-- dump date 20140619_042807 -- class Genbank::misc_feature -- table misc_feature_note -- id note 755731000001 chromosomal replication initiation protein; Reviewed; Region: dnaA; PRK00149 755731000002 DnaA N-terminal domain; Region: DnaA_N; pfam11638 755731000003 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 755731000004 Walker A motif; other site 755731000005 ATP binding site [chemical binding]; other site 755731000006 Walker B motif; other site 755731000007 arginine finger; other site 755731000008 C-terminal domain of bacterial DnaA proteins. The DNA-binding C-terminal domain of DnaA contains a helix-turn-helix motif that specifically interacts with the DnaA box, a 9-mer motif that occurs repetitively in the replication origin oriC. Multiple...; Region: Bac_DnaA_C; cd06571 755731000009 DnaA box-binding interface [nucleotide binding]; other site 755731000010 DNA polymerase III subunit beta; Validated; Region: PRK05643 755731000011 Beta clamp domain. The beta subunit (processivity factor) of DNA polymerase III holoenzyme, refered to as the beta clamp, forms a ring shaped dimer that encircles dsDNA (sliding clamp) in bacteria. The beta-clamp is structurally similar to the trimeric...; Region: beta_clamp; cd00140 755731000012 putative DNA binding surface [nucleotide binding]; other site 755731000013 dimer interface [polypeptide binding]; other site 755731000014 beta-clamp/clamp loader binding surface; other site 755731000015 beta-clamp/translesion DNA polymerase binding surface; other site 755731000016 S4 domain; Region: S4_2; pfam13275 755731000017 recombination protein F; Reviewed; Region: recF; PRK00064 755731000018 ATP-binding cassette domain of RecF; Region: ABC_RecF; cd03242 755731000019 Walker A/P-loop; other site 755731000020 ATP binding site [chemical binding]; other site 755731000021 Q-loop/lid; other site 755731000022 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 755731000023 ABC transporter signature motif; other site 755731000024 Walker B; other site 755731000025 D-loop; other site 755731000026 H-loop/switch region; other site 755731000027 DNA gyrase subunit B; Validated; Region: gyrB; PRK05644 755731000028 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 755731000029 ATP binding site [chemical binding]; other site 755731000030 Mg2+ binding site [ion binding]; other site 755731000031 G-X-G motif; other site 755731000032 TopoIIA_Trans_DNA_gyrase: Transducer domain, having a ribosomal S5 domain 2-like fold, of the type found in proteins of the type IIA family of DNA topoisomerases similar to the B subunits of E. coli DNA gyrase and E. coli Topoisomerase IV which are; Region: TopoII_Trans_DNA_gyrase; cd00822 755731000033 anchoring element; other site 755731000034 dimer interface [polypeptide binding]; other site 755731000035 ATP binding site [chemical binding]; other site 755731000036 TOPRIM_TopoIIA_GyrB: topoisomerase-primase (TOPRIM) nucleotidyl transferase/hydrolase domain of the type found in proteins of the type IIA family of DNA topoisomerases similar to the Escherichia coli GyrB subunit. TopoIIA enzymes cut both strands of the...; Region: TOPRIM_TopoIIA_GyrB; cd03366 755731000037 active site 755731000038 putative metal-binding site [ion binding]; other site 755731000039 DNA gyrase B subunit, carboxyl terminus; Region: DNA_gyraseB_C; pfam00986 755731000040 ATPases involved in chromosome partitioning [Cell division and chromosome partitioning]; Region: Soj; COG1192 755731000041 ParA and ParB of Caulobacter crescentus belong to a conserved family of bacterial proteins implicated in chromosome segregation. ParB binds to DNA sequences adjacent to the origin of replication and localizes to opposite cell poles shortly following the...; Region: ParA; cd02042 755731000042 P-loop; other site 755731000043 Magnesium ion binding site [ion binding]; other site 755731000044 ParB/RepB/Spo0J family partition protein; Region: parB_part; TIGR00180 755731000045 ParB-like nuclease domain; Region: ParB; smart00470 755731000046 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG1729 755731000047 Phosphatidylserine synthase [Lipid metabolism]; Region: PssA; COG1183 755731000048 CDP-alcohol phosphatidyltransferase; Region: CDP-OH_P_transf; pfam01066 755731000049 pyrophosphatase PpaX; Provisional; Region: PRK13288 755731000050 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 755731000051 active site 755731000052 motif I; other site 755731000053 motif II; other site 755731000054 Uncharacterized conserved protein (DUF2203); Region: DUF2203; cl02056 755731000055 pyruvate:ferredoxin (flavodoxin) oxidoreductase, homodimeric; Region: pyruv_ox_red; TIGR02176 755731000056 Pyrimidine (PYR) binding domain of pyruvate ferredoxin oxidoreductase (PFOR), indolepyruvate ferredoxin oxidoreductase alpha subunit (IOR-alpha), and related proteins; Region: TPP_PYR_PFOR_IOR-alpha_like; cd07034 755731000057 dimer interface [polypeptide binding]; other site 755731000058 PYR/PP interface [polypeptide binding]; other site 755731000059 TPP binding site [chemical binding]; other site 755731000060 substrate binding site [chemical binding]; other site 755731000061 Transketolase, C-terminal domain; Region: Transketolase_C; pfam02780 755731000062 Pyruvate:ferredoxin oxidoreductase and related 2-oxoacid:ferredoxin oxidoreductases, gamma subunit [Energy production and conversion]; Region: PorG; COG1014 755731000063 Domain of unknown function; Region: EKR; pfam10371 755731000064 The HCP family of iron-sulfur proteins includes hybrid cluster protein (HCP), acetyl-CoA synthase (ACS), and carbon monoxide dehydrogenase (CODH), all of which contain [Fe4-S4] metal clusters at their active sites. These proteins have a conserved...; Region: HCP_like; cl14655 755731000065 Thiamine pyrophosphate (TPP family), PFOR_PNO subfamily, TPP-binding module; composed of proteins similar to the single subunit pyruvate ferredoxin oxidoreductase (PFOR) of Desulfovibrio Africanus, present in bacteria and amitochondriate eukaryotes. This...; Region: TPP_PFOR_PNO; cd03377 755731000066 TPP-binding site [chemical binding]; other site 755731000067 dimer interface [polypeptide binding]; other site 755731000068 Dolichyl-phosphate-mannose-protein mannosyltransferase; Region: PMT_2; pfam13231 755731000069 spore coat protein, CotS family; Region: spore_CotS; TIGR02906 755731000070 spore coat protein YsxE; Region: spore_ysxE; TIGR02904 755731000071 formate--tetrahydrofolate ligase; Provisional; Region: PRK13505 755731000072 Formyltetrahydrofolate synthetase (FTHFS) catalyzes the ATP-dependent activation of formate ion via its addition to the N10 position of tetrahydrofolate. FTHFS is a highly expressed key enzyme in both the Wood-Ljungdahl pathway of autotrophic CO2...; Region: FTHFS; cd00477 755731000073 Potassium binding sites [ion binding]; other site 755731000074 Cesium cation binding sites [ion binding]; other site 755731000075 YabG peptidase U57; Region: Peptidase_U57; cl05250 755731000076 Protein of unknown function (DUF1021); Region: DUF1021; pfam06257 755731000077 Domain of unknown function (DUF3794); Region: DUF3794; pfam12673 755731000078 Domain of unknown function (DUF3794); Region: DUF3794; pfam12673 755731000079 Domain of unknown function (DUF3794); Region: DUF3794; pfam12673 755731000080 FOG: LysM repeat [Cell envelope biogenesis, outer membrane]; Region: LytE; COG1388 755731000081 Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118 755731000082 4-diphosphocytidyl-2-C-methyl-D-erythritol kinase; Provisional; Region: ipk; PRK00128 755731000083 GHMP kinases N terminal domain; Region: GHMP_kinases_N; pfam00288 755731000084 GHMP kinases C terminal; Region: GHMP_kinases_C; pfam08544 755731000085 Transcriptional regulators [Transcription]; Region: GntR; COG1802 755731000086 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 755731000087 DNA-binding site [nucleotide binding]; DNA binding site 755731000088 FCD domain; Region: FCD; pfam07729 755731000089 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 755731000090 ATPases associated with a variety of cellular activities; Region: AAA; smart00382 755731000091 Walker A motif; other site 755731000092 ATP binding site [chemical binding]; other site 755731000093 Walker B motif; other site 755731000094 arginine finger; other site 755731000095 Phage shock protein A (IM30), suppresses sigma54-dependent transcription [Transcription / Signal transduction mechanisms]; Region: PspA; COG1842 755731000096 Sortase and related acyltransferases [Cell envelope biogenesis, outer membrane]; Region: COG1247 755731000097 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 755731000098 Coenzyme A binding pocket [chemical binding]; other site 755731000099 Protein of unknown function (DUF342); Region: DUF342; pfam03961 755731000100 GAF domain; Region: GAF_3; pfam13492 755731000101 GAF domain; Region: GAF_3; pfam13492 755731000102 4'-phosphopantetheinyl transferase; Provisional; Region: acpS; PRK00070 755731000103 Mre11 nuclease, N-terminal metallophosphatase domain; Region: MPP_Mre11_N; cd00840 755731000104 Calcineurin-like phosphoesterase; Region: Metallophos; pfam00149 755731000105 active site 755731000106 metal binding site [ion binding]; metal-binding site 755731000107 DNA binding site [nucleotide binding] 755731000108 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 755731000109 AAA domain; Region: AAA_23; pfam13476 755731000110 Walker A/P-loop; other site 755731000111 ATP binding site [chemical binding]; other site 755731000112 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 755731000113 Q-loop/lid; other site 755731000114 ABC transporter signature motif; other site 755731000115 Walker B; other site 755731000116 D-loop; other site 755731000117 H-loop/switch region; other site 755731000118 Bacterial SH3 domain; Region: SH3_3; cl17532 755731000119 NlpC/P60 family; Region: NLPC_P60; pfam00877 755731000120 diacylglycerol glucosyltransferase; Provisional; Region: PRK13609 755731000121 Monogalactosyldiacylglycerol (MGDG) synthase; Region: MGDG_synth; pfam06925 755731000122 Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013 755731000123 spore cortex-lytic enzyme; Region: spore_SleB; TIGR02869 755731000124 Putative peptidoglycan binding domain; Region: PG_binding_1; pfam01471 755731000125 Cell Wall Hydrolase; Region: Hydrolase_2; pfam07486 755731000126 germination protein YpeB; Region: spore_YpeB; TIGR02889 755731000127 helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347 755731000128 MarR family; Region: MarR_2; pfam12802 755731000129 Polypeptide or peptide deformylase; a family of metalloenzymes that catalyzes the removal of the N-terminal formyl group in a growing polypeptide chain following translation initiation during protein synthesis in prokaryotes. These enzymes utilize Fe(II)...; Region: Pep_deformylase; cd00487 755731000130 active site 755731000131 catalytic residues [active] 755731000132 metal binding site [ion binding]; metal-binding site 755731000133 Methyltransferase domain; Region: Methyltransf_31; pfam13847 755731000134 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 755731000135 S-adenosylmethionine binding site [chemical binding]; other site 755731000136 S-layer homology domain; Region: SLH; pfam00395 755731000137 S-layer homology domain; Region: SLH; pfam00395 755731000138 Intracellular proteinase inhibitor; Region: BsuPI; pfam12690 755731000139 CAAX protease self-immunity; Region: Abi; pfam02517 755731000140 DNA replication protein DnaC; Validated; Region: PRK06835 755731000141 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 755731000142 Walker A motif; other site 755731000143 ATP binding site [chemical binding]; other site 755731000144 Walker B motif; other site 755731000145 Replication initiation and membrane attachment; Region: DnaB_2; pfam07261 755731000146 Replication initiation and membrane attachment; Region: DnaB_2; pfam07261 755731000147 Ammonia permease [Inorganic ion transport and metabolism]; Region: AmtB; COG0004 755731000148 Nitrogen regulatory protein PII [Amino acid transport and metabolism]; Region: GlnK; COG0347 755731000149 Nitrogen regulatory protein P-II; Region: P-II; smart00938 755731000150 nonheme-containing ferritins; Region: Nonheme_Ferritin; cd01055 755731000151 Ferritin-like domain; Region: Ferritin; pfam00210 755731000152 ferroxidase diiron center [ion binding]; other site 755731000153 ABC-type oligopeptide transport system, periplasmic component [Amino acid transport and metabolism]; Region: OppA; COG4166 755731000154 The substrate-binding component of an ABC-type oligopetide import system contains the type 2 periplasmic binding fold; Region: PBP2_OppA; cd08504 755731000155 peptide binding site [polypeptide binding]; other site 755731000156 ABC-type oligopeptide transport system, ATPase component [Amino acid transport and metabolism]; Region: AppF; COG4608 755731000157 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 755731000158 Walker A/P-loop; other site 755731000159 ATP binding site [chemical binding]; other site 755731000160 Q-loop/lid; other site 755731000161 ABC transporter signature motif; other site 755731000162 Walker B; other site 755731000163 D-loop; other site 755731000164 H-loop/switch region; other site 755731000165 oligopeptide/dipeptide ABC transporter, ATP-binding protein, C-terminal domain; Region: oligo_HPY; TIGR01727 755731000166 ABC-type dipeptide/oligopeptide/nickel transport system, ATPase component [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppD; COG0444 755731000167 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 755731000168 Walker A/P-loop; other site 755731000169 ATP binding site [chemical binding]; other site 755731000170 Q-loop/lid; other site 755731000171 ABC transporter signature motif; other site 755731000172 Walker B; other site 755731000173 D-loop; other site 755731000174 H-loop/switch region; other site 755731000175 oligopeptide/dipeptide ABC transporter, ATP-binding protein, C-terminal domain; Region: oligo_HPY; TIGR01727 755731000176 N-terminal TM domain of oligopeptide transport permease C; Region: OppC_N; pfam12911 755731000177 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppC; COG1173 755731000178 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 755731000179 putative PBP binding loops; other site 755731000180 dimer interface [polypeptide binding]; other site 755731000181 ABC-ATPase subunit interface; other site 755731000182 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppB; COG0601 755731000183 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 755731000184 dimer interface [polypeptide binding]; other site 755731000185 conserved gate region; other site 755731000186 putative PBP binding loops; other site 755731000187 ABC-ATPase subunit interface; other site 755731000188 Four helix bundle sensory module for signal transduction; Region: 4HB_MCP_1; pfam12729 755731000189 Methyl-accepting chemotaxis protein [Cell motility and secretion / Signal transduction mechanisms]; Region: Tar; COG0840 755731000190 HAMP domain; Region: HAMP; pfam00672 755731000191 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 755731000192 dimer interface [polypeptide binding]; other site 755731000193 putative CheW interface [polypeptide binding]; other site 755731000194 Sphingosine kinase and enzymes related to eukaryotic diacylglycerol kinase [Lipid metabolism / General function prediction only]; Region: LCB5; COG1597 755731000195 Diacylglycerol kinase catalytic domain; Region: DAGK_cat; pfam00781 755731000196 DNA repair exonuclease [DNA replication, recombination, and repair]; Region: SbcD; COG0420 755731000197 Mre11 nuclease, N-terminal metallophosphatase domain; Region: MPP_Mre11_N; cd00840 755731000198 active site 755731000199 metal binding site [ion binding]; metal-binding site 755731000200 DNA binding site [nucleotide binding] 755731000201 Type 5 capsule protein repressor C-terminal domain; Region: SbcD_C; pfam12320 755731000202 ATPase involved in DNA repair [DNA replication, recombination, and repair]; Region: SbcC; COG0419 755731000203 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 755731000204 Walker A/P-loop; other site 755731000205 ATP binding site [chemical binding]; other site 755731000206 Q-loop/lid; other site 755731000207 Archaeal/eukaryotic core primase: Large subunit, PriL; Region: PriL; cl11970 755731000208 PriL-PriS interface [polypeptide binding]; other site 755731000209 ATP-binding cassette domain of sbcCD; Region: ABC_sbcCD; cd03279 755731000210 ABC transporter signature motif; other site 755731000211 Walker B; other site 755731000212 D-loop; other site 755731000213 H-loop/switch region; other site 755731000214 glycogen branching enzyme; Provisional; Region: PRK05402 755731000215 Early set domain associated with the catalytic domain of sugar utilizing enzymes at either the N or C terminus; Region: E_set; cl09101 755731000216 N-terminal Early set domain associated with the catalytic domain of prokaryotic glycogen branching enzyme; Region: E_set_GBE_prok_N; cd02855 755731000217 Alpha amylase catalytic domain found in the Glycogen branching enzyme (also called 1,4-alpha-glucan branching enzyme); Region: AmyAc_Glg_BE; cd11322 755731000218 active site 755731000219 catalytic site [active] 755731000220 Alpha amylase, C-terminal all-beta domain; Region: Alpha-amylase_C; pfam02806 755731000221 D-xylose transporter subunit XylF; Provisional; Region: xylF; PRK10355 755731000222 Periplasmic xylose-binding component of the ABC-type transport systems that belong to a family of pentose/hexose sugar-binding proteins of the type I periplasmic binding protein (PBP1) superfamily; Region: PBP1_ABC_xylose_binding; cd01538 755731000223 putative ligand binding site [chemical binding]; other site 755731000224 Protein of unknown function (DUF3793); Region: DUF3793; pfam12672 755731000225 Flavodoxin-like fold; Region: Flavodoxin_2; cl00438 755731000226 Uncharacterized protein conserved in bacteria (DUF2325); Region: DUF2325; pfam10087 755731000227 Ribosomal protein S6; Region: Ribosomal_S6; pfam01250 755731000228 Single-stranded DNA-binding protein [DNA replication, recombination, and repair]; Region: Ssb; COG0629 755731000229 SSB_OBF: A subfamily of OB folds similar to the OB fold of ssDNA-binding protein (SSB). SSBs bind with high affinity to ssDNA. They bind to and protect ssDNA intermediates during DNA metabolic pathways. All bacterial and eukaryotic SSBs studied to date...; Region: SSB_OBF; cd04496 755731000230 dimer interface [polypeptide binding]; other site 755731000231 ssDNA binding site [nucleotide binding]; other site 755731000232 tetramer (dimer of dimers) interface [polypeptide binding]; other site 755731000233 30S ribosomal protein S18; Reviewed; Region: rpsR; PRK00391 755731000234 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 755731000235 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 755731000236 active site 755731000237 phosphorylation site [posttranslational modification] 755731000238 intermolecular recognition site; other site 755731000239 dimerization interface [polypeptide binding]; other site 755731000240 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 755731000241 DNA binding site [nucleotide binding] 755731000242 Dockerin type I repeat; Region: Dockerin_1; pfam00404 755731000243 Domain of unknown function (DUF4353); Region: DUF4353; pfam14262 755731000244 Conserved hypothetical protein (DUF2461); Region: DUF2461; pfam09365 755731000245 Domain of unknown function (DUF2007); Region: DUF2007; pfam09413 755731000246 Prephenate dehydratase [Amino acid transport and metabolism]; Region: PheA; COG0077 755731000247 Prephenate dehydratase; Region: PDT; pfam00800 755731000248 C-terminal ACT domain of the bifunctional chorismate mutase-prephenate dehydratase (CM-PDT) enzyme and the prephenate dehydratase (PDT) enzyme; Region: ACT_CM-PDT; cd04905 755731000249 putative L-Phe binding site [chemical binding]; other site 755731000250 MazG-like family; Region: MazG-like; pfam12643 755731000251 Predicted signaling protein consisting of a modified GGDEF domain and a DHH domain [Signal transduction mechanisms]; Region: COG3887 755731000252 cyclase homology domain; Region: CHD; cd07302 755731000253 nucleotidyl binding site; other site 755731000254 dimer interface [polypeptide binding]; other site 755731000255 metal binding site [ion binding]; metal-binding site 755731000256 DHH family; Region: DHH; pfam01368 755731000257 DHHA1 domain; Region: DHHA1; pfam02272 755731000258 50S ribosomal protein L9; Reviewed; Region: rplI; PRK00137 755731000259 Ribosomal protein L9, N-terminal domain; Region: Ribosomal_L9_N; pfam01281 755731000260 Ribosomal protein L9, C-terminal domain; Region: Ribosomal_L9_C; pfam03948 755731000261 replicative DNA helicase; Region: DnaB; TIGR00665 755731000262 DnaB-like helicase N terminal domain; Region: DnaB; pfam00772 755731000263 DnaB helicase C terminal domain. The hexameric helicase DnaB unwinds the DNA duplex at the chromosome replication fork. Although the mechanism by which DnaB both couples ATP hydrolysis to translocation along DNA and denatures the duplex is unknown, a...; Region: DnaB_C; cd00984 755731000264 Walker A motif; other site 755731000265 ATP binding site [chemical binding]; other site 755731000266 Walker B motif; other site 755731000267 DNA binding loops [nucleotide binding] 755731000268 tRNA(Ile)-lysidine synthase MesJ [Cell cycle control, cell division, chromosome partitioning]; Region: MesJ; COG0037 755731000269 N-terminal domain of predicted ATPase of the PP-loop faimly implicated in cell cycle control [Cell division and chromosome partitioning]. This is a subfamily of Adenine nucleotide alpha hydrolases superfamily.Adeninosine nucleotide alpha hydrolases...; Region: PP-ATPase; cd01992 755731000270 Ligand Binding Site [chemical binding]; other site 755731000271 TilS substrate C-terminal domain; Region: TilS_C; smart00977 755731000272 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 755731000273 active site 755731000274 FtsH Extracellular; Region: FtsH_ext; pfam06480 755731000275 ATP-dependent metalloprotease FtsH; Region: FtsH_fam; TIGR01241 755731000276 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 755731000277 Walker A motif; other site 755731000278 ATP binding site [chemical binding]; other site 755731000279 Walker B motif; other site 755731000280 arginine finger; other site 755731000281 Peptidase family M41; Region: Peptidase_M41; pfam01434 755731000282 PaaI_thioesterase is a tetrameric acyl-CoA thioesterase with a hot dog fold and one of several proteins responsible for phenylacetic acid (PA) degradation in bacteria. Although orthologs of PaaI exist in archaea and eukaryotes, their function has not...; Region: PaaI_thioesterase; cd03443 755731000283 subunit interaction site [polypeptide binding]; other site 755731000284 PHB binding site; other site 755731000285 CoenzymeA binding site [chemical binding]; other site 755731000286 S-adenosylmethionine synthetase; Validated; Region: PRK05250 755731000287 S-adenosylmethionine synthetase, N-terminal domain; Region: S-AdoMet_synt_N; pfam00438 755731000288 S-adenosylmethionine synthetase, central domain; Region: S-AdoMet_synt_M; pfam02772 755731000289 S-adenosylmethionine synthetase, C-terminal domain; Region: S-AdoMet_synt_C; pfam02773 755731000290 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394 755731000291 helicase, putative, RecD/TraA family; Region: recD_rel; TIGR01448 755731000292 AAA domain; Region: AAA_30; pfam13604 755731000293 Family description; Region: UvrD_C_2; pfam13538 755731000294 Predicted amidophosphoribosyltransferases [General function prediction only]; Region: ComFC; COG1040 755731000295 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 755731000296 active site 755731000297 flagellar operon protein TIGR03826; Region: YvyF 755731000298 Anti-sigma-28 factor, FlgM; Region: FlgM; pfam04316 755731000299 FlgN protein; Region: FlgN; pfam05130 755731000300 flagellar hook-associated protein FlgK; Region: flgK_ends; TIGR02492 755731000301 Von Willebrand factor type A (vWA) domain was originally found in the blood coagulation protein von Willebrand factor (vWF). Typically, the vWA domain is made up of approximately 200 amino acid residues folded into a classic a/b para-rossmann type of...; Region: vWFA; cd00198 755731000302 metal ion-dependent adhesion site (MIDAS); other site 755731000303 Flagellar basal body rod FlgEFG protein C-terminal; Region: Flg_bbr_C; pfam06429 755731000304 flagellar hook-associated protein FlgK; Validated; Region: flgK; PRK07739 755731000305 Flagella basal body rod protein; Region: Flg_bb_rod; pfam00460 755731000306 Flagellar basal body rod FlgEFG protein C-terminal; Region: Flg_bbr_C; pfam06429 755731000307 flagellar hook-associated protein FlgL; Validated; Region: flgL; PRK07701 755731000308 Bacterial flagellin N-terminal helical region; Region: Flagellin_N; pfam00669 755731000309 Bacterial flagellin C-terminal helical region; Region: Flagellin_C; pfam00700 755731000310 FliW protein; Region: FliW; cl00740 755731000311 carbon storage regulator; Provisional; Region: PRK01712 755731000312 flagellin; Provisional; Region: PRK12804 755731000313 Bacterial flagellin N-terminal helical region; Region: Flagellin_N; pfam00669 755731000314 Bacterial flagellin C-terminal helical region; Region: Flagellin_C; pfam00700 755731000315 FlaG protein; Region: FlaG; pfam03646 755731000316 Flagellar hook-associated protein 2 C-terminus; Region: FliD_N; pfam02465 755731000317 Flagellar hook-associated protein 2 C-terminus; Region: FliD_C; pfam07195 755731000318 Flagellin-specific chaperone FliS [Cell motility and secretion / Intracellular trafficking and secretion / Posttranslational modification, protein turnover, chaperones]; Region: FliS; COG1516 755731000319 FlgN protein; Region: FlgN; pfam05130 755731000320 Kelch motif; Region: Kelch_1; pfam01344 755731000321 Galactose oxidase, central domain; Region: Kelch_4; pfam13418 755731000322 Kelch domain; Region: Kelch; smart00612 755731000323 Kelch domain; Region: Kelch; smart00612 755731000324 Galactose oxidase, central domain; Region: Kelch_4; pfam13418 755731000325 Kelch motif; Region: Kelch_1; pfam01344 755731000326 Kelch motif; Region: Kelch_1; pfam01344 755731000327 Kelch domain; Region: Kelch; smart00612 755731000328 Putative lysophospholipase; Region: Hydrolase_4; pfam12146 755731000329 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 755731000330 Radical SAM superfamily; Region: Radical_SAM; pfam04055 755731000331 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 755731000332 FeS/SAM binding site; other site 755731000333 Protein kinase domain; Region: Pkinase; pfam00069 755731000334 Catalytic domain of Protein Kinases; Region: PKc; cd00180 755731000335 active site 755731000336 ATP binding site [chemical binding]; other site 755731000337 substrate binding site [chemical binding]; other site 755731000338 activation loop (A-loop); other site 755731000339 CobQ/CobB/MinD/ParA nucleotide binding domain; Region: CbiA; pfam01656 755731000340 Flp pilus assembly protein CpaB [Intracellular trafficking and secretion]; Region: CpaB; COG3745 755731000341 SAF domains of the flagella basal body P-ring formation protein FlgA and the flp pilus assembly CpaB; Region: SAF_CpaB_FlgA_like; cd11614 755731000342 AAA domain; Region: AAA_31; pfam13614 755731000343 Type IV secretory pathway, VirB11 components, and related ATPases involved in archaeal flagella biosynthesis [Cell motility and secretion / Intracellular trafficking and secretion]; Region: VirB11; COG0630 755731000344 RecA-like NTPases. This family includes the NTP binding domain of F1 and V1 H+ATPases, DnaB and related helicases as well as bacterial RecA and related eukaryotic and archaeal recombinases. This group also includes bacterial conjugation proteins and...; Region: RecA-like_NTPases; cl17233 755731000345 Walker A motif; other site 755731000346 ATP binding site [chemical binding]; other site 755731000347 Walker B motif; other site 755731000348 helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347 755731000349 MarR family; Region: MarR; pfam01047 755731000350 Glutathione (GSH) peroxidase family; tetrameric selenoenzymes that catalyze the reduction of a variety of hydroperoxides including lipid peroxidases, using GSH as a specific electron donor substrate. GSH peroxidase contains one selenocysteine residue per...; Region: GSH_Peroxidase; cd00340 755731000351 catalytic residues [active] 755731000352 dimer interface [polypeptide binding]; other site 755731000353 Predicted Fe-S oxidoreductases [General function prediction only]; Region: COG0535 755731000354 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 755731000355 FeS/SAM binding site; other site 755731000356 Domain of unknown function (DUF4008); Region: DUF4008; pfam13186 755731000357 ATPase components of ABC transporters with duplicated ATPase domains [General function prediction only]; Region: Uup; COG0488 755731000358 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 755731000359 Walker A/P-loop; other site 755731000360 ATP binding site [chemical binding]; other site 755731000361 Q-loop/lid; other site 755731000362 ABC transporter signature motif; other site 755731000363 Walker B; other site 755731000364 D-loop; other site 755731000365 H-loop/switch region; other site 755731000366 ABC transporter; Region: ABC_tran_2; pfam12848 755731000367 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 755731000368 ATP-dependent RNA helicase SrmB; Provisional; Region: PRK11192 755731000369 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cl17251 755731000370 ATP binding site [chemical binding]; other site 755731000371 putative Mg++ binding site [ion binding]; other site 755731000372 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 755731000373 nucleotide binding region [chemical binding]; other site 755731000374 ATP-binding site [chemical binding]; other site 755731000375 AraC-like ligand binding domain; Region: AraC_binding; pfam02311 755731000376 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 755731000377 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 755731000378 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 755731000379 3-isopropylmalate dehydratase large subunit; Reviewed; Region: PRK00402 755731000380 3-isopropylmalate dehydratase catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate; Region: IPMI; cd01583 755731000381 substrate binding site [chemical binding]; other site 755731000382 ligand binding site [chemical binding]; other site 755731000383 3-isopropylmalate dehydratase small subunit; Reviewed; Region: leuD; PRK00439 755731000384 Aconatase-like swivel domain of 3-isopropylmalate dehydratase and related uncharacterized proteins. 3-isopropylmalate dehydratase catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate...; Region: IPMI_Swivel; cd01577 755731000385 substrate binding site [chemical binding]; other site 755731000386 3-isopropylmalate dehydrogenase; Provisional; Region: PRK00772 755731000387 tartrate dehydrogenase; Region: TTC; TIGR02089 755731000388 Isochorismatase family; Region: Isochorismatase; pfam00857 755731000389 Nicotinamidase_ related amidohydrolases. Cysteine hydrolases of unknown function that share the catalytic triad with other amidohydrolases, like nicotinamidase, which converts nicotinamide to nicotinic acid and ammonia; Region: nicotinamidase_related; cd01014 755731000390 catalytic triad [active] 755731000391 conserved cis-peptide bond; other site 755731000392 D-alanyl-D-alanine carboxypeptidase; Region: VanY; pfam02557 755731000393 Type 1 glutamine amidotransferase (GATase1)-like domain found in cyanophycinase; Region: GAT1_cyanophycinase; cd03145 755731000394 proposed catalytic triad [active] 755731000395 active site nucleophile [active] 755731000396 cyanophycin synthetase; Provisional; Region: PRK14016 755731000397 ATP-grasp domain; Region: ATP-grasp_4; cl17255 755731000398 ATP-grasp domain; Region: ATP-grasp_4; cl17255 755731000399 Mur ligase middle domain; Region: Mur_ligase_M; pfam08245 755731000400 Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875 755731000401 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 755731000402 putative DNA binding site [nucleotide binding]; other site 755731000403 putative Zn2+ binding site [ion binding]; other site 755731000404 Biotin-(acetyl-CoA carboxylase) ligase [Coenzyme metabolism]; Region: BirA; COG0340 755731000405 Biotin/lipoate A/B protein ligase family; Region: BPL_LplA_LipB; pfam03099 755731000406 Biotin protein ligase C terminal domain; Region: BPL_C; pfam02237 755731000407 pantothenate kinase; Reviewed; Region: PRK13318 755731000408 L-lactate dehydrogenase; Reviewed; Region: ldh; PRK00066 755731000409 A subgroup of L-lactate dehydrogenases; Region: LDH_2; cd05292 755731000410 NAD binding site [chemical binding]; other site 755731000411 dimer interface [polypeptide binding]; other site 755731000412 substrate binding site [chemical binding]; other site 755731000413 tetramer (dimer of dimers) interface [polypeptide binding]; other site 755731000414 Malic enzyme [Energy production and conversion]; Region: SfcA; COG0281 755731000415 Malic enzyme, N-terminal domain; Region: malic; pfam00390 755731000416 NAD(P) binding domain of malic enzyme (ME), subgroup 2; Region: NAD_bind_2_malic_enz; cd05311 755731000417 putative NAD(P) binding site [chemical binding]; other site 755731000418 Mannitol-1-phosphate/altronate dehydrogenases [Carbohydrate transport and metabolism]; Region: MtlD; COG0246 755731000419 Mannitol dehydrogenase Rossmann domain; Region: Mannitol_dh; pfam01232 755731000420 Mannitol dehydrogenase C-terminal domain; Region: Mannitol_dh_C; pfam08125 755731000421 mannonate dehydratase; Provisional; Region: PRK03906 755731000422 mannonate dehydratase; Region: uxuA; TIGR00695 755731000423 Alpha-glucuronidase [Carbohydrate transport and metabolism]; Region: AguA; COG3661 755731000424 Glycosyl hydrolase family 67 N-terminus; Region: Glyco_hydro_67N; pfam03648 755731000425 Glycosyl hydrolase family 67 C-terminus; Region: Glyco_hydro_67C; pfam07477 755731000426 Predicted Zn-dependent proteases and their inactivated homologs [General function prediction only]; Region: TldD; COG0312 755731000427 Putative modulator of DNA gyrase; Region: PmbA_TldD; pfam01523 755731000428 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 755731000429 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 755731000430 ABC-type polysaccharide transport system, permease component [Carbohydrate transport and metabolism]; Region: LplB; COG4209 755731000431 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 755731000432 dimer interface [polypeptide binding]; other site 755731000433 conserved gate region; other site 755731000434 ABC-ATPase subunit interface; other site 755731000435 ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395 755731000436 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 755731000437 dimer interface [polypeptide binding]; other site 755731000438 conserved gate region; other site 755731000439 putative PBP binding loops; other site 755731000440 ABC-ATPase subunit interface; other site 755731000441 ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653 755731000442 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; pfam01547 755731000443 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 755731000444 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 755731000445 dimerization interface [polypeptide binding]; other site 755731000446 Histidine kinase; Region: His_kinase; pfam06580 755731000447 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 755731000448 ATP binding site [chemical binding]; other site 755731000449 Mg2+ binding site [ion binding]; other site 755731000450 G-X-G motif; other site 755731000451 Response regulator containing CheY-like receiver domain and AraC-type DNA-binding domain [Signal transduction mechanisms]; Region: COG4753 755731000452 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 755731000453 active site 755731000454 phosphorylation site [posttranslational modification] 755731000455 intermolecular recognition site; other site 755731000456 dimerization interface [polypeptide binding]; other site 755731000457 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 755731000458 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 755731000459 ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653 755731000460 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; pfam01547 755731000461 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 755731000462 dimer interface [polypeptide binding]; other site 755731000463 conserved gate region; other site 755731000464 putative PBP binding loops; other site 755731000465 ABC-ATPase subunit interface; other site 755731000466 ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395 755731000467 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 755731000468 dimer interface [polypeptide binding]; other site 755731000469 conserved gate region; other site 755731000470 putative PBP binding loops; other site 755731000471 ABC-ATPase subunit interface; other site 755731000472 Predicted xylanase/chitin deacetylase [Carbohydrate transport and metabolism]; Region: CDA1; COG0726 755731000473 Putative catalytic NodB homology domain of gellan lyase and similar proteins; Region: CE4_GLA_like_6s; cd10967 755731000474 putative active site [active] 755731000475 putative metal binding site [ion binding]; other site 755731000476 Response regulator containing CheY-like receiver domain and AraC-type DNA-binding domain [Signal transduction mechanisms]; Region: COG4753 755731000477 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 755731000478 active site 755731000479 phosphorylation site [posttranslational modification] 755731000480 intermolecular recognition site; other site 755731000481 dimerization interface [polypeptide binding]; other site 755731000482 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 755731000483 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 755731000484 Predicted signal transduction protein with a C-terminal ATPase domain [Signal transduction mechanisms]; Region: COG2972 755731000485 Histidine kinase; Region: His_kinase; pfam06580 755731000486 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 755731000487 ATP binding site [chemical binding]; other site 755731000488 Mg2+ binding site [ion binding]; other site 755731000489 G-X-G motif; other site 755731000490 Response regulator containing CheY-like receiver domain and AraC-type DNA-binding domain [Signal transduction mechanisms]; Region: COG4753 755731000491 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 755731000492 active site 755731000493 phosphorylation site [posttranslational modification] 755731000494 intermolecular recognition site; other site 755731000495 dimerization interface [polypeptide binding]; other site 755731000496 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 755731000497 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 755731000498 ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653 755731000499 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; pfam01547 755731000500 ABC-type polysaccharide transport system, permease component [Carbohydrate transport and metabolism]; Region: LplB; COG4209 755731000501 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 755731000502 dimer interface [polypeptide binding]; other site 755731000503 conserved gate region; other site 755731000504 putative PBP binding loops; other site 755731000505 ABC-ATPase subunit interface; other site 755731000506 ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395 755731000507 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 755731000508 dimer interface [polypeptide binding]; other site 755731000509 ABC-ATPase subunit interface; other site 755731000510 Glycosyl hydrolase family 10; Region: Glyco_hydro_10; cl01495 755731000511 cryptic beta-D-galactosidase subunit alpha; Reviewed; Region: ebgA; PRK10340 755731000512 Glycosyl hydrolases family 2, sugar binding domain; Region: Glyco_hydro_2_N; pfam02837 755731000513 Glycosyl hydrolases family 2; Region: Glyco_hydro_2; pfam00703 755731000514 Glycosyl hydrolases family 2, TIM barrel domain; Region: Glyco_hydro_2_C; pfam02836 755731000515 Beta galactosidase small chain; Region: Bgal_small_N; smart01038 755731000516 Arginine/lysine/ornithine decarboxylases [Amino acid transport and metabolism]; Region: LdcC; COG1982 755731000517 Ornithine decarboxylase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD corresponds to ornithine decarboxylase (ODC), arginine decarboxylase (ADC) and lysine...; Region: Orn_deC_like; cd00615 755731000518 homodimer interface [polypeptide binding]; other site 755731000519 pyridoxal 5'-phosphate binding site [chemical binding]; other site 755731000520 catalytic residue [active] 755731000521 Orn/Lys/Arg decarboxylase, C-terminal domain; Region: OKR_DC_1_C; pfam03711 755731000522 thymidylate kinase; Validated; Region: tmk; PRK00698 755731000523 Thymidine monophosphate kinase (TMPK), also known as thymidylate kinase, catalyzes the phosphorylation of thymidine monophosphate (TMP) to thymidine diphosphate (TDP) utilizing ATP as its preferred phophoryl donor. TMPK represents the rate-limiting step...; Region: TMPK; cd01672 755731000524 TMP-binding site; other site 755731000525 ATP-binding site [chemical binding]; other site 755731000526 Protein of unknown function (DUF970); Region: DUF970; pfam06153 755731000527 Protein of unknown function (DUF327); Region: DUF327; pfam03885 755731000528 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cl17189 755731000529 DNA polymerase III, delta' subunit; Region: holB; TIGR00678 755731000530 Walker A motif; other site 755731000531 ATP binding site [chemical binding]; other site 755731000532 DNA polymerase III subunit delta'; Validated; Region: PRK08485 755731000533 Walker B motif; other site 755731000534 ATPase involved in DNA replication [DNA replication, recombination, and repair]; Region: HolB; COG0470 755731000535 arginine finger; other site 755731000536 Uncharacterized homolog of PSP1 [Function unknown]; Region: COG1774 755731000537 The HCP family of iron-sulfur proteins includes hybrid cluster protein (HCP), acetyl-CoA synthase (ACS), and carbon monoxide dehydrogenase (CODH), all of which contain [Fe4-S4] metal clusters at their active sites. These proteins have a conserved...; Region: HCP_like; cl14655 755731000538 4Fe-4S dicluster domain; Region: Fer4_7; pfam12838 755731000539 Predicted O-methyltransferase [General function prediction only]; Region: COG4123 755731000540 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 755731000541 S-adenosylmethionine binding site [chemical binding]; other site 755731000542 Predicted methyltransferases [General function prediction only]; Region: COG0313 755731000543 Ribosomal RNA small subunit methyltransferase I, also known as rRNA (cytidine-2'-O-)-methyltransferase RsmI; Region: RsmI; cd11648 755731000544 putative SAM binding site [chemical binding]; other site 755731000545 putative homodimer interface [polypeptide binding]; other site 755731000546 SpoVT / AbrB like domain; Region: SpoVT_AbrB; smart00966 755731000547 Uncharacterized membrane protein, required for spore maturation in B.subtilis. [General function prediction only]; Region: SpmA; COG2715 755731000548 Uncharacterized membrane protein [Function unknown]; Region: SpmB; COG0700 755731000549 Protein of unknown function (DUF2600); Region: DUF2600; pfam10776 755731000550 TatD like proteins; E.coli TatD is a cytoplasmic protein, shown to have magnesium dependent DNase activity; Region: TatD_DNAse; cd01310 755731000551 active site 755731000552 Domain of unknown function (DUF348); Region: DUF348; pfam03990 755731000553 Domain of unknown function (DUF348); Region: DUF348; pfam03990 755731000554 G5 domain; Region: G5; pfam07501 755731000555 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3584 755731000556 16S ribosomal RNA methyltransferase KsgA/Dim1 family protein; Reviewed; Region: ksgA; PRK00274 755731000557 Dimethyladenosine transferase (rRNA methylation) [Translation, ribosomal structure and biogenesis]; Region: KsgA; COG0030 755731000558 Hemerythrin; Region: Hemerythrin; cd12107 755731000559 Fe binding site [ion binding]; other site 755731000560 Cell division protein ZapA; Region: ZapA; pfam05164 755731000561 BPG-independent PGAM N-terminus (iPGM_N); Region: iPGM_N; cl17463 755731000562 Collagenase and related proteases [Posttranslational modification, protein turnover, chaperones]; Region: COG0826 755731000563 Peptidase family U32; Region: Peptidase_U32; pfam01136 755731000564 Collagenase; Region: DUF3656; pfam12392 755731000565 Peptidase family U32; Region: Peptidase_U32; cl03113 755731000566 Trimeric dUTP diphosphatases; Region: trimeric_dUTPase; cd07557 755731000567 trimer interface [polypeptide binding]; other site 755731000568 active site 755731000569 GTP-binding protein HflX; Region: GTP_HflX; TIGR03156 755731000570 GTP-binding GTPase N-terminal; Region: GTP-bdg_N; pfam13167 755731000571 HflX GTPase family; Region: HflX; cd01878 755731000572 G1 box; other site 755731000573 GTP/Mg2+ binding site [chemical binding]; other site 755731000574 Switch I region; other site 755731000575 G2 box; other site 755731000576 G3 box; other site 755731000577 Switch II region; other site 755731000578 G4 box; other site 755731000579 G5 box; other site 755731000580 Diadenosine hexaphosphate (Ap6A) hydrolase is a member of the Nudix hydrolase superfamily. Ap6A hydrolase specifically hydrolyzes diadenosine polyphosphates, but not ATP or diadenosine triphosphate, and it generates ATP as the product. Ap6A, the most...; Region: Ap6A_hydrolase; cd03673 755731000581 active site 755731000582 Ap6A binding site [chemical binding]; other site 755731000583 nudix motif; other site 755731000584 metal binding site [ion binding]; metal-binding site 755731000585 Uncharacterized conserved protein [Function unknown]; Region: COG1739 755731000586 Uncharacterized protein family UPF0029; Region: UPF0029; pfam01205 755731000587 Domain of unknown function (DUF1949); Region: DUF1949; pfam09186 755731000588 hypothetical protein; Validated; Region: PRK00110 755731000589 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 755731000590 Bacterial transcription activator, effector binding domain; Region: AraC_E_bind; smart00871 755731000591 GyrI-like small molecule binding domain; Region: GyrI-like; cl01368 755731000592 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 755731000593 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 755731000594 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3708 755731000595 AraC-like ligand binding domain; Region: AraC_binding; pfam02311 755731000596 SGNH_hydrolase, or GDSL_hydrolase, is a diverse family of lipases and esterases. The tertiary fold of the enzyme is substantially different from that of the alpha/beta hydrolase family and unique among all known hydrolases; its active site closely...; Region: SGNH_hydrolase; cl01053 755731000597 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 755731000598 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 755731000599 alpha-galactosidase; Region: PLN02808; cl17638 755731000600 modification target Cys-rich peptide, AC3_0185 family; Region: Cxxx_AC3_0185; TIGR04118 755731000601 CXXX repeat peptide modification system protein; Region: CXXX_rpt_assoc; TIGR04116 755731000602 radical SAM peptide maturase, CXXX-repeat target family; Region: rSAM_Cxxx_rpt; TIGR04115 755731000603 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 755731000604 FeS/SAM binding site; other site 755731000605 radical SAM additional 4Fe4S-binding SPASM domain; Region: rSAM_more_4Fe4S; TIGR04085 755731000606 CXXX repeat peptide maturase; Region: CXXX_matur; TIGR04119 755731000607 Peptidase domain in the S8 and S53 families; Region: Peptidases_S8_S53; cl10459 755731000608 active site 755731000609 catalytic residues [active] 755731000610 ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132 755731000611 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 755731000612 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 755731000613 Walker A/P-loop; other site 755731000614 ATP binding site [chemical binding]; other site 755731000615 Q-loop/lid; other site 755731000616 ABC transporter signature motif; other site 755731000617 Walker B; other site 755731000618 D-loop; other site 755731000619 H-loop/switch region; other site 755731000620 A predicted NlpC/p60-like peptidase; Region: BtrH; pfam14399 755731000621 CHASE3 domain; Region: CHASE3; pfam05227 755731000622 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 755731000623 dimerization interface [polypeptide binding]; other site 755731000624 Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer); Region: MA; smart00283 755731000625 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 755731000626 dimer interface [polypeptide binding]; other site 755731000627 putative CheW interface [polypeptide binding]; other site 755731000628 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 755731000629 Zn2+ binding site [ion binding]; other site 755731000630 Mg2+ binding site [ion binding]; other site 755731000631 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 755731000632 Zn2+ binding site [ion binding]; other site 755731000633 Mg2+ binding site [ion binding]; other site 755731000634 ABC-type Na+ transport system, ATPase component [Energy production and conversion / Inorganic ion transport and metabolism]; Region: NatA; COG4555 755731000635 ATP-binding cassette domain of the drug resistance transporter and related proteins, subfamily A; Region: ABC_DR_subfamily_A; cd03230 755731000636 Walker A/P-loop; other site 755731000637 ATP binding site [chemical binding]; other site 755731000638 Q-loop/lid; other site 755731000639 ABC transporter signature motif; other site 755731000640 Walker B; other site 755731000641 D-loop; other site 755731000642 H-loop/switch region; other site 755731000643 Predicted membrane protein [Function unknown]; Region: COG4905 755731000644 Protein of unknown function (DUF1113); Region: DUF1113; pfam06541 755731000645 Response regulator containing CheY-like receiver domain and AraC-type DNA-binding domain [Signal transduction mechanisms]; Region: COG4753 755731000646 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 755731000647 active site 755731000648 phosphorylation site [posttranslational modification] 755731000649 intermolecular recognition site; other site 755731000650 dimerization