer interface [polypeptide binding]; other site 991791005985 NusA-like KH domain; Region: KH_5; pfam13184 991791005986 NusA_K homology RNA-binding domain (KH). NusA is an essential multifunctional transcription elongation factor that is universally conserved among prokaryotes and archaea. NusA anti-termination function plays an important role in the expression of...; Region: NusA_KH; cd02134 991791005987 G-X-X-G motif; other site 991791005988 Ylxr homologs; group of conserved hypothetical bacterial proteins of unknown function; structure revealed putative RNA binding cleft; proteins are encoded by an operon that includes other proteins involved in transcription and/or translation; Region: YlxR; cd00279 991791005989 putative RNA binding cleft [nucleotide binding]; other site 991791005990 ribosomal protein L7Ae family protein; Provisional; Region: PRK05583 991791005991 Translation initiation factor IF-2, N-terminal region; Region: IF2_N; pfam04760 991791005992 Translation initiation factor IF-2, N-terminal region; Region: IF2_N; pfam04760 991791005993 translation initiation factor IF-2; Region: IF-2; TIGR00487 991791005994 Initiation Factor 2 (IF2)/ eukaryotic Initiation Factor 5B (eIF5B) family; Region: IF2_eIF5B; cd01887 991791005995 G1 box; other site 991791005996 putative GEF interaction site [polypeptide binding]; other site 991791005997 GTP/Mg2+ binding site [chemical binding]; other site 991791005998 Switch I region; other site 991791005999 G2 box; other site 991791006000 G3 box; other site 991791006001 Switch II region; other site 991791006002 G4 box; other site 991791006003 G5 box; other site 991791006004 This family represents the domain II of bacterial Initiation Factor 2 (IF2) and its eukaryotic mitochondrial homologue mtIF2. IF2, the largest initiation factor is an essential GTP binding protein. In E. coli three natural forms of IF2 exist in the cell; Region: IF2_mtIF2_II; cd03702 991791006005 Translation-initiation factor 2; Region: IF-2; pfam11987 991791006006 mtIF2_IVc: this family represents the C2 subdomain of domain IV of mitochondrial translation initiation factor 2 (mtIF2) which adopts a beta-barrel fold displaying a high degree of structural similarity with domain II of the translation elongation factor...; Region: mtIF2_IVc; cd03692 991791006007 ribosome-binding factor A; Validated; Region: rbfA; PRK00521 991791006008 Exopolyphosphatase-related proteins [General function prediction only]; Region: COG0618 991791006009 DHH family; Region: DHH; pfam01368 991791006010 DHHA1 domain; Region: DHHA1; pfam02272 991791006011 tRNA pseudouridine synthase B; Provisional; Region: truB; PRK00130 991791006012 Pseudouridine synthase, Escherichia coli TruB like; Region: PseudoU_synth_EcTruB; cd02573 991791006013 RNA binding site [nucleotide binding]; other site 991791006014 active site 991791006015 bifunctional riboflavin kinase/FMN adenylyltransferase; Reviewed; Region: PRK05627 991791006016 FAD synthetase, N-terminal domain of the bifunctional enzyme; Region: FAD_synthetase_N; cd02064 991791006017 active site 991791006018 Riboflavin kinase; Region: Flavokinase; smart00904 991791006019 Ribosomal protein S15 (prokaryotic)_S13 (eukaryotic) binds the central domain of 16S rRNA and is required for assembly of the small ribosomal subunit and for intersubunit association, thus representing a key element in the assembly of the whole ribosome; Region: Ribosomal_S15p_S13e; cd00353 991791006020 16S/18S rRNA binding site [nucleotide binding]; other site 991791006021 S13e-L30e interaction site [polypeptide binding]; other site 991791006022 25S rRNA binding site [nucleotide binding]; other site 991791006023 polynucleotide phosphorylase/polyadenylase; Provisional; Region: PRK11824 991791006024 Polyribonucleotide nucleotidyltransferase, repeat 1; Region: RNase_PH_PNPase_1; cd11363 991791006025 RNase E interface [polypeptide binding]; other site 991791006026 trimer interface [polypeptide binding]; other site 991791006027 Polyribonucleotide nucleotidyltransferase, RNA binding domain; Region: PNPase; pfam03726 991791006028 Polyribonucleotide nucleotidyltransferase, repeat 2; Region: RNase_PH_PNPase_2; cd11364 991791006029 RNase E interface [polypeptide binding]; other site 991791006030 trimer interface [polypeptide binding]; other site 991791006031 active site 991791006032 Polynucleotide phosphorylase (PNPase) K homology RNA-binding domain (KH). PNPase is a polyribonucleotide nucleotidyl transferase that degrades mRNA in prokaryotes and plant chloroplasts. The C-terminal region of PNPase contains domains homologous to...; Region: PNPase_KH; cd02393 991791006033 putative nucleic acid binding region [nucleotide binding]; other site 991791006034 G-X-X-G motif; other site 991791006035 S1_PNPase: Polynucleotide phosphorylase (PNPase), ), S1-like RNA-binding domain. PNPase is a polyribonucleotide nucleotidyl transferase that degrades mRNA. It is a trimeric multidomain protein. The C-terminus contains the S1 domain which binds ssRNA; Region: S1_PNPase; cd04472 991791006036 RNA binding site [nucleotide binding]; other site 991791006037 domain interface; other site 991791006038 sporulation protein, YlmC/YmxH family; Region: spore_YlmC_YmxH; TIGR02888 991791006039 aspartate kinase I; Reviewed; Region: PRK08210 991791006040 Amino Acid Kinases (AAK) superfamily, catalytic domain; present in such enzymes like N-acetylglutamate kinase (NAGK), carbamate kinase (CK), aspartokinase (AK), glutamate-5-kinase (G5K) and UMP kinase (UMPK). The AAK superfamily includes kinases that...; Region: AAK; cl00452 991791006041 nucleotide binding site [chemical binding]; other site 991791006042 substrate binding site [chemical binding]; other site 991791006043 ACT domains of the diaminopimelate-sensitive aspartokinase (AK) isoenzyme AKI; Region: ACT_AKi-DapG-BS_1; cd04914 991791006044 ACT domains of the diaminopimelate-sensitive aspartokinase (AK) isoenzyme AKI; Region: ACT_AKi-DapG-BS_2; cd04937 991791006045 Caseinolytic protease (ClpP) is an ATP-dependent protease; Region: Clp_protease_like; cl15763 991791006046 signal peptide peptidase SppA, 36K type; Region: SppA_dom; TIGR00706 991791006047 active site 991791006048 Domain of unknown function (DUF4117); Region: DUF4117; pfam13491 991791006049 DNA segregation ATPase FtsK/SpoIIIE and related proteins [Cell division and chromosome partitioning]; Region: FtsK; COG1674 991791006050 FtsK/SpoIIIE family; Region: FtsK_SpoIIIE; pfam01580 991791006051 Ftsk gamma domain; Region: Ftsk_gamma; pfam09397 991791006052 2-methylthioadenine synthetase [Translation, ribosomal structure and biogenesis]; Region: MiaB; COG0621 991791006053 Uncharacterized protein family UPF0004; Region: UPF0004; pfam00919 991791006054 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 991791006055 FeS/SAM binding site; other site 991791006056 CDP-alcohol phosphatidyltransferase; Region: CDP-OH_P_transf; cl00453 991791006057 recombinase A; Provisional; Region: recA; PRK09354 991791006058 RecA is a bacterial enzyme which has roles in homologous recombination, DNA repair, and the induction of the SOS response. RecA couples ATP hydrolysis to DNA strand exchange; Region: recA; cd00983 991791006059 hexamer interface [polypeptide binding]; other site 991791006060 Walker A motif; other site 991791006061 ATP binding site [chemical binding]; other site 991791006062 Walker B motif; other site 991791006063 Domain of unknown function (DUF3552); Region: DUF3552; pfam12072 991791006064 Predicted HD superfamily hydrolase [General function prediction only]; Region: COG1418 991791006065 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 991791006066 Zn2+ binding site [ion binding]; other site 991791006067 Mg2+ binding site [ion binding]; other site 991791006068 Stage V sporulation protein S (SpoVS); Region: SpoVS; pfam04232 991791006069 phosphoribose diphosphate:decaprenyl-phosphate phosphoribosyltransferase; Provisional; Region: PRK12324 991791006070 aspartate aminotransferase; Provisional; Region: PRK05764 991791006071 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 991791006072 pyridoxal 5'-phosphate binding site [chemical binding]; other site 991791006073 homodimer interface [polypeptide binding]; other site 991791006074 catalytic residue [active] 991791006075 Histidine-containing phosphocarrier protein (HPr)-like proteins. HPr is a central component of the bacterial phosphoenolpyruvate sugar phosphotransferase system (PTS). The PTS catalyses the phosphorylation of sugar substrates during their translocation...; Region: PTS-HPr_like; cd00367 991791006076 regulatory protein interface [polypeptide binding]; other site 991791006077 active site 991791006078 regulatory phosphorylation site [posttranslational modification]; other site 991791006079 Adenylosuccinate lyase [Nucleotide transport and metabolism]; Region: PurB; COG0015 991791006080 Adenylsuccinate lyase (ASL)_subgroup 2; Region: Adenylsuccinate_lyase_2; cd03302 991791006081 tetramer interface [polypeptide binding]; other site 991791006082 active site 991791006083 Putative peptidoglycan binding domain; Region: PG_binding_1; pfam01471 991791006084 Uncharacterized protein conserved in bacteria [Function unknown]; Region: ErfK; COG1376 991791006085 L,D-transpeptidase catalytic domain; Region: YkuD; pfam03734 991791006086 Uncharacterized conserved protein [Function unknown]; Region: COG2127 991791006087 ATP-dependent Clp protease ATP-binding subunit clpA; Region: ClpA; TIGR02639 991791006088 Clp amino terminal domain; Region: Clp_N; pfam02861 991791006089 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 991791006090 Walker A motif; other site 991791006091 ATP binding site [chemical binding]; other site 991791006092 Walker B motif; other site 991791006093 arginine finger; other site 991791006094 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 991791006095 Walker A motif; other site 991791006096 ATP binding site [chemical binding]; other site 991791006097 Walker B motif; other site 991791006098 C-terminal, D2-small domain, of ClpB protein; Region: ClpB_D2-small; smart01086 991791006099 Homoserine O-succinyltransferase; Region: HTS; pfam04204 991791006100 Type 1 glutamine amidotransferase (GATase1)-like domain found in homoserine trans-succinylase (HTS); Region: GATase1_HTS; cd03131 991791006101 proposed active site lysine [active] 991791006102 conserved cys residue [active] 991791006103 Type 1 glutamine amidotransferase (GATase1)-like domain; Region: GAT_1; cl00020 991791006104 Predicted Zn-dependent proteases and their inactivated homologs [General function prediction only]; Region: TldD; COG0312 991791006105 Predicted Zn-dependent proteases and their inactivated homologs [General function prediction only]; Region: TldD; COG0312 991791006106 site-specific tyrosine recombinase XerC; Reviewed; Region: xerC; PRK00236 991791006107 DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213 991791006108 active site 991791006109 DNA binding site [nucleotide binding] 991791006110 Int/Topo IB signature motif; other site 991791006111 LexA repressor; Validated; Region: PRK00215 991791006112 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 991791006113 putative DNA binding site [nucleotide binding]; other site 991791006114 putative Zn2+ binding site [ion binding]; other site 991791006115 Peptidase S24 LexA-like proteins are involved in the SOS response leading to the repair of single-stranded DNA within the bacterial cell. This family includes: the lambda repressor CI/C2 family and related bacterial prophage repressor proteins; LexA (EC...; Region: S24_LexA-like; cd06529 991791006116 Catalytic site [active] 991791006117 Cystathionine beta-lyase family protein involved in aluminum resistance [Inorganic ion transport and metabolism]; Region: COG4100 991791006118 Aluminium resistance protein; Region: Alum_res; pfam06838 991791006119 bacterial Hfq-like; Region: Hfq; cd01716 991791006120 hexamer interface [polypeptide binding]; other site 991791006121 Sm1 motif; other site 991791006122 RNA binding site [nucleotide binding]; other site 991791006123 Sm2 motif; other site 991791006124 tRNA delta(2)-isopentenylpyrophosphate transferase [Translation, ribosomal structure and biogenesis]; Region: MiaA; COG0324 991791006125 tRNA delta(2)-isopentenylpyrophosphate transferase; Reviewed; Region: miaA; PRK00091 991791006126 DNA mismatch repair protein; Reviewed; Region: mutL; PRK00095 991791006127 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 991791006128 ATP binding site [chemical binding]; other site 991791006129 Mg2+ binding site [ion binding]; other site 991791006130 G-X-G motif; other site 991791006131 MutL_Trans: transducer domain, having a ribosomal S5 domain 2-like fold, conserved in the C-terminal domain of DNA mismatch repair (MutL/MLH1/PMS2) family. This transducer domain is homologous to the second domain of the DNA gyrase B subunit, which is...; Region: MutL_Trans; cd00782 991791006132 ATP binding site [chemical binding]; other site 991791006133 MutL C terminal dimerisation domain; Region: MutL_C; pfam08676 991791006134 DNA mismatch repair protein MutS; Provisional; Region: PRK05399 991791006135 MutS domain I; Region: MutS_I; pfam01624 991791006136 MutS domain II; Region: MutS_II; pfam05188 991791006137 MutS domain III; Region: MutS_III; pfam05192 991791006138 ATP-binding cassette domain of MutS1 homolog; Region: ABC_MutS1; cd03284 991791006139 Walker A/P-loop; other site 991791006140 ATP binding site [chemical binding]; other site 991791006141 Q-loop/lid; other site 991791006142 ABC transporter signature motif; other site 991791006143 Walker B; other site 991791006144 D-loop; other site 991791006145 H-loop/switch region; other site 991791006146 (dimethylallyl)adenosine tRNA methylthiotransferase; Provisional; Region: PRK14328 991791006147 Uncharacterized protein family UPF0004; Region: UPF0004; pfam00919 991791006148 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 991791006149 FeS/SAM binding site; other site 991791006150 TRAM domain; Region: TRAM; pfam01938 991791006151 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 991791006152 Coenzyme A binding pocket [chemical binding]; other site 991791006153 spore coat protein YsxE; Region: spore_ysxE; TIGR02904 991791006154 spore coat protein, CotS family; Region: spore_CotS; TIGR02906 991791006155 Aminoglycoside 3'-phosphotransferase (APH) and Choline Kinase (ChoK) family. The APH/ChoK family is part of a larger superfamily that includes the catalytic domains of other kinases, such as the typical serine/threonine/tyrosine protein kinases (PKs)...; Region: APH_ChoK_like; cl17270 991791006156 active site 991791006157 ATP binding site [chemical binding]; other site 991791006158 substrate binding site [chemical binding]; other site 991791006159 Phage-related holin (Lysis protein) [General function prediction only]; Region: COG4824 991791006160 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 991791006161 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 991791006162 non-specific DNA binding site [nucleotide binding]; other site 991791006163 salt bridge; other site 991791006164 sequence-specific DNA binding site [nucleotide binding]; other site 991791006165 Flagellar motor protein [Cell motility and secretion]; Region: MotB; COG1360 991791006166 Membrane MotB of proton-channel complex MotA/MotB; Region: MotB_plug; pfam13677 991791006167 Peptidoglycan binding domains similar to the C-terminal domain of outer-membrane protein OmpA; Region: OmpA_C-like; cd07185 991791006168 ligand binding site [chemical binding]; other site 991791006169 flagellar motor protein MotA; Validated; Region: PRK08124 991791006170 MotA/TolQ/ExbB proton channel family; Region: MotA_ExbB; cl00568 991791006171 LytB protein; Region: LYTB; cl00507 991791006172 4-hydroxy-3-methylbut-2-enyl diphosphate reductase/S1 RNA-binding domain protein; Reviewed; Region: PRK00087 991791006173 S1_RPS1_repeat_ec1_hs1: Ribosomal protein S1 (RPS1) domain. RPS1 is a component of the small ribosomal subunit thought to be involved in the recognition and binding of mRNA's during translation initiation. The bacterial RPS1 domain architecture...; Region: S1_RPS1_repeat_ec1_hs1; cd05687 991791006174 RNA binding site [nucleotide binding]; other site 991791006175 S1_RPS1_repeat_ec2_hs2: Ribosomal protein S1 (RPS1) domain. RPS1 is a component of the small ribosomal subunit thought to be involved in the recognition and binding of mRNA's during translation initiation. The bacterial RPS1 domain architecture...; Region: S1_RPS1_repeat_ec2_hs2; cd04465 991791006176 RNA binding site [nucleotide binding]; other site 991791006177 S1_RPS1_repeat_ec3: Ribosomal protein S1 (RPS1) domain. RPS1 is a component of the small ribosomal subunit thought to be involved in the recognition and binding of mRNA's during translation initiation. The bacterial RPS1 domain architecture consists...; Region: S1_RPS1_repeat_ec3; cd05688 991791006178 RNA binding site [nucleotide binding]; other site 991791006179 S1_RPS1_repeat_hs4: Ribosomal protein S1 (RPS1) domain. RPS1 is a component of the small ribosomal subunit thought to be involved in the recognition and binding of mRNA's during translation initiation. The bacterial RPS1 domain architecture consists...; Region: S1_RPS1_repeat_hs4; cd05692 991791006180 RNA binding site [nucleotide binding]; other site 991791006181 cytidylate kinase; Provisional; Region: cmk; PRK00023 991791006182 Cytidine monophosphate kinase (CMPK) catalyzes the reversible phosphorylation of cytidine monophosphate (CMP) to produce cytidine diphosphate (CDP), using ATP as the preferred phosphoryl donor; Region: CMPK; cd02020 991791006183 CMP-binding site; other site 991791006184 The sites determining sugar specificity; other site 991791006185 Predicted flavoproteins [General function prediction only]; Region: COG2081 991791006186 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 991791006187 Transcriptional regulators [Transcription]; Region: RpiR; COG1737 991791006188 Helix-turn-helix domain, rpiR family; Region: HTH_6; pfam01418 991791006189 RpiR-like protein. RpiR contains a SIS (Sugar ISomerase) domain, which is found in many phosphosugar isomerases and phosphosugar binding proteins. In E. coli, rpiR negatively regulates the expression of rpiB gene. Both rpiB and rpiA are ribose phosphate...; Region: SIS_RpiR; cd05013 991791006190 putative active site [active] 991791006191 16S rRNA uridine-516 pseudouridylate synthase and related pseudouridylate synthases [Translation, ribosomal structure and biogenesis]; Region: RsuA; COG1187 991791006192 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 991791006193 RNA binding surface [nucleotide binding]; other site 991791006194 Pseudouridine synthases, RsuA subfamily; Region: PseudoU_synth_RsuA_like; cd02870 991791006195 active site 991791006196 Mg2+ and Co2+ transporters [Inorganic ion transport and metabolism]; Region: CorA; COG0598 991791006197 Thermotoga maritima CorA_like subfamily; Region: TmCorA-like_1; cd12828 991791006198 oligomer interface [polypeptide binding]; other site 991791006199 metal binding site [ion binding]; metal-binding site 991791006200 metal binding site [ion binding]; metal-binding site 991791006201 Cl binding site [ion binding]; other site 991791006202 aspartate ring; other site 991791006203 basic sphincter; other site 991791006204 putative hydrophobic gate; other site 991791006205 periplasmic entrance; other site 991791006206 ADP-ribose pyrophosphatase (ADPRase) catalyzes the hydrolysis of ADP-ribose and a variety of additional ADP-sugar conjugates to AMP and ribose-5-phosphate. Like other members of the Nudix hydrolase superfamily, it requires a divalent cation, such as Mg2+; Region: ADPRase_NUDT5; cd03424 991791006207 dimer interface [polypeptide binding]; other site 991791006208 ADP-ribose binding site [chemical binding]; other site 991791006209 active site 991791006210 nudix motif; other site 991791006211 metal binding site [ion binding]; metal-binding site 991791006212 Predicted double-stranded RNA/RNA-DNA hybrid binding protein [General function prediction only]; Region: COG3341 991791006213 Bacterial RNase HI containing a hybrid binding domain (HBD) at the N-terminus; Region: RNase_HI_bacteria_HBD; cd09277 991791006214 RNA/DNA hybrid binding site [nucleotide binding]; other site 991791006215 active site 991791006216 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3864 991791006217 Von Willebrand factor type A (vWA) domain was originally found in the blood coagulation protein von Willebrand factor (vWF). Typically, the vWA domain is made up of approximately 200 amino acid residues folded into a classic a/b para-rossmann type of...; Region: vWFA; cl00057 991791006218 metal ion-dependent adhesion site (MIDAS); other site 991791006219 MoxR-like ATPases [General function prediction only]; Region: COG0714 991791006220 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 991791006221 Walker A motif; other site 991791006222 ATP binding site [chemical binding]; other site 991791006223 Walker B motif; other site 991791006224 hypothetical protein; Provisional; Region: PRK05802 991791006225 FAD/NAD binding domain (electron transfer subunit) of dihydroorotate dehydrogenase-like proteins. Dihydroorotate dehydrogenases (DHODs) catalyze the only redox reaction in pyrimidine de novo biosynthesis. They catalyze the oxidation of (S)-dihydroorotate...; Region: DHOD_e_trans_like; cd06192 991791006226 FAD binding pocket [chemical binding]; other site 991791006227 FAD binding motif [chemical binding]; other site 991791006228 phosphate binding motif [ion binding]; other site 991791006229 beta-alpha-beta structure motif; other site 991791006230 NAD binding pocket [chemical binding]; other site 991791006231 Iron coordination center [ion binding]; other site 991791006232 Site-specific recombinases, DNA invertase Pin homologs [DNA replication, recombination, and repair]; Region: PinR; COG1961 991791006233 Serine Recombinase (SR) family, Resolvase and Invertase subfamily, catalytic domain; members contain a C-terminal DNA binding domain. Serine recombinases catalyze site-specific recombination of DNA molecules by a concerted, four-strand cleavage and...; Region: SR_ResInv; cd03768 991791006234 catalytic residues [active] 991791006235 catalytic nucleophile [active] 991791006236 Presynaptic Site I dimer interface [polypeptide binding]; other site 991791006237 Synaptic Antiparallel dimer interface [polypeptide binding]; other site 991791006238 Synaptic Flat tetramer interface [polypeptide binding]; other site 991791006239 Synaptic Site I dimer interface [polypeptide binding]; other site 991791006240 DNA binding site [nucleotide binding] 991791006241 Recombinase; Region: Recombinase; pfam07508 991791006242 Recombinase zinc beta ribbon domain; Region: Zn_ribbon_recom; pfam13408 991791006243 Glucose inhibited division protein A; Region: GIDA; pfam01134 991791006244 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 991791006245 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 991791006246 non-specific DNA binding site [nucleotide binding]; other site 991791006247 salt bridge; other site 991791006248 sequence-specific DNA binding site [nucleotide binding]; other site 991791006249 Domain of unknown function (DUF4352); Region: DUF4352; pfam11611 991791006250 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 991791006251 non-specific DNA binding site [nucleotide binding]; other site 991791006252 salt bridge; other site 991791006253 sequence-specific DNA binding site [nucleotide binding]; other site 991791006254 FtsK/SpoIIIE family; Region: FtsK_SpoIIIE; pfam01580 991791006255 ATPases associated with a variety of cellular activities; Region: AAA; smart00382 991791006256 Plasmid rolling circle replication initiator protein and truncated derivatives [DNA replication, recombination, and repair]; Region: COG5655 991791006257 Lyc muramidase is an autolytic lysozyme (autolysin) from Clostridium acetobutylicum encoded by the lyc gene. Lyc has a glycosyl hydrolase family 25 (GH25) catalytic domain. Endo-N-acetylmuramidases are lysozymes (also referred to as peptidoglycan...; Region: GH25_Lyc-like; cd06525 991791006258 Glycosyl hydrolases family 25; Region: Glyco_hydro_25; pfam01183 991791006259 active site 991791006260 Putative peptidoglycan-binding domain-containing protein [Cell envelope biogenesis, outer membrane]; Region: COG3409 991791006261 Putative peptidoglycan binding domain; Region: PG_binding_1; pfam01471 991791006262 Putative peptidoglycan binding domain; Region: PG_binding_1; pfam01471 991791006263 Haemolysin XhlA; Region: XhlA; pfam10779 991791006264 phage minor structural protein, N-terminal region; Region: put_anti_recept; TIGR01665 991791006265 Carbohydrate binding domain; Region: CBM_4_9; pfam02018 991791006266 Chaperone of endosialidase; Region: Peptidase_S74; pfam13884 991791006267 Protein of unknown function (DUF1617); Region: DUF1617; pfam07761 991791006268 TPR/MLP1/MLP2-like protein; Region: TPR_MLP1_2; pfam07926 991791006269 phage tail tape measure protein, TP901 family, core region; Region: tape_meas_TP901; TIGR01760 991791006270 Lytic Transglycosylase (LT) and Goose Egg White Lysozyme (GEWL) domain. Members include the soluble and insoluble membrane-bound LTs in bacteria, the LTs in bacteriophage lambda, as well as, the eukaryotic "goose-type" lysozymes (GEWL). LTs...; Region: LT_GEWL; cd00254 991791006271 N-acetyl-D-glucosamine binding site [chemical binding]; other site 991791006272 phage major tail protein, phi13 family; Region: maj_tail_phi13; TIGR01603 991791006273 Bacterial Ig-like domain; Region: Big_5; pfam13205 991791006274 phage protein, HK97 gp10 family; Region: phge_HK97_gp10; TIGR01725 991791006275 Bacteriophage head-tail adaptor [General function prediction only]; Region: COG5614 991791006276 Head-Tail Connector Protein gp6 of Bacteriophage HK97 and similar proteins; Region: gp6; cd08054 991791006277 oligomerization interface [polypeptide binding]; other site 991791006278 phage major capsid protein, HK97 family; Region: major_cap_HK97; TIGR01554 991791006279 Phage capsid family; Region: Phage_capsid; pfam05065 991791006280 Protease subunit of ATP-dependent Clp proteases [Posttranslational modification, protein turnover, chaperones / Intracellular trafficking and secretion]; Region: ClpP; COG0740 991791006281 Caseinolytic protease (ClpP) is an ATP-dependent, highly conserved serine protease; Region: S14_ClpP_1; cd07016 991791006282 oligomer interface [polypeptide binding]; other site 991791006283 active site residues [active] 991791006284 Phage-related protein [Function unknown]; Region: COG4695 991791006285 Phage portal protein; Region: Phage_portal; pfam04860 991791006286 Phage terminase-like protein, large subunit [General function prediction only]; Region: COG4626 991791006287 Phage terminase, small subunit [DNA replication, recombination, and repair]; Region: COG3747 991791006288 Restriction endonuclease [Defense mechanisms]; Region: McrA; COG1403 991791006289 HNH nucleases; HNH endonuclease signature which is found in viral, prokaryotic, and eukaryotic proteins. The alignment includes members of the large group of homing endonucleases, yeast intron 1 protein, MutS, as well as bacterial colicins, pyocins, and...; Region: HNHc; cd00085 991791006290 active site 991791006291 Mu-like prophage protein Com [General function prediction only]; Region: Com; COG4416 991791006292 Ribonuclease D [Translation, ribosomal structure and biogenesis]; Region: Rnd; COG0349 991791006293 DEDDy 3'-5' exonuclease domain of Ribonuclease D and similar proteins; Region: RNaseD_exo; cd06142 991791006294 catalytic site [active] 991791006295 putative active site [active] 991791006296 putative substrate binding site [chemical binding]; other site 991791006297 Helix-turn-helix domain; Region: HTH_17; pfam12728 991791006298 DNA-directed RNA polymerase, subunit RPC10 (contains C4-type Zn-finger) [Transcription]; Region: RPC10; COG1996 991791006299 Single-stranded DNA-binding protein [DNA replication, recombination, and repair]; Region: Ssb; COG0629 991791006300 SSB_OBF: A subfamily of OB folds similar to the OB fold of ssDNA-binding protein (SSB). SSBs bind with high affinity to ssDNA. They bind to and protect ssDNA intermediates during DNA metabolic pathways. All bacterial and eukaryotic SSBs studied to date...; Region: SSB_OBF; cd04496 991791006301 dimer interface [polypeptide binding]; other site 991791006302 ssDNA binding site [nucleotide binding]; other site 991791006303 tetramer (dimer of dimers) interface [polypeptide binding]; other site 991791006304 Restriction alleviation protein Lar; Region: Lar_restr_allev; cl08047 991791006305 Nucleoside Triphosphate Pyrophosphohydrolase (EC 3.6.1.8) MazG-like domain found in a group of uncharacterized proteins from bacteria and archaea; Region: NTP-PPase_u5; cd11542 991791006306 metal binding site [ion binding]; metal-binding site 991791006307 hypothetical protein; Validated; Region: PRK08116 991791006308 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 991791006309 Walker A motif; other site 991791006310 ATP binding site [chemical binding]; other site 991791006311 Walker B motif; other site 991791006312 N-terminal phage replisome organiser (Phage_rep_org_N); Region: Phage_rep_org_N; pfam09681 991791006313 Coronavirus S2 glycoprotein; Region: Corona_S2; pfam01601 991791006314 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4712 991791006315 Predicted HD-superfamily hydrolase [General function prediction only]; Region: COG3481 991791006316 CRISPR/Cas system-associated protein Cas3'' Region: Cas3''_I; cl17503 991791006317 SpoVT / AbrB like domain; Region: SpoVT_AbrB; smart00966 991791006318 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4306 991791006319 Phage anti-repressor protein [Transcription]; Region: COG3561 991791006320 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 991791006321 non-specific DNA binding site [nucleotide binding]; other site 991791006322 salt bridge; other site 991791006323 sequence-specific DNA binding site [nucleotide binding]; other site 991791006324 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 991791006325 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 991791006326 non-specific DNA binding site [nucleotide binding]; other site 991791006327 salt bridge; other site 991791006328 sequence-specific DNA binding site [nucleotide binding]; other site 991791006329 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 991791006330 non-specific DNA binding site [nucleotide binding]; other site 991791006331 salt bridge; other site 991791006332 sequence-specific DNA binding site [nucleotide binding]; other site 991791006333 Predicted transcriptional regulator [Transcription]; Region: COG3655 991791006334 Site-specific recombinases, DNA invertase Pin homologs [DNA replication, recombination, and repair]; Region: PinR; COG1961 991791006335 Serine Recombinase (SR) family, Resolvase and Invertase subfamily, catalytic domain; members contain a C-terminal DNA binding domain. Serine recombinases catalyze site-specific recombination of DNA molecules by a concerted, four-strand cleavage and...; Region: SR_ResInv; cd03768 991791006336 catalytic residues [active] 991791006337 catalytic nucleophile [active] 991791006338 Presynaptic Site I dimer interface [polypeptide binding]; other site 991791006339 Synaptic Antiparallel dimer interface [polypeptide binding]; other site 991791006340 Synaptic Flat tetramer interface [polypeptide binding]; other site 991791006341 Synaptic Site I dimer interface [polypeptide binding]; other site 991791006342 DNA binding site [nucleotide binding] 991791006343 Recombinase; Region: Recombinase; pfam07508 991791006344 Recombinase zinc beta ribbon domain; Region: Zn_ribbon_recom; pfam13408 991791006345 Glucose inhibited division protein A; Region: GIDA; pfam01134 991791006346 Membrane protein of unknown function; Region: DUF360; pfam04020 991791006347 Uncharacterized conserved small protein [Function unknown]; Region: COG5515 991791006348 Site-specific recombinases, DNA invertase Pin homologs [DNA replication, recombination, and repair]; Region: PinR; COG1961 991791006349 Serine Recombinase family, catalytic domain; a DNA binding domain may be present either N- or C-terminal to the catalytic domain. These enzymes perform site-specific recombination of DNA molecules by a concerted, four-strand cleavage and rejoining...; Region: Ser_Recombinase; cd00338 991791006350 catalytic residues [active] 991791006351 catalytic nucleophile [active] 991791006352 Recombinase; Region: Recombinase; pfam07508 991791006353 Recombinase zinc beta ribbon domain; Region: Zn_ribbon_recom; pfam13408 991791006354 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 991791006355 Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248 991791006356 active site 991791006357 catalytic tetrad [active] 991791006358 Protein of unknown function (DUF1256); Region: DUF1256; pfam06866 991791006359 Protein of unknown function (DUF1256); Region: DUF1256; pfam06866 991791006360 Saccharomyces cerevisiae DCR2 phosphatase and related proteins, metallophosphatase domain; Region: MPP_Dcr2; cd07383 991791006361 Calcineurin-like phosphoesterase; Region: Metallophos; pfam00149 991791006362 putative active site [active] 991791006363 putative metal binding site [ion binding]; other site 991791006364 Saccharomyces cerevisiae DCR2 phosphatase and related proteins, metallophosphatase domain; Region: MPP_Dcr2; cd07383 991791006365 Predicted hydrolase of the alpha/beta superfamily [General function prediction only]; Region: COG2819 991791006366 5'-nucleotidase/2',3'-cyclic phosphodiesterase and related esterases [Nucleotide transport and metabolism]; Region: UshA; COG0737 991791006367 Escherichia coli CpdB and related proteins, N-terminal metallophosphatase domain; Region: MPP_CpdB_N; cd07410 991791006368 active site 991791006369 metal binding site [ion binding]; metal-binding site 991791006370 5'-nucleotidase, C-terminal domain; Region: 5_nucleotid_C; pfam02872 991791006371 Ribosomal protein S1 [Translation, ribosomal structure and biogenesis]; Region: RpsA; COG0539 991791006372 Ribosomal protein S1-like RNA-binding domain; Region: S1; smart00316 991791006373 transcription elongation factor GreA; Region: greA; TIGR01462 991791006374 Transcription elongation factor, N-terminal; Region: GreA_GreB_N; pfam03449 991791006375 Transcription elongation factor, GreA/GreB, C-term; Region: GreA_GreB; pfam01272 991791006376 pectinesterase/pectinesterase inhibitor; Region: PLN02301 991791006377 Right handed beta helix region; Region: Beta_helix; pfam13229 991791006378 Type IV secretory pathway, VirD4 components [Intracellular trafficking and secretion]; Region: VirD4; COG3505 991791006379 The TraG/TraD/VirD4 family are bacterial conjugation proteins involved in type IV secretion. These proteins aid the transfer of DNA from the plasmid into the host bacterial chromosome. They contain an ATP binding domain. VirD4 is involved in DNA transfer...; Region: TraG_VirD4; cd01126 991791006380 Walker A motif; other site 991791006381 ATP binding site [chemical binding]; other site 991791006382 Walker B motif; other site 991791006383 Type IV leader peptidase family; Region: Peptidase_A24; pfam01478 991791006384 SAF domains of the flagella basal body P-ring formation protein FlgA and the flp pilus assembly CpaB; Region: SAF_CpaB_FlgA_like; cd11614 991791006385 Flp pilus assembly protein TadC [Cell motility and secretion / Intracellular trafficking and secretion]; Region: TadC; COG2064 991791006386 Flp pilus assembly protein, ATPase CpaF [Intracellular trafficking and secretion]; Region: CpaF; COG4962 991791006387 RecA-like NTPases. This family includes the NTP binding domain of F1 and V1 H+ATPases, DnaB and related helicases as well as bacterial RecA and related eukaryotic and archaeal recombinases. This group also includes bacterial conjugation proteins and...; Region: RecA-like_NTPases; cl17233 991791006388 Walker A motif; other site 991791006389 ATP binding site [chemical binding]; other site 991791006390 Walker B motif; other site 991791006391 AAA domain; Region: AAA_31; pfam13614 991791006392 EamA-like transporter family; Region: EamA; pfam00892 991791006393 ABC-type Fe3+-hydroxamate transport system, periplasmic component [Inorganic ion transport and metabolism]; Region: FepB; COG0614 991791006394 Periplasmic binding protein TroA_e. These proteins are predicted to function as initial receptors in the ABC metal ion uptake in eubacteria and archaea. They belong to the TroA superfamily of helical backbone metal receptor proteins that share a...; Region: TroA_e; cd01142 991791006395 putative ligand binding residues [chemical binding]; other site 991791006396 ABC-type cobalamin/Fe3+-siderophores transport systems, ATPase components [Inorganic ion transport and metabolism / Coenzyme metabolism]; Region: FepC; COG1120 991791006397 ATP-binding component of iron-siderophores, vitamin B12 and hemin transporters and related proteins; Region: ABC_Iron-Siderophores_B12_Hemin; cd03214 991791006398 Walker A/P-loop; other site 991791006399 ATP binding site [chemical binding]; other site 991791006400 Q-loop/lid; other site 991791006401 ABC transporter signature motif; other site 991791006402 Walker B; other site 991791006403 D-loop; other site 991791006404 H-loop/switch region; other site 991791006405 iron-hydroxamate transporter permease subunit; Provisional; Region: PRK10577 991791006406 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550 991791006407 ABC-ATPase subunit interface; other site 991791006408 dimer interface [polypeptide binding]; other site 991791006409 putative PBP binding regions; other site 991791006410 MOSC domain; Region: MOSC; pfam03473 991791006411 MoaC family, prokaryotic and eukaryotic. Members of this family are involved in molybdenum cofactor (Moco) biosynthesis, an essential cofactor of a diverse group of redox enzymes. MoaC, a small hexameric protein, converts, together with MoaA, a guanosine...; Region: MoaC_PE; cd01420 991791006412 trimer interface [polypeptide binding]; other site 991791006413 dimer interface [polypeptide binding]; other site 991791006414 putative active site [active] 991791006415 molybdenum cofactor biosynthesis protein A, bacterial; Region: moaA; TIGR02666 991791006416 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 991791006417 FeS/SAM binding site; other site 991791006418 Molybdenum Cofactor Synthesis C; Region: Mob_synth_C; pfam06463 991791006419 MogA_MoaB family. Members of this family are involved in biosynthesis of the molybdenum cofactor (MoCF) an essential cofactor of a diverse group of redox enzymes. MoCF biosynthesis is an evolutionarily conserved pathway present in eubacteria, archaea; Region: MogA_MoaB; cd00886 991791006420 MPT binding site; other site 991791006421 trimer interface [polypeptide binding]; other site 991791006422 Glycosyl transferases, related to UDP-glucuronosyltransferase [Carbohydrate transport and metabolism / Signal transduction mechanisms]; Region: COG1819 991791006423 Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013 991791006424 ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136 991791006425 ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255 991791006426 Walker A/P-loop; other site 991791006427 ATP binding site [chemical binding]; other site 991791006428 Q-loop/lid; other site 991791006429 ABC transporter signature motif; other site 991791006430 Walker B; other site 991791006431 D-loop; other site 991791006432 H-loop/switch region; other site 991791006433 indolepyruvate oxidoreductase subunit beta; Reviewed; Region: PRK06853 991791006434 indolepyruvate ferredoxin oxidoreductase, alpha subunit; Region: IOR_alpha; TIGR03336 991791006435 Pyrimidine (PYR) binding domain of pyruvate ferredoxin oxidoreductase (PFOR), indolepyruvate ferredoxin oxidoreductase alpha subunit (IOR-alpha), and related proteins; Region: TPP_PYR_PFOR_IOR-alpha_like; cd07034 991791006436 dimer interface [polypeptide binding]; other site 991791006437 PYR/PP interface [polypeptide binding]; other site 991791006438 TPP binding site [chemical binding]; other site 991791006439 substrate binding site [chemical binding]; other site 991791006440 Thiamine pyrophosphate (TPP) family, IOR-alpha subfamily, TPP-binding module; composed of proteins similar to indolepyruvate ferredoxin oxidoreductase (IOR) alpha subunit. IOR catalyzes the oxidative decarboxylation of arylpyruvates, such as...; Region: TPP_IOR_alpha; cd02008 991791006441 TPP-binding site; other site 991791006442 Flavodoxin-like fold; Region: Flavodoxin_2; pfam02525 991791006443 NADPH-dependent FMN reductase; Region: FMN_red; pfam03358 991791006444 Multimeric flavodoxin WrbA [General function prediction only]; Region: WrbA; COG0655 991791006445 MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704 991791006446 FtsX-like permease family; Region: FtsX; pfam02687 991791006447 MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704 991791006448 FtsX-like permease family; Region: FtsX; pfam02687 991791006449 Uncharacterized protein containing a NRPS condensation (elongation) domain [General function prediction only]; Region: COG4908 991791006450 Uncharacterized protein containing a NRPS condensation (elongation) domain [General function prediction only]; Region: COG4908 991791006451 Phosphopantetheinyl transferase [Coenzyme metabolism]; Region: Sfp; COG2091 991791006452 4'-phosphopantetheinyl transferase superfamily; Region: ACPS; pfam01648 991791006453 Glycosyl transferases, related to UDP-glucuronosyltransferase [Carbohydrate transport and metabolism / Signal transduction mechanisms]; Region: COG1819 991791006454 Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013 991791006455 beta-ketoacyl-acyl-carrier-protein synthase II; Region: fabF; TIGR03150 991791006456 Beta-ketoacyl-acyl carrier protein (ACP) synthase (KAS), type I and II. KASs are responsible for the elongation steps in fatty acid biosynthesis. KASIII catalyses the initial condensation and KAS I and II catalyze further elongation steps by Claisen...; Region: KAS_I_II; cd00834 991791006457 dimer interface [polypeptide binding]; other site 991791006458 active site 991791006459 3-hydroxyacyl-CoA dehydrogenase [Lipid metabolism]; Region: FadB; COG1250 991791006460 3-hydroxyacyl-CoA dehydrogenase, NAD binding domain; Region: 3HCDH_N; pfam02737 991791006461 3-hydroxyacyl-CoA dehydrogenase, C-terminal domain; Region: 3HCDH; pfam00725 991791006462 Fe-S oxidoreductase [Energy production and conversion]; Region: COG1032 991791006463 B12 binding domain_like associated with radical SAM domain. This domain shows similarity with B12 (adenosylcobamide) binding domains found in several enzymes, such as glutamate mutase, methionine synthase and methylmalonyl-CoA mutase, but it lacks the...; Region: radical_SAM_B12_BD; cd02068 991791006464 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 991791006465 FeS/SAM binding site; other site 991791006466 3-oxoacyl-[acyl-carrier-protein]; Region: FabH; COG0332 991791006467 "initiating" condensing enzymes are a subclass of decarboxylating condensing enzymes, including beta-ketoacyl [ACP] synthase, type III and polyketide synthases, type III, which include chalcone synthase and related enzymes. They are...; Region: init_cond_enzymes; cd00827 991791006468 dimer interface [polypeptide binding]; other site 991791006469 active site 991791006470 Enoyl-CoA hydratase/carnithine racemase [Lipid metabolism]; Region: CaiD; COG1024 991791006471 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 991791006472 substrate binding site [chemical binding]; other site 991791006473 oxyanion hole (OAH) forming residues; other site 991791006474 trimer interface [polypeptide binding]; other site 991791006475 4-hydroxybenzoyl-CoA thioesterase (4HBT). Catalyzes the final step in the 4-chlorobenzoate degradation pathway in which 4-chlorobenzoate is converted to 4-hydroxybenzoate in certain soil-dwelling bacteria. 4HBT forms a homotetramer with four active sites; Region: 4HBT; cd00586 991791006476 active site 991791006477 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 991791006478 Enoyl-CoA hydratase/isomerase family; Region: ECH; pfam00378 991791006479 substrate binding site [chemical binding]; other site 991791006480 oxyanion hole (OAH) forming residues; other site 991791006481 trimer interface [polypeptide binding]; other site 991791006482 Acyl carrier protein [Lipid metabolism / Secondary metabolites biosynthesis, transport, and catabolism]; Region: AcpP; COG0236 991791006483 Aldehyde:ferredoxin oxidoreductase [Energy production and conversion]; Region: COG2414 991791006484 Aldehyde ferredoxin oxidoreductase, N-terminal domain; Region: AFOR_N; smart00790 991791006485 Aldehyde ferredoxin oxidoreductase, domains 2 & 3; Region: AFOR_C; pfam01314 991791006486 (acyl-carrier-protein) S-malonyltransferase [Lipid metabolism]; Region: FabD; COG0331 991791006487 malonyl CoA-acyl carrier protein transacylase; Region: fabD; TIGR00128 991791006488 putative molybdopterin biosynthesis protein MoeA/LysR substrate binding-domain-containing protein; Provisional; Region: PRK14498 991791006489 MoeA family. Members of this family are involved in biosynthesis of the molybdenum cofactor (MoCF), an essential cofactor of a diverse group of redox enzymes. MoCF biosynthesis is an evolutionarily conserved pathway present in eubacteria, archaea and...; Region: MoeA; cd00887 991791006490 dimer interface [polypeptide binding]; other site 991791006491 putative functional site; other site 991791006492 putative MPT binding site; other site 991791006493 Periplasmic molybdate-binding protein/domain [Inorganic ion transport and metabolism]; Region: COG1910 991791006494 Molybdopterin biosynthesis enzyme [Coenzyme metabolism]; Region: MoeA; COG0303 991791006495 MoeA family. Members of this family are involved in biosynthesis of the molybdenum cofactor (MoCF), an essential cofactor of a diverse group of redox enzymes. MoCF biosynthesis is an evolutionarily conserved pathway present in eubacteria, archaea and...; Region: MoeA; cd00887 991791006496 dimer interface [polypeptide binding]; other site 991791006497 putative functional site; other site 991791006498 putative MPT binding site; other site 991791006499 MogA_MoaB family. Members of this family are involved in biosynthesis of the molybdenum cofactor (MoCF) an essential cofactor of a diverse group of redox enzymes. MoCF biosynthesis is an evolutionarily conserved pathway present in eubacteria, archaea; Region: MogA_MoaB; cd00886 991791006500 MPT binding site; other site 991791006501 trimer interface [polypeptide binding]; other site 991791006502 Phosphatidylglycerophosphate synthase [Lipid metabolism]; Region: PgsA; COG0558 991791006503 START/RHO_alpha_C/PITP/Bet_v1/CoxG/CalC (SRPBCC) ligand-binding domain superfamily; Region: SRPBCC; cl14643 991791006504 hydrophobic ligand binding site; other site 991791006505 Flavodoxin-like fold; Region: Flavodoxin_2; cl00438 991791006506 Protein of unknown function (DUF4237); Region: DUF4237; pfam14021 991791006507 Myosin and Kinesin motor domain. These ATPases belong to the P-loop NTPase family and provide the driving force in myosin and kinesin mediated processes; Region: Motor_domain; cl00286 991791006508 Preprotein translocase subunit; Region: YajC; cl00806 991791006509 ABC-type multidrug transport system, ATPase component [Defense mechanisms]; Region: CcmA; COG1131 991791006510 ATP-binding cassette domain of the bacitracin-resistance transporter; Region: ABC_BcrA_bacitracin_resist; cd03268 991791006511 Walker A/P-loop; other site 991791006512 ATP binding site [chemical binding]; other site 991791006513 Q-loop/lid; other site 991791006514 ABC transporter signature motif; other site 991791006515 Walker B; other site 991791006516 D-loop; other site 991791006517 H-loop/switch region; other site 991791006518 ABC-type transport system involved in multi-copper enzyme maturation, permease component [General function prediction only]; Region: NosY; COG1277 991791006519 ABC-2 family transporter protein; Region: ABC2_membrane_4; pfam12730 991791006520 ABC-type transport system involved in multi-copper enzyme maturation, permease component [General function prediction only]; Region: NosY; COG1277 991791006521 ABC-2 family transporter protein; Region: ABC2_membrane_4; pfam12730 991791006522 Peptidase_C39 like family; Region: Peptidase_C39_2; pfam13529 991791006523 putative active site [active] 991791006524 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3584 991791006525 Phosphatidylglycerophosphate synthase [Lipid metabolism]; Region: PgsA; COG0558 991791006526 AAA-like domain; Region: AAA_10; pfam12846 991791006527 PrgI family protein; Region: PrgI; pfam12666 991791006528 DNA-directed RNA polymerase, sigma subunit (sigma70/sigma32) [Transcription]; Region: RpoD; COG0568 991791006529 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 991791006530 Winged helix-turn helix; Region: HTH_29; pfam13551 991791006531 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 991791006532 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 991791006533 non-specific DNA binding site [nucleotide binding]; other site 991791006534 salt bridge; other site 991791006535 sequence-specific DNA binding site [nucleotide binding]; other site 991791006536 Beta-lactamase enzyme family; Region: Beta-lactamase2; cl17872 991791006537 D-alanyl-D-alanine carboxypeptidase [Cell envelope biogenesis, outer membrane]; Region: DacC; COG1686 991791006538 Penicillin-binding protein 5, C-terminal domain; Region: PBP5_C; cl06814 991791006539 Protein of unknown function (DUF2953); Region: DUF2953; pfam11167 991791006540 sporulation protein YtfJ; Region: spore_ytfJ; TIGR02874 991791006541 segregation and condensation protein B; Reviewed; Region: scpB; PRK00135 991791006542 segregation and condensation protein A; Reviewed; Region: scpA; PRK00104 991791006543 tRNA nucleotidyltransferase/poly(A) polymerase [Translation, ribosomal structure and biogenesis]; Region: PcnB; COG0617 991791006544 Nucleotidyltransferase (NT) domain of ClassII CCA-adding enzymes; Region: NT_ClassII-CCAase; cd05398 991791006545 active site 991791006546 NTP binding site [chemical binding]; other site 991791006547 metal binding triad [ion binding]; metal-binding site 991791006548 Beta-lactamase enzyme family; Region: Beta-lactamase2; cl17872 991791006549 D-alanyl-D-alanine carboxypeptidase [Cell envelope biogenesis, outer membrane]; Region: DacC; COG1686 991791006550 Penicillin-binding protein 5, C-terminal domain; Region: PBP5_C; pfam07943 991791006551 purine nucleoside phosphorylase; Provisional; Region: PRK08202 991791006552 phosphopentomutase; Provisional; Region: PRK05362 991791006553 Metalloenzyme superfamily; Region: Metalloenzyme; pfam01676 991791006554 XerD and XerC integrases, DNA breaking-rejoining enzymes, N- and C-terminal domains. XerD-like integrases are involved in the site-specific integration and excision of lysogenic bacteriophage genomes, transposition of conjugative transposons, termination...; Region: INT_XerDC; cd00798 991791006555 tyrosine recombinase XerD; Region: recomb_XerD; TIGR02225 991791006556 active site 991791006557 Int/Topo IB signature motif; other site 991791006558 stage II sporulation protein M; Region: spo_II_M; TIGR02831 991791006559 sporulation transcription factor Spo0A; Region: spore_0_A; TIGR02875 991791006560 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 991791006561 active site 991791006562 phosphorylation site [posttranslational modification] 991791006563 intermolecular recognition site; other site 991791006564 dimerization interface [polypeptide binding]; other site 991791006565 Sporulation initiation factor Spo0A C terminal; Region: Spo0A_C; pfam08769 991791006566 stage IV sporulation protein B; Region: spore_IV_B; TIGR02860 991791006567 PDZ domain of bacterial and plant zinc metalloprotases, presumably membrane-associated or integral membrane proteases, which may be involved in signalling and regulatory mechanisms. May be responsible for substrate recognition and/or binding, as most PDZ...; Region: PDZ_metalloprotease; cd00989 991791006568 protein binding site [polypeptide binding]; other site 991791006569 SpoIVB peptidase S55; Region: Peptidase_S55; pfam05580 991791006570 ATPase involved in DNA repair [DNA replication, recombination, and repair]; Region: RecN; COG0497 991791006571 ATP-binding cassette domain of RecN; Region: ABC_RecN; cd03241 991791006572 Walker A/P-loop; other site 991791006573 ATP binding site [chemical binding]; other site 991791006574 Q-loop/lid; other site 991791006575 ATP-binding cassette domain of RecN; Region: ABC_RecN; cd03241 991791006576 ABC transporter signature motif; other site 991791006577 Walker B; other site 991791006578 D-loop; other site 991791006579 H-loop/switch region; other site 991791006580 arginine repressor; Provisional; Region: argR; PRK00441 991791006581 Arginine repressor, DNA binding domain; Region: Arg_repressor; pfam01316 991791006582 Arginine repressor, C-terminal domain; Region: Arg_repressor_C; pfam02863 991791006583 NAD kinase [Coenzyme metabolism]; Region: nadF; COG0061 991791006584 ATP-NAD kinase; Region: NAD_kinase; pfam01513 991791006585 Predicted rRNA methylase [Translation, ribosomal structure and biogenesis]; Region: COG1189 991791006586 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 991791006587 RNA binding surface [nucleotide binding]; other site 991791006588 FtsJ-like methyltransferase; Region: FtsJ; pfam01728 991791006589 Deoxyxylulose-5-phosphate synthase [Coenzyme metabolism / Lipid metabolism]; Region: Dxs; COG1154 991791006590 Thiamine pyrophosphate (TPP) family, DXS subfamily, TPP-binding module; 1-Deoxy-D-xylulose-5-phosphate synthase (DXS) is a regulatory enzyme of the mevalonate-independent pathway involved in terpenoid biosynthesis. Terpeniods are plant natural products...; Region: TPP_DXS; cd02007 991791006591 TPP-binding site; other site 991791006592 Pyrimidine (PYR) binding domain of 1-deoxy-D-xylulose-5-phosphate synthase (DXS), transketolase (TK), and related proteins; Region: TPP_PYR_DXS_TK_like; cd07033 991791006593 PYR/PP interface [polypeptide binding]; other site 991791006594 dimer interface [polypeptide binding]; other site 991791006595 TPP binding site [chemical binding]; other site 991791006596 Transketolase, C-terminal domain; Region: Transketolase_C; pfam02780 991791006597 Geranylgeranyl pyrophosphate synthase [Coenzyme metabolism]; Region: IspA; COG0142 991791006598 Trans-Isoprenyl Diphosphate Synthases, head-to-tail; Region: Trans_IPPS_HT; cd00685 991791006599 substrate binding pocket [chemical binding]; other site 991791006600 chain length determination region; other site 991791006601 substrate-Mg2+ binding site; other site 991791006602 catalytic residues [active] 991791006603 aspartate-rich region 1; other site 991791006604 active site lid residues [active] 991791006605 aspartate-rich region 2; other site 991791006606 exodeoxyribonuclease VII small subunit; Provisional; Region: PRK00977 991791006607 Exonuclease VII, large subunit [DNA replication, recombination, and repair]; Region: XseA; COG1570 991791006608 ExoVII_LU_OBF: A subfamily of OB folds corresponding to the N-terminal OB-fold domain of Escherichia coli exodeoxyribonuclease VII (ExoVII) large subunit. E. coli ExoVII is composed of two non-identical subunits. E. coli ExoVII is a...; Region: ExoVII_LU_OBF; cd04489 991791006609 generic binding surface I; other site 991791006610 generic binding surface II; other site 991791006611 bifunctional 5,10-methylene-tetrahydrofolate dehydrogenase/ 5,10-methylene-tetrahydrofolate cyclohydrolase; Provisional; Region: PRK14172 991791006612 Tetrahydrofolate dehydrogenase/cyclohydrolase, catalytic domain; Region: THF_DHG_CYH; pfam00763 991791006613 NADP binding domain of methylene-tetrahydrofolate dehydrogenase/cyclohydrolase; Region: NAD_bind_m-THF_DH_Cyclohyd; cd01080 991791006614 homodimer interface [polypeptide binding]; other site 991791006615 NADP binding site [chemical binding]; other site 991791006616 substrate binding site [chemical binding]; other site 991791006617 transcription antitermination protein NusB; Reviewed; Region: nusB; PRK00202 991791006618 putative RNA binding site [nucleotide binding]; other site 991791006619 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG1302 991791006620 SpoIIIAH-like protein; Region: SpoIIIAH; pfam12685 991791006621 stage III sporulation protein AG; Region: spore_III_AG; TIGR02830 991791006622 stage III sporulation protein AF; Region: spore_III_AF; TIGR02896 991791006623 stage III sporulation protein AE; Region: spore_III_AE; TIGR02829 991791006624 stage III sporulation protein AD; Region: spore_III_AD; TIGR02849 991791006625 stage III sporulation protein AC; Region: spore_III_AC; TIGR02848 991791006626 stage III sporulation protein AB; Region: spore_III_AB; TIGR02833 991791006627 ncharacterized protein conserved in bacteria [Function unknown]; Region: SpoIIIAA; COG3854 991791006628 RecA-like NTPases. This family includes the NTP binding domain of F1 and V1 H+ATPases, DnaB and related helicases as well as bacterial RecA and related eukaryotic and archaeal recombinases. This group also includes bacterial conjugation proteins and...; Region: RecA-like_NTPases; cl17233 991791006629 elongation factor P; Validated; Region: PRK00529 991791006630 Elongation factor P (EF-P) KOW-like domain; Region: EFP_N; pfam08207 991791006631 S1_EF-P_repeat_1: Translation elongation factor P (EF-P), S1-like RNA-binding domain, repeat 1. EF-P stimulates the peptidyltransferase activity in the prokaryotic 70S ribosome. EF-P enhances the synthesis of certain dipeptides with...; Region: S1_EF-P_repeat_1; cd04470 991791006632 RNA binding site [nucleotide binding]; other site 991791006633 S1_EF-P_repeat_2: Translation elongation factor P (EF-P), S1-like RNA-binding domain, repeat 1. EF-P stimulates the peptidyltransferase activity in the prokaryotic 70S ribosome. EF-P enhances the synthesis of certain dipeptides with...; Region: S1_EF-P_repeat_2; cd05794 991791006634 RNA binding site [nucleotide binding]; other site 991791006635 Xaa-Pro aminopeptidase [Amino acid transport and metabolism]; Region: PepP; COG0006 991791006636 Creatinase/Prolidase N-terminal domain; Region: Creatinase_N; pfam01321 991791006637 Similar to Prolidase and Aminopeptidase P. The members of this subfamily presumably catalyse hydrolysis of Xaa-Pro dipeptides and/or release of any N-terminal amino acid, including proline, that is linked with proline; Region: APP-like; cd01092 991791006638 active site 991791006639 Type II secretory pathway, pseudopilin PulG [Cell motility and secretion / Intracellular trafficking and secretion]; Region: PulG; COG2165 991791006640 Type IV pilin N-term methylation site GFxxxE; Region: N_methyl_2; cl06830 991791006641 Type II secretory pathway, pseudopilin PulG [Cell motility and secretion / Intracellular trafficking and secretion]; Region: PulG; COG2165 991791006642 Type II secretory pathway, pseudopilin PulG [Cell motility and secretion / Intracellular trafficking and secretion]; Region: PulG; COG2165 991791006643 Type II secretory pathway, component PulF [Cell motility and secretion / Intracellular trafficking and secretion]; Region: PulF; COG1459 991791006644 Type II secretion system (T2SS), protein F; Region: T2SF; pfam00482 991791006645 Type II secretion system (T2SS), protein F; Region: T2SF; pfam00482 991791006646 Type II secretory pathway, ATPase PulE/Tfp pilus assembly pathway, ATPase PilB [Cell motility and secretion / Intracellular trafficking and secretion]; Region: PulE; COG2804 991791006647 PulE/GspE The type II secretory pathway is the main terminal branch of the general secretory pathway (GSP). It is responsible for the export the majority of Gram-negative bacterial exoenzymes and toxins. PulE is a cytoplasmic protein of the GSP, which...; Region: PulE-GspE; cd01129 991791006648 Walker A motif; other site 991791006649 ATP binding site [chemical binding]; other site 991791006650 Walker B motif; other site 991791006651 Bacterial surface proteins containing Ig-like domains [Cell motility and secretion]; Region: COG5492 991791006652 Bacterial Ig-like domain (group 2); Region: Big_2; pfam02368 991791006653 Xenobiotic acyltransferase (XAT): The XAT class of hexapeptide acyltransferases is composed of a large number of microbial enzymes that catalyze the CoA-dependent acetylation of a variety of hydroxyl-bearing acceptors such as chloramphenicol and...; Region: LbH_XAT; cd03349 991791006654 trimer interface [polypeptide binding]; other site 991791006655 active site 991791006656 substrate binding site [chemical binding]; other site 991791006657 CoA binding site [chemical binding]; other site 991791006658 GAF domain-containing protein [Signal transduction mechanisms]; Region: COG1956 991791006659 GAF domain; Region: GAF_2; pfam13185 991791006660 Fibronectin-binding protein A N-terminus (FbpA); Region: FbpA; pfam05833 991791006661 Domain of unknown function (DUF814); Region: DUF814; pfam05670 991791006662 uracil transporter; Provisional; Region: PRK10720 991791006663 Pyrimidine operon attenuation protein/uracil phosphoribosyltransferase [Nucleotide transport and metabolism]; Region: PyrR; COG2065 991791006664 bifunctional pyrimidine regulatory protein PyrR uracil phosphoribosyltransferase; Provisional; Region: PRK05205 991791006665 Pseudouridylate synthases, 23S RNA-specific [Translation, ribosomal structure and biogenesis]; Region: RluA; COG0564 991791006666 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 991791006667 RNA binding surface [nucleotide binding]; other site 991791006668 Pseudouridine synthase, RsuA/RluD family; Region: PseudoU_synth_RluCD_like; cd02869 991791006669 active site 991791006670 lipoprotein signal peptidase; Provisional; Region: PRK14791 991791006671 lipoprotein signal peptidase; Provisional; Region: PRK14787 991791006672 regulatory protein, yteA family; Region: bacill_yteA; TIGR02890 991791006673 5'-methylthioadenosine/S-adenosylhomocysteine nucleosidase; Validated; Region: PRK05584 991791006674 5'-methylthioadenosine/S-adenosylhomocysteine nucleosidase; Region: MTA/SAH-Nsdase; TIGR01704 991791006675 DivIVA protein; Region: DivIVA; pfam05103 991791006676 DivIVA domain; Region: DivI1A_domain; TIGR03544 991791006677 YGGT family; Region: YGGT; pfam02325 991791006678 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG1799 991791006679 Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzymes, YBL036c-like proteins; Region: PLPDE_III_YBL036c_like; cd00635 991791006680 pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site 991791006681 catalytic residue [active] 991791006682 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3879 991791006683 Bacterial protein of unknown function (DUF881); Region: DUF881; pfam05949 991791006684 Uncharacterized conserved protein (small basic protein) [Function unknown]; Region: Sbp; COG3856 991791006685 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3879 991791006686 Bacterial protein of unknown function (DUF881); Region: DUF881; pfam05949 991791006687 Cell division septal protein [Cell envelope biogenesis, outer membrane]; Region: FtsQ; COG1589 991791006688 POTRA domain, FtsQ-type; Region: POTRA_1; pfam08478 991791006689 Cell cycle protein; Region: FTSW_RODA_SPOVE; cl00511 991791006690 phospho-N-acetylmuramoyl-pentapeptide-transferase; Provisional; Region: mraY; PRK00108 991791006691 Phospho-N-acetylmuramoyl-pentapeptide-transferase (mraY) is an enzyme responsible for the formation of the first lipid intermediate in the synthesis of bacterial cell wall peptidoglycan. It catalyzes the formation of...; Region: GT_MraY; cd06852 991791006692 Mg++ binding site [ion binding]; other site 991791006693 putative catalytic motif [active] 991791006694 putative substrate binding site [chemical binding]; other site 991791006695 UDP-N-acetylmuramyl pentapeptide synthase [Cell envelope biogenesis, outer membrane]; Region: MurF; COG0770 991791006696 Mur ligase family, catalytic domain; Region: Mur_ligase; pfam01225 991791006697 Mur ligase middle domain; Region: Mur_ligase_M; pfam08245 991791006698 Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875 