-- dump date 20140619_042346 -- class Genbank::misc_feature -- table misc_feature_note -- id note 272562000001 Short-chain dehydrogenases of various substrate specificities [General function prediction only]; Region: DltE; COG0300 272562000002 classical (c) SDRs; Region: SDR_c; cd05233 272562000003 NAD(P) binding site [chemical binding]; other site 272562000004 active site 272562000005 Bacterial surface proteins containing Ig-like domains [Cell motility and secretion]; Region: COG5492 272562000006 Clostridial hydrophobic, with a conserved W residue, domain; Region: ChW; smart00728 272562000007 Clostridial hydrophobic, with a conserved W residue, domain; Region: ChW; smart00728 272562000008 Clostridial hydrophobic, with a conserved W residue, domain; Region: ChW; smart00728 272562000009 Bacterial Ig-like domain (group 2); Region: Big_2; pfam02368 272562000010 Bacterial surface proteins containing Ig-like domains [Cell motility and secretion]; Region: COG5492 272562000011 Clostridial hydrophobic, with a conserved W residue, domain; Region: ChW; smart00728 272562000012 Clostridial hydrophobic, with a conserved W residue, domain; Region: ChW; smart00728 272562000013 Clostridial hydrophobic, with a conserved W residue, domain; Region: ChW; smart00728 272562000014 Bacterial Ig-like domain (group 2); Region: Big_2; pfam02368 272562000015 Uncharacterized protein involved in cytokinesis, contains TGc (transglutaminase/protease-like) domain [Cell division and chromosome partitioning]; Region: CYK3; COG5279 272562000016 Transglutaminase-like superfamily; Region: Transglut_core; pfam01841 272562000017 Bacterial surface proteins containing Ig-like domains [Cell motility and secretion]; Region: COG5492 272562000018 Clostridial hydrophobic, with a conserved W residue, domain; Region: ChW; smart00728 272562000019 Clostridial hydrophobic, with a conserved W residue, domain; Region: ChW; smart00728 272562000020 Clostridial hydrophobic, with a conserved W residue, domain; Region: ChW; smart00728 272562000021 Bacterial Ig-like domain (group 2); Region: Big_2; pfam02368 272562000022 Bacterial surface proteins containing Ig-like domains [Cell motility and secretion]; Region: COG5492 272562000023 Clostridial hydrophobic, with a conserved W residue, domain; Region: ChW; smart00728 272562000024 Clostridial hydrophobic, with a conserved W residue, domain; Region: ChW; smart00728 272562000025 Clostridial hydrophobic, with a conserved W residue, domain; Region: ChW; smart00728 272562000026 Bacterial Ig-like domain (group 2); Region: Big_2; pfam02368 272562000027 Uncharacterized protein involved in cytokinesis, contains TGc (transglutaminase/protease-like) domain [Cell division and chromosome partitioning]; Region: CYK3; COG5279 272562000028 Transglutaminase-like superfamily; Region: Transglut_core; pfam01841 272562000029 Cysteine protease [Posttranslational modification, protein turnover, chaperones]; Region: COG4870 272562000030 C1 Peptidase family (MEROPS database nomenclature), also referred to as the papain family; composed of two subfamilies of cysteine peptidases (CPs), C1A (papain) and C1B (bleomycin hydrolase). Papain-like enzymes are mostly endopeptidases with some...; Region: Peptidase_C1; cd02619 272562000031 active site 272562000032 Enterocin A Immunity; Region: EntA_Immun; pfam08951 272562000033 Transcriptional regulators [Transcription]; Region: PhnF; COG2188 272562000034 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 272562000035 DNA-binding site [nucleotide binding]; DNA binding site 272562000036 UTRA domain; Region: UTRA; pfam07702 272562000037 Response regulator containing CheY-like receiver and SARP domains [Signal transduction mechanisms]; Region: COG3947 272562000038 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cl19078 272562000039 active site 272562000040 phosphorylation site [posttranslational modification] 272562000041 dimerization interface [polypeptide binding]; other site 272562000042 Beta-glucosidase/6-phospho-beta-glucosidase/beta- galactosidase [Carbohydrate transport and metabolism]; Region: BglB; COG2723 272562000043 Glycosyl hydrolase family 1; Region: Glyco_hydro_1; pfam00232 272562000044 Enterocin A Immunity; Region: EntA_Immun; pfam08951 272562000045 Dehydrogenases (flavoproteins) [Energy production and conversion]; Region: FixC; COG0644 272562000046 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl19134 272562000047 Inositol hexakisphosphate; Region: PTPlike_phytase; pfam14566 272562000048 Glycerophosphoryl diester phosphodiesterase [Energy production and conversion]; Region: UgpQ; COG0584 272562000049 Glycerophosphodiester phosphodiesterase domain of uncharacterized bacterial glycerophosphodiester phosphodiesterases; Region: GDPD_memb_like; cd08579 272562000050 putative active site [active] 272562000051 catalytic site [active] 272562000052 putative metal binding site [ion binding]; other site 272562000053 Predicted membrane protein [Function unknown]; Region: COG4331 272562000054 spore germination protein (amino acid permease); Region: 2A0309; TIGR00912 272562000055 germination protein, Ger(x)C family; Region: spore_ger_x_C; TIGR02887 272562000056 Bacillus/Clostridium GerA spore germination protein; Region: GerA; pfam03323 272562000057 Spore germination protein; Region: Spore_permease; pfam03845 272562000058 Transcriptional regulators [Transcription]; Region: MarR; COG1846 272562000059 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cl17220 272562000060 Pyruvate decarboxylase and related thiamine pyrophosphate-requiring enzymes [Carbohydrate transport and metabolism / Coenzyme metabolism / General function prediction only]; Region: COG3961 272562000061 Pyrimidine (PYR) binding domain of pyruvate decarboxylase (PDC), indolepyruvate decarboxylase (IPDC) and related proteins; Region: TPP_PYR_PDC_IPDC_like; cd07038 272562000062 dimer interface [polypeptide binding]; other site 272562000063 PYR/PP interface [polypeptide binding]; other site 272562000064 TPP binding site [chemical binding]; other site 272562000065 Thiamine pyrophosphate enzyme, central domain; Region: TPP_enzyme_M; pfam00205 272562000066 Thiamine pyrophosphate (TPP) family, PDC_IPDC subfamily, TPP-binding module; composed of proteins similar to pyruvate decarboxylase (PDC) and indolepyruvate decarboxylase (IPDC). PDC, a key enzyme in alcoholic fermentation, catalyzes the conversion of...; Region: TPP_PDC_IPDC; cd02005 272562000067 TPP-binding site [chemical binding]; other site 272562000068 dimer interface [polypeptide binding]; other site 272562000069 Amino acid transporters [Amino acid transport and metabolism]; Region: PotE; COG0531 272562000070 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 272562000071 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 272562000072 WHG domain; Region: WHG; pfam13305 272562000073 drug efflux system protein MdtG; Provisional; Region: PRK09874 272562000074 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 272562000075 putative substrate translocation pore; other site 272562000076 Cysteine hydrolases; This family contains amidohydrolases, like CSHase (N-carbamoylsarcosine amidohydrolase), involved in creatine metabolism and nicotinamidase, converting nicotinamide to nicotinic acid and ammonia in the pyridine nucleotide cycle. It...; Region: cysteine_hydrolases; cd00431 272562000077 catalytic triad [active] 272562000078 conserved cis-peptide bond; other site 272562000079 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 272562000080 dimerization interface [polypeptide binding]; other site 272562000081 putative DNA binding site [nucleotide binding]; other site 272562000082 putative Zn2+ binding site [ion binding]; other site 272562000083 Rhodanese Homology Domain (RHOD); an alpha beta fold domain found duplicated in the rhodanese protein. The cysteine containing enzymatically active version of the domain is also found in the Cdc25 class of protein phosphatases and a variety of proteins...; Region: RHOD; cd00158 272562000084 active site residue [active] 272562000085 Putative redox-active protein (C_GCAxxG_C_C); Region: C_GCAxxG_C_C; pfam09719 272562000086 Rhodanese Homology Domain (RHOD); an alpha beta fold domain found duplicated in the rhodanese protein. The cysteine containing enzymatically active version of the domain is also found in the Cdc25 class of protein phosphatases and a variety of proteins...; Region: RHOD; cd00158 272562000087 active site residue [active] 272562000088 bifunctional acetaldehyde-CoA/alcohol dehydrogenase; Provisional; Region: PRK13805 272562000089 Coenzyme A acylating aldehyde dehydrogenase (ACDH), ALDH family 20-like; Region: ALDH_F20_ACDH; cd07122 272562000090 putative catalytic cysteine [active] 272562000091 C-terminal alcohol dehydrogenase domain of the acetaldehyde dehydrogenase-alcohol dehydrogenase bifunctional two-domain protein (AAD); Region: AAD_C; cd08178 272562000092 putative active site [active] 272562000093 metal binding site [ion binding]; metal-binding site 272562000094 Protein of unknown function (DUF342); Region: DUF342; cl19219 272562000095 Integral membrane protein CcmA involved in cell shape determination [Cell envelope biogenesis, outer membrane]; Region: CcmA; COG1664 272562000096 Protein of unknown function (DUF4004); Region: DUF4004; pfam13171 272562000097 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2350 272562000098 Protein of unknown function (DUF2892); Region: DUF2892; pfam11127 272562000099 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 272562000100 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 272562000101 non-specific DNA binding site [nucleotide binding]; other site 272562000102 salt bridge; other site 272562000103 sequence-specific DNA binding site [nucleotide binding]; other site 272562000104 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 272562000105 binding surface 272562000106 TPR motif; other site 272562000107 Tetratricopeptide repeat; Region: TPR_12; pfam13424 272562000108 Tetratricopeptide repeat; Region: TPR_12; pfam13424 272562000109 Predicted ferric reductase [Inorganic ion transport and metabolism]; Region: COG4097 272562000110 Ferric reductase like transmembrane component; Region: Ferric_reduct; pfam01794 272562000111 NAD(P) binding domain of ferredoxin reductase-like proteins catalyze electron transfer between an NAD(P)-binding sub-domain of the alpha/beta class and a discrete (usually N-terminal) domain, which varies in orientation with respect to the NAD(P)...; Region: FNR_like_3; cd06198 272562000112 FAD binding pocket [chemical binding]; other site 272562000113 FAD binding motif [chemical binding]; other site 272562000114 phosphate binding motif [ion binding]; other site 272562000115 beta-alpha-beta structure motif; other site 272562000116 NAD binding pocket [chemical binding]; other site 272562000117 This family includes the Gtfs, a group of homologous glycosyltransferases involved in the final stages of the biosynthesis of antibiotics vancomycin and related chloroeremomycin. Gtfs transfer sugar moieties from an activated NDP-sugar donor to the...; Region: GT1_Gtf_like; cd03784 272562000118 glycosyltransferase, MGT family; Region: MGT; TIGR01426 272562000119 active site 272562000120 TDP-binding site; other site 272562000121 acceptor substrate-binding pocket; other site 272562000122 homodimer interface [polypeptide binding]; other site 272562000123 probable dihydroxyacetone kinase regulator; Region: DHAK_reg; TIGR02366 272562000124 Bacterial regulatory proteins, tetR family; Region: TetR_N; cl19382 272562000125 Transcriptional regulator C-terminal region; Region: TetR_C_8; pfam14278 272562000126 Metal-dependent hydrolases of the beta-lactamase superfamily III [General function prediction only]; Region: ElaC; COG1234 272562000127 ribokinase/pfkB superfamily: Kinases that accept a wide variety of substrates, including carbohydrates and aromatic small molecules, all are phosphorylated at a hydroxyl group. The superfamily includes ribokinase, fructokinase, ketohexokinase; Region: ribokinase_pfkB_like; cl00192 272562000128 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cl19050 272562000129 dimer interface [polypeptide binding]; other site 272562000130 putative CheW interface [polypeptide binding]; other site 272562000131 enterobactin exporter EntS; Provisional; Region: PRK10489 272562000132 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 272562000133 putative substrate translocation pore; other site 272562000134 Carboxylesterase type B [Lipid metabolism]; Region: PnbA; COG2272 272562000135 substrate binding pocket [chemical binding]; other site 272562000136 catalytic triad [active] 272562000137 Short-chain dehydrogenases of various substrate specificities [General function prediction only]; Region: DltE; COG0300 272562000138 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 272562000139 NAD(P) binding site [chemical binding]; other site 272562000140 active site 272562000141 Transcriptional regulators [Transcription]; Region: MarR; COG1846 272562000142 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cl17220 272562000143 Beta-1,4-xylanase [Carbohydrate transport and metabolism]; Region: XynA; COG3693 272562000144 Predicted xylanase/chitin deacetylase [Carbohydrate transport and metabolism]; Region: CDA1; COG0726 272562000145 Putative catalytic NodB homology domain of PgaB, IcaB, and similar proteins which consist of a deformed (beta/alpha)8 barrel fold with 5- or 6-strands; Region: CE4_NodB_like_5s_6s; cd10918 272562000146 putative active site [active] 272562000147 putative metal binding site [ion binding]; other site 272562000148 CAAX protease self-immunity; Region: Abi; pfam02517 272562000149 parallel beta-helix repeat-containing protein; Region: beta_helix_1; TIGR03805 272562000150 Lipoproteins [Cell envelope biogenesis, outer membrane]; Region: RlpA; COG0797 272562000151 Rare lipoprotein A (RlpA)-like double-psi beta-barrel; Region: DPBB_1; pfam03330 272562000152 Iron-containing alcohol dehydrogenases-like; Region: Fe-ADH5; cd08189 272562000153 putative active site [active] 272562000154 metal binding site [ion binding]; metal-binding site 272562000155 Chloramphenicol O-acetyltransferase [Defense mechanisms]; Region: COG4845 272562000156 Mor transcription activator family; Region: Mor; cl02360 272562000157 manganese transport protein MntH; Reviewed; Region: PRK00701 272562000158 Natural resistance-associated macrophage protein; Region: Nramp; pfam01566 272562000159 Fructose-1.6-bisphosphate aldolase found in gram +/- bacteria; Region: FBP_aldolase_I_bact; cd00949 272562000160 putative active site [active] 272562000161 catalytic residue [active] 272562000162 M6 family metalloprotease domain; Region: M6dom_TIGR03296 272562000163 Coagulation factor 5/8 C-terminal domain, discoidin domain; Cell surface-attached carbohydrate-binding domain, present in eukaryotes and assumed to have horizontally transferred to eubacterial genomes; Region: FA58C; cl19067 272562000164 PTS system mannose-specific transporter subunits IIAB; Provisional; Region: PRK15088 272562000165 PTS_IIA, PTS system, mannose/sorbose specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIA_man; cd00006 272562000166 active pocket/dimerization site; other site 272562000167 active site 272562000168 phosphorylation site [posttranslational modification] 272562000169 PTS_IIB, PTS system, Mannose/sorbose specific IIB subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIB_man; cd00001 272562000170 active site 272562000171 phosphorylation site [posttranslational modification] 272562000172 PTS system mannose-specific transporter subunit IIC; Provisional; Region: PRK15065 272562000173 Phosphotransferase system, mannose/fructose/N-acetylgalactosamine-specific component IID [Carbohydrate transport and metabolism]; Region: ManZ; COG3716 272562000174 Domain of unknown function (DUF956); Region: DUF956; pfam06115 272562000175 Cof subfamily of IIB subfamily of haloacid dehalogenase superfamily; Region: Cof-subfamily; TIGR00099 272562000176 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 272562000177 active site 272562000178 motif I; other site 272562000179 motif II; other site 272562000180 haloacid dehalogenase-like hydrolase; Region: HAD; cl19137 272562000181 Enterochelin esterase and related enzymes [Inorganic ion transport and metabolism]; Region: Fes; COG2382 272562000182 Predicted hydrolase of the alpha/beta superfamily [General function prediction only]; Region: COG2819; cl19187 272562000183 Ricin-type beta-trefoil lectin domain; Region: Ricin_B_lectin; pfam00652 272562000184 Ricin-type beta-trefoil; Carbohydrate-binding domain formed from presumed gene triplication. The domain is found in a variety of molecules serving diverse functions such as enzymatic activity, inhibitory toxicity and signal transduction. Highly specific...; Region: RICIN; cd00161 272562000185 putative sugar binding sites [chemical binding]; other site 272562000186 Q-X-W motif; other site 272562000187 ABC-type bacteriocin/lantibiotic exporters, contain an N-terminal double-glycine peptidase domain [Defense mechanisms]; Region: SunT; COG2274 272562000188 A sub-family of peptidase family C39. Peptidase family C39 mostly contains bacteriocin-processing endopeptidases from bacteria. The cysteine peptidases in family C39 cleave the "double-glycine" leader peptides from the precursors of various...; Region: Peptidase_C39B; cd02418 272562000189 putative active site [active] 272562000190 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 272562000191 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 272562000192 Walker A/P-loop; other site 272562000193 ATP binding site [chemical binding]; other site 272562000194 Q-loop/lid; other site 272562000195 ABC transporter signature motif; other site 272562000196 Walker B; other site 272562000197 D-loop; other site 272562000198 H-loop/switch region; other site 272562000199 type I secretion membrane fusion protein, HlyD family; Region: type_I_hlyD; TIGR01843 272562000200 Predicted membrane protein [Function unknown]; Region: COG2323 272562000201 Membrane carboxypeptidase (penicillin-binding protein) [Cell envelope biogenesis, outer membrane]; Region: MrcB; COG0744 272562000202 Transglycosylase; Region: Transgly; pfam00912 272562000203 Uncharacterized Fe-S protein [Energy production and conversion]; Region: COG1600 272562000204 4Fe-4S double cluster binding domain; Region: Fer4_16; pfam13484 272562000205 putative acyltransferase; Provisional; Region: PRK05790 272562000206 Thiolase are ubiquitous enzymes that catalyze the reversible thiolytic cleavage of 3-ketoacyl-CoA into acyl-CoA and acetyl-CoA, a 2-step reaction involving a covalent intermediate formed with a catalytic cysteine. They are found in prokaryotes and...; Region: thiolase; cd00751 272562000207 dimer interface [polypeptide binding]; other site 272562000208 active site 272562000209 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 272562000210 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 272562000211 site-specific tyrosine recombinase XerC; Reviewed; Region: xerC; PRK00236 272562000212 DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213 272562000213 active site 272562000214 DNA binding site [nucleotide binding] 272562000215 Int/Topo IB signature motif; other site 272562000216 Site-specific recombinases, DNA invertase Pin homologs [DNA replication, recombination, and repair]; Region: PinR; COG1961 272562000217 Resolvase, N terminal domain; Region: Resolvase; pfam00239 272562000218 Helix-turn-helix domain of Hin and related proteins; Region: HTH_Hin_like; cl17393 272562000219 DNA-binding interface [nucleotide binding]; DNA binding site 272562000220 CRP/FNR family transcriptional regulator; Provisional; Region: PRK13918 272562000221 effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038 272562000222 ligand binding site [chemical binding]; other site 272562000223 flexible hinge region; other site 272562000224 helix_turn_helix, cAMP Regulatory protein C-terminus; DNA binding domain of prokaryotic regulatory proteins belonging to the catabolite activator protein family; Region: HTH_CRP; cd00092 272562000225 putative switch regulator; other site 272562000226 non-specific DNA interactions [nucleotide binding]; other site 272562000227 DNA binding site [nucleotide binding] 272562000228 sequence specific DNA binding site [nucleotide binding]; other site 272562000229 putative cAMP binding site [chemical binding]; other site 272562000230 Methyltransferase domain; Region: Methyltransf_31; pfam13847 272562000231 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 272562000232 S-adenosylmethionine binding site [chemical binding]; other site 272562000233 Protein of unknown function (DUF1648); Region: DUF1648; pfam07853 272562000234 Major Facilitator Superfamily; Region: MFS_1; pfam07690 272562000235 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 272562000236 putative substrate translocation pore; other site 272562000237 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 272562000238 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 272562000239 beta-ketoacyl-acyl-carrier-protein synthase II; Region: fabF; TIGR03150 272562000240 Beta-ketoacyl-acyl carrier protein (ACP) synthase (KAS), type I and II. KASs are responsible for the elongation steps in fatty acid biosynthesis. KASIII catalyses the initial condensation and KAS I and II catalyze further elongation steps by Claisen...; Region: KAS_I_II; cd00834 272562000241 dimer interface [polypeptide binding]; other site 272562000242 active site 272562000243 Acyltransferase family; Region: Acyl_transf_3; cl19154 272562000244 ABC-type multidrug transport system, ATPase component [Defense mechanisms]; Region: CcmA; COG1131 272562000245 ATP-binding cassette domain of the drug resistance transporter and related proteins, subfamily A; Region: ABC_DR_subfamily_A; cd03230 272562000246 Walker A/P-loop; other site 272562000247 ATP binding site [chemical binding]; other site 272562000248 Q-loop/lid; other site 272562000249 ABC transporter signature motif; other site 272562000250 Walker B; other site 272562000251 D-loop; other site 272562000252 H-loop/switch region; other site 272562000253 Regulators of stationary/sporulation gene expression [Transcription]; Region: AbrB; COG2002 272562000254 Tn3 transposase DDE domain; Region: DDE_Tnp_Tn3; pfam01526 272562000255 Transposase and inactivated derivatives, TnpA family [DNA replication, recombination, and repair]; Region: COG4644 272562000256 Inorganic pyrophosphatase [Energy production and conversion]; Region: Ppa; COG0221 272562000257 dimer interface [polypeptide binding]; other site 272562000258 Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596 272562000259 Putative lysophospholipase; Region: Hydrolase_4; cl19140 272562000260 TAP-like protein; Region: Abhydrolase_4; pfam08386 272562000261 Alpha amylase catalytic domain found in bacterial Alpha-amylases (also called 1,4-alpha-D-glucan-4-glucanohydrolase); Region: AmyAc_bac1_AmyA; cd11315 272562000262 Alpha amylase, catalytic domain; Region: Alpha-amylase; pfam00128 272562000263 active site 272562000264 Ca binding site [ion binding]; other site 272562000265 catalytic site [active] 272562000266 Aamy_C domain; Region: Aamy_C; smart00632 272562000267 Carbohydrate binding domain (family 25); Region: CBM_25; cl04060 272562000268 DNA-binding domain of DNA mismatch repair MUTS family; Region: MUTSd; smart00533 272562000269 MutS domain III; Region: MutS_III; pfam05192 272562000270 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 272562000271 Walker A/P-loop; other site 272562000272 ATP binding site [chemical binding]; other site 272562000273 Q-loop/lid; other site 272562000274 ABC transporter signature motif; other site 272562000275 Walker B; other site 272562000276 D-loop; other site 272562000277 H-loop/switch region; other site 272562000278 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 272562000279 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 272562000280 Transcriptional regulator C-terminal region; Region: TetR_C_8; pfam14278 272562000281 Protein involved in formate dehydrogenase formation; Region: FdhE; cl19312 272562000282 Predicted drug exporters of the RND superfamily [General function prediction only]; Region: COG2409 272562000283 MMPL family; Region: MMPL; cl14618 272562000284 MMPL family; Region: MMPL; cl14618 272562000285 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 272562000286 dimerization interface [polypeptide binding]; other site 272562000287 putative DNA binding site [nucleotide binding]; other site 272562000288 putative Zn2+ binding site [ion binding]; other site 272562000289 arsenical-resistance protein; Region: acr3; TIGR00832 272562000290 Low molecular weight phosphatase family; Region: LMWPc; cd00115 272562000291 active site 272562000292 1-deoxy-D-xylulose-5-phosphate synthase; Provisional; Region: PRK12315 272562000293 Thiamine pyrophosphate (TPP) family, DXS subfamily, TPP-binding module; 1-Deoxy-D-xylulose-5-phosphate synthase (DXS) is a regulatory enzyme of the mevalonate-independent pathway involved in terpenoid biosynthesis. Terpeniods are plant natural products...; Region: TPP_DXS; cd02007 272562000294 TPP-binding site; other site 272562000295 Pyrimidine (PYR) binding domain of 1-deoxy-D-xylulose-5-phosphate synthase (DXS), transketolase (TK), and related proteins; Region: TPP_PYR_DXS_TK_like; cd07033 272562000296 PYR/PP interface [polypeptide binding]; other site 272562000297 dimer interface [polypeptide binding]; other site 272562000298 TPP binding site [chemical binding]; other site 272562000299 Transketolase, C-terminal domain; Region: Transketolase_C; pfam02780 272562000300 Predicted transcriptional regulators [Transcription]; Region: SoxR; COG0789 272562000301 Helix-Turn-Helix DNA binding domain of the MerR-like transcription regulators YyaN and YraB; Region: HTH_YyaN; cd01109 272562000302 DNA binding residues [nucleotide binding] 272562000303 putative dimer interface [polypeptide binding]; other site 272562000304 Predicted transcriptional regulators [Transcription]; Region: COG1695 272562000305 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 272562000306 Major Facilitator Superfamily; Region: MFS_1; pfam07690 272562000307 putative substrate translocation pore; other site 272562000308 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 272562000309 Coenzyme A binding pocket [chemical binding]; other site 272562000310 Acetyltransferases [General function prediction only]; Region: RimI; COG0456 272562000311 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 272562000312 Coenzyme A binding pocket [chemical binding]; other site 272562000313 Solo B3/4 domain (OB-fold DNA/RNA-binding) of Phe-aaRS-beta [General function prediction only]; Region: COG3382 272562000314 Beta-xylosidase [Carbohydrate transport and metabolism]; Region: XynB; COG3507 272562000315 Glycosyl hydrolase family 43, beta-D-xylosidase; Region: GH43_XYL_2; cd09001 272562000316 active site 272562000317 Glycosyl hydrolase family 43, includes arabinoxylan arabinofuranohydrolase, beta-xylosidase, endo-1,4-beta-xylanase, alpha-L-arabinofuranosidase; Region: GH43_AXH_like; cd08990 272562000318 substrate binding site [chemical binding]; other site 272562000319 active site 272562000320 Carbohydrate Binding Module 6 (CBM6); many are appended to glycoside hydrolase (GH) family 11 and GH43 xylanase domains; Region: CBM6_xylanase-like; cd04084 272562000321 metal binding site [ion binding]; metal-binding site 272562000322 ligand binding site [chemical binding]; other site 272562000323 Beta-1,4-xylanase [Carbohydrate transport and metabolism]; Region: XynA; COG3693 272562000324 Glycosyl hydrolases family 39; Region: Glyco_hydro_39; pfam01229 272562000325 O-Glycosyl hydrolase [Cell envelope biogenesis, outer membrane]; Region: COG5520 272562000326 Ricin-type beta-trefoil; Carbohydrate-binding domain formed from presumed gene triplication. The domain is found in a variety of molecules serving diverse functions such as enzymatic activity, inhibitory toxicity and signal transduction. Highly specific...; Region: RICIN; cd00161 272562000327 Ricin-type beta-trefoil lectin domain; Region: Ricin_B_lectin; pfam00652 272562000328 putative sugar binding sites [chemical binding]; other site 272562000329 Q-X-W motif; other site 272562000330 O-Glycosyl hydrolase [Cell envelope biogenesis, outer membrane]; Region: COG5520 272562000331 Ricin-type beta-trefoil; Carbohydrate-binding domain formed from presumed gene triplication. The domain is found in a variety of molecules serving diverse functions such as enzymatic activity, inhibitory toxicity and signal transduction. Highly specific...; Region: RICIN; cd00161 272562000332 Ricin-type beta-trefoil lectin domain; Region: Ricin_B_lectin; pfam00652 272562000333 putative sugar binding sites [chemical binding]; other site 272562000334 Q-X-W motif; other site 272562000335 Glycosyl hydrolase family 43; Region: GH43_AXH_1; cd09003 272562000336 substrate binding site [chemical binding]; other site 272562000337 active site 272562000338 Carbohydrate Binding Module 6 (CBM6); many are appended to glycoside hydrolase (GH) family 11 and GH43 xylanase domains; Region: CBM6_xylanase-like; cd04084 272562000339 metal binding site [ion binding]; metal-binding site 272562000340 ligand binding site [chemical binding]; other site 272562000341 Ricin-type beta-trefoil lectin domain; Region: Ricin_B_lectin; pfam00652 272562000342 Ricin-type beta-trefoil; Carbohydrate-binding domain formed from presumed gene triplication. The domain is found in a variety of molecules serving diverse functions such as enzymatic activity, inhibitory toxicity and signal transduction. Highly specific...; Region: RICIN; cd00161 272562000343 putative sugar binding sites [chemical binding]; other site 272562000344 Q-X-W motif; other site 272562000345 Regulator of polyketide synthase expression [Signal transduction mechanisms / Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG2508 272562000346 PucR C-terminal helix-turn-helix domain; Region: HTH_30; pfam13556 272562000347 dTDP-4-dehydrorhamnose reductase [Cell envelope biogenesis, outer membrane]; Region: RfbD; COG1091 272562000348 dTDP-6-deoxy-L-lyxo-4-hexulose reductase and related proteins, extended (e) SDRs; Region: dTDP_HR_like_SDR_e; cd05254 272562000349 NADP binding site [chemical binding]; other site 272562000350 active site 272562000351 putative substrate binding site [chemical binding]; other site 272562000352 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 272562000353 Major Facilitator Superfamily; Region: MFS_1; pfam07690 272562000354 putative substrate translocation pore; other site 272562000355 [FeFe] hydrogenase H-cluster maturation GTPase HydF; Region: GTP_HydF; TIGR03918 272562000356 Plasmid segregation protein ParM and similar proteins; Region: ParM_like; cd10227 272562000357 Mg binding site [ion binding]; other site 272562000358 nucleotide binding site [chemical binding]; other site 272562000359 putative protofilament interface [polypeptide binding]; other site 272562000360 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 272562000361 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 272562000362 drug resistance transporter, EmrB/QacA subfamily; Region: efflux_EmrB; TIGR00711 272562000363 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 272562000364 putative substrate translocation pore; other site 272562000365 Putative phosphatase regulatory subunit; Region: CBM_21; pfam03370 272562000366 Putative phosphatase regulatory subunit; Region: CBM_21; pfam03370 272562000367 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 272562000368 Major Facilitator Superfamily; Region: MFS_1; pfam07690 272562000369 putative substrate translocation pore; other site 272562000370 Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596 272562000371 Putative lysophospholipase; Region: Hydrolase_4; cl19140 272562000372 Putative lysophospholipase; Region: Hydrolase_4; cl19140 272562000373 3-oxoacyl-[acyl-carrier-protein]; Region: FabH; COG0332 272562000374 Condensing enzymes; Family of enzymes that catalyze a (decarboxylating or non-decarboxylating) Claisen-like condensation reaction. Members are share strong structural similarity, and are involved in the synthesis and degradation of fatty acids, and the...; Region: cond_enzymes; cl09938 272562000375 active site 272562000376 Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673 272562000377 Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408 272562000378 Oxidoreductase family, C-terminal alpha/beta domain; Region: GFO_IDH_MocA_C; pfam02894 272562000379 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 272562000380 Radical SAM superfamily; Region: Radical_SAM; pfam04055 272562000381 FeS/SAM binding site; other site 272562000382 Iron-sulfur cluster-binding domain; Region: SPASM; pfam13186 272562000383 Glycosyltransferase family 28 C-terminal domain; Region: Glyco_tran_28_C; cl19139 272562000384 ATP-grasp domain; Region: ATP-grasp_4; cl17255 272562000385 Phosphopantetheine attachment site; Region: PP-binding; pfam00550 272562000386 Na+/H+ antiporter [Energy production and conversion]; Region: NhaC; COG1757 272562000387 Na+/H+ antiporter family; Region: Na_H_antiporter; pfam03553 272562000388 Ni,Fe-hydrogenase I small subunit [Energy production and conversion]; Region: HyaA; COG1740 272562000389 NADH ubiquinone oxidoreductase, 20 Kd subunit; Region: Oxidored_q6; pfam01058 272562000390 NiFe/NiFeSe hydrogenase small subunit C-terminal; Region: NiFe_hyd_SSU_C; pfam14720 272562000391 Ni,Fe-hydrogenase I large subunit [Energy production and conversion]; Region: HyaB; COG0374 272562000392 coenzyme F420-reducing hydrogenase delta subunit (putative coenzyme F420 hydrogenase processing subunit); Region: frhD; TIGR00130 272562000393 Hydrogenase specific C-terminal endopeptidases, also called Hydrogen Maturation Proteases (H2MP). These enzymes belong to the peptidase family M52. Maturation of [FeNi] hydrogenases includes formation of the nickel metallocenter, proteolytic processing...; Region: H2MP; cd00518 272562000394 nickel binding site [ion binding]; other site 272562000395 Predicted heme/steroid binding protein [General function prediction only]; Region: COG4892 272562000396 Hydrogenase maturation factor [Posttranslational modification, protein turnover, chaperones]; Region: HypF; COG0068 272562000397 HypF finger; Region: zf-HYPF; pfam07503 272562000398 Telomere recombination; Region: Sua5_yciO_yrdC; pfam01300 272562000399 Predicted membrane protein [Function unknown]; Region: COG2323 272562000400 Zinc dependent phospholipase C (alpha toxin); Region: Zn_dep_PLPC; cd11009 272562000401 Zn binding site [ion binding]; other site 272562000402 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 272562000403 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 272562000404 non-specific DNA binding site [nucleotide binding]; other site 272562000405 salt bridge; other site 272562000406 sequence-specific DNA binding site [nucleotide binding]; other site 272562000407 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 272562000408 binding surface 272562000409 TPR motif; other site 272562000410 Cell division protein FtsI/penicillin-binding protein 2 [Cell envelope biogenesis, outer membrane]; Region: FtsI; COG0768 272562000411 Penicillin-binding Protein dimerization domain; Region: PBP_dimer; pfam03717 272562000412 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; pfam00905 272562000413 Repeat domain in Vibrio, Colwellia, Bradyrhizobium and Shewanella; Region: VCBS; pfam13517 272562000414 Repeat domain in Vibrio, Colwellia, Bradyrhizobium and Shewanella; Region: VCBS; pfam13517 272562000415 Repeat domain in Vibrio, Colwellia, Bradyrhizobium and Shewanella; Region: VCBS; pfam13517 272562000416 Repeat domain in Vibrio, Colwellia, Bradyrhizobium and Shewanella; Region: VCBS; pfam13517 272562000417 Repeat domain in Vibrio, Colwellia, Bradyrhizobium and Shewanella; Region: VCBS; pfam13517 272562000418 Endolysins and autolysins are found in viruses and bacteria, respectively. The ds DNA phages of eubacteria use endolysins or muralytic enzymes in conjunction with hollin, a small membrane protein, to degrade the peptidoglycan found in bacterial cell...; Region: endolysin_autolysin; cd00737 272562000419 catalytic residues [active] 272562000420 Predicted transcriptional regulators [Transcription]; Region: COG1695 272562000421 Protein of unknown function (DUF1048); Region: DUF1048; cl01986 272562000422 RNA polymerase sigma factor, sigma-70 family; Region: sigma70-ECF; TIGR02937 272562000423 fibritin; Provisional; Region: wac; PHA02607 272562000424 Bacterial surface proteins containing Ig-like domains [Cell motility and secretion]; Region: COG5492 272562000425 Bacterial Ig-like domain (group 2); Region: Big_2; pfam02368 272562000426 Bacterial surface proteins containing Ig-like domains [Cell motility and secretion]; Region: COG5492 272562000427 Bacterial Ig-like domain (group 2); Region: Big_2; pfam02368 272562000428 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 272562000429 binding surface 272562000430 TPR motif; other site 272562000431 TPR repeat; Region: TPR_11; pfam13414 272562000432 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 272562000433 binding surface 272562000434 TPR motif; other site 272562000435 Tetratricopeptide repeat; Region: TPR_12; pfam13424 272562000436 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 272562000437 binding surface 272562000438 TPR repeat; Region: TPR_11; pfam13414 272562000439 TPR motif; other site 272562000440 bifunctional acetaldehyde-CoA/alcohol dehydrogenase; Provisional; Region: PRK13805 272562000441 Coenzyme A acylating aldehyde dehydrogenase (ACDH), Ethanolamine utilization protein EutE, and related proteins; Region: ALDH_F20_ACDH_EutE-like; cd07081 272562000442 putative catalytic cysteine [active] 272562000443 C-terminal alcohol dehydrogenase domain of the acetaldehyde dehydrogenase-alcohol dehydrogenase bifunctional two-domain protein (AAD); Region: AAD_C; cd08178 272562000444 putative active site [active] 272562000445 metal binding site [ion binding]; metal-binding site 272562000446 Acyl CoA:acetate/3-ketoacid CoA transferase, alpha subunit [Lipid metabolism]; Region: AtoD; COG1788 272562000447 Coenzyme A transferase; Region: CoA_trans; cl17247 272562000448 acetoacetate decarboxylase; Provisional; Region: PRK02265 272562000449 YvrJ protein family; Region: YvrJ; pfam12841 272562000450 RNA polymerase sigma factor, sigma-70 family; Region: sigma70-ECF; TIGR02937 272562000451 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 272562000452 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cl17257 272562000453 DNA binding residues [nucleotide binding] 272562000454 Glycosidases [Carbohydrate transport and metabolism]; Region: AmyA; COG0366 272562000455 Alpha amylase catalytic domain found in bacterial Alpha-amylases (also called 1,4-alpha-D-glucan-4-glucanohydrolase); Region: AmyAc_bac1_AmyA; cd11315 272562000456 active site 272562000457 Ca binding site [ion binding]; other site 272562000458 catalytic site [active] 272562000459 Aamy_C domain; Region: Aamy_C; smart00632 272562000460 Carbohydrate binding domain (family 25); Region: CBM_25; cl04060 272562000461 Early set domain associated with the catalytic domain of sugar utilizing enzymes at either the N or C terminus; Region: E_set; cd02688 272562000462 Carbohydrate binding domain (family 25); Region: CBM_25; cl04060 272562000463 Protein of unknown function (DUF2922); Region: DUF2922; pfam11148 272562000464 Protein of unknown function (DUF2922); Region: DUF2922; pfam11148 272562000465 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 272562000466 FeS/SAM binding site; other site 272562000467 Radical SAM superfamily; Region: Radical_SAM; pfam04055 272562000468 Uncharacterized conserved protein [Function unknown]; Region: COG2898 272562000469 Protein involved in initiation of plasmid replication [DNA replication, recombination, and repair]; Region: COG5527 272562000470 Initiator Replication protein; Region: Rep_3; pfam01051 272562000471 Ribbon-helix-helix protein, copG family; Region: RHH_1; pfam01402 272562000472 ATPases involved in chromosome partitioning [Cell division and chromosome partitioning]; Region: Soj; COG1192 272562000473 ParA and ParB of Caulobacter crescentus belong to a conserved family of bacterial proteins implicated in chromosome segregation. ParB binds to DNA sequences adjacent to the origin of replication and localizes to opposite cell poles shortly following the...; Region: ParA; cd02042 272562000474 The Fer4_NifH superfamily contains a variety of proteins which share a common ATP-binding domain. Functionally, proteins in this superfamily use the energy from hydrolysis of NTP to transfer electron or ion; Region: Fer4_NifH; cl17203 272562000475 P-loop; other site 272562000476 Magnesium ion binding site [ion binding]; other site 272562000477 Predicted transcriptional regulators [Transcription]; Region: SoxR; COG0789 272562000478 Helix-Turn-Helix DNA binding domain of the MerR-like transcription regulators YyaN and YraB; Region: HTH_YyaN; cd01109 272562000479 DNA binding residues [nucleotide binding] 272562000480 putative dimer interface [polypeptide binding]; other site 272562000481 chromosomal replication initiation protein; Reviewed; Region: dnaA; PRK00149 272562000482 DnaA N-terminal domain; Region: DnaA_N; pfam11638 272562000483 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 272562000484 Walker A motif; other site 272562000485 ATP binding site [chemical binding]; other site 272562000486 Walker B motif; other site 272562000487 arginine finger; other site 272562000488 C-terminal domain of bacterial DnaA proteins. The DNA-binding C-terminal domain of DnaA contains a helix-turn-helix motif that specifically interacts with the DnaA box, a 9-mer motif that occurs repetitively in the replication origin oriC. Multiple...; Region: Bac_DnaA_C; cd06571 272562000489 DnaA box-binding interface [nucleotide binding]; other site 272562000490 DNA polymerase III subunit beta; Validated; Region: PRK05643 272562000491 Beta clamp domain. The beta subunit (processivity factor) of DNA polymerase III holoenzyme, refered to as the beta clamp, forms a ring shaped dimer that encircles dsDNA (sliding clamp) in bacteria. The beta-clamp is structurally similar to the trimeric...; Region: beta_clamp; cd00140 272562000492 putative DNA binding surface [nucleotide binding]; other site 272562000493 dimer interface [polypeptide binding]; other site 272562000494 beta-clamp/clamp loader binding surface; other site 272562000495 beta-clamp/translesion DNA polymerase binding surface; other site 272562000496 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 272562000497 RNA binding surface [nucleotide binding]; other site 272562000498 Recombinational DNA repair ATPase (RecF pathway) [DNA replication, recombination, and repair]; Region: RecF; COG1195 272562000499 ATP-binding cassette domain of RecF; Region: ABC_RecF; cd03242 272562000500 Walker A/P-loop; other site 272562000501 ATP binding site [chemical binding]; other site 272562000502 Q-loop/lid; other site 272562000503 ABC transporter signature motif; other site 272562000504 Walker B; other site 272562000505 D-loop; other site 272562000506 H-loop/switch region; other site 272562000507 Glycosyl transferases group 1; Region: Glycos_transf_1; cl19138 272562000508 DNA gyrase subunit B; Validated; Region: gyrB; PRK05644 272562000509 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 272562000510 ATP binding site [chemical binding]; other site 272562000511 Mg2+ binding site [ion binding]; other site 272562000512 G-X-G motif; other site 272562000513 TopoIIA_Trans_DNA_gyrase: Transducer domain, having a ribosomal S5 domain 2-like fold, of the type found in proteins of the type IIA family of DNA topoisomerases similar to the B subunits of E. coli DNA gyrase and E. coli Topoisomerase IV which are; Region: TopoII_Trans_DNA_gyrase; cd00822 272562000514 anchoring element; other site 272562000515 dimer interface [polypeptide binding]; other site 272562000516 ATP binding site [chemical binding]; other site 272562000517 TOPRIM_TopoIIA_GyrB: topoisomerase-primase (TOPRIM) nucleotidyl transferase/hydrolase domain of the type found in proteins of the type IIA family of DNA topoisomerases similar to the Escherichia coli GyrB subunit. TopoIIA enzymes cut both strands of the...; Region: TOPRIM_TopoIIA_GyrB; cd03366 272562000518 active site 272562000519 putative metal-binding site [ion binding]; other site 272562000520 DNA gyrase B subunit, carboxyl terminus; Region: DNA_gyraseB_C; pfam00986 272562000521 DNA gyrase subunit A; Validated; Region: PRK05560 272562000522 DNA Topoisomerase, subtype IIA; domain A'; bacterial DNA topoisomerase IV (C subunit, ParC), bacterial DNA gyrases (A subunit, GyrA),mammalian DNA toposiomerases II. DNA topoisomerases are essential enzymes that regulate the conformational changes...; Region: TOP4c; cd00187 272562000523 CAP-like domain; other site 272562000524 active site 272562000525 primary dimer interface [polypeptide binding]; other site 272562000526 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 272562000527 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 272562000528 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 272562000529 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 272562000530 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 272562000531 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 272562000532 HD domain; Region: HD; pfam01966 272562000533 Predicted small molecule binding protein (contains 3H domain) [General function prediction only]; Region: COG1827 272562000534 HTH domain; Region: HTH_11; pfam08279 272562000535 3H domain; Region: 3H; pfam02829 272562000536 hypothetical protein; Validated; Region: PRK00068 272562000537 Uncharacterized protein conserved in bacteria [Function unknown]; Region: ErfK; COG1376 272562000538 L,D-transpeptidase catalytic domain; Region: YkuD; pfam03734 272562000539 Predicted dehydrogenase [General function prediction only]; Region: COG0579 272562000540 hydroxyglutarate oxidase; Provisional; Region: PRK11728; cl19156 272562000541 BFD-like [2Fe-2S] binding domain; Region: Fer2_BFD; pfam04324 272562000542 Uncharacterized protein with conserved CXXC pairs [Function unknown]; Region: COG3862 272562000543 Serine-pyruvate aminotransferase/archaeal aspartate aminotransferase [Amino acid transport and metabolism]; Region: COG0075 272562000544 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 272562000545 catalytic residue [active] 272562000546 Phosphoglycerate dehydrogenase and related dehydrogenases [Amino acid transport and metabolism]; Region: SerA; COG0111 272562000547 Phosphoglycerate dehydrogenase (PGDH) NAD-binding and catalytic domains; Region: PGDH_2; cd05303 272562000548 putative ligand binding site [chemical binding]; other site 272562000549 NAD binding site [chemical binding]; other site 272562000550 dimerization interface [polypeptide binding]; other site 272562000551 catalytic site [active] 272562000552 Uncharacterized conserved protein [Function unknown]; Region: COG4198 272562000553 seryl-tRNA synthetase; Provisional; Region: PRK05431 272562000554 Seryl-tRNA synthetase N-terminal domain; Region: Seryl_tRNA_N; pfam02403 272562000555 Seryl-tRNA synthetase (SerRS) class II core catalytic domain. SerRS is responsible for the attachment of serine to the 3' OH group of ribose of the appropriate tRNA. This domain It is primarily responsible for ATP-dependent formation of the enzyme...; Region: SerRS_core; cd00770 272562000556 dimer interface [polypeptide binding]; other site 272562000557 active site 272562000558 motif 1; other site 272562000559 motif 2; other site 272562000560 motif 3; other site 272562000561 Putative NADPH-quinone reductase (modulator of drug activity B) [General function prediction only]; Region: MdaB; COG2249 272562000562 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 272562000563 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 272562000564 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 272562000565 Major Facilitator Superfamily; Region: MFS_1; pfam07690 272562000566 putative substrate translocation pore; other site 272562000567 Predicted membrane protein [Function unknown]; Region: COG1511 272562000568 seryl-tRNA synthetase; Provisional; Region: PRK05431 272562000569 Seryl-tRNA synthetase N-terminal domain; Region: Seryl_tRNA_N; pfam02403 272562000570 Seryl-tRNA synthetase (SerRS) class II core catalytic domain. SerRS is responsible for the attachment of serine to the 3' OH group of ribose of the appropriate tRNA. This domain It is primarily responsible for ATP-dependent formation of the enzyme...; Region: SerRS_core; cd00770 272562000571 dimer interface [polypeptide binding]; other site 272562000572 active site 272562000573 motif 1; other site 272562000574 motif 2; other site 272562000575 motif 3; other site 272562000576 aspartate-semialdehyde dehydrogenase; Reviewed; Region: PRK08664 272562000577 Semialdehyde dehydrogenase, NAD binding domain; Region: Semialdhyde_dh; pfam01118 272562000578 Semialdehyde dehydrogenase, dimerization domain; Region: Semialdhyde_dhC; pfam02774 272562000579 Transcriptional regulator [Transcription]; Region: LysR; COG0583 272562000580 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 272562000581 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cd05466 272562000582 dimerization interface [polypeptide binding]; other site 272562000583 Predicted membrane protein [Function unknown]; Region: COG4713 272562000584 Trimeric dUTP diphosphatases; Region: trimeric_dUTPase; cd07557 272562000585 trimer interface [polypeptide binding]; other site 272562000586 active site 272562000587 Alpha/beta hydrolase family; Region: Abhydrolase_5; pfam12695 272562000588 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 272562000589 active site 272562000590 bidirectional hydrogenase complex protein HoxU; Validated; Region: PRK07569 272562000591 2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207 272562000592 catalytic loop [active] 272562000593 iron binding site [ion binding]; other site 272562000594 NADH-ubiquinone oxidoreductase-G iron-sulfur binding region; Region: NADH-G_4Fe-4S_3; smart00929 272562000595 [FeFe] hydrogenase, group A; Region: FeFe_hydrog_A; TIGR02512 272562000596 4Fe-4S dicluster domain; Region: Fer4_8; pfam13183 272562000597 Iron only hydrogenase large subunit, C-terminal domain; Region: Fe_hyd_lg_C; pfam02906 272562000598 Iron hydrogenase small subunit; Region: Fe_hyd_SSU; pfam02256 272562000599 Uncharacterized distant relative of cell wall-associated hydrolases [Function unknown]; Region: COG3863 272562000600 phosphatidylserine decarboxylase; Provisional; Region: PRK00723 272562000601 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 272562000602 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 272562000603 YsiA-like protein, C-terminal region; Region: TetR_C_4; pfam08359 272562000604 2-polyprenylphenol 6-hydroxylase; Region: UbiB; TIGR01982 272562000605 Predicted unusual protein kinase [General function prediction only]; Region: AarF; COG0661 272562000606 active site 272562000607 ATP binding site [chemical binding]; other site 272562000608 Uncharacterized conserved protein [Function unknown]; Region: COG3937 272562000609 Serine/threonine phosphatases, family 2C, catalytic domain; The protein architecture and deduced catalytic mechanism of PP2C phosphatases are similar to the PP1, PP2A, PP2B family of protein Ser/Thr phosphatases, with which PP2C shares no sequence...; Region: PP2Cc; cd00143 272562000610 active site 272562000611 FOG: FHA domain [Signal transduction mechanisms]; Region: COG1716 272562000612 Forkhead associated domain (FHA); found in eukaryotic and prokaryotic proteins. Putative nuclear signalling domain. FHA domains may bind phosphothreonine, phosphoserine and sometimes phosphotyrosine. In eukaryotes, many FHA domain-containing proteins...; Region: FHA; cd00060 272562000613 phosphopeptide binding site; other site 272562000614 AAA domain; Region: AAA_31; pfam13614 272562000615 CobQ/CobB/MinD/ParA nucleotide binding domain; Region: CbiA; pfam01656 272562000616 WXG100 protein secretion system (Wss), protein YukD; Region: YukD; pfam08817 272562000617 FOG: FHA domain [Signal transduction mechanisms]; Region: COG1716 272562000618 Forkhead associated domain (FHA); found in eukaryotic and prokaryotic proteins. Putative nuclear signalling domain. FHA domains may bind phosphothreonine, phosphoserine and sometimes phosphotyrosine. In eukaryotes, many FHA domain-containing proteins...; Region: FHA; cd00060 272562000619 phosphopeptide binding site; other site 272562000620 type VII secretion protein EssC, C-terminal domain; Region: T7_EssCb_Firm; TIGR03928 272562000621 FtsK/SpoIIIE family; Region: FtsK_SpoIIIE; pfam01580 272562000622 FtsK/SpoIIIE family; Region: FtsK_SpoIIIE; pfam01580 272562000623 FtsK/SpoIIIE family; Region: FtsK_SpoIIIE; pfam01580 272562000624 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4842 272562000625 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4842 272562000626 CAAD domains of cyanobacterial aminoacyl-tRNA synthetase; Region: CAAD; cl19721 272562000627 TPR repeat; Region: TPR_11; pfam13414 272562000628 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 272562000629 binding surface 272562000630 TPR motif; other site 272562000631 FOG: TPR repeat [General function prediction only]; Region: NrfG; COG0457 272562000632 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 272562000633 binding surface 272562000634 TPR motif; other site 272562000635 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 272562000636 binding surface 272562000637 TPR motif; other site 272562000638 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 272562000639 TPR motif; other site 272562000640 TPR repeat; Region: TPR_11; pfam13414 272562000641 binding surface 272562000642 WXG100 family type VII secretion target; Region: WXG100_ESAT6; TIGR03930 272562000643 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4332 272562000644 cyanobacterial long protein repeat; Region: swm_rep_I; TIGR02059 272562000645 Nck-associated protein 5, Peripheral clock protein; Region: NCKAP5; pfam15246 272562000646 Prophage tail length tape measure protein; Region: TMP_2; pfam06791 272562000647 Phage-related protein [Function unknown]; Region: COG4722 272562000648 Phage-related protein [Function unknown]; Region: PblB; COG4926 272562000649 Prophage endopeptidase tail; Region: Prophage_tail; cl19379 272562000650 ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136 272562000651 ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255 272562000652 Walker A/P-loop; other site 272562000653 ATP binding site [chemical binding]; other site 272562000654 Q-loop/lid; other site 272562000655 ABC transporter signature motif; other site 272562000656 Walker B; other site 272562000657 D-loop; other site 272562000658 H-loop/switch region; other site 272562000659 FtsX-like permease family; Region: FtsX; pfam02687 272562000660 ABC-type antimicrobial peptide transport system, permease component [Defense mechanisms]; Region: SalY; COG0577 272562000661 Hemerythrin; Region: Hemerythrin; cd12107 272562000662 Fe binding site [ion binding]; other site 272562000663 Domain of unknown function (DUF4163); Region: DUF4163; pfam13739 272562000664 Regulator of cell morphogenesis and NO signaling [Cell division and chromosome partitioning]; Region: COG2846 272562000665 Domain of Unknown function (DUF542); Region: ScdA_N; pfam04405 272562000666 Hemerythrin HHE cation binding domain; Region: Hemerythrin; pfam01814 272562000667 Fe binding site [ion binding]; other site 272562000668 Uncharacterized conserved protein [Function unknown]; Region: COG4309 272562000669 Pentapeptide repeats containing protein [Function unknown]; Region: COG1357 272562000670 Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805 272562000671 Cysteine-rich 4 helical bundle widely conserved in bacteria; Region: DUF326; cd08026 272562000672 dimerization interface [polypeptide binding]; other site 272562000673 Permeases of the drug/metabolite transporter (DMT) superfamily [Carbohydrate transport and metabolism / Amino acid transport and metabolism / General function prediction only]; Region: RhaT; COG0697 272562000674 EamA-like transporter family; Region: EamA; pfam00892 272562000675 EamA-like transporter family; Region: EamA; pfam00892 272562000676 CAAX protease self-immunity; Region: Abi; pfam02517 272562000677 putative accessory gene regulator protein; Provisional; Region: PRK01100 272562000678 cyclic lactone autoinducer peptide; Region: quorum_AgrD; TIGR04223 272562000679 Predicted signal transduction protein with a C-terminal ATPase domain [Signal transduction mechanisms]; Region: COG2972 272562000680 GHKL domain; Region: HATPase_c_5; pfam14501 272562000681 Response regulator of the LytR/AlgR family [Transcription / Signal transduction mechanisms]; Region: LytT; COG3279 272562000682 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 272562000683 active site 272562000684 phosphorylation site [posttranslational modification] 272562000685 intermolecular recognition site; other site 272562000686 dimerization interface [polypeptide binding]; other site 272562000687 LytTr DNA-binding domain; Region: LytTR; pfam04397 272562000688 Lantibiotic modifying enzyme [Defense mechanisms]; Region: LcnDR2; COG4403 272562000689 LanC-like proteins. LanC is the cyclase enzyme of the lanthionine synthetase. Lanthionine is a lantibiotic, a unique class of peptide antibiotics. They are ribosomally synthesized as a precursor peptide and then post-translationally modified to contain...; Region: LanC_like; cl04955 272562000690 active site 272562000691 zinc binding site [ion binding]; other site 272562000692 Ribosomal L29 protein/HIP. L29 is a protein of the large ribosomal Subunit. A homolog, called heparin/heparan sulfate interacting protein (HIP), has also been identified in mammals. L29 is located on the surface of the large ribosomal subunit, where it...; Region: Ribosomal_L29_HIP; cl09943 272562000693 Growth inhibitor [Signal transduction mechanisms]; Region: MazF; COG2337 272562000694 MutT homolog-1 (MTH1) is a member of the Nudix hydrolase superfamily. MTH1, the mammalian counterpart of MutT, hydrolyzes oxidized purine nucleoside triphosphates, such as 8-oxo-dGTP and 2-hydroxy-ATP, to monophosphates, thereby preventing the...; Region: MTH1; cd03427 272562000695 putative active site [active] 272562000696 nucleotide binding site [chemical binding]; other site 272562000697 nudix motif; other site 272562000698 putative metal binding site [ion binding]; other site 272562000699 3-carboxymuconate cyclase [Carbohydrate transport and metabolism]; Region: COG2706 272562000700 Predicted Co/Zn/Cd cation transporters [Inorganic ion transport and metabolism]; Region: MMT1; COG0053 272562000701 methionine sulfoxide reductase A; Provisional; Region: PRK14054 272562000702 Phosphoglycerate dehydrogenase and related dehydrogenases [Amino acid transport and metabolism]; Region: SerA; COG0111 272562000703 Putative glycerate dehydrogenase and related proteins of the D-specific 2-hydroxy dehydrogenase family; Region: GDH_like_1; cd12161 272562000704 putative ligand binding site [chemical binding]; other site 272562000705 putative NAD binding site [chemical binding]; other site 272562000706 catalytic site [active] 272562000707 SurA N-terminal domain; Region: SurA_N_3; cl07813 272562000708 Predicted xylanase/chitin deacetylase [Carbohydrate transport and metabolism]; Region: CDA1; COG0726 272562000709 Catalytic NodB homology domain of Streptococcus mutans polysaccharide deacetylase PgdA, Bacillus subtilis YheN, and similar proteins; Region: CE4_SmPgdA_like; cd10944 272562000710 NodB motif; other site 272562000711 active site 272562000712 catalytic site [active] 272562000713 Zn binding site [ion binding]; other site 272562000714 ketol-acid reductoisomerase; Provisional; Region: PRK05479 272562000715 Acetohydroxy acid isomeroreductase, catalytic domain; Region: IlvN; pfam07991 272562000716 Acetohydroxy acid isomeroreductase, catalytic domain; Region: IlvC; pfam01450 272562000717 Predicted membrane protein [Function unknown]; Region: COG2707 272562000718 Transcriptional regulator [Transcription]; Region: LysR; COG0583 272562000719 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 272562000720 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 272562000721 dimerization interface [polypeptide binding]; other site 272562000722 Sulfite reductase, beta subunit (hemoprotein) [Inorganic ion transport and metabolism]; Region: CysI; COG0155 272562000723 Nitrite/Sulfite reductase ferredoxin-like half domain; Region: NIR_SIR_ferr; pfam03460 272562000724 Nitrite and sulphite reductase 4Fe-4S domain; Region: NIR_SIR; pfam01077 272562000725 Nitrite/Sulfite reductase ferredoxin-like half domain; Region: NIR_SIR_ferr; pfam03460 272562000726 The HCP family of iron-sulfur proteins includes hybrid cluster protein (HCP), acetyl-CoA synthase (ACS), and carbon monoxide dehydrogenase (CODH), all of which contain [Fe4-S4] metal clusters at their active sites. These proteins have a conserved...; Region: HCP_like; cl19102 272562000727 Glutamyl-tRNA reductase [Coenzyme metabolism]; Region: HemA; COG0373 272562000728 NAD(P) binding domain of amino acid dehydrogenase-like proteins; Region: NAD_bind_amino_acid_DH; cl17226 272562000729 NAD(P) binding pocket [chemical binding]; other site 272562000730 Glutamyl-tRNAGlu reductase, dimerization domain; Region: GlutR_dimer; pfam00745 272562000731 precorrin-2 dehydrogenase; Provisional; Region: PRK05562 272562000732 Putative NAD(P)-binding; Region: NAD_binding_7; pfam13241 272562000733 porphobilinogen deaminase; Reviewed; Region: hemC; PRK00072 272562000734 Hydroxymethylbilane synthase (HMBS), also known as porphobilinogen deaminase (PBGD), is an intermediate enzyme in the biosynthetic pathway of tetrapyrrolic ring systems, such as heme, chlorophylls, and vitamin B12. HMBS catalyzes the conversion of...; Region: HMBS; cd00494 272562000735 domain interfaces; other site 272562000736 active site 272562000737 Uroporphyrin-III C-methyltransferase (S-Adenosyl-L-methionine:uroporphyrinogen III methyltransferase, SUMT); Region: SUMT; cd11642 272562000738 active site 272562000739 SAM binding site [chemical binding]; other site 272562000740 homodimer interface [polypeptide binding]; other site 272562000741 Uroporphyrinogen-III synthase (HemD) catalyzes the asymmetrical cyclization of tetrapyrrole (linear) to uroporphyrinogen-III, the fourth step in the biosynthesis of heme. This ubiquitous enzyme is present in eukaryotes, bacteria and archaea. Mutations in...; Region: HemD; cd06578 272562000742 active site 272562000743 glutamate-1-semialdehyde aminotransferase; Provisional; Region: PRK00062 272562000744 Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610 272562000745 inhibitor-cofactor binding pocket; inhibition site 272562000746 pyridoxal 5'-phosphate binding site [chemical binding]; other site 272562000747 catalytic residue [active] 272562000748 Porphobilinogen synthase (PBGS), which is also called delta-aminolevulinic acid dehydratase (ALAD), catalyzes the condensation of two 5-aminolevulinic acid (ALA) molecules to form the pyrrole porphobilinogen (PBG), which is the second step in the...; Region: ALAD_PBGS; cd00384 272562000749 dimer interface [polypeptide binding]; other site 272562000750 active site 272562000751 Schiff base residues; other site 272562000752 CGS_like: Cystathionine gamma-synthase is a PLP dependent enzyme and catalyzes the committed step of methionine biosynthesis. This pathway is unique to microorganisms and plants, rendering the enzyme an attractive target for the development of...; Region: CGS_like; cd00614 272562000753 homodimer interface [polypeptide binding]; other site 272562000754 substrate-cofactor binding pocket; other site 272562000755 pyridoxal 5'-phosphate binding site [chemical binding]; other site 272562000756 catalytic residue [active] 272562000757 Adenosine 5'-phosphosulfate kinase (APSK) catalyzes the phosphorylation of adenosine 5'-phosphosulfate to form 3'-phosphoadenosine 5'-phosphosulfate (PAPS). The end-product PAPS is a biologically "activated" sulfate form...; Region: APSK; cd02027 272562000758 Thymidylate kinase [Nucleotide transport and metabolism]; Region: Tmk; COG0125 272562000759 ligand-binding site [chemical binding]; other site 272562000760 adenylylsulfate reductase subunit alpha; Validated; Region: PRK06854 272562000761 L-aspartate oxidase; Provisional; Region: PRK06175 272562000762 Fumarate reductase flavoprotein C-term; Region: Succ_DH_flav_C; pfam02910 272562000763 Ferredoxin [Energy production and conversion]; Region: COG1146 272562000764 RPB11 and RPB3 subunits of RNA polymerase; Region: RNAP_RPB11_RPB3; cl11409 272562000765 ABC transporter, substrate-binding protein, aliphatic sulfonates family; Region: SsuA_fam; TIGR01728 272562000766 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 272562000767 substrate binding pocket [chemical binding]; other site 272562000768 membrane-bound complex binding site; other site 272562000769 hinge residues; other site 272562000770 ABC-type nitrate/sulfonate/bicarbonate transport system, ATPase component [Inorganic ion transport and metabolism]; Region: TauB; COG1116 272562000771 ATP-binding cassette domain of the nitrate and sulfonate transporters; Region: ABC_NrtD_SsuB_transporters; cd03293 272562000772 Walker A/P-loop; other site 272562000773 ATP binding site [chemical binding]; other site 272562000774 Q-loop/lid; other site 272562000775 ABC transporter signature motif; other site 272562000776 Walker B; other site 272562000777 D-loop; other site 272562000778 H-loop/switch region; other site 272562000779 ABC-type nitrate/sulfonate/bicarbonate transport system, permease component [Inorganic ion transport and metabolism]; Region: TauC; COG0600 272562000780 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 272562000781 dimer interface [polypeptide binding]; other site 272562000782 conserved gate region; other site 272562000783 putative PBP binding loops; other site 272562000784 ABC-ATPase subunit interface; other site 272562000785 3'-phosphoadenosine 5'-phosphosulfate sulfotransferase (PAPS reductase)/FAD synthetase and related enzymes [Amino acid transport and metabolism / Coenzyme metabolism]; Region: CysH; COG0175 272562000786 This domain is found in phosphoadenosine phosphosulphate (PAPS) reductase enzymes or PAPS sulphotransferase. PAPS reductase is part of the adenine nucleotide alpha hydrolases superfamily also including N type ATP PPases and ATP sulphurylases. A highly...; Region: PAPS_reductase; cd01713 272562000787 Active Sites [active] 272562000788 GTPases - Sulfate adenylate transferase subunit 1 [Inorganic ion transport and metabolism]; Region: CysN; COG2895 272562000789 CysN, together with protein CysD, forms the ATP sulfurylase (ATPS) complex; Region: CysN_ATPS; cd04166 272562000790 CysD dimerization site [polypeptide binding]; other site 272562000791 G1 box; other site 272562000792 putative GEF interaction site [polypeptide binding]; other site 272562000793 GTP/Mg2+ binding site [chemical binding]; other site 272562000794 Switch I region; other site 272562000795 G2 box; other site 272562000796 G3 box; other site 272562000797 Switch II region; other site 272562000798 G4 box; other site 272562000799 G5 box; other site 272562000800 CysN_NodQ_II: This subfamily represents the domain II of the large subunit of ATP sulfurylase (ATPS): CysN or the N-terminal portion of NodQ, found mainly in proteobacteria and homologous to the domain II of EF-Tu. Escherichia coli ATPS consists of CysN...; Region: CysN_NodQ_II; cd03695 272562000801 TCysN_NoDQ_II: This subfamily represents the domain II of the large subunit of ATP sulfurylase (ATPS): CysN or the N-terminal portion of NodQ, found mainly in proteobacteria and homologous to the domain II of EF-Tu. Escherichia coli ATPS consists of CysN...; Region: CysN_NoDQ_III; cd04095 272562000802 Nucleoside/nucleotide kinase (NK) is a protein superfamily consisting of multiple families of enzymes that share structural similarity and are functionally related to the catalysis of the reversible phosphate group transfer from nucleoside triphosphates...; Region: NK; cl17190 272562000803 Bacterial extracellular solute-binding proteins, family 3; Region: SBP_bac_3; pfam00497 272562000804 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 272562000805 substrate binding pocket [chemical binding]; other site 272562000806 membrane-bound complex binding site; other site 272562000807 hinge residues; other site 272562000808 ABC-type amino acid transport system, permease component [Amino acid transport and metabolism]; Region: HisM; COG0765 272562000809 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 272562000810 dimer interface [polypeptide binding]; other site 272562000811 conserved gate region; other site 272562000812 putative PBP binding loops; other site 272562000813 ABC-ATPase subunit interface; other site 272562000814 ABC-type polar amino acid transport system, ATPase component [Amino acid transport and metabolism]; Region: GlnQ; COG1126 272562000815 ATP-binding cassette domain of the histidine and glutamine transporters; Region: ABC_HisP_GlnQ; cd03262 272562000816 Walker A/P-loop; other site 272562000817 ATP binding site [chemical binding]; other site 272562000818 Q-loop/lid; other site 272562000819 ABC transporter signature motif; other site 272562000820 Walker B; other site 272562000821 D-loop; other site 272562000822 H-loop/switch region; other site 272562000823 Transcriptional regulators of sugar metabolism [Transcription / Carbohydrate transport and metabolism]; Region: GlpR; COG1349 272562000824 DeoR-like helix-turn-helix domain; Region: HTH_DeoR; cl17531 272562000825 DeoR C terminal sensor domain; Region: DeoRC; pfam00455 272562000826 Predicted membrane-bound metal-dependent hydrolase (DUF457); Region: DUF457; pfam04307 272562000827 Predicted transcriptional regulator [Transcription]; Region: COG1959 272562000828 Rrf2 family protein; Region: rrf2_super; TIGR00738 272562000829 Carbon monoxide dehydrogenase (CODH) is found in acetogenic and methanogenic organisms and is responsible for the synthesis and breakdown of acetyl-CoA, respectively. CODH has two types of metal clusters, a cubane [Fe4-S4] center (B-cluster) similar to...; Region: CODH; cd01915 272562000830 ACS interaction site; other site 272562000831 CODH interaction site; other site 272562000832 cubane metal cluster (B-cluster) [ion binding]; other site 272562000833 Ni-Fe-S cluster (C-cluster) [ion binding]; other site 272562000834 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 272562000835 active site 272562000836 phosphorylation site [posttranslational modification] 272562000837 intermolecular recognition site; other site 272562000838 dimerization interface [polypeptide binding]; other site 272562000839 Chemotaxis protein histidine kinase and related kinases [Cell motility and secretion / Signal transduction mechanisms]; Region: CheA; COG0643 272562000840 Histidine Phosphotransfer domain, involved in signalling through a two part component systems in which an autophosphorylating histidine protein kinase serves as a phosphoryl donor to a response regulator protein; the response regulator protein is...; Region: HPT; cd00088 272562000841 putative binding surface; other site 272562000842 active site 272562000843 P2 response regulator binding domain; Region: P2; pfam07194 272562000844 Signal transducing histidine kinase, homodimeric domain; Region: H-kinase_dim; pfam02895 272562000845 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 272562000846 ATP binding site [chemical binding]; other site 272562000847 Mg2+ binding site [ion binding]; other site 272562000848 G-X-G motif; other site 272562000849 CheW-like domain. CheW proteins are part of the chemotaxis signalling mechanism in bacteria. CheW interacts with the methyl accepting chemotaxis proteins (MCPs) and relays signals to CheY, which affects flageller rotation. This family includes CheW and...; Region: CheW_like; cl00256 272562000850 Chemotaxis signal transduction protein [Cell motility and secretion / Signal transduction mechanisms]; Region: CheW; COG0835 272562000851 Four helix bundle sensory module for signal transduction; Region: 4HB_MCP_1; pfam12729 272562000852 Methyl-accepting chemotaxis protein [Cell motility and secretion / Signal transduction mechanisms]; Region: Tar; COG0840 272562000853 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 272562000854 dimerization interface [polypeptide binding]; other site 272562000855 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 272562000856 dimer interface [polypeptide binding]; other site 272562000857 putative CheW interface [polypeptide binding]; other site 272562000858 Methylase of chemotaxis methyl-accepting proteins [Cell motility and secretion / Signal transduction mechanisms]; Region: CheR; COG1352 272562000859 CheR methyltransferase, SAM binding domain; Region: CheR; pfam01739 272562000860 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 272562000861 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 272562000862 active site 272562000863 phosphorylation site [posttranslational modification] 272562000864 intermolecular recognition site; other site 272562000865 dimerization interface [polypeptide binding]; other site 272562000866 Nucleoside deaminases include adenosine, guanine and cytosine deaminases. These enzymes are Zn dependent and catalyze the deamination of nucleosides. The zinc ion in the active site plays a central role in the proposed catalytic mechanism, activating a...; Region: nucleoside_deaminase; cd01285 272562000867 nucleoside/Zn binding site; other site 272562000868 dimer interface [polypeptide binding]; other site 272562000869 catalytic motif [active] 272562000870 DNA polymerase III subunits gamma and tau; Validated; Region: PRK05563 272562000871 DNA polymerase III subunit delta'; Validated; Region: PRK08485 272562000872 DNA polymerase III subunits gamma and tau domain III; Region: DNA_pol3_gamma3; pfam12169 272562000873 DNA polymerase III gamma and tau subunits C terminal; Region: DUF3646; pfam12362 272562000874 hypothetical protein; Validated; Region: PRK00153 272562000875 recombination protein RecR; Reviewed; Region: recR; PRK00076 272562000876 RecR protein; Region: RecR; pfam02132 272562000877 TOPRIM_recR: topoisomerase-primase (TOPRIM) nucleotidyl transferase/hydrolase domain of the type found in Escherichia coli RecR. RecR participates in the RecFOR pathway of homologous recombinational repair in prokaryotes. This pathway provides a...; Region: TOPRIM_recR; cd01025 272562000878 putative active site [active] 272562000879 putative metal-binding site [ion binding]; other site 272562000880 tetramer interface [polypeptide binding]; other site 272562000881 Protein of unknown function (DUF2508); Region: DUF2508; pfam10704 272562000882 SigmaK-factor processing regulatory protein BofA; Region: BofA; pfam07441 272562000883 putative sporulation protein YtaF; Region: spore_YtaF; TIGR02840 272562000884 Domain of unknown function DUF; Region: DUF204; pfam02659 272562000885 ABC-type multidrug transport system, ATPase component [Defense mechanisms]; Region: CcmA; COG1131 272562000886 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 272562000887 Walker A/P-loop; other site 272562000888 ATP binding site [chemical binding]; other site 272562000889 Q-loop/lid; other site 272562000890 ABC transporter signature motif; other site 272562000891 Walker B; other site 272562000892 D-loop; other site 272562000893 H-loop/switch region; other site 272562000894 ABC-type transport system involved in multi-copper enzyme maturation, permease component [General function prediction only]; Region: NosY; COG1277 272562000895 ABC-type transport system involved in multi-copper enzyme maturation, permease component [General function prediction only]; Region: NosY; COG1277 272562000896 HlyD family secretion protein; Region: HlyD_3; pfam13437 272562000897 DNA-binding protein, stimulates sugar fermentation [General function prediction only]; Region: SfsA; COG1489 272562000898 NTP pyrophosphohydrolases containing a Zn-finger, probably nucleic-acid-binding [DNA replication, recombination, and repair]; Region: NPY1; COG2816 272562000899 NADH pyrophosphatase, a member of the Nudix hydrolase superfamily, catalyzes the cleavage of NADH into reduced nicotinamide mononucleotide (NMNH) and AMP. Like other members of the Nudix family, it requires a divalent cation, such as Mg2+ or Mn2+, for...; Region: NADH_pyrophosphatase; cd03429 272562000900 putative NADH binding site [chemical binding]; other site 272562000901 putative active site [active] 272562000902 nudix motif; other site 272562000903 putative metal binding site [ion binding]; other site 272562000904 Apolipophorin-III and similar insect proteins; Region: ApoLp-III_like; cl19113 272562000905 ABC-2 family transporter protein; Region: ABC2_membrane_2; pfam12679 272562000906 ABC-type multidrug transport system, ATPase component [Defense mechanisms]; Region: CcmA; COG1131 272562000907 ATP-binding cassette domain of the drug resistance transporter and related proteins, subfamily A; Region: ABC_DR_subfamily_A; cd03230 272562000908 Walker A/P-loop; other site 272562000909 ATP binding site [chemical binding]; other site 272562000910 Q-loop/lid; other site 272562000911 ABC transporter signature motif; other site 272562000912 Walker B; other site 272562000913 D-loop; other site 272562000914 H-loop/switch region; other site 272562000915 Class I aldolases; Region: Aldolase_Class_I; cl17187 272562000916 Protein of unknown function (DUF4230); Region: DUF4230; pfam14014 272562000917 Methyltransferase domain; Region: Methyltransf_31; pfam13847 272562000918 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 272562000919 S-adenosylmethionine binding site [chemical binding]; other site 272562000920 Acetyltransferases, including N-acetylases of ribosomal proteins [Translation, ribosomal structure and biogenesis]; Region: RimL; COG1670 272562000921 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl17182 272562000922 Predicted phosphatase/phosphohexomutase [General function prediction only]; Region: COG0637 272562000923 haloacid dehalogenase-like hydrolase; Region: HAD; cl19137 272562000924 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 272562000925 motif II; other site 272562000926 Phosphotransferase system, mannitol-specific IIBC component [Carbohydrate transport and metabolism]; Region: MtlA; COG2213 272562000927 PTS system, mannitol-specific IIC component; Region: mtlA; TIGR00851 272562000928 PTS_IIB_mannitol: subunit IIB of enzyme II (EII) of the mannitol-specific phosphoenolpyruvate:carbohydrate phosphotransferase system (PTS). In this system, EII is a mannitol-specific permease with two cytoplasmic domains (IIA and IIB) and a transmembrane...; Region: PTS_IIB_mannitol; cd05567 272562000929 active site 272562000930 P-loop; other site 272562000931 phosphorylation site [posttranslational modification] 272562000932 Transcriptional antiterminator [Transcription]; Region: BglG; COG3711 272562000933 PRD domain; Region: PRD; pfam00874 272562000934 PRD domain; Region: PRD; pfam00874 272562000935 PTS_IIB_bgl_like: the PTS (phosphotransferase system) IIB domain of a family of sensory systems composed of a membrane-bound sugar-sensor (similar to BglF) and a transcription antiterminator (similar to BglG) which regulate expression of genes involved...; Region: PTS_IIB_bgl_like; cd05568 272562000936 active site 272562000937 P-loop; other site 272562000938 phosphorylation site [posttranslational modification] 272562000939 PTS_IIA, PTS system, fructose/mannitol specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_fru; cl00163 272562000940 active site 272562000941 phosphorylation site [posttranslational modification] 272562000942 PTS_IIA, PTS system, fructose/mannitol specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_fru; cd00211 272562000943 active site 272562000944 phosphorylation site [posttranslational modification] 272562000945 mannitol-1-phosphate 5-dehydrogenase; Provisional; Region: PRK02318 272562000946 Mannitol dehydrogenase Rossmann domain; Region: Mannitol_dh; pfam01232 272562000947 Mannitol dehydrogenase C-terminal domain; Region: Mannitol_dh_C; pfam08125 272562000948 glucosamine--fructose-6-phosphate aminotransferase; Reviewed; Region: PRK00331 272562000949 Glutamine amidotransferases class-II (Gn-AT)_GFAT-type. This domain is found at the N-terminus of glucosamine-6P synthase (GlmS, or GFAT in humans). The glutaminase domain catalyzes amide nitrogen transfer from glutamine to the appropriate substrate. In...; Region: GFAT; cd00714 272562000950 glutaminase active site [active] 272562000951 SIS (Sugar ISomerase) domain repeat 1 found in Glucosamine 6-phosphate synthase (GlmS) and Glucosamine-6-phosphate deaminase (GlmD). The SIS domain is found in many phosphosugar isomerases and phosphosugar binding proteins. GlmS contains a N-terminal...; Region: SIS_GlmS_GlmD_1; cd05008 272562000952 dimer interface [polypeptide binding]; other site 272562000953 active site 272562000954 SIS (Sugar ISomerase) domain repeat 2 found in Glucosamine 6-phosphate synthase (GlmS) and Glucosamine-6-phosphate deaminase (GlmD). The SIS domain is found in many phosphosugar isomerases and phosphosugar binding proteins. GlmS contains a N-terminal...; Region: SIS_GlmS_GlmD_2; cd05009 272562000955 dimer interface [polypeptide binding]; other site 272562000956 active site 272562000957 TIGR04076 family protein; Region: TIGR04076 272562000958 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 272562000959 Coenzyme A binding pocket [chemical binding]; other site 272562000960 Cyanate permease [Inorganic ion transport and metabolism]; Region: CynX; COG2807 272562000961 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 272562000962 putative substrate translocation pore; other site 272562000963 Transcriptional regulators [Transcription]; Region: MarR; COG1846 272562000964 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 272562000965 putative Zn2+ binding site [ion binding]; other site 272562000966 putative DNA binding site [nucleotide binding]; other site 272562000967 ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136 272562000968 ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255 272562000969 Walker A/P-loop; other site 272562000970 ATP binding site [chemical binding]; other site 272562000971 Q-loop/lid; other site 272562000972 ABC transporter signature motif; other site 272562000973 Walker B; other site 272562000974 D-loop; other site 272562000975 H-loop/switch region; other site 272562000976 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG1978 272562000977 Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067 272562000978 catalytic core [active] 272562000979 Ribonuclease BN family enzyme [Replication, recombination, and repair]; Region: Rbn; COG1295 272562000980 ABC-type multidrug transport system, ATPase component [Defense mechanisms]; Region: CcmA; COG1131 272562000981 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 272562000982 Walker A/P-loop; other site 272562000983 ATP binding site [chemical binding]; other site 272562000984 Q-loop/lid; other site 272562000985 ABC transporter signature motif; other site 272562000986 Walker B; other site 272562000987 D-loop; other site 272562000988 H-loop/switch region; other site 272562000989 ABC-2 family transporter protein; Region: ABC2_membrane_3; pfam12698 272562000990 ABC-2 type transporter; Region: ABC2_membrane; cl17235 272562000991 ABC-type multidrug transport system, permease component [Defense mechanisms]; Region: COG0842 272562000992 ABC-2 type transporter; Region: ABC2_membrane; cl17235 272562000993 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: COG4585 272562000994 Histidine kinase; Region: HisKA_3; pfam07730 272562000995 Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase; Region: HATPase_c; pfam02518 272562000996 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 272562000997 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 272562000998 active site 272562000999 phosphorylation site [posttranslational modification] 272562001000 intermolecular recognition site; other site 272562001001 dimerization interface [polypeptide binding]; other site 272562001002 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 272562001003 DNA binding residues [nucleotide binding] 272562001004 dimerization interface [polypeptide binding]; other site 272562001005 N-acetylmuramic acid 6-phosphate etherase; Region: TIGR00274 272562001006 N-acetylmuramic acid 6-phosphate etherase. Members of this family contain the SIS (Sugar ISomerase) domain. The SIS domain is found in many phosphosugar isomerases and phosphosugar binding proteins. The bacterial cell wall sugar N-acetylmuramic acid...; Region: SIS_Etherase; cd05007 272562001007 putative active site [active] 272562001008 ABC-type dipeptide transport system, periplasmic component [Amino acid transport and metabolism]; Region: DdpA; COG0747 272562001009 The substrate-binding domain of an ABC-type nickel/oligopeptide-like import system contains the type 2 periplasmic binding fold; Region: PBP2_NikA_DppA_OppA_like; cd00995 272562001010 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppB; COG0601 272562001011 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 272562001012 dimer interface [polypeptide binding]; other site 272562001013 conserved gate region; other site 272562001014 putative PBP binding loops; other site 272562001015 ABC-ATPase subunit interface; other site 272562001016 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppC; COG1173 272562001017 N-terminal TM domain of oligopeptide transport permease C; Region: OppC_N; pfam12911 272562001018 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 272562001019 dimer interface [polypeptide binding]; other site 272562001020 conserved gate region; other site 272562001021 putative PBP binding loops; other site 272562001022 ABC-ATPase subunit interface; other site 272562001023 ABC-type dipeptide/oligopeptide/nickel transport system, ATPase component [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppD; COG0444 272562001024 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 272562001025 Walker A/P-loop; other site 272562001026 ATP binding site [chemical binding]; other site 272562001027 Q-loop/lid; other site 272562001028 ABC transporter signature motif; other site 272562001029 Walker B; other site 272562001030 D-loop; other site 272562001031 H-loop/switch region; other site 272562001032 oligopeptide/dipeptide ABC transporter, ATP-binding protein, C-terminal domain; Region: oligo_HPY; TIGR01727 272562001033 oligopeptide ABC transporter ATP-binding protein OppF; Provisional; Region: PRK15079 272562001034 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 272562001035 Walker A/P-loop; other site 272562001036 ATP binding site [chemical binding]; other site 272562001037 Q-loop/lid; other site 272562001038 ABC transporter signature motif; other site 272562001039 Walker B; other site 272562001040 D-loop; other site 272562001041 H-loop/switch region; other site 272562001042 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097 272562001043 Beta-lactamase; Region: Beta-lactamase; pfam00144 272562001044 Beta-glucosidase-related glycosidases [Carbohydrate transport and metabolism]; Region: BglX; COG1472 272562001045 Glycosyl hydrolase family 3 C-terminal domain; Region: Glyco_hydro_3_C; cl08459 272562001046 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cd00012 272562001047 nucleotide binding site [chemical binding]; other site 272562001048 Acetyltransferases [General function prediction only]; Region: RimI; COG0456 272562001049 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 272562001050 Coenzyme A binding pocket [chemical binding]; other site 272562001051 ribosomal-protein-alanine acetyltransferase; Region: rimI; TIGR01575 272562001052 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 272562001053 Coenzyme A binding pocket [chemical binding]; other site 272562001054 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3876 272562001055 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 272562001056 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 272562001057 non-specific DNA binding site [nucleotide binding]; other site 272562001058 salt bridge; other site 272562001059 sequence-specific DNA binding site [nucleotide binding]; other site 272562001060 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 272562001061 binding surface 272562001062 TPR motif; other site 272562001063 Tetratricopeptide repeat; Region: TPR_12; pfam13424 272562001064 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 272562001065 binding surface 272562001066 Tetratricopeptide repeat; Region: TPR_12; pfam13424 272562001067 TPR motif; other site 272562001068 Tetratricopeptide repeat; Region: TPR_12; pfam13424 272562001069 GlcN6P_deaminase: Glucosamine-6-phosphate (GlcN6P) deaminase subfamily; GlcN6P deaminase catalyzes the reversible conversion of GlcN6P to D-fructose-6-phosphate (Fru6P) and ammonium. The reaction is an aldo-keto isomerization coupled with an amination or...; Region: GlcN6P_deaminase; cd01399 272562001070 active site 272562001071 trimer interface [polypeptide binding]; other site 272562001072 allosteric site; other site 272562001073 active site lid [active] 272562001074 hexamer (dimer of trimers) interface [polypeptide binding]; other site 272562001075 N-acetylglucosamine-6-phosphate deacetylase [Carbohydrate transport and metabolism]; Region: NagA; COG1820 272562001076 N-acetylglucosamine-6-phosphate deacetylase, NagA, catalyzes the hydrolysis of the N-acetyl group of N-acetyl-glucosamine-6-phosphate (GlcNAc-6-P) to glucosamine 6-phosphate and acetate. This is the first committed step in the biosynthetic pathway to...; Region: NagA; cd00854 272562001077 active site 272562001078 dimer interface [polypeptide binding]; other site 272562001079 Transcriptional regulators [Transcription]; Region: PhnF; COG2188 272562001080 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 272562001081 DNA-binding site [nucleotide binding]; DNA binding site 272562001082 UTRA domain; Region: UTRA; pfam07702 272562001083 Beta-lactamase class A [Defense mechanisms]; Region: PenP; COG2367 272562001084 Beta-lactamase enzyme family; Region: Beta-lactamase2; pfam13354 272562001085 Transcriptional regulators [Transcription]; Region: RpiR; COG1737 272562001086 Helix-turn-helix domain, rpiR family; Region: HTH_6; pfam01418 272562001087 RpiR-like protein. RpiR contains a SIS (Sugar ISomerase) domain, which is found in many phosphosugar isomerases and phosphosugar binding proteins. In E. coli, rpiR negatively regulates the expression of rpiB gene. Both rpiB and rpiA are ribose phosphate...; Region: SIS_RpiR; cd05013 272562001088 putative active site [active] 272562001089 L-alanine-DL-glutamate epimerase and related enzymes of enolase superfamily [Cell envelope biogenesis, outer membrane / General function prediction only]; Region: COG4948 272562001090 L-Ala-D/L-Glu epimerase catalyzes the epimerization of L-Ala-D/L-Glu and other dipeptides. The genomic context and the substrate specificity of characterized members of this family from E.coli and B.subtilis indicates a possible role in the metabolism of...; Region: L-Ala-DL-Glu_epimerase; cd03319 272562001091 active site 272562001092 4-amino-4-deoxy-L-arabinose transferase and related glycosyltransferases of PMT family [Cell envelope biogenesis, outer membrane]; Region: ArnT; COG1807 272562001093 Dolichyl-phosphate-mannose-protein mannosyltransferase; Region: PMT_2; pfam13231 272562001094 undecaprenyl phosphate 4-deoxy-4-formamido-L-arabinose transferase; Provisional; Region: PRK10714 272562001095 Bacterial DPM1_like enzymes are related to eukaryotic DPM1; Region: DPM1_like_bac; cd04187 272562001096 Ligand binding site; other site 272562001097 Putative Catalytic site; other site 272562001098 DXD motif; other site 272562001099 Predicted transcriptional regulators [Transcription]; Region: COG1733 272562001100 Old yellow enzyme (OYE)-like FMN binding domain. OYE was the first flavin-dependent enzyme identified, however its true physiological role remains elusive to this day. Each monomer of OYE contains FMN as a non-covalently bound cofactor, uses NADPH as a...; Region: OYE_like_FMN_family; cd02803 272562001101 active site 272562001102 FMN binding site [chemical binding]; other site 272562001103 substrate binding site [chemical binding]; other site 272562001104 putative catalytic residue [active] 272562001105 Transcriptional regulators [Transcription]; Region: MarR; COG1846 272562001106 helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347 272562001107 dimerization interface [polypeptide binding]; other site 272562001108 putative Zn2+ binding site [ion binding]; other site 272562001109 putative DNA binding site [nucleotide binding]; other site 272562001110 Predicted membrane protein [Function unknown]; Region: COG2364 272562001111 Predicted membrane protein [Function unknown]; Region: COG2717 272562001112 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 272562001113 Bacterial regulatory proteins, tetR family; Region: TetR_N; cl19382 272562001114 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 272562001115 flavodoxin; Provisional; Region: PRK06242 272562001116 Sortase D (SrtD) is a membrane transpeptidase found in gram-positive bacteria that anchors surface proteins to peptidoglycans of the bacterial cell wall envelope. This involves a transpeptidation reaction in which the surface protein substrate is cleaved...; Region: Sortase_D_5; cd06166 272562001117 active site 272562001118 catalytic site [active] 272562001119 metallophosphatase superfamily, metallophosphatase domain; Region: MPP_superfamily; cl13995 272562001120 active site 272562001121 metal binding site [ion binding]; metal-binding site 272562001122 LPXTG-motif cell wall anchor domain; Region: LPXTG_anchor; TIGR01167 272562001123 Predicted multitransmembrane protein [Function unknown]; Region: COG5438 272562001124 amidase; Provisional; Region: PRK11910 272562001125 biotin synthase; Region: bioB; TIGR00433 272562001126 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 272562001127 FeS/SAM binding site; other site 272562001128 Biotin and Thiamin Synthesis associated domain; Region: BATS; pfam06968 272562001129 Uncharacterized conserved protein [General function prediction only]; Region: BioY; COG1268 272562001130 Biotin operon repressor [Transcription]; Region: BirA; COG1654 272562001131 Biotin-(acetyl-CoA carboxylase) ligase [Coenzyme metabolism]; Region: BirA; COG0340 272562001132 Biotin/lipoate A/B protein ligase family; Region: BPL_LplA_LipB; pfam03099 272562001133 Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118 272562001134 M42 Peptidase, Endoglucanases; Region: M42_Frv; cd05656 272562001135 oligomer interface [polypeptide binding]; other site 272562001136 active site 272562001137 metal binding site [ion binding]; metal-binding site 272562001138 M42 Peptidase, Endoglucanases; Region: M42_Frv; cd05656 272562001139 oligomer interface [polypeptide binding]; other site 272562001140 active site 272562001141 metal binding site [ion binding]; metal-binding site 272562001142 Cellulase M and related proteins [Carbohydrate transport and metabolism]; Region: FrvX; COG1363 272562001143 metal binding site [ion binding]; metal-binding site 272562001144 Prephenate dehydratase [Amino acid transport and metabolism]; Region: PheA; COG0077 272562001145 Prephenate dehydratase; Region: PDT; pfam00800 272562001146 C-terminal ACT domain of the bifunctional chorismate mutase-prephenate dehydratase (CM-PDT) enzyme and the prephenate dehydratase (PDT) enzyme; Region: ACT_CM-PDT; cd04905 272562001147 putative L-Phe binding site [chemical binding]; other site 272562001148 Family 4 Uracil-DNA glycosylase (UDG), found exclusively in thermophilic organisms; Region: UDG_F4_TTUDGA_like; cd10030 272562001149 active site 272562001150 Fe-S cluster binding site [ion binding]; other site 272562001151 Clostripain family; Region: Peptidase_C11; pfam03415 272562001152 Serine-pyruvate aminotransferase/archaeal aspartate aminotransferase [Amino acid transport and metabolism]; Region: COG0075 272562001153 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 272562001154 catalytic residue [active] 272562001155 Human Ape1-like subfamily of the ExoIII family purinic/apyrimidinic (AP) endonucleases; Region: Ape1-like_AP-endo; cd09087 272562001156 active site 272562001157 putative catalytic site [active] 272562001158 DNA binding site [nucleotide binding] 272562001159 putative phosphate binding site [ion binding]; other site 272562001160 metal binding site A [ion binding]; metal-binding site 272562001161 AP binding site [nucleotide binding]; other site 272562001162 metal binding site B [ion binding]; metal-binding site 272562001163 Predicted N6-adenine-specific DNA methylase [DNA replication, recombination, and repair]; Region: COG0116 272562001164 THUMP domain associated with S-adenosylmethionine-dependent methyltransferases; Region: THUMP_AdoMetMT; cd11715 272562001165 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl17173 272562001166 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 272562001167 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 272562001168 active site 272562001169 phosphorylation site [posttranslational modification] 272562001170 intermolecular recognition site; other site 272562001171 dimerization interface [polypeptide binding]; other site 272562001172 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 272562001173 DNA binding site [nucleotide binding] 272562001174 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 272562001175 His Kinase A (phosphoacceptor) domain; Region: HisKA; smart00388 272562001176 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 272562001177 ATP binding site [chemical binding]; other site 272562001178 Mg2+ binding site [ion binding]; other site 272562001179 G-X-G motif; other site 272562001180 ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136 272562001181 ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255 272562001182 Walker A/P-loop; other site 272562001183 ATP binding site [chemical binding]; other site 272562001184 Q-loop/lid; other site 272562001185 ABC transporter signature motif; other site 272562001186 Walker B; other site 272562001187 D-loop; other site 272562001188 H-loop/switch region; other site 272562001189 ABC-type antimicrobial peptide transport system, permease component [Defense mechanisms]; Region: SalY; COG0577 272562001190 FtsX-like permease family; Region: FtsX; pfam02687 272562001191 Predicted Zn-dependent proteases and their inactivated homologs [General function prediction only]; Region: TldD; COG0312 272562001192 Predicted Zn-dependent proteases and their inactivated homologs [General function prediction only]; Region: TldD; COG0312 272562001193 Transcriptional regulators of sugar metabolism [Transcription / Carbohydrate transport and metabolism]; Region: GlpR; COG1349 272562001194 helix_turn_helix, Deoxyribose operon repressor; Region: HTH_DEOR; smart00420 272562001195 DeoR C terminal sensor domain; Region: DeoRC; pfam00455 272562001196 1-phosphofructokinase (FruK), minor 6-phosphofructokinase (pfkB) and related sugar kinases. FruK plays an important role in the predominant pathway for fructose utilisation.This group also contains tagatose-6-phophate kinase, an enzyme of the tagatose...; Region: FruK_PfkB_like; cd01164 272562001197 putative substrate binding site [chemical binding]; other site 272562001198 putative ATP binding site [chemical binding]; other site 272562001199 PTS_IIA, PTS system, fructose/mannitol specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_fru; cd00211 272562001200 active site 272562001201 phosphorylation site [posttranslational modification] 272562001202 putative PTS system transporter subunits IIBC; Provisional; Region: PRK11404 272562001203 PTS_IIB_fructose: subunit IIB of enzyme II (EII) of the fructose-specific phosphoenolpyruvate:carbohydrate phosphotransferase system (PTS). In this system, EII (also referred to as FruAB) is a fructose-specific permease made up of two proteins (FruA and...; Region: PTS_IIB_fructose; cd05569 272562001204 active site 272562001205 P-loop; other site 272562001206 phosphorylation site [posttranslational modification] 272562001207 Phosphotransferase system, fructose-specific IIC component [Carbohydrate transport and metabolism]; Region: FruA; COG1299 272562001208 Chloramphenicol O-acetyltransferase [Defense mechanisms]; Region: COG4845 272562001209 ABC-type multidrug transport system, ATPase component [Defense mechanisms]; Region: CcmA; COG1131 272562001210 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 272562001211 Walker A/P-loop; other site 272562001212 ATP binding site [chemical binding]; other site 272562001213 Q-loop/lid; other site 272562001214 ABC transporter signature motif; other site 272562001215 Walker B; other site 272562001216 D-loop; other site 272562001217 H-loop/switch region; other site 272562001218 ABC-type multidrug transport system, permease component [Defense mechanisms]; Region: COG0842 272562001219 ABC-2 type transporter; Region: ABC2_membrane; cl17235 272562001220 ABC-type multidrug transport system, permease component [Defense mechanisms]; Region: COG0842 272562001221 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: COG4585 272562001222 Histidine kinase; Region: HisKA_3; pfam07730 272562001223 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 272562001224 ATP binding site [chemical binding]; other site 272562001225 Mg2+ binding site [ion binding]; other site 272562001226 G-X-G motif; other site 272562001227 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 272562001228 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 272562001229 active site 272562001230 phosphorylation site [posttranslational modification] 272562001231 intermolecular recognition site; other site 272562001232 dimerization interface [polypeptide binding]; other site 272562001233 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 272562001234 DNA binding residues [nucleotide binding] 272562001235 dimerization interface [polypeptide binding]; other site 272562001236 ABC-type multidrug transport system, ATPase component [Defense mechanisms]; Region: CcmA; COG1131 272562001237 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 272562001238 Walker A/P-loop; other site 272562001239 ATP binding site [chemical binding]; other site 272562001240 Q-loop/lid; other site 272562001241 ABC transporter signature motif; other site 272562001242 Walker B; other site 272562001243 D-loop; other site 272562001244 H-loop/switch region; other site 272562001245 ABC-2 family transporter protein; Region: ABC2_membrane_3; pfam12698 272562001246 ABC-2 type transporter; Region: ABC2_membrane; cl17235 272562001247 ABC-2 family transporter protein; Region: ABC2_membrane_3; pfam12698 272562001248 ABC-2 type transporter; Region: ABC2_membrane; pfam01061 272562001249 ABC-type transport system, involved in lipoprotein release, permease component [Cell envelope biogenesis, outer membrane]; Region: LolE; COG4591 272562001250 MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704 272562001251 FtsX-like permease family; Region: FtsX; pfam02687 272562001252 ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136 272562001253 ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255 272562001254 Walker A/P-loop; other site 272562001255 ATP binding site [chemical binding]; other site 272562001256 Q-loop/lid; other site 272562001257 ABC transporter signature motif; other site 272562001258 Walker B; other site 272562001259 D-loop; other site 272562001260 H-loop/switch region; other site 272562001261 Predicted permeases [General function prediction only]; Region: COG0730 272562001262 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3328 272562001263 Transposase, Mutator family; Region: Transposase_mut; cl19537 272562001264 This conserved domain belongs to a superfamily including the bleomycin resistance protein, glyoxalase I, and type I ring-cleaving dioxygenases; Region: Glo_EDI_BRP_like_1; cd08352 272562001265 putative metal binding site [ion binding]; other site 272562001266 Cache domain; Region: Cache_1; pfam02743 272562001267 HAMP domain; Region: HAMP; pfam00672 272562001268 Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer); Region: MA; smart00283 272562001269 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cl19050 272562001270 dimer interface [polypeptide binding]; other site 272562001271 putative CheW interface [polypeptide binding]; other site 272562001272 Uncharacterized Fe-S protein [Energy production and conversion]; Region: COG1600 272562001273 Helix-turn-helix domain; Region: HTH_17; pfam12728 272562001274 Periplasmic molybdate-binding protein/domain [Inorganic ion transport and metabolism]; Region: COG1910 272562001275 NifH gene encodes component II (iron protein) of nitrogenase. Nitrogenase is responsible for the biological nitrogen fixation, i.e. reduction of molecular nitrogen to ammonia. NifH consists of two oxygen-sensitive metallosulfur proteins: the...; Region: NifH; cd02040 272562001276 nitrogenase iron protein; Region: nifH; TIGR01287 272562001277 Nucleotide-binding sites [chemical binding]; other site 272562001278 Walker A motif; other site 272562001279 Switch I region of nucleotide binding site; other site 272562001280 Fe4S4 binding sites [ion binding]; other site 272562001281 Switch II region of nucleotide binding site; other site 272562001282 Nitrogen regulatory protein P-II; Region: P-II; pfam00543 272562001283 Nitrogen regulatory protein PII [Amino acid transport and metabolism]; Region: GlnK; COG0347 272562001284 The nitrogenase enzyme system catalyzes the ATP-dependent reduction of dinitrogen to ammonia. This group contains both alpha and beta subunits of component 1 of the three known genetically distinct types of nitrogenase systems: a molybdenum-dependent; Region: Oxidoreductase_nitrogenase; cl02775 272562001285 Nitrogenase molybdenum-iron protein, alpha and beta chains [Energy production and conversion]; Region: NifD; COG2710 272562001286 Nitrogenase molybdenum-iron protein, alpha and beta chains [Energy production and conversion]; Region: NifD; COG2710 272562001287 The nitrogenase enzyme system catalyzes the ATP-dependent reduction of dinitrogen to ammonia. This group contains both alpha and beta subunits of component 1 of the three known genetically distinct types of nitrogenase systems: a molybdenum-dependent; Region: Oxidoreductase_nitrogenase; cl02775 272562001288 nitrogenase molybdenum-cofactor biosynthesis protein NifE; Provisional; Region: PRK14478 272562001289 Nitrogenase molybdenum-iron protein, alpha and beta chains [Energy production and conversion]; Region: NifD; COG2710 272562001290 Nitrogenase molybdenum-iron protein, alpha and beta chains [Energy production and conversion]; Region: NifD; COG2710 272562001291 The nitrogenase enzyme system catalyzes the ATP-dependent reduction of dinitrogen to ammonia. This group contains both alpha and beta subunits of component 1 of the three known genetically distinct types of nitrogenase systems: a molybdenum-dependent; Region: Oxidoreductase_nitrogenase; cl02775 272562001292 nitrogenase cofactor biosynthesis protein NifB; Region: nifB; TIGR01290 272562001293 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 272562001294 FeS/SAM binding site; other site 272562001295 NifB belongs to a family of iron-molybdenum cluster-binding proteins that includes NifX, and NifY, all of which are involved in the synthesis of an iron-molybdenum cofactor (FeMo-co) that binds the active site of the dinitrogenase enzyme as part of...; Region: NifB; cd00852 272562001296 Isopropylmalate/homocitrate/citramalate synthases [Amino acid transport and metabolism]; Region: LeuA; COG0119 272562001297 DRE-TIM metallolyase superfamily; Region: DRE_TIM_metallolyase; cl18962 272562001298 metal binding site [ion binding]; metal-binding site 272562001299 DRE-TIM metallolyase superfamily; Region: DRE_TIM_metallolyase; cl18962 272562001300 active site 272562001301 catalytic residues [active] 272562001302 metal binding site [ion binding]; metal-binding site 272562001303 Tryptophan-rich sensory protein (mitochondrial benzodiazepine receptor homolog) [Signal transduction mechanisms]; Region: COG3476 272562001304 Phosphoserine phosphatase [Amino acid transport and metabolism]; Region: SerB; COG0560 272562001305 haloacid dehalogenase-like hydrolase; Region: Hydrolase; pfam00702 272562001306 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 272562001307 motif II; other site 272562001308 ABC-2 family transporter protein; Region: ABC2_membrane_4; pfam12730 272562001309 Predicted transcriptional regulators [Transcription]; Region: COG1725 272562001310 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 272562001311 DNA-binding site [nucleotide binding]; DNA binding site 272562001312 gallidermin-class lantibiotic protection ABC transporter, ATP-binding subunit; Region: galliderm_ABC; TIGR03740 272562001313 ATP-binding cassette domain of the drug resistance transporter and related proteins, subfamily A; Region: ABC_DR_subfamily_A; cd03230 272562001314 Walker A/P-loop; other site 272562001315 ATP binding site [chemical binding]; other site 272562001316 Q-loop/lid; other site 272562001317 ABC transporter signature motif; other site 272562001318 Walker B; other site 272562001319 D-loop; other site 272562001320 H-loop/switch region; other site 272562001321 L-lactate dehydrogenase; Reviewed; Region: ldh; PRK00066 272562001322 A subgroup of L-lactate dehydrogenases; Region: LDH_2; cd05292 272562001323 NAD binding site [chemical binding]; other site 272562001324 dimer interface [polypeptide binding]; other site 272562001325 substrate binding site [chemical binding]; other site 272562001326 tetramer (dimer of dimers) interface [polypeptide binding]; other site 272562001327 ABC-type Na+ transport system, ATPase component [Energy production and conversion / Inorganic ion transport and metabolism]; Region: NatA; COG4555 272562001328 ATP-binding cassette domain of the drug resistance transporter and related proteins, subfamily A; Region: ABC_DR_subfamily_A; cd03230 272562001329 Walker A/P-loop; other site 272562001330 ATP binding site [chemical binding]; other site 272562001331 Q-loop/lid; other site 272562001332 ABC transporter signature motif; other site 272562001333 Walker B; other site 272562001334 D-loop; other site 272562001335 H-loop/switch region; other site 272562001336 4-hydroxybenzoyl-CoA thioesterase (4HBT). Catalyzes the final step in the 4-chlorobenzoate degradation pathway in which 4-chlorobenzoate is converted to 4-hydroxybenzoate in certain soil-dwelling bacteria. 4HBT forms a homotetramer with four active sites; Region: 4HBT; cd00586 272562001337 active site 272562001338 Amino acid transporters [Amino acid transport and metabolism]; Region: PotE; COG0531 272562001339 2-isopropylmalate synthase; Validated; Region: PRK03739 272562001340 Mycobacterium tuberculosis LeuA3 and related proteins, N-terminal catalytic TIM barrel domain; Region: DRE_TIM_LeuA; cd07942 272562001341 active site 272562001342 catalytic residues [active] 272562001343 metal binding site [ion binding]; metal-binding site 272562001344 LeuA allosteric (dimerisation) domain; Region: LeuA_dimer; smart00917 272562001345 aspartate ammonia-lyase; Provisional; Region: PRK13353 272562001346 Aspartase; Region: Aspartase; cd01357 272562001347 active sites [active] 272562001348 tetramer interface [polypeptide binding]; other site 272562001349 c-di-GMP phosphodiesterase class II (HD-GYP domain) [Signal transduction mechanisms]; Region: COG2206 272562001350 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 272562001351 Zn2+ binding site [ion binding]; other site 272562001352 Mg2+ binding site [ion binding]; other site 272562001353 aspartate kinase; Reviewed; Region: PRK09034 272562001354 AAK_AKiii-YclM-BS: Amino Acid Kinase Superfamily (AAK), AKiii-YclM-BS; this CD includes the N-terminal catalytic aspartokinase (AK) domain of the lysine plus threonine-sensitive aspartokinase isoenzyme AKIII, a monofunctional class enzyme found in...; Region: AAK_AKiii-YclM-BS; cd04245 272562001355 putative catalytic residues [active] 272562001356 putative nucleotide binding site [chemical binding]; other site 272562001357 putative aspartate binding site [chemical binding]; other site 272562001358 ACT domains located C-terminal to the catalytic domain of the lysine plus threonine-sensitive aspartokinase isoenzyme AKIII; Region: ACT_AKiii-YclM-BS_1; cd04911 272562001359 allosteric regulatory residue; other site 272562001360 ACT domains located C-terminal to the catalytic domain of the lysine plus threonine-sensitive aspartokinase isoenzyme AKIII; Region: ACT_AKiii-YclM-BS_2; cd04916 272562001361 nitrogen fixation protein NifM; Region: nifM_nitrog; TIGR02933 272562001362 PPIC-type PPIASE domain; Region: Rotamase; pfam00639 272562001363 ABC-type sulfate transport system, permease component [Posttranslational modification, protein turnover, chaperones]; Region: CysU; COG0555 272562001364 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 272562001365 dimer interface [polypeptide binding]; other site 272562001366 conserved gate region; other site 272562001367 putative PBP binding loops; other site 272562001368 ABC-ATPase subunit interface; other site 272562001369 ABC-type molybdate transport system, periplasmic component [Inorganic ion transport and metabolism]; Region: ModA; COG0725 272562001370 Guanine deaminase (GDEase). Guanine deaminase is an aminohydrolase responsible for the conversion of guanine to xanthine and ammonia, the first step to utilize guanine as a nitrogen source. This reaction also removes the guanine base from the pool and...; Region: GDEase; cd01303 272562001371 guanine deaminase; Region: guan_deamin; TIGR02967 272562001372 active site 272562001373 MogA_MoaB family. Members of this family are involved in biosynthesis of the molybdenum cofactor (MoCF) an essential cofactor of a diverse group of redox enzymes. MoCF biosynthesis is an evolutionarily conserved pathway present in eubacteria, archaea; Region: MogA_MoaB; cd00886 272562001374 MPT binding site; other site 272562001375 trimer interface [polypeptide binding]; other site 272562001376 NAD-dependent deacetylase; Provisional; Region: PRK00481 272562001377 Nucleotidyltransferase/DNA polymerase involved in DNA repair [DNA replication, recombination, and repair]; Region: DinP; COG0389 272562001378 DNA Polymerase IV/Kappa; Region: PolY_Pol_IV_kappa; cd03586 272562001379 active site 272562001380 DNA binding site [nucleotide binding] 272562001381 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4200 272562001382 ABC-2 family transporter protein; Region: ABC2_membrane_4; pfam12730 272562001383 ATP-binding cassette domain of the bacitracin-resistance transporter; Region: ABC_BcrA_bacitracin_resist; cd03268 272562001384 gallidermin-class lantibiotic protection ABC transporter, ATP-binding subunit; Region: galliderm_ABC; TIGR03740 272562001385 Walker A/P-loop; other site 272562001386 ATP binding site [chemical binding]; other site 272562001387 Q-loop/lid; other site 272562001388 ABC transporter signature motif; other site 272562001389 Walker B; other site 272562001390 D-loop; other site 272562001391 H-loop/switch region; other site 272562001392 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 272562001393 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 272562001394 active site 272562001395 phosphorylation site [posttranslational modification] 272562001396 intermolecular recognition site; other site 272562001397 dimerization interface [polypeptide binding]; other site 272562001398 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 272562001399 DNA binding site [nucleotide binding] 272562001400 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 272562001401 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 272562001402 dimer interface [polypeptide binding]; other site 272562001403 phosphorylation site [posttranslational modification] 272562001404 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 272562001405 ATP binding site [chemical binding]; other site 272562001406 Mg2+ binding site [ion binding]; other site 272562001407 G-X-G motif; other site 272562001408 Methionine synthase I (cobalamin-dependent), methyltransferase domain [Amino acid transport and metabolism]; Region: MetH; COG0646 272562001409 bifunctional homocysteine S-methyltransferase/5,10-methylenetetrahydrofolate reductase protein; Reviewed; Region: PRK08645 272562001410 Methylenetetrahydrofolate reductase (MTHFR). 5,10-Methylenetetrahydrofolate is reduced to 5-methyltetrahydrofolate by methylenetetrahydrofolate reductase, a cytoplasmic, NAD(P)-dependent enzyme. 