interface [polypeptide binding]; other site 755731000651 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 755731000652 CHASE3 domain; Region: CHASE3; cl05000 755731000653 HAMP domain; Region: HAMP; pfam00672 755731000654 Histidine kinase; Region: His_kinase; pfam06580 755731000655 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 755731000656 ATP binding site [chemical binding]; other site 755731000657 Mg2+ binding site [ion binding]; other site 755731000658 G-X-G motif; other site 755731000659 ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653 755731000660 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; pfam01547 755731000661 ABC-type polysaccharide transport system, permease component [Carbohydrate transport and metabolism]; Region: LplB; COG4209 755731000662 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 755731000663 dimer interface [polypeptide binding]; other site 755731000664 conserved gate region; other site 755731000665 putative PBP binding loops; other site 755731000666 ABC-ATPase subunit interface; other site 755731000667 ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395 755731000668 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 755731000669 dimer interface [polypeptide binding]; other site 755731000670 conserved gate region; other site 755731000671 putative PBP binding loops; other site 755731000672 ABC-ATPase subunit interface; other site 755731000673 Probable beta-xylosidase; Provisional; Region: PLN03080 755731000674 Glycosyl hydrolase family 3 N terminal domain; Region: Glyco_hydro_3; pfam00933 755731000675 Fibronectin type III-like domain; Region: Fn3-like; pfam14310 755731000676 N-Utilization Substance G (NusG) N-terminal (NGN) domain Superfamily; Region: NGN; cd08000 755731000677 Transcription antiterminator [Transcription]; Region: NusG; COG0250 755731000678 NusG contains an NGN domain at its N-terminus and KOW motif at its C-terminus; Region: KOW_NusG; cd06091 755731000679 heterodimer interface [polypeptide binding]; other site 755731000680 homodimer interface [polypeptide binding]; other site 755731000681 Methionyl-tRNA synthetase [Translation, ribosomal structure and biogenesis]; Region: MetG; COG0143 755731000682 nucleotidyl transferase superfamily; Region: nt_trans; cl00015 755731000683 active site 755731000684 HIGH motif; other site 755731000685 nucleotide binding site [chemical binding]; other site 755731000686 nucleotidyl transferase superfamily; Region: nt_trans; cl00015 755731000687 KMSKS motif; other site 755731000688 Anticodon-binding domain of class Ia aminoacyl tRNA synthetases and similar domains; Region: Anticodon_Ia_like; cl12020 755731000689 tRNA binding surface [nucleotide binding]; other site 755731000690 anticodon binding site; other site 755731000691 Xanthine/uracil/vitamin C permease [Nucleotide transport and metabolism]; Region: COG2252 755731000692 Acetyl xylan esterase (AXE1); Region: AXE1; pfam05448 755731000693 Prolyl oligopeptidase family; Region: Peptidase_S9; pfam00326 755731000694 hypothetical protein; Provisional; Region: PRK06851 755731000695 Virulence-associated protein E; Region: VirE; pfam05272 755731000696 NTPase; Region: NTPase_1; cl17478 755731000697 Phosphoenolpyruvate carboxykinase (PEPCK), a critical gluconeogenic enzyme, catalyzes the first committed step in the diversion of tricarboxylic acid cycle intermediates toward gluconeogenesis. It catalyzes the reversible decarboxylation and...; Region: PEPCK_GTP; cd00819 755731000698 active site 755731000699 substrate-binding site [chemical binding]; other site 755731000700 metal-binding site [ion binding] 755731000701 GTP binding site [chemical binding]; other site 755731000702 helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347 755731000703 MarR family; Region: MarR; pfam01047 755731000704 Predicted ATPase involved in chromosome partitioning [Cell division and chromosome partitioning]; Region: ArsA; COG0003 755731000705 ArsA ATPase functionas as an efflux pump located on the inner membrane of the cell. This ATP-driven oxyanion pump catalyzes the extrusion of arsenite, antimonite and arsenate. Maintenance of a low intracellular concentration of oxyanion produces...; Region: ArsA; cd02035 755731000706 P loop; other site 755731000707 Nucleotide binding site [chemical binding]; other site 755731000708 DTAP/Switch II; other site 755731000709 Switch I; other site 755731000710 Predicted ATPase involved in chromosome partitioning [Cell division and chromosome partitioning]; Region: ArsA; COG0003 755731000711 ArsA ATPase functionas as an efflux pump located on the inner membrane of the cell. This ATP-driven oxyanion pump catalyzes the extrusion of arsenite, antimonite and arsenate. Maintenance of a low intracellular concentration of oxyanion produces...; Region: ArsA; cd02035 755731000712 P loop; other site 755731000713 Nucleotide binding site [chemical binding]; other site 755731000714 DTAP/Switch II; other site 755731000715 Switch I; other site 755731000716 Alpha-crystallin domain (ACD) of alpha-crystallin-type small(s) heat shock proteins (Hsps). sHsps are small stress induced proteins with monomeric masses between 12 -43 kDa, whose common feature is the Alpha-crystallin domain (ACD). sHsps are generally...; Region: ACD_sHsps-like; cd06464 755731000717 putative dimer interface [polypeptide binding]; other site 755731000718 Type 1 glutamine amidotransferase (GATase1)-like domain; Region: GAT_1; cl00020 755731000719 Glucuronate isomerase; Region: UxaC; pfam02614 755731000720 Glucuronate isomerase [Carbohydrate transport and metabolism]; Region: UxaC; COG1904 755731000721 Highly conserved protein containing a thioredoxin domain [Posttranslational modification, protein turnover, chaperones]; Region: COG1331 755731000722 TRX domain, SSP411 protein family; members of this family are highly conserved proteins present in eukaryotes, bacteria and archaea, about 600-800 amino acids in length, which contain a TRX domain with a redox active CXXC motif. The human/rat protein; Region: SSP411; cd02955 755731000723 catalytic residues [active] 755731000724 Cytosine-C5 specific DNA methylases; Methyl transfer reactions play an important role in many aspects of biology. Cytosine-specific DNA methylases are found both in prokaryotes and eukaryotes. DNA methylation, or the covalent addition of a methyl group...; Region: Cyt_C5_DNA_methylase; cd00315 755731000725 C-5 cytosine-specific DNA methylase; Region: DNA_methylase; pfam00145 755731000726 cofactor binding site; other site 755731000727 DNA binding site [nucleotide binding] 755731000728 substrate interaction site [chemical binding]; other site 755731000729 Proteins of this family catalyze the reduction of flavin or nitrocompounds using NAD(P)H as electron donor in a obligatory two-electron transfer, utilizing FMN or FAD as cofactor. They are often found to be homodimers. Enzymes of this family are...; Region: Nitro_FMN_reductase; cl00514 755731000730 FMN binding site [chemical binding]; other site 755731000731 dimer interface [polypeptide binding]; other site 755731000732 Protein of unknown function (DUF3796); Region: DUF3796; pfam12676 755731000733 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 755731000734 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 755731000735 non-specific DNA binding site [nucleotide binding]; other site 755731000736 salt bridge; other site 755731000737 sequence-specific DNA binding site [nucleotide binding]; other site 755731000738 Membrane proteins related to metalloendopeptidases [Cell envelope biogenesis, outer membrane]; Region: NlpD; COG0739 755731000739 Peptidase family M23; Region: Peptidase_M23; pfam01551 755731000740 Helix-turn-helix domain; Region: HTH_18; pfam12833 755731000741 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 755731000742 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 755731000743 S-adenosylmethionine binding site [chemical binding]; other site 755731000744 Phosphoglycerate kinase; Region: PGK; pfam00162 755731000745 Phosphoglycerate kinase (PGK) is a monomeric enzyme which catalyzes the transfer of the high-energy phosphate group of 1,3-bisphosphoglycerate to ADP, forming ATP and 3-phosphoglycerate. This reaction represents the first of the two substrate-level...; Region: Phosphoglycerate_kinase; cd00318 755731000746 substrate binding site [chemical binding]; other site 755731000747 hinge regions; other site 755731000748 ADP binding site [chemical binding]; other site 755731000749 catalytic site [active] 755731000750 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 755731000751 non-specific DNA binding site [nucleotide binding]; other site 755731000752 salt bridge; other site 755731000753 sequence-specific DNA binding site [nucleotide binding]; other site 755731000754 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cl17189 755731000755 Predicted transcriptional regulators [Transcription]; Region: COG1725 755731000756 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 755731000757 DNA-binding site [nucleotide binding]; DNA binding site 755731000758 ABC-type multidrug transport system, ATPase component [Defense mechanisms]; Region: CcmA; COG1131 755731000759 ATP-binding cassette domain of the drug resistance transporter and related proteins, subfamily A; Region: ABC_DR_subfamily_A; cd03230 755731000760 Walker A/P-loop; other site 755731000761 ATP binding site [chemical binding]; other site 755731000762 Q-loop/lid; other site 755731000763 ABC transporter signature motif; other site 755731000764 Walker B; other site 755731000765 D-loop; other site 755731000766 H-loop/switch region; other site 755731000767 ABC-2 family transporter protein; Region: ABC2_membrane_5; pfam13346 755731000768 Ammonium Transporter Family; Region: Ammonium_transp; cl03012 755731000769 Domain of unknown function (DUF4367); Region: DUF4367; pfam14285 755731000770 DNA-directed RNA polymerase specialized sigma subunit, sigma24 homolog [Transcription]; Region: RpoE; COG1595 755731000771 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 755731000772 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 755731000773 DNA binding residues [nucleotide binding] 755731000774 Domain of unknown function (DUF4352); Region: DUF4352; pfam11611 755731000775 Beta-glucosidase-related glycosidases [Carbohydrate transport and metabolism]; Region: BglX; COG1472 755731000776 Glycosyl hydrolase family 3 N terminal domain; Region: Glyco_hydro_3; pfam00933 755731000777 Na(+)/proline cotransporter PutP and related proteins; solute binding domain; Region: SLC5sbd_PutP; cd11475 755731000778 Predicted symporter [General function prediction only]; Region: DhlC; COG4147 755731000779 Na binding site [ion binding]; other site 755731000780 Nudix hydrolase is a superfamily of enzymes found in all three kingdoms of life, and it catalyzes the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+...; Region: Nudix_Hydrolase; cd02883 755731000781 nudix motif; other site 755731000782 endoglucanase; Region: PLN02420 755731000783 Glycosyl hydrolase family 9; Region: Glyco_hydro_9; pfam00759 755731000784 Cellulose binding domain; Region: CBM_3; smart01067 755731000785 Dockerin type I repeat; Region: Dockerin_1; pfam00404 755731000786 Dienelactone hydrolase and related enzymes [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG0412 755731000787 Putative redox-active protein (C_GCAxxG_C_C); Region: C_GCAxxG_C_C; pfam09719 755731000788 heavy metal-(Cd/Co/Hg/Pb/Zn)-translocating P-type ATPase; Region: ATPase-IB2_Cd; TIGR01512 755731000789 E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122 755731000790 Heavy-metal-associated domain (HMA) is a conserved domain of approximately 30 amino acid residues found in a number of proteins that transport or detoxify heavy metals, for example, the CPx-type heavy metal ATPases and copper chaperones. HMA domain...; Region: HMA; cd00371 755731000791 metal-binding site [ion binding] 755731000792 RNA recognition motif (RRM) superfamily; Region: RRM_SF; cl17169 755731000793 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 755731000794 dimerization interface [polypeptide binding]; other site 755731000795 putative DNA binding site [nucleotide binding]; other site 755731000796 putative Zn2+ binding site [ion binding]; other site 755731000797 YabG peptidase U57; Region: Peptidase_U57; cl05250 755731000798 DNA polymerase III subunits gamma and tau; Validated; Region: PRK05563 755731000799 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 755731000800 Walker A motif; other site 755731000801 ATP binding site [chemical binding]; other site 755731000802 Walker B motif; other site 755731000803 arginine finger; other site 755731000804 DNA polymerase III subunits gamma and tau domain III; Region: DNA_pol3_gamma3; pfam12169 755731000805 hypothetical protein; Validated; Region: PRK00153 755731000806 recombination protein RecR; Reviewed; Region: recR; PRK00076 755731000807 RecR protein; Region: RecR; pfam02132 755731000808 TOPRIM_recR: topoisomerase-primase (TOPRIM) nucleotidyl transferase/hydrolase domain of the type found in Escherichia coli RecR. RecR participates in the RecFOR pathway of homologous recombinational repair in prokaryotes. This pathway provides a...; Region: TOPRIM_recR; cd01025 755731000809 putative active site [active] 755731000810 putative metal-binding site [ion binding]; other site 755731000811 tetramer interface [polypeptide binding]; other site 755731000812 Four helix bundle sensory module for signal transduction; Region: 4HB_MCP_1; pfam12729 755731000813 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 755731000814 dimerization interface [polypeptide binding]; other site 755731000815 Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer); Region: MA; smart00283 755731000816 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 755731000817 dimer interface [polypeptide binding]; other site 755731000818 putative CheW interface [polypeptide binding]; other site 755731000819 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 755731000820 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 755731000821 active site 755731000822 phosphorylation site [posttranslational modification] 755731000823 intermolecular recognition site; other site 755731000824 dimerization interface [polypeptide binding]; other site 755731000825 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 755731000826 DNA binding site [nucleotide binding] 755731000827 HAMP domain; Region: HAMP; pfam00672 755731000828 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 755731000829 dimer interface [polypeptide binding]; other site 755731000830 phosphorylation site [posttranslational modification] 755731000831 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 755731000832 ATP binding site [chemical binding]; other site 755731000833 Mg2+ binding site [ion binding]; other site 755731000834 G-X-G motif; other site 755731000835 putative manganese-dependent inorganic pyrophosphatase; Provisional; Region: PRK14869 755731000836 The CBS domain, named after human CBS, is a small domain originally identified in cystathionine beta-synthase and is subsequently found in a wide range of different proteins. CBS domains usually occur in tandem repeats. They associate to form a so-called...; Region: CBS_pair; cl15354 755731000837 DRTGG domain; Region: DRTGG; pfam07085 755731000838 CBS domain; Region: CBS; pfam00571 755731000839 DHH family; Region: DHH; pfam01368 755731000840 DHHA2 domain; Region: DHHA2; pfam02833 755731000841 Polyphosphate(polyP) polymerase domain of yeast vacuolar transport chaperone (VTC) proteins VTC-2, -3 and- 4, and similar proteins; Region: PolyPPase_VTC_like; cd07750 755731000842 putative metal binding residues [ion binding]; other site 755731000843 signature motif; other site 755731000844 dimer interface [polypeptide binding]; other site 755731000845 active site 755731000846 polyP binding site; other site 755731000847 substrate binding site [chemical binding]; other site 755731000848 acceptor-phosphate pocket; other site 755731000849 Uncharacterized membrane protein [Function unknown]; Region: SapB; COG1285 755731000850 CotH protein; Region: CotH; pfam08757 755731000851 Hemolysins and related proteins containing CBS domains [General function prediction only]; Region: TlyC; COG1253 755731000852 Domain of unknown function DUF21; Region: DUF21; pfam01595 755731000853 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains associated with the CorC_HlyC domain. CorC_HlyC is a transporter associated domain. This small domain is found in Na+/H+ antiporters, in proteins involved in...; Region: CBS_pair_CorC_HlyC_assoc; cd04590 755731000854 Transporter associated domain; Region: CorC_HlyC; pfam03471 755731000855 Protein of unknown function (DUF2089); Region: DUF2089; pfam09862 755731000856 PucR C-terminal helix-turn-helix domain; Region: HTH_30; pfam13556 755731000857 Domain of unknown function (DUF4098); Region: DUF4098; pfam13345 755731000858 peptide chain release factor 1; Validated; Region: prfA; PRK00591 755731000859 This domain is found in peptide chain release factors; Region: PCRF; smart00937 755731000860 RF-1 domain; Region: RF-1; pfam00472 755731000861 Predicted divalent heavy-metal cations transporter [Inorganic ion transport and metabolism]; Region: COG0428 755731000862 Putative translation factor (SUA5) [Translation, ribosomal structure and biogenesis]; Region: SUA5; COG0009 755731000863 Putative GTP-binding controlling metal-binding; Region: SUA5; pfam03481 755731000864 Protein-tyrosine-phosphatase [Signal transduction mechanisms]; Region: Wzb; COG0394 755731000865 Low molecular weight phosphatase family; Region: LMWPc; cd00115 755731000866 active site 755731000867 ribose-5-phosphate isomerase B; Provisional; Region: PRK05571 755731000868 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 755731000869 active site 755731000870 Deoxycytidylate deaminase domain. Deoxycytidylate deaminase catalyzes the deamination of dCMP to dUMP, providing the nucleotide substrate for thymidylate synthase. The enzyme binds Zn++, which is required for catalytic activity. The activity of the...; Region: deoxycytidylate_deaminase; cd01286 755731000871 catalytic motif [active] 755731000872 Zn binding site [ion binding]; other site 755731000873 UDP-N-acetylmuramyl pentapeptide phosphotransferase/UDP-N- acetylglucosamine-1-phosphate transferase [Cell envelope biogenesis, outer membrane]; Region: Rfe; COG0472 755731000874 This subfamily contains Escherichia coli WecA, Bacillus subtilis TagO and related proteins. WecA is an UDP-N-acetylglucosamine (GlcNAc):undecaprenyl-phosphate (Und-P) GlcNAc-1-phosphate transferase that catalyzes the formation of a phosphodiester bond...; Region: GT_WecA_like; cd06853 755731000875 Mg++ binding site [ion binding]; other site 755731000876 putative catalytic motif [active] 755731000877 substrate binding site [chemical binding]; other site 755731000878 UDP-N-acetylglucosamine 2-epimerase [Cell envelope biogenesis, outer membrane]; Region: WecB; COG0381 755731000879 Bacterial members of the UDP-N-Acetylglucosamine (GlcNAc) 2-Epimerase family are known to catalyze the reversible interconversion of UDP-GlcNAc and UDP-N-acetylmannosamine (UDP-ManNAc). The enzyme serves to produce an activated form of ManNAc residues; Region: GT1_UDP-GlcNAc_2-Epimerase; cd03786 755731000880 active site 755731000881 homodimer interface [polypeptide binding]; other site 755731000882 Membrane MotB of proton-channel complex MotA/MotB; Region: MotB_plug; pfam13677 755731000883 Flagellar motor protein [Cell motility and secretion]; Region: MotB; COG1360 755731000884 Peptidoglycan binding domains similar to the C-terminal domain of outer-membrane protein OmpA; Region: OmpA_C-like; cd07185 755731000885 ligand binding site [chemical binding]; other site 755731000886 MotA/TolQ/ExbB proton channel family; Region: MotA_ExbB; cl00568 755731000887 Flagellar motor component [Cell motility and secretion]; Region: MotA; COG1291 755731000888 F0F1-type ATP synthase, subunit a [Energy production and conversion]; Region: AtpB; COG0356 755731000889 F0F1 ATP synthase subunit A; Validated; Region: PRK05815 755731000890 F0F1 ATP synthase subunit C; Provisional; Region: PRK13469 755731000891 F0F1 ATP synthase subunit B; Validated; Region: PRK05759 755731000892 F0F1-type ATP synthase, subunit b [Energy production and conversion]; Region: AtpF; COG0711 755731000893 ATP synthase delta (OSCP) subunit; Region: OSCP; pfam00213 755731000894 F0F1-type ATP synthase, delta subunit (mitochondrial oligomycin sensitivity protein) [Energy production and conversion]; Region: AtpH; cl17210 755731000895 F0F1 ATP synthase subunit alpha; Validated; Region: PRK09281 755731000896 ATP synthase alpha/beta family, beta-barrel domain; Region: ATP-synt_ab_N; pfam02874 755731000897 F1 ATP synthase alpha, central domain. The F-ATPase is found in bacterial plasma membranes, mitochondrial inner membranes and in chloroplast thylakoid membranes. It has also been found in the archaea Methanosarcina barkeri. It uses a proton gradient to...; Region: F1_ATPase_alpha; cd01132 755731000898 beta subunit interaction interface [polypeptide binding]; other site 755731000899 Walker A motif; other site 755731000900 ATP binding site [chemical binding]; other site 755731000901 Walker B motif; other site 755731000902 ATP synthase alpha/beta chain, C terminal domain; Region: ATP-synt_ab_C; pfam00306 755731000903 mitochondrial ATP synthase gamma subunit; Region: F1-ATPase_gamma; cd12151 755731000904 core domain interface [polypeptide binding]; other site 755731000905 delta subunit interface [polypeptide binding]; other site 755731000906 epsilon subunit interface [polypeptide binding]; other site 755731000907 F0F1 ATP synthase subunit beta; Validated; Region: PRK09280 755731000908 ATP synthase alpha/beta family, beta-barrel domain; Region: ATP-synt_ab_N; pfam02874 755731000909 F1 ATP synthase beta subunit, nucleotide-binding domain. The F-ATPase is found in bacterial plasma membranes, mitochondrial inner membranes and in chloroplast thylakoid membranes. It has also been found in the archaea Methanosarcina barkeri. It uses a...; Region: F1-ATPase_beta; cd01133 755731000910 alpha subunit interaction interface [polypeptide binding]; other site 755731000911 Walker A motif; other site 755731000912 ATP binding site [chemical binding]; other site 755731000913 Walker B motif; other site 755731000914 inhibitor binding site; inhibition site 755731000915 ATP synthase alpha/beta chain, C terminal domain; Region: ATP-synt_ab_C; pfam00306 755731000916 F0F1 ATP synthase subunit epsilon; Validated; Region: atpC; PRK00571 755731000917 mitochondrial ATP synthase delta subunit; Region: F1-ATPase_delta; cd12152 755731000918 gamma subunit interface [polypeptide binding]; other site 755731000919 epsilon subunit interface [polypeptide binding]; other site 755731000920 LBP interface [polypeptide binding]; other site 755731000921 Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all...; Region: FN3; cd00063 755731000922 Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all...; Region: FN3; cd00063 755731000923 Interdomain contacts; other site 755731000924 Cytokine receptor motif; other site 755731000925 Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all...; Region: FN3; cd00063 755731000926 Interdomain contacts; other site 755731000927 Cytokine receptor motif; other site 755731000928 Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all...; Region: FN3; cd00063 755731000929 Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all...; Region: FN3; cd00063 755731000930 Interdomain contacts; other site 755731000931 Cytokine receptor motif; other site 755731000932 S-layer homology domain; Region: SLH; pfam00395 755731000933 S-layer homology domain; Region: SLH; pfam00395 755731000934 S-layer homology domain; Region: SLH; pfam00395 755731000935 Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all...; Region: FN3; cd00063 755731000936 Interdomain contacts; other site 755731000937 Cytokine receptor motif; other site 755731000938 Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all...; Region: FN3; cd00063 755731000939 Interdomain contacts; other site 755731000940 Cytokine receptor motif; other site 755731000941 S-layer homology domain; Region: SLH; pfam00395 755731000942 S-layer homology domain; Region: SLH; pfam00395 755731000943 Protein of unknown function (DUF1779); Region: DUF1779; pfam08680 755731000944 UDP-N-acetylglucosamine 1-carboxyvinyltransferase; Region: murA; TIGR01072 755731000945 UDP-N-acetylglucosamine enolpyruvyl transferase catalyzes enolpyruvyl transfer as part of the first step in the biosynthesis of peptidoglycan, a component of the bacterial cell wall. The reaction is phosphoenolpyruvate + UDP-N-acetyl-D-glucosamine =...; Region: UdpNAET; cd01555 755731000946 hinge; other site 755731000947 active site 755731000948 stage II sporulation protein D; Region: spore_II_D; TIGR02870 755731000949 Stage II sporulation protein; Region: SpoIID; pfam08486 755731000950 Membrane proteins related to metalloendopeptidases [Cell envelope biogenesis, outer membrane]; Region: NlpD; COG0739 755731000951 Peptidase family M23; Region: Peptidase_M23; pfam01551 755731000952 D-alanyl-alanine synthetase A; Reviewed; Region: ddl; PRK01966 755731000953 