991791006699 UDP-N-acetylmuramoylalanyl-D-glutamate--2, 6-diaminopimelate ligase; Provisional; Region: murE; PRK00139 991791006700 Mur ligase family, catalytic domain; Region: Mur_ligase; pfam01225 991791006701 Mur ligase middle domain; Region: Mur_ligase_M; pfam08245 991791006702 Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875 991791006703 stage V sporulation protein D; Region: spoVD_pbp; TIGR02214 991791006704 Penicillin-binding Protein dimerisation domain; Region: PBP_dimer; pfam03717 991791006705 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; pfam00905 991791006706 PASTA domain of PBP2x-like proteins, first repeat. Penicillin-binding proteins (PBPs) are the major targets for beta-lactam antibiotics, like penicillins and cephalosporins. Beta-lactam antibiotics specifically inhibit transpeptidase activity by...; Region: PASTA_Pbp2x-like_1; cd06576 991791006707 PASTA domain of PBP2x-like proteins, second repeat. Penicillin-binding proteins (PBPs) are the major targets for beta-lactam antibiotics, like penicillins and cephalosporins. Beta-lactam antibiotics specifically inhibit transpeptidase activity by...; Region: PASTA_Pbp2x-like_2; cd06575 991791006708 Septum formation initiator; Region: DivIC; cl17659 991791006709 MraW methylase family; Region: Methyltransf_5; pfam01795 991791006710 16S rRNA m(4)C1402 methyltranserfase; Provisional; Region: PRK00050 991791006711 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2001 991791006712 MraZ protein; Region: MraZ; pfam02381 991791006713 MraZ protein; Region: MraZ; pfam02381 991791006714 GTP-binding protein YchF; Reviewed; Region: PRK09601 991791006715 YchF GTPase; Region: YchF; cd01900 991791006716 G1 box; other site 991791006717 GTP/Mg2+ binding site [chemical binding]; other site 991791006718 Switch I region; other site 991791006719 G2 box; other site 991791006720 Switch II region; other site 991791006721 G3 box; other site 991791006722 G4 box; other site 991791006723 G5 box; other site 991791006724 TGS_YchF_C: This subfamily represents TGS domain-containing YchF GTP-binding protein, a universally conserved GTPase whose function is unknown. The N-terminal domain of the YchF protein belongs to the Obg-like family of GTPases, and some members of the...; Region: TGS_YchF_C; cd04867 991791006725 Predicted ATP-dependent protease [Posttranslational modification, protein turnover, chaperones]; Region: LonB; COG1067 991791006726 Lon protease (S16) C-terminal proteolytic domain; Region: Lon_C; pfam05362 991791006727 Cation transport ATPase [Inorganic ion transport and metabolism]; Region: MgtA; COG0474 991791006728 Cation transporter/ATPase, N-terminus; Region: Cation_ATPase_N; smart00831 991791006729 E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122 991791006730 Putative hydrolase of sodium-potassium ATPase alpha subunit; Region: Hydrolase_like2; pfam13246 991791006731 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 991791006732 motif II; other site 991791006733 Cation transporting ATPase, C-terminus; Region: Cation_ATPase_C; pfam00689 991791006734 putative manganese-dependent inorganic pyrophosphatase; Provisional; Region: PRK05427 991791006735 The CBS domain, named after human CBS, is a small domain originally identified in cystathionine beta-synthase and is subsequently found in a wide range of different proteins. CBS domains usually occur in tandem repeats. They associate to form a so-called...; Region: CBS_pair; cl15354 991791006736 DHHA2 domain; Region: DHHA2; pfam02833 991791006737 flagellar basal body rod protein FlgG; Reviewed; Region: flgG; PRK12817 991791006738 Flagella basal body rod protein; Region: Flg_bb_rod; pfam00460 991791006739 Flagellar basal body rod FlgEFG protein C-terminal; Region: Flg_bbr_C; pfam06429 991791006740 flagellar basal body rod protein FlgG; Reviewed; Region: flgG; PRK12818 991791006741 Flagella basal body rod protein; Region: Flg_bb_rod; pfam00460 991791006742 Flagellar basal body rod FlgEFG protein C-terminal; Region: Flg_bbr_C; pfam06429 991791006743 RNA polymerase sigma factor, FliA/WhiG family; Region: FliA_WhiG; TIGR02479 991791006744 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 991791006745 Sigma-70 region 3; Region: Sigma70_r3; pfam04539 991791006746 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 991791006747 DNA binding residues [nucleotide binding] 991791006748 c-di-GMP-binding protein [Signal transduction mechanisms]; Region: COG5581 991791006749 Flagellar protein YcgR; Region: YcgR_2; pfam12945 991791006750 PilZ domain; Region: PilZ; pfam07238 991791006751 Antiactivator of flagellar biosynthesis FleN, an ATPase [Cell motility]; Region: flhG; COG0455 991791006752 FleN is a member of the Fer4_NifH superfamily. It shares the common function as an ATPase, with the ATP-binding domain at the N-terminus. In Pseudomonas aeruginosa, FleN gene is involved in regulating the number of flagella and chemotactic motility by...; Region: FleN-like; cd02038 991791006753 P-loop; other site 991791006754 flagellar biosynthesis regulator FlhF; Validated; Region: flhF; PRK05703 991791006755 The Fer4_NifH superfamily contains a variety of proteins which share a common ATP-binding domain. Functionally, proteins in this superfamily use the energy from hydrolysis of NTP to transfer electron or ion; Region: Fer4_NifH; cl17203 991791006756 flagellar biosynthesis protein FlhA; Validated; Region: flhA; PRK06012 991791006757 FHIPEP family; Region: FHIPEP; pfam00771 991791006758 bifunctional flagellar biosynthesis protein FliR/FlhB; Provisional; Region: PRK12772 991791006759 Flagellar biosynthesis pathway, component FliR [Cell motility and secretion / Intracellular trafficking and secretion]; Region: FliR; COG1684 991791006760 Uncharacterized homolog of the cytoplasmic domain of flagellar protein FhlB [Function unknown]; Region: COG2257 991791006761 Flagellar biosynthesis pathway, component FliQ [Cell motility and secretion / Intracellular trafficking and secretion]; Region: FliQ; COG1987 991791006762 flagellar biosynthesis protein FliP; Reviewed; Region: fliP; PRK05699 991791006763 flagellar biosynthetic protein FliO; Region: FliO_TIGR; TIGR03500 991791006764 Flagellar basal body-associated protein FliL; Region: FliL; pfam03748 991791006765 Flagellar protein (FlbD); Region: FlbD; pfam06289 991791006766 Flagellar hook protein FlgE [Cell motility and secretion]; Region: FlgE; COG1749 991791006767 Flagella basal body rod protein; Region: Flg_bb_rod; pfam00460 991791006768 Flagellar basal body rod FlgEFG protein C-terminal; Region: Flg_bbr_C; cl15855 991791006769 Flagellar basal body rod FlgEFG protein C-terminal; Region: Flg_bbr_C; pfam06429 991791006770 Protein of unknown function (DUF3766); Region: DUF3766; cl11797 991791006771 Flagellar hook capping protein [Cell motility and secretion]; Region: FlgD; COG1843 991791006772 Flagellar hook capping protein - N-terminal region; Region: FlgD; pfam03963 991791006773 Flagellar hook-length control protein [Cell motility and secretion]; Region: FliK; COG3144 991791006774 Flagellar hook-length control protein FliK; Region: Flg_hook; pfam02120 991791006775 Flagellar biosynthesis chaperone [Cell motility and secretion / Intracellular trafficking and secretion / Posttranslational modification, protein turnover, chaperones]; Region: FliJ; COG2882 991791006776 Flagellar biosynthesis/type III secretory pathway ATPase [Cell motility and secretion / Intracellular trafficking and secretion]; Region: FliI; COG1157 991791006777 ATP synthase alpha/beta family, beta-barrel domain; Region: ATP-synt_ab_N; pfam02874 991791006778 Flagellum-specific ATPase/type III secretory pathway virulence-related protein. This group of ATPases are responsible for the export of flagellum and virulence-related proteins. The bacterial flagellar motor is similar to the F0F1-ATPase, in that they...; Region: ATPase_flagellum-secretory_path_III; cd01136 991791006779 Walker A motif/ATP binding site; other site 991791006780 Walker B motif; other site 991791006781 Flagellar biosynthesis/type III secretory pathway protein [Cell motility and secretion / Intracellular trafficking and secretion]; Region: FliH; COG1317 991791006782 flagellar motor switch protein G; Validated; Region: fliG; PRK05686 991791006783 FliG C-terminal domain; Region: FliG_C; pfam01706 991791006784 Flagellar basal body M-ring protein [Cell motility and secretion]; Region: fliF; COG1766 991791006785 Secretory protein of YscJ/FliF family; Region: YscJ_FliF; cl01907 991791006786 Flagellar M-ring protein C-terminal; Region: YscJ_FliF_C; pfam08345 991791006787 flagellar hook-basal body protein FliE; Provisional; Region: fliE; PRK12728 991791006788 flagellar basal-body rod protein FlgC; Region: FlgC; TIGR01395 991791006789 Flagellar basal body rod FlgEFG protein C-terminal; Region: Flg_bbr_C; pfam06429 991791006790 flagellar basal body rod protein FlgB; Provisional; Region: flgB; PRK12623 991791006791 Nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: WcaG; COG0451 991791006792 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 991791006793 NAD(P) binding site [chemical binding]; other site 991791006794 active site 991791006795 flagellin; Provisional; Region: PRK12804 991791006796 Bacterial flagellin N-terminal helical region; Region: Flagellin_N; pfam00669 991791006797 Bacterial flagellin C-terminal helical region; Region: Flagellin_C; pfam00700 991791006798 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2604 991791006799 UDP-galactopyranose mutase [Cell envelope biogenesis, outer membrane]; Region: Glf; COG0562 991791006800 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450 991791006801 UDP-galactopyranose mutase; Region: GLF; pfam03275 991791006802 Predicted glycosyltransferases [General function prediction only]; Region: COG1216 991791006803 Subfamily of Glycosyltransferase Family GT2 of unknown function; Region: GT_2_like_c; cd04186 991791006804 Probable Catalytic site; other site 991791006805 metal-binding site 991791006806 Predicted glycosyltransferases [General function prediction only]; Region: COG1216 991791006807 Subfamily of Glycosyltransferase Family GT2 of unknown function; Region: GT_2_like_c; cd04186 991791006808 Probable Catalytic site; other site 991791006809 metal-binding site 991791006810 Glycosyltransferase like family 2; Region: Glyco_tranf_2_3; pfam13641 991791006811 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394 991791006812 active site 991791006813 Glycosyltransferases, probably involved in cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: COG1215 991791006814 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394 991791006815 active site 991791006816 Glycosyltransferases involved in cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WcaA; COG0463 991791006817 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394 991791006818 active site 991791006819 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cd00761 991791006820 active site 991791006821 Glycosyl transferases group 1; Region: Glyco_trans_1_4; pfam13692 991791006822 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4641 991791006823 Glycosyl transferases group 1; Region: Glyco_trans_1_2; pfam13524 991791006824 Predicted pyridoxal phosphate-dependent enzyme apparently involved in regulation of cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WecE; COG0399 991791006825 3-amino-5-hydroxybenzoic acid synthase family (AHBA_syn). AHBA_syn family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The members of this CD are involved in various biosynthetic pathways for secondary...; Region: AHBA_syn; cd00616 991791006826 inhibitor-cofactor binding pocket; inhibition site 991791006827 pyridoxal 5'-phosphate binding site [chemical binding]; other site 991791006828 catalytic residue [active] 991791006829 GDP-fucose synthetase, extended (e) SDRs; Region: GDP_FS_SDR_e; cd05239 991791006830 GDP-4-keto-6-deoxymannose-3, 5-epimerase-4-reductase; Region: PLN02725 991791006831 NADP binding site [chemical binding]; other site 991791006832 active site 991791006833 putative substrate binding site [chemical binding]; other site 991791006834 GDP-D-mannose dehydratase [Cell envelope biogenesis, outer membrane]; Region: Gmd; COG1089 991791006835 GDP-mannose 4,6 dehydratase, extended (e) SDRs; Region: GDP_MD_SDR_e; cd05260 991791006836 NADP-binding site; other site 991791006837 homotetramer interface [polypeptide binding]; other site 991791006838 substrate binding site [chemical binding]; other site 991791006839 homodimer interface [polypeptide binding]; other site 991791006840 active site 991791006841 Putative motility protein; Region: YjfB_motility; pfam14070 991791006842 Exopolysaccharide biosynthesis protein [Cell envelope biogenesis, outer membrane]; Region: COG3955 991791006843 Exopolysaccharide biosynthesis protein [Cell envelope biogenesis, outer membrane]; Region: COG3955 991791006844 Spore coat polysaccharide biosynthesis protein, predicted glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: spsG; COG3980 991791006845 Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013 991791006846 pseudaminic acid synthase; Region: PseI; TIGR03586 991791006847 NeuB family; Region: NeuB; pfam03102 991791006848 C-terminal SAF domain of sialic acid synthetase; Region: SAF_NeuB_like; cd11615 991791006849 NeuB binding interface [polypeptide binding]; other site 991791006850 putative substrate binding site [chemical binding]; other site 991791006851 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 991791006852 Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013 991791006853 carbamoyl phosphate synthase-like protein; Provisional; Region: PRK12767 991791006854 ATP-grasp domain; Region: ATP-grasp_3; pfam02655 991791006855 SpsF is a glycosyltrnasferase implicated in the synthesis of the spore coat; Region: GT2_SpsF; cd02518 991791006856 ligand binding site; other site 991791006857 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 991791006858 motif II; other site 991791006859 Methylmalonyl-CoA epimerase (MMCE); Region: MMCE; cd07249 991791006860 dimer interface [polypeptide binding]; other site 991791006861 substrate binding site [chemical binding]; other site 991791006862 metal binding site [ion binding]; metal-binding site 991791006863 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4641 991791006864 DUF based on E. rectale Gene description (DUF3880); Region: DUF3880; pfam12996 991791006865 Glycosyl transferases group 1; Region: Glyco_trans_1_2; pfam13524 991791006866 UDP-Glcnac (UDP-linked N-acetylglucosamine) inverting 4,6-dehydratase, extended (e) SDRs; Region: UDP_invert_4-6DH_SDR_e; cd05237 991791006867 Polysaccharide biosynthesis protein; Region: Polysacc_synt_2; pfam02719 991791006868 NAD(P) binding site [chemical binding]; other site 991791006869 homodimer interface [polypeptide binding]; other site 991791006870 substrate binding site [chemical binding]; other site 991791006871 active site 991791006872 Uncharacterized protein conserved in bacteria with an aminopeptidase-like domain [General function prediction only]; Region: COG4310 991791006873 M28 Zn-Peptidases; Region: M28_like_3; cd05644 991791006874 active site 991791006875 metal binding site [ion binding]; metal-binding site 991791006876 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2604 991791006877 Aminoglycoside N3'-acetyltransferase [Defense mechanisms]; Region: COG2746 991791006878 Acyl carrier protein [Lipid metabolism / Secondary metabolites biosynthesis, transport, and catabolism]; Region: AcpP; COG0236 991791006879 Predicted enzyme involved in methoxymalonyl-ACP biosynthesis [Secondary metabolites biosynthesis, transport, and catabolism]; Region: FkbH; COG3882 991791006880 Acid Phosphatase; Region: Acid_PPase; cl17256 991791006881 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2604 991791006882 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2604 991791006883 flagellin; Provisional; Region: PRK12804 991791006884 Bacterial flagellin N-terminal helical region; Region: Flagellin_N; pfam00669 991791006885 Bacterial flagellin C-terminal helical region; Region: Flagellin_C; pfam00700 991791006886 Flagellar capping protein [Cell motility and secretion]; Region: FliD; COG1345 991791006887 Flagellar hook-associated protein 2 C-terminus; Region: FliD_N; pfam02465 991791006888 Flagellar hook-associated protein 2 C-terminus; Region: FliD_C; pfam07195 991791006889 Flagellin-specific chaperone FliS [Cell motility and secretion / Intracellular trafficking and secretion / Posttranslational modification, protein turnover, chaperones]; Region: FliS; COG1516 991791006890 Uncharacterized flagellar protein FlaG [Cell motility and secretion]; Region: FlaG; COG1334 991791006891 RNA-binding global regulator CsrA [Signal transduction mechanisms]; Region: CsrA; COG1551 991791006892 flagellar assembly protein FliW; Provisional; Region: PRK13285 991791006893 Flagellin and related hook-associated proteins [Cell motility and secretion]; Region: FlgL; COG1344 991791006894 Bacterial flagellin N-terminal helical region; Region: Flagellin_N; pfam00669 991791006895 Bacterial flagellin C-terminal helical region; Region: Flagellin_C; pfam00700 991791006896 Flagellar hook-associated protein [Cell motility and secretion]; Region: FlgK; COG1256 991791006897 Flagella basal body rod protein; Region: Flg_bb_rod; pfam00460 991791006898 Flagellar basal body rod FlgEFG protein C-terminal; Region: Flg_bbr_C; pfam06429 991791006899 FlgN protein; Region: FlgN; pfam05130 991791006900 Negative regulator of flagellin synthesis (anti-sigma28 factor) [Transcription / Cell motility and secretion / Intracellular trafficking and secretion]; Region: FlgM; COG2747 991791006901 flagellar motor switch protein; Validated; Region: PRK08119 991791006902 CheC-like family; Region: CheC; pfam04509 991791006903 CheC-like family; Region: CheC; pfam04509 991791006904 flagellar motor switch protein FliN; Region: fliN; TIGR02480 991791006905 Flagellar motor switch protein [Cell motility and secretion]; Region: FliM; COG1868 991791006906 Surface presentation of antigens (SPOA); Region: SpoA; pfam01052 991791006907 Chemotaxis signal transduction protein [Cell motility and secretion / Signal transduction mechanisms]; Region: CheW; COG0835 991791006908 Response regulator receiver domain; Region: Response_reg; pfam00072 991791006909 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 991791006910 active site 991791006911 phosphorylation site [posttranslational modification] 991791006912 intermolecular recognition site; other site 991791006913 dimerization interface [polypeptide binding]; other site 991791006914 Chemotaxis protein CheC, inhibitor of MCP methylation [Cell motility and secretion / Signal transduction mechanisms]; Region: CheC; COG1776 991791006915 CheC-like family; Region: CheC; pfam04509 991791006916 CheC-like family; Region: CheC; pfam04509 991791006917 Chemotaxis protein histidine kinase and related kinases [Cell motility and secretion / Signal transduction mechanisms]; Region: CheA; COG0643 991791006918 Histidine Phosphotransfer domain, involved in signalling through a two part component systems in which an autophosphorylating histidine protein kinase serves as a phosphoryl donor to a response regulator protein; the response regulator protein is...; Region: HPT; cd00088 991791006919 putative binding surface; other site 991791006920 active site 991791006921 P2 response regulator binding domain; Region: P2; pfam07194 991791006922 Signal transducing histidine kinase, homodimeric domain; Region: H-kinase_dim; pfam02895 991791006923 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 991791006924 ATP binding site [chemical binding]; other site 991791006925 Mg2+ binding site [ion binding]; other site 991791006926 G-X-G motif; other site 991791006927 CheA regulatory domain; CheA is a histidine protein kinase present in bacteria and archea. Activated by the chemotaxis receptor a histidine phosphoryl group from CheA is passed directly to an aspartate in the response regulator CheY. This signalling...; Region: CheA_reg; cd00731 991791006928 Methylase of chemotaxis methyl-accepting proteins [Cell motility and secretion / Signal transduction mechanisms]; Region: CheR; COG1352 991791006929 CheR methyltransferase, all-alpha domain; Region: CheR_N; pfam03705 991791006930 CheR methyltransferase, SAM binding domain; Region: CheR; pfam01739 991791006931 Chemotaxis response regulator containing a CheY-like receiver domain and a methylesterase domain [Cell motility and secretion / Signal transduction mechanisms]; Region: CheB; COG2201 991791006932 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 991791006933 active site 991791006934 phosphorylation site [posttranslational modification] 991791006935 intermolecular recognition site; other site 991791006936 dimerization interface [polypeptide binding]; other site 991791006937 CheB methylesterase; Region: CheB_methylest; pfam01339 991791006938 chemoreceptor glutamine deamidase CheD; Provisional; Region: PRK13490 991791006939 Chemotaxis signal transduction protein [Cell motility and secretion / Signal transduction mechanisms]; Region: CheW; COG0835 991791006940 Uncharacterized conserved protein [Function unknown]; Region: COG1315 991791006941 Branched-chain amino acid aminotransferase/4-amino-4-deoxychorismate lyase [Amino acid transport and metabolism / Coenzyme metabolism]; Region: IlvE; COG0115 991791006942 PyridoxaL 5'-Phosphate Dependent Enzymes class IV (PLPDE_IV). This D-amino acid superfamily, one of five classes of PLPDE, consists of branched-chain amino acid aminotransferases (BCAT), D-amino acid transferases (DAAT), and...; Region: PLPDE_IV; cd00449 991791006943 homodimer interface [polypeptide binding]; other site 991791006944 substrate-cofactor binding pocket; other site 991791006945 pyridoxal 5'-phosphate binding site [chemical binding]; other site 991791006946 catalytic residue [active] 991791006947 Phosphoserine phosphatase [Amino acid transport and metabolism]; Region: SerB; COG0560 991791006948 HAD-superfamily subfamily IB hydrolase, TIGR01490; Region: HAD-SF-IB-hyp1 991791006949 Protein of unknown function (DUF1292); Region: DUF1292; pfam06949 991791006950 pyruvate:ferredoxin (flavodoxin) oxidoreductase, homodimeric; Region: pyruv_ox_red; TIGR02176 991791006951 Pyrimidine (PYR) binding domain of pyruvate ferredoxin oxidoreductase (PFOR), indolepyruvate ferredoxin oxidoreductase alpha subunit (IOR-alpha), and related proteins; Region: TPP_PYR_PFOR_IOR-alpha_like; cd07034 991791006952 dimer interface [polypeptide binding]; other site 991791006953 PYR/PP interface [polypeptide binding]; other site 991791006954 TPP binding site [chemical binding]; other site 991791006955 substrate binding site [chemical binding]; other site 991791006956 Pyruvate:ferredoxin oxidoreductase and related 2-oxoacid:ferredoxin oxidoreductases, gamma subunit [Energy production and conversion]; Region: PorG; COG1014 991791006957 Domain of unknown function; Region: EKR; smart00890 991791006958 4Fe-4S binding domain; Region: Fer4_6; pfam12837 991791006959 The HCP family of iron-sulfur proteins includes hybrid cluster protein (HCP), acetyl-CoA synthase (ACS), and carbon monoxide dehydrogenase (CODH), all of which contain [Fe4-S4] metal clusters at their active sites. These proteins have a conserved...; Region: HCP_like; cl14655 991791006960 Thiamine pyrophosphate (TPP family), PFOR_PNO subfamily, TPP-binding module; composed of proteins similar to the single subunit pyruvate ferredoxin oxidoreductase (PFOR) of Desulfovibrio Africanus, present in bacteria and amitochondriate eukaryotes. This...; Region: TPP_PFOR_PNO; cd03377 991791006961 TPP-binding site [chemical binding]; other site 991791006962 dimer interface [polypeptide binding]; other site 991791006963 Uncharacterized protein with SCP/PR1 domains [Function unknown]; Region: COG2340 991791006964 SCP_bacterial: SCP-like extracellular protein domain, as found in bacteria and archaea. The wider family of SCP containing proteins includes plant pathogenesis-related protein 1 (PR-1), CRISPs, mammalian cysteine-rich secretory proteins, and allergen 5...; Region: SCP_bacterial; cd05379 991791006965 undecaprenyldiphospho-muramoylpentapeptide beta-N-acetylglucosaminyltransferase; Reviewed; Region: PRK12446 991791006966 MurG is an N-acetylglucosaminyltransferase, the last enzyme involved in the intracellular phase of peptidoglycan biosynthesis. It transfers N-acetyl-D-glucosamine (GlcNAc) from UDP-GlcNAc to the C4 hydroxyl of a lipid-linked N-acetylmuramoyl pentapeptide...; Region: GT1_MurG; cd03785 991791006967 active site 991791006968 homodimer interface [polypeptide binding]; other site 991791006969 single-stranded-DNA-specific exonuclease RecJ; Region: recJ; TIGR00644 991791006970 DHH family; Region: DHH; pfam01368 991791006971 DHHA1 domain; Region: DHHA1; pfam02272 991791006972 Predicted tRNA(5-methylaminomethyl-2-thiouridylate) methyltransferase, contains the PP-loop ATPase domain [Translation, ribosomal structure and biogenesis]; Region: TrmU; COG0482 991791006973 tRNA methyl transferase. This family represents tRNA(5-methylaminomethyl-2-thiouridine)-methyltransferase which is involved in the biosynthesis of the modified nucleoside 5-methylaminomethyl-2-thiouridine present in the wobble position of some tRNAs; Region: tRNA_Me_trans; cd01998 991791006974 Ligand Binding Site [chemical binding]; other site 991791006975 Cysteine sulfinate desulfinase/cysteine desulfurase and related enzymes [Amino acid transport and metabolism]; Region: NifS; COG1104 991791006976 cysteine desulfurase NifS; Region: FeS_nifS; TIGR03402 991791006977 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 991791006978 catalytic residue [active] 991791006979 Cysteine synthase [Amino acid transport and metabolism]; Region: CysK; COG0031 991791006980 CBS_like: This subgroup includes Cystathionine beta-synthase (CBS) and Cysteine synthase. CBS is a unique heme-containing enzyme that catalyzes a pyridoxal 5'-phosphate (PLP)-dependent condensation of serine and homocysteine to give cystathionine; Region: CBS_like; cd01561 991791006981 dimer interface [polypeptide binding]; other site 991791006982 pyridoxal 5'-phosphate binding site [chemical binding]; other site 991791006983 catalytic residue [active] 991791006984 Predicted transcriptional regulator [Transcription]; Region: COG1959 991791006985 Transcriptional regulator; Region: Rrf2; cl17282 991791006986 glucose-1-phosphate adenylyltransferase; Provisional; Region: glgC; PRK05293 991791006987 ADP-glucose pyrophosphorylase is involved in the biosynthesis of glycogen or starch; Region: ADP_Glucose_PP; cd02508 991791006988 ligand binding site; other site 991791006989 oligomer interface; other site 991791006990 Glucose-1-phosphate adenylyltransferase, C-terminal Left-handed parallel beta helix (LbH) domain: Glucose-1-phosphate adenylyltransferase is also known as ADP-glucose synthase or ADP-glucose pyrophosphorylase. It catalyzes the first committed and...; Region: LbH_G1P_AT_C; cd04651 991791006991 dimer interface [polypeptide binding]; other site 991791006992 N-terminal domain interface [polypeptide binding]; other site 991791006993 sulfate 1 binding site; other site 991791006994 ADP-glucose pyrophosphorylase [Carbohydrate transport and metabolism]; Region: GlgC; COG0448 991791006995 ADP-glucose pyrophosphorylase is involved in the biosynthesis of glycogen or starch; Region: ADP_Glucose_PP; cd02508 991791006996 ligand binding site; other site 991791006997 oligomer interface; other site 991791006998 Glucose-1-phosphate adenylyltransferase, C-terminal Left-handed parallel beta helix (LbH) domain: Glucose-1-phosphate adenylyltransferase is also known as ADP-glucose synthase or ADP-glucose pyrophosphorylase. It catalyzes the first committed and...; Region: LbH_G1P_AT_C; cd04651 991791006999 dimer interface [polypeptide binding]; other site 991791007000 N-terminal domain interface [polypeptide binding]; other site 991791007001 sulfate 1 binding site; other site 991791007002 glycogen synthase; Provisional; Region: glgA; PRK00654 991791007003 This family is most closely related to the GT1 family of glycosyltransferases. Glycogen synthase catalyzes the formation and elongation of the alpha-1,4-glucose backbone using ADP-glucose, the second and key step of glycogen biosynthesis. This family...; Region: GT1_Glycogen_synthase_DULL1_like; cd03791 991791007004 ADP-binding pocket [chemical binding]; other site 991791007005 homodimer interface [polypeptide binding]; other site 991791007006 The family 20 carbohydrate-binding module (CBM20), also known as the starch-binding domain, is found in a large number of starch degrading enzymes including alpha-amylase, beta-amylase, glucoamylase, and CGTase (cyclodextrin glucanotransferase). CBM20 is...; Region: CBM20; cd05467 991791007007 starch-binding site 2 [chemical binding]; other site 991791007008 starch-binding site 1 [chemical binding]; other site 991791007009 Cation transport ATPase [Inorganic ion transport and metabolism]; Region: ZntA; COG2217 991791007010 Heavy-metal-associated domain (HMA) is a conserved domain of approximately 30 amino acid residues found in a number of proteins that transport or detoxify heavy metals, for example, the CPx-type heavy metal ATPases and copper chaperones. HMA domain...; Region: HMA; cd00371 991791007011 metal-binding site [ion binding] 991791007012 E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122 991791007013 Soluble P-type ATPase [General function prediction only]; Region: COG4087 991791007014 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 991791007015 dimerization interface [polypeptide binding]; other site 991791007016 putative DNA binding site [nucleotide binding]; other site 991791007017 putative Zn2+ binding site [ion binding]; other site 991791007018 Glutamine amidotransferases class-II (GATase) asparagine synthase_B type. Asparagine synthetase B catalyses the ATP-dependent conversion of aspartate to asparagine. This enzyme is a homodimer, with each monomer composed of a glutaminase domain and a...; Region: AsnB; cd00712 991791007019 active site 991791007020 dimer interface [polypeptide binding]; other site 991791007021 Glutamine amidotransferase domain; Region: GATase_6; pfam13522 991791007022 The C-terminal domain of Asparagine Synthase B. This domain is always found associated n-terminal amidotransferase domain. Family members that contain this domain catalyse the conversion of aspartate to asparagine. Asparagine synthetase B catalyzes the...; Region: Asn_Synthase_B_C; cd01991 991791007023 Ligand Binding Site [chemical binding]; other site 991791007024 Molecular Tunnel; other site 991791007025 Predicted hydrolases of the HAD superfamily [General function prediction only]; Region: Cof; COG0561 991791007026 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 991791007027 active site 991791007028 motif I; other site 991791007029 motif II; other site 991791007030 haloacid dehalogenase-like hydrolase; Region: HAD; cl17202 991791007031 Predicted redox protein, regulator of disulfide bond formation [Posttranslational modification, protein turnover, chaperones]; Region: COG1765 991791007032 Lysophospholipase [Lipid metabolism]; Region: PldB; COG2267 991791007033 Putative lysophospholipase; Region: Hydrolase_4; pfam12146 991791007034 TAP-like protein; Region: Abhydrolase_4; pfam08386 991791007035 Site-specific recombinases, DNA invertase Pin homologs [DNA replication, recombination, and repair]; Region: PinR; COG1961 991791007036 Serine Recombinase (SR) family, TndX-like transposase subfamily, catalytic domain; composed of large serine recombinases similar to Clostridium TndX and TnpX transposases. Serine recombinases catalyze site-specific recombination of DNA molecules by a...; Region: SR_TndX_transposase; cd03770 991791007037 putative catalytic residues [active] 991791007038 catalytic nucleophile [active] 991791007039 Recombinase; Region: Recombinase; pfam07508 991791007040 Recombinase zinc beta ribbon domain; Region: Zn_ribbon_recom; pfam13408 991791007041 Asparagine synthase (glutamine-hydrolyzing) [Amino acid transport and metabolism]; Region: AsnB; COG0367 991791007042 The C-terminal domain of Asparagine Synthase B. This domain is always found associated n-terminal amidotransferase domain. Family members that contain this domain catalyse the conversion of aspartate to asparagine. Asparagine synthetase B catalyzes the...; Region: Asn_Synthase_B_C; cd01991 991791007043 Prokaryotic UGPase catalyses the synthesis of UDP-glucose; Region: UGPase_prokaryotic; cd02541 991791007044 dTDP-glucose pyrophosphorylase [Cell envelope biogenesis, outer membrane]; Region: RfbA; COG1209 991791007045 active site 991791007046 tetramer interface; other site 991791007047 4-amino-4-deoxy-L-arabinose transferase and related glycosyltransferases of PMT family [Cell envelope biogenesis, outer membrane]; Region: ArnT; COG1807 991791007048 Dolichyl-phosphate-mannose-protein mannosyltransferase; Region: PMT_2; pfam13231 991791007049 4-amino-4-deoxy-L-arabinose transferase and related glycosyltransferases of PMT family [Cell envelope biogenesis, outer membrane]; Region: ArnT; COG1807 991791007050 Alpha-glucosidases, family 31 of glycosyl hydrolases [Carbohydrate transport and metabolism]; Region: COG1501 991791007051 Glycosyl hydrolases family 31; Region: Glyco_hydro_31; pfam01055 991791007052 active site 991791007053 catalytic site [active] 991791007054 Chitobiase/beta-hexosaminidase C-terminal domain; Region: CHB_HEX_C; pfam03174 991791007055 Fn3 associated; Region: Fn3_assoc; pfam13287 991791007056 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: COG4585 991791007057 Histidine kinase; Region: HisKA_3; pfam07730 991791007058 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 991791007059 ATP binding site [chemical binding]; other site 991791007060 Mg2+ binding site [ion binding]; other site 991791007061 G-X-G motif; other site 991791007062 Response regulator receiver domain; Region: Response_reg; pfam00072 991791007063 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 991791007064 active site 991791007065 phosphorylation site [posttranslational modification] 991791007066 intermolecular recognition site; other site 991791007067 dimerization interface [polypeptide binding]; other site 991791007068 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 991791007069 DNA binding residues [nucleotide binding] 991791007070 ABC-type transport system, involved in lipoprotein release, permease component [Cell envelope biogenesis, outer membrane]; Region: LolE; COG4591 991791007071 ABC-type antimicrobial peptide transport system, permease component [Defense mechanisms]; Region: SalY; COG0577 991791007072 FtsX-like permease family; Region: FtsX; pfam02687 991791007073 ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136 991791007074 ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255 991791007075 Walker A/P-loop; other site 991791007076 ATP binding site [chemical binding]; other site 991791007077 Q-loop/lid; other site 991791007078 ABC transporter signature motif; other site 991791007079 Walker B; other site 991791007080 D-loop; other site 991791007081 H-loop/switch region; other site 991791007082 HTH domain; Region: HTH_11; cl17392 991791007083 Predicted pyridoxal phosphate-dependent enzyme apparently involved in regulation of cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WecE; COG0399 991791007084 3-amino-5-hydroxybenzoic acid synthase family (AHBA_syn). AHBA_syn family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The members of this CD are involved in various biosynthetic pathways for secondary...; Region: AHBA_syn; cd00616 991791007085 inhibitor-cofactor binding pocket; inhibition site 991791007086 pyridoxal 5'-phosphate binding site [chemical binding]; other site 991791007087 catalytic residue [active] 991791007088 Predicted HD-superfamily hydrolase [General function prediction only]; Region: COG3481 991791007089 YhaM_OBF_like: A subfamily of OB folds similar to that found in Bacillus subtilis YhaM and Staphylococcus aureus cmp-binding factor-1 (SaCBF1). Both these proteins are 3'-to-5'exoribonucleases. YhaM requires Mn2+ or Co2+ for activity and is...; Region: YhaM_OBF_like; cd04492 991791007090 generic binding surface II; other site 991791007091 generic binding surface I; other site 991791007092 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 991791007093 Zn2+ binding site [ion binding]; other site 991791007094 Mg2+ binding site [ion binding]; other site 991791007095 helicase-exonuclease AddAB, AddA subunit, Firmicutes type; Region: addA_Gpos; TIGR02785 991791007096 Part of AAA domain; Region: AAA_19; pfam13245 991791007097 Family description; Region: UvrD_C_2; pfam13538 991791007098 CRISPR/Cas system-associated protein Cas4; Region: Cas4_I-A_I-B_I-C_I-D_II-B; cl00641 991791007099 ATP-dependent nuclease, subunit B [DNA replication, recombination, and repair]; Region: AddB; COG3857 991791007100 PD-(D/E)XK nuclease superfamily; Region: PDDEXK_1; pfam12705 991791007101 serine hydroxymethyltransferase; Reviewed; Region: glyA; PRK00011 991791007102 Serine-glycine hydroxymethyltransferase (SHMT). This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). SHMT carries out interconversion of serine and glycine; it catalyzes the transfer of hydroxymethyl...; Region: SHMT; cd00378 991791007103 dimer interface [polypeptide binding]; other site 991791007104 active site 991791007105 glycine-pyridoxal phosphate binding site [chemical binding]; other site 991791007106 folate binding site [chemical binding]; other site 991791007107 Uncharacterized conserved protein [Function unknown]; Region: COG2966 991791007108 Protein of unknown function (DUF1212); Region: DUF1212; pfam06738 991791007109 Glycerol-3-phosphate acyltransferase; Region: G3P_acyltransf; cl00410 991791007110 Uncharacterized conserved protein [Function unknown]; Region: COG3610 991791007111 Transcriptional regulators CsoR (copper-sensitive operon repressor), RcnR, and FrmR, and related domains; this domain superfamily was previously known as DUF156; Region: CsoR-like_DUF156; cd10148 991791007112 putative homotetramer interface [polypeptide binding]; other site 991791007113 putative homodimer interface [polypeptide binding]; other site 991791007114 putative allosteric switch controlling residues; other site 991791007115 putative metal binding site [ion binding]; other site 991791007116 putative homodimer-homodimer interface [polypeptide binding]; other site 991791007117 aspartyl-tRNA synthetase; Validated; Region: aspS; PRK00476 991791007118 EcAspRS_like_N: N-terminal, anticodon recognition domain of the type found in Escherichia coli aspartyl-tRNA synthetase (AspRS), the human mitochondrial (mt) AspRS-2, the discriminating (D) Thermus thermophilus AspRS-1, and the nondiscriminating (ND)...; Region: EcAspRS_like_N; cd04317 991791007119 dimer interface [polypeptide binding]; other site 991791007120 anticodon binding site; other site 991791007121 Asp tRNA synthetase (aspRS) class II core domain. Class II assignment is based upon its structure and the presence of three characteristic sequence motifs. AspRS is a homodimer, which attaches a specific amino acid to the 3' OH group of ribose of...; Region: AspRS_core; cd00777 991791007122 homodimer interface [polypeptide binding]; other site 991791007123 motif 1; other site 991791007124 active site 991791007125 motif 2; other site 991791007126 GAD domain; Region: GAD; pfam02938 991791007127 Asp tRNA synthetase (aspRS) class II core domain. Class II assignment is based upon its structure and the presence of three characteristic sequence motifs. AspRS is a homodimer, which attaches a specific amino acid to the 3' OH group of ribose of...; Region: AspRS_core; cd00777 991791007128 motif 3; other site 991791007129 coproporphyrinogen III oxidase; Provisional; Region: PRK08207 991791007130 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 991791007131 FeS/SAM binding site; other site 991791007132 Zn-dependent hydrolases, including glyoxylases [General function prediction only]; Region: GloB; COG0491 991791007133 D-Tyrosyl-tRNAtyr deacylases; a class of tRNA-dependent hydrolases which are capable of hydrolyzing the ester bond of D-Tyrosyl-tRNA reducing the level of cellular D-Tyrosine while recycling the peptidyl-tRNA; found in bacteria and in eukaryotes but not...; Region: Dtyr_deacylase; cd00563 991791007134 putative active site [active] 991791007135 dimerization interface [polypeptide binding]; other site 991791007136 putative tRNAtyr binding site [nucleotide binding]; other site 991791007137 Guanosine polyphosphate pyrophosphohydrolases/synthetases [Signal transduction mechanisms / Transcription]; Region: SpoT; COG0317 991791007138 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 991791007139 Zn2+ binding site [ion binding]; other site 991791007140 Mg2+ binding site [ion binding]; other site 991791007141 Nucleotidyltransferase (NT) domain of RelA- and SpoT-like ppGpp synthetases and hydrolases; Region: NT_Rel-Spo_like; cd05399 991791007142 synthetase active site [active] 991791007143 NTP binding site [chemical binding]; other site 991791007144 metal binding site [ion binding]; metal-binding site 991791007145 TGS_RelA_SpoT: The RelA (SpoT) protein, also referred to as ppGpp hydrolase/synthetase, is a ribosome-associated protein that is activated during amino acid starvation and thought to mediate the stringent response. RelA contains a TGS domain, named after...; Region: TGS_RelA_SpoT; cd01668 991791007146 ACT domain found C-terminal of the RelA/SpoT domains; Region: ACT_RelA-SpoT; cd04876 991791007147 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 991791007148 active site 991791007149 Single-stranded DNA-specific exonuclease [DNA replication, recombination, and repair]; Region: RecJ; COG0608 991791007150 DHH family; Region: DHH; pfam01368 991791007151 preprotein translocase subunit SecF; Reviewed; Region: secF; PRK13022 991791007152 Protein export membrane protein; Region: SecD_SecF; pfam02355 991791007153 protein-export membrane protein SecD; Region: secD; TIGR01129 991791007154 protein-export membrane protein, SecD/SecF family; Region: 2A0604s01; TIGR00916 991791007155 SCIFF radical SAM maturase; Region: rSAM_six_Cys; TIGR03974 991791007156 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 991791007157 FeS/SAM binding site; other site 991791007158 radical SAM additional 4Fe4S-binding SPASM domain; Region: rSAM_more_4Fe4S; TIGR04085 991791007159 Protein of unknown function (DUF4001); Region: DUF4001; cl14848 991791007160 Protein of unknown function (DUF3792); Region: DUF3792; pfam12670 991791007161 preprotein translocase subunit YajC; Validated; Region: yajC; PRK05585 991791007162 queuine tRNA-ribosyltransferase; Provisional; Region: tgt; PRK00112 991791007163 Queuine/archaeosine tRNA-ribosyltransferase [Translation, ribosomal structure and biogenesis]; Region: Tgt; COG0343 991791007164 S-adenosylmethionine:tRNA ribosyltransferase-isomerase; Provisional; Region: queA; PRK00147 991791007165 S-adenosylmethionine:tRNA ribosyltransferase-isomerase; Region: queA; TIGR00113 991791007166 Holliday junction DNA helicase RuvB; Reviewed; Region: ruvB; PRK00080 991791007167 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 991791007168 Walker A motif; other site 991791007169 ATP binding site [chemical binding]; other site 991791007170 Walker B motif; other site 991791007171 arginine finger; other site 991791007172 Holliday junction DNA helicase ruvB C-terminus; Region: RuvB_C; pfam05491 991791007173 Holliday junction DNA helicase RuvA; Reviewed; Region: ruvA; PRK00116 991791007174 RuvA N terminal domain; Region: RuvA_N; pfam01330 991791007175 RuvA, C-terminal domain; Region: RuvA_C; pfam07499 991791007176 Acyl-CoA reductase LuxC; Region: ALDH_Acyl-CoA-Red_LuxC; cd07080 991791007177 Acyl-CoA reductase (LuxC); Region: LuxC; pfam05893 991791007178 putative catalytic cysteine [active] 991791007179 Acyl-protein synthetase, LuxE; Region: LuxE; pfam04443 991791007180 Biotin carboxyl carrier protein [Lipid metabolism]; Region: AccB; COG0511 991791007181 The biotinyl-domain or biotin carboxyl carrier protein (BCCP) domain is present in all biotin-dependent enzymes, such as acetyl-CoA carboxylase, pyruvate carboxylase, propionyl-CoA carboxylase, methylcrotonyl-CoA carboxylase, geranyl-CoA carboxylase; Region: biotinyl_domain; cd06850 991791007182 carboxyltransferase (CT) interaction site; other site 991791007183 biotinylation site [posttranslational modification]; other site 991791007184 Zinc metalloprotease (elastase) [Amino acid transport and metabolism]; Region: LasB; COG3227 991791007185 Fungalysin/Thermolysin Propeptide Motif; Region: FTP; pfam07504 991791007186 Peptidase propeptide and YPEB domain; Region: PepSY; pfam03413 991791007187 Peptidase M4 family includes thermolysin, protealysin, aureolysin and neutral protease; Region: M4_neutral_protease; cd09597 991791007188 active site 991791007189 Zn binding site [ion binding]; other site 991791007190 Bacterial surface proteins containing Ig-like domains [Cell motility and secretion]; Region: COG5492 991791007191 Clostridial hydrophobic, with a conserved W residue, domain; Region: ChW; smart00728 991791007192 Clostridial hydrophobic, with a conserved W residue, domain; Region: ChW; smart00728 991791007193 Clostridial hydrophobic, with a conserved W residue, domain; Region: ChW; smart00728 991791007194 Clostridial hydrophobic, with a conserved W residue, domain; Region: ChW; smart00728 991791007195 Clostridial hydrophobic, with a conserved W residue, domain; Region: ChW; smart00728 991791007196 Clostridial hydrophobic, with a conserved W residue, domain; Region: ChW; smart00728 991791007197 hypothetical protein; Validated; Region: PRK00110 991791007198 Uncharacterized conserved protein [Function unknown]; Region: COG1739 991791007199 Uncharacterized protein family UPF0029; Region: UPF0029; pfam01205 991791007200 Domain of unknown function (DUF1949); Region: DUF1949; pfam09186 991791007201 Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain (MocR family) and their eukaryotic orthologs [Transcription / Amino acid transport and metabolism]; Region: ARO8; COG1167 991791007202 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 991791007203 DNA-binding site [nucleotide binding]; DNA binding site 991791007204 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 991791007205 pyridoxal 5'-phosphate binding site [chemical binding]; other site 991791007206 homodimer interface [polypeptide binding]; other site 991791007207 catalytic residue [active] 991791007208 Nucleotidyltransferase (NT) domain of Staphylococcus aureus kanamycin nucleotidyltransferase, and similar proteins; Region: NT_KNTase_like; cd05403 991791007209 active site 991791007210 NTP binding site [chemical binding]; other site 991791007211 metal binding triad [ion binding]; metal-binding site 991791007212 antibiotic binding site [chemical binding]; other site 991791007213 GTP-binding protein HflX; Region: GTP_HflX; TIGR03156 991791007214 GTP-binding GTPase N-terminal; Region: GTP-bdg_N; pfam13167 991791007215 HflX GTPase family; Region: HflX; cd01878 991791007216 G1 box; other site 991791007217 GTP/Mg2+ binding site [chemical binding]; other site 991791007218 Switch I region; other site 991791007219 G2 box; other site 991791007220 G3 box; other site 991791007221 Switch II region; other site 991791007222 G4 box; other site 991791007223 G5 box; other site 991791007224 sporulation protein YunB; Region: spo_yunB; TIGR02832 991791007225 Transglycosylase; Region: Transgly; pfam00912 991791007226 penicillin-binding protein, 1A family; Region: PBP_1a_fam; TIGR02074 991791007227 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; cl17760 991791007228 Stage V sporulation protein AE1; Region: SpoVAE; pfam14097 991791007229 stage V sporulation protein AE; Region: spore_V_AE; TIGR02839 991791007230 stage V sporulation protein AD; Validated; Region: PRK08304 991791007231 stage V sporulation protein AD; Provisional; Region: PRK12404 991791007232 stage V sporulation protein AC; Region: spore_V_AC; TIGR02838 991791007233 sporulation sigma factor SigF; Validated; Region: PRK05572 991791007234 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 991791007235 Sigma-70 region 3; Region: Sigma70_r3; pfam04539 991791007236 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 991791007237 DNA binding residues [nucleotide binding] 991791007238 Histidine kinase-like ATPase domain; Region: HATPase_c_2; pfam13581 991791007239 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 991791007240 ATP binding site [chemical binding]; other site 991791007241 Mg2+ binding site [ion binding]; other site 991791007242 G-X-G motif; other site 991791007243 Sulphate Transporter and Anti-Sigma factor antagonist) domain of anti-anti-sigma factors, key regulators of anti-sigma factors by phosphorylation; Region: STAS_anti-anti-sigma_factors; cd07043 991791007244 Sulfate permease and related transporters (MFS superfamily) [Inorganic ion transport and metabolism]; Region: SUL1; COG0659 991791007245 anti sigma factor interaction site; other site 991791007246 regulatory phosphorylation site [posttranslational modification]; other site 991791007247 Type II restriction enzyme, methylase subunits [Defense mechanisms]; Region: COG1002 991791007248 Methyltransferase domain; Region: Methyltransf_26; pfam13659 991791007249 TaqI-like C-terminal specificity domain; Region: TaqI_C; pfam12950 991791007250 Methenyl tetrahydrofolate cyclohydrolase [Amino acid transport and metabolism]; Region: COG3404 991791007251 Nitroreductase-like family 3. A subfamily of the nitroreductase family containing uncharacterized proteins that are similar to nitroreductase. Nitroreductase catalyzes the reduction of nitroaromatic compounds such as nitrotoluenes, nitrofurans and...; Region: Nitroreductase_3; cd02139 991791007252 putative FMN binding site [chemical binding]; other site 991791007253 Glycosyltransferase like family 2; Region: Glyco_tranf_2_3; pfam13641 991791007254 Subfamily of Glycosyltransferase Family GT2 of unknown function; Region: GT_2_like_c; cd04186 991791007255 Probable Catalytic site; other site 991791007256 metal-binding site 991791007257 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 991791007258 Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013 991791007259 Membrane protein involved in the export of O-antigen and teichoic acid [General function prediction only]; Region: RfbX; COG2244 991791007260 Wzx, a subfamily of the multidrug and toxic compound extrusion (MATE)-like proteins; Region: MATE_Wzx_like; cd13128 991791007261 dTDP-6-deoxy-L-lyxo-4-hexulose reductase and related proteins, extended (e) SDRs; Region: dTDP_HR_like_SDR_e; cd05254 991791007262 RmlD substrate binding domain; Region: RmlD_sub_bind; pfam04321 991791007263 NADP binding site [chemical binding]; other site 991791007264 active site 991791007265 putative substrate binding site [chemical binding]; other site 991791007266 Predicted xylanase/chitin deacetylase [Carbohydrate transport and metabolism]; Region: CDA1; COG0726 991791007267 Putative catalytic NodB homology domain of PgaB, IcaB, and similar proteins which consist of a deformed (beta/alpha)8 barrel fold with 5- or 6-strands; Region: CE4_NodB_like_5s_6s; cd10918 991791007268 putative active site [active] 991791007269 putative metal binding site [ion binding]; other site 991791007270 Teichoic acid biosynthesis proteins [Cell envelope biogenesis, outer membrane]; Region: WecG; COG1922 991791007271 The glycosyltransferase WecG/TagA superfamily contains Escherichia coli WecG, Bacillus subtilis TagA and related proteins. E. coli WecG is believed to be a UDP-N-acetyl-D-mannosaminuronic acid transferase, and is involved in enterobacterial common...; Region: Glyco_transf_WecG_TagA; cd06533 991791007272 Lipid A core - O-antigen ligase and related enzymes [Cell envelope biogenesis, outer membrane]; Region: RfaL; COG3307 991791007273 O-Antigen ligase; Region: Wzy_C; pfam04932 991791007274 Predicted glycosyltransferases [General function prediction only]; Region: COG1216 991791007275 Subfamily of Glycosyltransferase Family GT2 of unknown function; Region: GT_2_like_c; cd04186 991791007276 Probable Catalytic site; other site 991791007277 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394 991791007278 Glycosyltransferase like family 2; Region: Glyco_tranf_2_3; pfam13641 991791007279 Subfamily of Glycosyltransferase Family GT2 of unknown function; Region: GT_2_like_c; cd04186 991791007280 Probable Catalytic site; other site 991791007281 metal-binding site 991791007282 glycosyltransferase, TIGR04182 family; Region: glyco_TIGR04182 991791007283 DPM_DPG-synthase_like is a member of the Glycosyltransferase 2 superfamily; Region: DPM_DPG-synthase_like; cd04179 991791007284 Ligand binding site; other site 991791007285 Putative Catalytic site; other site 991791007286 DXD motif; other site 991791007287 Bacterial surface proteins containing Ig-like domains [Cell motility and secretion]; Region: COG5492 991791007288 Clostridial hydrophobic, with a conserved W residue, domain; Region: ChW; smart00728 991791007289 Clostridial hydrophobic, with a conserved W residue, domain; Region: ChW; smart00728 991791007290 Clostridial hydrophobic, with a conserved W residue, domain; Region: ChW; smart00728 991791007291 Clostridial hydrophobic, with a conserved W residue, domain; Region: ChW; smart00728 991791007292 Clostridial hydrophobic, with a conserved W residue, domain; Region: ChW; smart00728 991791007293 Clostridial hydrophobic, with a conserved W residue, domain; Region: ChW; smart00728 991791007294 Bacterial Ig-like domain (group 3); Region: Big_3_4; pfam13754 991791007295 Beta- N-acetylglucosaminidase [Carbohydrate transport and metabolism]; Region: LytD; COG4193 991791007296 Lysozyme subfamily 2; Region: LYZ2; smart00047 991791007297 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 991791007298 Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013 991791007299 Predicted glycosyltransferases [General function prediction only]; Region: COG1216 991791007300 Subfamily of Glycosyltransferase Family GT2 of unknown function; Region: GT_2_like_c; cd04186 991791007301 Probable Catalytic site; other site 991791007302 metal-binding site 991791007303 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 991791007304 Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013 991791007305 ABC-type polysaccharide/polyol phosphate transport system, ATPase component [Carbohydrate transport and metabolism / Cell envelope biogenesis, outer membrane]; Region: TagH; COG1134 991791007306 ATP-binding cassette component of polysaccharide transport system; Region: ABC_KpsT_Wzt; cd03220 991791007307 Walker A/P-loop; other site 991791007308 ATP binding site [chemical binding]; other site 991791007309 Q-loop/lid; other site 991791007310 ABC transporter signature motif; other site 991791007311 Walker B; other site 991791007312 D-loop; other site 991791007313 H-loop/switch region; other site 991791007314 C-Terminal domain of O-antigenic polysaccharide transporter protein Wzt and related proteins; Region: Wzt_C-like; cd10147 991791007315 putative carbohydrate binding site [chemical binding]; other site 991791007316 ABC-type polysaccharide/polyol phosphate export systems, permease component [Carbohydrate transport and metabolism / Cell envelope biogenesis, outer membrane]; Region: TagG; COG1682 991791007317 ABC-2 type transporter; Region: ABC2_membrane; pfam01061 991791007318 exopolysaccharide biosynthesis polyprenyl glycosylphosphotransferase; Region: EPS_sugtrans; TIGR03025 991791007319 Sugar transferases involved in lipopolysaccharide synthesis [Cell envelope biogenesis, outer membrane]; Region: WcaJ; COG2148 991791007320 dTDP-4-dehydrorhamnose 3,5-epimerase; Region: dTDP_sugar_isom; pfam00908 991791007321 dTDP-D-glucose 4,6-dehydratase [Cell envelope biogenesis, outer membrane]; Region: RfbB; COG1088 991791007322 dTDP-D-glucose 4,6-dehydratase, extended (e) SDRs; Region: dTDP_GD_SDR_e; cd05246 991791007323 NAD binding site [chemical binding]; other site 991791007324 substrate binding site [chemical binding]; other site 991791007325 homodimer interface [polypeptide binding]; other site 991791007326 active site 991791007327 G1P_TT_short is the short form of glucose-1-phosphate thymidylyltransferase; Region: G1P_TT_short; cd02538 991791007328 glucose-1-phosphate thymidylyltransferase, short form; Region: rmlA; TIGR01207 991791007329 substrate binding site; other site 991791007330 tetramer interface; other site 991791007331 Nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: WcaG; COG0451 991791007332 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 991791007333 NAD(P) binding site [chemical binding]; other site 991791007334 active site 991791007335 Prokaryotic UGPase catalyses the synthesis of UDP-glucose; Region: UGPase_prokaryotic; cd02541 991791007336 dTDP-glucose pyrophosphorylase [Cell envelope biogenesis, outer membrane]; Region: RfbA; COG1209 991791007337 active site 991791007338 tetramer interface; other site 991791007339 Tetratricopeptide repeat; Region: TPR_12; pfam13424 991791007340 Tetratricopeptide repeat; Region: TPR_12; pfam13424 991791007341 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 991791007342 binding surface 991791007343 TPR motif; other site 991791007344 phosphoglucomutase-2-like protein; Provisional; Region: PTZ00150 991791007345 This CD includes PGM2 (phosphoglucomutase 2) and PGM2L1 (phosphoglucomutase 2-like 1). The mammalian PGM2 is thought to be a phosphopentomutase that catalyzes the conversion of the nucleoside breakdown products, ribose-1-phosphate and...; Region: PGM2; cd05799 991791007346 active site 991791007347 substrate binding site [chemical binding]; other site 991791007348 metal binding site [ion binding]; metal-binding site 991791007349 Arginine/lysine/ornithine decarboxylases [Amino acid transport and metabolism]; Region: LdcC; COG1982 991791007350 Ornithine decarboxylase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD corresponds to ornithine decarboxylase (ODC), arginine decarboxylase (ADC) and lysine...; Region: Orn_deC_like; cd00615 991791007351 homodimer interface [polypeptide binding]; other site 991791007352 pyridoxal 5'-phosphate binding site [chemical binding]; other site 991791007353 catalytic residue [active] 991791007354 Orn/Lys/Arg decarboxylase, C-terminal domain; Region: OKR_DC_1_C; pfam03711 991791007355 Uncharacterized conserved protein [Function unknown]; Region: COG1683 991791007356 recombination and DNA strand exchange inhibitor protein; Reviewed; Region: PRK00409 991791007357 MutS domain III; Region: MutS_III; pfam05192 991791007358 ATP-binding cassette domain of MutS2; Region: ABC_MutS2; cd03280 991791007359 Walker A/P-loop; other site 991791007360 ATP binding site [chemical binding]; other site 991791007361 Q-loop/lid; other site 991791007362 ABC transporter signature motif; other site 991791007363 Walker B; other site 991791007364 D-loop; other site 991791007365 H-loop/switch region; other site 991791007366 Smr domain; Region: Smr; pfam01713 991791007367 Collagenase and related proteases [Posttranslational modification, protein turnover, chaperones]; Region: COG0826 991791007368 Peptidase domain in the S8 and S53 families; Region: Peptidases_S8_S53; cl10459 991791007369 Peptidase family U32; Region: Peptidase_U32; pfam01136 991791007370 Collagenase; Region: DUF3656; pfam12392 991791007371 Peptidase family U32; Region: Peptidase_U32; cl03113 991791007372 Acetyltransferase (isoleucine patch superfamily) [General function prediction only]; Region: WbbJ; COG0110 991791007373 Maltose O-acyltransferase (MAT)-like: This family is composed of maltose O-acetyltransferase, galactoside O-acetyltransferase (GAT), xenobiotic acyltransferase (XAT) and similar proteins. MAT and GAT catalyze the CoA-dependent acetylation of the...; Region: LbH_MAT_like; cd04647 991791007374 trimer interface [polypeptide binding]; other site 991791007375 active site 991791007376 substrate binding site [chemical binding]; other site 991791007377 CoA binding site [chemical binding]; other site 991791007378 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 991791007379 Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013 991791007380 Glycosyltransferases involved in cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WcaA; COG0463 991791007381 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394 991791007382 active site 991791007383 Glycosyltransferase like family 2; Region: Glyco_tranf_2_3; pfam13641 991791007384 Glycosyl transferase family 2; Region: Glycos_transf_2; pfam00535 991791007385 active site 991791007386 Glycosyltransferase like family 2; Region: Glyco_tranf_2_3; pfam13641 991791007387 Subfamily of Glycosyltransferase Family GT2 of unknown function; Region: GT_2_like_c; cd04186 991791007388 Probable Catalytic site; other site 991791007389 metal-binding site 991791007390 Glycosyltransferases involved in cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WcaA; COG0463 991791007391 Glycosyl transferase family 2; Region: Glycos_transf_2; pfam00535 991791007392 active site 991791007393 Predicted pyridoxal phosphate-dependent enzyme apparently involved in regulation of cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WecE; COG0399 991791007394 3-amino-5-hydroxybenzoic acid synthase family (AHBA_syn). AHBA_syn family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The members of this CD are involved in various biosynthetic pathways for secondary...; Region: AHBA_syn; cd00616 991791007395 inhibitor-cofactor binding pocket; inhibition site 991791007396 pyridoxal 5'-phosphate binding site [chemical binding]; other site 991791007397 catalytic residue [active] 991791007398 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394 991791007399 Protein of unknown function (DUF3343); Region: DUF3343; pfam11823 991791007400 Selenocysteine lyase/Cysteine desulfurase [Posttranslational modification, protein turnover, chaperones]; Region: csdA; COG0520 991791007401 Cysteine desulfurase (SufS)-like. This family belongs to the pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to cysteine desulfurase (SufS) and selenocysteine lyase. SufS...; Region: SufS_like; cd06453 991791007402 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 991791007403 catalytic residue [active] 991791007404 Cell division protein ZapA (stimulator of FtsZ polymerization and Z-ring component) [Cell cycle control, cell division, chromosome partitioning]; Region: zapA; COG3027 991791007405 phenylalanyl-tRNA synthetase subunit beta; Reviewed; Region: pheT; PRK00629 991791007406 tRNA-binding-domain-containing prokaryotic phenylalanly tRNA synthetase (PheRS) beta chain. PheRS aminoacylate phenylalanine transfer RNAs (tRNAphe). PheRSs belong structurally to class II aminoacyl tRNA synthetases (aaRSs) but, as they aminoacylate...; Region: tRNA_bind_bactPheRS; cd02796 991791007407 putative tRNA-binding site [nucleotide binding]; other site 991791007408 B3/4 domain; Region: B3_4; pfam03483 991791007409 tRNA synthetase B5 domain; Region: B5; smart00874 991791007410 Phenylalanyl-tRNA synthetase (PheRS) beta chain core domain. PheRS belongs to class II aminoacyl-tRNA synthetases (aaRS) based upon its structure. While class II aaRSs generally aminoacylate the 3'-OH ribose of the appropriate tRNA, PheRS is an...; Region: PheRS_beta_core; cd00769 991791007411 dimer interface [polypeptide binding]; other site 991791007412 motif 1; other site 991791007413 motif 3; other site 991791007414 motif 2; other site 991791007415 Ferredoxin-fold anticodon binding domain; Region: FDX-ACB; pfam03147 991791007416 phenylalanyl-tRNA synthetase subunit alpha; Validated; Region: pheS; PRK00488 991791007417 Aminoacyl tRNA synthetase class II, N-terminal domain; Region: Phe_tRNA-synt_N; pfam02912 991791007418 Phenylalanyl-tRNA synthetase (PheRS) alpha chain catalytic core domain. PheRS belongs to class II aminoacyl-tRNA synthetases (aaRS) based upon its structure and the presence of three characteristic sequence motifs. This domain is primarily responsible...; Region: PheRS_alpha_core; cd00496 991791007419 dimer interface [polypeptide binding]; other site 991791007420 motif 1; other site 991791007421 active site 991791007422 motif 2; other site 991791007423 motif 3; other site 991791007424 rRNA methylases [Translation, ribosomal structure and biogenesis]; Region: SpoU; COG0566 991791007425 RNA 2'-O ribose methyltransferase substrate binding; Region: SpoU_sub_bind; smart00967 991791007426 SpoU rRNA Methylase family; Region: SpoU_methylase; pfam00588 991791007427 Ribosomal protein L20; Region: Ribosomal_L20; cd07026 991791007428 23S rRNA binding site [nucleotide binding]; other site 991791007429 L21 binding site [polypeptide binding]; other site 991791007430 L13 binding site [polypeptide binding]; other site 991791007431 50S ribosomal protein L35; Reviewed; Region: rpmI; PRK00172 991791007432 Translation initiation factor 3 (IF-3) [Translation, ribosomal structure and biogenesis]; Region: InfC; COG0290 991791007433 Translation initiation factor IF-3, N-terminal domain; Region: IF3_N; pfam05198 991791007434 Translation initiation factor IF-3, C-terminal domain; Region: IF3_C; pfam00707 991791007435 threonyl-tRNA synthetase; Reviewed; Region: thrS; PRK00413 991791007436 TGS _ThrRS_N: ThrRS (threonyl-tRNA Synthetase) is a class II tRNA synthetase that couples threonine to its cognate tRNA. In addition to its catalytic and anticodon-binding domains, ThrRS has an N-terminal TGS domain, named after the ThrRS, GTPase, and...; Region: TGS_ThrRS_N; cd01667 991791007437 Threonyl and Alanyl tRNA synthetase second additional domain; Region: tRNA_SAD; smart00863 991791007438 Threonyl-tRNA synthetase (ThrRS) class II core catalytic domain. ThrRS is a homodimer. It is responsible for the attachment of threonine to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for ATP-dependent...; Region: ThrRS_core; cd00771 991791007439 active site 991791007440 dimer interface [polypeptide binding]; other site 991791007441 motif 1; other site 991791007442 motif 2; other site 991791007443 motif 3; other site 991791007444 ThrRS Threonyl-anticodon binding domain. ThrRS belongs to class II aminoacyl-tRNA synthetases (aaRS). This alignment contains the anticodon binding domain, which is responsible for specificity in tRNA-binding, so that the activated amino acid is...; Region: ThrRS_anticodon; cd00860 991791007445 anticodon binding site; other site 991791007446 putative sporulation protein YtxC; Region: spo_ytxC; TIGR02834 991791007447 Small, acid-soluble spore proteins, alpha/beta type; Region: SASP; pfam00269 991791007448 Clostridial hydrophobic, with a conserved W residue, domain; Region: ChW; smart00728 991791007449 Bacterial surface proteins containing Ig-like domains [Cell motility and secretion]; Region: COG5492 991791007450 Clostridial hydrophobic, with a conserved W residue, domain; Region: ChW; smart00728 991791007451 Clostridial hydrophobic, with a conserved W residue, domain; Region: ChW; smart00728 991791007452 Bacterial Ig-like domain (group 2); Region: Big_2; pfam02368 991791007453 Bacterial surface proteins containing Ig-like domains [Cell motility and secretion]; Region: COG5492 991791007454 Clostridial hydrophobic, with a conserved W residue, domain; Region: ChW; smart00728 991791007455 Clostridial hydrophobic, with a conserved W residue, domain; Region: ChW; smart00728 991791007456 Clostridial hydrophobic, with a conserved W residue, domain; Region: ChW; smart00728 991791007457 Clostridial hydrophobic, with a conserved W residue, domain; Region: ChW; smart00728 991791007458 Clostridial hydrophobic, with a conserved W residue, domain; Region: ChW; smart00728 991791007459 Clostridial hydrophobic, with a conserved W residue, domain; Region: ChW; smart00728 991791007460 Transglutaminase-like superfamily; Region: Transglut_core; cl17362 991791007461 Hsp33-like chaperonin; Reviewed; Region: hslO; PRK00114 991791007462 Heat shock protein 33 (Hsp33): Cytosolic protein that acts as a molecular chaperone under oxidative conditions. In normal (reducing) cytosolic conditions, four conserved Cys residues are coordinated by a Zn ion. Under oxidative stress (such as heat...; Region: Hsp33; cd00498 991791007463 dimerization interface [polypeptide binding]; other site 991791007464 domain crossover interface; other site 991791007465 redox-dependent activation switch; other site 991791007466 Methyltransferase domain; Region: Methyltransf_31; pfam13847 991791007467 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 991791007468 S-adenosylmethionine binding site [chemical binding]; other site 991791007469 Small, acid-soluble spore proteins, alpha/beta type; Region: SASP; pfam00269 991791007470 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppC; COG1173 991791007471 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 991791007472 dimer interface [polypeptide binding]; other site 991791007473 conserved gate region; other site 991791007474 putative PBP binding loops; other site 991791007475 ABC-ATPase subunit interface; other site 991791007476 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppB; COG0601 991791007477 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 991791007478 dimer interface [polypeptide binding]; other site 991791007479 conserved gate region; other site 991791007480 putative PBP binding loops; other site 991791007481 ABC-ATPase subunit interface; other site 991791007482 The substrate-binding domain of an ABC-type nickel/oligopeptide-like import system contains the type 2 periplasmic binding fold; Region: PBP2_NikA_DppA_OppA_like; cl01709 991791007483 ABC-type dipeptide transport system, periplasmic component [Amino acid transport and metabolism]; Region: DdpA; COG0747 991791007484 Dihydrodipicolinate synthase/N-acetylneuraminate lyase [Amino acid transport and metabolism / Cell envelope biogenesis, outer membrane]; Region: DapA; COG0329 991791007485 Dihydrodipicolinate synthase (DHDPS); Region: DHDPS; cd00950 991791007486 dimer interface [polypeptide binding]; other site 991791007487 active site 991791007488 catalytic residue [active] 991791007489 Dihydrodipicolinate reductase [Amino acid transport and metabolism]; Region: DapB; COG0289 991791007490 Dihydrodipicolinate reductase, N-terminus; Region: DapB_N; pfam01113 991791007491 Dihydrodipicolinate reductase, C-terminus; Region: DapB_C; pfam05173 991791007492 aminotransferase A; Validated; Region: PRK07683 991791007493 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 991791007494 pyridoxal 5'-phosphate binding site [chemical binding]; other site 991791007495 homodimer interface [polypeptide binding]; other site 991791007496 catalytic residue [active] 991791007497 Tetrahydrodipicolinate succinyltransferase N-terminal; Region: DapH_N; pfam08503 991791007498 2,3,4,5-tetrahydropyridine-2,6-dicarboxylate N-acetyltransferase; Region: DapD_Ac; TIGR03532 991791007499 2,3,4,5-tetrahydropyridine-2,6-dicarboxylate (THDP) N-succinyltransferase (also called THP succinyltransferase): THDP N-succinyltransferase catalyzes the conversion of tetrahydrodipicolinate and succinyl-CoA to N-succinyltetrahydrodipicolinate and CoA; Region: LbH_THP_succinylT; cd03350 991791007500 active site 991791007501 trimer interface [polypeptide binding]; other site 991791007502 substrate binding site [chemical binding]; other site 991791007503 CoA binding site [chemical binding]; other site 991791007504 single-stranded DNA-binding protein; Provisional; Region: PRK05813 991791007505 SSB_OBF: A subfamily of OB folds similar to the OB fold of ssDNA-binding protein (SSB). SSBs bind with high affinity to ssDNA. They bind to and protect ssDNA intermediates during DNA metabolic pathways. All bacterial and eukaryotic SSBs studied to date...; Region: SSB_OBF; cd04496 991791007506 dimer interface [polypeptide binding]; other site 991791007507 ssDNA binding site [nucleotide binding]; other site 991791007508 tetramer (dimer of dimers) interface [polypeptide binding]; other site 991791007509 Predicted xylanase/chitin deacetylase [Carbohydrate transport and metabolism]; Region: CDA1; COG0726 991791007510 Catalytic NodB homology domain of rhizobial NodB-like proteins; Region: CE4_NodB_like_6s_7s; cd10917 991791007511 NodB motif; other site 991791007512 active site 991791007513 catalytic site [active] 991791007514 metal binding site [ion binding]; metal-binding site 991791007515 Domain of unknown function (DUF4364); Region: DUF4364; pfam14277 991791007516 Uncharacterized conserved protein [Function unknown]; Region: COG3391 991791007517 TSCPD domain; Region: TSCPD; cl14834 991791007518 acetylornithine aminotransferase; Provisional; Region: PRK02627 991791007519 Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610 991791007520 inhibitor-cofactor binding pocket; inhibition site 991791007521 pyridoxal 5'-phosphate binding site [chemical binding]; other site 991791007522 catalytic residue [active] 991791007523 AAK_NAGK-C: N-Acetyl-L-glutamate kinase - cyclic (NAGK-C) catalyzes the phosphorylation of the gamma-COOH group of N-acetyl-L-glutamate (NAG) by ATP in the second step of arginine biosynthesis found in some bacteria and photosynthetic organisms using the...; Region: AAK_NAGK-C; cd04250 991791007524 homohexameric interface [polypeptide binding]; other site 991791007525 feedback inhibition sensing region; other site 991791007526 nucleotide binding site [chemical binding]; other site 991791007527 N-acetyl-L-glutamate binding site [chemical binding]; other site 991791007528 N-acetyl-gamma-glutamyl-phosphate reductase; Validated; Region: argC; PRK00436 991791007529 Semialdehyde dehydrogenase, NAD binding domain; Region: Semialdhyde_dh; smart00859 991791007530 Ornithine acetyltransferase (OAT) family; also referred to as ArgJ. OAT catalyzes the first and fifth steps in arginine biosynthesis, coupling acetylation of glutamate with deacetylation of N-acetylornithine, which allows recycling of the acetyl group in...; Region: OAT; cd02152 991791007531 heterotetramer interface [polypeptide binding]; other site 991791007532 active site pocket [active] 991791007533 cleavage site 991791007534 ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132 991791007535 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 991791007536 ATP-binding cassette domain of glucan transporter and related proteins, subfamily C; Region: ABCC_Glucan_exporter_like; cd03254 991791007537 Walker A/P-loop; other site 991791007538 ATP binding site [chemical binding]; other site 991791007539 Q-loop/lid; other site 991791007540 ABC transporter signature motif; other site 991791007541 Walker B; other site 991791007542 D-loop; other site 991791007543 H-loop/switch region; other site 991791007544 ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132 991791007545 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 991791007546 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 991791007547 Walker A/P-loop; other site 991791007548 ATP binding site [chemical binding]; other site 991791007549 Q-loop/lid; other site 991791007550 ABC transporter signature motif; other site 991791007551 Walker B; other site 991791007552 D-loop; other site 991791007553 H-loop/switch region; other site 991791007554 Transcriptional regulator [Transcription]; Region: LysR; COG0583 991791007555 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 991791007556 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cd05466 991791007557 dimerization interface [polypeptide binding]; other site 991791007558 Membrane-associated phospholipid phosphatase [Lipid metabolism]; Region: PgpB; COG0671 991791007559 PAP2_like proteins, BcrC_like subfamily. Several members of this family have been annotated as bacitracin transport permeases, as it was suspected that they form the permease component of an ABC transporter system. It was shown, however, that BcrC from...; Region: PAP2_BcrC_like; cd03385 991791007560 active site 991791007561 Predicted xylanase/chitin deacetylase [Carbohydrate transport and metabolism]; Region: CDA1; COG0726 991791007562 Catalytic NodB homology domain of Streptococcus mutans polysaccharide deacetylase PgdA, Bacillus subtilis YheN, and similar proteins; Region: CE4_SmPgdA_like; cd10944 991791007563 NodB motif; other site 991791007564 active site 991791007565 catalytic site [active] 991791007566 Zn binding site [ion binding]; other site 991791007567 S1_like: Ribosomal protein S1-like RNA-binding domain. Found in a wide variety of RNA-associated proteins. Originally identified in S1 ribosomal protein. This superfamily also contains the Cold Shock Domain (CSD), which is a homolog of the S1 domain; Region: S1_like; cl09927 991791007568 Folylpolyglutamate synthase [Coenzyme metabolism]; Region: FolC; COG0285 991791007569 Mur ligase middle domain; Region: Mur_ligase_M; pfam08245 991791007570 Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875 991791007571 valyl-tRNA synthetase; Reviewed; Region: valS; PRK05729 991791007572 nucleotidyl transferase superfamily; Region: nt_trans; cl00015 991791007573 active site 991791007574 HIGH motif; other site 991791007575 nucleotide binding site [chemical binding]; other site 991791007576 Leucyl-tRNA synthetase, Domain 2; Region: tRNA-synt_1_2; pfam13603 991791007577 catalytic core domain of valyl-tRNA synthetases; Region: ValRS_core; cd00817 991791007578 active site 991791007579 KMSKS motif; other site 991791007580 Anticodon-binding domain of valyl tRNA synthetases; Region: Anticodon_Ia_Val; cd07962 991791007581 tRNA binding surface [nucleotide binding]; other site 991791007582 anticodon binding site; other site 991791007583 Valyl tRNA synthetase tRNA binding arm; Region: Val_tRNA-synt_C; pfam10458 991791007584 Protein Kinases, catalytic domain; Region: PKc_like; cl09925 991791007585 active site 991791007586 ATP binding site [chemical binding]; other site 991791007587 BadF/BadG/BcrA/BcrD ATPase family; Region: BcrAD_BadFG; cl17271 991791007588 Activator of 2-hydroxyglutaryl-CoA dehydratase (HSP70-class ATPase domain) [Lipid metabolism]; Region: COG1924 991791007589 BadF/BadG/BcrA/BcrD ATPase family; Region: BcrAD_BadFG; cl17271 991791007590 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3580 991791007591 2-hydroxyglutaryl-CoA dehydratase, D-component; Region: HGD-D; pfam06050 991791007592 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3581 991791007593 Tetratricopeptide repeat; Region: TPR_12; pfam13424 991791007594 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 991791007595 binding surface 991791007596 TPR motif; other site 991791007597 TPR repeat; Region: TPR_11; pfam13414 991791007598 Carbohydrate Binding Module 6 (CBM6) and CBM35_like superfamily; Region: CBM6-CBM35-CBM36_like; cl14880 991791007599 Glycosyltransferases involved in cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WcaA; COG0463 991791007600 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cd00761 991791007601 active site 991791007602 This family is most closely related to the GT1 family of glycosyltransferases and named after YqgM in Bacillus licheniformis about which little is known. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to...; Region: GT1_YqgM_like; cd03801 991791007603 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 991791007604 Multidrug and toxic compound extrusion family and similar proteins; Region: MATE_like; cl09326 991791007605 Membrane protein involved in the export of O-antigen and teichoic acid [General function prediction only]; Region: RfbX; COG2244 991791007606 Response regulator receiver domain; Region: Response_reg; pfam00072 991791007607 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 991791007608 active site 991791007609 phosphorylation site [posttranslational modification] 991791007610 intermolecular recognition site; other site 991791007611 dimerization interface [polypeptide binding]; other site 991791007612 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394 991791007613 active site 991791007614 Transglutaminase-like enzymes, putative cysteine proteases [Amino acid transport and metabolism]; Region: COG1305 991791007615 Transglutaminase-like superfamily; Region: Transglut_core; pfam01841 991791007616 RecX family; Region: RecX; cl00936 991791007617 Predicted Zn-dependent peptidases [General function prediction only]; Region: PqqL; COG0612 991791007618 Insulinase (Peptidase family M16); Region: Peptidase_M16; pfam00675 991791007619 Peptidase M16 inactive domain; Region: Peptidase_M16_C; pfam05193 991791007620 Uncharacterized conserved protein [Function unknown]; Region: COG4127 991791007621 Predicted membrane protein [Function unknown]; Region: COG4708 991791007622 Uncharacterized conserved protein [Function unknown]; Region: COG1543 991791007623 N-terminal catalytic domain of alpha-amylase ( AmyC ) and similar proteins; Region: GH57N_AmyC_like; cd10792 991791007624 active site 991791007625 substrate binding site [chemical binding]; other site 991791007626 catalytic site [active] 991791007627 Domain of unknown function (DUF1957); Region: DUF1957; pfam09210 991791007628 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3330 991791007629 Uncharacterized protein conserved in bacteria [Function unknown]; Region: ErfK; COG1376 991791007630 L,D-transpeptidase catalytic domain; Region: YkuD; pfam03734 991791007631 Putative peptidoglycan binding domain; Region: PG_binding_1; pfam01471 991791007632 Cache domain; Region: Cache_1; pfam02743 991791007633 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 991791007634 dimerization interface [polypeptide binding]; other site 991791007635 Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer); Region: MA; smart00283 991791007636 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 991791007637 dimer interface [polypeptide binding]; other site 991791007638 putative CheW interface [polypeptide binding]; other site 991791007639 Elongator protein 3, MiaB family, Radical SAM; Region: Elp3; smart00729 991791007640 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 991791007641 FeS/SAM binding site; other site 991791007642 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 991791007643 haloacid dehalogenase-like hydrolase; Region: Hydrolase_3; pfam08282 991791007644 active site 991791007645 motif I; other site 991791007646 motif II; other site 991791007647 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cl17915 991791007648 Predicted esterase of the alpha-beta hydrolase superfamily [General function prediction only]; Region: COG4667 991791007649 Hypothetical patatin similar to yjju protein of Escherichia coli; Region: Pat_hypo_Ecoli_yjju_like; cd07208 991791007650 active site 991791007651 nucleophile elbow; other site 991791007652 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3580 991791007653 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3581 991791007654 Activator of 2-hydroxyglutaryl-CoA dehydratase (HSP70-class ATPase domain) [Lipid metabolism]; Region: COG1924 991791007655 BadF/BadG/BcrA/BcrD ATPase family; Region: BcrAD_BadFG; cl17271 991791007656 PilZ domain; Region: PilZ; pfam07238 991791007657 transcription elongation factor GreA; Region: greA; TIGR01462 991791007658 Transcription elongation factor, N-terminal; Region: GreA_GreB_N; pfam03449 991791007659 Transcription elongation factor, GreA/GreB, C-term; Region: GreA_GreB; pfam01272 991791007660 Phosphoglycerol transferase and related proteins, alkaline phosphatase superfamily [Cell envelope biogenesis, outer membrane]; Region: MdoB; COG1368 991791007661 Sulfatase; Region: Sulfatase; pfam00884 991791007662 Predicted permease, member of the PurR regulon [General function prediction only]; Region: yhhT; COG0628 991791007663 Trypsin-like peptidase domain; Region: Trypsin_2; pfam13365 991791007664 PDZ domain of tryspin-like serine proteases, such as DegP/HtrA, which are oligomeric proteins involved in heat-shock response, chaperone function, and apoptosis. May be responsible for substrate recognition and/or binding, as most PDZ domains bind...; Region: PDZ_serine_protease; cd00987 991791007665 protein binding site [polypeptide binding]; other site 991791007666 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 991791007667 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 991791007668 dimerization interface [polypeptide binding]; other site 991791007669 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 991791007670 dimer interface [polypeptide binding]; other site 991791007671 phosphorylation site [posttranslational modification] 991791007672 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 991791007673 ATP binding site [chemical binding]; other site 991791007674 Mg2+ binding site [ion binding]; other site 991791007675 G-X-G motif; other site 991791007676 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 991791007677 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 991791007678 active site 991791007679 phosphorylation site [posttranslational modification] 991791007680 intermolecular recognition site; other site 991791007681 dimerization interface [polypeptide binding]; other site 991791007682 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 991791007683 DNA binding site [nucleotide binding] 991791007684 Predicted multitransmembrane protein [Function unknown]; Region: COG5438 991791007685 Conserved protein/domain typically associated with flavoprotein oxygenases, DIM6/NTAB family [General function prediction only]; Region: COG1853 991791007686 PAP2_like proteins, a super-family of histidine phosphatases and vanadium haloperoxidases, includes type 2 phosphatidic acid phosphatase or lipid phosphate phosphatase (LPP), Glucose-6-phosphatase, Phosphatidylglycerophosphatase B and bacterial acid...; Region: PAP2_like; cl00474 991791007687 active site 991791007688 Copper amine oxidase N-terminal domain; Region: Cu_amine_oxidN1; pfam07833 991791007689 Periplasmic binding protein TroA_d. These proteins are predicted to function as initial receptors in the ABC metal ion uptake in eubacteria and archaea. They belong to the TroA superfamily of helical backbone metal receptor proteins that share a...; Region: TroA_d; cd01141 991791007690 putative ligand binding site [chemical binding]; other site 991791007691 ABC-type Fe3+-hydroxamate transport system, periplasmic component [Inorganic ion transport and metabolism]; Region: FepB; COG0614 991791007692 Helical backbone metal receptor (TroA-like domain). These proteins have been shown to function in the ABC transport of ferric siderophores and metal ions such as Mn2+, Fe3+, Cu2+ and/or Zn2+. Their ligand binding site is formed in the interface between...; Region: TroA-like; cl00262 991791007693 iron-hydroxamate transporter permease subunit; Provisional; Region: PRK10577 991791007694 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550 991791007695 ABC-ATPase subunit interface; other site 991791007696 dimer interface [polypeptide binding]; other site 991791007697 putative PBP binding regions; other site 991791007698 ABC-type cobalamin/Fe3+-siderophores transport systems, ATPase components [Inorganic ion transport and metabolism / Coenzyme metabolism]; Region: FepC; COG1120 991791007699 ATP-binding component of iron-siderophores, vitamin B12 and hemin transporters and related proteins; Region: ABC_Iron-Siderophores_B12_Hemin; cd03214 991791007700 Walker A/P-loop; other site 991791007701 ATP binding site [chemical binding]; other site 991791007702 Q-loop/lid; other site 991791007703 ABC transporter signature motif; other site 991791007704 Walker B; other site 991791007705 D-loop; other site 991791007706 H-loop/switch region; other site 991791007707 Uncharacterized protein containing a Zn-finger-like domain [General function prediction only]; Region: COG2158 991791007708 5-aminoimidazole-4-carboxamide ribonucleotide transformylase; Provisional; Region: PRK07106 991791007709 AICAR transformylase/IMP cyclohydrolase PurH (only IMP cyclohydrolase domain in Aful) [Nucleotide transport and metabolism]; Region: PurH; COG0138 991791007710 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox_2; pfam07992 991791007711 Uncharacterized flavoproteins [Energy production and conversion]; Region: FpaA; COG0426 991791007712 Metallo-beta-lactamase superfamily; Region: Lactamase_B; smart00849 991791007713 Flavodoxin-like fold; Region: Flavodoxin_2; cl00438 991791007714 Desulfoferrodoxin [Energy production and conversion]; Region: COG2033 991791007715 Superoxide reductase-like (SORL) domain; present in a family of mononuclear non-heme iron proteins that includes superoxide reductase and desulfoferrodoxin. Superoxide reductase-like proteins scavenge superoxide anion radicals as a defense mechanism...; Region: SORL; cd00524 991791007716 non-heme iron binding site [ion binding]; other site 991791007717 Predicted transcriptional regulators [Transcription]; Region: SoxR; COG0789 991791007718 Helix-Turn-Helix DNA binding domain of MerR-like transcription regulators; Region: HTH_MerR-like; cd00592 991791007719 DNA binding residues [nucleotide binding] 991791007720 Methyltransferase domain; Region: Methyltransf_23; pfam13489 991791007721 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 991791007722 S-adenosylmethionine binding site [chemical binding]; other site 991791007723 flavodoxin; Provisional; Region: PRK05569 991791007724 Uncharacterized flavoproteins [Energy production and conversion]; Region: FpaA; COG0426 991791007725 The CBS domain, named after human CBS, is a small domain originally identified in cystathionine beta-synthase and is subsequently found in a wide range of different proteins. CBS domains usually occur in tandem repeats. They associate to form a so-called...; Region: CBS_pair; cl15354 991791007726 2-oxoacid:acceptor oxidoreductase, beta subunit, pyruvate/2-ketoisovalerate family; Region: PorB_KorB; TIGR02177 991791007727 Thiamine pyrophosphate (TPP family), 2-oxoglutarate ferredoxin oxidoreductase (OGFOR) subfamily, TPP-binding module; OGFOR catalyzes the oxidative decarboxylation of 2-oxo-acids, with ferredoxin acting as an electron acceptor. In the TCA cycle, OGFOR...; Region: TPP_OGFOR; cd03375 991791007728 TPP-binding site [chemical binding]; other site 991791007729 Pyruvate ferredoxin oxidoreductase beta subunit C terminal; Region: PFO_beta_C; pfam12367 991791007730 Pyruvate:ferredoxin oxidoreductase and related 2-oxoacid:ferredoxin oxidoreductases, gamma subunit [Energy production and conversion]; Region: PorG; COG1014 991791007731 2-oxoacid:acceptor oxidoreductase, alpha subunit; Region: OAFO_sf; TIGR03710 991791007732 Pyrimidine (PYR) binding domain of pyruvate ferredoxin oxidoreductase (PFOR), indolepyruvate ferredoxin oxidoreductase alpha subunit (IOR-alpha), and related proteins; Region: TPP_PYR_PFOR_IOR-alpha_like; cd07034 991791007733 dimer interface [polypeptide binding]; other site 991791007734 PYR/PP interface [polypeptide binding]; other site 991791007735 TPP binding site [chemical binding]; other site 991791007736 substrate binding site [chemical binding]; other site 991791007737 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3220 991791007738 Bleomycin binding protein (BLMA) and similar proteins; BLMA confers bleomycin (Bm) resistance by directly binding to Bm; Region: BLMA_like; cd08349 991791007739 dimer interface [polypeptide binding]; other site 991791007740 ligand binding site [chemical binding]; other site 991791007741 Predicted secreted protein [Function unknown]; Region: COG5513 991791007742 Acetyltransferase (GNAT) domain; Region: Acetyltransf_10; pfam13673 991791007743 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 991791007744 Coenzyme A binding pocket [chemical binding]; other site 991791007745 This domain superfamily is found in a variety of structurally related metalloproteins, including the type I extradiol dioxygenases, glyoxalase I and a group of antibiotic resistance proteins; Region: Glo_EDI_BRP_like; cl14632 991791007746 Putative zinc ribbon domain; Region: Zn_ribbon_2; pfam12674 991791007747 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 991791007748 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 991791007749 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 991791007750 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 991791007751 non-specific DNA binding site [nucleotide binding]; other site 991791007752 salt bridge; other site 991791007753 sequence-specific DNA binding site [nucleotide binding]; other site 991791007754 Polypeptide or peptide deformylase; a family of metalloenzymes that catalyzes the removal of the N-terminal formyl group in a growing polypeptide chain following translation initiation during protein synthesis in prokaryotes. These enzymes utilize Fe(II)...; Region: Pep_deformylase; cd00487 991791007755 active site 991791007756 catalytic residues [active] 991791007757 metal binding site [ion binding]; metal-binding site 991791007758 Predicted flavin-nucleotide-binding protein [General function prediction only]; Region: COG3467 991791007759 Regulator of competence-specific genes [Transcription]; Region: TfoX; COG3070 991791007760 hypothetical protein; Provisional; Region: PRK11479 991791007761 CAAX protease self-immunity; Region: Abi; pfam02517 991791007762 Acetyltransferases, including N-acetylases of ribosomal proteins [Translation, ribosomal structure and biogenesis]; Region: RimL; COG1670 991791007763 Acetyltransferase (GNAT) family; Region: Acetyltransf_1; pfam00583 991791007764 Coenzyme A binding pocket [chemical binding]; other site 991791007765 topology modulation protein; Reviewed; Region: PRK08118 991791007766 AAA domain; Region: AAA_17; pfam13207 991791007767 Carbonic anhydrases (CA) are zinc-containing enzymes that catalyze the reversible hydration of carbon dioxide in a two-step mechanism in which the nucleophilic attack of a zinc-bound hydroxide ion on carbon dioxide is followed by the regeneration of an...; Region: beta_CA_cladeC; cd03378 991791007768 active site clefts [active] 991791007769 zinc binding site [ion binding]; other site 991791007770 dimer interface [polypeptide binding]; other site 991791007771 Methyl-accepting chemotaxis protein [Cell motility and secretion / Signal transduction mechanisms]; Region: Tar; COG0840 991791007772 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 991791007773 dimer interface [polypeptide binding]; other site 991791007774 putative CheW interface [polypeptide binding]; other site 991791007775 Predicted membrane protein [Function unknown]; Region: COG4129 991791007776 Bacterial protein of unknown function (DUF939); Region: DUF939; pfam06081 991791007777 DUF939 C-terminal domain; Region: DUF939_C; pfam11728 991791007778 Na+-driven multidrug efflux pump [Defense mechanisms]; Region: NorM; COG0534 991791007779 Subfamily of the multidrug and toxic compound extrusion (MATE)-like proteins similar to Streptococcus aureus MepA; Region: MATE_MepA_like; cd13143 991791007780 helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347 991791007781 MarR family; Region: MarR_2; pfam12802 991791007782 MarR family; Region: MarR_2; cl17246 991791007783 Acetyltransferase (GNAT) domain; Region: Acetyltransf_3; pfam13302 991791007784 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 991791007785 Coenzyme A binding pocket [chemical binding]; other site 991791007786 Hemerythrin-like domain; Region: Hr-like; cd12108 991791007787 Fe binding site [ion binding]; other site 991791007788 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 991791007789 non-specific DNA binding site [nucleotide binding]; other site 991791007790 salt bridge; other site 991791007791 sequence-specific DNA binding site [nucleotide binding]; other site 991791007792 Tetratricopeptide repeat; Region: TPR_12; pfam13424 991791007793 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 991791007794 binding surface 991791007795 TPR motif; other site 991791007796 Tetratricopeptide repeat; Region: TPR_12; pfam13424 991791007797 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 991791007798 Coenzyme A binding pocket [chemical binding]; other site 991791007799 Zinc dependent phospholipase C; Region: Zn_dep_PLPC; pfam00882 991791007800 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 991791007801 non-specific DNA binding site [nucleotide binding]; other site 991791007802 salt bridge; other site 991791007803 sequence-specific DNA binding site [nucleotide binding]; other site 991791007804 Predicted phosphatases [General function prediction only]; Region: Gph; COG0546 991791007805 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cl17915 991791007806 motif II; other site 991791007807 carbon-monoxide dehydrogenase, catalytic subunit; Region: CO_DH_cata; TIGR01702 991791007808 Carbon monoxide dehydrogenase (CODH) is found in acetogenic and methanogenic organisms and is responsible for the synthesis and breakdown of acetyl-CoA, respectively. CODH has two types of metal clusters, a cubane [Fe4-S4] center (B-cluster) similar to...; Region: CODH; cd01915 991791007809 ACS interaction site; other site 991791007810 CODH interaction site; other site 991791007811 cubane metal cluster (B-cluster) [ion binding]; other site 991791007812 Ni-Fe-S cluster (C-cluster) [ion binding]; other site 991791007813 pyruvate:ferredoxin (flavodoxin) oxidoreductase, homodimeric; Region: pyruv_ox_red; TIGR02176 991791007814 Pyrimidine (PYR) binding domain of pyruvate ferredoxin oxidoreductase (PFOR), indolepyruvate ferredoxin oxidoreductase alpha subunit (IOR-alpha), and related proteins; Region: TPP_PYR_PFOR_IOR-alpha_like; cd07034 991791007815 dimer interface [polypeptide binding]; other site 991791007816 PYR/PP interface [polypeptide binding]; other site 991791007817 TPP binding site [chemical binding]; other site 991791007818 substrate binding site [chemical binding]; other site 991791007819 Pyruvate:ferredoxin oxidoreductase and related 2-oxoacid:ferredoxin oxidoreductases, gamma subunit [Energy production and conversion]; Region: PorG; COG1014 991791007820 Domain of unknown function; Region: EKR; smart00890 991791007821 4Fe-4S binding domain; Region: Fer4_6; pfam12837 991791007822 4Fe-4S binding domain; Region: Fer4; pfam00037 991791007823 Thiamine pyrophosphate (TPP family), PFOR_PNO subfamily, TPP-binding module; composed of proteins similar to the single subunit pyruvate ferredoxin oxidoreductase (PFOR) of Desulfovibrio Africanus, present in bacteria and amitochondriate eukaryotes. This...; Region: TPP_PFOR_PNO; cd03377 991791007824 TPP-binding site [chemical binding]; other site 991791007825 dimer interface [polypeptide binding]; other site 991791007826 membrane protein; Provisional; Region: PRK14413 991791007827 4-amino-4-deoxy-L-arabinose-phosphoundecaprenol flippase subunit ArnE; Provisional; Region: PRK15051 991791007828 Domain of unknown function (DUF3787); Region: DUF3787; pfam12655 991791007829 Sporulation protein and related proteins [Cell division and chromosome partitioning]; Region: SpoIID; COG2385 991791007830 Stage II sporulation protein; Region: SpoIID; pfam08486 991791007831 triple tyrosine motif-containing protein; Provisional; Region: PRK14081 991791007832 Y_Y_Y domain; Region: Y_Y_Y; pfam07495 991791007833 Y_Y_Y domain; Region: Y_Y_Y; pfam07495 991791007834 Y_Y_Y domain; Region: Y_Y_Y; pfam07495 991791007835 Putative peptidoglycan-binding domain-containing protein [Cell envelope biogenesis, outer membrane]; Region: COG3409 991791007836 Putative peptidoglycan binding domain; Region: PG_binding_1; pfam01471 991791007837 Putative peptidoglycan binding domain; Region: PG_binding_1; pfam01471 991791007838 Nitroreductase-like family 3. A subfamily of the nitroreductase family containing uncharacterized proteins that are similar to nitroreductase. Nitroreductase catalyzes the reduction of nitroaromatic compounds such as nitrotoluenes, nitrofurans and...; Region: Nitroreductase_3; cd02139 991791007839 putative FMN binding site [chemical binding]; other site 991791007840 Acetyltransferase (GNAT) domain; Region: Acetyltransf_4; pfam13420 991791007841 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 991791007842 Coenzyme A binding pocket [chemical binding]; other site 991791007843 Domain of unknown function (DUF3784); Region: DUF3784; pfam12650 991791007844 Beta-galactosidase [Carbohydrate transport and metabolism]; Region: LacA; COG1874 991791007845 Glycosyl hydrolases family 35; Region: Glyco_hydro_35; pfam01301 991791007846 Beta-galactosidase, domain 2; Region: BetaGal_dom2; smart01029 991791007847 Beta-galactosidase, domain 3; Region: BetaGal_dom3; pfam13363 991791007848 Beta-galactosidase jelly roll domain; Region: BetaGal_dom4_5; pfam13364 991791007849 Beta-galactosidase jelly roll domain; Region: BetaGal_dom4_5; pfam13364 991791007850 Zinc metalloprotease (elastase) [Amino acid transport and metabolism]; Region: LasB; COG3227 991791007851 Fungalysin/Thermolysin Propeptide Motif; Region: FTP; pfam07504 991791007852 Peptidase propeptide and YPEB domain; Region: PepSY; pfam03413 991791007853 Peptidase M4 family includes thermolysin, protealysin, aureolysin and neutral protease; Region: M4_neutral_protease; cd09597 991791007854 active site 991791007855 Zn binding site [ion binding]; other site 991791007856 Zinc metalloprotease (elastase) [Amino acid transport and metabolism]; Region: LasB; COG3227 991791007857 Fungalysin/Thermolysin Propeptide Motif; Region: FTP; pfam07504 991791007858 Peptidase propeptide and YPEB domain; Region: PepSY; pfam03413 991791007859 Multimeric flavodoxin WrbA [General function prediction only]; Region: WrbA; COG0655 991791007860 NADPH-dependent FMN reductase; Region: FMN_red; pfam03358 991791007861 dolichyl-phosphate beta-D-mannosyltransferase; Region: PLN02726 991791007862 DPM_DPG-synthase_like is a member of the Glycosyltransferase 2 superfamily; Region: DPM_DPG-synthase_like; cd04179 991791007863 Ligand binding site; other site 991791007864 Putative Catalytic site; other site 991791007865 DXD motif; other site 991791007866 putative glycosyltransferase, exosortase G-associated; Region: glyc2_xrt_Gpos1; TIGR03111 991791007867 CESA_like is the cellulose synthase superfamily; Region: CESA_like; cd06423 991791007868 DXD motif; other site 991791007869 exosortase family protein XrtG; Region: exosort_Gpos; TIGR03110 991791007870 Predicted integral membrane protein [Function unknown]; Region: COG5617 991791007871 6-pyruvoyl tetrahydropterin synthase-related domain; Region: 6_pyr_pter_rel; TIGR03112 991791007872 GtrA-like protein; Region: GtrA; pfam04138 991791007873 Multimeric flavodoxin WrbA [General function prediction only]; Region: WrbA; COG0655 991791007874 NADPH-dependent FMN reductase; Region: FMN_red; pfam03358 991791007875 Acetyltransferase (GNAT) family; Region: Acetyltransf_1; pfam00583 991791007876 Acetyltransferase (GNAT) family; Region: Acetyltransf_1; pfam00583 991791007877 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 991791007878 S-adenosylmethionine binding site [chemical binding]; other site 991791007879 Bacterial surface proteins containing Ig-like domains [Cell motility and secretion]; Region: COG5492 991791007880 Clostridial hydrophobic, with a conserved W residue, domain; Region: ChW; smart00728 991791007881 Clostridial hydrophobic, with a conserved W residue, domain; Region: ChW; smart00728 991791007882 Clostridial hydrophobic, with a conserved W residue, domain; Region: ChW; smart00728 991791007883 Clostridial hydrophobic, with a conserved W residue, domain; Region: ChW; smart00728 991791007884 Clostridial hydrophobic, with a conserved W residue, domain; Region: ChW; smart00728 991791007885 Clostridial hydrophobic, with a conserved W residue, domain; Region: ChW; smart00728 991791007886 Bacterial surface proteins containing Ig-like domains [Cell motility and secretion]; Region: COG5492 991791007887 Clostridial hydrophobic, with a conserved W residue, domain; Region: ChW; smart00728 991791007888 Clostridial hydrophobic, with a conserved W residue, domain; Region: ChW; smart00728 991791007889 Clostridial hydrophobic, with a conserved W residue, domain; Region: ChW; smart00728 991791007890 Clostridial hydrophobic, with a conserved W residue, domain; Region: ChW; smart00728 991791007891 Clostridial hydrophobic, with a conserved W residue, domain; Region: ChW; smart00728 991791007892 Clostridial hydrophobic, with a conserved W residue, domain; Region: ChW; smart00728 991791007893 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 991791007894 Zn2+ binding site [ion binding]; other site 991791007895 Mg2+ binding site [ion binding]; other site 991791007896 c-di-GMP phosphodiesterase class II (HD-GYP domain) [Signal transduction mechanisms]; Region: COG2206 991791007897 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 991791007898 Zn2+ binding site [ion binding]; other site 991791007899 Mg2+ binding site [ion binding]; other site 991791007900 PQQ-dependent catabolism-associated beta-propeller protein; Region: PQQ_ABC_repeats; TIGR03866 991791007901 40-residue YVTN family beta-propeller repeat; Region: beta_rpt_yvtn; TIGR02276 991791007902 40-residue YVTN family beta-propeller repeat; Region: beta_rpt_yvtn; TIGR02276 991791007903 40-residue YVTN family beta-propeller repeat; Region: beta_rpt_yvtn; TIGR02276 991791007904 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 991791007905 This family is most closely related to the GT1 family of glycosyltransferases. UDP-glucose-diacylglycerol glucosyltransferase (UGDG; also known as 1,2-diacylglycerol 3-glucosyltransferase) catalyzes the transfer of glucose from UDP-glucose to 1; Region: GT1_UGDG_like; cd03817 991791007906 putative ADP-binding pocket [chemical binding]; other site 991791007907 PAP2_like proteins, a super-family of histidine phosphatases and vanadium haloperoxidases, includes type 2 phosphatidic acid phosphatase or lipid phosphate phosphatase (LPP), Glucose-6-phosphatase, Phosphatidylglycerophosphatase B and bacterial acid...; Region: PAP2_like; cl00474 991791007908 Membrane-associated phospholipid phosphatase [Lipid metabolism]; Region: PgpB; COG0671 991791007909 active site 991791007910 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 991791007911 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 991791007912 ATP binding site [chemical binding]; other site 991791007913 G-X-G motif; other site 991791007914 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 991791007915 Acetyltransferases [General function prediction only]; Region: RimI; COG0456 991791007916 Coenzyme A binding pocket [chemical binding]; other site 991791007917 Co/Zn/Cd efflux system component [Inorganic ion transport and metabolism]; Region: CzcD; COG1230 991791007918 Translation_Factor_II_like: Elongation factor Tu (EF-Tu) domain II-like proteins. Elongation factor Tu consists of three structural domains, this family represents the second domain. Domain II adopts a beta barrel structure and is involved in binding to...; Region: Translation_Factor_II_like; cd01342 991791007919 FAD binding domain; Region: FAD_binding_4; pfam01565 991791007920 glycolate oxidase, subunit GlcD; Region: glcD; TIGR00387 991791007921 ribokinase/pfkB superfamily: Kinases that accept a wide variety of substrates, including carbohydrates and aromatic small molecules, all are phosphorylated at a hydroxyl group. The superfamily includes ribokinase, fructokinase, ketohexokinase; Region: ribokinase_pfkB_like; cl00192 991791007922 Ferredoxin [Energy production and conversion]; Region: NapF; COG1145 991791007923 Electron transfer flavoprotein, alpha subunit [Energy production and conversion]; Region: FixB; COG2025 991791007924 The electron transfer flavoprotein (ETF) serves as a specific electron acceptor for various mitochondrial dehydrogenases. ETF transfers electrons to the main respiratory chain via ETF-ubiquinone oxidoreductase. ETF is an heterodimer that consists of an...; Region: ETF_alpha; cd01715 991791007925 Electron transfer flavoprotein FAD-binding domain; Region: ETF_alpha; pfam00766 991791007926 The electron transfer flavoprotein (ETF) serves as a specific electron acceptor for various mitochondrial dehydrogenases. ETF transfers electrons to the main respiratory chain via ETF-ubiquinone oxidoreductase. ETF is an heterodimer that consists of an...; Region: ETF_beta; cd01714 991791007927 Ligand binding site [chemical binding]; other site 991791007928 Electron transfer flavoprotein domain; Region: ETF; pfam01012 991791007929 Transcriptional regulators [Transcription]; Region: FadR; COG2186 991791007930 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 991791007931 DNA-binding site [nucleotide binding]; DNA binding site 991791007932 FCD domain; Region: FCD; pfam07729 991791007933 ligand binding domain of Tar- and Tsr-related chemoreceptors; Region: Tar_Tsr_LBD; cl00144 991791007934 Cache domain; Region: Cache_1; pfam02743 991791007935 Methyl-accepting chemotaxis protein [Cell motility and secretion / Signal transduction mechanisms]; Region: Tar; COG0840 991791007936 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 991791007937 dimerization interface [polypeptide binding]; other site 991791007938 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 991791007939 dimer interface [polypeptide binding]; other site 991791007940 putative CheW interface [polypeptide binding]; other site 991791007941 Translation_Factor_II_like: Elongation factor Tu (EF-Tu) domain II-like proteins. Elongation factor Tu consists of three structural domains, this family represents the second domain. Domain II adopts a beta barrel structure and is involved in binding to...; Region: Translation_Factor_II_like; cl02787 991791007942 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4295 991791007943 Uncharacterized protein conserved in bacteria (DUF2263); Region: DUF2263; pfam10021 991791007944 Domain of unknown function (DUF1848); Region: DUF1848; pfam08902 991791007945 Predicted double-stranded RNA/RNA-DNA hybrid binding protein [General function prediction only]; Region: COG3341 991791007946 Caulimovirus viroplasmin; Region: Cauli_VI; pfam01693 991791007947 Bacterial RNase HI containing a hybrid binding domain (HBD) at the N-terminus; Region: RNase_HI_bacteria_HBD; cd09277 991791007948 RNA/DNA hybrid binding site [nucleotide binding]; other site 991791007949 active site 991791007950 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 991791007951 salt bridge; other site 991791007952 non-specific DNA binding site [nucleotide binding]; other site 991791007953 sequence-specific DNA binding site [nucleotide binding]; other site 991791007954 Protein of unknown function (DUF3036); Region: DUF3036; pfam11234 991791007955 Beta-mannanase [Carbohydrate transport and metabolism]; Region: ManB; COG4124 991791007956 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4994 991791007957 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 991791007958 Coenzyme A binding pocket [chemical binding]; other site 991791007959 Acetyltransferase (GNAT) domain; Region: Acetyltransf_4; pfam13420 991791007960 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 991791007961 Coenzyme A binding pocket [chemical binding]; other site 991791007962 GGGtGRT protein; Region: GGGtGRT; pfam14057 991791007963 NifU homolog involved in Fe-S cluster formation [Energy production and conversion]; Region: IscU; COG0822 991791007964 Iron-sulfur cluster scaffold-like proteins; Region: IscU_like; cl00528 991791007965 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl17173 991791007966 Putative rRNA methylase; Region: rRNA_methylase; pfam06962 991791007967 Superoxide dismutase [Inorganic ion transport and metabolism]; Region: SodA; COG0605 991791007968 Iron/manganese superoxide dismutases, C-terminal domain; Region: Sod_Fe_C; pfam02777 991791007969 Predicted transcriptional regulators [Transcription]; Region: COG1733 991791007970 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 991791007971 dimerization interface [polypeptide binding]; other site 991791007972 putative DNA binding site [nucleotide binding]; other site 991791007973 putative Zn2+ binding site [ion binding]; other site 991791007974 Uncharacterized conserved protein [Function unknown]; Region: COG5015 991791007975 Arabinogalactan endo-1,4-beta-galactosidase [Carbohydrate transport and metabolism]; Region: COG3867 991791007976 Acetyltransferases, including N-acetylases of ribosomal proteins [Translation, ribosomal structure and biogenesis]; Region: RimL; COG1670 991791007977 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 991791007978 Coenzyme A binding pocket [chemical binding]; other site 991791007979 Phosphotransferase enzyme family; Region: APH; pfam01636 991791007980 Aminoglycoside 3'-phosphotransferase (APH) and Choline Kinase (ChoK) family. The APH/ChoK family is part of a larger superfamily that includes the catalytic domains of other kinases, such as the typical serine/threonine/tyrosine protein kinases (PKs)...; Region: APH_ChoK_like; cd05120 991791007981 active site 991791007982 substrate binding site [chemical binding]; other site 991791007983 ATP binding site [chemical binding]; other site 991791007984 Methyltransferase domain; Region: Methyltransf_23; pfam13489 991791007985 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 991791007986 S-adenosylmethionine binding site [chemical binding]; other site 991791007987 Methyltransferase domain; Region: Methyltransf_23; pfam13489 991791007988 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 991791007989 S-adenosylmethionine binding site [chemical binding]; other site 991791007990 Rubrerythrin [Energy production and conversion]; Region: COG1592 991791007991 Rubrerythrin, ferritin-like diiron-binding domain; Region: Rubrerythrin; cd01041 991791007992 binuclear metal center [ion binding]; other site 991791007993 Rubredoxin, Small Modular nonheme iron binding domain containing a [Fe(SCys)4] center, present in rubrerythrin and nigerythrin and detected either N- or C-terminal to such proteins as flavin reductase, NAD(P)H-nitrite reductase, and...; Region: rubredoxin_SM; cd00729 991791007994 iron binding site [ion binding]; other site 991791007995 6-pyruvoyl tetrahydropterin synthase-related domain; Region: 6_pyr_pter_rel; TIGR03112 991791007996 active site 991791007997 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 991791007998 putative glycosyltransferase, exosortase G-associated; Region: glyc2_xrt_Gpos1; TIGR03111 991791007999 CESA_like is the cellulose synthase superfamily; Region: CESA_like; cd06423 991791008000 DXD motif; other site 991791008001 exosortase family protein XrtG; Region: exosort_Gpos; TIGR03110 991791008002 Domon-like ligand-binding domains; Region: DOMON_like; cl14783 991791008003 Firmicu-CTERM domain; Region: Firmicu_CTERM; TIGR04145 991791008004 Predicted integral membrane protein [Function unknown]; Region: COG5617 991791008005 Predicted membrane protein [Function unknown]; Region: COG1511 991791008006 YhgE/Pip N-terminal domain; Region: pip_yhgE_Nterm; TIGR03061 991791008007 YhgE/Pip C-terminal domain; Region: pip_yhgE_Cterm; TIGR03062 991791008008 Predicted membrane protein [Function unknown]; Region: COG1511 991791008009 YhgE/Pip N-terminal domain; Region: pip_yhgE_Nterm; TIGR03061 991791008010 YhgE/Pip C-terminal domain; Region: pip_yhgE_Cterm; TIGR03062 991791008011 Bacterial surface proteins containing Ig-like domains [Cell motility and secretion]; Region: COG5492 991791008012 Clostridial hydrophobic, with a conserved W residue, domain; Region: ChW; smart00728 991791008013 Clostridial hydrophobic, with a conserved W residue, domain; Region: ChW; smart00728 991791008014 Clostridial hydrophobic, with a conserved W residue, domain; Region: ChW; smart00728 991791008015 Clostridial hydrophobic, with a conserved W residue, domain; Region: ChW; smart00728 991791008016 Clostridial hydrophobic, with a conserved W residue, domain; Region: ChW; smart00728 991791008017 Clostridial hydrophobic, with a conserved W residue, domain; Region: ChW; smart00728 991791008018 6-pyruvoyl tetrahydropterin synthase-related domain; Region: 6_pyr_pter_rel; TIGR03112 991791008019 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 991791008020 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 991791008021 metal binding site [ion binding]; metal-binding site 991791008022 active site 991791008023 I-site; other site 991791008024 DPM_DPG-synthase_like is a member of the Glycosyltransferase 2 superfamily; Region: DPM_DPG-synthase_like; cd04179 991791008025 Ligand binding site; other site 991791008026 Putative Catalytic site; other site 991791008027 DXD motif; other site 991791008028 putative glycosyltransferase, exosortase G-associated; Region: glyc2_xrt_Gpos1; TIGR03111 991791008029 CESA_like is the cellulose synthase superfamily; Region: CESA_like; cd06423 991791008030 DXD motif; other site 991791008031 exosortase family protein XrtG; Region: exosort_Gpos; TIGR03110 991791008032 Domon-like ligand-binding domains; Region: DOMON_like; cl14783 991791008033 putative ligand binding site [chemical binding]; other site 991791008034 Firmicu-CTERM domain; Region: Firmicu_CTERM; TIGR04145 991791008035 6-pyruvoyl tetrahydropterin synthase-related domain; Region: 6_pyr_pter_rel; TIGR03112 991791008036 Predicted integral membrane protein [Function unknown]; Region: COG5617 991791008037 Lysine efflux permease [General function prediction only]; Region: COG1279 991791008038 Glycine/D-amino acid oxidases (deaminating) [Amino acid transport and metabolism]; Region: DadA; COG0665 991791008039 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450 991791008040 Rieske Fe-S protein [Energy production and conversion]; Region: QcrA; COG0723 991791008041 Rieske domain; a [2Fe-2S] cluster binding domain commonly found in Rieske non-heme iron oxygenase (RO) systems such as naphthalene and biphenyl dioxygenases, as well as in plant/cyanobacterial chloroplast b6f and mitochondrial cytochrome bc(1) complexes; Region: Rieske; cl00938 991791008042 iron-sulfur cluster [ion binding]; other site 991791008043 [2Fe-2S] cluster binding site [ion binding]; other site 991791008044 Protein of unknown function (DUF3892); Region: DUF3892; pfam13031 991791008045 S-adenosylmethionine decarboxylase; Provisional; Region: PRK05462 991791008046 spermidine synthase; Provisional; Region: PRK00811 991791008047 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 991791008048 S-adenosylmethionine binding site [chemical binding]; other site 991791008049 Protein of unknown function (DUF1113); Region: DUF1113; pfam06541 991791008050 probable dihydroxyacetone kinase regulator; Region: DHAK_reg; TIGR02366 991791008051 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 991791008052 hypothetical protein; Provisional; Region: PRK09273 991791008053 Ribose 5-phosphate isomerase RpiB [Carbohydrate transport and metabolism]; Region: RpiB; COG0698 991791008054 Ribose-5-phosphate isomerase; Region: DUF3666; pfam12408 991791008055 gluconate 5-dehydrogenase; Provisional; Region: PRK07097 991791008056 gluconate 5-dehydrogenase (Ga5DH)-like, classical (c) SDRs; Region: Ga5DH-like_SDR_c; cd05347 991791008057 NADP binding site [chemical binding]; other site 991791008058 homodimer interface [polypeptide binding]; other site 991791008059 active site 991791008060 AraC-like ligand binding domain; Region: AraC_binding; pfam02311 991791008061 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 991791008062 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 991791008063 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 991791008064 Cytidine deaminase zinc-binding domain. These enzymes are Zn dependent. The zinc ion in the active site plays a central role in the proposed catalytic mechanism, activating a water molecule to form a hydroxide ion that performs a nucleophilic attack on...; Region: cytidine_deaminase; cd01283 991791008065 active site 991791008066 catalytic motif [active] 991791008067 Zn binding site [ion binding]; other site 991791008068 L-fucose isomerase and related proteins [Carbohydrate transport and metabolism]; Region: FucI; COG2407 991791008069 L-fucose isomerase (FucIase) and L-arabinose isomerase (AI) family; composed of FucIase, AI and similar proteins. FucIase converts L-fucose, an aldohexose, to its ketose form, which prepares it for aldol cleavage (similar to the isomerization of glucose...; Region: L-fuc_L-ara-isomerases; cd00578 991791008070 hexamer (dimer of trimers) interface [polypeptide binding]; other site 991791008071 trimer interface [polypeptide binding]; other site 991791008072 substrate binding site [chemical binding]; other site 991791008073 Mn binding site [ion binding]; other site 991791008074 Escherichia coli xylulokinase-like D-xylulose kinases; a subgroup of the FGGY family of carbohydrate kinases; Region: FGGY_D-XK_EcXK-like; cd07808 991791008075 N- and C-terminal domain interface [polypeptide binding]; other site 991791008076 D-xylulose kinase; Region: XylB; TIGR01312 991791008077 active site 991791008078 MgATP binding site [chemical binding]; other site 991791008079 catalytic site [active] 991791008080 metal binding site [ion binding]; metal-binding site 991791008081 xylulose binding site [chemical binding]; other site 991791008082 homodimer interface [polypeptide binding]; other site 991791008083 ROK family protein (putative glucokinase); Region: ROK_glcA_fam; TIGR00744 991791008084 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cd00012 991791008085 nucleotide binding site [chemical binding]; other site 991791008086 beta-phosphoglucomutase; Region: bPGM; TIGR01990 991791008087 haloacid dehalogenase-like hydrolase; Region: HAD; cl17202 991791008088 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 991791008089 Ferritin-like superfamily of diiron-containing four-helix-bundle proteins; Region: Ferritin_like; cd00657 991791008090 dinuclear metal binding motif [ion binding]; other site 991791008091 manganese transport transcriptional regulator; Provisional; Region: PRK03902 991791008092 Iron dependent repressor, N-terminal DNA binding domain; Region: Fe_dep_repress; pfam01325 991791008093 Iron dependent repressor, metal binding and dimerisation domain; Region: Fe_dep_repr_C; pfam02742 991791008094 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cl01054 991791008095 Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer); Region: MA; smart00283 991791008096 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 991791008097 dimer interface [polypeptide binding]; other site 991791008098 putative CheW interface [polypeptide binding]; other site 991791008099 Domain of Unknown Function with PDB structure (DUF3862); Region: DUF3862; pfam12978 991791008100 SGNH_hydrolase, or GDSL_hydrolase, is a diverse family of lipases and esterases. The tertiary fold of the enzyme is substantially different from that of the alpha/beta hydrolase family and unique among all known hydrolases; its active site closely...; Region: SGNH_hydrolase; cd00229 991791008101 active site 991791008102 catalytic triad [active] 991791008103 oxyanion hole [active] 991791008104 c-di-GMP phosphodiesterase class II (HD-GYP domain) [Signal transduction mechanisms]; Region: COG2206 991791008105 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 991791008106 Zn2+ binding site [ion binding]; other site 991791008107 Mg2+ binding site [ion binding]; other site 991791008108 Lyc muramidase is an autolytic lysozyme (autolysin) from Clostridium acetobutylicum encoded by the lyc gene. Lyc has a glycosyl hydrolase family 25 (GH25) catalytic domain. Endo-N-acetylmuramidases are lysozymes (also referred to as peptidoglycan...; Region: GH25_Lyc-like; cd06525 991791008109 Glycosyl hydrolases family 25; Region: Glyco_hydro_25; pfam01183 991791008110 active site 991791008111 Putative peptidoglycan-binding domain-containing protein [Cell envelope biogenesis, outer membrane]; Region: COG3409 991791008112 Putative peptidoglycan binding domain; Region: PG_binding_1; pfam01471 991791008113 Putative peptidoglycan binding domain; Region: PG_binding_1; pfam01471 991791008114 Predicted hydrolase (metallo-beta-lactamase superfamily) [General function prediction only]; Region: ComEC; COG2333 991791008115 Metallo-beta-lactamase superfamily; Region: Lactamase_B; pfam00753 991791008116 Serine/threonine protein kinase [General function prediction only / Signal transduction mechanisms / Transcription / DNA replication, recombination, and repair]; Region: SPS1; COG0515 991791008117 Protein Kinases, catalytic domain; Region: PKc_like; cl09925 991791008118 substrate binding site [chemical binding]; other site 991791008119 activation loop (A-loop); other site 991791008120 AAA ATPase domain; Region: AAA_16; pfam13191 991791008121 Predicted ATPase [General function prediction only]; Region: COG3899 991791008122 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 991791008123 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 991791008124 metal binding site [ion binding]; metal-binding site 991791008125 active site 991791008126 I-site; other site 991791008127 GAF domain; Region: GAF_3; pfam13492 991791008128 diaminopimelate epimerase; Provisional; Region: dapF; PRK00450 991791008129 Diaminopimelate epimerase; Region: DAP_epimerase; pfam01678 991791008130 Diaminopimelate epimerase; Region: DAP_epimerase; pfam01678 991791008131 Predicted hydrolase (metallo-beta-lactamase superfamily) [General function prediction only]; Region: ComEC; COG2333 991791008132 3-ketoacyl-(acyl-carrier-protein) reductase; Provisional; Region: fabG; PRK05565 991791008133 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 991791008134 NAD(P) binding site [chemical binding]; other site 991791008135 active site 991791008136 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 991791008137 S-adenosylmethionine binding site [chemical binding]; other site 991791008138 Uncharacterized homologs of Site-2 protease (S2P), zinc metalloproteases (MEROPS family M50) which cleave transmembrane domains of substrate proteins, regulating intramembrane proteolysis (RIP) of diverse signal transduction mechanisms. Members of the...; Region: S2P-M50_like_1; cd06158 991791008139 Peptidase family M50; Region: Peptidase_M50; pfam02163 991791008140 active site 991791008141 putative substrate binding region [chemical binding]; other site 991791008142 Exopolysaccharide biosynthesis protein related to N-acetylglucosamine-1-phosphodiester alpha-N-acetylglucosaminidase [Carbohydrate transport and metabolism]; Region: EpsL; COG4632 991791008143 Uncharacterized protein conserved in bacteria [Function unknown]; Region: ErfK; COG1376 991791008144 L,D-transpeptidase catalytic domain; Region: YkuD; pfam03734 991791008145 Exopolysaccharide biosynthesis protein related to N-acetylglucosamine-1-phosphodiester alpha-N-acetylglucosaminidase [Carbohydrate transport and metabolism]; Region: EpsL; COG4632 991791008146 ferric uptake regulator; Provisional; Region: fur; PRK09462 991791008147 Ferric uptake regulator(Fur) and related metalloregulatory proteins; typically iron-dependent, DNA-binding repressors and activators; Region: Fur_like; cd07153 991791008148 metal binding site 2 [ion binding]; metal-binding site 991791008149 putative DNA binding helix; other site 991791008150 metal binding site 1 [ion binding]; metal-binding site 991791008151 dimer interface [polypeptide binding]; other site 991791008152 structural Zn2+ binding site [ion binding]; other site 991791008153 YihA (EngB) GTPase family; Region: YihA_EngB; cd01876 991791008154 G1 box; other site 991791008155 GTP/Mg2+ binding site [chemical binding]; other site 991791008156 Switch I region; other site 991791008157 G2 box; other site 991791008158 G3 box; other site 991791008159 Switch II region; other site 991791008160 G4 box; other site 991791008161 G5 box; other site 991791008162 ATP-dependent Lon protease, bacterial type [Posttranslational modification, protein turnover, chaperones]; Region: Lon; COG0466 991791008163 Found in ATP-dependent protease La (LON); Region: LON; smart00464 991791008164 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 991791008165 Walker A motif; other site 991791008166 ATP binding site [chemical binding]; other site 991791008167 Walker B motif; other site 991791008168 arginine finger; other site 991791008169 Lon protease (S16) C-terminal proteolytic domain; Region: Lon_C; pfam05362 991791008170 ATP-dependent protease LonB; Region: spore_lonB; TIGR02902 991791008171 