5-methyltetrahydrofolate is utilized by methionine synthase...; Region: MTHFR; cd00537 272562001411 FAD binding site [chemical binding]; other site 272562001412 Protein of unknown function (DUF3006); Region: DUF3006; pfam11213 272562001413 LD-Carboxypeptidase, a serine protease, includes microcin C7 self immunity protein; Region: Peptidase_S66; cd07025 272562001414 dimer interface [polypeptide binding]; other site 272562001415 catalytic triad [active] 272562001416 CorA-like Mg2+ transporter protein; Region: CorA; pfam01544 272562001417 uncharacterized bacterial subfamily of the Escherichia coli CorA-Salmonella typhimurium ZntB family; Region: EcCorA_ZntB-like_u2; cd12827 272562001418 Cl binding site [ion binding]; other site 272562001419 oligomer interface [polypeptide binding]; other site 272562001420 Metal-dependent amidase/aminoacylase/carboxypeptidase [General function prediction only]; Region: AbgB; COG1473 272562001421 Zinc peptidases M18, M20, M28, and M42; Region: Zinc_peptidase_like; cl14876 272562001422 metal binding site [ion binding]; metal-binding site 272562001423 Inhibitor of sigma-G Gin; Region: Gin; pfam10764 272562001424 Arginine/lysine/ornithine decarboxylases [Amino acid transport and metabolism]; Region: LdcC; COG1982 272562001425 Ornithine decarboxylase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD corresponds to ornithine decarboxylase (ODC), arginine decarboxylase (ADC) and lysine...; Region: Orn_deC_like; cd00615 272562001426 homodimer interface [polypeptide binding]; other site 272562001427 pyridoxal 5'-phosphate binding site [chemical binding]; other site 272562001428 catalytic residue [active] 272562001429 Orn/Lys/Arg decarboxylase, C-terminal domain; Region: OKR_DC_1_C; pfam03711 272562001430 Guanylate kinase [Nucleotide transport and metabolism]; Region: Gmk; COG0194 272562001431 active site 272562001432 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3870 272562001433 DNA polymerase III subunit delta'; Validated; Region: PRK05564 272562001434 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 272562001435 Walker A motif; other site 272562001436 ATP binding site [chemical binding]; other site 272562001437 Walker B motif; other site 272562001438 arginine finger; other site 272562001439 Uncharacterized homolog of PSP1 [Function unknown]; Region: COG1774 272562001440 Heavy-metal-associated domain (HMA) is a conserved domain of approximately 30 amino acid residues found in a number of proteins that transport or detoxify heavy metals, for example, the CPx-type heavy metal ATPases and copper chaperones. HMA domain...; Region: HMA; cd00371 272562001441 metal-binding site [ion binding] 272562001442 The HCP family of iron-sulfur proteins includes hybrid cluster protein (HCP), acetyl-CoA synthase (ACS), and carbon monoxide dehydrogenase (CODH), all of which contain [Fe4-S4] metal clusters at their active sites. These proteins have a conserved...; Region: HCP_like; cl19102 272562001443 4Fe-4S dicluster domain; Region: Fer4_7; pfam12838 272562001444 Flagellar motor component [Cell motility and secretion]; Region: MotA; COG1291 272562001445 Flagellar motor protein [Cell motility and secretion]; Region: MotB; COG1360 272562001446 Membrane MotB of proton-channel complex MotA/MotB; Region: MotB_plug; pfam13677 272562001447 Peptidoglycan binding domains similar to the C-terminal domain of outer-membrane protein OmpA; Region: OmpA_C-like; cd07185 272562001448 ligand binding site [chemical binding]; other site 272562001449 Predicted O-methyltransferase [General function prediction only]; Region: COG4123 272562001450 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 272562001451 S-adenosylmethionine binding site [chemical binding]; other site 272562001452 Ribosomal RNA small subunit methyltransferase I, also known as rRNA (cytidine-2'-O-)-methyltransferase RsmI; Region: RsmI; cd11648 272562001453 putative SAM binding site [chemical binding]; other site 272562001454 putative homodimer interface [polypeptide binding]; other site 272562001455 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3883 272562001456 The Bin/Amphiphysin/Rvs (BAR) domain, a dimerization module that binds membranes and detects membrane curvature; Region: BAR; cl12013 272562001457 Cell wall-associated hydrolases (invasion-associated proteins) [Cell envelope biogenesis, outer membrane]; Region: Spr; COG0791 272562001458 NlpC/P60 family; Region: NLPC_P60; pfam00877 272562001459 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3883 272562001460 Cell wall-associated hydrolases (invasion-associated proteins) [Cell envelope biogenesis, outer membrane]; Region: Spr; COG0791 272562001461 Parvovirus coat protein VP2; Region: Parvo_coat; pfam00740 272562001462 NlpC/P60 family; Region: NLPC_P60; pfam00877 272562001463 Regulators of stationary/sporulation gene expression [Transcription]; Region: AbrB; COG2002 272562001464 tRNA nucleotidyltransferase/poly(A) polymerase [Translation, ribosomal structure and biogenesis]; Region: PcnB; COG0617 272562001465 Nucleotidyltransferase (NT) domain of ClassII CCA-adding enzymes; Region: NT_ClassII-CCAase; cd05398 272562001466 active site 272562001467 NTP binding site [chemical binding]; other site 272562001468 metal binding triad [ion binding]; metal-binding site 272562001469 Probable RNA and SrmB- binding site of polymerase A; Region: PolyA_pol_RNAbd; pfam12627 272562001470 CRISPR/Cas system-associated protein Cas3'' Region: Cas3''_I; cl17503 272562001471 Apolipophorin-III and similar insect proteins; Region: ApoLp-III_like; cl19113 272562001472 Phage shock protein A (IM30), suppresses sigma54-dependent transcription [Transcription / Signal transduction mechanisms]; Region: PspA; COG1842 272562001473 Domain of unknown function (DUF1836); Region: DUF1836; pfam08876 272562001474 Predicted acetyltransferase [General function prediction only]; Region: COG3981 272562001475 Acetyltransferase (GNAT) domain; Region: Acetyltransf_3; pfam13302 272562001476 ornithine carbamoyltransferase; Validated; Region: PRK02102 272562001477 Aspartate/ornithine carbamoyltransferase, carbamoyl-P binding domain; Region: OTCace_N; pfam02729 272562001478 Aspartate/ornithine carbamoyltransferase, Asp/Orn binding domain; Region: OTCace; pfam00185 272562001479 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 272562001480 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 272562001481 dimerization interface [polypeptide binding]; other site 272562001482 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 272562001483 dimer interface [polypeptide binding]; other site 272562001484 phosphorylation site [posttranslational modification] 272562001485 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 272562001486 ATP binding site [chemical binding]; other site 272562001487 Mg2+ binding site [ion binding]; other site 272562001488 G-X-G motif; other site 272562001489 RND family efflux transporter, MFP subunit; Region: RND_mfp; TIGR01730 272562001490 HlyD family secretion protein; Region: HlyD_3; pfam13437 272562001491 ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255 272562001492 ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136 272562001493 Walker A/P-loop; other site 272562001494 ATP binding site [chemical binding]; other site 272562001495 Q-loop/lid; other site 272562001496 ABC transporter signature motif; other site 272562001497 Walker B; other site 272562001498 D-loop; other site 272562001499 H-loop/switch region; other site 272562001500 MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704 272562001501 ABC-type antimicrobial peptide transport system, permease component [Defense mechanisms]; Region: SalY; COG0577 272562001502 FtsX-like permease family; Region: FtsX; pfam02687 272562001503 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 272562001504 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 272562001505 active site 272562001506 phosphorylation site [posttranslational modification] 272562001507 intermolecular recognition site; other site 272562001508 dimerization interface [polypeptide binding]; other site 272562001509 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 272562001510 DNA binding site [nucleotide binding] 272562001511 EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2). The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948 272562001512 Dolichyl-phosphate-mannose-protein mannosyltransferase; Region: PMT_2; cl19158 272562001513 phosphate regulon sensor kinase PhoR; Region: phoR_proteo; TIGR02966 272562001514 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 272562001515 dimer interface [polypeptide binding]; other site 272562001516 phosphorylation site [posttranslational modification] 272562001517 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 272562001518 ATP binding site [chemical binding]; other site 272562001519 Mg2+ binding site [ion binding]; other site 272562001520 G-X-G motif; other site 272562001521 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 272562001522 non-specific DNA binding site [nucleotide binding]; other site 272562001523 salt bridge; other site 272562001524 sequence-specific DNA binding site [nucleotide binding]; other site 272562001525 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 272562001526 binding surface 272562001527 TPR motif; other site 272562001528 Predicted membrane protein [Function unknown]; Region: COG1971 272562001529 Domain of unknown function DUF; Region: DUF204; pfam02659 272562001530 recombination factor protein RarA; Reviewed; Region: PRK13342 272562001531 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 272562001532 Walker A motif; other site 272562001533 ATP binding site [chemical binding]; other site 272562001534 Walker B motif; other site 272562001535 arginine finger; other site 272562001536 MgsA AAA+ ATPase C terminal; Region: MgsA_C; pfam12002 272562001537 Peroxiredoxin [Posttranslational modification, protein turnover, chaperones]; Region: AhpC; COG0450 272562001538 Peroxiredoxin (PRX) family, Bacterioferritin comigratory protein (BCP) subfamily; composed of thioredoxin-dependent thiol peroxidases, widely expressed in pathogenic bacteria, that protect cells against toxicity from reactive oxygen species by reducing...; Region: PRX_BCP; cd03017 272562001539 catalytic triad [active] 272562001540 Protein of unknown function DUF45; Region: DUF45; pfam01863 272562001541 Cell division protein FtsI/penicillin-binding protein 2 [Cell envelope biogenesis, outer membrane]; Region: FtsI; COG0768 272562001542 Penicillin-binding Protein dimerization domain; Region: PBP_dimer; pfam03717 272562001543 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; pfam00905 272562001544 prolipoprotein diacylglyceryl transferase; Reviewed; Region: PRK12437 272562001545 Predicted membrane protein [Function unknown]; Region: COG4684 272562001546 Beta-mannanase [Carbohydrate transport and metabolism]; Region: ManB; COG4124 272562001547 LXG domain of WXG superfamily; Region: LXG; pfam04740 272562001548 Apolipoprotein L; Region: ApoL; pfam05461 272562001549 NAD+--asparagine ADP-ribosyltransferase [Signal transduction mechanisms]; Region: COG5585 272562001550 A nuclease family of the HNH/ENDO VII superfamily with conserved AHH; Region: AHH; pfam14412 272562001551 NAD+--asparagine ADP-ribosyltransferase [Signal transduction mechanisms]; Region: COG5585 272562001552 Immunity protein Imm6; Region: Imm6; pfam14434 272562001553 Immunity protein Imm6; Region: Imm6; pfam14434 272562001554 NAD+--asparagine ADP-ribosyltransferase [Signal transduction mechanisms]; Region: COG5585 272562001555 VIP2; A family of actin-ADP-ribosylating toxin. A member of the Bacillus-prodiced vegetative insecticidal proteins (VIPs) possesses high specificity against the major insect pest, corn rootworms, and belongs to a classs of binary toxins and regulators of...; Region: VIP2; cd00233 272562001556 active site 272562001557 conformational flexibility of ligand binding pocket; other site 272562001558 ADP-ribosylating toxin turn-turn motif; other site 272562001559 ADP-ribosylglycohydrolase [Posttranslational modification, protein turnover, chaperones]; Region: DraG; COG1397 272562001560 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4304 272562001561 YdcF-like. YdcF-like is a large family of mainly bacterial proteins, with a few members found in fungi, plants, and archaea. Escherichia coli YdcF has been shown to bind S-adenosyl-L-methionine (AdoMet), but a biochemical function has not been...; Region: YdcF-like; cd06259 272562001562 putative active site [active] 272562001563 5'-nucleotidase/2',3'-cyclic phosphodiesterase and related esterases [Nucleotide transport and metabolism]; Region: UshA; COG0737 272562001564 Escherichia coli UshA-like family, N-terminal metallophosphatase domain; Region: MPP_UshA_N_like; cd00845 272562001565 active site 272562001566 metal binding site [ion binding]; metal-binding site 272562001567 5'-nucleotidase, C-terminal domain; Region: 5_nucleotid_C; pfam02872 272562001568 5'-nucleotidase/2',3'-cyclic phosphodiesterase and related esterases [Nucleotide transport and metabolism]; Region: UshA; COG0737 272562001569 Escherichia coli CpdB and related proteins, N-terminal metallophosphatase domain; Region: MPP_CpdB_N; cd07410 272562001570 active site 272562001571 metal binding site [ion binding]; metal-binding site 272562001572 5'-nucleotidase, C-terminal domain; Region: 5_nucleotid_C; pfam02872 272562001573 Predicted integral membrane protein [Function unknown]; Region: COG5542 272562001574 Endopygalactorunase [Cell envelope biogenesis, outer membrane]; Region: PGU1; COG5434 272562001575 Pectate lyase superfamily protein; Region: Pectate_lyase_3; cl19188 272562001576 Pectate lyase superfamily protein; Region: Pectate_lyase_3; cl19188 272562001577 Uncharacterized ACR, YkgG family COG1556; Region: DUF162; pfam02589 272562001578 Na+/melibiose symporter and related transporters [Carbohydrate transport and metabolism]; Region: MelB; COG2211 272562001579 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 272562001580 putative symporter YagG; Provisional; Region: PRK09669; cl15392 272562001581 Predicted xylanase/chitin deacetylase [Carbohydrate transport and metabolism]; Region: CDA1; COG0726 272562001582 Putative catalytic NodB homology domain of gellan lyase and similar proteins; Region: CE4_GLA_like_6s; cd10967 272562001583 putative active site [active] 272562001584 putative metal binding site [ion binding]; other site 272562001585 Predicted unsaturated glucuronyl hydrolase involved in regulation of bacterial surface properties, and related proteins [General function prediction only]; Region: COG4225 272562001586 Transcriptional regulators [Transcription]; Region: PurR; COG1609 272562001587 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 272562001588 DNA binding site [nucleotide binding] 272562001589 domain linker motif; other site 272562001590 Ligand binding domain of the LacI tanscriptional regulator family belonging to the type I periplasmic-binding fold protein superfamily; Region: PBP1_LacI_sugar_binding_like; cd06267 272562001591 dimerization interface [polypeptide binding]; other site 272562001592 ligand binding site [chemical binding]; other site 272562001593 2-deoxy-D-gluconate 3-dehydrogenase; Provisional; Region: PRK06935 272562001594 gluconate 5-dehydrogenase (Ga5DH)-like, classical (c) SDRs; Region: Ga5DH-like_SDR_c; cd05347 272562001595 NADP binding site [chemical binding]; other site 272562001596 homodimer interface [polypeptide binding]; other site 272562001597 active site 272562001598 Hemerythrin HHE cation binding domain; Region: Hemerythrin; pfam01814 272562001599 Endonuclease_V, a DNA repair enzyme that initiates repair of nitrosative deaminated purine bases; Region: Endonuclease_V; cd06559 272562001600 Active_site [active] 272562001601 Phosphoglycerate dehydrogenase and related dehydrogenases [Amino acid transport and metabolism]; Region: SerA; COG0111 272562001602 Phosphoglycerate Dehydrogenase, 2-hydroxyacid dehydrogenase family; Region: PGDH_1; cd12155 272562001603 putative ligand binding site [chemical binding]; other site 272562001604 NAD binding site [chemical binding]; other site 272562001605 catalytic site [active] 272562001606 Membrane transport protein; Region: Mem_trans; pfam03547 272562001607 M20 Peptidase Arginine utilization protein, RocB; Region: M20_ArgE_RocB; cd05654 272562001608 putative metal binding site [ion binding]; other site 272562001609 putative dimer interface [polypeptide binding]; other site 272562001610 Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610 272562001611 Adenosylmethionine-8-amino-7-oxononanoate aminotransferase [Coenzyme metabolism]; Region: BioA; COG0161 272562001612 inhibitor-cofactor binding pocket; inhibition site 272562001613 pyridoxal 5'-phosphate binding site [chemical binding]; other site 272562001614 catalytic residue [active] 272562001615 Acetyltransferase (GNAT) domain; Region: Acetyltransf_3; pfam13302 272562001616 Acetyltransferase (GNAT) family; Region: Acetyltransf_1; pfam00583 272562001617 Cation/multidrug efflux pump [Defense mechanisms]; Region: AcrB; COG0841 272562001618 MMPL family; Region: MMPL; cl14618 272562001619 MMPL family; Region: MMPL; cl14618 272562001620 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 272562001621 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 272562001622 active site 272562001623 phosphorylation site [posttranslational modification] 272562001624 intermolecular recognition site; other site 272562001625 dimerization interface [polypeptide binding]; other site 272562001626 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cl17355 272562001627 DNA binding site [nucleotide binding] 272562001628 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 272562001629 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 272562001630 ATP binding site [chemical binding]; other site 272562001631 Mg2+ binding site [ion binding]; other site 272562001632 G-X-G motif; other site 272562001633 ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136 272562001634 ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255 272562001635 Walker A/P-loop; other site 272562001636 ATP binding site [chemical binding]; other site 272562001637 Q-loop/lid; other site 272562001638 ABC transporter signature motif; other site 272562001639 Walker B; other site 272562001640 D-loop; other site 272562001641 H-loop/switch region; other site 272562001642 aminotransferase A; Validated; Region: PRK07683 272562001643 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 272562001644 pyridoxal 5'-phosphate binding site [chemical binding]; other site 272562001645 homodimer interface [polypeptide binding]; other site 272562001646 catalytic residue [active] 272562001647 N-Dimethylarginine dimethylaminohydrolase [Amino acid transport and metabolism]; Region: COG1834 272562001648 ABC-type amino acid transport system, permease component [Amino acid transport and metabolism]; Region: HisM; COG0765 272562001649 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 272562001650 dimer interface [polypeptide binding]; other site 272562001651 conserved gate region; other site 272562001652 putative PBP binding loops; other site 272562001653 ABC-ATPase subunit interface; other site 272562001654 ABC-type polar amino acid transport system, ATPase component [Amino acid transport and metabolism]; Region: GlnQ; COG1126 272562001655 ATP-binding cassette domain of the histidine and glutamine transporters; Region: ABC_HisP_GlnQ; cd03262 272562001656 Walker A/P-loop; other site 272562001657 ATP binding site [chemical binding]; other site 272562001658 Q-loop/lid; other site 272562001659 ABC transporter signature motif; other site 272562001660 Walker B; other site 272562001661 D-loop; other site 272562001662 H-loop/switch region; other site 272562001663 Transcriptional regulators [Transcription]; Region: GntR; COG1802 272562001664 DNA-binding site [nucleotide binding]; DNA binding site 272562001665 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cl17414 272562001666 FCD domain; Region: FCD; pfam07729 272562001667 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 272562001668 Bacterial extracellular solute-binding proteins, family 3; Region: SBP_bac_3; pfam00497 272562001669 substrate binding pocket [chemical binding]; other site 272562001670 membrane-bound complex binding site; other site 272562001671 hinge residues; other site 272562001672 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cl19050 272562001673 dimer interface [polypeptide binding]; other site 272562001674 putative CheW interface [polypeptide binding]; other site 272562001675 Adenosine deaminase z-alpha domain; Region: z-alpha; cl02659 272562001676 Transcriptional regulators containing an AAA-type ATPase domain and a DNA-binding domain [Transcription / Signal transduction mechanisms]; Region: PspF; COG1221 272562001677 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 272562001678 Walker A motif; other site 272562001679 ATP binding site [chemical binding]; other site 272562001680 Walker B motif; other site 272562001681 arginine finger; other site 272562001682 The GH18 (glycosyl hydrolase, family 18) type II chitinases hydrolyze chitin, an abundant polymer of beta-1,4-linked N-acetylglucosamine (GlcNAc) which is a major component of the cell wall of fungi and the exoskeleton of arthropods. Chitinases have...; Region: GH18_chitinase-like; cl10447 272562001683 Transcriptional antiterminator [Transcription]; Region: COG3933 272562001684 PRD domain; Region: PRD; pfam00874 272562001685 PTS_IIA, PTS system, mannose/sorbose specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIA_man; cd00006 272562001686 active pocket/dimerization site; other site 272562001687 active site 272562001688 phosphorylation site [posttranslational modification] 272562001689 PRD domain; Region: PRD; pfam00874 272562001690 PTS_IIA, PTS system, lactose/cellobiose specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_lac; cd00215 272562001691 active site 272562001692 methionine cluster; other site 272562001693 phosphorylation site [posttranslational modification] 272562001694 metal binding site [ion binding]; metal-binding site 272562001695 PTS_IIB_chitobiose_lichenan: subunit IIB of enzyme II (EII) of the N,N-diacetylchitobiose-specific and lichenan-specific phosphoenolpyruvate:carbohydrate phosphotransferase system (PTS). In these systems, EII is either a lichenan- or an N; Region: PTS_IIB_chitobiose_lichenan; cd05564 272562001696 active site 272562001697 P-loop; other site 272562001698 phosphorylation site [posttranslational modification] 272562001699 Beta-glucosidase/6-phospho-beta-glucosidase/beta- galactosidase [Carbohydrate transport and metabolism]; Region: BglB; COG2723 272562001700 Glycosyl hydrolase family 1; Region: Glyco_hydro_1; pfam00232 272562001701 Phosphotransferase system cellobiose-specific component IIC [Carbohydrate transport and metabolism]; Region: CelB; COG1455 272562001702 CGS_like: Cystathionine gamma-synthase is a PLP dependent enzyme and catalyzes the committed step of methionine biosynthesis. This pathway is unique to microorganisms and plants, rendering the enzyme an attractive target for the development of...; Region: CGS_like; cd00614 272562001703 homodimer interface [polypeptide binding]; other site 272562001704 substrate-cofactor binding pocket; other site 272562001705 pyridoxal 5'-phosphate binding site [chemical binding]; other site 272562001706 catalytic residue [active] 272562001707 CGS_like: Cystathionine gamma-synthase is a PLP dependent enzyme and catalyzes the committed step of methionine biosynthesis. This pathway is unique to microorganisms and plants, rendering the enzyme an attractive target for the development of...; Region: CGS_like; cd00614 272562001708 homodimer interface [polypeptide binding]; other site 272562001709 substrate-cofactor binding pocket; other site 272562001710 pyridoxal 5'-phosphate binding site [chemical binding]; other site 272562001711 catalytic residue [active] 272562001712 Putative peptidoglycan-binding domain-containing protein [Cell envelope biogenesis, outer membrane]; Region: COG3409 272562001713 Putative peptidoglycan binding domain; Region: PG_binding_1; pfam01471 272562001714 Transcriptional regulators [Transcription]; Region: PurR; COG1609 272562001715 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 272562001716 DNA binding site [nucleotide binding] 272562001717 domain linker motif; other site 272562001718 Ligand-binding domain of DNA transcription repressor RegR and other putative regulators such as KdgR and EndR; Region: PBP1_RegR_EndR_KdgR_like; cd06283 272562001719 putative dimerization interface [polypeptide binding]; other site 272562001720 putative ligand binding site [chemical binding]; other site 272562001721 KDPG and KHG aldolase; Region: KDPG_aldolase; cd00452 272562001722 Entner-Doudoroff aldolase; Region: eda; TIGR01182 272562001723 active site 272562001724 intersubunit interface [polypeptide binding]; other site 272562001725 catalytic residue [active] 272562001726 2-keto-3-deoxygluconate kinase (KdgK) phosphorylates 2-keto-3-deoxygluconate (KDG) to form 2-keto-3-deoxy-6-phosphogluconate (KDGP). KDG is the common intermediate product, that allows organisms to channel D-glucuronate and/or D-galacturinate into the...; Region: KdgK; cd01166 272562001727 substrate binding site [chemical binding]; other site 272562001728 ATP binding site [chemical binding]; other site 272562001729 3-Keto-L-gulonate 6-phosphate decarboxylase (KGPDC) and D-arabino-3-hexulose-6-phosphate synthase (HPS). KGPDC catalyzes the formation of L-xylulose 5-phosphate and carbon dioxide from 3-keto-L-gulonate 6-phosphate as part of the anaerobic pathway for...; Region: KGPDC_HPS; cd04726 272562001730 active site 272562001731 dimer interface [polypeptide binding]; other site 272562001732 magnesium binding site [ion binding]; other site 272562001733 Hexulose-6-phosphate isomerase (PHI). PHI is a member of the SIS (Sugar ISomerase domain) superfamily. In the ribulose monophosphate pathway of formaldehyde fixation, hexulose-6-phosphate synthase catalyzes the condensation of ribulose-5-phosphate with...; Region: SIS_PHI; cd05005 272562001734 Transcriptional regulators [Transcription]; Region: RpiR; COG1737 272562001735 tetramer interface [polypeptide binding]; other site 272562001736 active site 272562001737 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4842 272562001738 Bacterial Ig-like domain (group 3); Region: Big_3_3; pfam13750 272562001739 Bacterial Ig-like domain (group 3); Region: Big_3_4; pfam13754 272562001740 Bacterial Ig-like domain (group 3); Region: Big_3_4; pfam13754 272562001741 Bacterial Ig-like domain (group 3); Region: Big_3_4; pfam13754 272562001742 Protein Kinases, catalytic domain; Region: PKc_like; cl09925 272562001743 Protein kinase domain; Region: Pkinase; pfam00069 272562001744 active site 272562001745 ATP binding site [chemical binding]; other site 272562001746 substrate binding site [chemical binding]; other site 272562001747 activation loop (A-loop); other site 272562001748 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 272562001749 TPR motif; other site 272562001750 binding surface 272562001751 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 272562001752 binding surface 272562001753 TPR motif; other site 272562001754 FOG: FHA domain [Signal transduction mechanisms]; Region: COG1716 272562001755 Forkhead associated domain (FHA); found in eukaryotic and prokaryotic proteins. Putative nuclear signalling domain. FHA domains may bind phosphothreonine, phosphoserine and sometimes phosphotyrosine. In eukaryotes, many FHA domain-containing proteins...; Region: FHA; cd00060 272562001756 phosphopeptide binding site; other site 272562001757 Serine/threonine phosphatases, family 2C, catalytic domain; The protein architecture and deduced catalytic mechanism of PP2C phosphatases are similar to the PP1, PP2A, PP2B family of protein Ser/Thr phosphatases, with which PP2C shares no sequence...; Region: PP2Cc; cd00143 272562001758 active site 272562001759 FOG: FHA domain [Signal transduction mechanisms]; Region: COG1716 272562001760 Forkhead associated domain (FHA); found in eukaryotic and prokaryotic proteins. Putative nuclear signalling domain. FHA domains may bind phosphothreonine, phosphoserine and sometimes phosphotyrosine. In eukaryotes, many FHA domain-containing proteins...; Region: FHA; cd00060 272562001761 phosphopeptide binding site; other site 272562001762 type VII secretion protein EssC, C-terminal domain; Region: T7_EssCb_Firm; TIGR03928 272562001763 FtsK/SpoIIIE family; Region: FtsK_SpoIIIE; pfam01580 272562001764 FtsK/SpoIIIE family; Region: FtsK_SpoIIIE; pfam01580 272562001765 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 272562001766 Walker A motif; other site 272562001767 ATP binding site [chemical binding]; other site 272562001768 Walker B motif; other site 272562001769 WXG100 protein secretion system (Wss), protein YukD; Region: YukD; cl17489 272562001770 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4842 272562001771 WXG100 family type VII secretion target; Region: WXG100_ESAT6; TIGR03930 272562001772 TPR repeat; Region: TPR_11; pfam13414 272562001773 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 272562001774 binding surface 272562001775 TPR motif; other site 272562001776 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 272562001777 binding surface 272562001778 TPR motif; other site 272562001779 FOG: TPR repeat [General function prediction only]; Region: NrfG; COG0457 272562001780 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 272562001781 binding surface 272562001782 TPR motif; other site 272562001783 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4842 272562001784 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 272562001785 binding surface 272562001786 TPR motif; other site 272562001787 FOG: TPR repeat [General function prediction only]; Region: NrfG; COG0457 272562001788 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 272562001789 binding surface 272562001790 TPR motif; other site 272562001791 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 272562001792 binding surface 272562001793 TPR motif; other site 272562001794 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 272562001795 binding surface 272562001796 TPR motif; other site 272562001797 TPR repeat; Region: TPR_11; pfam13414 272562001798 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 272562001799 TPR repeat; Region: TPR_11; pfam13414 272562001800 binding surface 272562001801 TPR motif; other site 272562001802 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 272562001803 binding surface 272562001804 TPR motif; other site 272562001805 FOG: TPR repeat [General function prediction only]; Region: NrfG; COG0457 272562001806 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 272562001807 binding surface 272562001808 TPR motif; other site 272562001809 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 272562001810 binding surface 272562001811 TPR motif; other site 272562001812 Arsenate Reductase (ArsC) family; composed of TRX-fold arsenic reductases and similar proteins including the transcriptional regulator, Spx. ArsC catalyzes the reduction of arsenate [As(V)] to arsenite [As(III)], using reducing equivalents derived from...; Region: ArsC_family; cd02977 272562001813 catalytic residue [active] 272562001814 Predicted phosphatases [General function prediction only]; Region: Gph; COG0546 272562001815 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 272562001816 active site 272562001817 motif I; other site 272562001818 motif II; other site 272562001819 Predicted metal-dependent membrane protease [General function prediction only]; Region: COG1266 272562001820 Protein of unknown function (DUF3816); Region: DUF3816; pfam12822 272562001821 transcriptional antiterminator BglG; Provisional; Region: PRK09772 272562001822 CAT RNA binding domain; Region: CAT_RBD; smart01061 272562001823 PRD domain; Region: PRD; pfam00874 272562001824 PRD domain; Region: PRD; pfam00874 272562001825 PTS system, sucrose-specific IIBC component; Region: PTS-II-BC-sucr; TIGR01996 272562001826 PTS_IIB, PTS system, glucose/sucrose specific IIB subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIB_glc; cd00212 272562001827 active site turn [active] 272562001828 phosphorylation site [posttranslational modification] 272562001829 Phosphotransferase system IIC components, glucose/maltose/N-acetylglucosamine-specific [Carbohydrate transport and metabolism]; Region: PtsG; COG1263 272562001830 Phosphotransferase system IIA components [Carbohydrate transport and metabolism]; Region: NagE; COG2190 272562001831 HPr interaction site; other site 272562001832 glycerol kinase (GK) interaction site [polypeptide binding]; other site 272562001833 active site 272562001834 phosphorylation site [posttranslational modification] 272562001835 Fructokinases (FRKs) mainly from bacteria and plants are enzymes with high specificity for fructose, as are all FRKs, but they catalyzes the conversion of fructose to fructose-6-phosphate, which is an entry point into glycolysis via conversion into...; Region: bac_FRK; cd01167 272562001836 putative substrate binding site [chemical binding]; other site 272562001837 putative ATP binding site [chemical binding]; other site 272562001838 sucrose-6-phosphate hydrolase; Region: scrB_fam; TIGR01322 272562001839 Glycosyl hydrolase family 32, beta-fructosidases; Region: GH32_B_Fructosidase; cd08996 272562001840 substrate binding [chemical binding]; other site 272562001841 active site 272562001842 Glycosyl hydrolases family 32 C terminal; Region: Glyco_hydro_32C; pfam08244 272562001843 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 272562001844 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 272562001845 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 272562001846 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3708 272562001847 ABC-type sulfate transport system, permease component [Posttranslational modification, protein turnover, chaperones]; Region: CysU; COG0555 272562001848 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 272562001849 dimer interface [polypeptide binding]; other site 272562001850 conserved gate region; other site 272562001851 putative PBP binding loops; other site 272562001852 ABC-ATPase subunit interface; other site 272562001853 ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395 272562001854 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 272562001855 dimer interface [polypeptide binding]; other site 272562001856 conserved gate region; other site 272562001857 putative PBP binding loops; other site 272562001858 ABC-ATPase subunit interface; other site 272562001859 ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653 272562001860 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; cl17199 272562001861 Glycerophosphoryl diester phosphodiesterase [Energy production and conversion]; Region: UgpQ; COG0584 272562001862 Glycerophosphodiester phosphodiesterase domain of Thermoanaerobacter tengcongensis and similar proteins; Region: GDPD_TtGDE_like; cd08563 272562001863 active site 272562001864 catalytic site [active] 272562001865 metal binding site [ion binding]; metal-binding site 272562001866 dimer interface [polypeptide binding]; other site 272562001867 Uncharacterized conserved protein [Function unknown]; Region: COG1284 272562001868 Uncharacterized BCR, YitT family COG1284; Region: DUF161; pfam02588 272562001869 Uncharacterized BCR, YitT family COG1284; Region: DUF161; pfam02588 272562001870 Uncharacterized protein conserved in bacteria (DUF2179); Region: DUF2179; pfam10035 272562001871 Predicted sensor domain [Signal transduction mechanisms / Transcription]; Region: PocR; COG4936 272562001872 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cl19050 272562001873 dimer interface [polypeptide binding]; other site 272562001874 putative CheW interface [polypeptide binding]; other site 272562001875 Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer); Region: MA; smart00283 272562001876 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cl19050 272562001877 dimer interface [polypeptide binding]; other site 272562001878 putative CheW interface [polypeptide binding]; other site 272562001879 MECDP_synthase (2-C-methyl-D-erythritol-2,4-cyclodiphosphate synthase), encoded by the ispF gene, catalyzes the formation of 2-C-methyl-D-erythritol 2,4-cyclodiphosphate (MEC) in the non-mevalonate deoxyxylulose (DOXP) pathway for isoprenoid biosynthesis; Region: MECDP_synthase; cd00554 272562001880 homotrimer interaction site [polypeptide binding]; other site 272562001881 zinc binding site [ion binding]; other site 272562001882 CDP-binding sites; other site 272562001883 Predicted xylanase/chitin deacetylase [Carbohydrate transport and metabolism]; Region: CDA1; COG0726 272562001884 Putative catalytic NodB homology domain of PgaB, IcaB, and similar proteins which consist of a deformed (beta/alpha)8 barrel fold with 5- or 6-strands; Region: CE4_NodB_like_5s_6s; cd10918 272562001885 putative active site [active] 272562001886 putative metal binding site [ion binding]; other site 272562001887 FOG: PAS/PAC domain [Signal transduction mechanisms]; Region: AtoS; COG2202 272562001888 PAS domain; Region: PAS; smart00091 272562001889 phosphate regulon sensor kinase PhoR; Region: phoR_proteo; TIGR02966 272562001890 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 272562001891 dimer interface [polypeptide binding]; other site 272562001892 phosphorylation site [posttranslational modification] 272562001893 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 272562001894 ATP binding site [chemical binding]; other site 272562001895 Mg2+ binding site [ion binding]; other site 272562001896 G-X-G motif; other site 272562001897 Predicted periplasmic or secreted lipoprotein [General function prediction only]; Region: OsmY; COG2823 272562001898 BON domain; Region: BON; pfam04972 272562001899 BON domain; Region: BON; pfam04972 272562001900 YdcF-like. YdcF-like is a large family of mainly bacterial proteins, with a few members found in fungi, plants, and archaea. Escherichia coli YdcF has been shown to bind S-adenosyl-L-methionine (AdoMet), but a biochemical function has not been...; Region: YdcF-like; cd06259 272562001901 putative active site [active] 272562001902 CLC voltage-gated chloride channel. The ClC chloride channels catalyse the selective flow of Cl- ions across cell membranes, thereby regulating electrical excitation in skeletal muscle and the flow of salt and water across epithelial barriers. This...; Region: Voltage_gated_ClC; cd00400 272562001903 Cl- selectivity filter; other site 272562001904 Cl- binding residues [ion binding]; other site 272562001905 pore gating glutamate residue; other site 272562001906 dimer interface [polypeptide binding]; other site 272562001907 ligand binding domain of Tar- and Tsr-related chemoreceptors; Region: Tar_Tsr_LBD; cl00144 272562001908 Methyl-accepting chemotaxis protein [Cell motility and secretion / Signal transduction mechanisms]; Region: Tar; COG0840 272562001909 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 272562001910 dimerization interface [polypeptide binding]; other site 272562001911 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cl19050 272562001912 dimer interface [polypeptide binding]; other site 272562001913 putative CheW interface [polypeptide binding]; other site 272562001914 Kef-type K+ transport systems, membrane components [Inorganic ion transport and metabolism]; Region: KefB; COG0475 272562001915 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 272562001916 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cl17315 272562001917 DNA binding residues [nucleotide binding] 272562001918 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3860 272562001919 Members of the Nudix hydrolase superfamily catalyze the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+, for their activity and contain a highly...; Region: Nudix_Hydrolase_33; cd04692 272562001920 nudix motif; other site 272562001921 Fe2+ transport system protein A [Inorganic ion transport and metabolism]; Region: FeoA; COG1918 272562001922 Fe2+ transport system protein B [Inorganic ion transport and metabolism]; Region: FeoB; COG0370 272562001923 Ferrous iron transport protein B (FeoB) family; Region: FeoB; cd01879 272562001924 G1 box; other site 272562001925 GTP/Mg2+ binding site [chemical binding]; other site 272562001926 Switch I region; other site 272562001927 G2 box; other site 272562001928 G3 box; other site 272562001929 Switch II region; other site 272562001930 G4 box; other site 272562001931 G5 box; other site 272562001932 Nucleoside recognition; Region: Gate; pfam07670 272562001933 Ferrous iron transport protein B C terminus; Region: FeoB_C; pfam07664 272562001934 Nucleoside recognition; Region: Gate; pfam07670 272562001935 Protein of unknown function (DUF3189); Region: DUF3189; pfam11385 272562001936 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 272562001937 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 272562001938 active site 272562001939 phosphorylation site [posttranslational modification] 272562001940 intermolecular recognition site; other site 272562001941 dimerization interface [polypeptide binding]; other site 272562001942 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 272562001943 DNA binding site [nucleotide binding] 272562001944 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 272562001945 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 272562001946 dimerization interface [polypeptide binding]; other site 272562001947 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 272562001948 dimer interface [polypeptide binding]; other site 272562001949 phosphorylation site [posttranslational modification] 272562001950 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 272562001951 ATP binding site [chemical binding]; other site 272562001952 Mg2+ binding site [ion binding]; other site 272562001953 G-X-G motif; other site 272562001954 ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136 272562001955 ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255 272562001956 Walker A/P-loop; other site 272562001957 ATP binding site [chemical binding]; other site 272562001958 Q-loop/lid; other site 272562001959 ABC transporter signature motif; other site 272562001960 Walker B; other site 272562001961 D-loop; other site 272562001962 H-loop/switch region; other site 272562001963 ABC-type transport system, involved in lipoprotein release, permease component [Cell envelope biogenesis, outer membrane]; Region: LolE; COG4591 272562001964 MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704 272562001965 FtsX-like permease family; Region: FtsX; pfam02687 272562001966 ABC-type antimicrobial peptide transport system, permease component [Defense mechanisms]; Region: SalY; COG0577 272562001967 FtsX-like permease family; Region: FtsX; pfam02687 272562001968 Lipoxygenase; Region: Lipoxygenase; pfam00305 272562001969 ATP-dependent Lon protease, bacterial type [Posttranslational modification, protein turnover, chaperones]; Region: Lon; COG0466 272562001970 ATP-dependent protease La (LON) domain; Region: LON; pfam02190 272562001971 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 272562001972 Walker A motif; other site 272562001973 ATP binding site [chemical binding]; other site 272562001974 Walker B motif; other site 272562001975 arginine finger; other site 272562001976 Lon protease (S16) C-terminal proteolytic domain; Region: Lon_C; pfam05362 272562001977 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 272562001978 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 272562001979 H+ Antiporter protein; Region: 2A0121; TIGR00900 272562001980 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 272562001981 putative substrate translocation pore; other site 272562001982 Propionate catabolism activator; Region: PrpR_N; pfam06506 272562001983 Transcriptional regulator containing PAS, AAA-type ATPase, and DNA-binding domains [Transcription / Signal transduction mechanisms]; Region: RocR; COG3829 272562001984 PAS domain; Region: PAS; smart00091 272562001985 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 272562001986 Walker A motif; other site 272562001987 ATP binding site [chemical binding]; other site 272562001988 Walker B motif; other site 272562001989 arginine finger; other site 272562001990 Bacterial regulatory protein, Fis family; Region: HTH_8; cl17420 272562001991 Hemolysins and related proteins containing CBS domains [General function prediction only]; Region: TlyC; COG1253 272562001992 Domain of unknown function DUF21; Region: DUF21; pfam01595 272562001993 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains associated with the CorC_HlyC domain. CorC_HlyC is a transporter associated domain. This small domain is found in Na+/H+ antiporters, in proteins involved in...; Region: CBS_pair_CorC_HlyC_assoc; cd04590 272562001994 Transporter associated domain; Region: CorC_HlyC; pfam03471 272562001995 Helix-Turn-Helix DNA binding domain of Heavy Metal Resistance transcription regulators; Region: HTH_HMRTR; cd04770 272562001996 Predicted transcriptional regulators [Transcription]; Region: SoxR; COG0789 272562001997 DNA binding residues [nucleotide binding] 272562001998 dimer interface [polypeptide binding]; other site 272562001999 metal binding site [ion binding]; metal-binding site 272562002000 Uncharacterized paraquat-inducible protein B [Function unknown]; Region: COG3007 272562002001 NAD(P)H binding domain of trans-2-enoyl-CoA reductase; Region: Eno-Rase_NADH_b; pfam12242 272562002002 Trans-2-enoyl-CoA reductase catalytic region; Region: Enoyl_reductase; pfam12241 272562002003 Enoyl reductase FAD binding domain; Region: Eno-Rase_FAD_bd; pfam07055 272562002004 periplasmic serine pepetdase DegS; Region: protease_degS; TIGR02038 272562002005 Trypsin-like peptidase domain; Region: Trypsin_2; pfam13365 272562002006 PDZ domain of trypsin-like serine proteases, such as DegP/HtrA, which are oligomeric proteins involved in heat-shock response, chaperone function, and apoptosis. May be responsible for substrate recognition and/or binding, as most PDZ domains bind...; Region: PDZ_serine_protease; cd00987 272562002007 protein binding site [polypeptide binding]; other site 272562002008 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3323 272562002009 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 272562002010 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 272562002011 non-specific DNA binding site [nucleotide binding]; other site 272562002012 salt bridge; other site 272562002013 sequence-specific DNA binding site [nucleotide binding]; other site 272562002014 Protein of unknown function (DUF2837); Region: DUF2837; pfam10997 272562002015 haloacid dehalogenase superfamily, subfamily IA, variant 3 with third motif having DD or ED; Region: HAD-SF-IA-v3; TIGR01509 272562002016 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 272562002017 motif II; other site 272562002018 Uncharacterized membrane protein, required for spore maturation in B.subtilis. [General function prediction only]; Region: SpmA; COG2715 272562002019 Uncharacterized membrane protein [Function unknown]; Region: SpmB; COG0700 272562002020 Molecular chaperone GrpE (heat shock protein) [Posttranslational modification, protein turnover, chaperones]; Region: GrpE; COG0576 272562002021 dimer interface [polypeptide binding]; other site 272562002022 hsp70 (ATPase domain) interactions [polypeptide binding]; other site 272562002023 Molecular chaperone [Posttranslational modification, protein turnover, chaperones]; Region: DnaK; COG0443 272562002024 Nucleotide-binding domain of the HSP70 family; Region: HSP70_NBD; cd10170 272562002025 nucleotide binding site [chemical binding]; other site 272562002026 putative NEF/HSP70 interaction site [polypeptide binding]; other site 272562002027 SBD interface [polypeptide binding]; other site 272562002028 Molecular chaperone [Posttranslational modification, protein turnover, chaperones]; Region: DnaK; COG0443 272562002029 Nucleotide-binding domain of the HSP70 family; Region: HSP70_NBD; cd10170 272562002030 nucleotide binding site [chemical binding]; other site 272562002031 putative NEF/HSP70 interaction site [polypeptide binding]; other site 272562002032 SBD interface [polypeptide binding]; other site 272562002033 Von Willebrand factor type A (vWA) domain was originally found in the blood coagulation protein von Willebrand factor (vWF). Typically, the vWA domain is made up of approximately 200 amino acid residues folded into a classic a/b para-rossmann type of...; Region: vWFA; cd00198 272562002034 metal ion-dependent adhesion site (MIDAS); other site 272562002035 Double zinc ribbon; Region: DZR; pfam12773 272562002036 c-di-GMP phosphodiesterase class II (HD-GYP domain) [Signal transduction mechanisms]; Region: COG2206 272562002037 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 272562002038 Zn2+ binding site [ion binding]; other site 272562002039 Mg2+ binding site [ion binding]; other site 272562002040 M20 Peptidase T specifically cleaves tripeptides; Region: M20_peptT; cd03892 272562002041 peptidase T-like protein; Region: PepT-like; TIGR01883 272562002042 metal binding site [ion binding]; metal-binding site 272562002043 dimer interface [polypeptide binding]; other site 272562002044 Uncharacterized proteins of the AP superfamily [General function prediction only]; Region: COG1524 272562002045 Type I phosphodiesterase / nucleotide pyrophosphatase; Region: Phosphodiest; pfam01663 272562002046 ACT domain proteins similar to the yet uncharacterized Streptococcus pneumoniae ACT domain protein; Region: ACT_1ZPV; cd04872 272562002047 Uncharacterized proteins with similarity to Ribonucleotide reductase and Pyruvate formate lyase; Region: RNR_PFL_like_DUF711; cd08025 272562002048 anaerobic ribonucleoside triphosphate reductase; Provisional; Region: PRK07111 272562002049 ATP cone domain; Region: ATP-cone; pfam03477 272562002050 Class III ribonucleotide reductase; Region: RNR_III; cd01675 272562002051 effector binding site; other site 272562002052 active site 272562002053 Zn binding site [ion binding]; other site 272562002054 glycine loop; other site 272562002055 4Fe-4S single cluster domain; Region: Fer4_12; pfam13353 272562002056 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 272562002057 FeS/SAM binding site; other site 272562002058 Beta-lactamase superfamily domain; Region: Lactamase_B_3; pfam13483 272562002059 CAAX protease self-immunity; Region: Abi; pfam02517 272562002060 phosphoglucosamine mutase; Provisional; Region: glmM; PRK14316 272562002061 GlmM is a bacterial phosphoglucosamine mutase (PNGM) that belongs to the alpha-D-phosphohexomutase superfamily. It is required for the interconversion of glucosamine-6-phosphate and glucosamine-1-phosphate in the biosynthetic pathway of...; Region: GlmM; cd05802 272562002062 active site 272562002063 substrate binding site [chemical binding]; other site 272562002064 metal binding site [ion binding]; metal-binding site 272562002065 Ribonuclease BN family enzyme [Replication, recombination, and repair]; Region: Rbn; COG1295 272562002066 putative iron-only hydrogenase system regulator; Region: hyd_TM1266; TIGR03959 272562002067 4'-phosphopantetheinyl transferase; Provisional; Region: acpS; PRK00070 272562002068 Uncharacterized conserved protein [Function unknown]; Region: COG0062 272562002069 putative carbohydrate kinase; Provisional; Region: PRK10565 272562002070 B.subtilis YXKO protein of unknown function and related proteins. Based on the conservation of the ATP binding site, the substrate binding site and the Mg2+binding site and structural homology this group is a member of the ribokinase-like superfamily; Region: YXKO-related; cd01171 272562002071 putative substrate binding site [chemical binding]; other site 272562002072 putative ATP binding site [chemical binding]; other site 272562002073 Outer membrane lipoprotein-sorting protein [Cell envelope biogenesis, outer membrane]; Region: LolA; COG2834 272562002074 alanine racemase; Reviewed; Region: alr; PRK00053 272562002075 Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzyme Alanine Racemase; Region: PLPDE_III_AR; cd00430 272562002076 active site 272562002077 pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site 272562002078 dimer interface [polypeptide binding]; other site 272562002079 substrate binding site [chemical binding]; other site 272562002080 catalytic residues [active] 272562002081 Predicted transcriptional regulators containing the CopG/Arc/MetJ DNA-binding domain and a metal-binding domain [Transcription]; Region: NikR; COG0864 272562002082 PemK-like protein; Region: PemK; pfam02452 272562002083 Thiamine monophosphate synthase (TMP synthase)/TenI. TMP synthase catalyzes an important step in the thiamine biosynthesis pathway, the substitution of the pyrophosphate of 2-methyl-4-amino-5- hydroxymethylpyrimidine pyrophosphate by 4-methyl-5-; Region: TMP_TenI; cd00564 272562002084 thiamine phosphate binding site [chemical binding]; other site 272562002085 active site 272562002086 pyrophosphate binding site [ion binding]; other site 272562002087 Uncharacterized conserved protein [Function unknown]; Region: COG1284 272562002088 Uncharacterized BCR, YitT family COG1284; Region: DUF161; pfam02588 272562002089 Uncharacterized BCR, YitT family COG1284; Region: DUF161; pfam02588 272562002090 Uncharacterized protein conserved in bacteria (DUF2179); Region: DUF2179; pfam10035 272562002091 Predicted ATPase involved in cell division [Cell division and chromosome partitioning]; Region: FtsE; COG2884 272562002092 ATP-binding cassette domain of the cell division transporter; Region: ABC_FtsE_transporter; cd03292 272562002093 Walker A/P-loop; other site 272562002094 ATP binding site [chemical binding]; other site 272562002095 Q-loop/lid; other site 272562002096 ABC transporter signature motif; other site 272562002097 Walker B; other site 272562002098 D-loop; other site 272562002099 H-loop/switch region; other site 272562002100 Cell division protein [Cell division and chromosome partitioning]; Region: FtsX; COG2177 272562002101 cell division ABC transporter subunit FtsX; Provisional; Region: ftsX; PRK11026 272562002102 Periplasmic protease [Cell envelope biogenesis, outer membrane]; Region: Prc; COG0793 272562002103 C-terminal processing peptidase; serine protease family S41; Region: Peptidase_S41_CPP; cd07560 272562002104 PDZ domain of C-terminal processing-, tail-specific-, and tricorn proteases, which function in posttranslational protein processing, maturation, and disassembly or degradation, in Bacteria, Archaea, and plant chloroplasts. May be responsible for...; Region: PDZ_CTP_protease; cd00988 272562002105 protein binding site [polypeptide binding]; other site 272562002106 Catalytic dyad [active] 272562002107 Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain [Posttranslational modification, protein turnover, chaperones]; Region: DegQ; COG0265 272562002108 PDZ domain of trypsin-like serine proteases, such as DegP/HtrA, which are oligomeric proteins involved in heat-shock response, chaperone function, and apoptosis. May be responsible for substrate recognition and/or binding, as most PDZ domains bind...; Region: PDZ_serine_protease; cd00987 272562002109 undecaprenyl pyrophosphate phosphatase; Reviewed; Region: PRK00281 272562002110 excinuclease ABC subunit B; Provisional; Region: PRK05298 272562002111 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 272562002112 ATP binding site [chemical binding]; other site 272562002113 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 272562002114 putative Mg++ binding site [ion binding]; other site 272562002115 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 272562002116 nucleotide binding region [chemical binding]; other site 272562002117 ATP-binding site [chemical binding]; other site 272562002118 Ultra-violet resistance protein B; Region: UvrB; pfam12344 272562002119 UvrB/uvrC motif; Region: UVR; pfam02151 272562002120 excinuclease ABC subunit A; Reviewed; Region: uvrA; PRK00349 272562002121 ATP-binding cassette domain I of the excision repair protein UvrA; Region: ABC_UvrA_I; cd03270 272562002122 ATP-binding cassette domain I of the excision repair protein UvrA; Region: ABC_UvrA_I; cd03270 272562002123 ATP-binding cassette domain II of the excision repair protein UvrA; Region: ABC_UvrA_II; cd03271 272562002124 FOG: FHA domain [Signal transduction mechanisms]; Region: COG1716 272562002125 Forkhead associated domain (FHA); found in eukaryotic and prokaryotic proteins. Putative nuclear signalling domain. FHA domains may bind phosphothreonine, phosphoserine and sometimes phosphotyrosine. In eukaryotes, many FHA domain-containing proteins...; Region: FHA; cd00060 272562002126 phosphopeptide binding site; other site 272562002127 Bacterial cell division membrane protein [Cell division and chromosome partitioning]; Region: FtsW; COG0772 272562002128 Cell division protein FtsI/penicillin-binding protein 2 [Cell envelope biogenesis, outer membrane]; Region: FtsI; COG0768 272562002129 Penicillin-binding Protein dimerization domain; Region: PBP_dimer; pfam03717 272562002130 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; pfam00905 272562002131 Predicted membrane-bound metal-dependent hydrolase (DUF457); Region: DUF457; pfam04307 272562002132 excinuclease ABC subunit C; Validated; Region: uvrC; PRK00558 272562002133 Catalytic GIY-YIG domain of nucleotide excision repair endonucleases UvrC, Cho, and similar proteins; Region: GIY-YIG_UvrC_Cho; cd10434 272562002134 GIY-YIG motif/motif A; other site 272562002135 active site 272562002136 catalytic site [active] 272562002137 putative DNA binding site [nucleotide binding]; other site 272562002138 metal binding site [ion binding]; metal-binding site 272562002139 UvrB/uvrC motif; Region: UVR; pfam02151 272562002140 UvrC Helix-hairpin-helix N-terminal; Region: UvrC_HhH_N; pfam08459 272562002141 Helix-hairpin-helix motif; Region: HHH_2; pfam12826 272562002142 putative hydrolase; Validated; Region: PRK09248 272562002143 Polymerase and Histidinol Phosphatase domain of Ycdx like; Region: PHP_HisPPase_Ycdx_like; cd07437 272562002144 active site 272562002145 UDP-N-acetylenolpyruvoylglucosamine reductase; Provisional; Region: murB; PRK13905 272562002146 FAD binding domain; Region: FAD_binding_4; pfam01565 272562002147 UDP-N-acetylenolpyruvoylglucosamine reductase, C-terminal domain; Region: MurB_C; pfam02873 272562002148 glmZ(sRNA)-inactivating NTPase; Provisional; Region: PRK05416 272562002149 family of mostly uncharacterized proteins similar to B.subtilis YvcK; Region: YvcK_like; cd07187 272562002150 phosphate binding site [ion binding]; other site 272562002151 putative substrate binding pocket [chemical binding]; other site 272562002152 dimer interface [polypeptide binding]; other site 272562002153 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG1481 272562002154 WhiA N-terminal LAGLIDADG-like domain; Region: WhiA_N; pfam10298 272562002155 WhiA LAGLIDADG-like domain; Region: LAGLIDADG_WhiA; pfam14527 272562002156 WhiA C-terminal HTH domain; Region: HTH_WhiA; pfam02650 272562002157 Predicted transcriptional regulator containing CBS domains [Transcription]; Region: COG4109 272562002158 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cl17414 272562002159 DNA-binding site [nucleotide binding]; DNA binding site 272562002160 DRTGG domain; Region: DRTGG; pfam07085 272562002161 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains associated with a DRTGG domain upstream. The function of the DRTGG domain, named after its conserved residues, is unknown. CBS is a small domain originally...; Region: CBS_pair_DRTGG_assoc; cd04596 272562002162 The hotdog fold was initially identified in the E. coli FabA (beta-hydroxydecanoyl-acyl carrier protein (ACP)-dehydratase) structure and subsequently in 4HBT (4-hydroxybenzoyl-CoA thioesterase) from Pseudomonas. A number of other seemingly unrelated...; Region: hot_dog; cd03440 272562002163 active site 2 [active] 272562002164 Stress responsive A/B Barrel Domain; Region: Dabb; smart00886 272562002165 DNA polymerase III DnaE; Reviewed; Region: dnaE; PRK06826 272562002166 Polymerase and Histidinol Phosphatase domain of alpha-subunit of bacterial polymerase III DnaE3; Region: PHP_PolIIIA_DnaE3; cd12113 272562002167 active site 272562002168 PHP Thumb interface [polypeptide binding]; other site 272562002169 metal binding site [ion binding]; metal-binding site 272562002170 Bacterial DNA polymerase III alpha subunit; Region: DNA_pol3_alpha; pfam07733 272562002171 Helix-hairpin-helix motif; Region: HHH_6; pfam14579 272562002172 DnaE_OBF: A subfamily of OB folds corresponding to the C-terminal OB-fold nucleic acid binding domain of Thermus aquaticus and Escherichia coli type C replicative DNA polymerase III alpha subunit (DnaE). The DNA polymerase holoenzyme of E. coli contains...; Region: DnaE_OBF; cd04485 272562002173 generic binding surface II; other site 272562002174 generic binding surface I; other site 272562002175 6-phosphofructokinase; Provisional; Region: PRK03202 272562002176 active site 272562002177 ADP/pyrophosphate binding site [chemical binding]; other site 272562002178 dimerization interface [polypeptide binding]; other site 272562002179 allosteric effector site; other site 272562002180 fructose-1,6-bisphosphate binding site; other site 272562002181 Pyruvate kinase [Carbohydrate transport and metabolism]; Region: PykF; COG0469 272562002182 Pyruvate kinase (PK): Large allosteric enzyme that regulates glycolysis through binding of the substrate, phosphoenolpyruvate, and one or more allosteric effectors. Like other allosteric enzymes, PK has a high substrate affinity R state and a low...; Region: Pyruvate_Kinase; cd00288 272562002183 domain interfaces; other site 272562002184 active site 272562002185 dihydroorotase; Validated; Region: pyrC; PRK09357 272562002186 Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281 272562002187 Dihydroorotase (DHOase), subgroup IIa; DHOases catalyze the reversible interconversion of carbamoyl aspartate to dihydroorotate, a key reaction in pyrimidine biosynthesis. This subgroup also contains proteins that lack the active site, like unc-33, a C; Region: DHOase_IIa; cd01317 272562002188 active site 272562002189 Domain of Unknown Function (DUF1540); Region: DUF1540; pfam07561 272562002190 Domain of Unknown Function (DUF1540); Region: DUF1540; pfam07561 272562002191 Predicted hydrolases of the HAD superfamily [General function prediction only]; Region: Cof; COG0561 272562002192 haloacid dehalogenase-like hydrolase; Region: HAD; cl19137 272562002193 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 272562002194 active site 272562002195 motif I; other site 272562002196 motif II; other site 272562002197 TRAM domain; Region: TRAM; cl01282 272562002198 SAM-dependent methyltransferases related to tRNA (uracil-5-)-methyltransferase [Translation, ribosomal structure and biogenesis]; Region: TrmA; COG2265 272562002199 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 272562002200 S-adenosylmethionine binding site [chemical binding]; other site 272562002201 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 272562002202 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 272562002203 active site 272562002204 phosphorylation site [posttranslational modification] 272562002205 intermolecular recognition site; other site 272562002206 dimerization interface [polypeptide binding]; other site 272562002207 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 272562002208 DNA binding site [nucleotide binding] 272562002209 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 272562002210 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 272562002211 dimer interface [polypeptide binding]; other site 272562002212 phosphorylation site [posttranslational modification] 272562002213 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 272562002214 ATP binding site [chemical binding]; other site 272562002215 Mg2+ binding site [ion binding]; other site 272562002216 G-X-G motif; other site 272562002217 ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136 272562002218 ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255 272562002219 Walker A/P-loop; other site 272562002220 ATP binding site [chemical binding]; other site 272562002221 Q-loop/lid; other site 272562002222 ABC transporter signature motif; other site 272562002223 Walker B; other site 272562002224 D-loop; other site 272562002225 H-loop/switch region; other site 272562002226 MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704 272562002227 ABC-type antimicrobial peptide transport system, permease component [Defense mechanisms]; Region: SalY; COG0577 272562002228 FtsX-like permease family; Region: FtsX; pfam02687 272562002229 ABC-type antimicrobial peptide transport system, permease component [Defense mechanisms]; Region: SalY; COG0577 272562002230 FtsX-like permease family; Region: FtsX; pfam02687 272562002231 ATPase components of ABC transporters with duplicated ATPase domains [General function prediction only]; Region: Uup; COG0488 272562002232 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 272562002233 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 272562002234 Domain of unknown function (DUF303); Region: DUF303; pfam03629 272562002235 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cl17220 272562002236 Helix-turn-helix domain, rpiR family; Region: HTH_6; pfam01418 272562002237 Transcriptional regulators [Transcription]; Region: RpiR; COG1737 272562002238 RpiR-like protein. RpiR contains a SIS (Sugar ISomerase) domain, which is found in many phosphosugar isomerases and phosphosugar binding proteins. In E. coli, rpiR negatively regulates the expression of rpiB gene. Both rpiB and rpiA are ribose phosphate...; Region: SIS_RpiR; cd05013 272562002239 putative active site [active] 272562002240 PTS system, alpha-glucoside-specific IIBC component; Region: PTS-IIBC-alpha; TIGR02005 272562002241 Phosphotransferase system IIC components, glucose/maltose/N-acetylglucosamine-specific [Carbohydrate transport and metabolism]; Region: PtsG; COG1263 272562002242 PTS_IIB, PTS system, glucose/sucrose specific IIB subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIB_glc; cd00212 272562002243 active site turn [active] 272562002244 phosphorylation site [posttranslational modification] 272562002245 Alpha-galactosidases/6-phospho-beta-glucosidases, family 4 of glycosyl hydrolases [Carbohydrate transport and metabolism]; Region: CelF; COG1486 272562002246 Glycoside Hydrolases Family 4; GlvA- and pagL-like glycosidases; Region: GH4_GlvA_pagL_like; cd05298 272562002247 NAD binding site [chemical binding]; other site 272562002248 sugar binding site [chemical binding]; other site 272562002249 divalent metal binding site [ion binding]; other site 272562002250 putative tetramer (dimer of dimers) interface [polypeptide binding]; other site 272562002251 dimer interface [polypeptide binding]; other site 272562002252 phosphoenolpyruvate synthase; Validated; Region: PRK06241 272562002253 Pyruvate phosphate dikinase, PEP/pyruvate binding domain; Region: PPDK_N; pfam01326 272562002254 PEP-utilizing enzyme, mobile domain; Region: PEP-utilizers; pfam00391 272562002255 Metal-dependent hydrolases of the beta-lactamase superfamily II [General function prediction only]; Region: COG1237 272562002256 Short-chain dehydrogenase involved in D-alanine esterification of lipoteichoic acid and wall teichoic acid (D-alanine transfer protein) [Cell envelope biogenesis, outer membrane]; Region: DltE; COG3967 272562002257 classical (c) SDR, subgroup 2; Region: SDR_c2; cd05370 272562002258 putative NAD(P) binding site [chemical binding]; other site 272562002259 active site 272562002260 Endoglucanase E-like members of the SGNH hydrolase family; Endoglucanase E catalyzes the endohydrolysis of 1,4-beta-glucosidic linkages in cellulose, lichenin and cereal beta-D-glucans; Region: Endoglucanase_E_like; cd01831 272562002261 active site 272562002262 catalytic triad [active] 272562002263 oxyanion hole [active] 272562002264 Beta-mannanase [Carbohydrate transport and metabolism]; Region: ManB; COG4124 272562002265 Bacterial surface proteins containing Ig-like domains [Cell motility and secretion]; Region: COG5492 272562002266 Clostridial hydrophobic, with a conserved W residue, domain; Region: ChW; smart00728 272562002267 Clostridial hydrophobic, with a conserved W residue, domain; Region: ChW; smart00728 272562002268 Clostridial hydrophobic, with a conserved W residue, domain; Region: ChW; smart00728 272562002269 Beta-mannanase [Carbohydrate transport and metabolism]; Region: ManB; COG4124 272562002270 Bacterial surface proteins containing Ig-like domains [Cell motility and secretion]; Region: COG5492 272562002271 Clostridial hydrophobic, with a conserved W residue, domain; Region: ChW; smart00728 272562002272 Clostridial hydrophobic, with a conserved W residue, domain; Region: ChW; smart00728 272562002273 Clostridial hydrophobic, with a conserved W residue, domain; Region: ChW; smart00728 272562002274 Beta-mannanase [Carbohydrate transport and metabolism]; Region: ManB; COG4124 272562002275 Bacterial surface proteins containing Ig-like domains [Cell motility and secretion]; Region: COG5492 272562002276 Clostridial hydrophobic, with a conserved W residue, domain; Region: ChW; smart00728 272562002277 Clostridial hydrophobic, with a conserved W residue, domain; Region: ChW; smart00728 272562002278 Clostridial hydrophobic, with a conserved W residue, domain; Region: ChW; smart00728 272562002279 Methyltransferase domain; Region: Methyltransf_31; pfam13847 272562002280 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 272562002281 S-adenosylmethionine binding site [chemical binding]; other site 272562002282 Endo-N-acetylmuramidases (muramidases) are lysozymes (also referred to as peptidoglycan hydrolases) that degrade bacterial cell walls by catalyzing the hydrolysis of 1,4-beta-linkages between N-acetylmuramic acid and N-acetyl-D-glucosamine residues; Region: GH25_muramidase; cl10448 272562002283 ligand binding domain of Tar- and Tsr-related chemoreceptors; Region: Tar_Tsr_LBD; cl00144 272562002284 Methyl-accepting chemotaxis protein [Cell motility and secretion / Signal transduction mechanisms]; Region: Tar; COG0840 272562002285 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 272562002286 dimerization interface [polypeptide binding]; other site 272562002287 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cl19050 272562002288 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cl19050 272562002289 dimer interface [polypeptide binding]; other site 272562002290 putative CheW interface [polypeptide binding]; other site 272562002291 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 272562002292 dimerization interface [polypeptide binding]; other site 272562002293 Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer); Region: MA; smart00283 272562002294 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cl19050 272562002295 dimer interface [polypeptide binding]; other site 272562002296 putative CheW interface [polypeptide binding]; other site 272562002297 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4443 272562002298 Protein of unknown function (DUF4064); Region: DUF4064; pfam13273 272562002299 This conserved domain belongs to a superfamily including the bleomycin resistance protein, glyoxalase I, and type I ring-cleaving dioxygenases; Region: Glo_EDI_BRP_like_23; cd09011 272562002300 Predicted Zn peptidase [Amino acid transport and metabolism]; Region: COG2856 272562002301 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 272562002302 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 272562002303 non-specific DNA binding site [nucleotide binding]; other site 272562002304 salt bridge; other site 272562002305 sequence-specific DNA binding site [nucleotide binding]; other site 272562002306 RNA polymerase sigma factor, sigma-70 family; Region: sigma70-ECF; TIGR02937 272562002307 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cl17257 272562002308 DNA binding residues [nucleotide binding] 272562002309 Bacterial surface proteins containing Ig-like domains [Cell motility and secretion]; Region: COG5492 272562002310 Bacterial Ig-like domain (group 2); Region: Big_2; pfam02368 272562002311 Bacterial surface proteins containing Ig-like domains [Cell motility and secretion]; Region: COG5492 272562002312 Bacterial Ig-like domain (group 2); Region: Big_2; pfam02368 272562002313 Haemolysin XhlA; Region: XhlA; pfam10779 272562002314 Lyc muramidase is an autolytic lysozyme (autolysin) from Clostridium acetobutylicum encoded by the lyc gene. Lyc has a glycosyl hydrolase family 25 (GH25) catalytic domain. Endo-N-acetylmuramidases are lysozymes (also referred to as peptidoglycan...; Region: GH25_Lyc-like; cd06525 272562002315 Glycosyl hydrolases family 25; Region: Glyco_hydro_25; pfam01183 272562002316 active site 272562002317 Putative peptidoglycan-binding domain-containing protein [Cell envelope biogenesis, outer membrane]; Region: COG3409 272562002318 Putative peptidoglycan binding domain; Region: PG_binding_1; pfam01471 272562002319 Putative peptidoglycan binding domain; Region: PG_binding_1; pfam01471 272562002320 Predicted membrane protein [Function unknown]; Region: COG2717 272562002321 Uncharacterized conserved protein [Function unknown]; Region: COG2013 272562002322 Zn-dependent protease with chaperone function [Posttranslational modification, protein turnover, chaperones]; Region: HtpX; COG0501 272562002323 Transcriptional regulators [Transcription]; Region: MarR; COG1846 272562002324 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 272562002325 putative DNA binding site [nucleotide binding]; other site 272562002326 putative Zn2+ binding site [ion binding]; other site 272562002327 Arabinose efflux permease [Carbohydrate transport and metabolism]; Region: AraJ; COG2814 272562002328 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 272562002329 putative substrate translocation pore; other site 272562002330 Carbohydrate binding domain; Region: CBM_4_9; pfam02018 272562002331 N-terminal Early set domain associated with the catalytic domain of cellulase; Region: E_set_Cellulase_N; cd02850 272562002332 Glycosyl hydrolase family 9; Region: Glyco_hydro_9; pfam00759 272562002333 Dockerin type I repeat; Region: Dockerin_1; pfam00404 272562002334 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 272562002335 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 272562002336 active site 272562002337 phosphorylation site [posttranslational modification] 272562002338 intermolecular recognition site; other site 272562002339 dimerization interface [polypeptide binding]; other site 272562002340 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 272562002341 DNA binding site [nucleotide binding] 272562002342 heavy metal sensor kinase; Region: cztS_silS_copS; TIGR01386 272562002343 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 272562002344 dimerization interface [polypeptide binding]; other site 272562002345 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 272562002346 dimer interface [polypeptide binding]; other site 272562002347 phosphorylation site [posttranslational modification] 272562002348 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 272562002349 ATP binding site [chemical binding]; other site 272562002350 Mg2+ binding site [ion binding]; other site 272562002351 G-X-G motif; other site 272562002352 Malate/L-lactate dehydrogenases [Energy production and conversion]; Region: COG2055 272562002353 Methyltransferase domain; Region: Methyltransf_31; pfam13847 272562002354 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 272562002355 S-adenosylmethionine binding site [chemical binding]; other site 272562002356 aspartate-semialdehyde dehydrogenase; Reviewed; Region: PRK08664 272562002357 Semialdehyde dehydrogenase, NAD binding domain; Region: Semialdhyde_dh; smart00859 272562002358 Semialdehyde dehydrogenase, dimerization domain; Region: Semialdhyde_dhC; pfam02774 272562002359 CAT RNA binding domain; Region: CAT_RBD; smart01061 272562002360 transcriptional antiterminator BglG; Provisional; Region: PRK09772 272562002361 PRD domain; Region: PRD; pfam00874 272562002362 PRD domain; Region: PRD; pfam00874 272562002363 Phosphotransferase system IIC components, glucose/maltose/N-acetylglucosamine-specific [Carbohydrate transport and metabolism]; Region: PtsG; COG1263 272562002364 PTS system N-acetyl glucosamine specific transporter subunits IIABC; Provisional; Region: PRK10255 272562002365 PTS_IIB, PTS system, glucose/sucrose specific IIB subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIB_glc; cd00212 272562002366 active site turn [active] 272562002367 phosphorylation site [posttranslational modification] 272562002368 Phosphotransferase system IIA components [Carbohydrate transport and metabolism]; Region: NagE; COG2190 272562002369 HPr interaction site; other site 272562002370 glycerol kinase (GK) interaction site [polypeptide binding]; other site 272562002371 active site 272562002372 phosphorylation site [posttranslational modification] 272562002373 Predicted transcriptional regulators [Transcription]; Region: COG1695 272562002374 putative Zn2+ binding site [ion binding]; other site 272562002375 putative DNA binding site [nucleotide binding]; other site 272562002376 Predicted membrane protein [Function unknown]; Region: COG4709 272562002377 Domain of unknown function (DUF4098); Region: DUF4098; cl19992 272562002378 Uncharacterized conserved protein [Function unknown]; Region: COG3595 272562002379 Domain of unknown function (DUF4098); Region: DUF4098; pfam13345 272562002380 Domain of unknown function (DUF4098); Region: DUF4098; pfam13345 272562002381 Beta-xylosidase [Carbohydrate transport and metabolism]; Region: XynB; COG3507 272562002382 Glycosyl hydrolase family 43; Region: GH43_ABN_1; cd08998 272562002383 substrate binding site [chemical binding]; other site 272562002384 active site 272562002385 Ricin-type beta-trefoil; Carbohydrate-binding domain formed from presumed gene triplication. The domain is found in a variety of molecules serving diverse functions such as enzymatic activity, inhibitory toxicity and signal transduction. Highly specific...; Region: RICIN; cd00161 272562002386 putative sugar binding sites [chemical binding]; other site 272562002387 Q-X-W motif; other site 272562002388 B12-dependent methionine synthase; Provisional; Region: metH; PRK09490 272562002389 Methionine synthase I (cobalamin-dependent), methyltransferase domain [Amino acid transport and metabolism]; Region: MetH; COG0646 272562002390 MeTr subgroup of pterin binding enzymes. This family includes cobalamin-dependent methyltransferases such as methyltetrahydrofolate, corrinoid iron-sulfur protein methyltransferase (MeTr) and methionine synthase (MetH). Cobalamin-dependent...; Region: MeTr; cd00740 272562002391 substrate binding pocket [chemical binding]; other site 272562002392 B12 binding domain of methionine synthase. This domain binds methylcobalamin, which it uses as an intermediate methyl carrier from methyltetrahydrofolate (CH3H4folate) to homocysteine (Hcy); Region: methionine_synthase_B12_BD; cd02069 272562002393 B12 binding site [chemical binding]; other site 272562002394 cobalt ligand [ion binding]; other site 272562002395 Vitamin B12 dependent methionine synthase, activation domain; Region: Met_synt_B12; pfam02965 272562002396 Putative Ser protein kinase [Signal transduction mechanisms]; Region: PrkA; COG2766 272562002397 PrkA AAA domain; Region: AAA_PrkA; pfam08298 272562002398 PrkA serine protein kinase C-terminal domain; Region: PrkA; pfam06798 272562002399 sporulation protein YhbH; Region: spore_yhbH; TIGR02877 272562002400 Von Willebrand factor type A (vWA) domain was originally found in the blood coagulation protein von Willebrand factor (vWF). Typically, the vWA domain is made up of approximately 200 amino acid residues folded into a classic a/b para-rossmann type of...; Region: vWFA; cd00198 272562002401 metal ion-dependent adhesion site (MIDAS); other site 272562002402 Uncharacterized conserved protein [Function unknown]; Region: SpoVR; COG2719 272562002403 cobalamin biosynthesis protein; Provisional; Region: cobD; PRK01209 272562002404 Cobalamin biosynthesis protein CbiK, Co2+ chelatase [Coenzyme metabolism]; Region: CbiK; COG4822 272562002405 Anaerobic cobalamin biosynthetic cobalt chelatase (CbiK), N-terminal domain. CbiK is part of the cobalt-early path for cobalamin biosynthesis. It catalyzes the insertion of cobalt into the oxidized form of precorrin-2, factor II (sirohydrochlorin), the...; Region: CbiK_N; cd03412 272562002406 active site 272562002407 C-terminal domain interface [polypeptide binding]; other site 272562002408 Anaerobic cobalamin biosynthetic cobalt chelatase (CbiK), C-terminal domain. CbiK is part of the cobalt-early path for cobalamin biosynthesis. It catalyzes the insertion of cobalt into the oxidized form of precorrin-2, factor II (sirohydrochlorin), the...; Region: CbiK_C; cd03413 272562002409 active site 272562002410 N-terminal domain interface [polypeptide binding]; other site 272562002411 Precorrin-6Y methyltransferase, the cobalamin biosynthesis enzyme CbiE; Region: Precorrin-6Y-methylase; cd11644 272562002412 active site 272562002413 putative homodimer interface [polypeptide binding]; other site 272562002414 SAM binding site [chemical binding]; other site 272562002415 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 272562002416 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 272562002417 active site 272562002418 phosphorylation site [posttranslational modification] 272562002419 intermolecular recognition site; other site 272562002420 dimerization interface [polypeptide binding]; other site 272562002421 Chemotaxis phosphatase CheX; Region: CheX; pfam13690 272562002422 Predicted inhibitor of MCP methylation, homolog of CheC [Cell motility and secretion]; Region: COG1406 272562002423 Chemotaxis phosphatase CheX; Region: CheX; pfam13690 272562002424 flavodoxin; Provisional; Region: PRK05568 272562002425 Uncharacterized flavoproteins [Energy production and conversion]; Region: FpaA; COG0426 272562002426 Protein of unknown function (DUF3793); Region: DUF3793; pfam12672 272562002427 Biotin-(acetyl-CoA carboxylase) ligase [Coenzyme metabolism]; Region: BirA; COG0340 272562002428 Biotin/lipoate A/B protein ligase family; Region: BPL_LplA_LipB; cl14057 272562002429 riboflavin biosynthesis protein RibD; Region: eubact_ribD; TIGR00326 272562002430 Riboflavin-specific deaminase. Riboflavin biosynthesis protein RibD (Diaminohydroxyphosphoribosylaminopyrimidine deaminase) catalyzes the deamination of 2,5-diamino-6-ribosylamino-4(3H)-pyrimidinone 5'-phosphate, which is an intermediate step in the...; Region: Riboflavin_deaminase-reductase; cd01284 272562002431 catalytic motif [active] 272562002432 Zn binding site [ion binding]; other site 272562002433 Pyrimidine reductase, riboflavin biosynthesis [Coenzyme metabolism]; Region: RibD; COG1985 272562002434 riboflavin synthase subunit alpha; Provisional; Region: PRK09289 272562002435 Lumazine binding domain; Region: Lum_binding; pfam00677 272562002436 Lumazine binding domain; Region: Lum_binding; pfam00677 272562002437 bifunctional 3,4-dihydroxy-2-butanone 4-phosphate synthase/GTP cyclohydrolase II protein; Provisional; Region: PRK09311 272562002438 3,4-dihydroxy-2-butanone 4-phosphate synthase [Coenzyme metabolism]; Region: RibB; COG0108 272562002439 GTP cyclohydrolase II (RibA). GTP cyclohydrolase II catalyzes the conversion of GTP to 2,5-diamino-6-ribosylamino-4(3H)-pyrimidinone 5' phosphate, formate, pyrophosphate (APy), and GMP in the biosynthetic pathway of riboflavin. Riboflavin is the...; Region: GTP_cyclohydro2; cd00641 272562002440 dimerization interface [polypeptide binding]; other site 272562002441 active site 272562002442 lumazine synthase (6,7-dimethyl-8-ribityllumazine synthase, LS), catalyzes the penultimate step in the biosynthesis of riboflavin (vitamin B2); type-I; Region: Lumazine_synthase-I; cd09209 272562002443 homopentamer interface [polypeptide binding]; other site 272562002444 active site 272562002445 PdxS is a subunit of the pyridoxal 5'-phosphate (PLP) synthase, an important enzyme in deoxyxylulose 5-phosphate (DXP)-independent pathway for de novo biosynthesis of PLP, present in some eubacteria, in archaea, fungi, plants, plasmodia, and some...; Region: pdxS; cd04727 272562002446 active site 272562002447 multimer interface [polypeptide binding]; other site 272562002448 Glutamine Amidotransferase (GATase_I) involved in pyridoxine biosynthesis; Region: GATase1_PB; cd01749 272562002449 predicted active site [active] 272562002450 catalytic triad [active] 272562002451 Bacillus/Clostridium GerA spore germination protein; Region: GerA; pfam03323 272562002452 Spore germination protein; Region: Spore_permease; pfam03845 272562002453 Spore germination B3/ GerAC like, C-terminal; Region: Spore_GerAC; cl19906 272562002454 Predicted transcriptional regulators [Transcription]; Region: COG1725 272562002455 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 272562002456 DNA-binding site [nucleotide binding]; DNA binding site 272562002457 Predicted membrane protein [General function prediction only]; Region: COG4194 272562002458 WG containing repeat; Region: WG_beta_rep; pfam14903 272562002459 WG containing repeat; Region: WG_beta_rep; pfam14903 272562002460 WG containing repeat; Region: WG_beta_rep; pfam14903 272562002461 FtsH Extracellular; Region: FtsH_ext; pfam06480 272562002462 ATP-dependent metalloprotease FtsH; Region: FtsH_fam; TIGR01241 272562002463 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 272562002464 Walker A motif; other site 272562002465 ATP binding site [chemical binding]; other site 272562002466 Walker B motif; other site 272562002467 arginine finger; other site 272562002468 Peptidase family M41; Region: Peptidase_M41; pfam01434 272562002469 Superfamily I DNA and RNA helicases [General function prediction only]; Region: COG3973 272562002470 Part of AAA domain; Region: AAA_19; pfam13245 272562002471 UvrD-like helicase C-terminal domain; Region: UvrD_C_2; cl19402 272562002472 Acyl carrier protein phosphodiesterase [Lipid metabolism]; Region: AcpD; COG1182 272562002473 PAP2_like proteins, a super-family of histidine phosphatases and vanadium haloperoxidases, includes type 2 phosphatidic acid phosphatase or lipid phosphate phosphatase (LPP), Glucose-6-phosphatase, Phosphatidylglycerophosphatase B and bacterial acid...; Region: PAP2_like; cl00474 272562002474 Membrane-associated phospholipid phosphatase [Lipid metabolism]; Region: PgpB; COG0671 272562002475 active site 272562002476 Predicted Co/Zn/Cd cation transporters [Inorganic ion transport and metabolism]; Region: MMT1; COG0053 272562002477 M18 Peptidase Aspartyl aminopeptidase; Region: M18_DAP; cd05658 272562002478 active site 272562002479 metal binding site [ion binding]; metal-binding site 272562002480 diaminopimelate decarboxylase; Region: lysA; TIGR01048 272562002481 Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzyme Diaminopimelate Decarboxylase; Region: PLPDE_III_DapDC; cd06828 272562002482 active site 272562002483 pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site 272562002484 substrate binding site [chemical binding]; other site 272562002485 catalytic residues [active] 272562002486 dimer interface [polypeptide binding]; other site 272562002487 Putative glucoamylase; Region: Glycoamylase; pfam10091 272562002488 Second GH94N domain of cyclic beta 1-2 glucan synthetase and similar domains; Region: GH94N_ChvB_NdvB_2_like; cd11753 272562002489 Cellobiose phosphorylase [Carbohydrate transport and metabolism]; Region: COG3459 272562002490 First GH94N domain of cyclic beta 1-2 glucan synthetase and similar domains; Region: GH94N_ChvB_NdvB_1_like; cd11756 272562002491 Protein of unknown function, DUF608; Region: DUF608; pfam04685 272562002492 Putative effector of murein hydrolase [Cell envelope biogenesis, outer membrane]; Region: LrgB; COG1346 272562002493 Putative effector of murein hydrolase LrgA [General function prediction only]; Region: COG1380 272562002494 Spore coat protein [Cell envelope biogenesis, outer membrane]; Region: COG5577 272562002495 Spore coat protein [Cell envelope biogenesis, outer membrane]; Region: COG5577 272562002496 HEAT repeats; Region: HEAT_2; pfam13646 272562002497 ABC-type nitrate/sulfonate/bicarbonate transport system, permease component [Inorganic ion transport and metabolism]; Region: TauC; COG0600 272562002498 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 272562002499 dimer interface [polypeptide binding]; other site 272562002500 conserved gate region; other site 272562002501 putative PBP binding loops; other site 272562002502 ABC-ATPase subunit interface; other site 272562002503 ABC-type nitrate/sulfonate/bicarbonate transport system, ATPase component [Inorganic ion transport and metabolism]; Region: TauB; COG1116 272562002504 ATP-binding cassette domain of the nitrate and sulfonate transporters; Region: ABC_NrtD_SsuB_transporters; cd03293 272562002505 Walker A/P-loop; other site 272562002506 ATP binding site [chemical binding]; other site 272562002507 Q-loop/lid; other site 272562002508 ABC transporter signature motif; other site 272562002509 Walker B; other site 272562002510 D-loop; other site 272562002511 H-loop/switch region; other site 272562002512 ABC-type nitrate/sulfonate/bicarbonate transport systems, periplasmic components [Inorganic ion transport and metabolism]; Region: TauA; COG0715 272562002513 ABC transporter, phosphonate, periplasmic substrate-binding protein; Region: Phosphonate-bd; cl19131 272562002514 Exopolyphosphatase [Nucleotide transport and metabolism / Inorganic ion transport and metabolism]; Region: GppA; COG0248 272562002515 exopolyphosphatase; Region: exo_poly_only; TIGR03706 272562002516 Polyphosphate kinase [Inorganic ion transport and metabolism]; Region: Ppk; COG0855 272562002517 Polyphosphate kinase N-terminal domain; Region: PP_kinase_N; pfam13089 272562002518 Polyphosphate kinase middle domain; Region: PP_kinase; pfam02503 272562002519 Catalytic C-terminal domain, first repeat, of Pseudomonas aeruginosa polyphosphate kinase 1 and similar proteins; Region: PLDc_PaPPK1_C1_like; cd09165 272562002520 putative domain interface [polypeptide binding]; other site 272562002521 putative active site [active] 272562002522 catalytic site [active] 272562002523 Catalytic C-terminal domain, second repeat, of Pseudomonas aeruginosa polyphosphate kinase 1 and similar proteins; Region: PLDc_PaPPK1_C2_like; cd09168 272562002524 putative domain interface [polypeptide binding]; other site 272562002525 putative active site [active] 272562002526 catalytic site [active] 272562002527 Predicted protease [Posttranslational modification, protein turnover, chaperones]; Region: COG4934 272562002528 Activation domain of S53 peptidases; Region: Pro-peptidase_S53; cd11377 272562002529 peptidase domain interface [polypeptide binding]; other site 272562002530 Peptidase domain in the S53 family; Region: Peptidases_S53; cd04056 272562002531 active site 272562002532 catalytic triad [active] 272562002533 calcium binding site [ion binding]; other site 272562002534 tryptophanyl-tRNA synthetase; Reviewed; Region: PRK00927 272562002535 catalytic core domain of tryptophanyl-tRNA synthetase; Region: TrpRS_core; cd00806 272562002536 active site 272562002537 HIGH motif; other site 272562002538 dimer interface [polypeptide binding]; other site 272562002539 KMSKS motif; other site 272562002540 Transcriptional regulators [Transcription]; Region: MarR; COG1846 272562002541 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cl17220 272562002542 Mn2+ and Fe2+ transporters of the NRAMP family [Inorganic ion transport and metabolism]; Region: MntH; COG1914 272562002543 Natural resistance-associated macrophage protein; Region: Nramp; pfam01566 272562002544 sugar phosphate phosphatase; Provisional; Region: PRK10513 272562002545 haloacid dehalogenase-like hydrolase; Region: HAD; cl19137 272562002546 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 272562002547 active site 272562002548 motif I; other site 272562002549 motif II; other site 272562002550 haloacid dehalogenase-like hydrolase; Region: HAD; cl19137 272562002551 Peptide chain release factor RF-3 [Translation, ribosomal structure and biogenesis]; Region: PrfC; COG4108 272562002552 Release Factor 3 (RF3) protein involved in the terminal step of translocation in bacteria; Region: RF3; cd04169 272562002553 G1 box; other site 272562002554 putative GEF interaction site [polypeptide binding]; other site 272562002555 GTP/Mg2+ binding site [chemical binding]; other site 272562002556 Switch I region; other site 272562002557 G2 box; other site 272562002558 G3 box; other site 272562002559 Switch II region; other site 272562002560 G4 box; other site 272562002561 G5 box; other site 272562002562 RF3_II: this subfamily represents the domain II of bacterial Release Factor 3 (RF3). Termination of protein synthesis by the ribosome requires two release factor (RF) classes. The class II RF3 is a GTPase that removes class I RFs (RF1 or RF2) from the...; Region: RF3_II; cd03689 272562002563 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 272562002564 metal binding site [ion binding]; metal-binding site 272562002565 active site 272562002566 I-site; other site 272562002567 EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2). The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948 272562002568 Predicted phosphatase/phosphohexomutase [General function prediction only]; Region: COG0637 272562002569 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 272562002570 active site 272562002571 motif I; other site 272562002572 motif II; other site 272562002573 PAP2_like proteins, Aur1_like subfamily. Yeast Aur1p or Ipc1p is necessary for the addition of inositol phosphate to ceramide, an essential step in yeast sphingolipid synthesis, and is the target of several antifungal compounds such as aureobasidin; Region: PAP2_Aur1_like; cd03386 272562002574 active site 272562002575 Membrane-associated phospholipid phosphatase [Lipid metabolism]; Region: PgpB; COG0671 272562002576 Predicted membrane protein [Function unknown]; Region: COG4720 272562002577 Probable zinc-binding domain; Region: zf-trcl; pfam13451 272562002578 GAF domain; Region: GAF_3; pfam13492 272562002579 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 272562002580 metal binding site [ion binding]; metal-binding site 272562002581 active site 272562002582 I-site; other site 272562002583 tyrosyl-tRNA synthetase; Validated; Region: PRK05912 272562002584 catalytic core domain of tyrosinyl-tRNA synthetase; Region: TyrRS_core; cd00805 272562002585 active site 272562002586 HIGH motif; other site 272562002587 dimer interface [polypeptide binding]; other site 272562002588 KMSKS motif; other site 272562002589 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 272562002590 RNA binding surface [nucleotide binding]; other site 272562002591 transferase, transferring glycosyl groups; Region: PLN02939 272562002592 Uncharacterized homolog of the cytoplasmic domain of flagellar protein FhlB [Function unknown]; Region: COG2257 272562002593 Predicted phosphohydrolase [General function prediction only]; Region: COG1768 272562002594 Predicted phosphohydrolases [General function prediction only]; Region: Icc; COG1409 272562002595 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG1655 272562002596 Uncharacterized protein conserved in bacteria (DUF2225); Region: DUF2225; pfam09986 272562002597 Nucleotidyltransferase (NT) domain of RelA- and SpoT-like ppGpp synthetases and hydrolases; Region: NT_Rel-Spo_like; cd05399 272562002598 synthetase active site [active] 272562002599 NTP binding site [chemical binding]; other site 272562002600 metal binding site [ion binding]; metal-binding site 272562002601 Spore germination protein; Region: Spore_permease; cl17796 272562002602 Bacillus/Clostridium GerA spore germination protein; Region: GerA; pfam03323 272562002603 germination protein, Ger(x)C family; Region: spore_ger_x_C; TIGR02887 272562002604 leucyl-tRNA synthetase; Validated; Region: leuS; PRK00390 272562002605 catalytic core domain of leucyl-tRNA synthetases; Region: LeuRS_core; cd00812 272562002606 active site 272562002607 HIGH motif; other site 272562002608 Leucyl-tRNA synthetase, Domain 2; Region: tRNA-synt_1_2; pfam13603 272562002609 KMSKS motif; other site 272562002610 Anticodon-binding domain of bacterial and eukaryotic mitochondrial leucyl tRNA synthetases; Region: Anticodon_Ia_Leu_BEm; cd07958 272562002611 tRNA binding surface [nucleotide binding]; other site 272562002612 DnaJ domain or J-domain. DnaJ/Hsp40 (heat shock protein 40) proteins are highly conserved and play crucial roles in protein translation, folding, unfolding, translocation, and degradation. They act primarily by stimulating the ATPase activity of Hsp70s; Region: DnaJ; cd06257 272562002613 DnaJ-class molecular chaperone with C-terminal Zn finger domain [Posttranslational modification, protein turnover, chaperones]; Region: DnaJ; COG0484 272562002614 HSP70 interaction site [polypeptide binding]; other site 272562002615 TPR repeat; Region: TPR_11; pfam13414 272562002616 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 272562002617 binding surface 272562002618 Adenylyl cyclase (AC) class IV-like, a subgroup of the CYTH-like superfamily; Region: CYTH-like_AC_IV-like; cd07890 272562002619 putative active site [active] 272562002620 putative metal binding residues [ion binding]; other site 272562002621 putative triphosphate binding site [ion binding]; other site 272562002622 signature motif; other site 272562002623 dimer interface [polypeptide binding]; other site 272562002624 37-kD nucleoid-associated bacterial protein; Region: NA37; pfam04245 272562002625 Glycopeptide antibiotics resistance protein [Defense mechanisms]; Region: VanZ; COG4767 272562002626 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 272562002627 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 272562002628 active site 272562002629 phosphorylation site [posttranslational modification] 272562002630 intermolecular recognition site; other site 272562002631 dimerization interface [polypeptide binding]; other site 272562002632 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 272562002633 DNA binding site [nucleotide binding] 272562002634 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 272562002635 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 272562002636 ATP binding site [chemical binding]; other site 272562002637 Mg2+ binding site [ion binding]; other site 272562002638 G-X-G motif; other site 272562002639 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 272562002640 Arylsulfatase regulator (Fe-S oxidoreductase) [General function prediction only]; Region: AslB; COG0641 272562002641 FeS/SAM binding site; other site 272562002642 radical SAM additional 4Fe4S-binding SPASM domain; Region: rSAM_more_4Fe4S; TIGR04085 272562002643 Predicted Zn-dependent peptidases [General function prediction only]; Region: PqqL; COG0612 272562002644 Insulinase (Peptidase family M16); Region: Peptidase_M16; pfam00675 272562002645 Peptidase M16 inactive domain; Region: Peptidase_M16_C; pfam05193 272562002646 ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132 272562002647 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 272562002648 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 272562002649 Walker A/P-loop; other site 272562002650 ATP binding site [chemical binding]; other site 272562002651 Q-loop/lid; other site 272562002652 ABC transporter signature motif; other site 272562002653 Walker B; other site 272562002654 D-loop; other site 272562002655 H-loop/switch region; other site 272562002656 ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653 272562002657 Bacterial extracellular solute-binding protein; Region: SBP_bac_8; pfam13416 272562002658 ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653 272562002659 Bacterial extracellular solute-binding protein; Region: SBP_bac_8; pfam13416 272562002660 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 272562002661 dimer interface [polypeptide binding]; other site 272562002662 conserved gate region; other site 272562002663 ABC-ATPase subunit interface; other site 272562002664 ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395 272562002665 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 272562002666 dimer interface [polypeptide binding]; other site 272562002667 conserved gate region; other site 272562002668 putative PBP binding loops; other site 272562002669 ABC-ATPase subunit interface; other site 272562002670 RND family efflux transporter, MFP subunit; Region: RND_mfp; TIGR01730 272562002671 Biotin-lipoyl like; Region: Biotin_lipoyl_2; cl19169 272562002672 ABC-type antimicrobial peptide transport system, permease component [Defense mechanisms]; Region: SalY; COG0577 272562002673 MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704 272562002674 BFD-like [2Fe-2S] binding domain; Region: Fer2_BFD; pfam04324 272562002675 Domain of unknown function (DUF4363); Region: DUF4363; pfam14276 272562002676 Predicted membrane protein [Function unknown]; Region: COG2323 272562002677 Threonyl-tRNA synthetase [Translation, ribosomal structure and biogenesis]; Region: ThrS; COG0441 272562002678 Uridine monophosphate kinase_like (UMPK_like) is a family of proteins highly similar to the uridine monophosphate kinase (UMPK, EC 2.7.1.48), also known as uridine kinase or uridine-cytidine kinase (UCK); Region: UMPK_like; cd02028 272562002679 active site 272562002680 L-serine dehydratase, iron-sulfur-dependent, beta subunit; Region: sda_beta; TIGR00719 272562002681 Serine dehydratase beta chain; Region: SDH_beta; pfam03315 272562002682 C-terminal ACT domain of the L-serine dehydratase (LSD), iron-sulfur-dependent, beta subunit; Region: ACT_LSD; cd04903 272562002683 putative L-serine binding site [chemical binding]; other site 272562002684 L-serine deaminase [Amino acid transport and metabolism]; Region: SdaA; COG1760 272562002685 Serine dehydratase alpha chain; Region: SDH_alpha; cl12120 272562002686 Phosphatidylserine synthase [Lipid metabolism]; Region: PssA; COG1183 272562002687 CDP-alcohol phosphatidyltransferase; Region: CDP-OH_P_transf; cl00453 272562002688 Uncharacterized conserved protein [Function unknown]; Region: COG0398 272562002689 FOG: CBS domain [General function prediction only]; Region: COG0517 272562002690 The CBS domain, named after human CBS, is a small domain originally identified in cystathionine beta-synthase and is subsequently found in a wide range of different proteins. CBS domains usually occur in tandem repeats. They associate to form a so-called...; Region: CBS_pair_9; cd04622 272562002691 putative lipid kinase; Reviewed; Region: PRK13059 272562002692 Diacylglycerol kinase catalytic domain; Region: DAGK_cat; pfam00781 272562002693 Nitrogen regulatory protein PII [Amino acid transport and metabolism]; Region: GlnK; COG0347 272562002694 Ammonia permease [Inorganic ion transport and metabolism]; Region: AmtB; COG0004 272562002695 Mn2+ and Fe2+ transporters of the NRAMP family [Inorganic ion transport and metabolism]; Region: MntH; COG1914 272562002696 Natural resistance-associated macrophage protein; Region: Nramp; pfam01566 272562002697 spore cortex-lytic enzyme; Region: spore_SleB; TIGR02869 272562002698 Putative peptidoglycan binding domain; Region: PG_binding_1; pfam01471 272562002699 Cell Wall Hydrolase; Region: Hydrolase_2; pfam07486 272562002700 Serine acetyltransferase [Amino acid transport and metabolism]; Region: CysE; COG1045 272562002701 Serine acetyltransferase (SAT): SAT catalyzes the CoA-dependent acetylation of the side chain hydroxyl group of L-serine to form O-acetylserine, as the first step of a two-step biosynthetic pathway in bacteria and plants leading to the formation of...; Region: LbH_SAT; cd03354 272562002702 trimer interface [polypeptide binding]; other site 272562002703 active site 272562002704 substrate binding site [chemical binding]; other site 272562002705 CoA binding site [chemical binding]; other site 272562002706 Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: AGPAT-like; Region: LPLAT_AGPAT-like; cd07989 272562002707 putative acyl-acceptor binding pocket; other site 272562002708 Predicted EndoIII-related endonuclease [DNA replication, recombination, and repair]; Region: Nth; COG0177 272562002709 endonuclease III; includes endonuclease III (DNA-(apurinic or apyrimidinic site) lyase), alkylbase DNA glycosidases (Alka-family) and other DNA glycosidases; Region: ENDO3c; cd00056 272562002710 minor groove reading motif; other site 272562002711 helix-hairpin-helix signature motif; other site 272562002712 substrate binding pocket [chemical binding]; other site 272562002713 active site 272562002714 iron-sulpphur binding domain in DNA-(apurinic or apyrimidinic site) lyase (subfamily of ENDO3); Region: FES; smart00525 272562002715 M42 Peptidase, Endoglucanase-like subfamily; Region: M42_glucanase_like; cd05657 272562002716 putative oligomer interface [polypeptide binding]; other site 272562002717 putative active site [active] 272562002718 metal binding site [ion binding]; metal-binding site 272562002719 Uncharacterized vancomycin resistance protein [Defense mechanisms]; Region: COG2720 272562002720 Putative peptidoglycan binding domain; Region: PG_binding_4; pfam12229 272562002721 VanW like protein; Region: VanW; pfam04294 272562002722 glucuronate isomerase; Reviewed; Region: PRK02925 272562002723 Transcriptional regulators [Transcription]; Region: PurR; COG1609 272562002724 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 272562002725 DNA binding site [nucleotide binding] 272562002726 domain linker motif; other site 272562002727 Ligand binding domain of the LacI tanscriptional regulator family belonging to the type I periplasmic-binding fold protein superfamily; Region: PBP1_LacI_sugar_binding_like; cd06267 272562002728 dimerization interface [polypeptide binding]; other site 272562002729 ligand binding site [chemical binding]; other site 272562002730 Na+/melibiose symporter and related transporters [Carbohydrate transport and metabolism]; Region: MelB; COG2211 272562002731 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 272562002732 putative substrate translocation pore; other site 272562002733 altronate oxidoreductase; Provisional; Region: PRK03643 272562002734 Mannitol dehydrogenase Rossmann domain; Region: Mannitol_dh; pfam01232 272562002735 Mannitol dehydrogenase C-terminal domain; Region: Mannitol_dh_C; pfam08125 272562002736 Domains similar to fish antifreeze type III protein; Region: SAF_AH_GD; cd11613 272562002737 galactarate dehydratase; Region: galactar-dH20; TIGR03248 272562002738 D-galactarate dehydratase / Altronate hydrolase, C terminus; Region: GD_AH_C; pfam04295 272562002739 aldose 1-epimerase superfamily; Region: Aldose_epim; cd01081 272562002740 active site 272562002741 catalytic residues [active] 272562002742 Predicted hydrolases of the HAD superfamily [General function prediction only]; Region: Cof; COG0561 272562002743 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 272562002744 haloacid dehalogenase-like hydrolase; Region: HAD; cl19137 272562002745 active site 272562002746 motif I; other site 272562002747 motif II; other site 272562002748 haloacid dehalogenase-like hydrolase; Region: HAD; cl19137 272562002749 spore photoproduct lyase; Region: photo_TT_lyase; TIGR04070 272562002750 DNA repair photolyase [DNA replication, recombination, and repair]; Region: SplB; COG1533 272562002751 Predicted rRNA methylase (SpoU class) [Translation, ribosomal structure and biogenesis]; Region: CspR; COG0219 272562002752 EDD domain protein, DegV family; Region: DegV; TIGR00762 272562002753 Periplasmic binding domain of basic membrane lipoprotein, PnrA, in Treponema pallidum and its homologs from other bacteria and Archaea; Region: PBP1_BmpA_PnrA_like; cd06354 272562002754 ligand binding site [chemical binding]; other site 272562002755 ABC-type uncharacterized transport systems, ATPase components [General function prediction only]; Region: COG3845 272562002756 First domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_I; cd03216 272562002757 Walker A/P-loop; other site 272562002758 ATP binding site [chemical binding]; other site 272562002759 Q-loop/lid; other site 272562002760 ABC transporter signature motif; other site 272562002761 Walker B; other site 272562002762 D-loop; other site 272562002763 H-loop/switch region; other site 272562002764 Second domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_II; cd03215 272562002765 Transmembrane subunit (TM) of Treponema pallidum (Tp) RbsC-1, RbsC-2 and related proteins. This is a functionally uncharacterized subgroup of TMs which belong to a larger group of TMs of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette; Region: TM_PBP1_transp_TpRbsC_like; cd06580 272562002766 TM-ABC transporter signature motif; other site 272562002767 Transmembrane subunit (TM) of Treponema pallidum (Tp) RbsC-1, RbsC-2 and related proteins. This is a functionally uncharacterized subgroup of TMs which belong to a larger group of TMs of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette; Region: TM_PBP1_transp_TpRbsC_like; cd06580 272562002768 TM-ABC transporter signature motif; other site 272562002769 Endoglucanase [Carbohydrate transport and metabolism]; Region: BglC; COG2730 272562002770 Cellulase (glycosyl hydrolase family 5); Region: Cellulase; pfam00150 272562002771 Ricin-type beta-trefoil; Carbohydrate-binding domain formed from presumed gene triplication. The domain is found in a variety of molecules serving diverse functions such as enzymatic activity, inhibitory toxicity and signal transduction. Highly specific...; Region: RICIN; cd00161 272562002772 Ricin-type beta-trefoil lectin domain; Region: Ricin_B_lectin; pfam00652 272562002773 putative sugar binding sites [chemical binding]; other site 272562002774 Q-X-W motif; other site 272562002775 Ricin-type beta-trefoil; Region: RICIN; smart00458 272562002776 Ricin-type beta-trefoil; Carbohydrate-binding domain formed from presumed gene triplication. The domain is found in a variety of molecules serving diverse functions such as enzymatic activity, inhibitory toxicity and signal transduction. Highly specific...; Region: RICIN; cd00161 272562002777 putative sugar binding sites [chemical binding]; other site 272562002778 Q-X-W motif; other site 272562002779 RNA polymerase factor sigma-54; Reviewed; Region: PRK05932 272562002780 Sigma-54 factor, Activator interacting domain (AID); Region: Sigma54_AID; pfam00309 272562002781 Sigma-54 factor, core binding domain; Region: Sigma54_CBD; pfam04963 272562002782 Sigma-54, DNA binding domain; Region: Sigma54_DBD; pfam04552 272562002783 Transcriptional regulator, contains sigma factor-related N-terminal domain [Transcription]; Region: DeoR; COG2390 272562002784 Predicted transcriptional regulator [Transcription]; Region: COG3388 272562002785 Putative sugar-binding domain; Region: Sugar-bind; pfam04198 272562002786 Glyceraldehyde-3-phosphate dehydrogenase/erythrose-4-phosphate dehydrogenase [Carbohydrate transport and metabolism]; Region: GapA; COG0057 272562002787 Glyceraldehyde 3-phosphate dehydrogenase, NAD binding domain; Region: Gp_dh_N; smart00846 272562002788 Glyceraldehyde 3-phosphate dehydrogenase, C-terminal domain; Region: Gp_dh_C; pfam02800 272562002789 Phosphoglycerate kinase (PGK) is a monomeric enzyme which catalyzes the transfer of the high-energy phosphate group of 1,3-bisphosphoglycerate to ADP, forming ATP and 3-phosphoglycerate. This reaction represents the first of the two substrate-level...; Region: Phosphoglycerate_kinase; cd00318 272562002790 substrate binding site [chemical binding]; other site 272562002791 hinge regions; other site 272562002792 ADP binding site [chemical binding]; other site 272562002793 catalytic site [active] 272562002794 Triosephosphate isomerase (TIM) is a glycolytic enzyme that catalyzes the interconversion of dihydroxyacetone phosphate and D-glyceraldehyde-3-phosphate. The reaction is very efficient and requires neither cofactors nor metal ions. TIM, usually...; Region: TIM; cd00311 272562002795 substrate binding site [chemical binding]; other site 272562002796 dimer interface [polypeptide binding]; other site 272562002797 catalytic triad [active] 272562002798 phosphoglyceromutase; Provisional; Region: PRK05434 272562002799 enolase; Provisional; Region: eno; PRK00077 272562002800 Enolase: Enolases are homodimeric enzymes that catalyse the reversible dehydration of 2-phospho-D-glycerate to phosphoenolpyruvate as part of the glycolytic and gluconeogenesis pathways. The reaction is facilitated by the presence of metal ions; Region: enolase; cd03313 272562002801 dimer interface [polypeptide binding]; other site 272562002802 metal binding site [ion binding]; metal-binding site 272562002803 substrate binding pocket [chemical binding]; other site 272562002804 Preprotein translocase subunit SecG [Intracellular trafficking and secretion]; Region: SecG; COG1314 272562002805 ribonuclease R; Region: RNase_R; TIGR02063 272562002806 Ribonuclease B OB domain; Region: OB_RNB; pfam08206 272562002807 Ribonuclease B OB domain; Region: OB_RNB; pfam08206 272562002808 This domain is the catalytic domain of ribonuclease II; Region: RNB; smart00955 272562002809 S1_RNase_R: RNase R C-terminal S1 domain. RNase R is a processive 3' to 5' exoribonuclease, which is a homolog of RNase II. RNase R degrades RNA with secondary structure having a 3' overhang of at least 7 nucleotides. RNase R and PNPase...; Region: S1_RNase_R; cd04471 272562002810 RNA binding site [nucleotide binding]; other site 272562002811 Small protein B (SmpB) is a component of the trans-translation system in prokaryotes for releasing stalled ribosome from damaged messenger RNAs; Region: SmpB; cd09294 272562002812 SmpB-tmRNA interface; other site 272562002813 This group contains class II terpene cyclases, protein prenyltransferases beta subunit, two broadly specific proteinase inhibitors alpha2-macroglobulin (alpha (2)-M) and pregnancy zone protein (PZP) and, the C3 C4 and C5 components of vertebrate...; Region: ISOPREN_C2_like; cl08267 272562002814 This family contains NADPH-dependent flavin reductase and oxygen-insensitive nitroreductase. These enzymes are homodimeric flavoproteins that contain one FMN per monomer as a cofactor. Flavin reductase catalyzes the reduction of flavin by using NADPH as...; Region: NfsA_FRP; cd02146 272562002815 dimer interface [polypeptide binding]; other site 272562002816 FMN binding site [chemical binding]; other site 272562002817 NADPH bind site [chemical binding]; other site 272562002818 Epoxide hydrolase N terminus; Region: EHN; pfam06441 272562002819 Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596 272562002820 Protein of unknown function with HXXEE motif; Region: HXXEE; pfam13787 272562002821 probable dihydroxyacetone kinase regulator; Region: DHAK_reg; TIGR02366 272562002822 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 272562002823 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 272562002824 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 272562002825 Protein of unknown function with HXXEE motif; Region: HXXEE; pfam13787 272562002826 Ribose 5-phosphate isomerase RpiB [Carbohydrate transport and metabolism]; Region: RpiB; COG0698 272562002827 putative transport protein YifK; Provisional; Region: PRK10746 272562002828 Methyltransferase domain; Region: Methyltransf_31; pfam13847 272562002829 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 272562002830 S-adenosylmethionine binding site [chemical binding]; other site 272562002831 Domain of unknown function (DUF4317); Region: DUF4317; pfam14199 272562002832 Predicted permease, member of the PurR regulon [General function prediction only]; Region: yhhT; COG0628 272562002833 Nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: WcaG; COG0451 272562002834 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 272562002835 NAD(P) binding site [chemical binding]; other site 272562002836 active site 272562002837 Domain of unknown function (DUF4118); Region: DUF4118; pfam13493 272562002838 GAF domain; Region: GAF_3; pfam13492 272562002839 Uncharacterized protein conserved in bacteria (DUF2194); Region: DUF2194; pfam09960 272562002840 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4878 272562002841 Putative NodB-like catalytic domain of uncharacterized proteins found in bacteria; Region: CE4_COG4878; cd10924 272562002842 NodB motif; other site 272562002843 putative active site [active] 272562002844 putative catalytic site [active] 272562002845 putative Zn binding site [ion binding]; other site 272562002846 This family is most closely related to the GT1 family of glycosyltransferases. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can...; Region: GT1_like_3; cd03813 272562002847 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 272562002848 Predicted membrane protein [Function unknown]; Region: COG4267 272562002849 Uncharacterized conserved protein [Function unknown]; Region: COG3868 272562002850 glutamate dehydrogenase; Provisional; Region: PRK09414 272562002851 Glu/Leu/Phe/Val dehydrogenase, dimerization domain; Region: ELFV_dehydrog_N; pfam02812 272562002852 NAD(P) binding domain of glutamate dehydrogenase, subgroup 2; Region: NAD_bind_2_Glu_DH; cd05313 272562002853 NAD(P) binding site [chemical binding]; other site 272562002854 DNA polymerase III subunit epsilon; Validated; Region: PRK06195 272562002855 an uncharacterized bacterial subgroup of the DEDDh 3'-5' exonuclease domain family with similarity to the epsilon subunit of DNA polymerase III; Region: DNA_pol_III_epsilon_like; cd06130 272562002856 active site 272562002857 catalytic site [active] 272562002858 substrate binding site [chemical binding]; other site 272562002859 Breast Cancer Suppressor Protein (BRCA1), carboxy-terminal domain. The BRCT domain is found within many DNA damage repair and cell cycle checkpoint proteins. The unique diversity of this domain superfamily allows BRCT modules to interact forming homo...; Region: BRCT; cd00027 272562002860 Dimer interface [polypeptide binding]; other site 272562002861 BRCT sequence motif; other site 272562002862 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG1550 272562002863 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cl19050 272562002864 dimer interface [polypeptide binding]; other site 272562002865 putative CheW interface [polypeptide binding]; other site 272562002866 Membrane-associated phospholipid phosphatase [Lipid metabolism]; Region: PgpB; COG0671 272562002867 PAP2, bacterial acid phosphatase or class A non-specific acid phosphatases. These enzymes catalyze phosphomonoester hydrolysis, with optimal activity in low pH conditions. They are secreted into the periplasmic space, and their physiological role remains...; Region: PAP2_acid_phosphatase; cd03397 272562002868 active site 272562002869 Autotransporter-associated beta strand repeat; Region: Autotrns_rpt; pfam12951 272562002870 Beta-glucosidase/6-phospho-beta-glucosidase/beta- galactosidase [Carbohydrate transport and metabolism]; Region: BglB; COG2723 272562002871 Glycosyl hydrolase family 1; Region: Glyco_hydro_1; pfam00232 272562002872 Na+/H+ antiporter [Energy production and conversion]; Region: NhaC; COG1757 272562002873 Na+/H+ antiporter family; Region: Na_H_antiporter; pfam03553 272562002874 Transcriptional regulator [Transcription]; Region: LysR; COG0583 272562002875 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 272562002876 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cd05466 272562002877 dimerization interface [polypeptide binding]; other site 272562002878 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4412 272562002879 Immune inhibitor A peptidase M6; Region: Peptidase_M6; pfam05547 272562002880 Putative peptidoglycan binding domain; Region: PG_binding_4; pfam12229 272562002881 Uncharacterized protein conserved in bacteria [Function unknown]; Region: ErfK; COG1376 272562002882 Putative peptidoglycan binding domain; Region: PG_binding_4; pfam12229 272562002883 L,D-transpeptidase catalytic domain; Region: YkuD; pfam03734 272562002884 Proteins of this family catalyze the reduction of flavin or nitrocompounds using NAD(P)H as electron donor in a obligatory two-electron transfer, utilizing FMN or FAD as cofactor. They are often found to be homodimers. Enzymes of this family are...; Region: Nitro_FMN_reductase; cl00514 272562002885 FMN binding site [chemical binding]; other site 272562002886 dimer interface [polypeptide binding]; other site 272562002887 Nitroreductase family; Region: Nitroreductase; pfam00881 272562002888 Predicted HD-superfamily hydrolase [General function prediction only]; Region: COG3481 272562002889 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 272562002890 Zn2+ binding site [ion binding]; other site 272562002891 Mg2+ binding site [ion binding]; other site 272562002892 Dipeptide/tripeptide permease [Amino acid transport and metabolism]; Region: PTR2; COG3104 272562002893 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 272562002894 putative substrate translocation pore; other site 272562002895 Adenylation domain of proteins similar to ATP-dependent polynucleotide ligases; Region: Adenylation_DNA_ligase_like; cl12015 272562002896 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 272562002897 Zn2+ binding site [ion binding]; other site 272562002898 Mg2+ binding site [ion binding]; other site 272562002899 Predicted kinase [General function prediction only]; Region: COG4639 272562002900 AAA domain; Region: AAA_33; pfam13671 272562002901 SseB protein N-terminal domain; Region: SseB; pfam07179 272562002902 SseB protein C-terminal domain; Region: SseB_C; pfam14581 272562002903 NADPH-dependent FMN reductase; Region: FMN_red; cl00438 272562002904 Multimeric flavodoxin WrbA [General function prediction only]; Region: WrbA; COG0655 272562002905 Bystin; Region: Bystin; pfam05291 272562002906 Tim44 is an essential component of the machinery that mediates the translocation of nuclear-encoded proteins across the mitochondrial inner membrane; Region: Tim44; smart00978 272562002907 hybrid cluster protein-associated redox disulfide domain; Region: prismane_assoc; TIGR03980 272562002908 Uncharacterized conserved protein [Function unknown]; Region: COG3945 272562002909 Fe binding site [ion binding]; other site 272562002910 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 272562002911 Major Facilitator Superfamily; Region: MFS_1; pfam07690 272562002912 putative substrate translocation pore; other site 272562002913 Transcriptional regulators [Transcription]; Region: MarR; COG1846 272562002914 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cl17220 272562002915 dihydropyrimidine dehydrogenase subunit A; Provisional; Region: PRK11749 272562002916 Dihydroprymidine dehydrogenase domain II, 4Fe-4S cluster; Region: Fer4_20; pfam14691 272562002917 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl19134 272562002918 Alanine dehydrogenase/PNT, C-terminal domain; Region: AlaDh_PNT_C; cl19125 272562002919 Predicted oxidoreductases of the aldo/keto reductase family [General function prediction only]; Region: COG1453 272562002920 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 272562002921 active site 272562002922 catalytic tetrad [active] 272562002923 4Fe-4S dicluster domain; Region: Fer4_17; pfam13534 272562002924 Predicted transcriptional regulators [Transcription]; Region: SoxR; COG0789 272562002925 Helix-Turn-Helix DNA binding domain of the MerR-like transcription regulators YyaN and YraB; Region: HTH_YyaN; cd01109 272562002926 DNA binding residues [nucleotide binding] 272562002927 putative dimer interface [polypeptide binding]; other site 272562002928 Predicted oxidoreductases of the aldo/keto reductase family [General function prediction only]; Region: COG1453 272562002929 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 272562002930 active site 272562002931 catalytic tetrad [active] 272562002932 4Fe-4S dicluster domain; Region: Fer4_17; pfam13534 272562002933 Transcriptional regulator [Transcription]; Region: LysR; COG0583 272562002934 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 272562002935 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cd05466 272562002936 dimerization interface [polypeptide binding]; other site 272562002937 Uncharacterized conserved protein [Function unknown]; Region: COG3875 272562002938 Major intrinsic protein (MIP) superfamily. Members of the MIP superfamily function as membrane channels that selectively transport water, small neutral molecules, and ions out of and between cells. The channel proteins share a common fold: the N-terminal...; Region: MIP; cd00333 272562002939 amphipathic channel; other site 272562002940 Asn-Pro-Ala signature motifs; other site 272562002941 cobalt transport protein CbiM; Provisional; Region: PRK07331 272562002942 Cobalt uptake substrate-specific transmembrane region; Region: CbiM; cl00397 272562002943 PDGLE domain; Region: PDGLE; pfam13190 272562002944 ABC-type cobalt transport system, permease component CbiQ and related transporters [Inorganic ion transport and metabolism]; Region: CbiQ; COG0619 272562002945 ABC-type cobalt transport system, ATPase component [Inorganic ion transport and metabolism]; Region: CbiO; COG1122 272562002946 First domain of the ATP-binding cassette component of cobalt transport system; Region: ABC_cobalt_CbiO_domain1; cd03225 272562002947 Walker A/P-loop; other site 272562002948 ATP binding site [chemical binding]; other site 272562002949 Q-loop/lid; other site 272562002950 ABC transporter signature motif; other site 272562002951 Walker B; other site 272562002952 D-loop; other site 272562002953 H-loop/switch region; other site 272562002954 hypothetical protein; Provisional; Region: PRK04194 272562002955 ATP-utilizing enzymes of the PP-loop superfamily [General function prediction only]; Region: COG1606 272562002956 This is a subfamily of Adenine nucleotide alpha hydrolases superfamily. Adenine nucleotide alpha hydrolases superfamily includes N type ATP PPases and ATP sulphurylases. It forms a apha/beta/apha fold which binds to Adenosine group. This subfamily; Region: Alpha_ANH_like_I; cd01990 272562002957 Ligand Binding Site [chemical binding]; other site 272562002958 NCAIR mutase (PurE)-related proteins [General function prediction only]; Region: COG1691 272562002959 AIR carboxylase; Region: AIRC; smart01001 272562002960 Acetyltransferase (isoleucine patch superfamily) [General function prediction only]; Region: WbbJ; COG0110 272562002961 Xenobiotic acyltransferase (XAT): The XAT class of hexapeptide acyltransferases is composed of a large number of microbial enzymes that catalyze the CoA-dependent acetylation of a variety of hydroxyl-bearing acceptors such as chloramphenicol and...; Region: LbH_XAT; cd03349 272562002962 trimer interface [polypeptide binding]; other site 272562002963 active site 272562002964 substrate binding site [chemical binding]; other site 272562002965 CoA binding site [chemical binding]; other site 272562002966 Superfamily II DNA and RNA helicases [DNA replication, recombination, and repair / Transcription / Translation, ribosomal structure and biogenesis]; Region: SrmB; COG0513 272562002967 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 272562002968 ATP binding site [chemical binding]; other site 272562002969 putative Mg++ binding site [ion binding]; other site 272562002970 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 272562002971 nucleotide binding region [chemical binding]; other site 272562002972 ATP-binding site [chemical binding]; other site 272562002973 Mitochondrial degradasome RNA helicase subunit C terminal; Region: SUV3_C; pfam12513 272562002974 Cysteine hydrolases; This family contains amidohydrolases, like CSHase (N-carbamoylsarcosine amidohydrolase), involved in creatine metabolism and nicotinamidase, converting nicotinamide to nicotinic acid and ammonia in the pyridine nucleotide cycle. It...; Region: cysteine_hydrolases; cd00431 272562002975 catalytic triad [active] 272562002976 conserved cis-peptide bond; other site 272562002977 tyrosyl-tRNA synthetase; Provisional; Region: PRK13354 272562002978 catalytic core domain of tyrosinyl-tRNA synthetase; Region: TyrRS_core; cd00805 272562002979 active site 272562002980 HIGH motif; other site 272562002981 dimer interface [polypeptide binding]; other site 272562002982 KMSKS motif; other site 272562002983 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 272562002984 RNA binding surface [nucleotide binding]; other site 272562002985 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4296 272562002986 Pentapeptide repeats containing protein [Function unknown]; Region: COG1357 272562002987 Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805 272562002988 DEAD-box helicases. A diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker B motif; Region: DEADc; cd00268 272562002989 DEAD-like helicases superfamily; Region: DEXDc; smart00487 272562002990 ATP binding site [chemical binding]; other site 272562002991 Mg++ binding site [ion binding]; other site 272562002992 motif III; other site 272562002993 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 272562002994 nucleotide binding region [chemical binding]; other site 272562002995 ATP-binding site [chemical binding]; other site 272562002996 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3861 272562002997 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3861 272562002998 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550 272562002999 ABC-ATPase subunit interface; other site 272562003000 dimer interface [polypeptide binding]; other site 272562003001 putative PBP binding regions; other site 272562003002 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550 272562003003 ABC-ATPase subunit interface; other site 272562003004 dimer interface [polypeptide binding]; other site 272562003005 putative PBP binding regions; other site 272562003006 ABC-type Fe3+-hydroxamate transport system, periplasmic component [Inorganic ion transport and metabolism]; Region: FepB; COG0614 272562003007 Periplasmic binding protein FeuA. These proteins have predicted to function as initial receptors in ABC transport of metal ions in some eubacterial species. They belong to the TroA superfamily of periplasmic metal binding proteins that share a distinct...; Region: FeuA; cd01138 272562003008 putative ligand binding residues [chemical binding]; other site 272562003009 ABC-type cobalamin/Fe3+-siderophores transport systems, ATPase components [Inorganic ion transport and metabolism / Coenzyme metabolism]; Region: FepC; COG1120 272562003010 ATP-binding component of iron-siderophores, vitamin B12 and hemin transporters and related proteins; Region: ABC_Iron-Siderophores_B12_Hemin; cd03214 272562003011 Walker A/P-loop; other site 272562003012 ATP binding site [chemical binding]; other site 272562003013 Q-loop/lid; other site 272562003014 ABC transporter signature motif; other site 272562003015 Walker B; other site 272562003016 D-loop; other site 272562003017 H-loop/switch region; other site 272562003018 D-Alanine aminotransferase (D-AAT_like): D-amino acid aminotransferase catalyzes transamination between D-amino acids and their respective alpha-keto acids. It plays a major role in the synthesis of bacterial cell wall components like D-alanine and...; Region: D-AAT_like; cd01558 272562003019 homodimer interface [polypeptide binding]; other site 272562003020 substrate-cofactor binding pocket; other site 272562003021 pyridoxal 5'-phosphate binding site [chemical binding]; other site 272562003022 catalytic residue [active] 272562003023 Plant protein of unknown function (DUF946); Region: DUF946; pfam06101 272562003024 Nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: WcaG; COG0451 272562003025 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 272562003026 NAD(P) binding site [chemical binding]; other site 272562003027 active site 272562003028 Glycosyltransferase like family 2; Region: Glyco_tranf_2_3; pfam13641 272562003029 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cd00761 272562003030 active site 272562003031 Putative integral membrane protein DUF46; Region: DUF46; cl17511 272562003032 Phosphoenolpyruvate synthase/pyruvate phosphate dikinase [Carbohydrate transport and metabolism]; Region: PpsA; COG0574 272562003033 Pyruvate phosphate dikinase, PEP/pyruvate binding domain; Region: PPDK_N; pfam01326 272562003034 PEP-utilizing enzyme, mobile domain; Region: PEP-utilizers; pfam00391 272562003035 Phosphatidylserine synthase [Lipid metabolism]; Region: PssA; COG1183 272562003036 CDP-alcohol phosphatidyltransferase; Region: CDP-OH_P_transf; cl00453 272562003037 Phosphatidylserine decarboxylase; Region: PS_Dcarbxylase; cl03656 272562003038 prenyltransferase; Provisional; Region: ubiA; PRK13592 272562003039 phosphoenolpyruvate synthase; Validated; Region: PRK06241 272562003040 Pyruvate phosphate dikinase, PEP/pyruvate binding domain; Region: PPDK_N; pfam01326 272562003041 PEP-utilizing enzyme, mobile domain; Region: PEP-utilizers; pfam00391 272562003042 Pectate lyase [Carbohydrate transport and metabolism]; Region: PelB; COG3866 272562003043 Pectate lyase; Region: Pec_lyase_C; cl01593 272562003044 ligand binding domain of Tar- and Tsr-related chemoreceptors; Region: Tar_Tsr_LBD; cl00144 272562003045 Cache domain; Region: Cache_1; pfam02743 272562003046 Methyl-accepting chemotaxis protein [Cell motility and secretion / Signal transduction mechanisms]; Region: Tar; COG0840 272562003047 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 272562003048 dimerization interface [polypeptide binding]; other site 272562003049 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cl19050 272562003050 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 272562003051 dimer interface [polypeptide binding]; other site 272562003052 putative CheW interface [polypeptide binding]; other site 272562003053 Cold-Shock Protein (CSP) contains an S1-like cold-shock domain (CSD) that is found in eukaryotes, prokaryotes, and archaea. CSP's include the major cold-shock proteins CspA and CspB in bacteria and the eukaryotic gene regulatory factor Y-box...; Region: CSP_CDS; cd04458 272562003054 DNA-binding site [nucleotide binding]; DNA binding site 272562003055 RNA-binding motif; other site 272562003056 Hydrogenase maturation factor [Posttranslational modification, protein turnover, chaperones]; Region: HypC; COG0298 272562003057 HypE (Hydrogenase expression/formation protein). HypE is involved in Ni-Fe hydrogenase biosynthesis. HypE dehydrates its own carbamoyl moiety in an ATP-dependent process to yield the enzyme thiocyanate. The N-terminal domain of HypE is related to the...; Region: HypE; cd02197 272562003058 dimerization interface [polypeptide binding]; other site 272562003059 hydrogenase expression/formation protein HypE; Region: hypE; TIGR02124 272562003060 ATP binding site [chemical binding]; other site 272562003061 Acylphosphatase; Region: Acylphosphatase; pfam00708 272562003062 Hydrogenase maturation factor [Posttranslational modification, protein turnover, chaperones]; Region: HypF; COG0068 272562003063 HypF finger; Region: zf-HYPF; pfam07503 272562003064 HypF finger; Region: zf-HYPF; pfam07503 272562003065 Telomere recombination; Region: Sua5_yciO_yrdC; pfam01300 272562003066 hydrogenase isoenzymes formation protein HypD; Provisional; Region: PRK15062 272562003067 parallel beta-helix repeat-containing protein; Region: beta_helix_1; TIGR03805 272562003068 Zinc dependent phospholipase C; Region: Zn_dep_PLPC; pfam00882 272562003069 3-oxoacyl-[acyl-carrier-protein]; Region: FabH; COG0332 272562003070 Ketoacyl-acyl carrier protein synthase III (KASIII) initiates the elongation in type II fatty acid synthase systems. It is found in bacteria and plants. Elongation of fatty acids in the type II systems occurs by Claisen condensation of malonyl-acyl...; Region: KAS_III; cd00830 272562003071 dimer interface [polypeptide binding]; other site 272562003072 active site 272562003073 CoA binding pocket [chemical binding]; other site 272562003074 Acyltransferase family; Region: Acyl_transf_3; cl19154 272562003075 Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer); Region: MA; smart00283 272562003076 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 272562003077 dimer interface [polypeptide binding]; other site 272562003078 putative CheW interface [polypeptide binding]; other site 272562003079 Putative lysophospholipase; Region: Hydrolase_4; cl19140 272562003080 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 272562003081 7TM diverse intracellular signalling; Region: 7TMR-DISM_7TM; pfam07695 272562003082 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 272562003083 metal binding site [ion binding]; metal-binding site 272562003084 active site 272562003085 I-site; other site 272562003086 phosphoribosylpyrophosphate synthetase; Provisional; Region: PRK06827 272562003087 N-terminal domain of ribose phosphate pyrophosphokinase; Region: Pribosyltran_N; pfam13793 272562003088 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 272562003089 active site 272562003090 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3878 272562003091 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 272562003092 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 272562003093 ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136 272562003094 ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255 272562003095 Walker A/P-loop; other site 272562003096 ATP binding site [chemical binding]; other site 272562003097 Q-loop/lid; other site 272562003098 ABC transporter signature motif; other site 272562003099 Walker B; other site 272562003100 D-loop; other site 272562003101 H-loop/switch region; other site 272562003102 MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704 272562003103 TPR/MLP1/MLP2-like protein; Region: TPR_MLP1_2; pfam07926 272562003104 FtsX-like permease family; Region: FtsX; pfam02687 272562003105 MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704 272562003106 ABC-type antimicrobial peptide transport system, permease component [Defense mechanisms]; Region: SalY; COG0577 272562003107 FtsX-like permease family; Region: FtsX; pfam02687 272562003108 TRX family; composed of two groups: Group I, which includes proteins that exclusively encode a TRX domain; and Group II, which are composed of fusion proteins of TRX and additional domains. Group I TRX is a small ancient protein that alter the redox...; Region: TRX_family; cd02947 272562003109 catalytic residues [active] 272562003110 Endoglucanase [Carbohydrate transport and metabolism]; Region: BglC; COG2730 272562003111 Cellulase (glycosyl hydrolase family 5); Region: Cellulase; pfam00150 272562003112 Endoglucanase [Carbohydrate transport and metabolism]; Region: BglC; COG2730 272562003113 Cellulase (glycosyl hydrolase family 5); Region: Cellulase; pfam00150 272562003114 Tagatose-1,6-bisphosphate (TBP) aldolase and related Type B Class II aldolases. TBP aldolase is a tetrameric class II aldolase that catalyzes the reversible condensation of dihydroxyacetone phosphate with glyceraldehyde 3-phsophate to produce tagatose 1; Region: TBP_aldolase_IIB; cd00947 272562003115 intersubunit interface [polypeptide binding]; other site 272562003116 active site 272562003117 zinc binding site [ion binding]; other site 272562003118 Na+ binding site [ion binding]; other site 272562003119 Glycopeptide antibiotics resistance protein [Defense mechanisms]; Region: VanZ; COG4767 272562003120 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 272562003121 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 272562003122 active site 272562003123 phosphorylation site [posttranslational modification] 272562003124 intermolecular recognition site; other site 272562003125 dimerization interface [polypeptide binding]; other site 272562003126 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 272562003127 DNA binding site [nucleotide binding] 272562003128 Methyl-accepting chemotaxis protein [Cell motility and secretion / Signal transduction mechanisms]; Region: Tar; COG0840 272562003129 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 272562003130 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 272562003131 dimerization interface [polypeptide binding]; other site 272562003132 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 272562003133 dimer interface [polypeptide binding]; other site 272562003134 phosphorylation site [posttranslational modification] 272562003135 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 272562003136 ATP binding site [chemical binding]; other site 272562003137 Mg2+ binding site [ion binding]; other site 272562003138 G-X-G motif; other site 272562003139 Predicted transcriptional regulators [Transcription]; Region: COG1695 272562003140 ABC-type Na+ transport system, ATPase component [Energy production and conversion / Inorganic ion transport and metabolism]; Region: NatA; COG4555 272562003141 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 272562003142 Walker A/P-loop; other site 272562003143 ATP binding site [chemical binding]; other site 272562003144 Q-loop/lid; other site 272562003145 ABC transporter signature motif; other site 272562003146 Walker B; other site 272562003147 D-loop; other site 272562003148 H-loop/switch region; other site 272562003149 ABC-type multidrug transport system, permease component [Defense mechanisms]; Region: COG0842 272562003150 ABC-2 type transporter; Region: ABC2_membrane; cl17235 272562003151 ABC-type multidrug transport system, permease component [Defense mechanisms]; Region: COG0842 272562003152 ABC-2 type transporter; Region: ABC2_membrane; pfam01061 272562003153 Domain of unknown function (DUF386); Region: DUF386; pfam04074 272562003154 Spermidine/putrescine-binding periplasmic protein [Amino acid transport and metabolism]; Region: PotD; COG0687 272562003155 ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653 272562003156 ABC-type spermidine/putrescine transport system, permease component II [Amino acid transport and metabolism]; Region: PotC; COG1177 272562003157 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 272562003158 dimer interface [polypeptide binding]; other site 272562003159 conserved gate region; other site 272562003160 putative PBP binding loops; other site 272562003161 ABC-ATPase subunit interface; other site 272562003162 ABC-type spermidine/putrescine transport system, permease component II [Amino acid transport and metabolism]; Region: PotC; COG1177 272562003163 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 272562003164 dimer interface [polypeptide binding]; other site 272562003165 conserved gate region; other site 272562003166 putative PBP binding loops; other site 272562003167 ABC-ATPase subunit interface; other site 272562003168 ABC-type spermidine/putrescine transport systems, ATPase components [Amino acid transport and metabolism]; Region: PotA; COG3842 272562003169 ATP-binding cassette domain of the polyamine transporter; Region: ABC_PotA_N; cd03300 272562003170 Walker A/P-loop; other site 272562003171 ATP binding site [chemical binding]; other site 272562003172 Q-loop/lid; other site 272562003173 ABC transporter signature motif; other site 272562003174 Walker B; other site 272562003175 D-loop; other site 272562003176 H-loop/switch region; other site 272562003177 TOBE domain; Region: TOBE_2; pfam08402 272562003178 DNA-binding transcriptional repressor PuuR; Provisional; Region: PRK09943 272562003179 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 272562003180 non-specific DNA binding site [nucleotide binding]; other site 272562003181 salt bridge; other site 272562003182 sequence-specific DNA binding site [nucleotide binding]; other site 272562003183 Cupin domain; Region: Cupin_2; pfam07883 272562003184 Barnase, a member of the family of homologous microbial ribonucleases, catalyses the cleavage of single-stranded RNA via a two-step mechanism thought to be similar to that of pancreatic ribonuclease. The mechanism involves a transesterification to give a...; Region: barnase; cd00933 272562003185 active site 272562003186 Barstar is an intracellular inhibitor of barnase, an extracellular ribonuclease of Bacillus amyloliquefaciens. Barstar binds tightly to the barnase active site and sterically blocks it thus inhibiting its potentially lethal RNase activity inside the cell; Region: Barstar; cd05142 272562003187 RNAase interaction site [polypeptide binding]; other site 272562003188 nonheme-containing ferritins; Region: Nonheme_Ferritin; cd01055 272562003189 Ferritin-like domain; Region: Ferritin; pfam00210 272562003190 ferroxidase diiron center [ion binding]; other site 272562003191 Na+-driven multidrug efflux pump [Defense mechanisms]; Region: NorM; COG0534 272562003192 Uncharacterized subfamily of the multidrug and toxic compound extrusion (MATE) proteins; Region: MATE_like_8; cd13134 272562003193 Uncharacterized conserved protein [Function unknown]; Region: COG1284 272562003194 Uncharacterized BCR, YitT family COG1284; Region: DUF161; pfam02588 272562003195 Uncharacterized BCR, YitT family COG1284; Region: DUF161; pfam02588 272562003196 Uncharacterized protein conserved in bacteria (DUF2179); Region: DUF2179; pfam10035 272562003197 Predicted transcriptional regulators [Transcription]; Region: COG1733 272562003198 dimerization interface [polypeptide binding]; other site 272562003199 putative DNA binding site [nucleotide binding]; other site 272562003200 putative Zn2+ binding site [ion binding]; other site 272562003201 Nitroreductase-like family 1. A subfamily of the nitroreductase family containing uncharacterized proteins that are similar to nitroreductase. Nitroreductase catalyzes the reduction of nitroaromatic compounds such as nitrotoluenes, nitrofurans and...; Region: Nitroreductase_1; cd02137 272562003202 dimer interface [polypeptide binding]; other site 272562003203 FMN binding site [chemical binding]; other site 272562003204 The Class III extradiol dioxygenase, 4,5-DOPA Dioxygenase, catalyzes the incorporation of both atoms of molecular oxygen into 4,5-dihydroxy-phenylalanine; Region: 45_DOPA_Dioxygenase; cd07363 272562003205 putative active site [active] 272562003206 metal binding site [ion binding]; metal-binding site 272562003207 Amino acid transporters [Amino acid transport and metabolism]; Region: PotE; COG0531 272562003208 Transmembrane amino acid transporter protein; Region: Aa_trans; cl17468 272562003209 c-di-GMP phosphodiesterase class II (HD-GYP domain) [Signal transduction mechanisms]; Region: COG2206 272562003210 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 272562003211 Zn2+ binding site [ion binding]; other site 272562003212 Mg2+ binding site [ion binding]; other site 272562003213 Translation elongation factors (GTPases) [Translation, ribosomal structure and biogenesis]; Region: FusA; COG0480 272562003214 Tet(M)-like family includes Tet(M), Tet(O), Tet(W), and OtrA, containing tetracycline resistant proteins; Region: TetM_like; cd04168 272562003215 G1 box; other site 272562003216 putative GEF interaction site [polypeptide binding]; other site 272562003217 GTP/Mg2+ binding site [chemical binding]; other site 272562003218 Switch I region; other site 272562003219 G2 box; other site 272562003220 G3 box; other site 272562003221 Switch II region; other site 272562003222 G4 box; other site 272562003223 G5 box; other site 272562003224 Tet_II: This subfamily represents domain II of ribosomal protection proteins Tet(M) and Tet(O). This domain has homology to domain II of the elongation factors EF-G and EF-2. Tet(M) and Tet(O) catalyze the release of tetracycline (Tc) from the ribosome...; Region: Tet_II; cd03690 272562003225 Elongation Factor G-like domain IV. This family includes the translational elongation factor termed EF-2 (for Archaea and Eukarya) and EF-G (for Bacteria), ribosomal protection proteins that mediate tetracycline resistance and, an evolutionarily...; Region: EFG_like_IV; cl02789 272562003226 Tet_C: C-terminus of ribosomal protection proteins Tet(M) and Tet(O). This domain has homology to the C terminal domains of the elongation factors EF-G and EF-2. Tet(M) and Tet(O) catalyze the release of tetracycline (Tc) from the ribosome in a...; Region: Tet_C; cd03711 272562003227 Predicted phosphatase/phosphohexomutase [General function prediction only]; Region: COG0637 272562003228 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 272562003229 active site 272562003230 motif I; other site 272562003231 motif II; other site 272562003232 Transcriptional regulators [Transcription]; Region: PurR; COG1609 272562003233 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 272562003234 DNA binding site [nucleotide binding] 272562003235 domain linker motif; other site 272562003236 Ligand-binding domain of uncharacterized transcription regulator ycjW which is a member of the LacI-GalR family repressors; Region: PBP1_ycjW_transcription_regulator_like; cd06294 272562003237 putative dimerization interface [polypeptide binding]; other site 272562003238 putative ligand binding site [chemical binding]; other site 272562003239 Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013 272562003240 alpha-glucan phosphorylases; Region: more_P_ylases; TIGR02094 272562003241 Acetyltransferases, including N-acetylases of ribosomal proteins [Translation, ribosomal structure and biogenesis]; Region: RimL; COG1670 272562003242 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 272562003243 Coenzyme A binding pocket [chemical binding]; other site 272562003244 Domain of unknown function (DUF4163); Region: DUF4163; pfam13739 272562003245 Protein of unknown function (DUF3298); Region: DUF3298; pfam11738 272562003246 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 272562003247 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 272562003248 active site 272562003249 phosphorylation site [posttranslational modification] 272562003250 intermolecular recognition site; other site 272562003251 dimerization interface [polypeptide binding]; other site 272562003252 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 272562003253 DNA binding site [nucleotide binding] 272562003254 ABC-type multidrug transport system, ATPase component [Defense mechanisms]; Region: CcmA; COG1131 272562003255 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 272562003256 Walker A/P-loop; other site 272562003257 ATP binding site [chemical binding]; other site 272562003258 Q-loop/lid; other site 272562003259 ABC transporter signature motif; other site 272562003260 Walker B; other site 272562003261 D-loop; other site 272562003262 H-loop/switch region; other site 272562003263 ABC-type transport system involved in multi-copper enzyme maturation, permease component [General function prediction only]; Region: NosY; COG1277 272562003264 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 272562003265 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 272562003266 dimer interface [polypeptide binding]; other site 272562003267 phosphorylation site [posttranslational modification] 272562003268 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 272562003269 ATP binding site [chemical binding]; other site 272562003270 Mg2+ binding site [ion binding]; other site 272562003271 G-X-G motif; other site 272562003272 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: COG4585 272562003273 ABC-2 family transporter protein; Region: ABC2_membrane_4; pfam12730 272562003274 Thylakoid formation protein; Region: ThylakoidFormat; cl12138 272562003275 Histidine kinase; Region: HisKA_3; pfam07730 272562003276 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 272562003277 ATP binding site [chemical binding]; other site 272562003278 Mg2+ binding site [ion binding]; other site 272562003279 G-X-G motif; other site 272562003280 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 272562003281 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 272562003282 active site 272562003283 phosphorylation site [posttranslational modification] 272562003284 intermolecular recognition site; other site 272562003285 dimerization interface [polypeptide binding]; other site 272562003286 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 272562003287 DNA binding residues [nucleotide binding] 272562003288 dimerization interface [polypeptide binding]; other site 272562003289 ABC-type multidrug transport system, ATPase component [Defense mechanisms]; Region: CcmA; COG1131 272562003290 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 272562003291 Walker A/P-loop; other site 272562003292 ATP binding site [chemical binding]; other site 272562003293 Q-loop/lid; other site 272562003294 ABC transporter signature motif; other site 272562003295 Walker B; other site 272562003296 D-loop; other site 272562003297 H-loop/switch region; other site 272562003298 ABC-2 family transporter protein; Region: ABC2_membrane_3; pfam12698 272562003299 ABC-2 family transporter protein; Region: ABC2_membrane_4; pfam12730 272562003300 ABC-2 family transporter protein; Region: ABC2_membrane_3; pfam12698 272562003301 YhgE/Pip N-terminal domain; Region: pip_yhgE_Nterm; cl19580 272562003302 thioredoxin-disulfide reductase; Region: TRX_reduct; TIGR01292 272562003303 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl19134 272562003304 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 272562003305 Sulfate transporter family; Region: Sulfate_transp; cl19250 272562003306 xanthine permease; Region: pbuX; TIGR03173 272562003307 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 272562003308 active site 272562003309 EamA-like transporter family; Region: EamA; pfam00892 272562003310 Carboxylate/Amino Acid/Amine Transporter; Region: 2A78; TIGR00950 272562003311 EamA-like transporter family; Region: EamA; pfam00892 272562003312 Transcriptional regulators [Transcription]; Region: MarR; COG1846 272562003313 helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347 272562003314 Cyclopropane fatty acid synthase and related methyltransferases [Cell envelope biogenesis, outer membrane]; Region: Cfa; COG2230 272562003315 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 272562003316 S-adenosylmethionine binding site [chemical binding]; other site 272562003317 ABC-type amino acid transport system, permease component [Amino acid transport and metabolism]; Region: HisM; COG0765 272562003318 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 272562003319 dimer interface [polypeptide binding]; other site 272562003320 conserved gate region; other site 272562003321 putative PBP binding loops; other site 272562003322 ABC-ATPase subunit interface; other site 272562003323 ABC-type polar amino acid transport system, ATPase component [Amino acid transport and metabolism]; Region: GlnQ; COG1126 272562003324 ATP-binding cassette domain of the histidine and glutamine transporters; Region: ABC_HisP_GlnQ; cd03262 272562003325 Walker A/P-loop; other site 272562003326 ATP binding site [chemical binding]; other site 272562003327 Q-loop/lid; other site 272562003328 ABC transporter signature motif; other site 272562003329 Walker B; other site 272562003330 D-loop; other site 272562003331 H-loop/switch region; other site 272562003332 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 272562003333 Bacterial extracellular solute-binding proteins, family 3; Region: SBP_bac_3; pfam00497 272562003334 substrate binding pocket [chemical binding]; other site 272562003335 membrane-bound complex binding site; other site 272562003336 hinge residues; other site 272562003337 Domain of unknown function (DUF1836); Region: DUF1836; pfam08876 272562003338 Predicted membrane protein, hemolysin III homolog [General function prediction only]; Region: COG1272 272562003339 Subfamily of the multidrug and toxic compound extrusion (MATE)-like proteins similar to Streptococcus aureus MepA; Region: MATE_MepA_like; cd13143 272562003340 Na+-driven multidrug efflux pump [Defense mechanisms]; Region: NorM; COG0534 272562003341 effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038 272562003342 cAMP-binding proteins - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases [Signal transduction mechanisms]; Region: Crp; COG0664 272562003343 ligand binding site [chemical binding]; other site 272562003344 flexible hinge region; other site 272562003345 Crp-like helix-turn-helix domain; Region: HTH_Crp_2; pfam13545 272562003346 Ferredoxin [Energy production and conversion]; Region: COG1146 272562003347 Ferredoxin [Energy production and conversion]; Region: Fer; COG1141 272562003348 Adenine deaminase [Nucleotide transport and metabolism]; Region: AdeC; COG1001 272562003349 Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281 272562003350 Adenine deaminase (AdeC) directly deaminates adenine to form hypoxanthine. This reaction is part of one of the adenine salvage pathways, as well as the degradation pathway. It is important for adenine utilization as a purine, as well as a nitrogen source...; Region: AdeC; cd01295 272562003351 active site 272562003352 Phosphoglycerol transferase and related proteins, alkaline phosphatase superfamily [Cell envelope biogenesis, outer membrane]; Region: MdoB; COG1368 272562003353 Sulfatase; Region: Sulfatase; pfam00884 272562003354 Predicted multitransmembrane protein [Function unknown]; Region: COG5438 272562003355 Predicted multitransmembrane protein [Function unknown]; Region: COG5438 272562003356 3-deoxy-7-phosphoheptulonate synthase; Reviewed; Region: PRK08673 272562003357 3-deoxy-D-arabino-heptulosonate 7-phosphate (DAHP) synthase [Amino acid transport and metabolism]; Region: AroA; COG2876 272562003358 Prephenate dehydrogenase [Amino acid transport and metabolism]; Region: TyrA; COG0287 272562003359 prephenate dehydrogenase; Validated; Region: PRK08507 272562003360 Dehydroquinate synthase (DHQS) catalyzes the conversion of DAHP to DHQ in shikimate pathway for aromatic compounds synthesis; Region: DHQS; cd08195 272562003361 active site 272562003362 dimer interface [polypeptide binding]; other site 272562003363 metal binding site [ion binding]; metal-binding site 272562003364 5-enolpyruvylshikimate-3-phosphate synthase [Amino acid transport and metabolism]; Region: AroA; COG0128 272562003365 EPSP synthase domain. 3-phosphoshikimate 1-carboxyvinyltransferase (5-enolpyruvylshikimate-3-phosphate synthase) (EC 2.5.1.19) catalyses the reaction between shikimate-3-phosphate (S3P) and phosphoenolpyruvate (PEP) to form...; Region: EPSP_synthase; cd01556 272562003366 hinge; other site 272562003367 active site 272562003368 Chorismase synthase, the enzyme catalyzing the final step of the shikimate pathway; Region: Chorismate_synthase; cd07304 272562003369 Tetramer interface [polypeptide binding]; other site 272562003370 active site 272562003371 FMN-binding site [chemical binding]; other site 272562003372 monofunctional chorismate mutase, gram positive-type, clade 2; Region: CM_mono_grmpos; TIGR01805 272562003373 Shikimate 5-dehydrogenase [Amino acid transport and metabolism]; Region: AroE; COG0169 272562003374 Shikimate dehydrogenase substrate binding domain; Region: Shikimate_dh_N; pfam08501 272562003375 NAD(P) binding domain of Shikimate dehydrogenase; Region: NAD_bind_Shikimate_DH; cd01065 272562003376 shikimate binding site; other site 272562003377 NAD(P) binding site [chemical binding]; other site 272562003378 Shikimate kinase [Amino acid transport and metabolism]; Region: AroK; COG0703 272562003379 Shikimate kinase (SK) is the fifth enzyme in the shikimate pathway, a seven-step biosynthetic pathway which converts erythrose-4-phosphate to chorismic acid, found in bacteria, fungi and plants. Chorismic acid is a important intermediate in the synthesis...; Region: SK; cd00464 272562003380 ADP binding site [chemical binding]; other site 272562003381 magnesium binding site [ion binding]; other site 272562003382 putative shikimate binding site; other site 272562003383 Dehydroquinase (DHQase), type II. Dehydroquinase (or 3-dehydroquinate dehydratase) catalyzes the reversible dehydration of 3-dehydroquinate to form 3-dehydroshikimate. This reaction is part of two metabolic pathways: the biosynthetic shikimate pathway...; Region: DHQase_II; cd00466 272562003384 trimer interface [polypeptide binding]; other site 272562003385 active site 272562003386 dimer interface [polypeptide binding]; other site 272562003387 Endodeoxyribonuclease RusA; Region: RusA; pfam05866 272562003388 UGMP family protein; Validated; Region: PRK09604 272562003389 BadF/BadG/BcrA/BcrD ATPase family; Region: BcrAD_BadFG; cl17271 272562003390 Inactive homolog of metal-dependent proteases, putative molecular chaperone [Posttranslational modification, protein turnover, chaperones]; Region: COG1214; cl17884 272562003391 phosphate regulon sensor kinase PhoR; Region: phoR_proteo; TIGR02966 272562003392 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 272562003393 putative active site [active] 272562003394 heme pocket [chemical binding]; other site 272562003395 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 272562003396 dimer interface [polypeptide binding]; other site 272562003397 phosphorylation site [posttranslational modification] 272562003398 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 272562003399 ATP binding site [chemical binding]; other site 272562003400 Mg2+ binding site [ion binding]; other site 272562003401 G-X-G motif; other site 272562003402 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 272562003403 ATPases associated with a variety of cellular activities; Region: AAA; smart00382 272562003404 Walker A motif; other site 272562003405 ATP binding site [chemical binding]; other site 272562003406 Walker B motif; other site 272562003407 arginine finger; other site 272562003408 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 272562003409 ATPases associated with a variety of cellular activities; Region: AAA; smart00382 272562003410 Walker A motif; other site 272562003411 ATP binding site [chemical binding]; other site 272562003412 Walker B motif; other site 272562003413 C-terminal, D2-small domain, of ClpB protein; Region: ClpB_D2-small; pfam10431 272562003414 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox_2; pfam07992 272562003415 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl19134 272562003416 Predicted metal-dependent hydrolases related to alanyl-tRNA synthetase HxxxH domain [General function prediction only]; Region: COG2872 272562003417 Threonyl and Alanyl tRNA synthetase second additional domain; Region: tRNA_SAD; cl08469 272562003418 DHHA1 domain; Region: DHHA1; pfam02272 272562003419 Uncharacterized conserved protein [Function unknown]; Region: COG0432 272562003420 Dinucleotide-utilizing enzymes involved in molybdopterin and thiamine biosynthesis family 1 [Coenzyme metabolism]; Region: COG1179 272562003421 Family of activating enzymes (E1) of ubiquitin-like proteins related to the E.coli hypothetical protein ygdL. The common reaction mechanism catalyzed by E1-like enzymes begins with a nucleophilic attack of the C-terminal carboxylate of the ubiquitin-like...; Region: YgdL_like; cd00755 272562003422 putative ATP binding site [chemical binding]; other site 272562003423 putative substrate interface [chemical binding]; other site 272562003424 Cache domain; Region: Cache_1; pfam02743 272562003425 Methyl-accepting chemotaxis protein [Cell motility and secretion / Signal transduction mechanisms]; Region: Tar; COG0840 272562003426 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 272562003427 dimerization interface [polypeptide binding]; other site 272562003428 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cl19050 272562003429 dimer interface [polypeptide binding]; other site 272562003430 putative CheW interface [polypeptide binding]; other site 272562003431 Cellulose binding domain; Region: CBM_3; pfam00942 272562003432 Carbohydrate binding domain X2; Region: CBM_X2; pfam03442 272562003433 Carbohydrate binding domain X2; Region: CBM_X2; pfam03442 272562003434 Type I cohesin domain, interaction partner of dockerin; Region: Type_I_cohesin_like; cd08548 272562003435 dockerin binding interface [polypeptide binding]; other site 272562003436 Endoglucanase [Carbohydrate transport and metabolism]; Region: BglC; COG2730 272562003437 Carbohydrate binding domain X2; Region: CBM_X2; pfam03442 272562003438 Type I cohesin domain, interaction partner of dockerin; Region: Type_I_cohesin_like; cd08548 272562003439 dockerin binding interface [polypeptide binding]; other site 272562003440 Carbohydrate binding domain X2; Region: CBM_X2; pfam03442 272562003441 Type I cohesin domain, interaction partner of dockerin; Region: Type_I_cohesin_like; cd08548 272562003442 dockerin binding interface [polypeptide binding]; other site 272562003443 Carbohydrate binding domain X2; Region: CBM_X2; pfam03442 272562003444 Type I cohesin domain, interaction partner of dockerin; Region: Type_I_cohesin_like; cd08548 272562003445 dockerin binding interface [polypeptide binding]; other site 272562003446 Carbohydrate binding domain X2; Region: CBM_X2; pfam03442 272562003447 Type I cohesin domain, interaction partner of dockerin; Region: Type_I_cohesin_like; cd08548 272562003448 dockerin binding interface [polypeptide binding]; other site 272562003449 Glycosyl hydrolase family 48; Region: Glyco_hydro_48; pfam02011 272562003450 Dockerin type I repeat; Region: Dockerin_1; pfam00404 272562003451 Endoglucanase [Carbohydrate transport and metabolism]; Region: BglC; COG2730 272562003452 Cellulase (glycosyl hydrolase family 5); Region: Cellulase; pfam00150 272562003453 Dockerin type I repeat; Region: Dockerin_1; pfam00404 272562003454 endoglucanase; Region: PLN02420 272562003455 Glycosyl hydrolase family 9; Region: Glyco_hydro_9; pfam00759 272562003456 Cellulose binding domain; Region: CBM_3; smart01067 272562003457 Dockerin type I repeat; Region: Dockerin_1; pfam00404 272562003458 Dockerin type I repeat; Region: Dockerin_1; pfam00404 272562003459 Type I cohesin domain, interaction partner of dockerin; Region: Type_I_cohesin_like; cd08548 272562003460 dockerin binding interface [polypeptide binding]; other site 272562003461 Glycoside hydrolase family 44; Region: Glyco_hydro_44; pfam12891 272562003462 Dockerin type I repeat; Region: Dockerin_1; pfam00404 272562003463 endoglucanase; Region: PLN02420 272562003464 Glycosyl hydrolase family 9; Region: Glyco_hydro_9; pfam00759 272562003465 Cellulose binding domain; Region: CBM_3; smart01067 272562003466 Dockerin type I repeat; Region: Dockerin_1; pfam00404 272562003467 endoglucanase; Region: PLN02420 272562003468 Glycosyl hydrolase family 9; Region: Glyco_hydro_9; pfam00759 272562003469 Sugar-binding cellulase-like; Region: Cellulase-like; cl19200 272562003470 Glycosyl hydrolase catalytic core; Region: Glyco_hydro_cc; pfam11790 272562003471 Dockerin type I repeat; Region: Dockerin_1; pfam00404 272562003472 VPS10 domain; Region: VPS10; smart00602 272562003473 Dockerin type I repeat; Region: Dockerin_1; pfam00404 272562003474 4-Oxalocrotonate Tautomerase: Catalyzes the isomerization of unsaturated ketones. The structure is a homohexamer that is arranged as a trimer of dimers. The hexamer contains six active sites, each formed by residues from three monomers, two from one...; Region: 4Oxalocrotonate_Tautomerase; cl00235 272562003475 Metal-dependent amidase/aminoacylase/carboxypeptidase [General function prediction only]; Region: AbgB; COG1473 272562003476 M20 Peptidase Aminoacyclase-1 YxeP-like proteins, including YxeP, YtnL, YjiB and HipO2; Region: M20_Acy1_YxeP_like; cd05669 272562003477 metal binding site [ion binding]; metal-binding site 272562003478 dimer interface [polypeptide binding]; other site 272562003479 WXG100 family type VII secretion target; Region: WXG100_ESAT6; TIGR03930 272562003480 Apolipophorin-III and similar insect proteins; Region: ApoLp-III_like; cl19113 272562003481 TPR repeat; Region: TPR_11; pfam13414 272562003482 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 272562003483 binding surface 272562003484 TPR motif; other site 272562003485 FOG: TPR repeat [General function prediction only]; Region: NrfG; COG0457 272562003486 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 272562003487 binding surface 272562003488 TPR motif; other site 272562003489 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 272562003490 binding surface 272562003491 TPR motif; other site 272562003492 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 272562003493 TPR motif; other site 272562003494 binding surface 272562003495 Tetratricopeptide repeat; Region: TPR_19; pfam14559 272562003496 Tetratricopeptide repeat; Region: TPR_19; pfam14559 272562003497 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4842 272562003498 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 272562003499 S-adenosylmethionine binding site [chemical binding]; other site 272562003500 DNA methylase; Region: N6_N4_Mtase; cl17433 272562003501 CGS_like: Cystathionine gamma-synthase is a PLP dependent enzyme and catalyzes the committed step of methionine biosynthesis. This pathway is unique to microorganisms and plants, rendering the enzyme an attractive target for the development of...; Region: CGS_like; cd00614 272562003502 homodimer interface [polypeptide binding]; other site 272562003503 substrate-cofactor binding pocket; other site 272562003504 pyridoxal 5'-phosphate binding site [chemical binding]; other site 272562003505 catalytic residue [active] 272562003506 cysteine synthase; Region: PLN02565 272562003507 CBS_like: This subgroup includes Cystathionine beta-synthase (CBS) and Cysteine synthase. CBS is a unique heme-containing enzyme that catalyzes a pyridoxal 5'-phosphate (PLP)-dependent condensation of serine and homocysteine to give cystathionine; Region: CBS_like; cd01561 272562003508 dimer interface [polypeptide binding]; other site 272562003509 pyridoxal 5'-phosphate binding site [chemical binding]; other site 272562003510 catalytic residue [active] 272562003511 Uncharacterized small protein [Function unknown]; Region: COG5583 272562003512 Winged helix-turn-helix DNA-binding; Region: HTH_24; pfam13412 272562003513 Transcriptional regulator/sugar kinase [Transcription / Carbohydrate transport and metabolism]; Region: NagC; COG1940 272562003514 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cl17037 272562003515 phosphodiesterase; Provisional; Region: PRK12704 272562003516 ATP phosphoribosyltransferase involved in histidine biosynthesis [Amino acid transport and metabolism]; Region: HisZ; COG3705 272562003517 Class II Histidinyl-tRNA synthetase (HisRS)-like catalytic core domain. HisRS is a homodimer. It is responsible for the attachment of histidine to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for...; Region: HisRS-like_core; cd00773 272562003518 dimer interface [polypeptide binding]; other site 272562003519 motif 1; other site 272562003520 active site 272562003521 motif 2; other site 272562003522 motif 3; other site 272562003523 ATP phosphoribosyltransferase catalytic subunit; Reviewed; Region: hisG; PRK01686 272562003524 ATP phosphoribosyltransferase [Amino acid transport and metabolism]; Region: HisG; COG0040 272562003525 Histidinol dehydrogenase [Amino acid transport and metabolism]; Region: HisD; COG0141 272562003526 Histidinol dehydrogenase, HisD, E.C 1.1.1.23. Histidinol dehydrogenase catalyzes the last two steps in the L-histidine biosynthesis pathway, which is conserved in bacteria, archaea, fungi, and plants. These last two steps are (i) the NAD-dependent...; Region: Histidinol_dh; cd06572 272562003527 NAD binding site [chemical binding]; other site 272562003528 dimerization interface [polypeptide binding]; other site 272562003529 product binding site; other site 272562003530 substrate binding site [chemical binding]; other site 272562003531 zinc binding site [ion binding]; other site 272562003532 catalytic residues [active] 272562003533 Imidazoleglycerol-phosphate dehydratase; Region: IGPD; cd07914 272562003534 putative active site pocket [active] 272562003535 4-fold oligomerization interface [polypeptide binding]; other site 272562003536 metal binding residues [ion binding]; metal-binding site 272562003537 3-fold/trimer interface [polypeptide binding]; other site 272562003538 Type 1 glutamine amidotransferase (GATase1) domain found in imidazole glycerol phosphate synthase (IGPS); Region: GATase1_IGP_Synthase; cd01748 272562003539 imidazole glycerol phosphate synthase subunit HisH; Provisional; Region: hisH; PRK13142 272562003540 putative active site [active] 272562003541 oxyanion strand; other site 272562003542 catalytic triad [active] 272562003543 HisA. Phosphoribosylformimino-5-aminoimidazole carboxamide ribonucleotide (ProFAR) isomerase catalyzes the fourth step in histidine biosynthesis, an isomerisation of the aminoaldose moiety of ProFAR to the aminoketose of PRFAR (N-(5'-phospho-D-1...; Region: HisA; cd04732 272562003544 catalytic residues [active] 272562003545 The cyclase subunit of imidazoleglycerol phosphate synthase (HisF). Imidazole glycerol phosphate synthase (IGPS) catalyzes the fifth step of histidine biosynthesis, the formation of the imidazole ring. IGPS converts N1-(5'-phosphoribulosyl)...; Region: HisF; cd04731 272562003546 substrate binding site [chemical binding]; other site 272562003547 glutamase interaction surface [polypeptide binding]; other site 272562003548 phosphoribosyl-AMP cyclohydrolase; Reviewed; Region: hisI; PRK00051 272562003549 Nucleoside Triphosphate Pyrophosphohydrolase (EC 3.6.1.8) MazG-like domain found in Escherichia coli phosphoribosyl-ATP pyrophosphohydrolase (HisIE or PRATP-PH) and its homologs; Region: NTP-PPase_HisIE_like; cd11534 272562003550 metal binding site [ion binding]; metal-binding site 272562003551 Transketolase [Carbohydrate transport and metabolism]; Region: TktA; COG0021 272562003552 Thiamine pyrophosphate (TPP) family, Transketolase (TK) subfamily, TPP-binding module; TK catalyzes the transfer of a two-carbon unit from ketose phosphates to aldose phosphates. In heterotrophic organisms, TK provides a link between glycolysis and the...; Region: TPP_TK; cd02012 272562003553 TPP-binding site [chemical binding]; other site 272562003554 dimer interface [polypeptide binding]; other site 272562003555 Pyrimidine (PYR) binding domain of 1-deoxy-D-xylulose-5-phosphate synthase (DXS), transketolase (TK), and related proteins; Region: TPP_PYR_DXS_TK_like; cd07033 272562003556 PYR/PP interface [polypeptide binding]; other site 272562003557 dimer interface [polypeptide binding]; other site 272562003558 TPP binding site [chemical binding]; other site 272562003559 Transketolase, C-terminal domain; Region: Transketolase_C; pfam02780 272562003560 Single-stranded DNA-binding protein [DNA replication, recombination, and repair]; Region: Ssb; COG0629 272562003561 SSB_OBF: A subfamily of OB folds similar to the OB fold of ssDNA-binding protein (SSB). SSBs bind with high affinity to ssDNA. They bind to and protect ssDNA intermediates during DNA metabolic pathways. All bacterial and eukaryotic SSBs studied to date...; Region: SSB_OBF; cd04496 272562003562 dimer interface [polypeptide binding]; other site 272562003563 ssDNA binding site [nucleotide binding]; other site 272562003564 tetramer (dimer of dimers) interface [polypeptide binding]; other site 272562003565 Predicted hydrolase (metallo-beta-lactamase superfamily) [General function prediction only]; Region: ComEC; COG2333 272562003566 Metallo-beta-lactamase superfamily; Region: Lactamase_B; smart00849 272562003567 Predicted membrane protein, hemolysin III homolog [General function prediction only]; Region: COG1272 272562003568 EDD domain protein, DegV family; Region: DegV; TIGR00762 272562003569 Predicted transcriptional regulators [Transcription]; Region: COG1695 272562003570 Predicted membrane protein [Function unknown]; Region: COG1971 272562003571 Domain of unknown function DUF; Region: DUF204; pfam02659 272562003572 Ferric uptake regulator(Fur) and related metalloregulatory proteins; typically iron-dependent, DNA-binding repressors and activators; Region: Fur_like; cd07153 272562003573 metal binding site 2 [ion binding]; metal-binding site 272562003574 putative DNA binding helix; other site 272562003575 metal binding site 1 [ion binding]; metal-binding site 272562003576 dimer interface [polypeptide binding]; other site 272562003577 structural Zn2+ binding site [ion binding]; other site 272562003578 Rhomboid family; Region: Rhomboid; pfam01694 272562003579 FtsH Extracellular; Region: FtsH_ext; pfam06480 272562003580 ATP-dependent Zn proteases [Posttranslational modification, protein turnover, chaperones]; Region: HflB; COG0465 272562003581 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 272562003582 Walker A motif; other site 272562003583 ATP binding site [chemical binding]; other site 272562003584 Walker B motif; other site 272562003585 arginine finger; other site 272562003586 Peptidase family M41; Region: Peptidase_M41; pfam01434 272562003587 Gas vesicle protein [General function prediction only]; Region: GvpP; COG4980 272562003588 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 272562003589 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 272562003590 non-specific DNA binding site [nucleotide binding]; other site 272562003591 salt bridge; other site 272562003592 sequence-specific DNA binding site [nucleotide binding]; other site 272562003593 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 272562003594 binding surface 272562003595 TPR motif; other site 272562003596 Tetratricopeptide repeat; Region: TPR_12; pfam13424 272562003597 Tetratricopeptide repeat; Region: TPR_12; pfam13424 272562003598 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 272562003599 binding surface 272562003600 TPR motif; other site 272562003601 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 272562003602 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 272562003603 non-specific DNA binding site [nucleotide binding]; other site 272562003604 salt bridge; other site 272562003605 sequence-specific DNA binding site [nucleotide binding]; other site 272562003606 ATP-dependent chaperone ClpB; Region: chaperone_ClpB; TIGR03346 272562003607 Clp amino terminal domain; Region: Clp_N; pfam02861 272562003608 Clp amino terminal domain; Region: Clp_N; pfam02861 272562003609 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 272562003610 Walker A motif; other site 272562003611 ATP binding site [chemical binding]; other site 272562003612 Walker B motif; other site 272562003613 arginine finger; other site 272562003614 polyhydroxyalkanoic acid synthase, PhaR subunit; Region: phaR_Bmeg; TIGR02132 272562003615 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 272562003616 Walker A motif; other site 272562003617 ATP binding site [chemical binding]; other site 272562003618 Walker B motif; other site 272562003619 arginine finger; other site 272562003620 C-terminal, D2-small domain, of ClpB protein; Region: ClpB_D2-small; pfam10431 272562003621 Predicted xylanase/chitin deacetylase [Carbohydrate transport and metabolism]; Region: CDA1; COG0726 272562003622 Catalytic NodB homology domain of Streptococcus mutans polysaccharide deacetylase PgdA, Bacillus subtilis YheN, and similar proteins; Region: CE4_SmPgdA_like; cd10944 272562003623 NodB motif; other site 272562003624 active site 272562003625 catalytic site [active] 272562003626 Zn binding site [ion binding]; other site 272562003627 Type 1 glutamine amidotransferase (GATase1) domain found in Cobyric Acid Synthase (CobQ); Region: GATase1_CobQ; cd01750 272562003628 catalytic triad [active] 272562003629 UDP-N-acetylmuramyl tripeptide synthase [Cell envelope biogenesis, outer membrane]; Region: MurE; COG0769 272562003630 Mur ligase middle domain; Region: Mur_ligase_M; pfam08245 272562003631 Domain of unknown function (DUF1727); Region: DUF1727; pfam08353 272562003632 undecaprenyl pyrophosphate phosphatase; Reviewed; Region: PRK12554 272562003633 Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: AGPAT-like; Region: LPLAT_AGPAT-like; cd07989 272562003634 putative acyl-acceptor binding pocket; other site 272562003635 Branched-chain amino acid transport protein; Region: Branch_AA_trans; cl00547 272562003636 AAA domain; Region: AAA_32; pfam13654 272562003637 Isopropylmalate/homocitrate/citramalate synthases [Amino acid transport and metabolism]; Region: LeuA; COG0119 272562003638 Clostridium kluyveri Re-citrate synthase and related proteins, catalytic TIM barrel domain; Region: DRE_TIM_Re_CS; cd07947 272562003639 active site 272562003640 catalytic residues [active] 272562003641 metal binding site [ion binding]; metal-binding site 272562003642 aconitate hydratase; Validated; Region: PRK07229 272562003643 Aconitase catalyzes the reversible isomerization of citrate and isocitrate as part of the TCA cycle; Region: AcnA_Bact; cd01585 272562003644 substrate binding site [chemical binding]; other site 272562003645 ligand binding site [chemical binding]; other site 272562003646 Aconitase swivel domain. Aconitase (aconitate hydratase) catalyzes the reversible isomerization of citrate and isocitrate as part of the TCA cycle. This is the aconitase swivel domain, which undergoes swivelling conformational change in the enzyme...; Region: Aconitase_swivel; cl00215 272562003647 substrate binding site [chemical binding]; other site 272562003648 Isocitrate/isopropylmalate dehydrogenase [Amino acid transport and metabolism]; Region: LeuB; COG0473 272562003649 Argininosuccinate synthase. The Argininosuccinate synthase is a urea cycle enzyme that catalyzes the penultimate step in arginine biosynthesis: the ATP-dependent ligation of citrulline to aspartate to form argininosuccinate, AMP and pyrophosphate . In...; Region: Argininosuccinate_Synthase; cd01999 272562003650 ANP binding site [chemical binding]; other site 272562003651 Substrate Binding Site II [chemical binding]; other site 272562003652 Substrate Binding Site I [chemical binding]; other site 272562003653 argininosuccinate lyase; Provisional; Region: PRK00855 272562003654 Argininosuccinate lyase (argininosuccinase, ASAL); Region: Argininosuccinate_lyase; cd01359 272562003655 active sites [active] 272562003656 tetramer interface [polypeptide binding]; other site 272562003657 Phosphoenolpyruvate carboxykinase (PEPCK), a critical gluconeogenic enzyme, catalyzes the first committed step in the diversion of tricarboxylic acid cycle intermediates toward gluconeogenesis. It catalyzes the reversible decarboxylation and...; Region: PEPCK_HprK; cl00270 272562003658 active site 272562003659 metal-binding site [ion binding] 272562003660 nucleotide-binding site [chemical binding]; other site 272562003661 Uncharacterized conserved protein [Function unknown]; Region: COG2155 272562003662 DNA-binding transcriptional regulator AsnC; Provisional; Region: PRK11179 272562003663 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 272562003664 putative DNA binding site [nucleotide binding]; other site 272562003665 putative Zn2+ binding site [ion binding]; other site 272562003666 AsnC family; Region: AsnC_trans_reg; pfam01037 272562003667 Predicted exonuclease [DNA replication, recombination, and repair]; Region: COG3359 272562003668 RNase_H superfamily; Region: RNase_H_2; pfam13482 272562003669 active site 272562003670 catalytic site [active] 272562003671 substrate binding site [chemical binding]; other site 272562003672 FOG: CBS domain [General function prediction only]; Region: COG0517 272562003673 The CBS domain, named after human CBS, is a small domain originally identified in cystathionine beta-synthase and is subsequently found in a wide range of different proteins. CBS domains usually occur in tandem repeats. They associate to form a so-called...; Region: CBS_pair; cd02205 272562003674 formate acetyltransferase 1; Region: pyr_form_ly_1; TIGR01255 272562003675 Pyruvate formate lyase 1; Region: PFL1; cd01678 272562003676 coenzyme A binding site [chemical binding]; other site 272562003677 active site 272562003678 catalytic residues [active] 272562003679 glycine loop; other site 272562003680 pyruvate formate-lyase 1-activating enzyme; Region: PFLA; TIGR02493 272562003681 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 272562003682 FeS/SAM binding site; other site 272562003683 PilZ domain; Region: PilZ; pfam07238 272562003684 ABC-type metal ion transport system, ATPase component [Inorganic ion transport and metabolism]; Region: AbcC; COG1135 272562003685 ATP-binding cassette domain of methionine transporter; Region: ABC_MetN_methionine_transporter; cd03258 272562003686 Walker A/P-loop; other site 272562003687 ATP binding site [chemical binding]; other site 272562003688 Q-loop/lid; other site 272562003689 ABC transporter signature motif; other site 272562003690 Walker B; other site 272562003691 D-loop; other site 272562003692 H-loop/switch region; other site 272562003693 This domain is found at the C-terminus of ABC transporter proteins involved in D-methionine transport as well as a number of ferredoxin-like proteins; Region: NIL; smart00930 272562003694 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 272562003695 dimer interface [polypeptide binding]; other site 272562003696 conserved gate region; other site 272562003697 putative PBP binding loops; other site 272562003698 ABC-ATPase subunit interface; other site 272562003699 ABC-type metal ion transport system, periplasmic component/surface antigen [Inorganic ion transport and metabolism]; Region: NlpA; COG1464 272562003700 RNase_H superfamily; Region: RNase_H_2; pfam13482 272562003701 glutamyl-tRNA synthetase; Reviewed; Region: gltX; PRK01406 272562003702 catalytic core domain of discriminating glutamyl-tRNA synthetase; Region: GluRS_core; cd00808 272562003703 active site 272562003704 HIGH motif; other site 272562003705 KMSKS motif; other site 272562003706 intracellular protease, PfpI family; Region: PfpI; TIGR01382 272562003707 A type 1 glutamine amidotransferase (GATase1)-like domain found in PfpI from Pyrococcus furiosus; Region: GATase1_PfpI_like; cd03134 272562003708 proposed catalytic triad [active] 272562003709 conserved cys residue [active] 272562003710 Protein of unknown function, DUF488; Region: DUF488; pfam04343 272562003711 D-alanyl-D-alanine carboxypeptidase [Cell envelope biogenesis, outer membrane]; Region: DacC; COG1686 272562003712 Beta-lactamase enzyme family; Region: Beta-lactamase2; cl19191 272562003713 Nucleoside diphosphate kinase [Nucleotide transport and metabolism]; Region: Ndk; COG0105 272562003714 multimer interface [polypeptide binding]; other site 272562003715 homoserine dehydrogenase; Provisional; Region: PRK06349 272562003716 Homoserine dehydrogenase, NAD binding domain; Region: NAD_binding_3; pfam03447 272562003717 Homoserine dehydrogenase; Region: Homoserine_dh; pfam00742 272562003718 ACT_HSDH_Hom CD includes the C-terminal ACT domain of the NAD(P)H-dependent, homoserine dehydrogenase (HSDH) and related domains; Region: ACT_HSDH-Hom; cd04881 272562003719 threonine synthase; Validated; Region: PRK09225 272562003720 Threonine synthase catalyzes the final step of threonine biosynthesis. The conversion of O-phosphohomoserine into threonine and inorganic phosphate is pyridoxal 5'-phosphate dependent. The Thr-synth_1 CD includes members from higher plants; Region: Thr-synth_2; cd01560 272562003721 pyridoxal 5'-phosphate binding site [chemical binding]; other site 272562003722 catalytic residue [active] 272562003723 ASC-1 homology domain, subfamily similar to Enterococcus faecalis Ef3133. The ASCH domain, a small beta-barrel domain found in all three kingdoms of life, resembles the RNA-binding PUA domain and may also interact with RNA. ASCH has been proposed to...; Region: ASCH_Ef3133_like; cd06553 272562003724 aspartate aminotransferase; Provisional; Region: PRK07568 272562003725 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 272562003726 pyridoxal 5'-phosphate binding site [chemical binding]; other site 272562003727 homodimer interface [polypeptide binding]; other site 272562003728 catalytic residue [active] 272562003729 nicotinate phosphoribosyltransferase; Validated; Region: PRK09243 272562003730 Nicotinate phosphoribosyltransferase (NAPRTase), subgroup A. Nicotinate phosphoribosyltransferase catalyses the formation of NAMN and PPi from 5-phosphoribosy -1-pyrophosphate (PRPP) and nicotinic acid, this is the first, and also rate limiting, reaction...; Region: NAPRTase_A; cd01570 272562003731 active site 272562003732 Superfamily I DNA and RNA helicases [DNA replication, recombination, and repair]; Region: UvrD; COG0210 272562003733 UvrD-like helicase C-terminal domain; Region: UvrD_C_2; pfam13538 272562003734 Nudix hydrolase is a superfamily of enzymes found in all three kingdoms of life, and it catalyzes the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+...; Region: Nudix_Hydrolase; cl00447 272562003735 nudix motif; other site 272562003736 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 272562003737 Coenzyme A binding pocket [chemical binding]; other site 272562003738 Putative peptidoglycan-binding domain-containing protein [Cell envelope biogenesis, outer membrane]; Region: COG3409 272562003739 Putative peptidoglycan binding domain; Region: PG_binding_1; pfam01471 272562003740 Putative peptidoglycan binding domain; Region: PG_binding_1; pfam01471 272562003741 D-alanyl-D-alanine carboxypeptidase; Region: VanY; pfam02557 272562003742 Calcineurin-like phosphoesterase; Region: Metallophos; pfam00149 272562003743 active site 272562003744 metal binding site [ion binding]; metal-binding site 272562003745 Uncharacterized conserved protein [Function unknown]; Region: COG3339 272562003746 GtrA-like protein; Region: GtrA; pfam04138 272562003747 Cell division ATPase FtsA [Cell division and chromosome partitioning]; Region: ftsA; COG0849 272562003748 Cell division protein FtsA; Region: FtsA; smart00842 272562003749 Cell division protein FtsA; Region: FtsA; pfam14450 272562003750 Metal-dependent amidase/aminoacylase/carboxypeptidase [General function prediction only]; Region: AbgB; COG1473 272562003751 M20 Peptidase Aminoacylase 1 family; Region: M20_Acy1; cd03886 272562003752 metal binding site [ion binding]; metal-binding site 272562003753 dimer interface [polypeptide binding]; other site 272562003754 Pseudouridylate synthases, 23S RNA-specific [Translation, ribosomal structure and biogenesis]; Region: RluA; COG0564 272562003755 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 272562003756 RNA binding surface [nucleotide binding]; other site 272562003757 Pseudouridine synthase, RsuA/RluD family; Region: PseudoU_synth_RluCD_like; cd02869 272562003758 active site 272562003759 Membrane protein involved in the export of O-antigen and teichoic acid [General function prediction only]; Region: RfbX; COG2244 272562003760 Stage V sporulation protein B, also known as Stage III sporulation protein F, and related proteins; Region: MATE_SpoVB_like; cd13124 272562003761 stage V sporulation protein B; Region: spore_V_B; TIGR02900 272562003762 Multidrug and toxic compound extrusion family and similar proteins; Region: MATE_like; cl09326 272562003763 Glucose/sorbosone dehydrogenases [Carbohydrate transport and metabolism]; Region: COG2133 272562003764 Zinc dependent phospholipase C (alpha toxin); Region: Zn_dep_PLPC; cd11009 272562003765 Zn binding site [ion binding]; other site 272562003766 Fe-S oxidoreductase [Energy production and conversion]; Region: COG1032 272562003767 B12 binding domain_like associated with radical SAM domain. This domain shows similarity with B12 (adenosylcobamide) binding domains found in several enzymes, such as glutamate mutase, methionine synthase and methylmalonyl-CoA mutase, but it lacks the...; Region: radical_SAM_B12_BD; cd02068 272562003768 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 272562003769 FeS/SAM binding site; other site 272562003770 Protein of unknown function (DUF4080); Region: DUF4080; pfam13311 272562003771 Predicted thioesterase involved in non-ribosomal peptide biosynthesis [Secondary metabolites biosynthesis, transport, and catabolism]; Region: GrsT; COG3208 272562003772 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 272562003773 Nicotinate-nucleotide pyrophosphorylase [Coenzyme metabolism]; Region: NadC; COG0157 272562003774 Quinolinate phosphoribosyl transferase (QAPRTase or QPRTase), also called nicotinate-nucleotide pyrophosphorylase, is involved in the de novo synthesis of NAD in both prokaryotes and eukaryotes. It catalyses the reaction of quinolinic acid (QA) with...; Region: QPRTase; cd01572 272562003775 dimerization interface [polypeptide binding]; other site 272562003776 active site 272562003777 L-aspartate oxidase; Provisional; Region: PRK06175 272562003778 FAD binding domain; Region: FAD_binding_2; pfam00890 272562003779 Quinolinate synthetase A protein; Region: NadA; pfam02445 272562003780 Superfamily I DNA and RNA helicases [General function prediction only]; Region: COG3973 272562003781 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 272562003782 ATP binding site [chemical binding]; other site 272562003783 Uncharacterized flavoproteins [Energy production and conversion]; Region: FpaA; COG0426 272562003784 Metallo-beta-lactamase superfamily; Region: Lactamase_B; smart00849 272562003785 NADPH-dependent FMN reductase; Region: FMN_red; cl00438 272562003786 Predicted acetyltransferases and hydrolases with the alpha/beta hydrolase fold [General function prediction only]; Region: LipA; COG1075 272562003787 Fe2+ transport system protein A [Inorganic ion transport and metabolism]; Region: FeoA; COG1918 272562003788 Fe2+ transport system protein A [Inorganic ion transport and metabolism]; Region: FeoA; COG1918 272562003789 Fe2+ transport system protein B [Inorganic ion transport and metabolism]; Region: FeoB; COG0370 272562003790 Ferrous iron transport protein B (FeoB) family; Region: FeoB; cd01879 272562003791 G1 box; other site 272562003792 GTP/Mg2+ binding site [chemical binding]; other site 272562003793 Switch I region; other site 272562003794 G2 box; other site 272562003795 G3 box; other site 272562003796 Switch II region; other site 272562003797 G4 box; other site 272562003798 G5 box; other site 272562003799 Nucleoside recognition; Region: Gate; pfam07670 272562003800 Ferrous iron transport protein B C terminus; Region: FeoB_C; pfam07664 272562003801 Nucleoside recognition; Region: Gate; pfam07670 272562003802 CRISPR/Cas system-associated transcriptional regulator CasRa; Region: CasRa_I-A; cd09655 272562003803 HNH nucleases; HNH endonuclease signature which is found in viral, prokaryotic, and eukaryotic proteins. The alignment includes members of the large group of homing endonucleases, yeast intron 1 protein, MutS, as well as bacterial colicins, pyocins, and...; Region: HNHc; cd00085 272562003804 active site 272562003805 Pyruvate kinase [Carbohydrate transport and metabolism]; Region: PykF; COG0469 272562003806 Pyruvate kinase (PK): Large allosteric enzyme that regulates glycolysis through binding of the substrate, phosphoenolpyruvate, and one or more allosteric effectors. Like other allosteric enzymes, PK has a high substrate affinity R state and a low...; Region: Pyruvate_Kinase; cd00288 272562003807 domain interfaces; other site 272562003808 active site 272562003809 Predicted xylanase/chitin deacetylase [Carbohydrate transport and metabolism]; Region: CDA1; COG0726 272562003810 Catalytic NodB homology domain of Streptococcus mutans polysaccharide deacetylase PgdA, Bacillus subtilis YheN, and similar proteins; Region: CE4_SmPgdA_like; cd10944 272562003811 NodB motif; other site 272562003812 active site 272562003813 catalytic site [active] 272562003814 Zn binding site [ion binding]; other site 272562003815 zinc-ribbon domain; Region: zf-ribbon_3; pfam13248 272562003816 Double zinc ribbon; Region: DZR; pfam12773 272562003817 Yip1 domain; Region: Yip1; pfam04893 272562003818 integral membrane protein, YjbE family; Region: R_switched_YjbE; TIGR03717 272562003819 Imidazolonepropionase and related amidohydrolases [Secondary metabolites biosynthesis, transport, and catabolism]; Region: HutI; COG1228 272562003820 Metallo-dependent hydrolases, subgroup C is part of the superfamily of metallo-dependent hydrolases, a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the...; Region: Met_dep_hydrolase_C; cd01309 272562003821 active site 272562003822 arginyl-tRNA synthetase; Reviewed; Region: PRK12451 272562003823 Arginyl tRNA synthetase N terminal domain; Region: Arg_tRNA_synt_N; pfam03485 272562003824 catalytic core domain of arginyl-tRNA synthetases; Region: ArgRS_core; cd00671 272562003825 active site 272562003826 HIGH motif; other site 272562003827 KMSK motif region; other site 272562003828 Anticodon-binding domain of arginyl tRNA synthetases; Region: Anticodon_Ia_Arg; cd07956 272562003829 tRNA binding surface [nucleotide binding]; other site 272562003830 anticodon binding site; other site 272562003831 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 272562003832 non-specific DNA binding site [nucleotide binding]; other site 272562003833 salt bridge; other site 272562003834 sequence-specific DNA binding site [nucleotide binding]; other site 272562003835 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 272562003836 binding surface 272562003837 Tetratricopeptide repeat; Region: TPR_12; pfam13424 272562003838 TPR motif; other site 272562003839 Tetratricopeptide repeat; Region: TPR_12; pfam13424 272562003840 mycofactocin system FadH/OYE family oxidoreductase 2; Region: mycofact_OYE_2; TIGR03997 272562003841 Old yellow enzyme (OYE)-like FMN binding domain. OYE was the first flavin-dependent enzyme identified, however its true physiological role remains elusive to this day. Each monomer of OYE contains FMN as a non-covalently bound cofactor, uses NADPH as a...; Region: OYE_like_FMN_family; cd02803 272562003842 active site 272562003843 FMN binding site [chemical binding]; other site 272562003844 substrate binding site [chemical binding]; other site 272562003845 putative catalytic residue [active] 272562003846 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl19134 272562003847 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 272562003848 EamA-like transporter family; Region: EamA; pfam00892 272562003849 Carboxylate/Amino Acid/Amine Transporter; Region: 2A78; TIGR00950 272562003850 Transcriptional regulator [Transcription]; Region: LysR; COG0583 272562003851 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 272562003852 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cd05466 272562003853 dimerization interface [polypeptide binding]; other site 272562003854 vitamin B12-dependent ribonucleotide reductase; Validated; Region: PRK06556 272562003855 Class II vitamin B12-dependent ribonucleotide reductase; Region: Ribonuc_red_2_N; pfam08471 272562003856 Class II ribonucleotide reductase, dimeric form; Region: RNR_II_dimer; cd02888 272562003857 active site 272562003858 dimer interface [polypeptide binding]; other site 272562003859 effector binding site; other site 272562003860 TSCPD domain; Region: TSCPD; pfam12637 272562003861 Carbonic anhydrases/acetyltransferases, isoleucine patch superfamily [General function prediction only]; Region: PaaY; COG0663 272562003862 Gamma carbonic anhydrase-like: This family is composed of gamma carbonic anhydrase (CA), Ferripyochelin Binding Protein (FBP), E. coli paaY protein, and similar proteins. CAs are zinc-containing enzymes that catalyze the reversible hydration of carbon...; Region: LbH_gamma_CA_like; cd04645 272562003863 trimer interface [polypeptide binding]; other site 272562003864 putative metal binding site [ion binding]; other site 272562003865 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG1728 272562003866 NAD synthetase; Reviewed; Region: nadE; PRK02628 272562003867 Glutamine aminotransferase (GAT, glutaminase) domain of glutamine-dependent NAD synthetases (class 7 and 8 nitrilases); Region: GAT_Gln-NAD-synth; cd07570 272562003868 multimer interface [polypeptide binding]; other site 272562003869 active site 272562003870 catalytic triad [active] 272562003871 protein interface 1 [polypeptide binding]; other site 272562003872 NAD+ synthase is a homodimer, which catalyzes the final step in de novo nicotinamide adenine dinucleotide (NAD+) biosynthesis, an amide transfer from either ammonia or glutamine to nicotinic acid adenine dinucleotide (NaAD). The conversion of NaAD to NAD...; Region: NAD_synthase; cd00553 272562003873 homodimer interface [polypeptide binding]; other site 272562003874 NAD binding pocket [chemical binding]; other site 272562003875 ATP binding pocket [chemical binding]; other site 272562003876 Mg binding site [ion binding]; other site 272562003877 active-site loop [active] 272562003878 Membrane protein implicated in regulation of membrane protease activity [Posttranslational modification, protein turnover, chaperones / Intracellular trafficking and secretion]; Region: COG1585 272562003879 prohibitin homologues; Region: PHB; smart00244 272562003880 Paraslipin or slipin-2 (SLP-2, a subgroup of the stomatin-like proteins (slipins) family; belonging to the SPFH (stomatin, prohibitin, flotillin, and HflK/C) superfamily; Region: SPFH_paraslipin; cd08829 272562003881 core domain of the SPFH (stomatin, prohibitin, flotillin, and HflK/C) superfamily; Region: SPFH_like; cl19107 272562003882 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 272562003883 This family is most closely related to the GT1 family of glycosyltransferases and named after YqgM in Bacillus licheniformis about which little is known. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to...; Region: GT1_YqgM_like; cd03801 272562003884 Arginase family; Region: Arginase; cd09989 272562003885 active site 272562003886 Mn binding site [ion binding]; other site 272562003887 oligomer interface [polypeptide binding]; other site 272562003888 Rhs family protein [Cell envelope biogenesis, outer membrane]; Region: RhsA; COG3209 272562003889 RHS repeat-associated core domain; Region: Rhs_assc_core; TIGR03696 272562003890 TPR repeat; Region: TPR_11; pfam13414 272562003891 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 272562003892 binding surface 272562003893 TPR motif; other site 272562003894 TPR repeat; Region: TPR_11; pfam13414 272562003895 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 272562003896 TPR motif; other site 272562003897 binding surface 272562003898 Tetratricopeptide repeat; Region: TPR_16; pfam13432 272562003899 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 272562003900 binding surface 272562003901 TPR motif; other site 272562003902 TPR repeat; Region: TPR_11; pfam13414 272562003903 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 272562003904 binding surface 272562003905 TPR motif; other site 272562003906 TPR repeat; Region: TPR_11; pfam13414 272562003907 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 272562003908 binding surface 272562003909 Tetratricopeptide repeat; Region: TPR_12; pfam13424 272562003910 TPR motif; other site 272562003911 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 272562003912 binding surface 272562003913 TPR repeat; Region: TPR_11; pfam13414 272562003914 TPR motif; other site 272562003915 Tetratricopeptide repeat; Region: TPR_12; pfam13424 272562003916 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 272562003917 binding surface 272562003918 TPR motif; other site 272562003919 TPR repeat; Region: TPR_11; pfam13414 272562003920 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 272562003921 binding surface 272562003922 TPR motif; other site 272562003923 HEAT repeats; Region: HEAT_2; pfam13646 272562003924 Transcriptional regulator C-terminal region; Region: TetR_C_8; pfam14278 272562003925 B12 binding domain_like associated with radical SAM domain. This domain shows similarity with B12 (adenosylcobamide) binding domains found in several enzymes, such as glutamate mutase, methionine synthase and methylmalonyl-CoA mutase, but it lacks the...; Region: radical_SAM_B12_BD; cd02068 272562003926 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 272562003927 Radical SAM superfamily; Region: Radical_SAM; pfam04055 272562003928 FeS/SAM binding site; other site 272562003929 Protein of unknown function (DUF2000); Region: DUF2000; pfam09391 272562003930 Permeases of the drug/metabolite transporter (DMT) superfamily [Carbohydrate transport and metabolism / Amino acid transport and metabolism / General function prediction only]; Region: RhaT; COG0697 272562003931 EamA-like transporter family; Region: EamA; pfam00892 272562003932 Beta-glucosidase-related glycosidases [Carbohydrate transport and metabolism]; Region: BglX; COG1472 272562003933 Glycosyl hydrolase family 3 C-terminal domain; Region: Glyco_hydro_3_C; pfam01915 272562003934 YjgF, YER057c, and UK114 belong to a large family of proteins present in bacteria, archaea, and eukaryotes with no definitive function. The conserved domain is similar in structure to chorismate mutase but there is no sequence similarity and no...; Region: YjgF_YER057c_UK114_family; cd00448 272562003935 homotrimer interaction site [polypeptide binding]; other site 272562003936 putative active site [active] 272562003937 Calcineurin-like phosphoesterase; Region: Metallophos; pfam00149 272562003938 FOG: Glucan-binding domain (YG repeat) [General function prediction only]; Region: COG5263 272562003939 FOG: Glucan-binding domain (YG repeat) [General function prediction only]; Region: COG5263 272562003940 glucan-binding repeat; Region: glucan_65_rpt; TIGR04035 272562003941 glucan-binding repeat; Region: glucan_65_rpt; TIGR04035 272562003942 glucan-binding repeat; Region: glucan_65_rpt; TIGR04035 272562003943 FOG: Glucan-binding domain (YG repeat) [General function prediction only]; Region: COG5263 272562003944 glucan-binding repeat; Region: glucan_65_rpt; TIGR04035 272562003945 FOG: Glucan-binding domain (YG repeat) [General function prediction only]; Region: COG5263 272562003946 glucan-binding repeat; Region: glucan_65_rpt; TIGR04035 272562003947 FOG: Glucan-binding domain (YG repeat) [General function prediction only]; Region: COG5263 272562003948 FOG: Glucan-binding domain (YG repeat) [General function prediction only]; Region: COG5263 272562003949 glucan-binding repeat; Region: glucan_65_rpt; TIGR04035 272562003950 FOG: Glucan-binding domain (YG repeat) [General function prediction only]; Region: COG5263 272562003951 glucan-binding repeat; Region: glucan_65_rpt; TIGR04035 272562003952 glucan-binding repeat; Region: glucan_65_rpt; TIGR04035 272562003953 FOG: Glucan-binding domain (YG repeat) [General function prediction only]; Region: COG5263 272562003954 glucan-binding repeat; Region: glucan_65_rpt; TIGR04035 272562003955 Domain of unknown function (DUF4480); Region: DUF4480; pfam13715 272562003956 Domain of unknown function (DUF4480); Region: DUF4480; pfam13715 272562003957 Uncharacterized protein conserved in bacteria (DUF2135); Region: DUF2135; cl19870 272562003958 hypothetical protein; Provisional; Region: PHA02515 272562003959 Carboxypeptidase regulatory-like domain; Region: CarboxypepD_reg; pfam13620 272562003960 Predicted membrane-bound metal-dependent hydrolases [General function prediction only]; Region: COG1988 272562003961 Beta-glucosidase/6-phospho-beta-glucosidase/beta- galactosidase [Carbohydrate transport and metabolism]; Region: BglB; COG2723 272562003962 Glycosyl hydrolase family 1; Region: Glyco_hydro_1; pfam00232 272562003963 putative alpha-glucosidase; Provisional; Region: PRK10658 272562003964 Galactose mutarotase-like; Region: Gal_mutarotas_2; pfam13802 272562003965 YicI alpha-xylosidase is a glycosyl hydrolase family 31 (GH31) enzyme that catalyzes the release of an alpha-xylosyl residue from the non-reducing end of alpha-xyloside substrates such as alpha-xylosyl fluoride and isoprimeverose. YicI forms a...; Region: GH31_xylosidase_YicI; cd06593 272562003966 active site 272562003967 homotrimer interface [polypeptide binding]; other site 272562003968 catalytic site [active] 272562003969 homohexamer (dimer of homotrimers) interface [polypeptide binding]; other site 272562003970 Transcriptional regulator/sugar kinase [Transcription / Carbohydrate transport and metabolism]; Region: NagC; COG1940 272562003971 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cd00012 272562003972 nucleotide binding site [chemical binding]; other site 272562003973 Bacterial fructose-1,6-bisphosphatase, glpX-encoded. A dimeric enzyme dependent on Mg(2+). glpX-encoded FPBase (FBPase class II) differs from other members of the inositol-phosphatase superfamily by permutation of secondary structure elements. The core...; Region: FBPase_glpX; cd01516 272562003974 putative active site [active] 272562003975 HPr kinase/phosphorylase; Provisional; Region: PRK05428 272562003976 HPr Serine kinase N terminus; Region: Hpr_kinase_N; pfam02603 272562003977 HprK/P, the bifunctional histidine-containing protein kinase/phosphatase, controls the phosphorylation state of the phosphocarrier protein HPr and regulates the utilization of carbon sources by gram-positive bacteria. It catalyzes both the ATP-dependent...; Region: HprK_C; cd01918 272562003978 Hpr binding site; other site 272562003979 active site 272562003980 homohexamer subunit interaction site [polypeptide binding]; other site 272562003981 5,10-methenyltetrahydrofolate synthetase; Region: MTHFS_bact; TIGR02727 272562003982 M18 Peptidase Aminopeptidase I; Region: M18_API; cd05659 272562003983 oligomer interface [polypeptide binding]; other site 272562003984 putative active site [active] 272562003985 metal binding site [ion binding]; metal-binding site 272562003986 Predicted metal-dependent phosphoesterases (PHP family) [General function prediction only]; Region: COG0613 272562003987 Polymerase and Histidinol Phosphatase domain of Histidinol phosphate phosphatase (HisPPase) AMP bound; Region: PHP_HisPPase_AMP; cd07438 272562003988 active site 272562003989 Predicted Co/Zn/Cd cation transporters [Inorganic ion transport and metabolism]; Region: MMT1; COG0053 272562003990 Predicted membrane protein [Function unknown]; Region: COG2733 272562003991 Protein of unknown function (DUF445); Region: DUF445; pfam04286 272562003992 Predicted membrane protein [Function unknown]; Region: COG2733 272562003993 Protein of unknown function (DUF445); Region: DUF445; pfam04286 272562003994 DNA polymerase I; Provisional; Region: PRK05755 272562003995 PIN domain of the 5'-3' exonuclease of Taq DNA polymerase I and homologs; Region: PIN_53EXO; cd09859 272562003996 active site 272562003997 metal binding site 1 [ion binding]; metal-binding site 272562003998 putative 5' ssDNA interaction site; other site 272562003999 metal binding site 3; metal-binding site 272562004000 metal binding site 2 [ion binding]; metal-binding site 272562004001 H3TH domain of the 5'-3' exonuclease of Taq DNA polymerase I and homologs; Region: H3TH_53EXO; cd09898 272562004002 putative DNA binding site [nucleotide binding]; other site 272562004003 putative metal binding site [ion binding]; other site 272562004004 inactive DEDDy 3'-5' exonuclease domain of Bacillus stearothermophilus DNA polymerase I and similar family-A DNA polymerases; Region: DNA_polA_I_Bacillus_like_exo; cd06140 272562004005 Polymerase I functions primarily to fill DNA gaps that arise during DNA repair, recombination and replication; Region: DNA_pol_A_pol_I_C; cd08637 272562004006 active site 272562004007 DNA binding site [nucleotide binding] 272562004008 catalytic site [active] 272562004009 Dephospho-CoA kinase [Coenzyme metabolism]; Region: CoaE; COG0237 272562004010 Dephospho-coenzyme A kinase (DPCK, EC 2.7.1.24) catalyzes the phosphorylation of dephosphocoenzyme A (dCoA) to yield CoA, which is the final step in CoA biosynthesis; Region: DPCK; cd02022 272562004011 CoA-binding site [chemical binding]; other site 272562004012 ATP-binding [chemical binding]; other site 272562004013 Soluble lytic murein transglycosylase and related regulatory proteins (some contain LysM/invasin domains) [Cell envelope biogenesis, outer membrane]; Region: MltE; COG0741 272562004014 Lytic Transglycosylase (LT) and Goose Egg White Lysozyme (GEWL) domain. Members include the soluble and insoluble membrane-bound LTs in bacteria, the LTs in bacteriophage lambda, as well as, the eukaryotic "goose-type" lysozymes (GEWL). LTs...; Region: LT_GEWL; cd00254 272562004015 N-acetyl-D-glucosamine binding site [chemical binding]; other site 272562004016 catalytic residue [active] 272562004017 Recombinase zinc beta ribbon domain; Region: Zn_ribbon_recom; pfam13408 272562004018 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3883 272562004019 Endo-N-acetylmuramidases (muramidases) are lysozymes (also referred to as peptidoglycan hydrolases) that degrade bacterial cell walls by catalyzing the hydrolysis of 1,4-beta-linkages between N-acetylmuramic acid and N-acetyl-D-glucosamine residues; Region: GH25_muramidase; cl10448 272562004020 Glycosyl hydrolases family 25; Region: Glyco_hydro_25; pfam01183 272562004021 active site 272562004022 Putative peptidoglycan-binding domain-containing protein [Cell envelope biogenesis, outer membrane]; Region: COG3409 272562004023 Putative peptidoglycan binding domain; Region: PG_binding_1; pfam01471 272562004024 Haemolysin XhlA; Region: XhlA; pfam10779 272562004025 Phage integrase, N-terminal SAM-like domain; Region: Phage_int_SAM_4; pfam13495 272562004026 tyrosine recombinase XerD; Region: recomb_XerD; TIGR02225 272562004027 DNA breaking-rejoining enzymes, intergrase/recombinases, C-terminal catalytic domain. The tyrosine recombinase/integrase family share the same catalytic domain containing six conserved active site residues. The best-studied members of this diverse family...; Region: INT_REC_C; cd01182 272562004028 active site 272562004029 catalytic residues [active] 272562004030 DNA binding site [nucleotide binding] 272562004031 Int/Topo IB signature motif; other site 272562004032 Chaperone of endosialidase; Region: Peptidase_S74; pfam13884 272562004033 Phage-related tail protein [Function unknown]; Region: COG5283 272562004034 phage tail tape measure protein, TP901 family, core region; Region: tape_meas_TP901; TIGR01760 272562004035 Chromosome segregation ATPases [Cell division and chromosome partitioning]; Region: Smc; COG1196 272562004036 Lytic Transglycosylase (LT) and Goose Egg White Lysozyme (GEWL) domain. Members include the soluble and insoluble membrane-bound LTs in bacteria, the LTs in bacteriophage lambda, as well as, the eukaryotic "goose-type" lysozymes (GEWL). LTs...; Region: LT_GEWL; cd00254 272562004037 N-acetyl-D-glucosamine binding site [chemical binding]; other site 272562004038 catalytic residue [active] 272562004039 Bacterial Ig-like domain; Region: Big_5; pfam13205 272562004040 Seryl-tRNA synthetase N-terminal domain; Region: Seryl_tRNA_N; pfam02403 272562004041 TolA protein; Region: tolA_full; TIGR02794 272562004042 Terminase-like family; Region: Terminase_6; pfam03237 272562004043 RNA dependent RNA polymerase; Region: RdRP; pfam05183 272562004044 Superfamily I DNA and RNA helicases [DNA replication, recombination, and repair]; Region: UvrD; COG0210 272562004045 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 272562004046 ATP binding site [chemical binding]; other site 272562004047 UvrD-like helicase C-terminal domain; Region: UvrD_C_2; pfam13538 272562004048 ATP-dependent exoDNAse (exonuclease V), alpha subunit - helicase superfamily I member [DNA replication, recombination, and repair]; Region: RecD; COG0507 272562004049 Helix-hairpin-helix containing domain; Region: HHH_4; pfam14490 272562004050 AAA domain; Region: AAA_30; pfam13604 272562004051 UvrD-like helicase C-terminal domain; Region: UvrD_C_2; pfam13538 272562004052 Domain of unknown function (DUF4121); Region: DUF4121; pfam13497 272562004053 Plasmid segregation protein ParM and similar proteins; Region: ParM_like; cd10227 272562004054 Mg binding site [ion binding]; other site 272562004055 nucleotide binding site [chemical binding]; other site 272562004056 putative protofilament interface [polypeptide binding]; other site 272562004057 Protein of unknown function DUF262; Region: DUF262; pfam03235 272562004058 Uncharacterized conserved protein [Function unknown]; Region: COG1479 272562004059 site-specific tyrosine recombinase XerC; Reviewed; Region: xerC; PRK00236 272562004060 DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213 272562004061 active site 272562004062 DNA binding site [nucleotide binding] 272562004063 Int/Topo IB signature motif; other site 272562004064 Uncharacterized conserved protein [Function unknown]; Region: COG5306 272562004065 Replication protein A, class 2b aminoacyl-tRNA synthetases, and related proteins with oligonucleotide/oligosaccharide (OB) fold; Region: RPA_2b-aaRSs_OBF_like; cl09930 272562004066 generic binding surface II; other site 272562004067 RecA-like NTPases. This family includes the NTP binding domain of F1 and V1 H+ATPases, DnaB and related helicases as well as bacterial RecA and related eukaryotic and archaeal recombinases. This group also includes bacterial conjugation proteins and...; Region: RecA-like_NTPases; cl17233 272562004068 seadornavirus VP4 protein; Region: seadorna_VP4; TIGR04235 272562004069 3D domain; Region: 3D; cl01439 272562004070 Predicted Fe-S-cluster redox enzyme [General function prediction only]; Region: COG0820 272562004071 DRE-TIM metallolyase superfamily; Region: DRE_TIM_metallolyase; cl18962 272562004072 Replicative DNA helicase [DNA replication, recombination, and repair]; Region: DnaB; COG0305 272562004073 NAD-dependent DNA ligase LigA; Validated; Region: ligA; PRK07956 272562004074 NAD+ dependent DNA ligase adenylation domain. DNA ligases catalyze the crucial step of joining the breaks in duplex DNA during DNA replication, repair and recombination, utilizing either ATP or NAD(+) as a cofactor, but using the same basic reaction...; Region: LIGANc; cd00114 272562004075 nucleotide binding pocket [chemical binding]; other site 272562004076 K-X-D-G motif; other site 272562004077 catalytic site [active] 272562004078 NAD-dependent DNA ligase OB-fold domain; Region: DNA_ligase_OB; pfam03120 272562004079 Helix-hairpin-helix domain; Region: HHH_5; pfam14520 272562004080 Helix-hairpin-helix motif; Region: HHH_2; pfam12826 272562004081 Breast Cancer Suppressor Protein (BRCA1), carboxy-terminal domain. The BRCT domain is found within many DNA damage repair and cell cycle checkpoint proteins. The unique diversity of this domain superfamily allows BRCT modules to interact forming homo...; Region: BRCT; cd00027 272562004082 Dimer interface [polypeptide binding]; other site 272562004083 BRCT sequence motif; other site 272562004084 hypothetical protein; Provisional; Region: PRK08624 272562004085 DNA primase catalytic core, N-terminal domain; Region: Toprim_N; pfam08275 272562004086 TOPRIM_DnaG_primases: The topoisomerase-primase (TORPIM) nucleotidyl transferase/hydrolase domain found in the active site regions of proteins similar to Escherichia coli DnaG. Primases synthesize RNA primers for the initiation of DNA replication. DnaG...; Region: TOPRIM_DnaG_primases; cd03364 272562004087 active site 272562004088 metal binding site [ion binding]; metal-binding site 272562004089 interdomain interaction site; other site 272562004090 single-stranded-DNA-specific exonuclease RecJ; Region: recJ; TIGR00644 272562004091 DHH family; Region: DHH; pfam01368 272562004092 DHHA1 domain; Region: DHHA1; pfam02272 272562004093 3'-phosphoadenosine 5'-phosphosulfate sulfotransferase (PAPS reductase)/FAD synthetase and related enzymes [Amino acid transport and metabolism / Coenzyme metabolism]; Region: CysH; COG0175 272562004094 This domain is found in phosphoadenosine phosphosulphate (PAPS) reductase enzymes or PAPS sulphotransferase. PAPS reductase is part of the adenine nucleotide alpha hydrolases superfamily also including N type ATP PPases and ATP sulphurylases. A highly...; Region: PAPS_reductase; cd01713 272562004095 Active Sites [active] 272562004096 GIY-YIG domain of uncharacterized hypothetical protein found in phycodnavirus PBCV-1 DNA virus, T. thermophila Tlr element eoncoding protein Tlr8p, and similar proteins found in bacteria; Region: GIY-YIG_HE_Tlr8p_PBC-V_like; cd10443 272562004097 GIY-YIG motif/motif A; other site 272562004098 putative active site [active] 272562004099 putative metal binding site [ion binding]; other site 272562004100 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4728 272562004101 anaerobic ribonucleoside triphosphate reductase; Provisional; Region: PRK07111 272562004102 ATP cone domain; Region: ATP-cone; pfam03477 272562004103 Class III ribonucleotide reductase; Region: RNR_III; cd01675 272562004104 effector binding site; other site 272562004105 active site 272562004106 Zn binding site [ion binding]; other site 272562004107 glycine loop; other site 272562004108 Trimeric dUTP diphosphatases; Region: trimeric_dUTPase; cd07557 272562004109 trimer interface [polypeptide binding]; other site 272562004110 active site 272562004111 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 272562004112 non-specific DNA binding site [nucleotide binding]; other site 272562004113 salt bridge; other site 272562004114 sequence-specific DNA binding site [nucleotide binding]; other site 272562004115 Tetratricopeptide repeat; Region: TPR_12; pfam13424 272562004116 Guanylate kinase [Nucleotide transport and metabolism]; Region: Gmk; COG0194 272562004117 active site 272562004118 5'(3')-deoxyribonucleotidase [Nucleotide transport and metabolism]; Region: COG4502 272562004119 Site-specific DNA methylase [DNA replication, recombination, and repair]; Region: Dcm; COG0270 272562004120 cofactor binding site; other site 272562004121 DNA binding site [nucleotide binding] 272562004122 substrate interaction site [chemical binding]; other site 272562004123 DNA polymerase III, alpha subunit [DNA replication, recombination, and repair]; Region: DnaE; COG0587 272562004124 Polymerase and Histidinol Phosphatase domain; Region: PHP; cl17102 272562004125 active site 272562004126 Bacterial DNA polymerase III alpha subunit; Region: DNA_pol3_alpha; pfam07733 272562004127 Helix-hairpin-helix motif; Region: HHH_6; pfam14579 272562004128 DnaE_OBF: A subfamily of OB folds corresponding to the C-terminal OB-fold nucleic acid binding domain of Thermus aquaticus and Escherichia coli type C replicative DNA polymerase III alpha subunit (DnaE). The DNA polymerase holoenzyme of E. coli contains...; Region: DnaE_OBF; cd04485 272562004129 generic binding surface II; other site 272562004130 generic binding surface I; other site 272562004131 DNA-directed RNA polymerase specialized sigma subunit [Transcription]; Region: FliA; COG1191 272562004132 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 272562004133 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cl17257 272562004134 DNA binding residues [nucleotide binding] 272562004135 Site-specific recombinases, DNA invertase Pin homologs [DNA replication, recombination, and repair]; Region: PinR; COG1961 272562004136 Serine Recombinase (SR) family, TndX-like transposase subfamily, catalytic domain; composed of large serine recombinases similar to Clostridium TndX and TnpX transposases. Serine recombinases catalyze site-specific recombination of DNA molecules by a...; Region: SR_TndX_transposase; cd03770 272562004137 putative catalytic residues [active] 272562004138 catalytic nucleophile [active] 272562004139 Recombinase; Region: Recombinase; pfam07508 272562004140 Recombinase zinc beta ribbon domain; Region: Zn_ribbon_recom; pfam13408 272562004141 Protein of unknown function (DUF3892); Region: DUF3892; pfam13031 272562004142 Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673 272562004143 Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408 272562004144 FOG: LysM repeat [Cell envelope biogenesis, outer membrane]; Region: LytE; COG1388 272562004145 Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118 272562004146 Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118 272562004147 Cell wall hydrolyses involved in spore germination [Cell envelope biogenesis, outer membrane]; Region: SleB; COG3773 272562004148 Cell Wall Hydrolase; Region: Hydrolase_2; pfam07486 272562004149 Chemotaxis signal transduction protein [Cell motility and secretion / Signal transduction mechanisms]; Region: CheW; COG0835 272562004150 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 272562004151 active site 272562004152 phosphorylation site [posttranslational modification] 272562004153 intermolecular recognition site; other site 272562004154 dimerization interface [polypeptide binding]; other site 272562004155 hypothetical protein; Provisional; Region: PRK04435 272562004156 C-terminal ACT domain of a small (; 147 a.a.) putative phenylalanine biosynthetic pathway protein described in Bacillus subtilis (BS) PheB (PheB-BS) and related domains; Region: ACT_PheB-BS; cd04888 272562004157 Homoserine kinase [Amino acid transport and metabolism]; Region: ThrB; COG0083 272562004158 GHMP kinases N terminal domain; Region: GHMP_kinases_N; pfam00288 272562004159 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl17182 272562004160 Domain of unknown function (DUF4321); Region: DUF4321; pfam14209 272562004161 Nucleotide binding protein Maf. Maf has been implicated in inhibition of septum formation in eukaryotes, bacteria and archaea, but homologs in B.subtilis and S.cerevisiae are nonessential for cell division. Maf has been predicted to be a nucleotide- or...; Region: Maf; cd00555 272562004162 active site 272562004163 dimer interface [polypeptide binding]; other site 272562004164 hypothetical protein; Reviewed; Region: PRK00024 272562004165 Mov34/MPN/PAD-1 family; Region: MPN_DUF2466; cd08071 272562004166 MPN+ (JAMM) motif; other site 272562004167 Zinc-binding site [ion binding]; other site 272562004168 rod shape-determining protein MreB; Provisional; Region: PRK13927 272562004169 MreB and similar proteins; Region: MreB_like; cd10225 272562004170 nucleotide binding site [chemical binding]; other site 272562004171 Mg binding site [ion binding]; other site 272562004172 putative protofilament interaction site [polypeptide binding]; other site 272562004173 RodZ interaction site [polypeptide binding]; other site 272562004174 Cell shape-determining protein [Cell envelope biogenesis, outer membrane]; Region: MreC; COG1792 272562004175 rod shape-determining protein MreD; Region: MreD; pfam04093 272562004176 penicillin-binding protein 2; Region: pbp2_mrdA; TIGR03423 272562004177 Penicillin-binding Protein dimerization domain; Region: PBP_dimer; pfam03717 272562004178 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; cl17760 272562004179 penicillin-binding protein 2; Region: pbp2_mrdA; TIGR03423 272562004180 Penicillin-binding Protein dimerization domain; Region: PBP_dimer; pfam03717 272562004181 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; cl17760 272562004182 penicillin-binding protein 2; Region: pbp2_mrdA; TIGR03423 272562004183 Penicillin-binding Protein dimerization domain; Region: PBP_dimer; pfam03717 272562004184 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; cl17760 272562004185 septum formation inhibitor; Reviewed; Region: minC; PRK00513 272562004186 Septum formation inhibitor MinC, C-terminal domain; Region: MinC_C; pfam03775 272562004187 septum site-determining protein MinD; Region: minD_bact; TIGR01968 272562004188 Bacterial cell division requires the formation of a septum at mid-cell. The site is determined by the min operon products MinC, MinD and MinE. MinC is a nonspecific inhibitor of the septum protein FtsZ. MinE is the supressor of MinC. MinD plays a pivotal...; Region: MinD; cd02036 272562004189 P-loop; other site 272562004190 ADP binding residues [chemical binding]; other site 272562004191 Switch I; other site 272562004192 Switch II; other site 272562004193 rod shape-determining protein RodA; Region: rodA_shape; TIGR02210 272562004194 Membrane proteins related to metalloendopeptidases [Cell envelope biogenesis, outer membrane]; Region: NlpD; COG0739 272562004195 Peptidase family M23; Region: Peptidase_M23; pfam01551 272562004196 SpoIVFB Site-2 protease (S2P), a zinc metalloprotease (MEROPS family M50B), regulates intramembrane proteolysis (RIP), and is involved in the pro-sigmaK pathway of bacterial spore formation. SpoIVFB (sporulation protein, stage IV cell wall formation, F...; Region: S2P-M50_SpoIVFB; cd06161 272562004197 Peptidase family M50; Region: Peptidase_M50; pfam02163 272562004198 active site 272562004199 putative substrate binding region [chemical binding]; other site 272562004200 The CBS domain, named after human CBS, is a small domain originally identified in cystathionine beta-synthase and is subsequently found in a wide range of different proteins. CBS domains usually occur in tandem repeats. They associate to form a so-called...; Region: CBS_pair; cl15354 272562004201 radical SAM family uncharacterized protein; Region: rSAM_fuse_unch; TIGR03960 272562004202 B12 binding domain (B12-BD). Most of the members bind different cobalamid derivates, like B12 (adenosylcobamide) or methylcobalamin or methyl-Co(III) 5-hydroxybenzimidazolylcobamide. This domain is found in several enzymes, such as glutamate mutase; Region: B12-binding_like; cl00293 272562004203 B12 binding site [chemical binding]; other site 272562004204 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 272562004205 FeS/SAM binding site; other site 272562004206 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG5011 272562004207 Uncharacterized protein conserved in bacteria (DUF2344); Region: DUF2344; pfam10105 272562004208 Ribonucleases G and E [Translation, ribosomal structure and biogenesis]; Region: CafA; COG1530 272562004209 S1_RNase_E: RNase E and RNase G, S1-like RNA-binding domain. RNase E is an essential endoribonuclease in the processing and degradation of RNA. In addition to its role in mRNA degradation, RNase E has also been implicated in the processing of rRNA, and...; Region: S1_RNase_E; cd04453 272562004210 homodimer interface [polypeptide binding]; other site 272562004211 oligonucleotide binding site [chemical binding]; other site 272562004212 Ribonuclease E/G family; Region: RNase_E_G; pfam10150 272562004213 50S ribosomal protein L21; Validated; Region: rplU; PRK05573 272562004214 Predicted ribosomal protein [Translation, ribosomal structure and biogenesis]; Region: COG2868 272562004215 50S ribosomal protein L27; Validated; Region: rpmA; PRK05435 272562004216 GTPase CgtA; Reviewed; Region: obgE; PRK12297 272562004217 GTP1/OBG; Region: GTP1_OBG; pfam01018 272562004218 Obg GTPase; Region: Obg; cd01898 272562004219 G1 box; other site 272562004220 GTP/Mg2+ binding site [chemical binding]; other site 272562004221 Switch I region; other site 272562004222 G2 box; other site 272562004223 G3 box; other site 272562004224 Switch II region; other site 272562004225 G4 box; other site 272562004226 G5 box; other site 272562004227 Domain of unknown function (DUF1967); Region: DUF1967; pfam09269 272562004228 Predicted RNA-binding protein containing KH domain, possibly ribosomal protein [Translation, ribosomal structure and biogenesis]; Region: COG1534 272562004229 Nicotinamide/nicotinate mononucleotide adenylyltransferase; Region: NMNAT; cd02165 272562004230 active site 272562004231 (T/H)XGH motif; other site 272562004232 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 272562004233 Zn2+ binding site [ion binding]; other site 272562004234 Mg2+ binding site [ion binding]; other site 272562004235 Transcriptional regulator [Transcription]; Region: LytR; COG1316 272562004236 LytR cell envelope-related transcriptional attenuator; Region: LytR_C; pfam13399 272562004237 YjgF, YER057c, and UK114 belong to a large family of proteins present in bacteria, archaea, and eukaryotes with no definitive function. The conserved domain is similar in structure to chorismate mutase but there is no sequence similarity and no...; Region: YjgF_YER057c_UK114_family; cd00448 272562004238 homotrimer interaction site [polypeptide binding]; other site 272562004239 putative active site [active] 272562004240 Pseudouridylate synthases, 23S RNA-specific [Translation, ribosomal structure and biogenesis]; Region: RluA; COG0564 272562004241 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 272562004242 RNA binding surface [nucleotide binding]; other site 272562004243 Pseudouridine synthase, RsuA/RluD family; Region: PseudoU_synth_RluCD_like; cd02869 272562004244 active site 272562004245 D-alanyl-D-alanine carboxypeptidase [Cell envelope biogenesis, outer membrane]; Region: DacC; COG1686 272562004246 Beta-lactamase enzyme family; Region: Beta-lactamase2; cl19191 272562004247 Penicillin-binding protein 5, C-terminal domain; Region: PBP5_C; pfam07943 272562004248 DNA uptake protein and related DNA-binding proteins [DNA replication, recombination, and repair]; Region: ComEA; COG1555 272562004249 SLBB domain; Region: SLBB; pfam10531 272562004250 Helix-hairpin-helix motif; Region: HHH_3; pfam12836 272562004251 Cation transporter/ATPase, N-terminus; Region: Cation_ATPase_N; smart00831 272562004252 Cation transport ATPase [Inorganic ion transport and metabolism]; Region: MgtA; COG0474 272562004253 E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122 272562004254 Putative hydrolase of sodium-potassium ATPase alpha subunit; Region: Hydrolase_like2; pfam13246 272562004255 DNA polymerase III subunit delta; Reviewed; Region: holA; PRK05574 272562004256 DNA polymerase III, delta subunit; Region: DNA_pol3_delta; pfam06144 272562004257 30S ribosomal protein S20; Reviewed; Region: rpsT; PRK00239 272562004258 GPR endopeptidase; Region: GPR; TIGR01441 272562004259 Stage II sporulation protein P (SpoIIP); Region: SpoIIP; pfam07454 272562004260 stage II sporulation protein P; Region: spore_II_P; TIGR02867 272562004261 GTP-binding protein LepA; Provisional; Region: PRK05433 272562004262 LepA also known as Elongation Factor 4 (EF4); Region: LepA; cd01890 272562004263 G1 box; other site 272562004264 putative GEF interaction site [polypeptide binding]; other site 272562004265 GTP/Mg2+ binding site [chemical binding]; other site 272562004266 Switch I region; other site 272562004267 G2 box; other site 272562004268 G3 box; other site 272562004269 Switch II region; other site 272562004270 G4 box; other site 272562004271 G5 box; other site 272562004272 lepA_II: This subfamily represents the domain II of LepA, a GTP-binding protein localized in the cytoplasmic membrane. The N-terminal domain of LepA shares regions of homology to translation factors. In terms of interaction with the ribosome, EF-G, EF-Tu...; Region: lepA_II; cd03699 272562004273 Elongation Factor G, domain II; Region: EFG_II; pfam14492 272562004274 lepA_C: This family represents the C-terminal region of LepA, a GTP-binding protein localized in the cytoplasmic membrane. LepA is ubiquitous in Bacteria and Eukaryota (e.g. Saccharomyces cerevisiae GUF1p), but is missing from Archaea. LepA exhibits...; Region: lepA_C; cd03709 272562004275 GTP-binding protein LepA C-terminus; Region: LepA_C; pfam06421 272562004276 coproporphyrinogen III oxidase; Provisional; Region: PRK05799 272562004277 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 272562004278 FeS/SAM binding site; other site 272562004279 HemN C-terminal domain; Region: HemN_C; pfam06969 272562004280 heat shock gene repressor HrcA; Region: hrcA; TIGR00331 272562004281 Winged helix-turn-helix transcription repressor, HrcA DNA-binding; Region: HrcA_DNA-bdg; pfam03444 272562004282 HrcA protein C terminal domain; Region: HrcA; pfam01628 272562004283 GrpE is the adenine nucleotide exchange factor of DnaK (Hsp70)-type ATPases. The GrpE dimer binds to the ATPase domain of Hsp70 catalyzing the dissociation of ADP, which enables rebinding of ATP, one step in the Hsp70 reaction cycle in protein folding; Region: GrpE; cd00446 272562004284 dimer interface [polypeptide binding]; other site 272562004285 hsp70 (ATPase domain) interactions [polypeptide binding]; other site 272562004286 molecular chaperone DnaK; Provisional; Region: dnaK; PRK00290 272562004287 Nucleotide-binding domain of human HSPA9 and similar proteins; Region: HSPA9-Ssq1-like_NBD; cd10234 272562004288 nucleotide binding site [chemical binding]; other site 272562004289 NEF interaction site [polypeptide binding]; other site 272562004290 SBD interface [polypeptide binding]; other site 272562004291 chaperone protein DnaJ; Provisional; Region: PRK14297 272562004292 DnaJ domain or J-domain. DnaJ/Hsp40 (heat shock protein 40) proteins are highly conserved and play crucial roles in protein translation, folding, unfolding, translocation, and degradation. They act primarily by stimulating the ATPase activity of Hsp70s; Region: DnaJ; cd06257 272562004293 HSP70 interaction site [polypeptide binding]; other site 272562004294 C-terminal substrate binding domain of DnaJ and HSP40; Region: DnaJ_C; cd10747 272562004295 substrate binding site [polypeptide binding]; other site 272562004296 Zinc finger domain of DnaJ and HSP40; Region: DnaJ_zf; cd10719 272562004297 Zn binding sites [ion binding]; other site 272562004298 dimer interface [polypeptide binding]; other site 272562004299 Ribosomal protein L11 methyltransferase (PrmA); Region: PrmA; pfam06325 272562004300 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 272562004301 S-adenosylmethionine binding site [chemical binding]; other site 272562004302 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG1385 272562004303 2-methylthioadenine synthetase [Translation, ribosomal structure and biogenesis]; Region: MiaB; COG0621 272562004304 Uncharacterized protein family UPF0004; Region: UPF0004; pfam00919 272562004305 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 272562004306 FeS/SAM binding site; other site 272562004307 Protein Kinase C Interacting protein related (PKCI): PKCI and related proteins belong to the ubiquitous HIT family of hydrolases that act on alpha-phosphates of ribonucleotides. The members of this subgroup have a conserved HxHxHxx motif (x is a...; Region: PKCI_related; cd01276 272562004308 nucleotide binding site/active site [active] 272562004309 HIT family signature motif; other site 272562004310 catalytic residue [active] 272562004311 30S ribosomal protein S21; Reviewed; Region: rpsU; PRK00270 272562004312 Yqey-like protein; Region: YqeY; pfam09424 272562004313 sporulation protein YqfC; Region: spore_yqfC; TIGR02856 272562004314 Putative stage IV sporulation protein YqfD; Region: YqfD; pfam06898 272562004315 sporulation protein YqfD; Region: spore_yqfD; TIGR02876 272562004316 Predicted membrane-associated HD superfamily hydrolase [General function prediction only]; Region: COG1480 272562004317 7TM-HD extracellular; Region: 7TMR-HDED; pfam07697 272562004318 7TM receptor with intracellular HD hydrolase; Region: 7TM-7TMR_HD; pfam07698 272562004319 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 272562004320 Zn2+ binding site [ion binding]; other site 272562004321 Mg2+ binding site [ion binding]; other site 272562004322 metal-binding heat shock protein; Provisional; Region: PRK00016 272562004323 Integral membrane undecaprenol kinase domain co-occurring with type 2 phosphatidic acid phosphatase-like domains; Region: UDPK_IM_PAP2_like; cd14266 272562004324 trimer interface [polypeptide binding]; other site 272562004325 putative active site [active] 272562004326 Zn binding site [ion binding]; other site 272562004327 PAP2_like proteins, diacylglycerol_kinase like sub-family. In some prokaryotes, PAP2_like phosphatase domains appear fused to E. coli DAGK-like trans-membrane diacylglycerol kinase domains. The cellular function of these architectures remains to be...; Region: PAP2_diacylglycerolkinase; cd03383 272562004328 Membrane-associated phospholipid phosphatase [Lipid metabolism]; Region: PgpB; COG0671 272562004329 active site 272562004330 GTPase Era; Reviewed; Region: era; PRK00089 272562004331 E. coli Ras-like protein (Era) is a multifunctional GTPase; Region: Era; cd04163 272562004332 G1 box; other site 272562004333 GTP/Mg2+ binding site [chemical binding]; other site 272562004334 Switch I region; other site 272562004335 G2 box; other site 272562004336 Switch II region; other site 272562004337 G3 box; other site 272562004338 G4 box; other site 272562004339 G5 box; other site 272562004340 KH domain; Region: KH_2; pfam07650 272562004341 DNA repair protein RecO; Region: reco; TIGR00613 272562004342 Recombination protein O N terminal; Region: RecO_N; pfam11967 272562004343 Recombination protein O C terminal; Region: RecO_C; pfam02565 272562004344 SIS domain. SIS (Sugar ISomerase) domains are found in many phosphosugar isomerases and phosphosugar binding proteins. SIS domains are also found in proteins that regulate the expression of genes involved in synthesis of phosphosugars; Region: SIS; cl00389 272562004345 Domain of unknown function (DUF4342); Region: DUF4342; pfam14242 272562004346 Aminoglycoside 3'-phosphotransferase (APH) and Choline Kinase (ChoK) family. The APH/ChoK family is part of a larger superfamily that includes the catalytic domains of other kinases, such as the typical serine/threonine/tyrosine protein kinases (PKs)...; Region: APH_ChoK_like; cl17270 272562004347 Phosphotransferase enzyme family; Region: APH; pfam01636 272562004348 substrate binding site [chemical binding]; other site 272562004349 DNA primase; Validated; Region: dnaG; PRK05667 272562004350 CHC2 zinc finger; Region: zf-CHC2; pfam01807 272562004351 DNA primase catalytic core, N-terminal domain; Region: Toprim_N; pfam08275 272562004352 TOPRIM_DnaG_primases: The topoisomerase-primase (TORPIM) nucleotidyl transferase/hydrolase domain found in the active site regions of proteins similar to Escherichia coli DnaG. Primases synthesize RNA primers for the initiation of DNA replication. DnaG...; Region: TOPRIM_DnaG_primases; cd03364 272562004353 active site 272562004354 metal binding site [ion binding]; metal-binding site 272562004355 interdomain interaction site; other site 272562004356 DnaB-helicase binding domain of primase; Region: DnaB_bind; pfam10410 272562004357 RNA polymerase sigma factor RpoD; Validated; Region: PRK09210 272562004358 Sigma-70 factor, region 1.1; Region: Sigma70_r1_1; pfam03979 272562004359 Sigma-70 factor, region 1.2; Region: Sigma70_r1_2; pfam00140 272562004360 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 272562004361 Sigma-70 region 3; Region: Sigma70_r3; pfam04539 272562004362 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 272562004363 DNA binding residues [nucleotide binding] 272562004364 Bacterial PH domain; Region: bPH_5; pfam10882 272562004365 Predicted SAM-dependent methyltransferase [General function prediction only]; Region: COG2384 272562004366 NIF3 (NGG1p interacting factor 3); Region: NIF3; pfam01784 272562004367 Zn-ribbon protein, possibly nucleic acid-binding [General function prediction only]; Region: COG1579 272562004368 Putative zinc ribbon domain; Region: DUF164; pfam02591 272562004369 Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805 272562004370 Pentapeptide repeats (9 copies); Region: Pentapeptide_4; pfam13599 272562004371 Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805 272562004372 Pentapeptide repeats (9 copies); Region: Pentapeptide_4; pfam13599 272562004373 Protein of unknown function (DUF3467); Region: DUF3467; pfam11950 272562004374 Putative peptidoglycan-binding domain-containing protein [Cell envelope biogenesis, outer membrane]; Region: COG3409 272562004375 Putative peptidoglycan binding domain; Region: PG_binding_1; pfam01471 272562004376 Ion transport protein; Region: Ion_trans; pfam00520 272562004377 Ion channel; Region: Ion_trans_2; pfam07885 272562004378 Pleckstrin homology-like domain; Region: PH-like; cl17171 272562004379 Glycerol uptake facilitator and related permeases (Major Intrinsic Protein Family) [Carbohydrate transport and metabolism]; Region: GlpF; COG0580 272562004380 amphipathic channel; other site 272562004381 Asn-Pro-Ala signature motifs; other site 272562004382 Glycerol-3-phosphate responsive antiterminator (mRNA-binding) [Transcription]; Region: GlpP; COG1954 272562004383 glycerol kinase; Provisional; Region: glpK; PRK00047 272562004384 Escherichia coli glycerol kinase-like proteins; belongs to the FGGY family of carbohydrate kinases; Region: FGGY_EcGK_like; cd07786 272562004385 N- and C-terminal domain interface [polypeptide binding]; other site 272562004386 active site 272562004387 MgATP binding site [chemical binding]; other site 272562004388 catalytic site [active] 272562004389 metal binding site [ion binding]; metal-binding site 272562004390 glycerol binding site [chemical binding]; other site 272562004391 homotetramer interface [polypeptide binding]; other site 272562004392 homodimer interface [polypeptide binding]; other site 272562004393 FBP binding site [chemical binding]; other site 272562004394 protein IIAGlc interface [polypeptide binding]; other site 272562004395 Predicted dehydrogenase [General function prediction only]; Region: COG0579 272562004396 hydroxyglutarate oxidase; Provisional; Region: PRK11728; cl19156 272562004397 BFD-like [2Fe-2S] binding domain; Region: Fer2_BFD; pfam04324 272562004398 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl19134 272562004399 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox_2; pfam07992 272562004400 Uncharacterized protein with conserved CXXC pairs [Function unknown]; Region: COG3862 272562004401 Uncharacterized conserved protein [Function unknown]; Region: COG1284 272562004402 Uncharacterized BCR, YitT family COG1284; Region: DUF161; pfam02588 272562004403 Uncharacterized BCR, YitT family COG1284; Region: DUF161; pfam02588 272562004404 Uncharacterized protein conserved in bacteria (DUF2179); Region: DUF2179; pfam10035 272562004405 putative iron-only hydrogenase system regulator; Region: hyd_TM1266; TIGR03959 272562004406 Spo0E like sporulation regulatory protein; Region: SpoOE-like; pfam09388 272562004407 Phosphopantetheinyl transferase [Coenzyme metabolism]; Region: Sfp; COG2091 272562004408 4'-phosphopantetheinyl transferase superfamily; Region: ACPS; pfam01648 272562004409 Metal-dependent hydrolases of the beta-lactamase superfamily III [General function prediction only]; Region: ElaC; COG1234 272562004410 D-mannonate oxidoreductase; Provisional; Region: PRK08277 272562004411 putative D-mannonate oxidoreductase, classical (c) SDR; Region: mannonate_red_SDR_c; cd08935 272562004412 putative NAD(P) binding site [chemical binding]; other site 272562004413 active site 272562004414 mannonate dehydratase; Provisional; Region: PRK03906 272562004415 D-mannonate dehydratase [Carbohydrate transport and metabolism]; Region: UxuA; COG1312 272562004416 AraC-like ligand binding domain; Region: AraC_binding; pfam02311 272562004417 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 272562004418 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 272562004419 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 272562004420 Radical SAM superfamily; Region: Radical_SAM; pfam04055 272562004421 FeS/SAM binding site; other site 272562004422 Iron-sulfur cluster-binding domain; Region: SPASM; pfam13186 272562004423 Spore coat protein [Cell envelope biogenesis, outer membrane]; Region: COG5577 272562004424 Spore coat associated protein JA (CotJA); Region: CotJA; pfam11007 272562004425 CotJB protein; Region: CotJB; pfam12652 272562004426 Manganese catalase, ferritin-like diiron-binding domain; Region: Mn_catalase; cd01051 272562004427 dimanganese center [ion binding]; other site 272562004428 D-xylose transporter XylE; Provisional; Region: xylE; PRK10077 272562004429 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 272562004430 putative substrate translocation pore; other site 272562004431 Transcriptional regulators [Transcription]; Region: PhnF; COG2188 272562004432 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 272562004433 DNA-binding site [nucleotide binding]; DNA binding site 272562004434 Transcriptional regulators [Transcription]; Region: PurR; COG1609 272562004435 Ligand-binding domain of DNA transcription repressor specific for arabinose (AraR) which is a member of the LacI-GalR family of bacterial transcription regulators; Region: PBP1_AraR; cd01541 272562004436 putative dimerization interface [polypeptide binding]; other site 272562004437 putative ligand binding site [chemical binding]; other site 272562004438 Class II Aldolase and Adducin head (N-terminal) domain. Aldolases are ubiquitous enzymes catalyzing central steps of carbohydrate metabolism. Based on enzymatic mechanisms, this superfamily has been divided into two distinct classes (Class I and II); Region: Aldolase_II; cd00398 272562004439 intersubunit interface [polypeptide binding]; other site 272562004440 active site 272562004441 Zn2+ binding site [ion binding]; other site 272562004442 L-arabinose isomerase; Provisional; Region: PRK02929 272562004443 L-fucose isomerase (FucIase) and L-arabinose isomerase (AI) family; composed of FucIase, AI and similar proteins. FucIase converts L-fucose, an aldohexose, to its ketose form, which prepares it for aldol cleavage (similar to the isomerization of glucose...; Region: L-fuc_L-ara-isomerases; cl00947 272562004444 hexamer (dimer of trimers) interface [polypeptide binding]; other site 272562004445 trimer interface [polypeptide binding]; other site 272562004446 substrate binding site [chemical binding]; other site 272562004447 Mn binding site [ion binding]; other site 272562004448 putative phosphoketolase; Provisional; Region: PRK05261 272562004449 Thiamine pyrophosphate (TPP) family, Phosphoketolase (PK) subfamily, TPP-binding module; PK catalyzes the conversion of D-xylulose 5-phosphate and phosphate to acetyl phosphate, D-glyceraldehyde-3-phosphate and H2O. This enzyme requires divalent...; Region: TPP_PK; cd02011 272562004450 TPP-binding site; other site 272562004451 D-xylulose 5-phosphate/D-fructose 6-phosphate phosphoketolase; Region: XFP; pfam03894 272562004452 XFP C-terminal domain; Region: XFP_C; pfam09363 272562004453 L-ribulokinase-like proteins; a subfamily of the FGGY family of carbohydrate kinases; Region: FGGY_L-RBK_like; cd07778 272562004454 Sugar (pentulose and hexulose) kinases [Carbohydrate transport and metabolism]; Region: XylB; COG1070 272562004455 putative N- and C-terminal domain interface [polypeptide binding]; other site 272562004456 putative active site [active] 272562004457 MgATP binding site [chemical binding]; other site 272562004458 catalytic site [active] 272562004459 metal binding site [ion binding]; metal-binding site 272562004460 putative carbohydrate binding site [chemical binding]; other site 272562004461 Sugar (and other) transporter; Region: Sugar_tr; pfam00083 272562004462 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 272562004463 putative substrate translocation pore; other site 272562004464 L-arabinose isomerase; Provisional; Region: PRK02929 272562004465 L-Arabinose isomerase (AI) catalyzes the isomerization of L-arabinose to L-ribulose, the first reaction in its conversion into D-xylulose-5-phosphate, an intermediate in the pentose phosphate pathway, which allows L-arabinose to be used as a carbon...; Region: L-arabinose_isomerase; cd03557 272562004466 putative hexamer (dimer of trimers) interface [polypeptide binding]; other site 272562004467 trimer interface [polypeptide binding]; other site 272562004468 putative substrate binding site [chemical binding]; other site 272562004469 putative metal binding site [ion binding]; other site 272562004470 Transaldolase-like fructose-6-phosphate aldolases (FSA) found in bacteria and archaea; Region: Transaldolase_FSA; cd00956 272562004471 active site 272562004472 intersubunit interactions; other site 272562004473 catalytic residue [active] 272562004474 Transketolase [Carbohydrate transport and metabolism]; Region: TktA; COG0021 272562004475 Thiamine pyrophosphate (TPP) family, Transketolase (TK) subfamily, TPP-binding module; TK catalyzes the transfer of a two-carbon unit from ketose phosphates to aldose phosphates. In heterotrophic organisms, TK provides a link between glycolysis and the...; Region: TPP_TK; cd02012 272562004476 TPP-binding site [chemical binding]; other site 272562004477 dimer interface [polypeptide binding]; other site 272562004478 Pyrimidine (PYR) binding domain of 1-deoxy-D-xylulose-5-phosphate synthase (DXS), transketolase (TK), and related proteins; Region: TPP_PYR_DXS_TK_like; cd07033 272562004479 PYR/PP interface [polypeptide binding]; other site 272562004480 dimer interface [polypeptide binding]; other site 272562004481 TPP binding site [chemical binding]; other site 272562004482 Transketolase, C-terminal domain; Region: Transketolase_C; pfam02780 272562004483 galactose mutarotase_like; Region: galactose_mutarotase_like; cd09019 272562004484 active site 272562004485 catalytic residues [active] 272562004486 ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: RbsB; COG1879 272562004487 Periplasmic binding proteins specific to rhizopines; Region: PBP1_rhizopine_binding_like; cd06301 272562004488 putative ligand binding site [chemical binding]; other site 272562004489 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 272562004490 dimerization interface [polypeptide binding]; other site 272562004491 Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer); Region: MA; smart00283 272562004492 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cl19050 272562004493 dimer interface [polypeptide binding]; other site 272562004494 putative CheW interface [polypeptide binding]; other site 272562004495 Phosphotransferase system IIC components, glucose/maltose/N-acetylglucosamine-specific [Carbohydrate transport and metabolism]; Region: PtsG; COG1263 272562004496 PTS system, N-acetylglucosamine-specific IIBC component; Region: PTS-II-BC-nag; TIGR01998 272562004497 PTS_IIB, PTS system, glucose/sucrose specific IIB subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIB_glc; cd00212 272562004498 active site turn [active] 272562004499 phosphorylation site [posttranslational modification] 272562004500 Phosphotransferase system IIA components [Carbohydrate transport and metabolism]; Region: NagE; COG2190 272562004501 HPr interaction site; other site 272562004502 glycerol kinase (GK) interaction site [polypeptide binding]; other site 272562004503 active site 272562004504 phosphorylation site [posttranslational modification] 272562004505 transcriptional antiterminator BglG; Provisional; Region: PRK09772 272562004506 CAT RNA binding domain; Region: CAT_RBD; smart01061 272562004507 