D-ala D-ala ligase N-terminus; Region: Dala_Dala_lig_N; pfam01820 755731000954 D-ala D-ala ligase C-terminus; Region: Dala_Dala_lig_C; pfam07478 755731000955 Domain of unknown function (DUF1934); Region: DUF1934; pfam09148 755731000956 arginyl-tRNA synthetase; Reviewed; Region: argS; PRK01611 755731000957 Arginyl tRNA synthetase N terminal domain; Region: Arg_tRNA_synt_N; pfam03485 755731000958 catalytic core domain of arginyl-tRNA synthetases; Region: ArgRS_core; cd00671 755731000959 active site 755731000960 HIGH motif; other site 755731000961 KMSK motif region; other site 755731000962 Anticodon-binding domain of arginyl tRNA synthetases; Region: Anticodon_Ia_Arg; cd07956 755731000963 tRNA binding surface [nucleotide binding]; other site 755731000964 anticodon binding site; other site 755731000965 Dockerin type I repeat; Region: Dockerin_1; pfam00404 755731000966 Predicted xylanase/chitin deacetylase [Carbohydrate transport and metabolism]; Region: CDA1; COG0726 755731000967 Catalytic NodB homology domain of the carbohydrate esterase 4 superfamily; Region: CE4_SF; cl15692 755731000968 Methyl-accepting chemotaxis protein [Cell motility and secretion / Signal transduction mechanisms]; Region: Tar; COG0840 755731000969 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 755731000970 dimer interface [polypeptide binding]; other site 755731000971 putative CheW interface [polypeptide binding]; other site 755731000972 S-layer homology domain; Region: SLH; pfam00395 755731000973 S-layer homology domain; Region: SLH; pfam00395 755731000974 C-terminal processing peptidase family S41; Region: Peptidase_S41; cl02526 755731000975 C-terminal peptidase (prc); Region: prc; TIGR00225 755731000976 PDZ domain of C-terminal processing-, tail-specific-, and tricorn proteases, which function in posttranslational protein processing, maturation, and disassembly or degradation, in Bacteria, Archaea, and plant chloroplasts. May be responsible for...; Region: PDZ_CTP_protease; cd00988 755731000977 protein binding site [polypeptide binding]; other site 755731000978 C-terminal processing peptidase; serine protease family S41; Region: Peptidase_S41_CPP; cd07560 755731000979 Catalytic dyad [active] 755731000980 Putative peptidoglycan binding domain; Region: PG_binding_1; pfam01471 755731000981 CTP synthetase; Validated; Region: pyrG; PRK05380 755731000982 CTP synthetase (CTPs) is a two-domain protein, which consists of an N-terminal synthetase domain and C-terminal glutaminase domain. The enzymes hydrolyze the amide bond of glutamine to ammonia and glutamate at the glutaminase domains and transfer nascent...; Region: CTGs; cd03113 755731000983 Catalytic site [active] 755731000984 active site 755731000985 UTP binding site [chemical binding]; other site 755731000986 Type 1 glutamine amidotransferase (GATase1) domain found in Cytidine Triphosphate Synthetase; Region: GATase1_CTP_Synthase; cd01746 755731000987 active site 755731000988 putative oxyanion hole; other site 755731000989 catalytic triad [active] 755731000990 Stage II sporulation protein R (spore_II_R); Region: Spore_II_R; pfam09551 755731000991 putative Mg(2+) transport ATPase; Provisional; Region: PRK09977 755731000992 MgtC family; Region: MgtC; pfam02308 755731000993 Cation transport ATPase [Inorganic ion transport and metabolism]; Region: MgtA; COG0474 755731000994 Cation transporter/ATPase, N-terminus; Region: Cation_ATPase_N; pfam00690 755731000995 E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122 755731000996 Putative hydrolase of sodium-potassium ATPase alpha subunit; Region: Hydrolase_like2; pfam13246 755731000997 haloacid dehalogenase-like hydrolase; Region: HAD; cl17202 755731000998 Cation transporting ATPase, C-terminus; Region: Cation_ATPase_C; pfam00689 755731000999 gliding motility-associated ABC transporter ATP-binding subunit GldA; Region: GldA_ABC_ATP; TIGR03522 755731001000 ATP-binding cassette domain of the drug resistance transporter and related proteins, subfamily A; Region: ABC_DR_subfamily_A; cd03230 755731001001 Walker A/P-loop; other site 755731001002 ATP binding site [chemical binding]; other site 755731001003 Q-loop/lid; other site 755731001004 ABC transporter signature motif; other site 755731001005 Walker B; other site 755731001006 D-loop; other site 755731001007 H-loop/switch region; other site 755731001008 gliding motility-associated ABC transporter permease protein GldF; Region: ABC_perm_GldF; TIGR03518 755731001009 ABC-type uncharacterized transport system; Region: ABC_transp_aux; pfam09822 755731001010 Domain of unknown function (DUF4340); Region: DUF4340; pfam14238 755731001011 Domain of unknown function (DUF4340); Region: DUF4340; pfam14238 755731001012 Uncharacterized membrane protein [Function unknown]; Region: COG3949 755731001013 PQQ-like domain; Region: PQQ_2; pfam13360 755731001014 Colicin V production protein; Region: Colicin_V; pfam02674 755731001015 Colicin V production protein; Region: Colicin_V; cl00567 755731001016 dihydroxy-acid dehydratase; Provisional; Region: PRK00911 755731001017 acetolactate synthase 3 catalytic subunit; Reviewed; Region: PRK06048 755731001018 Pyrimidine (PYR) binding domain of POX and related proteins; Region: TPP_PYR_POX_like; cd07035 755731001019 PYR/PP interface [polypeptide binding]; other site 755731001020 dimer interface [polypeptide binding]; other site 755731001021 TPP binding site [chemical binding]; other site 755731001022 Thiamine pyrophosphate enzyme, central domain; Region: TPP_enzyme_M; pfam00205 755731001023 Thiamine pyrophosphate (TPP) family, Acetohydroxyacid synthase (AHAS) subfamily, TPP-binding module; composed of proteins similar to the large catalytic subunit of AHAS. AHAS catalyzes the condensation of two molecules of pyruvate to give the...; Region: TPP_AHAS; cd02015 755731001024 TPP-binding site [chemical binding]; other site 755731001025 dimer interface [polypeptide binding]; other site 755731001026 Superfamily II DNA and RNA helicases [DNA replication, recombination, and repair / Transcription / Translation, ribosomal structure and biogenesis]; Region: SrmB; COG0513 755731001027 DEAD-box helicases. A diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker B motif; Region: DEADc; cd00268 755731001028 ATP binding site [chemical binding]; other site 755731001029 Mg++ binding site [ion binding]; other site 755731001030 motif III; other site 755731001031 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 755731001032 nucleotide binding region [chemical binding]; other site 755731001033 ATP-binding site [chemical binding]; other site 755731001034 50S ribosomal protein L33; Validated; Region: rpmG; PRK00504 755731001035 SecE/Sec61-gamma subunits of protein translocation complex; Region: SecE; pfam00584 755731001036 transcription antitermination protein NusG; Validated; Region: nusG; PRK05609 755731001037 Bacterial N-Utilization Substance G (NusG) N-terminal (NGN) domain, subgroup 1; Region: NGN_Bact_1; cd09891 755731001038 putative homodimer interface [polypeptide binding]; other site 755731001039 NusG contains an NGN domain at its N-terminus and KOW motif at its C-terminus; Region: KOW_NusG; cd06091 755731001040 heterodimer interface [polypeptide binding]; other site 755731001041 homodimer interface [polypeptide binding]; other site 755731001042 50S ribosomal protein L11; Validated; Region: rplK; PRK00140 755731001043 Ribosomal protein L11. Ribosomal protein L11, together with proteins L10 and L7/L12, and 23S rRNA, form the L7/L12 stalk on the surface of the large subunit of the ribosome. The homologous eukaryotic cytoplasmic protein is also called 60S ribosomal...; Region: Ribosomal_L11; cd00349 755731001044 23S rRNA interface [nucleotide binding]; other site 755731001045 L7/L12 interface [polypeptide binding]; other site 755731001046 putative thiostrepton binding site; other site 755731001047 L25 interface [polypeptide binding]; other site 755731001048 Ribosomal protein L1. The L1 protein, located near the E-site of the ribosome, forms part of the L1 stalk along with 23S rRNA. In bacteria and archaea, L1 functions both as a ribosomal protein that binds rRNA, and as a translation repressor that binds...; Region: Ribosomal_L1; cd00403 755731001049 mRNA/rRNA interface [nucleotide binding]; other site 755731001050 Ribosomal protein L10 family, L10 subfamily; composed of bacterial 50S ribosomal protein and eukaryotic mitochondrial 39S ribosomal protein, L10. L10 occupies the L7/L12 stalk of the ribosome. The N-terminal domain (NTD) of L10 interacts with L11 protein...; Region: Ribosomal_L10; cd05797 755731001051 23S rRNA interface [nucleotide binding]; other site 755731001052 Interface with L7/L12 ribosomal proteins [polypeptide binding]; other site 755731001053 Ribosomal protein L7/L12. Ribosomal protein L7/L12 refers to the large ribosomal subunit proteins L7 and L12, which are identical except that L7 is acetylated at the N terminus. It is a component of the L7/L12 stalk, which is located at the surface of...; Region: Ribosomal_L7_L12; cd00387 755731001054 core dimer interface [polypeptide binding]; other site 755731001055 peripheral dimer interface [polypeptide binding]; other site 755731001056 L10 interface [polypeptide binding]; other site 755731001057 L11 interface [polypeptide binding]; other site 755731001058 putative EF-Tu interaction site [polypeptide binding]; other site 755731001059 putative EF-G interaction site [polypeptide binding]; other site 755731001060 RNA polymerase beta subunit. RNA polymerases catalyse the DNA dependent polymerization of RNA. Prokaryotes contain a single RNA polymerase compared to three in eukaryotes (not including mitochondrial. and chloroplast polymerases). Each RNA polymerase...; Region: RNA_pol_B_RPB2; cl17585 755731001061 RNA polymerase Rpb2, domain 2; Region: RNA_pol_Rpb2_2; pfam04561 755731001062 DNA-directed RNA polymerase subunit beta; Reviewed; Region: rpoB; PRK00405 755731001063 RNA polymerase beta subunit. RNA polymerases catalyse the DNA dependent polymerization of RNA. Prokaryotes contain a single RNA polymerase compared to three in eukaryotes (not including mitochondrial. and chloroplast polymerases). Each RNA polymerase...; Region: RNA_pol_B_RPB2; cd00653 755731001064 RPB1 interaction site [polypeptide binding]; other site 755731001065 RPB10 interaction site [polypeptide binding]; other site 755731001066 RPB11 interaction site [polypeptide binding]; other site 755731001067 RPB3 interaction site [polypeptide binding]; other site 755731001068 RPB12 interaction site [polypeptide binding]; other site 755731001069 DNA-directed RNA polymerase subunit beta'; Provisional; Region: PRK00566 755731001070 RNA polymerase Rpb1, domain 1; Region: RNA_pol_Rpb1_1; pfam04997 755731001071 RNA polymerase I subunit A N-terminus; Region: RPOLA_N; smart00663 755731001072 RNA polymerase Rpb1, domain 3; Region: RNA_pol_Rpb1_3; pfam04983 755731001073 RNA polymerase Rpb1, domain 4; Region: RNA_pol_Rpb1_4; pfam05000 755731001074 Largest subunit (beta') of Bacterial DNA-dependent RNA polymerase (RNAP), C-terminal domain; Region: RNAP_beta'_C; cd02655 755731001075 Rpb1 (beta') - Rpb6 (omega) interaction site [polypeptide binding]; other site 755731001076 Rpb1 (beta') - Rpb2 (beta) interaction site [polypeptide binding]; other site 755731001077 G-loop; other site 755731001078 DNA binding site [nucleotide binding] 755731001079 putative ribosomal protein L7Ae-like; Provisional; Region: PRK13602 755731001080 S12-like family, 30S ribosomal protein S12 subfamily; S12 is located at the interface of the large and small ribosomal subunits of prokaryotes, chloroplasts and mitochondria, where it plays an important role in both tRNA and ribosomal subunit...; Region: Ribosomal_S12; cd03368 755731001081 S17 interaction site [polypeptide binding]; other site 755731001082 S8 interaction site; other site 755731001083 16S rRNA interaction site [nucleotide binding]; other site 755731001084 streptomycin interaction site [chemical binding]; other site 755731001085 23S rRNA interaction site [nucleotide binding]; other site 755731001086 aminoacyl-tRNA interaction site (A-site) [nucleotide binding]; other site 755731001087 30S ribosomal protein S7; Validated; Region: PRK05302 755731001088 elongation factor G; Reviewed; Region: PRK00007 755731001089 Elongation factor G (EF-G) family involved in both the elongation and ribosome recycling phases of protein synthesis; Region: EF-G; cd01886 755731001090 G1 box; other site 755731001091 putative GEF interaction site [polypeptide binding]; other site 755731001092 GTP/Mg2+ binding site [chemical binding]; other site 755731001093 Switch I region; other site 755731001094 G2 box; other site 755731001095 G3 box; other site 755731001096 Switch II region; other site 755731001097 G4 box; other site 755731001098 G5 box; other site 755731001099 EFG_mtEFG_II: this subfamily represents the domain II of elongation factor G (EF-G) in bacteria and, the C-terminus of mitochondrial Elongation factor G1 (mtEFG1) and G2 (mtEFG2)_like proteins found in eukaryotes. During the process of peptide synthesis...; Region: EFG_mtEFG_II; cd04088 755731001100 EFG_mtEFG1_IV: domains similar to domain IV of the bacterial translational elongation factor (EF) EF-G. Included in this group is a domain of mitochondrial Elongation factor G1 (mtEFG1) proteins homologous to domain IV of EF-G. Eukaryotic cells harbor 2...; Region: EFG_mtEFG1_IV; cd01434 755731001101 EFG_mtEFG_C: domains similar to the C-terminal domain of the bacterial translational elongation factor (EF) EF-G. Included in this group is the C-terminus of mitochondrial Elongation factor G1 (mtEFG1) and G2 (mtEFG2) proteins. Eukaryotic cells harbor 2...; Region: EFG_mtEFG_C; cd03713 755731001102 elongation factor Tu; Reviewed; Region: PRK00049 755731001103 Elongation Factor Tu (EF-Tu) GTP-binding proteins; Region: EF_Tu; cd01884 755731001104 G1 box; other site 755731001105 GEF interaction site [polypeptide binding]; other site 755731001106 GTP/Mg2+ binding site [chemical binding]; other site 755731001107 Switch I region; other site 755731001108 G2 box; other site 755731001109 G3 box; other site 755731001110 Switch II region; other site 755731001111 G4 box; other site 755731001112 G5 box; other site 755731001113 EFTU_II: Elongation factor Tu domain II. Elongation factors Tu (EF-Tu) are three-domain GTPases with an essential function in the elongation phase of mRNA translation. The GTPase center of EF-Tu is in the N-terminal domain (domain I), also known as the...; Region: EFTU_II; cd03697 755731001114 Domain III of elongation factor (EF) Tu. Ef-Tu consists of three structural domains, designated I, II and III. Domain III adopts a beta barrel structure. Domain III is involved in binding to both charged tRNA and binding to elongation factor Ts (EF-Ts); Region: EFTU_III; cd03707 755731001115 Antibiotic Binding Site [chemical binding]; other site 755731001116 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 755731001117 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 755731001118 dimerization interface [polypeptide binding]; other site 755731001119 Histidine kinase; Region: His_kinase; pfam06580 755731001120 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 755731001121 ATP binding site [chemical binding]; other site 755731001122 Mg2+ binding site [ion binding]; other site 755731001123 G-X-G motif; other site 755731001124 Response regulator receiver domain; Region: Response_reg; pfam00072 755731001125 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 755731001126 active site 755731001127 phosphorylation site [posttranslational modification] 755731001128 intermolecular recognition site; other site 755731001129 dimerization interface [polypeptide binding]; other site 755731001130 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 755731001131 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 755731001132 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 755731001133 ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653 755731001134 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; pfam01547 755731001135 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 755731001136 dimer interface [polypeptide binding]; other site 755731001137 conserved gate region; other site 755731001138 putative PBP binding loops; other site 755731001139 ABC-ATPase subunit interface; other site 755731001140 ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395 755731001141 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 755731001142 dimer interface [polypeptide binding]; other site 755731001143 conserved gate region; other site 755731001144 putative PBP binding loops; other site 755731001145 ABC-ATPase subunit interface; other site 755731001146 Type 1 glutamine amidotransferase (GATase1)-like domain; Region: GAT_1; cl00020 755731001147 Protein of unknown function (DUF1498); Region: DUF1498; cl17840 755731001148 metallo-beta-lactamase/flavodoxin domain-containing protein; Provisional; Region: PRK11921 755731001149 Metallo-beta-lactamase superfamily; Region: Lactamase_B; smart00849 755731001150 Flavodoxin-like fold; Region: Flavodoxin_2; cl00438 755731001151 NifU homolog involved in Fe-S cluster formation [Energy production and conversion]; Region: IscU; COG0822 755731001152 Iron-sulfur cluster scaffold-like proteins; Region: IscU_like; cl00528 755731001153 GGGtGRT protein; Region: GGGtGRT; pfam14057 755731001154 Firmicute transcriptional repressor of class III stress genes (CtsR); Region: CtsR; pfam05848 755731001155 Modulator of heat shock repressor CtsR, McsA [Signal transduction mechanisms]; Region: COG3880 755731001156 Phosphagen (guanidino) kinases; Region: phosphagen_kinases; cl02823 755731001157 ATP:guanido phosphotransferase; Provisional; Region: PRK01059 755731001158 Phosphagen (guanidino) kinases found in bacteria; Region: bacterial_phosphagen_kinase; cd07930 755731001159 ADP binding site [chemical binding]; other site 755731001160 phosphagen binding site; other site 755731001161 substrate specificity loop; other site 755731001162 ATP-binding subunits of Clp protease and DnaK/DnaJ chaperones [Posttranslational modification, protein turnover, chaperones]; Region: clpA; COG0542 755731001163 Clp amino terminal domain; Region: Clp_N; pfam02861 755731001164 Clp amino terminal domain; Region: Clp_N; pfam02861 755731001165 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 755731001166 Walker A motif; other site 755731001167 ATP binding site [chemical binding]; other site 755731001168 Walker B motif; other site 755731001169 arginine finger; other site 755731001170 UvrB/uvrC motif; Region: UVR; pfam02151 755731001171 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 755731001172 Walker A motif; other site 755731001173 ATP binding site [chemical binding]; other site 755731001174 Walker B motif; other site 755731001175 C-terminal, D2-small domain, of ClpB protein; Region: ClpB_D2-small; pfam10431 755731001176 Cys-rich peptide radical SAM maturase CcpM; Region: rSAM_ocin_clost; TIGR04068 755731001177 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 755731001178 FeS/SAM binding site; other site 755731001179 peptide maturation system protein, TIGR04066 family; Region: nat_prod_clost 755731001180 Glycosyltransferase like family 2; Region: Glyco_tranf_2_3; pfam13641 755731001181 EpsO protein participates in the methanolan synthesis; Region: EpsO_like; cd06438 755731001182 DXD motif; other site 755731001183 oligosaccharide amylase; Region: oligosac_amyl; TIGR01577 755731001184 Glycosyl hydrolases family 15; Region: Glyco_hydro_15; pfam00723 755731001185 DNA repair protein RadA; Provisional; Region: PRK11823 755731001186 RecA-like NTPases. This family includes the NTP binding domain of F1 and V1 H+ATPases, DnaB and related helicases as well as bacterial RecA and related eukaryotic and archaeal recombinases. This group also includes bacterial conjugation proteins and...; Region: RecA-like_NTPases; cl17233 755731001187 Walker A motif; other site 755731001188 ATP binding site [chemical binding]; other site 755731001189 Walker B motif; other site 755731001190 DNA integrity scanning protein DisA; Provisional; Region: PRK13482 755731001191 DisA bacterial checkpoint controller nucleotide-binding; Region: DisA_N; pfam02457 755731001192 DisA bacterial checkpoint controller linker region; Region: DisA-linker; pfam10635 755731001193 Helix-hairpin-helix motif; Region: HHH; pfam00633 755731001194 Nucleoside Triphosphate Pyrophosphohydrolase (EC 3.6.1.8) MazG-like domain superfamily; Region: NTP-PPase; cl16941 755731001195 Transcriptional regulators, similar to M. xanthus CarD [Transcription]; Region: COG1329 755731001196 Integral membrane protein (PIN domain superfamily) [General function prediction only]; Region: COG4956 755731001197 PIN domain of Thermus Thermophilus Hb8, uncharacterized Bacillus subtilis YacL, and other bacterial homologs; Region: PIN_YacL; cd09877 755731001198 putative active site [active] 755731001199 CDP-ME synthetase is involved in mevalonate-independent isoprenoid production; Region: CDP-ME_synthetase; cd02516 755731001200 substrate binding site; other site 755731001201 dimer interface; other site 755731001202 ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132 755731001203 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 755731001204 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 755731001205 Walker A/P-loop; other site 755731001206 ATP binding site [chemical binding]; other site 755731001207 Q-loop/lid; other site 755731001208 ABC transporter signature motif; other site 755731001209 Walker B; other site 755731001210 D-loop; other site 755731001211 H-loop/switch region; other site 755731001212 MECDP_synthase (2-C-methyl-D-erythritol-2,4-cyclodiphosphate synthase), encoded by the ispF gene, catalyzes the formation of 2-C-methyl-D-erythritol 2,4-cyclodiphosphate (MEC) in the non-mevalonate deoxyxylulose (DOXP) pathway for isoprenoid biosynthesis; Region: MECDP_synthase; cd00554 755731001213 homotrimer interaction site [polypeptide binding]; other site 755731001214 zinc binding site [ion binding]; other site 755731001215 CDP-binding sites; other site 755731001216 prolyl-tRNA synthetase; Provisional; Region: PRK08661 755731001217 Prolyl-tRNA synthetase (ProRS) class II core catalytic domain. ProRS is a homodimer. It is responsible for the attachment of proline to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for ATP-dependent...; Region: ProRS_core_arch_euk; cd00778 755731001218 dimer interface [polypeptide binding]; other site 755731001219 motif 1; other site 755731001220 active site 755731001221 motif 2; other site 755731001222 motif 3; other site 755731001223 ProRS Prolyl-anticodon binding domain, long version found predominantly in eukaryotes and archaea. ProRS belongs to class II aminoacyl-tRNA synthetases (aaRS). This alignment contains the anticodon binding domain, which is responsible for specificity in...; Region: ProRS_anticodon_zinc; cd00862 755731001224 anticodon binding site; other site 755731001225 zinc-binding site [ion binding]; other site 755731001226 Bacterial SH3 domain; Region: SH3_3; pfam08239 755731001227 Uncharacterized protein with SCP/PR1 domains [Function unknown]; Region: COG2340 755731001228 SCP_bacterial: SCP-like extracellular protein domain, as found in bacteria and archaea. The wider family of SCP containing proteins includes plant pathogenesis-related protein 1 (PR-1), CRISPs, mammalian cysteine-rich secretory proteins, and allergen 5...; Region: SCP_bacterial; cd05379 755731001229 Pseudouridylate synthases, 23S RNA-specific [Translation, ribosomal structure and biogenesis]; Region: RluA; COG0564 755731001230 Pseudouridine synthase, RsuA/RluD family; Region: PseudoU_synth_RluCD_like; cd02869 755731001231 active site 755731001232 Nucleoside-diphosphate-sugar pyrophosphorylase involved in lipopolysaccharide biosynthesis/translation initiation factor 2B, gamma/epsilon subunits (eIF-2Bgamma/eIF-2Bepsilon) [Cell envelope biogenesis, outer membrane / Translation, ribosomal structure...; Region: GCD1; COG1208 755731001233 NTP_transferases catalyze the transfer of nucleotides onto phosphosugars; Region: NTP_transferase; cd04181 755731001234 active site 755731001235 Substrate binding site; other site 755731001236 Mg++ binding site; other site 755731001237 Left-handed parallel beta-Helix (LbetaH or LbH) domain: The alignment contains 5 turns, each containing three imperfect tandem repeats of a hexapeptide repeat motif (X-[STAV]-X-[LIV]-[GAED]-X). Proteins containing hexapeptide repeats are often enzymes...; Region: LbetaH; cl00160 755731001238 putative trimer interface [polypeptide binding]; other site 755731001239 Left-handed parallel beta-Helix (LbetaH or LbH) domain: The alignment contains 5 turns, each containing three imperfect tandem repeats of a hexapeptide repeat motif (X-[STAV]-X-[LIV]-[GAED]-X). Proteins containing hexapeptide repeats are often enzymes...; Region: LbetaH; cl00160 755731001240 putative CoA binding site [chemical binding]; other site 755731001241 putative trimer interface [polypeptide binding]; other site 755731001242 putative CoA binding site [chemical binding]; other site 755731001243 phosphoglucosamine mutase; Region: Arch_GlmM; TIGR03990 755731001244 GTP-mannose-1-phosphate guanyltransferase (MPG1 