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 991791008172 Walker A motif; other site 991791008173 ATP binding site [chemical binding]; other site 991791008174 Walker B motif; other site 991791008175 arginine finger; other site 991791008176 Lon protease (S16) C-terminal proteolytic domain; Region: Lon_C; pfam05362 991791008177 ATP-dependent protease ATP-binding subunit ClpX; Provisional; Region: clpX; PRK05342 991791008178 ClpX C4-type zinc finger; Region: zf-C4_ClpX; pfam06689 991791008179 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 991791008180 Walker A motif; other site 991791008181 ATP binding site [chemical binding]; other site 991791008182 Walker B motif; other site 991791008183 C-terminal, D2-small domain, of ClpB protein; Region: ClpB_D2-small; smart01086 991791008184 Protease subunit of ATP-dependent Clp proteases [Posttranslational modification, protein turnover, chaperones / Intracellular trafficking and secretion]; Region: ClpP; COG0740 991791008185 Caseinolytic protease (ClpP) is an ATP-dependent, highly conserved serine protease; Region: S14_ClpP_2; cd07017 991791008186 oligomer interface [polypeptide binding]; other site 991791008187 active site residues [active] 991791008188 trigger factor; Provisional; Region: tig; PRK01490 991791008189 FKBP-type peptidyl-prolyl cis-trans isomerase; Region: FKBP_C; pfam00254 991791008190 Bacterial trigger factor protein (TF) C-terminus; Region: Trigger_C; pfam05698 991791008191 Sugar phosphate isomerases/epimerases [Carbohydrate transport and metabolism]; Region: IolE; COG1082 991791008192 AP endonuclease family 2; These endonucleases play a role in DNA repair. Cleave phosphodiester bonds at apurinic or apyrimidinic sites; the alignment also contains hexulose-6-phosphate isomerases, enzymes that catalyze the epimerization of...; Region: AP2Ec; cl12060 991791008193 AP (apurinic/apyrimidinic) site pocket; other site 991791008194 Metal-binding active site; metal-binding site 991791008195 carbamoyl phosphate synthase large subunit; Reviewed; Region: carB; PRK05294 991791008196 Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289 991791008197 Carbamoyl-phosphate synthase L chain, ATP binding domain; Region: CPSase_L_D2; pfam02786 991791008198 Carbamoyl-phosphate synthetase large chain, oligomerisation domain; Region: CPSase_L_D3; pfam02787 991791008199 Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289 991791008200 ATP-grasp domain; Region: ATP-grasp_4; cl17255 991791008201 Methylglyoxal synthase-like domain from type II glutamine-dependent carbamoyl phosphate synthetase (CSP). CSP, a CarA and CarB heterodimer, catalyzes the production of carbamoyl phosphate which is subsequently employed in the metabolic pathways...; Region: MGS_CPS_II; cd01424 991791008202 IMP binding site; other site 991791008203 dimer interface [polypeptide binding]; other site 991791008204 interdomain contacts; other site 991791008205 partial ornithine binding site; other site 991791008206 carbamoyl phosphate synthase small subunit; Reviewed; Region: PRK12564 991791008207 Carbamoyl-phosphate synthase small chain, CPSase domain; Region: CPSase_sm_chain; pfam00988 991791008208 Small chain of the glutamine-dependent form of carbamoyl phosphate synthase, CPSase II; Region: GATase1_CPSase; cd01744 991791008209 catalytic site [active] 991791008210 subunit interface [polypeptide binding]; other site 991791008211 signal peptidase I, bacterial type; Region: sigpep_I_bact; TIGR02227 991791008212 The S26 Type I signal peptidase (SPase; LepB; leader peptidase B; leader peptidase I; EC 3.4.21.89) family members are essential membrane-bound serine proteases that function to cleave the amino-terminal signal peptide extension from proteins that are...; Region: S26_SPase_I; cd06530 991791008213 Catalytic site [active] 991791008214 Predicted integral membrane protein [Function unknown]; Region: COG5523 991791008215 Predicted integral membrane protein [Function unknown]; Region: COG5523 991791008216 Dihydroorotate dehydrogenase (DHOD) class 1B FMN-binding domain. DHOD catalyzes the oxidation of (S)-dihydroorotate to orotate. This is the fourth step and the only redox reaction in the de novo biosynthesis of UMP, the precursor of all pyrimidine...; Region: DHOD_1B_like; cd04740 991791008217 dihydroorotate dehydrogenase (subfamily 1) family protein; Region: pyrD_sub1_fam; TIGR01037 991791008218 heterodimer interface [polypeptide binding]; other site 991791008219 active site 991791008220 FMN binding site [chemical binding]; other site 991791008221 homodimer interface [polypeptide binding]; other site 991791008222 substrate binding site [chemical binding]; other site 991791008223 dihydroorotate dehydrogenase electron transfer subunit; Reviewed; Region: PRK00054 991791008224 FAD/NAD binding domain in the electron transfer subunit of dihydroorotate dehydrogenase. Dihydroorotate dehydrogenases (DHODs) catalyze the only redox reaction in pyrimidine de novo biosynthesis. They catalyze the oxidation of (S)-dihydroorotate to...; Region: DHOD_e_trans; cd06218 991791008225 FAD binding pocket [chemical binding]; other site 991791008226 FAD binding motif [chemical binding]; other site 991791008227 phosphate binding motif [ion binding]; other site 991791008228 beta-alpha-beta structure motif; other site 991791008229 NAD binding pocket [chemical binding]; other site 991791008230 Iron coordination center [ion binding]; other site 991791008231 Orotidine 5'-phosphate decarboxylase (ODCase) is a dimeric enzyme that decarboxylates orotidine 5'-monophosphate (OMP) to form uridine 5'-phosphate (UMP), an essential step in the pyrimidine biosynthetic pathway. In mammals, UMP synthase...; Region: OMP_decarboxylase_like; cd04725 991791008232 active site 991791008233 dimer interface [polypeptide binding]; other site 991791008234 Aspartate carbamoyltransferase, regulatory subunit [Nucleotide transport and metabolism]; Region: PyrI; COG1781 991791008235 Aspartate carbamoyltransferase regulatory chain, allosteric domain; Region: PyrI; pfam01948 991791008236 Aspartate carbamoyltransferase regulatory chain, metal binding domain; Region: PyrI_C; pfam02748 991791008237 Aspartate carbamoyltransferase, catalytic chain [Nucleotide transport and metabolism]; Region: PyrB; COG0540 991791008238 Aspartate/ornithine carbamoyltransferase, carbamoyl-P binding domain; Region: OTCace_N; pfam02729 991791008239 Aspartate/ornithine carbamoyltransferase, Asp/Orn binding domain; Region: OTCace; pfam00185 991791008240 Uncharacterized membrane-associated protein [Function unknown]; Region: DedA; COG0586 991791008241 SNARE associated Golgi protein; Region: SNARE_assoc; pfam09335 991791008242 Pyridoxamine 5'-phosphate oxidase; Region: Pyridox_oxidase; pfam01243 991791008243 Flavodoxin domain; Region: Flavodoxin_5; cl17428 991791008244 The HCP family of iron-sulfur proteins includes hybrid cluster protein (HCP), acetyl-CoA synthase (ACS), and carbon monoxide dehydrogenase (CODH), all of which contain [Fe4-S4] metal clusters at their active sites. These proteins have a conserved...; Region: HCP_like; cl14655 991791008245 4Fe-4S dicluster domain; Region: Fer4_9; pfam13187 991791008246 Uncharacterized protein related to glutamine synthetase [General function prediction only]; Region: COG3968 991791008247 Glutamine synthetase type III N terminal; Region: GSIII_N; pfam12437 991791008248 Glutamine synthetase, catalytic domain; Region: Gln-synt_C; pfam00120 991791008249 Chemotaxis phosphatase, CheZ; Region: CheZ; cl01219 991791008250 Putative stress-responsive transcriptional regulator [Transcription / Signal transduction mechanisms]; Region: PspC; COG1983 991791008251 pyruvate carboxylase; Reviewed; Region: PRK12999 991791008252 Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289 991791008253 Carbamoyl-phosphate synthase L chain, ATP binding domain; Region: CPSase_L_D2; pfam02786 991791008254 Biotin carboxylase C-terminal domain; Region: Biotin_carb_C; smart00878 991791008255 Pyruvate carboxylase and Transcarboxylase 5S, carboxyltransferase domain; Region: DRE_TIM_PC_TC_5S; cd07937 991791008256 active site 991791008257 catalytic residues [active] 991791008258 metal binding site [ion binding]; metal-binding site 991791008259 homodimer binding site [polypeptide binding]; other site 991791008260 The biotinyl-domain or biotin carboxyl carrier protein (BCCP) domain is present in all biotin-dependent enzymes, such as acetyl-CoA carboxylase, pyruvate carboxylase, propionyl-CoA carboxylase, methylcrotonyl-CoA carboxylase, geranyl-CoA carboxylase; Region: biotinyl_domain; cd06850 991791008261 carboxyltransferase (CT) interaction site; other site 991791008262 biotinylation site [posttranslational modification]; other site 991791008263 Cell division protein [Cell division and chromosome partitioning]; Region: FtsX; COG2177 991791008264 cell division ABC transporter subunit FtsX; Provisional; Region: ftsX; PRK11026 991791008265 Cell wall-associated hydrolases (invasion-associated proteins) [Cell envelope biogenesis, outer membrane]; Region: Spr; COG0791 991791008266 NlpC/P60 family; Region: NLPC_P60; pfam00877 991791008267 Escherichia coli YfcE and related proteins, metallophosphatase domain; Region: MPP_YfcE; cd00841 991791008268 Calcineurin-like phosphoesterase; Region: Metallophos; pfam00149 991791008269 active site 991791008270 metal binding site [ion binding]; metal-binding site 991791008271 homotetramer interface [polypeptide binding]; other site 991791008272 NTPase/HAM1. This family consists of the HAM1 protein and pyrophosphate-releasing xanthosine/ inosine triphosphatase. HAM1 protects the cell against mutagenesis by the base analog 6-N-hydroxylaminopurine (HAP) in E. Coli and S. cerevisiae. A...; Region: HAM1; cd00515 991791008273 active site 991791008274 dimerization interface [polypeptide binding]; other site 991791008275 ABC-type oligopeptide transport system, periplasmic component [Amino acid transport and metabolism]; Region: OppA; COG4166 991791008276 The substrate-binding component of an ABC-type oligopetide import system contains the type 2 periplasmic binding fold; Region: PBP2_OppA; cd08504 991791008277 peptide binding site [polypeptide binding]; other site 991791008278 aspartyl/glutamyl-tRNA amidotransferase subunit B; Validated; Region: gatB; PRK05477 991791008279 GatB/GatE catalytic domain; Region: GatB_N; pfam02934 991791008280 GatB domain; Region: GatB_Yqey; pfam02637 991791008281 Asp-tRNAAsn/Glu-tRNAGln amidotransferase A subunit and related amidases [Translation, ribosomal structure and biogenesis]; Region: GatA; COG0154 991791008282 aspartyl/glutamyl-tRNA amidotransferase subunit A; Reviewed; Region: gatA; PRK00012 991791008283 aspartyl/glutamyl-tRNA(Asn/Gln) amidotransferase, C subunit; Region: gatC; TIGR00135 991791008284 NAD-dependent DNA ligase LigA; Validated; Region: ligA; PRK07956 991791008285 NAD+ dependent DNA ligase adenylation domain. DNA ligases catalyze the crucial step of joining the breaks in duplex DNA during DNA replication, repair and recombination, utilizing either ATP or NAD(+) as a cofactor, but using the same basic reaction...; Region: LIGANc; cd00114 991791008286 nucleotide binding pocket [chemical binding]; other site 991791008287 K-X-D-G motif; other site 991791008288 catalytic site [active] 991791008289 NAD-dependent DNA ligase OB-fold domain; Region: DNA_ligase_OB; pfam03120 991791008290 NAD-dependent DNA ligase C4 zinc finger domain; Region: DNA_ligase_ZBD; pfam03119 991791008291 Breast Cancer Suppressor Protein (BRCA1), carboxy-terminal domain. The BRCT domain is found within many DNA damage repair and cell cycle checkpoint proteins. The unique diversity of this domain superfamily allows BRCT modules to interact forming homo...; Region: BRCT; cd00027 991791008292 Dimer interface [polypeptide binding]; other site 991791008293 BRCT sequence motif; other site 991791008294 ATP-dependent DNA helicase PcrA; Region: pcrA; TIGR01073 991791008295 Part of AAA domain; Region: AAA_19; pfam13245 991791008296 Family description; Region: UvrD_C_2; pfam13538 991791008297 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4496 991791008298 16S rRNA uridine-516 pseudouridylate synthase and related pseudouridylate synthases [Translation, ribosomal structure and biogenesis]; Region: RsuA; COG1187 991791008299 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 991791008300 RNA binding surface [nucleotide binding]; other site 991791008301 Pseudouridine synthase, Escherichia coli RsuA like; Region: PseudoU_synth_RsuA; cd02553 991791008302 active site 991791008303 uracil binding [chemical binding]; other site 991791008304 Soluble lytic murein transglycosylase and related regulatory proteins (some contain LysM/invasin domains) [Cell envelope biogenesis, outer membrane]; Region: MltE; COG0741 991791008305 Lytic Transglycosylase (LT) and Goose Egg White Lysozyme (GEWL) domain. Members include the soluble and insoluble membrane-bound LTs in bacteria, the LTs in bacteriophage lambda, as well as, the eukaryotic "goose-type" lysozymes (GEWL). LTs...; Region: LT_GEWL; cd00254 991791008306 N-acetyl-D-glucosamine binding site [chemical binding]; other site 991791008307 catalytic residue [active] 991791008308 triple tyrosine motif-containing protein; Provisional; Region: PRK14081 991791008309 Y_Y_Y domain; Region: Y_Y_Y; pfam07495 991791008310 Y_Y_Y domain; Region: Y_Y_Y; pfam07495 991791008311 Y_Y_Y domain; Region: Y_Y_Y; pfam07495 991791008312 Y_Y_Y domain; Region: Y_Y_Y; pfam07495 991791008313 Y_Y_Y domain; Region: Y_Y_Y; pfam07495 991791008314 Y_Y_Y domain; Region: Y_Y_Y; pfam07495 991791008315 pullulanase, type I; Region: pulA_typeI; TIGR02104 991791008316 Early set domain associated with the catalytic domain of pullulanase (also called dextrinase and alpha-dextrin endo-1,6-alpha glucosidase); Region: E_set_Pullulanase; cd02860 991791008317 Alpha amylase catalytic domain found in Pullulanase (also called dextrinase; alpha-dextrin endo-1,6-alpha glucosidase), limit dextrinase, and related proteins; Region: AmyAc_Pullulanase_LD-like; cd11341 991791008318 Ca binding site [ion binding]; other site 991791008319 active site 991791008320 catalytic site [active] 991791008321 glucose-6-phosphate isomerase; Provisional; Region: pgi; PRK14097 991791008322 Phosphoglucose isomerase (PGI) contains two SIS (Sugar ISomerase) domains. This classification is based on the alignment of the first SIS domain. PGI is a multifunctional enzyme which as an intracellular dimer catalyzes the reversible isomerization of...; Region: SIS_PGI_1; cd05015 991791008323 active site 991791008324 dimer interface [polypeptide binding]; other site 991791008325 Phosphoglucose isomerase (PGI) contains two SIS (Sugar ISomerase) domains. This classification is based on the alignment of the second SIS domain. PGI is a multifunctional enzyme which as an intracellular dimer catalyzes the reversible isomerization of...; Region: SIS_PGI_2; cd05016 991791008326 dimer interface [polypeptide binding]; other site 991791008327 active site 991791008328 Domain of unknown function (DUF4325); Region: DUF4325; pfam14213 991791008329 Coat F domain; Region: Coat_F; pfam07875 991791008330 Sugar kinases, ribokinase family [Carbohydrate transport and metabolism]; Region: RbsK; COG0524 991791008331 2-keto-3-deoxygluconate kinase (KdgK) phosphorylates 2-keto-3-deoxygluconate (KDG) to form 2-keto-3-deoxy-6-phosphogluconate (KDGP). KDG is the common intermediate product, that allows organisms to channel D-glucuronate and/or D-galacturinate into the...; Region: KdgK; cd01166 991791008332 substrate binding site [chemical binding]; other site 991791008333 ATP binding site [chemical binding]; other site 991791008334 maltose phosphorylase; Provisional; Region: PRK13807 991791008335 Glycosyl hydrolase family 65, N-terminal domain; Region: Glyco_hydro_65N; pfam03636 991791008336 Glycosyl hydrolase family 65 central catalytic domain; Region: Glyco_hydro_65m; pfam03632 991791008337 Glycosyl hydrolase family 65, C-terminal domain; Region: Glyco_hydro_65C; pfam03633 991791008338 Glycosidases [Carbohydrate transport and metabolism]; Region: AmyA; COG0366 991791008339 Alpha amylase catalytic domain found in eukaryotic and bacterial cyclomaltodextrinases and related proteins; Region: AmyAc_euk_bac_CMD_like; cd11353 991791008340 active site 991791008341 catalytic site [active] 991791008342 ATP-dependent DNA helicase RecQ; Region: recQ; TIGR01389 991791008343 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 991791008344 ATP binding site [chemical binding]; other site 991791008345 putative Mg++ binding site [ion binding]; other site 991791008346 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 991791008347 nucleotide binding region [chemical binding]; other site 991791008348 ATP-binding site [chemical binding]; other site 991791008349 This DNA-binding domain is found in the RecQ helicase among others and has a helix-turn-helix structure; Region: RQC; smart00956 991791008350 HRDC domain; Region: HRDC; pfam00570 991791008351 Alpha/beta hydrolase of unknown function (DUF1057); Region: DUF1057; pfam06342 991791008352 Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596 991791008353 TAP-like protein; Region: Abhydrolase_4; pfam08386 991791008354 Putative amidase domain; Region: Amidase_6; pfam12671 991791008355 Transcriptional regulator [Transcription]; Region: LysR; COG0583 991791008356 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 991791008357 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cd05466 991791008358 dimerization interface [polypeptide binding]; other site 991791008359 Lactate dehydrogenase and related dehydrogenases [Energy production and conversion / Coenzyme metabolism / General function prediction only]; Region: LdhA; COG1052 991791008360 Putative Lactate dehydrogenase and (R)-2-Hydroxyglutarate Dehydrogenase-like proteins, NAD-binding and catalytic domains; Region: HGDH_LDH_like; cd12185 991791008361 putative ligand binding site [chemical binding]; other site 991791008362 putative NAD binding site [chemical binding]; other site 991791008363 catalytic site [active] 991791008364 galactoside O-acetyltransferase; Reviewed; Region: lacA; PRK09527 991791008365 Maltose O-acetyltransferase (MAT) and Galactoside O-acetyltransferase (GAT): MAT and GAT catalyze the CoA-dependent acetylation of the 6-hydroxyl group of their respective sugar substrates. MAT acetylates maltose and glucose exclusively at the C6...; Region: LbH_MAT_GAT; cd03357 991791008366 active site 991791008367 substrate binding site [chemical binding]; other site 991791008368 trimer interface [polypeptide binding]; other site 991791008369 CoA binding site [chemical binding]; other site 991791008370 Bacterial SH3 domain; Region: SH3_3; pfam08239 991791008371 Helix-turn-helix domain; Region: HTH_17; cl17695 991791008372 Putative peptidoglycan-binding domain-containing protein [Cell envelope biogenesis, outer membrane]; Region: COG3409 991791008373 Putative peptidoglycan binding domain; Region: PG_binding_1; pfam01471 991791008374 GMP synthase; Reviewed; Region: guaA; PRK00074 991791008375 Type 1 glutamine amidotransferase (GATase1) domain found in GMP synthetase; Region: GATase1_GMP_Synthase; cd01742 991791008376 AMP/PPi binding site [chemical binding]; other site 991791008377 candidate oxyanion hole; other site 991791008378 catalytic triad [active] 991791008379 potential glutamine specificity residues [chemical binding]; other site 991791008380 The C-terminal domain of GMP synthetase. It contains two subdomains; the ATP pyrophosphatase domain which closes to the N-termial and the dimerization domain at C-terminal end. The ATP-PPase is a twisted, five-stranded parallel beta-sheet sandwiched...; Region: GMP_synthase_C; cd01997 991791008381 ATP Binding subdomain [chemical binding]; other site 991791008382 Ligand Binding sites [chemical binding]; other site 991791008383 Dimerization subdomain; other site 991791008384 inosine 5'-monophosphate dehydrogenase; Reviewed; Region: PRK05567 991791008385 TIM barrel proteins share a structurally conserved phosphate binding motif and in general share an eight beta/alpha closed barrel structure. Specific for this family is the conserved phosphate binding site at the edges of strands 7 and 8. The phosphate...; Region: TIM_phosphate_binding; cl17186 991791008386 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains in the inosine 5' monophosphate dehydrogenase (IMPDH) protein. IMPDH is an essential enzyme that catalyzes the first step unique to GTP synthesis, playing a...; Region: CBS_pair_IMPDH; cd04601 991791008387 IMPDH: The catalytic domain of the inosine monophosphate dehydrogenase. IMPDH catalyzes the NAD-dependent oxidation of inosine 5'-monophosphate (IMP) to xanthosine 5' monophosphate (XMP). It is a rate-limiting step in the de novo synthesis of...; Region: IMPDH; cd00381 991791008388 active site 991791008389 EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2). The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948 991791008390 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains in association with the GGDEF (DiGuanylate-Cyclase (DGC)) domain. The GGDEF domain has been suggested to be homologous to the adenylyl cyclase catalytic domain and...; Region: CBS_pair_GGDEF_assoc; cd04598 991791008391 FOG: CBS domain [General function prediction only]; Region: COG0517 991791008392 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 991791008393 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 991791008394 metal binding site [ion binding]; metal-binding site 991791008395 active site 991791008396 I-site; other site 991791008397 chaperonin GroEL; Reviewed; Region: groEL; PRK12849 991791008398 GroEL_like type I chaperonin. Chaperonins are involved in productive folding of proteins. They share a common general morphology, a double toroid of 2 stacked rings, each composed of 7-9 subunits. The symmetry of type I is seven-fold and they are found...; Region: GroEL; cd03344 991791008399 ring oligomerisation interface [polypeptide binding]; other site 991791008400 ATP/Mg binding site [chemical binding]; other site 991791008401 stacking interactions; other site 991791008402 hinge regions; other site 991791008403 Chaperonin 10 Kd subunit (cpn10 or GroES); Cpn10 cooperates with chaperonin 60 (cpn60 or GroEL), an ATPase, to assist the folding and assembly of proteins and is found in eubacterial cytosol, as well as in the matrix of mitochondria and chloroplasts. It...; Region: cpn10; cd00320 991791008404 oligomerisation interface [polypeptide binding]; other site 991791008405 mobile loop; other site 991791008406 roof hairpin; other site 991791008407 Predicted membrane protein [Function unknown]; Region: COG4478 991791008408 Uncharacterized conserved protein [Function unknown]; Region: COG0398 991791008409 SNARE associated Golgi protein; Region: SNARE_assoc; pfam09335 991791008410 3-methyladenine DNA glycosylase/8-oxoguanine DNA glycosylase [DNA replication, recombination, and repair]; Region: AlkA; COG0122 991791008411 8-oxoguanine DNA glycosylase, N-terminal domain; Region: OGG_N; pfam07934 991791008412 endonuclease III; includes endonuclease III (DNA-(apurinic or apyrimidinic site) lyase), alkylbase DNA glycosidases (Alka-family) and other DNA glycosidases; Region: ENDO3c; cd00056 991791008413 minor groove reading motif; other site 991791008414 helix-hairpin-helix signature motif; other site 991791008415 substrate binding pocket [chemical binding]; other site 991791008416 active site 991791008417 3-hydroxybutyryl-CoA dehydrogenase; Validated; Region: PRK05808 991791008418 3-hydroxyacyl-CoA dehydrogenase, NAD binding domain; Region: 3HCDH_N; pfam02737 991791008419 3-hydroxyacyl-CoA dehydrogenase, C-terminal domain; Region: 3HCDH; pfam00725 991791008420 Electron transfer flavoprotein, alpha subunit [Energy production and conversion]; Region: FixB; COG2025 991791008421 The electron transfer flavoprotein (ETF) serves as a specific electron acceptor for various mitochondrial dehydrogenases. ETF transfers electrons to the main respiratory chain via ETF-ubiquinone oxidoreductase. ETF is an heterodimer that consists of an...; Region: ETF_alpha; cd01715 991791008422 Electron transfer flavoprotein FAD-binding domain; Region: ETF_alpha; pfam00766 991791008423 The electron transfer flavoprotein (ETF) serves as a specific electron acceptor for various mitochondrial dehydrogenases. ETF transfers electrons to the main respiratory chain via ETF-ubiquinone oxidoreductase. ETF is an heterodimer that consists of an...; Region: ETF_beta; cd01714 991791008424 Ligand binding site [chemical binding]; other site 991791008425 Electron transfer flavoprotein domain; Region: ETF; pfam01012 991791008426 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 991791008427 Short chain acyl-CoA dehydrogenases and eukaryotic short/branched chain acyl-CoA dehydrogenases; Region: SCAD_SBCAD; cd01158 991791008428 FAD binding site [chemical binding]; other site 991791008429 homotetramer interface [polypeptide binding]; other site 991791008430 substrate binding pocket [chemical binding]; other site 991791008431 catalytic base [active] 991791008432 3-hydroxybutyryl-CoA dehydratase; Validated; Region: PRK05809 991791008433 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 991791008434 substrate binding site [chemical binding]; other site 991791008435 oxyanion hole (OAH) forming residues; other site 991791008436 trimer interface [polypeptide binding]; other site 991791008437 redox-sensing transcriptional repressor Rex; Provisional; Region: PRK05472 991791008438 Putative DNA-binding protein N-terminus; Region: Put_DNA-bind_N; pfam06971 991791008439 CoA binding domain; Region: CoA_binding; pfam02629 991791008440 ATPase components of ABC transporters with duplicated ATPase domains [General function prediction only]; Region: Uup; COG0488 991791008441 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 991791008442 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 991791008443 ABC transporter; Region: ABC_tran_2; pfam12848 991791008444 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 991791008445 This family includes the Gtfs, a group of homologous glycosyltransferases involved in the final stages of the biosynthesis of antibiotics vancomycin and related chloroeremomycin. Gtfs transfer sugar moieties from an activated NDP-sugar donor to the...; Region: GT1_Gtf_like; cd03784 991791008446 glycosyltransferase, MGT family; Region: MGT; TIGR01426 991791008447 active site 991791008448 TDP-binding site; other site 991791008449 acceptor substrate-binding pocket; other site 991791008450 homodimer interface [polypeptide binding]; other site 991791008451 Ethanolamine ammonia-lyase, small subunit [Amino acid transport and metabolism]; Region: EutC; COG4302 991791008452 Ethanolamine ammonia-lyase, large subunit [Amino acid transport and metabolism]; Region: EutB; COG4303 991791008453 Ethanolamine ammonia lyase large subunit (EutB); Region: EutB; pfam06751 991791008454 ethanolamine permease; Region: 2A0305; TIGR00908 991791008455 Signal transduction histidine kinase; Region: H_kinase_N; pfam12282 991791008456 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: COG3920 991791008457 Histidine kinase; Region: HisKA_2; pfam07568 991791008458 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 991791008459 ATP binding site [chemical binding]; other site 991791008460 Mg2+ binding site [ion binding]; other site 991791008461 G-X-G motif; other site 991791008462 Response regulator with putative antiterminator output domain [Signal transduction mechanisms]; Region: AmiR; COG3707 991791008463 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 991791008464 active site 991791008465 phosphorylation site [posttranslational modification] 991791008466 intermolecular recognition site; other site 991791008467 dimerization interface [polypeptide binding]; other site 991791008468 ANTAR domain; Region: ANTAR; pfam03861 991791008469 Alpha-tubulin suppressor and related RCC1 domain-containing proteins [Cell division and chromosome partitioning / Cytoskeleton]; Region: ATS1; COG5184 991791008470 Regulator of chromosome condensation (RCC1) repeat; Region: RCC1_2; pfam13540 991791008471 Regulator of chromosome condensation (RCC1) repeat; Region: RCC1; pfam00415 991791008472 Regulator of chromosome condensation (RCC1) repeat; Region: RCC1; pfam00415 991791008473 Regulator of chromosome condensation (RCC1) repeat; Region: RCC1; pfam00415 991791008474 Regulator of chromosome condensation (RCC1) repeat; Region: RCC1_2; pfam13540 991791008475 dipeptidase PepV; Reviewed; Region: PRK07318 991791008476 M20 Peptidase Xaa-His dipeptidase (PepV) degrades hydrophobic dipeptides; Region: M20_PepV; cd03888 991791008477 active site 991791008478 metal binding site [ion binding]; metal-binding site 991791008479 Hydrolases of the alpha/beta superfamily [General function prediction only]; Region: COG1073 991791008480 Putative lysophospholipase; Region: Hydrolase_4; pfam12146 991791008481 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4224 991791008482 histidinol-phosphatase; Provisional; Region: PRK05588 991791008483 Polymerase and Histidinol Phosphatase domain; Region: PHP; cl17102 991791008484 active site 991791008485 Uncharacterized protein with a bacterial SH3 domain homologue [Function unknown]; Region: COG4991 991791008486 Bacterial SH3 domain; Region: SH3_3; pfam08239 991791008487 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 991791008488 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 991791008489 dimer interface [polypeptide binding]; other site 991791008490 phosphorylation site [posttranslational modification] 991791008491 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 991791008492 ATP binding site [chemical binding]; other site 991791008493 Mg2+ binding site [ion binding]; other site 991791008494 G-X-G motif; other site 991791008495 MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704 991791008496 FtsX-like permease family; Region: FtsX; pfam02687 991791008497 ABC-type antimicrobial peptide transport system, permease component [Defense mechanisms]; Region: SalY; COG0577 991791008498 FtsX-like permease family; Region: FtsX; pfam02687 991791008499 ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136 991791008500 ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255 991791008501 Walker A/P-loop; other site 991791008502 ATP binding site [chemical binding]; other site 991791008503 Q-loop/lid; other site 991791008504 ABC transporter signature motif; other site 991791008505 Walker B; other site 991791008506 D-loop; other site 991791008507 H-loop/switch region; other site 991791008508 ABC-type transport system involved in multi-copper enzyme maturation, permease component [General function prediction only]; Region: NosY; COG1277 991791008509 ABC-2 family transporter protein; Region: ABC2_membrane_4; pfam12730 991791008510 ABC-type multidrug transport system, ATPase component [Defense mechanisms]; Region: CcmA; COG1131 991791008511 ATP-binding cassette domain of the bacitracin-resistance transporter; Region: ABC_BcrA_bacitracin_resist; cd03268 991791008512 Walker A/P-loop; other site 991791008513 ATP binding site [chemical binding]; other site 991791008514 Q-loop/lid; other site 991791008515 ABC transporter signature motif; other site 991791008516 Walker B; other site 991791008517 D-loop; other site 991791008518 H-loop/switch region; other site 991791008519 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 991791008520 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 991791008521 active site 991791008522 phosphorylation site [posttranslational modification] 991791008523 intermolecular recognition site; other site 991791008524 dimerization interface [polypeptide binding]; other site 991791008525 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 991791008526 DNA binding site [nucleotide binding] 991791008527 ATP-binding cassette domain of sbcCD; Region: ABC_sbcCD; cd03279 991791008528 AAA domain; Region: AAA_23; pfam13476 991791008529 Walker A/P-loop; other site 991791008530 ATP binding site [chemical binding]; other site 991791008531 Q-loop/lid; other site 991791008532 ATPase involved in DNA repair [DNA replication, recombination, and repair]; Region: SbcC; COG0419 991791008533 Cytochrome P450; Region: p450; cl12078 991791008534 ATP-binding cassette domain of sbcCD; Region: ABC_sbcCD; cd03279 991791008535 ABC transporter signature motif; other site 991791008536 Walker B; other site 991791008537 D-loop; other site 991791008538 H-loop/switch region; other site 991791008539 Mre11 nuclease, N-terminal metallophosphatase domain; Region: MPP_Mre11_N; cd00840 991791008540 Calcineurin-like phosphoesterase; Region: Metallophos; pfam00149 991791008541 active site 991791008542 metal binding site [ion binding]; metal-binding site 991791008543 DNA binding site [nucleotide binding] 991791008544 Type 5 capsule protein repressor C-terminal domain; Region: SbcD_C; pfam12320 991791008545 Uncharacterized conserved protein [Function unknown]; Region: COG2013 991791008546 Acetyltransferase (GNAT) domain; Region: Acetyltransf_3; pfam13302 991791008547 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 991791008548 Coenzyme A binding pocket [chemical binding]; other site 991791008549 Histidyl-tRNA synthetase [Translation, ribosomal structure and biogenesis]; Region: HisS; COG0124 991791008550 Class II Histidinyl-tRNA synthetase (HisRS)-like catalytic core domain. HisRS is a homodimer. It is responsible for the attachment of histidine to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for...; Region: HisRS-like_core; cd00773 991791008551 dimer interface [polypeptide binding]; other site 991791008552 motif 1; other site 991791008553 active site 991791008554 motif 2; other site 991791008555 motif 3; other site 991791008556 HisRS Histidyl-anticodon binding domain. HisRS belongs to class II aminoacyl-tRNA synthetases (aaRS). This alignment contains the anticodon binding domain, which is responsible for specificity in tRNA-binding, so that the activated amino acid is...; Region: HisRS_anticodon; cd00859 991791008557 anticodon binding site; other site 991791008558 Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067 991791008559 catalytic core [active] 991791008560 Histidine phosphatase domain found in a functionally diverse set of proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP; cd07040 991791008561 Permeases of the major facilitator superfamily [General function prediction only]; Region: COG2270 991791008562 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 991791008563 putative substrate translocation pore; other site 991791008564 Protein of unknown function (DUF1113); Region: DUF1113; pfam06541 991791008565 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 991791008566 dimer interface [polypeptide binding]; other site 991791008567 putative CheW interface [polypeptide binding]; other site 991791008568 Four helix bundle sensory module for signal transduction; Region: 4HB_MCP_1; pfam12729 991791008569 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 991791008570 Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer); Region: MA; smart00283 991791008571 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 991791008572 dimer interface [polypeptide binding]; other site 991791008573 putative CheW interface [polypeptide binding]; other site 991791008574 Predicted glycosyl hydrolase [General function prediction only]; Region: COG3858 991791008575 Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118 991791008576 Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118 991791008577 Cortical fragment-lytic enzyme (CFLE) is a peptidoglycan hydrolase involved in bacterial endospore germination. CFLE is expressed as an inactive preprotein (called SleB) in the forespore compartment of sporulating cells. SleB translocates across the...; Region: GH18_CFLE_spore_hydrolase; cd02874 991791008578 active site 991791008579 Superfamily II DNA and RNA helicases [DNA replication, recombination, and repair / Transcription / Translation, ribosomal structure and biogenesis]; Region: SrmB; COG0513 991791008580 DEAD-box helicases. A diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker B motif; Region: DEADc; cd00268 991791008581 ATP binding site [chemical binding]; other site 991791008582 Mg++ binding site [ion binding]; other site 991791008583 motif III; other site 991791008584 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 991791008585 nucleotide binding region [chemical binding]; other site 991791008586 ATP-binding site [chemical binding]; other site 991791008587 RNA recognition motif in Bacillus subtilis ATP-dependent RNA helicase YxiN and similar proteins; Region: RRM_BsYxiN_like; cd12500 991791008588 RNA binding site [nucleotide binding]; other site 991791008589 Escherichia coli YfcE and related proteins, metallophosphatase domain; Region: MPP_YfcE; cd00841 991791008590 Calcineurin-like phosphoesterase; Region: Metallophos; pfam00149 991791008591 active site 991791008592 metal binding site [ion binding]; metal-binding site 991791008593 homotetramer interface [polypeptide binding]; other site 991791008594 hybrid cluster protein; Provisional; Region: PRK05290 991791008595 The HCP family of iron-sulfur proteins includes hybrid cluster protein (HCP), acetyl-CoA synthase (ACS), and carbon monoxide dehydrogenase (CODH), all of which contain [Fe4-S4] metal clusters at their active sites. These proteins have a conserved...; Region: HCP_like; cl14655 991791008596 ACS interaction site; other site 991791008597 CODH interaction site; other site 991791008598 Hybrid cluster protein (HCP), formerly known as prismane, is thought to play a role in nitrogen metabolism but its specific function is unknown. HCP has three structural domains, an N-terminal alpha-helical domain, and two similar domains comprising a...; Region: HCP; cd01914 991791008599 hybrid metal cluster; other site 991791008600 Acetyltransferase (GNAT) domain; Region: Acetyltransf_8; pfam13523 991791008601 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 991791008602 Coenzyme A binding pocket [chemical binding]; other site 991791008603 Predicted membrane protein [Function unknown]; Region: COG4684 991791008604 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 991791008605 Major Facilitator Superfamily; Region: MFS_1; pfam07690 991791008606 putative substrate translocation pore; other site 991791008607 Exonuclease-Endonuclease-Phosphatase (EEP) domain superfamily; Region: EEP; cl00490 991791008608 putative catalytic site [active] 991791008609 putative phosphate binding site [ion binding]; other site 991791008610 putative metal binding site [ion binding]; other site 991791008611 Jacalin-like lectin domains of putative endonucleases/exonucleases/phosphatases and related proteins; Region: Jacalin_EEP; cd09615 991791008612 putative sugar binding site [chemical binding]; other site 991791008613 ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132 991791008614 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 991791008615 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 991791008616 Walker A/P-loop; other site 991791008617 ATP binding site [chemical binding]; other site 991791008618 Q-loop/lid; other site 991791008619 ABC transporter signature motif; other site 991791008620 Walker B; other site 991791008621 D-loop; other site 991791008622 H-loop/switch region; other site 991791008623 ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132 991791008624 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 991791008625 ATP-binding cassette domain of glucan transporter and related proteins, subfamily C; Region: ABCC_Glucan_exporter_like; cd03254 991791008626 Walker A/P-loop; other site 991791008627 ATP binding site [chemical binding]; other site 991791008628 Q-loop/lid; other site 991791008629 ABC transporter signature motif; other site 991791008630 Walker B; other site 991791008631 D-loop; other site 991791008632 H-loop/switch region; other site 991791008633 Predicted secreted protein [Function unknown]; Region: COG4086 991791008634 Protein of unknown function (DUF1002); Region: DUF1002; pfam06207 991791008635 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 991791008636 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 991791008637 active site 991791008638 phosphorylation site [posttranslational modification] 991791008639 intermolecular recognition site; other site 991791008640 dimerization interface [polypeptide binding]; other site 991791008641 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 991791008642 DNA binding site [nucleotide binding] 991791008643 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 991791008644 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 991791008645 dimerization interface [polypeptide binding]; other site 991791008646 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 991791008647 dimer interface [polypeptide binding]; other site 991791008648 phosphorylation site [posttranslational modification] 991791008649 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 991791008650 ATP binding site [chemical binding]; other site 991791008651 Mg2+ binding site [ion binding]; other site 991791008652 G-X-G motif; other site 991791008653 Membrane-associated lipoprotein involved in thiamine biosynthesis [Coenzyme metabolism]; Region: ApbE; COG1477 991791008654 ApbE family; Region: ApbE; pfam02424 991791008655 4Fe-4S binding domain; Region: Fer4_5; pfam12801 991791008656 4Fe-4S binding domain; Region: Fer4_5; pfam12801 991791008657 4Fe-4S dicluster domain; Region: Fer4_9; pfam13187 991791008658 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3976 991791008659 Four helix bundle sensory module for signal transduction; Region: 4HB_MCP_1; pfam12729 991791008660 Methyl-accepting chemotaxis protein [Cell motility and secretion / Signal transduction mechanisms]; Region: Tar; COG0840 991791008661 HAMP domain; Region: HAMP; pfam00672 991791008662 dimerization interface [polypeptide binding]; other site 991791008663 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 991791008664 dimer interface [polypeptide binding]; other site 991791008665 putative CheW interface [polypeptide binding]; other site 991791008666 Four helix bundle sensory module for signal transduction; Region: 4HB_MCP_1; pfam12729 991791008667 Membrane-associated lipoprotein involved in thiamine biosynthesis [Coenzyme metabolism]; Region: ApbE; COG1477 991791008668 ApbE family; Region: ApbE; pfam02424 991791008669 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3976 991791008670 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 991791008671 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 991791008672 cyclophilin: cyclophilin-type peptidylprolyl cis- trans isomerases. This family contains eukaryotic, bacterial and archeal proteins which exhibit a peptidylprolyl cis- trans isomerases activity (PPIase, Rotamase) and in addition bind the...; Region: cyclophilin; cd00317 991791008673 active site 991791008674 amino acid transporter; Region: 2A0306; TIGR00909 991791008675 C-terminus of AA_permease; Region: AA_permease_C; pfam13906 991791008676 Xanthine/uracil/vitamin C permease [Nucleotide transport and metabolism]; Region: COG2252 991791008677 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 991791008678 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 991791008679 WHG domain; Region: WHG; pfam13305 991791008680 Cache domain; Region: Cache_2; pfam08269 991791008681 Methyl-accepting chemotaxis protein [Cell motility and secretion / Signal transduction mechanisms]; Region: Tar; COG0840 991791008682 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 991791008683 dimerization interface [polypeptide binding]; other site 991791008684 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 991791008685 dimer interface [polypeptide binding]; other site 991791008686 putative CheW interface [polypeptide binding]; other site 991791008687 Bacillus subtilis YkuE and related proteins, C-terminal metallophosphatase domain; Region: MPP_YkuE_C; cd07385 991791008688 Calcineurin-like phosphoesterase; Region: Metallophos; pfam00149 991791008689 putative active site [active] 991791008690 putative metal binding site [ion binding]; other site 991791008691 NrdH-redoxin (NrdH) family; NrdH is a small monomeric protein with a conserved redox active CXXC motif within a TRX fold, characterized by a glutaredoxin (GRX)-like sequence and TRX-like activity profile. In vitro, it displays protein disulfide reductase...; Region: NrdH; cd02976 991791008692 catalytic residues [active] 991791008693 Rubredoxin [Energy production and conversion]; Region: COG1773 991791008694 Rubredoxin; nonheme iron binding domains containing a [Fe(SCys)4] center. Rubredoxins are small nonheme iron proteins. The iron atom is coordinated by four cysteine residues (Fe(S-Cys)4), but iron can also be replaced by cobalt, nickel or zinc. They are...; Region: rubredoxin; cd00730 991791008695 iron binding site [ion binding]; other site 991791008696 Spore coat protein [Cell envelope biogenesis, outer membrane]; Region: COG5577 991791008697 Permeases of the drug/metabolite transporter (DMT) superfamily [Carbohydrate transport and metabolism / Amino acid transport and metabolism / General function prediction only]; Region: RhaT; COG0697 991791008698 EamA-like transporter family; Region: EamA; pfam00892 991791008699 EamA-like transporter family; Region: EamA; pfam00892 991791008700 O-acetylhomoserine sulfhydrylase [Amino acid transport and metabolism]; Region: MET17; COG2873 991791008701 CGS_like: Cystathionine gamma-synthase is a PLP dependent enzyme and catalyzes the committed step of methionine biosynthesis. This pathway is unique to microorganisms and plants, rendering the enzyme an attractive target for the development of...; Region: CGS_like; cd00614 991791008702 homodimer interface [polypeptide binding]; other site 991791008703 substrate-cofactor binding pocket; other site 991791008704 pyridoxal 5'-phosphate binding site [chemical binding]; other site 991791008705 catalytic residue [active] 991791008706 Type II secretory pathway, prepilin signal peptidase PulO and related peptidases [Cell motility and secretion / Posttranslational modification, protein turnover, chaperones / Intracellular trafficking and secretion]; Region: PulO; COG1989 991791008707 Bacterial Peptidase A24 N-terminal domain; Region: DiS_P_DiS; pfam06750 991791008708 Domain of unknown function DUF77; Region: DUF77; pfam01910 991791008709 phosphoprotein phosphatases of the metallophosphatase superfamily, metallophosphatase domain; Region: MPP_PPP_family; cd00144 991791008710 Calcineurin-like phosphoesterase; Region: Metallophos; pfam00149 991791008711 active site 991791008712 metal binding site [ion binding]; metal-binding site 991791008713 Xaa-Pro aminopeptidase [Amino acid transport and metabolism]; Region: PepP; COG0006 991791008714 Creatinase/Prolidase N-terminal domain; Region: Creatinase_N; pfam01321 991791008715 Similar to Prolidase and Aminopeptidase P. The members of this subfamily presumably catalyse hydrolysis of Xaa-Pro dipeptides and/or release of any N-terminal amino acid, including proline, that is linked with proline; Region: APP-like; cd01092 991791008716 active site 991791008717 Predicted Fe-S oxidoreductases [General function prediction only]; Region: COG0535 991791008718 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 991791008719 FeS/SAM binding site; other site 991791008720 Predicted membrane protein/domain [Function unknown]; Region: COG1714 991791008721 Transcriptional regulators [Transcription]; Region: Lrp; COG1522 991791008722 Transcriptional regulators [Transcription]; Region: Lrp; COG1522 991791008723 Winged helix-turn-helix DNA-binding; Region: HTH_24; pfam13412 991791008724 putative DNA binding site [nucleotide binding]; other site 991791008725 putative Zn2+ binding site [ion binding]; other site 991791008726 putative heme d1 biosynthesis radical SAM protein NirJ2; Region: rSAM_NirJ2; TIGR04055 991791008727 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 991791008728 FeS/SAM binding site; other site 991791008729 radical SAM additional 4Fe4S-binding SPASM domain; Region: rSAM_more_4Fe4S; TIGR04085 991791008730 putative heme d1 biosynthesis radical SAM protein NirJ1; Region: rSAM_NirJ1; TIGR04054 991791008731 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 991791008732 FeS/SAM binding site; other site 991791008733 Domain of unknown function (DUF4008); Region: DUF4008; cl14869 991791008734 NADH:flavin oxidoreductases, Old Yellow Enzyme family [Energy production and conversion]; Region: NemA; COG1902 991791008735 Old yellow enzyme (OYE)-like FMN binding domain. OYE was the first flavin-dependent enzyme identified, however its true physiological role remains elusive to this day. Each monomer of OYE contains FMN as a non-covalently bound cofactor, uses NADPH as a...; Region: OYE_like_FMN_family; cd02803 991791008736 active site 991791008737 FMN binding site [chemical binding]; other site 991791008738 substrate binding site [chemical binding]; other site 991791008739 putative catalytic residue [active] 991791008740 Domain of Unknown Function (DUF1259); Region: DUF1529; pfam07485 991791008741 Manganese catalase, ferritin-like diiron-binding domain; Region: Mn_catalase; cd01051 991791008742 dimanganese center [ion binding]; other site 991791008743 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 991791008744 TPR motif; other site 991791008745 Tetratricopeptide repeat; Region: TPR_12; pfam13424 991791008746 binding surface 991791008747 Phosphoglycerol transferase and related proteins, alkaline phosphatase superfamily [Cell envelope biogenesis, outer membrane]; Region: MdoB; COG1368 991791008748 Sulfatase; Region: Sulfatase; pfam00884 991791008749 Four helix bundle sensory module for signal transduction; Region: 4HB_MCP_1; pfam12729 991791008750 Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer); Region: MA; smart00283 991791008751 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 991791008752 dimer interface [polypeptide binding]; other site 991791008753 putative CheW interface [polypeptide binding]; other site 991791008754 Metallo-beta-lactamase superfamily; Region: Lactamase_B; smart00849 991791008755 Selenocysteine lyase/Cysteine desulfurase [Posttranslational modification, protein turnover, chaperones]; Region: csdA; COG0520 991791008756 Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321 991791008757 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 991791008758 catalytic residue [active] 991791008759 Saccharomyces cerevisiae DCR2 phosphatase and related proteins, metallophosphatase domain; Region: MPP_Dcr2; cd07383 991791008760 Calcineurin-like phosphoesterase; Region: Metallophos; pfam00149 991791008761 putative active site [active] 991791008762 putative metal binding site [ion binding]; other site 991791008763 Saccharomyces cerevisiae DCR2 phosphatase and related proteins, metallophosphatase domain; Region: MPP_Dcr2; cd07383 991791008764 Beta-glucanase/Beta-glucan synthetase [Carbohydrate transport and metabolism]; Region: SKN1; COG2273 991791008765 lichenase, member of glycosyl hydrolase family 16; Region: GH16_lichenase; cd02175 991791008766 active site 991791008767 active site 991791008768 catalytic residues [active] 991791008769 Beta-lactamase class C and other penicillin binding proteins [Defense mechanisms]; Region: AmpC; COG1680 991791008770 Beta-lactamase; Region: Beta-lactamase; pfam00144 991791008771 Predicted HD superfamily hydrolase involved in NAD metabolism [Coenzyme metabolism]; Region: COG1713 991791008772 Glucoamylase and related glycosyl hydrolases [Carbohydrate transport and metabolism]; Region: SGA1; COG3387 991791008773 DNA breaking-rejoining enzymes, intergrase/recombinases, C-terminal catalytic domain. The tyrosine recombinase/integrase family share the same catalytic domain containing six conserved active site residues. The best-studied members of this diverse family...; Region: INT_REC_C; cd01182 991791008774 active site 991791008775 Int/Topo IB signature motif; other site 991791008776 AraC-like ligand binding domain; Region: AraC_binding; pfam02311 991791008777 AraC-type DNA-binding domain-containing proteins [Transcription]; Region: AraC; COG2207 991791008778 UDP-N-acetylmuramoylalanyl-D-glutamate--2, 6-diaminopimelate ligase; Provisional; Region: murE; PRK00139 991791008779 Mur ligase family, catalytic domain; Region: Mur_ligase; pfam01225 991791008780 Mur ligase middle domain; Region: Mur_ligase_M; pfam08245 991791008781 Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875 991791008782 Xanthine/uracil/vitamin C permease [Nucleotide transport and metabolism]; Region: COG2252 991791008783 Cache domain; Region: Cache_1; pfam02743 991791008784 Methyl-accepting chemotaxis protein [Cell motility and secretion / Signal transduction mechanisms]; Region: Tar; COG0840 991791008785 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 991791008786 dimerization interface [polypeptide binding]; other site 991791008787 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 991791008788 dimer interface [polypeptide binding]; other site 991791008789 putative CheW interface [polypeptide binding]; other site 991791008790 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 991791008791 binding surface 991791008792 TPR motif; other site 991791008793 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 991791008794 binding surface 991791008795 TPR motif; other site 991791008796 Nucleoside Triphosphate Pyrophosphohydrolase (EC 3.6.1.8) MazG-like domain found in a group of uncharacterized proteins from archaea and bacteria; Region: NTP-PPase_COG4997; cd11532 991791008797 metal binding site [ion binding]; metal-binding site 991791008798 N-terminal putative catalytic domain of uncharacterized prokaryotic and archeal HKD family nucleases fused to a DEAD/DEAH box helicase domain; Region: PLDc_N_DEXD_b3; cd09205 991791008799 PLD-like domain; Region: PLDc_2; pfam13091 991791008800 putative homodimer interface [polypeptide binding]; other site 991791008801 putative active site [active] 991791008802 catalytic site [active] 991791008803 DEAD-like helicases superfamily; Region: DEXDc; smart00487 991791008804 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 991791008805 ATP binding site [chemical binding]; other site 991791008806 putative Mg++ binding site [ion binding]; other site 991791008807 Superfamily II DNA and RNA helicases [DNA replication, recombination, and repair / Transcription / Translation, ribosomal structure and biogenesis]; Region: SrmB; COG0513 991791008808 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 991791008809 nucleotide binding region [chemical binding]; other site 991791008810 ATP-binding site [chemical binding]; other site 991791008811 hypothetical protein; Validated; Region: PRK00124 991791008812 DJ-1 family protein; Region: not_thiJ; TIGR01383 991791008813 Type 1 glutamine amidotransferase (GATase1)-like domain found in a subgroup of proteins similar to PfpI from Pyrococcus furiosus; Region: GATase1_PfpI_2; cd03139 991791008814 conserved cys residue [active] 991791008815 Methyltransferase domain; Region: Methyltransf_23; pfam13489 991791008816 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 991791008817 S-adenosylmethionine binding site [chemical binding]; other site 991791008818 The MutT pyrophosphohydrolase is a prototypical Nudix hydrolase that catalyzes the hydrolysis of nucleoside and deoxynucleoside triphosphates (NTPs and dNTPs) by substitution at a beta-phosphorus to yield a nucleotide monophosphate (NMP) and inorganic...; Region: MutT_pyrophosphohydrolase; cd03425 991791008819 active site 991791008820 8-oxo-dGMP binding site [chemical binding]; other site 991791008821 nudix motif; other site 991791008822 metal binding site [ion binding]; metal-binding site 991791008823 Acylphosphatases [Energy production and conversion]; Region: AcyP; COG1254 991791008824 Integral membrane protein, interacts with FtsH [General function prediction only]; Region: COG0670 991791008825 Bacterial BAX inhibitor (BI)-1/YccA-like proteins; Region: BI-1-like_bacterial; cd10432 991791008826 aspartate aminotransferase; Provisional; Region: PRK06836 991791008827 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 991791008828 pyridoxal 5'-phosphate binding site [chemical binding]; other site 991791008829 homodimer interface [polypeptide binding]; other site 991791008830 catalytic residue [active] 991791008831 Sugar diacid utilization regulator [Transcription / Signal transduction mechanisms]; Region: CdaR; COG3835 991791008832 Putative sugar diacid recognition; Region: Diacid_rec; pfam05651 991791008833 PucR C-terminal helix-turn-helix domain; Region: HTH_30; pfam13556 991791008834 Glycerate kinase [Carbohydrate transport and metabolism]; Region: COG1929 991791008835 H+/gluconate symporter and related permeases [Carbohydrate transport and metabolism / Amino acid transport and metabolism]; Region: GntT; COG2610 991791008836 fructuronate transporter; Provisional; Region: PRK10034; cl15264 991791008837 ABC-type metal ion transport system, periplasmic component/surface adhesin [Inorganic ion transport and metabolism]; Region: LraI; COG0803 991791008838 Helical backbone metal receptor (TroA-like domain). These proteins have been shown to function in the ABC transport of ferric siderophores and metal ions such as Mn2+, Fe3+, Cu2+ and/or Zn2+. Their ligand binding site is formed in the interface between...; Region: TroA-like; cl00262 991791008839 intersubunit interface [polypeptide binding]; other site 991791008840 c-di-GMP phosphodiesterase class II (HD-GYP domain) [Signal transduction mechanisms]; Region: COG2206 991791008841 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 991791008842 Zn2+ binding site [ion binding]; other site 991791008843 Mg2+ binding site [ion binding]; other site 991791008844 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 991791008845 Zn2+ binding site [ion binding]; other site 991791008846 Mg2+ binding site [ion binding]; other site 991791008847 Predicted ATPase or kinase [General function prediction only]; Region: COG0802 991791008848 tRNA threonylcarbamoyl adenosine modification protein YeaZ; Region: T6A_YeaZ; TIGR03725 991791008849 Glycoprotease family; Region: Peptidase_M22; pfam00814 991791008850 ribosomal-protein-alanine acetyltransferase; Region: rimI; TIGR01575 991791008851 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 991791008852 Coenzyme A binding pocket [chemical binding]; other site 991791008853 Predicted membrane protein [Function unknown]; Region: COG3601 991791008854 Protein of unknown function (DUF3816); Region: DUF3816; pfam12822 991791008855 Transcriptional accessory protein [Transcription]; Region: Tex; COG2183 991791008856 Tex-like protein N-terminal domain; Region: Tex_N; pfam09371 991791008857 Likely ribonuclease with RNase H fold; Region: YqgFc; smart00732 991791008858 S1_Tex: The C-terminal S1 domain of a transcription accessory factor called Tex, which has been characterized in Bordetella pertussis and Pseudomonas aeruginosa. The tex gene is essential in Bortella pertusis and is named for its role in toxin expression; Region: S1_Tex; cd05685 991791008859 RNA binding site [nucleotide binding]; other site 991791008860 Predicted aminopeptidases [General function prediction only]; Region: Iap; COG2234 991791008861 Zinc peptidases M18, M20, M28, and M42; Region: Zinc_peptidase_like; cl14876 991791008862 M28 Zn-Peptidases containing a PA domain insert; Region: M28_like_PA; cd03877 991791008863 metal binding site [ion binding]; metal-binding site 991791008864 Galactose-1-phosphate uridylyltransferase [Energy production and conversion]; Region: GalT; COG1085 991791008865 Galactose-1-phosphate uridyl transferase (GalT): This enzyme plays a key role in galactose metabolism by catalysing the transfer of a uridine 5'-phosphoryl group from UDP-galactose 1-phosphate. The structure of E.coli GalT reveals that the enzyme...; Region: GalT; cd00608 991791008866 dimer interface [polypeptide binding]; other site 991791008867 active site 991791008868 peptide chain release factor 2; Provisional; Region: PRK05589 991791008869 This domain is found in peptide chain release factors; Region: PCRF; smart00937 991791008870 RF-1 domain; Region: RF-1; pfam00472 991791008871 preprotein translocase subunit SecA; Reviewed; Region: PRK12904 991791008872 SecA preprotein cross-linking domain; Region: SecA_PP_bind; smart00958 991791008873 SEC-C motif; Region: SEC-C; pfam02810 991791008874 RaiA ("ribosome-associated inhibitor A", also known as Protein Y (PY), YfiA, and SpotY, is a stress-response protein that binds the ribosomal subunit interface and arrests translation by interfering with aminoacyl-tRNA binding to the ribosomal...; Region: RaiA; cd00552 991791008875 30S subunit binding site; other site 991791008876 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 991791008877 dimer interface [polypeptide binding]; other site 991791008878 conserved gate region; other site 991791008879 putative PBP binding loops; other site 991791008880 ABC-ATPase subunit interface; other site 991791008881 Periplasmic glycine betaine/choline-binding (lipo)protein of an ABC-type transport system (osmoprotectant binding protein) [Cell envelope biogenesis, outer membrane]; Region: OpuBC; COG1732 991791008882 ABC-type proline/glycine betaine transport systems, ATPase components [Amino acid transport and metabolism]; Region: OpuBA; COG1125 991791008883 ATP-binding cassette domain of the osmoprotectant transporter; Region: ABC_OpuCA_Osmoprotection; cd03295 991791008884 Walker A/P-loop; other site 991791008885 ATP binding site [chemical binding]; other site 991791008886 Q-loop/lid; other site 991791008887 ABC transporter signature motif; other site 991791008888 Walker B; other site 991791008889 D-loop; other site 991791008890 H-loop/switch region; other site 991791008891 FOG: CBS domain [General function prediction only]; Region: COG0517 991791008892 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains in association with the ABC transporter OpuCA. OpuCA is the ATP binding component of a bacterial solute transporter that serves a protective role to cells growing...; Region: CBS_pair_ABC_OpuCA_assoc2; cd04583 991791008893 Predicted transcriptional regulators [Transcription]; Region: COG1725 991791008894 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 991791008895 DNA-binding site [nucleotide binding]; DNA binding site 991791008896 Putative regulatory, ligand-binding protein related to C-terminal domains of K+ channels [Inorganic ion transport and metabolism]; Region: COG0490 991791008897 TrkA-C domain; Region: TrkA_C; pfam02080 991791008898 Predicted amidophosphoribosyltransferases [General function prediction only]; Region: ComFC; COG1040 991791008899 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 991791008900 active site 991791008901 Superfamily II DNA/RNA helicase required for DNA uptake (late competence protein) [DNA replication, recombination, and repair]; Region: comFA; COG4098 991791008902 helicase, putative, RecD/TraA family; Region: recD_rel; TIGR01448 991791008903 AAA domain; Region: AAA_30; pfam13604 991791008904 Family description; Region: UvrD_C_2; pfam13538 991791008905 S-adenosylmethionine synthetase; Validated; Region: PRK05250 991791008906 S-adenosylmethionine synthetase, N-terminal domain; Region: S-AdoMet_synt_N; pfam00438 991791008907 S-adenosylmethionine synthetase, central domain; Region: S-AdoMet_synt_M; pfam02772 991791008908 S-adenosylmethionine synthetase, C-terminal domain; Region: S-AdoMet_synt_C; pfam02773 991791008909 Protein of unknown function (DUF1256); Region: DUF1256; pfam06866 991791008910 rod shape-determining protein Mbl; Provisional; Region: PRK13928 991791008911 MreB and similar proteins; Region: MreB_like; cd10225 991791008912 nucleotide binding site [chemical binding]; other site 991791008913 Mg binding site [ion binding]; other site 991791008914 putative protofilament interaction site [polypeptide binding]; other site 991791008915 RodZ interaction site [polypeptide binding]; other site 991791008916 Stage III sporulation protein