PRD domain; Region: PRD; pfam00874 272562004508 PRD domain; Region: PRD; pfam00874 272562004509 [FeFe] hydrogenase H-cluster radical SAM maturase HydG; Region: rSAM_HydG; TIGR03955 272562004510 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 272562004511 FeS/SAM binding site; other site 272562004512 Biotin and Thiamin Synthesis associated domain; Region: BATS; smart00876 272562004513 Predicted xylanase/chitin deacetylase [Carbohydrate transport and metabolism]; Region: CDA1; COG0726 272562004514 Catalytic NodB homology domain of Streptococcus mutans polysaccharide deacetylase PgdA, Bacillus subtilis YheN, and similar proteins; Region: CE4_SmPgdA_like; cd10944 272562004515 NodB motif; other site 272562004516 active site 272562004517 catalytic site [active] 272562004518 Zn binding site [ion binding]; other site 272562004519 Uncharacterized conserved protein [General function prediction only]; Region: BioY; COG1268 272562004520 Dethiobiotin synthetase [Coenzyme metabolism]; Region: BioD; COG0132 272562004521 AAA domain; Region: AAA_26; pfam13500 272562004522 Adenosylmethionine-8-amino-7-oxononanoate aminotransferase [Coenzyme metabolism]; Region: BioA; COG0161 272562004523 Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610 272562004524 inhibitor-cofactor binding pocket; inhibition site 272562004525 pyridoxal 5'-phosphate binding site [chemical binding]; other site 272562004526 catalytic residue [active] 272562004527 Copper/zinc superoxide dismutase (SOD). superoxide dismutases catalyse the conversion of superoxide radicals to molecular oxygen. Three evolutionarily distinct families of SODs are known, of which the copper/zinc-binding family is one. Defects in the...; Region: Cu-Zn_Superoxide_Dismutase; cd00305 272562004528 E-class dimer interface [polypeptide binding]; other site 272562004529 P-class dimer interface [polypeptide binding]; other site 272562004530 active site 272562004531 Cu2+ binding site [ion binding]; other site 272562004532 Zn2+ binding site [ion binding]; other site 272562004533 Catalytic domain of EDTA-resistant nuclease Nuc from Salmonella typhimurium and similar proteins; Region: PLDc_Nuc; cd09170 272562004534 PLD-like domain; Region: PLDc_2; pfam13091 272562004535 putative active site [active] 272562004536 catalytic site [active] 272562004537 cobalt transport protein CbiM; Validated; Region: PRK08319 272562004538 cobalt ABC transporter, permease protein CbiQ; Region: CbiQ_TIGR; TIGR02454 272562004539 cobalt transporter ATP-binding subunit; Provisional; Region: cbiO; PRK13639 272562004540 First domain of the ATP-binding cassette component of cobalt transport system; Region: ABC_cobalt_CbiO_domain1; cd03225 272562004541 Walker A/P-loop; other site 272562004542 ATP binding site [chemical binding]; other site 272562004543 Q-loop/lid; other site 272562004544 ABC transporter signature motif; other site 272562004545 Walker B; other site 272562004546 D-loop; other site 272562004547 H-loop/switch region; other site 272562004548 Histidinol-phosphate/aromatic aminotransferase and cobyric acid decarboxylase [Amino acid transport and metabolism]; Region: HisC; COG0079 272562004549 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 272562004550 pyridoxal 5'-phosphate binding site [chemical binding]; other site 272562004551 homodimer interface [polypeptide binding]; other site 272562004552 catalytic residue [active] 272562004553 cobalamin biosynthesis protein CbiG; Validated; Region: PRK05788 272562004554 Cobalamin synthesis G N-terminal; Region: CbiG_N; pfam11760 272562004555 Cobalamin biosynthesis central region; Region: CbiG_mid; pfam11761 272562004556 Cobalamin synthesis G C-terminus; Region: CbiG_C; pfam01890 272562004557 Protein involved in propanediol utilization, and related proteins (includes coumermycin biosynthetic protein), possible kinase [Secondary metabolites biosynthesis, transport, and catabolism]; Region: PduX; COG4542 272562004558 GHMP kinases N terminal domain; Region: GHMP_kinases_N; pfam00288 272562004559 Nicotinate-nucleotide-dimethylbenzimidazole phosphoribosyltransferase (DMB-PRT), also called CobT; Region: DMB-PRT_CobT; cd02439 272562004560 putative dimer interface [polypeptide binding]; other site 272562004561 active site pocket [active] 272562004562 putative cataytic base [active] 272562004563 Cobalamin biosynthesis protein CbiK, Co2+ chelatase [Coenzyme metabolism]; Region: CbiK; COG4822 272562004564 Anaerobic cobalamin biosynthetic cobalt chelatase (CbiK), N-terminal domain. CbiK is part of the cobalt-early path for cobalamin biosynthesis. It catalyzes the insertion of cobalt into the oxidized form of precorrin-2, factor II (sirohydrochlorin), the...; Region: CbiK_N; cd03412 272562004565 active site 272562004566 C-terminal domain interface [polypeptide binding]; other site 272562004567 Anaerobic cobalamin biosynthetic cobalt chelatase (CbiK), C-terminal domain. CbiK is part of the cobalt-early path for cobalamin biosynthesis. It catalyzes the insertion of cobalt into the oxidized form of precorrin-2, factor II (sirohydrochlorin), the...; Region: CbiK_C; cd03413 272562004568 active site 272562004569 N-terminal domain interface [polypeptide binding]; other site 272562004570 cobyric acid synthase; Provisional; Region: PRK00784 272562004571 The Fer4_NifH superfamily contains a variety of proteins which share a common ATP-binding domain. Functionally, proteins in this superfamily use the energy from hydrolysis of NTP to transfer electron or ion; Region: Fer4_NifH; cl17203 272562004572 Type 1 glutamine amidotransferase (GATase1) domain found in Cobyric Acid Synthase (CobQ); Region: GATase1_CobQ; cd01750 272562004573 catalytic triad [active] 272562004574 The Fer4_NifH superfamily contains a variety of proteins which share a common ATP-binding domain. Functionally, proteins in this superfamily use the energy from hydrolysis of NTP to transfer electron or ion; Region: Fer4_NifH; cl17203 272562004575 Cobyrinic acid a,c-diamide synthase [Coenzyme metabolism]; Region: CobB; COG1797 272562004576 Type 1 glutamine amidotransferase (GATase1) domain found in Cobyrinic Acid a,c-Diamide Synthase; Region: GATase1_CobB; cd03130 272562004577 catalytic triad [active] 272562004578 precorrin-8X methylmutase; Validated; Region: cbiC; PRK05575 272562004579 Cobalamin biosynthesis protein CbiD [Coenzyme metabolism]; Region: CbiD; COG1903 272562004580 Methyltransferase domain; Region: Methyltransf_31; pfam13847 272562004581 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 272562004582 S-adenosylmethionine binding site [chemical binding]; other site 272562004583 Precorrin-2 C20-methyltransferase, also named CobI or CbiL; Region: Precorrin_2_C20_MT; cd11645 272562004584 active site 272562004585 SAM binding site [chemical binding]; other site 272562004586 homodimer interface [polypeptide binding]; other site 272562004587 Precorrin-4 C11-methyltransferase (CbiF/CobM); Region: Precorrin-4_C11-MT; cd11641 272562004588 active site 272562004589 SAM binding site [chemical binding]; other site 272562004590 homodimer interface [polypeptide binding]; other site 272562004591 Precorrin-6x reductase [Coenzyme metabolism]; Region: CobK; COG2099 272562004592 Precorrin-3B C(17)-methyltransferase (CobJ/CbiH); Region: Precorrin_3B_C17_MT; cd11646 272562004593 active site 272562004594 SAM binding site [chemical binding]; other site 272562004595 homodimer interface [polypeptide binding]; other site 272562004596 Adenosylcobinamide kinase / adenosylcobinamide phosphate guanyltransferase (CobU). CobU is bifunctional cobalbumin biosynthesis enzymes which display adenosylcobinamide kinase and adenosylcobinamide phosphate guanyltransferase activity. This enzyme is a...; Region: CobU; cd00544 272562004597 homotrimer interface [polypeptide binding]; other site 272562004598 Walker A motif; other site 272562004599 GTP binding site [chemical binding]; other site 272562004600 Walker B motif; other site 272562004601 cobalamin synthase; Reviewed; Region: cobS; PRK00235 272562004602 Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067 272562004603 catalytic core [active] 272562004604 Metallo-beta-lactamase superfamily; Region: Lactamase_B; smart00849 272562004605 Four helix bundle sensory module for signal transduction; Region: 4HB_MCP_1; pfam12729 272562004606 Methyl-accepting chemotaxis protein [Cell motility and secretion / Signal transduction mechanisms]; Region: Tar; COG0840 272562004607 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 272562004608 dimerization interface [polypeptide binding]; other site 272562004609 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cl19050 272562004610 dimer interface [polypeptide binding]; other site 272562004611 putative CheW interface [polypeptide binding]; other site 272562004612 Uncharacterized conserved protein, contains double-stranded beta-helix domain [Function unknown]; Region: COG3837 272562004613 Bacterial surface proteins containing Ig-like domains [Cell motility and secretion]; Region: COG5492 272562004614 Clostridial hydrophobic, with a conserved W residue, domain; Region: ChW; smart00728 272562004615 Clostridial hydrophobic, with a conserved W residue, domain; Region: ChW; smart00728 272562004616 Clostridial hydrophobic, with a conserved W residue, domain; Region: ChW; smart00728 272562004617 Bacterial Ig-like domain (group 2); Region: Big_2; pfam02368 272562004618 Bacterial Ig-like domain (group 2); Region: Big_2; pfam02368 272562004619 Bacterial surface proteins containing Ig-like domains [Cell motility and secretion]; Region: COG5492 272562004620 Clostridial hydrophobic, with a conserved W residue, domain; Region: ChW; smart00728 272562004621 Clostridial hydrophobic, with a conserved W residue, domain; Region: ChW; smart00728 272562004622 Clostridial hydrophobic, with a conserved W residue, domain; Region: ChW; smart00728 272562004623 Clostridial hydrophobic, with a conserved W residue, domain; Region: ChW; smart00728 272562004624 Clostridial hydrophobic, with a conserved W residue, domain; Region: ChW; smart00728 272562004625 Phosphoribosylcarboxyaminoimidazole (NCAIR) mutase [Nucleotide transport and metabolism]; Region: PurE; COG0041 272562004626 bacterial and archaeal 5-aminoimidazole-4-(N-succinylcarboxamide) ribonucleotide (SAICAR) synthase; Region: SAICAR_synt_PurC; cd01415 272562004627 ATP binding site [chemical binding]; other site 272562004628 active site 272562004629 substrate binding site [chemical binding]; other site 272562004630 amidophosphoribosyltransferase; Provisional; Region: PRK05793 272562004631 Glutamine amidotransferases class-II (GN-AT)_GPAT- type. This domain is found at the N-terminus of glutamine phosphoribosylpyrophosphate (Prpp) amidotransferase (GPATase) . The glutaminase domain catalyzes amide nitrogen transfer from glutamine to the...; Region: GPATase_N; cd00715 272562004632 active site 272562004633 tetramer interface [polypeptide binding]; other site 272562004634 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 272562004635 active site 272562004636 phosphoribosylaminoimidazole synthetase; Provisional; Region: PRK05385 272562004637 PurM (Aminoimidazole Ribonucleotide [AIR] synthetase), one of eleven enzymes required for purine biosynthesis, catalyzes the conversion of formylglycinamide ribonucleotide (FGAM) and ATP to AIR, ADP, and Pi, the fifth step in de novo purine biosynthesis; Region: PurM; cd02196 272562004638 dimerization interface [polypeptide binding]; other site 272562004639 putative ATP binding site [chemical binding]; other site 272562004640 Phosphoribosylglycinamide formyltransferase (GAR transformylase, GART); Region: FMT_core_GART; cd08645 272562004641 active site 272562004642 substrate binding site [chemical binding]; other site 272562004643 cosubstrate binding site; other site 272562004644 catalytic site [active] 272562004645 bifunctional phosphoribosylaminoimidazolecarboxamide formyltransferase/IMP cyclohydrolase; Provisional; Region: purH; PRK00881 272562004646 Inosine monophosphate cyclohydrolase domain. This is the N-terminal domain in the purine biosynthesis pathway protein ATIC (purH). The bifunctional ATIC protein contains a C-terminal ATIC formylase domain that formylates...; Region: IMPCH; cd01421 272562004647 purine monophosphate binding site [chemical binding]; other site 272562004648 dimer interface [polypeptide binding]; other site 272562004649 putative catalytic residues [active] 272562004650 AICARFT/IMPCHase bienzyme; Region: AICARFT_IMPCHas; smart00798 272562004651 phosphoribosylamine--glycine ligase; Provisional; Region: PRK00885 272562004652 Phosphoribosylglycinamide synthetase, N domain; Region: GARS_N; pfam02844 272562004653 Phosphoribosylglycinamide synthetase, ATP-grasp (A) domain; Region: GARS_A; pfam01071 272562004654 Phosphoribosylglycinamide synthetase, C domain; Region: GARS_C; pfam02843 272562004655 Predicted metal-dependent hydrolases with the TIM-barrel fold [General function prediction only]; Region: COG1099 272562004656 TatD like proteins; E.coli TatD is a cytoplasmic protein, shown to have magnesium dependent DNase activity; Region: TatD_DNAse; cd01310 272562004657 active site 272562004658 Domain of unknown function DUF77; Region: DUF77; pfam01910 272562004659 ABC-type nitrate/sulfonate/bicarbonate transport system, permease component [Inorganic ion transport and metabolism]; Region: TauC; COG0600 272562004660 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 272562004661 dimer interface [polypeptide binding]; other site 272562004662 conserved gate region; other site 272562004663 putative PBP binding loops; other site 272562004664 ABC-ATPase subunit interface; other site 272562004665 ABC-type nitrate/sulfonate/bicarbonate transport systems, periplasmic components [Inorganic ion transport and metabolism]; Region: TauA; COG0715 272562004666 NMT1/THI5 like; Region: NMT1; pfam09084 272562004667 ABC-type nitrate/sulfonate/bicarbonate transport system, ATPase component [Inorganic ion transport and metabolism]; Region: TauB; COG1116 272562004668 ATP-binding cassette domain of the nitrate and sulfonate transporters; Region: ABC_NrtD_SsuB_transporters; cd03293 272562004669 Walker A/P-loop; other site 272562004670 ATP binding site [chemical binding]; other site 272562004671 Q-loop/lid; other site 272562004672 ABC transporter signature motif; other site 272562004673 Walker B; other site 272562004674 D-loop; other site 272562004675 H-loop/switch region; other site 272562004676 Protein involved in polysaccharide intercellular adhesin (PIA) synthesis/biofilm formation [Carbohydrate transport and metabolism]; Region: COG3936 272562004677 Metallo-beta-lactamase superfamily; Region: Lactamase_B; smart00849 272562004678 Transcriptional regulators of sugar metabolism [Transcription / Carbohydrate transport and metabolism]; Region: GlpR; COG1349 272562004679 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 272562004680 dimerization interface [polypeptide binding]; other site 272562004681 putative Zn2+ binding site [ion binding]; other site 272562004682 putative DNA binding site [nucleotide binding]; other site 272562004683 DeoR C terminal sensor domain; Region: DeoRC; pfam00455 272562004684 Beta-glucosidase/6-phospho-beta-glucosidase/beta- galactosidase [Carbohydrate transport and metabolism]; Region: BglB; COG2723 272562004685 Glycosyl hydrolase family 1; Region: Glyco_hydro_1; pfam00232 272562004686 transcriptional antiterminator BglG; Provisional; Region: PRK09772 272562004687 CAT RNA binding domain; Region: CAT_RBD; smart01061 272562004688 PRD domain; Region: PRD; pfam00874 272562004689 PRD domain; Region: PRD; pfam00874 272562004690 PTS system, beta-glucoside-specific IIABC component; Region: PTS-II-ABC-beta; TIGR01995 272562004691 PTS_IIB, PTS system, glucose/sucrose specific IIB subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIB_glc; cd00212 272562004692 active site turn [active] 272562004693 phosphorylation site [posttranslational modification] 272562004694 Phosphotransferase system IIC components, glucose/maltose/N-acetylglucosamine-specific [Carbohydrate transport and metabolism]; Region: PtsG; COG1263 272562004695 Phosphotransferase system IIA components [Carbohydrate transport and metabolism]; Region: NagE; COG2190 272562004696 HPr interaction site; other site 272562004697 glycerol kinase (GK) interaction site [polypeptide binding]; other site 272562004698 active site 272562004699 phosphorylation site [posttranslational modification] 272562004700 Glycosyl hydrolase family 1; Region: Glyco_hydro_1; pfam00232 272562004701 Beta-glucosidase/6-phospho-beta-glucosidase/beta- galactosidase [Carbohydrate transport and metabolism]; Region: BglB; cl01046 272562004702 Domain of unknown function (DUF4356); Region: DUF4356; pfam14266 272562004703 Domain of unknown function (DUF4356); Region: DUF4356; pfam14266 272562004704 Uncharacterized protein involved in tellurite resistance [Inorganic ion transport and metabolism]; Region: TelA; COG3853 272562004705 Toxic anion resistance protein (TelA); Region: TelA; pfam05816 272562004706 Uncharacterized proteins involved in stress response, similar to tellurium resistance terD; Region: TerD_like; cd06974 272562004707 putative metal binding site [ion binding]; other site 272562004708 Uncharacterized proteins involved in stress response, similar to tellurium resistance terD; Region: TerD_like; cd06974 272562004709 putative metal binding site [ion binding]; other site 272562004710 Uncharacterized proteins involved in stress response, similar to tellurium resistance terD; Region: TerD_like; cd06974 272562004711 putative metal binding site [ion binding]; other site 272562004712 integral membrane protein, YkoY family; Region: R_switched_YkoY; TIGR03716 272562004713 Acetyltransferases, including N-acetylases of ribosomal proteins [Translation, ribosomal structure and biogenesis]; Region: RimL; COG1670 272562004714 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 272562004715 Coenzyme A binding pocket [chemical binding]; other site 272562004716 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl17182 272562004717 Nitroreductase-like family 3. A subfamily of the nitroreductase family containing uncharacterized proteins that are similar to nitroreductase. Nitroreductase catalyzes the reduction of nitroaromatic compounds such as nitrotoluenes, nitrofurans and...; Region: Nitroreductase_3; cd02139 272562004718 putative FMN binding site [chemical binding]; other site 272562004719 Microcin C7 self-immunity protein determines resistance to exogenous microcin C7; Region: Peptidase_S66_mccF_like; cd07062 272562004720 putative dimer interface [polypeptide binding]; other site 272562004721 catalytic triad [active] 272562004722 hypothetical protein; Provisional; Region: PRK03881 272562004723 The N-terminal domain, an extradiol dioxygenase class III subunit B-like domain, of unknown proteins containing a C-terminal AMMECR1 domain; Region: ED_3B_N_AMMECR1; cd07951 272562004724 Uncharacterized conserved protein [Function unknown]; Region: AMMECR1; COG2078 272562004725 Pyruvate-formate lyase-activating enzyme [Posttranslational modification, protein turnover, chaperones]; Region: PflA; COG1180 272562004726 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 272562004727 FeS/SAM binding site; other site 272562004728 Hemolysins and related proteins containing CBS domains [General function prediction only]; Region: TlyC; COG1253 272562004729 Domain of unknown function DUF21; Region: DUF21; pfam01595 272562004730 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains associated with the CorC_HlyC domain. CorC_HlyC is a transporter associated domain. This small domain is found in Na+/H+ antiporters, in proteins involved in...; Region: CBS_pair_CorC_HlyC_assoc; cd04590 272562004731 Transporter associated domain; Region: CorC_HlyC; smart01091 272562004732 oxidoreductase; Provisional; Region: PRK06128 272562004733 classical (c) SDR, subgroup 1; Region: SDR_c1; cd05355 272562004734 NAD binding site [chemical binding]; other site 272562004735 metal binding site [ion binding]; metal-binding site 272562004736 active site 272562004737 Metallo-beta-lactamase superfamily; Region: Lactamase_B; smart00849 272562004738 Trimeric dUTP diphosphatases; Region: trimeric_dUTPase; cd07557 272562004739 trimer interface [polypeptide binding]; other site 272562004740 active site 272562004741 Regulator of polyketide synthase expression [Signal transduction mechanisms / Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG2508 272562004742 Purine catabolism regulatory protein-like family; Region: PucR; pfam07905 272562004743 PucR C-terminal helix-turn-helix domain; Region: HTH_30; pfam13556 272562004744 Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610 272562004745 Adenosylmethionine-8-amino-7-oxononanoate aminotransferase [Coenzyme metabolism]; Region: BioA; COG0161 272562004746 inhibitor-cofactor binding pocket; inhibition site 272562004747 pyridoxal 5'-phosphate binding site [chemical binding]; other site 272562004748 catalytic residue [active] 272562004749 UDP-glucose 4-epimerase [Cell envelope biogenesis, outer membrane]; Region: GalE; COG1087 272562004750 UDP-glucose 4 epimerase, subgroup 1, extended (e) SDRs; Region: UDP_G4E_1_SDR_e; cd05247 272562004751 NAD binding site [chemical binding]; other site 272562004752 homodimer interface [polypeptide binding]; other site 272562004753 active site 272562004754 substrate binding site [chemical binding]; other site 272562004755 Transcriptional regulators of sugar metabolism [Transcription / Carbohydrate transport and metabolism]; Region: GlpR; COG1349 272562004756 DeoR-like helix-turn-helix domain; Region: HTH_DeoR; cl17531 272562004757 DeoR C terminal sensor domain; Region: DeoRC; pfam00455 272562004758 RPI_A: Ribose 5-phosphate isomerase type A (RPI_A) subfamily; RPI catalyzes the reversible conversion of ribose-5-phosphate to ribulose 5-phosphate, the first step of the non-oxidative branch of the pentose phosphate pathway. This reaction leads to the...; Region: RPI_A; cd01398 272562004759 tetramer (dimer of dimers) interface [polypeptide binding]; other site 272562004760 active site 272562004761 dimer interface [polypeptide binding]; other site 272562004762 Cis (Z)-Isoprenyl Diphosphate Synthases; Region: Cis_IPPS; cd00475 272562004763 active site 272562004764 dimer interface [polypeptide binding]; other site 272562004765 Predicted hydrolases of the HAD superfamily [General function prediction only]; Region: Cof; COG0561 272562004766 haloacid dehalogenase-like hydrolase; Region: HAD; cl19137 272562004767 Phosphoglycerol transferase and related proteins, alkaline phosphatase superfamily [Cell envelope biogenesis, outer membrane]; Region: MdoB; COG1368 272562004768 Sulfatase; Region: Sulfatase; cl19157 272562004769 SAM-dependent methyltransferases related to tRNA (uracil-5-)-methyltransferase [Translation, ribosomal structure and biogenesis]; Region: TrmA; COG2265 272562004770 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 272562004771 S-adenosylmethionine binding site [chemical binding]; other site 272562004772 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cl18944 272562004773 Bacterial protein of unknown function (DUF961); Region: DUF961; pfam06125 272562004774 Glycopeptide antibiotics resistance protein [Defense mechanisms]; Region: VanZ; COG4767 272562004775 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 272562004776 Major Facilitator Superfamily; Region: MFS_1; pfam07690 272562004777 putative substrate translocation pore; other site 272562004778 Translation elongation factors (GTPases) [Translation, ribosomal structure and biogenesis]; Region: FusA; COG0480 272562004779 Tet(M)-like family includes Tet(M), Tet(O), Tet(W), and OtrA, containing tetracycline resistant proteins; Region: TetM_like; cd04168 272562004780 G1 box; other site 272562004781 putative GEF interaction site [polypeptide binding]; other site 272562004782 GTP/Mg2+ binding site [chemical binding]; other site 272562004783 Switch I region; other site 272562004784 G2 box; other site 272562004785 G3 box; other site 272562004786 Switch II region; other site 272562004787 G4 box; other site 272562004788 G5 box; other site 272562004789 Tet_II: This subfamily represents domain II of ribosomal protection proteins Tet(M) and Tet(O). This domain has homology to domain II of the elongation factors EF-G and EF-2. Tet(M) and Tet(O) catalyze the release of tetracycline (Tc) from the ribosome...; Region: Tet_II; cd03690 272562004790 Elongation Factor G, domain II; Region: EFG_II; pfam14492 272562004791 EF-G_domain IV_RPP domain is a part of bacterial ribosomal protected proteins (RPP) family. RPPs such as tetracycline resistance proteins Tet(M) and Tet(O) mediate tetracycline resistance in both gram-positive and -negative species. Tetracyclines inhibit...; Region: Tet_like_IV; cd01684 272562004792 Tet_C: C-terminus of ribosomal protection proteins Tet(M) and Tet(O). This domain has homology to the C terminal domains of the elongation factors EF-G and EF-2. Tet(M) and Tet(O) catalyze the release of tetracycline (Tc) from the ribosome in a...; Region: Tet_C; cd03711 272562004793 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 272562004794 AraC-like ligand binding domain; Region: AraC_binding; pfam02311 272562004795 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 272562004796 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 272562004797 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 272562004798 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 272562004799 Major Facilitator Superfamily; Region: MFS_1; pfam07690 272562004800 putative substrate translocation pore; other site 272562004801 ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: RbsB; COG1879 272562004802 Periplasmic sugar-binding domain of active transport systems that are members of the type I periplasmic binding protein (PBP1) superfamily; Region: PBP1_ABC_sugar_binding_like; cd01536 272562004803 ligand binding site [chemical binding]; other site 272562004804 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: COG4585 272562004805 Histidine kinase; Region: HisKA_3; pfam07730 272562004806 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 272562004807 ATP binding site [chemical binding]; other site 272562004808 Mg2+ binding site [ion binding]; other site 272562004809 G-X-G motif; other site 272562004810 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 272562004811 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 272562004812 active site 272562004813 phosphorylation site [posttranslational modification] 272562004814 intermolecular recognition site; other site 272562004815 dimerization interface [polypeptide binding]; other site 272562004816 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 272562004817 dimerization interface [polypeptide binding]; other site 272562004818 DNA binding residues [nucleotide binding] 272562004819 ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653 272562004820 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; pfam01547 272562004821 PTS_IIA, PTS system, mannose/sorbose specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIA_man; cd00006 272562004822 active pocket/dimerization site; other site 272562004823 active site 272562004824 phosphorylation site [posttranslational modification] 272562004825 PTS_IIB, PTS system, Mannose/sorbose specific IIB subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIB_man; cd00001 272562004826 active site 272562004827 phosphorylation site [posttranslational modification] 272562004828 Phosphotransferase system, mannose/fructose/N-acetylgalactosamine-specific component IIC [Carbohydrate transport and metabolism]; Region: ManY; COG3715 272562004829 Phosphotransferase system, mannose/fructose/N-acetylgalactosamine-specific component IID [Carbohydrate transport and metabolism]; Region: ManZ; COG3716 272562004830 Beta-fructosidases (levanase/invertase) [Carbohydrate transport and metabolism]; Region: SacC; COG1621 272562004831 Glycosyl hydrolase family 32, beta-fructosidases; Region: GH32_B_Fructosidase; cd08996 272562004832 substrate binding [chemical binding]; other site 272562004833 active site 272562004834 Glycosyl hydrolase families: GH43, GH62, GH32, GH68; Region: GH43_62_32_68; cl14647 272562004835 Glycosyl hydrolases family 32 C terminal; Region: Glyco_hydro_32C; pfam08244 272562004836 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 272562004837 sequence-specific DNA binding site [nucleotide binding]; other site 272562004838 salt bridge; other site 272562004839 Excinuclease ATPase subunit [DNA replication, recombination, and repair]; Region: UvrA; COG0178 272562004840 ATP-binding cassette domain I of the excision repair protein UvrA; Region: ABC_UvrA_I; cd03270 272562004841 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 272562004842 Walker A/P-loop; other site 272562004843 ATP binding site [chemical binding]; other site 272562004844 Q-loop/lid; other site 272562004845 ABC transporter signature motif; other site 272562004846 Walker B; other site 272562004847 D-loop; other site 272562004848 H-loop/switch region; other site 272562004849 Transcriptional regulators [Transcription]; Region: MarR; COG1846 272562004850 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 272562004851 putative DNA binding site [nucleotide binding]; other site 272562004852 putative Zn2+ binding site [ion binding]; other site 272562004853 Uncharacterized conserved protein [Function unknown]; Region: COG2128 272562004854 Transcriptional regulators [Transcription]; Region: Lrp; COG1522 272562004855 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 272562004856 putative DNA binding site [nucleotide binding]; other site 272562004857 putative Zn2+ binding site [ion binding]; other site 272562004858 AsnC family; Region: AsnC_trans_reg; pfam01037 272562004859 Acetyltransferase (GNAT) domain; Region: Acetyltransf_10; pfam13673 272562004860 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 272562004861 Coenzyme A binding pocket [chemical binding]; other site 272562004862 Iron dependent repressor, N-terminal DNA binding domain; Region: Fe_dep_repress; pfam01325 272562004863 Helix-turn-helix diphteria tox regulatory element; Region: HTH_DTXR; smart00529 272562004864 Iron dependent repressor, metal binding and dimerization domain; Region: Fe_dep_repr_C; pfam02742 272562004865 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 272562004866 Ketopantoate reductase [Coenzyme metabolism]; Region: ApbA; COG1893 272562004867 Ketopantoate reductase PanE/ApbA; Region: ApbA; pfam02558 272562004868 Gamma-aminobutyrate permease and related permeases [Amino acid transport and metabolism]; Region: AnsP; COG1113 272562004869 Transmembrane amino acid transporter protein; Region: Aa_trans; cl17468 272562004870 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 272562004871 dimer interface [polypeptide binding]; other site 272562004872 conserved gate region; other site 272562004873 putative PBP binding loops; other site 272562004874 ABC-ATPase subunit interface; other site 272562004875 Periplasmic glycine betaine/choline-binding (lipo)protein of an ABC-type transport system (osmoprotectant binding protein) [Cell envelope biogenesis, outer membrane]; Region: OpuBC; COG1732 272562004876 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 272562004877 sulfate ABC transporter, ATP-binding protein; Region: 3a0106s01; TIGR00968 272562004878 Walker A/P-loop; other site 272562004879 ATP binding site [chemical binding]; other site 272562004880 Q-loop/lid; other site 272562004881 ABC transporter signature motif; other site 272562004882 Walker B; other site 272562004883 D-loop; other site 272562004884 H-loop/switch region; other site 272562004885 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 272562004886 dimer interface [polypeptide binding]; other site 272562004887 conserved gate region; other site 272562004888 putative PBP binding loops; other site 272562004889 ABC-ATPase subunit interface; other site 272562004890 30S ribosomal protein S4; Validated; Region: rpsD; PRK05327 272562004891 Ribosomal protein S4/S9 N-terminal domain; Region: Ribosomal_S4; pfam00163 272562004892 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 272562004893 RNA binding surface [nucleotide binding]; other site 272562004894 branched-chain amino acid aminotransferase; Provisional; Region: PRK13357 272562004895 BCAT_beta_family: Branched-chain aminotransferase catalyses the transamination of the branched-chain amino acids leusine, isoleucine and valine to their respective alpha-keto acids, alpha-ketoisocaproate, alpha-keto-beta-methylvalerate and...; Region: BCAT_beta_family; cd01557 272562004896 homodimer interface [polypeptide binding]; other site 272562004897 substrate-cofactor binding pocket; other site 272562004898 catalytic residue [active] 272562004899 Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673 272562004900 Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408 272562004901 Oxidoreductase family, C-terminal alpha/beta domain; Region: GFO_IDH_MocA_C; pfam02894 272562004902 Transcriptional regulator [Transcription]; Region: LysR; COG0583 272562004903 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 272562004904 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cd05466 272562004905 dimerization interface [polypeptide binding]; other site 272562004906 Uncharacterized membrane protein, possible Na+ channel or pump [General function prediction only]; Region: COG1811 272562004907 Predicted transcriptional regulators [Transcription]; Region: COG1733 272562004908 Nitroreductase-like family 3. A subfamily of the nitroreductase family containing uncharacterized proteins that are similar to nitroreductase. Nitroreductase catalyzes the reduction of nitroaromatic compounds such as nitrotoluenes, nitrofurans and...; Region: Nitroreductase_3; cd02139 272562004909 putative FMN binding site [chemical binding]; other site 272562004910 Glycosyltransferases, probably involved in cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: COG1215 272562004911 CESA_CelA_like are involved in the elongation of the glucan chain of cellulose; Region: CESA_CelA_like; cd06421 272562004912 DXD motif; other site 272562004913 PilZ domain; Region: PilZ; pfam07238 272562004914 Uncharacterized protein family (UPF0180); Region: UPF0180; pfam03698 272562004915 small acid-soluble spore protein Tlp; Provisional; Region: PRK03830 272562004916 putative glycosyl transferase; Provisional; Region: PRK10073 272562004917 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cd00761 272562004918 active site 272562004919 Membrane-associated phospholipid phosphatase [Lipid metabolism]; Region: PgpB; COG0671 272562004920 PAP2_like proteins, a super-family of histidine phosphatases and vanadium haloperoxidases, includes type 2 phosphatidic acid phosphatase or lipid phosphate phosphatase (LPP), Glucose-6-phosphatase, Phosphatidylglycerophosphatase B and bacterial acid...; Region: PAP2_like; cl00474 272562004921 active site 272562004922 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4185 272562004923 Pirin-related protein [General function prediction only]; Region: COG1741 272562004924 Pirin; Region: Pirin; pfam02678 272562004925 Pirin C-terminal cupin domain; Region: Pirin_C; pfam05726 272562004926 Dihydrofolate reductase [Coenzyme metabolism]; Region: FolA; COG0262 272562004927 folate binding site [chemical binding]; other site 272562004928 NADP+ binding site [chemical binding]; other site 272562004929 Predicted nucleotidyltransferase [General function prediction only]; Region: COG3541 272562004930 Predicted nucleotidyltransferase; Region: Nuc-transf; pfam10127 272562004931 NADPH-dependent FMN reductase; Region: FMN_red; cl00438 272562004932 Predicted EndoIII-related endonuclease [DNA replication, recombination, and repair]; Region: Nth; COG0177 272562004933 endonuclease III; includes endonuclease III (DNA-(apurinic or apyrimidinic site) lyase), alkylbase DNA glycosidases (Alka-family) and other DNA glycosidases; Region: ENDO3c; cd00056 272562004934 minor groove reading motif; other site 272562004935 helix-hairpin-helix signature motif; other site 272562004936 substrate binding pocket [chemical binding]; other site 272562004937 active site 272562004938 Cytosine-C5 specific DNA methylases; Methyl transfer reactions play an important role in many aspects of biology. Cytosine-specific DNA methylases are found both in prokaryotes and eukaryotes. DNA methylation, or the covalent addition of a methyl group...; Region: Cyt_C5_DNA_methylase; cl19095 272562004939 cofactor binding site; other site 272562004940 DNA binding site [nucleotide binding] 272562004941 substrate interaction site [chemical binding]; other site 272562004942 seryl-tRNA synthetase; Region: PLN02678 272562004943 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 272562004944 H+ Antiporter protein; Region: 2A0121; TIGR00900 272562004945 putative substrate translocation pore; other site 272562004946 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 272562004947 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 272562004948 active site 272562004949 phosphorylation site [posttranslational modification] 272562004950 intermolecular recognition site; other site 272562004951 dimerization interface [polypeptide binding]; other site 272562004952 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 272562004953 DNA binding site [nucleotide binding] 272562004954 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 272562004955 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 272562004956 dimerization interface [polypeptide binding]; other site 272562004957 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 272562004958 dimer interface [polypeptide binding]; other site 272562004959 phosphorylation site [posttranslational modification] 272562004960 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 272562004961 ATP binding site [chemical binding]; other site 272562004962 Mg2+ binding site [ion binding]; other site 272562004963 G-X-G motif; other site 272562004964 RNA polymerase sigma-70 factor, TIGR02952 family; Region: Sig70_famx2 272562004965 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 272562004966 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cl17257 272562004967 DNA binding residues [nucleotide binding] 272562004968 Domain of unknown function (DUF4367); Region: DUF4367; pfam14285 272562004969 cAMP-binding proteins - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases [Signal transduction mechanisms]; Region: Crp; COG0664 272562004970 effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038 272562004971 ligand binding site [chemical binding]; other site 272562004972 flexible hinge region; other site 272562004973 Crp-like helix-turn-helix domain; Region: HTH_Crp_2; pfam13545 272562004974 putative switch regulator; other site 272562004975 non-specific DNA interactions [nucleotide binding]; other site 272562004976 DNA binding site [nucleotide binding] 272562004977 sequence specific DNA binding site [nucleotide binding]; other site 272562004978 putative cAMP binding site [chemical binding]; other site 272562004979 Formate/nitrite family of transporters [Inorganic ion transport and metabolism]; Region: FocA; COG2116 272562004980 anaerobic sulfite reductase subunit A; Provisional; Region: PRK15055 272562004981 sulfite reductase, subunit A; Region: sulfite_red_A; TIGR02910 272562004982 anaerobic sulfite reductase subunit B; Provisional; Region: PRK08221 272562004983 Anaerobic sulfite reductase contains an FAD and NADPH binding module with structural similarity to ferredoxin reductase and sequence similarity to dihydroorotate dehydrogenases. Clostridium pasteurianum inducible dissimilatory type sulfite reductase is...; Region: sulfite_reductase_like; cd06221 272562004984 FAD binding pocket [chemical binding]; other site 272562004985 FAD binding motif [chemical binding]; other site 272562004986 phosphate binding motif [ion binding]; other site 272562004987 beta-alpha-beta structure motif; other site 272562004988 NAD binding pocket [chemical binding]; other site 272562004989 Iron coordination center [ion binding]; other site 272562004990 sulfite reductase, subunit C; Region: sulfite_red_C; TIGR02912 272562004991 Nitrite/Sulfite reductase ferredoxin-like half domain; Region: NIR_SIR_ferr; pfam03460 272562004992 Nitrite and sulphite reductase 4Fe-4S domain; Region: NIR_SIR; pfam01077 272562004993 The HCP family of iron-sulfur proteins includes hybrid cluster protein (HCP), acetyl-CoA synthase (ACS), and carbon monoxide dehydrogenase (CODH), all of which contain [Fe4-S4] metal clusters at their active sites. These proteins have a conserved...; Region: HCP_like; cl19102 272562004994 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 272562004995 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 272562004996 active site 272562004997 phosphorylation site [posttranslational modification] 272562004998 intermolecular recognition site; other site 272562004999 dimerization interface [polypeptide binding]; other site 272562005000 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 272562005001 DNA binding site [nucleotide binding] 272562005002 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 272562005003 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 272562005004 dimer interface [polypeptide binding]; other site 272562005005 phosphorylation site [posttranslational modification] 272562005006 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 272562005007 ATP binding site [chemical binding]; other site 272562005008 Mg2+ binding site [ion binding]; other site 272562005009 G-X-G motif; other site 272562005010 ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136 272562005011 ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255 272562005012 Walker A/P-loop; other site 272562005013 ATP binding site [chemical binding]; other site 272562005014 Q-loop/lid; other site 272562005015 ABC transporter signature motif; other site 272562005016 Walker B; other site 272562005017 D-loop; other site 272562005018 H-loop/switch region; other site 272562005019 ABC-type antimicrobial peptide transport system, permease component [Defense mechanisms]; Region: SalY; COG0577 272562005020 FtsX-like permease family; Region: FtsX; pfam02687 272562005021 ABC-type antimicrobial peptide transport system, permease component [Defense mechanisms]; Region: SalY; COG0577 272562005022 FtsX-like permease family; Region: FtsX; pfam02687 272562005023 Domain of unknown function (DUF4363); Region: DUF4363; pfam14276 272562005024 Predicted membrane protein [Function unknown]; Region: COG2323 272562005025 Small, acid-soluble spore proteins, alpha/beta type; Region: SASP; pfam00269 272562005026 Transcriptional regulator/sugar kinase [Transcription / Carbohydrate transport and metabolism]; Region: NagC; COG1940 272562005027 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cd00012 272562005028 nucleotide binding site [chemical binding]; other site 272562005029 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cl17037 272562005030 Uncharacterized protein conserved in archaea (DUF2111); Region: DUF2111; cl01667 272562005031 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cl19050 272562005032 dimer interface [polypeptide binding]; other site 272562005033 putative CheW interface [polypeptide binding]; other site 272562005034 Escherichia coli PhnB and similar proteins; the E. coli phnB gene is found next to an operon involved in the cleavage of carbon-phosphorus bonds in unactivated alkylphosphonates; Region: PhnB_like; cd06588 272562005035 dimer interface [polypeptide binding]; other site 272562005036 CHAP domain; Region: CHAP; pfam05257 272562005037 Spore germination protein; Region: Spore_permease; pfam03845 272562005038 Glycosyl hydrolase family 43; Region: GH43_1; cd08980 272562005039 active site 272562005040 galactoside permease; Reviewed; Region: lacY; PRK09528 272562005041 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 272562005042 putative substrate translocation pore; other site 272562005043 Uncharacterized conserved protein [Function unknown]; Region: COG2461 272562005044 Family of unknown function (DUF438); Region: DUF438; pfam04282 272562005045 Hemerythrin HHE cation binding domain; Region: Hemerythrin; pfam01814 272562005046 Bacterial surface proteins containing Ig-like domains [Cell motility and secretion]; Region: COG5492 272562005047 Clostridial hydrophobic, with a conserved W residue, domain; Region: ChW; smart00728 272562005048 Clostridial hydrophobic, with a conserved W residue, domain; Region: ChW; smart00728 272562005049 Clostridial hydrophobic, with a conserved W residue, domain; Region: ChW; smart00728 272562005050 Clostridial hydrophobic, with a conserved W residue, domain; Region: ChW; smart00728 272562005051 Clostridial hydrophobic, with a conserved W residue, domain; Region: ChW; smart00728 272562005052 Clostridial hydrophobic, with a conserved W residue, domain; Region: ChW; smart00728 272562005053 MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704 272562005054 FtsX-like permease family; Region: FtsX; pfam02687 272562005055 ABC-type transport system, involved in lipoprotein release, permease component [Cell envelope biogenesis, outer membrane]; Region: LolE; COG4591 272562005056 FtsX-like permease family; Region: FtsX; pfam02687 272562005057 ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136 272562005058 ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255 272562005059 Walker A/P-loop; other site 272562005060 ATP binding site [chemical binding]; other site 272562005061 Q-loop/lid; other site 272562005062 ABC transporter signature motif; other site 272562005063 Walker B; other site 272562005064 D-loop; other site 272562005065 H-loop/switch region; other site 272562005066 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 272562005067 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 272562005068 Uncharacterized conserved protein [Function unknown]; Region: COG2013 272562005069 Permeases of the drug/metabolite transporter (DMT) superfamily [Carbohydrate transport and metabolism / Amino acid transport and metabolism / General function prediction only]; Region: RhaT; COG0697 272562005070 EamA-like transporter family; Region: EamA; pfam00892 272562005071 EamA-like transporter family; Region: EamA; pfam00892 272562005072 Probable zinc-binding domain; Region: zf-trcl; pfam13451 272562005073 Gamma-glutamylcysteine synthetase [Coenzyme metabolism]; Region: GshA; COG2918 272562005074 D-alanine-D-alanine ligase and related ATP-grasp enzymes [Cell envelope biogenesis, outer membrane]; Region: DdlA; COG1181 272562005075 ATP-grasp domain; Region: ATP-grasp_4; cl17255 272562005076 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cl17037 272562005077 Lactate dehydrogenase and related dehydrogenases [Energy production and conversion / Coenzyme metabolism / General function prediction only]; Region: LdhA; COG1052 272562005078 Putative Lactate dehydrogenase and (R)-2-Hydroxyglutarate Dehydrogenase-like proteins, NAD-binding and catalytic domains; Region: HGDH_LDH_like; cd12185 272562005079 putative ligand binding site [chemical binding]; other site 272562005080 putative NAD binding site [chemical binding]; other site 272562005081 catalytic site [active] 272562005082 Cytidine deaminase [Nucleotide transport and metabolism]; Region: Cdd; COG0295 272562005083 Cytidine deaminase zinc-binding domain. These enzymes are Zn dependent. The zinc ion in the active site plays a central role in the proposed catalytic mechanism, activating a water molecule to form a hydroxide ion that performs a nucleophilic attack on...; Region: cytidine_deaminase; cd01283 272562005084 active site 272562005085 catalytic motif [active] 272562005086 Zn binding site [ion binding]; other site 272562005087 2-deoxyribose-5-phosphate aldolase (DERA) of the DeoC family; Region: DeoC; cd00959 272562005088 intersubunit interface [polypeptide binding]; other site 272562005089 active site 272562005090 catalytic residue [active] 272562005091 pyrimidine-nucleoside phosphorylase; Reviewed; Region: PRK06078 272562005092 Glycosyl transferase family, helical bundle domain; Region: Glycos_trans_3N; pfam02885 272562005093 Glycosyl transferase family, a/b domain; Region: Glycos_transf_3; pfam00591 272562005094 Pyrimidine nucleoside phosphorylase C-terminal domain; Region: PYNP_C; pfam07831 272562005095 TRX family; composed of two groups: Group I, which includes proteins that exclusively encode a TRX domain; and Group II, which are composed of fusion proteins of TRX and additional domains. Group I TRX is a small ancient protein that alter the redox...; Region: TRX_family; cd02947 272562005096 catalytic residues [active] 272562005097 Thioredoxin reductase [Posttranslational modification, protein turnover, chaperones]; Region: TrxB; COG0492 272562005098 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl19134 272562005099 Glutathione (GSH) peroxidase family; tetrameric selenoenzymes that catalyze the reduction of a variety of hydroperoxides including lipid peroxidases, using GSH as a specific electron donor substrate. GSH peroxidase contains one selenocysteine residue per...; Region: GSH_Peroxidase; cd00340 272562005100 catalytic residues [active] 272562005101 dimer interface [polypeptide binding]; other site 272562005102 methionine sulfoxide reductase B; Provisional; Region: PRK00222 272562005103 NAD(P)H:flavin oxidoreductase-like family 1. A subfamily of the nitroreductase family containing uncharacterized proteins that are similar to nitroreductase. Nitroreductase catalyzes the reduction of nitroaromatic compounds such as nitrotoluenes; Region: NADPH_oxidoreductase_1; cd02150 272562005104 putative FMN binding site [chemical binding]; other site 272562005105 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 272562005106 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 272562005107 active site 272562005108 phosphorylation site [posttranslational modification] 272562005109 intermolecular recognition site; other site 272562005110 dimerization interface [polypeptide binding]; other site 272562005111 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 272562005112 DNA binding site [nucleotide binding] 272562005113 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 272562005114 HAMP domain; Region: HAMP; pfam00672 272562005115 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 272562005116 dimer interface [polypeptide binding]; other site 272562005117 phosphorylation site [posttranslational modification] 272562005118 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 272562005119 ATP binding site [chemical binding]; other site 272562005120 Mg2+ binding site [ion binding]; other site 272562005121 G-X-G motif; other site 272562005122 Heavy-metal-associated domain (HMA) is a conserved domain of approximately 30 amino acid residues found in a number of proteins that transport or detoxify heavy metals, for example, the CPx-type heavy metal ATPases and copper chaperones. HMA domain...; Region: HMA; cd00371 272562005123 metal-binding site [ion binding] 272562005124 Uncharacterized conserved protein [Function unknown]; Region: COG2836 272562005125 Plastocyanin domain containing protein [General function prediction only]; Region: COG4633 272562005126 Cupredoxin-like domain; Region: Cupredoxin_1; cl17234 272562005127 Flagellin and related hook-associated proteins [Cell motility and secretion]; Region: FlgL; COG1344 272562005128 Bacterial flagellin N-terminal helical region; Region: Flagellin_N; pfam00669 272562005129 Bacterial flagellin C-terminal helical region; Region: Flagellin_C; pfam00700 272562005130 Predicted glycosyl hydrolase [General function prediction only]; Region: COG3858 272562005131 Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all...; Region: FN3; cd00063 272562005132 Interdomain contacts; other site 272562005133 Cytokine receptor motif; other site 272562005134 Cortical fragment-lytic enzyme (CFLE) is a peptidoglycan hydrolase involved in bacterial endospore germination. CFLE is expressed as an inactive preprotein (called SleB) in the forespore compartment of sporulating cells. SleB translocates across the...; Region: GH18_CFLE_spore_hydrolase; cd02874 272562005135 active site 272562005136 Acetyltransferase (GNAT) domain; Region: Acetyltransf_3; pfam13302 272562005137 Acetyltransferase (GNAT) family; Region: Acetyltransf_1; pfam00583 272562005138 ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132 272562005139 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 272562005140 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 272562005141 Walker A/P-loop; other site 272562005142 ATP binding site [chemical binding]; other site 272562005143 Q-loop/lid; other site 272562005144 ABC transporter signature motif; other site 272562005145 Walker B; other site 272562005146 D-loop; other site 272562005147 H-loop/switch region; other site 272562005148 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 272562005149 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 272562005150 non-specific DNA binding site [nucleotide binding]; other site 272562005151 salt bridge; other site 272562005152 sequence-specific DNA binding site [nucleotide binding]; other site 272562005153 Cro/C1-type HTH DNA-binding domain; Region: HTH_26; pfam13443 272562005154 Glycosyltransferases, probably involved in cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: COG1215 272562005155 CESA_CelA_like are involved in the elongation of the glucan chain of cellulose; Region: CESA_CelA_like; cd06421 272562005156 DXD motif; other site 272562005157 PilZ domain; Region: PilZ; pfam07238 272562005158 Cellulase (glycosyl hydrolase family 5); Region: Cellulase; pfam00150 272562005159 Predicted membrane protein involved in D-alanine export [Cell envelope biogenesis, outer membrane]; Region: DltB; COG1696 272562005160 DHHW protein; Region: DHHW; pfam14286 272562005161 PMP-22/EMP/MP20/Claudin tight junction; Region: Claudin_2; cl17758 272562005162 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 272562005163 metal binding site [ion binding]; metal-binding site 272562005164 active site 272562005165 I-site; other site 272562005166 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 272562005167 metal binding site [ion binding]; metal-binding site 272562005168 active site 272562005169 I-site; other site 272562005170 Transcriptional regulators [Transcription]; Region: MarR; COG1846 272562005171 helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347 272562005172 Glutathione (GSH) peroxidase family; tetrameric selenoenzymes that catalyze the reduction of a variety of hydroperoxides including lipid peroxidases, using GSH as a specific electron donor substrate. GSH peroxidase contains one selenocysteine residue per...; Region: GSH_Peroxidase; cd00340 272562005173 catalytic residues [active] 272562005174 dimer interface [polypeptide binding]; other site 272562005175 Glutathione (GSH) peroxidase family; tetrameric selenoenzymes that catalyze the reduction of a variety of hydroperoxides including lipid peroxidases, using GSH as a specific electron donor substrate. GSH peroxidase contains one selenocysteine residue per...; Region: GSH_Peroxidase; cd00340 272562005176 catalytic residues [active] 272562005177 dimer interface [polypeptide binding]; other site 272562005178 Firmicute fructose-1,6-bisphosphatase; Region: FBPase_2; pfam06874 272562005179 Protein of unknown function (DUF2992); Region: DUF2992; pfam11208 272562005180 Alcohol dehydrogenase, class IV [Energy production and conversion]; Region: EutG; COG1454 272562005181 active site 272562005182 NAD binding site [chemical binding]; other site 272562005183 metal binding site [ion binding]; metal-binding site 272562005184 conserved hypothetical protein; Region: TIGR02328 272562005185 oxidoreductase; Provisional; Region: PRK06128 272562005186 classical (c) SDR, subgroup 1; Region: SDR_c1; cd05355 272562005187 NAD binding site [chemical binding]; other site 272562005188 metal binding site [ion binding]; metal-binding site 272562005189 active site 272562005190 Uncharacterized BCR, COG1636; Region: DUF208; pfam02677 272562005191 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 272562005192 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 272562005193 non-specific DNA binding site [nucleotide binding]; other site 272562005194 salt bridge; other site 272562005195 sequence-specific DNA binding site [nucleotide binding]; other site 272562005196 ligand binding domain of Tar- and Tsr-related chemoreceptors; Region: Tar_Tsr_LBD; cl00144 272562005197 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cl19050 272562005198 Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer); Region: MA; smart00283 272562005199 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cl19050 272562005200 dimer interface [polypeptide binding]; other site 272562005201 putative CheW interface [polypeptide binding]; other site 272562005202 Uncharacterized protein conserved in bacteria with the myosin-like domain [Function unknown]; Region: COG4372 272562005203 Response regulator of the LytR/AlgR family [Transcription / Signal transduction mechanisms]; Region: LytT; COG3279 272562005204 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 272562005205 active site 272562005206 phosphorylation site [posttranslational modification] 272562005207 intermolecular recognition site; other site 272562005208 dimerization interface [polypeptide binding]; other site 272562005209 LytTr DNA-binding domain; Region: LytTR; pfam04397 272562005210 Predicted signal transduction protein with a C-terminal ATPase domain [Signal transduction mechanisms]; Region: COG2972 272562005211 GHKL domain; Region: HATPase_c_5; pfam14501 272562005212 AAA domain; Region: AAA_17; pfam13207 272562005213 AAA domain; Region: AAA_33; pfam13671 272562005214 ribonuclease Z; Region: RNase_Z; TIGR02651 272562005215 Permeases of the major facilitator superfamily [General function prediction only]; Region: COG2270 272562005216 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 272562005217 putative substrate translocation pore; other site 272562005218 Integral membrane protein possibly involved in chromosome condensation [Cell division and chromosome partitioning]; Region: CrcB; COG0239 272562005219 camphor resistance protein CrcB; Provisional; Region: PRK14232 272562005220 Transcriptional regulator [Transcription]; Region: LysR; COG0583 272562005221 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 272562005222 The substrate binding domain of LysR-type transcriptional regulator MleR which required for malolactic fermentation, contains type 2 periplasmic binidning fold; Region: PBP2_MleR; cd08437 272562005223 putative dimerization interface [polypeptide binding]; other site 272562005224 malate dehydrogenase; Provisional; Region: PRK13529 272562005225 Malic enzyme, N-terminal domain; Region: malic; pfam00390 272562005226 NAD(P) binding domain of malic enzyme (ME), subgroup 1; Region: NAD_bind_1_malic_enz; cd05312 272562005227 NAD(P) binding site [chemical binding]; other site 272562005228 Sodium:sulfate symporter transmembrane region; Region: Na_sulph_symp; pfam00939 272562005229 anion transporter; Region: dass; TIGR00785 272562005230 transmembrane helices; other site 272562005231 Predicted membrane protein [Function unknown]; Region: COG3689 272562005232 Predicted permeases [General function prediction only]; Region: COG0701 272562005233 ABC-type metal ion transport system, periplasmic component/surface adhesin [Inorganic ion transport and metabolism]; Region: LraI; COG0803 272562005234 Metal binding protein AcdA. These proteins have been shown to function in the ABC uptake of Zn2+ and Mn2+ and in competence for genetic transformation and adhesion. The AcdA proteins belong to the TroA superfamily of helical backbone metal receptor...; Region: AdcA; cd01017 272562005235 metal binding site [ion binding]; metal-binding site 272562005236 30S ribosomal protein S4; Validated; Region: rpsD; PRK05327 272562005237 Ribosomal protein S4/S9 N-terminal domain; Region: Ribosomal_S4; pfam00163 272562005238 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 272562005239 RNA binding surface [nucleotide binding]; other site 272562005240 INT_SG3, DNA breaking-rejoining enzymes, integrase/recombinases subgroup 3, catalytic domain. The CD contains various predicted bacterial and phage integrase/recombinase sequences for which not much experimental characterization is available; Region: INT_SG3_C; cd01186 272562005241 Int/Topo IB signature motif; other site 272562005242 malate dehydrogenase; Provisional; Region: PRK13529 272562005243 Malic enzyme, N-terminal domain; Region: malic; pfam00390 272562005244 NAD(P) binding domain of malic enzyme (ME), subgroup 1; Region: NAD_bind_1_malic_enz; cd05312 272562005245 NAD(P) binding site [chemical binding]; other site 272562005246 Sensory domain of two-component sensor kinase; Region: Cache_3; pfam14827 272562005247 Cache domain; Region: Cache_1; pfam02743 272562005248 Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer); Region: MA; smart00283 272562005249 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cl19050 272562005250 dimer interface [polypeptide binding]; other site 272562005251 putative CheW interface [polypeptide binding]; other site 272562005252 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cl19050 272562005253 dimer interface [polypeptide binding]; other site 272562005254 Methyl-accepting chemotaxis protein [Cell motility and secretion / Signal transduction mechanisms]; Region: Tar; COG0840 272562005255 putative CheW interface [polypeptide binding]; other site 272562005256 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4378 272562005257 2'-5' RNA ligase [Translation, ribosomal structure and biogenesis]; Region: LigT; COG1514 272562005258 LigT like Phosphoesterase; Region: LigT_PEase; pfam02834 272562005259 Methylglyoxal synthase catalyzes the enolization of dihydroxyacetone phosphate (DHAP) to produce methylglyoxal. The first part of the catalytic mechanism is believed to be similar to TIM (triosephosphate isomerase) in that both enzymes utilize DHAP to...; Region: MGS; cd01422 272562005260 active site 272562005261 dimer interfaces [polypeptide binding]; other site 272562005262 catalytic residues [active] 272562005263 Ketopantoate reductase PanE/ApbA; Region: ApbA; pfam02558 272562005264 2-dehydropantoate 2-reductase; Region: apbA_panE; TIGR00745 272562005265 Ketopantoate reductase PanE/ApbA C terminal; Region: ApbA_C; pfam08546 272562005266 Uncharacterized conserved protein [Function unknown]; Region: COG2454 272562005267 Domain of Unknown Function (DUF1599); Region: DUF1599; pfam07659 272562005268 Diadenosine tetraphosphate (Ap4A) hydrolase and other HIT family hydrolases [Nucleotide transport and metabolism / Carbohydrate transport and metabolism / General function prediction only]; Region: Hit; COG0537 272562005269 nucleotide binding site/active site [active] 272562005270 HIT family signature motif; other site 272562005271 catalytic residue [active] 272562005272 Transcription elongation factor Elf1 like; Region: Elf1; cl02038 272562005273 Branched-chain amino acid transport protein; Region: Branch_AA_trans; pfam05525 272562005274 ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132 272562005275 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 272562005276 ATP-binding cassette domain of the bacterial lipid flippase and related proteins, subfamily C; Region: ABCC_MsbA; cd03251 272562005277 Walker A/P-loop; other site 272562005278 ATP binding site [chemical binding]; other site 272562005279 Q-loop/lid; other site 272562005280 ABC transporter signature motif; other site 272562005281 Walker B; other site 272562005282 D-loop; other site 272562005283 H-loop/switch region; other site 272562005284 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394 272562005285 active site 272562005286 Glycosyltransferase like family 2; Region: Glyco_tranf_2_3; pfam13641 272562005287 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cd00761 272562005288 active site 272562005289 Small, acid-soluble spore proteins, alpha/beta type; Region: SASP; pfam00269 272562005290 Fe-S oxidoreductases [Energy production and conversion]; Region: COG0731 272562005291 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 272562005292 FeS/SAM binding site; other site 272562005293 Pyridoxal kinase plays a key role in the synthesis of the active coenzyme pyridoxal-5'-phosphate (PLP), by catalyzing the phosphorylation of the precursor vitamin B6 in the presence of Zn2+ and ATP. Mammals are unable to synthesize PLP de novo and...; Region: pyridoxal_pyridoxamine_kinase; cd01173 272562005294 dimer interface [polypeptide binding]; other site 272562005295 pyridoxal binding site [chemical binding]; other site 272562005296 ATP binding site [chemical binding]; other site 272562005297 Uncharacterized ACR, YkgG family COG1556; Region: DUF162; pfam02589 272562005298 Uncharacterized protein, DegV family COG1307; Region: DegV; pfam02645 272562005299 Uncharacterized conserved protein [Function unknown]; Region: COG4359 272562005300 Glycerol-1-phosphate_dehydrogenase and related proteins; Region: G1PDH_related; cd08549 272562005301 active site 272562005302 metal binding site [ion binding]; metal-binding site 272562005303 DNA topoisomerase IV subunit B; Reviewed; Region: PRK05559 272562005304 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 272562005305 ATP binding site [chemical binding]; other site 272562005306 Mg2+ binding site [ion binding]; other site 272562005307 G-X-G motif; other site 272562005308 TopoIIA_Trans_DNA_gyrase: Transducer domain, having a ribosomal S5 domain 2-like fold, of the type found in proteins of the type IIA family of DNA topoisomerases similar to the B subunits of E. coli DNA gyrase and E. coli Topoisomerase IV which are; Region: TopoII_Trans_DNA_gyrase; cd00822 272562005309 anchoring element; other site 272562005310 dimer interface [polypeptide binding]; other site 272562005311 ATP binding site [chemical binding]; other site 272562005312 Topoisomerase-primase domain. This is a nucleotidyl transferase/hydrolase domain found in type IA, type IIA and type IIB topoisomerases, bacterial DnaG-type primases, small primase-like proteins from bacteria and archaea, OLD family nucleases from...; Region: TOPRIM; cl00718 272562005313 active site 272562005314 metal binding site [ion binding]; metal-binding site 272562005315 DNA gyrase B subunit, carboxyl terminus; Region: DNA_gyraseB_C; pfam00986 272562005316 DNA topoisomerase IV subunit A; Provisional; Region: PRK13979 272562005317 DNA Topoisomerase, subtype IIA; domain A'; bacterial DNA topoisomerase IV (C subunit, ParC), bacterial DNA gyrases (A subunit, GyrA),mammalian DNA toposiomerases II. DNA topoisomerases are essential enzymes that regulate the conformational changes...; Region: TOP4c; cd00187 272562005318 CAP-like domain; other site 272562005319 active site 272562005320 primary dimer interface [polypeptide binding]; other site 272562005321 DJ-1 family protein; Region: not_thiJ; TIGR01383 272562005322 Type 1 glutamine amidotransferase (GATase1)-like domain found in Human DJ-1; Region: GATase1_DJ-1; cd03135 272562005323 conserved cys residue [active] 272562005324 Predicted Zn-dependent peptidases [General function prediction only]; Region: PqqL; COG0612 272562005325 Insulinase (Peptidase family M16); Region: Peptidase_M16; pfam00675 272562005326 Peptidase M16 inactive domain; Region: Peptidase_M16_C; pfam05193 272562005327 biotin synthase; Provisional; Region: PRK07094 272562005328 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 272562005329 FeS/SAM binding site; other site 272562005330 Biotin and Thiamin Synthesis associated domain; Region: BATS; cl06149 272562005331 Endonuclease IV [DNA replication, recombination, and repair]; Region: Nfo; COG0648 272562005332 AP endonuclease family 2; These endonucleases play a role in DNA repair. Cleave phosphodiester bonds at apurinic or apyrimidinic sites; the alignment also contains hexulose-6-phosphate isomerases, enzymes that catalyze the epimerization of...; Region: AP2Ec; cd00019 272562005333 AP (apurinic/apyrimidinic) site pocket; other site 272562005334 DNA interaction; other site 272562005335 Metal-binding active site; metal-binding site 272562005336 Manganese catalase-like protein, ferritin-like diiron-binding domain; Region: Mn_catalase_like; cd07908 272562005337 Ferritin-like domain; Region: Ferritin; pfam00210 272562005338 dinuclear metal binding motif [ion binding]; other site 272562005339 Flagellin and related hook-associated proteins [Cell motility and secretion]; Region: FlgL; COG1344 272562005340 Bacterial flagellin N-terminal helical region; Region: Flagellin_N; pfam00669 272562005341 Bacterial flagellin C-terminal helical region; Region: Flagellin_C; pfam00700 272562005342 Predicted RNA-bindining protein (contains S1 and HTH domains) [General function prediction only]; Region: COG2996 272562005343 S1 domain; Region: S1_2; pfam13509 272562005344 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4495 272562005345 ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other...; Region: ANK; cd00204 272562005346 Ankyrin repeats (3 copies); Region: Ank_2; pfam12796 272562005347 Uncharacterized conserved protein [Function unknown]; Region: COG5620 272562005348 GAD-like domain; Region: GAD-like; pfam08887 272562005349 Domain of unknown function (DUF1851); Region: DUF1851; pfam08906 272562005350 NAD+--asparagine ADP-ribosyltransferase [Signal transduction mechanisms]; Region: COG5585 272562005351 A nuclease family of the HNH/ENDO VII superfamily with conserved AHH; Region: AHH; pfam14412 272562005352 Ankyrin repeats (3 copies); Region: Ank_2; pfam12796 272562005353 ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other...; Region: ANK; cd00204 272562005354 Ankyrin repeats (3 copies); Region: Ank_2; pfam12796 272562005355 Ankyrin repeats (3 copies); Region: Ank_2; pfam12796 272562005356 Suppressor of fused protein (SUFU); Region: SUFU; pfam05076 272562005357 NAD+--asparagine ADP-ribosyltransferase [Signal transduction mechanisms]; Region: COG5585 272562005358 A nuclease of the HNH/ENDO VII superfamily with conserved WHH; Region: WHH; pfam14414 272562005359 Protein of unknown function (DUF2004); Region: DUF2004; pfam09406 272562005360 NAD+--asparagine ADP-ribosyltransferase [Signal transduction mechanisms]; Region: COG5585 272562005361 Putative toxin 43; Region: Toxin_43; pfam15604 272562005362 [FeFe] hydrogenase H-cluster maturation GTPase HydF; Region: GTP_HydF; TIGR03918 272562005363 E. coli Ras-like protein (Era)-like GTPase; Region: Era_like; cd00880 272562005364 G1 box; other site 272562005365 GTP/Mg2+ binding site [chemical binding]; other site 272562005366 Switch I region; other site 272562005367 G2 box; other site 272562005368 Switch II region; other site 272562005369 G3 box; other site 272562005370 G4 box; other site 272562005371 G5 box; other site 272562005372 aspartate ammonia-lyase; Provisional; Region: aspA; PRK12273 272562005373 Aspartase; Region: Aspartase; cd01357 272562005374 active sites [active] 272562005375 tetramer interface [polypeptide binding]; other site 272562005376 Glycosyltransferases involved in cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WcaA; COG0463 272562005377 DPM1_like represents putative enzymes similar to eukaryotic DPM1; Region: DPM1_like; cd06442 272562005378 Ligand binding site; other site 272562005379 Putative Catalytic site; other site 272562005380 DXD motif; other site 272562005381 Predicted Zn-dependent peptidases, insulinase-like [General function prediction only]; Region: COG1026 272562005382 Insulinase (Peptidase family M16); Region: Peptidase_M16; pfam00675 272562005383 Peptidase M16 inactive domain; Region: Peptidase_M16_C; pfam05193 272562005384 Peptidase M16C associated; Region: M16C_assoc; pfam08367 272562005385 phosphoribosylformylglycinamidine synthase, clade II; Region: FGAM-synthase; TIGR01857 272562005386 PurL subunit of the formylglycinamide ribonucleotide amidotransferase (FGAR-AT), first repeat. FGAR-AT catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to formylglycinamidine ribonucleotide (FGAM), ADP; Region: PurL_repeat1; cd02203 272562005387 dimerization interface [polypeptide binding]; other site 272562005388 ATP binding site [chemical binding]; other site 272562005389 PurL subunit of the formylglycinamide ribonucleotide amidotransferase (FGAR-AT), second repeat. FGAR-AT catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to formylglycinamidine ribonucleotide (FGAM), ADP; Region: PurL_repeat2; cd02204 272562005390 dimerization interface [polypeptide binding]; other site 272562005391 ATP binding site [chemical binding]; other site 272562005392 Type 1 glutamine amidotransferase (GATase1)-like domain found in Formylglycinamide ribonucleotide amidotransferase; Region: GATase1_FGAR_AT; cd01740 272562005393 putative active site [active] 272562005394 catalytic triad [active] 272562005395 SseB protein N-terminal domain; Region: SseB; pfam07179 272562005396 Pentapeptide repeats (9 copies); Region: Pentapeptide_4; pfam13599 272562005397 Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805 272562005398 Pentapeptide repeats (9 copies); Region: Pentapeptide_4; pfam13599 272562005399 Catalytic domain of EDTA-resistant nuclease Nuc from Salmonella typhimurium and similar proteins; Region: PLDc_Nuc; cd09170 272562005400 PLD-like domain; Region: PLDc_2; pfam13091 272562005401 putative active site [active] 272562005402 catalytic site [active] 272562005403 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cd00012 272562005404 nucleotide binding site [chemical binding]; other site 272562005405 Acetokinase family; Region: Acetate_kinase; cl17229 272562005406 Ribosomal protein L7/L12 [Translation, ribosomal structure and biogenesis]; Region: RplL; COG0222 272562005407 L11 interface [polypeptide binding]; other site 272562005408 putative EF-Tu interaction site [polypeptide binding]; other site 272562005409 putative EF-G interaction site [polypeptide binding]; other site 272562005410 small acid-soluble spore protein, H-type; Region: SASP_H; TIGR02861 272562005411 This is a family of oligosaccharide phosphorylases. It includes yeast and mammalian glycogen phosphorylases, plant starch/glucan phosphorylase, as well as the maltodextrin phosphorylases of bacteria. The members of this family catalyze the breakdown of...; Region: GT1_Glycogen_Phosphorylase; cd04300 272562005412 homodimer interface [polypeptide binding]; other site 272562005413 glycogen/starch/alpha-glucan phosphorylases; Region: P_ylase; TIGR02093 272562005414 active site pocket [active] 272562005415 Nitrilase superfamily, including nitrile- or amide-hydrolyzing enzymes and amide-condensing enzymes; Region: nitrilase; cl11424 272562005416 active site 272562005417 catalytic triad [active] 272562005418 dimer interface [polypeptide binding]; other site 272562005419 Predicted membrane protein [Function unknown]; Region: COG4905 272562005420 Predicted HD superfamily hydrolase [General function prediction only]; Region: COG1418 272562005421 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cl17215 272562005422 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 272562005423 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 272562005424 Carbon starvation protein, predicted membrane protein [Signal transduction mechanisms]; Region: CstA; COG1966 272562005425 Carbon starvation protein CstA; Region: CstA; pfam02554 272562005426 C-terminal domain on CstA (DUF4161); Region: DUF4161; pfam13722 272562005427 Response regulator of the LytR/AlgR family [Transcription / Signal transduction mechanisms]; Region: LytT; COG3279 272562005428 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 272562005429 active site 272562005430 phosphorylation site [posttranslational modification] 272562005431 intermolecular recognition site; other site 272562005432 dimerization interface [polypeptide binding]; other site 272562005433 LytTr DNA-binding domain; Region: LytTR; pfam04397 272562005434 ATPase related to the helicase subunit of the Holliday junction resolvase [DNA replication, recombination, and repair]; Region: MGS1; COG2256 272562005435 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 272562005436 Walker A motif; other site 272562005437 ATP binding site [chemical binding]; other site 272562005438 Walker B motif; other site 272562005439 arginine finger; other site 272562005440 MgsA AAA+ ATPase C terminal; Region: MgsA_C; pfam12002 272562005441 Rad3-related DNA helicases [Transcription / DNA replication, recombination, and repair]; Region: DinG; COG1199 272562005442 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cl17251 272562005443 DEAD_2; Region: DEAD_2; pfam06733 272562005444 Helicase C-terminal domain; Region: Helicase_C_2; pfam13307 272562005445 glutamate synthase subunit alpha; Provisional; Region: gltB; PRK11750 272562005446 Glutamine amidotransferases class-II (Gn-AT), glutamate synthase (GltS)-type. GltS is a homodimer that synthesizes L-glutamate from 2-oxoglutarate and L-glutamine, an important step in ammonia assimilation in bacteria, cyanobacteria and plants. The...; Region: GltS; cd00713 272562005447 active site 272562005448 dimer interface [polypeptide binding]; other site 272562005449 Glutamate synthase central domain; Region: Glu_syn_central; pfam04898 272562005450 Glutamate synthase (GltS) FMN-binding domain. GltS is a complex iron-sulfur flavoprotein that catalyzes the reductive synthesis of L-glutamate from 2-oxoglutarate and L-glutamine via intramolecular channelling of ammonia, a reaction in the plant, yeast...; Region: GltS_FMN; cd02808 272562005451 active site 272562005452 FMN binding site [chemical binding]; other site 272562005453 substrate binding site [chemical binding]; other site 272562005454 3Fe-4S cluster binding site [ion binding]; other site 272562005455 gltb_C. This domain is found at the C-terminus of the large subunit (gltB) of glutamate synthase (GltS). GltS encodes a complex iron-sulfur flavoprotein that catalyzes the synthesis of L-glutamate from L-glutamine and 2-oxoglutarate. It requires the...; Region: gltB_C; cd00982 272562005456 domain interface; other site 272562005457 glutamate synthase subunit beta; Reviewed; Region: gltD; PRK12810 272562005458 Dihydroprymidine dehydrogenase domain II, 4Fe-4S cluster; Region: Fer4_20; pfam14691 272562005459 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 272562005460 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450 272562005461 Predicted transcriptional regulator [Transcription]; Region: COG1959 272562005462 Rrf2 family protein; Region: rrf2_super; TIGR00738 272562005463 PRC-barrel domain containing protein [General function prediction only]; Region: COG3881 272562005464 PRC-barrel domain; Region: PRC; pfam05239 272562005465 PRC-barrel domain; Region: PRC; pfam05239 272562005466 Predicted permease, member of the PurR regulon [General function prediction only]; Region: yhhT; COG0628 272562005467 alanyl-tRNA synthetase; Reviewed; Region: alaS; PRK00252 272562005468 Alanyl-tRNA synthetase (AlaRS) class II core catalytic domain. AlaRS is a homodimer. It is responsible for the attachment of alanine to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for ATP-dependent...; Region: AlaRS_core; cd00673 272562005469 motif 1; other site 272562005470 active site 272562005471 motif 2; other site 272562005472 motif 3; other site 272562005473 Threonyl and Alanyl tRNA synthetase second additional domain; Region: tRNA_SAD; smart00863 272562005474 DHHA1 domain; Region: DHHA1; pfam02272 272562005475 hypothetical protein; Provisional; Region: PRK05473 272562005476 Holliday junction resolvase-like protein; Reviewed; Region: PRK00109 272562005477 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3906 272562005478 Ferric uptake regulator(Fur) and related metalloregulatory proteins; typically iron-dependent, DNA-binding repressors and activators; Region: Fur_like; cd07153 272562005479 metal binding site 2 [ion binding]; metal-binding site 272562005480 putative DNA binding helix; other site 272562005481 metal binding site 1 [ion binding]; metal-binding site 272562005482 dimer interface [polypeptide binding]; other site 272562005483 structural Zn2+ binding site [ion binding]; other site 272562005484 mRNA degradation ribonucleases J1/J2 (metallo-beta-lactamase superfamily) [Translation, ribosomal structure and biogenesis; Replication, recombination and repair]; Region: COG0595 272562005485 Metallo-beta-lactamase superfamily; Region: Lactamase_B; smart00849 272562005486 RNA-metabolizing metallo-beta-lactamase; Region: RMMBL; pfam07521 272562005487 Tyrosine phosphorylated protein A (TypA)/BipA family belongs to ribosome-binding GTPases; Region: TypA_BipA; cd01891 272562005488 GTP-binding protein TypA/BipA; Region: TypA_BipA; TIGR01394 272562005489 G1 box; other site 272562005490 putative GEF interaction site [polypeptide binding]; other site 272562005491 GTP/Mg2+ binding site [chemical binding]; other site 272562005492 Switch I region; other site 272562005493 G2 box; other site 272562005494 G3 box; other site 272562005495 Switch II region; other site 272562005496 G4 box; other site 272562005497 G5 box; other site 272562005498 BipA_TypA_II: domain II of BipA (also called TypA) having homology to domain II of the elongation factors (EFs) EF-G and EF-Tu. BipA is a highly conserved protein with global regulatory properties in Escherichia coli. BipA is phosphorylated on a...; Region: BipA_TypA_II; cd03691 272562005499 BipA_TypA_C: a C-terminal portion of BipA or TypA having homology to the C terminal domains of the elongation factors EF-G and EF-2. A member of the ribosome binding GTPase superfamily, BipA is widely distributed in bacteria and plants. BipA is a highly...; Region: BipA_TypA_C; cd03710 272562005500 proteins similar to Escherichia coli yceG; Region: yceG_like; cd08010 272562005501 dimerization interface [polypeptide binding]; other site 272562005502 Methyltransferase domain; Region: Methyltransf_31; pfam13847 272562005503 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 272562005504 S-adenosylmethionine binding site [chemical binding]; other site 272562005505 putative protease; Provisional; Region: PRK15452 272562005506 Collagenase and related proteases [Posttranslational modification, protein turnover, chaperones]; Region: COG0826 272562005507 Cell division protein FtsI/penicillin-binding protein 2 [Cell envelope biogenesis, outer membrane]; Region: FtsI; COG0768 272562005508 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; cl17760 272562005509 sporulation sigma factor SigK; Reviewed; Region: PRK05803 272562005510 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 272562005511 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 272562005512 DNA binding residues [nucleotide binding] 272562005513 Pilus retraction ATPase PilT. PilT is a nucleotide binding protein responsible for the retraction of type IV pili, likely by pili disassembly. This retraction provides the force required for travel of bacteria in low water environments by a mechanism...; Region: PilT; cd01131 272562005514 Walker A motif; other site 272562005515 ATP binding site [chemical binding]; other site 272562005516 Walker B motif; other site 272562005517 Glycosyltransferases, probably involved in cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: COG1215 272562005518 EpsO protein participates in the methanolan synthesis; Region: EpsO_like; cd06438 272562005519 DXD motif; other site 272562005520 Cell division ATPase FtsA [Cell division and chromosome partitioning]; Region: ftsA; COG0849 272562005521 Cell division protein FtsA; Region: FtsA; smart00842 272562005522 Cell division protein FtsA; Region: FtsA; pfam14450 272562005523 cell division protein FtsZ; Validated; Region: PRK09330 272562005524 FtsZ is a GTPase that is similar to the eukaryotic tubulins and is essential for cell division in prokaryotes. FtsZ is capable of polymerizing in a GTP-driven process into structures similar to those formed by tubulin. FtsZ forms a ring-shaped septum at...; Region: FtsZ_type1; cd02201 272562005525 nucleotide binding site [chemical binding]; other site 272562005526 SulA interaction site; other site 272562005527 sigma-E processing peptidase SpoIIGA; Region: spore_II_GA; TIGR02854 272562005528 sporulation sigma factor SigE; Reviewed; Region: PRK08301 272562005529 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 272562005530 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 272562005531 DNA binding residues [nucleotide binding] 272562005532 sporulation sigma factor SigG; Reviewed; Region: PRK08215 272562005533 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 272562005534 Sigma-70 region 3; Region: Sigma70_r3; pfam04539 272562005535 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 272562005536 DNA binding residues [nucleotide binding] 272562005537 Protein implicated in RNA metabolism, contains PRC-barrel domain [General function prediction only]; Region: COG1873; cl17889 272562005538 transcriptional regulator NrdR; Validated; Region: nrdR; PRK00464 272562005539 Restriction alleviation protein Lar; Region: Lar_restr_allev; cl08047 272562005540 ATP cone domain; Region: ATP-cone; pfam03477 272562005541 Multi-copper polyphenol oxidoreductase laccase; Region: Cu-oxidase_4; pfam02578 272562005542 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 272562005543 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 272562005544 active site 272562005545 phosphorylation site [posttranslational modification] 272562005546 intermolecular recognition site; other site 272562005547 dimerization interface [polypeptide binding]; other site 272562005548 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 272562005549 DNA binding site [nucleotide binding] 272562005550 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 272562005551 dimerization interface [polypeptide binding]; other site 272562005552 phosphate regulon sensor kinase PhoR; Region: phoR_proteo; TIGR02966 272562005553 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 272562005554 putative active site [active] 272562005555 heme pocket [chemical binding]; other site 272562005556 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 272562005557 dimer interface [polypeptide binding]; other site 272562005558 phosphorylation site [posttranslational modification] 272562005559 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 272562005560 ATP binding site [chemical binding]; other site 272562005561 Mg2+ binding site [ion binding]; other site 272562005562 G-X-G motif; other site 272562005563 ABC transporter, phosphonate, periplasmic substrate-binding protein; Region: Phosphonate-bd; cl19131 272562005564 ABC-type phosphate transport system, permease component [Inorganic ion transport and metabolism]; Region: PstC; COG0573 272562005565 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 272562005566 dimer interface [polypeptide binding]; other site 272562005567 conserved gate region; other site 272562005568 putative PBP binding loops; other site 272562005569 ABC-ATPase subunit interface; other site 272562005570 ABC-type phosphate transport system, permease component [Inorganic ion transport and metabolism]; Region: PstA; COG0581 272562005571 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 272562005572 dimer interface [polypeptide binding]; other site 272562005573 conserved gate region; other site 272562005574 putative PBP binding loops; other site 272562005575 ABC-ATPase subunit interface; other site 272562005576 phosphate transporter ATP-binding protein; Provisional; Region: PRK14240 272562005577 ATP-binding cassette domain of the phosphate transport system; Region: ABC_PstB_phosphate_transporter; cd03260 272562005578 Walker A/P-loop; other site 272562005579 ATP binding site [chemical binding]; other site 272562005580 Q-loop/lid; other site 272562005581 ABC transporter signature motif; other site 272562005582 Walker B; other site 272562005583 D-loop; other site 272562005584 H-loop/switch region; other site 272562005585 phosphate transport system regulatory protein PhoU; Region: phoU_full; TIGR02135 272562005586 PhoU domain; Region: PhoU; pfam01895 272562005587 PhoU domain; Region: PhoU; pfam01895 272562005588 Fe-S oxidoreductase, related to NifB/MoaA family [Energy production and conversion]; Region: COG1625 272562005589 PDZ domain, also called DHR (Dlg homologous region) or GLGF (after a conserved sequence motif). Many PDZ domains bind C-terminal polypeptides, though binding to internal (non-C-terminal) polypeptides and even to lipids has been demonstrated; Region: PDZ; cd00136 272562005590 Protein of unknown function (DUF512); Region: DUF512; pfam04459 272562005591 GTP-binding protein Der; Reviewed; Region: PRK00093 272562005592 EngA1 GTPase contains the first domain of EngA; Region: EngA1; cd01894 272562005593 G1 box; other site 272562005594 GTP/Mg2+ binding site [chemical binding]; other site 272562005595 Switch I region; other site 272562005596 G2 box; other site 272562005597 Switch II region; other site 272562005598 G3 box; other site 272562005599 G4 box; other site 272562005600 G5 box; other site 272562005601 EngA2 GTPase contains the second domain of EngA; Region: EngA2; cd01895 272562005602 G1 box; other site 272562005603 GTP/Mg2+ binding site [chemical binding]; other site 272562005604 Switch I region; other site 272562005605 G2 box; other site 272562005606 G3 box; other site 272562005607 Switch II region; other site 272562005608 G4 box; other site 272562005609 G5 box; other site 272562005610 KH-domain-like of EngA bacterial GTPase enzymes, C-terminal; Region: KH_dom-like; pfam14714 272562005611 NAD(P)H-dependent glycerol-3-phosphate dehydrogenase; Validated; Region: gpsA; PRK00094 272562005612 NAD-dependent glycerol-3-phosphate dehydrogenase N-terminus; Region: NAD_Gly3P_dh_N; pfam01210 272562005613 NAD-dependent glycerol-3-phosphate dehydrogenase C-terminus; Region: NAD_Gly3P_dh_C; pfam07479 272562005614 Stage IV sporulation protein A (spore_IV_A); Region: Spore_IV_A; pfam09547 272562005615 Rat sarcoma (Ras)-like superfamily of small guanosine triphosphatases (GTPases); Region: Ras_like_GTPase; cd00882 272562005616 G1 box; other site 272562005617 GTP/Mg2+ binding site [chemical binding]; other site 272562005618 G2 box; other site 272562005619 Switch I region; other site 272562005620 G3 box; other site 272562005621 Switch II region; other site 272562005622 G4 box; other site 272562005623 G5 box; other site 272562005624 Type II (periplasmic) bacterial L-asparaginase; Region: L-asparaginase_II; cd08964 272562005625 cytoplasmic asparaginase I; Provisional; Region: ansA; PRK09461 272562005626 active site 272562005627 homotetramer interface [polypeptide binding]; other site 272562005628 homodimer interface [polypeptide binding]; other site 272562005629 LL-diaminopimelate aminotransferase; Provisional; Region: PRK09276 272562005630 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 272562005631 pyridoxal 5'-phosphate binding site [chemical binding]; other site 272562005632 homodimer interface [polypeptide binding]; other site 272562005633 catalytic residue [active] 272562005634 hypothetical protein; Provisional; Region: PRK11820 272562005635 YicC-like family, N-terminal region; Region: YicC_N; pfam03755 272562005636 Domain of unknown function (DUF1732); Region: DUF1732; pfam08340 272562005637 hypothetical protein; Provisional; Region: PRK04323 272562005638 Guanylate kinase; Region: Guanylate_kin; pfam00625 272562005639 Guanosine monophosphate kinase (GMPK, EC 2.7.4.8), also known as guanylate kinase (GKase), catalyzes the reversible phosphoryl transfer from adenosine triphosphate (ATP) to guanosine monophosphate (GMP) to yield adenosine diphosphate (ADP) and guanosine...; Region: GMPK; cd00071 272562005640 catalytic site [active] 272562005641 G-X2-G-X-G-K; other site 272562005642 DNA-directed RNA polymerase subunit omega; Reviewed; Region: rpoZ; PRK00392 272562005643 bifunctional phosphopantothenoylcysteine decarboxylase/phosphopantothenate synthase; Validated; Region: PRK05579 272562005644 phosphopantothenoylcysteine decarboxylase; Validated; Region: PRK07313 272562005645 DNA / pantothenate metabolizm flavoprotein; Region: DFP; pfam04127 272562005646 primosome assembly protein PriA; Validated; Region: PRK05580 272562005647 Zinc peptidases M18, M20, M28, and M42; Region: Zinc_peptidase_like; cl14876 272562005648 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 272562005649 ATP binding site [chemical binding]; other site 272562005650 putative Mg++ binding site [ion binding]; other site 272562005651 helicase superfamily c-terminal domain; Region: HELICc; smart00490 272562005652 Polypeptide or peptide deformylase; a family of metalloenzymes that catalyzes the removal of the N-terminal formyl group in a growing polypeptide chain following translation initiation during protein synthesis in prokaryotes. These enzymes utilize Fe(II)...; Region: Pep_deformylase; cd00487 272562005653 active site 272562005654 catalytic residues [active] 272562005655 metal binding site [ion binding]; metal-binding site 272562005656 methionyl-tRNA formyltransferase; Reviewed; Region: fmt; PRK00005 272562005657 Methionyl-tRNA formyltransferase, N-terminal hydrolase domain; Region: FMT_core_Met-tRNA-FMT_N; cd08646 272562005658 putative active site [active] 272562005659 substrate binding site [chemical binding]; other site 272562005660 putative cosubstrate binding site; other site 272562005661 catalytic site [active] 272562005662 C-terminal domain of Formyltransferase and other enzymes; Region: Met_tRNA_FMT_C; cd08704 272562005663 substrate binding site [chemical binding]; other site 272562005664 Predicted Zn-dependent protease [General function prediction only]; Region: COG2738 272562005665 16S rRNA methyltransferase B; Provisional; Region: PRK14902 272562005666 NusB family; Region: NusB; pfam01029 272562005667 putative RNA binding site [nucleotide binding]; other site 272562005668 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl17173 272562005669 Predicted Fe-S-cluster redox enzyme [General function prediction only]; Region: COG0820 272562005670 ribosomal RNA large subunit methyltransferase N; Provisional; Region: PRK14454 272562005671 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 272562005672 FeS/SAM binding site; other site 272562005673 Serine/threonine phosphatases, family 2C, catalytic domain; The protein architecture and deduced catalytic mechanism of PP2C phosphatases are similar to the PP1, PP2A, PP2B family of protein Ser/Thr phosphatases, with which PP2C shares no sequence...; Region: PP2Cc; cd00143 272562005674 active site 272562005675 Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220 272562005676 Catalytic domain of Protein Kinases; Region: PKc; cd00180 272562005677 active site 272562005678 ATP binding site [chemical binding]; other site 272562005679 substrate binding site [chemical binding]; other site 272562005680 activation loop (A-loop); other site 272562005681 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2815 272562005682 PASTA domain of bacterial serine/threonine kinase pknB-like proteins. PknB is a member of a group of related transmembrane sensor kinases present in many gram positive bacteria, which has been shown to regulate cell shape in Mycobacterium tubercolosis; Region: PASTA_pknB; cd06577 272562005683 PASTA domain of bacterial serine/threonine kinase pknB-like proteins. PknB is a member of a group of related transmembrane sensor kinases present in many gram positive bacteria, which has been shown to regulate cell shape in Mycobacterium tubercolosis; Region: PASTA_pknB; cd06577 272562005684 PASTA domain of bacterial serine/threonine kinase pknB-like proteins. PknB is a member of a group of related transmembrane sensor kinases present in many gram positive bacteria, which has been shown to regulate cell shape in Mycobacterium tubercolosis; Region: PASTA_pknB; cd06577 272562005685 GTPase RsgA; Reviewed; Region: PRK00098 272562005686 S1_YloQ_GTPase: YloQ GTase family (also known as YjeQ and CpgA), S1-like RNA-binding domain. Proteins in the YloQ GTase family bind the ribosome and have GTPase activity. The precise role of this family is unknown. The protein structure is composed of...; Region: S1_YloQ_GTPase; cd04466 272562005687 RNA binding site [nucleotide binding]; other site 272562005688 homodimer interface [polypeptide binding]; other site 272562005689 Ribosomal interacting GTPase YjeQ/EngC, a circularly permuted subfamily of the Ras GTPases; Region: YjeQ_EngC; cd01854 272562005690 GTPase/Zn-binding domain interface [polypeptide binding]; other site 272562005691 GTP/Mg2+ binding site [chemical binding]; other site 272562005692 G4 box; other site 272562005693 G5 box; other site 272562005694 G1 box; other site 272562005695 Switch I region; other site 272562005696 G2 box; other site 272562005697 G3 box; other site 272562005698 Switch II region; other site 272562005699 Ribulose-5-phosphate 3-epimerase (RPE). This enzyme catalyses the interconversion of D-ribulose 5-phosphate (Ru5P) into D-xylulose 5-phosphate, as part of the Calvin cycle (reductive pentose phosphate pathway) in chloroplasts and in the oxidative pentose...; Region: RPE; cd00429 272562005700 substrate binding site [chemical binding]; other site 272562005701 hexamer interface [polypeptide binding]; other site 272562005702 metal binding site [ion binding]; metal-binding site 272562005703 Thiamine pyrophosphokinase [Coenzyme metabolism]; Region: THI80; COG1564 272562005704 Thiamine pyrophosphokinase; Region: TPK; cd07995 272562005705 active site 272562005706 dimerization interface [polypeptide binding]; other site 272562005707 thiamine binding site [chemical binding]; other site 272562005708 50S ribosomal protein L28; Reviewed; Region: rpmB; PRK00359 272562005709 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG1302 272562005710 DAK2 domain fusion protein YloV; Region: YloV; TIGR03599 272562005711 DAK2 domain; Region: Dak2; pfam02734 272562005712 Dihydroxyacetone kinase family; Region: Dak1_2; pfam13684 272562005713 ATP-dependent DNA helicase RecG; Provisional; Region: PRK10917 272562005714 RecG_wedge_OBF: A subfamily of OB folds corresponding to the OB fold found in the N-terminal (wedge) domain of Escherichia coli RecG. RecG is a branched-DNA-specific helicase, which catalyzes the interconversion of a DNA replication fork to a...; Region: RecG_wedge_OBF; cd04488 272562005715 ssDNA binding site; other site 272562005716 generic binding surface II; other site 272562005717 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 272562005718 ATP binding site [chemical binding]; other site 272562005719 putative Mg++ binding site [ion binding]; other site 272562005720 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 272562005721 nucleotide binding region [chemical binding]; other site 272562005722 ATP-binding site [chemical binding]; other site 272562005723 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 272562005724 S-adenosylmethionine binding site [chemical binding]; other site 272562005725 Phosphopantetheine adenylyltransferase; Region: PPAT; cd02163 272562005726 active site 272562005727 (T/H)XGH motif; other site 272562005728 phosphodiesterase; Provisional; Region: PRK12704 272562005729 sporulation integral membrane protein YlbJ; Region: spore_ylbJ; TIGR02871 272562005730 Nucleoside recognition; Region: Gate; pfam07670 272562005731 hypothetical protein; Provisional; Region: PRK13670 272562005732 HIGH Nucleotidyl Transferase; Region: HIGH_NTase1; pfam05636 272562005733 phosphotransacetylase; Reviewed; Region: eutD; PRK09653 272562005734 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cd00012 272562005735 nucleotide binding site [chemical binding]; other site 272562005736 butyrate kinase; Provisional; Region: PRK03011 272562005737 50S ribosomal protein L32; Reviewed; Region: rpmF; PRK12286 272562005738 putative phosphate acyltransferase; Provisional; Region: PRK05331 272562005739 acyl carrier protein; Provisional; Region: acpP; PRK00982 272562005740 ribonuclease III; Reviewed; Region: rnc; PRK00102 272562005741 RIBOc. Ribonuclease III C terminal domain. This group consists of eukaryotic, bacterial and archeal ribonuclease III (RNAse III) proteins. RNAse III is a double stranded RNA-specific endonuclease. Prokaryotic RNAse III is important in...; Region: RIBOc; cd00593 272562005742 dimerization interface [polypeptide binding]; other site 272562005743 active site 272562005744 metal binding site [ion binding]; metal-binding site 272562005745 Double-stranded RNA binding motif. Binding is not sequence specific but is highly specific for double stranded RNA. Found in a variety of proteins including dsRNA dependent protein kinase PKR, RNA helicases, Drosophila staufen protein, E. coli RNase III; Region: DSRM; cd00048 272562005746 dsRNA binding site [nucleotide binding]; other site 272562005747 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 272562005748 Radical SAM superfamily; Region: Radical_SAM; pfam04055 272562005749 FeS/SAM binding site; other site 272562005750 Stage V sporulation protein S (SpoVS); Region: SpoVS; pfam04232 272562005751 Chromosome segregation ATPases [Cell division and chromosome partitioning]; Region: Smc; COG1196 272562005752 ATP-binding cassette domain of barmotin, a member of the SMC protein family; Region: ABC_SMC_barmotin; cd03278 272562005753 Walker A/P-loop; other site 272562005754 ATP binding site [chemical binding]; other site 272562005755 Q-loop/lid; other site 272562005756 SMC proteins Flexible Hinge Domain; Region: SMC_hinge; smart00968 272562005757 ATP-binding cassette domain of barmotin, a member of the SMC protein family; Region: ABC_SMC_barmotin; cd03278 272562005758 ABC transporter signature motif; other site 272562005759 Walker B; other site 272562005760 D-loop; other site 272562005761 H-loop/switch region; other site 272562005762 signal recognition particle-docking protein FtsY; Provisional; Region: PRK10416 272562005763 SRP54-type protein, helical bundle domain; Region: SRP54_N; pfam02881 272562005764 SRP54-type protein, GTPase domain; Region: SRP54; smart00962 272562005765 putative DNA-binding protein; Validated; Region: PRK00118 272562005766 signal recognition particle protein; Provisional; Region: PRK10867 272562005767 SRP54-type protein, helical bundle domain; Region: SRP54_N; smart00963 272562005768 The signal recognition particle (SRP) mediates the transport to or across the plasma membrane in bacteria and the endoplasmic reticulum in eukaryotes. SRP recognizes N-terminal sighnal sequences of newly synthesized polypeptides at the ribosome. The...; Region: SRP; cd03115 272562005769 P loop; other site 272562005770 GTP binding site [chemical binding]; other site 272562005771 Signal peptide binding domain; Region: SRP_SPB; pfam02978 272562005772 30S ribosomal protein S16; Reviewed; Region: rpsP; PRK00040 272562005773 hypothetical protein; Provisional; Region: PRK00468 272562005774 G-X-X-G motif; other site 272562005775 16S rRNA-processing protein RimM; Provisional; Region: rimM; PRK00122 272562005776 RimM N-terminal domain; Region: RimM; pfam01782 272562005777 PRC-barrel domain; Region: PRC; pfam05239 272562005778 tRNA (guanine-N(1)-)-methyltransferase; Reviewed; Region: trmD; PRK00026 272562005779 50S ribosomal protein L19; Provisional; Region: rplS; PRK05338 272562005780 signal peptidase I, bacterial type; Region: sigpep_I_bact; TIGR02227 272562005781 The S26 Type I signal peptidase (SPase; LepB; leader peptidase B; leader peptidase I; EC 3.4.21.89) family members are essential membrane-bound serine proteases that function to cleave the amino-terminal signal peptide extension from proteins that are...; Region: S26_SPase_I; cd06530 272562005782 Catalytic site [active] 272562005783 The S24, S26 LexA/signal peptidase superfamily contains LexA-related and type I signal peptidase families. The S24 LexA protein domains include: the lambda repressor CI/C2 family and related bacterial prophage repressor proteins; LexA (EC 3.4.21.88), the...; Region: Peptidase_S24_S26; cl10465 272562005784 GTPase YlqF; Reviewed; Region: rbgA; PRK09563 272562005785 Circularly permuted YlqF GTPase; Region: YlqF; cd01856 272562005786 GTP/Mg2+ binding site [chemical binding]; other site 272562005787 G4 box; other site 272562005788 G5 box; other site 272562005789 50S ribosome-binding GTPase; Region: MMR_HSR1; pfam01926 272562005790 G1 box; other site 272562005791 G1 box; other site 272562005792 GTP/Mg2+ binding site [chemical binding]; other site 272562005793 Switch I region; other site 272562005794 G2 box; other site 272562005795 G2 box; other site 272562005796 Switch I region; other site 272562005797 G3 box; other site 272562005798 G3 box; other site 272562005799 Switch II region; other site 272562005800 Switch II region; other site 272562005801 G4 box; other site 272562005802 Bacterial Ribonuclease HII-like; Region: RNase_HII_bacteria_HII_like; cd07182 272562005803 RNA/DNA hybrid binding site [nucleotide binding]; other site 272562005804 active site 272562005805 hypothetical protein; Reviewed; Region: PRK12497 272562005806 Predicted glutamine amidotransferases [General function prediction only]; Region: COG2071 272562005807 Subgroup of proteins having the Type 1 glutamine amidotransferase (GATase1) domain; Region: GATase1_2; cd01745 272562005808 catalytic triad [active] 272562005809 Predicted ATPase with chaperone activity [Posttranslational modification, protein turnover, chaperones]; Region: COG0606 272562005810 Subunit ChlI of Mg-chelatase; Region: ChlI; pfam13541 272562005811 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 272562005812 Walker A motif; other site 272562005813 ATP binding site [chemical binding]; other site 272562005814 Walker B motif; other site 272562005815 Magnesium chelatase, subunit ChlI; Region: Mg_chelatase_2; pfam13335 272562005816 RNA polymerase factor sigma-70; Validated; Region: PRK06811 272562005817 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 272562005818 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 272562005819 DNA binding residues [nucleotide binding] 272562005820 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3735 272562005821 RNA polymerase sigma-I factor; Region: spore_sigI; TIGR02895 272562005822 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 272562005823 Anti-sigma factor N-terminus; Region: RsgI_N; pfam12791 272562005824 Glycosyl hydrolase family 68, includes levansucrase, beta-fructofuranosidase and inulosucrase; Region: GH68; cd08997 272562005825 active site 272562005826 Beta-fructosidases (levanase/invertase) [Carbohydrate transport and metabolism]; Region: SacC; COG1621 272562005827 Glycosyl hydrolase family 32, beta-fructosidases; Region: GH32_B_Fructosidase; cd08996 272562005828 substrate binding [chemical binding]; other site 272562005829 active site 272562005830 Glycosyl hydrolases family 32 C terminal; Region: Glyco_hydro_32C; pfam08244 272562005831 Glycosyl hydrolase family 68, includes levansucrase, beta-fructofuranosidase and inulosucrase; Region: GH68; cd08997 272562005832 active site 272562005833 Predicted hydrolase (HAD superfamily) [General function prediction only]; Region: COG1011 272562005834 Haloacid dehalogenase superfamily, subfamily IA, variant 2 with 3rd motif like haloacid dehalogenase; Region: HAD-SF-IA-v2; TIGR01493 272562005835 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 272562005836 motif II; other site 272562005837 ADP-ribose pyrophosphatase [Nucleotide transport and metabolism]; Region: COG1051 272562005838 nudix motif; other site 272562005839 Uncharacterized conserved protein [General function prediction only]; Region: COG4111 272562005840 Cysteine hydrolases; This family contains amidohydrolases, like CSHase (N-carbamoylsarcosine amidohydrolase), involved in creatine metabolism and nicotinamidase, converting nicotinamide to nicotinic acid and ammonia in the pyridine nucleotide cycle. It...; Region: cysteine_hydrolases; cd00431 272562005841 catalytic triad [active] 272562005842 conserved cis-peptide bond; other site 272562005843 ABC-2 type transporter; Region: ABC2_membrane; cl17235 272562005844 nicotinate phosphoribosyltransferase; Validated; Region: PRK09243 272562005845 Nicotinate phosphoribosyltransferase (NAPRTase), subgroup A. Nicotinate phosphoribosyltransferase catalyses the formation of NAMN and PPi from 5-phosphoribosy -1-pyrophosphate (PRPP) and nicotinic acid, this is the first, and also rate limiting, reaction...; Region: NAPRTase_A; cd01570 272562005846 active site 272562005847 Nicotinamide/nicotinate mononucleotide adenylyltransferase; Region: NMNAT; cd02165 272562005848 active site 272562005849 (T/H)XGH motif; other site 272562005850 NAD synthetase; Reviewed; Region: nadE; PRK02628 272562005851 Glutamine aminotransferase (GAT, glutaminase) domain of glutamine-dependent NAD synthetases (class 7 and 8 nitrilases); Region: GAT_Gln-NAD-synth; cd07570 272562005852 multimer interface [polypeptide binding]; other site 272562005853 active site 272562005854 catalytic triad [active] 272562005855 protein interface 1 [polypeptide binding]; other site 272562005856 NAD+ synthase is a homodimer, which catalyzes the final step in de novo nicotinamide adenine dinucleotide (NAD+) biosynthesis, an amide transfer from either ammonia or glutamine to nicotinic acid adenine dinucleotide (NaAD). The conversion of NaAD to NAD...; Region: NAD_synthase; cd00553 272562005857 homodimer interface [polypeptide binding]; other site 272562005858 NAD binding pocket [chemical binding]; other site 272562005859 ATP binding pocket [chemical binding]; other site 272562005860 Mg binding site [ion binding]; other site 272562005861 active-site loop [active] 272562005862 Sodium:dicarboxylate symporter family; Region: SDF; cl00573 272562005863 Predicted Rossmann fold nucleotide-binding protein involved in DNA uptake [DNA replication, recombination, and repair / Intracellular trafficking and secretion]; Region: Smf; COG0758 272562005864 DNA recombination-mediator protein A; Region: DNA_processg_A; pfam02481 272562005865 DNA topoisomerase I; Validated; Region: PRK05582 272562005866 TOPRIM_TopoIA_TopoI: The topoisomerase-primase (TORPIM) domain found in members of the type IA family of DNA topoisomerases (Topo IA) similar to Escherichia coli DNA topoisomerase I. Type IA DNA topoisomerases remove (relax) negative supercoils in the...; Region: TOPRIM_TopoIA_TopoI; cd03363 272562005867 active site 272562005868 interdomain interaction site; other site 272562005869 putative metal-binding site [ion binding]; other site 272562005870 nucleotide binding site [chemical binding]; other site 272562005871 DNA Topoisomerase, subtype IA; DNA-binding, ATP-binding and catalytic domain of bacterial DNA topoisomerases I and III, and eukaryotic DNA topoisomerase III and eubacterial and archael reverse gyrases. Topoisomerases clevage single or double stranded DNA...; Region: TOP1Ac; cd00186 272562005872 domain I; other site 272562005873 DNA binding groove [nucleotide binding] 272562005874 phosphate binding site [ion binding]; other site 272562005875 domain II; other site 272562005876 domain III; other site 272562005877 nucleotide binding site [chemical binding]; other site 272562005878 catalytic site [active] 272562005879 domain IV; other site 272562005880 Topoisomerase DNA binding C4 zinc finger; Region: zf-C4_Topoisom; pfam01396 272562005881 Topoisomerase DNA binding C4 zinc finger; Region: zf-C4_Topoisom; pfam01396 272562005882 Topoisomerase DNA binding C4 zinc finger; Region: zf-C4_Topoisom; pfam01396 272562005883 transcriptional repressor CodY; Validated; Region: PRK04158 272562005884 CodY GAF-like domain; Region: CodY; pfam06018 272562005885 CodY helix-turn-helix domain; Region: HTH_CodY; pfam08222 272562005886 Ribosomal protein S2 (RPS2), involved in formation of the translation initiation complex, where it might contact the messenger RNA and several components of the ribosome. It has been shown that in Escherichia coli RPS2 is essential for the binding of...; Region: RPS2; cd01425 272562005887 rRNA interaction site [nucleotide binding]; other site 272562005888 S8 interaction site; other site 272562005889 putative laminin-1 binding site; other site 272562005890 elongation factor Ts; Provisional; Region: tsf; PRK09377 272562005891 UBA/TS-N domain; Region: UBA; pfam00627 272562005892 UMP kinase (UMPK)-Ec, the microbial/chloroplast uridine monophosphate kinase (uridylate kinase) enzyme that catalyzes UMP phosphorylation and plays a key role in pyrimidine nucleotide biosynthesis; regulation of this process is via feed-back control and...; Region: AAK_UMPK-PyrH-Ec; cd04254 272562005893 putative nucleotide binding site [chemical binding]; other site 272562005894 uridine monophosphate binding site [chemical binding]; other site 272562005895 homohexameric interface [polypeptide binding]; other site 272562005896 Ribosome recycling factor (RRF). Ribosome recycling factor dissociates the posttermination complex, composed of the ribosome, deacylated tRNA, and mRNA, after termination of translation. Thus ribosomes are "recycled" and ready for another...; Region: RRF; cd00520 272562005897 hinge region; other site 272562005898 Cis (Z)-Isoprenyl Diphosphate Synthases; Region: Cis_IPPS; cd00475 272562005899 active site 272562005900 dimer interface [polypeptide binding]; other site 272562005901 SOS-response transcriptional repressors (RecA-mediated autopeptidases) [Transcription / Signal transduction mechanisms]; Region: LexA; COG1974 272562005902 Peptidase S24 LexA-like proteins are involved in the SOS response leading to the repair of single-stranded DNA within the bacterial cell. This family includes: the lambda repressor CI/C2 family and related bacterial prophage repressor proteins; LexA (EC...; Region: S24_LexA-like; cd06529 272562005903 Catalytic site [active] 272562005904 Predicted permease, member of the PurR regulon [General function prediction only]; Region: yhhT; COG0628 272562005905 1-deoxy-D-xylulose 5-phosphate reductoisomerase; Provisional; Region: PRK05447 272562005906 1-deoxy-D-xylulose 5-phosphate reductoisomerase; Region: DXP_reductoisom; pfam02670 272562005907 1-deoxy-D-xylulose 5-phosphate reductoisomerase C-terminal; Region: DXP_redisom_C; pfam08436 272562005908 DXP reductoisomerase C-terminal domain; Region: DXPR_C; pfam13288 272562005909 RIP metalloprotease RseP; Region: TIGR00054 272562005910 RseP-like Site-2 proteases (S2P), zinc metalloproteases (MEROPS family M50A), cleave transmembrane domains of substrate proteins, regulating intramembrane proteolysis (RIP) of diverse signal transduction mechanisms. In Escherichia coli, the S2P homolog...; Region: S2P-M50_PDZ_RseP-like; cd06163 272562005911 active site 272562005912 PDZ domain of bacterial and plant zinc metalloprotases, presumably membrane-associated or integral membrane proteases, which may be involved in signalling and regulatory mechanisms. May be responsible for substrate recognition and/or binding, as most PDZ...; Region: PDZ_metalloprotease; cd00989 272562005913 protein binding site [polypeptide binding]; other site 272562005914 putative substrate binding region [chemical binding]; other site 272562005915 4-hydroxy-3-methylbut-2-en-1-yl diphosphate synthase; Reviewed; Region: ispG; PRK00366 272562005916 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate synthase; Region: ispG_gcpE; TIGR00612 272562005917 Sm and related proteins; Region: Sm_like; cl00259 272562005918 Bacillus subtilis YxlS-like, C-terminal domain; Region: YlxS_C; cd01734 272562005919 putative RNA binding site [nucleotide binding]; other site 272562005920 transcription elongation factor NusA; Provisional; Region: nusA; PRK12327 272562005921 NusA N-terminal domain; Region: NusA_N; pfam08529 272562005922 S1_NusA: N-utilizing substance A protein (NusA), S1-like RNA-binding domain. S1-like RNA-binding domains are found in a wide variety of RNA-associated proteins. NusA is a transcription elongation factor containing an N-terminal catalytic domain and three...; Region: S1_NusA; cd04455 272562005923 RNA binding site [nucleotide binding]; other site 272562005924 homodimer interface [polypeptide binding]; other site 272562005925 NusA_K homology RNA-binding domain (KH). NusA is an essential multifunctional transcription elongation factor that is universally conserved among prokaryotes and archaea. NusA anti-termination function plays an important role in the expression of...; Region: NusA_KH; cd02134 272562005926 G-X-X-G motif; other site 272562005927 NusA_K homology RNA-binding domain (KH). NusA is an essential multifunctional transcription elongation factor that is universally conserved among prokaryotes and archaea. NusA anti-termination function plays an important role in the expression of...; Region: NusA_KH; cd02134 272562005928 G-X-X-G motif; other site 272562005929 Ylxr homologs; group of conserved hypothetical bacterial proteins of unknown function; structure revealed putative RNA binding cleft; proteins are encoded by an operon that includes other proteins involved in transcription and/or translation; Region: YlxR; cd00279 272562005930 putative RNA binding cleft [nucleotide binding]; other site 272562005931 ribosomal protein L7Ae family protein; Provisional; Region: PRK05583 272562005932 translation initiation factor IF-2; Validated; Region: infB; PRK05306 272562005933 Translation initiation factor IF-2, N-terminal region; Region: IF2_N; pfam04760 272562005934 Translation initiation factor IF-2, N-terminal region; Region: IF2_N; pfam04760 272562005935 Initiation Factor 2 (IF2)/ eukaryotic Initiation Factor 5B (eIF5B) family; Region: IF2_eIF5B; cd01887 272562005936 G1 box; other site 272562005937 putative GEF interaction site [polypeptide binding]; other site 272562005938 GTP/Mg2+ binding site [chemical binding]; other site 272562005939 Switch I region; other site 272562005940 G2 box; other site 272562005941 G3 box; other site 272562005942 Switch II region; other site 272562005943 G4 box; other site 272562005944 G5 box; other site 272562005945 This family represents the domain II of bacterial Initiation Factor 2 (IF2) and its eukaryotic mitochondrial homologue mtIF2. IF2, the largest initiation factor is an essential GTP binding protein. In E. coli three natural forms of IF2 exist in the cell; Region: IF2_mtIF2_II; cd03702 272562005946 Translation-initiation factor 2; Region: IF-2; pfam11987 272562005947 mtIF2_IVc: this family represents the C2 subdomain of domain IV of mitochondrial translation initiation factor 2 (mtIF2) which adopts a beta-barrel fold displaying a high degree of structural similarity with domain II of the translation elongation factor...; Region: mtIF2_IVc; cd03692 272562005948 ribosome-binding factor A; Validated; Region: rbfA; PRK00521 272562005949 Exopolyphosphatase-related proteins [General function prediction only]; Region: COG0618 272562005950 DHH family; Region: DHH; pfam01368 272562005951 DHHA1 domain; Region: DHHA1; pfam02272 272562005952 tRNA pseudouridine synthase B; Provisional; Region: truB; PRK00130 272562005953 Pseudouridine synthase, Escherichia coli TruB like; Region: PseudoU_synth_EcTruB; cd02573 272562005954 RNA binding site [nucleotide binding]; other site 272562005955 active site 272562005956 bifunctional riboflavin kinase/FMN adenylyltransferase; Reviewed; Region: PRK05627 272562005957 FAD synthetase, N-terminal domain of the bifunctional enzyme; Region: FAD_synthetase_N; cd02064 272562005958 active site 272562005959 Riboflavin kinase; Region: Flavokinase; smart00904 272562005960 Ribosomal protein S15 (prokaryotic)_S13 (eukaryotic) binds the central domain of 16S rRNA and is required for assembly of the small ribosomal subunit and for intersubunit association, thus representing a key element in the assembly of the whole ribosome; Region: Ribosomal_S15p_S13e; cd00353 272562005961 16S/18S rRNA binding site [nucleotide binding]; other site 272562005962 S13e-L30e interaction site [polypeptide binding]; other site 272562005963 25S rRNA binding site [nucleotide binding]; other site 272562005964 polynucleotide phosphorylase/polyadenylase; Provisional; Region: PRK11824 272562005965 Polyribonucleotide nucleotidyltransferase, repeat 1; Region: RNase_PH_PNPase_1; cd11363 272562005966 RNase E interface [polypeptide binding]; other site 272562005967 trimer interface [polypeptide binding]; other site 272562005968 Polyribonucleotide nucleotidyltransferase, RNA binding domain; Region: PNPase; pfam03726 272562005969 Polyribonucleotide nucleotidyltransferase, repeat 2; Region: RNase_PH_PNPase_2; cd11364 272562005970 RNase E interface [polypeptide binding]; other site 272562005971 trimer interface [polypeptide binding]; other site 272562005972 active site 272562005973 Polynucleotide phosphorylase (PNPase) K homology RNA-binding domain (KH). PNPase is a polyribonucleotide nucleotidyl transferase that degrades mRNA in prokaryotes and plant chloroplasts. The C-terminal region of PNPase contains domains homologous to...; Region: PNPase_KH; cd02393 272562005974 putative nucleic acid binding region [nucleotide binding]; other site 272562005975 G-X-X-G motif; other site 272562005976 S1_PNPase: Polynucleotide phosphorylase (PNPase), ), S1-like RNA-binding domain. PNPase is a polyribonucleotide nucleotidyl transferase that degrades mRNA. It is a trimeric multidomain protein. The C-terminus contains the S1 domain which binds ssRNA; Region: S1_PNPase; cd04472 272562005977 RNA binding site [nucleotide binding]; other site 272562005978 domain interface; other site 272562005979 sporulation protein, YlmC/YmxH family; Region: spore_YlmC_YmxH; TIGR02888 272562005980 aspartate kinase I; Reviewed; Region: PRK08210 272562005981 Amino Acid Kinases (AAK) superfamily, catalytic domain; present in such enzymes like N-acetylglutamate kinase (NAGK), carbamate kinase (CK), aspartokinase (AK), glutamate-5-kinase (G5K) and UMP kinase (UMPK). The AAK superfamily includes kinases that...; Region: AAK; cl00452 272562005982 nucleotide binding site [chemical binding]; other site 272562005983 substrate binding site [chemical binding]; other site 272562005984 ACT domains of the diaminopimelate-sensitive aspartokinase (AK) isoenzyme AKI; Region: ACT_AKi-DapG-BS_1; cd04914 272562005985 ACT domains of the diaminopimelate-sensitive aspartokinase (AK) isoenzyme AKI; Region: ACT_AKi-DapG-BS_2; cd04937 272562005986 Protease subunit of ATP-dependent Clp proteases [Posttranslational modification, protein turnover, chaperones / Intracellular trafficking and secretion]; Region: ClpP; COG0740 272562005987 active site 272562005988 DNA segregation ATPase FtsK/SpoIIIE and related proteins [Cell division and chromosome partitioning]; Region: FtsK; COG1674 272562005989 Domain of unknown function (DUF4117); Region: DUF4117; pfam13491 272562005990 FtsK/SpoIIIE family; Region: FtsK_SpoIIIE; pfam01580 272562005991 Bacterial protein of unknown function (DUF885); Region: DUF885; cl19872 272562005992 Ftsk gamma domain; Region: Ftsk_gamma; pfam09397 272562005993 2-methylthioadenine synthetase [Translation, ribosomal structure and biogenesis]; Region: MiaB; COG0621 272562005994 Uncharacterized protein family UPF0004; Region: UPF0004; pfam00919 272562005995 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 272562005996 FeS/SAM binding site; other site 272562005997 CDP-alcohol phosphatidyltransferase; Region: CDP-OH_P_transf; cl00453 272562005998 recombinase A; Provisional; Region: recA; PRK09354 272562005999 RecA is a bacterial enzyme which has roles in homologous recombination, DNA repair, and the induction of the SOS response. RecA couples ATP hydrolysis to DNA strand exchange; Region: recA; cd00983 272562006000 hexamer interface [polypeptide binding]; other site 272562006001 Walker A motif; other site 272562006002 ATP binding site [chemical binding]; other site 272562006003 Walker B motif; other site 272562006004 ribonuclease Y; Region: RNase_Y; TIGR03319 272562006005 F0F1 ATP synthase subunit B; Provisional; Region: PRK14471; cl17192 