transferase), also known as GDP-mannose pyrophosphorylase, is a bifunctional enzyme with both phosphomannose isomerase (PMI) activity and GDP-mannose phosphorylase (GMP) activity. The protein contains an...; Region: MPG1_transferase; cd05805 755731001245 Predicted membrane protein [Function unknown]; Region: COG2246 755731001246 GtrA-like protein; Region: GtrA; pfam04138 755731001247 Predicted membrane protein (DUF2238); Region: DUF2238; pfam09997 755731001248 putative UV damage endonuclease; Provisional; Region: uvsE; PRK02308 755731001249 Transcriptional accessory protein [Transcription]; Region: Tex; COG2183 755731001250 Tex-like protein N-terminal domain; Region: Tex_N; pfam09371 755731001251 Likely ribonuclease with RNase H fold; Region: YqgFc; smart00732 755731001252 S1_Tex: The C-terminal S1 domain of a transcription accessory factor called Tex, which has been characterized in Bordetella pertussis and Pseudomonas aeruginosa. The tex gene is essential in Bortella pertusis and is named for its role in toxin expression; Region: S1_Tex; cd05685 755731001253 RNA binding site [nucleotide binding]; other site 755731001254 thioredoxin-disulfide reductase; Region: TRX_reduct; TIGR01292 755731001255 Anaerobic glycerol-3-phosphate dehydrogenase [Amino acid transport and metabolism]; Region: GlpB; cl17730 755731001256 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 755731001257 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 755731001258 ATP binding site [chemical binding]; other site 755731001259 Mg2+ binding site [ion binding]; other site 755731001260 G-X-G motif; other site 755731001261 Sporulation and spore germination; Region: Germane; pfam10646 755731001262 Zinc ribbon domain; Region: CxxC_CxxC_SSSS; pfam09723 755731001263 Ku protein, prokaryotic; Region: Ku_bact; TIGR02772 755731001264 Ku-core domain, Ku-like subfamily; composed of prokaryotic homologs of the eukaryotic DNA binding protein Ku. The alignment includes the core domain shared by the prokaryotic YkoV-like proteins and the eukaryotic Ku70 and Ku80. The prokaryotic Ku...; Region: KU_like; cd00789 755731001265 putative DNA binding site [nucleotide binding]; other site 755731001266 putative homodimer interface [polypeptide binding]; other site 755731001267 Adenylation domain of Mycobacterium tuberculosis LigD and LigC-like ATP-dependent DNA ligases; Region: Adenylation_DNA_ligase_LigD_LigC; cd07906 755731001268 DNA polymerase LigD, ligase domain; Region: NHEJ_ligase_lig; TIGR02779 755731001269 active site 755731001270 DNA binding site [nucleotide binding] 755731001271 The Oligonucleotide/oligosaccharide binding (OB)-fold domain of ATP-dependent DNA ligase LigD is a DNA-binding module that is part of the catalytic core unit; Region: OBF_DNA_ligase_LigD; cd07971 755731001272 DNA binding site [nucleotide binding] 755731001273 AE_Prim_S_like: primase domain similar to that found in the small subunit of archaeal and eukaryotic (A/E) DNA primases. The replication machineries of A/Es are distinct from that of bacteria. Primases are DNA-dependent RNA polymerases which synthesis...; Region: AE_Prim_S_like; cl01287 755731001274 nucleotide binding site [chemical binding]; other site 755731001275 UDP-glucose 4 epimerase, subgroup 1, extended (e) SDRs; Region: UDP_G4E_1_SDR_e; cd05247 755731001276 UDP-glucose 4-epimerase; Region: PLN02240 755731001277 NAD binding site [chemical binding]; other site 755731001278 homodimer interface [polypeptide binding]; other site 755731001279 active site 755731001280 substrate binding site [chemical binding]; other site 755731001281 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394 755731001282 active site 755731001283 Probable zinc-binding domain; Region: zf-trcl; pfam13451 755731001284 CxxC-x17-CxxC domain; Region: cxxc_cxxc_Mbark; TIGR04272 755731001285 RaiA ("ribosome-associated inhibitor A", also known as Protein Y (PY), YfiA, and SpotY, is a stress-response protein that binds the ribosomal subunit interface and arrests translation by interfering with aminoacyl-tRNA binding to the ribosomal...; Region: RaiA; cd00552 755731001286 30S subunit binding site; other site 755731001287 Phosphoglycerol transferase and related proteins, alkaline phosphatase superfamily [Cell envelope biogenesis, outer membrane]; Region: MdoB; COG1368 755731001288 Sulfatase; Region: Sulfatase; cl17466 755731001289 shikimate kinase; Reviewed; Region: aroK; PRK00131 755731001290 Shikimate kinase (SK) is the fifth enzyme in the shikimate pathway, a seven-step biosynthetic pathway which converts erythrose-4-phosphate to chorismic acid, found in bacteria, fungi and plants. Chorismic acid is a important intermediate in the synthesis...; Region: SK; cd00464 755731001291 ADP binding site [chemical binding]; other site 755731001292 magnesium binding site [ion binding]; other site 755731001293 putative shikimate binding site; other site 755731001294 Superfamily I DNA and RNA helicases [DNA replication, recombination, and repair]; Region: UvrD; COG0210 755731001295 Part of AAA domain; Region: AAA_19; pfam13245 755731001296 Family description; Region: UvrD_C_2; pfam13538 755731001297 Glycosyl hydrolase family 1; Region: Glyco_hydro_1; cl01046 755731001298 beta-galactosidase; Region: BGL; TIGR03356 755731001299 RNA polymerase sigma factor, sigma-70 family; Region: sigma70-ECF; TIGR02937 755731001300 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 755731001301 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 755731001302 DNA binding residues [nucleotide binding] 755731001303 Putative zinc-finger; Region: zf-HC2; pfam13490 755731001304 Protein of unknown function (DUF2953); Region: DUF2953; pfam11167 755731001305 Sporulation protein YtfJ (Spore_YtfJ); Region: Spore_YtfJ; cl01596 755731001306 Cellulase (glycosyl hydrolase family 5); Region: Cellulase; pfam00150 755731001307 F5/8 type C domain; Region: F5_F8_type_C; pfam00754 755731001308 sugar binding site [chemical binding]; other site 755731001309 Carbohydrate binding domain X2; Region: CBM_X2; pfam03442 755731001310 Carbohydrate binding domain X2; Region: CBM_X2; pfam03442 755731001311 Dockerin type I repeat; Region: Dockerin_1; pfam00404 755731001312 ATP phosphoribosyltransferase regulatory subunit; Provisional; Region: hisZ; PRK12292 755731001313 Class II Histidinyl-tRNA synthetase (HisRS)-like catalytic core domain. HisRS is a homodimer. It is responsible for the attachment of histidine to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for...; Region: HisRS-like_core; cd00773 755731001314 dimer interface [polypeptide binding]; other site 755731001315 motif 1; other site 755731001316 active site 755731001317 motif 2; other site 755731001318 motif 3; other site 755731001319 HGTP anticodon binding domain, as found at the C-terminus of histidyl, glycyl, threonyl and prolyl tRNA synthetases, which are classified as a group of class II aminoacyl-tRNA synthetases (aaRS). In aaRSs, the anticodon binding domain is responsible for...; Region: HGTP_anticodon; cl00266 755731001320 anticodon binding site; other site 755731001321 ATP phosphoribosyltransferase catalytic subunit; Reviewed; Region: hisG; PRK01686 755731001322 ATP phosphoribosyltransferase [Amino acid transport and metabolism]; Region: HisG; COG0040 755731001323 Histidinol dehydrogenase, HisD, E.C 1.1.1.23. Histidinol dehydrogenase catalyzes the last two steps in the L-histidine biosynthesis pathway, which is conserved in bacteria, archaea, fungi, and plants. These last two steps are (i) the NAD-dependent...; Region: Histidinol_dh; cd06572 755731001324 histidinol dehydrogenase; Region: hisD; TIGR00069 755731001325 NAD binding site [chemical binding]; other site 755731001326 dimerization interface [polypeptide binding]; other site 755731001327 product binding site; other site 755731001328 substrate binding site [chemical binding]; other site 755731001329 zinc binding site [ion binding]; other site 755731001330 catalytic residues [active] 755731001331 histidinol-phosphate aminotransferase; Region: hisC; TIGR01141 755731001332 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 755731001333 pyridoxal 5'-phosphate binding site [chemical binding]; other site 755731001334 homodimer interface [polypeptide binding]; other site 755731001335 catalytic residue [active] 755731001336 Imidazoleglycerol-phosphate dehydratase; Region: IGPD; cd07914 755731001337 putative active site pocket [active] 755731001338 4-fold oligomerization interface [polypeptide binding]; other site 755731001339 metal binding residues [ion binding]; metal-binding site 755731001340 3-fold/trimer interface [polypeptide binding]; other site 755731001341 non-metazoan 5-aminoimidazole-4-(N-succinylcarboxamide) ribonucleotide (SAICAR) synthase; Region: SAICAR_synt_Sc; cd01414 755731001342 ATP binding site [chemical binding]; other site 755731001343 active site 755731001344 phosphoribosylaminoimidazole-succinocarboxamide synthase; Reviewed; Region: PRK09362 755731001345 substrate binding site [chemical binding]; other site 755731001346 imidazole glycerol phosphate synthase subunit HisH; Provisional; Region: hisH; PRK13141 755731001347 Type 1 glutamine amidotransferase (GATase1) domain found in imidazole glycerol phosphate synthase (IGPS); Region: GATase1_IGP_Synthase; cd01748 755731001348 putative active site [active] 755731001349 oxyanion strand; other site 755731001350 catalytic triad [active] 755731001351 HisA. Phosphoribosylformimino-5-aminoimidazole carboxamide ribonucleotide (ProFAR) isomerase catalyzes the fourth step in histidine biosynthesis, an isomerisation of the aminoaldose moiety of ProFAR to the aminoketose of PRFAR (N-(5'-phospho-D-1...; Region: HisA; cd04732 755731001352 phosphoribosylformimino-5-aminoimidazole carboxamide ribotide isomerase; Region: TIGR00007 755731001353 catalytic residues [active] 755731001354 The cyclase subunit of imidazoleglycerol phosphate synthase (HisF). Imidazole glycerol phosphate synthase (IGPS) catalyzes the fifth step of histidine biosynthesis, the formation of the imidazole ring. IGPS converts N1-(5'-phosphoribulosyl)...; Region: HisF; cd04731 755731001355 Histidine biosynthesis protein; Region: His_biosynth; pfam00977 755731001356 substrate binding site [chemical binding]; other site 755731001357 glutamase interaction surface [polypeptide binding]; other site 755731001358 bifunctional phosphoribosyl-AMP cyclohydrolase/phosphoribosyl-ATP pyrophosphatase protein; Reviewed; Region: PRK02759 755731001359 phosphoribosyl-AMP cyclohydrolase; Reviewed; Region: hisI; PRK00051 755731001360 Nucleoside Triphosphate Pyrophosphohydrolase (EC 3.6.1.8) MazG-like domain found in Escherichia coli phosphoribosyl-ATP pyrophosphohydrolase (HisIE or PRATP-PH) and its homologs; Region: NTP-PPase_HisIE_like; cd11534 755731001361 metal binding site [ion binding]; metal-binding site 755731001362 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 755731001363 binding surface 755731001364 TPR motif; other site 755731001365 Chaperonin 10 Kd subunit (cpn10 or GroES); Cpn10 cooperates with chaperonin 60 (cpn60 or GroEL), an ATPase, to assist the folding and assembly of proteins and is found in eubacterial cytosol, as well as in the matrix of mitochondria and chloroplasts. It...; Region: cpn10; cd00320 755731001366 oligomerisation interface [polypeptide binding]; other site 755731001367 mobile loop; other site 755731001368 roof hairpin; other site 755731001369 chaperonin GroEL; Reviewed; Region: groEL; PRK12849 755731001370 GroEL_like type I chaperonin. Chaperonins are involved in productive folding of proteins. They share a common general morphology, a double toroid of 2 stacked rings, each composed of 7-9 subunits. The symmetry of type I is seven-fold and they are found...; Region: GroEL; cd03344 755731001371 ring oligomerisation interface [polypeptide binding]; other site 755731001372 ATP/Mg binding site [chemical binding]; other site 755731001373 stacking interactions; other site 755731001374 hinge regions; other site 755731001375 inosine 5-monophosphate dehydrogenase; Validated; Region: PRK07107 755731001376 TIM barrel proteins share a structurally conserved phosphate binding motif and in general share an eight beta/alpha closed barrel structure. Specific for this family is the conserved phosphate binding site at the edges of strands 7 and 8. The phosphate...; Region: TIM_phosphate_binding; cl17186 755731001377 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains in the inosine 5' monophosphate dehydrogenase (IMPDH) protein. IMPDH is an essential enzyme that catalyzes the first step unique to GTP synthesis, playing a...; Region: CBS_pair_IMPDH_2; cd04602 755731001378 IMPDH: The catalytic domain of the inosine monophosphate dehydrogenase. IMPDH catalyzes the NAD-dependent oxidation of inosine 5'-monophosphate (IMP) to xanthosine 5' monophosphate (XMP). It is a rate-limiting step in the de novo synthesis of...; Region: IMPDH; cd00381 755731001379 active site 755731001380 Transcription elongation factor, N-terminal; Region: GreA_GreB_N; pfam03449 755731001381 transcription elongation factor GreA; Reviewed; Region: greA; PRK00226 755731001382 Transcription elongation factor, GreA/GreB, C-term; Region: GreA_GreB; pfam01272 755731001383 lysyl-tRNA synthetase; Reviewed; Region: lysS; PRK00484 755731001384 LysRS_N: N-terminal, anticodon recognition domain of lysyl-tRNA synthetases (LysRS). These enzymes are homodimeric class 2b aminoacyl-tRNA synthetases (aaRSs). This domain is a beta-barrel domain (OB fold) involved in binding the tRNA anticodon stem-loop; Region: LysRS_N; cd04322 755731001385 dimer interface [polypeptide binding]; other site 755731001386 putative anticodon binding site; other site 755731001387 Lys_tRNA synthetase (LysRS) class II core domain. Class II LysRS is a dimer which attaches a lysine to the 3' OH group of ribose of the appropriate tRNA. Its assignment to class II aaRS is based upon its structure and the presence of three...; Region: LysRS_core; cd00775 755731001388 motif 1; other site 755731001389 active site 755731001390 motif 2; other site 755731001391 motif 3; other site 755731001392 chaperone protein DnaJ; Provisional; Region: PRK14291 755731001393 Sulphate Transporter and Anti-Sigma factor antagonist) domain of anti-anti-sigma factors, key regulators of anti-sigma factors by phosphorylation; Region: STAS_anti-anti-sigma_factors; cd07043 755731001394 anti sigma factor interaction site; other site 755731001395 regulatory phosphorylation site [posttranslational modification]; other site 755731001396 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cl00075 755731001397 Histidine kinase-like ATPase domain; Region: HATPase_c_2; pfam13581 755731001398 RNA polymerase sigma-70 factor, sigma-B/F/G subfamily; Region: SigBFG; TIGR02980 755731001399 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 755731001400 Sigma-70 region 3; Region: Sigma70_r3; pfam04539 755731001401 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 755731001402 DNA binding residues [nucleotide binding] 755731001403 Histidine kinase-like ATPase domain; Region: HATPase_c_2; pfam13581 755731001404 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cl00075 755731001405 ATP binding site [chemical binding]; other site 755731001406 Mg2+ binding site [ion binding]; other site 755731001407 G-X-G motif; other site 755731001408 30S ribosomal protein S10; Reviewed; Region: rpsJ; PRK00596 755731001409 50S ribosomal protein L3; Validated; Region: rplC; PRK00001 755731001410 50S ribosomal protein L4; Provisional; Region: rplD; PRK05319 755731001411 50S ribosomal protein L23; Reviewed; Region: rplW; PRK05738 755731001412 50S ribosomal protein L2; Validated; Region: rplB; PRK09374 755731001413 Ribosomal Proteins L2, RNA binding domain; Region: Ribosomal_L2; pfam00181 755731001414 Ribosomal Proteins L2, C-terminal domain; Region: Ribosomal_L2_C; pfam03947 755731001415 30S ribosomal protein S19; Reviewed; Region: rpsS; PRK00357 755731001416 Ribosomal protein L22/L17e. L22 (L17 in eukaryotes) is a core protein of the large ribosomal subunit. It is the only ribosomal protein that interacts with all six domains of 23S rRNA, and is one of the proteins important for directing the proper...; Region: Ribosomal_L22; cd00336 755731001417 putative translocon binding site; other site 755731001418 protein-rRNA interface [nucleotide binding]; other site 755731001419 30S ribosomal protein S3; Reviewed; Region: rpsC; PRK00310 755731001420 K homology RNA-binding (KH) domain of the prokaryotic 30S small ribosomal subunit protein S3. S3 is part of the head region of the 30S ribosomal subunit and is believed to interact with mRNA as it threads its way from the latch into the channel. The KH...; Region: 30S_S3_KH; cd02412 755731001421 G-X-X-G motif; other site 755731001422 Ribosomal protein S3, C-terminal domain; Region: Ribosomal_S3_C; pfam00189 755731001423 Ribosomal_L16_L10e: L16 is an essential protein in the large ribosomal subunit of bacteria, mitochondria, and chloroplasts. Large subunits that lack L16 are defective in peptidyl transferase activity, peptidyl-tRNA hydrolysis activity, association with...; Region: Ribosomal_L16_L10e; cd01433 755731001424 23S rRNA interface [nucleotide binding]; other site 755731001425 5S rRNA interface [nucleotide binding]; other site 755731001426 putative antibiotic binding site [chemical binding]; other site 755731001427 L25 interface [polypeptide binding]; other site 755731001428 L27 interface [polypeptide binding]; other site 755731001429 Ribosomal L29 protein/HIP. L29 is a protein of the large ribosomal Subunit. A homolog, called heparin/heparan sulfate interacting protein (HIP), has also been identified in mammals. L29 is located on the surface of the large ribosomal subunit, where it...; Region: Ribosomal_L29_HIP; cd00427 755731001430 23S rRNA interface [nucleotide binding]; other site 755731001431 putative translocon interaction site; other site 755731001432 signal recognition particle (SRP54) interaction site; other site 755731001433 L23 interface [polypeptide binding]; other site 755731001434 trigger factor interaction site; other site 755731001435 30S ribosomal protein S17; Reviewed; Region: rpsQ; PRK05610 755731001436 50S ribosomal protein L14; Validated; Region: rplN; PRK05483 755731001437 50S ribosomal protein L24; Reviewed; Region: rplX; PRK00004 755731001438 KOW motif of Ribosomal Protein L26; Region: KOW_RPL26; cd06089 755731001439 RNA binding site [nucleotide binding]; other site 755731001440 Protein of unknown function (DUF2614); Region: DUF2614; cl07936 755731001441 50S ribosomal protein L5; Validated; Region: rplE; PRK00010 755731001442 Ribosomal protein L5; Region: Ribosomal_L5; pfam00281 755731001443 ribosomal L5P family C-terminus; Region: Ribosomal_L5_C; pfam00673 755731001444 30S ribosomal protein S14; Reviewed; Region: rpsN; PRK08061 755731001445 30S ribosomal protein S8; Validated; Region: rpsH; PRK00136 755731001446 50S ribosomal protein L6; Validated; Region: rplF; PRK05498 755731001447 Ribosomal protein L6; Region: Ribosomal_L6; pfam00347 755731001448 Ribosomal protein L6; Region: Ribosomal_L6; pfam00347 755731001449 Ribosomal L18/L5e: L18 (L5e) is a ribosomal protein found in the central protuberance (CP) of the large subunit. L18 binds 5S rRNA and induces a conformational change that stimulates the binding of L5 to 5S rRNA. Association of 5S rRNA with 23S rRNA...; Region: Ribosomal_L18_L5e; cd00432 755731001450 23S rRNA interface [nucleotide binding]; other site 755731001451 5S rRNA interface [nucleotide binding]; other site 755731001452 L27 interface [polypeptide binding]; other site 755731001453 L5 interface [polypeptide binding]; other site 755731001454 30S ribosomal protein S5; Validated; Region: rpsE; PRK00550 755731001455 Ribosomal protein S5, N-terminal domain; Region: Ribosomal_S5; pfam00333 755731001456 Ribosomal protein S5, C-terminal domain; Region: Ribosomal_S5_C; pfam03719 755731001457 Ribosomal protein L30, which is found in eukaryotes and prokaryotes but not in archaea, is one of the smallest ribosomal proteins with a molecular mass of about 7kDa. L30 binds the 23SrRNA as well as the 5S rRNA and is one of five ribosomal proteins that...; Region: Ribosomal_L30; cd01658 755731001458 23S rRNA binding site [nucleotide binding]; other site 755731001459 50S ribosomal protein L15; Reviewed; Region: rplO; PRK05592 755731001460 preprotein translocase subunit SecY; Reviewed; Region: secY; PRK09204 755731001461 SecY translocase; Region: SecY; pfam00344 755731001462 adenylate kinase; Reviewed; Region: adk; PRK00279 755731001463 Adenylate kinase (ADK) catalyzes the reversible phosphoryl transfer from adenosine triphosphates (ATP) to adenosine monophosphates (AMP) and to yield adenosine diphosphates (ADP). This enzyme is required for the biosynthesis of ADP and is essential for...; Region: ADK; cd01428 755731001464 AMP-binding site [chemical binding]; other site 755731001465 ATP-AMP (Ap5A)-binding site [chemical binding]; other site 755731001466 Methionine Aminopeptidase 1. E.C. 3.4.11.18. Also known as methionyl aminopeptidase and Peptidase M. Catalyzes release of N-terminal amino acids, preferentially methionine, from peptides and arylamides; Region: MetAP1; cd01086 755731001467 active site 755731001468 KOW motif of Ribosomal Protein L14; Region: KOW_RPL14; cd06088 755731001469 RNA binding site [nucleotide binding]; other site 755731001470 S1_IF1: Translation Initiation Factor IF1, S1-like RNA-binding domain. IF1 contains an S1-like RNA-binding domain, which is found in a wide variety of RNA-associated proteins. Translation initiation includes a number of interrelated steps preceding the...; Region: S1_IF1; cd04451 755731001471 rRNA binding site [nucleotide binding]; other site 755731001472 predicted 30S ribosome binding site; other site 755731001473 50S ribosomal protein L36; Reviewed; Region: rpmJ; PRK00465 755731001474 Ribosomal protein S13 [Translation, ribosomal structure and biogenesis]; Region: RpsM; COG0099 755731001475 30S ribosomal protein S13; Region: bact_S13; TIGR03631 755731001476 30S ribosomal protein S11; Validated; Region: PRK05309 755731001477 30S ribosomal protein S4; Validated; Region: rpsD; PRK05327 755731001478 Ribosomal protein S4/S9 N-terminal domain; Region: Ribosomal_S4; pfam00163 755731001479 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 755731001480 RNA binding surface [nucleotide binding]; other site 755731001481 DNA-directed RNA polymerase subunit alpha; Provisional; Region: PRK05182 755731001482 N-terminal domain of the Alpha subunit of Bacterial RNA polymerase; Region: RNAP_alpha_NTD; cd06928 755731001483 alphaNTD homodimer interface [polypeptide binding]; other site 755731001484 alphaNTD - beta interaction site [polypeptide binding]; other site 755731001485 alphaNTD - beta' interaction site [polypeptide binding]; other site 755731001486 Bacterial RNA polymerase, alpha chain C terminal domain; Region: RNA_pol_A_CTD; pfam03118 755731001487 50S ribosomal protein L17; Validated; Region: rplQ; PRK05591 755731001488 cobalt transporter ATP-binding subunit; Provisional; Region: PRK13633 755731001489 First domain of the ATP-binding cassette component of cobalt transport system; Region: ABC_cobalt_CbiO_domain1; cd03225 755731001490 Walker A/P-loop; other site 755731001491 ATP binding site [chemical binding]; other site 755731001492 Q-loop/lid; other site 755731001493 ABC transporter signature motif; other site 755731001494 Walker B; other site 755731001495 D-loop; other site 755731001496 H-loop/switch region; other site 755731001497 16S RNA G1207 methylase RsmC [Translation, ribosomal structure and biogenesis]; Region: RsmC; COG2813 755731001498 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 755731001499 S-adenosylmethionine binding site [chemical binding]; other site 755731001500 cobalt transporter ATP-binding subunit; Provisional; Region: cbiO; PRK13637 755731001501 First domain of the ATP-binding cassette component of cobalt transport system; Region: ABC_cobalt_CbiO_domain1; cd03225 755731001502 Walker A/P-loop; other site 755731001503 ATP binding site [chemical binding]; other site 755731001504 Q-loop/lid; other site 755731001505 ABC transporter signature motif; other site 755731001506 Walker B; other site 755731001507 D-loop; other site 755731001508 H-loop/switch region; other site 755731001509 ABC-type cobalt transport system, permease component CbiQ and related transporters [Inorganic ion transport and metabolism]; Region: CbiQ; COG0619 755731001510 tRNA pseudouridine synthase A; Validated; Region: truA; PRK00021 755731001511 Eukaryotic and bacterial pseudouridine synthases similar to E. coli TruA; Region: PseudoU_synth_EcTruA; cd02570 755731001512 dimerization interface 3.5A [polypeptide binding]; other site 755731001513 active site 755731001514 Ribosomal protein L13. Protein L13, a large ribosomal subunit protein, is one of five proteins required for an early folding intermediate of 23S rRNA in the assembly of the large subunit. L13 is situated on the bottom of the large subunit, near the...; Region: Ribosomal_L13; cd00392 755731001515 23S rRNA interface [nucleotide binding]; other site 755731001516 L3 interface [polypeptide binding]; other site 755731001517 30S ribosomal protein S9; Reviewed; Region: rpsI; PRK00132 755731001518 Site-specific