D; Region: SpoIIID; pfam12116 991791008917 Peptidase family M23; Region: Peptidase_M23; pfam01551 991791008918 stage II sporulation protein D; Region: spore_II_D; TIGR02870 991791008919 Stage II sporulation protein; Region: SpoIID; pfam08486 991791008920 UDP-N-acetylglucosamine 1-carboxyvinyltransferase; Region: murA; TIGR01072 991791008921 UDP-N-acetylglucosamine enolpyruvyl transferase catalyzes enolpyruvyl transfer as part of the first step in the biosynthesis of peptidoglycan, a component of the bacterial cell wall. The reaction is phosphoenolpyruvate + UDP-N-acetyl-D-glucosamine =...; Region: UdpNAET; cd01555 991791008922 hinge; other site 991791008923 active site 991791008924 Protein of unknown function (DUF1779); Region: DUF1779; pfam08680 991791008925 F0F1 ATP synthase subunit epsilon; Provisional; Region: atpC; PRK13450 991791008926 mitochondrial ATP synthase delta subunit; Region: F1-ATPase_delta; cd12152 991791008927 gamma subunit interface [polypeptide binding]; other site 991791008928 epsilon subunit interface [polypeptide binding]; other site 991791008929 LBP interface [polypeptide binding]; other site 991791008930 F0F1 ATP synthase subunit beta; Validated; Region: PRK09280 991791008931 ATP synthase alpha/beta family, beta-barrel domain; Region: ATP-synt_ab_N; pfam02874 991791008932 F1 ATP synthase beta subunit, nucleotide-binding domain. The F-ATPase is found in bacterial plasma membranes, mitochondrial inner membranes and in chloroplast thylakoid membranes. It has also been found in the archaea Methanosarcina barkeri. It uses a...; Region: F1-ATPase_beta; cd01133 991791008933 alpha subunit interaction interface [polypeptide binding]; other site 991791008934 Walker A motif; other site 991791008935 ATP binding site [chemical binding]; other site 991791008936 Walker B motif; other site 991791008937 inhibitor binding site; inhibition site 991791008938 ATP synthase alpha/beta chain, C terminal domain; Region: ATP-synt_ab_C; pfam00306 991791008939 mitochondrial ATP synthase gamma subunit; Region: F1-ATPase_gamma; cd12151 991791008940 core domain interface [polypeptide binding]; other site 991791008941 delta subunit interface [polypeptide binding]; other site 991791008942 epsilon subunit interface [polypeptide binding]; other site 991791008943 F0F1 ATP synthase subunit alpha; Validated; Region: PRK09281 991791008944 ATP synthase alpha/beta family, beta-barrel domain; Region: ATP-synt_ab_N; pfam02874 991791008945 F1 ATP synthase alpha, central domain. The F-ATPase is found in bacterial plasma membranes, mitochondrial inner membranes and in chloroplast thylakoid membranes. It has also been found in the archaea Methanosarcina barkeri. It uses a proton gradient to...; Region: F1_ATPase_alpha; cd01132 991791008946 beta subunit interaction interface [polypeptide binding]; other site 991791008947 Walker A motif; other site 991791008948 ATP binding site [chemical binding]; other site 991791008949 Walker B motif; other site 991791008950 ATP synthase alpha/beta chain, C terminal domain; Region: ATP-synt_ab_C; pfam00306 991791008951 F0F1-type ATP synthase, delta subunit (mitochondrial oligomycin sensitivity protein) [Energy production and conversion]; Region: AtpH; COG0712 991791008952 ATP synthase delta (OSCP) subunit; Region: OSCP; pfam00213 991791008953 F0F1 ATP synthase subunit B; Provisional; Region: PRK13461 991791008954 F0F1 ATP synthase subunit B; Validated; Region: PRK05759 991791008955 F0F1 ATP synthase subunit C; Provisional; Region: PRK13469 991791008956 F0F1-type ATP synthase, subunit a [Energy production and conversion]; Region: AtpB; COG0356 991791008957 F0F1 ATP synthase subunit A; Validated; Region: PRK05815 991791008958 putative acyltransferase; Provisional; Region: PRK05790 991791008959 Thiolase are ubiquitous enzymes that catalyze the reversible thiolytic cleavage of 3-ketoacyl-CoA into acyl-CoA and acetyl-CoA, a 2-step reaction involving a covalent intermediate formed with a catalytic cysteine. They are found in prokaryotes and...; Region: thiolase; cd00751 991791008960 dimer interface [polypeptide binding]; other site 991791008961 active site 991791008962 UDP-N-acetylglucosamine 2-epimerase [Cell envelope biogenesis, outer membrane]; Region: WecB; COG0381 991791008963 Bacterial members of the UDP-N-Acetylglucosamine (GlcNAc) 2-Epimerase family are known to catalyze the reversible interconversion of UDP-GlcNAc and UDP-N-acetylmannosamine (UDP-ManNAc). The enzyme serves to produce an activated form of ManNAc residues; Region: GT1_UDP-GlcNAc_2-Epimerase; cd03786 991791008964 active site 991791008965 homodimer interface [polypeptide binding]; other site 991791008966 UDP-N-acetylmuramyl pentapeptide phosphotransferase/UDP-N- acetylglucosamine-1-phosphate transferase [Cell envelope biogenesis, outer membrane]; Region: Rfe; COG0472 991791008967 This subfamily contains Escherichia coli WecA, Bacillus subtilis TagO and related proteins. WecA is an UDP-N-acetylglucosamine (GlcNAc):undecaprenyl-phosphate (Und-P) GlcNAc-1-phosphate transferase that catalyzes the formation of a phosphodiester bond...; Region: GT_WecA_like; cd06853 991791008968 Mg++ binding site [ion binding]; other site 991791008969 putative catalytic motif [active] 991791008970 substrate binding site [chemical binding]; other site 991791008971 Deoxycytidylate deaminase domain. Deoxycytidylate deaminase catalyzes the deamination of dCMP to dUMP, providing the nucleotide substrate for thymidylate synthase. The enzyme binds Zn++, which is required for catalytic activity. The activity of the...; Region: deoxycytidylate_deaminase; cd01286 991791008972 catalytic motif [active] 991791008973 Zn binding site [ion binding]; other site 991791008974 ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136 991791008975 ATP-binding cassette domain of the metal-type transporters; Region: ABC_Metallic_Cations; cd03235 991791008976 ABC-type Mn2+/Zn2+ transport systems, permease components [Inorganic ion transport and metabolism]; Region: ZnuB; COG1108 991791008977 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550 991791008978 ABC-ATPase subunit interface; other site 991791008979 dimer interface [polypeptide binding]; other site 991791008980 putative PBP binding regions; other site 991791008981 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 991791008982 active site 991791008983 ribose-5-phosphate isomerase B; Provisional; Region: PRK05571 991791008984 Low molecular weight phosphatase family; Region: LMWPc; cd00115 991791008985 Low molecular weight phosphotyrosine protein phosphatase; Region: LMWPc; pfam01451 991791008986 active site 991791008987 Putative translation factor (SUA5) [Translation, ribosomal structure and biogenesis]; Region: SUA5; COG0009 991791008988 Putative GTP-binding controlling metal-binding; Region: SUA5; pfam03481 991791008989 peptide chain release factor 1; Validated; Region: prfA; PRK00591 991791008990 This domain is found in peptide chain release factors; Region: PCRF; smart00937 991791008991 RF-1 domain; Region: RF-1; pfam00472 991791008992 N5-glutamine S-adenosyl-L-methionine-dependent methyltransferase; Provisional; Region: PRK09328 991791008993 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 991791008994 S-adenosylmethionine binding site [chemical binding]; other site 991791008995 Predicted metal-dependent enzyme [General function prediction only]; Region: COG3872 991791008996 thymidine kinase; Provisional; Region: PRK04296 991791008997 50S ribosomal protein L31; Reviewed; Region: rpmE; PRK00019 991791008998 Rho termination factor, N-terminal domain; Region: Rho_N; smart00959 991791008999 transcription termination factor Rho; Provisional; Region: PRK12608 991791009000 Rho_CSD: Rho protein cold-shock domain (CSD). Rho protein is a transcription termination factor in most bacteria. In bacteria, there are two distinct mechanisms for mRNA transcription termination. In intrinsic termination, RNA polymerase and nascent mRNA...; Region: Rho_CSD; cd04459 991791009001 RNA binding site [nucleotide binding]; other site 991791009002 Transcription termination factor rho is a bacterial ATP-dependent RNA/DNA helicase. It is a homohexamer. Each monomer consists of an N-terminal domain of the OB fold, which is responsible for binding to cysteine rich nucleotides. This alignment is of the...; Region: rho_factor; cd01128 991791009003 multimer interface [polypeptide binding]; other site 991791009004 Walker A motif; other site 991791009005 ATP binding site [chemical binding]; other site 991791009006 Walker B motif; other site 991791009007 Alpha-glucosidases, family 31 of glycosyl hydrolases [Carbohydrate transport and metabolism]; Region: COG1501 991791009008 Glycosyl hydrolases family 31; Region: Glyco_hydro_31; pfam01055 991791009009 active site 991791009010 catalytic site [active] 991791009011 Chitobiase/beta-hexosaminidase C-terminal domain; Region: CHB_HEX_C; pfam03174 991791009012 Chitobiase/beta-hexosaminidase C-terminal domain; Region: CHB_HEX_C; pfam03174 991791009013 CTP synthetase; Validated; Region: pyrG; PRK05380 991791009014 CTP synthetase (CTPs) is a two-domain protein, which consists of an N-terminal synthetase domain and C-terminal glutaminase domain. The enzymes hydrolyze the amide bond of glutamine to ammonia and glutamate at the glutaminase domains and transfer nascent...; Region: CTGs; cd03113 991791009015 Catalytic site [active] 991791009016 active site 991791009017 UTP binding site [chemical binding]; other site 991791009018 Type 1 glutamine amidotransferase (GATase1) domain found in Cytidine Triphosphate Synthetase; Region: GATase1_CTP_Synthase; cd01746 991791009019 active site 991791009020 putative oxyanion hole; other site 991791009021 catalytic triad [active] 991791009022 Catalytic NodB homology domain of the carbohydrate esterase 4 superfamily; Region: CE4_SF; cl15692 991791009023 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4506 991791009024 D-alanyl-alanine synthetase A; Reviewed; Region: ddl; PRK01966 991791009025 D-ala D-ala ligase N-terminus; Region: Dala_Dala_lig_N; pfam01820 991791009026 D-ala D-ala ligase C-terminus; Region: Dala_Dala_lig_C; pfam07478 991791009027 germination protein YpeB; Region: spore_YpeB; TIGR02889 991791009028 UDP-N-acetylglucosamine:LPS N-acetylglucosamine transferase [Cell envelope biogenesis, outer membrane]; Region: MurG; COG0707 991791009029 Monogalactosyldiacylglycerol (MGDG) synthase; Region: MGDG_synth; pfam06925 991791009030 Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013 991791009031 stage II sporulation protein R; Region: spore_II_R; TIGR02837 991791009032 Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118 991791009033 spore photoproduct lyase; Region: photo_TT_lyase; cl15393 991791009034 DNA repair photolyase [DNA replication, recombination, and repair]; Region: SplB; COG1533 991791009035 spore photoproduct lyase; Region: photo_TT_lyase; cl15393 991791009036 4-diphosphocytidyl-2-C-methyl-D-erythritol kinase; Provisional; Region: ipk; PRK00128 991791009037 GHMP kinases N terminal domain; Region: GHMP_kinases_N; pfam00288 991791009038 GHMP kinases C terminal; Region: GHMP_kinases_C; pfam08544 991791009039 Domain of unknown function (DUF3794); Region: DUF3794; pfam12673 991791009040 Domain of unknown function (DUF3794); Region: DUF3794; pfam12673 991791009041 Domain of unknown function (DUF3794); Region: DUF3794; pfam12673 991791009042 Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118 991791009043 Protein of unknown function (DUF1021); Region: DUF1021; pfam06257 991791009044 YabG peptidase U57; Region: Peptidase_U57; pfam05582 991791009045 spore coat protein, CotS family; Region: spore_CotS; TIGR02906 991791009046 Aminoglycoside 3'-phosphotransferase (APH) and Choline Kinase (ChoK) family. The APH/ChoK family is part of a larger superfamily that includes the catalytic domains of other kinases, such as the typical serine/threonine/tyrosine protein kinases (PKs)...; Region: APH_ChoK_like; cl17270 991791009047 active site 991791009048 ATP binding site [chemical binding]; other site 991791009049 Aminoglycoside 3'-phosphotransferase (APH) and Choline Kinase (ChoK) family. The APH/ChoK family is part of a larger superfamily that includes the catalytic domains of other kinases, such as the typical serine/threonine/tyrosine protein kinases (PKs)...; Region: APH_ChoK_like; cd05120 991791009050 substrate binding site [chemical binding]; other site 991791009051 This family is most closely related to the GT1 family of glycosyltransferases. mtfB (mannosyltransferase B) in E. coli has been shown to direct the growth of the O9-specific polysaccharide chain. It transfers two mannoses into the position 3 of the...; Region: GT1_mtfB_like; cd03809 991791009052 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 991791009053 spore coat protein, CotS family; Region: spore_CotS; TIGR02906 991791009054 Aminoglycoside 3'-phosphotransferase (APH) and Choline Kinase (ChoK) family. The APH/ChoK family is part of a larger superfamily that includes the catalytic domains of other kinases, such as the typical serine/threonine/tyrosine protein kinases (PKs)...; Region: APH_ChoK_like; cd05120 991791009055 spore coat protein, CotS family; Region: spore_CotS; TIGR02906 991791009056 spore coat protein YsxE; Region: spore_ysxE; TIGR02904 991791009057 spore coat protein, CotS family; Region: spore_CotS; TIGR02906 991791009058 Aminoglycoside 3'-phosphotransferase (APH) and Choline Kinase (ChoK) family. The APH/ChoK family is part of a larger superfamily that includes the catalytic domains of other kinases, such as the typical serine/threonine/tyrosine protein kinases (PKs)...; Region: APH_ChoK_like; cd05120 991791009059 substrate binding site [chemical binding]; other site 991791009060 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 991791009061 This family is most closely related to the GT1 family of glycosyltransferases. mtfB (mannosyltransferase B) in E. coli has been shown to direct the growth of the O9-specific polysaccharide chain. It transfers two mannoses into the position 3 of the...; Region: GT1_mtfB_like; cd03809 991791009062 ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653 991791009063 Ketopantoate hydroxymethyltransferase (KPHMT) is the first enzyme in the pantothenate biosynthesis pathway. Ketopantoate hydroxymethyltransferase (KPHMT) catalyzes the first committed step in the biosynthesis of pantothenate (vitamin B5), which is a...; Region: KPHMT-like; cd06557 991791009064 oligomerization interface [polypeptide binding]; other site 991791009065 active site 991791009066 metal binding site [ion binding]; metal-binding site 991791009067 Pantoate-beta-alanine ligase; Region: PanC; cd00560 991791009068 pantoate--beta-alanine ligase; Region: panC; TIGR00018 991791009069 active site 991791009070 ATP-binding site [chemical binding]; other site 991791009071 pantoate-binding site; other site 991791009072 HXXH motif; other site 991791009073 Aspartate alpha-decarboxylase or L-aspartate 1-decarboxylase, a pyruvoyl group-dependent decarboxylase in beta-alanine production; Region: Asp_decarbox; cd06919 991791009074 tetramerization interface [polypeptide binding]; other site 991791009075 active site 991791009076 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 991791009077 Prolyl oligopeptidase family; Region: Peptidase_S9; pfam00326 991791009078 Phosphomannose isomerase [Carbohydrate transport and metabolism]; Region: ManA; COG1482 991791009079 Alpha-Mannosidase Binding Domain of Atg19/34; Region: ABD; cl15429 991791009080 Protein of unknown function (DUF2971); Region: DUF2971; pfam11185 991791009081 Thiamine monophosphate synthase (TMP synthase)/TenI. TMP synthase catalyzes an important step in the thiamine biosynthesis pathway, the substitution of the pyrophosphate of 2-methyl-4-amino-5- hydroxymethylpyrimidine pyrophosphate by 4-methyl-5-; Region: TMP_TenI; cd00564 991791009082 thiamine phosphate binding site [chemical binding]; other site 991791009083 active site 991791009084 pyrophosphate binding site [ion binding]; other site 991791009085 thiamine biosynthesis protein ThiH; Reviewed; Region: thiH; PRK09240 991791009086 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 991791009087 FeS/SAM binding site; other site 991791009088 Biotin and Thiamin Synthesis associated domain; Region: BATS; pfam06968 991791009089 Thiazole synthase (ThiG) is the tetrameric enzyme that is involved in the formation of the thiazole moiety of thiamin pyrophosphate, an essential ubiquitous cofactor that plays an important role in carbohydrate and amino acid metabolism. ThiG catalyzes...; Region: ThiG; cd04728 991791009090 ThiS interaction site; other site 991791009091 putative active site [active] 991791009092 tetramer interface [polypeptide binding]; other site 991791009093 ThiS-like ubiquitin; Region: ThiS-like; pfam14453 991791009094 thiamine biosynthesis protein ThiF; Provisional; Region: PRK08644 991791009095 E1_ThiF_like. Member of superfamily of activating enzymes (E1) of the ubiquitin-like proteins. The common reaction mechanism catalyzed by E1-like enzymes begins with a nucleophilic attack of the C-terminal carboxylate of the ubiquitin-like substrate, on...; Region: E1_ThiF_like; cd01487 991791009096 putative ATP binding site [chemical binding]; other site 991791009097 putative substrate interface [chemical binding]; other site 991791009098 ThiaminS ubiquitin-like sulfur carrier protein; Region: ThiS; cd00565 991791009099 thiS-thiF/thiG interaction site; other site 991791009100 Predicted HD superfamily hydrolase [General function prediction only]; Region: COG1418 991791009101 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 991791009102 Zn2+ binding site [ion binding]; other site 991791009103 Mg2+ binding site [ion binding]; other site 991791009104 DHPS subgroup of Pterin binding enzymes. DHPS (dihydropteroate synthase), a functional homodimer, catalyzes the condensation of p-aminobenzoic acid (pABA) in the de novo biosynthesis of folate, which is an essential cofactor in both nucleic acid and...; Region: DHPS; cd00739 991791009105 dihydropteroate synthase; Region: DHPS; TIGR01496 991791009106 substrate binding pocket [chemical binding]; other site 991791009107 dimer interface [polypeptide binding]; other site 991791009108 inhibitor binding site; inhibition site 991791009109 Dihydroneopterin aldolase (DHNA) and 7,8-dihydroneopterin triphosphate epimerase domain (DHNTPE); these enzymes have been designated folB and folX, respectively. Folate derivatives are essential cofactors in the biosynthesis of purines, pyrimidines, and...; Region: DHNA_DHNTPE; cd00534 991791009110 homooctamer interface [polypeptide binding]; other site 991791009111 active site 991791009112 7,8-dihydro-6-hydroxymethylpterin-pyrophosphokinase (HPPK). Folate derivatives are essential cofactors in the biosynthesis of purines, pyrimidines, and amino acids as well as formyl-tRNA. Mammalian cells are able to utilize pre-formed folates after...; Region: HPPK; cd00483 991791009113 catalytic center binding site [active] 991791009114 ATP binding site [chemical binding]; other site 991791009115 Predicted membrane protein [Function unknown]; Region: COG3859 991791009116 ABC-type Na+ efflux pump, permease component [Energy production and conversion / Inorganic ion transport and metabolism]; Region: NatB; COG1668 991791009117 YhgE/Pip N-terminal domain; Region: pip_yhgE_Nterm; TIGR03061 991791009118 ABC-2 type transporter; Region: ABC2_membrane; cl17235 991791009119 YhgE/Pip N-terminal domain; Region: pip_yhgE_Nterm; TIGR03061 991791009120 ABC-2 family transporter protein; Region: ABC2_membrane_3; pfam12698 991791009121 ABC-type multidrug transport system, ATPase component [Defense mechanisms]; Region: CcmA; COG1131 991791009122 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 991791009123 Walker A/P-loop; other site 991791009124 ATP binding site [chemical binding]; other site 991791009125 Q-loop/lid; other site 991791009126 ABC transporter signature motif; other site 991791009127 Walker B; other site 991791009128 D-loop; other site 991791009129 H-loop/switch region; other site 991791009130 RPB11 and RPB3 subunits of RNA polymerase; Region: RNAP_RPB11_RPB3; cl11409 991791009131 4Fe-4S dicluster domain; Region: Fer4_9; pfam13187 991791009132 Nitroreductase family. Members of this family utilize FMN as a cofactor. This family is involved in the reduction of flavin or nitroaromatic compounds by using NAD(P)H as electron donor in a obligatory two-electron transfer. Nitrogenase is homodimer; Region: NADH_nitroreductase; cd02143 991791009133 putative FMN binding site [chemical binding]; other site 991791009134 Predicted transcriptional regulators [Transcription]; Region: COG1733 991791009135 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 991791009136 dimerization interface [polypeptide binding]; other site 991791009137 putative DNA binding site [nucleotide binding]; other site 991791009138 putative Zn2+ binding site [ion binding]; other site 991791009139 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 991791009140 Coenzyme A binding pocket [chemical binding]; other site 991791009141 Acetyltransferases [General function prediction only]; Region: RimI; COG0456 991791009142 Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596 991791009143 Ketopantoate reductase PanE/ApbA; Region: ApbA; pfam02558 991791009144 2-dehydropantoate 2-reductase; Region: apbA_panE; TIGR00745 991791009145 Ketopantoate reductase PanE/ApbA C terminal; Region: ApbA_C; pfam08546 991791009146 This domain is found in Saccharomyces cerevisiae protein SMP2, proteins with an N-terminal lipin domain and phosphatidylinositol transfer proteins; Region: LNS2; smart00775 991791009147 LNS2 (Lipin/Ned1/Smp2); Region: LNS2; pfam08235 991791009148 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 991791009149 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 991791009150 active site 991791009151 phosphorylation site [posttranslational modification] 991791009152 intermolecular recognition site; other site 991791009153 dimerization interface [polypeptide binding]; other site 991791009154 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 991791009155 DNA binding residues [nucleotide binding] 991791009156 dimerization interface [polypeptide binding]; other site 991791009157 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: COG4585 991791009158 Histidine kinase; Region: HisKA_3; pfam07730 991791009159 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 991791009160 ATP binding site [chemical binding]; other site 991791009161 Mg2+ binding site [ion binding]; other site 991791009162 G-X-G motif; other site 991791009163 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 991791009164 haloacid dehalogenase-like hydrolase; Region: Hydrolase_3; pfam08282 991791009165 active site 991791009166 motif I; other site 991791009167 motif II; other site 991791009168 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cl17915 991791009169 S-ribosylhomocysteinase; Provisional; Region: PRK02260 991791009170 Family description; Region: VCBS; pfam13517 991791009171 Family description; Region: VCBS; pfam13517 991791009172 Family description; Region: VCBS; pfam13517 991791009173 Family description; Region: VCBS; pfam13517 991791009174 Cell wall-associated hydrolases (invasion-associated proteins) [Cell envelope biogenesis, outer membrane]; Region: Spr; COG0791 991791009175 NlpC/P60 family; Region: NLPC_P60; pfam00877 991791009176 Family description; Region: VCBS; pfam13517 991791009177 Family description; Region: VCBS; pfam13517 991791009178 Family description; Region: VCBS; pfam13517 991791009179 Family description; Region: VCBS; pfam13517 991791009180 Family description; Region: VCBS; pfam13517 991791009181 Orthopoxvirus protein of unknown function (DUF830); Region: DUF830; cl13998 991791009182 Cell wall-associated hydrolases (invasion-associated proteins) [Cell envelope biogenesis, outer membrane]; Region: Spr; COG0791 991791009183 NlpC/P60 family; Region: NLPC_P60; pfam00877 991791009184 Lactate dehydrogenase and related dehydrogenases [Energy production and conversion / Coenzyme metabolism / General function prediction only]; Region: LdhA; COG1052 991791009185 Putative D-isomer specific 2-hydroxyacid dehydrogenases; Region: 2-Hacid_dh_4; cd12162 991791009186 putative ligand binding site [chemical binding]; other site 991791009187 putative NAD binding site [chemical binding]; other site 991791009188 catalytic site [active] 991791009189 DNA topoisomerase III; Provisional; Region: PRK07726 991791009190 TOPRIM_TopoIA_TopoIII: The topoisomerase-primase (TORPIM) domain found in members of the type IA family of DNA topoisomerases (Topo IA) similar to topoisomerase III. Type IA DNA topoisomerases remove (relax) negative supercoils in the DNA by: cleaving...; Region: TOPRIM_TopoIA_TopoIII; cd03362 991791009191 active site 991791009192 putative interdomain interaction site [polypeptide binding]; other site 991791009193 putative metal-binding site [ion binding]; other site 991791009194 putative nucleotide binding site [chemical binding]; other site 991791009195 DNA Topoisomerase, subtype IA; DNA-binding, ATP-binding and catalytic domain of bacterial DNA topoisomerases I and III, and eukaryotic DNA topoisomerase III and eubacterial and archael reverse gyrases. Topoisomerases clevage single or double stranded DNA...; Region: TOP1Ac; cd00186 991791009196 domain I; other site 991791009197 DNA binding groove [nucleotide binding] 991791009198 phosphate binding site [ion binding]; other site 991791009199 domain II; other site 991791009200 domain III; other site 991791009201 nucleotide binding site [chemical binding]; other site 991791009202 catalytic site [active] 991791009203 domain IV; other site 991791009204 Zn-finger domain associated with topoisomerase type I [DNA replication, recombination, and repair]; Region: TopA; COG0551 991791009205 ABC transporter ATP-binding protein; Provisional; Region: PRK15064 991791009206 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 991791009207 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 991791009208 ABC transporter; Region: ABC_tran_2; pfam12848 991791009209 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 991791009210 Predicted permeases [General function prediction only]; Region: COG0679 991791009211 Transcriptional regulators of sugar metabolism [Transcription / Carbohydrate transport and metabolism]; Region: GlpR; COG1349 991791009212 helix_turn_helix, Deoxyribose operon repressor; Region: HTH_DEOR; smart00420 991791009213 DeoR C terminal sensor domain; Region: DeoRC; pfam00455 991791009214 Fructose-1-phosphate kinase and related fructose-6-phosphate kinase (PfkB) [Carbohydrate transport and metabolism]; Region: FruK; COG1105 991791009215 1-phosphofructokinase (FruK), minor 6-phosphofructokinase (pfkB) and related sugar kinases. FruK plays an important role in the predominant pathway for fructose utilisation.This group also contains tagatose-6-phophate kinase, an enzyme of the tagatose...; Region: FruK_PfkB_like; cd01164 991791009216 putative substrate binding site [chemical binding]; other site 991791009217 putative ATP binding site [chemical binding]; other site 991791009218 Tagatose-1,6-bisphosphate (TBP) aldolase and related Type B Class II aldolases. TBP aldolase is a tetrameric class II aldolase that catalyzes the reversible condensation of dihydroxyacetone phosphate with glyceraldehyde 3-phsophate to produce tagatose 1; Region: TBP_aldolase_IIB; cd00947 991791009219 fructose-bisphosphate aldolase; Provisional; Region: PRK09197 991791009220 intersubunit interface [polypeptide binding]; other site 991791009221 active site 991791009222 zinc binding site [ion binding]; other site 991791009223 Na+ binding site [ion binding]; other site 991791009224 galactose-6-phosphate isomerase subunit LacB; Reviewed; Region: PRK08622 991791009225 galactose-6-phosphate isomerase subunit LacA; Reviewed; Region: PRK08621 991791009226 Transcriptional regulators of sugar metabolism [Transcription / Carbohydrate transport and metabolism]; Region: GlpR; COG1349 991791009227 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 991791009228 putative DNA binding site [nucleotide binding]; other site 991791009229 putative Zn2+ binding site [ion binding]; other site 991791009230 DeoR C terminal sensor domain; Region: DeoRC; pfam00455 991791009231 Phosphotransferase system, galactitol-specific IIC component [Carbohydrate transport and metabolism]; Region: GatC; COG3775 991791009232 PTS system sugar-specific permease component; Region: EIIC-GAT; pfam03611 991791009233 Phosphotransferase system, galactitol-specific IIB component [Carbohydrate transport and metabolism]; Region: SgaB; COG3414 991791009234 active site 991791009235 P-loop; other site 991791009236 phosphorylation site [posttranslational modification] 991791009237 PTS_IIA, PTS system, fructose/mannitol specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_fru; cd00211 991791009238 active site 991791009239 phosphorylation site [posttranslational modification] 991791009240 galactokinase; Provisional; Region: PRK05322 991791009241 Galactokinase galactose-binding signature; Region: GalKase_gal_bdg; pfam10509 991791009242 GHMP kinases N terminal domain; Region: GHMP_kinases_N; pfam00288 991791009243 GHMP kinases C terminal; Region: GHMP_kinases_C; pfam08544 991791009244 UDP-glucose 4-epimerase [Cell envelope biogenesis, outer membrane]; Region: GalE; COG1087 991791009245 UDP-glucose 4 epimerase, subgroup 1, extended (e) SDRs; Region: UDP_G4E_1_SDR_e; cd05247 991791009246 NAD binding site [chemical binding]; other site 991791009247 homodimer interface [polypeptide binding]; other site 991791009248 active site 991791009249 substrate binding site [chemical binding]; other site 991791009250 Galactose-1-phosphate uridyltransferase [Carbohydrate transport and metabolism]; Region: GalT; COG4468 991791009251 Galactose-1-phosphate uridyl transferase, N-terminal domain; Region: GalP_UDP_transf; pfam01087 991791009252 Galactose-1-phosphate uridyl transferase, C-terminal domain; Region: GalP_UDP_tr_C; pfam02744 991791009253 Transcriptional regulators [Transcription]; Region: PurR; COG1609 991791009254 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 991791009255 DNA binding site [nucleotide binding] 991791009256 domain linker motif; other site 991791009257 Ligand binding domain of the LacI tanscriptional regulator family belonging to the type I periplasmic-binding fold protein superfamily; Region: PBP1_LacI_sugar_binding_like; cd06267 991791009258 dimerization interface [polypeptide binding]; other site 991791009259 ligand binding site [chemical binding]; other site 991791009260 6-phospho-beta-galactosidase; Provisional; Region: PRK13511 991791009261 beta-galactosidase; Region: BGL; TIGR03356 991791009262 Phosphotransferase system cellobiose-specific component IIC [Carbohydrate transport and metabolism]; Region: CelB; cl17295 991791009263 Phosphotransferase system, EIIC; Region: PTS_EIIC; pfam02378 991791009264 PTS_IIB_lactose: subunit IIB of enzyme II (EII) of the lactose-specific phosphoenolpyruvate:carbohydrate phosphotransferase system (PTS) found in Firmicutes as well as Actinobacteria. In this system, EII is a lactose-specific permease with two...; Region: PTS_IIB_lactose; cd05565 991791009265 active site 991791009266 P-loop; other site 991791009267 phosphorylation site [posttranslational modification] 991791009268 PTS_IIA, PTS system, lactose/cellobiose specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_lac; cd00215 991791009269 methionine cluster; other site 991791009270 active site 991791009271 phosphorylation site [posttranslational modification] 991791009272 metal binding site [ion binding]; metal-binding site 991791009273 Transcriptional regulators of sugar metabolism [Transcription / Carbohydrate transport and metabolism]; Region: GlpR; COG1349 991791009274 helix_turn_helix, Deoxyribose operon repressor; Region: HTH_DEOR; smart00420 991791009275 DeoR C terminal sensor domain; Region: DeoRC; pfam00455 991791009276 Alpha-acetolactate decarboxylase [Secondary metabolites biosynthesis, transport, and catabolism]; Region: AlsD; COG3527 991791009277 Mannose-1-phosphate guanylyltransferase [Cell envelope biogenesis, outer membrane]; Region: {ManC}; COG0836 991791009278 GDP-M1P_Guanylyltransferase catalyzes the formation of GDP-Mannose; Region: GDP-M1P_Guanylyltransferase; cd02509 991791009279 Substrate binding site; other site 991791009280 Cupin domain; Region: Cupin_2; cl17218 991791009281 Alkyladenine DNA glycosylase catalyzes the first step in base excision repair; Region: AAG; cd00540 991791009282 active site 991791009283 DNA binding site [nucleotide binding] 991791009284 Bifunctional PLP-dependent enzyme with beta-cystathionase and maltose regulon repressor activities [Amino acid transport and metabolism]; Region: MalY; COG1168 991791009285 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 991791009286 pyridoxal 5'-phosphate binding site [chemical binding]; other site 991791009287 homodimer interface [polypeptide binding]; other site 991791009288 catalytic residue [active] 991791009289 thiamine biosynthesis protein ThiI; Provisional; Region: PRK01565 991791009290 THUMP domain of thiamine biosynthesis protein ThiI; Region: THUMP_ThiI; cd11716 991791009291 ThiI is required for thiazole synthesis in the thiamine biosynthesis pathway. It belongs to the Adenosine Nucleotide Hydrolysis suoerfamily and predicted to bind to Adenosine nucleotide; Region: ThiI; cd01712 991791009292 Ligand Binding Site [chemical binding]; other site 991791009293 Cysteine sulfinate desulfinase/cysteine desulfurase and related enzymes [Amino acid transport and metabolism]; Region: NifS; COG1104 991791009294 cysteine desulfurase NifS; Region: FeS_nifS; TIGR03402 991791009295 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 991791009296 catalytic residue [active] 991791009297 2-keto-3-deoxy-6-phosphogluconate aldolase [Carbohydrate transport and metabolism]; Region: Eda; COG0800 991791009298 KDPG and KHG aldolase; Region: KDPG_aldolase; cd00452 991791009299 active site 991791009300 intersubunit interface [polypeptide binding]; other site 991791009301 catalytic residue [active] 991791009302 Collagenase and related proteases [Posttranslational modification, protein turnover, chaperones]; Region: COG0826 991791009303 Quinolinate phosphoribosyl transferase, C-terminal domain; Region: QRPTase_C; pfam01729 991791009304 Peptidase family U32; Region: Peptidase_U32; pfam01136 991791009305 aspartyl/glutamyl-tRNA amidotransferase subunit B; Validated; Region: gatB; PRK05477 991791009306 GatB/GatE catalytic domain; Region: GatB_N; pfam02934 991791009307 GatB domain; Region: GatB_Yqey; pfam02637 991791009308 Asp-tRNAAsn/Glu-tRNAGln amidotransferase A subunit and related amidases [Translation, ribosomal structure and biogenesis]; Region: GatA; COG0154 991791009309 aspartyl/glutamyl-tRNA amidotransferase subunit A; Reviewed; Region: gatA; PRK00012 991791009310 Asp-tRNAAsn/Glu-tRNAGln amidotransferase C subunit [Translation, ribosomal structure and biogenesis]; Region: GatC; COG0721 991791009311 aspartyl-tRNA synthetase; Provisional; Region: aspC; PRK05159 991791009312 Replication protein A, class 2b aminoacyl-tRNA synthetases, and related proteins with oligonucleotide/oligosaccharide (OB) fold; Region: RPA_2b-aaRSs_OBF_like; cl09930 991791009313 Dimer interface [polypeptide binding]; other site 991791009314 anticodon binding site; other site 991791009315 Asx tRNA synthetase (AspRS/AsnRS) class II core domain. Assignment to class II aminoacyl-tRNA synthetases (aaRS) based upon its structure and the presence of three characteristic sequence motifs in the core domain. This family includes AsnRS as well as...; Region: AsxRS_core; cd00776 991791009316 homodimer interface [polypeptide binding]; other site 991791009317 motif 1; other site 991791009318 motif 2; other site 991791009319 active site 991791009320 motif 3; other site 991791009321 Nucleoside-diphosphate-sugar pyrophosphorylase involved in lipopolysaccharide biosynthesis/translation initiation factor 2B, gamma/epsilon subunits (eIF-2Bgamma/eIF-2Bepsilon) [Cell envelope biogenesis, outer membrane / Translation, ribosomal structure...; Region: GCD1; COG1208 991791009322 NTP_transferases catalyze the transfer of nucleotides onto phosphosugars; Region: NTP_transferase; cd04181 991791009323 active site 991791009324 Substrate binding site; other site 991791009325 Mg++ binding site; other site 991791009326 Left-handed parallel beta-Helix (LbetaH or LbH) domain: The alignment contains 5 turns, each containing three imperfect tandem repeats of a hexapeptide repeat motif (X-[STAV]-X-[LIV]-[GAED]-X). Proteins containing hexapeptide repeats are often enzymes...; Region: LbetaH; cl00160 991791009327 putative trimer interface [polypeptide binding]; other site 991791009328 putative CoA binding site [chemical binding]; other site 991791009329 Phosphomannomutase [Carbohydrate transport and metabolism]; Region: {ManB}; COG1109 991791009330 The alpha-D-phosphohexomutase superfamily includes several related enzymes that catalyze a reversible intramolecular phosphoryl transfer on their sugar substrates. Members of this family include the phosphoglucomutases (PGM1 and PGM2), phosphoglucosamine...; Region: phosphohexomutase; cl03757 991791009331 active site 991791009332 substrate binding site [chemical binding]; other site 991791009333 metal binding site [ion binding]; metal-binding site 991791009334 ATPases involved in chromosome partitioning [Cell division and chromosome partitioning]; Region: Mrp; COG0489 991791009335 MRP (Multiple Resistance and pH adaptation) is a homologue of the Fer4_NifH superfamily. Like the other members of the superfamily, MRP contains a ATP-binding domain at the N-termini. It is found in bacteria as a membrane-spanning protein and functions...; Region: MRP-like; cd02037 991791009336 16S ribosomal RNA methyltransferase KsgA/Dim1 family protein; Reviewed; Region: ksgA; PRK00274 991791009337 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 991791009338 S-adenosylmethionine binding site [chemical binding]; other site 991791009339 ribonuclease M5; Region: 5S_RNA_mat_M5; TIGR00334 991791009340 TOPRIM_ RNase M5_like: The topoisomerase-primase (TOPRIM) nucleotidyl transferase/hydrolase domain found in Ribonuclease M5: (RNase M5) and other small primase-like proteins from bacteria and archaea. RNase M5 catalyzes the maturation of 5S rRNA in low...; Region: TOPRIM_RNase_M5_like; cd01027 991791009341 putative active site [active] 991791009342 putative metal binding site [ion binding]; other site 991791009343 Domain of unknown function (DUF4093); Region: DUF4093; pfam13331 991791009344 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3583 991791009345 Domain of unknown function (DUF348); Region: DUF348; pfam03990 991791009346 Domain of unknown function (DUF348); Region: DUF348; pfam03990 991791009347 G5 domain; Region: G5; pfam07501 991791009348 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3584 991791009349 TatD like proteins; E.coli TatD is a cytoplasmic protein, shown to have magnesium dependent DNase activity; Region: TatD_DNAse; cd01310 991791009350 active site 991791009351 Cold-Shock Protein (CSP) contains an S1-like cold-shock domain (CSD) that is found in eukaryotes, prokaryotes, and archaea. CSP's include the major cold-shock proteins CspA and CspB in bacteria and the eukaryotic gene regulatory factor Y-box...; Region: CSP_CDS; cd04458 991791009352 DNA-binding site [nucleotide binding]; DNA binding site 991791009353 RNA-binding motif; other site 991791009354 methionyl-tRNA synthetase; Reviewed; Region: PRK12267 991791009355 catalytic core domain of methioninyl-tRNA synthetases; Region: MetRS_core; cd00814 991791009356 active site 991791009357 HIGH motif; other site 991791009358 KMSKS motif; other site 991791009359 Anticodon-binding domain of methionyl tRNA synthetases; Region: Anticodon_Ia_Met; cd07957 991791009360 tRNA binding surface [nucleotide binding]; other site 991791009361 anticodon binding site; other site 991791009362 tRNA-binding-domain-containing Escherichia coli methionyl-tRNA synthetase (EcMetRS)-like proteins. This family includes EcMetRS and Aquifex aeolicus Trbp111 (AaTrbp111). This domain has general tRNA binding properties. MetRS aminoacylates methionine...; Region: tRNA_bind_EcMetRS_like; cd02800 991791009363 dimer interface [polypeptide binding]; other site 991791009364 putative tRNA-binding site [nucleotide binding]; other site 991791009365 Short-chain dehydrogenases of various substrate specificities [General function prediction only]; Region: DltE; COG0300 991791009366 classical (c) SDRs; Region: SDR_c; cd05233 991791009367 NAD(P) binding site [chemical binding]; other site 991791009368 active site 991791009369 Domain of unknown function (DUF4356); Region: DUF4356; pfam14266 991791009370 Uncharacterized protein involved in tellurite resistance [Inorganic ion transport and metabolism]; Region: TelA; COG3853 991791009371 Phosphotransferase system IIA components [Carbohydrate transport and metabolism]; Region: NagE; COG2190 991791009372 HPr interaction site; other site 991791009373 glycerol kinase (GK) interaction site [polypeptide binding]; other site 991791009374 active site 991791009375 phosphorylation site [posttranslational modification] 991791009376 Bacterial SNF2 helicase associated; Region: SNF2_assoc; pfam08455 991791009377 SNF2 family N-terminal domain; Region: SNF2_N; pfam00176 991791009378 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 991791009379 ATP binding site [chemical binding]; other site 991791009380 putative Mg++ binding site [ion binding]; other site 991791009381 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 991791009382 nucleotide binding region [chemical binding]; other site 991791009383 ATP-binding site [chemical binding]; other site 991791009384 Family 4 Uracil-DNA glycosylase (UDG), found exclusively in thermophilic organisms; Region: UDG_F4_TTUDGA_like; cd10030 991791009385 Fe-S cluster binding site [ion binding]; other site 991791009386 active site 991791009387 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 991791009388 binding surface 991791009389 TPR repeat; Region: TPR_11; pfam13414 991791009390 TPR motif; other site 991791009391 TPR repeat; Region: TPR_11; pfam13414 991791009392 TPR repeat; Region: TPR_11; pfam13414 991791009393 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 991791009394 binding surface 991791009395 TPR motif; other site 991791009396 TPR repeat; Region: TPR_11; pfam13414 991791009397 TPR repeat; Region: TPR_11; pfam13414 991791009398 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 991791009399 binding surface 991791009400 TPR motif; other site 991791009401 TPR repeat; Region: TPR_11; pfam13414 991791009402 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3877 991791009403 PucR C-terminal helix-turn-helix domain; Region: HTH_30; pfam13556 991791009404 Uncharacterized conserved protein [Function unknown]; Region: COG1633 991791009405 Ferritin-like superfamily of diiron-containing four-helix-bundle proteins; Region: Ferritin_like; cd00657 991791009406 dinuclear metal binding motif [ion binding]; other site 991791009407 thymidylate synthase; Reviewed; Region: thyA; PRK01827 991791009408 Thymidylate synthase and pyrimidine hydroxymethylase: Thymidylate synthase (TS) and deoxycytidylate hydroxymethylase (dCMP-HMase) are homologs that catalyze analogous alkylation of C5 of pyrimidine nucleotides. Both enzymes are involved in the...; Region: TS_Pyrimidine_HMase; cd00351 991791009409 dimerization interface [polypeptide binding]; other site 991791009410 active site 991791009411 Dihydrofolate reductase [Coenzyme metabolism]; Region: FolA; COG0262 991791009412 Dihydrofolate reductase (DHFR). Reduces 7,8-dihydrofolate to 5,6,7,8-tetrahydrofolate with NADPH as a cofactor. This is an essential step in the biosynthesis of deoxythymidine phosphate since 5,6,7,8-tetrahydrofolate is required to regenerate 5; Region: DHFR; cd00209 991791009413 folate binding site [chemical binding]; other site 991791009414 NADP+ binding site [chemical binding]; other site 991791009415 Adenosine deaminase [Nucleotide transport and metabolism]; Region: Add; COG1816 991791009416 Adenosine deaminase (ADA) is a monomeric zinc dependent enzyme which catalyzes the irreversible hydrolytic deamination of both adenosine, as well as desoxyadenosine, to ammonia and inosine or desoxyinosine, respectively. ADA plays an important role in...; Region: ADA; cd01320 991791009417 active site 991791009418 purine riboside binding site [chemical binding]; other site 991791009419 Predicted Zn-dependent peptidases, insulinase-like [General function prediction only]; Region: COG1026 991791009420 Insulinase (Peptidase family M16); Region: Peptidase_M16; pfam00675 991791009421 Peptidase M16 inactive domain; Region: Peptidase_M16_C; pfam05193 991791009422 Peptidase M16C associated; Region: M16C_assoc; pfam08367 991791009423 Peptidase M16 inactive domain; Region: Peptidase_M16_C; pfam05193 991791009424 ABC-type multidrug transport system, ATPase component [Defense mechanisms]; Region: CcmA; COG1131 991791009425 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 991791009426 ABC transporter; Region: ABC_tran_2; pfam12848 991791009427 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 991791009428 ABC-type cobalt transport system, ATPase component [Inorganic ion transport and metabolism]; Region: CbiO; COG1122 991791009429 FOG: CBS domain [General function prediction only]; Region: COG0517 991791009430 The CBS domain, named after human CBS, is a small domain originally identified in cystathionine beta-synthase and is subsequently found in a wide range of different proteins. CBS domains usually occur in tandem repeats. They associate to form a so-called...; Region: CBS_pair_30; cd04643 991791009431 Catalytic NodB homology domain of Bacillus subtilis polysaccharide deacetylase PdaA, and its bacterial homologs; Region: CE4_BsPdaA_like; cd10948 991791009432 delta-lactam-biosynthetic de-N-acetylase; Region: spore_pdaA; TIGR02884 991791009433 NodB motif; other site 991791009434 active site 991791009435 catalytic site [active] 991791009436 Cd binding site [ion binding]; other site 991791009437 Superfamily II DNA and RNA helicases [DNA replication, recombination, and repair / Transcription / Translation, ribosomal structure and biogenesis]; Region: SrmB; COG0513 991791009438 DEAD-box helicases. A diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker B motif; Region: DEADc; cd00268 991791009439 ATP binding site [chemical binding]; other site 991791009440 Mg++ binding site [ion binding]; other site 991791009441 motif III; other site 991791009442 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 991791009443 nucleotide binding region [chemical binding]; other site 991791009444 ATP-binding site [chemical binding]; other site 991791009445 RNA recognition motif in the DbpA subfamily of prokaryotic DEAD-box rRNA helicases; Region: RRM_DbpA; cd12252 991791009446 RNA binding site [nucleotide binding]; other site 991791009447 ATPase components of ABC transporters with duplicated ATPase domains [General function prediction only]; Region: Uup; COG0488 991791009448 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 991791009449 Walker A/P-loop; other site 991791009450 ATP binding site [chemical binding]; other site 991791009451 Q-loop/lid; other site 991791009452 ABC transporter signature motif; other site 991791009453 Walker B; other site 991791009454 D-loop; other site 991791009455 H-loop/switch region; other site 991791009456 ABC transporter; Region: ABC_tran_2; pfam12848 991791009457 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 991791009458 Uncharacterized conserved protein [Function unknown]; Region: COG5482 991791009459 thiamine biosynthesis protein ThiC; Provisional; Region: PRK13352 991791009460 thiamine biosynthesis protein ThiC; Region: thiC; TIGR00190 991791009461 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 991791009462 This family is most closely related to the GT1 family of glycosyltransferases and named after YqgM in Bacillus licheniformis about which little is known. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to...; Region: GT1_YqgM_like; cd03801 991791009463 Predicted integral membrane protein [Function unknown]; Region: COG0392 991791009464 Predicted xylanase/chitin deacetylase [Carbohydrate transport and metabolism]; Region: CDA1; COG0726 991791009465 Catalytic NodB homology domain of Streptococcus mutans polysaccharide deacetylase PgdA, Bacillus subtilis YheN, and similar proteins; Region: CE4_SmPgdA_like; cd10944 991791009466 NodB motif; other site 991791009467 active site 991791009468 catalytic site [active] 991791009469 Zn binding site [ion binding]; other site 991791009470 Rubrerythrin [Energy production and conversion]; Region: COG1592 991791009471 Rubrerythrin, ferritin-like diiron-binding domain; Region: Rubrerythrin; cd01041 991791009472 binuclear metal center [ion binding]; other site 991791009473 Rubredoxin, Small Modular nonheme iron binding domain containing a [Fe(SCys)4] center, present in rubrerythrin and nigerythrin and detected either N- or C-terminal to such proteins as flavin reductase, NAD(P)H-nitrite reductase, and...; Region: rubredoxin_SM; cd00729 991791009474 iron binding site [ion binding]; other site 991791009475 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 991791009476 metal binding site [ion binding]; metal-binding site 991791009477 active site 991791009478 I-site; other site 991791009479 EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2). The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948 991791009480 Ornithine acetyltransferase (OAT) family; also referred to as ArgJ. OAT catalyzes the first and fifth steps in arginine biosynthesis, coupling acetylation of glutamate with deacetylation of N-acetylornithine, which allows recycling of the acetyl group in...; Region: OAT; cd02152 991791009481 heterotetramer interface [polypeptide binding]; other site 991791009482 active site pocket [active] 991791009483 cleavage site 991791009484 Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067 991791009485 catalytic core [active] 991791009486 Alpha/beta hydrolase family; Region: Abhydrolase_5; pfam12695 991791009487 Members of the SGNH-hydrolase superfamily, a diverse family of lipases and esterases. The tertiary fold of the enzyme is substantially different from that of the alpha/beta hydrolase family and unique among all known hydrolases; its active site closely...; Region: SGNH_hydrolase_YpmR_like; cd04506 991791009488 active site 991791009489 catalytic triad [active] 991791009490 oxyanion hole [active] 991791009491 60Kd inner membrane protein; Region: 60KD_IMP; cl00489 991791009492 ABC-type transport system involved in multi-copper enzyme maturation, permease component [General function prediction only]; Region: NosY; COG1277 991791009493 ABC-2 family transporter protein; Region: ABC2_membrane_4; pfam12730 991791009494 ABC-type multidrug transport system, ATPase component [Defense mechanisms]; Region: CcmA; COG1131 991791009495 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 991791009496 Walker A/P-loop; other site 991791009497 ATP binding site [chemical binding]; other site 991791009498 Q-loop/lid; other site 991791009499 ABC transporter signature motif; other site 991791009500 Walker B; other site 991791009501 D-loop; other site 991791009502 H-loop/switch region; other site 991791009503 Bacillus subtilis YkuE and related proteins, C-terminal metallophosphatase domain; Region: MPP_YkuE_C; cd07385 991791009504 Calcineurin-like phosphoesterase; Region: Metallophos; pfam00149 991791009505 putative active site [active] 991791009506 putative metal binding site [ion binding]; other site 991791009507 CAAX protease self-immunity; Region: Abi; pfam02517 991791009508 Mannitol dehydrogenase C-terminal domain; Region: Mannitol_dh_C; pfam08125 991791009509 Polysaccharide pyruvyl transferase; Region: PS_pyruv_trans; pfam04230 991791009510 Histidinol-phosphate/aromatic aminotransferase and cobyric acid decarboxylase [Amino acid transport and metabolism]; Region: HisC; COG0079 991791009511 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 991791009512 pyridoxal 5'-phosphate binding site [chemical binding]; other site 991791009513 homodimer interface [polypeptide binding]; other site 991791009514 catalytic residue [active] 991791009515 Aldose 1-epimerase, similar to Lactococcus lactis lacX; Region: Aldose_epim_lacX; cd09024 991791009516 active site 991791009517 catalytic residues [active] 991791009518 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3883 991791009519 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3584 991791009520 Mismatch repair ATPase (MutS family) [DNA replication, recombination, and repair]; Region: MutS; COG0249 991791009521 MutS domain III; Region: MutS_III; pfam05192 991791009522 ATP-binding cassette domain of MutS-like homolog; Region: ABC_MutS-like; cd03283 991791009523 Walker A/P-loop; other site 991791009524 ATP binding site [chemical binding]; other site 991791009525 Q-loop/lid; other site 991791009526 ABC transporter signature motif; other site 991791009527 Walker B; other site 991791009528 D-loop; other site 991791009529 H-loop/switch region; other site 991791009530 Predicted hydrolases of the HAD superfamily [General function prediction only]; Region: Cof; COG0561 991791009531 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 991791009532 active site 991791009533 motif I; other site 991791009534 motif II; other site 991791009535 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 991791009536 Superfamily I DNA and RNA helicases and helicase subunits [DNA replication, recombination, and repair]; Region: COG1112 991791009537 The Fer4_NifH superfamily contains a variety of proteins which share a common ATP-binding domain. Functionally, proteins in this superfamily use the energy from hydrolysis of NTP to transfer electron or ion; Region: Fer4_NifH; cd01983 991791009538 AAA domain; Region: AAA_12; pfam13087 991791009539 Superfamily of nucleases including Short Patch Repair (Vsr) Endonucleases, archaeal Holliday junction resolvases, MutH methy-directed DNA mismatch-repair endonucleases, and catalytic domains of many restriction endonucleases, such as EcoRI, BamHI, and...; Region: Restriction_endonuclease_like; cl00277 991791009540 putative active site [active] 991791009541 Transcriptional regulators [Transcription]; Region: PurR; COG1609 991791009542 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 991791009543 DNA binding site [nucleotide binding] 991791009544 domain linker motif; other site 991791009545 Ligand binding domain of the LacI tanscriptional regulator family belonging to the type I periplasmic-binding fold protein superfamily; Region: PBP1_LacI_sugar_binding_like; cd06267 991791009546 dimerization interface [polypeptide binding]; other site 991791009547 ligand binding site [chemical binding]; other site 991791009548 isoleucyl-tRNA synthetase; Reviewed; Region: ileS; PRK06039 991791009549 catalytic core domain of isoleucyl-tRNA synthetases; Region: IleRS_core; cd00818 991791009550 HIGH motif; other site 991791009551 catalytic core domain of isoleucyl-tRNA synthetases; Region: IleRS_core; cd00818 991791009552 active site 991791009553 KMSKS motif; other site 991791009554 Anticodon-binding domain of archaeal, bacterial, and eukaryotic cytoplasmic isoleucyl tRNA synthetases; Region: Anticodon_Ia_Ile_ABEc; cd07961 991791009555 tRNA binding surface [nucleotide binding]; other site 991791009556 anticodon binding site; other site 991791009557 capsular exopolysaccharide family; Region: eps_fam; TIGR01007 991791009558 The Fer4_NifH superfamily contains a variety of proteins which share a common ATP-binding domain. Functionally, proteins in this superfamily use the energy from hydrolysis of NTP to transfer electron or ion; Region: Fer4_NifH; cl17203 991791009559 Fucose 4-O-acetylase and related acetyltransferases [Carbohydrate transport and metabolism]; Region: NolL; COG3594 991791009560 Acyltransferase family; Region: Acyl_transf_3; pfam01757 991791009561 Fucose 4-O-acetylase and related acetyltransferases [Carbohydrate transport and metabolism]; Region: NolL; COG3594 991791009562 Acyltransferase family; Region: Acyl_transf_3; pfam01757 991791009563 capsular exopolysaccharide family; Region: eps_fam; TIGR01007 991791009564 The Fer4_NifH superfamily contains a variety of proteins which share a common ATP-binding domain. Functionally, proteins in this superfamily use the energy from hydrolysis of NTP to transfer electron or ion; Region: Fer4_NifH; cl17203 991791009565 Chain length determinant protein; Region: Wzz; cl15801 991791009566 Capsular polysaccharide biosynthesis protein [Cell envelope biogenesis, outer membrane]; Region: COG3944 991791009567 Capsular polysaccharide biosynthesis protein [Carbohydrate transport and metabolism / Cell envelope biogenesis, outer membrane]; Region: CapC; COG4464 991791009568 Transcriptional regulator [Transcription]; Region: LytR; COG1316 991791009569 integral membrane protein MviN; Region: mviN; TIGR01695 991791009570 MurJ/MviN, a subfamily of the multidrug and toxic compound extrusion (MATE)-like proteins; Region: MATE_MurJ_like; cd13123 991791009571 O-Antigen ligase; Region: Wzy_C; pfam04932 991791009572 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 991791009573 This family is most closely related to the GT1 family of glycosyltransferases. wlbH in Bordetella parapertussis has been shown to be required for the biosynthesis of a trisaccharide that, when attached to the B. pertussis lipopolysaccharide (LPS) core; Region: GT1_wlbH_like; cd03798 991791009574 Polysaccharide pyruvyl transferase family protein [Cell wall/membrane/envelope biogenesis]; Region: WcaK; COG2327 991791009575 Polysaccharide pyruvyl transferase; Region: PS_pyruv_trans; cl09156 991791009576 sugar transferase, PEP-CTERM/EpsH1 system associated; Region: stp1; TIGR03087 991791009577 This family is most closely related to the GT1 family of glycosyltransferases and named after YqgM in Bacillus licheniformis about which little is known. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to...; Region: GT1_YqgM_like; cd03801 991791009578 This family is most closely related to the GT1 family of glycosyltransferases and named after YqgM in Bacillus licheniformis about which little is known. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to...; Region: GT1_YqgM_like; cd03801 991791009579 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 991791009580 Histidinol phosphatase and related phosphatases [Amino acid transport and metabolism]; Region: HisB; COG0241 991791009581 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 991791009582 active site 991791009583 motif I; other site 991791009584 motif II; other site 991791009585 Phosphoheptose isomerase is a member of the SIS (Sugar ISomerase) superfamily. Phosphoheptose isomerase catalyzes the isomerization of sedoheptulose 7-phosphate into D-glycero-D-mannoheptose 7-phosphate. This is the first step of the biosynthesis of...; Region: SIS_GmhA; cd05006 991791009586 active site 991791009587 dimer interface [polypeptide binding]; other site 991791009588 Predicted kinase related to galactokinase and mevalonate kinase [General function prediction only]; Region: COG2605 991791009589 GHMP kinases N terminal domain; Region: GHMP_kinases_N; pfam00288 991791009590 Nucleoside-diphosphate-sugar pyrophosphorylase involved in lipopolysaccharide biosynthesis/translation initiation factor 2B, gamma/epsilon subunits (eIF-2Bgamma/eIF-2Bepsilon) [Cell envelope biogenesis, outer membrane / Translation, ribosomal structure...; Region: GCD1; COG1208 991791009591 WcbM_like is a subfamily of nucleotidyl transferases; Region: NTP_transferase_WcbM_like; cd06915 991791009592 Substrate binding site; other site 991791009593 Mg++ binding site; other site 991791009594 metal-binding site 991791009595 Mg++ binding site; other site 991791009596 metal-binding site 991791009597 sugar transferase, PEP-CTERM/EpsH1 system associated; Region: stp1; TIGR03087 991791009598 This family is most closely related to the GT1 family of glycosyltransferases and named after YqgM in Bacillus licheniformis about which little is known. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to...; Region: GT1_YqgM_like; cd03801 991791009599 Mannose-1-phosphate guanylyltransferase [Cell envelope biogenesis, outer membrane]; Region: {ManC}; COG0836 991791009600 GDP-M1P_Guanylyltransferase catalyzes the formation of GDP-Mannose; Region: GDP-M1P_Guanylyltransferase; cd02509 991791009601 Substrate binding site; other site 991791009602 exopolysaccharide biosynthesis polyprenyl glycosylphosphotransferase; Region: EPS_sugtrans; TIGR03025 991791009603 Bacterial sugar transferase; Region: Bac_transf; pfam02397 991791009604 capsular exopolysaccharide family; Region: eps_fam; TIGR01007 991791009605 The Fer4_NifH superfamily contains a variety of proteins which share a common ATP-binding domain. Functionally, proteins in this superfamily use the energy from hydrolysis of NTP to transfer electron or ion; Region: Fer4_NifH; cl17203 991791009606 Chain length determinant protein; Region: Wzz; cl15801 991791009607 Capsular polysaccharide biosynthesis protein [Cell envelope biogenesis, outer membrane]; Region: COG3944 991791009608 Capsular polysaccharide biosynthesis protein [Carbohydrate transport and metabolism / Cell envelope biogenesis, outer membrane]; Region: CapC; COG4464 991791009609 Transcriptional regulator [Transcription]; Region: LytR; COG1316 991791009610 UDP-N-acetylglucosamine 2-epimerase [Cell envelope biogenesis, outer membrane]; Region: WecB; COG0381 991791009611 Bacterial members of the UDP-N-Acetylglucosamine (GlcNAc) 2-Epimerase family are known to catalyze the reversible interconversion of UDP-GlcNAc and UDP-N-acetylmannosamine (UDP-ManNAc). The enzyme serves to produce an activated form of ManNAc residues; Region: GT1_UDP-GlcNAc_2-Epimerase; cd03786 991791009612 active site 991791009613 homodimer interface [polypeptide binding]; other site 991791009614 Membrane protein involved in the export of O-antigen and teichoic acid [General function prediction only]; Region: RfbX; COG2244 991791009615 Wzx, a subfamily of the multidrug and toxic compound extrusion (MATE)-like proteins; Region: MATE_Wzx_like; cd13128 991791009616 Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: GT1_like_1; cd04950 991791009617 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 991791009618 putative homodimer interface [polypeptide binding]; other site 991791009619 O-Antigen ligase; Region: Wzy_C; pfam04932 991791009620 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 991791009621 Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013 991791009622 Predicted glycosyltransferases [General function prediction only]; Region: COG1216 991791009623 Subfamily of Glycosyltransferase Family GT2 of unknown function; Region: GT_2_like_c; cd04186 991791009624 Probable Catalytic site; other site 991791009625 metal-binding site 991791009626 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 991791009627 This family is most closely related to the GT1 family of glycosyltransferases. mtfB (mannosyltransferase B) in E. coli has been shown to direct the growth of the O9-specific polysaccharide chain. It transfers two mannoses into the position 3 of the...; Region: GT1_mtfB_like; cd03809 991791009628 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 991791009629 This family is most closely related to the GT1 family of glycosyltransferases. wbaZ in Salmonella enterica has been shown to possess the mannosyl transferase activity. The members of this family are found in certain bacteria and Archaea; Region: GT1_wbaZ_like; cd03804 991791009630 putative ADP-binding pocket [chemical binding]; other site 991791009631 Mannose-1-phosphate guanylyltransferase [Cell envelope biogenesis, outer membrane]; Region: {ManC}; COG0836 991791009632 GDP-M1P_Guanylyltransferase catalyzes the formation of GDP-Mannose; Region: GDP-M1P_Guanylyltransferase; cd02509 991791009633 Substrate binding site; other site 991791009634 exopolysaccharide biosynthesis polyprenyl glycosylphosphotransferase; Region: EPS_sugtrans; TIGR03025 991791009635 Bacterial sugar transferase; Region: Bac_transf; pfam02397 991791009636 Predicted integral membrane protein [Function unknown]; Region: COG5652 991791009637 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cd00012 991791009638 nucleotide binding site [chemical binding]; other site 991791009639 Acetokinase family; Region: Acetate_kinase; cl17229 991791009640 phosphate butyryltransferase; Validated; Region: PRK05805 991791009641 Uncharacterized FAD-dependent dehydrogenases [General function prediction only]; Region: COG2509 991791009642 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500 991791009643 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4856 991791009644 YbbR-like protein; Region: YbbR; pfam07949 991791009645 Uncharacterized conserved protein [Function unknown]; Region: COG1624 991791009646 DisA bacterial checkpoint controller nucleotide-binding; Region: DisA_N; pfam02457 991791009647 Cell wall hydrolyses involved in spore germination [Cell envelope biogenesis, outer membrane]; Region: SleB; COG3773 991791009648 Cell Wall Hydrolase; Region: Hydrolase_2; pfam07486 991791009649 Thioredoxin reductase [Posttranslational modification, protein turnover, chaperones]; Region: TrxB; COG0492 991791009650 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500 991791009651 TRX family; composed of two groups: Group I, which includes proteins that exclusively encode a TRX domain; and Group II, which are composed of fusion proteins of TRX and additional domains. Group I TRX is a small ancient protein that alter the redox...; Region: TRX_family; cd02947 991791009652 Thioredoxin-like; Region: Thioredoxin_8; pfam13905 991791009653 catalytic residues [active] 991791009654 tol-pal system protein YbgF; Region: tol_pal_ybgF; TIGR02795 991791009655 Bacterial surface proteins containing Ig-like domains [Cell motility and secretion]; Region: COG5492 991791009656 Bacterial Ig-like domain (group 2); Region: Big_2; pfam02368 991791009657 Bacterial surface proteins containing Ig-like domains [Cell motility and secretion]; Region: COG5492 991791009658 Protein Disulfide Oxidoreductases and Other Proteins with a Thioredoxin fold; Region: Thioredoxin_like; cl00388 991791009659 Bacterial Ig-like domain (group 2); Region: Big_2; pfam02368 991791009660 Bacterial Ig-like domain (group 2); Region: Big_2; pfam02368 991791009661 Phosphoenolpyruvate-protein kinase (PTS system EI component in bacteria) [Carbohydrate transport and metabolism]; Region: PtsA; COG1080 991791009662 PEP-utilising enzyme, N-terminal; Region: PEP-utilisers_N; pfam05524 991791009663 PEP-utilising enzyme, mobile domain; Region: PEP-utilizers; pfam00391 991791009664 PEP-utilising enzyme, TIM barrel domain; Region: PEP-utilizers_C; pfam02896 991791009665 Histidine-containing phosphocarrier protein (HPr)-like proteins. HPr is a central component of the bacterial phosphoenolpyruvate sugar phosphotransferase system (PTS). The PTS catalyses the phosphorylation of sugar substrates during their translocation...; Region: PTS-HPr_like; cd00367 991791009666 dimerization domain swap beta strand [polypeptide binding]; other site 991791009667 regulatory protein interface [polypeptide binding]; other site 991791009668 active site 991791009669 regulatory phosphorylation site [posttranslational modification]; other site 991791009670 Transcriptional regulator containing PAS, AAA-type ATPase, and DNA-binding domains [Transcription / Signal transduction mechanisms]; Region: RocR; COG3829 991791009671 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 991791009672 putative active site [active] 991791009673 heme pocket [chemical binding]; other site 991791009674 PAS domain; Region: PAS; smart00091 991791009675 putative active site [active] 991791009676 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 991791009677 Walker A motif; other site 991791009678 ATP binding site [chemical binding]; other site 991791009679 Walker B motif; other site 991791009680 arginine finger; other site 991791009681 fumarate hydratase; Provisional; Region: PRK06842 991791009682 fumarate hydratase; Provisional; Region: PRK06246 991791009683 N-acetylmuramoyl-L-alanine amidase [Cell envelope biogenesis, outer membrane]; Region: AmiC; COG0860 991791009684 N-acetylmuramoyl-L-alanine amidase or MurNAc-LAA (also known as peptidoglycan aminohydrolase, NAMLA amidase, NAMLAA, Amidase 3, and peptidoglycan amidase; EC 3.5.1.28) is an autolysin that hydrolyzes the amide bond between N-acetylmuramoyl and L-amino...; Region: MurNAc-LAA; cd02696 991791009685 active site 991791009686 metal binding site [ion binding]; metal-binding site 991791009687 Phosphate/sulphate permeases [Inorganic ion transport and metabolism]; Region: PitA; COG0306 991791009688 Phosphate transport regulator (distant homolog of PhoU) [Inorganic ion transport and metabolism]; Region: COG1392 991791009689 4-amino-5-hydroxymethyl-2-methyl-pyrimidine phosphate kinase (HMPP-kinase) catalyzes two consecutive phosphorylation steps in the thiamine phosphate biosynthesis pathway, leading to the synthesis of vitamin B1. The first step is the phosphorylation of...; Region: HMPP_kinase; cd01169 991791009690 dimer interface [polypeptide binding]; other site 991791009691 substrate binding site [chemical binding]; other site 991791009692 ATP binding site [chemical binding]; other site 991791009693 4-methyl-5-beta-hydroxyethylthiazole (Thz) kinase catalyzes the phosphorylation of the hydroxylgroup of Thz. A reaction that allows cells to recycle Thz into the thiamine biosynthesis pathway, as an alternative to its synthesis from cysteine, tyrosine...; Region: THZ_kinase; cd01170 991791009694 substrate binding site [chemical binding]; other site 991791009695 multimerization interface [polypeptide binding]; other site 991791009696 ATP binding site [chemical binding]; other site 991791009697 30S ribosomal protein S9; Reviewed; Region: rpsI; PRK00132 991791009698 Ribosomal protein L13. Protein L13, a large ribosomal subunit protein, is one of five proteins required for an early folding intermediate of 23S rRNA in the assembly of the large subunit. L13 is situated on the bottom of the large subunit, near the...; Region: Ribosomal_L13; cd00392 991791009699 23S rRNA interface [nucleotide binding]; other site 991791009700 L3 interface [polypeptide binding]; other site 991791009701 tRNA pseudouridine synthase A; Validated; Region: truA; PRK00021 991791009702 Eukaryotic and bacterial pseudouridine synthases similar to E. coli TruA; Region: PseudoU_synth_EcTruA; cd02570 991791009703 dimerization interface 3.5A [polypeptide binding]; other site 991791009704 active site 991791009705 ABC-type cobalt transport system, permease component CbiQ and related transporters [Inorganic ion transport and metabolism]; Region: CbiQ; COG0619 991791009706 cobalt transporter ATP-binding subunit; Provisional; Region: cbiO; PRK13637 991791009707 First domain of the ATP-binding cassette component of cobalt transport system; Region: ABC_cobalt_CbiO_domain1; cd03225 991791009708 Walker A/P-loop; other site 991791009709 ATP binding site [chemical binding]; other site 991791009710 Q-loop/lid; other site 991791009711 ABC transporter signature motif; other site 991791009712 Walker B; other site 991791009713 D-loop; other site 991791009714 H-loop/switch region; other site 991791009715 cobalt transporter ATP-binding subunit; Provisional; Region: PRK13633 991791009716 First domain of the ATP-binding cassette component of cobalt transport system; Region: ABC_cobalt_CbiO_domain1; cd03225 991791009717 Walker A/P-loop; other site 991791009718 ATP binding site [chemical binding]; other site 991791009719 Q-loop/lid; other site 991791009720 ABC transporter signature motif; other site 991791009721 Walker B; other site 991791009722 D-loop; other site 991791009723 H-loop/switch region; other site 991791009724 50S ribosomal protein L17; Validated; Region: rplQ; PRK05591 991791009725 DNA-directed RNA polymerase subunit alpha; Provisional; Region: PRK05182 991791009726 N-terminal domain of the Alpha subunit of Bacterial RNA polymerase; Region: RNAP_alpha_NTD; cd06928 991791009727 alphaNTD homodimer interface [polypeptide binding]; other site 991791009728 alphaNTD - beta interaction site [polypeptide binding]; other site 991791009729 alphaNTD - beta' interaction site [polypeptide binding]; other site 991791009730 Bacterial RNA polymerase, alpha chain C terminal domain; Region: RNA_pol_A_CTD; pfam03118 991791009731 30S ribosomal protein S4; Validated; Region: rpsD; PRK05327 991791009732 Ribosomal protein S4/S9 N-terminal domain; Region: Ribosomal_S4; pfam00163 991791009733 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 991791009734 RNA binding surface [nucleotide binding]; other site 991791009735 30S ribosomal protein S11; Validated; Region: PRK05309 991791009736 Ribosomal protein S13 [Translation, ribosomal structure and biogenesis]; Region: RpsM; COG0099 991791009737 30S ribosomal protein S13; Region: bact_S13; TIGR03631 991791009738 50S ribosomal protein L36; Reviewed; Region: rpmJ; PRK00465 991791009739 S1_IF1: Translation Initiation Factor IF1, S1-like RNA-binding domain. IF1 contains an S1-like RNA-binding domain, which is found in a wide variety of RNA-associated proteins. Translation initiation includes a number of interrelated steps preceding the...; Region: S1_IF1; cd04451 991791009740 rRNA binding site [nucleotide binding]; other site 991791009741 predicted 30S ribosome binding site; other site 991791009742 Ribosomal protein L14E/L6E/L27E [Translation, ribosomal structure and biogenesis]; Region: RPL14A; COG2163 991791009743 KOW motif of Ribosomal Protein L14; Region: KOW_RPL14; cd06088 991791009744 RNA binding site [nucleotide binding]; other site 991791009745 Methionine Aminopeptidase 1. E.C. 3.4.11.18. Also known as methionyl aminopeptidase and Peptidase M. Catalyzes release of N-terminal amino acids, preferentially methionine, from peptides and arylamides; Region: MetAP1; cd01086 991791009746 active site 991791009747 adenylate kinase; Reviewed; Region: adk; PRK00279 991791009748 Adenylate kinase (ADK) catalyzes the reversible phosphoryl transfer from adenosine triphosphates (ATP) to adenosine monophosphates (AMP) and to yield adenosine diphosphates (ADP). This enzyme is required for the biosynthesis of ADP and is essential for...; Region: ADK; cd01428 991791009749 AMP-binding site [chemical binding]; other site 991791009750 ATP-AMP (Ap5A)-binding site [chemical binding]; other site 991791009751 preprotein translocase subunit SecY; Reviewed; Region: secY; PRK09204 991791009752 SecY translocase; Region: SecY; pfam00344 991791009753 50S ribosomal protein L15; Reviewed; Region: rplO; PRK05592 991791009754 Ribosomal protein L30, which is found in eukaryotes and prokaryotes but not in archaea, is one of the smallest ribosomal proteins with a molecular mass of about 7kDa. L30 binds the 23SrRNA as well as the 5S rRNA and is one of five ribosomal proteins that...; Region: Ribosomal_L30; cd01658 991791009755 23S rRNA binding site [nucleotide binding]; other site 991791009756 30S ribosomal protein S5; Validated; Region: rpsE; PRK00550 991791009757 Ribosomal protein S5, N-terminal domain; Region: Ribosomal_S5; pfam00333 991791009758 Ribosomal protein S5, C-terminal domain; Region: Ribosomal_S5_C; pfam03719 991791009759 Ribosomal L18/L5e: L18 (L5e) is a ribosomal protein found in the central protuberance (CP) of the large subunit. L18 binds 5S rRNA and induces a conformational change that stimulates the binding of L5 to 5S rRNA. Association of 5S rRNA with 23S rRNA...; Region: Ribosomal_L18_L5e; cd00432 991791009760 5S rRNA interface [nucleotide binding]; other site 991791009761 L27 interface [polypeptide binding]; other site 991791009762 23S rRNA interface [nucleotide binding]; other site 991791009763 L5 interface [polypeptide binding]; other site 991791009764 50S ribosomal protein L6; Validated; Region: rplF; PRK05498 991791009765 Ribosomal protein L6; Region: Ribosomal_L6; pfam00347 991791009766 Ribosomal protein L6; Region: Ribosomal_L6; pfam00347 991791009767 30S ribosomal protein S8; Validated; Region: rpsH; PRK00136 991791009768 30S ribosomal protein S14; Reviewed; Region: rpsN; PRK08061 991791009769 50S ribosomal protein L5; Validated; Region: rplE; PRK00010 991791009770 Ribosomal protein L5; Region: Ribosomal_L5; pfam00281 991791009771 ribosomal L5P family C-terminus; Region: Ribosomal_L5_C; pfam00673 991791009772 50S ribosomal protein L24; Reviewed; Region: rplX; PRK00004 991791009773 KOW motif of Ribosomal Protein L26; Region: KOW_RPL26; cd06089 991791009774 RNA binding site [nucleotide binding]; other site 991791009775 50S ribosomal protein L14; Validated; Region: rplN; PRK05483 991791009776 30S ribosomal protein S17; Reviewed; Region: rpsQ; PRK05610 991791009777 Ribosomal L29 protein/HIP. L29 is a protein of the large ribosomal Subunit. A homolog, called heparin/heparan sulfate interacting protein (HIP), has also been identified in mammals. L29 is located on the surface of the large ribosomal subunit, where it...; Region: Ribosomal_L29_HIP; cd00427 991791009778 23S rRNA interface [nucleotide binding]; other site 991791009779 putative translocon interaction site; other site 991791009780 signal recognition particle (SRP54) interaction site; other site 991791009781 L23 interface [polypeptide binding]; other site 991791009782 trigger factor interaction site; other site 991791009783 Ribosomal_L16_L10e: L16 is an essential protein in the large ribosomal subunit of bacteria, mitochondria, and chloroplasts. Large subunits that lack L16 are defective in peptidyl transferase activity, peptidyl-tRNA hydrolysis activity, association with...; Region: Ribosomal_L16_L10e; cd01433 991791009784 23S rRNA interface [nucleotide binding]; other site 991791009785 5S rRNA interface [nucleotide binding]; other site 991791009786 putative antibiotic binding site [chemical binding]; other site 991791009787 L25 interface [polypeptide binding]; other site 991791009788 L27 interface [polypeptide binding]; other site 991791009789 30S ribosomal protein S3; Reviewed; Region: rpsC; PRK00310 991791009790 K homology RNA-binding (KH) domain of the prokaryotic 30S small ribosomal subunit protein S3. S3 is part of the head region of the 30S ribosomal subunit and is believed to interact with mRNA as it threads its way from the latch into the channel. The KH...; Region: 30S_S3_KH; cd02412 991791009791 G-X-X-G motif; other site 991791009792 Ribosomal protein S3, C-terminal domain; Region: Ribosomal_S3_C; pfam00189 991791009793 Ribosomal protein L22/L17e. L22 (L17 in eukaryotes) is a core protein of the large ribosomal subunit. It is the only ribosomal protein that interacts with all six domains of 23S rRNA, and is one of the proteins important for directing the proper...; Region: Ribosomal_L22; cd00336 991791009794 putative translocon binding site; other site 991791009795 protein-rRNA interface [nucleotide binding]; other site 991791009796 30S ribosomal protein S19; Reviewed; Region: rpsS; PRK00357 991791009797 50S ribosomal protein L2; Validated; Region: rplB; PRK09374 991791009798 Ribosomal Proteins L2, RNA binding domain; Region: Ribosomal_L2; pfam00181 991791009799 Ribosomal Proteins L2, C-terminal domain; Region: Ribosomal_L2_C; pfam03947 991791009800 50S ribosomal protein L23; Reviewed; Region: rplW; PRK05738 991791009801 50S ribosomal protein L4; Provisional; Region: rplD; PRK05319 991791009802 50S ribosomal protein L3; Validated; Region: rplC; PRK00001 991791009803 30S ribosomal protein S10; Reviewed; Region: rpsJ; PRK00596 991791009804 elongation factor Tu; Reviewed; Region: PRK00049 991791009805 Elongation Factor Tu (EF-Tu) GTP-binding proteins; Region: EF_Tu; cd01884 991791009806 G1 box; other site 991791009807 GEF interaction site [polypeptide binding]; other site 991791009808 GTP/Mg2+ binding site [chemical binding]; other site 991791009809 Switch I region; other site 991791009810 G2 box; other site 991791009811 G3 box; other site 991791009812 Switch II region; other site 991791009813 G4 box; other site 991791009814 G5 box; other site 991791009815 EFTU_II: Elongation factor Tu domain II. Elongation factors Tu (EF-Tu) are three-domain GTPases with an essential function in the elongation phase of mRNA translation. The GTPase center of EF-Tu is in the N-terminal domain (domain I), also known as the...; Region: EFTU_II; cd03697 991791009816 Domain III of elongation factor (EF) Tu. Ef-Tu consists of three structural domains, designated I, II and III. Domain III adopts a beta barrel structure. Domain III is involved in binding to both charged tRNA and binding to elongation factor Ts (EF-Ts); Region: EFTU_III; cd03707 991791009817 Antibiotic Binding Site [chemical binding]; other site 991791009818 elongation factor G; Reviewed; Region: PRK00007 991791009819 Elongation factor G (EF-G) family involved in both the elongation and ribosome recycling phases of protein synthesis; Region: EF-G; cd01886 991791009820 G1 box; other site 991791009821 putative GEF interaction site [polypeptide binding]; other site 991791009822 GTP/Mg2+ binding site [chemical binding]; other site 991791009823 Switch I region; other site 991791009824 G2 box; other site 991791009825 G3 box; other site 991791009826 Switch II region; other site 991791009827 G4 box; other site 991791009828 G5 box; other site 991791009829 EFG_mtEFG_II: this subfamily represents the domain II of elongation factor G (EF-G) in bacteria and, the C-terminus of mitochondrial Elongation factor G1 (mtEFG1) and G2 (mtEFG2)_like proteins found in eukaryotes. During the process of peptide synthesis...; Region: EFG_mtEFG_II; cd04088 991791009830 EFG_mtEFG1_IV: domains similar to domain IV of the bacterial translational elongation factor (EF) EF-G. Included in this group is a domain of mitochondrial Elongation factor G1 (mtEFG1) proteins homologous to domain IV of EF-G. Eukaryotic cells harbor 2...; Region: EFG_mtEFG1_IV; cd01434 991791009831 EFG_mtEFG_C: domains similar to the C-terminal domain of the bacterial translational elongation factor (EF) EF-G. Included in this group is the C-terminus of mitochondrial Elongation factor G1 (mtEFG1) and G2 (mtEFG2) proteins. Eukaryotic cells harbor 2...; Region: EFG_mtEFG_C; cd03713 991791009832 30S ribosomal protein S7; Validated; Region: PRK05302 991791009833 S12-like family, 30S ribosomal protein S12 subfamily; S12 is located at the interface of the large and small ribosomal subunits of prokaryotes, chloroplasts and mitochondria, where it plays an important role in both tRNA and ribosomal subunit...; Region: Ribosomal_S12; cd03368 991791009834 S17 interaction site [polypeptide binding]; other site 991791009835 S8 interaction site; other site 991791009836 16S rRNA interaction site [nucleotide binding]; other site 991791009837 streptomycin interaction site [chemical binding]; other site 991791009838 23S rRNA interaction site [nucleotide binding]; other site 991791009839 aminoacyl-tRNA interaction site (A-site) [nucleotide binding]; other site 991791009840 Ribosomal protein L7Ae/L30e/S12e/Gadd45 family; Region: Ribosomal_L7Ae; cl00600 991791009841 RNA polymerase Rpb1, domain 1; Region: RNA_pol_Rpb1_1; pfam04997 991791009842 DNA-directed RNA polymerase subunit beta'; Provisional; Region: PRK00566 991791009843 RNA polymerase I subunit A N-terminus; Region: RPOLA_N; smart00663 991791009844 RNA polymerase Rpb1, domain 3; Region: RNA_pol_Rpb1_3; pfam04983 991791009845 RNA polymerase Rpb1, domain 4; Region: RNA_pol_Rpb1_4; pfam05000 991791009846 Largest subunit (beta') of Bacterial DNA-dependent RNA polymerase (RNAP), C-terminal domain; Region: RNAP_beta'_C; cd02655 991791009847 Rpb1 (beta') - Rpb6 (omega) interaction site [polypeptide binding]; other site 991791009848 Rpb1 (beta') - Rpb2 (beta) interaction site [polypeptide binding]; other site 991791009849 G-loop; other site 991791009850 DNA binding site [nucleotide binding] 991791009851 DNA-directed RNA polymerase subunit beta; Reviewed; Region: rpoB; PRK00405 991791009852 RNA polymerase beta subunit. RNA polymerases catalyse the DNA dependent polymerization of RNA. Prokaryotes contain a single RNA polymerase compared to three in eukaryotes (not including mitochondrial. and chloroplast polymerases). Each RNA polymerase...; Region: RNA_pol_B_RPB2; cl17585 991791009853 RNA polymerase Rpb2, domain 2; Region: RNA_pol_Rpb2_2; pfam04561 991791009854 RNA polymerase beta subunit. RNA polymerases catalyse the DNA dependent polymerization of RNA. Prokaryotes contain a single RNA polymerase compared to three in eukaryotes (not including mitochondrial. and chloroplast polymerases). Each RNA polymerase...; Region: RNA_pol_B_RPB2; cd00653 991791009855 RPB1 interaction site [polypeptide binding]; other site 991791009856 RPB10 interaction site [polypeptide binding]; other site 991791009857 RPB11 interaction site [polypeptide binding]; other site 991791009858 RPB3 interaction site [polypeptide binding]; other site 991791009859 RPB12 interaction site [polypeptide binding]; other site 991791009860 Ribosomal protein L7/L12. Ribosomal protein L7/L12 refers to the large ribosomal subunit proteins L7 and L12, which are identical except that L7 is acetylated at the N terminus. It is a component of the L7/L12 stalk, which is located at the surface of...; Region: Ribosomal_L7_L12; cd00387 991791009861 core dimer interface [polypeptide binding]; other site 991791009862 peripheral dimer interface [polypeptide binding]; other site 991791009863 L10 interface [polypeptide binding]; other site 991791009864 L11 interface [polypeptide binding]; other site 991791009865 putative EF-Tu interaction site [polypeptide binding]; other site 991791009866 putative EF-G interaction site [polypeptide binding]; other site 991791009867 Ribosomal protein L10 family, L10 subfamily; composed of bacterial 50S ribosomal protein and eukaryotic mitochondrial 39S ribosomal protein, L10. L10 occupies the L7/L12 stalk of the ribosome. The N-terminal domain (NTD) of L10 interacts with L11 protein...; Region: Ribosomal_L10; cd05797 991791009868 23S rRNA interface [nucleotide binding]; other site 991791009869 Interface with L7/L12 ribosomal proteins [polypeptide binding]; other site 991791009870 Ribosomal protein L1. The L1 protein, located near the E-site of the ribosome, forms part of the L1 stalk along with 23S rRNA. In bacteria and archaea, L1 functions both as a ribosomal protein that binds rRNA, and as a translation repressor that binds...; Region: Ribosomal_L1; cd00403 991791009871 mRNA/rRNA interface [nucleotide binding]; other site 991791009872 50S ribosomal protein L11; Validated; Region: rplK; PRK00140 991791009873 Ribosomal protein L11. Ribosomal protein L11, together with proteins L10 and L7/L12, and 23S rRNA, form the L7/L12 stalk on the surface of the large subunit of the ribosome. The homologous eukaryotic cytoplasmic protein is also called 60S ribosomal...; Region: Ribosomal_L11; cd00349 991791009874 23S rRNA interface [nucleotide binding]; other site 991791009875 L7/L12 interface [polypeptide binding]; other site 991791009876 putative thiostrepton binding site; other site 991791009877 L25 interface [polypeptide binding]; other site 991791009878 transcription antitermination protein NusG; Validated; Region: nusG; PRK05609 991791009879 Bacterial N-Utilization Substance G (NusG) N-terminal (NGN) domain, subgroup 1; Region: NGN_Bact_1; cd09891 991791009880 putative homodimer interface [polypeptide binding]; other site 991791009881 NusG contains an NGN domain at its N-terminus and KOW motif at its C-terminus; Region: KOW_NusG; cd06091 991791009882 heterodimer interface [polypeptide binding]; other site 991791009883 homodimer interface [polypeptide binding]; other site 991791009884 Preprotein translocase subunit SecE [Intracellular trafficking and secretion]; Region: SecE; COG0690 991791009885 50S ribosomal protein L33; Validated; Region: rpmG; PRK00504 991791009886 elongation factor Tu; Reviewed; Region: PRK00049 991791009887 Elongation Factor Tu (EF-Tu) GTP-binding proteins; Region: EF_Tu; cd01884 991791009888 G1 box; other site 991791009889 GEF interaction site [polypeptide binding]; other site 991791009890 GTP/Mg2+ binding site [chemical binding]; other site 991791009891 Switch I region; other site 991791009892 G2 box; other site 991791009893 G3 box; other site 991791009894 Switch II region; other site 991791009895 G4 box; other site 991791009896 G5 box; other site 991791009897 EFTU_II: Elongation factor Tu domain II. Elongation factors Tu (EF-Tu) are three-domain GTPases with an essential function in the elongation phase of mRNA translation. The GTPase center of EF-Tu is in the N-terminal domain (domain I), also known as the...; Region: EFTU_II; cd03697 991791009898 Domain III of elongation factor (EF) Tu. Ef-Tu consists of three structural domains, designated I, II and III. Domain III adopts a beta barrel structure. Domain III is involved in binding to both charged tRNA and binding to elongation factor Ts (EF-Ts); Region: EFTU_III; cd03707 991791009899 Antibiotic Binding Site [chemical binding]; other site 991791009900 RNA polymerase factor sigma-70; Validated; Region: PRK08295 991791009901 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 991791009902 helix_turn_helix, Lux Regulon; Region: HTH_LUXR; smart00421 991791009903 DNA binding residues [nucleotide binding] 991791009904 Predicted RNA-binding protein containing a PIN domain [General function prediction only]; Region: COG3688 991791009905 rRNA methylases [Translation, ribosomal structure and biogenesis]; Region: SpoU; COG0566 991791009906 RNA 2'-O ribose methyltransferase substrate binding; Region: SpoU_sub_bind; pfam08032 991791009907 SpoU rRNA Methylase family; Region: SpoU_methylase; pfam00588 991791009908 Predicted alternative thymidylate synthase [Nucleotide transport and metabolism]; Region: THY1; COG1351 991791009909 RIBOc. Ribonuclease III C terminal domain. This group consists of eukaryotic, bacterial and archeal ribonuclease III (RNAse III) proteins. RNAse III is a double stranded RNA-specific endonuclease. Prokaryotic RNAse III is important in...; Region: RIBOc; cd00593 991791009910 active site 991791009911 metal binding site [ion binding]; metal-binding site 991791009912 dimerization interface [polypeptide binding]; other site 991791009913 tryptophan synthase alpha subunit; Provisional; Region: trpA; CHL00200 991791009914 Ttryptophan synthase (TRPS) alpha subunit (TSA). TPRS is a bifunctional tetrameric enzyme (2 alpha and 2 beta subunits) that catalyzes the last two steps of L-tryptophan biosynthesis. Alpha and beta subunit catalyze two distinct reactions which are both...; Region: Tryptophan_synthase_alpha; cd04724 991791009915 substrate binding site [chemical binding]; other site 991791009916 active site 991791009917 catalytic residues [active] 991791009918 heterodimer interface [polypeptide binding]; other site 991791009919 tryptophan synthase, beta subunit; Region: trpB; TIGR00263 991791009920 Tryptophan synthase-beta: Trptophan synthase is a bifunctional enzyme that catalyses the last two steps in the biosynthesis of L-tryptophan via its alpha and beta reactions. In the alpha reaction, indole 3-glycerol phosphate is cleaved reversibly to...; Region: Trp-synth_B; cd06446 991791009921 pyridoxal 5'-phosphate binding site [chemical binding]; other site 991791009922 catalytic residue [active] 991791009923 Phosphoribosylanthranilate isomerase (PRAI) catalyzes the fourth step of the tryptophan biosynthesis, the conversion of N-(5'- phosphoribosyl)-anthranilate (PRA) to 1-(o-carboxyphenylamino)- 1-deoxyribulose 5-phosphate (CdRP). Most PRAIs are...; Region: PRAI; cd00405 991791009924 active site 991791009925 Indole-3-glycerol phosphate synthase (IGPS); an enzyme in the tryptophan biosynthetic pathway, catalyzing the ring closure reaction of 1-(o-carboxyphenylamino)-1-deoxyribulose-5-phosphate (CdRP) to indole-3-glycerol phosphate (IGP), accompanied by the...; Region: IGPS; cd00331 991791009926 active site 991791009927 ribulose/triose binding site [chemical binding]; other site 991791009928 phosphate binding site [ion binding]; other site 991791009929 substrate (anthranilate) binding pocket [chemical binding]; other site 991791009930 product (indole) binding pocket [chemical binding]; other site 991791009931 anthranilate phosphoribosyltransferase; Provisional; Region: trpD; PRK00188 991791009932 Glycosyl transferase family, helical bundle domain; Region: Glycos_trans_3N; pfam02885 991791009933 Glycosyl transferase family, a/b domain; Region: Glycos_transf_3; pfam00591 991791009934 para-aminobenzoate synthase component II; Provisional; Region: PRK08857 991791009935 Type 1 glutamine amidotransferase (GATase1) domain found in Anthranilate synthase; Region: GATase1_Anthranilate_Synthase; cd01743 991791009936 glutamine binding [chemical binding]; other site 991791009937 catalytic triad [active] 991791009938 anthranilate synthase component I; Provisional; Region: PRK13570 991791009939 Anthranilate synthase component I, N terminal region; Region: Anth_synt_I_N; pfam04715 991791009940 chorismate binding enzyme; Region: Chorismate_bind; pfam00425 991791009941 lysine transporter; Provisional; Region: PRK10836 991791009942 Predicted DNA-binding proteins [General function prediction only]; Region: COG1342 991791009943 This uncharacterized conserved protein belongs to a family of iron-molybdenum cluster-binding proteins that includes NifX, NifB, and NifY, all of which are involved in the synthesis of an iron-molybdenum cofactor (FeMo-co) that binds the active site of...; Region: MTH1175; cd00851 991791009944 acetolactate synthase 3 catalytic subunit; Reviewed; Region: PRK06048 991791009945 Pyrimidine (PYR) binding domain of POX and related proteins; Region: TPP_PYR_POX_like; cd07035 991791009946 PYR/PP interface [polypeptide binding]; other site 991791009947 dimer interface [polypeptide binding]; other site 991791009948 TPP binding site [chemical binding]; other site 991791009949 Thiamine pyrophosphate enzyme, central domain; Region: TPP_enzyme_M; pfam00205 991791009950 Thiamine pyrophosphate (TPP) family, Acetohydroxyacid synthase (AHAS) subfamily, TPP-binding module; composed of proteins similar to the large catalytic subunit of AHAS. AHAS catalyzes the condensation of two molecules of pyruvate to give the...; Region: TPP_AHAS; cd02015 991791009951 TPP-binding site [chemical binding]; other site 991791009952 dimer interface [polypeptide binding]; other site 991791009953 dihydroxy-acid dehydratase; Provisional; Region: PRK00911 991791009954 tartrate dehydrogenase; Provisional; Region: PRK08194 991791009955 3-isopropylmalate dehydrogenase; Provisional; Region: PRK00772 991791009956 3-isopropylmalate dehydratase, small subunit; Region: leud; TIGR02084 991791009957 Aconatase-like swivel domain of 3-isopropylmalate dehydratase and related uncharacterized proteins. 3-isopropylmalate dehydratase catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate...; Region: IPMI_Swivel; cd01577 991791009958 substrate binding site [chemical binding]; other site 991791009959 3-isopropylmalate dehydratase large subunit; Reviewed; Region: PRK00402 991791009960 3-isopropylmalate dehydratase catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate; Region: IPMI; cd01583 991791009961 substrate binding site [chemical binding]; other site 991791009962 ligand binding site [chemical binding]; other site 991791009963 putative alpha-isopropylmalate/homocitrate synthase family transferase; Provisional; Region: PRK12344 991791009964 Desulfobacterium autotrophicum LeuA3 and related proteins, N-terminal catalytic TIM barrel domain; Region: DRE_TIM_LeuA3; cd07941 991791009965 active site 991791009966 catalytic residues [active] 991791009967 metal binding site [ion binding]; metal-binding site 991791009968 Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 residue sequence motifs present in many proteins that participate in protein-protein interactions and have different functions and cellular locations. LRRs correspond...; Region: LRR_RI; cl15309 991791009969 LeuA allosteric (dimerisation) domain; Region: LeuA_dimer; smart00917 991791009970 N-terminal ACT domain of the Escherichia coli IlvH-like regulatory subunit of acetohydroxyacid synthase (AHAS); Region: ACT_AHAS; cd04878 991791009971 acetolactate synthase 3 regulatory subunit; Reviewed; Region: ilvH; PRK11895 991791009972 putative valine binding site [chemical binding]; other site 991791009973 dimer interface [polypeptide binding]; other site 991791009974 Small subunit of acetolactate synthase; Region: ALS_ss_C; pfam10369 991791009975 cysteinyl-tRNA synthetase; Validated; Region: cysS; PRK00260 991791009976 catalytic core domain of cysteinyl tRNA synthetase; Region: CysRS_core; cd00672 991791009977 active site 991791009978 HIGH motif; other site 991791009979 catalytic core domain of cysteinyl tRNA synthetase; Region: CysRS_core; cd00672 991791009980 KMSKS motif; other site 991791009981 Anticodon-binding domain of cysteinyl tRNA synthetases; Region: Anticodon_Ia_Cys; cd07963 991791009982 tRNA binding surface [nucleotide binding]; other site 991791009983 anticodon binding site; other site 991791009984 prolyl-tRNA synthetase; Provisional; Region: PRK09194 991791009985 Prolyl-tRNA synthetase (ProRS) class II core catalytic domain. ProRS is a homodimer. It is responsible for the attachment of proline to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for ATP-dependent...; Region: ProRS_core_prok; cd00779 991791009986 dimer interface [polypeptide binding]; other site 991791009987 motif 1; other site 991791009988 active site 991791009989 motif 2; other site 991791009990 INS is an amino acid-editing domain inserted (INS) into the bacterial class II prolyl-tRNA synthetase (ProRS) however, this CD is not exclusively bacterial. It is also found at the N-terminus of the eukaryotic/archaea-like ProRS's of yeasts and...; Region: ProRS-INS; cd04334 991791009991 putative deacylase active site [active] 991791009992 Class II tRNA amino-acyl synthetase-like catalytic core domain. Class II amino acyl-tRNA synthetases (aaRS) share a common fold and generally attach an amino acid to the 3' OH of ribose of the appropriate tRNA. PheRS is an exception in that it...; Region: class_II_aaRS-like_core; cl00268 991791009993 active site 991791009994 motif 3; other site 991791009995 ProRS Prolyl-anticodon binding domain, short version found predominantly in bacteria. ProRS belongs to class II aminoacyl-tRNA synthetases (aaRS). This alignment contains the anticodon binding domain, which is responsible for specificity in tRNA-binding; Region: ProRS_anticodon_short; cd00861 991791009996 anticodon binding site; other site 991791009997 ABC-type dipeptide transport system, periplasmic component [Amino acid transport and metabolism]; Region: DdpA; COG0747 991791009998 The substrate-binding domain of an ABC-type nickel/oligopeptide-like import system contains the type 2 periplasmic binding fold; Region: PBP2_NikA_DppA_OppA_like; cd00995 991791009999 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppB; COG0601 991791010000 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 991791010001 dimer interface [polypeptide binding]; other site 991791010002 conserved gate region; other site 991791010003 putative PBP binding loops; other site 991791010004 ABC-ATPase subunit interface; other site 991791010005 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppC; COG1173 991791010006 N-terminal TM domain of oligopeptide transport permease C; Region: OppC_N; pfam12911 991791010007 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 991791010008 putative PBP binding loops; other site 991791010009 dimer interface [polypeptide binding]; other site 991791010010 ABC-ATPase subunit interface; other site 991791010011 ABC-type dipeptide/oligopeptide/nickel transport system, ATPase component [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppD; COG0444 991791010012 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 991791010013 Walker A/P-loop; other site 991791010014 ATP binding site [chemical binding]; other site 991791010015 Q-loop/lid; other site 991791010016 ABC transporter signature motif; other site 991791010017 Walker B; other site 991791010018 D-loop; other site 991791010019 H-loop/switch region; other site 991791010020 oligopeptide/dipeptide ABC transporter, ATP-binding protein, C-terminal domain; Region: oligo_HPY; TIGR01727 991791010021 ABC-type oligopeptide transport system, ATPase component [Amino acid transport and metabolism]; Region: AppF; COG4608 991791010022 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 991791010023 Walker A/P-loop; other site 991791010024 ATP binding site [chemical binding]; other site 991791010025 Q-loop/lid; other site 991791010026 ABC transporter signature motif; other site 991791010027 Walker B; other site 991791010028 D-loop; other site 991791010029 H-loop/switch region; other site 991791010030 oligopeptide/dipeptide ABC transporter, ATP-binding protein, C-terminal domain; Region: oligo_HPY; TIGR01727 991791010031 CDP-ME synthetase is involved in mevalonate-independent isoprenoid production; Region: CDP-ME_synthetase; cd02516 991791010032 substrate binding site; other site 991791010033 dimer interface; other site 991791010034 Integral membrane protein (PIN domain superfamily) [General function prediction only]; Region: COG4956 991791010035 PIN domain of Thermus Thermophilus Hb8, uncharacterized Bacillus subtilis YacL, and other bacterial homologs; Region: PIN_YacL; cd09877 991791010036 putative active site [active] 991791010037 TRAM domain; Region: TRAM; cl01282 991791010038 Nucleoside Triphosphate Pyrophosphohydrolase (EC 3.6.1.8) MazG-like domain superfamily; Region: NTP-PPase; cl16941 991791010039 DNA integrity scanning protein DisA; Provisional; Region: PRK13482 991791010040 DisA bacterial checkpoint controller nucleotide-binding; Region: DisA_N; pfam02457 991791010041 DisA bacterial checkpoint controller linker region; Region: DisA-linker; pfam10635 991791010042 Helix-hairpin-helix motif; Region: HHH; pfam00633 991791010043 DNA repair protein RadA; Provisional; Region: PRK11823 991791010044 Sms (bacterial radA) DNA repair protein. This protein is not related to archael radA any more than is to other RecA-like NTPases. Sms has a role in recombination and recombinational repair and is responsible for the stabilization or processing of...; Region: Sms; cd01121 991791010045 Walker A motif/ATP binding site; other site 991791010046 ATP binding site [chemical binding]; other site 991791010047 Walker B motif; other site 991791010048 Subunit ChlI of Mg-chelatase; Region: ChlI; pfam13541 991791010049 ATP-binding subunits of Clp protease and DnaK/DnaJ chaperones [Posttranslational modification, protein turnover, chaperones]; Region: clpA; COG0542 991791010050 Clp amino terminal domain; Region: Clp_N; pfam02861 991791010051 Clp amino terminal domain; Region: Clp_N; pfam02861 991791010052 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 991791010053 Walker A motif; other site 991791010054 ATP binding site [chemical binding]; other site 991791010055 Walker B motif; other site 991791010056 arginine finger; other site 991791010057 UvrB/uvrC motif; Region: UVR; pfam02151 991791010058 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 991791010059 Walker A motif; other site 991791010060 ATP binding site [chemical binding]; other site 991791010061 Walker B motif; other site 991791010062 C-terminal, D2-small domain, of ClpB protein; Region: ClpB_D2-small; pfam10431 991791010063 ATP:guanido phosphotransferase; Provisional; Region: PRK01059 991791010064 Phosphagen (guanidino) kinases found in bacteria; Region: bacterial_phosphagen_kinase; cd07930 991791010065 ADP binding site [chemical binding]; other site 991791010066 phosphagen binding site; other site 991791010067 substrate specificity loop; other site 991791010068 Modulator of heat shock repressor CtsR, McsA [Signal transduction mechanisms]; Region: COG3880 991791010069 UvrB/uvrC motif; Region: UVR; pfam02151 991791010070 Transcriptional repressor of class III stress genes [Transcription]; Region: CtsR; COG4463 991791010071 UDP-N-acetylmuramoyl-L-alanyl-D-glutamate synthetase; Provisional; Region: murD; PRK01710 991791010072 Mur ligase middle domain; Region: Mur_ligase_M; pfam08245 991791010073 glycyl-tRNA synthetase; Provisional; Region: PRK04173 991791010074 Class II tRNA amino-acyl synthetase-like catalytic core domain. Class II amino acyl-tRNA synthetases (aaRS) share a common fold and generally attach an amino acid to the 3' OH of ribose of the appropriate tRNA. PheRS is an exception in that it...; Region: class_II_aaRS-like_core; cl00268 991791010075 motif 1; other site 991791010076 Glycyl-tRNA synthetase (GlyRS)-like class II core catalytic domain. GlyRS functions as a homodimer in eukaryotes, archaea and some bacteria and as a heterotetramer in the remainder of prokaryotes. It is responsible for the attachment of glycine to the 3...; Region: GlyRS-like_core; cd00774 991791010077 active site 991791010078 motif 2; other site 991791010079 motif 3; other site 991791010080 GlyRS Glycyl-anticodon binding domain. GlyRS belongs to class II aminoacyl-tRNA synthetases (aaRS). This alignment contains the anticodon binding domain, which is responsible for specificity in tRNA-binding, so that the activated amino acid is...; Region: GlyRS_anticodon; cd00858 991791010081 anticodon binding site; other site 991791010082 lysyl-tRNA synthetase; Reviewed; Region: lysS; PRK00484 991791010083 LysRS_N: N-terminal, anticodon recognition domain of lysyl-tRNA synthetases (LysRS). These enzymes are homodimeric class 2b aminoacyl-tRNA synthetases (aaRSs). This domain is a beta-barrel domain (OB fold) involved in binding the tRNA anticodon stem-loop; Region: LysRS_N; cd04322 991791010084 dimer interface [polypeptide binding]; other site 991791010085 putative anticodon binding site; other site 991791010086 Lys_tRNA synthetase (LysRS) class II core domain. Class II LysRS is a dimer which attaches a lysine to the 3' OH group of ribose of the appropriate tRNA. Its assignment to class II aaRS is based upon its structure and the presence of three...; Region: LysRS_core; cd00775 991791010087 motif 1; other site 991791010088 active site 991791010089 motif 2; other site 991791010090 motif 3; other site 991791010091 transcription elongation factor GreA; Reviewed; Region: greA; PRK00226 991791010092 Transcription elongation factor, N-terminal; Region: GreA_GreB_N; pfam03449 991791010093 Transcription elongation factor, GreA/GreB, C-term; Region: GreA_GreB; pfam01272 991791010094 putative TIM-barrel protein, nifR3 family; Region: nifR3_yhdG; TIGR00737 991791010095 Dihydrouridine synthase-like (DUS-like) FMN-binding domain. Members of this family catalyze the reduction of the 5,6-double bond of a uridine residue on tRNA. Dihydrouridine modification of tRNA is widely observed in prokaryotes and eukaryotes, and also...; Region: DUS_like_FMN; cd02801 991791010096 FMN binding site [chemical binding]; other site 991791010097 active site 991791010098 catalytic residues [active] 991791010099 substrate binding site [chemical binding]; other site 991791010100 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cd00012 991791010101 nucleotide binding site [chemical binding]; other site 991791010102 formate--tetrahydrofolate ligase; Provisional; Region: PRK13505 991791010103 Formyltetrahydrofolate synthetase (FTHFS) catalyzes the ATP-dependent activation of formate ion via its addition to the N10 position of tetrahydrofolate. FTHFS is a highly expressed key enzyme in both the Wood-Ljungdahl pathway of autotrophic CO2...; Region: FTHFS; cd00477 991791010104 Potassium binding sites [ion binding]; other site 991791010105 Cesium cation binding sites [ion binding]; other site 991791010106 ATP-dependent Zn proteases [Posttranslational modification, protein turnover, chaperones]; Region: HflB; COG0465 991791010107 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 991791010108 Walker A motif; other site 991791010109 ATP binding site [chemical binding]; other site 991791010110 Walker B motif; other site 991791010111 arginine finger; other site 991791010112 Peptidase family M41; Region: Peptidase_M41; pfam01434 991791010113 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 991791010114 active site 991791010115 tRNA(Ile)-lysidine synthase MesJ [Cell cycle control, cell division, chromosome partitioning]; Region: MesJ; COG0037 991791010116 N-terminal domain of predicted ATPase of the PP-loop faimly implicated in cell cycle control [Cell division and chromosome partitioning]. This is a subfamily of Adenine nucleotide alpha hydrolases superfamily.Adeninosine nucleotide alpha hydrolases...; Region: PP-ATPase; cd01992 991791010117 Ligand Binding Site [chemical binding]; other site 991791010118 TilS substrate C-terminal domain; Region: TilS_C; smart00977 991791010119 stage II sporulation protein E; Region: spore_II_E; TIGR02865 991791010120 Stage II sporulation protein E (SpoIIE); Region: SpoIIE; pfam07228 991791010121 hypothetical protein; Provisional; Region: PRK05807 991791010122 S1_like: Ribosomal protein S1-like RNA-binding domain. Found in a wide variety of RNA-associated proteins. Originally identified in S1 ribosomal protein. This superfamily also contains the Cold Shock Domain (CSD), which is a homolog of the S1 domain; Region: S1_like; cl09927 991791010123 RNA binding site [nucleotide binding]; other site 991791010124 Septum formation initiator; Region: DivIC; pfam04977 991791010125 spore cortex biosynthesis protein YabQ; Region: spore_yabQ; TIGR02893 991791010126 sporulation protein YabP; Region: spore_yabP; TIGR02892 991791010127 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 991791010128 RNA binding surface [nucleotide binding]; other site 991791010129 Integration host factor (IHF) and HU are small heterodimeric members of the DNABII protein family that bind and bend DNA, functioning as architectural factors in many cellular processes including transcription, site-specific recombination, and...; Region: HU_IHF; cd00591 991791010130 IHF dimer interface [polypeptide binding]; other site 991791010131 IHF - DNA interface [nucleotide binding]; other site 991791010132 Protein containing tetrapyrrole methyltransferase domain and MazG-like (predicted pyrophosphatase) domain [General function prediction only]; Region: COG3956 991791010133 N-terminal S-AdoMet dependent methylase domain of Bacillus subtilis YabN and related proteins; Region: YabN_N; cd11723 991791010134 putative SAM binding site [chemical binding]; other site 991791010135 putative homodimer interface [polypeptide binding]; other site 991791010136 Nucleoside Triphosphate Pyrophosphohydrolase (EC 3.6.1.8) N-terminal tandem-domain of MazG proteins from Escherichia coli and bacterial homologs; Region: NTP-PPase_MazG_Nterm; cd11528 991791010137 homodimer interface [polypeptide binding]; other site 991791010138 metal binding site [ion binding]; metal-binding site 991791010139 Nucleoside Triphosphate Pyrophosphohydrolase (EC 3.6.1.8) C-terminal tandem-domain of MazG proteins from Escherichia coli and bacterial homologs' Region: NTP-PPase_MazG_Cterm; cd11529 991791010140 homodimer interface [polypeptide binding]; other site 991791010141 active site 991791010142 putative chemical substrate binding site [chemical binding]; other site 991791010143 metal binding site [ion binding]; metal-binding site 991791010144 Stage V sporulation protein B, also known as Stage III sporulation protein F, and related proteins; Region: MATE_SpoVB_like; cd13124 991791010145 stage V sporulation protein B; Region: spore_V_B; TIGR02900 991791010146 stage V sporulation protein T; Region: spore_V_T; TIGR02851 991791010147 looped-hinge helix DNA binding domain, AbrB family; Region: lp_hng_hel_AbrB; TIGR01439 991791010148 peptidylprolyl isomerase; Provisional; Region: prsA; PRK00059 991791010149 PPIC-type PPIASE domain; Region: Rotamase; pfam00639 991791010150 Transcription-repair coupling factor (superfamily II helicase) [DNA replication, recombination, and repair / Transcription]; Region: Mfd; COG1197 991791010151 CarD-like/TRCF domain; Region: CarD_TRCF; smart01058 991791010152 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 991791010153 ATP binding site [chemical binding]; other site 991791010154 putative Mg++ binding site [ion binding]; other site 991791010155 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 991791010156 nucleotide binding region [chemical binding]; other site 991791010157 ATP-binding site [chemical binding]; other site 991791010158 This domain is found in proteins necessary for strand-specific repair in DNA such as TRCF in Escherichia coli; Region: TRCF; smart00982 991791010159 Peptidyl-tRNA hydrolase (PTH) is a monomeric protein that cleaves the ester bond linking the nascent peptide and tRNA when peptidyl-tRNA is released prematurely from the ribosome. This ensures the recycling of peptidyl-tRNAs into tRNAs produced through...; Region: PTH; cd00462 991791010160 putative active site [active] 991791010161 catalytic residue [active] 991791010162 Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain [Posttranslational modification, protein turnover, chaperones]; Region: DegQ; COG0265 991791010163 Trypsin-like peptidase domain; Region: Trypsin_2; pfam13365 991791010164 PDZ domain of tryspin-like serine proteases, such as DegP/HtrA, which are oligomeric proteins involved in heat-shock response, chaperone function, and apoptosis. May be responsible for substrate recognition and/or binding, as most PDZ domains bind...; Region: PDZ_serine_protease; cd00987 991791010165 protein binding site [polypeptide binding]; other site 991791010166 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 991791010167 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 991791010168 dimerization interface [polypeptide binding]; other site 991791010169 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 991791010170 dimer interface [polypeptide binding]; other site 991791010171 phosphorylation site [posttranslational modification] 991791010172 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 991791010173 ATP binding site [chemical binding]; other site 991791010174 Mg2+ binding site [ion binding]; other site 991791010175 G-X-G motif; other site 991791010176 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 991791010177 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 991791010178 active site 991791010179 phosphorylation site [posttranslational modification] 991791010180 intermolecular recognition site; other site 991791010181 dimerization interface [polypeptide binding]; other site 991791010182 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 991791010183 DNA binding site [nucleotide binding] 991791010184 ribose-phosphate pyrophosphokinase; Provisional; Region: PRK01259 991791010185 N-terminal domain of ribose phosphate pyrophosphokinase; Region: Pribosyltran_N; pfam13793 991791010186 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 991791010187 active site 991791010188 bifunctional N-acetylglucosamine-1-phosphate uridyltransferase/glucosamine-1-phosphate acetyltransferase; Provisional; Region: glmU; PRK14354 991791010189 N-terminal domain of bacterial GlmU; Region: GT2_GlmU_N_bac; cd02540 991791010190 Substrate binding site; other site 991791010191 Mg++ binding site; other site 991791010192 N-acetyl-glucosamine-1-phosphate uridyltransferase (GlmU), C-terminal left-handed beta-helix (LbH) acetyltransferase domain: GlmU is also known as UDP-N-acetylglucosamine pyrophosphorylase. It is a bifunctional bacterial enzyme that catalyzes two...; Region: LbH_GlmU_C; cd03353 991791010193 active site 991791010194 substrate binding site [chemical binding]; other site 991791010195 CoA binding site [chemical binding]; other site 991791010196 regulatory protein SpoVG; Reviewed; Region: PRK13259 991791010197 pur operon repressor; Provisional; Region: PRK09213 991791010198 Bacterial purine repressor, N-terminal; Region: PuR_N; pfam09182 991791010199 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 991791010200 active site 991791010201 UDP-N-acetylmuramate--L-alanine ligase; Provisional; Region: murC; PRK00421 991791010202 Mur ligase family, catalytic domain; Region: Mur_ligase; pfam01225 991791010203 Mur ligase middle domain; Region: Mur_ligase_M; pfam08245 991791010204 Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875 991791010205 NADH:flavin oxidoreductases, Old Yellow Enzyme family [Energy production and conversion]; Region: NemA; COG1902 991791010206 Old yellow enzyme (OYE) YqjM-like FMN binding domain. YqjM is involved in the oxidative stress response of Bacillus subtilis. Like the other OYE members, each monomer of YqjM contains FMN as a non-covalently bound cofactor and uses NADPH as a reducing...; Region: OYE_YqiM_FMN; cd02932 991791010207 active site 991791010208 FMN binding site [chemical binding]; other site 991791010209 substrate binding site [chemical binding]; other site 991791010210 homotetramer interface [polypeptide binding]; other site 991791010211 catalytic residue [active] 991791010212 Iron only hydrogenase large subunit, C-terminal domain [General function prediction only]; Region: COG4624 991791010213 Iron only hydrogenase large subunit, C-terminal domain; Region: Fe_hyd_lg_C; pfam02906 991791010214 Predicted phosphatase/phosphohexomutase [General function prediction only]; Region: COG0637 991791010215 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 991791010216 active site 991791010217 motif I; other site 991791010218 motif II; other site 991791010219 2-phosphosulfolactate phosphatase; Provisional; Region: PRK00886 991791010220 Phosphosulfolactate phosphohydrolase and related enzymes [Coenzyme metabolism / General function prediction only]; Region: COG2045 991791010221 Predicted membrane protein [Function unknown]; Region: COG4640 991791010222 zinc-ribbon domain; Region: zinc_ribbon_2; pfam13240 991791010223 Predicted membrane protein [Function unknown]; Region: COG4640 991791010224 Regulator of polyketide synthase expression [Signal transduction mechanisms / Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG2508 991791010225 PucR C-terminal helix-turn-helix domain; Region: HTH_30; pfam13556 991791010226 glycerol-3-phosphate transporter ATP-binding subunit; Provisional; Region: ugpC; PRK11650 991791010227 The N-terminal ATPase domain of the maltose transporter, MalK; Region: ABC_MalK_N; cd03301 991791010228 Walker A/P-loop; other site 991791010229 ATP binding site [chemical binding]; other site 991791010230 Q-loop/lid; other site 991791010231 ABC transporter signature motif; other site 991791010232 Walker B; other site 991791010233 D-loop; other site 991791010234 H-loop/switch region; other site 991791010235 TOBE domain; Region: TOBE_2; pfam08402 991791010236 Predicted Fe-S oxidoreductase [General function prediction only]; Region: COG1242 991791010237 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 991791010238 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 991791010239 putative DNA binding site [nucleotide binding]; other site 991791010240 putative Zn2+ binding site [ion binding]; other site 991791010241 Uncharacterized membrane protein [Function unknown]; Region: COG3949 991791010242 Radical SAM superfamily; Region: Radical_SAM; pfam04055 991791010243 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 991791010244 FeS/SAM binding site; other site 991791010245 Heme NO binding; Region: HNOB; pfam07700 991791010246 Cobalamin-5-phosphate synthase; Region: CobS; cl00415 991791010247 Methyl-accepting chemotaxis protein [Cell motility and secretion / Signal transduction mechanisms]; Region: Tar; COG0840 991791010248 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 991791010249 dimer interface [polypeptide binding]; other site 991791010250 putative CheW interface [polypeptide binding]; other site 991791010251 Putative peptidoglycan-binding domain-containing protein [Cell envelope biogenesis, outer membrane]; Region: COG3409 991791010252 Putative peptidoglycan binding domain; Region: PG_binding_1; pfam01471 991791010253 Subtilisin-like serine proteases [Posttranslational modification, protein turnover, chaperones]; Region: AprE; COG1404 991791010254 Peptidase S8 family domain in CspA-like proteins; Region: Peptidases_S8_CspA-like; cd07478 991791010255 active site 991791010256 catalytic triad [active] 991791010257 Subtilisin-like serine proteases [Posttranslational modification, protein turnover, chaperones]; Region: AprE; COG1404 991791010258 Peptidase S8 family domain in CspA-like proteins; Region: Peptidases_S8_CspA-like; cd07478 991791010259 active site 991791010260 catalytic triad [active] 991791010261 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 991791010262 non-specific DNA binding site [nucleotide binding]; other site 991791010263 salt bridge; other site 991791010264 sequence-specific DNA binding site [nucleotide binding]; other site 991791010265 Peptidase S24 LexA-like proteins are involved in the SOS response leading to the repair of single-stranded DNA within the bacterial cell. This family includes: the lambda repressor CI/C2 family and related bacterial prophage repressor proteins; LexA (EC...; Region: S24_LexA-like; cd06529 991791010266 Catalytic site [active] 991791010267 Domain of unknown function (DUF3783); Region: DUF3783; pfam12646 991791010268 glutamate racemase; Provisional; Region: PRK00865 991791010269 Response regulator containing a CheY-like receiver domain and an HD-GYP domain [Transcription / Signal transduction mechanisms]; Region: COG3437 991791010270 Domain of unknown function (DUF3369); Region: DUF3369; pfam11849 991791010271 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 991791010272 Zn2+ binding site [ion binding]; other site 991791010273 Mg2+ binding site [ion binding]; other site 991791010274 pyrroline-5-carboxylate reductase; Reviewed; Region: PRK11880 991791010275 pyrroline-5-carboxylate reductase; Region: PLN02688 991791010276 gamma-glutamyl kinase; Provisional; Region: PRK05429 991791010277 AAK_G5K_ProB: Glutamate-5-kinase (G5K) catalyzes glutamate-dependent ATP cleavage; G5K transfers the terminal phosphoryl group of ATP to the gamma-carboxyl group of glutamate, in the first and controlling step of proline (and, in mammals, ornithine)...; Region: AAK_G5K_ProB; cd04242 991791010278 nucleotide binding site [chemical binding]; other site 991791010279 homotetrameric interface [polypeptide binding]; other site 991791010280 putative phosphate binding site [ion binding]; other site 991791010281 putative allosteric binding site; other site 991791010282 Gamma-glutamyl phosphate reductase (GPR), aldehyde dehydrogenase families 18 and 19; Region: ALDH_F18-19_ProA-GPR; cd07079 991791010283 gamma-glutamyl phosphate reductase; Region: proA; TIGR00407 991791010284 putative catalytic cysteine [active] 991791010285 Acetyltransferases [General function prediction only]; Region: RimI; COG0456 991791010286 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 991791010287 Coenzyme A binding pocket [chemical binding]; other site 991791010288 asparaginyl-tRNA synthetase; Validated; Region: asnC; PRK03932 991791010289 EcAsnRS_like_N: N-terminal, anticodon recognition domain of the type found in Escherichia coli asparaginyl-tRNA synthetase (AsnRS) and, in Arabidopsis thaliana and Saccharomyces cerevisiae mitochondrial (mt) AsnRS. This domain is a beta-barrel domain (OB...; Region: EcAsnRS_like_N; cd04318 991791010290 putative dimer interface [polypeptide binding]; other site 991791010291 putative anticodon binding site; other site 991791010292 Asx tRNA synthetase (AspRS/AsnRS) class II core domain. Assignment to class II aminoacyl-tRNA synthetases (aaRS) based upon its structure and the presence of three characteristic sequence motifs in the core domain. This family includes AsnRS as well as...; Region: AsxRS_core; cd00776 991791010293 homodimer interface [polypeptide binding]; other site 991791010294 motif 1; other site 991791010295 motif 2; other site 991791010296 active site 991791010297 motif 3; other site 991791010298 Methylated DNA-protein cysteine methyltransferase [DNA replication, recombination, and repair]; Region: Ada; COG0350 991791010299 The DNA repair protein O6-alkylguanine-DNA alkyltransferase (ATase; also known as AGT, AGAT and MGMT) reverses O6-alkylation DNA damage by transferring O6-alkyl adducts to an active site cysteine irreversibly, without inducing DNA strand breaks. ATases...; Region: ATase; cd06445 991791010300 DNA binding site [nucleotide binding] 991791010301 active site 991791010302 Predicted ATPase (AAA+ superfamily) [General function prediction only]; Region: COG2607 991791010303 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 991791010304 Walker A motif; other site 991791010305 ATP binding site [chemical binding]; other site 991791010306 Walker B motif; other site 991791010307 Uncharacterized conserved protein [Function unknown]; Region: COG3874 991791010308 Protein of unknown function (DUF2953); Region: DUF2953; pfam11167 991791010309 Putative zinc-finger; Region: zf-HC2; pfam13490 991791010310 DNA-directed RNA polymerase specialized sigma subunit, sigma24 homolog [Transcription]; Region: RpoE; COG1595 991791010311 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 991791010312 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 991791010313 DNA binding residues [nucleotide binding] 991791010314 ABC-2 family transporter protein; Region: ABC2_membrane_3; pfam12698 991791010315 ABC-type multidrug transport system, permease component [Defense mechanisms]; Region: COG0842 991791010316 ABC-2 type transporter; Region: ABC2_membrane; pfam01061 991791010317 ABC-type Na+ transport system, ATPase component [Energy production and conversion / Inorganic ion transport and metabolism]; Region: NatA; COG4555 991791010318 ATP-binding cassette domain of the drug resistance transporter and related proteins, subfamily A; Region: ABC_DR_subfamily_A; cd03230 991791010319 Walker A/P-loop; other site 991791010320 ATP binding site [chemical binding]; other site 991791010321 Q-loop/lid; other site 991791010322 ABC transporter signature motif; other site 991791010323 Walker B; other site 991791010324 D-loop; other site 991791010325 H-loop/switch region; other site 991791010326 Membrane-fusion protein [Cell envelope biogenesis, outer membrane]; Region: AcrA; COG0845 991791010327 Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533 991791010328 HlyD family secretion protein; Region: HlyD_3; pfam13437 991791010329 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 991791010330 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 991791010331 Bacterial surface proteins containing Ig-like domains [Cell motility and secretion]; Region: COG5492 991791010332 Clostridial hydrophobic, with a conserved W residue, domain; Region: ChW; smart00728 991791010333 Clostridial hydrophobic, with a conserved W residue, domain; Region: ChW; smart00728 991791010334 Clostridial hydrophobic, with a conserved W residue, domain; Region: ChW; smart00728 991791010335 Bacterial surface proteins containing Ig-like domains [Cell motility and secretion]; Region: COG5492 991791010336 Clostridial hydrophobic, with a conserved W residue, domain; Region: ChW; smart00728 991791010337 Clostridial hydrophobic, with a conserved W residue, domain; Region: ChW; smart00728 991791010338 Clostridial hydrophobic, with a conserved W residue, domain; Region: ChW; smart00728 991791010339 Bacterial Ig-like domain (group 2); Region: Big_2; pfam02368 991791010340 Leucine Rich repeats (2 copies); Region: LRR_4; pfam12799 991791010341 Leucine Rich repeats (2 copies); Region: LRR_4; pfam12799 991791010342 Bacterial surface proteins containing Ig-like domains [Cell motility and secretion]; Region: COG5492 991791010343 Clostridial hydrophobic, with a conserved W residue, domain; Region: ChW; smart00728 991791010344 Clostridial hydrophobic, with a conserved W residue, domain; Region: ChW; smart00728 991791010345 Clostridial