272562006006 KH domain; Region: KH_1; pfam00013 272562006007 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 272562006008 Zn2+ binding site [ion binding]; other site 272562006009 Mg2+ binding site [ion binding]; other site 272562006010 Stage V sporulation protein S (SpoVS); Region: SpoVS; pfam04232 272562006011 UbiA family of prenyltransferases (PTases), Unknown subgroup; Region: PT_UbiA_2; cd13963 272562006012 putative active site [active] 272562006013 aspartate aminotransferase; Provisional; Region: PRK05764 272562006014 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 272562006015 pyridoxal 5'-phosphate binding site [chemical binding]; other site 272562006016 homodimer interface [polypeptide binding]; other site 272562006017 catalytic residue [active] 272562006018 Histidine-containing phosphocarrier protein (HPr)-like proteins. HPr is a central component of the bacterial phosphoenolpyruvate sugar phosphotransferase system (PTS). The PTS catalyses the phosphorylation of sugar substrates during their translocation...; Region: PTS-HPr_like; cd00367 272562006019 dimerization domain swap beta strand [polypeptide binding]; other site 272562006020 regulatory protein interface [polypeptide binding]; other site 272562006021 active site 272562006022 regulatory phosphorylation site [posttranslational modification]; other site 272562006023 Adenylosuccinate lyase [Nucleotide transport and metabolism]; Region: PurB; COG0015 272562006024 Adenylsuccinate lyase (ASL)_subgroup 2; Region: Adenylsuccinate_lyase_2; cd03302 272562006025 tetramer interface [polypeptide binding]; other site 272562006026 active site 272562006027 Putative peptidoglycan binding domain; Region: PG_binding_1; pfam01471 272562006028 Uncharacterized protein conserved in bacteria [Function unknown]; Region: ErfK; COG1376 272562006029 L,D-transpeptidase catalytic domain; Region: YkuD; pfam03734 272562006030 Uncharacterized conserved protein [Function unknown]; Region: COG2127 272562006031 ATP-dependent Clp protease ATP-binding subunit clpA; Region: ClpA; TIGR02639 272562006032 Clp amino terminal domain; Region: Clp_N; pfam02861 272562006033 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 272562006034 Walker A motif; other site 272562006035 ATP binding site [chemical binding]; other site 272562006036 Walker B motif; other site 272562006037 arginine finger; other site 272562006038 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 272562006039 Walker A motif; other site 272562006040 ATP binding site [chemical binding]; other site 272562006041 Walker B motif; other site 272562006042 C-terminal, D2-small domain, of ClpB protein; Region: ClpB_D2-small; smart01086 272562006043 Type 1 glutamine amidotransferase (GATase1)-like domain found in homoserine trans-succinylase (HTS); Region: GATase1_HTS; cd03131 272562006044 proposed active site lysine [active] 272562006045 conserved cys residue [active] 272562006046 Predicted Zn-dependent proteases and their inactivated homologs [General function prediction only]; Region: TldD; COG0312 272562006047 Predicted Zn-dependent proteases and their inactivated homologs [General function prediction only]; Region: TldD; COG0312 272562006048 LexA repressor; Validated; Region: PRK00215 272562006049 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 272562006050 putative DNA binding site [nucleotide binding]; other site 272562006051 putative Zn2+ binding site [ion binding]; other site 272562006052 Peptidase S24 LexA-like proteins are involved in the SOS response leading to the repair of single-stranded DNA within the bacterial cell. This family includes: the lambda repressor CI/C2 family and related bacterial prophage repressor proteins; LexA (EC...; Region: S24_LexA-like; cd06529 272562006053 Catalytic site [active] 272562006054 Methionine gamma-lyase; Region: Met_gamma_lyase; pfam06838 272562006055 bacterial Hfq-like; Region: Hfq; cd01716 272562006056 hexamer interface [polypeptide binding]; other site 272562006057 Sm1 motif; other site 272562006058 RNA binding site [nucleotide binding]; other site 272562006059 Sm2 motif; other site 272562006060 tRNA delta(2)-isopentenylpyrophosphate transferase; Reviewed; Region: miaA; PRK00091 272562006061 DNA mismatch repair protein; Reviewed; Region: mutL; PRK00095 272562006062 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 272562006063 ATP binding site [chemical binding]; other site 272562006064 Mg2+ binding site [ion binding]; other site 272562006065 G-X-G motif; other site 272562006066 MutL_Trans: transducer domain, having a ribosomal S5 domain 2-like fold, conserved in the C-terminal domain of DNA mismatch repair (MutL/MLH1/PMS2) family. This transducer domain is homologous to the second domain of the DNA gyrase B subunit, which is...; Region: MutL_Trans; cd00782 272562006067 ATP binding site [chemical binding]; other site 272562006068 MutL C terminal dimerization domain; Region: MutL_C; pfam08676 272562006069 DNA mismatch repair protein MutS; Provisional; Region: PRK05399 272562006070 MutS domain I; Region: MutS_I; pfam01624 272562006071 MutS domain II; Region: MutS_II; pfam05188 272562006072 MutS domain III; Region: MutS_III; pfam05192 272562006073 ATP-binding cassette domain of MutS1 homolog; Region: ABC_MutS1; cd03284 272562006074 Walker A/P-loop; other site 272562006075 ATP binding site [chemical binding]; other site 272562006076 Q-loop/lid; other site 272562006077 ABC transporter signature motif; other site 272562006078 Walker B; other site 272562006079 D-loop; other site 272562006080 H-loop/switch region; other site 272562006081 (dimethylallyl)adenosine tRNA methylthiotransferase; Provisional; Region: PRK14328 272562006082 Uncharacterized protein family UPF0004; Region: UPF0004; pfam00919 272562006083 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 272562006084 FeS/SAM binding site; other site 272562006085 TRAM domain; Region: TRAM; pfam01938 272562006086 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 272562006087 Coenzyme A binding pocket [chemical binding]; other site 272562006088 Aminoglycoside 3'-phosphotransferase (APH) and Choline Kinase (ChoK) family. The APH/ChoK family is part of a larger superfamily that includes the catalytic domains of other kinases, such as the typical serine/threonine/tyrosine protein kinases (PKs)...; Region: APH_ChoK_like; cl17270 272562006089 active site 272562006090 ATP binding site [chemical binding]; other site 272562006091 Phage-related holin (Lysis protein) [General function prediction only]; Region: COG4824 272562006092 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 272562006093 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 272562006094 non-specific DNA binding site [nucleotide binding]; other site 272562006095 salt bridge; other site 272562006096 sequence-specific DNA binding site [nucleotide binding]; other site 272562006097 Flagellar motor protein [Cell motility and secretion]; Region: MotB; COG1360 272562006098 Membrane MotB of proton-channel complex MotA/MotB; Region: MotB_plug; pfam13677 272562006099 Peptidoglycan binding domains similar to the C-terminal domain of outer-membrane protein OmpA; Region: OmpA_C-like; cd07185 272562006100 ligand binding site [chemical binding]; other site 272562006101 flagellar motor protein MotA; Validated; Region: PRK08124 272562006102 4-hydroxy-3-methylbut-2-enyl diphosphate reductase/S1 RNA-binding domain protein; Reviewed; Region: PRK00087 272562006103 4-hydroxy-3-methylbut-2-enyl diphosphate reductase; Region: lytB_ispH; cd13944 272562006104 Fe-S cluster binding site [ion binding]; other site 272562006105 substrate binding site [chemical binding]; other site 272562006106 catalytic site [active] 272562006107 S1_RPS1_repeat_ec1_hs1: Ribosomal protein S1 (RPS1) domain. RPS1 is a component of the small ribosomal subunit thought to be involved in the recognition and binding of mRNA's during translation initiation. The bacterial RPS1 domain architecture...; Region: S1_RPS1_repeat_ec1_hs1; cd05687 272562006108 RNA binding site [nucleotide binding]; other site 272562006109 S1_RPS1_repeat_ec2_hs2: Ribosomal protein S1 (RPS1) domain. RPS1 is a component of the small ribosomal subunit thought to be involved in the recognition and binding of mRNA's during translation initiation. The bacterial RPS1 domain architecture...; Region: S1_RPS1_repeat_ec2_hs2; cd04465 272562006110 RNA binding site [nucleotide binding]; other site 272562006111 S1_RPS1_repeat_ec3: Ribosomal protein S1 (RPS1) domain. RPS1 is a component of the small ribosomal subunit thought to be involved in the recognition and binding of mRNA's during translation initiation. The bacterial RPS1 domain architecture consists...; Region: S1_RPS1_repeat_ec3; cd05688 272562006112 RNA binding site [nucleotide binding]; other site 272562006113 S1_like: Ribosomal protein S1-like RNA-binding domain. Found in a wide variety of RNA-associated proteins. Originally identified in S1 ribosomal protein. This superfamily also contains the Cold Shock Domain (CSD), which is a homolog of the S1 domain; Region: S1_like; cl09927 272562006114 RNA binding site [nucleotide binding]; other site 272562006115 cytidylate kinase; Provisional; Region: cmk; PRK00023 272562006116 Cytidine monophosphate kinase (CMPK) catalyzes the reversible phosphorylation of cytidine monophosphate (CMP) to produce cytidine diphosphate (CDP), using ATP as the preferred phosphoryl donor; Region: CMPK; cd02020 272562006117 CMP-binding site; other site 272562006118 The sites determining sugar specificity; other site 272562006119 Predicted flavoproteins [General function prediction only]; Region: COG2081 272562006120 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl19134 272562006121 Transcriptional regulators [Transcription]; Region: RpiR; COG1737 272562006122 Helix-turn-helix domain, rpiR family; Region: HTH_6; pfam01418 272562006123 RpiR-like protein. RpiR contains a SIS (Sugar ISomerase) domain, which is found in many phosphosugar isomerases and phosphosugar binding proteins. In E. coli, rpiR negatively regulates the expression of rpiB gene. Both rpiB and rpiA are ribose phosphate...; Region: SIS_RpiR; cd05013 272562006124 putative active site [active] 272562006125 16S rRNA uridine-516 pseudouridylate synthase and related pseudouridylate synthases [Translation, ribosomal structure and biogenesis]; Region: RsuA; COG1187 272562006126 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 272562006127 RNA binding surface [nucleotide binding]; other site 272562006128 Pseudouridine synthases, RsuA subfamily; Region: PseudoU_synth_RsuA_like; cd02870 272562006129 active site 272562006130 CorA-like Mg2+ transporter protein; Region: CorA; pfam01544 272562006131 Thermotoga maritima CorA_like subfamily; Region: TmCorA-like_1; cd12828 272562006132 oligomer interface [polypeptide binding]; other site 272562006133 metal binding site [ion binding]; metal-binding site 272562006134 metal binding site [ion binding]; metal-binding site 272562006135 Cl binding site [ion binding]; other site 272562006136 aspartate ring; other site 272562006137 basic sphincter; other site 272562006138 putative hydrophobic gate; other site 272562006139 periplasmic entrance; other site 272562006140 ADP-ribose pyrophosphatase (ADPRase) catalyzes the hydrolysis of ADP-ribose and a variety of additional ADP-sugar conjugates to AMP and ribose-5-phosphate. Like other members of the Nudix hydrolase superfamily, it requires a divalent cation, such as Mg2+; Region: ADPRase_NUDT5; cd03424 272562006141 dimer interface [polypeptide binding]; other site 272562006142 ADP-ribose binding site [chemical binding]; other site 272562006143 active site 272562006144 nudix motif; other site 272562006145 metal binding site [ion binding]; metal-binding site 272562006146 Predicted double-stranded RNA/RNA-DNA hybrid binding protein [General function prediction only]; Region: COG3341 272562006147 Bacterial RNase HI containing a hybrid binding domain (HBD) at the N-terminus; Region: RNase_HI_bacteria_like; cd09277 272562006148 RNA/DNA hybrid binding site [nucleotide binding]; other site 272562006149 active site 272562006150 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3864 272562006151 Protein of unknown function (DUF444); Region: DUF444; cl17371 272562006152 Von Willebrand factor type A (vWA) domain was originally found in the blood coagulation protein von Willebrand factor (vWF). Typically, the vWA domain is made up of approximately 200 amino acid residues folded into a classic a/b para-rossmann type of...; Region: vWFA; cl00057 272562006153 metal ion-dependent adhesion site (MIDAS); other site 272562006154 MoxR-like ATPases [General function prediction only]; Region: COG0714 272562006155 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 272562006156 Walker A motif; other site 272562006157 ATP binding site [chemical binding]; other site 272562006158 Walker B motif; other site 272562006159 hypothetical protein; Provisional; Region: PRK05802 272562006160 FAD/NAD binding domain (electron transfer subunit) of dihydroorotate dehydrogenase-like proteins. Dihydroorotate dehydrogenases (DHODs) catalyze the only redox reaction in pyrimidine de novo biosynthesis. They catalyze the oxidation of (S)-dihydroorotate...; Region: DHOD_e_trans_like; cd06192 272562006161 FAD binding pocket [chemical binding]; other site 272562006162 FAD binding motif [chemical binding]; other site 272562006163 phosphate binding motif [ion binding]; other site 272562006164 beta-alpha-beta structure motif; other site 272562006165 NAD binding pocket [chemical binding]; other site 272562006166 Iron coordination center [ion binding]; other site 272562006167 UV radiation resistance protein and autophagy-related subunit 14; Region: Atg14; pfam10186 272562006168 Site-specific recombinases, DNA invertase Pin homologs [DNA replication, recombination, and repair]; Region: PinR; COG1961 272562006169 Serine Recombinase (SR) family, Resolvase and Invertase subfamily, catalytic domain; members contain a C-terminal DNA binding domain. Serine recombinases catalyze site-specific recombination of DNA molecules by a concerted, four-strand cleavage and...; Region: SR_ResInv; cd03768 272562006170 catalytic residues [active] 272562006171 catalytic nucleophile [active] 272562006172 Presynaptic Site I dimer interface [polypeptide binding]; other site 272562006173 Synaptic Antiparallel dimer interface [polypeptide binding]; other site 272562006174 Synaptic Flat tetramer interface [polypeptide binding]; other site 272562006175 Synaptic Site I dimer interface [polypeptide binding]; other site 272562006176 DNA binding site [nucleotide binding] 272562006177 Recombinase; Region: Recombinase; pfam07508 272562006178 Recombinase zinc beta ribbon domain; Region: Zn_ribbon_recom; pfam13408 272562006179 Glucose inhibited division protein A; Region: GIDA; pfam01134 272562006180 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 272562006181 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 272562006182 non-specific DNA binding site [nucleotide binding]; other site 272562006183 salt bridge; other site 272562006184 sequence-specific DNA binding site [nucleotide binding]; other site 272562006185 Protein of unknown function (DUF1510); Region: DUF1510; pfam07423 272562006186 Domain of unknown function (DUF4352); Region: DUF4352; pfam11611 272562006187 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 272562006188 non-specific DNA binding site [nucleotide binding]; other site 272562006189 salt bridge; other site 272562006190 sequence-specific DNA binding site [nucleotide binding]; other site 272562006191 FtsK/SpoIIIE family; Region: FtsK_SpoIIIE; pfam01580 272562006192 ATPases associated with a variety of cellular activities; Region: AAA; smart00382 272562006193 Plasmid rolling circle replication initiator protein and truncated derivatives [DNA replication, recombination, and repair]; Region: COG5655 272562006194 basic leucine zipper DNA-binding and multimerization region of GCN4 and related proteins; Region: B_zip1; cl02576 272562006195 Lyc muramidase is an autolytic lysozyme (autolysin) from Clostridium acetobutylicum encoded by the lyc gene. Lyc has a glycosyl hydrolase family 25 (GH25) catalytic domain. Endo-N-acetylmuramidases are lysozymes (also referred to as peptidoglycan...; Region: GH25_Lyc-like; cd06525 272562006196 Glycosyl hydrolases family 25; Region: Glyco_hydro_25; pfam01183 272562006197 active site 272562006198 Putative peptidoglycan-binding domain-containing protein [Cell envelope biogenesis, outer membrane]; Region: COG3409 272562006199 Putative peptidoglycan binding domain; Region: PG_binding_1; pfam01471 272562006200 Putative peptidoglycan binding domain; Region: PG_binding_1; pfam01471 272562006201 Haemolysin XhlA; Region: XhlA; pfam10779 272562006202 phage minor structural protein, N-terminal region; Region: put_anti_recept; TIGR01665 272562006203 Carbohydrate binding domain; Region: CBM_4_9; pfam02018 272562006204 Chaperone of endosialidase; Region: Peptidase_S74; pfam13884 272562006205 Protein of unknown function (DUF1617); Region: DUF1617; pfam07761 272562006206 Phage-related tail protein [Function unknown]; Region: COG5283 272562006207 polyhydroxyalkanoic acid synthase, PhaR subunit; Region: phaR_Bmeg; TIGR02132 272562006208 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cl19050 272562006209 Lytic Transglycosylase (LT) and Goose Egg White Lysozyme (GEWL) domain. Members include the soluble and insoluble membrane-bound LTs in bacteria, the LTs in bacteriophage lambda, as well as, the eukaryotic "goose-type" lysozymes (GEWL). LTs...; Region: LT_GEWL; cd00254 272562006210 N-acetyl-D-glucosamine binding site [chemical binding]; other site 272562006211 phage major tail protein, phi13 family; Region: maj_tail_phi13; TIGR01603 272562006212 Bacterial Ig-like domain; Region: Big_5; pfam13205 272562006213 phage protein, HK97 gp10 family; Region: phge_HK97_gp10; TIGR01725 272562006214 Bacteriophage head-tail adaptor [General function prediction only]; Region: COG5614 272562006215 Head-Tail Connector Protein gp6 of Bacteriophage HK97 and similar proteins; Region: gp6; cd08054 272562006216 oligomerization interface [polypeptide binding]; other site 272562006217 phage major capsid protein, HK97 family; Region: major_cap_HK97; TIGR01554 272562006218 Phage capsid family; Region: Phage_capsid; pfam05065 272562006219 Caseinolytic protease (ClpP) is an ATP-dependent, highly conserved serine protease; Region: S14_ClpP_1; cd07016 272562006220 oligomer interface [polypeptide binding]; other site 272562006221 active site residues [active] 272562006222 Phage-related protein [Function unknown]; Region: COG4695 272562006223 Phage terminase-like protein, large subunit [General function prediction only]; Region: COG4626 272562006224 Phage Terminase; Region: Terminase_1; cl19862 272562006225 Phage terminase, small subunit [DNA replication, recombination, and repair]; Region: COG3747 272562006226 HNH nucleases; HNH endonuclease signature which is found in viral, prokaryotic, and eukaryotic proteins. The alignment includes members of the large group of homing endonucleases, yeast intron 1 protein, MutS, as well as bacterial colicins, pyocins, and...; Region: HNHc; cd00085 272562006227 active site 272562006228 Mu-like prophage protein Com [General function prediction only]; Region: Com; COG4416 272562006229 Ribonuclease D [Translation, ribosomal structure and biogenesis]; Region: Rnd; COG0349 272562006230 DEDDy 3'-5' exonuclease domain of Ribonuclease D and similar proteins; Region: RNaseD_exo; cd06142 272562006231 catalytic site [active] 272562006232 putative active site [active] 272562006233 putative substrate binding site [chemical binding]; other site 272562006234 Helix-turn-helix domain; Region: HTH_17; pfam12728 272562006235 DNA-directed RNA polymerase, subunit RPC10 (contains C4-type Zn-finger) [Transcription]; Region: RPC10; COG1996 272562006236 DNA-directed RNA polymerase specialized sigma subunit [Transcription]; Region: FliA; COG1191 272562006237 Single-stranded DNA-binding protein [DNA replication, recombination, and repair]; Region: Ssb; COG0629 272562006238 SSB_OBF: A subfamily of OB folds similar to the OB fold of ssDNA-binding protein (SSB). SSBs bind with high affinity to ssDNA. They bind to and protect ssDNA intermediates during DNA metabolic pathways. All bacterial and eukaryotic SSBs studied to date...; Region: SSB_OBF; cd04496 272562006239 dimer interface [polypeptide binding]; other site 272562006240 ssDNA binding site [nucleotide binding]; other site 272562006241 tetramer (dimer of dimers) interface [polypeptide binding]; other site 272562006242 ATP-dependent Lon protease, bacterial type [Posttranslational modification, protein turnover, chaperones]; Region: Lon; COG0466 272562006243 Restriction alleviation protein Lar; Region: Lar_restr_allev; cl08047 272562006244 Nucleoside Triphosphate Pyrophosphohydrolase (EC 3.6.1.8) MazG-like domain found in a group of uncharacterized proteins from bacteria and archaea; Region: NTP-PPase_u5; cd11542 272562006245 metal binding site [ion binding]; metal-binding site 272562006246 Helix-turn-helix domain of Hin and related proteins; Region: HTH_Hin_like; cl17393 272562006247 DNA-binding interface [nucleotide binding]; DNA binding site 272562006248 hypothetical protein; Validated; Region: PRK08116 272562006249 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 272562006250 Walker A motif; other site 272562006251 ATP binding site [chemical binding]; other site 272562006252 Walker B motif; other site 272562006253 N-terminal phage replisome organizer (Phage_rep_org_N); Region: Phage_rep_org_N; pfam09681 272562006254 Coronavirus S2 glycoprotein; Region: Corona_S2; pfam01601 272562006255 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4712 272562006256 Predicted HD-superfamily hydrolase [General function prediction only]; Region: COG3481 272562006257 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 272562006258 Zn2+ binding site [ion binding]; other site 272562006259 Mg2+ binding site [ion binding]; other site 272562006260 Regulators of stationary/sporulation gene expression [Transcription]; Region: AbrB; COG2002 272562006261 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4306 272562006262 Phage anti-repressor protein [Transcription]; Region: COG3561 272562006263 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 272562006264 non-specific DNA binding site [nucleotide binding]; other site 272562006265 salt bridge; other site 272562006266 sequence-specific DNA binding site [nucleotide binding]; other site 272562006267 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 272562006268 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 272562006269 non-specific DNA binding site [nucleotide binding]; other site 272562006270 salt bridge; other site 272562006271 sequence-specific DNA binding site [nucleotide binding]; other site 272562006272 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 272562006273 non-specific DNA binding site [nucleotide binding]; other site 272562006274 salt bridge; other site 272562006275 sequence-specific DNA binding site [nucleotide binding]; other site 272562006276 Tetratricopeptide repeat; Region: TPR_12; pfam13424 272562006277 Predicted transcriptional regulator [Transcription]; Region: COG3655 272562006278 Site-specific recombinases, DNA invertase Pin homologs [DNA replication, recombination, and repair]; Region: PinR; COG1961 272562006279 Serine Recombinase (SR) family, Resolvase and Invertase subfamily, catalytic domain; members contain a C-terminal DNA binding domain. Serine recombinases catalyze site-specific recombination of DNA molecules by a concerted, four-strand cleavage and...; Region: SR_ResInv; cd03768 272562006280 catalytic residues [active] 272562006281 catalytic nucleophile [active] 272562006282 Presynaptic Site I dimer interface [polypeptide binding]; other site 272562006283 Synaptic Antiparallel dimer interface [polypeptide binding]; other site 272562006284 Synaptic Flat tetramer interface [polypeptide binding]; other site 272562006285 Synaptic Site I dimer interface [polypeptide binding]; other site 272562006286 DNA binding site [nucleotide binding] 272562006287 Recombinase; Region: Recombinase; pfam07508 272562006288 Glucose inhibited division protein A; Region: GIDA; pfam01134 272562006289 Membrane protein of unknown function; Region: DUF360; pfam04020 272562006290 Uncharacterized conserved small protein [Function unknown]; Region: COG5515 272562006291 Site-specific recombinases, DNA invertase Pin homologs [DNA replication, recombination, and repair]; Region: PinR; COG1961 272562006292 Serine Recombinase (SR) family, Resolvase and Invertase subfamily, catalytic domain; members contain a C-terminal DNA binding domain. Serine recombinases catalyze site-specific recombination of DNA molecules by a concerted, four-strand cleavage and...; Region: SR_ResInv; cd03768 272562006293 catalytic residues [active] 272562006294 catalytic nucleophile [active] 272562006295 Presynaptic Site I dimer interface [polypeptide binding]; other site 272562006296 Synaptic Antiparallel dimer interface [polypeptide binding]; other site 272562006297 Synaptic Flat tetramer interface [polypeptide binding]; other site 272562006298 Synaptic Site I dimer interface [polypeptide binding]; other site 272562006299 DNA binding site [nucleotide binding] 272562006300 Recombinase; Region: Recombinase; pfam07508 272562006301 Recombinase zinc beta ribbon domain; Region: Zn_ribbon_recom; pfam13408 272562006302 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 272562006303 active site 272562006304 catalytic tetrad [active] 272562006305 Protein of unknown function (DUF1256); Region: DUF1256; pfam06866 272562006306 Protein of unknown function (DUF1256); Region: DUF1256; pfam06866 272562006307 Saccharomyces cerevisiae DCR2 phosphatase and related proteins, metallophosphatase domain; Region: MPP_Dcr2; cd07383 272562006308 Predicted phosphohydrolases [General function prediction only]; Region: Icc; COG1409 272562006309 putative active site [active] 272562006310 putative metal binding site [ion binding]; other site 272562006311 Predicted hydrolase of the alpha/beta superfamily [General function prediction only]; Region: COG2819 272562006312 5'-nucleotidase/2',3'-cyclic phosphodiesterase and related esterases [Nucleotide transport and metabolism]; Region: UshA; COG0737 272562006313 Escherichia coli CpdB and related proteins, N-terminal metallophosphatase domain; Region: MPP_CpdB_N; cd07410 272562006314 active site 272562006315 metal binding site [ion binding]; metal-binding site 272562006316 5'-nucleotidase, C-terminal domain; Region: 5_nucleotid_C; pfam02872 272562006317 Ribosomal protein S1 [Translation, ribosomal structure and biogenesis]; Region: RpsA; COG0539 272562006318 Ribosomal protein S1-like RNA-binding domain; Region: S1; smart00316 272562006319 transcription elongation factor GreA; Region: greA; TIGR01462 272562006320 Transcription elongation factor, N-terminal; Region: GreA_GreB_N; pfam03449 272562006321 Transcription elongation factor, GreA/GreB, C-term; Region: GreA_GreB; pfam01272 272562006322 Pectate lyase superfamily protein; Region: Pectate_lyase_3; cl19188 272562006323 Right handed beta helix region; Region: Beta_helix; pfam13229 272562006324 Pectate lyase superfamily protein; Region: Pectate_lyase_3; cl19188 272562006325 Type IV secretory pathway, VirD4 components [Intracellular trafficking and secretion]; Region: VirD4; COG3505 272562006326 The TraG/TraD/VirD4 family are bacterial conjugation proteins involved in type IV secretion. These proteins aid the transfer of DNA from the plasmid into the host bacterial chromosome. They contain an ATP binding domain. VirD4 is involved in DNA transfer...; Region: TraG_VirD4; cd01126 272562006327 Walker A motif; other site 272562006328 ATP binding site [chemical binding]; other site 272562006329 Walker B motif; other site 272562006330 Type IV leader peptidase family; Region: Peptidase_A24; pfam01478 272562006331 SAF domains of the flagella basal body P-ring formation protein FlgA and the flp pilus assembly CpaB; Region: SAF_CpaB_FlgA_like; cd11614 272562006332 Flp pilus assembly protein TadC [Cell motility and secretion / Intracellular trafficking and secretion]; Region: TadC; COG2064 272562006333 Flp pilus assembly protein, ATPase CpaF [Intracellular trafficking and secretion]; Region: CpaF; COG4962 272562006334 Walker A motif; other site 272562006335 ATP binding site [chemical binding]; other site 272562006336 Walker B motif; other site 272562006337 The Fer4_NifH superfamily contains a variety of proteins which share a common ATP-binding domain. Functionally, proteins in this superfamily use the energy from hydrolysis of NTP to transfer electron or ion; Region: Fer4_NifH; cl17203 272562006338 Permeases of the drug/metabolite transporter (DMT) superfamily [Carbohydrate transport and metabolism / Amino acid transport and metabolism / General function prediction only]; Region: RhaT; COG0697 272562006339 EamA-like transporter family; Region: EamA; pfam00892 272562006340 Protein of unknown function (DUF2786); Region: DUF2786; pfam10979 272562006341 ABC-type Fe3+-hydroxamate transport system, periplasmic component [Inorganic ion transport and metabolism]; Region: FepB; COG0614 272562006342 Periplasmic binding protein TroA_e. These proteins are predicted to function as initial receptors in the ABC metal ion uptake in eubacteria and archaea. They belong to the TroA superfamily of helical backbone metal receptor proteins that share a...; Region: TroA_e; cd01142 272562006343 putative ligand binding residues [chemical binding]; other site 272562006344 ABC-type cobalamin/Fe3+-siderophores transport systems, ATPase components [Inorganic ion transport and metabolism / Coenzyme metabolism]; Region: FepC; COG1120 272562006345 ATP-binding component of iron-siderophores, vitamin B12 and hemin transporters and related proteins; Region: ABC_Iron-Siderophores_B12_Hemin; cd03214 272562006346 Walker A/P-loop; other site 272562006347 ATP binding site [chemical binding]; other site 272562006348 Q-loop/lid; other site 272562006349 ABC transporter signature motif; other site 272562006350 Walker B; other site 272562006351 D-loop; other site 272562006352 H-loop/switch region; other site 272562006353 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550 272562006354 ABC-ATPase subunit interface; other site 272562006355 dimer interface [polypeptide binding]; other site 272562006356 putative PBP binding regions; other site 272562006357 MOSC domain; Region: MOSC; pfam03473 272562006358 MoaC family, prokaryotic and eukaryotic. Members of this family are involved in molybdenum cofactor (Moco) biosynthesis, an essential cofactor of a diverse group of redox enzymes. MoaC, a small hexameric protein, converts, together with MoaA, a guanosine...; Region: MoaC_PE; cd01420 272562006359 trimer interface [polypeptide binding]; other site 272562006360 dimer interface [polypeptide binding]; other site 272562006361 putative active site [active] 272562006362 molybdenum cofactor biosynthesis protein A, bacterial; Region: moaA; TIGR02666 272562006363 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 272562006364 FeS/SAM binding site; other site 272562006365 Molybdenum Cofactor Synthesis C; Region: Mob_synth_C; pfam06463 272562006366 MogA_MoaB family. Members of this family are involved in biosynthesis of the molybdenum cofactor (MoCF) an essential cofactor of a diverse group of redox enzymes. MoCF biosynthesis is an evolutionarily conserved pathway present in eubacteria, archaea; Region: MogA_MoaB; cd00886 272562006367 MPT binding site; other site 272562006368 trimer interface [polypeptide binding]; other site 272562006369 Glycosyl transferases, related to UDP-glucuronosyltransferase [Carbohydrate transport and metabolism / Signal transduction mechanisms]; Region: COG1819 272562006370 Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013 272562006371 ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136 272562006372 ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255 272562006373 Walker A/P-loop; other site 272562006374 ATP binding site [chemical binding]; other site 272562006375 Q-loop/lid; other site 272562006376 ABC transporter signature motif; other site 272562006377 Walker B; other site 272562006378 D-loop; other site 272562006379 H-loop/switch region; other site 272562006380 indolepyruvate oxidoreductase subunit beta; Reviewed; Region: PRK06853 272562006381 indolepyruvate ferredoxin oxidoreductase, alpha subunit; Region: IOR_alpha; TIGR03336 272562006382 Pyrimidine (PYR) binding domain of pyruvate ferredoxin oxidoreductase (PFOR), indolepyruvate ferredoxin oxidoreductase alpha subunit (IOR-alpha), and related proteins; Region: TPP_PYR_PFOR_IOR-alpha_like; cd07034 272562006383 dimer interface [polypeptide binding]; other site 272562006384 PYR/PP interface [polypeptide binding]; other site 272562006385 TPP binding site [chemical binding]; other site 272562006386 substrate binding site [chemical binding]; other site 272562006387 Thiamine pyrophosphate (TPP) family, IOR-alpha subfamily, TPP-binding module; composed of proteins similar to indolepyruvate ferredoxin oxidoreductase (IOR) alpha subunit. IOR catalyzes the oxidative decarboxylation of arylpyruvates, such as...; Region: TPP_IOR_alpha; cd02008 272562006388 TPP-binding site; other site 272562006389 4Fe-4S single cluster domain; Region: Fer4_15; pfam13459 272562006390 NADPH-dependent FMN reductase; Region: FMN_red; pfam03358 272562006391 Multimeric flavodoxin WrbA [General function prediction only]; Region: WrbA; COG0655 272562006392 ABC-type transport system, involved in lipoprotein release, permease component [Cell envelope biogenesis, outer membrane]; Region: LolE; COG4591 272562006393 MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704 272562006394 FtsX-like permease family; Region: FtsX; pfam02687 272562006395 MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704 272562006396 ABC-type transport system, involved in lipoprotein release, permease component [Cell envelope biogenesis, outer membrane]; Region: LolE; COG4591 272562006397 FtsX-like permease family; Region: FtsX; pfam02687 272562006398 Uncharacterized protein containing a NRPS condensation (elongation) domain [General function prediction only]; Region: COG4908 272562006399 Uncharacterized protein containing a NRPS condensation (elongation) domain [General function prediction only]; Region: COG4908 272562006400 Phosphopantetheinyl transferase [Coenzyme metabolism]; Region: Sfp; COG2091 272562006401 4'-phosphopantetheinyl transferase superfamily; Region: ACPS; pfam01648 272562006402 Glycosyl transferases, related to UDP-glucuronosyltransferase [Carbohydrate transport and metabolism / Signal transduction mechanisms]; Region: COG1819 272562006403 Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013 272562006404 beta-ketoacyl-acyl-carrier-protein synthase II; Region: fabF; TIGR03150 272562006405 Beta-ketoacyl-acyl carrier protein (ACP) synthase (KAS), type I and II. KASs are responsible for the elongation steps in fatty acid biosynthesis. KASIII catalyses the initial condensation and KAS I and II catalyze further elongation steps by Claisen...; Region: KAS_I_II; cd00834 272562006406 dimer interface [polypeptide binding]; other site 272562006407 active site 272562006408 3-hydroxyacyl-CoA dehydrogenase [Lipid metabolism]; Region: FadB; COG1250 272562006409 3-hydroxyacyl-CoA dehydrogenase, NAD binding domain; Region: 3HCDH_N; pfam02737 272562006410 Fe-S oxidoreductase [Energy production and conversion]; Region: COG1032 272562006411 B12 binding domain_like associated with radical SAM domain. This domain shows similarity with B12 (adenosylcobamide) binding domains found in several enzymes, such as glutamate mutase, methionine synthase and methylmalonyl-CoA mutase, but it lacks the...; Region: radical_SAM_B12_BD; cd02068 272562006412 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 272562006413 FeS/SAM binding site; other site 272562006414 3-oxoacyl-[acyl-carrier-protein]; Region: FabH; COG0332 272562006415 "initiating" condensing enzymes are a subclass of decarboxylating condensing enzymes, including beta-ketoacyl [ACP] synthase, type III and polyketide synthases, type III, which include chalcone synthase and related enzymes. They are...; Region: init_cond_enzymes; cd00827 272562006416 dimer interface [polypeptide binding]; other site 272562006417 active site 272562006418 Enoyl-CoA hydratase/carnithine racemase [Lipid metabolism]; Region: CaiD; COG1024 272562006419 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 272562006420 substrate binding site [chemical binding]; other site 272562006421 oxyanion hole (OAH) forming residues; other site 272562006422 trimer interface [polypeptide binding]; other site 272562006423 4-hydroxybenzoyl-CoA thioesterase (4HBT). Catalyzes the final step in the 4-chlorobenzoate degradation pathway in which 4-chlorobenzoate is converted to 4-hydroxybenzoate in certain soil-dwelling bacteria. 4HBT forms a homotetramer with four active sites; Region: 4HBT; cd00586 272562006424 active site 272562006425 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 272562006426 Enoyl-CoA hydratase/isomerase family; Region: ECH; pfam00378 272562006427 substrate binding site [chemical binding]; other site 272562006428 oxyanion hole (OAH) forming residues; other site 272562006429 trimer interface [polypeptide binding]; other site 272562006430 Acyl carrier protein [Lipid metabolism / Secondary metabolites biosynthesis, transport, and catabolism]; Region: AcpP; COG0236 272562006431 Aldehyde:ferredoxin oxidoreductase [Energy production and conversion]; Region: COG2414 272562006432 Aldehyde ferredoxin oxidoreductase, N-terminal domain; Region: AFOR_N; smart00790 272562006433 Aldehyde ferredoxin oxidoreductase, domains 2 & 3; Region: AFOR_C; pfam01314 272562006434 (acyl-carrier-protein) S-malonyltransferase [Lipid metabolism]; Region: FabD; COG0331 272562006435 putative molybdopterin biosynthesis protein MoeA/LysR substrate binding-domain-containing protein; Provisional; Region: PRK14498 272562006436 MoeA family. Members of this family are involved in biosynthesis of the molybdenum cofactor (MoCF), an essential cofactor of a diverse group of redox enzymes. MoCF biosynthesis is an evolutionarily conserved pathway present in eubacteria, archaea and...; Region: MoeA; cd00887 272562006437 dimer interface [polypeptide binding]; other site 272562006438 putative functional site; other site 272562006439 putative MPT binding site; other site 272562006440 Periplasmic molybdate-binding protein/domain [Inorganic ion transport and metabolism]; Region: COG1910 272562006441 Molybdopterin biosynthesis enzyme [Coenzyme metabolism]; Region: MoeA; COG0303 272562006442 MoeA family. Members of this family are involved in biosynthesis of the molybdenum cofactor (MoCF), an essential cofactor of a diverse group of redox enzymes. MoCF biosynthesis is an evolutionarily conserved pathway present in eubacteria, archaea and...; Region: MoeA; cd00887 272562006443 dimer interface [polypeptide binding]; other site 272562006444 putative functional site; other site 272562006445 putative MPT binding site; other site 272562006446 MogA_MoaB family. Members of this family are involved in biosynthesis of the molybdenum cofactor (MoCF) an essential cofactor of a diverse group of redox enzymes. MoCF biosynthesis is an evolutionarily conserved pathway present in eubacteria, archaea; Region: MogA_MoaB; cd00886 272562006447 MPT binding site; other site 272562006448 trimer interface [polypeptide binding]; other site 272562006449 START/RHO_alpha_C/PITP/Bet_v1/CoxG/CalC (SRPBCC) ligand-binding domain superfamily; Region: SRPBCC; cl14643 272562006450 hydrophobic ligand binding site; other site 272562006451 Flavodoxins [Energy production and conversion]; Region: FldA; COG0716 272562006452 Protein of unknown function (DUF4237); Region: DUF4237; pfam14021 272562006453 Preprotein translocase subunit; Region: YajC; cl00806 272562006454 ABC-type multidrug transport system, ATPase component [Defense mechanisms]; Region: CcmA; COG1131 272562006455 ATP-binding cassette domain of the bacitracin-resistance transporter; Region: ABC_BcrA_bacitracin_resist; cd03268 272562006456 Walker A/P-loop; other site 272562006457 ATP binding site [chemical binding]; other site 272562006458 Q-loop/lid; other site 272562006459 ABC transporter signature motif; other site 272562006460 Walker B; other site 272562006461 D-loop; other site 272562006462 H-loop/switch region; other site 272562006463 ABC-type transport system involved in multi-copper enzyme maturation, permease component [General function prediction only]; Region: NosY; COG1277 272562006464 ABC-2 family transporter protein; Region: ABC2_membrane_4; pfam12730 272562006465 NfeD-like C-terminal, partner-binding; Region: NfeD; cl00686 272562006466 Peptidase_C39 like family; Region: Peptidase_C39_2; pfam13529 272562006467 putative active site [active] 272562006468 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3584 272562006469 AAA-like domain; Region: AAA_10; pfam12846 272562006470 PrgI family protein; Region: PrgI; pfam12666 272562006471 RNA polymerase sigma-F factor; Region: spore_sigF; TIGR02885 272562006472 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 272562006473 Winged helix-turn helix; Region: HTH_29; pfam13551 272562006474 RNA polymerase sigma factor, sigma-70 family; Region: sigma70-ECF; TIGR02937 272562006475 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 272562006476 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 272562006477 non-specific DNA binding site [nucleotide binding]; other site 272562006478 salt bridge; other site 272562006479 sequence-specific DNA binding site [nucleotide binding]; other site 272562006480 D-alanyl-D-alanine carboxypeptidase [Cell envelope biogenesis, outer membrane]; Region: DacC; COG1686 272562006481 Beta-lactamase enzyme family; Region: Beta-lactamase2; cl19191 272562006482 Penicillin-binding protein 5, C-terminal domain; Region: PBP5_C; pfam07943 272562006483 Protein of unknown function (DUF2953); Region: DUF2953; pfam11167 272562006484 sporulation protein YtfJ; Region: spore_ytfJ; TIGR02874 272562006485 LemA family; Region: LemA; cl00742 272562006486 segregation and condensation protein B; Reviewed; Region: scpB; PRK00135 272562006487 segregation and condensation protein A; Reviewed; Region: scpA; PRK00104 272562006488 tRNA nucleotidyltransferase/poly(A) polymerase [Translation, ribosomal structure and biogenesis]; Region: PcnB; COG0617 272562006489 Nucleotidyltransferase (NT) domain of ClassII CCA-adding enzymes; Region: NT_ClassII-CCAase; cd05398 272562006490 active site 272562006491 NTP binding site [chemical binding]; other site 272562006492 metal binding triad [ion binding]; metal-binding site 272562006493 D-alanyl-D-alanine carboxypeptidase [Cell envelope biogenesis, outer membrane]; Region: DacC; COG1686 272562006494 Beta-lactamase enzyme family; Region: Beta-lactamase2; cl19191 272562006495 Penicillin-binding protein 5, C-terminal domain; Region: PBP5_C; pfam07943 272562006496 purine nucleoside phosphorylase; Provisional; Region: PRK08202 272562006497 Purine nucleoside phosphorylase [Nucleotide transport and metabolism]; Region: Pnp; COG0005 272562006498 phosphopentomutase; Provisional; Region: PRK05362 272562006499 XerD and XerC integrases, DNA breaking-rejoining enzymes, N- and C-terminal domains. XerD-like integrases are involved in the site-specific integration and excision of lysogenic bacteriophage genomes, transposition of conjugative transposons, termination...; Region: INT_XerDC; cd00798 272562006500 tyrosine recombinase XerD; Region: recomb_XerD; TIGR02225 272562006501 active site 272562006502 Int/Topo IB signature motif; other site 272562006503 stage II sporulation protein M; Region: spo_II_M; TIGR02831 272562006504 sporulation transcription factor Spo0A; Region: spore_0_A; TIGR02875 272562006505 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 272562006506 active site 272562006507 phosphorylation site [posttranslational modification] 272562006508 intermolecular recognition site; other site 272562006509 dimerization interface [polypeptide binding]; other site 272562006510 Sporulation initiation factor Spo0A C terminal; Region: Spo0A_C; pfam08769 272562006511 stage IV sporulation protein B; Region: spore_IV_B; TIGR02860 272562006512 PDZ domain of bacterial and plant zinc metalloprotases, presumably membrane-associated or integral membrane proteases, which may be involved in signalling and regulatory mechanisms. May be responsible for substrate recognition and/or binding, as most PDZ...; Region: PDZ_metalloprotease; cd00989 272562006513 protein binding site [polypeptide binding]; other site 272562006514 SpoIVB peptidase S55; Region: Peptidase_S55; pfam05580 272562006515 ATPase involved in DNA repair [DNA replication, recombination, and repair]; Region: RecN; COG0497 272562006516 ATP-binding cassette domain of RecN; Region: ABC_RecN; cd03241 272562006517 Walker A/P-loop; other site 272562006518 ATP binding site [chemical binding]; other site 272562006519 Q-loop/lid; other site 272562006520 ATP-binding cassette domain of RecN; Region: ABC_RecN; cd03241 272562006521 ABC transporter signature motif; other site 272562006522 Walker B; other site 272562006523 D-loop; other site 272562006524 H-loop/switch region; other site 272562006525 arginine repressor; Provisional; Region: argR; PRK00441 272562006526 Arginine repressor, DNA binding domain; Region: Arg_repressor; pfam01316 272562006527 Arginine repressor, C-terminal domain; Region: Arg_repressor_C; pfam02863 272562006528 NAD kinase [Coenzyme metabolism]; Region: nadF; COG0061 272562006529 Predicted rRNA methylase [Translation, ribosomal structure and biogenesis]; Region: COG1189 272562006530 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 272562006531 RNA binding surface [nucleotide binding]; other site 272562006532 FtsJ-like methyltransferase; Region: FtsJ; pfam01728 272562006533 Deoxyxylulose-5-phosphate synthase [Coenzyme metabolism / Lipid metabolism]; Region: Dxs; COG1154 272562006534 Thiamine pyrophosphate (TPP) family, DXS subfamily, TPP-binding module; 1-Deoxy-D-xylulose-5-phosphate synthase (DXS) is a regulatory enzyme of the mevalonate-independent pathway involved in terpenoid biosynthesis. Terpeniods are plant natural products...; Region: TPP_DXS; cd02007 272562006535 TPP-binding site; other site 272562006536 Pyrimidine (PYR) binding domain of 1-deoxy-D-xylulose-5-phosphate synthase (DXS), transketolase (TK), and related proteins; Region: TPP_PYR_DXS_TK_like; cd07033 272562006537 PYR/PP interface [polypeptide binding]; other site 272562006538 dimer interface [polypeptide binding]; other site 272562006539 TPP binding site [chemical binding]; other site 272562006540 Transketolase, C-terminal domain; Region: Transketolase_C; pfam02780 272562006541 Trans-Isoprenyl Diphosphate Synthases, head-to-tail; Region: Trans_IPPS_HT; cd00685 272562006542 substrate binding pocket [chemical binding]; other site 272562006543 chain length determination region; other site 272562006544 substrate-Mg2+ binding site; other site 272562006545 catalytic residues [active] 272562006546 aspartate-rich region 1; other site 272562006547 active site lid residues [active] 272562006548 aspartate-rich region 2; other site 272562006549 exodeoxyribonuclease VII small subunit; Provisional; Region: PRK00977 272562006550 Exonuclease VII, large subunit [DNA replication, recombination, and repair]; Region: XseA; COG1570 272562006551 ExoVII_LU_OBF: A subfamily of OB folds corresponding to the N-terminal OB-fold domain of Escherichia coli exodeoxyribonuclease VII (ExoVII) large subunit. E. coli ExoVII is composed of two non-identical subunits. E. coli ExoVII is a...; Region: ExoVII_LU_OBF; cd04489 272562006552 generic binding surface I; other site 272562006553 generic binding surface II; other site 272562006554 bifunctional 5,10-methylene-tetrahydrofolate dehydrogenase/ 5,10-methylene-tetrahydrofolate cyclohydrolase; Provisional; Region: PRK14172 272562006555 Tetrahydrofolate dehydrogenase/cyclohydrolase, catalytic domain; Region: THF_DHG_CYH; pfam00763 272562006556 NADP binding domain of methylene-tetrahydrofolate dehydrogenase/cyclohydrolase; Region: NAD_bind_m-THF_DH_Cyclohyd; cd01080 272562006557 homodimer interface [polypeptide binding]; other site 272562006558 NADP binding site [chemical binding]; other site 272562006559 substrate binding site [chemical binding]; other site 272562006560 transcription antitermination protein NusB; Reviewed; Region: nusB; PRK00202 272562006561 putative RNA binding site [nucleotide binding]; other site 272562006562 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG1302 272562006563 SpoIIIAH-like protein; Region: SpoIIIAH; pfam12685 272562006564 stage III sporulation protein AG; Region: spore_III_AG; TIGR02830 272562006565 Stage III sporulation protein AF (Spore_III_AF); Region: Spore_III_AF; pfam09581 272562006566 stage III sporulation protein AE; Region: spore_III_AE; TIGR02829 272562006567 stage III sporulation protein AD; Region: spore_III_AD; TIGR02849 272562006568 stage III sporulation protein AC; Region: spore_III_AC; TIGR02848 272562006569 stage III sporulation protein AB; Region: spore_III_AB; TIGR02833 272562006570 stage III sporulation protein AA; Region: spore_III_AA; TIGR02858 272562006571 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 272562006572 Walker A motif; other site 272562006573 ATP binding site [chemical binding]; other site 272562006574 Walker B motif; other site 272562006575 elongation factor P; Validated; Region: PRK00529 272562006576 Elongation factor P (EF-P) KOW-like domain; Region: EFP_N; pfam08207 272562006577 S1_EF-P_repeat_1: Translation elongation factor P (EF-P), S1-like RNA-binding domain, repeat 1. EF-P stimulates the peptidyltransferase activity in the prokaryotic 70S ribosome. EF-P enhances the synthesis of certain dipeptides with...; Region: S1_EF-P_repeat_1; cd04470 272562006578 RNA binding site [nucleotide binding]; other site 272562006579 S1_EF-P_repeat_2: Translation elongation factor P (EF-P), S1-like RNA-binding domain, repeat 1. EF-P stimulates the peptidyltransferase activity in the prokaryotic 70S ribosome. EF-P enhances the synthesis of certain dipeptides with...; Region: S1_EF-P_repeat_2; cd05794 272562006580 RNA binding site [nucleotide binding]; other site 272562006581 Xaa-Pro aminopeptidase [Amino acid transport and metabolism]; Region: PepP; COG0006 272562006582 Creatinase/Prolidase N-terminal domain; Region: Creatinase_N; pfam01321 272562006583 Similar to Prolidase and Aminopeptidase P. The members of this subfamily presumably catalyse hydrolysis of Xaa-Pro dipeptides and/or release of any N-terminal amino acid, including proline, that is linked with proline; Region: APP-like; cd01092 272562006584 active site 272562006585 Type II secretory pathway, pseudopilin PulG [Cell motility and secretion / Intracellular trafficking and secretion]; Region: PulG; COG2165 272562006586 prepilin-type N-terminal cleavage/methylation domain; Region: IV_pilin_GFxxxE; TIGR02532 272562006587 Type II secretory pathway, pseudopilin PulG [Cell motility and secretion / Intracellular trafficking and secretion]; Region: PulG; COG2165 272562006588 Prokaryotic N-terminal methylation motif; Region: N_methyl; pfam07963 272562006589 Type II secretory pathway, pseudopilin PulG [Cell motility and secretion / Intracellular trafficking and secretion]; Region: PulG; COG2165 272562006590 Type II secretory pathway, pseudopilin PulG [Cell motility and secretion / Intracellular trafficking and secretion]; Region: PulG; COG2165 272562006591 prepilin-type N-terminal cleavage/methylation domain; Region: IV_pilin_GFxxxE; TIGR02532 272562006592 Type II secretory pathway, component PulF [Cell motility and secretion / Intracellular trafficking and secretion]; Region: PulF; COG1459 272562006593 Type II secretion system (T2SS), protein F; Region: T2SF; pfam00482 272562006594 Type II secretion system (T2SS), protein F; Region: T2SF; pfam00482 272562006595 Type II secretory pathway, ATPase PulE/Tfp pilus assembly pathway, ATPase PilB [Cell motility and secretion / Intracellular trafficking and secretion]; Region: PulE; COG2804 272562006596 PulE/GspE The type II secretory pathway is the main terminal branch of the general secretory pathway (GSP). It is responsible for the export the majority of Gram-negative bacterial exoenzymes and toxins. PulE is a cytoplasmic protein of the GSP, which...; Region: PulE-GspE; cd01129 272562006597 Walker A motif; other site 272562006598 ATP binding site [chemical binding]; other site 272562006599 Walker B motif; other site 272562006600 Bacterial surface proteins containing Ig-like domains [Cell motility and secretion]; Region: COG5492 272562006601 Bacterial Ig-like domain (group 2); Region: Big_2; pfam02368 272562006602 Bacterial Ig-like domain (group 2); Region: Big_2; pfam02368 272562006603 GAF domain-containing protein [Signal transduction mechanisms]; Region: COG1956 272562006604 Predicted RNA-binding protein homologous to eukaryotic snRNP [Transcription]; Region: COG1293 272562006605 Domain of unknown function (DUF814); Region: DUF814; pfam05670 272562006606 Xanthine/uracil permeases [Nucleotide transport and metabolism]; Region: UraA; COG2233 272562006607 Sulfate transporter family; Region: Sulfate_transp; cl19250 272562006608 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 272562006609 active site 272562006610 pseudouridine synthase, RluA family; Region: rluA_subfam; TIGR00005 272562006611 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 272562006612 RNA binding surface [nucleotide binding]; other site 272562006613 Pseudouridine synthase, RsuA/RluD family; Region: PseudoU_synth_RluCD_like; cd02869 272562006614 active site 272562006615 lipoprotein signal peptidase; Provisional; Region: PRK14791 272562006616 regulatory protein, yteA family; Region: bacill_yteA; TIGR02890 272562006617 5'-methylthioadenosine/S-adenosylhomocysteine nucleosidase; Validated; Region: PRK05584 272562006618 Cell division initiation protein [Cell division and chromosome partitioning]; Region: DivIVA; COG3599 272562006619 DivIVA protein; Region: DivIVA; pfam05103 272562006620 Predicted integral membrane protein [Function unknown]; Region: COG0762 272562006621 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG1799 272562006622 Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzymes, YBL036c-like proteins; Region: PLPDE_III_YBL036c_like; cd00635 272562006623 pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site 272562006624 catalytic residue [active] 272562006625 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3879 272562006626 Uncharacterized conserved protein (small basic protein) [Function unknown]; Region: Sbp; COG3856 272562006627 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3879 272562006628 Cell division septal protein [Cell envelope biogenesis, outer membrane]; Region: FtsQ; COG1589 272562006629 POTRA domain, FtsQ-type; Region: POTRA_1; pfam08478 272562006630 Cell division protein FtsQ; Region: FtsQ; pfam03799 272562006631 Cell cycle protein; Region: FTSW_RODA_SPOVE; cl00511 272562006632 Phospho-N-acetylmuramoyl-pentapeptide-transferase (mraY) is an enzyme responsible for the formation of the first lipid intermediate in the synthesis of bacterial cell wall peptidoglycan. It catalyzes the formation of...; Region: GT_MraY; cd06852 272562006633 Mg++ binding site [ion binding]; other site 272562006634 putative catalytic motif [active] 272562006635 putative substrate binding site [chemical binding]; other site 272562006636 UDP-N-acetylmuramyl pentapeptide synthase [Cell envelope biogenesis, outer membrane]; Region: MurF; COG0770 272562006637 Mur ligase family, catalytic domain; Region: Mur_ligase; pfam01225 272562006638 Mur ligase middle domain; Region: Mur_ligase_M; pfam08245 272562006639 Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875 272562006640 UDP-N-acetylmuramoylalanyl-D-glutamate--2, 6-diaminopimelate ligase; Provisional; Region: murE; PRK00139 272562006641 Mur ligase family, catalytic domain; Region: Mur_ligase; pfam01225 272562006642 Mur ligase middle domain; Region: Mur_ligase_M; pfam08245 272562006643 Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875 272562006644 stage V sporulation protein D; Region: spoVD_pbp; TIGR02214 272562006645 Penicillin-binding Protein dimerization domain; Region: PBP_dimer; pfam03717 272562006646 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; pfam00905 272562006647 PASTA domain of PBP2x-like proteins, first repeat. Penicillin-binding proteins (PBPs) are the major targets for beta-lactam antibiotics, like penicillins and cephalosporins. Beta-lactam antibiotics specifically inhibit transpeptidase activity by...; Region: PASTA_Pbp2x-like_1; cd06576 272562006648 PASTA domain of PBP2x-like proteins, second repeat. Penicillin-binding proteins (PBPs) are the major targets for beta-lactam antibiotics, like penicillins and cephalosporins. Beta-lactam antibiotics specifically inhibit transpeptidase activity by...; Region: PASTA_Pbp2x-like_2; cd06575 272562006649 Septum formation initiator; Region: DivIC; cl17659 272562006650 MraW methylase family; Region: Methyltransf_5; pfam01795 272562006651 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 272562006652 S-adenosylmethionine binding site [chemical binding]; other site 272562006653 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2001 272562006654 MraZ protein; Region: MraZ; pfam02381 272562006655 MraZ protein; Region: MraZ; pfam02381 272562006656 GTP-binding protein YchF; Reviewed; Region: PRK09601 272562006657 YchF GTPase; Region: YchF; cd01900 272562006658 G1 box; other site 272562006659 GTP/Mg2+ binding site [chemical binding]; other site 272562006660 Switch I region; other site 272562006661 G2 box; other site 272562006662 Switch II region; other site 272562006663 G3 box; other site 272562006664 G4 box; other site 272562006665 G5 box; other site 272562006666 TGS_YchF_C: This subfamily represents TGS domain-containing YchF GTP-binding protein, a universally conserved GTPase whose function is unknown. The N-terminal domain of the YchF protein belongs to the Obg-like family of GTPases, and some members of the...; Region: TGS_YchF_C; cd04867 272562006667 Predicted ATP-dependent protease [Posttranslational modification, protein turnover, chaperones]; Region: LonB; COG1067 272562006668 Lon protease (S16) C-terminal proteolytic domain; Region: Lon_C; pfam05362 272562006669 Cation transporter/ATPase, N-terminus; Region: Cation_ATPase_N; pfam00690 272562006670 Cation transport ATPase [Inorganic ion transport and metabolism]; Region: MgtA; COG0474 272562006671 E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122 272562006672 Putative hydrolase of sodium-potassium ATPase alpha subunit; Region: Hydrolase_like2; pfam13246 272562006673 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 272562006674 motif II; other site 272562006675 Cation transporting ATPase, C-terminus; Region: Cation_ATPase_C; pfam00689 272562006676 putative manganese-dependent inorganic pyrophosphatase; Provisional; Region: PRK05427 272562006677 DHH family; Region: DHH; pfam01368 272562006678 The CBS domain, named after human CBS, is a small domain originally identified in cystathionine beta-synthase and is subsequently found in a wide range of different proteins. CBS domains usually occur in tandem repeats. They associate to form a so-called...; Region: CBS_pair; cl15354 272562006679 DHHA2 domain; Region: DHHA2; pfam02833 272562006680 flagellar basal body rod protein FlgG; Reviewed; Region: flgG; PRK12817 272562006681 Flagella basal body rod protein; Region: Flg_bb_rod; pfam00460 272562006682 Flagellar basal body rod FlgEFG protein C-terminal; Region: Flg_bbr_C; pfam06429 272562006683 flagellar basal body rod protein FlgG; Reviewed; Region: flgG; PRK12818 272562006684 Flagella basal body rod protein; Region: Flg_bb_rod; pfam00460 272562006685 Flagellar basal body rod FlgEFG protein C-terminal; Region: Flg_bbr_C; pfam06429 272562006686 RNA polymerase sigma factor, FliA/WhiG family; Region: FliA_WhiG; TIGR02479 272562006687 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 272562006688 Sigma-70 region 3; Region: Sigma70_r3; pfam04539 272562006689 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 272562006690 DNA binding residues [nucleotide binding] 272562006691 c-di-GMP-binding protein [Signal transduction mechanisms]; Region: COG5581 272562006692 Flagellar protein YcgR; Region: YcgR_2; pfam12945 272562006693 PilZ domain; Region: PilZ; pfam07238 272562006694 Antiactivator of flagellar biosynthesis FleN, an ATPase [Cell motility]; Region: flhG; COG0455 272562006695 FleN is a member of the Fer4_NifH superfamily. It shares the common function as an ATPase, with the ATP-binding domain at the N-terminus. In Pseudomonas aeruginosa, FleN gene is involved in regulating the number of flagella and chemotactic motility by...; Region: FleN-like; cd02038 272562006696 The Fer4_NifH superfamily contains a variety of proteins which share a common ATP-binding domain. Functionally, proteins in this superfamily use the energy from hydrolysis of NTP to transfer electron or ion; Region: Fer4_NifH; cl17203 272562006697 P-loop; other site 272562006698 flagellar biosynthesis regulator FlhF; Validated; Region: flhF; PRK05703 272562006699 SRP54-type protein, GTPase domain; Region: SRP54; smart00962 272562006700 flagellar biosynthesis protein FlhA; Validated; Region: flhA; PRK06012 272562006701 bifunctional flagellar biosynthesis protein FliR/FlhB; Provisional; Region: PRK12772 272562006702 Flagellar biosynthesis pathway, component FliR [Cell motility and secretion / Intracellular trafficking and secretion]; Region: FliR; COG1684 272562006703 flagellar biosynthetic protein FlhB; Region: flhB; TIGR00328 272562006704 Flagellar biosynthesis pathway, component FliQ [Cell motility and secretion / Intracellular trafficking and secretion]; Region: FliQ; COG1987 272562006705 flagellar biosynthesis protein FliP; Reviewed; Region: fliP; PRK05699 272562006706 flagellar biosynthetic protein FliO; Region: FliO_TIGR; TIGR03500 272562006707 Flagellar basal body-associated protein [Cell motility and secretion]; Region: FliL; COG1580 272562006708 Uncharacterized protein, possibly involved in motility [Cell motility and secretion]; Region: FlgEa; COG1582 272562006709 Flagellar hook protein FlgE [Cell motility and secretion]; Region: FlgE; COG1749 272562006710 flagellar basal body rod protein FlgB; Provisional; Region: flgB; cl19173 272562006711 Flagellar basal body rod FlgEFG protein C-terminal; Region: Flg_bbr_C; pfam06429 272562006712 Protein of unknown function (DUF3766); Region: DUF3766; cl11797 272562006713 Flagellar hook capping protein [Cell motility and secretion]; Region: FlgD; COG1843 272562006714 Flagellar hook capping protein - N-terminal region; Region: FlgD; pfam03963 272562006715 Flagellar hook-length control protein [Cell motility and secretion]; Region: FliK; COG3144 272562006716 Flagellar hook-length control protein FliK; Region: Flg_hook; pfam02120 272562006717 Flagellar biosynthesis chaperone [Cell motility and secretion / Intracellular trafficking and secretion / Posttranslational modification, protein turnover, chaperones]; Region: FliJ; COG2882 272562006718 flagellar protein export ATPase FliI; Region: FliI_clade2; TIGR03497 272562006719 ATP synthase alpha/beta family, beta-barrel domain; Region: ATP-synt_ab_N; pfam02874 272562006720 Flagellum-specific ATPase/type III secretory pathway virulence-related protein. This group of ATPases are responsible for the export of flagellum and virulence-related proteins. The bacterial flagellar motor is similar to the F0F1-ATPase, in that they...; Region: ATPase_flagellum-secretory_path_III; cd01136 272562006721 Walker A motif/ATP binding site; other site 272562006722 Walker B motif; other site 272562006723 Flagellar biosynthesis/type III secretory pathway protein [Cell motility and secretion / Intracellular trafficking and secretion]; Region: FliH; COG1317 272562006724 flagellar motor switch protein G; Validated; Region: fliG; PRK05686 272562006725 FliG N-terminal domain; Region: FliG_N; pfam14842 272562006726 FliG middle domain; Region: FliG_M; pfam14841 272562006727 FliG C-terminal domain; Region: FliG_C; pfam01706 272562006728 Flagellar basal body M-ring protein [Cell motility and secretion]; Region: fliF; COG1766 272562006729 Secretory protein of YscJ/FliF family; Region: YscJ_FliF; cl01907 272562006730 Flagellar M-ring protein C-terminal; Region: YscJ_FliF_C; pfam08345 272562006731 Protocadherin; Region: Protocadherin; pfam08374 272562006732 flagellar hook-basal body protein FliE; Provisional; Region: fliE; PRK12728 272562006733 flagellar basal body rod protein FlgC; Provisional; Region: flgC; PRK12630 272562006734 Flagella basal body rod protein; Region: Flg_bb_rod; pfam00460 272562006735 Flagellar basal body rod FlgEFG protein C-terminal; Region: Flg_bbr_C; pfam06429 272562006736 flagellar basal body rod protein FlgB; Provisional; Region: flgB; PRK12623 272562006737 flagellar basal body rod protein FlgB; Provisional; Region: flgB; cl19173 272562006738 Nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: WcaG; COG0451 272562006739 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 272562006740 NAD(P) binding site [chemical binding]; other site 272562006741 active site 272562006742 flagellin; Provisional; Region: PRK12804 272562006743 Bacterial flagellin N-terminal helical region; Region: Flagellin_N; pfam00669 272562006744 Bacterial flagellin C-terminal helical region; Region: Flagellin_C; pfam00700 272562006745 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2604 272562006746 UDP-galactopyranose mutase [Cell envelope biogenesis, outer membrane]; Region: Glf; COG0562 272562006747 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450 272562006748 UDP-galactopyranose mutase; Region: GLF; pfam03275 272562006749 Predicted glycosyltransferases [General function prediction only]; Region: COG1216 272562006750 Subfamily of Glycosyltransferase Family GT2 of unknown function; Region: GT_2_like_c; cd04186 272562006751 Probable Catalytic site; other site 272562006752 metal-binding site 272562006753 Predicted glycosyltransferases [General function prediction only]; Region: COG1216 272562006754 Subfamily of Glycosyltransferase Family GT2 of unknown function; Region: GT_2_like_c; cd04186 272562006755 Probable Catalytic site; other site 272562006756 metal-binding site 272562006757 Glycosyltransferase like family 2; Region: Glyco_tranf_2_3; pfam13641 272562006758 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394 272562006759 active site 272562006760 Glycosyltransferases, probably involved in cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: COG1215 272562006761 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394 272562006762 active site 272562006763 Glycosyltransferases involved in cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WcaA; COG0463 272562006764 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394 272562006765 active site 272562006766 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cd00761 272562006767 active site 272562006768 Glycosyl transferases group 1; Region: Glyco_trans_1_4; pfam13692 272562006769 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4641 272562006770 Glycosyl transferases group 1; Region: Glyco_trans_1_2; pfam13524 272562006771 Predicted pyridoxal phosphate-dependent enzyme apparently involved in regulation of cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WecE; COG0399 272562006772 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 272562006773 catalytic residue [active] 272562006774 GDP-fucose synthetase, extended (e) SDRs; Region: GDP_FS_SDR_e; cd05239 272562006775 GDP-4-keto-6-deoxymannose-3, 5-epimerase-4-reductase; Region: PLN02725 272562006776 NADP binding site [chemical binding]; other site 272562006777 active site 272562006778 putative substrate binding site [chemical binding]; other site 272562006779 GDP-D-mannose dehydratase [Cell envelope biogenesis, outer membrane]; Region: Gmd; COG1089 272562006780 GDP-mannose 4,6 dehydratase, extended (e) SDRs; Region: GDP_MD_SDR_e; cd05260 272562006781 NADP-binding site; other site 272562006782 homotetramer interface [polypeptide binding]; other site 272562006783 substrate binding site [chemical binding]; other site 272562006784 homodimer interface [polypeptide binding]; other site 272562006785 active site 272562006786 Putative motility protein; Region: YjfB_motility; pfam14070 272562006787 Exopolysaccharide biosynthesis protein [Cell envelope biogenesis, outer membrane]; Region: COG3955 272562006788 Exopolysaccharide biosynthesis protein [Cell envelope biogenesis, outer membrane]; Region: COG3955 272562006789 Spore coat polysaccharide biosynthesis protein, predicted glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: spsG; COG3980 272562006790 Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013 272562006791 pseudaminic acid synthase; Region: PseI; TIGR03586 272562006792 NeuB family; Region: NeuB; pfam03102 272562006793 C-terminal SAF domain of sialic acid synthetase; Region: SAF_NeuB_like; cd11615 272562006794 NeuB binding interface [polypeptide binding]; other site 272562006795 putative substrate binding site [chemical binding]; other site 272562006796 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 272562006797 Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013 272562006798 carbamoyl phosphate synthase-like protein; Provisional; Region: PRK12767 272562006799 ATP-grasp domain; Region: ATP-grasp_3; pfam02655 272562006800 SpsF is a glycosyltrnasferase implicated in the synthesis of the spore coat; Region: GT2_SpsF; cd02518 272562006801 ligand binding site; other site 272562006802 HAD superfamily (subfamily IA) hydrolase, TIGR02253; Region: CTE7 272562006803 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 272562006804 motif II; other site 272562006805 Methylmalonyl-CoA epimerase (MMCE); Region: MMCE; cd07249 272562006806 dimer interface [polypeptide binding]; other site 272562006807 substrate binding site [chemical binding]; other site 272562006808 metal binding site [ion binding]; metal-binding site 272562006809 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4641 272562006810 DUF based on E. rectale Gene description (DUF3880); Region: DUF3880; pfam12996 272562006811 Glycosyl transferases group 1; Region: Glyco_trans_1_2; pfam13524 272562006812 UDP-Glcnac (UDP-linked N-acetylglucosamine) inverting 4,6-dehydratase, extended (e) SDRs; Region: UDP_invert_4-6DH_SDR_e; cd05237 272562006813 Polysaccharide biosynthesis protein; Region: Polysacc_synt_2; pfam02719 272562006814 NAD(P) binding site [chemical binding]; other site 272562006815 homodimer interface [polypeptide binding]; other site 272562006816 substrate binding site [chemical binding]; other site 272562006817 active site 272562006818 M28 Zn-Peptidases; Region: M28_like_3; cd05644 272562006819 Domain of unknown function (DUF2172); Region: DUF2172; pfam09940 272562006820 active site 272562006821 metal binding site [ion binding]; metal-binding site 272562006822 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2604 272562006823 Aminoglycoside N3'-acetyltransferase [Defense mechanisms]; Region: COG2746 272562006824 Acyl carrier protein [Lipid metabolism / Secondary metabolites biosynthesis, transport, and catabolism]; Region: AcpP; COG0236 272562006825 Predicted enzyme involved in methoxymalonyl-ACP biosynthesis [Secondary metabolites biosynthesis, transport, and catabolism]; Region: FkbH; COG3882 272562006826 Acid Phosphatase; Region: Acid_PPase; cl17256 272562006827 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2604 272562006828 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2604 272562006829 flagellin; Provisional; Region: PRK12804 272562006830 Bacterial flagellin N-terminal helical region; Region: Flagellin_N; pfam00669 272562006831 Bacterial flagellin C-terminal helical region; Region: Flagellin_C; pfam00700 272562006832 Flagellar capping protein [Cell motility and secretion]; Region: FliD; COG1345 272562006833 Flagellar hook-associated protein 2 N-terminus; Region: FliD_N; pfam02465 272562006834 Flagellar hook-associated protein 2 C-terminus; Region: FliD_C; pfam07195 272562006835 Flagellin-specific chaperone FliS [Cell motility and secretion / Intracellular trafficking and secretion / Posttranslational modification, protein turnover, chaperones]; Region: FliS; COG1516 272562006836 Uncharacterized flagellar protein FlaG [Cell motility and secretion]; Region: FlaG; COG1334 272562006837 RNA-binding global regulator CsrA [Signal transduction mechanisms]; Region: CsrA; COG1551 272562006838 flagellar assembly protein FliW; Provisional; Region: PRK13285 272562006839 flagellar hook-associated protein FlgL; Validated; Region: flgL; PRK07701 272562006840 Bacterial flagellin N-terminal helical region; Region: Flagellin_N; pfam00669 272562006841 Bacterial flagellin C-terminal helical region; Region: Flagellin_C; pfam00700 272562006842 Flagellar hook-associated protein [Cell motility and secretion]; Region: FlgK; COG1256 272562006843 Flagella basal body rod protein; Region: Flg_bb_rod; pfam00460 272562006844 Flagellar basal body rod FlgEFG protein C-terminal; Region: Flg_bbr_C; pfam06429 272562006845 FlgN protein; Region: FlgN; pfam05130 272562006846 Negative regulator of flagellin synthesis (anti-sigma28 factor) [Transcription / Cell motility and secretion / Intracellular trafficking and secretion]; Region: FlgM; COG2747 272562006847 flagellar motor switch protein; Validated; Region: PRK08119 272562006848 CheC-like family; Region: CheC; pfam04509 272562006849 CheC-like family; Region: CheC; pfam04509 272562006850 flagellar motor switch protein FliN; Region: fliN; TIGR02480 272562006851 Flagellar motor switch protein [Cell motility and secretion]; Region: FliM; COG1868 272562006852 Surface presentation of antigens (SPOA); Region: SpoA; pfam01052 272562006853 Chemotaxis signal transduction protein [Cell motility and secretion / Signal transduction mechanisms]; Region: CheW; COG0835 272562006854 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 272562006855 active site 272562006856 phosphorylation site [posttranslational modification] 272562006857 intermolecular recognition site; other site 272562006858 dimerization interface [polypeptide binding]; other site 272562006859 Chemotaxis protein CheC, inhibitor of MCP methylation [Cell motility and secretion / Signal transduction mechanisms]; Region: CheC; COG1776 272562006860 CheC-like family; Region: CheC; pfam04509 272562006861 CheC-like family; Region: CheC; pfam04509 272562006862 Chemotaxis protein histidine kinase and related kinases [Cell motility and secretion / Signal transduction mechanisms]; Region: CheA; COG0643 272562006863 Histidine Phosphotransfer domain, involved in signalling through a two part component systems in which an autophosphorylating histidine protein kinase serves as a phosphoryl donor to a response regulator protein; the response regulator protein is...; Region: HPT; cd00088 272562006864 putative binding surface; other site 272562006865 active site 272562006866 P2 response regulator binding domain; Region: P2; pfam07194 272562006867 FinO bacterial conjugation repressor domain; the basic protein FinO is part of the the two component FinOP system which is responsible for repressing bacterial conjugation; the FinOP system represses the transfer (tra) operon of the F-plasmid which...; Region: FinO_conjug_rep; cl15270 272562006868 Signal transducing histidine kinase, homodimeric domain; Region: H-kinase_dim; pfam02895 272562006869 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 272562006870 ATP binding site [chemical binding]; other site 272562006871 Mg2+ binding site [ion binding]; other site 272562006872 G-X-G motif; other site 272562006873 CheA regulatory domain; CheA is a histidine protein kinase present in bacteria and archea. Activated by the chemotaxis receptor a histidine phosphoryl group from CheA is passed directly to an aspartate in the response regulator CheY. This signalling...; Region: CheA_reg; cd00731 272562006874 Methylase of chemotaxis methyl-accepting proteins [Cell motility and secretion / Signal transduction mechanisms]; Region: CheR; COG1352 272562006875 CheR methyltransferase, all-alpha domain; Region: CheR_N; pfam03705 272562006876 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 272562006877 S-adenosylmethionine binding site [chemical binding]; other site 272562006878 Chemotaxis response regulator containing a CheY-like receiver domain and a methylesterase domain [Cell motility and secretion / Signal transduction mechanisms]; Region: CheB; COG2201 272562006879 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 272562006880 active site 272562006881 phosphorylation site [posttranslational modification] 272562006882 intermolecular recognition site; other site 272562006883 dimerization interface [polypeptide binding]; other site 272562006884 CheB methylesterase; Region: CheB_methylest; pfam01339 272562006885 chemoreceptor glutamine deamidase CheD; Provisional; Region: PRK13490 272562006886 Chemotaxis signal transduction protein [Cell motility and secretion / Signal transduction mechanisms]; Region: CheW; COG0835 272562006887 Jag N-terminus; Region: Jag_N; pfam14804 272562006888 Uncharacterized conserved protein [Function unknown]; Region: COG1315 272562006889 PyridoxaL 5'-Phosphate Dependent Enzymes class IV (PLPDE_IV). This D-amino acid superfamily, one of five classes of PLPDE, consists of branched-chain amino acid aminotransferases (BCAT), D-amino acid transferases (DAAT), and...; Region: PLPDE_IV; cd00449 272562006890 homodimer interface [polypeptide binding]; other site 272562006891 substrate-cofactor binding pocket; other site 272562006892 pyridoxal 5'-phosphate binding site [chemical binding]; other site 272562006893 catalytic residue [active] 272562006894 haloacid dehalogenase-like hydrolase; Region: Hydrolase; pfam00702 272562006895 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 272562006896 motif II; other site 272562006897 Protein of unknown function (DUF1292); Region: DUF1292; pfam06949 272562006898 pyruvate:ferredoxin (flavodoxin) oxidoreductase, homodimeric; Region: pyruv_ox_red; TIGR02176 272562006899 Pyrimidine (PYR) binding domain of pyruvate ferredoxin oxidoreductase (PFOR), indolepyruvate ferredoxin oxidoreductase alpha subunit (IOR-alpha), and related proteins; Region: TPP_PYR_PFOR_IOR-alpha_like; cd07034 272562006900 dimer interface [polypeptide binding]; other site 272562006901 PYR/PP interface [polypeptide binding]; other site 272562006902 TPP binding site [chemical binding]; other site 272562006903 substrate binding site [chemical binding]; other site 272562006904 Pyruvate:ferredoxin oxidoreductase and related 2-oxoacid:ferredoxin oxidoreductases, gamma subunit [Energy production and conversion]; Region: PorG; COG1014 272562006905 Domain of unknown function; Region: EKR; pfam10371 272562006906 4Fe-4S dicluster domain; Region: Fer4_8; pfam13183 272562006907 4Fe-4S double cluster binding domain; Region: Fer4_16; pfam13484 272562006908 Thiamine pyrophosphate (TPP family), PFOR_PNO subfamily, TPP-binding module; composed of proteins similar to the single subunit pyruvate ferredoxin oxidoreductase (PFOR) of Desulfovibrio Africanus, present in bacteria and amitochondriate eukaryotes. This...; Region: TPP_PFOR_PNO; cd03377 272562006909 TPP-binding site [chemical binding]; other site 272562006910 dimer interface [polypeptide binding]; other site 272562006911 Uncharacterized protein with SCP/PR1 domains [Function unknown]; Region: COG2340 272562006912 SCP_bacterial: SCP-like extracellular protein domain, as found in bacteria and archaea. The wider family of SCP containing proteins includes plant pathogenesis-related protein 1 (PR-1), CRISPs, mammalian cysteine-rich secretory proteins, and allergen 5...; Region: SCP_bacterial; cd05379 272562006913 undecaprenyldiphospho-muramoylpentapeptide beta-N-acetylglucosaminyltransferase; Reviewed; Region: PRK12446 272562006914 MurG is an N-acetylglucosaminyltransferase, the last enzyme involved in the intracellular phase of peptidoglycan biosynthesis. It transfers N-acetyl-D-glucosamine (GlcNAc) from UDP-GlcNAc to the C4 hydroxyl of a lipid-linked N-acetylmuramoyl pentapeptide...; Region: GT1_MurG; cd03785 272562006915 active site 272562006916 homodimer interface [polypeptide binding]; other site 272562006917 single-stranded-DNA-specific exonuclease RecJ; Region: recJ; TIGR00644 272562006918 DHH family; Region: DHH; pfam01368 272562006919 DHHA1 domain; Region: DHHA1; pfam02272 272562006920 Predicted tRNA(5-methylaminomethyl-2-thiouridylate) methyltransferase, contains the PP-loop ATPase domain [Translation, ribosomal structure and biogenesis]; Region: TrmU; COG0482 272562006921 tRNA methyl transferase. This family represents tRNA(5-methylaminomethyl-2-thiouridine)-methyltransferase which is involved in the biosynthesis of the modified nucleoside 5-methylaminomethyl-2-thiouridine present in the wobble position of some tRNAs; Region: tRNA_Me_trans; cd01998 272562006922 Ligand Binding Site [chemical binding]; other site 272562006923 Cysteine sulfinate desulfinase/cysteine desulfurase and related enzymes [Amino acid transport and metabolism]; Region: NifS; COG1104 272562006924 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 272562006925 catalytic residue [active] 272562006926 cysteine synthase; Region: PLN02565 272562006927 CBS_like: This subgroup includes Cystathionine beta-synthase (CBS) and Cysteine synthase. CBS is a unique heme-containing enzyme that catalyzes a pyridoxal 5'-phosphate (PLP)-dependent condensation of serine and homocysteine to give cystathionine; Region: CBS_like; cd01561 272562006928 dimer interface [polypeptide binding]; other site 272562006929 pyridoxal 5'-phosphate binding site [chemical binding]; other site 272562006930 catalytic residue [active] 272562006931 Predicted transcriptional regulator [Transcription]; Region: COG1959 272562006932 Rrf2 family protein; Region: rrf2_super; TIGR00738 272562006933 glucose-1-phosphate adenylyltransferase; Provisional; Region: glgC; PRK05293 272562006934 ADP-glucose pyrophosphorylase is involved in the biosynthesis of glycogen or starch; Region: ADP_Glucose_PP; cd02508 272562006935 ligand binding site; other site 272562006936 oligomer interface; other site 272562006937 Glucose-1-phosphate adenylyltransferase, C-terminal Left-handed parallel beta helix (LbH) domain: Glucose-1-phosphate adenylyltransferase is also known as ADP-glucose synthase or ADP-glucose pyrophosphorylase. It catalyzes the first committed and...; Region: LbH_G1P_AT_C; cd04651 272562006938 dimer interface [polypeptide binding]; other site 272562006939 N-terminal domain interface [polypeptide binding]; other site 272562006940 sulfate 1 binding site; other site 272562006941 ADP-glucose pyrophosphorylase [Carbohydrate transport and metabolism]; Region: GlgC; COG0448 272562006942 ADP-glucose pyrophosphorylase is involved in the biosynthesis of glycogen or starch; Region: ADP_Glucose_PP; cd02508 272562006943 ligand binding site; other site 272562006944 oligomer interface; other site 272562006945 Glucose-1-phosphate adenylyltransferase, C-terminal Left-handed parallel beta helix (LbH) domain: Glucose-1-phosphate adenylyltransferase is also known as ADP-glucose synthase or ADP-glucose pyrophosphorylase. It catalyzes the first committed and...; Region: LbH_G1P_AT_C; cd04651 272562006946 dimer interface [polypeptide binding]; other site 272562006947 N-terminal domain interface [polypeptide binding]; other site 272562006948 sulfate 1 binding site; other site 272562006949 glycogen synthase; Provisional; Region: glgA; PRK00654 272562006950 This family is most closely related to the GT1 family of glycosyltransferases. Glycogen synthase catalyzes the formation and elongation of the alpha-1,4-glucose backbone using ADP-glucose, the second and key step of glycogen biosynthesis. This family...; Region: GT1_Glycogen_synthase_DULL1_like; cd03791 272562006951 ADP-binding pocket [chemical binding]; other site 272562006952 homodimer interface [polypeptide binding]; other site 272562006953 The family 20 carbohydrate-binding module (CBM20), also known as the starch-binding domain, is found in a large number of starch degrading enzymes including alpha-amylase, beta-amylase, glucoamylase, and CGTase (cyclodextrin glucanotransferase). CBM20 is...; Region: CBM20; cd05467 272562006954 starch-binding site 2 [chemical binding]; other site 272562006955 starch-binding site 1 [chemical binding]; other site 272562006956 Cation transport ATPase [Inorganic ion transport and metabolism]; Region: ZntA; COG2217 272562006957 Heavy-metal-associated domain (HMA) is a conserved domain of approximately 30 amino acid residues found in a number of proteins that transport or detoxify heavy metals, for example, the CPx-type heavy metal ATPases and copper chaperones. HMA domain...; Region: HMA; cd00371 272562006958 metal-binding site [ion binding] 272562006959 E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122 272562006960 Soluble P-type ATPase [General function prediction only]; Region: COG4087 272562006961 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 272562006962 dimerization interface [polypeptide binding]; other site 272562006963 putative DNA binding site [nucleotide binding]; other site 272562006964 putative Zn2+ binding site [ion binding]; other site 272562006965 Asparagine synthase (glutamine-hydrolyzing) [Amino acid transport and metabolism]; Region: AsnB; COG0367 272562006966 Glutamine amidotransferases class-II (GATase) asparagine synthase_B type. Asparagine synthetase B catalyses the ATP-dependent conversion of aspartate to asparagine. This enzyme is a homodimer, with each monomer composed of a glutaminase domain and a...; Region: AsnB; cd00712 272562006967 active site 272562006968 dimer interface [polypeptide binding]; other site 272562006969 The C-terminal domain of Asparagine Synthase B. This domain is always found associated n-terminal amidotransferase domain. Family members that contain this domain catalyse the conversion of aspartate to asparagine. Asparagine synthetase B catalyzes the...; Region: Asn_Synthase_B_C; cd01991 272562006970 Ligand Binding Site [chemical binding]; other site 272562006971 Molecular Tunnel; other site 272562006972 Predicted hydrolases of the HAD superfamily [General function prediction only]; Region: Cof; COG0561 272562006973 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 272562006974 active site 272562006975 motif I; other site 272562006976 motif II; other site 272562006977 haloacid dehalogenase-like hydrolase; Region: HAD; cl19137 272562006978 Predicted redox protein, regulator of disulfide bond formation [Posttranslational modification, protein turnover, chaperones]; Region: COG1765 272562006979 Novel bacterial esterase that cleaves esters on halogenated cyclic compounds; Region: Esterase_713_like; cl17303 272562006980 Lysophospholipase [Lipid metabolism]; Region: PldB; COG2267 272562006981 Putative lysophospholipase; Region: Hydrolase_4; pfam12146 272562006982 catalytic site [active] 272562006983 TAP-like protein; Region: Abhydrolase_4; pfam08386 272562006984 Site-specific recombinases, DNA invertase Pin homologs [DNA replication, recombination, and repair]; Region: PinR; COG1961 272562006985 Serine Recombinase (SR) family, TndX-like transposase subfamily, catalytic domain; composed of large serine recombinases similar to Clostridium TndX and TnpX transposases. Serine recombinases catalyze site-specific recombination of DNA molecules by a...; Region: SR_TndX_transposase; cd03770 272562006986 putative catalytic residues [active] 272562006987 catalytic nucleophile [active] 272562006988 Recombinase; Region: Recombinase; pfam07508 272562006989 Recombinase zinc beta ribbon domain; Region: Zn_ribbon_recom; pfam13408 272562006990 Asparagine synthase (glutamine-hydrolyzing) [Amino acid transport and metabolism]; Region: AsnB; COG0367 272562006991 The C-terminal domain of Asparagine Synthase B. This domain is always found associated n-terminal amidotransferase domain. Family members that contain this domain catalyse the conversion of aspartate to asparagine. Asparagine synthetase B catalyzes the...; Region: Asn_Synthase_B_C; cd01991 272562006992 Prokaryotic UGPase catalyses the synthesis of UDP-glucose; Region: UGPase_prokaryotic; cd02541 272562006993 dTDP-glucose pyrophosphorylase [Cell envelope biogenesis, outer membrane]; Region: RfbA; COG1209 272562006994 active site 272562006995 tetramer interface; other site 272562006996 4-amino-4-deoxy-L-arabinose transferase and related glycosyltransferases of PMT family [Cell envelope biogenesis, outer membrane]; Region: ArnT; COG1807 272562006997 Dolichyl-phosphate-mannose-protein mannosyltransferase; Region: PMT_2; pfam13231 272562006998 Alpha-glucosidases, family 31 of glycosyl hydrolases [Carbohydrate transport and metabolism]; Region: COG1501 272562006999 The enzymes of glycosyl hydrolase family 31 (GH31) occur in prokaryotes, eukaryotes, and archaea with a wide range of hydrolytic activities, including alpha-glucosidase (glucoamylase and sucrase-isomaltase), alpha-xylosidase, 6-alpha-glucosyltransferase; Region: GH31; cl11402 272562007000 active site 272562007001 catalytic site [active] 272562007002 Chitobiase/beta-hexosaminidase C-terminal domain; Region: CHB_HEX_C; pfam03174 272562007003 Fn3 associated; Region: Fn3_assoc; pfam13287 272562007004 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: COG4585 272562007005 Histidine kinase; Region: HisKA_3; pfam07730 272562007006 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 272562007007 ATP binding site [chemical binding]; other site 272562007008 Mg2+ binding site [ion binding]; other site 272562007009 G-X-G motif; other site 272562007010 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 272562007011 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 272562007012 active site 272562007013 phosphorylation site [posttranslational modification] 272562007014 intermolecular recognition site; other site 272562007015 dimerization interface [polypeptide binding]; other site 272562007016 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 272562007017 DNA binding residues [nucleotide binding] 272562007018 dimerization interface [polypeptide binding]; other site 272562007019 MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704 272562007020 ABC-type transport system, involved in lipoprotein release, permease component [Cell envelope biogenesis, outer membrane]; Region: LolE; COG4591 272562007021 FtsX-like permease family; Region: FtsX; pfam02687 272562007022 MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704 272562007023 ABC-type transport system, involved in lipoprotein release, permease component [Cell envelope biogenesis, outer membrane]; Region: LolE; COG4591 272562007024 FtsX-like permease family; Region: FtsX; pfam02687 272562007025 ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136 272562007026 ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255 272562007027 Walker A/P-loop; other site 272562007028 ATP binding site [chemical binding]; other site 272562007029 Q-loop/lid; other site 272562007030 ABC transporter signature motif; other site 272562007031 Walker B; other site 272562007032 D-loop; other site 272562007033 H-loop/switch region; other site 272562007034 phenylalanyl-tRNA synthetase alpha chain; Provisional; Region: PTZ00326 272562007035 3-amino-5-hydroxybenzoic acid synthase family (AHBA_syn). AHBA_syn family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The members of this CD are involved in various biosynthetic pathways for secondary...; Region: AHBA_syn; cd00616 272562007036 inhibitor-cofactor binding pocket; inhibition site 272562007037 pyridoxal 5'-phosphate binding site [chemical binding]; other site 272562007038 catalytic residue [active] 272562007039 Predicted HD-superfamily hydrolase [General function prediction only]; Region: COG3481 272562007040 YhaM_OBF_like: A subfamily of OB folds similar to that found in Bacillus subtilis YhaM and Staphylococcus aureus cmp-binding factor-1 (SaCBF1). Both these proteins are 3'-to-5'exoribonucleases. YhaM requires Mn2+ or Co2+ for activity and is...; Region: YhaM_OBF_like; cd04492 272562007041 generic binding surface II; other site 272562007042 generic binding surface I; other site 272562007043 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 272562007044 Zn2+ binding site [ion binding]; other site 272562007045 Mg2+ binding site [ion binding]; other site 272562007046 helicase-exonuclease AddAB, AddA subunit, Firmicutes type; Region: addA_Gpos; TIGR02785 272562007047 Part of AAA domain; Region: AAA_19; pfam13245 272562007048 UvrD-like helicase C-terminal domain; Region: UvrD_C_2; pfam13538 272562007049 ATP-dependent nuclease, subunit B [DNA replication, recombination, and repair]; Region: AddB; COG3857 272562007050 Exodeoxyribonuclease V, gamma subunit; Region: Exonuc_V_gamma; cl19914 272562007051 PD-(D/E)XK nuclease superfamily; Region: PDDEXK_1; pfam12705 272562007052 Serine-glycine hydroxymethyltransferase (SHMT). This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). SHMT carries out interconversion of serine and glycine; it catalyzes the transfer of hydroxymethyl...; Region: SHMT; cd00378 272562007053 dimer interface [polypeptide binding]; other site 272562007054 Beta-eliminating lyase; Region: Beta_elim_lyase; pfam01212 272562007055 active site 272562007056 glycine-pyridoxal phosphate binding site [chemical binding]; other site 272562007057 folate binding site [chemical binding]; other site 272562007058 Uncharacterized conserved protein [Function unknown]; Region: COG2966 272562007059 Protein of unknown function (DUF1212); Region: DUF1212; pfam06738 272562007060 Uncharacterized conserved protein [Function unknown]; Region: COG3610 272562007061 Transcriptional regulators CsoR (copper-sensitive operon repressor), RcnR, and FrmR, and related domains; this domain superfamily was previously known as DUF156; Region: CsoR-like_DUF156; cd10148 272562007062 putative homodimer interface [polypeptide binding]; other site 272562007063 putative homotetramer interface [polypeptide binding]; other site 272562007064 putative allosteric switch controlling residues; other site 272562007065 putative metal binding site [ion binding]; other site 272562007066 putative homodimer-homodimer interface [polypeptide binding]; other site 272562007067 aspartyl-tRNA synthetase; Validated; Region: aspS; PRK00476 272562007068 EcAspRS_like_N: N-terminal, anticodon recognition domain of the type found in Escherichia coli aspartyl-tRNA synthetase (AspRS), the human mitochondrial (mt) AspRS-2, the discriminating (D) Thermus thermophilus AspRS-1, and the nondiscriminating (ND)...; Region: EcAspRS_like_N; cd04317 272562007069 dimer interface [polypeptide binding]; other site 272562007070 anticodon binding site; other site 272562007071 Asp tRNA synthetase (aspRS) class II core domain. Class II assignment is based upon its structure and the presence of three characteristic sequence motifs. AspRS is a homodimer, which attaches a specific amino acid to the 3' OH group of ribose of...; Region: AspRS_core; cd00777 272562007072 homodimer interface [polypeptide binding]; other site 272562007073 motif 1; other site 272562007074 active site 272562007075 motif 2; other site 272562007076 GAD domain; Region: GAD; pfam02938 272562007077 motif 3; other site 272562007078 coproporphyrinogen III oxidase; Provisional; Region: PRK08207 272562007079 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 272562007080 FeS/SAM binding site; other site 272562007081 Zn-dependent hydrolases, including glyoxylases [General function prediction only]; Region: GloB; COG0491 272562007082 D-Tyrosyl-tRNAtyr deacylases; a class of tRNA-dependent hydrolases which are capable of hydrolyzing the ester bond of D-Tyrosyl-tRNA reducing the level of cellular D-Tyrosine while recycling the peptidyl-tRNA; found in bacteria and in eukaryotes but not...; Region: Dtyr_deacylase; cd00563 272562007083 putative active site [active] 272562007084 dimerization interface [polypeptide binding]; other site 272562007085 putative tRNAtyr binding site [nucleotide binding]; other site 272562007086 Guanosine polyphosphate pyrophosphohydrolases/synthetases [Signal transduction mechanisms / Transcription]; Region: SpoT; COG0317 272562007087 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 272562007088 Zn2+ binding site [ion binding]; other site 272562007089 Mg2+ binding site [ion binding]; other site 272562007090 Nucleotidyltransferase (NT) domain of RelA- and SpoT-like ppGpp synthetases and hydrolases; Region: NT_Rel-Spo_like; cd05399 272562007091 synthetase active site [active] 272562007092 NTP binding site [chemical binding]; other site 272562007093 metal binding site [ion binding]; metal-binding site 272562007094 TGS_RelA_SpoT: The RelA (SpoT) protein, also referred to as ppGpp hydrolase/synthetase, is a ribosome-associated protein that is activated during amino acid starvation and thought to mediate the stringent response. RelA contains a TGS domain, named after...; Region: TGS_RelA_SpoT; cd01668 272562007095 ACT domain found C-terminal of the RelA/SpoT domains; Region: ACT_RelA-SpoT; cd04876 272562007096 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 272562007097 active site 272562007098 Single-stranded DNA-specific exonuclease [DNA replication, recombination, and repair]; Region: RecJ; COG0608 272562007099 DHH family; Region: DHH; pfam01368 272562007100 preprotein translocase subunit SecF; Reviewed; Region: secF; PRK13022 272562007101 Protein export membrane protein; Region: SecD_SecF; pfam02355 272562007102 preprotein translocase subunit SecD; Reviewed; Region: secD; PRK05812 272562007103 protein-export membrane protein, SecD/SecF family; Region: 2A0604s01; TIGR00916 272562007104 SCIFF radical SAM maturase; Region: rSAM_six_Cys; TIGR03974 272562007105 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 272562007106 FeS/SAM binding site; other site 272562007107 radical SAM additional 4Fe4S-binding SPASM domain; Region: rSAM_more_4Fe4S; TIGR04085 272562007108 Protein of unknown function (DUF3792); Region: DUF3792; pfam12670 272562007109 preprotein translocase subunit YajC; Validated; Region: yajC; PRK05585 272562007110 queuine tRNA-ribosyltransferase; Provisional; Region: tgt; PRK00112 272562007111 Queuine/archaeosine tRNA-ribosyltransferase [Translation, ribosomal structure and biogenesis]; Region: Tgt; COG0343 272562007112 S-adenosylmethionine:tRNA ribosyltransferase-isomerase; Provisional; Region: queA; PRK00147 272562007113 Holliday junction DNA helicase RuvB; Reviewed; Region: ruvB; PRK00080 272562007114 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 272562007115 Walker A motif; other site 272562007116 ATP binding site [chemical binding]; other site 272562007117 Walker B motif; other site 272562007118 arginine finger; other site 272562007119 Holliday junction DNA helicase ruvB C-terminus; Region: RuvB_C; pfam05491 272562007120 Holliday junction DNA helicase RuvA; Reviewed; Region: ruvA; PRK00116 272562007121 RuvA N terminal domain; Region: RuvA_N; pfam01330 272562007122 Helix-hairpin-helix domain; Region: HHH_5; pfam14520 272562007123 RuvA, C-terminal domain; Region: RuvA_C; pfam07499 272562007124 Acyl-CoA reductase LuxC; Region: ALDH_Acyl-CoA-Red_LuxC; cd07080 272562007125 putative catalytic cysteine [active] 272562007126 Acyl-protein synthetase, LuxE; Region: LuxE; pfam04443 272562007127 Biotin carboxyl carrier protein [Lipid metabolism]; Region: AccB; COG0511 272562007128 The biotinyl-domain or biotin carboxyl carrier protein (BCCP) domain is present in all biotin-dependent enzymes, such as acetyl-CoA carboxylase, pyruvate carboxylase, propionyl-CoA carboxylase, methylcrotonyl-CoA carboxylase, geranyl-CoA carboxylase; Region: biotinyl_domain; cd06850 272562007129 carboxyltransferase (CT) interaction site; other site 272562007130 biotinylation site [posttranslational modification]; other site 272562007131 Zinc metalloprotease (elastase) [Amino acid transport and metabolism]; Region: LasB; COG3227 272562007132 Fungalysin/Thermolysin Propeptide Motif; Region: FTP; pfam07504 272562007133 Peptidase propeptide and YPEB domain; Region: PepSY; pfam03413 272562007134 Peptidase M4 family includes thermolysin, protealysin, aureolysin and neutral protease; Region: M4_neutral_protease; cd09597 272562007135 active site 272562007136 Zn binding site [ion binding]; other site 272562007137 Bacterial surface proteins containing Ig-like domains [Cell motility and secretion]; Region: COG5492 272562007138 Clostridial hydrophobic, with a conserved W residue, domain; Region: ChW; smart00728 272562007139 Clostridial hydrophobic, with a conserved W residue, domain; Region: ChW; smart00728 272562007140 Clostridial hydrophobic, with a conserved W residue, domain; Region: ChW; smart00728 272562007141 Clostridial hydrophobic, with a conserved W residue, domain; Region: ChW; smart00728 272562007142 Clostridial hydrophobic, with a conserved W residue, domain; Region: ChW; smart00728 272562007143 Clostridial hydrophobic, with a conserved W residue, domain; Region: ChW; smart00728 272562007144 hypothetical protein; Validated; Region: PRK00110 272562007145 Uncharacterized conserved protein [Function unknown]; Region: COG1739 272562007146 Uncharacterized protein family UPF0029; Region: UPF0029; pfam01205 272562007147 Domain of unknown function (DUF1949); Region: DUF1949; pfam09186 272562007148 Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain (MocR family) and their eukaryotic orthologs [Transcription / Amino acid transport and metabolism]; Region: ARO8; COG1167 272562007149 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 272562007150 DNA-binding site [nucleotide binding]; DNA binding site 272562007151 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 272562007152 pyridoxal 5'-phosphate binding site [chemical binding]; other site 272562007153 homodimer interface [polypeptide binding]; other site 272562007154 catalytic residue [active] 272562007155 Nucleotidyltransferase (NT) domain of Staphylococcus aureus kanamycin nucleotidyltransferase, and similar proteins; Region: NT_KNTase_like; cd05403 272562007156 active site 272562007157 NTP binding site [chemical binding]; other site 272562007158 metal binding triad [ion binding]; metal-binding site 272562007159 antibiotic binding site [chemical binding]; other site 272562007160 GTP-binding protein HflX; Region: GTP_HflX; TIGR03156 272562007161 GTP-binding GTPase N-terminal; Region: GTP-bdg_N; pfam13167 272562007162 HflX GTPase family; Region: HflX; cd01878 272562007163 G1 box; other site 272562007164 GTP/Mg2+ binding site [chemical binding]; other site 272562007165 Switch I region; other site 272562007166 G2 box; other site 272562007167 G3 box; other site 272562007168 Switch II region; other site 272562007169 G4 box; other site 272562007170 G5 box; other site 272562007171 sporulation protein YunB; Region: spo_yunB; TIGR02832 272562007172 Transglycosylase; Region: Transgly; pfam00912 272562007173 penicillin-binding protein, 1A family; Region: PBP_1a_fam; TIGR02074 272562007174 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; cl17760 272562007175 stage V sporulation protein AD; Validated; Region: PRK08304 272562007176 stage V sporulation protein AD; Region: spore_V_AD; TIGR02845 272562007177 stage V sporulation protein AC; Region: spore_V_AC; TIGR02838 272562007178 sporulation sigma factor SigF; Validated; Region: PRK05572 272562007179 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 272562007180 Sigma-70 region 3; Region: Sigma70_r3; pfam04539 272562007181 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 272562007182 DNA binding residues [nucleotide binding] 272562007183 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 272562007184 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 272562007185 ATP binding site [chemical binding]; other site 272562007186 Mg2+ binding site [ion binding]; other site 272562007187 G-X-G motif; other site 272562007188 Sulphate Transporter and Anti-Sigma factor antagonist) domain of anti-anti-sigma factors, key regulators of anti-sigma factors by phosphorylation; Region: STAS_anti-anti-sigma_factors; cd07043 272562007189 anti sigma factor interaction site; other site 272562007190 regulatory phosphorylation site [posttranslational modification]; other site 272562007191 Type II restriction enzyme, methylase subunits [Defense mechanisms]; Region: COG1002 272562007192 Methyltransferase domain; Region: Methyltransf_26; pfam13659 272562007193 TaqI-like C-terminal specificity domain; Region: TaqI_C; pfam12950 272562007194 Methenyl tetrahydrofolate cyclohydrolase [Amino acid transport and metabolism]; Region: COG3404 272562007195 Nitroreductase-like family 3. A subfamily of the nitroreductase family containing uncharacterized proteins that are similar to nitroreductase. Nitroreductase catalyzes the reduction of nitroaromatic compounds such as nitrotoluenes, nitrofurans and...; Region: Nitroreductase_3; cd02139 272562007196 putative FMN binding site [chemical binding]; other site 272562007197 Predicted glycosyltransferases [General function prediction only]; Region: COG1216 272562007198 Subfamily of Glycosyltransferase Family GT2 of unknown function; Region: GT_2_like_c; cd04186 272562007199 Probable Catalytic site; other site 272562007200 metal-binding site 272562007201 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 272562007202 Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013 272562007203 Membrane protein involved in the export of O-antigen and teichoic acid [General function prediction only]; Region: RfbX; COG2244 272562007204 Wzx, a subfamily of the multidrug and toxic compound extrusion (MATE)-like proteins; Region: MATE_Wzx_like; cd13128 272562007205 dTDP-6-deoxy-L-lyxo-4-hexulose reductase and related proteins, extended (e) SDRs; Region: dTDP_HR_like_SDR_e; cd05254 272562007206 RmlD substrate binding domain; Region: RmlD_sub_bind; pfam04321 272562007207 NADP binding site [chemical binding]; other site 272562007208 active site 272562007209 putative substrate binding site [chemical binding]; other site 272562007210 Predicted xylanase/chitin deacetylase [Carbohydrate transport and metabolism]; Region: CDA1; COG0726 272562007211 Putative catalytic NodB homology domain of PgaB, IcaB, and similar proteins which consist of a deformed (beta/alpha)8 barrel fold with 5- or 6-strands; Region: CE4_NodB_like_5s_6s; cd10918 272562007212 putative active site [active] 272562007213 putative metal binding site [ion binding]; other site 272562007214 The glycosyltransferase WecG/TagA superfamily contains Escherichia coli WecG, Bacillus subtilis TagA and related proteins. E. coli WecG is believed to be a UDP-N-acetyl-D-mannosaminuronic acid transferase, and is involved in enterobacterial common...; Region: Glyco_transf_WecG_TagA; cd06533 272562007215 Lipid A core - O-antigen ligase and related enzymes [Cell envelope biogenesis, outer membrane]; Region: RfaL; COG3307 272562007216 O-Antigen ligase; Region: Wzy_C; pfam04932 272562007217 Predicted glycosyltransferases [General function prediction only]; Region: COG1216 272562007218 Subfamily of Glycosyltransferase Family GT2 of unknown function; Region: GT_2_like_c; cd04186 272562007219 Probable Catalytic site; other site 272562007220 metal-binding site 272562007221 glycosyltransferase, TIGR04182 family; Region: glyco_TIGR04182 272562007222 DPM_DPG-synthase_like is a member of the Glycosyltransferase 2 superfamily; Region: DPM_DPG-synthase_like; cd04179 272562007223 Ligand binding site; other site 272562007224 Putative Catalytic site; other site 272562007225 DXD motif; other site 272562007226 Bacterial surface proteins containing Ig-like domains [Cell motility and secretion]; Region: COG5492 272562007227 Clostridial hydrophobic, with a conserved W residue, domain; Region: ChW; smart00728 272562007228 Clostridial hydrophobic, with a conserved W residue, domain; Region: ChW; smart00728 272562007229 Clostridial hydrophobic, with a conserved W residue, domain; Region: ChW; smart00728 272562007230 Clostridial hydrophobic, with a conserved W residue, domain; Region: ChW; smart00728 272562007231 Clostridial hydrophobic, with a conserved W residue, domain; Region: ChW; smart00728 272562007232 Clostridial hydrophobic, with a conserved W residue, domain; Region: ChW; smart00728 272562007233 Bacterial Ig-like domain (group 3); Region: Big_3_4; pfam13754 272562007234 Beta- N-acetylglucosaminidase [Carbohydrate transport and metabolism]; Region: LytD; COG4193 272562007235 Lysozyme subfamily 2; Region: LYZ2; smart00047 272562007236 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 272562007237 Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013 272562007238 Predicted glycosyltransferases [General function prediction only]; Region: COG1216 272562007239 Subfamily of Glycosyltransferase Family GT2 of unknown function; Region: GT_2_like_c; cd04186 272562007240 Probable Catalytic site; other site 272562007241 metal-binding site 272562007242 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 272562007243 Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013 272562007244 ABC-type polysaccharide/polyol phosphate transport system, ATPase component [Carbohydrate transport and metabolism / Cell envelope biogenesis, outer membrane]; Region: TagH; COG1134 272562007245 ATP-binding cassette component of polysaccharide transport system; Region: ABC_KpsT_Wzt; cd03220 272562007246 Walker A/P-loop; other site 272562007247 ATP binding site [chemical binding]; other site 272562007248 Q-loop/lid; other site 272562007249 ABC transporter signature motif; other site 272562007250 Walker B; other site 272562007251 D-loop; other site 272562007252 H-loop/switch region; other site 272562007253 C-Terminal domain of O-antigenic polysaccharide transporter protein Wzt and related proteins; Region: Wzt_C-like; cd10147 272562007254 putative carbohydrate binding site [chemical binding]; other site 272562007255 ABC-type polysaccharide/polyol phosphate export systems, permease component [Carbohydrate transport and metabolism / Cell envelope biogenesis, outer membrane]; Region: TagG; COG1682 272562007256 exopolysaccharide biosynthesis polyprenyl glycosylphosphotransferase; Region: EPS_sugtrans; TIGR03025 272562007257 Sugar transferases involved in lipopolysaccharide synthesis [Cell envelope biogenesis, outer membrane]; Region: WcaJ; COG2148 272562007258 dTDP-4-dehydrorhamnose 3,5-epimerase; Region: dTDP_sugar_isom; pfam00908 272562007259 dTDP-D-glucose 4,6-dehydratase [Cell envelope biogenesis, outer membrane]; Region: RfbB; COG1088 272562007260 dTDP-D-glucose 4,6-dehydratase, extended (e) SDRs; Region: dTDP_GD_SDR_e; cd05246 272562007261 NAD binding site [chemical binding]; other site 272562007262 substrate binding site [chemical binding]; other site 272562007263 homodimer interface [polypeptide binding]; other site 272562007264 active site 272562007265 G1P_TT_short is the short form of glucose-1-phosphate thymidylyltransferase; Region: G1P_TT_short; cd02538 272562007266 glucose-1-phosphate thymidylyltransferase, short form; Region: rmlA; TIGR01207 272562007267 substrate binding site; other site 272562007268 tetramer interface; other site 272562007269 Nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: WcaG; COG0451 272562007270 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 272562007271 NAD(P) binding site [chemical binding]; other site 272562007272 active site 272562007273 Prokaryotic UGPase catalyses the synthesis of UDP-glucose; Region: UGPase_prokaryotic; cd02541 272562007274 dTDP-glucose pyrophosphorylase [Cell envelope biogenesis, outer membrane]; Region: RfbA; COG1209 272562007275 active site 272562007276 tetramer interface; other site 272562007277 Tetratricopeptide repeat; Region: TPR_12; pfam13424 272562007278 Tetratricopeptide repeat; Region: TPR_12; pfam13424 272562007279 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 272562007280 binding surface 272562007281 TPR motif; other site 272562007282 phosphoglucomutase-2-like protein; Provisional; Region: PTZ00150 272562007283 This CD includes PGM2 (phosphoglucomutase 2) and PGM2L1 (phosphoglucomutase 2-like 1). The mammalian PGM2 is thought to be a phosphopentomutase that catalyzes the conversion of the nucleoside breakdown products, ribose-1-phosphate and...; Region: PGM2; cd05799 272562007284 active site 272562007285 substrate binding site [chemical binding]; other site 272562007286 metal binding site [ion binding]; metal-binding site 272562007287 Arginine/lysine/ornithine decarboxylases [Amino acid transport and metabolism]; Region: LdcC; COG1982 272562007288 Ornithine decarboxylase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD corresponds to ornithine decarboxylase (ODC), arginine decarboxylase (ADC) and lysine...; Region: Orn_deC_like; cd00615 272562007289 homodimer interface [polypeptide binding]; other site 272562007290 pyridoxal 5'-phosphate binding site [chemical binding]; other site 272562007291 catalytic residue [active] 272562007292 Orn/Lys/Arg decarboxylase, C-terminal domain; Region: OKR_DC_1_C; pfam03711 272562007293 Uncharacterized conserved protein [Function unknown]; Region: COG1683 272562007294 recombination and DNA strand exchange inhibitor protein; Reviewed; Region: PRK00409 272562007295 MutS domain III; Region: MutS_III; pfam05192 272562007296 ATP-binding cassette domain of MutS2; Region: ABC_MutS2; cd03280 272562007297 Walker A/P-loop; other site 272562007298 ATP binding site [chemical binding]; other site 272562007299 Q-loop/lid; other site 272562007300 ABC transporter signature motif; other site 272562007301 Walker B; other site 272562007302 D-loop; other site 272562007303 H-loop/switch region; other site 272562007304 Protein of unknown function (DUF2884); Region: DUF2884; cl19726 272562007305 Smr domain; Region: Smr; pfam01713 272562007306 Collagenase and related proteases [Posttranslational modification, protein turnover, chaperones]; Region: COG0826 272562007307 Collagenase; Region: DUF3656; pfam12392 272562007308 Peptidase family U32; Region: Peptidase_U32; cl03113 272562007309 Acetyltransferase (isoleucine patch superfamily) [General function prediction only]; Region: WbbJ; COG0110 272562007310 Left-handed parallel beta-Helix (LbetaH or LbH) domain: The alignment contains 5 turns, each containing three imperfect tandem repeats of a hexapeptide repeat motif (X-[STAV]-X-[LIV]-[GAED]-X). Proteins containing hexapeptide repeats are often enzymes...; Region: LbetaH; cl00160 272562007311 putative trimer interface [polypeptide binding]; other site 272562007312 putative CoA binding site [chemical binding]; other site 272562007313 Nudix hydrolase is a superfamily of enzymes found in all three kingdoms of life, and it catalyzes the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+...; Region: Nudix_Hydrolase; cl00447 272562007314 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 272562007315 Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013 272562007316 Glycosyltransferases involved in cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WcaA; COG0463 272562007317 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394 272562007318 active site 272562007319 Glycosyltransferase like family 2; Region: Glyco_tranf_2_3; pfam13641 272562007320 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cd00761 272562007321 active site 272562007322 Glycosyltransferase like family 2; Region: Glyco_tranf_2_3; pfam13641 272562007323 Subfamily of Glycosyltransferase Family GT2 of unknown function; Region: GT_2_like_c; cd04186 272562007324 Probable Catalytic site; other site 272562007325 metal-binding site 272562007326 Glycosyltransferases involved in cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WcaA; COG0463 272562007327 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394 272562007328 active site 272562007329 3-amino-5-hydroxybenzoic acid synthase family (AHBA_syn). AHBA_syn family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The members of this CD are involved in various biosynthetic pathways for secondary...; Region: AHBA_syn; cd00616 272562007330 inhibitor-cofactor binding pocket; inhibition site 272562007331 pyridoxal 5'-phosphate binding site [chemical binding]; other site 272562007332 catalytic residue [active] 272562007333 Glycosyltransferases, probably involved in cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: COG1215 272562007334 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394 272562007335 active site 272562007336 Protein of unknown function (DUF3343); Region: DUF3343; pfam11823 272562007337 Cysteine desulfurase (SufS)-like. This family belongs to the pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to cysteine desulfurase (SufS) and selenocysteine lyase. SufS...; Region: SufS_like; cd06453 272562007338 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 272562007339 catalytic residue [active] 272562007340 Cell division protein ZapA (stimulator of FtsZ polymerization and Z-ring component) [Cell cycle control, cell division, chromosome partitioning]; Region: zapA; COG3027 272562007341 phenylalanyl-tRNA synthetase subunit beta; Reviewed; Region: pheT; PRK00629 272562007342 tRNA-binding-domain-containing prokaryotic phenylalanly tRNA synthetase (PheRS) beta chain. PheRS aminoacylate phenylalanine transfer RNAs (tRNAphe). PheRSs belong structurally to class II aminoacyl tRNA synthetases (aaRSs) but, as they aminoacylate...; Region: tRNA_bind_bactPheRS; cd02796 272562007343 putative tRNA-binding site [nucleotide binding]; other site 272562007344 B3/4 domain; Region: B3_4; pfam03483 272562007345 tRNA synthetase B5 domain; Region: B5; smart00874 272562007346 Phenylalanyl-tRNA synthetase (PheRS) beta chain core domain. PheRS belongs to class II aminoacyl-tRNA synthetases (aaRS) based upon its structure. While class II aaRSs generally aminoacylate the 3'-OH ribose of the appropriate tRNA, PheRS is an...; Region: PheRS_beta_core; cd00769 272562007347 dimer interface [polypeptide binding]; other site 272562007348 motif 1; other site 272562007349 motif 3; other site 272562007350 motif 2; other site 272562007351 Ferredoxin-fold anticodon binding domain; Region: FDX-ACB; pfam03147 272562007352 phenylalanyl-tRNA synthetase subunit alpha; Validated; Region: pheS; PRK00488 272562007353 Aminoacyl tRNA synthetase class II, N-terminal domain; Region: Phe_tRNA-synt_N; pfam02912 272562007354 Phenylalanyl-tRNA synthetase (PheRS) alpha chain catalytic core domain. PheRS belongs to class II aminoacyl-tRNA synthetases (aaRS) based upon its structure and the presence of three characteristic sequence motifs. This domain is primarily responsible...; Region: PheRS_alpha_core; cd00496 272562007355 dimer interface [polypeptide binding]; other site 272562007356 motif 1; other site 272562007357 active site 272562007358 motif 2; other site 272562007359 motif 3; other site 272562007360 rRNA methylases [Translation, ribosomal structure and biogenesis]; Region: SpoU; COG0566 272562007361 RNA 2'-O ribose methyltransferase substrate binding; Region: SpoU_sub_bind; smart00967 272562007362 SpoU rRNA Methylase family; Region: SpoU_methylase; pfam00588 272562007363 Ribosomal protein L20; Region: Ribosomal_L20; cd07026 272562007364 23S rRNA binding site [nucleotide binding]; other site 272562007365 L21 binding site [polypeptide binding]; other site 272562007366 L13 binding site [polypeptide binding]; other site 272562007367 50S ribosomal protein L35; Reviewed; Region: rpmI; PRK00172 272562007368 Translation initiation factor 3 (IF-3) [Translation, ribosomal structure and biogenesis]; Region: InfC; COG0290 272562007369 Translation initiation factor IF-3, N-terminal domain; Region: IF3_N; pfam05198 272562007370 Translation initiation factor IF-3, C-terminal domain; Region: IF3_C; pfam00707 272562007371 threonyl-tRNA synthetase; Reviewed; Region: thrS; PRK00413 272562007372 TGS _ThrRS_N: ThrRS (threonyl-tRNA Synthetase) is a class II tRNA synthetase that couples threonine to its cognate tRNA. In addition to its catalytic and anticodon-binding domains, ThrRS has an N-terminal TGS domain, named after the ThrRS, GTPase, and...; Region: TGS_ThrRS_N; cd01667 272562007373 Threonyl and Alanyl tRNA synthetase second additional domain; Region: tRNA_SAD; smart00863 272562007374 Threonyl-tRNA synthetase (ThrRS) class II core catalytic domain. ThrRS is a homodimer. It is responsible for the attachment of threonine to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for ATP-dependent...; Region: ThrRS_core; cd00771 272562007375 active site 272562007376 dimer interface [polypeptide binding]; other site 272562007377 motif 1; other site 272562007378 motif 2; other site 272562007379 motif 3; other site 272562007380 ThrRS Threonyl-anticodon binding domain. ThrRS belongs to class II aminoacyl-tRNA synthetases (aaRS). This alignment contains the anticodon binding domain, which is responsible for specificity in tRNA-binding, so that the activated amino acid is...; Region: ThrRS_anticodon; cd00860 272562007381 anticodon binding site; other site 272562007382 putative sporulation protein YtxC; Region: spo_ytxC; TIGR02834 272562007383 Small, acid-soluble spore proteins, alpha/beta type; Region: SASP; pfam00269 272562007384 Bacterial surface proteins containing Ig-like domains [Cell motility and secretion]; Region: COG5492 272562007385 Clostridial hydrophobic, with a conserved W residue, domain; Region: ChW; smart00728 272562007386 Clostridial hydrophobic, with a conserved W residue, domain; Region: ChW; smart00728 272562007387 Clostridial hydrophobic, with a conserved W residue, domain; Region: ChW; smart00728 272562007388 Bacterial Ig-like domain (group 2); Region: Big_2; pfam02368 272562007389 Bacterial Ig-like domain (group 2); Region: Big_2; pfam02368 272562007390 Bacterial surface proteins containing Ig-like domains [Cell motility and secretion]; Region: COG5492 272562007391 Clostridial hydrophobic, with a conserved W residue, domain; Region: ChW; smart00728 272562007392 Clostridial hydrophobic, with a conserved W residue, domain; Region: ChW; smart00728 272562007393 Clostridial hydrophobic, with a conserved W residue, domain; Region: ChW; smart00728 272562007394 Clostridial hydrophobic, with a conserved W residue, domain; Region: ChW; smart00728 272562007395 Clostridial hydrophobic, with a conserved W residue, domain; Region: ChW; smart00728 272562007396 Clostridial hydrophobic, with a conserved W residue, domain; Region: ChW; smart00728 272562007397 Transglutaminase-like superfamily; Region: Transglut_core; cl17362 272562007398 Hsp33-like chaperonin; Reviewed; Region: hslO; PRK00114 272562007399 Heat shock protein 33 (Hsp33): Cytosolic protein that acts as a molecular chaperone under oxidative conditions. In normal (reducing) cytosolic conditions, four conserved Cys residues are coordinated by a Zn ion. Under oxidative stress (such as heat...; Region: Hsp33; cd00498 272562007400 dimerization interface [polypeptide binding]; other site 272562007401 domain crossover interface; other site 272562007402 redox-dependent activation switch; other site 272562007403 Methyltransferase domain; Region: Methyltransf_31; pfam13847 272562007404 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 272562007405 S-adenosylmethionine binding site [chemical binding]; other site 272562007406 Small, acid-soluble spore proteins, alpha/beta type; Region: SASP; pfam00269 272562007407 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppC; COG1173 272562007408 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 272562007409 dimer interface [polypeptide binding]; other site 272562007410 conserved gate region; other site 272562007411 putative PBP binding loops; other site 272562007412 ABC-ATPase subunit interface; other site 272562007413 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppB; COG0601 272562007414 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 272562007415 dimer interface [polypeptide binding]; other site 272562007416 conserved gate region; other site 272562007417 putative PBP binding loops; other site 272562007418 ABC-ATPase subunit interface; other site 272562007419 Dihydrodipicolinate synthase (DHDPS); Region: DHDPS; cd00950 272562007420 dimer interface [polypeptide binding]; other site 272562007421 active site 272562007422 catalytic residue [active] 272562007423 Dihydrodipicolinate reductase [Amino acid transport and metabolism]; Region: DapB; COG0289 272562007424 Dihydrodipicolinate reductase, N-terminus; Region: DapB_N; pfam01113 272562007425 Dihydrodipicolinate reductase, C-terminus; Region: DapB_C; pfam05173 272562007426 aminotransferase A; Validated; Region: PRK07683 272562007427 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 272562007428 pyridoxal 5'-phosphate binding site [chemical binding]; other site 272562007429 homodimer interface [polypeptide binding]; other site 272562007430 catalytic residue [active] 272562007431 Tetrahydrodipicolinate succinyltransferase N-terminal; Region: DapH_N; pfam08503 272562007432 2,3,4,5-tetrahydropyridine-2,6-dicarboxylate N-acetyltransferase; Region: DapD_Ac; TIGR03532 272562007433 2,3,4,5-tetrahydropyridine-2,6-dicarboxylate (THDP) N-succinyltransferase (also called THP succinyltransferase): THDP N-succinyltransferase catalyzes the conversion of tetrahydrodipicolinate and succinyl-CoA to N-succinyltetrahydrodipicolinate and CoA; Region: LbH_THP_succinylT; cd03350 272562007434 trimer interface [polypeptide binding]; other site 272562007435 active site 272562007436 substrate binding site [chemical binding]; other site 272562007437 CoA binding site [chemical binding]; other site 272562007438 single-stranded DNA-binding protein; Provisional; Region: PRK05813 272562007439 SSB_OBF: A subfamily of OB folds similar to the OB fold of ssDNA-binding protein (SSB). SSBs bind with high affinity to ssDNA. They bind to and protect ssDNA intermediates during DNA metabolic pathways. All bacterial and eukaryotic SSBs studied to date...; Region: SSB_OBF; cd04496 272562007440 dimer interface [polypeptide binding]; other site 272562007441 ssDNA binding site [nucleotide binding]; other site 272562007442 tetramer (dimer of dimers) interface [polypeptide binding]; other site 272562007443 Predicted xylanase/chitin deacetylase [Carbohydrate transport and metabolism]; Region: CDA1; COG0726 272562007444 Catalytic NodB homology domain of rhizobial NodB-like proteins; Region: CE4_NodB_like_6s_7s; cd10917 272562007445 NodB motif; other site 272562007446 active site 272562007447 catalytic site [active] 272562007448 metal binding site [ion binding]; metal-binding site 272562007449 Domain of unknown function (DUF4364); Region: DUF4364; pfam14277 272562007450 Uncharacterized conserved protein [Function unknown]; Region: COG3391 272562007451 TSCPD domain; Region: TSCPD; cl14834 272562007452 Adenosylmethionine-8-amino-7-oxononanoate aminotransferase [Coenzyme metabolism]; Region: BioA; COG0161 272562007453 Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610 272562007454 inhibitor-cofactor binding pocket; inhibition site 272562007455 pyridoxal 5'-phosphate binding site [chemical binding]; other site 272562007456 catalytic residue [active] 272562007457 AAK_NAGK-C: N-Acetyl-L-glutamate kinase - cyclic (NAGK-C) catalyzes the phosphorylation of the gamma-COOH group of N-acetyl-L-glutamate (NAG) by ATP in the second step of arginine biosynthesis found in some bacteria and photosynthetic organisms using the...; Region: AAK_NAGK-C; cd04250 272562007458 homohexameric interface [polypeptide binding]; other site 272562007459 feedback inhibition sensing region; other site 272562007460 nucleotide binding site [chemical binding]; other site 272562007461 N-acetyl-L-glutamate binding site [chemical binding]; other site 272562007462 N-acetyl-gamma-glutamyl-phosphate reductase; Validated; Region: argC; PRK00436 272562007463 Semialdehyde dehydrogenase, NAD binding domain; Region: Semialdhyde_dh; pfam01118 272562007464 Semialdehyde dehydrogenase, dimerization domain; Region: Semialdhyde_dhC; pfam02774 272562007465 Ornithine acetyltransferase (OAT) family; also referred to as ArgJ. OAT catalyzes the first and fifth steps in arginine biosynthesis, coupling acetylation of glutamate with deacetylation of N-acetylornithine, which allows recycling of the acetyl group in...; Region: OAT; cd02152 272562007466 heterotetramer interface [polypeptide binding]; other site 272562007467 active site pocket [active] 272562007468 cleavage site 272562007469 ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132 272562007470 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 272562007471 ATP-binding cassette domain of glucan transporter and related proteins, subfamily C; Region: ABCC_Glucan_exporter_like; cd03254 272562007472 Walker A/P-loop; other site 272562007473 ATP binding site [chemical binding]; other site 272562007474 Q-loop/lid; other site 272562007475 ABC transporter signature motif; other site 272562007476 Walker B; other site 272562007477 D-loop; other site 272562007478 H-loop/switch region; other site 272562007479 ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132 272562007480 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 272562007481 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 272562007482 Walker A/P-loop; other site 272562007483 ATP binding site [chemical binding]; other site 272562007484 Q-loop/lid; other site 272562007485 ABC transporter signature motif; other site 272562007486 Walker B; other site 272562007487 D-loop; other site 272562007488 H-loop/switch region; other site 272562007489 Transcriptional regulator [Transcription]; Region: LysR; COG0583 272562007490 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 272562007491 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cd05466 272562007492 dimerization interface [polypeptide binding]; other site 272562007493 Membrane-associated phospholipid phosphatase [Lipid metabolism]; Region: PgpB; COG0671 272562007494 PAP2_like proteins, BcrC_like subfamily. Several members of this family have been annotated as bacitracin transport permeases, as it was suspected that they form the permease component of an ABC transporter system. It was shown, however, that BcrC from...; Region: PAP2_BcrC_like; cd03385 272562007495 active site 272562007496 Predicted xylanase/chitin deacetylase [Carbohydrate transport and metabolism]; Region: CDA1; COG0726 272562007497 Catalytic NodB homology domain of Streptococcus mutans polysaccharide deacetylase PgdA, Bacillus subtilis YheN, and similar proteins; Region: CE4_SmPgdA_like; cd10944 272562007498 NodB motif; other site 272562007499 active site 272562007500 catalytic site [active] 272562007501 Zn binding site [ion binding]; other site 272562007502 S1_like: Ribosomal protein S1-like RNA-binding domain. Found in a wide variety of RNA-associated proteins. Originally identified in S1 ribosomal protein. This superfamily also contains the Cold Shock Domain (CSD), which is a homolog of the S1 domain; Region: S1_like; cl09927 272562007503 Folylpolyglutamate synthase [Coenzyme metabolism]; Region: FolC; COG0285 272562007504 Mur ligase middle domain; Region: Mur_ligase_M; pfam08245 272562007505 Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875 272562007506 valyl-tRNA synthetase; Reviewed; Region: valS; PRK05729 272562007507 catalytic core domain of valyl-tRNA synthetases; Region: ValRS_core; cd00817 272562007508 active site 272562007509 HIGH motif; other site 272562007510 Leucyl-tRNA synthetase, Domain 2; Region: tRNA-synt_1_2; pfam13603 272562007511 KMSKS motif; other site 272562007512 Anticodon-binding domain of valyl tRNA synthetases; Region: Anticodon_Ia_Val; cd07962 272562007513 tRNA binding surface [nucleotide binding]; other site 272562007514 anticodon binding site; other site 272562007515 Valyl tRNA synthetase tRNA binding arm; Region: Val_tRNA-synt_C; pfam10458 272562007516 Protein Kinases, catalytic domain; Region: PKc_like; cl09925 272562007517 active site 272562007518 ATP binding site [chemical binding]; other site 272562007519 BadF/BadG/BcrA/BcrD ATPase family; Region: BcrAD_BadFG; cl17271 272562007520 Activator of 2-hydroxyglutaryl-CoA dehydratase (HSP70-class ATPase domain) [Lipid metabolism]; Region: COG1924 272562007521 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3580 272562007522 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3581 272562007523 Tetratricopeptide repeat; Region: TPR_12; pfam13424 272562007524 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 272562007525 binding surface 272562007526 TPR motif; other site 272562007527 TPR repeat; Region: TPR_11; pfam13414 272562007528 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 272562007529 putative substrate translocation pore; other site 272562007530 Carbohydrate Binding Module 6 (CBM6) and CBM35_like superfamily; Region: CBM6-CBM35-CBM36_like; cl14880 272562007531 Glycosyltransferases involved in cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WcaA; COG0463 272562007532 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cd00761 272562007533 active site 272562007534 This family is most closely related to the GT1 family of glycosyltransferases and named after YqgM in Bacillus licheniformis about which little is known. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to...; Region: GT1_YqgM_like; cd03801 272562007535 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 272562007536 Multidrug and toxic compound extrusion family and similar proteins; Region: MATE_like; cl09326 272562007537 Membrane protein involved in the export of O-antigen and teichoic acid [General function prediction only]; Region: RfbX; COG2244 272562007538 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 272562007539 active site 272562007540 phosphorylation site [posttranslational modification] 272562007541 intermolecular recognition site; other site 272562007542 dimerization interface [polypeptide binding]; other site 272562007543 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394 272562007544 active site 272562007545 Colicin V production protein; Region: Colicin_V; pfam02674 272562007546 Transglutaminase-like enzymes, putative cysteine proteases [Amino acid transport and metabolism]; Region: COG1305 272562007547 Transglutaminase-like superfamily; Region: Transglut_core; pfam01841 272562007548 RecX family; Region: RecX; cl00936 272562007549 Predicted Zn-dependent peptidases [General function prediction only]; Region: PqqL; COG0612 272562007550 Insulinase (Peptidase family M16); Region: Peptidase_M16; pfam00675 272562007551 Peptidase M16 inactive domain; Region: Peptidase_M16_C; pfam05193 272562007552 Uncharacterized conserved protein [Function unknown]; Region: COG4127 272562007553 Predicted membrane protein [Function unknown]; Region: COG4708 272562007554 Uncharacterized conserved protein [Function unknown]; Region: COG1543 272562007555 N-terminal catalytic domain of alpha-amylase ( AmyC ) and similar proteins; Region: GH57N_AmyC_like; cd10792 272562007556 active site 272562007557 substrate binding site [chemical binding]; other site 272562007558 catalytic site [active] 272562007559 Domain of unknown function (DUF1957); Region: DUF1957; pfam09210 272562007560 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3330 272562007561 Uncharacterized protein conserved in bacteria [Function unknown]; Region: ErfK; COG1376 272562007562 L,D-transpeptidase catalytic domain; Region: YkuD; pfam03734 272562007563 Putative peptidoglycan binding domain; Region: PG_binding_1; pfam01471 272562007564 Cache domain; Region: Cache_1; pfam02743 272562007565 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 272562007566 dimerization interface [polypeptide binding]; other site 272562007567 Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer); Region: MA; smart00283 272562007568 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cl19050 272562007569 dimer interface [polypeptide binding]; other site 272562007570 putative CheW interface [polypeptide binding]; other site 272562007571 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 272562007572 Radical SAM superfamily; Region: Radical_SAM; pfam04055 272562007573 FeS/SAM binding site; other site 272562007574 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 272562007575 haloacid dehalogenase-like hydrolase; Region: Hydrolase_3; pfam08282 272562007576 active site 272562007577 motif I; other site 272562007578 motif II; other site 272562007579 haloacid dehalogenase-like hydrolase; Region: HAD; cl19137 272562007580 Predicted esterase of the alpha-beta hydrolase superfamily [General function prediction only]; Region: COG4667 272562007581 Hypothetical patatin similar to yjju protein of Escherichia coli; Region: Pat_hypo_Ecoli_yjju_like; cd07208 272562007582 active site 272562007583 nucleophile elbow; other site 272562007584 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3580 272562007585 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3581 272562007586 Activator of 2-hydroxyglutaryl-CoA dehydratase (HSP70-class ATPase domain) [Lipid metabolism]; Region: COG1924 272562007587 PilZ domain; Region: PilZ; pfam07238 272562007588 transcription elongation factor GreA; Region: greA; TIGR01462 272562007589 Transcription elongation factor, N-terminal; Region: GreA_GreB_N; pfam03449 272562007590 Transcription elongation factor, GreA/GreB, C-term; Region: GreA_GreB; pfam01272 272562007591 Phosphoglycerol transferase and related proteins, alkaline phosphatase superfamily [Cell envelope biogenesis, outer membrane]; Region: MdoB; COG1368 272562007592 Sulfatase; Region: Sulfatase; pfam00884 272562007593 Predicted permease, member of the PurR regulon [General function prediction only]; Region: yhhT; COG0628 272562007594 Protein of unknown function (DUF1190); Region: DUF1190; cl10031 272562007595 Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain [Posttranslational modification, protein turnover, chaperones]; Region: DegQ; COG0265 272562007596 Trypsin-like peptidase domain; Region: Trypsin_2; pfam13365 272562007597 PDZ domain of trypsin-like serine proteases, such as DegP/HtrA, which are oligomeric proteins involved in heat-shock response, chaperone function, and apoptosis. May be responsible for substrate recognition and/or binding, as most PDZ domains bind...; Region: PDZ_serine_protease; cd00987 272562007598 protein binding site [polypeptide binding]; other site 272562007599 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 272562007600 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 272562007601 dimerization interface [polypeptide binding]; other site 272562007602 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 272562007603 dimer interface [polypeptide binding]; other site 272562007604 phosphorylation site [posttranslational modification] 272562007605 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 272562007606 ATP binding site [chemical binding]; other site 272562007607 Mg2+ binding site [ion binding]; other site 272562007608 G-X-G motif; other site 272562007609 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 272562007610 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 272562007611 active site 272562007612 phosphorylation site [posttranslational modification] 272562007613 intermolecular recognition site; other site 272562007614 dimerization interface [polypeptide binding]; other site 272562007615 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 272562007616 DNA binding site [nucleotide binding] 272562007617 Predicted multitransmembrane protein [Function unknown]; Region: COG5438 272562007618 Conserved protein/domain typically associated with flavoprotein oxygenases, DIM6/NTAB family [General function prediction only]; Region: COG1853 272562007619 PAP2_like proteins, a super-family of histidine phosphatases and vanadium haloperoxidases, includes type 2 phosphatidic acid phosphatase or lipid phosphate phosphatase (LPP), Glucose-6-phosphatase, Phosphatidylglycerophosphatase B and bacterial acid...; Region: PAP2_like; cl00474 272562007620 Membrane-associated phospholipid phosphatase [Lipid metabolism]; Region: PgpB; COG0671 272562007621 active site 272562007622 Copper amine oxidase N-terminal domain; Region: Cu_amine_oxidN1; pfam07833 272562007623 Periplasmic binding protein TroA_d. These proteins are predicted to function as initial receptors in the ABC metal ion uptake in eubacteria and archaea. They belong to the TroA superfamily of helical backbone metal receptor proteins that share a...; Region: TroA_d; cd01141 272562007624 putative ligand binding site [chemical binding]; other site 272562007625 ABC-type Fe3+-hydroxamate transport system, periplasmic component [Inorganic ion transport and metabolism]; Region: FepB; COG0614 272562007626 Helical backbone metal receptor (TroA-like domain). These proteins have been shown to function in the ABC transport of ferric siderophores and metal ions such as Mn2+, Fe3+, Cu2+ and/or Zn2+. Their ligand binding site is formed in the interface between...; Region: TroA-like; cl00262 272562007627 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550 272562007628 ABC-ATPase subunit interface; other site 272562007629 dimer interface [polypeptide binding]; other site 272562007630 putative PBP binding regions; other site 272562007631 ABC-type cobalamin/Fe3+-siderophores transport systems, ATPase components [Inorganic ion transport and metabolism / Coenzyme metabolism]; Region: FepC; COG1120 272562007632 ATP-binding component of iron-siderophores, vitamin B12 and hemin transporters and related proteins; Region: ABC_Iron-Siderophores_B12_Hemin; cd03214 272562007633 Walker A/P-loop; other site 272562007634 ATP binding site [chemical binding]; other site 272562007635 Q-loop/lid; other site 272562007636 ABC transporter signature motif; other site 272562007637 Walker B; other site 272562007638 D-loop; other site 272562007639 H-loop/switch region; other site 272562007640 Uncharacterized protein containing a Zn-finger-like domain [General function prediction only]; Region: COG2158 272562007641 5-aminoimidazole-4-carboxamide ribonucleotide transformylase; Provisional; Region: PRK07106 272562007642 AICAR transformylase/IMP cyclohydrolase PurH (only IMP cyclohydrolase domain in Aful) [Nucleotide transport and metabolism]; Region: PurH; COG0138 272562007643 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox_2; pfam07992 272562007644 Uncharacterized flavoproteins [Energy production and conversion]; Region: FpaA; COG0426 272562007645 Metallo-beta-lactamase superfamily; Region: Lactamase_B; smart00849 272562007646 NADPH-dependent FMN reductase; Region: FMN_red; cl00438 272562007647 Desulfoferrodoxin [Energy production and conversion]; Region: COG2033 272562007648 Superoxide reductase-like (SORL) domain; present in a family of mononuclear non-heme iron proteins that includes superoxide reductase and desulfoferrodoxin. Superoxide reductase-like proteins scavenge superoxide anion radicals as a defense mechanism...; Region: SORL; cd00524 272562007649 non-heme iron binding site [ion binding]; other site 272562007650 Predicted transcriptional regulators [Transcription]; Region: SoxR; COG0789 272562007651 Helix-Turn-Helix DNA binding domain of MerR-like transcription regulators; Region: HTH_MerR-like; cd00592 272562007652 DNA binding residues [nucleotide binding] 272562007653 dimer interface [polypeptide binding]; other site 272562007654 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 272562007655 S-adenosylmethionine binding site [chemical binding]; other site 272562007656 flavodoxin; Provisional; Region: PRK05569 272562007657 Uncharacterized flavoproteins [Energy production and conversion]; Region: FpaA; COG0426 272562007658 The CBS domain, named after human CBS, is a small domain originally identified in cystathionine beta-synthase and is subsequently found in a wide range of different proteins. CBS domains usually occur in tandem repeats. They associate to form a so-called...; Region: CBS_pair; cl15354 272562007659 Bacterial PH domain; Region: bPH_3; pfam14470 272562007660 2-oxoacid:acceptor oxidoreductase, beta subunit, pyruvate/2-ketoisovalerate family; Region: PorB_KorB; TIGR02177 272562007661 Thiamine pyrophosphate (TPP family), 2-oxoglutarate ferredoxin oxidoreductase (OGFOR) subfamily, TPP-binding module; OGFOR catalyzes the oxidative decarboxylation of 2-oxo-acids, with ferredoxin acting as an electron acceptor. In the TCA cycle, OGFOR...; Region: TPP_OGFOR; cd03375 272562007662 TPP-binding site [chemical binding]; other site 272562007663 Pyruvate ferredoxin oxidoreductase beta subunit C terminal; Region: PFO_beta_C; pfam12367 272562007664 2-oxoacid:acceptor oxidoreductase, alpha subunit; Region: OAFO_sf; TIGR03710 272562007665 Pyruvate ferredoxin/flavodoxin oxidoreductase; Region: POR; pfam01558 272562007666 Pyrimidine (PYR) binding domain of pyruvate ferredoxin oxidoreductase (PFOR), indolepyruvate ferredoxin oxidoreductase alpha subunit (IOR-alpha), and related proteins; Region: TPP_PYR_PFOR_IOR-alpha_like; cd07034 272562007667 dimer interface [polypeptide binding]; other site 272562007668 PYR/PP interface [polypeptide binding]; other site 272562007669 TPP binding site [chemical binding]; other site 272562007670 substrate binding site [chemical binding]; other site 272562007671 Pleckstrin homology-like domain; Region: PH-like; cl17171 272562007672 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3220 272562007673 Bleomycin binding protein (BLMA) and similar proteins; BLMA confers bleomycin (Bm) resistance by directly binding to Bm; Region: BLMA_like; cd08349 272562007674 dimer interface [polypeptide binding]; other site 272562007675 ligand binding site [chemical binding]; other site 272562007676 Predicted secreted protein [Function unknown]; Region: COG5513 272562007677 Acetyltransferase (GNAT) domain; Region: Acetyltransf_10; pfam13673 272562007678 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 272562007679 Coenzyme A binding pocket [chemical binding]; other site 272562007680 Putative zinc ribbon domain; Region: Zn_ribbon_2; pfam12674 272562007681 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 272562007682 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 272562007683 non-specific DNA binding site [nucleotide binding]; other site 272562007684 salt bridge; other site 272562007685 sequence-specific DNA binding site [nucleotide binding]; other site 272562007686 Polypeptide or peptide deformylase; a family of metalloenzymes that catalyzes the removal of the N-terminal formyl group in a growing polypeptide chain following translation initiation during protein synthesis in prokaryotes. These enzymes utilize Fe(II)...; Region: Pep_deformylase; cd00487 272562007687 active site 272562007688 catalytic residues [active] 272562007689 metal binding site [ion binding]; metal-binding site 272562007690 Predicted flavin-nucleotide-binding protein [General function prediction only]; Region: COG3467 272562007691 Regulator of competence-specific genes [Transcription]; Region: TfoX; COG3070 272562007692 NlpC/P60 family; Region: NLPC_P60; cl17555 272562007693 CAAX protease self-immunity; Region: Abi; pfam02517 272562007694 Acetyltransferases, including N-acetylases of ribosomal proteins [Translation, ribosomal structure and biogenesis]; Region: RimL; COG1670 272562007695 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 272562007696 Coenzyme A binding pocket [chemical binding]; other site 272562007697 topology modulation protein; Reviewed; Region: PRK08118 272562007698 Adenylate kinase and related kinases [Nucleotide transport and metabolism]; Region: Adk; COG0563 272562007699 Carbonic anhydrases (CA) are zinc-containing enzymes that catalyze the reversible hydration of carbon dioxide in a two-step mechanism in which the nucleophilic attack of a zinc-bound hydroxide ion on carbon dioxide is followed by the regeneration of an...; Region: beta_CA_cladeC; cd03378 272562007700 active site clefts [active] 272562007701 zinc binding site [ion binding]; other site 272562007702 dimer interface [polypeptide binding]; other site 272562007703 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cl19050 272562007704 dimer interface [polypeptide binding]; other site 272562007705 putative CheW interface [polypeptide binding]; other site 272562007706 Predicted membrane protein [Function unknown]; Region: COG4129 272562007707 Bacterial protein of unknown function (DUF939); Region: DUF939; pfam06081 272562007708 DUF939 C-terminal domain; Region: DUF939_C; pfam11728 272562007709 Na+-driven multidrug efflux pump [Defense mechanisms]; Region: NorM; COG0534 272562007710 Subfamily of the multidrug and toxic compound extrusion (MATE)-like proteins similar to Streptococcus aureus MepA; Region: MATE_MepA_like; cd13143 272562007711 Transcriptional regulators [Transcription]; Region: MarR; COG1846 272562007712 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cl17220 272562007713 Acetyltransferase (GNAT) domain; Region: Acetyltransf_3; pfam13302 272562007714 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 272562007715 Coenzyme A binding pocket [chemical binding]; other site 272562007716 Uncharacterized conserved protein [Function unknown]; Region: COG3945 272562007717 Fe binding site [ion binding]; other site 272562007718 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 272562007719 non-specific DNA binding site [nucleotide binding]; other site 272562007720 salt bridge; other site 272562007721 sequence-specific DNA binding site [nucleotide binding]; other site 272562007722 Tetratricopeptide repeat; Region: TPR_12; pfam13424 272562007723 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 272562007724 binding surface 272562007725 TPR motif; other site 272562007726 Tetratricopeptide repeat; Region: TPR_12; pfam13424 272562007727 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 272562007728 Coenzyme A binding pocket [chemical binding]; other site 272562007729 Zinc dependent phospholipase C; Region: Zn_dep_PLPC; pfam00882 272562007730 PLAT (Polycystin-1, Lipoxygenase, Alpha-Toxin) domain or LH2 (Lipoxygenase homology 2) domain. It consists of an eight stranded beta-barrel. The domain can be found in various domain architectures, in case of lipoxygenases, alpha toxin, lipases and...; Region: PLAT; cl00011 272562007731 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 272562007732 non-specific DNA binding site [nucleotide binding]; other site 272562007733 salt bridge; other site 272562007734 sequence-specific DNA binding site [nucleotide binding]; other site 272562007735 Predicted phosphatases [General function prediction only]; Region: Gph; COG0546 272562007736 haloacid dehalogenase superfamily, subfamily IA, variant 1 with third motif having Dx(3-4)D or Dx(3-4)E; Region: HAD-SF-IA-v1; TIGR01549 272562007737 Carbon monoxide dehydrogenase (CODH) is found in acetogenic and methanogenic organisms and is responsible for the synthesis and breakdown of acetyl-CoA, respectively. CODH has two types of metal clusters, a cubane [Fe4-S4] center (B-cluster) similar to...; Region: CODH; cd01915 272562007738 ACS interaction site; other site 272562007739 CODH interaction site; other site 272562007740 cubane metal cluster (B-cluster) [ion binding]; other site 272562007741 Ni-Fe-S cluster (C-cluster) [ion binding]; other site 272562007742 pyruvate:ferredoxin (flavodoxin) oxidoreductase, homodimeric; Region: pyruv_ox_red; TIGR02176 272562007743 Pyrimidine (PYR) binding domain of pyruvate ferredoxin oxidoreductase (PFOR), indolepyruvate ferredoxin oxidoreductase alpha subunit (IOR-alpha), and related proteins; Region: TPP_PYR_PFOR_IOR-alpha_like; cd07034 272562007744 dimer interface [polypeptide binding]; other site 272562007745 PYR/PP interface [polypeptide binding]; other site 272562007746 TPP binding site [chemical binding]; other site 272562007747 substrate binding site [chemical binding]; other site 272562007748 Pyruvate:ferredoxin oxidoreductase and related 2-oxoacid:ferredoxin oxidoreductases, gamma subunit [Energy production and conversion]; Region: PorG; COG1014 272562007749 Domain of unknown function; Region: EKR; smart00890 272562007750 4Fe-4S double cluster binding domain; Region: Fer4_16; pfam13484 272562007751 Thiamine pyrophosphate (TPP family), PFOR_PNO subfamily, TPP-binding module; composed of proteins similar to the single subunit pyruvate ferredoxin oxidoreductase (PFOR) of Desulfovibrio Africanus, present in bacteria and amitochondriate eukaryotes. This...; Region: TPP_PFOR_PNO; cd03377 272562007752 TPP-binding site [chemical binding]; other site 272562007753 dimer interface [polypeptide binding]; other site 272562007754 membrane protein; Provisional; Region: PRK14413 272562007755 4-amino-4-deoxy-L-arabinose-phosphoundecaprenol flippase subunit ArnF; Provisional; Region: PRK02971 272562007756 4-amino-4-deoxy-L-arabinose-phosphoundecaprenol flippase subunit ArnE; Provisional; Region: PRK15051 272562007757 Domain of unknown function (DUF3787); Region: DUF3787; pfam12655 272562007758 hopanoid biosynthesis associated RND transporter like protein HpnN; Region: HpnN; TIGR03480 272562007759 Sporulation protein and related proteins [Cell division and chromosome partitioning]; Region: SpoIID; COG2385 272562007760 Stage II sporulation protein; Region: SpoIID; pfam08486 272562007761 Y_Y_Y domain; Region: Y_Y_Y; pfam07495 272562007762 Y_Y_Y domain; Region: Y_Y_Y; pfam07495 272562007763 Y_Y_Y domain; Region: Y_Y_Y; pfam07495 272562007764 Y_Y_Y domain; Region: Y_Y_Y; pfam07495 272562007765 Putative peptidoglycan-binding domain-containing protein [Cell envelope biogenesis, outer membrane]; Region: COG3409 272562007766 Putative peptidoglycan binding domain; Region: PG_binding_1; pfam01471 272562007767 Putative peptidoglycan binding domain; Region: PG_binding_1; pfam01471 272562007768 Nitroreductase-like family 3. A subfamily of the nitroreductase family containing uncharacterized proteins that are similar to nitroreductase. Nitroreductase catalyzes the reduction of nitroaromatic compounds such as nitrotoluenes, nitrofurans and...; Region: Nitroreductase_3; cd02139 272562007769 putative FMN binding site [chemical binding]; other site 272562007770 Acetyltransferases [General function prediction only]; Region: RimI; COG0456 272562007771 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 272562007772 Coenzyme A binding pocket [chemical binding]; other site 272562007773 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl17182 272562007774 Domain of unknown function (DUF3784); Region: DUF3784; pfam12650 272562007775 Beta-galactosidase [Carbohydrate transport and metabolism]; Region: LacA; COG1874 272562007776 Glycosyl hydrolases family 35; Region: Glyco_hydro_35; pfam01301 272562007777 Beta-galactosidase, domain 2; Region: BetaGal_dom2; smart01029 272562007778 Beta-galactosidase, domain 3; Region: BetaGal_dom3; pfam13363 272562007779 Beta-galactosidase jelly roll domain; Region: BetaGal_dom4_5; pfam13364 272562007780 Beta-galactosidase jelly roll domain; Region: BetaGal_dom4_5; pfam13364 272562007781 Zinc metalloprotease (elastase) [Amino acid transport and metabolism]; Region: LasB; COG3227 272562007782 Fungalysin/Thermolysin Propeptide Motif; Region: FTP; pfam07504 272562007783 Peptidase propeptide and YPEB domain; Region: PepSY; pfam03413 272562007784 Peptidase M4 family includes thermolysin, protealysin, aureolysin and neutral protease; Region: M4_neutral_protease; cd09597 272562007785 active site 272562007786 Zn binding site [ion binding]; other site 272562007787 Zinc metalloprotease (elastase) [Amino acid transport and metabolism]; Region: LasB; COG3227 272562007788 Fungalysin/Thermolysin Propeptide Motif; Region: FTP; pfam07504 272562007789 Peptidase propeptide and YPEB domain; Region: PepSY; pfam03413 272562007790 Multimeric flavodoxin WrbA [General function prediction only]; Region: WrbA; COG0655 272562007791 Glycosyltransferases involved in cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WcaA; COG0463 272562007792 DPM_DPG-synthase_like is a member of the Glycosyltransferase 2 superfamily; Region: DPM_DPG-synthase_like; cd04179 272562007793 Ligand binding site; other site 272562007794 Putative Catalytic site; other site 272562007795 DXD motif; other site 272562007796 putative glycosyltransferase, exosortase G-associated; Region: glyc2_xrt_Gpos1; TIGR03111 272562007797 CESA_like is the cellulose synthase superfamily; Region: CESA_like; cd06423 272562007798 DXD motif; other site 272562007799 exosortase family protein XrtG; Region: exosort_Gpos; TIGR03110 272562007800 Predicted integral membrane protein [Function unknown]; Region: COG5617 272562007801 6-pyruvoyl tetrahydropterin synthase-related domain; Region: 6_pyr_pter_rel; TIGR03112 272562007802 Multimeric flavodoxin WrbA [General function prediction only]; Region: WrbA; COG0655 272562007803 Acetyltransferase (GNAT) family; Region: Acetyltransf_1; pfam00583 272562007804 Acetyltransferase (GNAT) family; Region: Acetyltransf_1; pfam00583 272562007805 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 272562007806 S-adenosylmethionine binding site [chemical binding]; other site 272562007807 Bacterial surface proteins containing Ig-like domains [Cell motility and secretion]; Region: COG5492 272562007808 Clostridial hydrophobic, with a conserved W residue, domain; Region: ChW; smart00728 272562007809 Clostridial hydrophobic, with a conserved W residue, domain; Region: ChW; smart00728 272562007810 Clostridial hydrophobic, with a conserved W residue, domain; Region: ChW; smart00728 272562007811 Clostridial hydrophobic, with a conserved W residue, domain; Region: ChW; smart00728 272562007812 Clostridial hydrophobic, with a conserved W residue, domain; Region: ChW; smart00728 272562007813 Clostridial hydrophobic, with a conserved W residue, domain; Region: ChW; smart00728 272562007814 Bacterial surface proteins containing Ig-like domains [Cell motility and secretion]; Region: COG5492 272562007815 Clostridial hydrophobic, with a conserved W residue, domain; Region: ChW; smart00728 272562007816 Clostridial hydrophobic, with a conserved W residue, domain; Region: ChW; smart00728 272562007817 Clostridial hydrophobic, with a conserved W residue, domain; Region: ChW; smart00728 272562007818 Clostridial hydrophobic, with a conserved W residue, domain; Region: ChW; smart00728 272562007819 Clostridial hydrophobic, with a conserved W residue, domain; Region: ChW; smart00728 272562007820 Clostridial hydrophobic, with a conserved W residue, domain; Region: ChW; smart00728 272562007821 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 272562007822 Zn2+ binding site [ion binding]; other site 272562007823 c-di-GMP phosphodiesterase class II (HD-GYP domain) [Signal transduction mechanisms]; Region: COG2206 272562007824 Mg2+ binding site [ion binding]; other site 272562007825 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 272562007826 Zn2+ binding site [ion binding]; other site 272562007827 Mg2+ binding site [ion binding]; other site 272562007828 PQQ-dependent catabolism-associated beta-propeller protein; Region: PQQ_ABC_repeats; TIGR03866 272562007829 40-residue YVTN family beta-propeller repeat; Region: beta_rpt_yvtn; TIGR02276 272562007830 WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from...; Region: WD40; cd00200 272562007831 structural tetrad; other site 272562007832 40-residue YVTN family beta-propeller repeat; Region: beta_rpt_yvtn; TIGR02276 272562007833 40-residue YVTN family beta-propeller repeat; Region: beta_rpt_yvtn; TIGR02276 272562007834 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 272562007835 This family is most closely related to the GT1 family of glycosyltransferases. UDP-glucose-diacylglycerol glucosyltransferase (UGDG; also known as 1,2-diacylglycerol 3-glucosyltransferase) catalyzes the transfer of glucose from UDP-glucose to 1; Region: GT1_UGDG_like; cd03817 272562007836 putative ADP-binding pocket [chemical binding]; other site 272562007837 PAP2_like proteins, BcrC_like subfamily. Several members of this family have been annotated as bacitracin transport permeases, as it was suspected that they form the permease component of an ABC transporter system. It was shown, however, that BcrC from...; Region: PAP2_BcrC_like; cd03385 272562007838 Membrane-associated phospholipid phosphatase [Lipid metabolism]; Region: PgpB; COG0671 272562007839 active site 272562007840 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 272562007841 Acetyltransferases [General function prediction only]; Region: RimI; COG0456 272562007842 Coenzyme A binding pocket [chemical binding]; other site 272562007843 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl17182 272562007844 Co/Zn/Cd efflux system component [Inorganic ion transport and metabolism]; Region: CzcD; COG1230 272562007845 Translation_Factor_II_like: Elongation factor Tu (EF-Tu) domain II-like proteins. Elongation factor Tu consists of three structural domains, this family represents the second domain. Domain II adopts a beta barrel structure and is involved in binding to...; Region: Translation_Factor_II_like; cd01342 272562007846 FAD binding domain; Region: FAD_binding_4; pfam01565 272562007847 glycolate oxidase, subunit GlcD; Region: glcD; TIGR00387 272562007848 FAD linked oxidases, C-terminal domain; Region: FAD-oxidase_C; pfam02913 272562007849 Ferredoxin [Energy production and conversion]; Region: NapF; COG1145 272562007850 Electron transfer flavoprotein, alpha subunit [Energy production and conversion]; Region: FixB; COG2025 272562007851 The electron transfer flavoprotein (ETF) serves as a specific electron acceptor for various mitochondrial dehydrogenases. ETF transfers electrons to the main respiratory chain via ETF-ubiquinone oxidoreductase. ETF is an heterodimer that consists of an...; Region: ETF_alpha; cd01715 272562007852 Electron transfer flavoprotein FAD-binding domain; Region: ETF_alpha; pfam00766 272562007853 The electron transfer flavoprotein (ETF) serves as a specific electron acceptor for various mitochondrial dehydrogenases. ETF transfers electrons to the main respiratory chain via ETF-ubiquinone oxidoreductase. ETF is an heterodimer that consists of an...; Region: ETF_beta; cd01714 272562007854 Ligand binding site [chemical binding]; other site 272562007855 Transcriptional regulators [Transcription]; Region: FadR; COG2186 272562007856 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 272562007857 DNA-binding site [nucleotide binding]; DNA binding site 272562007858 This entry represents the C-terminal ligand binding domain of many members of the GntR family; Region: FCD; smart00895 272562007859 ligand binding domain of Tar- and Tsr-related chemoreceptors; Region: Tar_Tsr_LBD; cl00144 272562007860 Cache domain; Region: Cache_1; pfam02743 272562007861 Methyl-accepting chemotaxis protein [Cell motility and secretion / Signal transduction mechanisms]; Region: Tar; COG0840 272562007862 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 272562007863 dimerization interface [polypeptide binding]; other site 272562007864 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 272562007865 dimer interface [polypeptide binding]; other site 272562007866 putative CheW interface [polypeptide binding]; other site 272562007867 Translation_Factor_II_like: Elongation factor Tu (EF-Tu) domain II-like proteins. Elongation factor Tu consists of three structural domains, this family represents the second domain. Domain II adopts a beta barrel structure and is involved in binding to...; Region: Translation_Factor_II_like; cl02787 272562007868 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4295 272562007869 Domain of unknown function (DUF1848); Region: DUF1848; pfam08902 272562007870 Predicted double-stranded RNA/RNA-DNA hybrid binding protein [General function prediction only]; Region: COG3341 272562007871 Caulimovirus viroplasmin; Region: Cauli_VI; pfam01693 272562007872 Bacterial RNase HI containing a hybrid binding domain (HBD) at the N-terminus; Region: RNase_HI_bacteria_like; cd09277 272562007873 RNA/DNA hybrid binding site [nucleotide binding]; other site 272562007874 active site 272562007875 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 272562007876 salt bridge; other site 272562007877 non-specific DNA binding site [nucleotide binding]; other site 272562007878 sequence-specific DNA binding site [nucleotide binding]; other site 272562007879 Protein of unknown function (DUF2975); Region: DUF2975; pfam11188 272562007880 Beta-mannanase [Carbohydrate transport and metabolism]; Region: ManB; COG4124 272562007881 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4994 272562007882 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 272562007883 Coenzyme A binding pocket [chemical binding]; other site 272562007884 Acetyltransferases, including N-acetylases of ribosomal proteins [Translation, ribosomal structure and biogenesis]; Region: RimL; COG1670 272562007885 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 272562007886 Coenzyme A binding pocket [chemical binding]; other site 272562007887 GGGtGRT protein; Region: GGGtGRT; pfam14057 272562007888 NifU homolog involved in Fe-S cluster formation [Energy production and conversion]; Region: IscU; COG0822 272562007889 FtsJ-like methyltransferase; Region: FtsJ; cl17430 272562007890 Putative rRNA methylase; Region: rRNA_methylase; pfam06962 272562007891 Superoxide dismutase [Inorganic ion transport and metabolism]; Region: SodA; COG0605 272562007892 Iron/manganese superoxide dismutases, C-terminal domain; Region: Sod_Fe_C; pfam02777 272562007893 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 272562007894 dimerization interface [polypeptide binding]; other site 272562007895 putative DNA binding site [nucleotide binding]; other site 272562007896 Transcriptional regulators [Transcription]; Region: Lrp; COG1522 272562007897 putative Zn2+ binding site [ion binding]; other site 272562007898 Uncharacterized conserved protein [Function unknown]; Region: COG5015 272562007899 Arabinogalactan endo-1,4-beta-galactosidase [Carbohydrate transport and metabolism]; Region: COG3867 272562007900 Acetyltransferases, including N-acetylases of ribosomal proteins [Translation, ribosomal structure and biogenesis]; Region: RimL; COG1670 272562007901 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 272562007902 Coenzyme A binding pocket [chemical binding]; other site 272562007903 Phosphotransferase enzyme family; Region: APH; pfam01636 272562007904 Aminoglycoside 3'-phosphotransferase (APH) and Choline Kinase (ChoK) family. The APH/ChoK family is part of a larger superfamily that includes the catalytic domains of other kinases, such as the typical serine/threonine/tyrosine protein kinases (PKs)...; Region: APH_ChoK_like; cd05120 272562007905 active site 272562007906 substrate binding site [chemical binding]; other site 272562007907 ATP binding site [chemical binding]; other site 272562007908 Aminoglycoside 3'-phosphotransferase (APH) and Choline Kinase (ChoK) family. The APH/ChoK family is part of a larger superfamily that includes the catalytic domains of other kinases, such as the typical serine/threonine/tyrosine protein kinases (PKs)...; Region: APH_ChoK_like; cl17270 272562007909 Methyltransferase domain; Region: Methyltransf_31; pfam13847 272562007910 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 272562007911 S-adenosylmethionine binding site [chemical binding]; other site 272562007912 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 272562007913 S-adenosylmethionine binding site [chemical binding]; other site 272562007914 Rubrerythrin [Energy production and conversion]; Region: COG1592 272562007915 Rubrerythrin, ferritin-like diiron-binding domain; Region: Rubrerythrin; cd01041 272562007916 binuclear metal center [ion binding]; other site 272562007917 Rubredoxin, Small Modular nonheme iron binding domain containing a [Fe(SCys)4] center, present in rubrerythrin and nigerythrin and detected either N- or C-terminal to such proteins as flavin reductase, NAD(P)H-nitrite reductase, and...; Region: rubredoxin_SM; cd00729 272562007918 iron binding site [ion binding]; other site 272562007919 6-pyruvoyl tetrahydropterin synthase-related domain; Region: 6_pyr_pter_rel; TIGR03112 272562007920 active site 272562007921 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 272562007922 putative glycosyltransferase, exosortase G-associated; Region: glyc2_xrt_Gpos1; TIGR03111 272562007923 CESA_like is the cellulose synthase superfamily; Region: CESA_like; cd06423 272562007924 DXD motif; other site 272562007925 exosortase family protein XrtG; Region: exosort_Gpos; TIGR03110 272562007926 Domon-like ligand-binding domains; Region: DOMON_like; cl14783 272562007927 Firmicu-CTERM domain; Region: Firmicu_CTERM; TIGR04145 272562007928 6-pyruvoyl tetrahydropterin synthase-related domain; Region: 6_pyr_pter_rel; TIGR03112 272562007929 Predicted integral membrane protein [Function unknown]; Region: COG5617 272562007930 Predicted membrane protein [Function unknown]; Region: COG1511 272562007931 YhgE/Pip N-terminal domain; Region: pip_yhgE_Nterm; cl19580 272562007932 Apolipophorin-III and similar insect proteins; Region: ApoLp-III_like; cl19113 272562007933 YhgE/Pip C-terminal domain; Region: pip_yhgE_Cterm; TIGR03062 272562007934 Predicted membrane protein [Function unknown]; Region: COG1511 272562007935 YhgE/Pip N-terminal domain; Region: pip_yhgE_Nterm; cl19580 272562007936 YhgE/Pip C-terminal domain; Region: pip_yhgE_Cterm; TIGR03062 272562007937 Bacterial surface proteins containing Ig-like domains [Cell motility and secretion]; Region: COG5492 272562007938 Clostridial hydrophobic, with a conserved W residue, domain; Region: ChW; smart00728 272562007939 Clostridial hydrophobic, with a conserved W residue, domain; Region: ChW; smart00728 272562007940 Clostridial hydrophobic, with a conserved W residue, domain; Region: ChW; smart00728 272562007941 Clostridial hydrophobic, with a conserved W residue, domain; Region: ChW; smart00728 272562007942 Clostridial hydrophobic, with a conserved W residue, domain; Region: ChW; smart00728 272562007943 Clostridial hydrophobic, with a conserved W residue, domain; Region: ChW; smart00728 272562007944 6-pyruvoyl tetrahydropterin synthase-related domain; Region: 6_pyr_pter_rel; TIGR03112 272562007945 Class III nucleotidyl cyclases; Region: Nucleotidyl_cyc_III; cl11967 272562007946 metal binding site [ion binding]; metal-binding site 272562007947 nucleotidyl binding site; other site 272562007948 DPM_DPG-synthase_like is a member of the Glycosyltransferase 2 superfamily; Region: DPM_DPG-synthase_like; cd04179 272562007949 Ligand binding site; other site 272562007950 Putative Catalytic site; other site 272562007951 DXD motif; other site 272562007952 putative glycosyltransferase, exosortase G-associated; Region: glyc2_xrt_Gpos1; TIGR03111 272562007953 CESA_like is the cellulose synthase superfamily; Region: CESA_like; cd06423 272562007954 DXD motif; other site 272562007955 Transmembrane exosortase (Exosortase_EpsH); Region: Exosortase_EpsH; cl15694 272562007956 Domon-like ligand-binding domains; Region: DOMON_like; cl14783 272562007957 putative ligand binding site [chemical binding]; other site 272562007958 Firmicu-CTERM domain; Region: Firmicu_CTERM; TIGR04145 272562007959 6-pyruvoyl tetrahydropterin synthase-related domain; Region: 6_pyr_pter_rel; TIGR03112 272562007960 Predicted integral membrane protein [Function unknown]; Region: COG5617 272562007961 Lysine efflux permease [General function prediction only]; Region: COG1279 272562007962 putative aminophosphonate oxidoreductase; Region: Phn_aa_oxid; TIGR03329 272562007963 Glycine/D-amino acid oxidases (deaminating) [Amino acid transport and metabolism]; Region: DadA; COG0665 272562007964 Rieske Fe-S protein [Energy production and conversion]; Region: QcrA; COG0723 272562007965 Rieske domain; a [2Fe-2S] cluster binding domain commonly found in Rieske non-heme iron oxygenase (RO) systems such as naphthalene and biphenyl dioxygenases, as well as in plant/cyanobacterial chloroplast b6f and mitochondrial cytochrome bc(1) complexes; Region: Rieske; cl00938 272562007966 iron-sulfur cluster [ion binding]; other site 272562007967 [2Fe-2S] cluster binding site [ion binding]; other site 272562007968 Protein of unknown function (DUF3892); Region: DUF3892; pfam13031 272562007969 S-adenosylmethionine decarboxylase; Provisional; Region: PRK05462 272562007970 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 272562007971 S-adenosylmethionine binding site [chemical binding]; other site 272562007972 Protein of unknown function (DUF1113); Region: DUF1113; cl19877 272562007973 probable dihydroxyacetone kinase regulator; Region: DHAK_reg; TIGR02366 272562007974 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 272562007975 hypothetical protein; Provisional; Region: PRK09273 272562007976 Ribose 5-phosphate isomerase RpiB [Carbohydrate transport and metabolism]; Region: RpiB; COG0698 272562007977 Ribose-5-phosphate isomerase; Region: DUF3666; pfam12408 272562007978 gluconate 5-dehydrogenase; Provisional; Region: PRK07097 272562007979 gluconate 5-dehydrogenase (Ga5DH)-like, classical (c) SDRs; Region: Ga5DH-like_SDR_c; cd05347 272562007980 NADP binding site [chemical binding]; other site 272562007981 homodimer interface [polypeptide binding]; other site 272562007982 active site 272562007983 AraC-like ligand binding domain; Region: AraC_binding; pfam02311 272562007984 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 272562007985 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 272562007986 Cytidine deaminase [Nucleotide transport and metabolism]; Region: Cdd; COG0295 272562007987 Cytidine deaminase zinc-binding domain. These enzymes are Zn dependent. The zinc ion in the active site plays a central role in the proposed catalytic mechanism, activating a water molecule to form a hydroxide ion that performs a nucleophilic attack on...; Region: cytidine_deaminase; cd01283 272562007988 active site 272562007989 catalytic motif [active] 272562007990 Zn binding site [ion binding]; other site 272562007991 L-fucose isomerase and related proteins [Carbohydrate transport and metabolism]; Region: FucI; COG2407 272562007992 L-fucose isomerase (FucIase) and L-arabinose isomerase (AI) family; composed of FucIase, AI and similar proteins. FucIase converts L-fucose, an aldohexose, to its ketose form, which prepares it for aldol cleavage (similar to the isomerization of glucose...; Region: L-fuc_L-ara-isomerases; cd00578 272562007993 hexamer (dimer of trimers) interface [polypeptide binding]; other site 272562007994 trimer interface [polypeptide binding]; other site 272562007995 substrate binding site [chemical binding]; other site 272562007996 Mn binding site [ion binding]; other site 272562007997 Escherichia coli xylulokinase-like D-xylulose kinases; a subgroup of the FGGY family of carbohydrate kinases; Region: FGGY_D-XK_EcXK-like; cd07808 272562007998 N- and C-terminal domain interface [polypeptide binding]; other site 272562007999 D-xylulose kinase; Region: XylB; TIGR01312 272562008000 active site 272562008001 MgATP binding site [chemical binding]; other site 272562008002 catalytic site [active] 272562008003 metal binding site [ion binding]; metal-binding site 272562008004 xylulose binding site [chemical binding]; other site 272562008005 homodimer interface [polypeptide binding]; other site 272562008006 ROK family protein (putative glucokinase); Region: ROK_glcA_fam; TIGR00744 272562008007 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cd00012 272562008008 nucleotide binding site [chemical binding]; other site 272562008009 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cl17037 272562008010 beta-phosphoglucomutase; Region: bPGM; TIGR01990 272562008011 haloacid dehalogenase-like hydrolase; Region: HAD; cl19137 272562008012 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 272562008013 Ferritin-like superfamily of diiron-containing four-helix-bundle proteins; Region: Ferritin_like; cd00657 272562008014 dinuclear metal binding motif [ion binding]; other site 272562008015 manganese transport transcriptional regulator; Provisional; Region: PRK03902 272562008016 Iron dependent repressor, N-terminal DNA binding domain; Region: Fe_dep_repress; pfam01325 272562008017 Iron dependent repressor, metal binding and dimerization domain; Region: Fe_dep_repr_C; pfam02742 272562008018 Cache domain; Region: Cache_1; pfam02743 272562008019 Methyl-accepting chemotaxis protein [Cell motility and secretion / Signal transduction mechanisms]; Region: Tar; COG0840 272562008020 HAMP domain; Region: HAMP; pfam00672 272562008021 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cl19050 272562008022 dimer interface [polypeptide binding]; other site 272562008023 putative CheW interface [polypeptide binding]; other site 272562008024 Domain of Unknown Function with PDB structure (DUF3862); Region: DUF3862; pfam12978 272562008025 SGNH_hydrolase, or GDSL_hydrolase, is a diverse family of lipases and esterases. The tertiary fold of the enzyme is substantially different from that of the alpha/beta hydrolase family and unique among all known hydrolases; its active site closely...; Region: SGNH_hydrolase; cd00229 272562008026 active site 272562008027 catalytic triad [active] 272562008028 oxyanion hole [active] 272562008029 c-di-GMP phosphodiesterase class II (HD-GYP domain) [Signal transduction mechanisms]; Region: COG2206 272562008030 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 272562008031 Zn2+ binding site [ion binding]; other site 272562008032 Mg2+ binding site [ion binding]; other site 272562008033 Lyc muramidase is an autolytic lysozyme (autolysin) from Clostridium acetobutylicum encoded by the lyc gene. Lyc has a glycosyl hydrolase family 25 (GH25) catalytic domain. Endo-N-acetylmuramidases are lysozymes (also referred to as peptidoglycan...; Region: GH25_Lyc-like; cd06525 272562008034 Glycosyl hydrolases family 25; Region: Glyco_hydro_25; pfam01183 272562008035 active site 272562008036 Putative peptidoglycan-binding domain-containing protein [Cell envelope biogenesis, outer membrane]; Region: COG3409 272562008037 Putative peptidoglycan binding domain; Region: PG_binding_1; pfam01471 272562008038 Putative peptidoglycan binding domain; Region: PG_binding_1; pfam01471 272562008039 Predicted hydrolase (metallo-beta-lactamase superfamily) [General function prediction only]; Region: ComEC; COG2333 272562008040 Metallo-beta-lactamase superfamily; Region: Lactamase_B; pfam00753 272562008041 Protein Kinases, catalytic domain; Region: PKc_like; cl09925 272562008042 ATP binding site [chemical binding]; other site 272562008043 Serine/threonine protein kinase [General function prediction only / Signal transduction mechanisms / Transcription / DNA replication, recombination, and repair]; Region: SPS1; COG0515 272562008044 AAA ATPase domain; Region: AAA_16; pfam13191 272562008045 Predicted ATPase [General function prediction only]; Region: COG3899 272562008046 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 272562008047 metal binding site [ion binding]; metal-binding site 272562008048 active site 272562008049 I-site; other site 272562008050 GAF domain; Region: GAF_3; pfam13492 272562008051 diaminopimelate epimerase; Provisional; Region: dapF; PRK00450 272562008052 Diaminopimelate epimerase; Region: DAP_epimerase; pfam01678 272562008053 Diaminopimelate epimerase; Region: DAP_epimerase; cl19724 272562008054 Predicted hydrolase (metallo-beta-lactamase superfamily) [General function prediction only]; Region: ComEC; COG2333 272562008055 3-ketoacyl-(acyl-carrier-protein) reductase; Provisional; Region: fabG; PRK05565 272562008056 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 272562008057 NAD(P) binding site [chemical binding]; other site 272562008058 active site 272562008059 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 272562008060 S-adenosylmethionine binding site [chemical binding]; other site 272562008061 Uncharacterized homologs of Site-2 protease (S2P), zinc metalloproteases (MEROPS family M50) which cleave transmembrane domains of substrate proteins, regulating intramembrane proteolysis (RIP) of diverse signal transduction mechanisms. Members of the...; Region: S2P-M50_like_1; cd06158 272562008062 Peptidase family M50; Region: Peptidase_M50; pfam02163 272562008063 active site 272562008064 putative substrate binding region [chemical binding]; other site 272562008065 Exopolysaccharide biosynthesis protein related to N-acetylglucosamine-1-phosphodiester alpha-N-acetylglucosaminidase [Carbohydrate transport and metabolism]; Region: EpsL; COG4632 272562008066 Predicted periplasmic protein (DUF2233); Region: DUF2233; pfam09992 272562008067 Uncharacterized protein conserved in bacteria [Function unknown]; Region: ErfK; COG1376 272562008068 L,D-transpeptidase catalytic domain; Region: YkuD; pfam03734 272562008069 Polysaccharide pyruvyl transferase; Region: PS_pyruv_trans; cl09156 272562008070 Exopolysaccharide biosynthesis protein related to N-acetylglucosamine-1-phosphodiester alpha-N-acetylglucosaminidase [Carbohydrate transport and metabolism]; Region: EpsL; COG4632 272562008071 Predicted periplasmic protein (DUF2233); Region: DUF2233; pfam09992 272562008072 Ferric uptake regulator(Fur) and related metalloregulatory proteins; typically iron-dependent, DNA-binding repressors and activators; Region: Fur_like; cd07153 272562008073 metal binding site 2 [ion binding]; metal-binding site 272562008074 putative DNA binding helix; other site 272562008075 metal binding site 1 [ion binding]; metal-binding site 272562008076 dimer interface [polypeptide binding]; other site 272562008077 structural Zn2+ binding site [ion binding]; other site 272562008078 Predicted GTPase [General function prediction only]; Region: COG0218 272562008079 YihA (EngB) GTPase family; Region: YihA_EngB; cd01876 272562008080 G1 box; other site 272562008081 GTP/Mg2+ binding site [chemical binding]; other site 272562008082 Switch I region; other site 272562008083 G2 box; other site 272562008084 G3 box; other site 272562008085 Switch II region; other site 272562008086 G4 box; other site 272562008087 G5 box; other site 272562008088 ATP-dependent Lon protease, bacterial type [Posttranslational modification, protein turnover, chaperones]; Region: Lon; COG0466 272562008089 ATP-dependent protease La (LON) domain; Region: LON; pfam02190 272562008090 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 272562008091 Walker A motif; other site 272562008092 ATP binding site [chemical binding]; other site 272562008093 Walker B motif; other site 272562008094 arginine finger; other site 272562008095 Lon protease (S16) C-terminal proteolytic domain; Region: Lon_C; pfam05362 272562008096 ATP-dependent protease LonB; Region: spore_lonB; TIGR02902 272562008097 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 272562008098 Walker A motif; other site 272562008099 ATP binding site [chemical binding]; other site 272562008100 Walker B motif; other site 272562008101 arginine finger; other site 272562008102 Lon protease (S16) C-terminal proteolytic domain; Region: Lon_C; pfam05362 272562008103 ATP-dependent protease ATP-binding subunit ClpX; Provisional; Region: clpX; PRK05342 272562008104 ClpX C4-type zinc finger; Region: zf-C4_ClpX; pfam06689 272562008105 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 272562008106 Walker A motif; other site 272562008107 ATP binding site [chemical binding]; other site 272562008108 Walker B motif; other site 272562008109 C-terminal, D2-small domain, of ClpB protein; Region: ClpB_D2-small; smart01086 272562008110 Caseinolytic protease (ClpP) is an ATP-dependent, highly conserved serine protease; Region: S14_ClpP_2; cd07017 272562008111 oligomer interface [polypeptide binding]; other site 272562008112 active site residues [active] 272562008113 trigger factor; Provisional; Region: tig; PRK01490 272562008114 Bacterial trigger factor protein (TF); Region: Trigger_N; pfam05697 272562008115 FKBP-type peptidyl-prolyl cis-trans isomerase; Region: FKBP_C; pfam00254 272562008116 Bacterial trigger factor protein (TF) C-terminus; Region: Trigger_C; pfam05698 272562008117 Sugar phosphate isomerases/epimerases [Carbohydrate transport and metabolism]; Region: IolE; COG1082 272562008118 Xylose isomerase-like TIM barrel; Region: AP_endonuc_2; pfam01261 272562008119 carbamoyl phosphate synthase large subunit; Reviewed; Region: carB; PRK05294 272562008120 Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289 272562008121 Carbamoyl-phosphate synthase L chain, ATP binding domain; Region: CPSase_L_D2; pfam02786 272562008122 Carbamoyl-phosphate synthetase large chain, oligomerization domain; Region: CPSase_L_D3; pfam02787 272562008123 Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289 272562008124 ATP-grasp domain; Region: ATP-grasp_4; cl17255 272562008125 Methylglyoxal synthase-like domain from type II glutamine-dependent carbamoyl phosphate synthetase (CSP). CSP, a CarA and CarB heterodimer, catalyzes the production of carbamoyl phosphate which is subsequently employed in the metabolic pathways...; Region: MGS_CPS_II; cd01424 272562008126 IMP binding site; other site 272562008127 dimer interface [polypeptide binding]; other site 272562008128 interdomain contacts; other site 272562008129 partial ornithine binding site; other site 272562008130 carbamoyl phosphate synthase small subunit; Reviewed; Region: PRK12564 272562008131 Carbamoyl-phosphate synthase small chain, CPSase domain; Region: CPSase_sm_chain; pfam00988 272562008132 Small chain of the glutamine-dependent form of carbamoyl phosphate synthase, CPSase II; Region: GATase1_CPSase; cd01744 272562008133 catalytic site [active] 272562008134 subunit interface [polypeptide binding]; other site 272562008135 signal peptidase I, bacterial type; Region: sigpep_I_bact; TIGR02227 272562008136 The S26 Type I signal peptidase (SPase; LepB; leader peptidase B; leader peptidase I; EC 3.4.21.89) family members are essential membrane-bound serine proteases that function to cleave the amino-terminal signal peptide extension from proteins that are...; Region: S26_SPase_I; cd06530 272562008137 Catalytic site [active] 272562008138 The S24, S26 LexA/signal peptidase superfamily contains LexA-related and type I signal peptidase families. The S24 LexA protein domains include: the lambda repressor CI/C2 family and related bacterial prophage repressor proteins; LexA (EC 3.4.21.88), the...; Region: Peptidase_S24_S26; cl10465 272562008139 Predicted integral membrane protein [Function unknown]; Region: COG5523 272562008140 Predicted integral membrane protein [Function unknown]; Region: COG5523 272562008141 Dihydroorotate dehydrogenase (DHOD) class 1B FMN-binding domain. DHOD catalyzes the oxidation of (S)-dihydroorotate to orotate. This is the fourth step and the only redox reaction in the de novo biosynthesis of UMP, the precursor of all pyrimidine...; Region: DHOD_1B_like; cd04740 272562008142 heterodimer interface [polypeptide binding]; other site 272562008143 active site 272562008144 FMN binding site [chemical binding]; other site 272562008145 homodimer interface [polypeptide binding]; other site 272562008146 substrate binding site [chemical binding]; other site 272562008147 dihydroorotate dehydrogenase electron transfer subunit; Reviewed; Region: PRK00054 272562008148 FAD/NAD binding domain in the electron transfer subunit of dihydroorotate dehydrogenase. Dihydroorotate dehydrogenases (DHODs) catalyze the only redox reaction in pyrimidine de novo biosynthesis. They catalyze the oxidation of (S)-dihydroorotate to...; Region: DHOD_e_trans; cd06218 272562008149 FAD binding pocket [chemical binding]; other site 272562008150 FAD binding motif [chemical binding]; other site 272562008151 phosphate binding motif [ion binding]; other site 272562008152 beta-alpha-beta structure motif; other site 272562008153 NAD binding pocket [chemical binding]; other site 272562008154 Iron coordination center [ion binding]; other site 272562008155 Orotidine 5'-phosphate decarboxylase (ODCase) is a dimeric enzyme that decarboxylates orotidine 5'-monophosphate (OMP) to form uridine 5'-phosphate (UMP), an essential step in the pyrimidine biosynthetic pathway. In mammals, UMP synthase...; Region: OMP_decarboxylase_like; cd04725 272562008156 active site 272562008157 dimer interface [polypeptide binding]; other site 272562008158 Aspartate carbamoyltransferase, regulatory subunit [Nucleotide transport and metabolism]; Region: PyrI; COG1781 272562008159 Aspartate carbamoyltransferase regulatory chain, allosteric domain; Region: PyrI; pfam01948 272562008160 Aspartate carbamoyltransferase regulatory chain, metal binding domain; Region: PyrI_C; pfam02748 272562008161 Aspartate carbamoyltransferase, catalytic chain [Nucleotide transport and metabolism]; Region: PyrB; COG0540 272562008162 Aspartate/ornithine carbamoyltransferase, carbamoyl-P binding domain; Region: OTCace_N; pfam02729 272562008163 Aspartate/ornithine carbamoyltransferase, Asp/Orn binding domain; Region: OTCace; pfam00185 272562008164 Uncharacterized membrane-associated protein [Function unknown]; Region: DedA; COG0586 272562008165 Pyridoxamine 5'-phosphate oxidase; Region: Pyridox_oxidase; pfam01243 272562008166 Flavodoxin domain; Region: Flavodoxin_5; cl17428 272562008167 4Fe-4S dicluster domain; Region: Fer4_10; pfam13237 272562008168 The HCP family of iron-sulfur proteins includes hybrid cluster protein (HCP), acetyl-CoA synthase (ACS), and carbon monoxide dehydrogenase (CODH), all of which contain [Fe4-S4] metal clusters at their active sites. These proteins have a conserved...; Region: HCP_like; cl19102 272562008169 Uncharacterized protein related to glutamine synthetase [General function prediction only]; Region: COG3968 272562008170 Glutamine synthetase type III N terminal; Region: GSIII_N; pfam12437 272562008171 Glutamine synthetase, catalytic domain; Region: Gln-synt_C; pfam00120 272562008172 Chemotaxis phosphatase, CheZ; Region: CheZ; cl01219 272562008173 Putative stress-responsive transcriptional regulator [Transcription / Signal transduction mechanisms]; Region: PspC; COG1983 272562008174 pyruvate carboxylase; Reviewed; Region: PRK12999 272562008175 Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289 272562008176 ATP-grasp domain; Region: ATP-grasp_4; cl17255 272562008177 Biotin carboxylase C-terminal domain; Region: Biotin_carb_C; smart00878 272562008178 Pyruvate carboxylase and Transcarboxylase 5S, carboxyltransferase domain; Region: DRE_TIM_PC_TC_5S; cd07937 272562008179 active site 272562008180 catalytic residues [active] 272562008181 metal binding site [ion binding]; metal-binding site 272562008182 homodimer binding site [polypeptide binding]; other site 272562008183 Conserved carboxylase domain; Region: PYC_OADA; pfam02436 272562008184 The biotinyl-domain or biotin carboxyl carrier protein (BCCP) domain is present in all biotin-dependent enzymes, such as acetyl-CoA carboxylase, pyruvate carboxylase, propionyl-CoA carboxylase, methylcrotonyl-CoA carboxylase, geranyl-CoA carboxylase; Region: biotinyl_domain; cd06850 272562008185 carboxyltransferase (CT) interaction site; other site 272562008186 biotinylation site [posttranslational modification]; other site 272562008187 Cell division protein [Cell division and chromosome partitioning]; Region: FtsX; COG2177 272562008188 cell division ABC transporter subunit FtsX; Provisional; Region: ftsX; PRK11026 272562008189 Cell wall-associated hydrolases (invasion-associated proteins) [Cell envelope biogenesis, outer membrane]; Region: Spr; COG0791 272562008190 Orthopoxvirus protein of unknown function (DUF830); Region: DUF830; cl13998 272562008191 NlpC/P60 family; Region: NLPC_P60; pfam00877 272562008192 Escherichia coli YfcE and related proteins, metallophosphatase domain; Region: MPP_YfcE; cd00841 272562008193 active site 272562008194 metal binding site [ion binding]; metal-binding site 272562008195 homotetramer interface [polypeptide binding]; other site 272562008196 NTPase/HAM1. This family consists of the HAM1 protein and pyrophosphate-releasing xanthosine/ inosine triphosphatase. HAM1 protects the cell against mutagenesis by the base analog 6-N-hydroxylaminopurine (HAP) in E. Coli and S. cerevisiae. A...; Region: HAM1; cd00515 272562008197 active site 272562008198 dimerization interface [polypeptide binding]; other site 272562008199 metal ion transporter CorA-like divalent cation transporter superfamily; Region: MIT_CorA-like; cl00459 272562008200 oligomer interface [polypeptide binding]; other site 272562008201 ABC-type oligopeptide transport system, periplasmic component [Amino acid transport and metabolism]; Region: OppA; COG4166 272562008202 The substrate-binding component of an ABC-type oligopetide import system contains the type 2 periplasmic binding fold; Region: PBP2_OppA; cd08504 272562008203 peptide binding site [polypeptide binding]; other site 272562008204 aspartyl/glutamyl-tRNA amidotransferase subunit B; Validated; Region: gatB; PRK05477 272562008205 GatB/GatE catalytic domain; Region: GatB_N; pfam02934 272562008206 GatB domain; Region: GatB_Yqey; pfam02637 272562008207 aspartyl/glutamyl-tRNA amidotransferase subunit A; Reviewed; Region: gatA; PRK00012 272562008208 aspartyl/glutamyl-tRNA(Asn/Gln) amidotransferase, C subunit; Region: gatC; TIGR00135 272562008209 NAD-dependent DNA ligase LigA; Validated; Region: ligA; PRK07956 272562008210 NAD+ dependent DNA ligase adenylation domain. DNA ligases catalyze the crucial step of joining the breaks in duplex DNA during DNA replication, repair and recombination, utilizing either ATP or NAD(+) as a cofactor, but using the same basic reaction...; Region: LIGANc; cd00114 272562008211 nucleotide binding pocket [chemical binding]; other site 272562008212 K-X-D-G motif; other site 272562008213 catalytic site [active] 272562008214 NAD-dependent DNA ligase OB-fold domain; Region: DNA_ligase_OB; pfam03120 272562008215 Helix-hairpin-helix domain; Region: HHH_5; pfam14520 272562008216 Helix-hairpin-helix motif; Region: HHH_2; pfam12826 272562008217 Breast Cancer Suppressor Protein (BRCA1), carboxy-terminal domain. The BRCT domain is found within many DNA damage repair and cell cycle checkpoint proteins. The unique diversity of this domain superfamily allows BRCT modules to interact forming homo...; Region: BRCT; cd00027 272562008218 Dimer interface [polypeptide binding]; other site 272562008219 BRCT sequence motif; other site 272562008220 ATP-dependent DNA helicase PcrA; Region: pcrA; TIGR01073 272562008221 Part of AAA domain; Region: AAA_19; pfam13245 272562008222 UvrD-like helicase C-terminal domain; Region: UvrD_C_2; pfam13538 272562008223 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4496 272562008224 16S rRNA uridine-516 pseudouridylate synthase and related pseudouridylate synthases [Translation, ribosomal structure and biogenesis]; Region: RsuA; COG1187 272562008225 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 272562008226 RNA binding surface [nucleotide binding]; other site 272562008227 Pseudouridine synthase, Escherichia coli RsuA like; Region: PseudoU_synth_RsuA; cd02553 272562008228 active site 272562008229 uracil binding [chemical binding]; other site 272562008230 Soluble lytic murein transglycosylase and related regulatory proteins (some contain LysM/invasin domains) [Cell envelope biogenesis, outer membrane]; Region: MltE; COG0741 272562008231 Lytic Transglycosylase (LT) and Goose Egg White Lysozyme (GEWL) domain. Members include the soluble and insoluble membrane-bound LTs in bacteria, the LTs in bacteriophage lambda, as well as, the eukaryotic "goose-type" lysozymes (GEWL). LTs...; Region: LT_GEWL; cd00254 272562008232 N-acetyl-D-glucosamine binding site [chemical binding]; other site 272562008233 catalytic residue [active] 272562008234 triple tyrosine motif-containing protein; Provisional; Region: PRK14081 272562008235 Y_Y_Y domain; Region: Y_Y_Y; pfam07495 272562008236 Y_Y_Y domain; Region: Y_Y_Y; pfam07495 272562008237 Y_Y_Y domain; Region: Y_Y_Y; pfam07495 272562008238 Y_Y_Y domain; Region: Y_Y_Y; pfam07495 272562008239 Y_Y_Y domain; Region: Y_Y_Y; pfam07495 272562008240 Y_Y_Y domain; Region: Y_Y_Y; pfam07495 272562008241 pullulanase, type I; Region: pulA_typeI; TIGR02104 272562008242 Early set domain associated with the catalytic domain of pullulanase (also called dextrinase and alpha-dextrin endo-1,6-alpha glucosidase); Region: E_set_Pullulanase; cd02860 272562008243 Alpha amylase catalytic domain found in Pullulanase (also called dextrinase; alpha-dextrin endo-1,6-alpha glucosidase), limit dextrinase, and related proteins; Region: AmyAc_Pullulanase_LD-like; cd11341 272562008244 Ca binding site [ion binding]; other site 272562008245 active site 272562008246 catalytic site [active] 272562008247 glucose-6-phosphate isomerase; Provisional; Region: pgi; PRK14097 272562008248 Phosphoglucose isomerase (PGI) contains two SIS (Sugar ISomerase) domains. This classification is based on the alignment of the first SIS domain. PGI is a multifunctional enzyme which as an intracellular dimer catalyzes the reversible isomerization of...; Region: SIS_PGI_1; cd05015 272562008249 active site 272562008250 dimer interface [polypeptide binding]; other site 272562008251 Phosphoglucose isomerase (PGI) contains two SIS (Sugar ISomerase) domains. This classification is based on the alignment of the second SIS domain. PGI is a multifunctional enzyme which as an intracellular dimer catalyzes the reversible isomerization of...; Region: SIS_PGI_2; cd05016 272562008252 dimer interface [polypeptide binding]; other site 272562008253 active site 272562008254 Domain of unknown function (DUF4325); Region: DUF4325; pfam14213 272562008255 Coat F domain; Region: Coat_F; pfam07875 272562008256 2-keto-3-deoxygluconate kinase (KdgK) phosphorylates 2-keto-3-deoxygluconate (KDG) to form 2-keto-3-deoxy-6-phosphogluconate (KDGP). KDG is the common intermediate product, that allows organisms to channel D-glucuronate and/or D-galacturinate into the...; Region: KdgK; cd01166 272562008257 substrate binding site [chemical binding]; other site 272562008258 ATP binding site [chemical binding]; other site 272562008259 maltose phosphorylase; Provisional; Region: PRK13807 272562008260 Glycosyl hydrolase family 65, N-terminal domain; Region: Glyco_hydro_65N; pfam03636 272562008261 Glycosyl hydrolase family 65 central catalytic domain; Region: Glyco_hydro_65m; pfam03632 272562008262 Glycosyl hydrolase family 65, C-terminal domain; Region: Glyco_hydro_65C; pfam03633 272562008263 Glycosidases [Carbohydrate transport and metabolism]; Region: AmyA; COG0366 272562008264 Alpha amylase catalytic domain found in eukaryotic and bacterial cyclomaltodextrinases and related proteins; Region: AmyAc_euk_bac_CMD_like; cd11353 272562008265 active site 272562008266 catalytic site [active] 272562008267 ATP-dependent DNA helicase RecQ; Region: recQ; TIGR01389 272562008268 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 272562008269 ATP binding site [chemical binding]; other site 272562008270 putative Mg++ binding site [ion binding]; other site 272562008271 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 272562008272 nucleotide binding region [chemical binding]; other site 272562008273 ATP-binding site [chemical binding]; other site 272562008274 This DNA-binding domain is found in the RecQ helicase among others and has a helix-turn-helix structure; Region: RQC; smart00956 272562008275 HRDC domain; Region: HRDC; pfam00570 272562008276 Helix-turn-helix domain; Region: HTH_40; pfam14493 272562008277 Putative lysophospholipase; Region: Hydrolase_4; cl19140 272562008278 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 272562008279 Prolyl oligopeptidase family; Region: Peptidase_S9; cl19144 272562008280 Putative amidase domain; Region: Amidase_6; pfam12671 272562008281 Transcriptional regulator [Transcription]; Region: LysR; COG0583 272562008282 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 272562008283 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cd05466 272562008284 dimerization interface [polypeptide binding]; other site 272562008285 Lactate dehydrogenase and related dehydrogenases [Energy production and conversion / Coenzyme metabolism / General function prediction only]; Region: LdhA; COG1052 272562008286 Putative Lactate dehydrogenase and (R)-2-Hydroxyglutarate Dehydrogenase-like proteins, NAD-binding and catalytic domains; Region: HGDH_LDH_like; cd12185 272562008287 putative ligand binding site [chemical binding]; other site 272562008288 putative NAD binding site [chemical binding]; other site 272562008289 catalytic site [active] 272562008290 galactoside O-acetyltransferase; Reviewed; Region: lacA; PRK09527 272562008291 Maltose O-acetyltransferase (MAT) and Galactoside O-acetyltransferase (GAT): MAT and GAT catalyze the CoA-dependent acetylation of the 6-hydroxyl group of their respective sugar substrates. MAT acetylates maltose and glucose exclusively at the C6...; Region: LbH_MAT_GAT; cd03357 272562008292 active site 272562008293 substrate binding site [chemical binding]; other site 272562008294 trimer interface [polypeptide binding]; other site 272562008295 CoA binding site [chemical binding]; other site 272562008296 Bacterial SH3 domain; Region: SH3_3; pfam08239 272562008297 Helix-turn-helix domain; Region: HTH_17; pfam12728 272562008298 Putative peptidoglycan-binding domain-containing protein [Cell envelope biogenesis, outer membrane]; Region: COG3409 272562008299 Putative peptidoglycan binding domain; Region: PG_binding_1; pfam01471 272562008300 GMP synthase; Reviewed; Region: guaA; PRK00074 272562008301 Type 1 glutamine amidotransferase (GATase1) domain found in GMP synthetase; Region: GATase1_GMP_Synthase; cd01742 272562008302 AMP/PPi binding site [chemical binding]; other site 272562008303 candidate oxyanion hole; other site 272562008304 catalytic triad [active] 272562008305 potential glutamine specificity residues [chemical binding]; other site 272562008306 The C-terminal domain of GMP synthetase. It contains two subdomains; the ATP pyrophosphatase domain which closes to the N-termial and the dimerization domain at C-terminal end. The ATP-PPase is a twisted, five-stranded parallel beta-sheet sandwiched...; Region: GMP_synthase_C; cd01997 272562008307 ATP Binding subdomain [chemical binding]; other site 272562008308 Ligand Binding sites [chemical binding]; other site 272562008309 Dimerization subdomain; other site 272562008310 inosine 5'-monophosphate dehydrogenase; Reviewed; Region: PRK05567 272562008311 IMPDH: The catalytic domain of the inosine monophosphate dehydrogenase. IMPDH catalyzes the NAD-dependent oxidation of inosine 5'-monophosphate (IMP) to xanthosine 5' monophosphate (XMP). It is a rate-limiting step in the de novo synthesis of...; Region: IMPDH; cd00381 272562008312 active site 272562008313 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains in the inosine 5' monophosphate dehydrogenase (IMPDH) protein. IMPDH is an essential enzyme that catalyzes the first step unique to GTP synthesis, playing a...; Region: CBS_pair_IMPDH; cd04601 272562008314 EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2). The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948 272562008315 The CBS domain, named after human CBS, is a small domain originally identified in cystathionine beta-synthase and is subsequently found in a wide range of different proteins. CBS domains usually occur in tandem repeats. They associate to form a so-called...; Region: CBS_pair; cl15354 272562008316 FOG: CBS domain [General function prediction only]; Region: COG0517 272562008317 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 272562008318 metal binding site [ion binding]; metal-binding site 272562008319 active site 272562008320 I-site; other site 272562008321 chaperonin GroEL; Reviewed; Region: groEL; PRK12850 272562008322 GroEL_like type I chaperonin. Chaperonins are involved in productive folding of proteins. They share a common general morphology, a double toroid of 2 stacked rings, each composed of 7-9 subunits. The symmetry of type I is seven-fold and they are found...; Region: GroEL; cd03344 272562008323 ring oligomerisation interface [polypeptide binding]; other site 272562008324 ATP/Mg binding site [chemical binding]; other site 272562008325 stacking interactions; other site 272562008326 hinge regions; other site 272562008327 Chaperonin 10 Kd subunit (cpn10 or GroES); Cpn10 cooperates with chaperonin 60 (cpn60 or GroEL), an ATPase, to assist the folding and assembly of proteins and is found in eubacterial cytosol, as well as in the matrix of mitochondria and chloroplasts. It...; Region: cpn10; cd00320 272562008328 oligomerisation interface [polypeptide binding]; other site 272562008329 mobile loop; other site 272562008330 roof hairpin; other site 272562008331 Predicted membrane protein [Function unknown]; Region: COG4478 272562008332 Uncharacterized conserved protein [Function unknown]; Region: COG0398 272562008333 3-methyladenine DNA glycosylase/8-oxoguanine DNA glycosylase [DNA replication, recombination, and repair]; Region: AlkA; COG0122 272562008334 8-oxoguanine DNA glycosylase, N-terminal domain; Region: OGG_N; pfam07934 272562008335 endonuclease III; includes endonuclease III (DNA-(apurinic or apyrimidinic site) lyase), alkylbase DNA glycosidases (Alka-family) and other DNA glycosidases; Region: ENDO3c; cd00056 272562008336 minor groove reading motif; other site 272562008337 helix-hairpin-helix signature motif; other site 272562008338 substrate binding pocket [chemical binding]; other site 272562008339 active site 272562008340 3-hydroxybutyryl-CoA dehydrogenase; Validated; Region: PRK05808 272562008341 3-hydroxyacyl-CoA dehydrogenase, NAD binding domain; Region: 3HCDH_N; pfam02737 272562008342 3-hydroxyacyl-CoA dehydrogenase, C-terminal domain; Region: 3HCDH; pfam00725 272562008343 Electron transfer flavoprotein, alpha subunit [Energy production and conversion]; Region: FixB; COG2025 272562008344 The electron transfer flavoprotein (ETF) serves as a specific electron acceptor for various mitochondrial dehydrogenases. ETF transfers electrons to the main respiratory chain via ETF-ubiquinone oxidoreductase. ETF is an heterodimer that consists of an...; Region: ETF_alpha; cd01715 272562008345 Electron transfer flavoprotein FAD-binding domain; Region: ETF_alpha; pfam00766 272562008346 The electron transfer flavoprotein (ETF) serves as a specific electron acceptor for various mitochondrial dehydrogenases. ETF transfers electrons to the main respiratory chain via ETF-ubiquinone oxidoreductase. ETF is an heterodimer that consists of an...; Region: ETF_beta; cd01714 272562008347 Ligand binding site [chemical binding]; other site 272562008348 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 272562008349 Short chain acyl-CoA dehydrogenases and eukaryotic short/branched chain acyl-CoA dehydrogenases; Region: SCAD_SBCAD; cd01158 272562008350 FAD binding site [chemical binding]; other site 272562008351 homotetramer interface [polypeptide binding]; other site 272562008352 substrate binding pocket [chemical binding]; other site 272562008353 catalytic base [active] 272562008354 3-hydroxybutyryl-CoA dehydratase; Validated; Region: PRK05809 272562008355 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 272562008356 substrate binding site [chemical binding]; other site 272562008357 oxyanion hole (OAH) forming residues; other site 272562008358 trimer interface [polypeptide binding]; other site 272562008359 redox-sensing transcriptional repressor Rex; Provisional; Region: PRK05472 272562008360 Putative DNA-binding protein N-terminus; Region: Put_DNA-bind_N; pfam06971 272562008361 CoA binding domain; Region: CoA_binding; pfam02629 272562008362 ATPase components of ABC transporters with duplicated ATPase domains [General function prediction only]; Region: Uup; COG0488 272562008363 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 272562008364 ABC transporter; Region: ABC_tran_2; pfam12848 272562008365 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 272562008366 This family includes the Gtfs, a group of homologous glycosyltransferases involved in the final stages of the biosynthesis of antibiotics vancomycin and related chloroeremomycin. Gtfs transfer sugar moieties from an activated NDP-sugar donor to the...; Region: GT1_Gtf_like; cd03784 272562008367 glycosyltransferase, MGT family; Region: MGT; TIGR01426 272562008368 active site 272562008369 TDP-binding site; other site 272562008370 acceptor substrate-binding pocket; other site 272562008371 homodimer interface [polypeptide binding]; other site 272562008372 Ethanolamine ammonia-lyase, small subunit [Amino acid transport and metabolism]; Region: EutC; COG4302 272562008373 Ethanolamine ammonia-lyase, large subunit [Amino acid transport and metabolism]; Region: EutB; COG4303 272562008374 ethanolamine permease; Region: 2A0305; TIGR00908 272562008375 Transmembrane amino acid transporter protein; Region: Aa_trans; cl17468 272562008376 Signal transduction histidine kinase; Region: H_kinase_N; pfam12282 272562008377 PAS domain; Region: PAS; smart00091 272562008378 PAS domain S-box; Region: sensory_box; TIGR00229 272562008379 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: COG3920 272562008380 Histidine kinase; Region: HisKA_2; pfam07568 272562008381 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 272562008382 ATP binding site [chemical binding]; other site 272562008383 Mg2+ binding site [ion binding]; other site 272562008384 G-X-G motif; other site 272562008385 Response regulator with putative antiterminator output domain [Signal transduction mechanisms]; Region: AmiR; COG3707 272562008386 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 272562008387 active site 272562008388 phosphorylation site [posttranslational modification] 272562008389 intermolecular recognition site; other site 272562008390 dimerization interface [polypeptide binding]; other site 272562008391 ANTAR domain; Region: ANTAR; pfam03861 272562008392 Alpha-tubulin suppressor and related RCC1 domain-containing proteins [Cell division and chromosome partitioning / Cytoskeleton]; Region: ATS1; COG5184 272562008393 Regulator of chromosome condensation (RCC1) repeat; Region: RCC1_2; pfam13540 272562008394 Regulator of chromosome condensation (RCC1) repeat; Region: RCC1; pfam00415 272562008395 Regulator of chromosome condensation (RCC1) repeat; Region: RCC1; pfam00415 272562008396 Regulator of chromosome condensation (RCC1) repeat; Region: RCC1; pfam00415 272562008397 Regulator of chromosome condensation (RCC1) repeat; Region: RCC1_2; pfam13540 272562008398 dipeptidase PepV; Reviewed; Region: PRK07318 272562008399 M20 Peptidase Xaa-His dipeptidase (PepV) degrades hydrophobic dipeptides; Region: M20_PepV; cd03888 272562008400 active site 272562008401 metal binding site [ion binding]; metal-binding site 272562008402 Hydrolases of the alpha/beta superfamily [General function prediction only]; Region: COG1073 272562008403 Putative lysophospholipase; Region: Hydrolase_4; cl19140 272562008404 Serine hydrolase (FSH1); Region: FSH1; pfam03959 272562008405 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4224 272562008406 histidinol-phosphatase; Provisional; Region: PRK05588 272562008407 Polymerase and Histidinol Phosphatase domain; Region: PHP; cl17102 272562008408 active site 272562008409 Uncharacterized protein with a bacterial SH3 domain homologue [Function unknown]; Region: COG4991 272562008410 Bacterial SH3 domain; Region: SH3_3; pfam08239 272562008411 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 272562008412 Apolipophorin-III and similar insect proteins; Region: ApoLp-III_like; cl19113 272562008413 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 272562008414 dimer interface [polypeptide binding]; other site 272562008415 phosphorylation site [posttranslational modification] 272562008416 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 272562008417 ATP binding site [chemical binding]; other site 272562008418 Mg2+ binding site [ion binding]; other site 272562008419 G-X-G motif; other site 272562008420 MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704 272562008421 FtsX-like permease family; Region: FtsX; pfam02687 272562008422 ABC-type antimicrobial peptide transport system, permease component [Defense mechanisms]; Region: SalY; COG0577 272562008423 FtsX-like permease family; Region: FtsX; pfam02687 272562008424 ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136 272562008425 ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255 272562008426 Walker A/P-loop; other site 272562008427 ATP binding site [chemical binding]; other site 272562008428 Q-loop/lid; other site 272562008429 ABC transporter signature motif; other site 272562008430 Walker B; other site 272562008431 D-loop; other site 272562008432 H-loop/switch region; other site 272562008433 ABC-type transport system involved in multi-copper enzyme maturation, permease component [General function prediction only]; Region: NosY; COG1277 272562008434 ABC-type multidrug transport system, ATPase component [Defense mechanisms]; Region: CcmA; COG1131 272562008435 ATP-binding cassette domain of the bacitracin-resistance transporter; Region: ABC_BcrA_bacitracin_resist; cd03268 272562008436 Walker A/P-loop; other site 272562008437 ATP binding site [chemical binding]; other site 272562008438 Q-loop/lid; other site 272562008439 ABC transporter signature motif; other site 272562008440 Walker B; other site 272562008441 D-loop; other site 272562008442 H-loop/switch region; other site 272562008443 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 272562008444 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 272562008445 active site 272562008446 phosphorylation site [posttranslational modification] 272562008447 intermolecular recognition site; other site 272562008448 dimerization interface [polypeptide binding]; other site 272562008449 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 272562008450 DNA binding site [nucleotide binding] 272562008451 ATPase involved in DNA repair [DNA replication, recombination, and repair]; Region: SbcC; COG0419 272562008452 ATP-binding cassette domain of sbcCD; Region: ABC_sbcCD; cd03279 272562008453 Walker A/P-loop; other site 272562008454 ATP binding site [chemical binding]; other site 272562008455 Q-loop/lid; other site 272562008456 ATP-binding cassette domain of sbcCD; Region: ABC_sbcCD; cd03279 272562008457 ABC transporter signature motif; other site 272562008458 Walker B; other site 272562008459 D-loop; other site 272562008460 H-loop/switch region; other site 272562008461 DNA repair exonuclease [DNA replication, recombination, and repair]; Region: SbcD; COG0420 272562008462 Mre11 nuclease, N-terminal metallophosphatase domain; Region: MPP_Mre11_N; cd00840 272562008463 active site 272562008464 metal binding site [ion binding]; metal-binding site 272562008465 DNA binding site [nucleotide binding] 272562008466 Type 5 capsule protein repressor C-terminal domain; Region: SbcD_C; pfam12320 272562008467 Uncharacterized conserved protein [Function unknown]; Region: COG2013 272562008468 Acetyltransferase (GNAT) domain; Region: Acetyltransf_3; pfam13302 272562008469 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 272562008470 Coenzyme A binding pocket [chemical binding]; other site 272562008471 Histidyl-tRNA synthetase [Translation, ribosomal structure and biogenesis]; Region: HisS; COG0124 272562008472 Class II Histidinyl-tRNA synthetase (HisRS)-like catalytic core domain. HisRS is a homodimer. It is responsible for the attachment of histidine to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for...; Region: HisRS-like_core; cd00773 272562008473 dimer interface [polypeptide binding]; other site 272562008474 motif 1; other site 272562008475 active site 272562008476 motif 2; other site 272562008477 motif 3; other site 272562008478 HGTP anticodon binding domain, as found at the C-terminus of histidyl, glycyl, threonyl and prolyl tRNA synthetases, which are classified as a group of class II aminoacyl-tRNA synthetases (aaRS). In aaRSs, the anticodon binding domain is responsible for...; Region: HGTP_anticodon; cl00266 272562008479 anticodon binding site; other site 272562008480 Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067 272562008481 catalytic core [active] 272562008482 Permeases of the major facilitator superfamily [General function prediction only]; Region: COG2270 272562008483 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 272562008484 putative substrate translocation pore; other site 272562008485 Protein of unknown function (DUF1113); Region: DUF1113; cl19877 272562008486 Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer); Region: MA; smart00283 272562008487 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cl19050 272562008488 dimer interface [polypeptide binding]; other site 272562008489 putative CheW interface [polypeptide binding]; other site 272562008490 Four helix bundle sensory module for signal transduction; Region: 4HB_MCP_1; pfam12729 272562008491 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cl19050 272562008492 Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer); Region: MA; smart00283 272562008493 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cl19050 272562008494 dimer interface [polypeptide binding]; other site 272562008495 putative CheW interface [polypeptide binding]; other site 272562008496 Predicted glycosyl hydrolase [General function prediction only]; Region: COG3858 272562008497 Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118 272562008498 Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118 272562008499 Cortical fragment-lytic enzyme (CFLE) is a peptidoglycan hydrolase involved in bacterial endospore germination. CFLE is expressed as an inactive preprotein (called SleB) in the forespore compartment of sporulating cells. SleB translocates across the...; Region: GH18_CFLE_spore_hydrolase; cd02874 272562008500 active site 272562008501 Superfamily II DNA and RNA helicases [DNA replication, recombination, and repair / Transcription / Translation, ribosomal structure and biogenesis]; Region: SrmB; COG0513 272562008502 DEAD-box helicases. A diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker B motif; Region: DEADc; cd00268 272562008503 ATP binding site [chemical binding]; other site 272562008504 Mg++ binding site [ion binding]; other site 272562008505 motif III; other site 272562008506 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 272562008507 nucleotide binding region [chemical binding]; other site 272562008508 ATP-binding site [chemical binding]; other site 272562008509 RNA recognition motif (RRM) superfamily; Region: RRM_SF; cl17169 272562008510 Escherichia coli YfcE and related proteins, metallophosphatase domain; Region: MPP_YfcE; cd00841 272562008511 active site 272562008512 metal binding site [ion binding]; metal-binding site 272562008513 homotetramer interface [polypeptide binding]; other site 272562008514 Hybrid cluster protein (HCP), formerly known as prismane, is thought to play a role in nitrogen metabolism but its specific function is unknown. HCP has three structural domains, an N-terminal alpha-helical domain, and two similar domains comprising a...; Region: HCP; cd01914 272562008515 cubane metal cluster [ion binding]; other site 272562008516 hybrid metal cluster; other site 272562008517 Acetyltransferase (GNAT) domain; Region: Acetyltransf_8; pfam13523 272562008518 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 272562008519 Coenzyme A binding pocket [chemical binding]; other site 272562008520 Predicted membrane protein [Function unknown]; Region: COG4684 272562008521 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 272562008522 Major Facilitator Superfamily; Region: MFS_1; pfam07690 272562008523 putative substrate translocation pore; other site 272562008524 ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132 272562008525 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 272562008526 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 272562008527 Walker A/P-loop; other site 272562008528 ATP binding site [chemical binding]; other site 272562008529 Q-loop/lid; other site 272562008530 ABC transporter signature motif; other site 272562008531 Walker B; other site 272562008532 D-loop; other site 272562008533 H-loop/switch region; other site 272562008534 ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132 272562008535 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 272562008536 ATP-binding cassette domain of glucan transporter and related proteins, subfamily C; Region: ABCC_Glucan_exporter_like; cd03254 272562008537 Walker A/P-loop; other site 272562008538 ATP binding site [chemical binding]; other site 272562008539 Q-loop/lid; other site 272562008540 ABC transporter signature motif; other site 272562008541 Walker B; other site 272562008542 D-loop; other site 272562008543 H-loop/switch region; other site 272562008544 Predicted secreted protein [Function unknown]; Region: COG4086 272562008545 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 272562008546 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 272562008547 active site 272562008548 phosphorylation site [posttranslational modification] 272562008549 intermolecular recognition site; other site 272562008550 dimerization interface [polypeptide binding]; other site 272562008551 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 272562008552 DNA binding site [nucleotide binding] 272562008553 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 272562008554 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 272562008555 dimerization interface [polypeptide binding]; other site 272562008556 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 272562008557 dimer interface [polypeptide binding]; other site 272562008558 phosphorylation site [posttranslational modification] 272562008559 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 272562008560 ATP binding site [chemical binding]; other site 272562008561 Mg2+ binding site [ion binding]; other site 272562008562 G-X-G motif; other site 272562008563 Membrane-associated lipoprotein involved in thiamine biosynthesis [Coenzyme metabolism]; Region: ApbE; COG1477 272562008564 ferredoxin-type protein, NapH/MauN family; Region: napH_; TIGR02163 272562008565 4Fe-4S binding domain; Region: Fer4_5; pfam12801 272562008566 4Fe-4S binding domain; Region: Fer4_5; pfam12801 272562008567 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3976 272562008568 Four helix bundle sensory module for signal transduction; Region: 4HB_MCP_1; pfam12729 272562008569 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 272562008570 dimerization interface [polypeptide binding]; other site 272562008571 Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer); Region: MA; smart00283 272562008572 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cl19050 272562008573 dimer interface [polypeptide binding]; other site 272562008574 putative CheW interface [polypeptide binding]; other site 272562008575 Four helix bundle sensory module for signal transduction; Region: 4HB_MCP_1; pfam12729 272562008576 Membrane-associated lipoprotein involved in thiamine biosynthesis [Coenzyme metabolism]; Region: ApbE; COG1477 272562008577 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3976 272562008578 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 272562008579 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 272562008580 WHG domain; Region: WHG; pfam13305 272562008581 cyclophilin: cyclophilin-type peptidylprolyl cis- trans isomerases. This family contains eukaryotic, bacterial and archeal proteins which exhibit a peptidylprolyl cis- trans isomerases activity (PPIase, Rotamase) and in addition bind the...; Region: cyclophilin; cd00317 272562008582 active site 272562008583 Xanthine/uracil/vitamin C permease [Nucleotide transport and metabolism]; Region: COG2252 272562008584 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 272562008585 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 272562008586 WHG domain; Region: WHG; pfam13305 272562008587 Cache domain; Region: Cache_2; pfam08269 272562008588 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 272562008589 dimerization interface [polypeptide binding]; other site 272562008590 Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer); Region: MA; smart00283 272562008591 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cl19050 272562008592 dimer interface [polypeptide binding]; other site 272562008593 putative CheW interface [polypeptide binding]; other site 272562008594 Bacillus subtilis YkuE and related proteins, C-terminal metallophosphatase domain; Region: MPP_YkuE_C; cd07385 272562008595 Predicted phosphohydrolases [General function prediction only]; Region: Icc; COG1409 272562008596 putative active site [active] 272562008597 putative metal binding site [ion binding]; other site 272562008598 Disaggregatase related repeat; Region: Disaggr_repeat; pfam06848 272562008599 NrdH-redoxin (NrdH) family; NrdH is a small monomeric protein with a conserved redox active CXXC motif within a TRX fold, characterized by a glutaredoxin (GRX)-like sequence and TRX-like activity profile. In vitro, it displays protein disulfide reductase...; Region: NrdH; cd02976 272562008600 catalytic residues [active] 272562008601 Rubredoxin [Energy production and conversion]; Region: COG1773 272562008602 Rubredoxin; nonheme iron binding domains containing a [Fe(SCys)4] center. Rubredoxins are small nonheme iron proteins. The iron atom is coordinated by four cysteine residues (Fe(S-Cys)4), but iron can also be replaced by cobalt, nickel or zinc. They are...; Region: rubredoxin; cd00730 272562008603 iron binding site [ion binding]; other site 272562008604 Spore coat protein [Cell envelope biogenesis, outer membrane]; Region: COG5577 272562008605 Permeases of the drug/metabolite transporter (DMT) superfamily [Carbohydrate transport and metabolism / Amino acid transport and metabolism / General function prediction only]; Region: RhaT; COG0697 272562008606 EamA-like transporter family; Region: EamA; pfam00892 272562008607 EamA-like transporter family; Region: EamA; pfam00892 272562008608 CGS_like: Cystathionine gamma-synthase is a PLP dependent enzyme and catalyzes the committed step of methionine biosynthesis. This pathway is unique to microorganisms and plants, rendering the enzyme an attractive target for the development of...; Region: CGS_like; cd00614 272562008609 homodimer interface [polypeptide binding]; other site 272562008610 substrate-cofactor binding pocket; other site 272562008611 pyridoxal 5'-phosphate binding site [chemical binding]; other site 272562008612 catalytic residue [active] 272562008613 Type II secretory pathway, prepilin signal peptidase PulO and related peptidases [Cell motility and secretion / Posttranslational modification, protein turnover, chaperones / Intracellular trafficking and secretion]; Region: PulO; COG1989 272562008614 Bacterial Peptidase A24 N-terminal domain; Region: DiS_P_DiS; pfam06750 272562008615 Type IV leader peptidase family; Region: Peptidase_A24; pfam01478 272562008616 Domain of unknown function DUF77; Region: DUF77; pfam01910 272562008617 diadenosine tetraphosphatase; Reviewed; Region: apaH; PRK00166 272562008618 phosphoprotein phosphatases of the metallophosphatase superfamily, metallophosphatase domain; Region: MPP_PPP_family; cd00144 272562008619 active site 272562008620 metal binding site [ion binding]; metal-binding site 272562008621 Xaa-Pro aminopeptidase [Amino acid transport and metabolism]; Region: PepP; COG0006 272562008622 Creatinase/Prolidase N-terminal domain; Region: Creatinase_N; pfam01321 272562008623 Similar to Prolidase and Aminopeptidase P. The members of this subfamily presumably catalyse hydrolysis of Xaa-Pro dipeptides and/or release of any N-terminal amino acid, including proline, that is linked with proline; Region: APP-like; cd01092 272562008624 active site 272562008625 Predicted Fe-S oxidoreductases [General function prediction only]; Region: COG0535 272562008626 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 272562008627 FeS/SAM binding site; other site 272562008628 Predicted membrane protein/domain [Function unknown]; Region: COG1714 272562008629 Transcriptional regulators [Transcription]; Region: Lrp; COG1522 272562008630 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cl17220 272562008631 Transcriptional regulators [Transcription]; Region: Lrp; COG1522 272562008632 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cl17220 272562008633 putative DNA binding site [nucleotide binding]; other site 272562008634 putative Zn2+ binding site [ion binding]; other site 272562008635 putative heme d1 biosynthesis radical SAM protein NirJ2; Region: rSAM_NirJ2; TIGR04055 272562008636 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 272562008637 FeS/SAM binding site; other site 272562008638 radical SAM additional 4Fe4S-binding SPASM domain; Region: rSAM_more_4Fe4S; TIGR04085 272562008639 putative heme d1 biosynthesis radical SAM protein NirJ1; Region: rSAM_NirJ1; TIGR04054 272562008640 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 272562008641 FeS/SAM binding site; other site 272562008642 radical SAM additional 4Fe4S-binding SPASM domain; Region: rSAM_more_4Fe4S; TIGR04085 272562008643 Old yellow enzyme (OYE)-like FMN binding domain. OYE was the first flavin-dependent enzyme identified, however its true physiological role remains elusive to this day. Each monomer of OYE contains FMN as a non-covalently bound cofactor, uses NADPH as a...; Region: OYE_like_FMN_family; cd02803 272562008644 active site 272562008645 FMN binding site [chemical binding]; other site 272562008646 substrate binding site [chemical binding]; other site 272562008647 putative catalytic residue [active] 272562008648 Domain of Unknown Function (DUF1259); Region: DUF1529; pfam07485 272562008649 Manganese catalase, ferritin-like diiron-binding domain; Region: Mn_catalase; cd01051 272562008650 Ferritin-like domain; Region: Ferritin; pfam00210 272562008651 dimanganese center [ion binding]; other site 272562008652 TPR repeat; Region: TPR_11; pfam13414 272562008653 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 272562008654 TPR motif; other site 272562008655 Tetratricopeptide repeat; Region: TPR_12; pfam13424 272562008656 binding surface 272562008657 Phosphoglycerol transferase and related proteins, alkaline phosphatase superfamily [Cell envelope biogenesis, outer membrane]; Region: MdoB; COG1368 272562008658 Sulfatase; Region: Sulfatase; pfam00884 272562008659 ligand binding domain of Tar- and Tsr-related chemoreceptors; Region: Tar_Tsr_LBD; cl00144 272562008660 Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer); Region: MA; smart00283 272562008661 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cl19050 272562008662 dimer interface [polypeptide binding]; other site 272562008663 putative CheW interface [polypeptide binding]; other site 272562008664 Metallo-beta-lactamase superfamily; Region: Lactamase_B; smart00849 272562008665 Selenocysteine lyase/Cysteine desulfurase [Posttranslational modification, protein turnover, chaperones]; Region: csdA; COG0520 272562008666 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 272562008667 catalytic residue [active] 272562008668 Saccharomyces cerevisiae DCR2 phosphatase and related proteins, metallophosphatase domain; Region: MPP_Dcr2; cd07383 272562008669 Predicted phosphohydrolases [General function prediction only]; Region: Icc; COG1409 272562008670 putative active site [active] 272562008671 putative metal binding site [ion binding]; other site 272562008672 Beta-glucanase/Beta-glucan synthetase [Carbohydrate transport and metabolism]; Region: SKN1; COG2273 272562008673 lichenase, member of glycosyl hydrolase family 16; Region: GH16_lichenase; cd02175 272562008674 active site 272562008675 active site 272562008676 catalytic residues [active] 272562008677 Beta-lactamase; Region: Beta-lactamase; pfam00144 272562008678 Predicted HD superfamily hydrolase involved in NAD metabolism [Coenzyme metabolism]; Region: COG1713 272562008679 Glucoamylase and related glycosyl hydrolases [Carbohydrate transport and metabolism]; Region: SGA1; COG3387 272562008680 Lipoproteins [Cell envelope biogenesis, outer membrane]; Region: RlpA; COG0797 272562008681 AraC-like ligand binding domain; Region: AraC_binding; pfam02311 272562008682 AraC-type DNA-binding domain-containing proteins [Transcription]; Region: AraC; COG2207 272562008683 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 272562008684 UDP-N-acetylmuramoylalanyl-D-glutamate--2, 6-diaminopimelate ligase; Provisional; Region: murE; PRK00139 272562008685 Mur ligase family, catalytic domain; Region: Mur_ligase; pfam01225 272562008686 Mur ligase middle domain; Region: Mur_ligase_M; pfam08245 272562008687 Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875 272562008688 Xanthine/uracil/vitamin C permease [Nucleotide transport and metabolism]; Region: COG2252 272562008689 Cache domain; Region: Cache_1; pfam02743 272562008690 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 272562008691 dimerization interface [polypeptide binding]; other site 272562008692 Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer); Region: MA; smart00283 272562008693 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 272562008694 dimer interface [polypeptide binding]; other site 272562008695 putative CheW interface [polypeptide binding]; other site 272562008696 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 272562008697 binding surface 272562008698 TPR motif; other site 272562008699 Tetratricopeptide repeat; Region: TPR_12; pfam13424 272562008700 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 272562008701 binding surface 272562008702 Tetratricopeptide repeat; Region: TPR_16; pfam13432 272562008703 TPR motif; other site 272562008704 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 272562008705 binding surface 272562008706 TPR motif; other site 272562008707 Nucleoside Triphosphate Pyrophosphohydrolase (EC 3.6.1.8) MazG-like domain found in a group of uncharacterized proteins from archaea and bacteria; Region: NTP-PPase_COG4997; cd11532 272562008708 metal binding site [ion binding]; metal-binding site 272562008709 N-terminal putative catalytic domain of uncharacterized prokaryotic and archeal HKD family nucleases fused to a DEAD/DEAH box helicase domain; Region: PLDc_N_DEXD_b3; cd09205 272562008710 PLD-like domain; Region: PLDc_2; pfam13091 272562008711 putative homodimer interface [polypeptide binding]; other site 272562008712 putative active site [active] 272562008713 catalytic site [active] 272562008714 DEAD-like helicases superfamily; Region: DEXDc; smart00487 272562008715 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 272562008716 ATP binding site [chemical binding]; other site 272562008717 putative Mg++ binding site [ion binding]; other site 272562008718 Superfamily II DNA and RNA helicases [DNA replication, recombination, and repair / Transcription / Translation, ribosomal structure and biogenesis]; Region: SrmB; COG0513 272562008719 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 272562008720 nucleotide binding region [chemical binding]; other site 272562008721 ATP-binding site [chemical binding]; other site 272562008722 hypothetical protein; Validated; Region: PRK00124 272562008723 DJ-1 family protein; Region: not_thiJ; TIGR01383 272562008724 Type 1 glutamine amidotransferase (GATase1)-like domain found in a subgroup of proteins similar to PfpI from Pyrococcus furiosus; Region: GATase1_PfpI_2; cd03139 272562008725 conserved cys residue [active] 272562008726 Methyltransferase domain; Region: Methyltransf_31; pfam13847 272562008727 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 272562008728 S-adenosylmethionine binding site [chemical binding]; other site 272562008729 The MutT pyrophosphohydrolase is a prototypical Nudix hydrolase that catalyzes the hydrolysis of nucleoside and deoxynucleoside triphosphates (NTPs and dNTPs) by substitution at a beta-phosphorus to yield a nucleotide monophosphate (NMP) and inorganic...; Region: MutT_pyrophosphohydrolase; cd03425 272562008730 active site 272562008731 8-oxo-dGMP binding site [chemical binding]; other site 272562008732 nudix motif; other site 272562008733 metal binding site [ion binding]; metal-binding site 272562008734 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cl00462 272562008735 RNA recognition motif (RRM) superfamily; Region: RRM_SF; cl17169 272562008736 Acylphosphatases [Energy production and conversion]; Region: AcyP; COG1254 272562008737 Bacterial BAX inhibitor (BI)-1/YccA-like proteins; Region: BI-1-like_bacterial; cd10432 272562008738 aspartate aminotransferase; Provisional; Region: PRK06836 272562008739 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 272562008740 pyridoxal 5'-phosphate binding site [chemical binding]; other site 272562008741 homodimer interface [polypeptide binding]; other site 272562008742 catalytic residue [active] 272562008743 Sugar diacid utilization regulator [Transcription / Signal transduction mechanisms]; Region: CdaR; COG3835 272562008744 Putative sugar diacid recognition; Region: Diacid_rec; pfam05651 272562008745 PucR C-terminal helix-turn-helix domain; Region: HTH_30; pfam13556 272562008746 Glycerate kinase [Carbohydrate transport and metabolism]; Region: COG1929 272562008747 ABC-type metal ion transport system, periplasmic component/surface adhesin [Inorganic ion transport and metabolism]; Region: LraI; COG0803 272562008748 Periplasmic solute binding protein family; Region: TroA; pfam01297 272562008749 intersubunit interface [polypeptide binding]; other site 272562008750 c-di-GMP phosphodiesterase class II (HD-GYP domain) [Signal transduction mechanisms]; Region: COG2206 272562008751 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 272562008752 Zn2+ binding site [ion binding]; other site 272562008753 Mg2+ binding site [ion binding]; other site 272562008754 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 272562008755 Zn2+ binding site [ion binding]; other site 272562008756 Mg2+ binding site [ion binding]; other site 272562008757 Predicted ATPase or kinase [General function prediction only]; Region: COG0802 272562008758 tRNA threonylcarbamoyl adenosine modification protein YeaZ; Region: T6A_YeaZ; TIGR03725 272562008759 Glycoprotease family; Region: Peptidase_M22; pfam00814 272562008760 ribosomal-protein-alanine acetyltransferase; Region: rimI; TIGR01575 272562008761 Mpr1p, Pad1p N-terminal (MPN) domains; Region: MPN; cl13996 272562008762 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 272562008763 Coenzyme A binding pocket [chemical binding]; other site 272562008764 hypothetical protein; Region: PHA01807 272562008765 Predicted membrane protein [Function unknown]; Region: COG3601 272562008766 Transcriptional accessory protein [Transcription]; Region: Tex; COG2183 272562008767 Tex-like protein N-terminal domain; Region: Tex_N; pfam09371 272562008768 Likely ribonuclease with RNase H fold; Region: YqgFc; smart00732 272562008769 Helix-hairpin-helix motif; Region: HHH_3; pfam12836 272562008770 S1_Tex: The C-terminal S1 domain of a transcription accessory factor called Tex, which has been characterized in Bordetella pertussis and Pseudomonas aeruginosa. The tex gene is essential in Bortella pertusis and is named for its role in toxin expression; Region: S1_Tex; cd05685 272562008771 RNA binding site [nucleotide binding]; other site 272562008772 Predicted aminopeptidases [General function prediction only]; Region: Iap; COG2234 272562008773 M28 Zn-Peptidases containing a PA domain insert; Region: M28_like_PA; cd03877 272562008774 metal binding site [ion binding]; metal-binding site 272562008775 Galactose-1-phosphate uridylyltransferase [Energy production and conversion]; Region: GalT; COG1085 272562008776 Galactose-1-phosphate uridyl transferase (GalT): This enzyme plays a key role in galactose metabolism by catalysing the transfer of a uridine 5'-phosphoryl group from UDP-galactose 1-phosphate. The structure of E.coli GalT reveals that the enzyme...; Region: GalT; cd00608 272562008777 dimer interface [polypeptide binding]; other site 272562008778 active site 272562008779 peptide chain release factor 2; Provisional; Region: PRK05589 272562008780 This domain is found in peptide chain release factors; Region: PCRF; smart00937 272562008781 RF-1 domain; Region: RF-1; pfam00472 272562008782 preprotein translocase subunit SecA; Reviewed; Region: PRK12904 272562008783 SecA preprotein cross-linking domain; Region: SecA_PP_bind; smart00958 272562008784 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 272562008785 nucleotide binding region [chemical binding]; other site 272562008786 ATP-binding site [chemical binding]; other site 272562008787 SecA Wing and Scaffold domain; Region: SecA_SW; pfam07516 272562008788 SEC-C motif; Region: SEC-C; pfam02810 272562008789 RaiA ("ribosome-associated inhibitor A", also known as Protein Y (PY), YfiA, and SpotY, is a stress-response protein that binds the ribosomal subunit interface and arrests translation by interfering with aminoacyl-tRNA binding to the ribosomal...; Region: RaiA; cd00552 272562008790 30S subunit binding site; other site 272562008791 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 272562008792 dimer interface [polypeptide binding]; other site 272562008793 conserved gate region; other site 272562008794 putative PBP binding loops; other site 272562008795 ABC-ATPase subunit interface; other site 272562008796 Periplasmic glycine betaine/choline-binding (lipo)protein of an ABC-type transport system (osmoprotectant binding protein) [Cell envelope biogenesis, outer membrane]; Region: OpuBC; COG1732 272562008797 ABC-type proline/glycine betaine transport systems, ATPase components [Amino acid transport and metabolism]; Region: OpuBA; COG1125 272562008798 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 272562008799 Walker A/P-loop; other site 272562008800 ATP binding site [chemical binding]; other site 272562008801 Q-loop/lid; other site 272562008802 ABC transporter signature motif; other site 272562008803 Walker B; other site 272562008804 D-loop; other site 272562008805 H-loop/switch region; other site 272562008806 FOG: CBS domain [General function prediction only]; Region: COG0517 272562008807 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains in association with the ABC transporter OpuCA. OpuCA is the ATP binding component of a bacterial solute transporter that serves a protective role to cells growing...; Region: CBS_pair_ABC_OpuCA_assoc2; cd04583 272562008808 Predicted transcriptional regulators [Transcription]; Region: COG1725 272562008809 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cl17414 272562008810 DNA-binding site [nucleotide binding]; DNA binding site 272562008811 Putative regulatory, ligand-binding protein related to C-terminal domains of K+ channels [Inorganic ion transport and metabolism]; Region: COG0490 272562008812 TrkA-C domain; Region: TrkA_C; pfam02080 272562008813 Predicted amidophosphoribosyltransferases [General function prediction only]; Region: ComFC; COG1040 272562008814 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 272562008815 active site 272562008816 Superfamily II DNA/RNA helicase required for DNA uptake (late competence protein) [DNA replication, recombination, and repair]; Region: comFA; COG4098 272562008817 helicase, putative, RecD/TraA family; Region: recD_rel; TIGR01448 272562008818 Helix-hairpin-helix domain; Region: HHH_5; pfam14520 272562008819 DNA binding site [nucleotide binding] 272562008820 Helix-hairpin-helix containing domain; Region: HHH_4; pfam14490 272562008821 AAA domain; Region: AAA_30; pfam13604 272562008822 UvrD-like helicase C-terminal domain; Region: UvrD_C_2; pfam13538 272562008823 S-adenosylmethionine synthetase; Validated; Region: PRK05250 272562008824 S-adenosylmethionine synthetase, N-terminal domain; Region: S-AdoMet_synt_N; pfam00438 272562008825 S-adenosylmethionine synthetase, central domain; Region: S-AdoMet_synt_M; pfam02772 272562008826 S-adenosylmethionine synthetase, C-terminal domain; Region: S-AdoMet_synt_C; pfam02773 272562008827 Protein of unknown function (DUF1256); Region: DUF1256; pfam06866 272562008828 rod shape-determining protein Mbl; Provisional; Region: PRK13928 272562008829 MreB and similar proteins; Region: MreB_like; cd10225 272562008830 nucleotide binding site [chemical binding]; other site 272562008831 Mg binding site [ion binding]; other site 272562008832 putative protofilament interaction site [polypeptide binding]; other site 272562008833 RodZ interaction site [polypeptide binding]; other site 272562008834 sporulation transcriptional regulator SpoIIID; Region: spore_III_D; TIGR02844 272562008835 Peptidase family M23; Region: Peptidase_M23; pfam01551 272562008836 stage II sporulation protein D; Region: spore_II_D; TIGR02870 272562008837 Stage II sporulation protein; Region: SpoIID; pfam08486 272562008838 EPSP synthase (3-phosphoshikimate 1-carboxyvinyltransferase); Region: EPSP_synthase; pfam00275 272562008839 UDP-N-acetylglucosamine enolpyruvyl transferase catalyzes enolpyruvyl transfer as part of the first step in the biosynthesis of peptidoglycan, a component of the bacterial cell wall. The reaction is phosphoenolpyruvate + UDP-N-acetyl-D-glucosamine =...; Region: UdpNAET; cd01555 272562008840 hinge; other site 272562008841 active site 272562008842 Chlamydia virulence protein PGP3-D; Region: Chlam_vir; pfam05475 272562008843 Protein of unknown function (DUF1779); Region: DUF1779; pfam08680 272562008844 F0F1 ATP synthase subunit epsilon; Provisional; Region: atpC; PRK13450 272562008845 mitochondrial ATP synthase delta subunit; Region: F1-ATPase_delta; cd12152 272562008846 gamma subunit interface [polypeptide binding]; other site 272562008847 epsilon subunit interface [polypeptide binding]; other site 272562008848 LBP interface [polypeptide binding]; other site 272562008849 F0F1 ATP synthase subunit beta; Validated; Region: PRK09280 272562008850 ATP synthase alpha/beta family, beta-barrel domain; Region: ATP-synt_ab_N; pfam02874 272562008851 F1 ATP synthase beta subunit, nucleotide-binding domain. The F-ATPase is found in bacterial plasma membranes, mitochondrial inner membranes and in chloroplast thylakoid membranes. It has also been found in the archaea Methanosarcina barkeri. It uses a...; Region: F1-ATPase_beta; cd01133 272562008852 alpha subunit interaction interface [polypeptide binding]; other site 272562008853 Walker A motif; other site 272562008854 ATP binding site [chemical binding]; other site 272562008855 Walker B motif; other site 272562008856 inhibitor binding site; inhibition site 272562008857 ATP synthase alpha/beta chain, C terminal domain; Region: ATP-synt_ab_C; pfam00306 272562008858 mitochondrial ATP synthase gamma subunit; Region: F1-ATPase_gamma; cd12151 272562008859 core domain interface [polypeptide binding]; other site 272562008860 delta subunit interface [polypeptide binding]; other site 272562008861 epsilon subunit interface [polypeptide binding]; other site 272562008862 F0F1 ATP synthase subunit alpha; Validated; Region: PRK09281 272562008863 ATP synthase alpha/beta family, beta-barrel domain; Region: ATP-synt_ab_N; pfam02874 272562008864 F1 ATP synthase alpha, central domain. The F-ATPase is found in bacterial plasma membranes, mitochondrial inner membranes and in chloroplast thylakoid membranes. It has also been found in the archaea Methanosarcina barkeri. It uses a proton gradient to...; Region: F1_ATPase_alpha; cd01132 272562008865 beta subunit interaction interface [polypeptide binding]; other site 272562008866 Walker A motif; other site 272562008867 ATP binding site [chemical binding]; other site 272562008868 Walker B motif; other site 272562008869 ATP synthase alpha/beta chain, C terminal domain; Region: ATP-synt_ab_C; pfam00306 272562008870 F0F1-type