recombinases, DNA invertase Pin homologs [DNA replication, recombination, and repair]; Region: PinR; COG1961 755731001519 Serine Recombinase family, catalytic domain; a DNA binding domain may be present either N- or C-terminal to the catalytic domain. These enzymes perform site-specific recombination of DNA molecules by a concerted, four-strand cleavage and rejoining...; Region: Ser_Recombinase; cl02788 755731001520 catalytic residues [active] 755731001521 catalytic nucleophile [active] 755731001522 Recombinase; Region: Recombinase; pfam07508 755731001523 Recombinase zinc beta ribbon domain; Region: Zn_ribbon_recom; pfam13408 755731001524 (acyl-carrier-protein) S-malonyltransferase [Lipid metabolism]; Region: FabD; COG0331 755731001525 malonyl CoA-acyl carrier protein transacylase; Region: fabD; TIGR00128 755731001526 polyketide synthases (PKSs) polymerize simple fatty acids into a large variety of different products, called polyketides, by successive decarboxylating Claisen condensations. PKSs can be divided into 2 groups, modular type I PKSs consisting of one or...; Region: PKS; cd00833 755731001527 Beta-ketoacyl synthase; Region: PKS_KS; smart00825 755731001528 active site 755731001529 Dehydratase domain in polyketide synthase (PKS) enzymes; Region: PKS_DH; smart00826 755731001530 ketoreductase (KR), subgroup 2, complex (x) SDRs; Region: KR_2_SDR_x; cd08953 755731001531 putative NADP binding site [chemical binding]; other site 755731001532 KR domain; Region: KR; pfam08659 755731001533 active site 755731001534 Phosphopantetheine attachment site; Region: PP-binding; pfam00550 755731001535 polyketide synthases (PKSs) polymerize simple fatty acids into a large variety of different products, called polyketides, by successive decarboxylating Claisen condensations. PKSs can be divided into 2 groups, modular type I PKSs consisting of one or...; Region: PKS; cd00833 755731001536 Beta-ketoacyl synthase; Region: PKS_KS; smart00825 755731001537 active site 755731001538 Dehydratase domain in polyketide synthase (PKS) enzymes; Region: PKS_DH; smart00826 755731001539 ketoreductase (KR), subgroup 2, complex (x) SDRs; Region: KR_2_SDR_x; cd08953 755731001540 This enzymatic domain is part of bacterial polyketide synthases; Region: PKS_KR; smart00822 755731001541 putative NADP binding site [chemical binding]; other site 755731001542 active site 755731001543 Phosphopantetheine attachment site; Region: PP-binding; pfam00550 755731001544 (acyl-carrier-protein) S-malonyltransferase [Lipid metabolism]; Region: FabD; COG0331 755731001545 polyketide synthases (PKSs) polymerize simple fatty acids into a large variety of different products, called polyketides, by successive decarboxylating Claisen condensations. PKSs can be divided into 2 groups, modular type I PKSs consisting of one or...; Region: PKS; cd00833 755731001546 Beta-ketoacyl synthase; Region: PKS_KS; smart00825 755731001547 active site 755731001548 Predicted transcriptional regulators [Transcription]; Region: COG1695 755731001549 Transcriptional regulator PadR-like family; Region: PadR; pfam03551 755731001550 ABC-type multidrug transport system, ATPase component [Defense mechanisms]; Region: CcmA; COG1131 755731001551 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 755731001552 Walker A/P-loop; other site 755731001553 ATP binding site [chemical binding]; other site 755731001554 Q-loop/lid; other site 755731001555 ABC transporter signature motif; other site 755731001556 Walker B; other site 755731001557 D-loop; other site 755731001558 H-loop/switch region; other site 755731001559 ABC-type multidrug transport system, permease component [Defense mechanisms]; Region: COG0842 755731001560 ABC-2 type transporter; Region: ABC2_membrane; pfam01061 755731001561 ABC-type multidrug transport system, permease component [Defense mechanisms]; Region: COG0842 755731001562 ABC-2 type transporter; Region: ABC2_membrane; pfam01061 755731001563 B12 binding domain_like associated with radical SAM domain. This domain shows similarity with B12 (adenosylcobamide) binding domains found in several enzymes, such as glutamate mutase, methionine synthase and methylmalonyl-CoA mutase, but it lacks the...; Region: radical_SAM_B12_BD; cd02068 755731001564 Elongator protein 3, MiaB family, Radical SAM; Region: Elp3; smart00729 755731001565 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 755731001566 FeS/SAM binding site; other site 755731001567 Non-ribosomal peptide synthetase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: EntF; COG1020 755731001568 HxxPF-repeated domain; Region: HxxPF_rpt; pfam13745 755731001569 The adenylation domain of nonribosomal peptide synthetases (NRPS); Region: A_NRPS; cd05930 755731001570 acyl-activating enzyme (AAE) consensus motif; other site 755731001571 AMP binding site [chemical binding]; other site 755731001572 Phosphopantetheine attachment site; Region: PP-binding; pfam00550 755731001573 Condensation domain; Region: Condensation; pfam00668 755731001574 Non-ribosomal peptide synthetase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: EntF; COG1020 755731001575 HxxPF-repeated domain; Region: HxxPF_rpt; pfam13745 755731001576 The adenylation domain of nonribosomal peptide synthetases (NRPS); Region: A_NRPS; cd05930 755731001577 acyl-activating enzyme (AAE) consensus motif; other site 755731001578 AMP binding site [chemical binding]; other site 755731001579 Phosphopantetheine attachment site; Region: PP-binding; pfam00550 755731001580 Condensation domain; Region: Condensation; pfam00668 755731001581 non-ribosomal peptide synthase domain TIGR01720; Region: NRPS-para261 755731001582 Thioesterase domain; Region: Thioesterase; pfam00975 755731001583 Condensation domain; Region: Condensation; pfam00668 755731001584 Non-ribosomal peptide synthetase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: EntF; COG1020 755731001585 The adenylation domain of nonribosomal peptide synthetases (NRPS); Region: A_NRPS; cd05930 755731001586 acyl-activating enzyme (AAE) consensus motif; other site 755731001587 AMP binding site [chemical binding]; other site 755731001588 Phosphopantetheine attachment site; Region: PP-binding; pfam00550 755731001589 Condensation domain; Region: Condensation; pfam00668 755731001590 Non-ribosomal peptide synthetase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: EntF; COG1020 755731001591 HxxPF-repeated domain; Region: HxxPF_rpt; pfam13745 755731001592 The adenylation domain of nonribosomal peptide synthetases (NRPS); Region: A_NRPS; cd05930 755731001593 acyl-activating enzyme (AAE) consensus motif; other site 755731001594 AMP binding site [chemical binding]; other site 755731001595 Phosphopantetheine attachment site; Region: PP-binding; pfam00550 755731001596 Condensation domain; Region: Condensation; pfam00668 755731001597 Non-ribosomal peptide synthetase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: EntF; COG1020 755731001598 HxxPF-repeated domain; Region: HxxPF_rpt; pfam13745 755731001599 The adenylation domain of nonribosomal peptide synthetases (NRPS); Region: A_NRPS; cd05930 755731001600 acyl-activating enzyme (AAE) consensus motif; other site 755731001601 AMP binding site [chemical binding]; other site 755731001602 Phosphopantetheine attachment site; Region: PP-binding; pfam00550 755731001603 Condensation domain; Region: Condensation; pfam00668 755731001604 Non-ribosomal peptide synthetase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: EntF; COG1020 755731001605 HxxPF-repeated domain; Region: HxxPF_rpt; pfam13745 755731001606 The adenylation domain of nonribosomal peptide synthetases (NRPS), including Bacillus subtilis termination module Surfactin (SrfA-C); Region: A_NRPS_Srf_like; cd12117 755731001607 acyl-activating enzyme (AAE) consensus motif; other site 755731001608 AMP binding site [chemical binding]; other site 755731001609 Phosphopantetheine attachment site; Region: PP-binding; pfam00550 755731001610 Condensation domain; Region: Condensation; pfam00668 755731001611 Non-ribosomal peptide synthetase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: EntF; COG1020 755731001612 HxxPF-repeated domain; Region: HxxPF_rpt; pfam13745 755731001613 The adenylation domain of nonribosomal peptide synthetases (NRPS), including Bacillus subtilis termination module Surfactin (SrfA-C); Region: A_NRPS_Srf_like; cd12117 755731001614 acyl-activating enzyme (AAE) consensus motif; other site 755731001615 AMP binding site [chemical binding]; other site 755731001616 Phosphopantetheine attachment site; Region: PP-binding; pfam00550 755731001617 Condensation domain; Region: Condensation; pfam00668 755731001618 Non-ribosomal peptide synthetase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: EntF; COG1020 755731001619 HxxPF-repeated domain; Region: HxxPF_rpt; pfam13745 755731001620 The adenylation domain of nonribosomal peptide synthetases (NRPS), including Bacillus subtilis termination module Surfactin (SrfA-C); Region: A_NRPS_Srf_like; cd12117 755731001621 acyl-activating enzyme (AAE) consensus motif; other site 755731001622 AMP binding site [chemical binding]; other site 755731001623 Phosphopantetheine attachment site; Region: PP-binding; pfam00550 755731001624 Condensation domain; Region: Condensation; pfam00668 755731001625 Non-ribosomal peptide synthetase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: EntF; COG1020 755731001626 HxxPF-repeated domain; Region: HxxPF_rpt; pfam13745 755731001627 The adenylation domain of nonribosomal peptide synthetases (NRPS); Region: A_NRPS; cd05930 755731001628 acyl-activating enzyme (AAE) consensus motif; other site 755731001629 AMP binding site [chemical binding]; other site 755731001630 Phosphopantetheine attachment site; Region: PP-binding; pfam00550 755731001631 Mn2+ and Fe2+ transporters of the NRAMP family [Inorganic ion transport and metabolism]; Region: MntH; cl15845 755731001632 manganese transport transcriptional regulator; Provisional; Region: PRK03902 755731001633 Iron dependent repressor, N-terminal DNA binding domain; Region: Fe_dep_repress; pfam01325 755731001634 Imidazolonepropionase and related amidohydrolases [Secondary metabolites biosynthesis, transport, and catabolism]; Region: HutI; COG1228 755731001635 Metallo-dependent hydrolases, subgroup C is part of the superfamily of metallo-dependent hydrolases, a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the...; Region: Met_dep_hydrolase_C; cd01309 755731001636 active site 755731001637 Predicted ATPase or kinase [General function prediction only]; Region: COG0802 755731001638 tRNA threonylcarbamoyl adenosine modification protein YeaZ; Region: T6A_YeaZ; TIGR03725 755731001639 Glycoprotease family; Region: Peptidase_M22; pfam00814 755731001640 ribosomal-protein-alanine acetyltransferase; Region: rimI; TIGR01575 755731001641 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 755731001642 Coenzyme A binding pocket [chemical binding]; other site 755731001643 AAA domain; Region: AAA_32; pfam13654 755731001644 Magnesium chelatase, subunit ChlI; Region: Mg_chelatase; pfam01078 755731001645 Lon protease (S16) C-terminal proteolytic domain; Region: Lon_C; pfam05362 755731001646 RNA polymerase sigma factor SigW; Provisional; Region: PRK09641 755731001647 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 755731001648 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 755731001649 DNA binding residues [nucleotide binding] 755731001650 Predicted integral membrane protein [Function unknown]; Region: COG5660 755731001651 Putative zinc-finger; Region: zf-HC2; pfam13490 755731001652 Histidine-containing phosphocarrier protein (HPr)-like proteins. HPr is a central component of the bacterial phosphoenolpyruvate sugar phosphotransferase system (PTS). The PTS catalyses the phosphorylation of sugar substrates during their translocation...; Region: PTS-HPr_like; cd00367 755731001653 dimerization domain swap beta strand [polypeptide binding]; other site 755731001654 regulatory protein interface [polypeptide binding]; other site 755731001655 active site 755731001656 regulatory phosphorylation site [posttranslational modification]; other site 755731001657 excinuclease ABC subunit C; Validated; Region: uvrC; PRK00558 755731001658 Catalytic GIY-YIG domain of nucleotide excision repair endonucleases UvrC, Cho, and similar proteins; Region: GIY-YIG_UvrC_Cho; cd10434 755731001659 GIY-YIG motif/motif A; other site 755731001660 active site 755731001661 catalytic site [active] 755731001662 putative DNA binding site [nucleotide binding]; other site 755731001663 metal binding site [ion binding]; metal-binding site 755731001664 UvrB/uvrC motif; Region: UVR; pfam02151 755731001665 UvrC Helix-hairpin-helix N-terminal; Region: UvrC_HhH_N; pfam08459 755731001666 metallophosphatase superfamily, metallophosphatase domain; Region: MPP_superfamily; cl13995 755731001667 Calcineurin-like phosphoesterase; Region: Metallophos; pfam00149 755731001668 active site 755731001669 metal binding site [ion binding]; metal-binding site 755731001670 trigger factor; Provisional; Region: tig; PRK01490 755731001671 FKBP-type peptidyl-prolyl cis-trans isomerase; Region: FKBP_C; pfam00254 755731001672 Bacterial trigger factor protein (TF) C-terminus; Region: Trigger_C; pfam05698 755731001673 Clp protease; Region: CLP_protease; pfam00574 755731001674 Caseinolytic protease (ClpP) is an ATP-dependent, highly conserved serine protease; Region: S14_ClpP_2; cd07017 755731001675 oligomer interface [polypeptide binding]; other site 755731001676 active site residues [active] 755731001677 ATP-dependent protease ATP-binding subunit ClpX; Provisional; Region: clpX; PRK05342 755731001678 ClpX C4-type zinc finger; Region: zf-C4_ClpX; pfam06689 755731001679 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 755731001680 Walker A motif; other site 755731001681 ATP binding site [chemical binding]; other site 755731001682 Walker B motif; other site 755731001683 arginine finger; other site 755731001684 C-terminal, D2-small domain, of ClpB protein; Region: ClpB_D2-small; smart01086 755731001685 ATP-dependent protease LonB; Region: spore_lonB; TIGR02902 755731001686 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 755731001687 Walker A motif; other site 755731001688 ATP binding site [chemical binding]; other site 755731001689 Walker B motif; other site 755731001690 arginine finger; other site 755731001691 Lon protease (S16) C-terminal proteolytic domain; Region: Lon_C; pfam05362 755731001692 FtsX-like permease family; Region: FtsX; pfam02687 755731001693 ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136 755731001694 ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255 755731001695 Walker A/P-loop; other site 755731001696 ATP binding site [chemical binding]; other site 755731001697 Q-loop/lid; other site 755731001698 ABC transporter signature motif; other site 755731001699 Walker B; other site 755731001700 D-loop; other site 755731001701 H-loop/switch region; other site 755731001702 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 755731001703 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 755731001704 ATP binding site [chemical binding]; other site 755731001705 Mg2+ binding site [ion binding]; other site 755731001706 G-X-G motif; other site 755731001707 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 755731001708 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 755731001709 active site 755731001710 phosphorylation site [posttranslational modification] 755731001711 intermolecular recognition site; other site 755731001712 dimerization interface [polypeptide binding]; other site 755731001713 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 755731001714 DNA binding site [nucleotide binding] 755731001715 Staphylococcal nuclease homologues; Region: SNc; smart00318 755731001716 Staphylococcal nuclease homologues. SNase homologues are found in bacteria, archaea, and eukaryotes. They contain no disufide bonds; Region: SNc; cl00140 755731001717 Catalytic site; other site 755731001718 UGMP family protein; Validated; Region: PRK09604 755731001719 Inactive homolog of metal-dependent proteases, putative molecular chaperone [Posttranslational modification, protein turnover, chaperones]; Region: COG1214; cl17884 755731001720 Soluble lytic murein transglycosylase and related regulatory proteins (some contain LysM/invasin domains) [Cell envelope biogenesis, outer membrane]; Region: MltE; COG0741 755731001721 Lytic Transglycosylase (LT) and Goose Egg White Lysozyme (GEWL) domain. Members include the soluble and insoluble membrane-bound LTs in bacteria, the LTs in bacteriophage lambda, as well as, the eukaryotic "goose-type" lysozymes (GEWL). LTs...; Region: LT_GEWL; cd00254 755731001722 N-acetyl-D-glucosamine binding site [chemical binding]; other site 755731001723 catalytic residue [active] 755731001724 Protein of unknown function (DUF402); Region: DUF402; pfam04167 755731001725 Predicted metal-dependent phosphoesterases (PHP family) [General function prediction only]; Region: COG0613 755731001726 Polymerase and Histidinol Phosphatase domain of Histidinol phosphate phosphatase (HisPPase) AMP bound; Region: PHP_HisPPase_AMP; cd07438 755731001727 active site 755731001728 Polymerase and Histidinol Phosphatase domain of Histidinol phosphate phosphatase (HisPPase) AMP bound; Region: PHP_HisPPase_AMP; cd07438 755731001729 Small protein B (SmpB) is a component of the trans-translation system in prokaryotes for releasing stalled ribosome from damaged messenger RNAs; Region: SmpB; cd09294 755731001730 SmpB-tmRNA interface; other site 755731001731 Site-specific recombinases, DNA invertase Pin homologs [DNA replication, recombination, and repair]; Region: PinR; COG1961 755731001732 Serine Recombinase family, catalytic domain; a DNA binding domain may be present either N- or C-terminal to the catalytic domain. These enzymes perform site-specific recombination of DNA molecules by a concerted, four-strand cleavage and rejoining...; Region: Ser_Recombinase; cd00338 755731001733 catalytic residues [active] 755731001734 catalytic nucleophile [active] 755731001735 Recombinase; Region: Recombinase; pfam07508 755731001736 Recombinase zinc beta ribbon domain; Region: Zn_ribbon_recom; pfam13408 755731001737 Domain of unknown function (DUF955); Region: DUF955; pfam06114 755731001738 Superfamily of nucleases including Short Patch Repair (Vsr) Endonucleases, archaeal Holliday junction resolvases, MutH methy-directed DNA mismatch-repair endonucleases, and catalytic domains of many restriction endonucleases, such as EcoRI, BamHI, and...; Region: Restriction_endonuclease_like; cl00277 755731001739 putative active site [active] 755731001740 putative active site [active] 755731001741 Superfamily of nucleases including Short Patch Repair (Vsr) Endonucleases, archaeal Holliday junction resolvases, MutH methy-directed DNA mismatch-repair endonucleases, and catalytic domains of many restriction endonucleases, such as EcoRI, BamHI, and...; Region: Restriction_endonuclease_like; cl00277 755731001742 Cytosine-C5 specific DNA methylases; Methyl transfer reactions play an important role in many aspects of biology. Cytosine-specific DNA methylases are found both in prokaryotes and eukaryotes. DNA methylation, or the covalent addition of a methyl group...; Region: Cyt_C5_DNA_methylase; cd00315 755731001743 DNA-methyltransferase (dcm); Region: dcm; TIGR00675 755731001744 cofactor binding site; other site 755731001745 DNA binding site [nucleotide binding] 755731001746 substrate interaction site [chemical binding]; other site 755731001747 Cytosine-C5 specific DNA methylases; Methyl transfer reactions play an important role in many aspects of biology. Cytosine-specific DNA methylases are found both in prokaryotes and eukaryotes. DNA methylation, or the covalent addition of a methyl group...; Region: Cyt_C5_DNA_methylase; cd00315 755731001748 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 755731001749 ATP binding site [chemical binding]; other site 755731001750 putative Mg++ binding site [ion binding]; other site 755731001751 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 755731001752 nucleotide binding region [chemical binding]; other site 755731001753 ATP-binding site [chemical binding]; other site 755731001754 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 755731001755 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 755731001756 sequence-specific DNA binding site [nucleotide binding]; other site 755731001757 salt bridge; other site 755731001758 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 755731001759 non-specific DNA binding site [nucleotide binding]; other site 755731001760 salt bridge; other site 755731001761 sequence-specific DNA binding site [nucleotide binding]; other site 755731001762 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 755731001763 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 755731001764 non-specific DNA binding site [nucleotide binding]; other site 755731001765 salt bridge; other site 755731001766 sequence-specific DNA binding site [nucleotide binding]; other site 755731001767 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 755731001768 non-specific DNA binding site [nucleotide binding]; other site 755731001769 salt bridge; other site 755731001770 sequence-specific DNA binding site [nucleotide binding]; other site 755731001771 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 755731001772 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 755731001773 non-specific DNA binding site [nucleotide binding]; other site 755731001774 salt bridge; other site 755731001775 sequence-specific DNA binding site [nucleotide binding]; other site 755731001776 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 755731001777 non-specific DNA binding site [nucleotide binding]; other site 755731001778 salt bridge; other site 755731001779 sequence-specific DNA binding site [nucleotide binding]; other site 755731001780 SpoVT / AbrB like domain; Region: SpoVT_AbrB; smart00966 755731001781 Nucleoside 2-deoxyribosyltransferase; Region: Nuc_deoxyrib_tr; pfam05014 755731001782 DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213 755731001783 active site 755731001784 DNA binding site [nucleotide binding] 755731001785 Int/Topo IB signature motif; other site 755731001786 Restriction endonuclease [Defense mechanisms]; Region: McrA; COG1403 755731001787 HNH nucleases; HNH endonuclease signature which is found in viral, prokaryotic, and eukaryotic proteins. The alignment includes members of the large group of homing endonucleases, yeast intron 1 protein, MutS, as well as bacterial colicins, pyocins, and...; Region: HNHc; cl00083 755731001788 Phage terminase-like protein, large subunit [General function prediction only]; Region: COG4626 755731001789 phage portal protein, HK97 family; Region: portal_HK97; TIGR01537 755731001790 Phage-related protein [Function unknown]; Region: COG4695; cl01923 755731001791 Caudovirus prohead protease; Region: Peptidase_U35; pfam04586 755731001792 phage major capsid protein, HK97 family; Region: major_cap_HK97; TIGR01554 755731001793 Phage capsid family; Region: Phage_capsid; pfam05065 755731001794 Phage-related minor tail protein [Function unknown]; Region: COG5280 755731001795 Phage tail protein; Region: Sipho_tail; pfam05709 755731001796 Phage uncharacterized protein (Phage_XkdX); Region: Phage_XkdX; cl09900 755731001797 Domain of unknown function (DUF1906); Region: DUF1906; pfam08924 755731001798 Phage regulatory protein Rha (Phage_pRha); Region: Phage_pRha; pfam09669 755731001799 RNA polymerase sigma factor SigW; Provisional; Region: PRK09641 755731001800 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 755731001801 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 755731001802 DNA binding residues [nucleotide binding] 755731001803 Esterases and lipases (includes fungal lipases, cholinesterases, etc.) These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cd00312 755731001804 Putative esterase; Region: Esterase; pfam00756 755731001805 Dockerin type I repeat; Region: Dockerin_1; pfam00404 755731001806 Dockerin type I repeat; Region: Dockerin_1; pfam00404 755731001807 DNA/RNA non-specific endonuclease; prokaryotic and eukaryotic double- and single-stranded DNA and RNA endonucleases also present in phosphodiesterases. They exists as monomers and homodimers; Region: NUC; cd00091 755731001808 DNA/RNA non-specific endonuclease; Region: Endonuclease_NS; smart00892 755731001809 active site 755731001810 substrate binding site [chemical binding]; other site 755731001811 Mg2+ binding site [ion binding]; other site 755731001812 Methylenetetrahydrofolate reductase (MTHFR). 5,10-Methylenetetrahydrofolate is reduced to 5-methyltetrahydrofolate by methylenetetrahydrofolate reductase, a cytoplasmic, NAD(P)-dependent enzyme. 