hydrophobic, with a conserved W residue, domain; Region: ChW; smart00728 991791010346 Leucine Rich repeats (2 copies); Region: LRR_4; pfam12799 991791010347 Leucine Rich repeats (2 copies); Region: LRR_4; pfam12799 991791010348 Bacterial surface proteins containing Ig-like domains [Cell motility and secretion]; Region: COG5492 991791010349 Clostridial hydrophobic, with a conserved W residue, domain; Region: ChW; smart00728 991791010350 Clostridial hydrophobic, with a conserved W residue, domain; Region: ChW; smart00728 991791010351 Clostridial hydrophobic, with a conserved W residue, domain; Region: ChW; smart00728 991791010352 Bacterial surface proteins containing Ig-like domains [Cell motility and secretion]; Region: COG5492 991791010353 Clostridial hydrophobic, with a conserved W residue, domain; Region: ChW; smart00728 991791010354 Clostridial hydrophobic, with a conserved W residue, domain; Region: ChW; smart00728 991791010355 Clostridial hydrophobic, with a conserved W residue, domain; Region: ChW; smart00728 991791010356 Leucine-rich repeat (LRR) protein [Function unknown]; Region: COG4886 991791010357 Bacterial surface proteins containing Ig-like domains [Cell motility and secretion]; Region: COG5492 991791010358 Clostridial hydrophobic, with a conserved W residue, domain; Region: ChW; smart00728 991791010359 Clostridial hydrophobic, with a conserved W residue, domain; Region: ChW; smart00728 991791010360 Clostridial hydrophobic, with a conserved W residue, domain; Region: ChW; smart00728 991791010361 Bacterial surface proteins containing Ig-like domains [Cell motility and secretion]; Region: COG5492 991791010362 Clostridial hydrophobic, with a conserved W residue, domain; Region: ChW; smart00728 991791010363 Clostridial hydrophobic, with a conserved W residue, domain; Region: ChW; smart00728 991791010364 Clostridial hydrophobic, with a conserved W residue, domain; Region: ChW; smart00728 991791010365 Bacterial Ig-like domain (group 2); Region: Big_2; cl02708 991791010366 Clostridial hydrophobic, with a conserved W residue, domain; Region: ChW; smart00728 991791010367 Bacterial surface proteins containing Ig-like domains [Cell motility and secretion]; Region: COG5492 991791010368 Clostridial hydrophobic, with a conserved W residue, domain; Region: ChW; smart00728 991791010369 Bacterial Ig-like domain (group 2); Region: Big_2; pfam02368 991791010370 Bacterial Ig-like domain (group 2); Region: Big_2; cl02708 991791010371 Leucine Rich repeats (2 copies); Region: LRR_4; pfam12799 991791010372 Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 residue sequence motifs present in many proteins that participate in protein-protein interactions and have different functions and cellular locations. LRRs correspond...; Region: LRR_RI; cl15309 991791010373 Leucine Rich repeats (2 copies); Region: LRR_4; pfam12799 991791010374 Ribonucleotide Reductase, R2/beta subunit, ferritin-like diiron-binding domain; Region: RNRR2; cd01049 991791010375 dimer interface [polypeptide binding]; other site 991791010376 putative radical transfer pathway; other site 991791010377 diiron center [ion binding]; other site 991791010378 tyrosyl radical; other site 991791010379 ribonucleotide-diphosphate reductase subunit alpha; Validated; Region: PRK07088 991791010380 Class I ribonucleotide reductase; Region: RNR_I; cd01679 991791010381 active site 991791010382 dimer interface [polypeptide binding]; other site 991791010383 catalytic residues [active] 991791010384 effector binding site; other site 991791010385 R2 peptide binding site; other site 991791010386 Bacterial surface proteins containing Ig-like domains [Cell motility and secretion]; Region: COG5492 991791010387 Clostridial hydrophobic, with a conserved W residue, domain; Region: ChW; smart00728 991791010388 Clostridial hydrophobic, with a conserved W residue, domain; Region: ChW; smart00728 991791010389 Clostridial hydrophobic, with a conserved W residue, domain; Region: ChW; smart00728 991791010390 Bacterial Ig-like domain (group 2); Region: Big_2; pfam02368 991791010391 Bacterial surface proteins containing Ig-like domains [Cell motility and secretion]; Region: COG5492 991791010392 Clostridial hydrophobic, with a conserved W residue, domain; Region: ChW; smart00728 991791010393 Clostridial hydrophobic, with a conserved W residue, domain; Region: ChW; smart00728 991791010394 Clostridial hydrophobic, with a conserved W residue, domain; Region: ChW; smart00728 991791010395 Bacterial Ig-like domain (group 2); Region: Big_2; pfam02368 991791010396 Bacterial surface proteins containing Ig-like domains [Cell motility and secretion]; Region: COG5492 991791010397 Clostridial hydrophobic, with a conserved W residue, domain; Region: ChW; smart00728 991791010398 Clostridial hydrophobic, with a conserved W residue, domain; Region: ChW; smart00728 991791010399 Clostridial hydrophobic, with a conserved W residue, domain; Region: ChW; smart00728 991791010400 Bacterial Ig-like domain (group 2); Region: Big_2; pfam02368 991791010401 Leucine Rich repeats (2 copies); Region: LRR_4; pfam12799 991791010402 Bacterial surface proteins containing Ig-like domains [Cell motility and secretion]; Region: COG5492 991791010403 Clostridial hydrophobic, with a conserved W residue, domain; Region: ChW; smart00728 991791010404 Clostridial hydrophobic, with a conserved W residue, domain; Region: ChW; smart00728 991791010405 Clostridial hydrophobic, with a conserved W residue, domain; Region: ChW; smart00728 991791010406 Bacterial Ig-like domain (group 2); Region: Big_2; pfam02368 991791010407 Bacterial surface proteins containing Ig-like domains [Cell motility and secretion]; Region: COG5492 991791010408 Clostridial hydrophobic, with a conserved W residue, domain; Region: ChW; smart00728 991791010409 Clostridial hydrophobic, with a conserved W residue, domain; Region: ChW; smart00728 991791010410 Clostridial hydrophobic, with a conserved W residue, domain; Region: ChW; smart00728 991791010411 Bacterial Ig-like domain (group 2); Region: Big_2; pfam02368 991791010412 Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 residue sequence motifs present in many proteins that participate in protein-protein interactions and have different functions and cellular locations. LRRs correspond...; Region: LRR_RI; cl15309 991791010413 Leucine rich repeat; Region: LRR_8; pfam13855 991791010414 Substrate binding site [chemical binding]; other site 991791010415 Leucine Rich repeats (2 copies); Region: LRR_4; pfam12799 991791010416 Leucine Rich repeats (2 copies); Region: LRR_4; pfam12799 991791010417 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 991791010418 ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132 991791010419 ATP-binding cassette domain of glucan transporter and related proteins, subfamily C; Region: ABCC_Glucan_exporter_like; cd03254 991791010420 Walker A/P-loop; other site 991791010421 ATP binding site [chemical binding]; other site 991791010422 Q-loop/lid; other site 991791010423 ABC transporter signature motif; other site 991791010424 Walker B; other site 991791010425 D-loop; other site 991791010426 H-loop/switch region; other site 991791010427 ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132 991791010428 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 991791010429 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 991791010430 Walker A/P-loop; other site 991791010431 ATP binding site [chemical binding]; other site 991791010432 Q-loop/lid; other site 991791010433 ABC transporter signature motif; other site 991791010434 Walker B; other site 991791010435 D-loop; other site 991791010436 H-loop/switch region; other site 991791010437 helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347 991791010438 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 991791010439 dimerization interface [polypeptide binding]; other site 991791010440 putative Zn2+ binding site [ion binding]; other site 991791010441 putative DNA binding site [nucleotide binding]; other site 991791010442 EDD domain protein, DegV family; Region: DegV; TIGR00762 991791010443 Uncharacterized protein, DegV family COG1307; Region: DegV; pfam02645 991791010444 amino acid transporter; Region: 2A0306; TIGR00909 991791010445 C-terminus of AA_permease; Region: AA_permease_C; pfam13906 991791010446 Response regulator receiver domain; Region: Response_reg; pfam00072 991791010447 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 991791010448 intermolecular recognition site; other site 991791010449 active site 991791010450 dimerization interface [polypeptide binding]; other site 991791010451 YcbB domain; Region: YcbB; pfam08664 991791010452 FeS assembly ATPase SufC; Region: sufC; TIGR01978 991791010453 ABC-type transport system involved in Fe-S cluster assembly, ATPase component; Region: ABC_FeS_Assembly; cd03217 991791010454 Walker A/P-loop; other site 991791010455 ATP binding site [chemical binding]; other site 991791010456 Q-loop/lid; other site 991791010457 ABC transporter signature motif; other site 991791010458 Walker B; other site 991791010459 D-loop; other site 991791010460 H-loop/switch region; other site 991791010461 FeS assembly protein SufB; Region: sufB; TIGR01980 991791010462 cysteine desulfurase activator complex subunit SufB; Provisional; Region: PRK11814; cl03223 991791010463 FeS assembly protein SufD; Region: sufD; TIGR01981 991791010464 Uncharacterized protein family (UPF0051); Region: UPF0051; pfam01458 991791010465 Selenocysteine lyase/Cysteine desulfurase [Posttranslational modification, protein turnover, chaperones]; Region: csdA; COG0520 991791010466 Cysteine desulfurase (SufS)-like. This family belongs to the pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to cysteine desulfurase (SufS) and selenocysteine lyase. SufS...; Region: SufS_like; cd06453 991791010467 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 991791010468 catalytic residue [active] 991791010469 NifU homolog involved in Fe-S cluster formation [Energy production and conversion]; Region: IscU; COG0822 991791010470 Iron-sulfur cluster scaffold-like proteins; Region: IscU_like; cd06664 991791010471 trimerization site [polypeptide binding]; other site 991791010472 active site 991791010473 O-Antigen ligase; Region: Wzy_C; pfam04932 991791010474 Lipid A core - O-antigen ligase and related enzymes [Cell envelope biogenesis, outer membrane]; Region: RfaL; COG3307 991791010475 Subfamily of the multidrug and toxic compound extrusion (MATE)-like proteins similar to Streptococcus aureus MepA; Region: MATE_MepA_like; cd13143 991791010476 Na+-driven multidrug efflux pump [Defense mechanisms]; Region: NorM; COG0534 991791010477 AraC-like ligand binding domain; Region: AraC_binding; pfam02311 991791010478 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 991791010479 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 991791010480 Beta-xylosidase [Carbohydrate transport and metabolism]; Region: XynB; COG3664 991791010481 D-alanyl-D-alanine carboxypeptidase [Cell envelope biogenesis, outer membrane]; Region: VanY; COG1876 991791010482 D-alanyl-D-alanine carboxypeptidase; Region: VanY; pfam02557 991791010483 Uncharacterized oxidoreductases, Fe-dependent alcohol dehydrogenase family [Energy production and conversion]; Region: COG1979 991791010484 Butanol dehydrogenase catalyzes the conversion of butyraldehyde to butanol with the cofactor NAD(P)H being oxidized in the process; Region: BDH; cd08187 991791010485 dimer interface [polypeptide binding]; other site 991791010486 active site 991791010487 metal binding site [ion binding]; metal-binding site 991791010488 Uncharacterized oxidoreductases, Fe-dependent alcohol dehydrogenase family [Energy production and conversion]; Region: COG1979 991791010489 Butanol dehydrogenase catalyzes the conversion of butyraldehyde to butanol with the cofactor NAD(P)H being oxidized in the process; Region: BDH; cd08187 991791010490 dimer interface [polypeptide binding]; other site 991791010491 active site 991791010492 metal binding site [ion binding]; metal-binding site 991791010493 Bacillus/Clostridium GerA spore germination protein; Region: GerA; pfam03323 991791010494 Spore germination protein; Region: Spore_permease; pfam03845 991791010495 germination protein, Ger(x)C family; Region: spore_ger_x_C; TIGR02887 991791010496 Spore germination B3/ GerAC like, C-terminal; Region: Spore_GerAC; pfam05504 991791010497 Bacterial SNF2 helicase associated; Region: SNF2_assoc; pfam08455 991791010498 SNF2 family N-terminal domain; Region: SNF2_N; pfam00176 991791010499 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 991791010500 ATP binding site [chemical binding]; other site 991791010501 putative Mg++ binding site [ion binding]; other site 991791010502 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 991791010503 nucleotide binding region [chemical binding]; other site 991791010504 ATP-binding site [chemical binding]; other site 991791010505 Peroxiredoxin (PRX) family, Atypical 2-cys PRX subfamily; composed of PRXs containing peroxidatic and resolving cysteines, similar to the homodimeric thiol specific antioxidant (TSA) protein also known as TRX-dependent thiol peroxidase (Tpx). Tpx is a...; Region: PRX_Atyp2cys; cd03014 991791010506 dimer interface [polypeptide binding]; other site 991791010507 catalytic triad [active] 991791010508 peroxidatic and resolving cysteines [active] 991791010509 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cl02429 991791010510 binding surface 991791010511 TPR motif; other site 991791010512 UDP-glucose LOS-beta-1,4 glucosyltransferase is required for biosynthesis of lipooligosaccharide; Region: Beta4Glucosyltransferase; cd02511 991791010513 putative metal binding site; other site 991791010514 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cl02429 991791010515 TPR motif; other site 991791010516 binding surface 991791010517 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 991791010518 TPR motif; other site 991791010519 binding surface 991791010520 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 991791010521 binding surface 991791010522 TPR motif; other site 991791010523 hypothetical protein; Provisional; Region: PRK09946 991791010524 UDP-N-acetyl-D-mannosaminuronate dehydrogenase [Cell envelope biogenesis, outer membrane]; Region: WecC; COG0677 991791010525 UDP-glucose/GDP-mannose dehydrogenase family, central domain; Region: UDPG_MGDP_dh; pfam00984 991791010526 UDP-glucose/GDP-mannose dehydrogenase family, UDP binding domain; Region: UDPG_MGDP_dh_C; pfam03720 991791010527 Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013 991791010528 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 991791010529 Predicted enzyme involved in methoxymalonyl-ACP biosynthesis [Secondary metabolites biosynthesis, transport, and catabolism]; Region: FkbH; COG3882 991791010530 Acid Phosphatase; Region: Acid_PPase; cl17256 991791010531 Acyl carrier protein [Lipid metabolism / Secondary metabolites biosynthesis, transport, and catabolism]; Region: AcpP; COG0236 991791010532 Nitroreductase-like family 4. A subfamily of the nitroreductase family containing uncharacterized proteins that are similar to nitroreductase. Nitroreductase catalyzes the reduction of nitroaromatic compounds such as nitrotoluenes, nitrofurans and...; Region: Nitroreductase_4; cd02140 991791010533 dimer interface [polypeptide binding]; other site 991791010534 FMN binding site [chemical binding]; other site 991791010535 heat shock protein 90; Provisional; Region: PRK05218 991791010536 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 991791010537 ATP binding site [chemical binding]; other site 991791010538 Mg2+ binding site [ion binding]; other site 991791010539 G-X-G motif; other site 991791010540 cardiolipin synthetase; Reviewed; Region: cls; PRK01642 991791010541 Putative catalytic domain, repeat 1, of Streptococcus mutans uncharacterized protein SMU_988 and similar proteins; Region: PLDc_SMU_988_like_1; cd09154 991791010542 putative active site [active] 991791010543 catalytic site [active] 991791010544 Putative catalytic domain, repeat 2, of Streptococcus mutans uncharacterized protein SMU_988 and similar proteins; Region: PLDc_SMU_988_like_2; cd09160 991791010545 putative active site [active] 991791010546 catalytic site [active] 991791010547 Spore coat protein [Cell envelope biogenesis, outer membrane]; Region: COG5577 991791010548 Transcriptional activator of acetoin/glycerol metabolism [Secondary metabolites biosynthesis, transport, and catabolism / Transcription]; Region: AcoR; COG3284 991791010549 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 991791010550 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 991791010551 dimer interface [polypeptide binding]; other site 991791010552 phosphorylation site [posttranslational modification] 991791010553 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 991791010554 ATP binding site [chemical binding]; other site 991791010555 Mg2+ binding site [ion binding]; other site 991791010556 G-X-G motif; other site 991791010557 Putative amidase domain; Region: Amidase_6; pfam12671 991791010558 hypothetical protein; Provisional; Region: PRK00872 991791010559 Acetyltransferase (GNAT) domain; Region: Acetyltransf_3; pfam13302 991791010560 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 991791010561 non-specific DNA binding site [nucleotide binding]; other site 991791010562 salt bridge; other site 991791010563 sequence-specific DNA binding site [nucleotide binding]; other site 991791010564 Bacterial extracellular solute-binding proteins, family 3; Region: SBP_bac_3; pfam00497 991791010565 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 991791010566 substrate binding pocket [chemical binding]; other site 991791010567 membrane-bound complex binding site; other site 991791010568 hinge residues; other site 991791010569 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 991791010570 dimer interface [polypeptide binding]; other site 991791010571 conserved gate region; other site 991791010572 putative PBP binding loops; other site 991791010573 ABC-ATPase subunit interface; other site 991791010574 ABC-type polar amino acid transport system, ATPase component [Amino acid transport and metabolism]; Region: GlnQ; COG1126 991791010575 ATP-binding cassette domain of the histidine and glutamine transporters; Region: ABC_HisP_GlnQ; cd03262 991791010576 Walker A/P-loop; other site 991791010577 ATP binding site [chemical binding]; other site 991791010578 Q-loop/lid; other site 991791010579 ABC transporter signature motif; other site 991791010580 Walker B; other site 991791010581 D-loop; other site 991791010582 H-loop/switch region; other site 991791010583 Mn2+ and Fe2+ transporters of the NRAMP family [Inorganic ion transport and metabolism]; Region: MntH; COG1914 991791010584 Natural resistance-associated macrophage protein; Region: Nramp; pfam01566 991791010585 Cytochrome P450 [Secondary metabolites biosynthesis, transport, and catabolism]; Region: CypX; COG2124 991791010586 Cytochrome P450; Region: p450; cl12078 991791010587 Cytochrome P450; Region: p450; cl12078 991791010588 Alanine racemase [Cell envelope biogenesis, outer membrane]; Region: Alr; COG0787 991791010589 Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzyme Alanine Racemase; Region: PLPDE_III_AR; cd00430 991791010590 active site 991791010591 pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site 991791010592 dimer interface [polypeptide binding]; other site 991791010593 substrate binding site [chemical binding]; other site 991791010594 catalytic residues [active] 991791010595 Imidazolonepropionase and related amidohydrolases [Secondary metabolites biosynthesis, transport, and catabolism]; Region: HutI; COG1228 991791010596 Metallo-dependent hydrolases, subgroup C is part of the superfamily of metallo-dependent hydrolases, a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the...; Region: Met_dep_hydrolase_C; cd01309 991791010597 active site 991791010598 Uncharacterized conserved protein related to pyruvate formate-lyase activating enzyme [General function prediction only]; Region: COG2108 991791010599 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 991791010600 FeS/SAM binding site; other site 991791010601 Multimeric flavodoxin WrbA [General function prediction only]; Region: WrbA; COG0655 991791010602 NADPH-dependent FMN reductase; Region: FMN_red; pfam03358 991791010603 17beta hydroxysteroid dehydrogenase-like, classical (c) SDRs; Region: 17beta-HSD-like_SDR_c; cd05374 991791010604 short chain dehydrogenase; Provisional; Region: PRK09291 991791010605 NADP binding site [chemical binding]; other site 991791010606 active site 991791010607 steroid binding site; other site 991791010608 cAMP-binding proteins - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases [Signal transduction mechanisms]; Region: Crp; COG0664 991791010609 effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038 991791010610 ligand binding site [chemical binding]; other site 991791010611 flexible hinge region; other site 991791010612 Predicted metal-dependent hydrolase of the TIM-barrel fold [General function prediction only]; Region: COG2159 991791010613 Predicted transcriptional regulators [Transcription]; Region: COG1733 991791010614 HxlR-like helix-turn-helix; Region: HxlR; pfam01638 991791010615 ATPase components of ABC transporters with duplicated ATPase domains [General function prediction only]; Region: Uup; COG0488 991791010616 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 991791010617 Walker A/P-loop; other site 991791010618 ATP binding site [chemical binding]; other site 991791010619 Q-loop/lid; other site 991791010620 ABC transporter signature motif; other site 991791010621 Walker B; other site 991791010622 D-loop; other site 991791010623 H-loop/switch region; other site 991791010624 ABC transporter; Region: ABC_tran_2; pfam12848 991791010625 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 991791010626 Nucleotidyltransferase (NT) domain of RelA- and SpoT-like ppGpp synthetases and hydrolases; Region: NT_Rel-Spo_like; cd05399 991791010627 synthetase active site [active] 991791010628 NTP binding site [chemical binding]; other site 991791010629 metal binding site [ion binding]; metal-binding site 991791010630 Multimeric flavodoxin WrbA [General function prediction only]; Region: WrbA; COG0655 991791010631 NADPH-dependent FMN reductase; Region: FMN_red; pfam03358 991791010632 3-hydroxyisobutyrate dehydrogenase and related beta-hydroxyacid dehydrogenases [Lipid metabolism]; Region: MmsB; COG2084 991791010633 6-phosphogluconate dehydrogenase-like protein; Reviewed; Region: PRK09599 991791010634 putative DNA modification/repair radical SAM protein; Region: rSAM_link_UDG; TIGR03916 991791010635 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 991791010636 FeS/SAM binding site; other site 991791010637 probable DNA metabolism protein; Region: SAM_7_link_chp; TIGR03915 991791010638 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 991791010639 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 991791010640 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 991791010641 putative transporter; Provisional; Region: PRK10504 991791010642 putative substrate translocation pore; other site 991791010643 lysine transporter; Provisional; Region: PRK10836 991791010644 homocysteine methyltransferase; Provisional; Region: mmuM; PRK09485 991791010645 Homocysteine S-methyltransferase; Region: S-methyl_trans; pfam02574 991791010646 Transcriptional regulator [Transcription]; Region: LysR; COG0583 991791010647 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 991791010648 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cd05466 991791010649 dimerization interface [polypeptide binding]; other site 991791010650 Putative intracellular protease/amidase [General function prediction only]; Region: ThiJ; COG0693 991791010651 Type 1 glutamine amidotransferase (GATase1)-like domain found in Human DJ-1; Region: GATase1_DJ-1; cd03135 991791010652 conserved cys residue [active] 991791010653 Protein of unknown function (DUF2512); Region: DUF2512; pfam10710 991791010654 Cache domain; Region: Cache_1; pfam02743 991791010655 Methyl-accepting chemotaxis protein [Cell motility and secretion / Signal transduction mechanisms]; Region: Tar; COG0840 991791010656 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cl01054 991791010657 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 991791010658 dimer interface [polypeptide binding]; other site 991791010659 putative CheW interface [polypeptide binding]; other site 991791010660 Subfamily of the multidrug and toxic compound extrusion (MATE)-like proteins similar to Bacillus subtilis yoeA; Region: MATE_yoeA_like; cd13138 991791010661 Na+-driven multidrug efflux pump [Defense mechanisms]; Region: NorM; COG0534 991791010662 Polyketide synthase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG3321 991791010663 polyketide synthases (PKSs) polymerize simple fatty acids into a large variety of different products, called polyketides, by successive decarboxylating Claisen condensations. PKSs can be divided into 2 groups, modular type I PKSs consisting of one or...; Region: PKS; cd00833 991791010664 active site 991791010665 Acyl transferase domain in polyketide synthase (PKS) enzymes; Region: PKS_AT; smart00827 991791010666 Dehydratase domain in polyketide synthase (PKS) enzymes; Region: PKS_DH; smart00826 991791010667 beta-ketoacyl reductase (KR) domain of fatty acid synthase (FAS), subgroup 2, complex (x); Region: KR_2_FAS_SDR_x; cd08955 991791010668 KR domain; Region: KR; pfam08659 991791010669 putative NADP binding site [chemical binding]; other site 991791010670 active site 991791010671 Phosphopantetheine attachment site; Region: PP-binding; pfam00550 991791010672 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 991791010673 This domain superfamily is found in a variety of structurally related metalloproteins, including the type I extradiol dioxygenases, glyoxalase I and a group of antibiotic resistance proteins; Region: Glo_EDI_BRP_like; cd06587 991791010674 active site 991791010675 Site-specific DNA methylase [DNA replication, recombination, and repair]; Region: Dam; COG0338 991791010676 4Fe-4S dicluster domain; Region: Fer4_10; pfam13237 991791010677 The HCP family of iron-sulfur proteins includes hybrid cluster protein (HCP), acetyl-CoA synthase (ACS), and carbon monoxide dehydrogenase (CODH), all of which contain [Fe4-S4] metal clusters at their active sites. These proteins have a conserved...; Region: HCP_like; cl14655 991791010678 4Fe-4S dicluster domain; Region: Fer4_10; pfam13237 991791010679 Proteins of this family catalyze the reduction of flavin or nitrocompounds using NAD(P)H as electron donor in a obligatory two-electron transfer, utilizing FMN or FAD as cofactor. They are often found to be homodimers. Enzymes of this family are...; Region: Nitro_FMN_reductase; cl00514 991791010680 FMN binding site [chemical binding]; other site 991791010681 dimer interface [polypeptide binding]; other site 991791010682 Transcriptional regulator [Transcription]; Region: LysR; COG0583 991791010683 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 991791010684 The substrate binding domain of LysR-type transcriptional regulator GltC, which activates gltA expression of glutamate synthase operon, contains type 2 periplasmic binding fold; Region: PBP2_GltC_like; cd08434 991791010685 putative dimerization interface [polypeptide binding]; other site 991791010686 Transcriptional regulator [Transcription]; Region: LysR; COG0583 991791010687 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 991791010688 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cd05466 991791010689 dimerization interface [polypeptide binding]; other site 991791010690 Predicted membrane protein [Function unknown]; Region: COG3619 991791010691 Barstar_SaI14_like contains sequences that are similar to SaI14, an RNAase inhibitor, which are members of the Barstar family. Barstar is an intracellular inhibitor of barnase, an extracellular ribonuclease of Bacillus amyloliquefaciens. Barstar binds...; Region: Barstar_SaI14_like; cd05143 991791010692 putative RNAase interaction site [polypeptide binding]; other site 991791010693 chaperonin GroEL; Reviewed; Region: groEL; PRK12849 991791010694 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 991791010695 putative substrate translocation pore; other site 991791010696 Major Facilitator Superfamily; Region: MFS_1; pfam07690 991791010697 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 991791010698 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 991791010699 Predicted transcriptional regulators [Transcription]; Region: COG1695 991791010700 Transcriptional regulator PadR-like family; Region: PadR; pfam03551 991791010701 Virulence activator alpha C-term; Region: Vir_act_alpha_C; pfam10400 991791010702 NADH:flavin oxidoreductases, Old Yellow Enzyme family [Energy production and conversion]; Region: NemA; COG1902 991791010703 Enoate reductase (ER)-like FMN-binding domain. Enoate reductase catalyzes the NADH-dependent reduction of carbon-carbon double bonds of several molecules, including nonactivated 2-enoates, alpha,beta-unsaturated aldehydes, cyclic ketones, and...; Region: ER_like_FMN; cd02931 991791010704 putative active site [active] 991791010705 putative FMN binding site [chemical binding]; other site 991791010706 putative substrate binding site [chemical binding]; other site 991791010707 putative catalytic residue [active] 991791010708 putative 4Fe-4S cluster binding site [ion binding]; other site 991791010709 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox_2; pfam07992 991791010710 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 991791010711 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 991791010712 Predicted membrane protein [Function unknown]; Region: COG2323 991791010713 Pectinesterase; Region: Pectinesterase; pfam01095 991791010714 putative pectinesterase; Region: PLN02432; cl01911 991791010715 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 991791010716 Acetyltransferases [General function prediction only]; Region: RimI; COG0456 991791010717 Coenzyme A binding pocket [chemical binding]; other site 991791010718 Glutathione-dependent formaldehyde dehydrogenase related proteins, child 1; Region: FDH_like_1; cd08283 991791010719 Threonine dehydrogenase and related Zn-dependent dehydrogenases [Amino acid transport and metabolism / General function prediction only]; Region: Tdh; COG1063 991791010720 NAD binding site [chemical binding]; other site 991791010721 catalytic Zn binding site [ion binding]; other site 991791010722 structural Zn binding site [ion binding]; other site 991791010723 Uncharacterized conserved protein, contains double-stranded beta-helix domain [Function unknown]; Region: COG1917 991791010724 Predicted xylanase/chitin deacetylase [Carbohydrate transport and metabolism]; Region: CDA1; COG0726 991791010725 Catalytic NodB homology domain of Streptococcus mutans polysaccharide deacetylase PgdA, Bacillus subtilis YheN, and similar proteins; Region: CE4_SmPgdA_like; cd10944 991791010726 NodB motif; other site 991791010727 active site 991791010728 catalytic site [active] 991791010729 Zn binding site [ion binding]; other site 991791010730 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 991791010731 Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248 991791010732 active site 991791010733 catalytic tetrad [active] 991791010734 Uncharacterized conserved protein [Function unknown]; Region: COG5663 991791010735 Metallo-beta-lactamase superfamily; Region: Lactamase_B; smart00849 991791010736 Membrane protease subunits, stomatin/prohibitin homologs [Posttranslational modification, protein turnover, chaperones]; Region: HflC; COG0330 991791010737 Band_7_stomatin_like: A subgroup of the band 7 domain of flotillin (reggie) like proteins similar to stomatin and podicin (two lipid raft-associated integral membrane proteins). Individual proteins of this band 7 domain family may cluster to form...; Region: Band_7_stomatin_like; cd03403 991791010738 hypothetical protein; Reviewed; Region: PRK09588 991791010739 Uncharacterized protein family UPF0027; Region: UPF0027; pfam01139 991791010740 hypothetical protein; Reviewed; Region: PRK09588 991791010741 release factor H-coupled RctB family protein; Region: release_rtcB; TIGR03073 991791010742 putative peptide chain release factor H; Region: release_prfH; TIGR03072 991791010743 Protein chain release factor B [Translation, ribosomal structure and biogenesis]; Region: PrfB; COG1186 991791010744 WYL domain; Region: WYL; pfam13280 991791010745 WYL domain; Region: WYL; pfam13280 991791010746 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 991791010747 dimer interface [polypeptide binding]; other site 991791010748 putative CheW interface [polypeptide binding]; other site 991791010749 Phage shock protein A (IM30), suppresses sigma54-dependent transcription [Transcription / Signal transduction mechanisms]; Region: PspA; COG1842 991791010750 Response regulator containing CheY-like receiver and SARP domains [Signal transduction mechanisms]; Region: COG3947 991791010751 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 991791010752 active site 991791010753 phosphorylation site [posttranslational modification] 991791010754 intermolecular recognition site; other site 991791010755 dimerization interface [polypeptide binding]; other site 991791010756 Transcriptional regulatory protein, C terminal; Region: Trans_reg_C; pfam00486 991791010757 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 991791010758 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 991791010759 dimer interface [polypeptide binding]; other site 991791010760 phosphorylation site [posttranslational modification] 991791010761 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 991791010762 ATP binding site [chemical binding]; other site 991791010763 Mg2+ binding site [ion binding]; other site 991791010764 G-X-G motif; other site 991791010765 Uncharacterized oxidoreductases, Fe-dependent alcohol dehydrogenase family [Energy production and conversion]; Region: COG1979 991791010766 Butanol dehydrogenase catalyzes the conversion of butyraldehyde to butanol with the cofactor NAD(P)H being oxidized in the process; Region: BDH; cd08187 991791010767 dimer interface [polypeptide binding]; other site 991791010768 active site 991791010769 metal binding site [ion binding]; metal-binding site 991791010770 Uncharacterized conserved protein [Function unknown]; Region: COG1359 991791010771 NTP pyrophosphohydrolases containing a Zn-finger, probably nucleic-acid-binding [DNA replication, recombination, and repair]; Region: NPY1; COG2816 991791010772 NADH pyrophosphatase-like rudimentary NUDIX domain; Region: NUDIX-like; pfam09296 991791010773 NADH pyrophosphatase zinc ribbon domain; Region: zf-NADH-PPase; pfam09297 991791010774 NADH pyrophosphatase, a member of the Nudix hydrolase superfamily, catalyzes the cleavage of NADH into reduced nicotinamide mononucleotide (NMNH) and AMP. Like other members of the Nudix family, it requires a divalent cation, such as Mg2+ or Mn2+, for...; Region: NADH_pyrophosphatase; cd03429 991791010775 putative NADH binding site [chemical binding]; other site 991791010776 putative active site [active] 991791010777 nudix motif; other site 991791010778 putative metal binding site [ion binding]; other site 991791010779 Four helix bundle sensory module for signal transduction; Region: 4HB_MCP_1; pfam12729 991791010780 Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer); Region: MA; smart00283 991791010781 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 991791010782 dimer interface [polypeptide binding]; other site 991791010783 putative CheW interface [polypeptide binding]; other site 991791010784 PhosphatidylEthanolamine-Binding Protein (PEBP) domain present in bacteria and archaea; Region: PEBP_bact_arch; cd00865 991791010785 substrate binding site [chemical binding]; other site 991791010786 Predicted transcriptional regulators [Transcription]; Region: COG1733 991791010787 HxlR-like helix-turn-helix; Region: HxlR; pfam01638 991791010788 Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673 991791010789 Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408 991791010790 Oxidoreductase family, C-terminal alpha/beta domain; Region: GFO_IDH_MocA_C; pfam02894 991791010791 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 991791010792 Prolyl oligopeptidase family; Region: Peptidase_S9; pfam00326 991791010793 ABC-type multidrug transport system, permease component [Defense mechanisms]; Region: COG0842 991791010794 ABC-2 type transporter; Region: ABC2_membrane; pfam01061 991791010795 ABC-2 family transporter protein; Region: ABC2_membrane_3; pfam12698 991791010796 ABC-type multidrug transport system, ATPase component [Defense mechanisms]; Region: CcmA; COG1131 991791010797 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 991791010798 Walker A/P-loop; other site 991791010799 ATP binding site [chemical binding]; other site 991791010800 Q-loop/lid; other site 991791010801 ABC transporter signature motif; other site 991791010802 Walker B; other site 991791010803 D-loop; other site 991791010804 H-loop/switch region; other site 991791010805 helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347 991791010806 MarR family; Region: MarR_2; pfam12802 991791010807 Acyl-CoA thioester hydrolase/BAAT N-terminal region; Region: Bile_Hydr_Trans; pfam04775 991791010808 Alpha/beta hydrolase family; Region: Abhydrolase_5; pfam12695 991791010809 BAAT / Acyl-CoA thioester hydrolase C terminal; Region: BAAT_C; pfam08840 991791010810 NADH:flavin oxidoreductases, Old Yellow Enzyme family [Energy production and conversion]; Region: NemA; COG1902 991791010811 Old yellow enzyme (OYE)-like FMN binding domain. OYE was the first flavin-dependent enzyme identified, however its true physiological role remains elusive to this day. Each monomer of OYE contains FMN as a non-covalently bound cofactor, uses NADPH as a...; Region: OYE_like_FMN_family; cd02803 991791010812 active site 991791010813 FMN binding site [chemical binding]; other site 991791010814 substrate binding site [chemical binding]; other site 991791010815 putative catalytic residue [active] 991791010816 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox_2; pfam07992 991791010817 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500 991791010818 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 991791010819 Transcriptional regulator [Transcription]; Region: LysR; COG0583 991791010820 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 991791010821 The C-terminal substrate binding domain of LysR-type transcriptional regulators involved in the catabolism of aromatic compounds and that of other related regulators, contains type 2 periplasmic binding fold; Region: PBP2_LTTR_aromatics_like; cd08414 991791010822 dimerization interface [polypeptide binding]; other site 991791010823 substrate binding pocket [chemical binding]; other site 991791010824 c-di-GMP phosphodiesterase class II (HD-GYP domain) [Signal transduction mechanisms]; Region: COG2206 991791010825 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 991791010826 Zn2+ binding site [ion binding]; other site 991791010827 Mg2+ binding site [ion binding]; other site 991791010828 GH3 auxin-responsive promoter; Region: GH3; pfam03321 991791010829 Putative protein-S-isoprenylcysteine methyltransferase [Posttranslational modification, protein turnover, chaperones]; Region: STE14; COG2020 991791010830 Transcriptional regulators [Transcription]; Region: MarR; COG1846 991791010831 MarR family; Region: MarR_2; pfam12802 991791010832 ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132 991791010833 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 991791010834 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 991791010835 Walker A/P-loop; other site 991791010836 ATP binding site [chemical binding]; other site 991791010837 Q-loop/lid; other site 991791010838 ABC transporter signature motif; other site 991791010839 Walker B; other site 991791010840 D-loop; other site 991791010841 H-loop/switch region; other site 991791010842 ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132 991791010843 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 991791010844 ATP-binding cassette domain of glucan transporter and related proteins, subfamily C; Region: ABCC_Glucan_exporter_like; cd03254 991791010845 Walker A/P-loop; other site 991791010846 ATP binding site [chemical binding]; other site 991791010847 Q-loop/lid; other site 991791010848 ABC transporter signature motif; other site 991791010849 Walker B; other site 991791010850 D-loop; other site 991791010851 H-loop/switch region; other site 991791010852 Staygreen protein; Region: Staygreen; pfam12638 991791010853 Flavodoxin-like fold; Region: Flavodoxin_2; cl00438 991791010854 Transcriptional regulators [Transcription]; Region: MarR; COG1846 991791010855 MarR family; Region: MarR_2; pfam12802 991791010856 Methyltransferase domain; Region: Methyltransf_23; pfam13489 991791010857 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 991791010858 S-adenosylmethionine binding site [chemical binding]; other site 991791010859 Threonine aldolase [Amino acid transport and metabolism]; Region: GLY1; COG2008 991791010860 Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321 991791010861 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 991791010862 catalytic residue [active] 991791010863 Acyl carrier protein phosphodiesterase [Lipid metabolism]; Region: AcpD; COG1182 991791010864 NADPH-dependent FMN reductase; Region: FMN_red; pfam03358 991791010865 Na+/melibiose symporter and related transporters [Carbohydrate transport and metabolism]; Region: MelB; COG2211 991791010866 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 991791010867 Acetyltransferase (GNAT) domain; Region: Acetyltransf_3; pfam13302 991791010868 Acetyltransferase (GNAT) family; Region: Acetyltransf_1; pfam00583 991791010869 Coenzyme A binding pocket [chemical binding]; other site 991791010870 Transcriptional regulators [Transcription]; Region: RpiR; COG1737 991791010871 RpiR-like protein. RpiR contains a SIS (Sugar ISomerase) domain, which is found in many phosphosugar isomerases and phosphosugar binding proteins. In E. coli, rpiR negatively regulates the expression of rpiB gene. Both rpiB and rpiA are ribose phosphate...; Region: SIS_RpiR; cd05013 991791010872 putative active site [active] 991791010873 Phosphotransferase system IIC components, glucose/maltose/N-acetylglucosamine-specific [Carbohydrate transport and metabolism]; Region: PtsG; COG1263 991791010874 PTS system, alpha-glucoside-specific IIBC component; Region: PTS-IIBC-alpha; TIGR02005 991791010875 PTS_IIB, PTS system, glucose/sucrose specific IIB subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIB_glc; cd00212 991791010876 active site turn [active] 991791010877 phosphorylation site [posttranslational modification] 991791010878 Alpha-galactosidases/6-phospho-beta-glucosidases, family 4 of glycosyl hydrolases [Carbohydrate transport and metabolism]; Region: CelF; COG1486 991791010879 Glycoside Hydrolases Family 4; GlvA- and pagL-like glycosidases; Region: GH4_GlvA_pagL_like; cd05298 991791010880 NAD binding site [chemical binding]; other site 991791010881 sugar binding site [chemical binding]; other site 991791010882 divalent metal binding site [ion binding]; other site 991791010883 putative tetramer (dimer of dimers) interface [polypeptide binding]; other site 991791010884 dimer interface [polypeptide binding]; other site 991791010885 Phosphotransferase system IIA components [Carbohydrate transport and metabolism]; Region: NagE; COG2190 991791010886 HPr interaction site; other site 991791010887 glycerol kinase (GK) interaction site [polypeptide binding]; other site 991791010888 active site 991791010889 phosphorylation site [posttranslational modification] 991791010890 hybrid cluster protein; Provisional; Region: PRK05290 991791010891 The HCP family of iron-sulfur proteins includes hybrid cluster protein (HCP), acetyl-CoA synthase (ACS), and carbon monoxide dehydrogenase (CODH), all of which contain [Fe4-S4] metal clusters at their active sites. These proteins have a conserved...; Region: HCP_like; cl14655 991791010892 ACS interaction site; other site 991791010893 CODH interaction site; other site 991791010894 Hybrid cluster protein (HCP), formerly known as prismane, is thought to play a role in nitrogen metabolism but its specific function is unknown. HCP has three structural domains, an N-terminal alpha-helical domain, and two similar domains comprising a...; Region: HCP; cd01914 991791010895 hybrid metal cluster; other site 991791010896 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 991791010897 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 991791010898 active site 991791010899 phosphorylation site [posttranslational modification] 991791010900 intermolecular recognition site; other site 991791010901 dimerization interface [polypeptide binding]; other site 991791010902 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 991791010903 DNA binding residues [nucleotide binding] 991791010904 dimerization interface [polypeptide binding]; other site 991791010905 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: COG4585 991791010906 Histidine kinase; Region: HisKA_3; pfam07730 991791010907 MMPL family; Region: MMPL; pfam03176 991791010908 Protein export membrane protein; Region: SecD_SecF; cl14618 991791010909 MMPL family; Region: MMPL; pfam03176 991791010910 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 991791010911 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 991791010912 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 991791010913 Carbohydrate binding domain; Region: CBM_4_9; pfam02018 991791010914 Alpha-L-arabinofuranosidase [Carbohydrate transport and metabolism]; Region: AbfA; COG3534 991791010915 Alpha-L-arabinofuranosidase C-terminus; Region: Alpha-L-AF_C; smart00813 991791010916 Domain of Unknown Function (DUF1080); Region: DUF1080; pfam06439 991791010917 Alpha-L-arabinofuranosidase C-terminus; Region: Alpha-L-AF_C; cl01412 991791010918 Antirepressor regulating drug resistance, predicted signal transduction N-terminal membrane component [Transcription / Signal transduction mechanisms]; Region: MecR1; COG4219 991791010919 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 991791010920 putative DNA binding site [nucleotide binding]; other site 991791010921 putative Zn2+ binding site [ion binding]; other site 991791010922 Predicted membrane protein [Function unknown]; Region: COG4129 991791010923 Bacterial protein of unknown function (DUF939); Region: DUF939; pfam06081 991791010924 Bacterial SNF2 helicase associated; Region: SNF2_assoc; pfam08455 991791010925 SNF2 family N-terminal domain; Region: SNF2_N; pfam00176 991791010926 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 991791010927 ATP binding site [chemical binding]; other site 991791010928 putative Mg++ binding site [ion binding]; other site 991791010929 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 991791010930 nucleotide binding region [chemical binding]; other site 991791010931 ATP-binding site [chemical binding]; other site 991791010932 DNA polymerase III, alpha subunit (gram-positive type) [DNA replication, recombination, and repair]; Region: PolC; COG2176 991791010933 DNA polymerase III polC-type N-terminus; Region: DNA_pol3_alph_N; pfam11490 991791010934 polC_OBF: A subfamily of OB folds corresponding to the N-terminal OB-fold nucleic acid binding domain of Bacillus subtilis type C replicative DNA polymerase III alpha subunit (polC). Replication in B. subtilis and Staphylococcus aureus requires two...; Region: polC_OBF; cd04484 991791010935 generic binding surface II; other site 991791010936 generic binding surface I; other site 991791010937 Polymerase and Histidinol Phosphatase domain; Region: PHP; cl17102 991791010938 active site 991791010939 DEDDh 3'-5' exonuclease domain family; Region: DEDDh; cd06127 991791010940 active site 991791010941 catalytic site [active] 991791010942 substrate binding site [chemical binding]; other site 991791010943 Polymerase and Histidinol Phosphatase domain of alpha-subunit of bacterial polymerase III at PolC gene; Region: PHP_PolIIIA_POLC; cd07435 991791010944 Predicted transcriptional regulators [Transcription]; Region: SoxR; COG0789 991791010945 Helix-Turn-Helix DNA binding domain of the BltR transcription regulator; Region: HTH_BltR; cd04782 991791010946 DNA binding residues [nucleotide binding] 991791010947 dimer interface [polypeptide binding]; other site 991791010948 Transcriptional regulator, effector-binding domain/component [Transcription / Signal transduction mechanisms]; Region: COG4978 991791010949 Na+-driven multidrug efflux pump [Defense mechanisms]; Region: NorM; COG0534 991791010950 Subfamily of the multidrug and toxic compound extrusion (MATE)-like proteins similar to Thermotoga marina NorM; Region: MATE_NorM_like; cd13137 991791010951 hypothetical protein; Provisional; Region: PRK10281 991791010952 Predicted dithiol-disulfide isomerase involved in polyketide biosynthesis [Secondary metabolites biosynthesis, transport, and catabolism]; Region: FrnE; COG2761 991791010953 DsbA family, FrnE subfamily; FrnE is a DsbA-like protein containing a CXXC motif. It is presumed to be a thiol oxidoreductase involved in polyketide biosynthesis, specifically in the production of the aromatic antibiotics frenolicin and nanaomycins; Region: DsbA_FrnE; cd03024 991791010954 catalytic residues [active] 991791010955 Members of the SGNH-hydrolase superfamily, a diverse family of lipases and esterases. The tertiary fold of the enzyme is substantially different from that of the alpha/beta hydrolase family and unique among all known hydrolases; its active site closely...; Region: SGNH_hydrolase_like_4; cd04501 991791010956 active site 991791010957 catalytic triad [active] 991791010958 oxyanion hole [active] 991791010959 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 991791010960 binding surface 991791010961 TPR motif; other site 991791010962 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 991791010963 binding surface 991791010964 TPR repeat; Region: TPR_11; pfam13414 991791010965 TPR motif; other site 991791010966 TPR repeat; Region: TPR_11; pfam13414 991791010967 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 991791010968 binding surface 991791010969 TPR repeat; Region: TPR_11; pfam13414 991791010970 TPR motif; other site 991791010971 Domain of unknown function (DUF2935); Region: DUF2935; pfam11155 991791010972 Domain of unknown function (DUF2935); Region: DUF2935; pfam11155 991791010973 Na+/melibiose symporter and related transporters [Carbohydrate transport and metabolism]; Region: MelB; COG2211 991791010974 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 991791010975 Beta-xylosidase [Carbohydrate transport and metabolism]; Region: XynB; COG3507 991791010976 Glycosyl hydrolase family 43, beta-D-xylosidase; Region: GH43_XYL_1; cd09000 991791010977 inhibitor binding site; inhibition site 991791010978 active site 991791010979 amino acid permease (yeast); Region: 2A0310; TIGR00913 991791010980 tRNA-dihydrouridine synthase [Translation, ribosomal structure and biogenesis]; Region: COG0042 991791010981 Dihydrouridine synthase-like (DUS-like) FMN-binding domain. Members of this family catalyze the reduction of the 5,6-double bond of a uridine residue on tRNA. Dihydrouridine modification of tRNA is widely observed in prokaryotes and eukaryotes, and also...; Region: DUS_like_FMN; cd02801 991791010982 FMN binding site [chemical binding]; other site 991791010983 active site 991791010984 catalytic residues [active] 991791010985 substrate binding site [chemical binding]; other site 991791010986 Uncharacterized conserved protein [Function unknown]; Region: COG3543 991791010987 Uncharacterized conserved protein [General function prediction only]; Region: BioY; COG1268 991791010988 BNR repeat-like domain; Region: BNR_2; pfam13088 991791010989 Helix-Turn-Helix DNA binding domain of transcription regulators from the MerR superfamily; Region: HTH_MerR-SF; cl02600 991791010990 MerR HTH family regulatory protein; Region: MerR_1; pfam13411 991791010991 DNA binding residues [nucleotide binding] 991791010992 Tubulin/FtsZ: Family includes tubulin alpha-, beta-, gamma-, delta-, and epsilon-tubulins as well as FtsZ, all of which are involved in polymer formation. Tubulin is the major component of microtubules, but also exists as a heterodimer and as a curved...; Region: Tubulin_FtsZ; cl10017 991791010993 nucleotide binding site [chemical binding]; other site 991791010994 V-type ATP synthase subunit I; Validated; Region: PRK05771 991791010995 3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05653 991791010996 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 991791010997 NAD(P) binding site [chemical binding]; other site 991791010998 active site 991791010999 potential frameshift: common BLAST hit: gi|300854979|ref|YP_003779963.1| Fe-S cluster protein 991791011000 Uncharacterized Fe-S center protein [General function prediction only]; Region: COG2768 991791011001 Uncharacterized Fe-S center protein [General function prediction only]; Region: COG2768 991791011002 Nicotinamidase_ related amidohydrolases. Cysteine hydrolases of unknown function that share the catalytic triad with other amidohydrolases, like nicotinamidase, which converts nicotinamide to nicotinic acid and ammonia; Region: nicotinamidase_related; cd01014 991791011003 Isochorismatase family; Region: Isochorismatase; pfam00857 991791011004 catalytic triad [active] 991791011005 conserved cis-peptide bond; other site 991791011006 Transcriptional regulator [Transcription]; Region: LysR; COG0583 991791011007 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 991791011008 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cd05466 991791011009 dimerization interface [polypeptide binding]; other site 991791011010 Escherichia coli PhnB and similar proteins; the E. coli phnB gene is found next to an operon involved in the cleavage of carbon-phosphorus bonds in unactivated alkylphosphonates; Region: PhnB_like; cd06588 991791011011 dimer interface [polypeptide binding]; other site 991791011012 Escherichia coli PhnB and similar proteins; the E. coli phnB gene is found next to an operon involved in the cleavage of carbon-phosphorus bonds in unactivated alkylphosphonates; Region: PhnB_like; cd06588 991791011013 dimer interface [polypeptide binding]; other site 991791011014 Nuclease subunit of the excinuclease complex [DNA replication, recombination, and repair]; Region: UvrC; COG0322 991791011015 Catalytic GIY-YIG domain of nucleotide excision repair endonucleases UvrC, Cho, and similar proteins; Region: GIY-YIG_UvrC_Cho; cd10434 991791011016 GIY-YIG motif/motif A; other site 991791011017 active site 991791011018 catalytic site [active] 991791011019 putative DNA binding site [nucleotide binding]; other site 991791011020 metal binding site [ion binding]; metal-binding site 991791011021 UvrB/uvrC motif; Region: UVR; pfam02151 991791011022 Endoglucanase [Carbohydrate transport and metabolism]; Region: BglC; COG2730 991791011023 Cellulase (glycosyl hydrolase family 5); Region: Cellulase; pfam00150 991791011024 guanosine 5'-monophosphate oxidoreductase; Provisional; Region: PRK05458 991791011025 IMPDH: The catalytic domain of the inosine monophosphate dehydrogenase. IMPDH catalyzes the NAD-dependent oxidation of inosine 5'-monophosphate (IMP) to xanthosine 5' monophosphate (XMP). It is a rate-limiting step in the de novo synthesis of...; Region: IMPDH; cd00381 991791011026 active site 991791011027 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 991791011028 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 991791011029 non-specific DNA binding site [nucleotide binding]; other site 991791011030 salt bridge; other site 991791011031 sequence-specific DNA binding site [nucleotide binding]; other site 991791011032 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 991791011033 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 991791011034 Tetracyclin repressor, C-terminal all-alpha domain; Region: TetR_C; pfam02909 991791011035 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 991791011036 drug resistance transporter, EmrB/QacA subfamily; Region: efflux_EmrB; TIGR00711 991791011037 putative substrate translocation pore; other site 991791011038 Predicted transcriptional regulators [Transcription]; Region: SoxR; COG0789 991791011039 Helix-Turn-Helix DNA binding domain of the transcription regulators TipAL, Mta, and SkgA; Region: HTH_TipAL-Mta; cd01106 991791011040 DNA binding residues [nucleotide binding] 991791011041 dimer interface [polypeptide binding]; other site 991791011042 TipAS antibiotic-recognition domain; Region: TipAS; pfam07739 991791011043 Four helix bundle sensory module for signal transduction; Region: 4HB_MCP_1; pfam12729 991791011044 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 991791011045 Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer); Region: MA; smart00283 991791011046 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 991791011047 dimer interface [polypeptide binding]; other site 991791011048 putative CheW interface [polypeptide binding]; other site 991791011049 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 991791011050 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cl17736 991791011051 dimerization interface [polypeptide binding]; other site 991791011052 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 991791011053 DNA binding site [nucleotide binding] 991791011054 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 991791011055 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 991791011056 Arabinose efflux permease [Carbohydrate transport and metabolism]; Region: AraJ; COG2814 991791011057 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 991791011058 putative substrate translocation pore; other site 991791011059 RPB11 and RPB3 subunits of RNA polymerase; Region: RNAP_RPB11_RPB3; cl11409 991791011060 4Fe-4S dicluster domain; Region: Fer4_9; pfam13187 991791011061 Nitroreductase family. Members of this family utilize FMN as a cofactor. This family is involved in the reduction of flavin or nitroaromatic compounds by using NAD(P)H as electron donor in a obligatory two-electron transfer. Nitrogenase is homodimer; Region: NADH_nitroreductase; cd02143 991791011062 putative FMN binding site [chemical binding]; other site 991791011063 short chain dehydrogenase; Provisional; Region: PRK06197 991791011064 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 991791011065 NAD(P) binding site [chemical binding]; other site 991791011066 active site 991791011067 helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347 991791011068 MarR family; Region: MarR; pfam01047 991791011069 Multimeric flavodoxin WrbA [General function prediction only]; Region: WrbA; COG0655 991791011070 NADPH-dependent FMN reductase; Region: FMN_red; pfam03358 991791011071 Predicted transcriptional regulators [Transcription]; Region: COG1733 991791011072 HxlR-like helix-turn-helix; Region: HxlR; pfam01638 991791011073 Predicted transcriptional regulators [Transcription]; Region: COG1733 991791011074 HxlR-like helix-turn-helix; Region: HxlR; pfam01638 991791011075 DNA gyrase inhibitor [DNA replication, recombination, and repair]; Region: COG3449 991791011076 Uncharacterized stress protein (general stress protein 26) [General function prediction only]; Region: COG3871 991791011077 Pyridoxamine 5'-phosphate oxidase; Region: Pyridox_oxidase; pfam01243 991791011078 DNA repair photolyase [DNA replication, recombination, and repair]; Region: SplB; COG1533 991791011079 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 991791011080 FeS/SAM binding site; other site 991791011081 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3708 991791011082 Predicted transcriptional regulator [Transcription]; Region: COG2378 991791011083 HTH domain; Region: HTH_11; pfam08279 991791011084 WYL domain; Region: WYL; pfam13280 991791011085 Multimeric flavodoxin WrbA [General function prediction only]; Region: WrbA; COG0655 991791011086 NADPH-dependent FMN reductase; Region: FMN_red; pfam03358 991791011087 Predicted transcriptional regulators [Transcription]; Region: COG1733 991791011088 HxlR-like helix-turn-helix; Region: HxlR; pfam01638 991791011089 Fructoselysine kinase-like. Fructoselysine is a fructoseamine formed by glycation, a non-enzymatic reaction of glucose with a primary amine followed by an Amadori rearrangement, resulting in a protein that is modified at the amino terminus and at the...; Region: Fructoselysine_kinase_like; cd01940 991791011090 Sugar kinases, ribokinase family [Carbohydrate transport and metabolism]; Region: RbsK; COG0524 991791011091 substrate binding site [chemical binding]; other site 991791011092 ATP binding site [chemical binding]; other site 991791011093 Sugar phosphate isomerases/epimerases [Carbohydrate transport and metabolism]; Region: IolE; COG1082 991791011094 AP endonuclease family 2; These endonucleases play a role in DNA repair. Cleave phosphodiester bonds at apurinic or apyrimidinic sites; the alignment also contains hexulose-6-phosphate isomerases, enzymes that catalyze the epimerization of...; Region: AP2Ec; cl12060 991791011095 AP (apurinic/apyrimidinic) site pocket; other site 991791011096 Metal-binding active site; metal-binding site 991791011097 Anaerobic C4-dicarboxylate transporter [General function prediction only]; Region: DcuB; COG2704 991791011098 anaerobic C4-dicarboxylate transporter; Reviewed; Region: PRK09412 991791011099 Predicted phosphosugar isomerases [Cell envelope biogenesis, outer membrane]; Region: AgaS; COG2222 991791011100 A subgroup of the SIS domain. SIS (Sugar ISomerase) domains are found in many phosphosugar isomerases and phosphosugar binding proteins. SIS domains are also found in proteins that regulate the expression of genes involved in synthesis of phosphosugars; Region: SIS_1; cd05710 991791011101 putative active site [active] 991791011102 SIS (Sugar ISomerase) domain repeat 2 found in Glucosamine 6-phosphate synthase (GlmS) and Glucosamine-6-phosphate deaminase (GlmD). The SIS domain is found in many phosphosugar isomerases and phosphosugar binding proteins. GlmS contains a N-terminal...; Region: SIS_GlmS_GlmD_2; cd05009 991791011103 dimer interface [polypeptide binding]; other site 991791011104 active site 991791011105 Transcriptional regulators [Transcription]; Region: PhnF; COG2188 991791011106 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 991791011107 DNA-binding site [nucleotide binding]; DNA binding site 991791011108 UTRA domain; Region: UTRA; pfam07702 991791011109 aldehyde reductase, extended (e) SDRs; Region: AR_SDR_e; cd05227 991791011110 Nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: WcaG; COG0451 991791011111 NADP binding site [chemical binding]; other site 991791011112 putative substrate binding site [chemical binding]; other site 991791011113 active site 991791011114 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 991791011115 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 991791011116 Multimeric flavodoxin WrbA [General function prediction only]; Region: WrbA; COG0655 991791011117 NADPH-dependent FMN reductase; Region: FMN_red; pfam03358 991791011118 Arabinose efflux permease [Carbohydrate transport and metabolism]; Region: AraJ; COG2814 991791011119 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 991791011120 putative substrate translocation pore; other site 991791011121 Predicted transcriptional regulators [Transcription]; Region: SoxR; COG0789 991791011122 Helix-Turn-Helix DNA binding domain of the MerR-like transcription regulators YyaN and YraB; Region: HTH_YyaN; cd01109 991791011123 DNA binding residues [nucleotide binding] 991791011124 putative dimer interface [polypeptide binding]; other site 991791011125 Predicted aminopeptidases [General function prediction only]; Region: Iap; COG2234 991791011126 M28 Zn-peptidases include aminopeptidases and carboxypeptidases; Region: M28; cd02690 991791011127 metal binding site [ion binding]; metal-binding site 991791011128 Predicted transcriptional regulators [Transcription]; Region: SoxR; COG0789 991791011129 First Helix-Turn-Helix DNA binding domain of the regulatory protein TioE; Region: HTH_TioE_rpt1; cd04772 991791011130 DNA binding residues [nucleotide binding] 991791011131 putative dimer interface [polypeptide binding]; other site 991791011132 MerR HTH family regulatory protein; Region: MerR_1; pfam13411 991791011133 Helix-Turn-Helix DNA binding domain of transcription regulators from the MerR superfamily; Region: HTH_MerR-SF; cd04761 991791011134 DNA binding residues [nucleotide binding] 991791011135 Cache domain; Region: Cache_1; pfam02743 991791011136 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 991791011137 dimerization interface [polypeptide binding]; other site 991791011138 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 991791011139 Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer); Region: MA; smart00283 991791011140 dimer interface [polypeptide binding]; other site 991791011141 putative CheW interface [polypeptide binding]; other site 991791011142 Four helix bundle sensory module for signal transduction; Region: 4HB_MCP_1; pfam12729 991791011143 Methyl-accepting chemotaxis protein [Cell motility and secretion / Signal transduction mechanisms]; Region: Tar; COG0840 991791011144 HAMP domain; Region: HAMP; pfam00672 991791011145 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 991791011146 dimer interface [polypeptide binding]; other site 991791011147 putative CheW interface [polypeptide binding]; other site 991791011148 AraC-like ligand binding domain; Region: AraC_binding; pfam02311 991791011149 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 991791011150 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 991791011151 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 991791011152 Retron-type reverse transcriptase [DNA replication, recombination, and repair]; Region: COG3344 991791011153 RT_G2_intron: Reverse transcriptases (RTs) with group II intron origin. RT transcribes DNA using RNA as template. Proteins in this subfamily are found in bacterial and mitochondrial group II introns. Their most probable ancestor was a retrotransposable...; Region: RT_G2_intron; cd01651 991791011154 putative active site [active] 991791011155 putative NTP binding site [chemical binding]; other site 991791011156 putative nucleic acid binding site [nucleotide binding]; other site 991791011157 Group II intron, maturase-specific domain; Region: GIIM; pfam08388 991791011158 Alpha/beta hydrolase family; Region: Abhydrolase_5; pfam12695 991791011159 BAAT / Acyl-CoA thioester hydrolase C terminal; Region: BAAT_C; pfam08840 991791011160 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 991791011161 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cl01054 991791011162 dimerization interface [polypeptide binding]; other site 991791011163 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 991791011164 dimer interface [polypeptide binding]; other site 991791011165 phosphorylation site [posttranslational modification] 991791011166 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 991791011167 ATP binding site [chemical binding]; other site 991791011168 Mg2+ binding site [ion binding]; other site 991791011169 G-X-G motif; other site 991791011170 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 991791011171 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 991791011172 active site 991791011173 phosphorylation site [posttranslational modification] 991791011174 intermolecular recognition site; other site 991791011175 dimerization interface [polypeptide binding]; other site 991791011176 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 991791011177 DNA binding site [nucleotide binding] 991791011178 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 991791011179 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 991791011180 ABC-type transport system involved in multi-copper enzyme maturation, permease component [General function prediction only]; Region: NosY; COG1277 991791011181 ABC-2 family transporter protein; Region: ABC2_membrane_4; pfam12730 991791011182 ABC-type multidrug transport system, ATPase component [Defense mechanisms]; Region: CcmA; COG1131 991791011183 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 991791011184 Walker A/P-loop; other site 991791011185 ATP binding site [chemical binding]; other site 991791011186 Q-loop/lid; other site 991791011187 ABC transporter signature motif; other site 991791011188 Walker B; other site 991791011189 D-loop; other site 991791011190 H-loop/switch region; other site 991791011191 NAD+--asparagine ADP-ribosyltransferase [Signal transduction mechanisms]; Region: COG5585 991791011192 Predicted transcriptional regulator [Transcription]; Region: COG1959 991791011193 Transcriptional regulator; Region: Rrf2; pfam02082 991791011194 Pyridoxamine 5'-phosphate oxidase; Region: Pyridox_oxidase; pfam01243 991791011195 The HCP family of iron-sulfur proteins includes hybrid cluster protein (HCP), acetyl-CoA synthase (ACS), and carbon monoxide dehydrogenase (CODH), all of which contain [Fe4-S4] metal clusters at their active sites. These proteins have a conserved...; Region: HCP_like; cl14655 991791011196 4Fe-4S dicluster domain; Region: Fer4_7; pfam12838 991791011197 Protein of unknown function (DUF4238); Region: DUF4238; pfam14022 991791011198 accessory Sec system protein Asp2; Region: acc_sec_asp2; TIGR03712 991791011199 Transposase IS200 like; Region: Y1_Tnp; pfam01797 991791011200 Adenine-specific DNA methylase [DNA replication, recombination, and repair]; Region: COG0827 991791011201 Methyltransferase domain; Region: Methyltransf_26; pfam13659 991791011202 Type I restriction enzyme R protein N terminus (HSDR_N); Region: HSDR_N; pfam04313 991791011203 Type II restriction enzyme, methylase subunits [Defense mechanisms]; Region: COG1002 991791011204 Eco57I restriction-modification methylase; Region: Eco57I; pfam07669 991791011205 rRNA large subunit methyltransferase; Provisional; Region: PRK00103 991791011206 hypothetical protein; Provisional; Region: PRK05590 991791011207 SEC-C motif; Region: SEC-C; pfam02810 991791011208 Metal-dependent hydrolases of the beta-lactamase superfamily I [General function prediction only]; Region: PhnP; COG1235 991791011209 Predicted Zn-dependent hydrolases of the beta-lactamase fold [General function prediction only]; Region: COG2220 991791011210 UDP-N-acetylglucosamine 1-carboxyvinyltransferase; Region: murA; TIGR01072 991791011211 UDP-N-acetylglucosamine enolpyruvyl transferase catalyzes enolpyruvyl transfer as part of the first step in the biosynthesis of peptidoglycan, a component of the bacterial cell wall. The reaction is phosphoenolpyruvate + UDP-N-acetyl-D-glucosamine =...; Region: UdpNAET; cd01555 991791011212 hinge; other site 991791011213 active site 991791011214 Domain of Unknown Function (DUF1540); Region: DUF1540; pfam07561 991791011215 dUTPase; Region: dUTPase_2; pfam08761 991791011216 Nucleoside Triphosphate Pyrophosphohydrolase (EC 3.6.1.8) MazG-like domain found in dimeric 2-Deoxyuridine 5'-triphosphate nucleotidohydrolase and similar proteins; Region: NTP-PPase_dUTPase; cd11527 991791011217 active site 991791011218 homodimer interface [polypeptide binding]; other site 991791011219 metal binding site [ion binding]; metal-binding site 991791011220 5TMR of 5TMR-LYT; Region: 5TM-5TMR_LYT; pfam07694 991791011221 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 991791011222 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 991791011223 metal binding site [ion binding]; metal-binding site 991791011224 active site 991791011225 I-site; other site 991791011226 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 991791011227 dimer interface [polypeptide binding]; other site 991791011228 putative CheW interface [polypeptide binding]; other site 991791011229 Highly conserved protein containing a thioredoxin domain [Posttranslational modification, protein turnover, chaperones]; Region: COG1331 991791011230 TRX domain, SSP411 protein family; members of this family are highly conserved proteins present in eukaryotes, bacteria and archaea, about 600-800 amino acids in length, which contain a TRX domain with a redox active CXXC motif. The human/rat protein; Region: SSP411; cd02955 991791011231 catalytic residues [active] 991791011232 Glycine/sarcosine/betaine reductase component B subunits; Region: Gly_reductase; pfam09338 991791011233 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3238 991791011234 Zinc ribbon domain; Region: CxxC_CxxC_SSSS; pfam09723 991791011235 Subtilisin-like serine proteases [Posttranslational modification, protein turnover, chaperones]; Region: AprE; COG1404 991791011236 Peptidase domain in the S8 and S53 families; Region: Peptidases_S8_S53; cl10459 991791011237 active site 991791011238 catalytic residues [active] 991791011239 ABC-type Na+ efflux pump, permease component [Energy production and conversion / Inorganic ion transport and metabolism]; Region: NatB; COG1668 991791011240 ABC-2 family transporter protein; Region: ABC2_membrane_2; pfam12679 991791011241 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 991791011242 ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136 991791011243 Walker A/P-loop; other site 991791011244 ATP binding site [chemical binding]; other site 991791011245 Q-loop/lid; other site 991791011246 ABC transporter signature motif; other site 991791011247 Walker B; other site 991791011248 D-loop; other site 991791011249 H-loop/switch region; other site 991791011250 A subgroup of L-lactate dehydrogenases; Region: LDH_3; cd05290 991791011251 L-lactate dehydrogenase; Region: L-LDH-NAD; TIGR01771 991791011252 NAD binding site [chemical binding]; other site 991791011253 dimer interface [polypeptide binding]; other site 991791011254 tetramer (dimer of dimers) interface [polypeptide binding]; other site 991791011255 substrate binding site [chemical binding]; other site 991791011256 Transcriptional regulators [Transcription]; Region: PurR; COG1609 991791011257 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 991791011258 DNA binding site [nucleotide binding] 991791011259 domain linker motif; other site 991791011260 Ligand-binding domain of DNA transcription repressor for the hexuronate utilization operon from Bacillus species and its close homologs from other bacteria, all of which are a member of the LacI-GalR family of bacterial transcription regulators; Region: PBP1_hexuronate_repressor_like; cd06272 991791011261 putative dimerization interface [polypeptide binding]; other site 991791011262 putative ligand binding site [chemical binding]; other site 991791011263 Uncharacterized protein containing a NRPS condensation (elongation) domain [General function prediction only]; Region: COG4908 991791011264 NAD(P)H:flavin oxidoreductase-like family 2. A subfamily of the nitroreductase family containing uncharacterized proteins that are similar to nitroreductase. Nitroreductase catalyzes the reduction of nitroaromatic compounds such as nitrotoluenes; Region: NADPH_oxidoreductase_2; cd02151 991791011265 putative FMN binding site [chemical binding]; other site 991791011266 Right handed beta helix region; Region: Beta_helix; pfam13229 991791011267 Right handed beta helix region; Region: Beta_helix; pfam13229 991791011268 Membrane-fusion protein [Cell envelope biogenesis, outer membrane]; Region: AcrA; COG0845 991791011269 HlyD family secretion protein; Region: HlyD_3; pfam13437 991791011270 ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136 991791011271 ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255 991791011272 Walker A/P-loop; other site 991791011273 ATP binding site [chemical binding]; other site 991791011274 Q-loop/lid; other site 991791011275 ABC transporter signature motif; other site 991791011276 Walker B; other site 991791011277 D-loop; other site 991791011278 H-loop/switch region; other site 991791011279 MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704 991791011280 MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704 991791011281 ABC-type antimicrobial peptide transport system, permease component [Defense mechanisms]; Region: SalY; COG0577 991791011282 FtsX-like permease family; Region: FtsX; pfam02687 991791011283 tRNA nucleotidyltransferase/poly(A) polymerase [Translation, ribosomal structure and biogenesis]; Region: PcnB; COG0617 991791011284 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 991791011285 Zn2+ binding site [ion binding]; other site 991791011286 Mg2+ binding site [ion binding]; other site 991791011287 Mismatch repair ATPase (MutS family) [DNA replication, recombination, and repair]; Region: MutS; COG0249 991791011288 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 991791011289 Walker A/P-loop; other site 991791011290 ATP binding site [chemical binding]; other site 991791011291 Q-loop/lid; other site 991791011292 ABC transporter signature motif; other site 991791011293 Walker B; other site 991791011294 D-loop; other site 991791011295 H-loop/switch region; other site 991791011296 aspartyl-tRNA synthetase; Provisional; Region: aspC; PRK05159 991791011297 Asp_Lys_Asn_RS_N: N-terminal, anticodon recognition domain of class 2b aminoacyl-tRNA synthetases (aaRSs). This domain is a beta-barrel domain (OB fold) involved in binding the tRNA anticodon stem-loop. Class 2b aaRSs include the homodimeric aspartyl-; Region: Asp_Lys_Asn_RS_N; cd04100 991791011298 Dimer interface [polypeptide binding]; other site 991791011299 anticodon binding site; other site 991791011300 Asx tRNA synthetase (AspRS/AsnRS) class II core domain. Assignment to class II aminoacyl-tRNA synthetases (aaRS) based upon its structure and the presence of three characteristic sequence motifs in the core domain. This family includes AsnRS as well as...; Region: AsxRS_core; cd00776 991791011301 homodimer interface [polypeptide binding]; other site 991791011302 motif 1; other site 991791011303 motif 2; other site 991791011304 active site 991791011305 motif 3; other site 991791011306 Bacterial surface proteins containing Ig-like domains [Cell motility and secretion]; Region: COG5492 991791011307 Bacterial surface proteins containing Ig-like domains [Cell motility and secretion]; Region: COG5492 991791011308 DNA topoisomerase III; Provisional; Region: PRK07726 991791011309 TOPRIM_TopoIA_TopoIII: The topoisomerase-primase (TORPIM) domain found in members of the type IA family of DNA topoisomerases (Topo IA) similar to topoisomerase III. Type IA DNA topoisomerases remove (relax) negative supercoils in the DNA by: cleaving...; Region: TOPRIM_TopoIA_TopoIII; cd03362 991791011310 active site 991791011311 putative interdomain interaction site [polypeptide binding]; other site 991791011312 putative metal-binding site [ion binding]; other site 991791011313 putative nucleotide binding site [chemical binding]; other site 991791011314 DNA Topoisomerase, subtype IA; DNA-binding, ATP-binding and catalytic domain of bacterial DNA topoisomerases I and III, and eukaryotic DNA topoisomerase III and eubacterial and archael reverse gyrases. Topoisomerases clevage single or double stranded DNA...; Region: TOP1Ac; cd00186 991791011315 domain I; other site 991791011316 DNA binding groove [nucleotide binding] 991791011317 phosphate binding site [ion binding]; other site 991791011318 domain II; other site 991791011319 domain III; other site 991791011320 nucleotide binding site [chemical binding]; other site 991791011321 catalytic site [active] 991791011322 domain IV; other site 991791011323 acetyl-CoA carboxylase carboxyltransferase subunit alpha; Validated; Region: PRK05724 991791011324 acetyl-CoA carboxylase subunit beta; Validated; Region: PRK05654 991791011325 zinc-ribbon domain; Region: zinc_ribbon_2; pfam13240 991791011326 malonate decarboxylase subunit beta; Reviewed; Region: PRK07189; cl17682 991791011327 biotin carboxylase; Validated; Region: PRK05586 991791011328 Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289 991791011329 Carbamoyl-phosphate synthase L chain, ATP binding domain; Region: CPSase_L_D2; pfam02786 991791011330 Biotin carboxylase C-terminal domain; Region: Biotin_carb_C; smart00878 991791011331 FabZ is a 17kD beta-hydroxyacyl-acyl carrier protein (ACP) dehydratase that primarily catalyzes the dehydration of beta-hydroxyacyl-ACP to trans-2-acyl-ACP, the third step in the elongation phase of the bacterial/ plastid, type II, fatty-acid...; Region: FabZ; cd01288 991791011332 acetyl-CoA carboxylase biotin carboxyl carrier protein subunit; Validated; Region: PRK06302 991791011333 The biotinyl-domain or biotin carboxyl carrier protein (BCCP) domain is present in all biotin-dependent enzymes, such as acetyl-CoA carboxylase, pyruvate carboxylase, propionyl-CoA carboxylase, methylcrotonyl-CoA carboxylase, geranyl-CoA carboxylase; Region: biotinyl_domain; cd06850 991791011334 carboxyltransferase (CT) interaction site; other site 991791011335 biotinylation site [posttranslational modification]; other site 991791011336 beta-ketoacyl-acyl-carrier-protein synthase II; Region: fabF; TIGR03150 991791011337 Beta-ketoacyl-acyl carrier protein (ACP) synthase (KAS), type I and II. KASs are responsible for the elongation steps in fatty acid biosynthesis. KASIII catalyses the initial condensation and KAS I and II catalyze further elongation steps by Claisen...; Region: KAS_I_II; cd00834 991791011338 dimer interface [polypeptide binding]; other site 991791011339 active site 991791011340 3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05557 991791011341 beta-Keto acyl carrier protein reductase (BKR), involved in Type II FAS, classical (c) SDRs; Region: BKR_SDR_c; cd05333 991791011342 NAD(P) binding site [chemical binding]; other site 991791011343 homotetramer interface [polypeptide binding]; other site 991791011344 homodimer interface [polypeptide binding]; other site 991791011345 active site 991791011346 (acyl-carrier-protein) S-malonyltransferase [Lipid metabolism]; Region: FabD; COG0331 991791011347 malonyl CoA-acyl carrier protein transacylase; Region: fabD; TIGR00128 991791011348 putative enoyl-[acyl-carrier-protein] reductase II; Region: enACPred_II; TIGR03151 991791011349 2-Nitropropane dioxygenase (NPD), one of the nitroalkane oxidizing enzyme families, catalyzes oxidative denitrification of nitroalkanes to their corresponding carbonyl compounds and nitrites. NDP is a member of the NAD(P)H-dependent flavin oxidoreductase...; Region: NPD_like; cd04730 991791011350 FMN binding site [chemical binding]; other site 991791011351 substrate binding site [chemical binding]; other site 991791011352 putative catalytic residue [active] 991791011353 acyl carrier protein; Provisional; Region: acpP; PRK00982 991791011354 3-oxoacyl-(acyl carrier protein) synthase III; Reviewed; Region: PRK09352 991791011355 Ketoacyl-acyl carrier protein synthase III (KASIII) initiates the elongation in type II fatty acid synthase systems. It is found in bacteria and plants. Elongation of fatty acids in the type II systems occurs by Claisen condensation of malonyl-acyl...; Region: KAS_III; cd00830 991791011356 dimer interface [polypeptide binding]; other site 991791011357 active site 991791011358 CoA binding pocket [chemical binding]; other site 991791011359 helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347 991791011360 MarR family; Region: MarR_2; pfam12802 991791011361 Dioxygenases related to 2-nitropropane dioxygenase [General function prediction only]; Region: COG2070 991791011362 2-Nitropropane dioxygenase (NPD), one of the nitroalkane oxidizing enzyme families, catalyzes oxidative denitrification of nitroalkanes to their corresponding carbonyl compounds and nitrites. NDP is a member of the NAD(P)H-dependent flavin oxidoreductase...; Region: NPD_like; cd04730 991791011363 FMN binding site [chemical binding]; other site 991791011364 substrate binding site [chemical binding]; other site 991791011365 putative catalytic residue [active] 991791011366 Haloacid dehalogenase-like hydrolase; Region: HAD_2; pfam13419 991791011367 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 991791011368 motif II; other site 991791011369 MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704 991791011370 ABC-type antimicrobial peptide transport system, permease component [Defense mechanisms]; Region: SalY; COG0577 991791011371 FtsX-like permease family; Region: FtsX; pfam02687 991791011372 MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704 991791011373 ABC-type antimicrobial peptide transport system, permease component [Defense mechanisms]; Region: SalY; COG0577 991791011374 FtsX-like permease family; Region: FtsX; pfam02687 991791011375 ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136 991791011376 ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255 991791011377 Walker A/P-loop; other site 991791011378 ATP binding site [chemical binding]; other site 991791011379 Q-loop/lid; other site 991791011380 ABC transporter signature motif; other site 991791011381 Walker B; other site 991791011382 D-loop; other site 991791011383 H-loop/switch region; other site 991791011384 competence damage-inducible protein A; Provisional; Region: PRK00549 991791011385 Competence-damaged protein. CinA is the first gene in the competence- inducible (cin) operon and is thought to be specifically required at some stage in the process of transformation. This domain is closely related to a domain, found in a variety of...; Region: cinA; cd00885 991791011386 putative MPT binding site; other site 991791011387 Competence-damaged protein; Region: CinA; pfam02464 991791011388 Putative primosome component and related proteins [DNA replication, recombination, and repair]; Region: DnaD; COG3935 991791011389 Replication initiation and membrane attachment; Region: DnaB_2; pfam07261 991791011390 DnaD and phage-associated domain; Region: DnaD_dom; TIGR01446 991791011391 DNA replication protein DnaC; Validated; Region: PRK06835 991791011392 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 991791011393 Walker A motif; other site 991791011394 ATP binding site [chemical binding]; other site 991791011395 Predicted membrane protein [Function unknown]; Region: COG1511 991791011396 YhgE/Pip N-terminal domain; Region: pip_yhgE_Nterm; TIGR03061 991791011397 X-X-X-Leu-X-X-Gly heptad repeats; Region: xxxLxxG_by_4; TIGR03057 991791011398 YhgE/Pip C-terminal domain; Region: pip_yhgE_Cterm; TIGR03062 991791011399 HI0933-like protein; Region: HI0933_like; pfam03486 991791011400 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500 991791011401 Acyl-ACP thioesterase [Lipid metabolism]; Region: FatA; COG3884 991791011402 4-hydroxybenzoyl-CoA thioesterase (4HBT). Catalyzes the final step in the 4-chlorobenzoate degradation pathway in which 4-chlorobenzoate is converted to 4-hydroxybenzoate in certain soil-dwelling bacteria. 4HBT forms a homotetramer with four active sites; Region: 4HBT; cd00586 991791011403 active site 991791011404 4-hydroxybenzoyl-CoA thioesterase (4HBT). Catalyzes the final step in the 4-chlorobenzoate degradation pathway in which 4-chlorobenzoate is converted to 4-hydroxybenzoate in certain soil-dwelling bacteria. 4HBT forms a homotetramer with four active sites; Region: 4HBT; cd00586 991791011405 active site 991791011406 hybrid cluster protein-associated redox disulfide domain; Region: prismane_assoc; TIGR03980 991791011407 Adenylosuccinate synthetase (AdSS) catalyzes the first step in the de novo biosynthesis of AMP. IMP and L-aspartate are conjugated in a two-step reaction accompanied by the hydrolysis of GTP to GDP in the presence of Mg2+. In the first step, the...; Region: AdSS; cd03108 991791011408 Adenylosuccinate synthetase; Region: Adenylsucc_synt; smart00788 991791011409 GDP-binding site [chemical binding]; other site 991791011410 ACT binding site; other site 991791011411 IMP binding site; other site 991791011412 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 991791011413 This family is most closely related to the GT1 family of glycosyltransferases. UDP-glucose-diacylglycerol glucosyltransferase (UGDG; also known as 1,2-diacylglycerol 3-glucosyltransferase) catalyzes the transfer of glucose from UDP-glucose to 1; Region: GT1_UGDG_like; cd03817 991791011414 putative ADP-binding pocket [chemical binding]; other site 991791011415 Uncharacterized FAD-dependent dehydrogenases [General function prediction only]; Region: COG2509 991791011416 hydroxyglutarate oxidase; Provisional; Region: PRK11728 991791011417 CDP-alcohol phosphatidyltransferase; Region: CDP-OH_P_transf; cl00453 991791011418 Rubredoxin [Energy production and conversion]; Region: COG1773 991791011419 Rubredoxin, Small Modular nonheme iron binding domain containing a [Fe(SCys)4] center, present in rubrerythrin and nigerythrin and detected either N- or C-terminal to such proteins as flavin reductase, NAD(P)H-nitrite reductase, and...; Region: rubredoxin_SM; cd00729 991791011420 iron binding site [ion binding]; other site 991791011421 Rubrerythrin [Energy production and conversion]; Region: COG1592 991791011422 rubrerythrin-like, diiron-binding domain; Region: Rubrerythrin_like; cd01046 991791011423 diiron binding motif [ion binding]; other site 991791011424 Rubredoxin [Energy production and conversion]; Region: COG1773 991791011425 Rubredoxin, Small Modular nonheme iron binding domain containing a [Fe(SCys)4] center, present in rubrerythrin and nigerythrin and detected either N- or C-terminal to such proteins as flavin reductase, NAD(P)H-nitrite reductase, and...; Region: rubredoxin_SM; cd00729 991791011426 iron binding site [ion binding]; other site 991791011427 Rubrerythrin [Energy production and conversion]; Region: COG1592 991791011428 rubrerythrin-like, diiron-binding domain; Region: Rubrerythrin_like; cd01046 991791011429 diiron binding motif [ion binding]; other site 991791011430 Dihydrodipicolinate synthase/N-acetylneuraminate lyase [Amino acid transport and metabolism / Cell envelope biogenesis, outer membrane]; Region: DapA; COG0329 991791011431 Dihydrodipicolinate synthase (DHDPS); Region: DHDPS; cd00950 991791011432 dimer interface [polypeptide binding]; other site 991791011433 active site 991791011434 catalytic residue [active] 991791011435 ADP-ribose pyrophosphatase (ADPRase) catalyzes the hydrolysis of ADP-ribose and a variety of additional ADP-sugar conjugates to AMP and ribose-5-phosphate. Like other members of the Nudix hydrolase superfamily, it requires a divalent cation, such as Mg2+; Region: ADPRase_NUDT5; cd03424 991791011436 dimer interface [polypeptide binding]; other site 991791011437 active site 991791011438 ADP-ribose binding site [chemical binding]; other site 991791011439 nudix motif; other site 991791011440 metal binding site [ion binding]; metal-binding site 991791011441 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 991791011442 Zn2+ binding site [ion binding]; other site 991791011443 Mg2+ binding site [ion binding]; other site 991791011444 Transcriptional regulators [Transcription]; Region: FadR; COG2186 991791011445 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 991791011446 DNA-binding site [nucleotide binding]; DNA binding site 991791011447 This entry represents the C-terminal ligand binding domain of many members of the GntR family; Region: FCD; smart00895 991791011448 Dihydroxyacid dehydratase/phosphogluconate dehydratase [Amino acid transport and metabolism / Carbohydrate transport and metabolism]; Region: IlvD; COG0129 991791011449 fructuronate transporter; Provisional; Region: PRK10034; cl15264 991791011450 gluconate transporter; Region: gntP; TIGR00791 991791011451 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 991791011452 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 991791011453 Ketopantoate reductase [Coenzyme metabolism]; Region: ApbA; COG1893 991791011454 Ketopantoate reductase PanE/ApbA; Region: ApbA; pfam02558 991791011455 ABC-type multidrug transport system, ATPase component [Defense mechanisms]; Region: CcmA; COG1131 991791011456 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 991791011457 Walker A/P-loop; other site 991791011458 ATP binding site [chemical binding]; other site 991791011459 Q-loop/lid; other site 991791011460 ABC transporter signature motif; other site 991791011461 Walker B; other site 991791011462 D-loop; other site 991791011463 H-loop/switch region; other site 991791011464 ABC-2 type transporter; Region: ABC2_membrane; pfam01061 991791011465 ABC-2 family transporter protein; Region: ABC2_membrane_3; pfam12698 991791011466 ABC-type multidrug transport system, permease component [Defense mechanisms]; Region: COG0842 991791011467 ATP-dependent transcriptional regulator [Transcription]; Region: MalT; COG2909 991791011468 AAA ATPase domain; Region: AAA_16; pfam13191 991791011469 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 991791011470 dimerization interface [polypeptide binding]; other site 991791011471 DNA binding residues [nucleotide binding] 991791011472 MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704 991791011473 MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704 991791011474 ABC-type antimicrobial peptide transport system, permease component [Defense mechanisms]; Region: SalY; COG0577 991791011475 FtsX-like permease family; Region: FtsX; pfam02687 991791011476 ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136 991791011477 ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255 991791011478 Walker A/P-loop; other site 991791011479 ATP binding site [chemical binding]; other site 991791011480 Q-loop/lid; other site 991791011481 ABC transporter signature motif; other site 991791011482 Walker B; other site 991791011483 D-loop; other site 991791011484 H-loop/switch region; other site 991791011485 ABC-type polar amino acid transport system, ATPase component [Amino acid transport and metabolism]; Region: GlnQ; COG1126 991791011486 ATP-binding cassette domain of the histidine and glutamine transporters; Region: ABC_HisP_GlnQ; cd03262 991791011487 Walker A/P-loop; other site 991791011488 ATP binding site [chemical binding]; other site 991791011489 Q-loop/lid; other site 991791011490 ABC transporter signature motif; other site 991791011491 Walker B; other site 991791011492 D-loop; other site 991791011493 H-loop/switch region; other site 991791011494 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 991791011495 dimer interface [polypeptide binding]; other site 991791011496 conserved gate region; other site 991791011497 putative PBP binding loops; other site 991791011498 ABC-ATPase subunit interface; other site 991791011499 Bacterial extracellular solute-binding proteins, family 3; Region: SBP_bac_3; pfam00497 991791011500 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 991791011501 substrate binding pocket [chemical binding]; other site 991791011502 membrane-bound complex binding site; other site 991791011503 hinge residues; other site 991791011504 Ferredoxin [Energy production and conversion]; Region: Fer; COG1141 991791011505 Benzoyl-CoA reductase/2-hydroxyglutaryl-CoA dehydratase subunit, BcrC/BadD/HgdB [Amino acid transport and metabolism]; Region: HgdB; COG1775 991791011506 Activator of 2-hydroxyglutaryl-CoA dehydratase (HSP70-class ATPase domain) [Lipid metabolism]; Region: COG1924 991791011507 BadF/BadG/BcrA/BcrD ATPase family; Region: BcrAD_BadFG; cl17271 991791011508 6-pyruvoyl tetrahydropterin synthase; Region: PTPS; pfam01242 991791011509 active site 991791011510 putative 7-cyano-7-deazaguanosine (preQ0) biosynthesis protein QueE, clostridial; Region: rSAM_QueE_Clost; TIGR03963 991791011511 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 991791011512 FeS/SAM binding site; other site 991791011513 GTP cyclohydrolase I; Provisional; Region: folE; PRK09347 991791011514 GTP cyclohydrolase I; Provisional; Region: PLN03044 991791011515 active site 991791011516 tRNA(Ile)-lysidine synthase MesJ [Cell cycle control, cell division, chromosome partitioning]; Region: MesJ; COG0037 991791011517 ExsB is a transcription regulator related protein. It is a subfamily of a Adenosine nucleotide binding superfamily of proteins. This protein family is represented by a single member in nearly every completed large (> 1000 genes) prokaryotic genome. In...; Region: ExsB; cd01995 991791011518 Ligand Binding Site [chemical binding]; other site 991791011519 oligopeptide ABC transporter ATP-binding protein OppF; Provisional; Region: PRK15079 991791011520 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 991791011521 Walker A/P-loop; other site 991791011522 ATP binding site [chemical binding]; other site 991791011523 Q-loop/lid; other site 991791011524 ABC transporter signature motif; other site 991791011525 Walker B; other site 991791011526 D-loop; other site 991791011527 H-loop/switch region; other site 991791011528 oligopeptide/dipeptide ABC transporter, ATP-binding protein, C-terminal domain; Region: oligo_HPY; TIGR01727 991791011529 ABC-type dipeptide/oligopeptide/nickel transport system, ATPase component [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppD; COG0444 991791011530 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 991791011531 Walker A/P-loop; other site 991791011532 ATP binding site [chemical binding]; other site 991791011533 Q-loop/lid; other site 991791011534 ABC transporter signature motif; other site 991791011535 Walker B; other site 991791011536 D-loop; other site 991791011537 H-loop/switch region; other site 991791011538 oligopeptide/dipeptide ABC transporter, ATP-binding protein, C-terminal domain; Region: oligo_HPY; TIGR01727 991791011539 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppC; COG1173 991791011540 N-terminal TM domain of oligopeptide transport permease C; Region: OppC_N; pfam12911 991791011541 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 991791011542 dimer interface [polypeptide binding]; other site 991791011543 conserved gate region; other site 991791011544 putative PBP binding loops; other site 991791011545 ABC-ATPase subunit interface; other site 991791011546 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppB; COG0601 991791011547 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 991791011548 dimer interface [polypeptide binding]; other site 991791011549 conserved gate region; other site 991791011550 putative PBP binding loops; other site 991791011551 ABC-ATPase subunit interface; other site 991791011552 ABC-type oligopeptide transport system, periplasmic component [Amino acid transport and metabolism]; Region: OppA; COG4166 991791011553 The substrate-binding component of an ABC-type oligopetide import system contains the type 2 periplasmic binding fold; Region: PBP2_OppA; cd08504 991791011554 peptide binding site [polypeptide binding]; other site 991791011555 ABC-type oligopeptide transport system, periplasmic component [Amino acid transport and metabolism]; Region: OppA; COG4166 991791011556 The substrate-binding component of an ABC-type oligopetide import system contains the type 2 periplasmic binding fold; Region: PBP2_OppA; cd08504 991791011557 peptide binding site [polypeptide binding]; other site 991791011558 oligopeptide ABC transporter ATP-binding protein OppF; Provisional; Region: PRK15079 991791011559 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 991791011560 Walker A/P-loop; other site 991791011561 ATP binding site [chemical binding]; other site 991791011562 Q-loop/lid; other site 991791011563 ABC transporter signature motif; other site 991791011564 Walker B; other site 991791011565 D-loop; other site 991791011566 H-loop/switch region; other site 991791011567 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097 991791011568 ABC-type dipeptide/oligopeptide/nickel transport system, ATPase component [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppD; COG0444 991791011569 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 991791011570 Walker A/P-loop; other site 991791011571 ATP binding site [chemical binding]; other site 991791011572 Q-loop/lid; other site 991791011573 ABC transporter signature motif; other site 991791011574 Walker B; other site 991791011575 D-loop; other site 991791011576 H-loop/switch region; other site 991791011577 oligopeptide/dipeptide ABC transporter, ATP-binding protein, C-terminal domain; Region: oligo_HPY; TIGR01727 991791011578 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppC; COG1173 991791011579 N-terminal TM domain of oligopeptide transport permease C; Region: OppC_N; pfam12911 991791011580 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 991791011581 dimer interface [polypeptide binding]; other site 991791011582 conserved gate region; other site 991791011583 putative PBP binding loops; other site 991791011584 ABC-ATPase subunit interface; other site 991791011585 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppB; COG0601 991791011586 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 991791011587 dimer interface [polypeptide binding]; other site 991791011588 conserved gate region; other site 991791011589 putative PBP binding loops; other site 991791011590 ABC-ATPase subunit interface; other site 991791011591 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cl17200 991791011592 non-specific DNA binding site [nucleotide binding]; other site 991791011593 salt bridge; other site 991791011594 sequence-specific DNA binding site [nucleotide binding]; other site 991791011595 ABC-type oligopeptide transport system, periplasmic component [Amino acid transport and metabolism]; Region: OppA; COG4166 991791011596 The substrate-binding component of an ABC-type oligopetide import system contains the type 2 periplasmic binding fold; Region: PBP2_OppA; cd08504 991791011597 peptide binding site [polypeptide binding]; other site 991791011598 oligopeptide ABC transporter ATP-binding protein OppF; Provisional; Region: PRK15079 991791011599 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 991791011600 Walker A/P-loop; other site 991791011601 ATP binding site [chemical binding]; other site 991791011602 Q-loop/lid; other site 991791011603 ABC transporter signature motif; other site 991791011604 Walker B; other site 991791011605 D-loop; other site 991791011606 H-loop/switch region; other site 991791011607 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097 991791011608 ABC-type dipeptide/oligopeptide/nickel transport system, ATPase component [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppD; COG0444 991791011609 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 991791011610 Walker A/P-loop; other site 991791011611 ATP binding site [chemical binding]; other site 991791011612 Q-loop/lid; other site 991791011613 ABC transporter signature motif; other site 991791011614 Walker B; other site 991791011615 D-loop; other site 991791011616 H-loop/switch region; other site 991791011617 oligopeptide/dipeptide ABC transporter, ATP-binding protein, C-terminal domain; Region: oligo_HPY; TIGR01727 991791011618 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppC; COG1173 991791011619 N-terminal TM domain of oligopeptide transport permease C; Region: OppC_N; pfam12911 991791011620 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 991791011621 dimer interface [polypeptide binding]; other site 991791011622 conserved gate region; other site 991791011623 putative PBP binding loops; other site 991791011624 ABC-ATPase subunit interface; other site 991791011625 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppB; COG0601 991791011626 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 991791011627 dimer interface [polypeptide binding]; other site 991791011628 conserved gate region; other site 991791011629 putative PBP binding loops; other site 991791011630 ABC-ATPase subunit interface; other site 991791011631 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cl17200 991791011632 non-specific DNA binding site [nucleotide binding]; other site 991791011633 salt bridge; other site 991791011634 sequence-specific DNA binding site [nucleotide binding]; other site 991791011635 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 991791011636 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 991791011637 non-specific DNA binding site [nucleotide binding]; other site 991791011638 salt bridge; other site 991791011639 sequence-specific DNA binding site [nucleotide binding]; other site 991791011640 Regulators of stationary/sporulation gene expression [Transcription]; Region: AbrB; COG2002 991791011641 SpoVT / AbrB like domain; Region: SpoVT_AbrB; smart00966 991791011642 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 991791011643 Coenzyme A binding pocket [chemical binding]; other site 991791011644 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 991791011645 Acetyltransferases [General function prediction only]; Region: RimI; COG0456 991791011646 Coenzyme A binding pocket [chemical binding]; other site 991791011647 Regulators of stationary/sporulation gene expression [Transcription]; Region: AbrB; COG2002 991791011648 Antidote-toxin recognition MazE; Region: Antitoxin-MazE; pfam04014 991791011649 c-di-GMP phosphodiesterase class II (HD-GYP domain) [Signal transduction mechanisms]; Region: COG2206 991791011650 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 991791011651 Zn2+ binding site [ion binding]; other site 991791011652 Mg2+ binding site [ion binding]; other site 991791011653 Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain (MocR family) and their eukaryotic orthologs [Transcription / Amino acid transport and metabolism]; Region: ARO8; COG1167 991791011654 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 991791011655 DNA-binding site [nucleotide binding]; DNA binding site 991791011656 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 991791011657 pyridoxal 5'-phosphate binding site [chemical binding]; other site 991791011658 homodimer interface [polypeptide binding]; other site 991791011659 catalytic residue [active] 991791011660 acetolactate synthase; Reviewed; Region: PRK08322 991791011661 Pyrimidine (PYR) binding domain of POX and related proteins; Region: TPP_PYR_POX_like; cd07035 991791011662 PYR/PP interface [polypeptide binding]; other site 991791011663 dimer interface [polypeptide binding]; other site 991791011664 TPP binding site [chemical binding]; other site 991791011665 Thiamine pyrophosphate enzyme, central domain; Region: TPP_enzyme_M; pfam00205 991791011666 Thiamine pyrophosphate (TPP) family, Acetolactate synthase (ALS) subfamily, TPP-binding module; composed of proteins similar to Klebsiella pneumoniae ALS, a catabolic enzyme required for butanediol fermentation. ALS catalyzes the conversion of 2...; Region: TPP_ALS; cd02010 991791011667 TPP-binding site [chemical binding]; other site 991791011668 dimer interface [polypeptide binding]; other site 991791011669 Heavy-metal-associated domain (HMA) is a conserved domain of approximately 30 amino acid residues found in a number of proteins that transport or detoxify heavy metals, for example, the CPx-type heavy metal ATPases and copper chaperones. HMA domain...; Region: HMA; cd00371 991791011670 metal-binding site [ion binding] 991791011671 Cation transport ATPase [Inorganic ion transport and metabolism]; Region: ZntA; COG2217 991791011672 Heavy-metal-associated domain (HMA) is a conserved domain of approximately 30 amino acid residues found in a number of proteins that transport or detoxify heavy metals, for example, the CPx-type heavy metal ATPases and copper chaperones. HMA domain...; Region: HMA; cd00371 991791011673 metal-binding site [ion binding] 991791011674 Cation transport ATPase [Inorganic ion transport and metabolism]; Region: ZntA; COG2217 991791011675 Heavy-metal-associated domain (HMA) is a conserved domain of approximately 30 amino acid residues found in a number of proteins that transport or detoxify heavy metals, for example, the CPx-type heavy metal ATPases and copper chaperones. HMA domain...; Region: HMA; cd00371 991791011676 metal-binding site [ion binding] 991791011677 E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122 991791011678 Soluble P-type ATPase [General function prediction only]; Region: COG4087 991791011679 Uncharacterized family 2; belongs to a superfamily containing transcriptional regulators CsoR (copper-sensitive operon repressor), RcnR, and FrmR, and related domains; this family was previously known as part of DUF156; Region: CsoR-like_DUF156_2; cd10159 991791011680 putative homodimer interface [polypeptide binding]; other site 991791011681 putative homotetramer interface [polypeptide binding]; other site 991791011682 putative allosteric switch controlling residues; other site 991791011683 putative metal binding site [ion binding]; other site 991791011684 putative homodimer-homodimer interface [polypeptide binding]; other site 991791011685 NADP-dependent glyceraldehyde-3-phosphate dehydrogenase; Provisional; Region: PLN00412 991791011686 NADP+-dependent non-phosphorylating glyceraldehyde 3-phosphate dehydrogenase and ALDH family 11; Region: ALDH_F11_NP-GAPDH; cd07082 991791011687 tetrameric interface [polypeptide binding]; other site 991791011688 activator binding site; other site 991791011689 NADP binding site [chemical binding]; other site 991791011690 substrate binding site [chemical binding]; other site 991791011691 catalytic residues [active] 991791011692 Uncharacterized membrane protein [Function unknown]; Region: SapB; COG1285 991791011693 MgtC family; Region: MgtC; pfam02308 991791011694 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 991791011695 undecaprenyl phosphate 4-deoxy-4-formamido-L-arabinose transferase; Provisional; Region: PRK10714 991791011696 Bacterial DPM1_like enzymes are related to eukaryotic DPM1; Region: DPM1_like_bac; cd04187 991791011697 Ligand binding site; other site 991791011698 Putative Catalytic site; other site 991791011699 DXD motif; other site 991791011700 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 991791011701 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 991791011702 dimerization interface [polypeptide binding]; other site 991791011703 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 991791011704 dimer interface [polypeptide binding]; other site 991791011705 phosphorylation site [posttranslational modification] 991791011706 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 991791011707 ATP binding site [chemical binding]; other site 991791011708 Mg2+ binding site [ion binding]; other site 991791011709 G-X-G motif; other site 991791011710 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 991791011711 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 991791011712 active site 991791011713 phosphorylation site [posttranslational modification] 991791011714 intermolecular recognition site; other site 991791011715 dimerization interface [polypeptide binding]; other site 991791011716 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 991791011717 DNA binding site [nucleotide binding] 991791011718 Flavodoxin-like fold; Region: Flavodoxin_2; cl00438 991791011719 Alpha/beta hydrolase family; Region: Abhydrolase_5; pfam12695 991791011720 Prolyl oligopeptidase family; Region: Peptidase_S9; pfam00326 991791011721 Membrane transporters of cations and cationic drugs [Inorganic ion transport and metabolism]; Region: EmrE; COG2076 991791011722 helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347 991791011723 MarR family; Region: MarR; pfam01047 991791011724 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 991791011725 Major Facilitator Superfamily; Region: MFS_1; pfam07690 991791011726 putative substrate translocation pore; other site 991791011727 Transcriptional regulators [Transcription]; Region: MarR; COG1846 991791011728 MarR family; Region: MarR_2; pfam12802 991791011729 ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395 991791011730 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 991791011731 dimer interface [polypeptide binding]; other site 991791011732 conserved gate region; other site 991791011733 putative PBP binding loops; other site 991791011734 ABC-ATPase subunit interface; other site 991791011735 ABC-type polysaccharide transport system, permease component [Carbohydrate transport and metabolism]; Region: LplB; COG4209 991791011736 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 991791011737 dimer interface [polypeptide binding]; other site 991791011738 conserved gate region; other site 991791011739 putative PBP binding loops; other site 991791011740 ABC-ATPase subunit interface; other site 991791011741 ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653 991791011742 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; pfam01547 991791011743 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 991791011744 putative DNA binding site [nucleotide binding]; other site 991791011745 putative Zn2+ binding site [ion binding]; other site 991791011746 Transcriptional regulator/sugar kinase [Transcription / Carbohydrate transport and metabolism]; Region: NagC; COG1940 991791011747 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cl17037 991791011748 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cl17037 991791011749 FOG: CBS domain [General function prediction only]; Region: COG0517 991791011750 The CBS domain, named after human CBS, is a small domain originally identified in cystathionine beta-synthase and is subsequently found in a wide range of different proteins. CBS domains usually occur in tandem repeats. They associate to form a so-called...; Region: CBS_pair_30; cd04643 991791011751 DNA polymerase III subunit beta; Validated; Region: PRK06673 991791011752 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3786 991791011753 DNA-binding transcriptional activator KdpE; Provisional; Region: PRK10529 991791011754 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 991791011755 active site 991791011756 phosphorylation site [posttranslational modification] 991791011757 intermolecular recognition site; other site 991791011758 dimerization interface [polypeptide binding]; other site 991791011759 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 991791011760 DNA binding site [nucleotide binding] 991791011761 Osmosensitive K+ channel histidine kinase [Signal transduction mechanisms]; Region: KdpD; COG2205 991791011762 Osmosensitive K+ channel His kinase sensor domain; Region: KdpD; pfam02702 991791011763 USP domain is located between the N-terminal sensor domain and C-terminal catalytic domain of this Osmosensitive K+ channel histidine kinase family. The family of KdpD sensor kinase proteins regulates the kdpFABC operon responsible for potassium...; Region: USP_OKCHK; cd01987 991791011764 Ligand Binding Site [chemical binding]; other site 991791011765 Domain of unknown function (DUF4118); Region: DUF4118; pfam13493 991791011766 GAF domain; Region: GAF_3; pfam13492 991791011767 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 991791011768 phosphorylation site [posttranslational modification] 991791011769 dimer interface [polypeptide binding]; other site 991791011770 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 991791011771 ATP binding site [chemical binding]; other site 991791011772 Mg2+ binding site [ion binding]; other site 991791011773 G-X-G motif; other site 991791011774 potassium-transporting ATPase subunit C; Provisional; Region: PRK13995 991791011775 potassium-transporting ATPase subunit B; Provisional; Region: PRK01122 991791011776 E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122 991791011777 Soluble P-type ATPase [General function prediction only]; Region: COG4087 991791011778 K+-transporting ATPase, A chain [Inorganic ion transport and metabolism]; Region: KdpA; COG2060 991791011779 NTF2-like N-terminal transpeptidase domain; Region: MecA_N; pfam05223 991791011780 penicillin-binding protein 2; Region: pbp2_mrdA; TIGR03423 991791011781 Penicillin-binding Protein dimerisation domain; Region: PBP_dimer; pfam03717 991791011782 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; pfam00905 991791011783 Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all...; Region: FN3; cd00063 991791011784 Endopygalactorunase [Cell envelope biogenesis, outer membrane]; Region: PGU1; COG5434 991791011785 Cytokine receptor motif; other site 991791011786 Probable polygalacturonase At3g15720; Region: PLN03003; cl14103 991791011787 Zn-dependent hydrolases, including glyoxylases [General function prediction only]; Region: GloB; COG0491 991791011788 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 991791011789 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 991791011790 HAMP domain; Region: HAMP; pfam00672 991791011791 dimerization interface [polypeptide binding]; other site 991791011792 Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer); Region: MA; smart00283 991791011793 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 991791011794 dimer interface [polypeptide binding]; other site 991791011795 putative CheW interface [polypeptide binding]; other site 991791011796 Escherichia coli PhnB and similar proteins; the E. coli phnB gene is found next to an operon involved in the cleavage of carbon-phosphorus bonds in unactivated alkylphosphonates; Region: PhnB_like; cd06588 991791011797 dimer interface [polypeptide binding]; other site 991791011798 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 991791011799 Putative hydrophobic ligand-binding SRPBCC domain of an uncharacterized subgroup of CalC- and Aha1-like proteins; Region: SRPBCC_CalC_Aha1-like_4; cd08897 991791011800 putative hydrophobic ligand binding site [chemical binding]; other site 991791011801 Chagasin family peptidase inhibitor I42; Region: Inhibitor_I42; pfam09394 991791011802 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 991791011803 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 991791011804 non-specific DNA binding site [nucleotide binding]; other site 991791011805 salt bridge; other site 991791011806 sequence-specific DNA binding site [nucleotide binding]; other site 991791011807 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 991791011808 binding surface 991791011809 Tetratricopeptide repeat; Region: TPR_12; pfam13424 991791011810 TPR motif; other site 991791011811 Tetratricopeptide repeat; Region: TPR_12; pfam13424 991791011812 Predicted membrane protein [Function unknown]; Region: COG1511 991791011813 YhgE/Pip N-terminal domain; Region: pip_yhgE_Nterm; TIGR03061 991791011814 SUKH-3 immunity protein; Region: SUKH-3; pfam14433 991791011815 YwqJ-like deaminase; Region: YwqJ-deaminase; pfam14431 991791011816 SUKH-3 immunity protein; Region: SUKH-3; pfam14433 991791011817 NAD+--asparagine ADP-ribosyltransferase [Signal transduction mechanisms]; Region: COG5585 991791011818 SUKH-3 immunity protein; Region: SUKH-3; pfam14433 991791011819 NAD+--asparagine ADP-ribosyltransferase [Signal transduction mechanisms]; Region: COG5585 991791011820 YwqJ-like deaminase; Region: YwqJ-deaminase; pfam14431 991791011821 LXG domain of WXG superfamily; Region: LXG; pfam04740 991791011822 NAD+--asparagine ADP-ribosyltransferase [Signal transduction mechanisms]; Region: COG5585 991791011823 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4495 991791011824 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4495 991791011825 type VII secretion protein EssC, C-terminal domain; Region: T7_EssCb_Firm; TIGR03928 991791011826 FtsK/SpoIIIE family; Region: FtsK_SpoIIIE; pfam01580 991791011827 FtsK/SpoIIIE family; Region: FtsK_SpoIIIE; pfam01580 991791011828 Predicted membrane protein [Function unknown]; Region: COG4499 991791011829 type VII secretion protein EssB; Region: T7_EssB; TIGR03926 991791011830 WXG100 protein secretion system (Wss), protein YukD; Region: YukD; pfam08817 991791011831 type VII secretion protein EssA; Region: T7SS_EssA_Firm; TIGR03927 991791011832 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4842 991791011833 Molecular chaperone (small heat shock protein) [Posttranslational modification, protein turnover, chaperones]; Region: IbpA; COG0071 991791011834 Group of bacterial proteins containing an alpha crystallin domain (ACD) similar to Lactobacillus plantarum (Lp) small heat shock proteins (sHsp) HSP 18.5, HSP 18.55 and HSP 19.3. sHsps are molecular chaperones that suppress protein aggregation and...; Region: ACD_LpsHSP_like; cd06471 991791011835 putative dimer interface [polypeptide binding]; other site 991791011836 replicative DNA helicase; Provisional; Region: PRK05595 991791011837 DnaB-like helicase N terminal domain; Region: DnaB; pfam00772 991791011838 DnaB helicase C terminal domain. The hexameric helicase DnaB unwinds the DNA duplex at the chromosome replication fork. Although the mechanism by which DnaB both couples ATP hydrolysis to translocation along DNA and denatures the duplex is unknown, a...; Region: DnaB_C; cd00984 991791011839 Walker A motif; other site 991791011840 ATP binding site [chemical binding]; other site 991791011841 Walker B motif; other site 991791011842 DNA binding loops [nucleotide binding] 991791011843 ATP-dependent protease, Lon family; Region: spore_lon_C; TIGR02903 991791011844 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 991791011845 Walker A motif; other site 991791011846 ATP binding site [chemical binding]; other site 991791011847 Walker B motif; other site 991791011848 arginine finger; other site 991791011849 Lon protease (S16) C-terminal proteolytic domain; Region: Lon_C; pfam05362 991791011850 50S ribosomal protein L9; Reviewed; Region: rplI; PRK00137 991791011851 Ribosomal protein L9, N-terminal domain; Region: Ribosomal_L9_N; pfam01281 991791011852 Ribosomal protein L9, C-terminal domain; Region: Ribosomal_L9_C; pfam03948 991791011853 Predicted signaling protein consisting of a modified GGDEF domain and a DHH domain [Signal transduction mechanisms]; Region: COG3887 991791011854 PAS domain; Region: PAS; smart00091 991791011855 putative active site [active] 991791011856 heme pocket [chemical binding]; other site 991791011857 DHH family; Region: DHH; pfam01368 991791011858 DHHA1 domain; Region: DHHA1; pfam02272 991791011859 Predicted membrane protein [Function unknown]; Region: COG4241 991791011860 MazG-like family; Region: MazG-like; pfam12643 991791011861 30S ribosomal protein S18; Reviewed; Region: rpsR; PRK00391 991791011862 Single-stranded DNA-binding protein [DNA replication, recombination, and repair]; Region: Ssb; COG0629 991791011863 SSB_OBF: A subfamily of OB folds similar to the OB fold of ssDNA-binding protein (SSB). SSBs bind with high affinity to ssDNA. They bind to and protect ssDNA intermediates during DNA metabolic pathways. All bacterial and eukaryotic SSBs studied to date...; Region: SSB_OBF; cd04496 991791011864 dimer interface [polypeptide binding]; other site 991791011865 ssDNA binding site [nucleotide binding]; other site 991791011866 tetramer (dimer of dimers) interface [polypeptide binding]; other site 991791011867 30S ribosomal protein S6; Reviewed; Region: rpsF; PRK00453 991791011868 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4481 991791011869 Small-conductance mechanosensitive channel [Cell envelope biogenesis, outer membrane]; Region: MscS; COG0668 991791011870 Mechanosensitive ion channel; Region: MS_channel; pfam00924 991791011871 putative sporulation protein YyaC; Region: spore_YyaC; TIGR02841 991791011872 ParB-like nuclease domain; Region: ParB; smart00470 991791011873 ParB/RepB/Spo0J family partition protein; Region: parB_part; TIGR00180 991791011874 ATPases involved in chromosome partitioning [Cell division and chromosome partitioning]; Region: Soj; COG1192 991791011875 ParA and ParB of Caulobacter crescentus belong to a conserved family of bacterial proteins implicated in chromosome segregation. ParB binds to DNA sequences adjacent to the origin of replication and localizes to opposite cell poles shortly following the...; Region: ParA; cd02042 991791011876 P-loop; other site 991791011877 Magnesium ion binding site [ion binding]; other site 991791011878 ParA and ParB of Caulobacter crescentus belong to a conserved family of bacterial proteins implicated in chromosome segregation. ParB binds to DNA sequences adjacent to the origin of replication and localizes to opposite cell poles shortly following the...; Region: ParA; cd02042 991791011879 Magnesium ion binding site [ion binding]; other site 991791011880 nucleoid occlusion protein; Region: nucleoid_noc; TIGR04285 991791011881 ParB-like nuclease domain; Region: ParBc; pfam02195 991791011882 Predicted S-adenosylmethionine-dependent methyltransferase involved in bacterial cell division [Cell envelope biogenesis, outer membrane]; Region: GidB; COG0357 991791011883 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 991791011884 S-adenosylmethionine binding site [chemical binding]; other site 991791011885 tRNA uridine 5-carboxymethylaminomethyl modification enzyme GidA; Validated; Region: PRK05192 991791011886 Anaerobic glycerol-3-phosphate dehydrogenase [Amino acid transport and metabolism]; Region: GlpB; cl17730 991791011887 tRNA (uracil-5-)-methyltransferase Gid; Reviewed; Region: PRK05335 991791011888 GidA associated domain 3; Region: GIDA_assoc_3; pfam13932 991791011889 tRNA modification GTPase TrmE; Reviewed; Region: trmE; PRK05291 991791011890 GTP-binding protein TrmE N-terminus; Region: TrmE_N; pfam10396 991791011891 trmE is a tRNA modification GTPase; Region: trmE; cd04164 991791011892 G1 box; other site 991791011893 GTP/Mg2+ binding site [chemical binding]; other site 991791011894 Switch I region; other site 991791011895 G2 box; other site 991791011896 Switch II region; other site 991791011897 G3 box; other site 991791011898 G4 box; other site 991791011899 G5 box; other site 991791011900 Catalytic cysteine-containing C-terminus of GTPase, MnmE; Region: GTPase_Cys_C; pfam12631 991791011901 Predicted RNA-binding protein [General function prediction only]; Region: Jag; COG1847 991791011902 jag_K homology RNA-binding domain. The KH domain is found in proteins homologous to the Bacillus subtilis protein Jag, which is associated with SpoIIIJ and is necessary for the third stage of sporulation. The KH motif is a beta-alpha-alpha-beta-beta...; Region: jag_KH; cd02414 991791011903 G-X-X-G motif; other site 991791011904 R3H domain found in proteins homologous to Bacillus subtilus Jag, which is associated with SpoIIIJ. SpoIIIJ is necessary for the third stage of sporulation. The name of the R3H domain comes from the characteristic spacing of the most conserved arginine...; Region: R3H_jag; cd02644 991791011905 RxxxH motif; other site 991791011906 Preprotein translocase subunit YidC [Intracellular trafficking and secretion]; Region: YidC; COG0706 991791011907 putative inner membrane protein translocase component YidC; Provisional; Region: PRK00145 991791011908 Haemolytic domain; Region: Haemolytic; pfam01809 991791011909 ribonuclease P; Reviewed; Region: rnpA; PRK00499 991791011910 Ribosomal protein L34; Region: Ribosomal_L34; cl00370 991791011911 Initiator Replication protein; Region: Rep_3; pfam01051 991791011912 Peptidase_C39 like family; Region: Peptidase_C39_2; pfam13529 991791011913 putative active site [active] 991791011914 Site-specific recombinases, DNA invertase Pin homologs [DNA replication, recombination, and repair]; Region: PinR; COG1961 991791011915 Serine Recombinase (SR) family, Resolvase and Invertase subfamily, catalytic domain; members contain a C-terminal DNA binding domain. Serine recombinases catalyze site-specific recombination of DNA molecules by a concerted, four-strand cleavage and...; Region: SR_ResInv; cd03768 991791011916 catalytic residues [active] 991791011917 catalytic nucleophile [active] 991791011918 Presynaptic Site I dimer interface [polypeptide binding]; other site 991791011919 Synaptic Antiparallel dimer interface [polypeptide binding]; other site 991791011920 Synaptic Flat tetramer interface [polypeptide binding]; other site 991791011921 Synaptic Site I dimer interface [polypeptide binding]; other site 991791011922 DNA binding site [nucleotide binding]