ATP synthase, delta subunit (mitochondrial oligomycin sensitivity protein) [Energy production and conversion]; Region: AtpH; COG0712 272562008871 F0F1 ATP synthase subunit B; Provisional; Region: PRK13461 272562008872 F0F1-type ATP synthase, subunit b [Energy production and conversion]; Region: AtpF; COG0711 272562008873 F0F1 ATP synthase subunit C; Provisional; Region: PRK13469 272562008874 F0F1-type ATP synthase, subunit a [Energy production and conversion]; Region: AtpB; COG0356 272562008875 putative acyltransferase; Provisional; Region: PRK05790 272562008876 Thiolase are ubiquitous enzymes that catalyze the reversible thiolytic cleavage of 3-ketoacyl-CoA into acyl-CoA and acetyl-CoA, a 2-step reaction involving a covalent intermediate formed with a catalytic cysteine. They are found in prokaryotes and...; Region: thiolase; cd00751 272562008877 dimer interface [polypeptide binding]; other site 272562008878 active site 272562008879 UDP-N-acetylglucosamine 2-epimerase [Cell envelope biogenesis, outer membrane]; Region: WecB; COG0381 272562008880 Bacterial members of the UDP-N-Acetylglucosamine (GlcNAc) 2-Epimerase family are known to catalyze the reversible interconversion of UDP-GlcNAc and UDP-N-acetylmannosamine (UDP-ManNAc). The enzyme serves to produce an activated form of ManNAc residues; Region: GT1_UDP-GlcNAc_2-Epimerase; cd03786 272562008881 active site 272562008882 homodimer interface [polypeptide binding]; other site 272562008883 undecaprenyl-phosphate alpha-N-acetylglucosaminyl 1-phosphatetransferase; Region: ECA_wecA; TIGR02380 272562008884 This subfamily contains Escherichia coli WecA, Bacillus subtilis TagO and related proteins. WecA is an UDP-N-acetylglucosamine (GlcNAc):undecaprenyl-phosphate (Und-P) GlcNAc-1-phosphate transferase that catalyzes the formation of a phosphodiester bond...; Region: GT_WecA_like; cd06853 272562008885 Mg++ binding site [ion binding]; other site 272562008886 putative catalytic motif [active] 272562008887 substrate binding site [chemical binding]; other site 272562008888 Deoxycytidylate deaminase domain. Deoxycytidylate deaminase catalyzes the deamination of dCMP to dUMP, providing the nucleotide substrate for thymidylate synthase. The enzyme binds Zn++, which is required for catalytic activity. The activity of the...; Region: deoxycytidylate_deaminase; cd01286 272562008889 catalytic motif [active] 272562008890 Zn binding site [ion binding]; other site 272562008891 ABC-type cobalt transport system, ATPase component [Inorganic ion transport and metabolism]; Region: CbiO; COG1122 272562008892 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 272562008893 Walker A/P-loop; other site 272562008894 ATP binding site [chemical binding]; other site 272562008895 Q-loop/lid; other site 272562008896 ABC transporter signature motif; other site 272562008897 Walker B; other site 272562008898 D-loop; other site 272562008899 H-loop/switch region; other site 272562008900 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550 272562008901 ABC-ATPase subunit interface; other site 272562008902 dimer interface [polypeptide binding]; other site 272562008903 putative PBP binding regions; other site 272562008904 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 272562008905 active site 272562008906 ribose-5-phosphate isomerase B; Provisional; Region: PRK05571 272562008907 Low molecular weight phosphatase family; Region: LMWPc; cd00115 272562008908 active site 272562008909 Putative translation factor (SUA5) [Translation, ribosomal structure and biogenesis]; Region: SUA5; COG0009 272562008910 Putative GTP-binding controlling metal-binding; Region: SUA5; pfam03481 272562008911 peptide chain release factor 1; Validated; Region: prfA; PRK00591 272562008912 This domain is found in peptide chain release factors; Region: PCRF; smart00937 272562008913 RF-1 domain; Region: RF-1; pfam00472 272562008914 N5-glutamine S-adenosyl-L-methionine-dependent methyltransferase; Provisional; Region: PRK09328 272562008915 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 272562008916 S-adenosylmethionine binding site [chemical binding]; other site 272562008917 Predicted metal-dependent enzyme [General function prediction only]; Region: COG3872 272562008918 thymidine kinase; Provisional; Region: PRK04296 272562008919 50S ribosomal protein L31; Reviewed; Region: rpmE; PRK00019 272562008920 transcription termination factor Rho; Provisional; Region: rho; PRK09376 272562008921 Rho termination factor, N-terminal domain; Region: Rho_N; pfam07498 272562008922 Rho_CSD: Rho protein cold-shock domain (CSD). Rho protein is a transcription termination factor in most bacteria. In bacteria, there are two distinct mechanisms for mRNA transcription termination. In intrinsic termination, RNA polymerase and nascent mRNA...; Region: Rho_CSD; cd04459 272562008923 RNA binding site [nucleotide binding]; other site 272562008924 Transcription termination factor rho is a bacterial ATP-dependent RNA/DNA helicase. It is a homohexamer. Each monomer consists of an N-terminal domain of the OB fold, which is responsible for binding to cysteine rich nucleotides. This alignment is of the...; Region: rho_factor; cd01128 272562008925 multimer interface [polypeptide binding]; other site 272562008926 Walker A motif; other site 272562008927 ATP binding site [chemical binding]; other site 272562008928 Walker B motif; other site 272562008929 Alpha-glucosidases, family 31 of glycosyl hydrolases [Carbohydrate transport and metabolism]; Region: COG1501 272562008930 The enzymes of glycosyl hydrolase family 31 (GH31) occur in prokaryotes, eukaryotes, and archaea with a wide range of hydrolytic activities, including alpha-glucosidase (glucoamylase and sucrase-isomaltase), alpha-xylosidase, 6-alpha-glucosyltransferase; Region: GH31; cl11402 272562008931 active site 272562008932 catalytic site [active] 272562008933 S-layer domain [Cell envelope biogenesis, outer membrane]; Region: COG1361 272562008934 Chitobiase/beta-hexosaminidase C-terminal domain; Region: CHB_HEX_C; pfam03174 272562008935 Fn3 associated; Region: Fn3_assoc; pfam13287 272562008936 CTP synthetase; Validated; Region: pyrG; PRK05380 272562008937 CTP synthetase (CTPs) is a two-domain protein, which consists of an N-terminal synthetase domain and C-terminal glutaminase domain. The enzymes hydrolyze the amide bond of glutamine to ammonia and glutamate at the glutaminase domains and transfer nascent...; Region: CTGs; cd03113 272562008938 Catalytic site [active] 272562008939 active site 272562008940 UTP binding site [chemical binding]; other site 272562008941 Type 1 glutamine amidotransferase (GATase1) domain found in Cytidine Triphosphate Synthetase; Region: GATase1_CTP_Synthase; cd01746 272562008942 active site 272562008943 putative oxyanion hole; other site 272562008944 catalytic triad [active] 272562008945 Catalytic NodB homology domain of the carbohydrate esterase 4 superfamily; Region: CE4_SF; cl15692 272562008946 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4506 272562008947 D-alanyl-alanine synthetase A; Reviewed; Region: ddl; PRK01966 272562008948 D-ala D-ala ligase N-terminus; Region: Dala_Dala_lig_N; pfam01820 272562008949 D-ala D-ala ligase C-terminus; Region: Dala_Dala_lig_C; pfam07478 272562008950 germination protein YpeB; Region: spore_YpeB; TIGR02889 272562008951 YpeB sporulation; Region: YPEB; pfam14620 272562008952 UDP-N-acetylglucosamine:LPS N-acetylglucosamine transferase [Cell envelope biogenesis, outer membrane]; Region: MurG; COG0707 272562008953 Monogalactosyldiacylglycerol (MGDG) synthase; Region: MGDG_synth; pfam06925 272562008954 Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013 272562008955 stage II sporulation protein R; Region: spore_II_R; TIGR02837 272562008956 Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118 272562008957 spore photoproduct lyase; Region: photo_TT_lyase; cl15393 272562008958 DNA repair photolyase [DNA replication, recombination, and repair]; Region: SplB; COG1533 272562008959 spore photoproduct lyase; Region: photo_TT_lyase; cl15393 272562008960 Complex I intermediate-associated protein 30 (CIA30); Region: CIA30; pfam08547 272562008961 4-diphosphocytidyl-2-C-methyl-D-erythritol kinase; Provisional; Region: ipk; PRK00128 272562008962 GHMP kinases N terminal domain; Region: GHMP_kinases_N; pfam00288 272562008963 GHMP kinases C terminal; Region: GHMP_kinases_C; pfam08544 272562008964 Domain of unknown function (DUF3794); Region: DUF3794; pfam12673 272562008965 Domain of unknown function (DUF3794); Region: DUF3794; pfam12673 272562008966 Domain of unknown function (DUF3794); Region: DUF3794; pfam12673 272562008967 Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118 272562008968 Protein of unknown function (DUF1021); Region: DUF1021; pfam06257 272562008969 sporulation peptidase YabG; Region: spore_yabG; TIGR02855 272562008970 Aminoglycoside 3'-phosphotransferase (APH) and Choline Kinase (ChoK) family. The APH/ChoK family is part of a larger superfamily that includes the catalytic domains of other kinases, such as the typical serine/threonine/tyrosine protein kinases (PKs)...; Region: APH_ChoK_like; cd05120 272562008971 active site 272562008972 substrate binding site [chemical binding]; other site 272562008973 Phosphotransferase enzyme family; Region: APH; pfam01636 272562008974 ATP binding site [chemical binding]; other site 272562008975 This family is most closely related to the GT1 family of glycosyltransferases. mtfB (mannosyltransferase B) in E. coli has been shown to direct the growth of the O9-specific polysaccharide chain. It transfers two mannoses into the position 3 of the...; Region: GT1_mtfB_like; cd03809 272562008976 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 272562008977 spore coat protein YsxE; Region: spore_ysxE; TIGR02904 272562008978 Aminoglycoside 3'-phosphotransferase (APH) and Choline Kinase (ChoK) family. The APH/ChoK family is part of a larger superfamily that includes the catalytic domains of other kinases, such as the typical serine/threonine/tyrosine protein kinases (PKs)...; Region: APH_ChoK_like; cd05120 272562008979 Aminoglycoside 3'-phosphotransferase (APH) and Choline Kinase (ChoK) family. The APH/ChoK family is part of a larger superfamily that includes the catalytic domains of other kinases, such as the typical serine/threonine/tyrosine protein kinases (PKs)...; Region: APH_ChoK_like; cl17270 272562008980 spore coat protein YsxE; Region: spore_ysxE; TIGR02904 272562008981 Phosphotransferase enzyme family; Region: APH; pfam01636 272562008982 Aminoglycoside 3'-phosphotransferase (APH) and Choline Kinase (ChoK) family. The APH/ChoK family is part of a larger superfamily that includes the catalytic domains of other kinases, such as the typical serine/threonine/tyrosine protein kinases (PKs)...; Region: APH_ChoK_like; cd05120 272562008983 active site 272562008984 ATP binding site [chemical binding]; other site 272562008985 substrate binding site [chemical binding]; other site 272562008986 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 272562008987 This family is most closely related to the GT1 family of glycosyltransferases. mtfB (mannosyltransferase B) in E. coli has been shown to direct the growth of the O9-specific polysaccharide chain. It transfers two mannoses into the position 3 of the...; Region: GT1_mtfB_like; cd03809 272562008988 ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653 272562008989 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; pfam01547 272562008990 Ketopantoate hydroxymethyltransferase (KPHMT) is the first enzyme in the pantothenate biosynthesis pathway. Ketopantoate hydroxymethyltransferase (KPHMT) catalyzes the first committed step in the biosynthesis of pantothenate (vitamin B5), which is a...; Region: KPHMT-like; cd06557 272562008991 oligomerization interface [polypeptide binding]; other site 272562008992 active site 272562008993 metal binding site [ion binding]; metal-binding site 272562008994 Pantoate-beta-alanine ligase; Region: PanC; cd00560 272562008995 active site 272562008996 ATP-binding site [chemical binding]; other site 272562008997 pantoate-binding site; other site 272562008998 HXXH motif; other site 272562008999 Aspartate alpha-decarboxylase or L-aspartate 1-decarboxylase, a pyruvoyl group-dependent decarboxylase in beta-alanine production; Region: Asp_decarbox; cd06919 272562009000 tetramerization interface [polypeptide binding]; other site 272562009001 active site 272562009002 Esterase/lipase [Lipid metabolism]; Region: Aes; COG0657 272562009003 Prolyl oligopeptidase family; Region: Peptidase_S9; cl19144 272562009004 Prolyl oligopeptidase family; Region: Peptidase_S9; cl19144 272562009005 Phosphomannose isomerase [Carbohydrate transport and metabolism]; Region: ManA; COG1482 272562009006 Alpha-Mannosidase Binding Domain of Atg19/34; Region: ABD; cl19057 272562009007 Protein of unknown function (DUF2971); Region: DUF2971; pfam11185 272562009008 Thiamine monophosphate synthase (TMP synthase)/TenI. TMP synthase catalyzes an important step in the thiamine biosynthesis pathway, the substitution of the pyrophosphate of 2-methyl-4-amino-5- hydroxymethylpyrimidine pyrophosphate by 4-methyl-5-; Region: TMP_TenI; cd00564 272562009009 thiamine phosphate binding site [chemical binding]; other site 272562009010 active site 272562009011 pyrophosphate binding site [ion binding]; other site 272562009012 thiamine biosynthesis protein ThiH; Reviewed; Region: thiH; PRK09240 272562009013 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 272562009014 FeS/SAM binding site; other site 272562009015 Biotin and Thiamin Synthesis associated domain; Region: BATS; pfam06968 272562009016 Thiazole synthase (ThiG) is the tetrameric enzyme that is involved in the formation of the thiazole moiety of thiamin pyrophosphate, an essential ubiquitous cofactor that plays an important role in carbohydrate and amino acid metabolism. ThiG catalyzes...; Region: ThiG; cd04728 272562009017 ThiS interaction site; other site 272562009018 putative active site [active] 272562009019 tetramer interface [polypeptide binding]; other site 272562009020 ThiS-like ubiquitin; Region: ThiS-like; pfam14453 272562009021 thiamine biosynthesis protein ThiF; Provisional; Region: PRK08644 272562009022 E1_ThiF_like. Member of superfamily of activating enzymes (E1) of the ubiquitin-like proteins. The common reaction mechanism catalyzed by E1-like enzymes begins with a nucleophilic attack of the C-terminal carboxylate of the ubiquitin-like substrate, on...; Region: E1_ThiF_like; cd01487 272562009023 putative ATP binding site [chemical binding]; other site 272562009024 putative substrate interface [chemical binding]; other site 272562009025 ThiaminS ubiquitin-like sulfur carrier protein; Region: ThiS; cd00565 272562009026 thiS-thiF/thiG interaction site; other site 272562009027 Predicted HD superfamily hydrolase [General function prediction only]; Region: COG1418 272562009028 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 272562009029 Zn2+ binding site [ion binding]; other site 272562009030 Mg2+ binding site [ion binding]; other site 272562009031 Dihydropteroate synthase and related enzymes [Coenzyme metabolism]; Region: FolP; COG0294 272562009032 DHPS subgroup of Pterin binding enzymes. DHPS (dihydropteroate synthase), a functional homodimer, catalyzes the condensation of p-aminobenzoic acid (pABA) in the de novo biosynthesis of folate, which is an essential cofactor in both nucleic acid and...; Region: DHPS; cd00739 272562009033 substrate binding pocket [chemical binding]; other site 272562009034 dimer interface [polypeptide binding]; other site 272562009035 inhibitor binding site; inhibition site 272562009036 Dihydroneopterin aldolase (DHNA) and 7,8-dihydroneopterin triphosphate epimerase domain (DHNTPE); these enzymes have been designated folB and folX, respectively. Folate derivatives are essential cofactors in the biosynthesis of purines, pyrimidines, and...; Region: DHNA_DHNTPE; cd00534 272562009037 homooctamer interface [polypeptide binding]; other site 272562009038 active site 272562009039 7,8-dihydro-6-hydroxymethylpterin-pyrophosphokinase (HPPK). Folate derivatives are essential cofactors in the biosynthesis of purines, pyrimidines, and amino acids as well as formyl-tRNA. Mammalian cells are able to utilize pre-formed folates after...; Region: HPPK; cd00483 272562009040 catalytic center binding site [active] 272562009041 ATP binding site [chemical binding]; other site 272562009042 Predicted membrane protein [Function unknown]; Region: COG3859 272562009043 ABC-type Na+ efflux pump, permease component [Energy production and conversion / Inorganic ion transport and metabolism]; Region: NatB; COG1668 272562009044 YhgE/Pip N-terminal domain; Region: pip_yhgE_Nterm; cl19580 272562009045 ABC-2 type transporter; Region: ABC2_membrane; cl17235 272562009046 YhgE/Pip N-terminal domain; Region: pip_yhgE_Nterm; cl19580 272562009047 ABC-2 family transporter protein; Region: ABC2_membrane_3; pfam12698 272562009048 ABC-2 type transporter; Region: ABC2_membrane; cl17235 272562009049 ABC-type multidrug transport system, ATPase component [Defense mechanisms]; Region: CcmA; COG1131 272562009050 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 272562009051 Walker A/P-loop; other site 272562009052 ATP binding site [chemical binding]; other site 272562009053 Q-loop/lid; other site 272562009054 ABC transporter signature motif; other site 272562009055 Walker B; other site 272562009056 D-loop; other site 272562009057 H-loop/switch region; other site 272562009058 4Fe-4S dicluster domain; Region: Fer4_9; pfam13187 272562009059 4Fe-4S dicluster domain; Region: Fer4_17; pfam13534 272562009060 Nitroreductase family. Members of this family utilize FMN as a cofactor. This family is involved in the reduction of flavin or nitroaromatic compounds by using NAD(P)H as electron donor in a obligatory two-electron transfer. Nitrogenase is homodimer; Region: NADH_nitroreductase; cd02143 272562009061 putative FMN binding site [chemical binding]; other site 272562009062 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 272562009063 dimerization interface [polypeptide binding]; other site 272562009064 putative DNA binding site [nucleotide binding]; other site 272562009065 putative Zn2+ binding site [ion binding]; other site 272562009066 Acetyltransferase (GNAT) domain; Region: Acetyltransf_10; pfam13673 272562009067 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 272562009068 Coenzyme A binding pocket [chemical binding]; other site 272562009069 Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596 272562009070 Ketopantoate reductase PanE/ApbA; Region: ApbA; pfam02558 272562009071 2-dehydropantoate 2-reductase; Region: apbA_panE; TIGR00745 272562009072 Ketopantoate reductase PanE/ApbA C terminal; Region: ApbA_C; pfam08546 272562009073 Uncharacterized protein involved in plasmid maintenance [General function prediction only]; Region: SMP2; COG5083 272562009074 This domain is found in Saccharomyces cerevisiae protein SMP2, proteins with an N-terminal lipin domain and phosphatidylinositol transfer proteins; Region: LNS2; smart00775 272562009075 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 272562009076 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 272562009077 active site 272562009078 phosphorylation site [posttranslational modification] 272562009079 intermolecular recognition site; other site 272562009080 dimerization interface [polypeptide binding]; other site 272562009081 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 272562009082 DNA binding residues [nucleotide binding] 272562009083 dimerization interface [polypeptide binding]; other site 272562009084 Phospholipid methyltransferase; Region: PEMT; cl17370 272562009085 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: COG4585 272562009086 F0F1 ATP synthase subunit B; Provisional; Region: PRK14471; cl17192 272562009087 Histidine kinase; Region: HisKA_3; pfam07730 272562009088 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 272562009089 ATP binding site [chemical binding]; other site 272562009090 Mg2+ binding site [ion binding]; other site 272562009091 G-X-G motif; other site 272562009092 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 272562009093 haloacid dehalogenase-like hydrolase; Region: Hydrolase_3; pfam08282 272562009094 active site 272562009095 motif I; other site 272562009096 motif II; other site 272562009097 haloacid dehalogenase-like hydrolase; Region: HAD; cl19137 272562009098 S-ribosylhomocysteinase; Provisional; Region: PRK02260 272562009099 Repeat domain in Vibrio, Colwellia, Bradyrhizobium and Shewanella; Region: VCBS; pfam13517 272562009100 Repeat domain in Vibrio, Colwellia, Bradyrhizobium and Shewanella; Region: VCBS; pfam13517 272562009101 Repeat domain in Vibrio, Colwellia, Bradyrhizobium and Shewanella; Region: VCBS; pfam13517 272562009102 Repeat domain in Vibrio, Colwellia, Bradyrhizobium and Shewanella; Region: VCBS; pfam13517 272562009103 Repeat domain in Vibrio, Colwellia, Bradyrhizobium and Shewanella; Region: VCBS; pfam13517 272562009104 Cell wall-associated hydrolases (invasion-associated proteins) [Cell envelope biogenesis, outer membrane]; Region: Spr; COG0791 272562009105 NlpC/P60 family; Region: NLPC_P60; pfam00877 272562009106 Repeat domain in Vibrio, Colwellia, Bradyrhizobium and Shewanella; Region: VCBS; pfam13517 272562009107 Repeat domain in Vibrio, Colwellia, Bradyrhizobium and Shewanella; Region: VCBS; pfam13517 272562009108 Repeat domain in Vibrio, Colwellia, Bradyrhizobium and Shewanella; Region: VCBS; pfam13517 272562009109 Repeat domain in Vibrio, Colwellia, Bradyrhizobium and Shewanella; Region: VCBS; pfam13517 272562009110 Orthopoxvirus protein of unknown function (DUF830); Region: DUF830; cl13998 272562009111 Cell wall-associated hydrolases (invasion-associated proteins) [Cell envelope biogenesis, outer membrane]; Region: Spr; COG0791 272562009112 NlpC/P60 family; Region: NLPC_P60; pfam00877 272562009113 Lactate dehydrogenase and related dehydrogenases [Energy production and conversion / Coenzyme metabolism / General function prediction only]; Region: LdhA; COG1052 272562009114 Putative D-isomer specific 2-hydroxyacid dehydrogenases; Region: 2-Hacid_dh_4; cd12162 272562009115 putative ligand binding site [chemical binding]; other site 272562009116 putative NAD binding site [chemical binding]; other site 272562009117 catalytic site [active] 272562009118 Cupin domain; Region: Cupin_2; cl17218 272562009119 DNA topoisomerase III; Provisional; Region: PRK07726 272562009120 TOPRIM_TopoIA_TopoIII: The topoisomerase-primase (TORPIM) domain found in members of the type IA family of DNA topoisomerases (Topo IA) similar to topoisomerase III. Type IA DNA topoisomerases remove (relax) negative supercoils in the DNA by: cleaving...; Region: TOPRIM_TopoIA_TopoIII; cd03362 272562009121 active site 272562009122 putative interdomain interaction site [polypeptide binding]; other site 272562009123 putative metal-binding site [ion binding]; other site 272562009124 putative nucleotide binding site [chemical binding]; other site 272562009125 DNA Topoisomerase, subtype IA; DNA-binding, ATP-binding and catalytic domain of bacterial DNA topoisomerases I and III, and eukaryotic DNA topoisomerase III and eubacterial and archael reverse gyrases. Topoisomerases clevage single or double stranded DNA...; Region: TOP1Ac; cd00186 272562009126 domain I; other site 272562009127 DNA binding groove [nucleotide binding] 272562009128 phosphate binding site [ion binding]; other site 272562009129 domain II; other site 272562009130 domain III; other site 272562009131 nucleotide binding site [chemical binding]; other site 272562009132 catalytic site [active] 272562009133 domain IV; other site 272562009134 Zn-finger domain associated with topoisomerase type I [DNA replication, recombination, and repair]; Region: TopA; COG0551 272562009135 ABC transporter ATP-binding protein; Provisional; Region: PRK15064 272562009136 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 272562009137 ABC transporter; Region: ABC_tran_2; pfam12848 272562009138 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 272562009139 Predicted permeases [General function prediction only]; Region: COG0679 272562009140 Transcriptional regulators of sugar metabolism [Transcription / Carbohydrate transport and metabolism]; Region: GlpR; COG1349 272562009141 helix_turn_helix, Deoxyribose operon repressor; Region: HTH_DEOR; smart00420 272562009142 DeoR C terminal sensor domain; Region: DeoRC; pfam00455 272562009143 1-phosphofructokinase (FruK), minor 6-phosphofructokinase (pfkB) and related sugar kinases. FruK plays an important role in the predominant pathway for fructose utilisation.This group also contains tagatose-6-phophate kinase, an enzyme of the tagatose...; Region: FruK_PfkB_like; cd01164 272562009144 putative substrate binding site [chemical binding]; other site 272562009145 putative ATP binding site [chemical binding]; other site 272562009146 Tagatose-1,6-bisphosphate (TBP) aldolase and related Type B Class II aldolases. TBP aldolase is a tetrameric class II aldolase that catalyzes the reversible condensation of dihydroxyacetone phosphate with glyceraldehyde 3-phsophate to produce tagatose 1; Region: TBP_aldolase_IIB; cd00947 272562009147 intersubunit interface [polypeptide binding]; other site 272562009148 active site 272562009149 zinc binding site [ion binding]; other site 272562009150 Na+ binding site [ion binding]; other site 272562009151 galactose-6-phosphate isomerase subunit LacB; Reviewed; Region: PRK08622 272562009152 galactose-6-phosphate isomerase subunit LacA; Reviewed; Region: PRK08621 272562009153 Transcriptional regulators of sugar metabolism [Transcription / Carbohydrate transport and metabolism]; Region: GlpR; COG1349 272562009154 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 272562009155 putative DNA binding site [nucleotide binding]; other site 272562009156 putative Zn2+ binding site [ion binding]; other site 272562009157 DeoR C terminal sensor domain; Region: DeoRC; pfam00455 272562009158 Phosphotransferase system, galactitol-specific IIC component [Carbohydrate transport and metabolism]; Region: GatC; COG3775 272562009159 Phosphotransferase system, galactitol-specific IIB component [Carbohydrate transport and metabolism]; Region: SgaB; COG3414 272562009160 active site 272562009161 P-loop; other site 272562009162 phosphorylation site [posttranslational modification] 272562009163 PTS_IIA, PTS system, fructose/mannitol specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_fru; cd00211 272562009164 active site 272562009165 phosphorylation site [posttranslational modification] 272562009166 galactokinase; Provisional; Region: PRK05322 272562009167 Galactokinase galactose-binding signature; Region: GalKase_gal_bdg; pfam10509 272562009168 GHMP kinases N terminal domain; Region: GHMP_kinases_N; pfam00288 272562009169 GHMP kinases C terminal; Region: GHMP_kinases_C; pfam08544 272562009170 UDP-glucose 4-epimerase [Cell envelope biogenesis, outer membrane]; Region: GalE; COG1087 272562009171 UDP-glucose 4 epimerase, subgroup 1, extended (e) SDRs; Region: UDP_G4E_1_SDR_e; cd05247 272562009172 NAD binding site [chemical binding]; other site 272562009173 homodimer interface [polypeptide binding]; other site 272562009174 active site 272562009175 substrate binding site [chemical binding]; other site 272562009176 Galactose-1-phosphate uridyltransferase [Carbohydrate transport and metabolism]; Region: GalT; COG4468 272562009177 Galactose-1-phosphate uridyl transferase, N-terminal domain; Region: GalP_UDP_transf; pfam01087 272562009178 Galactose-1-phosphate uridyl transferase, C-terminal domain; Region: GalP_UDP_tr_C; pfam02744 272562009179 Transcriptional regulators [Transcription]; Region: PurR; COG1609 272562009180 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 272562009181 DNA binding site [nucleotide binding] 272562009182 domain linker motif; other site 272562009183 Ligand binding domain of the LacI tanscriptional regulator family belonging to the type I periplasmic-binding fold protein superfamily; Region: PBP1_LacI_sugar_binding_like; cd06267 272562009184 dimerization interface [polypeptide binding]; other site 272562009185 ligand binding site [chemical binding]; other site 272562009186 6-phospho-beta-galactosidase; Provisional; Region: PRK13511 272562009187 Glycosyl hydrolase family 1; Region: Glyco_hydro_1; pfam00232 272562009188 Phosphotransferase system cellobiose-specific component IIC [Carbohydrate transport and metabolism]; Region: CelB; cl17295 272562009189 PTS_IIB_lactose: subunit IIB of enzyme II (EII) of the lactose-specific phosphoenolpyruvate:carbohydrate phosphotransferase system (PTS) found in Firmicutes as well as Actinobacteria. In this system, EII is a lactose-specific permease with two...; Region: PTS_IIB_lactose; cd05565 272562009190 active site 272562009191 P-loop; other site 272562009192 phosphorylation site [posttranslational modification] 272562009193 PTS_IIA, PTS system, lactose/cellobiose specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_lac; cd00215 272562009194 methionine cluster; other site 272562009195 active site 272562009196 phosphorylation site [posttranslational modification] 272562009197 metal binding site [ion binding]; metal-binding site 272562009198 Transcriptional regulators of sugar metabolism [Transcription / Carbohydrate transport and metabolism]; Region: GlpR; COG1349 272562009199 helix_turn_helix, Deoxyribose operon repressor; Region: HTH_DEOR; smart00420 272562009200 DeoR C terminal sensor domain; Region: DeoRC; pfam00455 272562009201 Alpha-acetolactate decarboxylase [Secondary metabolites biosynthesis, transport, and catabolism]; Region: AlsD; COG3527 272562009202 Mannose-1-phosphate guanylyltransferase [Cell envelope biogenesis, outer membrane]; Region: {ManC}; COG0836 272562009203 GDP-M1P_Guanylyltransferase catalyzes the formation of GDP-Mannose; Region: GDP-M1P_Guanylyltransferase; cd02509 272562009204 Substrate binding site; other site 272562009205 Cupin domain; Region: Cupin_2; cl17218 272562009206 Alkyladenine DNA glycosylase catalyzes the first step in base excision repair; Region: AAG; cd00540 272562009207 active site 272562009208 DNA binding site [nucleotide binding] 272562009209 putative C-S lyase; Region: C_S_lyase_PatB; TIGR04350 272562009210 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 272562009211 pyridoxal 5'-phosphate binding site [chemical binding]; other site 272562009212 homodimer interface [polypeptide binding]; other site 272562009213 catalytic residue [active] 272562009214 thiamine biosynthesis protein ThiI; Provisional; Region: PRK01565 272562009215 THUMP domain of thiamine biosynthesis protein ThiI; Region: THUMP_ThiI; cd11716 272562009216 ThiI is required for thiazole synthesis in the thiamine biosynthesis pathway. It belongs to the Adenosine Nucleotide Hydrolysis suoerfamily and predicted to bind to Adenosine nucleotide; Region: ThiI; cd01712 272562009217 Ligand Binding Site [chemical binding]; other site 272562009218 Cysteine sulfinate desulfinase/cysteine desulfurase and related enzymes [Amino acid transport and metabolism]; Region: NifS; COG1104 272562009219 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 272562009220 catalytic residue [active] 272562009221 KDPG and KHG aldolase; Region: KDPG_aldolase; cd00452 272562009222 Entner-Doudoroff aldolase; Region: eda; TIGR01182 272562009223 active site 272562009224 intersubunit interface [polypeptide binding]; other site 272562009225 catalytic residue [active] 272562009226 putative protease; Provisional; Region: PRK15452 272562009227 Collagenase and related proteases [Posttranslational modification, protein turnover, chaperones]; Region: COG0826 272562009228 aspartyl/glutamyl-tRNA amidotransferase subunit B; Validated; Region: gatB; PRK05477 272562009229 GatB/GatE catalytic domain; Region: GatB_N; pfam02934 272562009230 GatB domain; Region: GatB_Yqey; pfam02637 272562009231 aspartyl/glutamyl-tRNA amidotransferase subunit A; Reviewed; Region: gatA; PRK00012 272562009232 Asp-tRNAAsn/Glu-tRNAGln amidotransferase C subunit [Translation, ribosomal structure and biogenesis]; Region: GatC; COG0721 272562009233 aspartyl-tRNA synthetase; Provisional; Region: aspC; PRK05159 272562009234 Asp_Lys_Asn_RS_N: N-terminal, anticodon recognition domain of class 2b aminoacyl-tRNA synthetases (aaRSs). This domain is a beta-barrel domain (OB fold) involved in binding the tRNA anticodon stem-loop. Class 2b aaRSs include the homodimeric aspartyl-; Region: Asp_Lys_Asn_RS_N; cl19106 272562009235 Dimer interface [polypeptide binding]; other site 272562009236 anticodon binding site; other site 272562009237 Asx tRNA synthetase (AspRS/AsnRS) class II core domain. Assignment to class II aminoacyl-tRNA synthetases (aaRS) based upon its structure and the presence of three characteristic sequence motifs in the core domain. This family includes AsnRS as well as...; Region: AsxRS_core; cd00776 272562009238 homodimer interface [polypeptide binding]; other site 272562009239 motif 1; other site 272562009240 motif 2; other site 272562009241 active site 272562009242 motif 3; other site 272562009243 Nucleoside-diphosphate-sugar pyrophosphorylase involved in lipopolysaccharide biosynthesis/translation initiation factor 2B, gamma/epsilon subunits (eIF-2Bgamma/eIF-2Bepsilon) [Cell envelope biogenesis, outer membrane / Translation, ribosomal structure...; Region: GCD1; COG1208 272562009244 NTP_transferases catalyze the transfer of nucleotides onto phosphosugars; Region: NTP_transferase; cd04181 272562009245 active site 272562009246 Substrate binding site; other site 272562009247 Mg++ binding site; other site 272562009248 Bacterial transferase hexapeptide (six repeats); Region: Hexapep; pfam00132 272562009249 Left-handed parallel beta-Helix (LbetaH or LbH) domain: The alignment contains 5 turns, each containing three imperfect tandem repeats of a hexapeptide repeat motif (X-[STAV]-X-[LIV]-[GAED]-X). Proteins containing hexapeptide repeats are often enzymes...; Region: LbetaH; cl00160 272562009250 putative trimer interface [polypeptide binding]; other site 272562009251 putative CoA binding site [chemical binding]; other site 272562009252 Phosphomannomutase [Carbohydrate transport and metabolism]; Region: {ManB}; COG1109 272562009253 The alpha-D-phosphohexomutase superfamily includes several related enzymes that catalyze a reversible intramolecular phosphoryl transfer on their sugar substrates. Members of this family include the phosphoglucomutases (PGM1 and PGM2), phosphoglucosamine...; Region: phosphohexomutase; cl03757 272562009254 active site 272562009255 substrate binding site [chemical binding]; other site 272562009256 metal binding site [ion binding]; metal-binding site 272562009257 ATPases involved in chromosome partitioning [Cell division and chromosome partitioning]; Region: Soj; COG1192 272562009258 MRP (Multiple Resistance and pH adaptation) is a homologue of the Fer4_NifH superfamily. Like the other members of the superfamily, MRP contains a ATP-binding domain at the N-termini. It is found in bacteria as a membrane-spanning protein and functions...; Region: MRP-like; cd02037 272562009259 Walker A motif; other site 272562009260 phosphodiesterase; Provisional; Region: PRK12704 272562009261 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 272562009262 S-adenosylmethionine binding site [chemical binding]; other site 272562009263 ribonuclease M5; Region: 5S_RNA_mat_M5; TIGR00334 272562009264 TOPRIM_ RNase M5_like: The topoisomerase-primase (TOPRIM) nucleotidyl transferase/hydrolase domain found in Ribonuclease M5: (RNase M5) and other small primase-like proteins from bacteria and archaea. RNase M5 catalyzes the maturation of 5S rRNA in low...; Region: TOPRIM_RNase_M5_like; cd01027 272562009265 putative active site [active] 272562009266 putative metal binding site [ion binding]; other site 272562009267 Domain of unknown function (DUF4093); Region: DUF4093; pfam13331 272562009268 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3583 272562009269 Domain of unknown function (DUF348); Region: DUF348; pfam03990 272562009270 Domain of unknown function (DUF348); Region: DUF348; pfam03990 272562009271 G5 domain; Region: G5; pfam07501 272562009272 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3584 272562009273 TatD like proteins; E.coli TatD is a cytoplasmic protein, shown to have magnesium dependent DNase activity; Region: TatD_DNAse; cd01310 272562009274 active site 272562009275 Cold-Shock Protein (CSP) contains an S1-like cold-shock domain (CSD) that is found in eukaryotes, prokaryotes, and archaea. CSP's include the major cold-shock proteins CspA and CspB in bacteria and the eukaryotic gene regulatory factor Y-box...; Region: CSP_CDS; cd04458 272562009276 DNA-binding site [nucleotide binding]; DNA binding site 272562009277 RNA-binding motif; other site 272562009278 methionyl-tRNA synthetase; Reviewed; Region: PRK12267 272562009279 catalytic core domain of methioninyl-tRNA synthetases; Region: MetRS_core; cd00814 272562009280 active site 272562009281 HIGH motif; other site 272562009282 KMSKS motif; other site 272562009283 Anticodon-binding domain of methionyl tRNA synthetases; Region: Anticodon_Ia_Met; cd07957 272562009284 tRNA binding surface [nucleotide binding]; other site 272562009285 anticodon binding site; other site 272562009286 tRNA-binding-domain-containing Escherichia coli methionyl-tRNA synthetase (EcMetRS)-like proteins. This family includes EcMetRS and Aquifex aeolicus Trbp111 (AaTrbp111). This domain has general tRNA binding properties. MetRS aminoacylates methionine...; Region: tRNA_bind_EcMetRS_like; cd02800 272562009287 dimer interface [polypeptide binding]; other site 272562009288 putative tRNA-binding site [nucleotide binding]; other site 272562009289 Short-chain dehydrogenases of various substrate specificities [General function prediction only]; Region: DltE; COG0300 272562009290 classical (c) SDRs; Region: SDR_c; cd05233 272562009291 NAD(P) binding site [chemical binding]; other site 272562009292 active site 272562009293 Domain of unknown function (DUF4356); Region: DUF4356; pfam14266 272562009294 Uncharacterized protein involved in tellurite resistance [Inorganic ion transport and metabolism]; Region: TelA; COG3853 272562009295 Toxic anion resistance protein (TelA); Region: TelA; pfam05816 272562009296 Phosphotransferase system IIA components [Carbohydrate transport and metabolism]; Region: NagE; COG2190 272562009297 HPr interaction site; other site 272562009298 glycerol kinase (GK) interaction site [polypeptide binding]; other site 272562009299 active site 272562009300 phosphorylation site [posttranslational modification] 272562009301 Bacterial SNF2 helicase associated; Region: SNF2_assoc; pfam08455 272562009302 SNF2 family N-terminal domain; Region: SNF2_N; pfam00176 272562009303 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 272562009304 ATP binding site [chemical binding]; other site 272562009305 putative Mg++ binding site [ion binding]; other site 272562009306 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 272562009307 nucleotide binding region [chemical binding]; other site 272562009308 ATP-binding site [chemical binding]; other site 272562009309 Family 4 Uracil-DNA glycosylase (UDG), found exclusively in thermophilic organisms; Region: UDG_F4_TTUDGA_like; cd10030 272562009310 Fe-S cluster binding site [ion binding]; other site 272562009311 active site 272562009312 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 272562009313 binding surface 272562009314 TPR repeat; Region: TPR_11; pfam13414 272562009315 TPR motif; other site 272562009316 TPR repeat; Region: TPR_11; pfam13414 272562009317 TPR repeat; Region: TPR_11; pfam13414 272562009318 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 272562009319 binding surface 272562009320 TPR motif; other site 272562009321 TPR repeat; Region: TPR_11; pfam13414 272562009322 TPR repeat; Region: TPR_11; pfam13414 272562009323 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 272562009324 binding surface 272562009325 TPR motif; other site 272562009326 TPR repeat; Region: TPR_11; pfam13414 272562009327 Tetratricopeptide repeat; Region: TPR_12; pfam13424 272562009328 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3877 272562009329 Ferritin-like superfamily of diiron-containing four-helix-bundle proteins; Region: Ferritin_like; cd00657 272562009330 dinuclear metal binding motif [ion binding]; other site 272562009331 Thymidylate synthase and pyrimidine hydroxymethylase: Thymidylate synthase (TS) and deoxycytidylate hydroxymethylase (dCMP-HMase) are homologs that catalyze analogous alkylation of C5 of pyrimidine nucleotides. Both enzymes are involved in the...; Region: TS_Pyrimidine_HMase; cd00351 272562009332 dimerization interface [polypeptide binding]; other site 272562009333 active site 272562009334 Dihydrofolate reductase (DHFR). Reduces 7,8-dihydrofolate to 5,6,7,8-tetrahydrofolate with NADPH as a cofactor. This is an essential step in the biosynthesis of deoxythymidine phosphate since 5,6,7,8-tetrahydrofolate is required to regenerate 5; Region: DHFR; cd00209 272562009335 folate binding site [chemical binding]; other site 272562009336 NADP+ binding site [chemical binding]; other site 272562009337 Adenosine deaminase (ADA) is a monomeric zinc dependent enzyme which catalyzes the irreversible hydrolytic deamination of both adenosine, as well as desoxyadenosine, to ammonia and inosine or desoxyinosine, respectively. ADA plays an important role in...; Region: ADA; cd01320 272562009338 active site 272562009339 purine riboside binding site [chemical binding]; other site 272562009340 Predicted Zn-dependent peptidases, insulinase-like [General function prediction only]; Region: COG1026 272562009341 Insulinase (Peptidase family M16); Region: Peptidase_M16; pfam00675 272562009342 Peptidase M16 inactive domain; Region: Peptidase_M16_C; pfam05193 272562009343 Peptidase M16C associated; Region: M16C_assoc; pfam08367 272562009344 Peptidase M16 inactive domain; Region: Peptidase_M16_C; pfam05193 272562009345 ATPase components of ABC transporters with duplicated ATPase domains [General function prediction only]; Region: Uup; COG0488 272562009346 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 272562009347 ABC transporter; Region: ABC_tran_2; pfam12848 272562009348 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 272562009349 FOG: CBS domain [General function prediction only]; Region: COG0517 272562009350 The CBS domain, named after human CBS, is a small domain originally identified in cystathionine beta-synthase and is subsequently found in a wide range of different proteins. CBS domains usually occur in tandem repeats. They associate to form a so-called...; Region: CBS_pair_30; cd04643 272562009351 Catalytic NodB homology domain of Bacillus subtilis polysaccharide deacetylase PdaA, and its bacterial homologs; Region: CE4_BsPdaA_like; cd10948 272562009352 delta-lactam-biosynthetic de-N-acetylase; Region: spore_pdaA; TIGR02884 272562009353 NodB motif; other site 272562009354 active site 272562009355 catalytic site [active] 272562009356 Cd binding site [ion binding]; other site 272562009357 Superfamily II DNA and RNA helicases [DNA replication, recombination, and repair / Transcription / Translation, ribosomal structure and biogenesis]; Region: SrmB; COG0513 272562009358 DEAD-box helicases. A diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker B motif; Region: DEADc; cd00268 272562009359 ATP binding site [chemical binding]; other site 272562009360 Mg++ binding site [ion binding]; other site 272562009361 motif III; other site 272562009362 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 272562009363 nucleotide binding region [chemical binding]; other site 272562009364 ATP-binding site [chemical binding]; other site 272562009365 RNA recognition motif in the DbpA subfamily of prokaryotic DEAD-box rRNA helicases; Region: RRM_DbpA; cd12252 272562009366 RNA binding site [nucleotide binding]; other site 272562009367 ATPase components of ABC transporters with duplicated ATPase domains [General function prediction only]; Region: Uup; COG0488 272562009368 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 272562009369 ABC transporter; Region: ABC_tran_2; pfam12848 272562009370 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 272562009371 Uncharacterized conserved protein [Function unknown]; Region: COG5482 272562009372 thiamine biosynthesis protein ThiC; Provisional; Region: PRK13352 272562009373 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 272562009374 Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013 272562009375 Predicted integral membrane protein [Function unknown]; Region: COG0392 272562009376 Predicted xylanase/chitin deacetylase [Carbohydrate transport and metabolism]; Region: CDA1; COG0726 272562009377 Catalytic NodB homology domain of Streptococcus mutans polysaccharide deacetylase PgdA, Bacillus subtilis YheN, and similar proteins; Region: CE4_SmPgdA_like; cd10944 272562009378 NodB motif; other site 272562009379 active site 272562009380 catalytic site [active] 272562009381 Zn binding site [ion binding]; other site 272562009382 Rubrerythrin [Energy production and conversion]; Region: COG1592 272562009383 Rubrerythrin, ferritin-like diiron-binding domain; Region: Rubrerythrin; cd01041 272562009384 binuclear metal center [ion binding]; other site 272562009385 Rubredoxin, Small Modular nonheme iron binding domain containing a [Fe(SCys)4] center, present in rubrerythrin and nigerythrin and detected either N- or C-terminal to such proteins as flavin reductase, NAD(P)H-nitrite reductase, and...; Region: rubredoxin_SM; cd00729 272562009386 iron binding site [ion binding]; other site 272562009387 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 272562009388 metal binding site [ion binding]; metal-binding site 272562009389 active site 272562009390 I-site; other site 272562009391 EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2). The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948 272562009392 Ornithine acetyltransferase (OAT) family; also referred to as ArgJ. OAT catalyzes the first and fifth steps in arginine biosynthesis, coupling acetylation of glutamate with deacetylation of N-acetylornithine, which allows recycling of the acetyl group in...; Region: OAT; cd02152 272562009393 heterotetramer interface [polypeptide binding]; other site 272562009394 active site pocket [active] 272562009395 cleavage site 272562009396 Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067 272562009397 catalytic core [active] 272562009398 Alpha/beta hydrolase family; Region: Abhydrolase_5; pfam12695 272562009399 Prolyl oligopeptidase family; Region: Peptidase_S9; cl19144 272562009400 Members of the SGNH-hydrolase superfamily, a diverse family of lipases and esterases. The tertiary fold of the enzyme is substantially different from that of the alpha/beta hydrolase family and unique among all known hydrolases; its active site closely...; Region: SGNH_hydrolase_YpmR_like; cd04506 272562009401 active site 272562009402 catalytic triad [active] 272562009403 oxyanion hole [active] 272562009404 ABC-type transport system involved in multi-copper enzyme maturation, permease component [General function prediction only]; Region: NosY; COG1277 272562009405 ABC-type multidrug transport system, ATPase component [Defense mechanisms]; Region: CcmA; COG1131 272562009406 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 272562009407 Walker A/P-loop; other site 272562009408 ATP binding site [chemical binding]; other site 272562009409 Q-loop/lid; other site 272562009410 ABC transporter signature motif; other site 272562009411 Walker B; other site 272562009412 D-loop; other site 272562009413 H-loop/switch region; other site 272562009414 Bacillus subtilis YkuE and related proteins, C-terminal metallophosphatase domain; Region: MPP_YkuE_C; cd07385 272562009415 Predicted phosphohydrolases [General function prediction only]; Region: Icc; COG1409 272562009416 putative active site [active] 272562009417 putative metal binding site [ion binding]; other site 272562009418 CAAX protease self-immunity; Region: Abi; pfam02517 272562009419 Polysaccharide pyruvyl transferase; Region: PS_pyruv_trans; pfam04230 272562009420 histidinol-phosphate aminotransferase; Provisional; Region: PRK05387 272562009421 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 272562009422 pyridoxal 5'-phosphate binding site [chemical binding]; other site 272562009423 homodimer interface [polypeptide binding]; other site 272562009424 catalytic residue [active] 272562009425 Aldose 1-epimerase, similar to Lactococcus lactis lacX; Region: Aldose_epim_lacX; cd09024 272562009426 active site 272562009427 catalytic residues [active] 272562009428 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3883 272562009429 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3584 272562009430 Mismatch repair ATPase (MutS family) [DNA replication, recombination, and repair]; Region: MutS; COG0249 272562009431 MutS domain III; Region: MutS_III; pfam05192 272562009432 ATP-binding cassette domain of MutS-like homolog; Region: ABC_MutS-like; cd03283 272562009433 Walker A/P-loop; other site 272562009434 ATP binding site [chemical binding]; other site 272562009435 Q-loop/lid; other site 272562009436 ABC transporter signature motif; other site 272562009437 Walker B; other site 272562009438 D-loop; other site 272562009439 H-loop/switch region; other site 272562009440 Predicted hydrolases of the HAD superfamily [General function prediction only]; Region: Cof; COG0561 272562009441 haloacid dehalogenase-like hydrolase; Region: HAD; cl19137 272562009442 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 272562009443 active site 272562009444 motif I; other site 272562009445 motif II; other site 272562009446 Superfamily I DNA and RNA helicases and helicase subunits [DNA replication, recombination, and repair]; Region: COG1112 272562009447 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 272562009448 The Fer4_NifH superfamily contains a variety of proteins which share a common ATP-binding domain. Functionally, proteins in this superfamily use the energy from hydrolysis of NTP to transfer electron or ion; Region: Fer4_NifH; cd01983 272562009449 ATP binding site [chemical binding]; other site 272562009450 AAA domain; Region: AAA_12; pfam13087 272562009451 Superfamily of nucleases including Short Patch Repair (Vsr) Endonucleases, archaeal Holliday junction resolvases, MutH methy-directed DNA mismatch-repair endonucleases, and catalytic domains of many restriction endonucleases, such as EcoRI, BamHI, and...; Region: Restriction_endonuclease_like; cl00277 272562009452 putative active site [active] 272562009453 Transcriptional regulators [Transcription]; Region: PurR; COG1609 272562009454 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 272562009455 DNA binding site [nucleotide binding] 272562009456 domain linker motif; other site 272562009457 Ligand binding domain of the LacI tanscriptional regulator family belonging to the type I periplasmic-binding fold protein superfamily; Region: PBP1_LacI_sugar_binding_like; cd06267 272562009458 dimerization interface [polypeptide binding]; other site 272562009459 ligand binding site [chemical binding]; other site 272562009460 isoleucyl-tRNA synthetase; Reviewed; Region: ileS; PRK06039 272562009461 catalytic core domain of isoleucyl-tRNA synthetases; Region: IleRS_core; cd00818 272562009462 active site 272562009463 HIGH motif; other site 272562009464 KMSKS motif; other site 272562009465 Anticodon-binding domain of archaeal, bacterial, and eukaryotic cytoplasmic isoleucyl tRNA synthetases; Region: Anticodon_Ia_Ile_ABEc; cd07961 272562009466 tRNA binding surface [nucleotide binding]; other site 272562009467 anticodon binding site; other site 272562009468 tol-pal system beta propeller repeat protein TolB; Region: propeller_TolB; TIGR02800 272562009469 capsular exopolysaccharide family; Region: eps_fam; TIGR01007 272562009470 AAA domain; Region: AAA_31; pfam13614 272562009471 Fucose 4-O-acetylase and related acetyltransferases [Carbohydrate transport and metabolism]; Region: NolL; COG3594 272562009472 Fucose 4-O-acetylase and related acetyltransferases [Carbohydrate transport and metabolism]; Region: NolL; COG3594 272562009473 capsular exopolysaccharide family; Region: eps_fam; TIGR01007 272562009474 AAA domain; Region: AAA_31; pfam13614 272562009475 Capsular polysaccharide biosynthesis protein [Cell envelope biogenesis, outer membrane]; Region: COG3944 272562009476 Chain length determinant protein; Region: Wzz; pfam02706 272562009477 G-rich domain on putative tyrosine kinase; Region: GNVR; pfam13807 272562009478 Capsular polysaccharide biosynthesis protein [Carbohydrate transport and metabolism / Cell envelope biogenesis, outer membrane]; Region: CapC; COG4464 272562009479 PHP domain; Region: PHP; pfam02811 272562009480 Transcriptional regulator [Transcription]; Region: LytR; COG1316 272562009481 integral membrane protein MviN; Region: mviN; TIGR01695 272562009482 MurJ/MviN, a subfamily of the multidrug and toxic compound extrusion (MATE)-like proteins; Region: MATE_MurJ_like; cd13123 272562009483 O-Antigen ligase; Region: Wzy_C; pfam04932 272562009484 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 272562009485 This family is most closely related to the GT1 family of glycosyltransferases and named after YqgM in Bacillus licheniformis about which little is known. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to...; Region: GT1_YqgM_like; cd03801 272562009486 Polysaccharide pyruvyl transferase family protein [Cell wall/membrane/envelope biogenesis]; Region: WcaK; COG2327 272562009487 Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013 272562009488 sugar transferase, PEP-CTERM/EpsH1 system associated; Region: stp1; TIGR03087 272562009489 This family is most closely related to the GT1 family of glycosyltransferases and named after YqgM in Bacillus licheniformis about which little is known. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to...; Region: GT1_YqgM_like; cd03801 272562009490 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 272562009491 Histidinol phosphatase and related phosphatases [Amino acid transport and metabolism]; Region: HisB; COG0241 272562009492 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 272562009493 active site 272562009494 motif I; other site 272562009495 motif II; other site 272562009496 Phosphoheptose isomerase is a member of the SIS (Sugar ISomerase) superfamily. Phosphoheptose isomerase catalyzes the isomerization of sedoheptulose 7-phosphate into D-glycero-D-mannoheptose 7-phosphate. This is the first step of the biosynthesis of...; Region: SIS_GmhA; cd05006 272562009497 dimer interface [polypeptide binding]; other site 272562009498 active site 272562009499 Predicted kinase related to galactokinase and mevalonate kinase [General function prediction only]; Region: COG2605 272562009500 GHMP kinases N terminal domain; Region: GHMP_kinases_N; pfam00288 272562009501 Nucleoside-diphosphate-sugar pyrophosphorylase involved in lipopolysaccharide biosynthesis/translation initiation factor 2B, gamma/epsilon subunits (eIF-2Bgamma/eIF-2Bepsilon) [Cell envelope biogenesis, outer membrane / Translation, ribosomal structure...; Region: GCD1; COG1208 272562009502 WcbM_like is a subfamily of nucleotidyl transferases; Region: NTP_transferase_WcbM_like; cd06915 272562009503 Substrate binding site; other site 272562009504 Mg++ binding site; other site 272562009505 metal-binding site 272562009506 Mg++ binding site; other site 272562009507 metal-binding site 272562009508 sugar transferase, PEP-CTERM/EpsH1 system associated; Region: stp1; TIGR03087 272562009509 Glycosyl transferases group 1; Region: Glyco_trans_1_4; pfam13692 272562009510 Mannose-1-phosphate guanylyltransferase [Cell envelope biogenesis, outer membrane]; Region: {ManC}; COG0836 272562009511 GDP-M1P_Guanylyltransferase catalyzes the formation of GDP-Mannose; Region: GDP-M1P_Guanylyltransferase; cd02509 272562009512 Substrate binding site; other site 272562009513 Bacterial sugar transferase; Region: Bac_transf; pfam02397 272562009514 capsular exopolysaccharide family; Region: eps_fam; TIGR01007 272562009515 AAA domain; Region: AAA_31; pfam13614 272562009516 Capsular polysaccharide biosynthesis protein [Cell envelope biogenesis, outer membrane]; Region: COG3944 272562009517 Chain length determinant protein; Region: Wzz; pfam02706 272562009518 G-rich domain on putative tyrosine kinase; Region: GNVR; pfam13807 272562009519 Capsular polysaccharide biosynthesis protein [Carbohydrate transport and metabolism / Cell envelope biogenesis, outer membrane]; Region: CapC; COG4464 272562009520 PHP domain; Region: PHP; pfam02811 272562009521 Transcriptional regulator [Transcription]; Region: LytR; COG1316 272562009522 UDP-N-acetylglucosamine 2-epimerase [Cell envelope biogenesis, outer membrane]; Region: WecB; COG0381 272562009523 Bacterial members of the UDP-N-Acetylglucosamine (GlcNAc) 2-Epimerase family are known to catalyze the reversible interconversion of UDP-GlcNAc and UDP-N-acetylmannosamine (UDP-ManNAc). The enzyme serves to produce an activated form of ManNAc residues; Region: GT1_UDP-GlcNAc_2-Epimerase; cd03786 272562009524 active site 272562009525 homodimer interface [polypeptide binding]; other site 272562009526 Membrane protein involved in the export of O-antigen and teichoic acid [General function prediction only]; Region: RfbX; COG2244 272562009527 Wzx, a subfamily of the multidrug and toxic compound extrusion (MATE)-like proteins; Region: MATE_Wzx_like; cd13128 272562009528 Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013 272562009529 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 272562009530 O-antigen ligase like membrane protein; Region: O-antigen_lig; cl04850 272562009531 O-Antigen ligase; Region: Wzy_C; pfam04932 272562009532 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 272562009533 Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013 272562009534 Predicted glycosyltransferases [General function prediction only]; Region: COG1216 272562009535 Subfamily of Glycosyltransferase Family GT2 of unknown function; Region: GT_2_like_c; cd04186 272562009536 Probable Catalytic site; other site 272562009537 metal-binding site 272562009538 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 272562009539 This family is most closely related to the GT1 family of glycosyltransferases. mtfB (mannosyltransferase B) in E. coli has been shown to direct the growth of the O9-specific polysaccharide chain. It transfers two mannoses into the position 3 of the...; Region: GT1_mtfB_like; cd03809 272562009540 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 272562009541 This family is most closely related to the GT1 family of glycosyltransferases. wbaZ in Salmonella enterica has been shown to possess the mannosyl transferase activity. The members of this family are found in certain bacteria and Archaea; Region: GT1_wbaZ_like; cd03804 272562009542 putative ADP-binding pocket [chemical binding]; other site 272562009543 Mannose-1-phosphate guanylyltransferase [Cell envelope biogenesis, outer membrane]; Region: {ManC}; COG0836 272562009544 GDP-M1P_Guanylyltransferase catalyzes the formation of GDP-Mannose; Region: GDP-M1P_Guanylyltransferase; cd02509 272562009545 Substrate binding site; other site 272562009546 Bacterial sugar transferase; Region: Bac_transf; pfam02397 272562009547 Predicted integral membrane protein [Function unknown]; Region: COG5652 272562009548 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cd00012 272562009549 nucleotide binding site [chemical binding]; other site 272562009550 Acetokinase family; Region: Acetate_kinase; cl17229 272562009551 phosphate butyryltransferase; Validated; Region: PRK05805 272562009552 Uncharacterized FAD-dependent dehydrogenases [General function prediction only]; Region: COG2509 272562009553 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4856 272562009554 YbbR-like protein; Region: YbbR; pfam07949 272562009555 Uncharacterized conserved protein [Function unknown]; Region: COG1624 272562009556 DisA bacterial checkpoint controller nucleotide-binding; Region: DisA_N; pfam02457 272562009557 Cell wall hydrolyses involved in spore germination [Cell envelope biogenesis, outer membrane]; Region: SleB; COG3773 272562009558 Cell Wall Hydrolase; Region: Hydrolase_2; pfam07486 272562009559 Thioredoxin reductase [Posttranslational modification, protein turnover, chaperones]; Region: TrxB; COG0492 272562009560 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl19134 272562009561 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl19134 272562009562 TRX family; composed of two groups: Group I, which includes proteins that exclusively encode a TRX domain; and Group II, which are composed of fusion proteins of TRX and additional domains. Group I TRX is a small ancient protein that alter the redox...; Region: TRX_family; cd02947 272562009563 catalytic residues [active] 272562009564 Phosphoglycerate kinase (PGK) is a monomeric enzyme which catalyzes the transfer of the high-energy phosphate group of 1,3-bisphosphoglycerate to ADP, forming ATP and 3-phosphoglycerate. This reaction represents the first of the two substrate-level...; Region: Phosphoglycerate_kinase; cl00198 272562009565 tol-pal system protein YbgF; Region: tol_pal_ybgF; TIGR02795 272562009566 Bacterial surface proteins containing Ig-like domains [Cell motility and secretion]; Region: COG5492 272562009567 Bacterial Ig-like domain (group 2); Region: Big_2; pfam02368 272562009568 Phosphoenolpyruvate-protein kinase (PTS system EI component in bacteria) [Carbohydrate transport and metabolism]; Region: PtsA; COG1080 272562009569 PEP-utilizing enzyme, N-terminal; Region: PEP-utilizers_N; pfam05524 272562009570 PEP-utilizing enzyme, mobile domain; Region: PEP-utilizers; pfam00391 272562009571 PEP-utilizing enzyme, TIM barrel domain; Region: PEP-utilizers_C; pfam02896 272562009572 Histidine-containing phosphocarrier protein (HPr)-like proteins. HPr is a central component of the bacterial phosphoenolpyruvate sugar phosphotransferase system (PTS). The PTS catalyses the phosphorylation of sugar substrates during their translocation...; Region: PTS-HPr_like; cd00367 272562009573 dimerization domain swap beta strand [polypeptide binding]; other site 272562009574 regulatory protein interface [polypeptide binding]; other site 272562009575 active site 272562009576 regulatory phosphorylation site [posttranslational modification]; other site 272562009577 Transcriptional regulator containing PAS, AAA-type ATPase, and DNA-binding domains [Transcription / Signal transduction mechanisms]; Region: RocR; COG3829 272562009578 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 272562009579 putative active site [active] 272562009580 heme pocket [chemical binding]; other site 272562009581 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 272562009582 putative active site [active] 272562009583 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 272562009584 Walker A motif; other site 272562009585 ATP binding site [chemical binding]; other site 272562009586 Walker B motif; other site 272562009587 arginine finger; other site 272562009588 fumarate hydratase; Provisional; Region: PRK06842 272562009589 fumarate hydratase; Provisional; Region: PRK06246 272562009590 N-acetylmuramoyl-L-alanine amidase [Cell envelope biogenesis, outer membrane]; Region: AmiC; COG0860 272562009591 N-acetylmuramoyl-L-alanine amidase or MurNAc-LAA (also known as peptidoglycan aminohydrolase, NAMLA amidase, NAMLAA, Amidase 3, and peptidoglycan amidase; EC 3.5.1.28) is an autolysin that hydrolyzes the amide bond between N-acetylmuramoyl and L-amino...; Region: MurNAc-LAA; cd02696 272562009592 active site 272562009593 metal binding site [ion binding]; metal-binding site 272562009594 Phosphate transporter family; Region: PHO4; pfam01384 272562009595 Phosphate transport regulator (distant homolog of PhoU) [Inorganic ion transport and metabolism]; Region: COG1392 272562009596 TIGR00153 family protein; Region: TIGR00153 272562009597 4-amino-5-hydroxymethyl-2-methyl-pyrimidine phosphate kinase (HMPP-kinase) catalyzes two consecutive phosphorylation steps in the thiamine phosphate biosynthesis pathway, leading to the synthesis of vitamin B1. The first step is the phosphorylation of...; Region: HMPP_kinase; cd01169 272562009598 dimer interface [polypeptide binding]; other site 272562009599 substrate binding site [chemical binding]; other site 272562009600 ATP binding site [chemical binding]; other site 272562009601 4-methyl-5-beta-hydroxyethylthiazole (Thz) kinase catalyzes the phosphorylation of the hydroxylgroup of Thz. A reaction that allows cells to recycle Thz into the thiamine biosynthesis pathway, as an alternative to its synthesis from cysteine, tyrosine...; Region: THZ_kinase; cd01170 272562009602 substrate binding site [chemical binding]; other site 272562009603 multimerization interface [polypeptide binding]; other site 272562009604 ATP binding site [chemical binding]; other site 272562009605 30S ribosomal protein S9; Reviewed; Region: rpsI; PRK00132 272562009606 Ribosomal protein L13. Protein L13, a large ribosomal subunit protein, is one of five proteins required for an early folding intermediate of 23S rRNA in the assembly of the large subunit. L13 is situated on the bottom of the large subunit, near the...; Region: Ribosomal_L13; cd00392 272562009607 23S rRNA interface [nucleotide binding]; other site 272562009608 L3 interface [polypeptide binding]; other site 272562009609 tRNA pseudouridine synthase A; Validated; Region: truA; PRK00021 272562009610 Eukaryotic and bacterial pseudouridine synthases similar to E. coli TruA; Region: PseudoU_synth_EcTruA; cd02570 272562009611 dimerization interface 3.5A [polypeptide binding]; other site 272562009612 active site 272562009613 ABC-type cobalt transport system, permease component CbiQ and related transporters [Inorganic ion transport and metabolism]; Region: CbiQ; COG0619 272562009614 cobalt transporter ATP-binding subunit; Provisional; Region: cbiO; PRK13637 272562009615 First domain of the ATP-binding cassette component of cobalt transport system; Region: ABC_cobalt_CbiO_domain1; cd03225 272562009616 Walker A/P-loop; other site 272562009617 ATP binding site [chemical binding]; other site 272562009618 Q-loop/lid; other site 272562009619 ABC transporter signature motif; other site 272562009620 Walker B; other site 272562009621 D-loop; other site 272562009622 H-loop/switch region; other site 272562009623 cobalt transporter ATP-binding subunit; Provisional; Region: PRK13633 272562009624 First domain of the ATP-binding cassette component of cobalt transport system; Region: ABC_cobalt_CbiO_domain1; cd03225 272562009625 Walker A/P-loop; other site 272562009626 ATP binding site [chemical binding]; other site 272562009627 Q-loop/lid; other site 272562009628 ABC transporter signature motif; other site 272562009629 Walker B; other site 272562009630 D-loop; other site 272562009631 H-loop/switch region; other site 272562009632 50S ribosomal protein L17; Validated; Region: rplQ; PRK05591 272562009633 DNA-directed RNA polymerase subunit alpha; Provisional; Region: PRK05182 272562009634 N-terminal domain of the Alpha subunit of Bacterial RNA polymerase; Region: RNAP_alpha_NTD; cd06928 272562009635 alphaNTD homodimer interface [polypeptide binding]; other site 272562009636 alphaNTD - beta interaction site [polypeptide binding]; other site 272562009637 alphaNTD - beta' interaction site [polypeptide binding]; other site 272562009638 Bacterial RNA polymerase, alpha chain C terminal domain; Region: RNA_pol_A_CTD; pfam03118 272562009639 30S ribosomal protein S4; Validated; Region: rpsD; PRK05327 272562009640 Ribosomal protein S4/S9 N-terminal domain; Region: Ribosomal_S4; pfam00163 272562009641 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 272562009642 RNA binding surface [nucleotide binding]; other site 272562009643 30S ribosomal protein S11; Validated; Region: PRK05309 272562009644 30S ribosomal protein S13; Validated; Region: rpsM; PRK05179 272562009645 50S ribosomal protein L36; Reviewed; Region: rpmJ; PRK00465 272562009646 S1_IF1: Translation Initiation Factor IF1, S1-like RNA-binding domain. IF1 contains an S1-like RNA-binding domain, which is found in a wide variety of RNA-associated proteins. Translation initiation includes a number of interrelated steps preceding the...; Region: S1_IF1; cd04451 272562009647 rRNA binding site [nucleotide binding]; other site 272562009648 predicted 30S ribosome binding site; other site 272562009649 KOW motif of Ribosomal Protein L14; Region: KOW_RPL14; cd06088 272562009650 RNA binding site [nucleotide binding]; other site 272562009651 Methionine Aminopeptidase 1. E.C. 3.4.11.18. Also known as methionyl aminopeptidase and Peptidase M. Catalyzes release of N-terminal amino acids, preferentially methionine, from peptides and arylamides; Region: MetAP1; cd01086 272562009652 active site 272562009653 adenylate kinase; Reviewed; Region: adk; PRK00279 272562009654 Adenylate kinase (ADK) catalyzes the reversible phosphoryl transfer from adenosine triphosphates (ATP) to adenosine monophosphates (AMP) and to yield adenosine diphosphates (ADP). This enzyme is required for the biosynthesis of ADP and is essential for...; Region: ADK; cd01428 272562009655 AMP-binding site [chemical binding]; other site 272562009656 ATP-AMP (Ap5A)-binding site [chemical binding]; other site 272562009657 preprotein translocase subunit SecY; Reviewed; Region: secY; PRK09204 272562009658 SecY translocase; Region: SecY; pfam00344 272562009659 50S ribosomal protein L15; Reviewed; Region: rplO; PRK05592 272562009660 Ribosomal protein L30, which is found in eukaryotes and prokaryotes but not in archaea, is one of the smallest ribosomal proteins with a molecular mass of about 7kDa. L30 binds the 23SrRNA as well as the 5S rRNA and is one of five ribosomal proteins that...; Region: Ribosomal_L30; cd01658 272562009661 23S rRNA binding site [nucleotide binding]; other site 272562009662 30S ribosomal protein S5; Validated; Region: rpsE; PRK00550 272562009663 Ribosomal protein S5, N-terminal domain; Region: Ribosomal_S5; pfam00333 272562009664 Ribosomal protein S5, C-terminal domain; Region: Ribosomal_S5_C; pfam03719 272562009665 Ribosomal L18/L5e: L18 (L5e) is a ribosomal protein found in the central protuberance (CP) of the large subunit. L18 binds 5S rRNA and induces a conformational change that stimulates the binding of L5 to 5S rRNA. Association of 5S rRNA with 23S rRNA...; Region: Ribosomal_L18_L5e; cd00432 272562009666 5S rRNA interface [nucleotide binding]; other site 272562009667 L27 interface [polypeptide binding]; other site 272562009668 23S rRNA interface [nucleotide binding]; other site 272562009669 L5 interface [polypeptide binding]; other site 272562009670 50S ribosomal protein L6; Validated; Region: rplF; PRK05498 272562009671 Ribosomal protein L6; Region: Ribosomal_L6; pfam00347 272562009672 Ribosomal protein L6; Region: Ribosomal_L6; pfam00347 272562009673 30S ribosomal protein S8; Validated; Region: rpsH; PRK00136 272562009674 30S ribosomal protein S14; Reviewed; Region: rpsN; PRK08061 272562009675 50S ribosomal protein L5; Validated; Region: rplE; PRK00010 272562009676 Ribosomal protein L5; Region: Ribosomal_L5; pfam00281 272562009677 ribosomal L5P family C-terminus; Region: Ribosomal_L5_C; pfam00673 272562009678 KOW motif of Ribosomal Protein L26; Region: KOW_RPL26; cd06089 272562009679 RNA binding site [nucleotide binding]; other site 272562009680 50S ribosomal protein L14; Validated; Region: rplN; PRK05483 272562009681 30S ribosomal protein S17; Reviewed; Region: rpsQ; PRK05610 272562009682 Ribosomal L29 protein/HIP. L29 is a protein of the large ribosomal Subunit. A homolog, called heparin/heparan sulfate interacting protein (HIP), has also been identified in mammals. L29 is located on the surface of the large ribosomal subunit, where it...; Region: Ribosomal_L29_HIP; cd00427 272562009683 23S rRNA interface [nucleotide binding]; other site 272562009684 putative translocon interaction site; other site 272562009685 signal recognition particle (SRP54) interaction site; other site 272562009686 L23 interface [polypeptide binding]; other site 272562009687 trigger factor interaction site; other site 272562009688 Ribosomal_L16_L10e: L16 is an essential protein in the large ribosomal subunit of bacteria, mitochondria, and chloroplasts. Large subunits that lack L16 are defective in peptidyl transferase activity, peptidyl-tRNA hydrolysis activity, association with...; Region: Ribosomal_L16_L10e; cd01433 272562009689 23S rRNA interface [nucleotide binding]; other site 272562009690 5S rRNA interface [nucleotide binding]; other site 272562009691 putative antibiotic binding site [chemical binding]; other site 272562009692 L25 interface [polypeptide binding]; other site 272562009693 L27 interface [polypeptide binding]; other site 272562009694 30S ribosomal protein S3; Reviewed; Region: rpsC; PRK00310 272562009695 K homology RNA-binding (KH) domain of the prokaryotic 30S small ribosomal subunit protein S3. S3 is part of the head region of the 30S ribosomal subunit and is believed to interact with mRNA as it threads its way from the latch into the channel. The KH...; Region: 30S_S3_KH; cd02412 272562009696 G-X-X-G motif; other site 272562009697 Ribosomal protein S3, C-terminal domain; Region: Ribosomal_S3_C; pfam00189 272562009698 Ribosomal protein L22/L17e. L22 (L17 in eukaryotes) is a core protein of the large ribosomal subunit. It is the only ribosomal protein that interacts with all six domains of 23S rRNA, and is one of the proteins important for directing the proper...; Region: Ribosomal_L22; cd00336 272562009699 putative translocon binding site; other site 272562009700 protein-rRNA interface [nucleotide binding]; other site 272562009701 30S ribosomal protein S19; Reviewed; Region: rpsS; PRK00357 272562009702 50S ribosomal protein L2; Validated; Region: rplB; PRK09374 272562009703 Ribosomal Proteins L2, RNA binding domain; Region: Ribosomal_L2; pfam00181 272562009704 Ribosomal Proteins L2, C-terminal domain; Region: Ribosomal_L2_C; pfam03947 272562009705 50S ribosomal protein L23; Reviewed; Region: rplW; PRK05738 272562009706 50S ribosomal protein L4; Provisional; Region: rplD; PRK05319 272562009707 50S ribosomal protein L3; Validated; Region: rplC; PRK00001 272562009708 30S ribosomal protein S10; Reviewed; Region: rpsJ; PRK00596 272562009709 elongation factor Tu; Reviewed; Region: PRK00049 272562009710 Elongation Factor Tu (EF-Tu) GTP-binding proteins; Region: EF_Tu; cd01884 272562009711 G1 box; other site 272562009712 GEF interaction site [polypeptide binding]; other site 272562009713 GTP/Mg2+ binding site [chemical binding]; other site 272562009714 Switch I region; other site 272562009715 G2 box; other site 272562009716 G3 box; other site 272562009717 Switch II region; other site 272562009718 G4 box; other site 272562009719 G5 box; other site 272562009720 EFTU_II: Elongation factor Tu domain II. Elongation factors Tu (EF-Tu) are three-domain GTPases with an essential function in the elongation phase of mRNA translation. The GTPase center of EF-Tu is in the N-terminal domain (domain I), also known as the...; Region: EFTU_II; cd03697 272562009721 Domain III of elongation factor (EF) Tu. Ef-Tu consists of three structural domains, designated I, II and III. Domain III adopts a beta barrel structure. Domain III is involved in binding to both charged tRNA and binding to elongation factor Ts (EF-Ts); Region: EFTU_III; cd03707 272562009722 Antibiotic Binding Site [chemical binding]; other site 272562009723 elongation factor G; Reviewed; Region: PRK00007 272562009724 Elongation factor G (EF-G) family involved in both the elongation and ribosome recycling phases of protein synthesis; Region: EF-G; cd01886 272562009725 G1 box; other site 272562009726 putative GEF interaction site [polypeptide binding]; other site 272562009727 GTP/Mg2+ binding site [chemical binding]; other site 272562009728 Switch I region; other site 272562009729 G2 box; other site 272562009730 G3 box; other site 272562009731 Switch II region; other site 272562009732 G4 box; other site 272562009733 G5 box; other site 272562009734 EFG_mtEFG_II: this subfamily represents the domain II of elongation factor G (EF-G) in bacteria and, the C-terminus of mitochondrial Elongation factor G1 (mtEFG1) and G2 (mtEFG2)_like proteins found in eukaryotes. During the process of peptide synthesis...; Region: EFG_mtEFG_II; cd04088 272562009735 Elongation Factor G, domain II; Region: EFG_II; pfam14492 272562009736 EFG_mtEFG1_IV: domains similar to domain IV of the bacterial translational elongation factor (EF) EF-G. Included in this group is a domain of mitochondrial Elongation factor G1 (mtEFG1) proteins homologous to domain IV of EF-G. Eukaryotic cells harbor 2...; Region: EFG_mtEFG1_IV; cd01434 272562009737 EFG_mtEFG_C: domains similar to the C-terminal domain of the bacterial translational elongation factor (EF) EF-G. Included in this group is the C-terminus of mitochondrial Elongation factor G1 (mtEFG1) and G2 (mtEFG2) proteins. Eukaryotic cells harbor 2...; Region: EFG_mtEFG_C; cd03713 272562009738 30S ribosomal protein S7; Validated; Region: PRK05302 272562009739 S12-like family, 30S ribosomal protein S12 subfamily; S12 is located at the interface of the large and small ribosomal subunits of prokaryotes, chloroplasts and mitochondria, where it plays an important role in both tRNA and ribosomal subunit...; Region: Ribosomal_S12; cd03368 272562009740 S17 interaction site [polypeptide binding]; other site 272562009741 S8 interaction site; other site 272562009742 16S rRNA interaction site [nucleotide binding]; other site 272562009743 streptomycin interaction site [chemical binding]; other site 272562009744 23S rRNA interaction site [nucleotide binding]; other site 272562009745 aminoacyl-tRNA interaction site (A-site) [nucleotide binding]; other site 272562009746 Ribosomal protein L7Ae/L30e/S12e/Gadd45 family; Region: Ribosomal_L7Ae; cl00600 272562009747 DNA-directed RNA polymerase subunit beta'; Provisional; Region: PRK00566 272562009748 Largest subunit (beta') of bacterial DNA-dependent RNA polymerase (RNAP), N-terminal domain; Region: RNAP_beta'_N; cd01609 272562009749 beta and beta' interface [polypeptide binding]; other site 272562009750 beta' and sigma factor interface [polypeptide binding]; other site 272562009751 Zn-binding [ion binding]; other site 272562009752 active site region [active] 272562009753 catalytic site [active] 272562009754 Largest subunit (beta') of Bacterial DNA-dependent RNA polymerase (RNAP), C-terminal domain; Region: RNAP_beta'_C; cd02655 272562009755 Rpb1 (beta') - Rpb6 (omega) interaction site [polypeptide binding]; other site 272562009756 Rpb1 (beta') - Rpb2 (beta) interaction site [polypeptide binding]; other site 272562009757 G-loop; other site 272562009758 DNA binding site [nucleotide binding] 272562009759 Apocytochrome F, C-terminal; Region: Apocytochr_F_C; cl03168 272562009760 DNA-directed RNA polymerase subunit beta; Reviewed; Region: rpoB; PRK00405 272562009761 RNA polymerase beta subunit. RNA polymerases catalyse the DNA dependent polymerization of RNA. Prokaryotes contain a single RNA polymerase compared to three in eukaryotes (not including mitochondrial. and chloroplast polymerases). Each RNA polymerase...; Region: RNA_pol_B_RPB2; cd00653 272562009762 RPB12 interaction site [polypeptide binding]; other site 272562009763 RNA polymerase beta subunit; Region: RNA_pol_Rpb2_1; cl19478 272562009764 RPB1 interaction site [polypeptide binding]; other site 272562009765 RNA polymerase beta subunit external 1 domain; Region: RNA_pol_Rpb2_45; pfam10385 272562009766 RPB10 interaction site [polypeptide binding]; other site 272562009767 RPB11 interaction site [polypeptide binding]; other site 272562009768 RPB3 interaction site [polypeptide binding]; other site 272562009769 Ribosomal protein L7/L12. Ribosomal protein L7/L12 refers to the large ribosomal subunit proteins L7 and L12, which are identical except that L7 is acetylated at the N terminus. It is a component of the L7/L12 stalk, which is located at the surface of...; Region: Ribosomal_L7_L12; cd00387 272562009770 core dimer interface [polypeptide binding]; other site 272562009771 peripheral dimer interface [polypeptide binding]; other site 272562009772 L10 interface [polypeptide binding]; other site 272562009773 L11 interface [polypeptide binding]; other site 272562009774 putative EF-Tu interaction site [polypeptide binding]; other site 272562009775 putative EF-G interaction site [polypeptide binding]; other site 272562009776 Ribosomal protein L10 family, L10 subfamily; composed of bacterial 50S ribosomal protein and eukaryotic mitochondrial 39S ribosomal protein, L10. L10 occupies the L7/L12 stalk of the ribosome. The N-terminal domain (NTD) of L10 interacts with L11 protein...; Region: Ribosomal_L10; cd05797 272562009777 23S rRNA interface [nucleotide binding]; other site 272562009778 Interface with L7/L12 ribosomal proteins [polypeptide binding]; other site 272562009779 Ribosomal protein L1. The L1 protein, located near the E-site of the ribosome, forms part of the L1 stalk along with 23S rRNA. In bacteria and archaea, L1 functions both as a ribosomal protein that binds rRNA, and as a translation repressor that binds...; Region: Ribosomal_L1; cd00403 272562009780 mRNA/rRNA interface [nucleotide binding]; other site 272562009781 50S ribosomal protein L11; Validated; Region: rplK; PRK00140 272562009782 Ribosomal protein L11. Ribosomal protein L11, together with proteins L10 and L7/L12, and 23S rRNA, form the L7/L12 stalk on the surface of the large subunit of the ribosome. The homologous eukaryotic cytoplasmic protein is also called 60S ribosomal...; Region: Ribosomal_L11; cd00349 272562009783 23S rRNA interface [nucleotide binding]; other site 272562009784 L7/L12 interface [polypeptide binding]; other site 272562009785 putative thiostrepton binding site; other site 272562009786 L25 interface [polypeptide binding]; other site 272562009787 transcription antitermination protein NusG; Validated; Region: nusG; PRK05609 272562009788 Bacterial N-Utilization Substance G (NusG) N-terminal (NGN) domain, subgroup 1; Region: NGN_Bact_1; cd09891 272562009789 putative homodimer interface [polypeptide binding]; other site 272562009790 NusG contains an NGN domain at its N-terminus and KOW motif at its C-terminus; Region: KOW_NusG; cd06091 272562009791 heterodimer interface [polypeptide binding]; other site 272562009792 homodimer interface [polypeptide binding]; other site 272562009793 Preprotein translocase subunit SecE [Intracellular trafficking and secretion]; Region: SecE; COG0690 272562009794 50S ribosomal protein L33; Validated; Region: rpmG; PRK00504 272562009795 elongation factor Tu; Reviewed; Region: PRK00049 272562009796 Elongation Factor Tu (EF-Tu) GTP-binding proteins; Region: EF_Tu; cd01884 272562009797 G1 box; other site 272562009798 GEF interaction site [polypeptide binding]; other site 272562009799 GTP/Mg2+ binding site [chemical binding]; other site 272562009800 Switch I region; other site 272562009801 G2 box; other site 272562009802 G3 box; other site 272562009803 Switch II region; other site 272562009804 G4 box; other site 272562009805 G5 box; other site 272562009806 EFTU_II: Elongation factor Tu domain II. Elongation factors Tu (EF-Tu) are three-domain GTPases with an essential function in the elongation phase of mRNA translation. The GTPase center of EF-Tu is in the N-terminal domain (domain I), also known as the...; Region: EFTU_II; cd03697 272562009807 Domain III of elongation factor (EF) Tu. Ef-Tu consists of three structural domains, designated I, II and III. Domain III adopts a beta barrel structure. Domain III is involved in binding to both charged tRNA and binding to elongation factor Ts (EF-Ts); Region: EFTU_III; cd03707 272562009808 Antibiotic Binding Site [chemical binding]; other site 272562009809 RNA polymerase factor sigma-70; Validated; Region: PRK08295 272562009810 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 272562009811 Rat sarcoma (Ras)-like superfamily of small guanosine triphosphatases (GTPases); Region: Ras_like_GTPase; cl17170 272562009812 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cl17315 272562009813 DNA binding residues [nucleotide binding] 272562009814 Predicted RNA-binding protein containing a PIN domain [General function prediction only]; Region: COG3688 272562009815 rRNA methylases [Translation, ribosomal structure and biogenesis]; Region: SpoU; COG0566 272562009816 RNA 2'-O ribose methyltransferase substrate binding; Region: SpoU_sub_bind; pfam08032 272562009817 SpoU rRNA Methylase family; Region: SpoU_methylase; pfam00588 272562009818 Predicted alternative thymidylate synthase [Nucleotide transport and metabolism]; Region: THY1; COG1351 272562009819 RIBOc. Ribonuclease III C terminal domain. This group consists of eukaryotic, bacterial and archeal ribonuclease III (RNAse III) proteins. RNAse III is a double stranded RNA-specific endonuclease. Prokaryotic RNAse III is important in...; Region: RIBOc; cd00593 272562009820 active site 272562009821 metal binding site [ion binding]; metal-binding site 272562009822 dimerization interface [polypeptide binding]; other site 272562009823 Ttryptophan synthase (TRPS) alpha subunit (TSA). TPRS is a bifunctional tetrameric enzyme (2 alpha and 2 beta subunits) that catalyzes the last two steps of L-tryptophan biosynthesis. Alpha and beta subunit catalyze two distinct reactions which are both...; Region: Tryptophan_synthase_alpha; cd04724 272562009824 substrate binding site [chemical binding]; other site 272562009825 active site 272562009826 catalytic residues [active] 272562009827 heterodimer interface [polypeptide binding]; other site 272562009828 Tryptophan synthase-beta: Trptophan synthase is a bifunctional enzyme that catalyses the last two steps in the biosynthesis of L-tryptophan via its alpha and beta reactions. In the alpha reaction, indole 3-glycerol phosphate is cleaved reversibly to...; Region: Trp-synth_B; cd06446 272562009829 threonine synthase; Validated; Region: PRK06450 272562009830 pyridoxal 5'-phosphate binding site [chemical binding]; other site 272562009831 catalytic residue [active] 272562009832 Phosphoribosylanthranilate isomerase (PRAI) catalyzes the fourth step of the tryptophan biosynthesis, the conversion of N-(5'- phosphoribosyl)-anthranilate (PRA) to 1-(o-carboxyphenylamino)- 1-deoxyribulose 5-phosphate (CdRP). Most PRAIs are...; Region: PRAI; cd00405 272562009833 active site 272562009834 Indole-3-glycerol phosphate synthase (IGPS); an enzyme in the tryptophan biosynthetic pathway, catalyzing the ring closure reaction of 1-(o-carboxyphenylamino)-1-deoxyribulose-5-phosphate (CdRP) to indole-3-glycerol phosphate (IGP), accompanied by the...; Region: IGPS; cd00331 272562009835 active site 272562009836 ribulose/triose binding site [chemical binding]; other site 272562009837 phosphate binding site [ion binding]; other site 272562009838 substrate (anthranilate) binding pocket [chemical binding]; other site 272562009839 product (indole) binding pocket [chemical binding]; other site 272562009840 anthranilate phosphoribosyltransferase; Provisional; Region: trpD; PRK00188 272562009841 Glycosyl transferase family, helical bundle domain; Region: Glycos_trans_3N; pfam02885 272562009842 Glycosyl transferase family, a/b domain; Region: Glycos_transf_3; pfam00591 272562009843 para-aminobenzoate synthase component II; Provisional; Region: PRK08857 272562009844 Type 1 glutamine amidotransferase (GATase1) domain found in Anthranilate synthase; Region: GATase1_Anthranilate_Synthase; cd01743 272562009845 glutamine binding [chemical binding]; other site 272562009846 catalytic triad [active] 272562009847 anthranilate synthase component I; Provisional; Region: PRK13570 272562009848 Anthranilate synthase component I, N terminal region; Region: Anth_synt_I_N; pfam04715 272562009849 chorismate binding enzyme; Region: Chorismate_bind; pfam00425 272562009850 lysine transporter; Provisional; Region: PRK10836 272562009851 Transmembrane amino acid transporter protein; Region: Aa_trans; cl17468 272562009852 Predicted DNA-binding proteins [General function prediction only]; Region: COG1342 272562009853 RNA polymerase sigma factor, sigma-70 family; Region: sigma70-ECF; TIGR02937 272562009854 DNA binding residues [nucleotide binding] 272562009855 This uncharacterized conserved protein belongs to a family of iron-molybdenum cluster-binding proteins that includes NifX, NifB, and NifY, all of which are involved in the synthesis of an iron-molybdenum cofactor (FeMo-co) that binds the active site of...; Region: MTH1175; cd00851 272562009856 acetolactate synthase, large subunit, biosynthetic type; Region: acolac_lg; TIGR00118 272562009857 Pyrimidine (PYR) binding domain of POX and related proteins; Region: TPP_PYR_POX_like; cd07035 272562009858 PYR/PP interface [polypeptide binding]; other site 272562009859 dimer interface [polypeptide binding]; other site 272562009860 TPP binding site [chemical binding]; other site 272562009861 Thiamine pyrophosphate enzyme, central domain; Region: TPP_enzyme_M; pfam00205 272562009862 Thiamine pyrophosphate (TPP) family, Acetohydroxyacid synthase (AHAS) subfamily, TPP-binding module; composed of proteins similar to the large catalytic subunit of AHAS. AHAS catalyzes the condensation of two molecules of pyruvate to give the...; Region: TPP_AHAS; cd02015 272562009863 TPP-binding site [chemical binding]; other site 272562009864 dimer interface [polypeptide binding]; other site 272562009865 dihydroxy-acid dehydratase; Provisional; Region: PRK00911 272562009866 3-isopropylmalate dehydrogenase; Provisional; Region: PRK00772 272562009867 Aconatase-like swivel domain of 3-isopropylmalate dehydratase and related uncharacterized proteins. 3-isopropylmalate dehydratase catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate...; Region: IPMI_Swivel; cd01577 272562009868 substrate binding site [chemical binding]; other site 272562009869 3-isopropylmalate dehydratase catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate; Region: IPMI; cd01583 272562009870 substrate binding site [chemical binding]; other site 272562009871 ligand binding site [chemical binding]; other site 272562009872 putative alpha-isopropylmalate/homocitrate synthase family transferase; Provisional; Region: PRK12344 272562009873 Desulfobacterium autotrophicum LeuA3 and related proteins, N-terminal catalytic TIM barrel domain; Region: DRE_TIM_LeuA3; cd07941 272562009874 active site 272562009875 catalytic residues [active] 272562009876 metal binding site [ion binding]; metal-binding site 272562009877 Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 residue sequence motifs present in many proteins that participate in protein-protein interactions and have different functions and cellular locations. LRRs correspond...; Region: LRR_RI; cd00116 272562009878 LeuA allosteric (dimerisation) domain; Region: LeuA_dimer; smart00917 272562009879 N-terminal ACT domain of the Escherichia coli IlvH-like regulatory subunit of acetohydroxyacid synthase (AHAS); Region: ACT_AHAS; cd04878 272562009880 acetolactate synthase 3 regulatory subunit; Reviewed; Region: ilvH; PRK11895 272562009881 putative valine binding site [chemical binding]; other site 272562009882 dimer interface [polypeptide binding]; other site 272562009883 Small subunit of acetolactate synthase; Region: ALS_ss_C; pfam10369 272562009884 cysteinyl-tRNA synthetase; Validated; Region: cysS; PRK00260 272562009885 catalytic core domain of cysteinyl tRNA synthetase; Region: CysRS_core; cd00672 272562009886 active site 272562009887 HIGH motif; other site 272562009888 KMSKS motif; other site 272562009889 Anticodon-binding domain of cysteinyl tRNA synthetases; Region: Anticodon_Ia_Cys; cd07963 272562009890 tRNA binding surface [nucleotide binding]; other site 272562009891 anticodon binding site; other site 272562009892 prolyl-tRNA synthetase; Provisional; Region: PRK09194 272562009893 Prolyl-tRNA synthetase (ProRS) class II core catalytic domain. ProRS is a homodimer. It is responsible for the attachment of proline to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for ATP-dependent...; Region: ProRS_core_prok; cd00779 272562009894 dimer interface [polypeptide binding]; other site 272562009895 motif 1; other site 272562009896 active site 272562009897 motif 2; other site 272562009898 INS is an amino acid-editing domain inserted (INS) into the bacterial class II prolyl-tRNA synthetase (ProRS) however, this CD is not exclusively bacterial. It is also found at the N-terminus of the eukaryotic/archaea-like ProRS's of yeasts and...; Region: ProRS-INS; cd04334 272562009899 putative deacylase active site [active] 272562009900 motif 3; other site 272562009901 ProRS Prolyl-anticodon binding domain, short version found predominantly in bacteria. ProRS belongs to class II aminoacyl-tRNA synthetases (aaRS). This alignment contains the anticodon binding domain, which is responsible for specificity in tRNA-binding; Region: ProRS_anticodon_short; cd00861 272562009902 anticodon binding site; other site 272562009903 ABC-type dipeptide transport system, periplasmic component [Amino acid transport and metabolism]; Region: DdpA; COG0747 272562009904 The substrate-binding domain of an ABC-type nickel/oligopeptide-like import system contains the type 2 periplasmic binding fold; Region: PBP2_NikA_DppA_OppA_like; cd00995 272562009905 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppB; COG0601 272562009906 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 272562009907 dimer interface [polypeptide binding]; other site 272562009908 conserved gate region; other site 272562009909 putative PBP binding loops; other site 272562009910 ABC-ATPase subunit interface; other site 272562009911 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppC; COG1173 272562009912 N-terminal TM domain of oligopeptide transport permease C; Region: OppC_N; pfam12911 272562009913 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 272562009914 dimer interface [polypeptide binding]; other site 272562009915 conserved gate region; other site 272562009916 putative PBP binding loops; other site 272562009917 ABC-ATPase subunit interface; other site 272562009918 ABC-type dipeptide/oligopeptide/nickel transport system, ATPase component [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppD; COG0444 272562009919 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 272562009920 Walker A/P-loop; other site 272562009921 ATP binding site [chemical binding]; other site 272562009922 Q-loop/lid; other site 272562009923 ABC transporter signature motif; other site 272562009924 Walker B; other site 272562009925 D-loop; other site 272562009926 H-loop/switch region; other site 272562009927 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097 272562009928 ABC-type oligopeptide transport system, ATPase component [Amino acid transport and metabolism]; Region: AppF; COG4608 272562009929 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 272562009930 Walker A/P-loop; other site 272562009931 ATP binding site [chemical binding]; other site 272562009932 Q-loop/lid; other site 272562009933 ABC transporter signature motif; other site 272562009934 Walker B; other site 272562009935 D-loop; other site 272562009936 H-loop/switch region; other site 272562009937 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097 272562009938 CDP-ME synthetase is involved in mevalonate-independent isoprenoid production; Region: CDP-ME_synthetase; cd02516 272562009939 substrate binding site; other site 272562009940 dimer interface; other site 272562009941 Integral membrane protein (PIN domain superfamily) [General function prediction only]; Region: COG4956 272562009942 PIN domain of Thermus Thermophilus Hb8, uncharacterized Bacillus subtilis YacL, and other bacterial homologs; Region: PIN_YacL; cd09877 272562009943 putative active site [active] 272562009944 TRAM domain; Region: TRAM; cl01282 272562009945 Nucleoside Triphosphate Pyrophosphohydrolase (EC 3.6.1.8) MazG-like domain superfamily; Region: NTP-PPase; cl16941 272562009946 DNA integrity scanning protein DisA; Provisional; Region: PRK13482 272562009947 DisA bacterial checkpoint controller nucleotide-binding; Region: DisA_N; pfam02457 272562009948 DisA bacterial checkpoint controller linker region; Region: DisA-linker; pfam10635 272562009949 Helix-hairpin-helix motif; Region: HHH; pfam00633 272562009950 DNA repair protein RadA; Provisional; Region: PRK11823 272562009951 Sms (bacterial radA) DNA repair protein. This protein is not related to archael radA any more than is to other RecA-like NTPases. Sms has a role in recombination and recombinational repair and is responsible for the stabilization or processing of...; Region: Sms; cd01121 272562009952 Walker A motif/ATP binding site; other site 272562009953 ATP binding site [chemical binding]; other site 272562009954 Walker B motif; other site 272562009955 Subunit ChlI of Mg-chelatase; Region: ChlI; pfam13541 272562009956 ATP-binding subunits of Clp protease and DnaK/DnaJ chaperones [Posttranslational modification, protein turnover, chaperones]; Region: clpA; COG0542 272562009957 Clp amino terminal domain; Region: Clp_N; pfam02861 272562009958 Clp amino terminal domain; Region: Clp_N; pfam02861 272562009959 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 272562009960 Walker A motif; other site 272562009961 ATP binding site [chemical binding]; other site 272562009962 Walker B motif; other site 272562009963 arginine finger; other site 272562009964 UvrB/uvrC motif; Region: UVR; pfam02151 272562009965 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 272562009966 Walker A motif; other site 272562009967 ATP binding site [chemical binding]; other site 272562009968 Walker B motif; other site 272562009969 C-terminal, D2-small domain, of ClpB protein; Region: ClpB_D2-small; pfam10431 272562009970 ATP:guanido phosphotransferase; Provisional; Region: PRK01059 272562009971 Phosphagen (guanidino) kinases found in bacteria; Region: bacterial_phosphagen_kinase; cd07930 272562009972 ADP binding site [chemical binding]; other site 272562009973 phosphagen binding site; other site 272562009974 substrate specificity loop; other site 272562009975 Modulator of heat shock repressor CtsR, McsA [Signal transduction mechanisms]; Region: COG3880 272562009976 UvrB/uvrC motif; Region: UVR; pfam02151 272562009977 Transcriptional repressor of class III stress genes [Transcription]; Region: CtsR; COG4463 272562009978 UDP-N-acetylmuramoyl-L-alanyl-D-glutamate synthetase; Provisional; Region: murD; PRK01710 272562009979 Aspartate/ornithine carbamoyltransferase, Asp/Orn binding domain; Region: OTCace; pfam00185 272562009980 Mur ligase middle domain; Region: Mur_ligase_M; pfam08245 272562009981 glycyl-tRNA synthetase; Provisional; Region: PRK04173 272562009982 Glycyl-tRNA synthetase (GlyRS)-like class II core catalytic domain. GlyRS functions as a homodimer in eukaryotes, archaea and some bacteria and as a heterotetramer in the remainder of prokaryotes. It is responsible for the attachment of glycine to the 3...; Region: GlyRS-like_core; cd00774 272562009983 dimer interface [polypeptide binding]; other site 272562009984 motif 1; other site 272562009985 active site 272562009986 motif 2; other site 272562009987 motif 3; other site 272562009988 GlyRS Glycyl-anticodon binding domain. GlyRS belongs to class II aminoacyl-tRNA synthetases (aaRS). This alignment contains the anticodon binding domain, which is responsible for specificity in tRNA-binding, so that the activated amino acid is...; Region: GlyRS_anticodon; cd00858 272562009989 anticodon binding site; other site 272562009990 lysyl-tRNA synthetase; Reviewed; Region: lysS; PRK00484 272562009991 LysRS_N: N-terminal, anticodon recognition domain of lysyl-tRNA synthetases (LysRS). These enzymes are homodimeric class 2b aminoacyl-tRNA synthetases (aaRSs). This domain is a beta-barrel domain (OB fold) involved in binding the tRNA anticodon stem-loop; Region: LysRS_N; cd04322 272562009992 dimer interface [polypeptide binding]; other site 272562009993 putative anticodon binding site; other site 272562009994 Lys_tRNA synthetase (LysRS) class II core domain. Class II LysRS is a dimer which attaches a lysine to the 3' OH group of ribose of the appropriate tRNA. Its assignment to class II aaRS is based upon its structure and the presence of three...; Region: LysRS_core; cd00775 272562009995 motif 1; other site 272562009996 active site 272562009997 motif 2; other site 272562009998 motif 3; other site 272562009999 transcription elongation factor GreA; Reviewed; Region: greA; PRK00226 272562010000 Transcription elongation factor, N-terminal; Region: GreA_GreB_N; pfam03449 272562010001 Transcription elongation factor, GreA/GreB, C-term; Region: GreA_GreB; pfam01272 272562010002 putative TIM-barrel protein, nifR3 family; Region: nifR3_yhdG; TIGR00737 272562010003 Dihydrouridine synthase-like (DUS-like) FMN-binding domain. Members of this family catalyze the reduction of the 5,6-double bond of a uridine residue on tRNA. Dihydrouridine modification of tRNA is widely observed in prokaryotes and eukaryotes, and also...; Region: DUS_like_FMN; cd02801 272562010004 FMN binding site [chemical binding]; other site 272562010005 active site 272562010006 catalytic residues [active] 272562010007 substrate binding site [chemical binding]; other site 272562010008 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cd00012 272562010009 nucleotide binding site [chemical binding]; other site 272562010010 Formyltetrahydrofolate synthetase (FTHFS) catalyzes the ATP-dependent activation of formate ion via its addition to the N10 position of tetrahydrofolate. FTHFS is a highly expressed key enzyme in both the Wood-Ljungdahl pathway of autotrophic CO2...; Region: FTHFS; cd00477 272562010011 Potassium binding sites [ion binding]; other site 272562010012 Cesium cation binding sites [ion binding]; other site 272562010013 FtsH Extracellular; Region: FtsH_ext; pfam06480 272562010014 ATP-dependent metalloprotease FtsH; Region: FtsH_fam; TIGR01241 272562010015 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 272562010016 Walker A motif; other site 272562010017 ATP binding site [chemical binding]; other site 272562010018 Walker B motif; other site 272562010019 arginine finger; other site 272562010020 Peptidase family M41; Region: Peptidase_M41; pfam01434 272562010021 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 272562010022 active site 272562010023 tRNA(Ile)-lysidine synthase MesJ [Cell cycle control, cell division, chromosome partitioning]; Region: MesJ; COG0037 272562010024 N-terminal domain of predicted ATPase of the PP-loop faimly implicated in cell cycle control [Cell division and chromosome partitioning]. This is a subfamily of Adenine nucleotide alpha hydrolases superfamily.Adeninosine nucleotide alpha hydrolases...; Region: PP-ATPase; cd01992 272562010025 Ligand Binding Site [chemical binding]; other site 272562010026 TilS substrate C-terminal domain; Region: TilS_C; smart00977 272562010027 stage II sporulation protein E; Region: spore_II_E; TIGR02865 272562010028 Stage II sporulation protein E (SpoIIE); Region: SpoIIE; pfam07228 272562010029 hypothetical protein; Provisional; Region: PRK05807 272562010030 S1_like: Ribosomal protein S1-like RNA-binding domain. Found in a wide variety of RNA-associated proteins. Originally identified in S1 ribosomal protein. This superfamily also contains the Cold Shock Domain (CSD), which is a homolog of the S1 domain; Region: S1_like; cl09927 272562010031 RNA binding site [nucleotide binding]; other site 272562010032 Septum formation initiator; Region: DivIC; pfam04977 272562010033 spore cortex biosynthesis protein YabQ; Region: spore_yabQ; TIGR02893 272562010034 sporulation protein YabP; Region: spore_yabP; TIGR02892 272562010035 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 272562010036 RNA binding surface [nucleotide binding]; other site 272562010037 histone-like DNA-binding protein HU; Region: HU; cd13831 272562010038 dimer interface [polypeptide binding]; other site 272562010039 DNA binding site [nucleotide binding] 272562010040 Protein containing tetrapyrrole methyltransferase domain and MazG-like (predicted pyrophosphatase) domain [General function prediction only]; Region: COG3956 272562010041 N-terminal S-AdoMet dependent methylase domain of Bacillus subtilis YabN and related proteins; Region: YabN_N; cd11723 272562010042 putative SAM binding site [chemical binding]; other site 272562010043 putative homodimer interface [polypeptide binding]; other site 272562010044 Nucleoside Triphosphate Pyrophosphohydrolase (EC 3.6.1.8) N-terminal tandem-domain of MazG proteins from Escherichia coli and bacterial homologs; Region: NTP-PPase_MazG_Nterm; cd11528 272562010045 homodimer interface [polypeptide binding]; other site 272562010046 metal binding site [ion binding]; metal-binding site 272562010047 Nucleoside Triphosphate Pyrophosphohydrolase (EC 3.6.1.8) C-terminal tandem-domain of MazG proteins from Escherichia coli and bacterial homologs' Region: NTP-PPase_MazG_Cterm; cd11529 272562010048 homodimer interface [polypeptide binding]; other site 272562010049 active site 272562010050 putative chemical substrate binding site [chemical binding]; other site 272562010051 metal binding site [ion binding]; metal-binding site 272562010052 stage V sporulation protein B; Region: spore_V_B; TIGR02900 272562010053 Stage V sporulation protein B, also known as Stage III sporulation protein F, and related proteins; Region: MATE_SpoVB_like; cd13124 272562010054 Regulators of stationary/sporulation gene expression [Transcription]; Region: AbrB; COG2002 272562010055 stage V sporulation protein T; Region: spore_V_T; TIGR02851 272562010056 peptidylprolyl isomerase; Provisional; Region: prsA; PRK00059 272562010057 SurA N-terminal domain; Region: SurA_N; pfam09312 272562010058 PPIC-type PPIASE domain; Region: Rotamase; pfam00639 272562010059 Transcription-repair coupling factor (superfamily II helicase) [DNA replication, recombination, and repair / Transcription]; Region: Mfd; COG1197 272562010060 CarD-like/TRCF domain; Region: CarD_TRCF; smart01058 272562010061 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 272562010062 ATP binding site [chemical binding]; other site 272562010063 putative Mg++ binding site [ion binding]; other site 272562010064 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 272562010065 nucleotide binding region [chemical binding]; other site 272562010066 ATP-binding site [chemical binding]; other site 272562010067 This domain is found in proteins necessary for strand-specific repair in DNA such as TRCF in Escherichia coli; Region: TRCF; smart00982 272562010068 Peptidyl-tRNA hydrolase (PTH) is a monomeric protein that cleaves the ester bond linking the nascent peptide and tRNA when peptidyl-tRNA is released prematurely from the ribosome. This ensures the recycling of peptidyl-tRNAs into tRNAs produced through...; Region: PTH; cd00462 272562010069 putative active site [active] 272562010070 catalytic residue [active] 272562010071 Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain [Posttranslational modification, protein turnover, chaperones]; Region: DegQ; COG0265 272562010072 Trypsin-like peptidase domain; Region: Trypsin_2; pfam13365 272562010073 PDZ domain of trypsin-like serine proteases, such as DegP/HtrA, which are oligomeric proteins involved in heat-shock response, chaperone function, and apoptosis. May be responsible for substrate recognition and/or binding, as most PDZ domains bind...; Region: PDZ_serine_protease; cd00987 272562010074 protein binding site [polypeptide binding]; other site 272562010075 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 272562010076 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 272562010077 dimerization interface [polypeptide binding]; other site 272562010078 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 272562010079 dimer interface [polypeptide binding]; other site 272562010080 phosphorylation site [posttranslational modification] 272562010081 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 272562010082 ATP binding site [chemical binding]; other site 272562010083 Mg2+ binding site [ion binding]; other site 272562010084 G-X-G motif; other site 272562010085 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 272562010086 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 272562010087 active site 272562010088 phosphorylation site [posttranslational modification] 272562010089 intermolecular recognition site; other site 272562010090 dimerization interface [polypeptide binding]; other site 272562010091 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 272562010092 DNA binding site [nucleotide binding] 272562010093 ribose-phosphate pyrophosphokinase; Provisional; Region: PRK01259 272562010094 N-terminal domain of ribose phosphate pyrophosphokinase; Region: Pribosyltran_N; pfam13793 272562010095 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 272562010096 active site 272562010097 bifunctional N-acetylglucosamine-1-phosphate uridyltransferase/glucosamine-1-phosphate acetyltransferase; Provisional; Region: glmU; PRK14354 272562010098 N-terminal domain of bacterial GlmU; Region: GT2_GlmU_N_bac; cd02540 272562010099 Substrate binding site; other site 272562010100 Mg++ binding site; other site 272562010101 N-acetyl-glucosamine-1-phosphate uridyltransferase (GlmU), C-terminal left-handed beta-helix (LbH) acetyltransferase domain: GlmU is also known as UDP-N-acetylglucosamine pyrophosphorylase. It is a bifunctional bacterial enzyme that catalyzes two...; Region: LbH_GlmU_C; cd03353 272562010102 active site 272562010103 substrate binding site [chemical binding]; other site 272562010104 CoA binding site [chemical binding]; other site 272562010105 regulatory protein SpoVG; Reviewed; Region: PRK13259 272562010106 pur operon repressor; Provisional; Region: PRK09213 272562010107 Bacterial purine repressor, N-terminal; Region: PuR_N; pfam09182 272562010108 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 272562010109 active site 272562010110 UDP-N-acetylmuramate--L-alanine ligase; Provisional; Region: murC; PRK00421 272562010111 Mur ligase family, catalytic domain; Region: Mur_ligase; pfam01225 272562010112 Mur ligase middle domain; Region: Mur_ligase_M; pfam08245 272562010113 Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875 272562010114 Old yellow enzyme (OYE) YqjM-like FMN binding domain. YqjM is involved in the oxidative stress response of Bacillus subtilis. Like the other OYE members, each monomer of YqjM contains FMN as a non-covalently bound cofactor and uses NADPH as a reducing...; Region: OYE_YqiM_FMN; cd02932 272562010115 active site 272562010116 FMN binding site [chemical binding]; other site 272562010117 substrate binding site [chemical binding]; other site 272562010118 homotetramer interface [polypeptide binding]; other site 272562010119 catalytic residue [active] 272562010120 Iron only hydrogenase large subunit, C-terminal domain [General function prediction only]; Region: COG4624 272562010121 The HCP family of iron-sulfur proteins includes hybrid cluster protein (HCP), acetyl-CoA synthase (ACS), and carbon monoxide dehydrogenase (CODH), all of which contain [Fe4-S4] metal clusters at their active sites. These proteins have a conserved...; Region: HCP_like; cl19102 272562010122 Iron only hydrogenase large subunit, C-terminal domain; Region: Fe_hyd_lg_C; pfam02906 272562010123 Predicted phosphatase/phosphohexomutase [General function prediction only]; Region: COG0637 272562010124 haloacid dehalogenase-like hydrolase; Region: HAD; cl19137 272562010125 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 272562010126 motif II; other site 272562010127 Bacterial SH3 domain; Region: SH3_3; pfam08239 272562010128 2-phosphosulfolactate phosphatase; Provisional; Region: PRK00886 272562010129 Predicted membrane protein [Function unknown]; Region: COG4640 272562010130 zinc-ribbon domain; Region: zinc_ribbon_2; pfam13240 272562010131 Predicted membrane protein [Function unknown]; Region: COG4640 272562010132 Regulator of polyketide synthase expression [Signal transduction mechanisms / Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG2508 272562010133 PucR C-terminal helix-turn-helix domain; Region: HTH_30; pfam13556 272562010134 glycerol-3-phosphate transporter ATP-binding subunit; Provisional; Region: ugpC; PRK11650 272562010135 The N-terminal ATPase domain of the maltose transporter, MalK; Region: ABC_MalK_N; cd03301 272562010136 Walker A/P-loop; other site 272562010137 ATP binding site [chemical binding]; other site 272562010138 Q-loop/lid; other site 272562010139 ABC transporter signature motif; other site 272562010140 Walker B; other site 272562010141 D-loop; other site 272562010142 H-loop/switch region; other site 272562010143 TOBE domain; Region: TOBE_2; pfam08402 272562010144 Predicted Fe-S oxidoreductase [General function prediction only]; Region: COG1242 272562010145 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 272562010146 Uncharacterized membrane protein [Function unknown]; Region: COG3949 272562010147 Radical SAM superfamily; Region: Radical_SAM; pfam04055 272562010148 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 272562010149 FeS/SAM binding site; other site 272562010150 Heme NO binding; Region: HNOB; pfam07700 272562010151 Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer); Region: MA; smart00283 272562010152 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cl19050 272562010153 dimer interface [polypeptide binding]; other site 272562010154 putative CheW interface [polypeptide binding]; other site 272562010155 Putative peptidoglycan-binding domain-containing protein [Cell envelope biogenesis, outer membrane]; Region: COG3409 272562010156 Putative peptidoglycan binding domain; Region: PG_binding_1; pfam01471 272562010157 Peptidase S8 family domain in CspA-like proteins; Region: Peptidases_S8_CspA-like; cd07478 272562010158 Subtilase family; Region: Peptidase_S8; pfam00082 272562010159 active site 272562010160 catalytic triad [active] 272562010161 Subtilisin-like serine proteases [Posttranslational modification, protein turnover, chaperones]; Region: AprE; COG1404 272562010162 Peptidase S8 family domain in CspA-like proteins; Region: Peptidases_S8_CspA-like; cd07478 272562010163 active site 272562010164 catalytic triad [active] 272562010165 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 272562010166 non-specific DNA binding site [nucleotide binding]; other site 272562010167 salt bridge; other site 272562010168 sequence-specific DNA binding site [nucleotide binding]; other site 272562010169 Peptidase S24 LexA-like proteins are involved in the SOS response leading to the repair of single-stranded DNA within the bacterial cell. This family includes: the lambda repressor CI/C2 family and related bacterial prophage repressor proteins; LexA (EC...; Region: S24_LexA-like; cd06529 272562010170 Catalytic site [active] 272562010171 Domain of unknown function (DUF3783); Region: DUF3783; pfam12646 272562010172 glutamate racemase; Provisional; Region: PRK00865 272562010173 Response regulator containing a CheY-like receiver domain and an HD-GYP domain [Transcription / Signal transduction mechanisms]; Region: COG3437 272562010174 Domain of unknown function (DUF3369); Region: DUF3369; pfam11849 272562010175 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 272562010176 Zn2+ binding site [ion binding]; other site 272562010177 Mg2+ binding site [ion binding]; other site 272562010178 pyrroline-5-carboxylate reductase; Reviewed; Region: PRK11880 272562010179 NADP oxidoreductase coenzyme F420-dependent; Region: F420_oxidored; pfam03807 272562010180 Pyrroline-5-carboxylate reductase dimerization; Region: P5CR_dimer; pfam14748 272562010181 gamma-glutamyl kinase; Provisional; Region: PRK05429 272562010182 AAK_G5K_ProB: Glutamate-5-kinase (G5K) catalyzes glutamate-dependent ATP cleavage; G5K transfers the terminal phosphoryl group of ATP to the gamma-carboxyl group of glutamate, in the first and controlling step of proline (and, in mammals, ornithine)...; Region: AAK_G5K_ProB; cd04242 272562010183 nucleotide binding site [chemical binding]; other site 272562010184 homotetrameric interface [polypeptide binding]; other site 272562010185 putative phosphate binding site [ion binding]; other site 272562010186 putative allosteric binding site; other site 272562010187 Gamma-glutamyl phosphate reductase (GPR), aldehyde dehydrogenase families 18 and 19; Region: ALDH_F18-19_ProA-GPR; cd07079 272562010188 putative catalytic cysteine [active] 272562010189 Acetyltransferase (GNAT) domain; Region: Acetyltransf_10; pfam13673 272562010190 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 272562010191 Coenzyme A binding pocket [chemical binding]; other site 272562010192 Syntaxin; Region: Syntaxin; cl00143 272562010193 asparaginyl-tRNA synthetase; Validated; Region: asnC; PRK03932 272562010194 EcAsnRS_like_N: N-terminal, anticodon recognition domain of the type found in Escherichia coli asparaginyl-tRNA synthetase (AsnRS) and, in Arabidopsis thaliana and Saccharomyces cerevisiae mitochondrial (mt) AsnRS. This domain is a beta-barrel domain (OB...; Region: EcAsnRS_like_N; cd04318 272562010195 putative dimer interface [polypeptide binding]; other site 272562010196 putative anticodon binding site; other site 272562010197 Asx tRNA synthetase (AspRS/AsnRS) class II core domain. Assignment to class II aminoacyl-tRNA synthetases (aaRS) based upon its structure and the presence of three characteristic sequence motifs in the core domain. This family includes AsnRS as well as...; Region: AsxRS_core; cd00776 272562010198 homodimer interface [polypeptide binding]; other site 272562010199 motif 1; other site 272562010200 motif 2; other site 272562010201 active site 272562010202 motif 3; other site 272562010203 Methylated DNA-protein cysteine methyltransferase [DNA replication, recombination, and repair]; Region: Ada; COG0350 272562010204 The DNA repair protein O6-alkylguanine-DNA alkyltransferase (ATase; also known as AGT, AGAT and MGMT) reverses O6-alkylation DNA damage by transferring O6-alkyl adducts to an active site cysteine irreversibly, without inducing DNA strand breaks. ATases...; Region: ATase; cd06445 272562010205 DNA binding site [nucleotide binding] 272562010206 active site 272562010207 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 272562010208 ATPases associated with a variety of cellular activities; Region: AAA; smart00382 272562010209 Walker A motif; other site 272562010210 ATP binding site [chemical binding]; other site 272562010211 Walker B motif; other site 272562010212 Uncharacterized conserved protein [Function unknown]; Region: COG3874 272562010213 Protein of unknown function (DUF2953); Region: DUF2953; pfam11167 272562010214 Putative zinc-finger; Region: zf-HC2; pfam13490 272562010215 DNA-directed RNA polymerase specialized sigma subunit, sigma24 homolog [Transcription]; Region: RpoE; COG1595 272562010216 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 272562010217 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 272562010218 DNA binding residues [nucleotide binding] 272562010219 ABC-type multidrug transport system, permease component [Defense mechanisms]; Region: COG0842 272562010220 ABC-2 type transporter; Region: ABC2_membrane; pfam01061 272562010221 ABC-type Na+ transport system, ATPase component [Energy production and conversion / Inorganic ion transport and metabolism]; Region: NatA; COG4555 272562010222 ATP-binding cassette domain of the drug resistance transporter and related proteins, subfamily A; Region: ABC_DR_subfamily_A; cd03230 272562010223 Walker A/P-loop; other site 272562010224 ATP binding site [chemical binding]; other site 272562010225 Q-loop/lid; other site 272562010226 ABC transporter signature motif; other site 272562010227 Walker B; other site 272562010228 D-loop; other site 272562010229 H-loop/switch region; other site 272562010230 Membrane-fusion protein [Cell envelope biogenesis, outer membrane]; Region: AcrA; COG0845 272562010231 Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533 272562010232 HlyD family secretion protein; Region: HlyD_3; pfam13437 272562010233 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 272562010234 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 272562010235 Bacterial surface proteins containing Ig-like domains [Cell motility and secretion]; Region: COG5492 272562010236 Clostridial hydrophobic, with a conserved W residue, domain; Region: ChW; smart00728 272562010237 Clostridial hydrophobic, with a conserved W residue, domain; Region: ChW; smart00728 272562010238 Clostridial hydrophobic, with a conserved W residue, domain; Region: ChW; smart00728 272562010239 Bacterial Ig-like domain (group 2); Region: Big_2; pfam02368 272562010240 Bacterial surface proteins containing Ig-like domains [Cell motility and secretion]; Region: COG5492 272562010241 Clostridial hydrophobic, with a conserved W residue, domain; Region: ChW; smart00728 272562010242 Clostridial hydrophobic, with a conserved W residue, domain; Region: ChW; smart00728 272562010243 Clostridial hydrophobic, with a conserved W residue, domain; Region: ChW; smart00728 272562010244 Bacterial Ig-like domain (group 2); Region: Big_2; pfam02368 272562010245 Leucine rich repeat; Region: LRR_8; pfam13855 272562010246 Leucine Rich repeats (2 copies); Region: LRR_4; pfam12799 272562010247 Leucine rich repeat; Region: LRR_8; pfam13855 272562010248 Leucine Rich repeats (2 copies); Region: LRR_4; pfam12799 272562010249 Leucine Rich repeats (2 copies); Region: LRR_4; pfam12799 272562010250 Bacterial surface proteins containing Ig-like domains [Cell motility and secretion]; Region: COG5492 272562010251 Clostridial hydrophobic, with a conserved W residue, domain; Region: ChW; smart00728 272562010252 Clostridial hydrophobic, with a conserved W residue, domain; Region: ChW; smart00728 272562010253 Clostridial hydrophobic, with a conserved W residue, domain; Region: ChW; smart00728 272562010254 Bacterial Ig-like domain (group 2); Region: Big_2; pfam02368 272562010255 Leucine Rich repeats (2 copies); Region: LRR_4; pfam12799 272562010256 Leucine rich repeat; Region: LRR_8; pfam13855 272562010257 Leucine Rich repeats (2 copies); Region: LRR_4; pfam12799 272562010258 Leucine Rich repeats (2 copies); Region: LRR_4; pfam12799 272562010259 Leucine rich repeat; Region: LRR_8; pfam13855 272562010260 Leucine Rich repeats (2 copies); Region: LRR_4; pfam12799 272562010261 Leucine Rich repeats (2 copies); Region: LRR_4; pfam12799 272562010262 Bacterial surface proteins containing Ig-like domains [Cell motility and secretion]; Region: COG5492 272562010263 Clostridial hydrophobic, with a conserved W residue, domain; Region: ChW; smart00728 272562010264 Clostridial hydrophobic, with a conserved W residue, domain; Region: ChW; smart00728 272562010265 Clostridial hydrophobic, with a conserved W residue, domain; Region: ChW; smart00728 272562010266 Bacterial Ig-like domain (group 2); Region: Big_2; pfam02368 272562010267 Bacterial surface proteins containing Ig-like domains [Cell motility and secretion]; Region: COG5492 272562010268 Clostridial hydrophobic, with a conserved W residue, domain; Region: ChW; smart00728 272562010269 Clostridial hydrophobic, with a conserved W residue, domain; Region: ChW; smart00728 272562010270 Clostridial hydrophobic, with a conserved W residue, domain; Region: ChW; smart00728 272562010271 Bacterial Ig-like domain (group 2); Region: Big_2; pfam02368 272562010272 Leucine-rich repeat (LRR) protein [Function unknown]; Region: COG4886 272562010273 Leucine Rich repeats (2 copies); Region: LRR_4; pfam12799 272562010274 Leucine Rich repeats (2 copies); Region: LRR_4; pfam12799 272562010275 Leucine