5-methyltetrahydrofolate is utilized by methionine synthase...; Region: MTHFR; cd00537 755731001813 FAD binding site [chemical binding]; other site 755731001814 RNA polymerase sigma-70 factor, TIGR02954 family; Region: Sig70_famx3 755731001815 O-Glycosyl hydrolase [Cell envelope biogenesis, outer membrane]; Region: COG5520 755731001816 Dockerin type I repeat; Region: Dockerin_1; pfam00404 755731001817 Dockerin type I repeat; Region: Dockerin_1; pfam00404 755731001818 Copper amine oxidase N-terminal domain; Region: Cu_amine_oxidN1; pfam07833 755731001819 Right handed beta helix region; Region: Beta_helix; pfam13229 755731001820 Carbohydrate binding domain; Region: CBM_4_9; pfam02018 755731001821 N-terminal Early set domain associated with the catalytic domain of cellulase; Region: E_set_Cellulase_N; cd02850 755731001822 Glycosyl hydrolase family 9; Region: Glyco_hydro_9; pfam00759 755731001823 Dockerin type I repeat; Region: Dockerin_1; pfam00404 755731001824 Dockerin type I repeat; Region: Dockerin_1; pfam00404 755731001825 NlpC/P60 family; Region: NLPC_P60; cl17555 755731001826 Putative peptidoglycan-binding domain-containing protein [Cell envelope biogenesis, outer membrane]; Region: COG3409 755731001827 Putative peptidoglycan binding domain; Region: PG_binding_1; pfam01471 755731001828 B12 binding domain (B12-BD). Most of the members bind different cobalamid derivates, like B12 (adenosylcobamide) or methylcobalamin or methyl-Co(III) 5-hydroxybenzimidazolylcobamide. This domain is found in several enzymes, such as glutamate mutase; Region: B12-binding_like; cl00293 755731001829 B12 binding site [chemical binding]; other site 755731001830 Elongator protein 3, MiaB family, Radical SAM; Region: Elp3; smart00729 755731001831 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 755731001832 FeS/SAM binding site; other site 755731001833 LysE type translocator; Region: LysE; cl00565 755731001834 The adenylation domain of nonribosomal peptide synthetases (NRPS); Region: A_NRPS; cd05930 755731001835 amino acid adenylation domain; Region: AA-adenyl-dom; TIGR01733 755731001836 acyl-activating enzyme (AAE) consensus motif; other site 755731001837 AMP binding site [chemical binding]; other site 755731001838 Phosphopantetheine attachment site; Region: PP-binding; pfam00550 755731001839 YjgF, YER057c, and UK114 belong to a large family of proteins present in bacteria, archaea, and eukaryotes with no definitive function. The conserved domain is similar in structure to chorismate mutase but there is no sequence similarity and no...; Region: YjgF_YER057c_UK114_family; cl10015 755731001840 homotrimer interaction site [polypeptide binding]; other site 755731001841 putative active site [active] 755731001842 ABC-2 family transporter protein; Region: ABC2_membrane_6; cl01496 755731001843 ABC-type uncharacterized transport system, permease component [General function prediction only]; Region: COG4587 755731001844 ABC-type uncharacterized transport system, ATPase component [General function prediction only]; Region: COG4586 755731001845 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 755731001846 Walker A/P-loop; other site 755731001847 ATP binding site [chemical binding]; other site 755731001848 Q-loop/lid; other site 755731001849 ABC transporter signature motif; other site 755731001850 Walker B; other site 755731001851 D-loop; other site 755731001852 H-loop/switch region; other site 755731001853 ABC-type uncharacterized transport system, permease component [General function prediction only]; Region: COG4587 755731001854 ABC-2 family transporter protein; Region: ABC2_membrane_6; cl01496 755731001855 3-Oxoacyl-[acyl-carrier-protein (ACP)] synthase III C terminal; Region: ACP_syn_III_C; cl17241 755731001856 Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610 755731001857 Adenosylmethionine-8-amino-7-oxononanoate aminotransferase [Coenzyme metabolism]; Region: BioA; COG0161 755731001858 inhibitor-cofactor binding pocket; inhibition site 755731001859 pyridoxal 5'-phosphate binding site [chemical binding]; other site 755731001860 catalytic residue [active] 755731001861 exosortase A system-associated amidotransferase 1; Region: eps_aminotran_1; TIGR03108 755731001862 Glutamine amidotransferases class-II (GATase) asparagine synthase_B type. Asparagine synthetase B catalyses the ATP-dependent conversion of aspartate to asparagine. This enzyme is a homodimer, with each monomer composed of a glutaminase domain and a...; Region: AsnB; cd00712 755731001863 active site 755731001864 dimer interface [polypeptide binding]; other site 755731001865 The C-terminal domain of Asparagine Synthase B. This domain is always found associated n-terminal amidotransferase domain. Family members that contain this domain catalyse the conversion of aspartate to asparagine. Asparagine synthetase B catalyzes the...; Region: Asn_Synthase_B_C; cd01991 755731001866 Ligand Binding Site [chemical binding]; other site 755731001867 Molecular Tunnel; other site 755731001868 Phosphopantetheine attachment site; Region: PP-binding; pfam00550 755731001869 B12 binding domain_like associated with radical SAM domain. This domain shows similarity with B12 (adenosylcobamide) binding domains found in several enzymes, such as glutamate mutase, methionine synthase and methylmalonyl-CoA mutase, but it lacks the...; Region: radical_SAM_B12_BD; cd02068 755731001870 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 755731001871 Radical SAM superfamily; Region: Radical_SAM; pfam04055 755731001872 FeS/SAM binding site; other site 755731001873 Solo B3/4 domain (OB-fold DNA/RNA-binding) of Phe-aaRS-beta [General function prediction only]; Region: COG3382 755731001874 B3/4 domain; Region: B3_4; pfam03483 755731001875 Aldehyde dehydrogenase family; Region: Aldedh; pfam00171 755731001876 Escherichia coli NADP+-dependent gamma-glutamyl-gamma-aminobutyraldehyde dehydrogenase PuuC-like; Region: ALDH_GABALDH-PuuC; cd07112 755731001877 NAD(P) binding site [chemical binding]; other site 755731001878 catalytic residues [active] 755731001879 Peptidase family C39 mostly contains bacteriocin-processing endopeptidases from bacteria. The cysteine peptidases in family C39 cleave the "double-glycine" leader peptides from the precursors of various bacteriocins (mostly non-lantibiotic); Region: Peptidase_C39_like; cl00296 755731001880 A predicted NlpC/p60-like peptidase; Region: BtrH; pfam14399 755731001881 Uncharacterized Fe-S protein [Energy production and conversion]; Region: COG1600 755731001882 Xaa-His dipeptidase; Region: aa-his-dipept; TIGR01893 755731001883 M20 Peptidase D has specificity for beta-alanyl-L-histidine dipeptide; Region: M20_pepD; cd03890 755731001884 metal binding site [ion binding]; metal-binding site 755731001885 dimer interface [polypeptide binding]; other site 755731001886 putative oligopeptide transporter, OPT family; Region: TIGR00733 755731001887 OPT oligopeptide transporter protein; Region: OPT; cl14607 755731001888 DnaQ-like (or DEDD) 3'-5' exonuclease domain superfamily; Region: DnaQ_like_exo; cl10012 755731001889 active site 755731001890 catalytic site [active] 755731001891 substrate binding site [chemical binding]; other site 755731001892 DEAD-like helicases superfamily; Region: DEXDc; smart00487 755731001893 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 755731001894 ATP binding site [chemical binding]; other site 755731001895 putative Mg++ binding site [ion binding]; other site 755731001896 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 755731001897 nucleotide binding region [chemical binding]; other site 755731001898 ATP-binding site [chemical binding]; other site 755731001899 Superfamily I DNA and RNA helicases [DNA replication, recombination, and repair]; Region: UvrD; COG0210 755731001900 Part of AAA domain; Region: AAA_19; pfam13245 755731001901 Superfamily I DNA and RNA helicases [DNA replication, recombination, and repair]; Region: UvrD; COG0210 755731001902 Family description; Region: UvrD_C_2; pfam13538 755731001903 A predicted NlpC/p60-like peptidase; Region: BtrH; pfam14399 755731001904 AzlC protein; Region: AzlC; cl00570 755731001905 Branched-chain amino acid transport protein (AzlD); Region: AzlD; pfam05437 755731001906 glycerol kinase; Provisional; Region: glpK; PRK00047 755731001907 Escherichia coli glycerol kinase-like proteins; belongs to the FGGY family of carbohydrate kinases; Region: FGGY_EcGK_like; cd07786 755731001908 N- and C-terminal domain interface [polypeptide binding]; other site 755731001909 active site 755731001910 MgATP binding site [chemical binding]; other site 755731001911 catalytic site [active] 755731001912 metal binding site [ion binding]; metal-binding site 755731001913 glycerol binding site [chemical binding]; other site 755731001914 homotetramer interface [polypeptide binding]; other site 755731001915 homodimer interface [polypeptide binding]; other site 755731001916 FBP binding site [chemical binding]; other site 755731001917 protein IIAGlc interface [polypeptide binding]; other site 755731001918 Gamma-glutamyl phosphate reductase (GPR), aldehyde dehydrogenase families 18 and 19; Region: ALDH_F18-19_ProA-GPR; cd07079 755731001919 gamma-glutamyl phosphate reductase; Region: proA; TIGR00407 755731001920 putative catalytic cysteine [active] 755731001921 YjgF, YER057c, and UK114 belong to a large family of proteins present in bacteria, archaea, and eukaryotes with no definitive function. The conserved domain is similar in structure to chorismate mutase but there is no sequence similarity and no...; Region: YjgF_YER057c_UK114_family; cd00448 755731001922 homotrimer interaction site [polypeptide binding]; other site 755731001923 putative active site [active] 755731001924 aspartate-semialdehyde dehydrogenase; Reviewed; Region: PRK08664 755731001925 Semialdehyde dehydrogenase, NAD binding domain; Region: Semialdhyde_dh; smart00859 755731001926 Putative peptidoglycan binding domain; Region: PG_binding_1; pfam01471 755731001927 Uncharacterized protein conserved in bacteria [Function unknown]; Region: ErfK; COG1376 755731001928 L,D-transpeptidase catalytic domain; Region: YkuD; pfam03734 755731001929 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 755731001930 Bacterial extracellular solute-binding proteins, family 3; Region: SBP_bac_3; pfam00497 755731001931 substrate binding pocket [chemical binding]; other site 755731001932 membrane-bound complex binding site; other site 755731001933 hinge residues; other site 755731001934 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 755731001935 dimer interface [polypeptide binding]; other site 755731001936 conserved gate region; other site 755731001937 ABC-ATPase subunit interface; other site 755731001938 ABC-type polar amino acid transport system, ATPase component [Amino acid transport and metabolism]; Region: GlnQ; COG1126 755731001939 ATP-binding cassette domain of the histidine and glutamine transporters; Region: ABC_HisP_GlnQ; cd03262 755731001940 Walker A/P-loop; other site 755731001941 ATP binding site [chemical binding]; other site 755731001942 Q-loop/lid; other site 755731001943 ABC transporter signature motif; other site 755731001944 Walker B; other site 755731001945 D-loop; other site 755731001946 H-loop/switch region; other site 755731001947 isoaspartyl dipeptidase; Provisional; Region: PRK10657 755731001948 Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281 755731001949 active site 755731001950 Peptidase family M48; Region: Peptidase_M48; pfam01435 755731001951 formate acetyltransferase 1; Region: pyr_form_ly_1; TIGR01255 755731001952 Pyruvate formate lyase 1; Region: PFL1; cd01678 755731001953 coenzyme A binding site [chemical binding]; other site 755731001954 active site 755731001955 catalytic residues [active] 755731001956 glycine loop; other site 755731001957 pyruvate formate-lyase 1-activating enzyme; Region: PFLA; TIGR02493 755731001958 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 755731001959 FeS/SAM binding site; other site 755731001960 PaaI_thioesterase is a tetrameric acyl-CoA thioesterase with a hot dog fold and one of several proteins responsible for phenylacetic acid (PA) degradation in bacteria. Although orthologs of PaaI exist in archaea and eukaryotes, their function has not...; Region: PaaI_thioesterase; cd03443 755731001961 CoenzymeA binding site [chemical binding]; other site 755731001962 subunit interaction site [polypeptide binding]; other site 755731001963 PHB binding site; other site 755731001964 Putative glucoamylase; Region: Glycoamylase; pfam10091 755731001965 Second GH94N domain of cyclic beta 1-2 glucan synthetase and similar domains; Region: GH94N_ChvB_NdvB_2_like; cd11753 755731001966 Cellobiose phosphorylase [Carbohydrate transport and metabolism]; Region: COG3459 755731001967 First GH94N domain of cyclic beta 1-2 glucan synthetase and similar domains; Region: GH94N_ChvB_NdvB_1_like; cd11756 755731001968 Protein of unknown function, DUF608; Region: DUF608; pfam04685 755731001969 isocitrate dehydrogenase; Validated; Region: PRK08299 755731001970 Asparagine synthetase (aspartate-ammonia ligase) (AsnA) catalyses the conversion of L-aspartate to L-asparagine in the presence of ATP and ammonia. AsnA is a homodimeric enzyme which is structurally similiar to the catalytic core domain of class II...; Region: AsnA; cd00645 755731001971 dimer interface [polypeptide binding]; other site 755731001972 active site 755731001973 asparaginyl-tRNA synthetase; Validated; Region: asnC; PRK03932 755731001974 EcAsnRS_like_N: N-terminal, anticodon recognition domain of the type found in Escherichia coli asparaginyl-tRNA synthetase (AsnRS) and, in Arabidopsis thaliana and Saccharomyces cerevisiae mitochondrial (mt) AsnRS. This domain is a beta-barrel domain (OB...; Region: EcAsnRS_like_N; cd04318 755731001975 putative dimer interface [polypeptide binding]; other site 755731001976 putative anticodon binding site; other site 755731001977 Asx tRNA synthetase (AspRS/AsnRS) class II core domain. Assignment to class II aminoacyl-tRNA synthetases (aaRS) based upon its structure and the presence of three characteristic sequence motifs in the core domain. This family includes AsnRS as well as...; Region: AsxRS_core; cd00776 755731001978 homodimer interface [polypeptide binding]; other site 755731001979 motif 1; other site 755731001980 motif 2; other site 755731001981 active site 755731001982 motif 3; other site 755731001983 Domain of unknown function (DUF4397); Region: DUF4397; pfam14344 755731001984 Domain of unknown function (DUF4397); Region: DUF4397; pfam14344 755731001985 hypothetical protein; Provisional; Region: PRK05590 755731001986 Citrate synthase (CS) catalyzes the condensation of acetyl coenzyme A (AcCoA) and oxalacetate (OAA) to form citrate and coenzyme A (CoA), the first step in the oxidative citric acid cycle (TCA or Krebs cycle). Peroxisomal CS is involved in the glyoxylate...; Region: citrate_synt_like_1_2; cd06113 755731001987 dimer interface [polypeptide binding]; other site 755731001988 Citrate synthase; Region: Citrate_synt; pfam00285 755731001989 active site 755731001990 citrylCoA binding site [chemical binding]; other site 755731001991 oxalacetate/citrate binding site [chemical binding]; other site 755731001992 coenzyme A binding site [chemical binding]; other site 755731001993 catalytic triad [active] 755731001994 solute carrier 6 subfamily, Fusobacterium nucleatum Tyt1-like; solute-binding domain; Region: SLC6sbd_Tyt1-Like; cd10336 755731001995 Na2 binding site [ion binding]; other site 755731001996 putative substrate binding site 1 [chemical binding]; other site 755731001997 Na binding site 1 [ion binding]; other site 755731001998 putative substrate binding site 2 [chemical binding]; other site 755731001999 pyruvate kinase; Provisional; Region: PRK06354 755731002000 Pyruvate kinase (PK): Large allosteric enzyme that regulates glycolysis through binding of the substrate, phosphoenolpyruvate, and one or more allosteric effectors. Like other allosteric enzymes, PK has a high substrate affinity R state and a low...; Region: Pyruvate_Kinase; cl17342 755731002001 domain interfaces; other site 755731002002 active site 755731002003 Phosphohistidine swiveling domain [Signal transduction mechanisms]; Region: COG3848 755731002004 ATP-dependent Lon protease, bacterial type [Posttranslational modification, protein turnover, chaperones]; Region: Lon; COG0466 755731002005 Found in ATP-dependent protease La (LON); Region: LON; smart00464 755731002006 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 755731002007 Walker A motif; other site 755731002008 ATP binding site [chemical binding]; other site 755731002009 Walker B motif; other site 755731002010 arginine finger; other site 755731002011 Lon protease (S16) C-terminal proteolytic domain; Region: Lon_C; pfam05362 755731002012 PRC-barrel domain containing protein [General function prediction only]; Region: COG3881 755731002013 Negative regulator of genetic competence (MecA); Region: MecA; pfam05389 755731002014 Maf-like protein; Region: Maf; pfam02545 755731002015 Nucleotide binding protein Maf. Maf has been implicated in inhibition of septum formation in eukaryotes, bacteria and archaea, but homologs in B.subtilis and S.cerevisiae are nonessential for cell division. Maf has been predicted to be a nucleotide- or...; Region: Maf; cd00555 755731002016 active site 755731002017 dimer interface [polypeptide binding]; other site 755731002018 hypothetical protein; Reviewed; Region: PRK00024 755731002019 endonuclease III; includes endonuclease III (DNA-(apurinic or apyrimidinic site) lyase), alkylbase DNA glycosidases (Alka-family) and other DNA glycosidases; Region: ENDO3c; cl14786 755731002020 Mov34/MPN/PAD-1 family; Region: MPN_DUF2466; cd08071 755731002021 MPN+ (JAMM) motif; other site 755731002022 Zinc-binding site [ion binding]; other site 755731002023 rod shape-determining protein MreB; Provisional; Region: PRK13927 755731002024 MreB and similar proteins; Region: MreB_like; cd10225 755731002025 nucleotide binding site [chemical binding]; other site 755731002026 Mg binding site [ion binding]; other site 755731002027 putative protofilament interaction site [polypeptide binding]; other site 755731002028 RodZ interaction site [polypeptide binding]; other site 755731002029 rod shape-determining protein MreC; Provisional; Region: PRK13922 755731002030 Protein of unknown function (DUF904); Region: DUF904; cl11531 755731002031 rod shape-determining protein MreC; Region: MreC; pfam04085 755731002032 Cell division protein FtsI/penicillin-binding protein 2 [Cell envelope biogenesis, outer membrane]; Region: FtsI; COG0768 755731002033 Penicillin-binding Protein dimerisation domain; Region: PBP_dimer; pfam03717 755731002034 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; pfam00905 755731002035 septum formation inhibitor; Reviewed; Region: minC; PRK00513 755731002036 Septum formation inhibitor MinC, N-terminal domain; Region: MinC_N; pfam05209 755731002037 Septum formation inhibitor MinC, C-terminal domain; Region: MinC_C; pfam03775 755731002038 Bacterial cell division requires the formation of a septum at mid-cell. The site is determined by the min operon products MinC, MinD and MinE. MinC is a nonspecific inhibitor of the septum protein FtsZ. MinE is the supressor of MinC. MinD plays a pivotal...; Region: MinD; cd02036 755731002039 CobQ/CobB/MinD/ParA nucleotide binding domain; Region: CbiA; pfam01656 755731002040 Switch I; other site 755731002041 Switch II; other site 755731002042 Septum formation topological specificity factor MinE; Region: MinE; cl00538 755731002043 MGS-like domain. This domain composes the whole protein of methylglyoxal synthetase, which catalyzes the enolization of dihydroxyacetone phosphate (DHAP) to produce methylglyoxal. The family also includes the C-terminal domain in carbamoyl phosphate...; Region: MGS-like; cl00245 755731002044 substrate binding site [chemical binding]; other site 755731002045 Membrane proteins related to metalloendopeptidases [Cell envelope biogenesis, outer membrane]; Region: NlpD; COG0739 755731002046 Peptidase family M23; Region: Peptidase_M23; pfam01551 755731002047 SpoIVFB Site-2 protease (S2P), a zinc metalloprotease (MEROPS family M50B), regulates intramembrane proteolysis (RIP), and is involved in the pro-sigmaK pathway of bacterial spore formation. SpoIVFB (sporulation protein, stage IV cell wall formation, F...; Region: S2P-M50_SpoIVFB; cd06161 755731002048 active site 755731002049 Peptidase family M50; Region: Peptidase_M50; pfam02163 755731002050 putative substrate binding region [chemical binding]; other site 755731002051 ferredoxin-NADP(+) reductase subunit alpha; Reviewed; Region: PRK06222 755731002052 FAD/NAD binding domain in the electron transfer subunit of dihydroorotate dehydrogenase-like proteins. Dihydroorotate dehydrogenases (DHODs) catalyze the only redox reaction in pyrimidine de novo biosynthesis. They catalyze the oxidation of (S)...; Region: DHOD_e_trans_like1; cd06219 755731002053 FAD binding pocket [chemical binding]; other site 755731002054 FAD binding motif [chemical binding]; other site 755731002055 phosphate binding motif [ion binding]; other site 755731002056 beta-alpha-beta structure motif; other site 755731002057 NAD binding pocket [chemical binding]; other site 755731002058 Iron coordination center [ion binding]; other site 755731002059 putative oxidoreductase; Provisional; Region: PRK12831 755731002060 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450 755731002061 flavodoxin; Provisional; Region: PRK06242 755731002062 Bacillus subtilis YkuE and related proteins, C-terminal metallophosphatase domain; Region: MPP_YkuE_C; cd07385 755731002063 Calcineurin-like phosphoesterase; Region: Metallophos; pfam00149 755731002064 putative active site [active] 755731002065 putative metal binding site [ion binding]; other site 755731002066 Predicted permease, member of the PurR regulon [General function prediction only]; Region: yhhT; COG0628 755731002067 Domain of unknown function DUF20; Region: UPF0118; pfam01594 755731002068 D-ala-D-ala dipeptidase; Region: Peptidase_M15; cl00813 755731002069 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3786 755731002070 Sulfite exporter TauE/SafE; Region: TauE; pfam01925 755731002071 Sulfite exporter TauE/SafE; Region: TauE; pfam01925 755731002072 MoxR-like ATPases [General function prediction only]; Region: COG0714 755731002073 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 755731002074 Walker A motif; other site 755731002075 ATP binding site [chemical binding]; other site 755731002076 Walker B motif; other site 755731002077 arginine finger; other site 755731002078 Uncharacterized conserved protein (some members contain a von Willebrand factor type A (vWA) domain) [General function prediction only]; Region: COG1721 755731002079 Protein of unknown function DUF58; Region: DUF58; pfam01882 755731002080 Domain of unknown function (DUF4129); Region: DUF4129; pfam13559 755731002081 Predicted transcriptional regulators [Transcription]; Region: COG1378 755731002082 Sugar-specific transcriptional regulator TrmB; Region: TrmB; cl17775 755731002083 Middle phospholipase D-like domain of the transcriptional regulator TrmB and similar proteins; Region: PLDc_like_TrmB_middle; cd09124 755731002084 C-terminal domain interface [polypeptide binding]; other site 755731002085 sugar binding site [chemical binding]; other site 755731002086 diaminopimelate decarboxylase; Region: lysA; TIGR01048 755731002087 Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzyme Diaminopimelate Decarboxylase; Region: PLPDE_III_DapDC; cd06828 755731002088 active site 755731002089 pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site 755731002090 substrate binding site [chemical binding]; other site 755731002091 catalytic residues [active] 755731002092 dimer interface [polypeptide binding]; other site 755731002093 diaminopimelate dehydrogenase; Region: DAP-DH; TIGR01921 755731002094 Dihydrodipicolinate reductase, N-terminus; Region: DapB_N; pfam01113 755731002095 Ricin-type beta-trefoil; Carbohydrate-binding domain formed from presumed gene triplication. The domain is found in a variety of molecules serving diverse functions such as enzymatic activity, inhibitory toxicity and signal transduction. Highly specific...; Region: RICIN; cd00161 755731002096 Ricin-type beta-trefoil lectin domain; Region: Ricin_B_lectin; pfam00652 755731002097 putative sugar binding sites [chemical binding]; other site 755731002098 Q-X-W motif; other site 755731002099 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3666 755731002100 Transposase DDE domain; Region: DDE_Tnp_1_6; pfam13751 755731002101 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 755731002102 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 755731002103 putative substrate translocation pore; other site 755731002104 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 755731002105 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 755731002106 Zinc peptidases M18, M20, M28, and M42; Region: Zinc_peptidase_like; cl14876 755731002107 Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer); Region: MA; smart00283 755731002108 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 755731002109 dimer interface [polypeptide binding]; other site 755731002110 putative CheW interface [polypeptide binding]; other site 755731002111 Beta-lactamase class C and other penicillin binding proteins [Defense mechanisms]; Region: AmpC; COG1680 755731002112 Beta-lactamase; Region: Beta-lactamase; pfam00144 755731002113 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 755731002114 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 755731002115 DNA binding residues [nucleotide binding] 755731002116 