Rich repeats (2 copies); Region: LRR_4; pfam12799 272562010276 Leucine Rich repeats (2 copies); Region: LRR_4; pfam12799 272562010277 Leucine Rich repeats (2 copies); Region: LRR_4; pfam12799 272562010278 Leucine Rich repeats (2 copies); Region: LRR_4; pfam12799 272562010279 Leucine Rich repeats (2 copies); Region: LRR_4; pfam12799 272562010280 Leucine Rich repeats (2 copies); Region: LRR_4; pfam12799 272562010281 Bacterial surface proteins containing Ig-like domains [Cell motility and secretion]; Region: COG5492 272562010282 Clostridial hydrophobic, with a conserved W residue, domain; Region: ChW; smart00728 272562010283 Clostridial hydrophobic, with a conserved W residue, domain; Region: ChW; smart00728 272562010284 Clostridial hydrophobic, with a conserved W residue, domain; Region: ChW; smart00728 272562010285 Bacterial Ig-like domain (group 2); Region: Big_2; pfam02368 272562010286 Bacterial surface proteins containing Ig-like domains [Cell motility and secretion]; Region: COG5492 272562010287 Clostridial hydrophobic, with a conserved W residue, domain; Region: ChW; smart00728 272562010288 Clostridial hydrophobic, with a conserved W residue, domain; Region: ChW; smart00728 272562010289 Clostridial hydrophobic, with a conserved W residue, domain; Region: ChW; smart00728 272562010290 Bacterial Ig-like domain (group 2); Region: Big_2; pfam02368 272562010291 Bacterial surface proteins containing Ig-like domains [Cell motility and secretion]; Region: COG5492 272562010292 Clostridial hydrophobic, with a conserved W residue, domain; Region: ChW; smart00728 272562010293 Clostridial hydrophobic, with a conserved W residue, domain; Region: ChW; smart00728 272562010294 Bacterial Ig-like domain (group 2); Region: Big_2; pfam02368 272562010295 Bacterial Ig-like domain (group 2); Region: Big_2; pfam02368 272562010296 Bacterial Ig-like domain (group 2); Region: Big_2; pfam02368 272562010297 Leucine rich repeat; Region: LRR_8; pfam13855 272562010298 Leucine Rich repeats (2 copies); Region: LRR_4; pfam12799 272562010299 Leucine Rich repeats (2 copies); Region: LRR_4; pfam12799 272562010300 Ribonucleotide Reductase, R2/beta subunit, ferritin-like diiron-binding domain; Region: RNRR2; cd01049 272562010301 dimer interface [polypeptide binding]; other site 272562010302 putative radical transfer pathway; other site 272562010303 diiron center [ion binding]; other site 272562010304 tyrosyl radical; other site 272562010305 ribonucleotide-diphosphate reductase subunit alpha; Validated; Region: PRK07088 272562010306 Class I ribonucleotide reductase; Region: RNR_I; cd01679 272562010307 active site 272562010308 dimer interface [polypeptide binding]; other site 272562010309 catalytic residues [active] 272562010310 effector binding site; other site 272562010311 R2 peptide binding site; other site 272562010312 Bacterial surface proteins containing Ig-like domains [Cell motility and secretion]; Region: COG5492 272562010313 Clostridial hydrophobic, with a conserved W residue, domain; Region: ChW; smart00728 272562010314 Clostridial hydrophobic, with a conserved W residue, domain; Region: ChW; smart00728 272562010315 Clostridial hydrophobic, with a conserved W residue, domain; Region: ChW; smart00728 272562010316 Bacterial Ig-like domain (group 2); Region: Big_2; pfam02368 272562010317 Bacterial surface proteins containing Ig-like domains [Cell motility and secretion]; Region: COG5492 272562010318 Clostridial hydrophobic, with a conserved W residue, domain; Region: ChW; smart00728 272562010319 Clostridial hydrophobic, with a conserved W residue, domain; Region: ChW; smart00728 272562010320 Clostridial hydrophobic, with a conserved W residue, domain; Region: ChW; smart00728 272562010321 Bacterial Ig-like domain (group 2); Region: Big_2; pfam02368 272562010322 Bacterial surface proteins containing Ig-like domains [Cell motility and secretion]; Region: COG5492 272562010323 Clostridial hydrophobic, with a conserved W residue, domain; Region: ChW; smart00728 272562010324 Clostridial hydrophobic, with a conserved W residue, domain; Region: ChW; smart00728 272562010325 Clostridial hydrophobic, with a conserved W residue, domain; Region: ChW; smart00728 272562010326 Bacterial Ig-like domain (group 2); Region: Big_2; pfam02368 272562010327 Leucine-rich repeat (LRR) protein [Function unknown]; Region: COG4886 272562010328 Leucine Rich repeats (2 copies); Region: LRR_4; pfam12799 272562010329 Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 residue sequence motifs present in many proteins that participate in protein-protein interactions and have different functions and cellular locations. LRRs correspond...; Region: LRR_RI; cd00116 272562010330 Leucine Rich repeats (2 copies); Region: LRR_4; pfam12799 272562010331 Leucine-rich repeats; other site 272562010332 Substrate binding site [chemical binding]; other site 272562010333 Leucine Rich repeats (2 copies); Region: LRR_4; pfam12799 272562010334 Bacterial surface proteins containing Ig-like domains [Cell motility and secretion]; Region: COG5492 272562010335 Clostridial hydrophobic, with a conserved W residue, domain; Region: ChW; smart00728 272562010336 Clostridial hydrophobic, with a conserved W residue, domain; Region: ChW; smart00728 272562010337 Clostridial hydrophobic, with a conserved W residue, domain; Region: ChW; smart00728 272562010338 Bacterial Ig-like domain (group 2); Region: Big_2; pfam02368 272562010339 Bacterial surface proteins containing Ig-like domains [Cell motility and secretion]; Region: COG5492 272562010340 Clostridial hydrophobic, with a conserved W residue, domain; Region: ChW; smart00728 272562010341 Clostridial hydrophobic, with a conserved W residue, domain; Region: ChW; smart00728 272562010342 Clostridial hydrophobic, with a conserved W residue, domain; Region: ChW; smart00728 272562010343 Bacterial Ig-like domain (group 2); Region: Big_2; pfam02368 272562010344 Leucine-rich repeat (LRR) protein [Function unknown]; Region: COG4886 272562010345 Leucine Rich repeats (2 copies); Region: LRR_4; pfam12799 272562010346 Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 residue sequence motifs present in many proteins that participate in protein-protein interactions and have different functions and cellular locations. LRRs correspond...; Region: LRR_RI; cd00116 272562010347 Leucine-rich repeats; other site 272562010348 Substrate binding site [chemical binding]; other site 272562010349 Leucine Rich repeats (2 copies); Region: LRR_4; pfam12799 272562010350 Leucine Rich repeats (2 copies); Region: LRR_4; pfam12799 272562010351 Acetyltransferase (GNAT) domain; Region: Acetyltransf_6; cl19151 272562010352 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 272562010353 ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132 272562010354 ATP-binding cassette domain of glucan transporter and related proteins, subfamily C; Region: ABCC_Glucan_exporter_like; cd03254 272562010355 Walker A/P-loop; other site 272562010356 ATP binding site [chemical binding]; other site 272562010357 Q-loop/lid; other site 272562010358 ABC transporter signature motif; other site 272562010359 Walker B; other site 272562010360 D-loop; other site 272562010361 H-loop/switch region; other site 272562010362 ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132 272562010363 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 272562010364 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 272562010365 Walker A/P-loop; other site 272562010366 ATP binding site [chemical binding]; other site 272562010367 Q-loop/lid; other site 272562010368 ABC transporter signature motif; other site 272562010369 Walker B; other site 272562010370 D-loop; other site 272562010371 H-loop/switch region; other site 272562010372 Transcriptional regulators [Transcription]; Region: MarR; COG1846 272562010373 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 272562010374 dimerization interface [polypeptide binding]; other site 272562010375 putative Zn2+ binding site [ion binding]; other site 272562010376 putative DNA binding site [nucleotide binding]; other site 272562010377 EDD domain protein, DegV family; Region: DegV; TIGR00762 272562010378 amino acid transporter; Region: 2A0306; TIGR00909 272562010379 Transmembrane amino acid transporter protein; Region: Aa_trans; cl17468 272562010380 C-terminus of AA_permease; Region: AA_permease_C; pfam13906 272562010381 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 272562010382 active site 272562010383 phosphorylation site [posttranslational modification] 272562010384 intermolecular recognition site; other site 272562010385 dimerization interface [polypeptide binding]; other site 272562010386 YcbB domain; Region: YcbB; pfam08664 272562010387 FeS assembly ATPase SufC; Region: sufC; TIGR01978 272562010388 ABC-type transport system involved in Fe-S cluster assembly, ATPase component; Region: ABC_FeS_Assembly; cd03217 272562010389 Walker A/P-loop; other site 272562010390 ATP binding site [chemical binding]; other site 272562010391 Q-loop/lid; other site 272562010392 ABC transporter signature motif; other site 272562010393 Walker B; other site 272562010394 D-loop; other site 272562010395 H-loop/switch region; other site 272562010396 FeS assembly protein SufB; Region: sufB; TIGR01980 272562010397 Uncharacterized protein family (UPF0051); Region: UPF0051; pfam01458 272562010398 FeS assembly protein SufD; Region: sufD; TIGR01981 272562010399 Cysteine desulfurase activator SufB [Posttranslational modification, protein turnover, chaperones]; Region: SufB; COG0719 272562010400 Cysteine desulfurase (SufS)-like. This family belongs to the pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to cysteine desulfurase (SufS) and selenocysteine lyase. SufS...; Region: SufS_like; cd06453 272562010401 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 272562010402 catalytic residue [active] 272562010403 Iron-sulfur cluster scaffold-like proteins; Region: IscU_like; cd06664 272562010404 trimerization site [polypeptide binding]; other site 272562010405 active site 272562010406 Lipid A core - O-antigen ligase and related enzymes [Cell envelope biogenesis, outer membrane]; Region: RfaL; COG3307 272562010407 O-Antigen ligase; Region: Wzy_C; pfam04932 272562010408 Subfamily of the multidrug and toxic compound extrusion (MATE)-like proteins similar to Streptococcus aureus MepA; Region: MATE_MepA_like; cd13143 272562010409 Na+-driven multidrug efflux pump [Defense mechanisms]; Region: NorM; COG0534 272562010410 AraC-like ligand binding domain; Region: AraC_binding; pfam02311 272562010411 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 272562010412 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 272562010413 Beta-xylosidase [Carbohydrate transport and metabolism]; Region: XynB; COG3664 272562010414 D-alanyl-D-alanine carboxypeptidase [Cell envelope biogenesis, outer membrane]; Region: VanY; COG1876 272562010415 D-alanyl-D-alanine carboxypeptidase; Region: VanY; pfam02557 272562010416 Butanol dehydrogenase catalyzes the conversion of butyraldehyde to butanol with the cofactor NAD(P)H being oxidized in the process; Region: BDH; cd08187 272562010417 dimer interface [polypeptide binding]; other site 272562010418 active site 272562010419 metal binding site [ion binding]; metal-binding site 272562010420 Butanol dehydrogenase catalyzes the conversion of butyraldehyde to butanol with the cofactor NAD(P)H being oxidized in the process; Region: BDH; cd08187 272562010421 dimer interface [polypeptide binding]; other site 272562010422 active site 272562010423 metal binding site [ion binding]; metal-binding site 272562010424 Bacillus/Clostridium GerA spore germination protein; Region: GerA; pfam03323 272562010425 Spore germination protein; Region: Spore_permease; pfam03845 272562010426 germination protein, Ger(x)C family; Region: spore_ger_x_C; TIGR02887 272562010427 Bacterial SNF2 helicase associated; Region: SNF2_assoc; pfam08455 272562010428 SNF2 family N-terminal domain; Region: SNF2_N; pfam00176 272562010429 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 272562010430 ATP binding site [chemical binding]; other site 272562010431 putative Mg++ binding site [ion binding]; other site 272562010432 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 272562010433 nucleotide binding region [chemical binding]; other site 272562010434 ATP-binding site [chemical binding]; other site 272562010435 Peroxiredoxin (PRX) family, Atypical 2-cys PRX subfamily; composed of PRXs containing peroxidatic and resolving cysteines, similar to the homodimeric thiol specific antioxidant (TSA) protein also known as TRX-dependent thiol peroxidase (Tpx). Tpx is a...; Region: PRX_Atyp2cys; cd03014 272562010436 dimer interface [polypeptide binding]; other site 272562010437 catalytic triad [active] 272562010438 peroxidatic and resolving cysteines [active] 272562010439 putative PEP-CTERM system TPR-repeat lipoprotein; Region: PEP_TPR_lipo; TIGR02917 272562010440 UDP-glucose LOS-beta-1,4 glucosyltransferase is required for biosynthesis of lipooligosaccharide; Region: Beta4Glucosyltransferase; cd02511 272562010441 putative metal binding site; other site 272562010442 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 272562010443 TPR motif; other site 272562010444 binding surface 272562010445 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 272562010446 TPR motif; other site 272562010447 binding surface 272562010448 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 272562010449 binding surface 272562010450 TPR motif; other site 272562010451 hypothetical protein; Provisional; Region: PRK09946 272562010452 UDP-N-acetyl-D-mannosaminuronate dehydrogenase [Cell envelope biogenesis, outer membrane]; Region: WecC; COG0677 272562010453 UDP-glucose/GDP-mannose dehydrogenase family, NAD binding domain; Region: UDPG_MGDP_dh_N; pfam03721 272562010454 UDP-glucose/GDP-mannose dehydrogenase family, central domain; Region: UDPG_MGDP_dh; pfam00984 272562010455 UDP-glucose/GDP-mannose dehydrogenase family, UDP binding domain; Region: UDPG_MGDP_dh_C; pfam03720 272562010456 Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013 272562010457 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 272562010458 Predicted enzyme involved in methoxymalonyl-ACP biosynthesis [Secondary metabolites biosynthesis, transport, and catabolism]; Region: FkbH; COG3882 272562010459 Acid Phosphatase; Region: Acid_PPase; cl17256 272562010460 Acyl carrier protein [Lipid metabolism / Secondary metabolites biosynthesis, transport, and catabolism]; Region: AcpP; COG0236 272562010461 Nitroreductase-like family 4. A subfamily of the nitroreductase family containing uncharacterized proteins that are similar to nitroreductase. Nitroreductase catalyzes the reduction of nitroaromatic compounds such as nitrotoluenes, nitrofurans and...; Region: Nitroreductase_4; cd02140 272562010462 dimer interface [polypeptide binding]; other site 272562010463 FMN binding site [chemical binding]; other site 272562010464 heat shock protein 90; Provisional; Region: PRK05218 272562010465 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 272562010466 ATP binding site [chemical binding]; other site 272562010467 Mg2+ binding site [ion binding]; other site 272562010468 G-X-G motif; other site 272562010469 Hsp90 protein; Region: HSP90; pfam00183 272562010470 Phospholipase_D-nuclease N-terminal; Region: PLDc_N; pfam13396 272562010471 Phosphatidylserine/phosphatidylglycerophosphate/car diolipin synthases and related enzymes [Lipid metabolism]; Region: Cls; COG1502 272562010472 Putative catalytic domain, repeat 1, of Streptococcus mutans uncharacterized protein SMU_988 and similar proteins; Region: PLDc_SMU_988_like_1; cd09154 272562010473 putative active site [active] 272562010474 catalytic site [active] 272562010475 Putative catalytic domain, repeat 2, of Streptococcus mutans uncharacterized protein SMU_988 and similar proteins; Region: PLDc_SMU_988_like_2; cd09160 272562010476 putative active site [active] 272562010477 catalytic site [active] 272562010478 Spore coat protein [Cell envelope biogenesis, outer membrane]; Region: COG5577 272562010479 Transcriptional activator of acetoin/glycerol metabolism [Secondary metabolites biosynthesis, transport, and catabolism / Transcription]; Region: AcoR; COG3284 272562010480 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 272562010481 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 272562010482 dimer interface [polypeptide binding]; other site 272562010483 phosphorylation site [posttranslational modification] 272562010484 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 272562010485 ATP binding site [chemical binding]; other site 272562010486 Mg2+ binding site [ion binding]; other site 272562010487 G-X-G motif; other site 272562010488 Putative amidase domain; Region: Amidase_6; pfam12671 272562010489 hypothetical protein; Provisional; Region: PRK00872 272562010490 Acetyltransferase (GNAT) domain; Region: Acetyltransf_3; pfam13302 272562010491 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 272562010492 non-specific DNA binding site [nucleotide binding]; other site 272562010493 salt bridge; other site 272562010494 sequence-specific DNA binding site [nucleotide binding]; other site 272562010495 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 272562010496 Bacterial extracellular solute-binding proteins, family 3; Region: SBP_bac_3; pfam00497 272562010497 substrate binding pocket [chemical binding]; other site 272562010498 membrane-bound complex binding site; other site 272562010499 hinge residues; other site 272562010500 ABC-type amino acid transport system, permease component [Amino acid transport and metabolism]; Region: HisM; COG0765 272562010501 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 272562010502 dimer interface [polypeptide binding]; other site 272562010503 conserved gate region; other site 272562010504 putative PBP binding loops; other site 272562010505 ABC-ATPase subunit interface; other site 272562010506 ABC-type polar amino acid transport system, ATPase component [Amino acid transport and metabolism]; Region: GlnQ; COG1126 272562010507 ATP-binding cassette domain of the histidine and glutamine transporters; Region: ABC_HisP_GlnQ; cd03262 272562010508 Walker A/P-loop; other site 272562010509 ATP binding site [chemical binding]; other site 272562010510 Q-loop/lid; other site 272562010511 ABC transporter signature motif; other site 272562010512 Walker B; other site 272562010513 D-loop; other site 272562010514 H-loop/switch region; other site 272562010515 Mn2+ and Fe2+ transporters of the NRAMP family [Inorganic ion transport and metabolism]; Region: MntH; COG1914 272562010516 Natural resistance-associated macrophage protein; Region: Nramp; pfam01566 272562010517 Cytochrome P450 [Secondary metabolites biosynthesis, transport, and catabolism]; Region: CypX; COG2124 272562010518 Alanine racemase [Cell envelope biogenesis, outer membrane]; Region: Alr; COG0787 272562010519 Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzyme Alanine Racemase; Region: PLPDE_III_AR; cd00430 272562010520 active site 272562010521 pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site 272562010522 dimer interface [polypeptide binding]; other site 272562010523 substrate binding site [chemical binding]; other site 272562010524 catalytic residues [active] 272562010525 Imidazolonepropionase and related amidohydrolases [Secondary metabolites biosynthesis, transport, and catabolism]; Region: HutI; COG1228 272562010526 Metallo-dependent hydrolases, subgroup C is part of the superfamily of metallo-dependent hydrolases, a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the...; Region: Met_dep_hydrolase_C; cd01309 272562010527 active site 272562010528 Uncharacterized conserved protein related to pyruvate formate-lyase activating enzyme [General function prediction only]; Region: COG2108 272562010529 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 272562010530 FeS/SAM binding site; other site 272562010531 Multimeric flavodoxin WrbA [General function prediction only]; Region: WrbA; COG0655 272562010532 17beta hydroxysteroid dehydrogenase-like, classical (c) SDRs; Region: 17beta-HSD-like_SDR_c; cd05374 272562010533 short chain dehydrogenase; Provisional; Region: PRK09291 272562010534 NADP binding site [chemical binding]; other site 272562010535 active site 272562010536 steroid binding site; other site 272562010537 cAMP-binding proteins - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases [Signal transduction mechanisms]; Region: Crp; COG0664 272562010538 effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038 272562010539 ligand binding site [chemical binding]; other site 272562010540 flexible hinge region; other site 272562010541 Predicted metal-dependent hydrolase of the TIM-barrel fold [General function prediction only]; Region: COG2159 272562010542 Predicted transcriptional regulators [Transcription]; Region: COG1733 272562010543 ATPase components of ABC transporters with duplicated ATPase domains [General function prediction only]; Region: Uup; COG0488 272562010544 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 272562010545 ABC transporter; Region: ABC_tran_2; pfam12848 272562010546 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 272562010547 Nucleotidyltransferase (NT) domain of RelA- and SpoT-like ppGpp synthetases and hydrolases; Region: NT_Rel-Spo_like; cd05399 272562010548 synthetase active site [active] 272562010549 NTP binding site [chemical binding]; other site 272562010550 metal binding site [ion binding]; metal-binding site 272562010551 Multimeric flavodoxin WrbA [General function prediction only]; Region: WrbA; COG0655 272562010552 3-hydroxyisobutyrate dehydrogenase and related beta-hydroxyacid dehydrogenases [Lipid metabolism]; Region: MmsB; COG2084 272562010553 NAD binding domain of 6-phosphogluconate dehydrogenase; Region: NAD_binding_2; pfam03446 272562010554 NAD-binding of NADP-dependent 3-hydroxyisobutyrate dehydrogenase; Region: NAD_binding_11; pfam14833 272562010555 putative DNA modification/repair radical SAM protein; Region: rSAM_link_UDG; TIGR03916 272562010556 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 272562010557 FeS/SAM binding site; other site 272562010558 endonuclease III; includes endonuclease III (DNA-(apurinic or apyrimidinic site) lyase), alkylbase DNA glycosidases (Alka-family) and other DNA glycosidases; Region: ENDO3c; cl19066 272562010559 probable DNA metabolism protein; Region: SAM_7_link_chp; TIGR03915 272562010560 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 272562010561 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 272562010562 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 272562010563 putative transporter; Provisional; Region: PRK10504 272562010564 putative substrate translocation pore; other site 272562010565 lysine transporter; Provisional; Region: PRK10836 272562010566 Transmembrane amino acid transporter protein; Region: Aa_trans; cl17468 272562010567 homocysteine methyltransferase; Provisional; Region: mmuM; PRK09485 272562010568 Transcriptional regulator [Transcription]; Region: LysR; COG0583 272562010569 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 272562010570 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cd05466 272562010571 dimerization interface [polypeptide binding]; other site 272562010572 Putative intracellular protease/amidase [General function prediction only]; Region: ThiJ; COG0693 272562010573 Type 1 glutamine amidotransferase (GATase1)-like domain found in Human DJ-1; Region: GATase1_DJ-1; cd03135 272562010574 conserved cys residue [active] 272562010575 Protein of unknown function (DUF2512); Region: DUF2512; pfam10710 272562010576 Cache domain; Region: Cache_1; pfam02743 272562010577 Methyl-accepting chemotaxis protein [Cell motility and secretion / Signal transduction mechanisms]; Region: Tar; COG0840 272562010578 HAMP domain; Region: HAMP; pfam00672 272562010579 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cl19050 272562010580 dimer interface [polypeptide binding]; other site 272562010581 putative CheW interface [polypeptide binding]; other site 272562010582 Subfamily of the multidrug and toxic compound extrusion (MATE)-like proteins similar to Bacillus subtilis yoeA; Region: MATE_yoeA_like; cd13138 272562010583 Na+-driven multidrug efflux pump [Defense mechanisms]; Region: NorM; COG0534 272562010584 Polyketide synthase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG3321 272562010585 polyketide synthases (PKSs) polymerize simple fatty acids into a large variety of different products, called polyketides, by successive decarboxylating Claisen condensations. PKSs can be divided into 2 groups, modular type I PKSs consisting of one or...; Region: PKS; cd00833 272562010586 active site 272562010587 Acyl transferase domain in polyketide synthase (PKS) enzymes; Region: PKS_AT; smart00827 272562010588 Polyketide synthase dehydratase; Region: PS-DH; pfam14765 272562010589 beta-ketoacyl reductase (KR) domain of fatty acid synthase (FAS), subgroup 2, complex (x); Region: KR_2_FAS_SDR_x; cd08955 272562010590 short chain dehydrogenase; Region: adh_short; pfam00106 272562010591 putative NADP binding site [chemical binding]; other site 272562010592 active site 272562010593 Phosphopantetheine attachment site; Region: PP-binding; pfam00550 272562010594 This domain superfamily is found in a variety of structurally related metalloproteins, including the type I extradiol dioxygenases, glyoxalase I and a group of antibiotic resistance proteins; Region: Glo_EDI_BRP_like; cd06587 272562010595 active site 272562010596 Site-specific DNA methylase [DNA replication, recombination, and repair]; Region: Dam; COG0338 272562010597 The HCP family of iron-sulfur proteins includes hybrid cluster protein (HCP), acetyl-CoA synthase (ACS), and carbon monoxide dehydrogenase (CODH), all of which contain [Fe4-S4] metal clusters at their active sites. These proteins have a conserved...; Region: HCP_like; cl19102 272562010598 4Fe-4S dicluster domain; Region: Fer4_10; pfam13237 272562010599 Ferredoxin [Energy production and conversion]; Region: NapF; COG1145 272562010600 Proteins of this family catalyze the reduction of flavin or nitrocompounds using NAD(P)H as electron donor in a obligatory two-electron transfer, utilizing FMN or FAD as cofactor. They are often found to be homodimers. Enzymes of this family are...; Region: Nitro_FMN_reductase; cl00514 272562010601 FMN binding site [chemical binding]; other site 272562010602 dimer interface [polypeptide binding]; other site 272562010603 Transcriptional regulator [Transcription]; Region: LysR; COG0583 272562010604 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 272562010605 The substrate binding domain of LysR-type transcriptional regulator GltC, which activates gltA expression of glutamate synthase operon, contains type 2 periplasmic binding fold; Region: PBP2_GltC_like; cd08434 272562010606 putative dimerization interface [polypeptide binding]; other site 272562010607 Transcriptional regulator [Transcription]; Region: LysR; COG0583 272562010608 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 272562010609 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cd05466 272562010610 dimerization interface [polypeptide binding]; other site 272562010611 Predicted membrane protein [Function unknown]; Region: COG3619 272562010612 Barstar_SaI14_like contains sequences that are similar to SaI14, an RNAase inhibitor, which are members of the Barstar family. Barstar is an intracellular inhibitor of barnase, an extracellular ribonuclease of Bacillus amyloliquefaciens. Barstar binds...; Region: Barstar_SaI14_like; cd05143 272562010613 putative RNAase interaction site [polypeptide binding]; other site 272562010614 legume lectins; Region: lectin_L-type; cl14058 272562010615 metal binding site [ion binding]; metal-binding site 272562010616 chaperonin_like superfamily. Chaperonins are involved in productive folding of proteins. They share a common general morphology, a double toroid of 2 stacked rings, each composed of 7-9 subunits. There are 2 main chaperonin groups. The symmetry of type I...; Region: chaperonin_like; cl02777 272562010617 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 272562010618 Major Facilitator Superfamily; Region: MFS_1; pfam07690 272562010619 putative substrate translocation pore; other site 272562010620 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 272562010621 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 272562010622 Predicted transcriptional regulators [Transcription]; Region: COG1695 272562010623 Virulence activator alpha C-term; Region: Vir_act_alpha_C; pfam10400 272562010624 mycofactocin system FadH/OYE family oxidoreductase 2; Region: mycofact_OYE_2; TIGR03997 272562010625 Enoate reductase (ER)-like FMN-binding domain. Enoate reductase catalyzes the NADH-dependent reduction of carbon-carbon double bonds of several molecules, including nonactivated 2-enoates, alpha,beta-unsaturated aldehydes, cyclic ketones, and...; Region: ER_like_FMN; cd02931 272562010626 putative active site [active] 272562010627 putative FMN binding site [chemical binding]; other site 272562010628 putative substrate binding site [chemical binding]; other site 272562010629 putative catalytic residue [active] 272562010630 putative 4Fe-4S cluster binding site [ion binding]; other site 272562010631 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 272562010632 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 272562010633 Predicted membrane protein [Function unknown]; Region: COG2323 272562010634 Pectin methylesterase [Carbohydrate transport and metabolism]; Region: PemB; COG4677 272562010635 Pectinesterase; Region: Pectinesterase; cl01911 272562010636 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 272562010637 Acetyltransferases [General function prediction only]; Region: RimI; COG0456 272562010638 Coenzyme A binding pocket [chemical binding]; other site 272562010639 Glutathione-dependent formaldehyde dehydrogenase related proteins, child 1; Region: FDH_like_1; cd08283 272562010640 Threonine dehydrogenase and related Zn-dependent dehydrogenases [Amino acid transport and metabolism / General function prediction only]; Region: Tdh; COG1063 272562010641 NAD binding site [chemical binding]; other site 272562010642 catalytic Zn binding site [ion binding]; other site 272562010643 structural Zn binding site [ion binding]; other site 272562010644 Uncharacterized conserved protein, contains double-stranded beta-helix domain [Function unknown]; Region: COG1917 272562010645 Predicted xylanase/chitin deacetylase [Carbohydrate transport and metabolism]; Region: CDA1; COG0726 272562010646 Catalytic NodB homology domain of Streptococcus mutans polysaccharide deacetylase PgdA, Bacillus subtilis YheN, and similar proteins; Region: CE4_SmPgdA_like; cd10944 272562010647 NodB motif; other site 272562010648 active site 272562010649 catalytic site [active] 272562010650 Zn binding site [ion binding]; other site 272562010651 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 272562010652 voltage-dependent potassium channel beta subunit, animal; Region: Kv_beta; TIGR01293 272562010653 active site 272562010654 catalytic tetrad [active] 272562010655 Uncharacterized conserved protein [Function unknown]; Region: COG5663 272562010656 Metallo-beta-lactamase superfamily; Region: Lactamase_B; smart00849 272562010657 Uncharacterized prokaryotic subgroup of the stomatin-like proteins (slipins) family; belonging to the SPFH (stomatin, prohibitin, flotillin, and HflK/C) superfamily; Region: SPFH_eoslipins_u2; cd13438 272562010658 prohibitin homologues; Region: PHB; smart00244 272562010659 Uncharacterized conserved protein [Function unknown]; Region: RtcB; COG1690 272562010660 tRNA-splicing ligase RtcB; Region: RtcB; pfam01139 272562010661 release factor H-coupled RctB family protein; Region: release_rtcB; TIGR03073 272562010662 tRNA-splicing ligase RtcB; Region: RtcB; pfam01139 272562010663 putative peptide chain release factor H; Region: release_prfH; TIGR03072 272562010664 peptide chain release factor-like protein; Reviewed; Region: prfH; PRK08179 272562010665 WYL domain; Region: WYL; pfam13280 272562010666 family 29 and family 65 carbohydrate binding modules; Region: CBM29_CBM65; cd13748 272562010667 WYL domain; Region: WYL; pfam13280 272562010668 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cl19050 272562010669 dimer interface [polypeptide binding]; other site 272562010670 putative CheW interface [polypeptide binding]; other site 272562010671 Phage shock protein A (IM30), suppresses sigma54-dependent transcription [Transcription / Signal transduction mechanisms]; Region: PspA; COG1842 272562010672 Response regulator containing CheY-like receiver and SARP domains [Signal transduction mechanisms]; Region: COG3947 272562010673 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 272562010674 active site 272562010675 phosphorylation site [posttranslational modification] 272562010676 intermolecular recognition site; other site 272562010677 dimerization interface [polypeptide binding]; other site 272562010678 Transcriptional regulatory protein, C terminal; Region: Trans_reg_C; pfam00486 272562010679 PAS domain; Region: PAS_9; pfam13426 272562010680 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 272562010681 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 272562010682 dimer interface [polypeptide binding]; other site 272562010683 phosphorylation site [posttranslational modification] 272562010684 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 272562010685 ATP binding site [chemical binding]; other site 272562010686 Mg2+ binding site [ion binding]; other site 272562010687 G-X-G motif; other site 272562010688 Butanol dehydrogenase catalyzes the conversion of butyraldehyde to butanol with the cofactor NAD(P)H being oxidized in the process; Region: BDH; cd08187 272562010689 dimer interface [polypeptide binding]; other site 272562010690 active site 272562010691 metal binding site [ion binding]; metal-binding site 272562010692 Uncharacterized conserved protein [Function unknown]; Region: COG1359 272562010693 NTP pyrophosphohydrolases containing a Zn-finger, probably nucleic-acid-binding [DNA replication, recombination, and repair]; Region: NPY1; COG2816 272562010694 NADH pyrophosphatase-like rudimentary NUDIX domain; Region: NUDIX-like; pfam09296 272562010695 NADH pyrophosphatase zinc ribbon domain; Region: zf-NADH-PPase; pfam09297 272562010696 NADH pyrophosphatase, a member of the Nudix hydrolase superfamily, catalyzes the cleavage of NADH into reduced nicotinamide mononucleotide (NMNH) and AMP. Like other members of the Nudix family, it requires a divalent cation, such as Mg2+ or Mn2+, for...; Region: NADH_pyrophosphatase; cd03429 272562010697 putative NADH binding site [chemical binding]; other site 272562010698 putative active site [active] 272562010699 nudix motif; other site 272562010700 putative metal binding site [ion binding]; other site 272562010701 ligand binding domain of Tar- and Tsr-related chemoreceptors; Region: Tar_Tsr_LBD; cl00144 272562010702 Methyl-accepting chemotaxis protein [Cell motility and secretion / Signal transduction mechanisms]; Region: Tar; COG0840 272562010703 HAMP domain; Region: HAMP; pfam00672 272562010704 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cl19050 272562010705 dimer interface [polypeptide binding]; other site 272562010706 putative CheW interface [polypeptide binding]; other site 272562010707 PhosphatidylEthanolamine-Binding Protein (PEBP) domain present in bacteria and archaea; Region: PEBP_bact_arch; cd00865 272562010708 substrate binding site [chemical binding]; other site 272562010709 Predicted transcriptional regulators [Transcription]; Region: COG1733 272562010710 Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673 272562010711 Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408 272562010712 Oxidoreductase family, C-terminal alpha/beta domain; Region: GFO_IDH_MocA_C; pfam02894 272562010713 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 272562010714 Prolyl oligopeptidase family; Region: Peptidase_S9; cl19144 272562010715 ABC-type multidrug transport system, permease component [Defense mechanisms]; Region: COG0842 272562010716 ABC-2 type transporter; Region: ABC2_membrane; pfam01061 272562010717 ABC-2 family transporter protein; Region: ABC2_membrane_3; pfam12698 272562010718 ABC-type multidrug transport system, ATPase component [Defense mechanisms]; Region: CcmA; COG1131 272562010719 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 272562010720 Walker A/P-loop; other site 272562010721 ATP binding site [chemical binding]; other site 272562010722 Q-loop/lid; other site 272562010723 ABC transporter signature motif; other site 272562010724 Walker B; other site 272562010725 D-loop; other site 272562010726 H-loop/switch region; other site 272562010727 Transcriptional regulators [Transcription]; Region: MarR; COG1846 272562010728 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cl17220 272562010729 Acyl-CoA thioester hydrolase/BAAT N-terminal region; Region: Bile_Hydr_Trans; pfam04775 272562010730 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 272562010731 BAAT / Acyl-CoA thioester hydrolase C terminal; Region: BAAT_C; pfam08840 272562010732 mycofactocin system FadH/OYE family oxidoreductase 2; Region: mycofact_OYE_2; TIGR03997 272562010733 Old yellow enzyme (OYE)-like FMN binding domain. OYE was the first flavin-dependent enzyme identified, however its true physiological role remains elusive to this day. Each monomer of OYE contains FMN as a non-covalently bound cofactor, uses NADPH as a...; Region: OYE_like_FMN_family; cd02803 272562010734 active site 272562010735 FMN binding site [chemical binding]; other site 272562010736 substrate binding site [chemical binding]; other site 272562010737 putative catalytic residue [active] 272562010738 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl19134 272562010739 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 272562010740 Transcriptional regulator [Transcription]; Region: LysR; COG0583 272562010741 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 272562010742 The C-terminal substrate binding domain of LysR-type transcriptional regulators involved in the catabolism of aromatic compounds and that of other related regulators, contains type 2 periplasmic binding fold; Region: PBP2_LTTR_aromatics_like; cd08414 272562010743 dimerization interface [polypeptide binding]; other site 272562010744 substrate binding pocket [chemical binding]; other site 272562010745 c-di-GMP phosphodiesterase class II (HD-GYP domain) [Signal transduction mechanisms]; Region: COG2206 272562010746 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 272562010747 Zn2+ binding site [ion binding]; other site 272562010748 Mg2+ binding site [ion binding]; other site 272562010749 GH3 auxin-responsive promoter; Region: GH3; pfam03321 272562010750 indole-3-acetic acid-amido synthetase; Region: PLN02620 272562010751 Putative protein-S-isoprenylcysteine methyltransferase [Posttranslational modification, protein turnover, chaperones]; Region: STE14; COG2020 272562010752 Transcriptional regulators [Transcription]; Region: MarR; COG1846 272562010753 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cl17220 272562010754 ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132 272562010755 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 272562010756 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 272562010757 Walker A/P-loop; other site 272562010758 ATP binding site [chemical binding]; other site 272562010759 Q-loop/lid; other site 272562010760 ABC transporter signature motif; other site 272562010761 Walker B; other site 272562010762 D-loop; other site 272562010763 H-loop/switch region; other site 272562010764 ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132 272562010765 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 272562010766 ATP-binding cassette domain of glucan transporter and related proteins, subfamily C; Region: ABCC_Glucan_exporter_like; cd03254 272562010767 Walker A/P-loop; other site 272562010768 ATP binding site [chemical binding]; other site 272562010769 Q-loop/lid; other site 272562010770 ABC transporter signature motif; other site 272562010771 Walker B; other site 272562010772 D-loop; other site 272562010773 H-loop/switch region; other site 272562010774 Staygreen protein; Region: Staygreen; pfam12638 272562010775 NADPH-dependent FMN reductase; Region: FMN_red; cl00438 272562010776 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cl17220 272562010777 Transcriptional regulators [Transcription]; Region: MarR; COG1846 272562010778 Methyltransferase domain; Region: Methyltransf_31; pfam13847 272562010779 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 272562010780 S-adenosylmethionine binding site [chemical binding]; other site 272562010781 Threonine aldolase [Amino acid transport and metabolism]; Region: GLY1; COG2008 272562010782 Beta-eliminating lyase; Region: Beta_elim_lyase; pfam01212 272562010783 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 272562010784 catalytic residue [active] 272562010785 Acyl carrier protein phosphodiesterase [Lipid metabolism]; Region: AcpD; COG1182 272562010786 Na+/melibiose symporter and related transporters [Carbohydrate transport and metabolism]; Region: MelB; COG2211 272562010787 putative symporter YagG; Provisional; Region: PRK09669; cl15392 272562010788 Acetyltransferase (GNAT) domain; Region: Acetyltransf_3; pfam13302 272562010789 Acetyltransferase (GNAT) family; Region: Acetyltransf_1; pfam00583 272562010790 Transcriptional regulators [Transcription]; Region: RpiR; COG1737 272562010791 Helix-turn-helix domain, rpiR family; Region: HTH_6; pfam01418 272562010792 SIS domain. SIS (Sugar ISomerase) domains are found in many phosphosugar isomerases and phosphosugar binding proteins. SIS domains are also found in proteins that regulate the expression of genes involved in synthesis of phosphosugars; Region: SIS; cl00389 272562010793 Phosphotransferase system IIC components, glucose/maltose/N-acetylglucosamine-specific [Carbohydrate transport and metabolism]; Region: PtsG; COG1263 272562010794 PTS system, alpha-glucoside-specific IIBC component; Region: PTS-IIBC-alpha; TIGR02005 272562010795 PTS_IIB, PTS system, glucose/sucrose specific IIB subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIB_glc; cd00212 272562010796 active site turn [active] 272562010797 phosphorylation site [posttranslational modification] 272562010798 Alpha-galactosidases/6-phospho-beta-glucosidases, family 4 of glycosyl hydrolases [Carbohydrate transport and metabolism]; Region: CelF; COG1486 272562010799 Glycoside Hydrolases Family 4; GlvA- and pagL-like glycosidases; Region: GH4_GlvA_pagL_like; cd05298 272562010800 NAD binding site [chemical binding]; other site 272562010801 sugar binding site [chemical binding]; other site 272562010802 divalent metal binding site [ion binding]; other site 272562010803 putative tetramer (dimer of dimers) interface [polypeptide binding]; other site 272562010804 dimer interface [polypeptide binding]; other site 272562010805 Phosphotransferase system IIA components [Carbohydrate transport and metabolism]; Region: NagE; COG2190 272562010806 HPr interaction site; other site 272562010807 glycerol kinase (GK) interaction site [polypeptide binding]; other site 272562010808 active site 272562010809 phosphorylation site [posttranslational modification] 272562010810 Hybrid cluster protein (HCP), formerly known as prismane, is thought to play a role in nitrogen metabolism but its specific function is unknown. HCP has three structural domains, an N-terminal alpha-helical domain, and two similar domains comprising a...; Region: HCP; cd01914 272562010811 cubane metal cluster [ion binding]; other site 272562010812 hybrid metal cluster; other site 272562010813 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 272562010814 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 272562010815 active site 272562010816 phosphorylation site [posttranslational modification] 272562010817 intermolecular recognition site; other site 272562010818 dimerization interface [polypeptide binding]; other site 272562010819 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 272562010820 DNA binding residues [nucleotide binding] 272562010821 dimerization interface [polypeptide binding]; other site 272562010822 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: COG4585 272562010823 Dolichyl-phosphate-mannose-protein mannosyltransferase; Region: PMT_2; cl19158 272562010824 Histidine kinase; Region: HisKA_3; pfam07730 272562010825 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 272562010826 ATP binding site [chemical binding]; other site 272562010827 Mg2+ binding site [ion binding]; other site 272562010828 G-X-G motif; other site 272562010829 Predicted exporters of the RND superfamily [General function prediction only]; Region: COG1033 272562010830 MMPL family; Region: MMPL; cl14618 272562010831 MMPL family; Region: MMPL; cl14618 272562010832 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 272562010833 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 272562010834 Bacterial regulatory proteins, tetR family; Region: TetR_N; cl19382 272562010835 Carbohydrate binding domain; Region: CBM_4_9; pfam02018 272562010836 Alpha-L-arabinofuranosidase [Carbohydrate transport and metabolism]; Region: AbfA; COG3534 272562010837 Alpha-L-arabinofuranosidase C-terminus; Region: Alpha-L-AF_C; smart00813 272562010838 Domain of Unknown Function (DUF1080); Region: DUF1080; pfam06439 272562010839 Antirepressor regulating drug resistance, predicted signal transduction N-terminal membrane component [Transcription / Signal transduction mechanisms]; Region: MecR1; COG4219 272562010840 Transcriptional regulators [Transcription]; Region: MarR; COG1846 272562010841 Predicted transcriptional regulator [Transcription]; Region: COG3682 272562010842 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 272562010843 putative DNA binding site [nucleotide binding]; other site 272562010844 putative Zn2+ binding site [ion binding]; other site 272562010845 Predicted membrane protein [Function unknown]; Region: COG4129 272562010846 Fusaric acid resistance protein-like; Region: FUSC_2; pfam13515 272562010847 Bacterial SNF2 helicase associated; Region: SNF2_assoc; pfam08455 272562010848 Superfamily II DNA/RNA helicases, SNF2 family [Transcription / DNA replication, recombination, and repair]; Region: HepA; COG0553 272562010849 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 272562010850 ATP binding site [chemical binding]; other site 272562010851 putative Mg++ binding site [ion binding]; other site 272562010852 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 272562010853 nucleotide binding region [chemical binding]; other site 272562010854 ATP-binding site [chemical binding]; other site 272562010855 DNA polymerase III, alpha subunit (gram-positive type) [DNA replication, recombination, and repair]; Region: PolC; COG2176 272562010856 DNA polymerase III polC-type N-terminus I; Region: DNA_pol3_a_NI; pfam14480 272562010857 DNA polymerase III polC-type N-terminus II; Region: DNA_pol3_a_NII; pfam11490 272562010858 polC_OBF: A subfamily of OB folds corresponding to the N-terminal OB-fold nucleic acid binding domain of Bacillus subtilis type C replicative DNA polymerase III alpha subunit (polC). Replication in B. subtilis and Staphylococcus aureus requires two...; Region: polC_OBF; cd04484 272562010859 generic binding surface II; other site 272562010860 generic binding surface I; other site 272562010861 Polymerase and Histidinol Phosphatase domain of alpha-subunit of bacterial polymerase III at PolC gene; Region: PHP_PolIIIA_POLC; cd07435 272562010862 active site 272562010863 DEDDh 3'-5' exonuclease domain family; Region: DEDDh; cd06127 272562010864 active site 272562010865 catalytic site [active] 272562010866 substrate binding site [chemical binding]; other site 272562010867 putative PHP Thumb interface [polypeptide binding]; other site 272562010868 Bacterial DNA polymerase III alpha subunit; Region: DNA_pol3_alpha; pfam07733 272562010869 Helix-hairpin-helix motif; Region: HHH_6; pfam14579 272562010870 Predicted transcriptional regulators [Transcription]; Region: SoxR; COG0789 272562010871 Helix-Turn-Helix DNA binding domain of the BltR transcription regulator; Region: HTH_BltR; cd04782 272562010872 DNA binding residues [nucleotide binding] 272562010873 dimer interface [polypeptide binding]; other site 272562010874 Transcriptional regulator, effector-binding domain/component [Transcription / Signal transduction mechanisms]; Region: COG4978 272562010875 Na+-driven multidrug efflux pump [Defense mechanisms]; Region: NorM; COG0534 272562010876 Subfamily of the multidrug and toxic compound extrusion (MATE)-like proteins similar to Thermotoga marina NorM; Region: MATE_NorM_like; cd13137 272562010877 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 272562010878 Coenzyme A binding pocket [chemical binding]; other site 272562010879 Predicted epimerase, PhzC/PhzF homolog [General function prediction only]; Region: COG0384 272562010880 hypothetical protein; Provisional; Region: PRK10281 272562010881 DsbA family, FrnE subfamily; FrnE is a DsbA-like protein containing a CXXC motif. It is presumed to be a thiol oxidoreductase involved in polyketide biosynthesis, specifically in the production of the aromatic antibiotics frenolicin and nanaomycins; Region: DsbA_FrnE; cd03024 272562010882 catalytic residues [active] 272562010883 Members of the SGNH-hydrolase superfamily, a diverse family of lipases and esterases. The tertiary fold of the enzyme is substantially different from that of the alpha/beta hydrolase family and unique among all known hydrolases; its active site closely...; Region: SGNH_hydrolase_like_4; cd04501 272562010884 active site 272562010885 catalytic triad [active] 272562010886 oxyanion hole [active] 272562010887 TPR repeat; Region: TPR_11; pfam13414 272562010888 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 272562010889 binding surface 272562010890 TPR motif; other site 272562010891 TPR repeat; Region: TPR_11; pfam13414 272562010892 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 272562010893 binding surface 272562010894 TPR repeat; Region: TPR_11; pfam13414 272562010895 TPR motif; other site 272562010896 TPR repeat; Region: TPR_11; pfam13414 272562010897 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 272562010898 binding surface 272562010899 TPR motif; other site 272562010900 Domain of unknown function (DUF2935); Region: DUF2935; pfam11155 272562010901 Domain of unknown function (DUF2935); Region: DUF2935; pfam11155 272562010902 Na+/melibiose symporter and related transporters [Carbohydrate transport and metabolism]; Region: MelB; COG2211 272562010903 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 272562010904 putative substrate translocation pore; other site 272562010905 Beta-xylosidase [Carbohydrate transport and metabolism]; Region: XynB; COG3507 272562010906 Glycosyl hydrolase family 43, beta-D-xylosidase; Region: GH43_XYL_1; cd09000 272562010907 inhibitor binding site; inhibition site 272562010908 active site 272562010909 lysine transporter; Provisional; Region: PRK10836 272562010910 Transmembrane amino acid transporter protein; Region: Aa_trans; cl17468 272562010911 Dihydrouridine synthase-like (DUS-like) FMN-binding domain. Members of this family catalyze the reduction of the 5,6-double bond of a uridine residue on tRNA. Dihydrouridine modification of tRNA is widely observed in prokaryotes and eukaryotes, and also...; Region: DUS_like_FMN; cd02801 272562010912 Dihydrouridine synthase (Dus); Region: Dus; pfam01207 272562010913 FMN binding site [chemical binding]; other site 272562010914 active site 272562010915 catalytic residues [active] 272562010916 substrate binding site [chemical binding]; other site 272562010917 Uncharacterized conserved protein [Function unknown]; Region: COG3543 272562010918 Uncharacterized conserved protein [General function prediction only]; Region: BioY; COG1268 272562010919 BNR repeat-like domain; Region: BNR_2; pfam13088 272562010920 Predicted transcriptional regulators [Transcription]; Region: SoxR; COG0789 272562010921 MerR HTH family regulatory protein; Region: MerR_1; pfam13411 272562010922 DNA binding residues [nucleotide binding] 272562010923 Tubulin/FtsZ: Family includes tubulin alpha-, beta-, gamma-, delta-, and epsilon-tubulins as well as FtsZ, all of which are involved in polymer formation. Tubulin is the major component of microtubules, but also exists as a heterodimer and as a curved...; Region: Tubulin_FtsZ; cl10017 272562010924 Tubulin/FtsZ family, GTPase domain; Region: Tubulin; pfam00091 272562010925 nucleotide binding site [chemical binding]; other site 272562010926 V-type ATP synthase subunit I; Validated; Region: PRK05771 272562010927 MAEBL; Provisional; Region: PTZ00121 272562010928 3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05653 272562010929 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 272562010930 NAD(P) binding site [chemical binding]; other site 272562010931 active site 272562010932 Uncharacterized Fe-S center protein [General function prediction only]; Region: COG2768 272562010933 Nicotinamidase_ related amidohydrolases. Cysteine hydrolases of unknown function that share the catalytic triad with other amidohydrolases, like nicotinamidase, which converts nicotinamide to nicotinic acid and ammonia; Region: nicotinamidase_related; cd01014 272562010934 catalytic triad [active] 272562010935 conserved cis-peptide bond; other site 272562010936 Transcriptional regulator [Transcription]; Region: LysR; COG0583 272562010937 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 272562010938 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cd05466 272562010939 dimerization interface [polypeptide binding]; other site 272562010940 Escherichia coli PhnB and similar proteins; the E. coli phnB gene is found next to an operon involved in the cleavage of carbon-phosphorus bonds in unactivated alkylphosphonates; Region: PhnB_like; cd06588 272562010941 dimer interface [polypeptide binding]; other site 272562010942 Escherichia coli PhnB and similar proteins; the E. coli phnB gene is found next to an operon involved in the cleavage of carbon-phosphorus bonds in unactivated alkylphosphonates; Region: PhnB_like; cd06588 272562010943 dimer interface [polypeptide binding]; other site 272562010944 Nuclease subunit of the excinuclease complex [DNA replication, recombination, and repair]; Region: UvrC; COG0322 272562010945 Catalytic GIY-YIG domain of nucleotide excision repair endonucleases UvrC, Cho, and similar proteins; Region: GIY-YIG_UvrC_Cho; cd10434 272562010946 GIY-YIG motif/motif A; other site 272562010947 active site 272562010948 catalytic site [active] 272562010949 putative DNA binding site [nucleotide binding]; other site 272562010950 metal binding site [ion binding]; metal-binding site 272562010951 UvrB/uvrC motif; Region: UVR; pfam02151 272562010952 Endoglucanase [Carbohydrate transport and metabolism]; Region: BglC; COG2730 272562010953 Cellulase (glycosyl hydrolase family 5); Region: Cellulase; pfam00150 272562010954 guanosine 5'-monophosphate oxidoreductase; Provisional; Region: PRK05458 272562010955 IMPDH: The catalytic domain of the inosine monophosphate dehydrogenase. IMPDH catalyzes the NAD-dependent oxidation of inosine 5'-monophosphate (IMP) to xanthosine 5' monophosphate (XMP). It is a rate-limiting step in the de novo synthesis of...; Region: IMPDH; cd00381 272562010956 active site 272562010957 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 272562010958 non-specific DNA binding site [nucleotide binding]; other site 272562010959 salt bridge; other site 272562010960 sequence-specific DNA binding site [nucleotide binding]; other site 272562010961 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 272562010962 Major Facilitator Superfamily; Region: MFS_1; pfam07690 272562010963 putative substrate translocation pore; other site 272562010964 Predicted transcriptional regulators [Transcription]; Region: SoxR; COG0789 272562010965 Helix-Turn-Helix DNA binding domain of the transcription regulators TipAL, Mta, and SkgA; Region: HTH_TipAL-Mta; cd01106 272562010966 DNA binding residues [nucleotide binding] 272562010967 dimer interface [polypeptide binding]; other site 272562010968 TipAS antibiotic-recognition domain; Region: TipAS; pfam07739 272562010969 ligand binding domain of Tar- and Tsr-related chemoreceptors; Region: Tar_Tsr_LBD; cl00144 272562010970 Methyl-accepting chemotaxis protein [Cell motility and secretion / Signal transduction mechanisms]; Region: Tar; COG0840 272562010971 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cl19050 272562010972 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cl19050 272562010973 dimer interface [polypeptide binding]; other site 272562010974 putative CheW interface [polypeptide binding]; other site 272562010975 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 272562010976 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 272562010977 Arabinose efflux permease [Carbohydrate transport and metabolism]; Region: AraJ; COG2814 272562010978 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 272562010979 putative substrate translocation pore; other site 272562010980 The HCP family of iron-sulfur proteins includes hybrid cluster protein (HCP), acetyl-CoA synthase (ACS), and carbon monoxide dehydrogenase (CODH), all of which contain [Fe4-S4] metal clusters at their active sites. These proteins have a conserved...; Region: HCP_like; cl19102 272562010981 4Fe-4S dicluster domain; Region: Fer4_7; pfam12838 272562010982 Nitroreductase family. Members of this family utilize FMN as a cofactor. This family is involved in the reduction of flavin or nitroaromatic compounds by using NAD(P)H as electron donor in a obligatory two-electron transfer. Nitrogenase is homodimer; Region: NADH_nitroreductase; cd02143 272562010983 putative FMN binding site [chemical binding]; other site 272562010984 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 272562010985 Dehydrogenases with different specificities (related to short-chain alcohol dehydrogenases) [Secondary metabolites biosynthesis, transport, and catabolism / General function prediction only]; Region: FabG; COG1028 272562010986 NAD(P) binding site [chemical binding]; other site 272562010987 active site 272562010988 Transcriptional regulators [Transcription]; Region: MarR; COG1846 272562010989 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cl17220 272562010990 putative Zn2+ binding site [ion binding]; other site 272562010991 putative DNA binding site [nucleotide binding]; other site 272562010992 Multimeric flavodoxin WrbA [General function prediction only]; Region: WrbA; COG0655 272562010993 Predicted transcriptional regulators [Transcription]; Region: COG1733 272562010994 putative DNA binding site [nucleotide binding]; other site 272562010995 putative Zn2+ binding site [ion binding]; other site 272562010996 Predicted transcriptional regulators [Transcription]; Region: COG1733 272562010997 DNA gyrase inhibitor [DNA replication, recombination, and repair]; Region: COG3449 272562010998 Uncharacterized stress protein (general stress protein 26) [General function prediction only]; Region: COG3871 272562010999 Pyridoxamine 5'-phosphate oxidase; Region: Pyridox_oxidase; pfam01243 272562011000 DNA repair photolyase [DNA replication, recombination, and repair]; Region: SplB; COG1533 272562011001 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 272562011002 FeS/SAM binding site; other site 272562011003 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3708 272562011004 Predicted transcriptional regulator [Transcription]; Region: COG2378 272562011005 HTH domain; Region: HTH_11; pfam08279 272562011006 WYL domain; Region: WYL; pfam13280 272562011007 Multimeric flavodoxin WrbA [General function prediction only]; Region: WrbA; COG0655 272562011008 Predicted transcriptional regulators [Transcription]; Region: COG1733 272562011009 Fructoselysine kinase-like. Fructoselysine is a fructoseamine formed by glycation, a non-enzymatic reaction of glucose with a primary amine followed by an Amadori rearrangement, resulting in a protein that is modified at the amino terminus and at the...; Region: Fructoselysine_kinase_like; cd01940 272562011010 substrate binding site [chemical binding]; other site 272562011011 ATP binding site [chemical binding]; other site 272562011012 Sugar phosphate isomerases/epimerases [Carbohydrate transport and metabolism]; Region: IolE; COG1082 272562011013 Xylose isomerase-like TIM barrel; Region: AP_endonuc_2; pfam01261 272562011014 Anaerobic C4-dicarboxylate transporter [General function prediction only]; Region: DcuB; COG2704 272562011015 Predicted phosphosugar isomerases [Cell envelope biogenesis, outer membrane]; Region: AgaS; COG2222 272562011016 A subgroup of the SIS domain. SIS (Sugar ISomerase) domains are found in many phosphosugar isomerases and phosphosugar binding proteins. SIS domains are also found in proteins that regulate the expression of genes involved in synthesis of phosphosugars; Region: SIS_1; cd05710 272562011017 putative active site [active] 272562011018 SIS (Sugar ISomerase) domain repeat 2 found in Glucosamine 6-phosphate synthase (GlmS) and Glucosamine-6-phosphate deaminase (GlmD). The SIS domain is found in many phosphosugar isomerases and phosphosugar binding proteins. GlmS contains a N-terminal...; Region: SIS_GlmS_GlmD_2; cd05009 272562011019 dimer interface [polypeptide binding]; other site 272562011020 active site 272562011021 Transcriptional regulators [Transcription]; Region: PhnF; COG2188 272562011022 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 272562011023 DNA-binding site [nucleotide binding]; DNA binding site 272562011024 UTRA domain; Region: UTRA; pfam07702 272562011025 aldehyde reductase, extended (e) SDRs; Region: AR_SDR_e; cd05227 272562011026 Nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: WcaG; COG0451 272562011027 NADP binding site [chemical binding]; other site 272562011028 putative substrate binding site [chemical binding]; other site 272562011029 active site 272562011030 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 272562011031 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 272562011032 Multimeric flavodoxin WrbA [General function prediction only]; Region: WrbA; COG0655 272562011033 Arabinose efflux permease [Carbohydrate transport and metabolism]; Region: AraJ; COG2814 272562011034 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 272562011035 putative substrate translocation pore; other site 272562011036 Predicted transcriptional regulators [Transcription]; Region: SoxR; COG0789 272562011037 Helix-Turn-Helix DNA binding domain of the MerR-like transcription regulators YyaN and YraB; Region: HTH_YyaN; cd01109 272562011038 DNA binding residues [nucleotide binding] 272562011039 putative dimer interface [polypeptide binding]; other site 272562011040 Predicted aminopeptidases [General function prediction only]; Region: Iap; COG2234 272562011041 Zinc peptidases M18, M20, M28, and M42; Region: Zinc_peptidase_like; cl14876 272562011042 metal binding site [ion binding]; metal-binding site 272562011043 Predicted transcriptional regulators [Transcription]; Region: SoxR; COG0789 272562011044 First Helix-Turn-Helix DNA binding domain of the regulatory protein TioE; Region: HTH_TioE_rpt1; cd04772 272562011045 DNA binding residues [nucleotide binding] 272562011046 putative dimer interface [polypeptide binding]; other site 272562011047 Predicted transcriptional regulators [Transcription]; Region: SoxR; COG0789 272562011048 Helix-Turn-Helix DNA binding domain of transcription regulators from the MerR superfamily; Region: HTH_MerR-SF; cd04761 272562011049 DNA binding residues [nucleotide binding] 272562011050 Cache domain; Region: Cache_1; pfam02743 272562011051 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 272562011052 dimerization interface [polypeptide binding]; other site 272562011053 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cl19050 272562011054 Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer); Region: MA; smart00283 272562011055 dimer interface [polypeptide binding]; other site 272562011056 putative CheW interface [polypeptide binding]; other site 272562011057 Four helix bundle sensory module for signal transduction; Region: 4HB_MCP_1; pfam12729 272562011058 Methyl-accepting chemotaxis protein [Cell motility and secretion / Signal transduction mechanisms]; Region: Tar; COG0840 272562011059 HAMP domain; Region: HAMP; pfam00672 272562011060 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cl19050 272562011061 dimer interface [polypeptide binding]; other site 272562011062 putative CheW interface [polypeptide binding]; other site 272562011063 AraC-like ligand binding domain; Region: AraC_binding; pfam02311 272562011064 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 272562011065 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 272562011066 Retron-type reverse transcriptase [DNA replication, recombination, and repair]; Region: COG3344 272562011067 RT_G2_intron: Reverse transcriptases (RTs) with group II intron origin. RT transcribes DNA using RNA as template. Proteins in this subfamily are found in bacterial and mitochondrial group II introns. Their most probable ancestor was a retrotransposable...; Region: RT_G2_intron; cd01651 272562011068 putative active site [active] 272562011069 putative NTP binding site [chemical binding]; other site 272562011070 putative nucleic acid binding site [nucleotide binding]; other site 272562011071 Group II intron, maturase-specific domain; Region: GIIM; pfam08388 272562011072 Putative lysophospholipase; Region: Hydrolase_4; cl19140 272562011073 Alpha/beta hydrolase family; Region: Abhydrolase_5; pfam12695 272562011074 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 272562011075 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 272562011076 dimerization interface [polypeptide binding]; other site 272562011077 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 272562011078 dimer interface [polypeptide binding]; other site 272562011079 phosphorylation site [posttranslational modification] 272562011080 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 272562011081 ATP binding site [chemical binding]; other site 272562011082 Mg2+ binding site [ion binding]; other site 272562011083 G-X-G motif; other site 272562011084 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 272562011085 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 272562011086 active site 272562011087 phosphorylation site [posttranslational modification] 272562011088 intermolecular recognition site; other site 272562011089 dimerization interface [polypeptide binding]; other site 272562011090 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 272562011091 DNA binding site [nucleotide binding] 272562011092 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 272562011093 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 272562011094 ABC-type transport system involved in multi-copper enzyme maturation, permease component [General function prediction only]; Region: NosY; COG1277 272562011095 ABC-type multidrug transport system, ATPase component [Defense mechanisms]; Region: CcmA; COG1131 272562011096 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 272562011097 Walker A/P-loop; other site 272562011098 ATP binding site [chemical binding]; other site 272562011099 Q-loop/lid; other site 272562011100 ABC transporter signature motif; other site 272562011101 Walker B; other site 272562011102 D-loop; other site 272562011103 H-loop/switch region; other site 272562011104 NAD+--asparagine ADP-ribosyltransferase [Signal transduction mechanisms]; Region: COG5585 272562011105 Predicted transcriptional regulator [Transcription]; Region: COG1959 272562011106 Rrf2 family protein; Region: rrf2_super; TIGR00738 272562011107 Pyridoxamine 5'-phosphate oxidase; Region: Pyridox_oxidase; pfam01243 272562011108 The HCP family of iron-sulfur proteins includes hybrid cluster protein (HCP), acetyl-CoA synthase (ACS), and carbon monoxide dehydrogenase (CODH), all of which contain [Fe4-S4] metal clusters at their active sites. These proteins have a conserved...; Region: HCP_like; cl19102 272562011109 4Fe-4S dicluster domain; Region: Fer4_7; pfam12838 272562011110 Protein of unknown function (DUF4238); Region: DUF4238; pfam14022 272562011111 accessory Sec system protein Asp2; Region: acc_sec_asp2; TIGR03712 272562011112 Transposase IS200 like; Region: Y1_Tnp; pfam01797 272562011113 Adenine-specific DNA methylase [DNA replication, recombination, and repair]; Region: COG0827 272562011114 Methyltransferase domain; Region: Methyltransf_26; pfam13659 272562011115 Type I restriction enzyme R protein N terminus (HSDR_N); Region: HSDR_N; pfam04313 272562011116 Type II restriction enzyme, methylase subunits [Defense mechanisms]; Region: COG1002 272562011117 Eco57I restriction-modification methylase; Region: Eco57I; pfam07669 272562011118 rRNA large subunit methyltransferase; Provisional; Region: PRK00103 272562011119 hypothetical protein; Provisional; Region: PRK05590 272562011120 SEC-C motif; Region: SEC-C; pfam02810 272562011121 Metal-dependent hydrolases of the beta-lactamase superfamily I [General function prediction only]; Region: PhnP; COG1235 272562011122 EPSP synthase (3-phosphoshikimate 1-carboxyvinyltransferase); Region: EPSP_synthase; pfam00275 272562011123 UDP-N-acetylglucosamine enolpyruvyl transferase catalyzes enolpyruvyl transfer as part of the first step in the biosynthesis of peptidoglycan, a component of the bacterial cell wall. The reaction is phosphoenolpyruvate + UDP-N-acetyl-D-glucosamine =...; Region: UdpNAET; cd01555 272562011124 hinge; other site 272562011125 active site 272562011126 Domain of Unknown Function (DUF1540); Region: DUF1540; pfam07561 272562011127 dUTPase; Region: dUTPase_2; pfam08761 272562011128 Nucleoside Triphosphate Pyrophosphohydrolase (EC 3.6.1.8) MazG-like domain found in dimeric 2-Deoxyuridine 5'-triphosphate nucleotidohydrolase and similar proteins; Region: NTP-PPase_dUTPase; cd11527 272562011129 active site 272562011130 homodimer interface [polypeptide binding]; other site 272562011131 metal binding site [ion binding]; metal-binding site 272562011132 fumarate reductase flavoprotein subunit; Validated; Region: PRK06481 272562011133 5TMR of 5TMR-LYT; Region: 5TM-5TMR_LYT; pfam07694 272562011134 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 272562011135 metal binding site [ion binding]; metal-binding site 272562011136 active site 272562011137 I-site; other site 272562011138 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cl19050 272562011139 dimer interface [polypeptide binding]; other site 272562011140 putative CheW interface [polypeptide binding]; other site 272562011141 Highly conserved protein containing a thioredoxin domain [Posttranslational modification, protein turnover, chaperones]; Region: COG1331 272562011142 TRX domain, SSP411 protein family; members of this family are highly conserved proteins present in eukaryotes, bacteria and archaea, about 600-800 amino acids in length, which contain a TRX domain with a redox active CXXC motif. The human/rat protein; Region: SSP411; cd02955 272562011143 catalytic residues [active] 272562011144 Glycine/sarcosine/betaine reductase component B subunits; Region: Gly_reductase; pfam09338 272562011145 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3238 272562011146 putative regulatory protein, FmdB family; Region: CxxC_CxxC_SSSS; TIGR02605 272562011147 Peptidase domain in the S8 and S53 families; Region: Peptidases_S8_S53; cl10459 272562011148 Subtilase family; Region: Peptidase_S8; pfam00082 272562011149 active site 272562011150 catalytic residues [active] 272562011151 ABC-type Na+ efflux pump, permease component [Energy production and conversion / Inorganic ion transport and metabolism]; Region: NatB; COG1668 272562011152 ABC-2 family transporter protein; Region: ABC2_membrane_2; pfam12679 272562011153 ABC-type Na+ transport system, ATPase component [Energy production and conversion / Inorganic ion transport and metabolism]; Region: NatA; COG4555 272562011154 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 272562011155 Walker A/P-loop; other site 272562011156 ATP binding site [chemical binding]; other site 272562011157 Q-loop/lid; other site 272562011158 ABC transporter signature motif; other site 272562011159 Walker B; other site 272562011160 D-loop; other site 272562011161 H-loop/switch region; other site 272562011162 A subgroup of L-lactate dehydrogenases; Region: LDH_3; cd05290 272562011163 L-lactate dehydrogenase; Region: L-LDH-NAD; TIGR01771 272562011164 NAD binding site [chemical binding]; other site 272562011165 dimer interface [polypeptide binding]; other site 272562011166 tetramer (dimer of dimers) interface [polypeptide binding]; other site 272562011167 substrate binding site [chemical binding]; other site 272562011168 Transcriptional regulators [Transcription]; Region: PurR; COG1609 272562011169 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 272562011170 DNA binding site [nucleotide binding] 272562011171 domain linker motif; other site 272562011172 Ligand-binding domain of DNA transcription repressor for the hexuronate utilization operon from Bacillus species and its close homologs from other bacteria, all of which are a member of the LacI-GalR family of bacterial transcription regulators; Region: PBP1_hexuronate_repressor_like; cd06272 272562011173 putative dimerization interface [polypeptide binding]; other site 272562011174 putative ligand binding site [chemical binding]; other site 272562011175 Uncharacterized protein containing a NRPS condensation (elongation) domain [General function prediction only]; Region: COG4908 272562011176 Condensation domain; Region: Condensation; cl19241 272562011177 NAD(P)H:flavin oxidoreductase-like family 2. A subfamily of the nitroreductase family containing uncharacterized proteins that are similar to nitroreductase. Nitroreductase catalyzes the reduction of nitroaromatic compounds such as nitrotoluenes; Region: NADPH_oxidoreductase_2; cd02151 272562011178 putative FMN binding site [chemical binding]; other site 272562011179 Right handed beta helix region; Region: Beta_helix; pfam13229 272562011180 Right handed beta helix region; Region: Beta_helix; pfam13229 272562011181 HlyD family secretion protein; Region: HlyD_3; pfam13437 272562011182 ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136 272562011183 ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255 272562011184 Walker A/P-loop; other site 272562011185 ATP binding site [chemical binding]; other site 272562011186 Q-loop/lid; other site 272562011187 ABC transporter signature motif; other site 272562011188 Walker B; other site 272562011189 D-loop; other site 272562011190 H-loop/switch region; other site 272562011191 ABC-type transport system, involved in lipoprotein release, permease component [Cell envelope biogenesis, outer membrane]; Region: LolE; COG4591 272562011192 MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704 272562011193 FtsX-like permease family; Region: FtsX; pfam02687 272562011194 ABC-type antimicrobial peptide transport system, permease component [Defense mechanisms]; Region: SalY; COG0577 272562011195 FtsX-like permease family; Region: FtsX; pfam02687 272562011196 tRNA nucleotidyltransferase/poly(A) polymerase [Translation, ribosomal structure and biogenesis]; Region: PcnB; COG0617 272562011197 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 272562011198 Zn2+ binding site [ion binding]; other site 272562011199 Mg2+ binding site [ion binding]; other site 272562011200 DNA-binding domain of DNA mismatch repair MUTS family; Region: MUTSd; smart00533 272562011201 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 272562011202 Walker A/P-loop; other site 272562011203 ATP binding site [chemical binding]; other site 272562011204 Q-loop/lid; other site 272562011205 ABC transporter signature motif; other site 272562011206 Walker B; other site 272562011207 D-loop; other site 272562011208 H-loop/switch region; other site 272562011209 aspartyl-tRNA synthetase; Provisional; Region: aspC; PRK05159 272562011210 Asp_Lys_Asn_RS_N: N-terminal, anticodon recognition domain of class 2b aminoacyl-tRNA synthetases (aaRSs). This domain is a beta-barrel domain (OB fold) involved in binding the tRNA anticodon stem-loop. Class 2b aaRSs include the homodimeric aspartyl-; Region: Asp_Lys_Asn_RS_N; cd04100 272562011211 Dimer interface [polypeptide binding]; other site 272562011212 anticodon binding site; other site 272562011213 Asx tRNA synthetase (AspRS/AsnRS) class II core domain. Assignment to class II aminoacyl-tRNA synthetases (aaRS) based upon its structure and the presence of three characteristic sequence motifs in the core domain. This family includes AsnRS as well as...; Region: AsxRS_core; cd00776 272562011214 homodimer interface [polypeptide binding]; other site 272562011215 motif 1; other site 272562011216 motif 2; other site 272562011217 active site 272562011218 motif 3; other site 272562011219 Bacterial surface proteins containing Ig-like domains [Cell motility and secretion]; Region: COG5492 272562011220 Bacterial Ig-like domain (group 2); Region: Big_2; cl02708 272562011221 DNA topoisomerase III; Provisional; Region: PRK07726 272562011222 TOPRIM_TopoIA_TopoIII: The topoisomerase-primase (TORPIM) domain found in members of the type IA family of DNA topoisomerases (Topo IA) similar to topoisomerase III. Type IA DNA topoisomerases remove (relax) negative supercoils in the DNA by: cleaving...; Region: TOPRIM_TopoIA_TopoIII; cd03362 272562011223 active site 272562011224 putative interdomain interaction site [polypeptide binding]; other site 272562011225 putative metal-binding site [ion binding]; other site 272562011226 putative nucleotide binding site [chemical binding]; other site 272562011227 DNA Topoisomerase, subtype IA; DNA-binding, ATP-binding and catalytic domain of bacterial DNA topoisomerases I and III, and eukaryotic DNA topoisomerase III and eubacterial and archael reverse gyrases. Topoisomerases clevage single or double stranded DNA...; Region: TOP1Ac; cd00186 272562011228 domain I; other site 272562011229 DNA binding groove [nucleotide binding] 272562011230 phosphate binding site [ion binding]; other site 272562011231 domain II; other site 272562011232 domain III; other site 272562011233 nucleotide binding site [chemical binding]; other site 272562011234 catalytic site [active] 272562011235 domain IV; other site 272562011236 acetyl-CoA carboxylase carboxyltransferase subunit alpha; Validated; Region: PRK05724 272562011237 acetyl-CoA carboxylase subunit beta; Validated; Region: PRK05654 272562011238 biotin carboxylase; Validated; Region: PRK05586 272562011239 Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289 272562011240 ATP-grasp domain; Region: ATP-grasp_4; cl17255 272562011241 Biotin carboxylase C-terminal domain; Region: Biotin_carb_C; smart00878 272562011242 FabZ is a 17kD beta-hydroxyacyl-acyl carrier protein (ACP) dehydratase that primarily catalyzes the dehydration of beta-hydroxyacyl-ACP to trans-2-acyl-ACP, the third step in the elongation phase of the bacterial/ plastid, type II, fatty-acid...; Region: FabZ; cd01288 272562011243 acetyl-CoA carboxylase biotin carboxyl carrier protein subunit; Validated; Region: PRK06302 272562011244 The biotinyl-domain or biotin carboxyl carrier protein (BCCP) domain is present in all biotin-dependent enzymes, such as acetyl-CoA carboxylase, pyruvate carboxylase, propionyl-CoA carboxylase, methylcrotonyl-CoA carboxylase, geranyl-CoA carboxylase; Region: biotinyl_domain; cd06850 272562011245 carboxyltransferase (CT) interaction site; other site 272562011246 biotinylation site [posttranslational modification]; other site 272562011247 beta-ketoacyl-acyl-carrier-protein synthase II; Region: fabF; TIGR03150 272562011248 Beta-ketoacyl-acyl carrier protein (ACP) synthase (KAS), type I and II. KASs are responsible for the elongation steps in fatty acid biosynthesis. KASIII catalyses the initial condensation and KAS I and II catalyze further elongation steps by Claisen...; Region: KAS_I_II; cd00834 272562011249 dimer interface [polypeptide binding]; other site 272562011250 active site 272562011251 3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05557 272562011252 beta-Keto acyl carrier protein reductase (BKR), involved in Type II FAS, classical (c) SDRs; Region: BKR_SDR_c; cd05333 272562011253 NAD(P) binding site [chemical binding]; other site 272562011254 homotetramer interface [polypeptide binding]; other site 272562011255 homodimer interface [polypeptide binding]; other site 272562011256 active site 272562011257 (acyl-carrier-protein) S-malonyltransferase [Lipid metabolism]; Region: FabD; COG0331 272562011258 Polyketide synthase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG3321 272562011259 putative enoyl-[acyl-carrier-protein] reductase II; Region: enACPred_II; TIGR03151 272562011260 2-Nitropropane dioxygenase (NPD), one of the nitroalkane oxidizing enzyme families, catalyzes oxidative denitrification of nitroalkanes to their corresponding carbonyl compounds and nitrites. NDP is a member of the NAD(P)H-dependent flavin oxidoreductase...; Region: NPD_like; cd04730 272562011261 FMN binding site [chemical binding]; other site 272562011262 substrate binding site [chemical binding]; other site 272562011263 putative catalytic residue [active] 272562011264 acyl carrier protein; Provisional; Region: acpP; PRK00982 272562011265 3-oxoacyl-(acyl carrier protein) synthase III; Reviewed; Region: PRK09352 272562011266 Ketoacyl-acyl carrier protein synthase III (KASIII) initiates the elongation in type II fatty acid synthase systems. It is found in bacteria and plants. Elongation of fatty acids in the type II systems occurs by Claisen condensation of malonyl-acyl...; Region: KAS_III; cd00830 272562011267 dimer interface [polypeptide binding]; other site 272562011268 active site 272562011269 CoA binding pocket [chemical binding]; other site 272562011270 Transcriptional regulators [Transcription]; Region: MarR; COG1846 272562011271 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cl17220 272562011272 putative Zn2+ binding site [ion binding]; other site 272562011273 putative DNA binding site [nucleotide binding]; other site 272562011274 Dioxygenases related to 2-nitropropane dioxygenase [General function prediction only]; Region: COG2070 272562011275 2-Nitropropane dioxygenase (NPD), one of the nitroalkane oxidizing enzyme families, catalyzes oxidative denitrification of nitroalkanes to their corresponding carbonyl compounds and nitrites. NDP is a member of the NAD(P)H-dependent flavin oxidoreductase...; Region: NPD_like; cd04730 272562011276 FMN binding site [chemical binding]; other site 272562011277 substrate binding site [chemical binding]; other site 272562011278 putative catalytic residue [active] 272562011279 Haloacid dehalogenase-like hydrolase; Region: HAD_2; pfam13419 272562011280 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 272562011281 motif II; other site 272562011282 MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704 272562011283 ABC-type transport system, involved in lipoprotein release, permease component [Cell envelope biogenesis, outer membrane]; Region: LolE; COG4591 272562011284 FtsX-like permease family; Region: FtsX; pfam02687 272562011285 MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704 272562011286 ABC-type antimicrobial peptide transport system, permease component [Defense mechanisms]; Region: SalY; COG0577 272562011287 FtsX-like permease family; Region: FtsX; pfam02687 272562011288 ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136 272562011289 ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255 272562011290 Walker A/P-loop; other site 272562011291 ATP binding site [chemical binding]; other site 272562011292 Q-loop/lid; other site 272562011293 ABC transporter signature motif; other site 272562011294 Walker B; other site 272562011295 D-loop; other site 272562011296 H-loop/switch region; other site 272562011297 competence damage-inducible protein A; Provisional; Region: PRK00549 272562011298 Competence-damaged protein. CinA is the first gene in the competence- inducible (cin) operon and is thought to be specifically required at some stage in the process of transformation. This domain is closely related to a domain, found in a variety of...; Region: cinA; cd00885 272562011299 putative MPT binding site; other site 272562011300 Competence-damaged protein; Region: CinA; pfam02464 272562011301 Putative primosome component and related proteins [DNA replication, recombination, and repair]; Region: DnaD; COG3935 272562011302 Replication initiation and membrane attachment; Region: DnaB_2; pfam07261 272562011303 DnaD and phage-associated domain; Region: DnaD_dom; TIGR01446 272562011304 DNA replication protein DnaC; Validated; Region: PRK06835 272562011305 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 272562011306 Walker A motif; other site 272562011307 ATP binding site [chemical binding]; other site 272562011308 Walker B motif; other site 272562011309 Predicted membrane protein [Function unknown]; Region: COG1511 272562011310 YhgE/Pip N-terminal domain; Region: pip_yhgE_Nterm; TIGR03061 272562011311 YhgE/Pip C-terminal domain; Region: pip_yhgE_Cterm; TIGR03062 272562011312 HI0933-like protein; Region: HI0933_like; pfam03486 272562011313 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 272562011314 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl19134 272562011315 Acyl-ACP thioesterase [Lipid metabolism]; Region: FatA; COG3884 272562011316 4-hydroxybenzoyl-CoA thioesterase (4HBT). Catalyzes the final step in the 4-chlorobenzoate degradation pathway in which 4-chlorobenzoate is converted to 4-hydroxybenzoate in certain soil-dwelling bacteria. 4HBT forms a homotetramer with four active sites; Region: 4HBT; cd00586 272562011317 active site 272562011318 4-hydroxybenzoyl-CoA thioesterase (4HBT). Catalyzes the final step in the 4-chlorobenzoate degradation pathway in which 4-chlorobenzoate is converted to 4-hydroxybenzoate in certain soil-dwelling bacteria. 4HBT forms a homotetramer with four active sites; Region: 4HBT; cd00586 272562011319 active site 272562011320 hybrid cluster protein-associated redox disulfide domain; Region: prismane_assoc; TIGR03980 272562011321 Adenylosuccinate synthetase (AdSS) catalyzes the first step in the de novo biosynthesis of AMP. IMP and L-aspartate are conjugated in a two-step reaction accompanied by the hydrolysis of GTP to GDP in the presence of Mg2+. In the first step, the...; Region: AdSS; cd03108 272562011322 GDP-binding site [chemical binding]; other site 272562011323 ACT binding site; other site 272562011324 IMP binding site; other site 272562011325 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 272562011326 This family is most closely related to the GT1 family of glycosyltransferases. UDP-glucose-diacylglycerol glucosyltransferase (UGDG; also known as 1,2-diacylglycerol 3-glucosyltransferase) catalyzes the transfer of glucose from UDP-glucose to 1; Region: GT1_UGDG_like; cd03817 272562011327 putative ADP-binding pocket [chemical binding]; other site 272562011328 Uncharacterized FAD-dependent dehydrogenases [General function prediction only]; Region: COG2509 272562011329 CDP-alcohol phosphatidyltransferase; Region: CDP-OH_P_transf; cl00453 272562011330 Rubredoxin [Energy production and conversion]; Region: COG1773 272562011331 Rubredoxin, Small Modular nonheme iron binding domain containing a [Fe(SCys)4] center, present in rubrerythrin and nigerythrin and detected either N- or C-terminal to such proteins as flavin reductase, NAD(P)H-nitrite reductase, and...; Region: rubredoxin_SM; cd00729 272562011332 iron binding site [ion binding]; other site 272562011333 Rubrerythrin [Energy production and conversion]; Region: COG1592 272562011334 rubrerythrin-like, diiron-binding domain; Region: Rubrerythrin_like; cd01046 272562011335 diiron binding motif [ion binding]; other site 272562011336 Rubredoxin [Energy production and conversion]; Region: COG1773 272562011337 Rubredoxin, Small Modular nonheme iron binding domain containing a [Fe(SCys)4] center, present in rubrerythrin and nigerythrin and detected either N- or C-terminal to such proteins as flavin reductase, NAD(P)H-nitrite reductase, and...; Region: rubredoxin_SM; cd00729 272562011338 iron binding site [ion binding]; other site 272562011339 Rubrerythrin [Energy production and conversion]; Region: COG1592 272562011340 rubrerythrin-like, diiron-binding domain; Region: Rubrerythrin_like; cd01046 272562011341 diiron binding motif [ion binding]; other site 272562011342 Dihydrodipicolinate synthase (DHDPS); Region: DHDPS; cd00950 272562011343 dimer interface [polypeptide binding]; other site 272562011344 active site 272562011345 catalytic residue [active] 272562011346 ADP-ribose pyrophosphatase (ADPRase) catalyzes the hydrolysis of ADP-ribose and a variety of additional ADP-sugar conjugates to AMP and ribose-5-phosphate. Like other members of the Nudix hydrolase superfamily, it requires a divalent cation, such as Mg2+; Region: ADPRase_NUDT5; cd03424 272562011347 dimer interface [polypeptide binding]; other site 272562011348 ADP-ribose binding site [chemical binding]; other site 272562011349 active site 272562011350 nudix motif; other site 272562011351 metal binding site [ion binding]; metal-binding site 272562011352 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 272562011353 Zn2+ binding site [ion binding]; other site 272562011354 Mg2+ binding site [ion binding]; other site 272562011355 Transcriptional regulators [Transcription]; Region: FadR; COG2186 272562011356 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 272562011357 DNA-binding site [nucleotide binding]; DNA binding site 272562011358 This entry represents the C-terminal ligand binding domain of many members of the GntR family; Region: FCD; smart00895 272562011359 Dihydroxyacid dehydratase/phosphogluconate dehydratase [Amino acid transport and metabolism / Carbohydrate transport and metabolism]; Region: IlvD; COG0129 272562011360 GntP family permease; Region: GntP_permease; pfam02447 272562011361 fructuronate transporter; Provisional; Region: PRK10034; cl15264 272562011362 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 272562011363 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 272562011364 Ketopantoate reductase [Coenzyme metabolism]; Region: ApbA; COG1893 272562011365 Ketopantoate reductase PanE/ApbA; Region: ApbA; pfam02558 272562011366 ABC-type multidrug transport system, ATPase component [Defense mechanisms]; Region: CcmA; COG1131 272562011367 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 272562011368 Walker A/P-loop; other site 272562011369 ATP binding site [chemical binding]; other site 272562011370 Q-loop/lid; other site 272562011371 ABC transporter signature motif; other site 272562011372 Walker B; other site 272562011373 D-loop; other site 272562011374 H-loop/switch region; other site 272562011375 ABC-2 type transporter; Region: ABC2_membrane; pfam01061 272562011376 ABC-2 family transporter protein; Region: ABC2_membrane_3; pfam12698 272562011377 ABC-2 type transporter; Region: ABC2_membrane; cl17235 272562011378 ABC-type multidrug transport system, permease component [Defense mechanisms]; Region: COG0842 272562011379 ATP-dependent transcriptional regulator [Transcription]; Region: MalT; COG2909 272562011380 AAA ATPase domain; Region: AAA_16; pfam13191 272562011381 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 272562011382 DNA binding residues [nucleotide binding] 272562011383 dimerization interface [polypeptide binding]; other site 272562011384 MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704 272562011385 FtsX-like permease family; Region: FtsX; pfam02687 272562011386 MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704 272562011387 ABC-type antimicrobial peptide transport system, permease component [Defense mechanisms]; Region: SalY; COG0577 272562011388 FtsX-like permease family; Region: FtsX; pfam02687 272562011389 ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136 272562011390 ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255 272562011391 Walker A/P-loop; other site 272562011392 ATP binding site [chemical binding]; other site 272562011393 Q-loop/lid; other site 272562011394 ABC transporter signature motif; other site 272562011395 Walker B; other site 272562011396 D-loop; other site 272562011397 H-loop/switch region; other site 272562011398 ABC-type polar amino acid transport system, ATPase component [Amino acid transport and metabolism]; Region: GlnQ; COG1126 272562011399 ATP-binding cassette domain of the histidine and glutamine transporters; Region: ABC_HisP_GlnQ; cd03262 272562011400 Walker A/P-loop; other site 272562011401 ATP binding site [chemical binding]; other site 272562011402 Q-loop/lid; other site 272562011403 ABC transporter signature motif; other site 272562011404 Walker B; other site 272562011405 D-loop; other site 272562011406 H-loop/switch region; other site 272562011407 ABC-type amino acid transport system, permease component [Amino acid transport and metabolism]; Region: HisM; COG0765 272562011408 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 272562011409 dimer interface [polypeptide binding]; other site 272562011410 conserved gate region; other site 272562011411 putative PBP binding loops; other site 272562011412 ABC-ATPase subunit interface; other site 272562011413 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 272562011414 Bacterial extracellular solute-binding proteins, family 3; Region: SBP_bac_3; pfam00497 272562011415 substrate binding pocket [chemical binding]; other site 272562011416 membrane-bound complex binding site; other site 272562011417 hinge residues; other site 272562011418 Ferredoxin [Energy production and conversion]; Region: Fer; COG1141 272562011419 4Fe-4S dicluster domain; Region: Fer4_9; pfam13187 272562011420 Benzoyl-CoA reductase/2-hydroxyglutaryl-CoA dehydratase subunit, BcrC/BadD/HgdB [Amino acid transport and metabolism]; Region: HgdB; COG1775 272562011421 2-hydroxyglutaryl-CoA dehydratase, D-component; Region: HGD-D; pfam06050 272562011422 Activator of 2-hydroxyglutaryl-CoA dehydratase (HSP70-class ATPase domain) [Lipid metabolism]; Region: COG1924 272562011423 6-pyruvoyl tetrahydropterin synthase; Region: PTPS; pfam01242 272562011424 active site 272562011425 putative 7-cyano-7-deazaguanosine (preQ0) biosynthesis protein QueE, clostridial; Region: rSAM_QueE_Clost; TIGR03963 272562011426 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 272562011427 FeS/SAM binding site; other site 272562011428 GTP cyclohydrolase I; Provisional; Region: folE; PRK09347 272562011429 active site 272562011430 ExsB is a transcription regulator related protein. It is a subfamily of a Adenosine nucleotide binding superfamily of proteins. This protein family is represented by a single member in nearly every completed large (> 1000 genes) prokaryotic genome. In...; Region: ExsB; cd01995 272562011431 Ligand Binding Site [chemical binding]; other site 272562011432 oligopeptide ABC transporter ATP-binding protein OppF; Provisional; Region: PRK15079 272562011433 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 272562011434 Walker A/P-loop; other site 272562011435 ATP binding site [chemical binding]; other site 272562011436 Q-loop/lid; other site 272562011437 ABC transporter signature motif; other site 272562011438 Walker B; other site 272562011439 D-loop; other site 272562011440 H-loop/switch region; other site 272562011441 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097 272562011442 ABC-type dipeptide/oligopeptide/nickel transport system, ATPase component [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppD; COG0444 272562011443 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 272562011444 Walker A/P-loop; other site 272562011445 ATP binding site [chemical binding]; other site 272562011446 Q-loop/lid; other site 272562011447 ABC transporter signature motif; other site 272562011448 Walker B; other site 272562011449 D-loop; other site 272562011450 H-loop/switch region; other site 272562011451 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097 272562011452 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppC; COG1173 272562011453 N-terminal TM domain of oligopeptide transport permease C; Region: OppC_N; pfam12911 272562011454 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 272562011455 dimer interface [polypeptide binding]; other site 272562011456 conserved gate region; other site 272562011457 putative PBP binding loops; other site 272562011458 ABC-ATPase subunit interface; other site 272562011459 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppB; COG0601 272562011460 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 272562011461 dimer interface [polypeptide binding]; other site 272562011462 conserved gate region; other site 272562011463 putative PBP binding loops; other site 272562011464 ABC-ATPase subunit interface; other site 272562011465 ABC-type oligopeptide transport system, periplasmic component [Amino acid transport and metabolism]; Region: OppA; COG4166 272562011466 The substrate-binding component of an ABC-type oligopetide import system contains the type 2 periplasmic binding fold; Region: PBP2_OppA; cd08504 272562011467 peptide binding site [polypeptide binding]; other site 272562011468 ABC-type oligopeptide transport system, periplasmic component [Amino acid transport and metabolism]; Region: OppA; COG4166 272562011469 The substrate-binding component of an ABC-type oligopetide import system contains the type 2 periplasmic binding fold; Region: PBP2_OppA; cd08504 272562011470 peptide binding site [polypeptide binding]; other site 272562011471 oligopeptide ABC transporter ATP-binding protein OppF; Provisional; Region: PRK15079 272562011472 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 272562011473 Walker A/P-loop; other site 272562011474 ATP binding site [chemical binding]; other site 272562011475 Q-loop/lid; other site 272562011476 ABC transporter signature motif; other site 272562011477 Walker B; other site 272562011478 D-loop; other site 272562011479 H-loop/switch region; other site 272562011480 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097 272562011481 ABC-type dipeptide/oligopeptide/nickel transport system, ATPase component [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppD; COG0444 272562011482 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 272562011483 Walker A/P-loop; other site 272562011484 ATP binding site [chemical binding]; other site 272562011485 Q-loop/lid; other site 272562011486 ABC transporter signature motif; other site 272562011487 Walker B; other site 272562011488 D-loop; other site 272562011489 H-loop/switch region; other site 272562011490 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097 272562011491 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppC; COG1173 272562011492 N-terminal TM domain of oligopeptide transport permease C; Region: OppC_N; pfam12911 272562011493 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 272562011494 dimer interface [polypeptide binding]; other site 272562011495 conserved gate region; other site 272562011496 putative PBP binding loops; other site 272562011497 ABC-ATPase subunit interface; other site 272562011498 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppB; COG0601 272562011499 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 272562011500 dimer interface [polypeptide binding]; other site 272562011501 conserved gate region; other site 272562011502 putative PBP binding loops; other site 272562011503 ABC-ATPase subunit interface; other site 272562011504 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 272562011505 non-specific DNA binding site [nucleotide binding]; other site 272562011506 salt bridge; other site 272562011507 sequence-specific DNA binding site [nucleotide binding]; other site 272562011508 ABC-type oligopeptide transport system, periplasmic component [Amino acid transport and metabolism]; Region: OppA; COG4166 272562011509 The substrate-binding component of an ABC-type oligopetide import system contains the type 2 periplasmic binding fold; Region: PBP2_OppA; cd08504 272562011510 peptide binding site [polypeptide binding]; other site 272562011511 oligopeptide ABC transporter ATP-binding protein OppF; Provisional; Region: PRK15079 272562011512 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 272562011513 Walker A/P-loop; other site 272562011514 ATP binding site [chemical binding]; other site 272562011515 Q-loop/lid; other site 272562011516 ABC transporter signature motif; other site 272562011517 Walker B; other site 272562011518 D-loop; other site 272562011519 H-loop/switch region; other site 272562011520 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097 272562011521 ABC-type dipeptide/oligopeptide/nickel transport system, ATPase component [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppD; COG0444 272562011522 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 272562011523 Walker A/P-loop; other site 272562011524 ATP binding site [chemical binding]; other site 272562011525 Q-loop/lid; other site 272562011526 ABC transporter signature motif; other site 272562011527 Walker B; other site 272562011528 D-loop; other site 272562011529 H-loop/switch region; other site 272562011530 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097 272562011531 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppC; COG1173 272562011532 N-terminal TM domain of oligopeptide transport permease C; Region: OppC_N; pfam12911 272562011533 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 272562011534 dimer interface [polypeptide binding]; other site 272562011535 conserved gate region; other site 272562011536 putative PBP binding loops; other site 272562011537 ABC-ATPase subunit interface; other site 272562011538 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppB; COG0601 272562011539 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 272562011540 dimer interface [polypeptide binding]; other site 272562011541 conserved gate region; other site 272562011542 putative PBP binding loops; other site 272562011543 ABC-ATPase subunit interface; other site 272562011544 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 272562011545 non-specific DNA binding site [nucleotide binding]; other site 272562011546 salt bridge; other site 272562011547 sequence-specific DNA binding site [nucleotide binding]; other site 272562011548 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 272562011549 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 272562011550 non-specific DNA binding site [nucleotide binding]; other site 272562011551 salt bridge; other site 272562011552 sequence-specific DNA binding site [nucleotide binding]; other site 272562011553 Regulators of stationary/sporulation gene expression [Transcription]; Region: AbrB; COG2002 272562011554 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 272562011555 Coenzyme A binding pocket [chemical binding]; other site 272562011556 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 272562011557 Acetyltransferases [General function prediction only]; Region: RimI; COG0456 272562011558 Coenzyme A binding pocket [chemical binding]; other site 272562011559 Regulators of stationary/sporulation gene expression [Transcription]; Region: AbrB; COG2002 272562011560 c-di-GMP phosphodiesterase class II (HD-GYP domain) [Signal transduction mechanisms]; Region: COG2206 272562011561 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 272562011562 Zn2+ binding site [ion binding]; other site 272562011563 Mg2+ binding site [ion binding]; other site 272562011564 Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain (MocR family) and their eukaryotic orthologs [Transcription / Amino acid transport and metabolism]; Region: ARO8; COG1167 272562011565 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 272562011566 DNA-binding site [nucleotide binding]; DNA binding site 272562011567 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 272562011568 pyridoxal 5'-phosphate binding site [chemical binding]; other site 272562011569 homodimer interface [polypeptide binding]; other site 272562011570 catalytic residue [active] 272562011571 acetolactate synthase; Reviewed; Region: PRK08322 272562011572 Pyrimidine (PYR) binding domain of POX and related proteins; Region: TPP_PYR_POX_like; cd07035 272562011573 PYR/PP interface [polypeptide binding]; other site 272562011574 dimer interface [polypeptide binding]; other site 272562011575 TPP binding site [chemical binding]; other site 272562011576 Thiamine pyrophosphate enzyme, central domain; Region: TPP_enzyme_M; pfam00205 272562011577 Thiamine pyrophosphate (TPP) family, Acetolactate synthase (ALS) subfamily, TPP-binding module; composed of proteins similar to Klebsiella pneumoniae ALS, a catabolic enzyme required for butanediol fermentation. ALS catalyzes the conversion of 2...; Region: TPP_ALS; cd02010 272562011578 TPP-binding site [chemical binding]; other site 272562011579 dimer interface [polypeptide binding]; other site 272562011580 Heavy-metal-associated domain (HMA) is a conserved domain of approximately 30 amino acid residues found in a number of proteins that transport or detoxify heavy metals, for example, the CPx-type heavy metal ATPases and copper chaperones. HMA domain...; Region: HMA; cd00371 272562011581 metal-binding site [ion binding] 272562011582 Heavy-metal-associated domain (HMA) is a conserved domain of approximately 30 amino acid residues found in a number of proteins that transport or detoxify heavy metals, for example, the CPx-type heavy metal ATPases and copper chaperones. HMA domain...; Region: HMA; cd00371 272562011583 metal-binding site [ion binding] 272562011584 Cation transport ATPase [Inorganic ion transport and metabolism]; Region: ZntA; COG2217 272562011585 Heavy-metal-associated domain (HMA) is a conserved domain of approximately 30 amino acid residues found in a number of proteins that transport or detoxify heavy metals, for example, the CPx-type heavy metal ATPases and copper chaperones. HMA domain...; Region: HMA; cd00371 272562011586 metal-binding site [ion binding] 272562011587 E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122 272562011588 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 272562011589 motif II; other site 272562011590 Uncharacterized family 2; belongs to a superfamily containing transcriptional regulators CsoR (copper-sensitive operon repressor), RcnR, and FrmR, and related domains; this family was previously known as part of DUF156; Region: CsoR-like_DUF156_2; cd10159 272562011591 putative homodimer interface [polypeptide binding]; other site 272562011592 putative homotetramer interface [polypeptide binding]; other site 272562011593 putative allosteric switch controlling residues; other site 272562011594 putative metal binding site [ion binding]; other site 272562011595 putative homodimer-homodimer interface [polypeptide binding]; other site 272562011596 NADP+-dependent non-phosphorylating glyceraldehyde 3-phosphate dehydrogenase and ALDH family 11; Region: ALDH_F11_NP-GAPDH; cd07082 272562011597 tetrameric interface [polypeptide binding]; other site 272562011598 activator binding site; other site 272562011599 NADP binding site [chemical binding]; other site 272562011600 substrate binding site [chemical binding]; other site 272562011601 catalytic residues [active] 272562011602 Uncharacterized membrane protein [Function unknown]; Region: SapB; COG1285 272562011603 MgtC family; Region: MgtC; pfam02308 272562011604 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 272562011605 undecaprenyl phosphate 4-deoxy-4-formamido-L-arabinose transferase; Provisional; Region: PRK10714 272562011606 Bacterial DPM1_like enzymes are related to eukaryotic DPM1; Region: DPM1_like_bac; cd04187 272562011607 Ligand binding site; other site 272562011608 Putative Catalytic site; other site 272562011609 DXD motif; other site 272562011610 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 272562011611 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 272562011612 dimerization interface [polypeptide binding]; other site 272562011613 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 272562011614 dimer interface [polypeptide binding]; other site 272562011615 phosphorylation site [posttranslational modification] 272562011616 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 272562011617 ATP binding site [chemical binding]; other site 272562011618 Mg2+ binding site [ion binding]; other site 272562011619 G-X-G motif; other site 272562011620 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 272562011621 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 272562011622 active site 272562011623 phosphorylation site [posttranslational modification] 272562011624 intermolecular recognition site; other site 272562011625 dimerization interface [polypeptide binding]; other site 272562011626 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 272562011627 DNA binding site [nucleotide binding] 272562011628 NADPH-dependent FMN reductase; Region: FMN_red; cl00438 272562011629 Prolyl oligopeptidase family; Region: Peptidase_S9; cl19144 272562011630 Alpha/beta hydrolase family; Region: Abhydrolase_5; pfam12695 272562011631 Prolyl oligopeptidase family; Region: Peptidase_S9; cl19144 272562011632 Membrane transporters of cations and cationic drugs [Inorganic ion transport and metabolism]; Region: EmrE; COG2076 272562011633 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 272562011634 Major Facilitator Superfamily; Region: MFS_1; pfam07690 272562011635 putative substrate translocation pore; other site 272562011636 Transcriptional regulators [Transcription]; Region: MarR; COG1846 272562011637 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cl17220 272562011638 ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395 272562011639 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 272562011640 dimer interface [polypeptide binding]; other site 272562011641 conserved gate region; other site 272562011642 putative PBP binding loops; other site 272562011643 ABC-ATPase subunit interface; other site 272562011644 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 272562011645 dimer interface [polypeptide binding]; other site 272562011646 conserved gate region; other site 272562011647 putative PBP binding loops; other site 272562011648 ABC-ATPase subunit interface; other site 272562011649 ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653 272562011650 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; pfam01547 272562011651 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 272562011652 putative DNA binding site [nucleotide binding]; other site 272562011653 putative Zn2+ binding site [ion binding]; other site 272562011654 Transcriptional regulator/sugar kinase [Transcription / Carbohydrate transport and metabolism]; Region: NagC; COG1940 272562011655 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cl17037 272562011656 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cl17037 272562011657 FOG: CBS domain [General function prediction only]; Region: COG0517 272562011658 The CBS domain, named after human CBS, is a small domain originally identified in cystathionine beta-synthase and is subsequently found in a wide range of different proteins. CBS domains usually occur in tandem repeats. They associate to form a so-called...; Region: CBS_pair_30; cd04643 272562011659 DNA polymerase III subunit beta; Validated; Region: PRK06673 272562011660 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3786 272562011661 DNA-binding transcriptional activator KdpE; Provisional; Region: PRK10529 272562011662 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 272562011663 active site 272562011664 phosphorylation site [posttranslational modification] 272562011665 intermolecular recognition site; other site 272562011666 dimerization interface [polypeptide binding]; other site 272562011667 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 272562011668 DNA binding site [nucleotide binding] 272562011669 Osmosensitive K+ channel histidine kinase [Signal transduction mechanisms]; Region: KdpD; COG2205 272562011670 Osmosensitive K+ channel His kinase sensor domain; Region: KdpD; pfam02702 272562011671 USP domain is located between the N-terminal sensor domain and C-terminal catalytic domain of this Osmosensitive K+ channel histidine kinase family. The family of KdpD sensor kinase proteins regulates the kdpFABC operon responsible for potassium...; Region: USP_OKCHK; cd01987 272562011672 Ligand Binding Site [chemical binding]; other site 272562011673 Domain of unknown function (DUF4118); Region: DUF4118; pfam13493 272562011674 GAF domain; Region: GAF_3; pfam13492 272562011675 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 272562011676 dimer interface [polypeptide binding]; other site 272562011677 phosphorylation site [posttranslational modification] 272562011678 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 272562011679 ATP binding site [chemical binding]; other site 272562011680 Mg2+ binding site [ion binding]; other site 272562011681 G-X-G motif; other site 272562011682 potassium-transporting ATPase subunit C; Provisional; Region: PRK13995 272562011683 potassium-transporting ATPase subunit B; Provisional; Region: PRK01122 272562011684 E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122 272562011685 haloacid dehalogenase-like hydrolase; Region: HAD; pfam12710 272562011686 potassium-transporting ATPase subunit A; Provisional; Region: PRK05482 272562011687 NTF2-like N-terminal transpeptidase domain; Region: MecA_N; pfam05223 272562011688 penicillin-binding protein 2; Region: pbp2_mrdA; TIGR03423 272562011689 Penicillin-binding Protein dimerization domain; Region: PBP_dimer; pfam03717 272562011690 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; pfam00905 272562011691 Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all...; Region: FN3; cd00063 272562011692 Endopygalactorunase [Cell envelope biogenesis, outer membrane]; Region: PGU1; COG5434 272562011693 Pectate lyase superfamily protein; Region: Pectate_lyase_3; cl19188 272562011694 Domain of unknown function (DUF4491); Region: DUF4491; pfam14898 272562011695 Zn-dependent hydrolases, including glyoxylases [General function prediction only]; Region: GloB; COG0491 272562011696 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 272562011697 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 272562011698 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 272562011699 dimerization interface [polypeptide binding]; other site 272562011700 Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer); Region: MA; smart00283 272562011701 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 272562011702 dimer interface [polypeptide binding]; other site 272562011703 putative CheW interface [polypeptide binding]; other site 272562011704 Escherichia coli PhnB and similar proteins; the E. coli phnB gene is found next to an operon involved in the cleavage of carbon-phosphorus bonds in unactivated alkylphosphonates; Region: PhnB_like; cd06588 272562011705 dimer interface [polypeptide binding]; other site 272562011706 Putative hydrophobic ligand-binding SRPBCC domain of an uncharacterized subgroup of CalC- and Aha1-like proteins; Region: SRPBCC_CalC_Aha1-like_4; cd08897 272562011707 putative hydrophobic ligand binding site [chemical binding]; other site 272562011708 Chagasin family peptidase inhibitor I42; Region: Inhibitor_I42; pfam09394 272562011709 Predicted membrane protein [Function unknown]; Region: COG1511 272562011710 YhgE/Pip N-terminal domain; Region: pip_yhgE_Nterm; cl19580 272562011711 SUKH-3 immunity protein; Region: SUKH-3; pfam14433 272562011712 SUKH-3 immunity protein; Region: SUKH-3; pfam14433 272562011713 SUKH-3 immunity protein; Region: SUKH-3; pfam14433 272562011714 NAD+--asparagine ADP-ribosyltransferase [Signal transduction mechanisms]; Region: COG5585 272562011715 YwqJ-like deaminase; Region: YwqJ-deaminase; pfam14431 272562011716 LXG domain of WXG superfamily; Region: LXG; pfam04740 272562011717 NAD+--asparagine ADP-ribosyltransferase [Signal transduction mechanisms]; Region: COG5585 272562011718 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4495 272562011719 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4495 272562011720 type VII secretion protein EssC, C-terminal domain; Region: T7_EssCb_Firm; TIGR03928 272562011721 FtsK/SpoIIIE family; Region: FtsK_SpoIIIE; pfam01580 272562011722 FtsK/SpoIIIE family; Region: FtsK_SpoIIIE; pfam01580 272562011723 Predicted membrane protein [Function unknown]; Region: COG4499 272562011724 WXG100 protein secretion system (Wss), protein YukD; Region: YukD; pfam08817 272562011725 type VII secretion protein EssA; Region: T7SS_EssA_Firm; TIGR03927 272562011726 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4842 272562011727 Molecular chaperone (small heat shock protein) [Posttranslational modification, protein turnover, chaperones]; Region: IbpA; COG0071 272562011728 Group of bacterial proteins containing an alpha crystallin domain (ACD) similar to Lactobacillus plantarum (Lp) small heat shock proteins (sHsp) HSP 18.5, HSP 18.55 and HSP 19.3. sHsps are molecular chaperones that suppress protein aggregation and...; Region: ACD_LpsHSP_like; cd06471 272562011729 putative dimer interface [polypeptide binding]; other site 272562011730 replicative DNA helicase; Provisional; Region: PRK05595 272562011731 DnaB-like helicase N terminal domain; Region: DnaB; pfam00772 272562011732 DnaB helicase C terminal domain. The hexameric helicase DnaB unwinds the DNA duplex at the chromosome replication fork. Although the mechanism by which DnaB both couples ATP hydrolysis to translocation along DNA and denatures the duplex is unknown, a...; Region: DnaB_C; cd00984 272562011733 Walker A motif; other site 272562011734 ATP binding site [chemical binding]; other site 272562011735 Walker B motif; other site 272562011736 DNA binding loops [nucleotide binding] 272562011737 ATP-dependent protease, Lon family; Region: spore_lon_C; TIGR02903 272562011738 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 272562011739 Walker A motif; other site 272562011740 ATP binding site [chemical binding]; other site 272562011741 Walker B motif; other site 272562011742 arginine finger; other site 272562011743 Lon protease (S16) C-terminal proteolytic domain; Region: Lon_C; pfam05362 272562011744 50S ribosomal protein L9; Reviewed; Region: rplI; PRK00137 272562011745 Ribosomal protein L9, N-terminal domain; Region: Ribosomal_L9_N; pfam01281 272562011746 Ribosomal protein L9, C-terminal domain; Region: Ribosomal_L9_C; pfam03948 272562011747 Predicted signaling protein consisting of a modified GGDEF domain and a DHH domain [Signal transduction mechanisms]; Region: COG3887 272562011748 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 272562011749 putative active site [active] 272562011750 heme pocket [chemical binding]; other site 272562011751 DHH family; Region: DHH; pfam01368 272562011752 DHHA1 domain; Region: DHHA1; pfam02272 272562011753 Predicted membrane protein [Function unknown]; Region: COG4241 272562011754 MazG-like family; Region: MazG-like; pfam12643 272562011755 30S ribosomal protein S18; Reviewed; Region: rpsR; PRK00391 272562011756 Single-stranded DNA-binding protein [DNA replication, recombination, and repair]; Region: Ssb; COG0629 272562011757 SSB_OBF: A subfamily of OB folds similar to the OB fold of ssDNA-binding protein (SSB). SSBs bind with high affinity to ssDNA. They bind to and protect ssDNA intermediates during DNA metabolic pathways. All bacterial and eukaryotic SSBs studied to date...; Region: SSB_OBF; cd04496 272562011758 dimer interface [polypeptide binding]; other site 272562011759 ssDNA binding site [nucleotide binding]; other site 272562011760 tetramer (dimer of dimers) interface [polypeptide binding]; other site 272562011761 30S ribosomal protein S6; Reviewed; Region: rpsF; PRK00453 272562011762 Bacterial protein of unknown function (DUF951); Region: DUF951; pfam06107 272562011763 Small-conductance mechanosensitive channel [Cell envelope biogenesis, outer membrane]; Region: MscS; COG0668 272562011764 Mechanosensitive ion channel; Region: MS_channel; pfam00924 272562011765 putative sporulation protein YyaC; Region: spore_YyaC; TIGR02841 272562011766 Protein of unknown function (DUF4446); Region: DUF4446; pfam14584 272562011767 ParB-like nuclease domain; Region: ParB; smart00470 272562011768 ParB/RepB/Spo0J family partition protein; Region: parB_part; TIGR00180 272562011769 ATPases involved in chromosome partitioning [Cell division and chromosome partitioning]; Region: Soj; COG1192 272562011770 ParA and ParB of Caulobacter crescentus belong to a conserved family of bacterial proteins implicated in chromosome segregation. ParB binds to DNA sequences adjacent to the origin of replication and localizes to opposite cell poles shortly following the...; Region: ParA; cd02042 272562011771 P-loop; other site 272562011772 Magnesium ion binding site [ion binding]; other site 272562011773 nucleoid occlusion protein; Region: nucleoid_noc; TIGR04285 272562011774 ParB-like nuclease domain; Region: ParBc; pfam02195 272562011775 Predicted S-adenosylmethionine-dependent methyltransferase involved in bacterial cell division [Cell envelope biogenesis, outer membrane]; Region: GidB; COG0357 272562011776 Methyltransferase domain; Region: Methyltransf_31; pfam13847 272562011777 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 272562011778 S-adenosylmethionine binding site [chemical binding]; other site 272562011779 tRNA uridine 5-carboxymethylaminomethyl modification enzyme GidA; Validated; Region: PRK05192 272562011780 tRNA:m(5)U-54 methyltransferase; Region: gid_trmFO; TIGR00137 272562011781 GidA associated domain 3; Region: GIDA_assoc_3; pfam13932 272562011782 tRNA modification GTPase TrmE; Reviewed; Region: trmE; PRK05291 272562011783 GTP-binding protein TrmE N-terminus; Region: TrmE_N; pfam10396 272562011784 trmE is a tRNA modification GTPase; Region: trmE; cd04164 272562011785 G1 box; other site 272562011786 GTP/Mg2+ binding site [chemical binding]; other site 272562011787 Switch I region; other site 272562011788 G2 box; other site 272562011789 Switch II region; other site 272562011790 G3 box; other site 272562011791 G4 box; other site 272562011792 G5 box; other site 272562011793 Catalytic cysteine-containing C-terminus of GTPase, MnmE; Region: GTPase_Cys_C; pfam12631 272562011794 Predicted RNA-binding protein [General function prediction only]; Region: Jag; COG1847 272562011795 Jag N-terminus; Region: Jag_N; pfam14804 272562011796 jag_K homology RNA-binding domain. The KH domain is found in proteins homologous to the Bacillus subtilis protein Jag, which is associated with SpoIIIJ and is necessary for the third stage of sporulation. The KH motif is a beta-alpha-alpha-beta-beta...; Region: jag_KH; cd02414 272562011797 G-X-X-G motif; other site 272562011798 R3H domain found in proteins homologous to Bacillus subtilus Jag, which is associated with SpoIIIJ. SpoIIIJ is necessary for the third stage of sporulation. The name of the R3H domain comes from the characteristic spacing of the most conserved arginine...; Region: R3H_jag; cd02644 272562011799 RxxxH motif; other site 272562011800 putative inner membrane protein translocase component YidC; Provisional; Region: PRK00145 272562011801 Haemolytic domain; Region: Haemolytic; pfam01809 272562011802 ribonuclease P; Reviewed; Region: rnpA; PRK00499 272562011803 50S ribosomal protein L34; Reviewed; Region: rpmH; PRK00399