dimerization interface [polypeptide binding]; other site 755731002117 ABC-type uncharacterized transport system, ATPase component [General function prediction only]; Region: COG4586 755731002118 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 755731002119 Walker A/P-loop; other site 755731002120 ATP binding site [chemical binding]; other site 755731002121 Q-loop/lid; other site 755731002122 ABC transporter signature motif; other site 755731002123 Walker B; other site 755731002124 D-loop; other site 755731002125 H-loop/switch region; other site 755731002126 Domain of unknown function (DUF4162); Region: DUF4162; pfam13732 755731002127 ABC-type uncharacterized transport system, permease component [General function prediction only]; Region: COG4587 755731002128 ABC-2 family transporter protein; Region: ABC2_membrane_6; cl01496 755731002129 ABC-2 family transporter protein; Region: ABC2_membrane_6; cl01496 755731002130 5'-nucleotidase/2',3'-cyclic phosphodiesterase and related esterases [Nucleotide transport and metabolism]; Region: UshA; COG0737 755731002131 Escherichia coli UshA-like family, N-terminal metallophosphatase domain; Region: MPP_UshA_N_like; cd00845 755731002132 active site 755731002133 metal binding site [ion binding]; metal-binding site 755731002134 5'-nucleotidase, C-terminal domain; Region: 5_nucleotid_C; pfam02872 755731002135 Acyl carrier protein [Lipid metabolism / Secondary metabolites biosynthesis, transport, and catabolism]; Region: AcpP; COG0236 755731002136 A predicted NlpC/p60-like peptidase; Region: BtrH; pfam14399 755731002137 Peptidase family C39 mostly contains bacteriocin-processing endopeptidases from bacteria. The cysteine peptidases in family C39 cleave the "double-glycine" leader peptides from the precursors of various bacteriocins (mostly non-lantibiotic); Region: Peptidase_C39_like; cl00296 755731002138 Acyl-CoA synthetases (AMP-forming)/AMP-acid ligases II [Lipid metabolism / Secondary metabolites biosynthesis, transport, and catabolism]; Region: CaiC; COG0318 755731002139 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 755731002140 acyl-activating enzyme (AAE) consensus motif; other site 755731002141 AMP binding site [chemical binding]; other site 755731002142 active site 755731002143 CoA binding site [chemical binding]; other site 755731002144 diacylglycerol glucosyltransferase; Provisional; Region: PRK13609 755731002145 Thymidylate kinase [Nucleotide transport and metabolism]; Region: Tmk; COG0125 755731002146 Nucleoside/nucleotide kinase (NK) is a protein superfamily consisting of multiple families of enzymes that share structural similarity and are functionally related to the catalysis of the reversible phosphate group transfer from nucleoside triphosphates...; Region: NK; cl17190 755731002147 active site 755731002148 A predicted NlpC/p60-like peptidase; Region: BtrH; pfam14399 755731002149 Peptidase family C39 mostly contains bacteriocin-processing endopeptidases from bacteria. The cysteine peptidases in family C39 cleave the "double-glycine" leader peptides from the precursors of various bacteriocins (mostly non-lantibiotic); Region: Peptidase_C39_like; cl00296 755731002150 putative active site [active] 755731002151 Thioesterase domain; Region: Thioesterase; pfam00975 755731002152 pyridoxal-dependent decarboxylase, exosortase A system-associated; Region: dCO2ase_PEP1; TIGR03099 755731002153 Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzyme Btrk Decarboxylase; Region: PLPDE_III_Btrk_like; cd06839 755731002154 dimer interface [polypeptide binding]; other site 755731002155 active site 755731002156 pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site 755731002157 catalytic residues [active] 755731002158 substrate binding site [chemical binding]; other site 755731002159 ATP-grasp domain; Region: ATP-grasp_4; cl17255 755731002160 Phosphopantetheine attachment site; Region: PP-binding; cl09936 755731002161 CYTH-like (also known as triphosphate tunnel metalloenzyme (TTM)-like) Phosphatases; Region: CYTH-like_Pase; cl11964 755731002162 putative active site; other site 755731002163 putative triphosphate binding site [ion binding]; other site 755731002164 putative metal binding residues [ion binding]; other site 755731002165 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 755731002166 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 755731002167 metal binding site [ion binding]; metal-binding site 755731002168 active site 755731002169 I-site; other site 755731002170 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 755731002171 Zn2+ binding site [ion binding]; other site 755731002172 Mg2+ binding site [ion binding]; other site 755731002173 Domain of unknown function (DUF2935); Region: DUF2935; pfam11155 755731002174 Domain of unknown function (DUF2935); Region: DUF2935; pfam11155 755731002175 Predicted oxidoreductases of the aldo/keto reductase family [General function prediction only]; Region: COG1453 755731002176 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 755731002177 active site 755731002178 catalytic tetrad [active] 755731002179 The HCP family of iron-sulfur proteins includes hybrid cluster protein (HCP), acetyl-CoA synthase (ACS), and carbon monoxide dehydrogenase (CODH), all of which contain [Fe4-S4] metal clusters at their active sites. These proteins have a conserved...; Region: HCP_like; cl14655 755731002180 conserved hypothetical integral membrane protein; Region: TIGR03766 755731002181 Benzoyl-CoA reductase/2-hydroxyglutaryl-CoA dehydratase subunit, BcrC/BadD/HgdB [Amino acid transport and metabolism]; Region: HgdB; COG1775 755731002182 BadF/BadG/BcrA/BcrD ATPase family; Region: BcrAD_BadFG; cl17271 755731002183 small acid-soluble spore protein Tlp; Provisional; Region: PRK03830 755731002184 uncharacterized bacterial and archaeal solute carrier 6 subfamily; solute-binding domain; Region: SLC6sbd_u1; cd10334 755731002185 Na2 binding site [ion binding]; other site 755731002186 putative substrate binding site 1 [chemical binding]; other site 755731002187 Na binding site 1 [ion binding]; other site 755731002188 putative substrate binding site 2 [chemical binding]; other site 755731002189 Putative lysophospholipase; Region: Hydrolase_4; pfam12146 755731002190 Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596 755731002191 TAP-like protein; Region: Abhydrolase_4; pfam08386 755731002192 Hemerythrin-like domain; Region: Hr-like; cd12108 755731002193 Fe binding site [ion binding]; other site 755731002194 Nitroreductase-like family 4. A subfamily of the nitroreductase family containing uncharacterized proteins that are similar to nitroreductase. Nitroreductase catalyzes the reduction of nitroaromatic compounds such as nitrotoluenes, nitrofurans and...; Region: Nitroreductase_4; cd02140 755731002195 dimer interface [polypeptide binding]; other site 755731002196 FMN binding site [chemical binding]; other site 755731002197 Phage Tail Collar Domain; Region: Collar; pfam07484 755731002198 Phage Tail Collar Domain; Region: Collar; pfam07484 755731002199 Phage Tail Collar Domain; Region: Collar; pfam07484 755731002200 Cadherin-like beta sandwich domain; Region: Cadherin-like; pfam12733 755731002201 Cadherin-like beta sandwich domain; Region: Cadherin-like; pfam12733 755731002202 Cadherin-like beta sandwich domain; Region: Cadherin-like; pfam12733 755731002203 Calx-beta domain; Region: Calx-beta; pfam03160 755731002204 Calx-beta domain; Region: Calx-beta; pfam03160 755731002205 Calx-beta domain; Region: Calx-beta; pfam03160 755731002206 Calx-beta domain; Region: Calx-beta; cl02522 755731002207 Calx-beta domain; Region: Calx-beta; pfam03160 755731002208 S-layer homology domain; Region: SLH; pfam00395 755731002209 S-layer homology domain; Region: SLH; pfam00395 755731002210 Zinc metalloprotease (elastase) [Amino acid transport and metabolism]; Region: LasB; COG3227 755731002211 Fungalysin/Thermolysin Propeptide Motif; Region: FTP; pfam07504 755731002212 Peptidase M4 family includes thermolysin, protealysin, aureolysin and neutral protease; Region: M4_neutral_protease; cd09597 755731002213 active site 755731002214 Zn binding site [ion binding]; other site 755731002215 Superfamily II DNA and RNA helicases [DNA replication, recombination, and repair / Transcription / Translation, ribosomal structure and biogenesis]; Region: SrmB; COG0513 755731002216 DEAD-box helicases. A diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker B motif; Region: DEADc; cd00268 755731002217 ATP binding site [chemical binding]; other site 755731002218 Mg++ binding site [ion binding]; other site 755731002219 motif III; other site 755731002220 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 755731002221 nucleotide binding region [chemical binding]; other site 755731002222 ATP-binding site [chemical binding]; other site 755731002223 RNA recognition motif in the DbpA subfamily of prokaryotic DEAD-box rRNA helicases; Region: RRM_DbpA; cd12252 755731002224 RNA binding site [nucleotide binding]; other site 755731002225 haloacid dehalogenase-like hydrolase; Region: HAD; cl17202 755731002226 haloacid dehalogenase-like hydrolase; Region: Hydrolase; pfam00702 755731002227 Glycerol dehydrogenase and related enzymes [Energy production and conversion]; Region: GldA; COG0371 755731002228 Dehydroquinate synthase-like (DHQ-like) and iron-containing alcohol dehydrogenases (Fe-ADH); Region: DHQ_Fe-ADH; cl02872 755731002229 active site 755731002230 NAD binding site [chemical binding]; other site 755731002231 metal binding site [ion binding]; metal-binding site 755731002232 L-lactate dehydrogenase; Reviewed; Region: ldh; PRK00066 755731002233 A subgroup of L-lactate dehydrogenases; Region: LDH_2; cd05292 755731002234 NAD binding site [chemical binding]; other site 755731002235 dimer interface [polypeptide binding]; other site 755731002236 substrate binding site [chemical binding]; other site 755731002237 tetramer (dimer of dimers) interface [polypeptide binding]; other site 755731002238 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 755731002239 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 755731002240 metal binding site [ion binding]; metal-binding site 755731002241 active site 755731002242 I-site; other site 755731002243 Hemerythrin; Region: Hemerythrin; cd12107 755731002244 Fe binding site [ion binding]; other site 755731002245 coenzyme A disulfide reductase; Reviewed; Region: PRK09564 755731002246 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500 755731002247 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 755731002248 Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain; Region: Pyr_redox_dim; pfam02852 755731002249 Major Facilitator Superfamily; Region: MFS_1; pfam07690 755731002250 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 755731002251 putative substrate translocation pore; other site 755731002252 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 755731002253 Predicted phosphatases [General function prediction only]; Region: Gph; COG0546 755731002254 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 755731002255 active site 755731002256 motif I; other site 755731002257 motif II; other site 755731002258 stage V sporulation protein B; Region: spore_V_B; TIGR02900 755731002259 Stage V sporulation protein B, also known as Stage III sporulation protein F, and related proteins; Region: MATE_SpoVB_like; cd13124 755731002260 Protein of unknown function (DUF1294); Region: DUF1294; pfam06961 755731002261 FOG: FHA domain [Signal transduction mechanisms]; Region: COG1716 755731002262 Forkhead associated domain (FHA); found in eukaryotic and prokaryotic proteins. Putative nuclear signalling domain. FHA domains may bind phosphothreonine, phosphoserine and sometimes phosphotyrosine. In eukaryotes, many FHA domain-containing proteins...; Region: FHA; cd00060 755731002263 phosphopeptide binding site; other site 755731002264 Bacterial cell division membrane protein [Cell division and chromosome partitioning]; Region: FtsW; COG0772 755731002265 Cell division protein FtsI/penicillin-binding protein 2 [Cell envelope biogenesis, outer membrane]; Region: FtsI; COG0768 755731002266 Penicillin-binding Protein dimerisation domain; Region: PBP_dimer; pfam03717 755731002267 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; pfam00905 755731002268 Putative motility protein; Region: YjfB_motility; pfam14070 755731002269 bifunctional homocysteine S-methyltransferase/5,10-methylenetetrahydrofolate reductase protein; Reviewed; Region: PRK08645 755731002270 Methionine synthase I (cobalamin-dependent), methyltransferase domain [Amino acid transport and metabolism]; Region: MetH; cl14105 755731002271 Methylenetetrahydrofolate reductase (MTHFR). 5,10-Methylenetetrahydrofolate is reduced to 5-methyltetrahydrofolate by methylenetetrahydrofolate reductase, a cytoplasmic, NAD(P)-dependent enzyme. 5-methyltetrahydrofolate is utilized by methionine synthase...; Region: MTHFR; cd00537 755731002272 FAD binding site [chemical binding]; other site 755731002273 Pterin binding enzymes. This family includes dihydropteroate synthase (DHPS) and cobalamin-dependent methyltransferases such as methyltetrahydrofolate, corrinoid iron-sulfur protein methyltransferase (MeTr) and methionine synthase (MetH). DHPS, a...; Region: Pterin_binding; cl00219 755731002274 Methionine synthase I, cobalamin-binding domain [Amino acid transport and metabolism]; Region: MetH; COG1410 755731002275 substrate binding pocket [chemical binding]; other site 755731002276 dimer interface [polypeptide binding]; other site 755731002277 inhibitor binding site; inhibition site 755731002278 Long-chain acyl-CoA synthetases (AMP-forming) [Lipid metabolism]; Region: FAA1; COG1022 755731002279 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 755731002280 Long-chain fatty acid CoA synthetases and Bubblegum-like very long-chain fatty acid CoA synthetases; Region: VL_LC_FACS_like; cd05907 755731002281 acyl-activating enzyme (AAE) consensus motif; other site 755731002282 putative active site [active] 755731002283 putative AMP binding site [chemical binding]; other site 755731002284 putative CoA binding site [chemical binding]; other site 755731002285 Archaeal fructose-1,6-bisphosphatase and related enzymes of inositol monophosphatase family [Carbohydrate transport and metabolism]; Region: SuhB; COG0483 755731002286 IMPase, inositol monophosphatase and related domains. A family of Mg++ dependent phosphatases, inhibited by lithium, many of which may act on inositol monophosphate substrate. They dephosphorylate inositol phosphate to generate inositol, which may be...; Region: IMPase; cd01639 755731002287 active site 755731002288 dimerization interface [polypeptide binding]; other site 755731002289 Cys-rich peptide radical SAM maturase CcpM; Region: rSAM_ocin_clost; TIGR04068 755731002290 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 755731002291 FeS/SAM binding site; other site 755731002292 Domain of unknown function (DUF4008); Region: DUF4008; cl14869 755731002293 peptide maturation system protein, TIGR04066 family; Region: nat_prod_clost 755731002294 peptide maturation system acyl carrier-related protein; Region: ocin_ACP_rel; TIGR04069 755731002295 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 755731002296 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 755731002297 active site 755731002298 phosphorylation site [posttranslational modification] 755731002299 intermolecular recognition site; other site 755731002300 dimerization interface [polypeptide binding]; other site 755731002301 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 755731002302 DNA binding residues [nucleotide binding] 755731002303 dimerization interface [polypeptide binding]; other site 755731002304 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 755731002305 Syntaxin N-terminus domain; syntaxins are nervous system-specific proteins implicated in the docking of synaptic vesicles with the presynaptic plasma membrane; they are a family of receptors for intracellular transport vesicles; each target membrane may...; Region: SynN; cl00143 755731002306 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 755731002307 ATP binding site [chemical binding]; other site 755731002308 Mg2+ binding site [ion binding]; other site 755731002309 G-X-G motif; other site 755731002310 Mismatch repair ATPase (MutS family) [DNA replication, recombination, and repair]; Region: MutS; COG0249 755731002311 MutS domain III; Region: MutS_III; pfam05192 755731002312 ATP-binding cassette domain of MutS-like homolog; Region: ABC_MutS-like; cd03283 755731002313 Walker A/P-loop; other site 755731002314 ATP binding site [chemical binding]; other site 755731002315 Q-loop/lid; other site 755731002316 ABC transporter signature motif; other site 755731002317 Walker B; other site 755731002318 D-loop; other site 755731002319 H-loop/switch region; other site 755731002320 Respiratory-chain NADH dehydrogenase 24 Kd subunit; Region: Complex1_24kDa; pfam01257 755731002321 TRX-like [2Fe-2S] Ferredoxin (Fd) family, NADH:ubiquinone oxidoreductase (Nuo) subunit E subfamily; Nuo, also called respiratory chain Complex 1, is the entry point for electrons into the respiratory chains of bacteria and the mitochondria of eukaryotes; Region: TRX_Fd_NuoE; cd03064 755731002322 putative dimer interface [polypeptide binding]; other site 755731002323 [2Fe-2S] cluster binding site [ion binding]; other site 755731002324 NADH:ubiquinone oxidoreductase, NADH-binding (51 kD) subunit [Energy production and conversion]; Region: NuoF; COG1894 755731002325 SLBB domain; Region: SLBB; pfam10531 755731002326 NADH-ubiquinone oxidoreductase-F iron-sulfur binding region; Region: NADH_4Fe-4S; pfam10589 755731002327 bidirectional hydrogenase complex protein HoxU; Validated; Region: PRK07569 755731002328 2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207 755731002329 catalytic loop [active] 755731002330 iron binding site [ion binding]; other site 755731002331 NADH-ubiquinone oxidoreductase-G iron-sulfur binding region; Region: NADH-G_4Fe-4S_3; pfam10588 755731002332 [FeFe] hydrogenase, group A; Region: FeFe_hydrog_A; TIGR02512 755731002333 4Fe-4S binding domain; Region: Fer4; pfam00037 755731002334 Iron only hydrogenase large subunit, C-terminal domain; Region: Fe_hyd_lg_C; pfam02906 755731002335 Iron hydrogenase small subunit; Region: Fe_hyd_SSU; pfam02256 755731002336 Cation transporter/ATPase, N-terminus; Region: Cation_ATPase_N; pfam00690 755731002337 Cation transport ATPase [Inorganic ion transport and metabolism]; Region: MgtA; COG0474 755731002338 E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122 755731002339 Putative hydrolase of sodium-potassium ATPase alpha subunit; Region: Hydrolase_like2; pfam13246 755731002340 haloacid dehalogenase-like hydrolase; Region: HAD; pfam12710 755731002341 Cation transporting ATPase, C-terminus; Region: Cation_ATPase_C; pfam00689 755731002342 outer membrane assembly lipoprotein YfgL; Region: assembly_YfgL; TIGR03300 755731002343 PQQ-dependent dehydrogenases and related proteins; Region: PQQ_DH_like; cl11493 755731002344 PQQ-dependent dehydrogenases and related proteins; Region: PQQ_DH_like; cl11493 755731002345 active site 755731002346 Trp docking motif [polypeptide binding]; other site 755731002347 PQQ-like domain; Region: PQQ_2; pfam13360 755731002348 signal peptidase I, bacterial type; Region: sigpep_I_bact; TIGR02227 755731002349 The S26 Type I signal peptidase (SPase; LepB; leader peptidase B; leader peptidase I; EC 3.4.21.89) family members are essential membrane-bound serine proteases that function to cleave the amino-terminal signal peptide extension from proteins that are...; Region: S26_SPase_I; cd06530 755731002350 Catalytic site [active] 755731002351 Acyl-ACP thioesterase [Lipid metabolism]; Region: FatA; COG3884 755731002352 4-hydroxybenzoyl-CoA thioesterase (4HBT). Catalyzes the final step in the 4-chlorobenzoate degradation pathway in which 4-chlorobenzoate is converted to 4-hydroxybenzoate in certain soil-dwelling bacteria. 4HBT forms a homotetramer with four active sites; Region: 4HBT; cd00586 755731002353 active site 755731002354 Thioesterase-like superfamily; Region: 4HBT_2; pfam13279 755731002355 active site 2 [active] 755731002356 active site 1 [active] 755731002357 Sporulation and spore germination; Region: Germane; cl11253 755731002358 Uncharacterized conserved protein [Function unknown]; Region: COG1434 755731002359 YdcF-like. YdcF-like is a large family of mainly bacterial proteins, with a few members found in fungi, plants, and archaea. Escherichia coli YdcF has been shown to bind S-adenosyl-L-methionine (AdoMet), but a biochemical function has not been...; Region: YdcF-like; cd06259 755731002360 putative active site [active] 755731002361 ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653 755731002362 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; pfam01547 755731002363 ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395 755731002364 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 755731002365 dimer interface [polypeptide binding]; other site 755731002366 conserved gate region; other site 755731002367 putative PBP binding loops; other site 755731002368 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cl00427 755731002369 ABC-ATPase subunit interface; other site 755731002370 ABC-type polysaccharide transport system, permease component [Carbohydrate transport and metabolism]; Region: LplB; COG4209 755731002371 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 755731002372 dimer interface [polypeptide binding]; other site 755731002373 conserved gate region; other site 755731002374 ABC-ATPase subunit interface; other site 755731002375 putative alpha-glucosidase; Provisional; Region: PRK10658 755731002376 Galactose mutarotase-like; Region: Gal_mutarotas_2; pfam13802 755731002377 YicI alpha-xylosidase is a glycosyl hydrolase family 31 (GH31) enzyme that catalyzes the release of an alpha-xylosyl residue from the non-reducing end of alpha-xyloside substrates such as alpha-xylosyl fluoride and isoprimeverose. YicI forms a...; Region: GH31_xylosidase_YicI; cd06593 755731002378 active site 755731002379 homotrimer interface [polypeptide binding]; other site 755731002380 catalytic site [active] 755731002381 homohexamer (dimer of homotrimers) interface [polypeptide binding]; other site 755731002382 beta-D-glucoside glucohydrolase; Provisional; Region: PRK15098 755731002383 Glycosyl hydrolase family 3 N terminal domain; Region: Glyco_hydro_3; pfam00933 755731002384 Fibronectin type III-like domain; Region: Fn3-like; pfam14310 755731002385 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 755731002386 HAMP domain; Region: HAMP; pfam00672 755731002387 Histidine kinase; Region: His_kinase; pfam06580 755731002388 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 755731002389 ATP binding site [chemical binding]; other site 755731002390 Mg2+ binding site [ion binding]; other site 755731002391 G-X-G motif; other site 755731002392 Response regulator containing CheY-like receiver domain and AraC-type DNA-binding domain [Signal transduction mechanisms]; Region: COG4753 755731002393 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 755731002394 active site 755731002395 phosphorylation site [posttranslational modification] 755731002396 intermolecular recognition site; other site 755731002397 dimerization interface [polypeptide binding]; other site 755731002398 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 755731002399 Beta-galactosidase [Carbohydrate transport and metabolism]; Region: LacA; COG1874 755731002400 Beta-galactosidase; Region: Glyco_hydro_42; pfam02449 755731002401 A4 beta-galactosidase middle domain: a type 1 glutamine amidotransferase (GATase1)-like domain; Region: A4_beta-galactosidase_middle_domain; cd03143 755731002402 Beta-galactosidase C-terminal domain; Region: Glyco_hydro_42C; pfam08533 755731002403 Tryptophan synthase-beta: Trptophan synthase is a bifunctional enzyme that catalyses the last two steps in the biosynthesis of L-tryptophan via its alpha and beta reactions. In the alpha reaction, indole 3-glycerol phosphate is cleaved reversibly to...; Region: Trp-synth_B; cd06446 755731002404 Pyridoxal-phosphate dependent enzyme; Region: PALP; pfam00291 755731002405 pyridoxal 5'-phosphate binding site [chemical binding]; other site 755731002406 catalytic residue [active] 755731002407 Integral membrane protein (intg_mem_TP0381); Region: Intg_mem_TP0381; pfam09529 755731002408 putative aminophosphonate oxidoreductase; Region: Phn_aa_oxid; TIGR03329 755731002409 Glycine/D-amino acid oxidases (deaminating) [Amino acid transport and metabolism]; Region: DadA; COG0665 755731002410 Rieske Fe-S protein [Energy production and conversion]; Region: QcrA; COG0723 755731002411 YhfW family, C-terminal Rieske domain; YhfW is a protein of unknown function with an N-terminal DadA-like (glycine/D-amino acid dehydrogenase) domain and a C-terminal Rieske domain. The Rieske domain is a [2Fe-2S] cluster binding domain involved in...; Region: Rieske_YhfW_C; cd03477 755731002412 [2Fe-2S] cluster binding site [ion binding]; other site 755731002413 menaquinone biosynthesis decarboxylase, SCO4490 family; Region: mena_SCO4490; TIGR03701 755731002414 4-hydroxybenzoate polyprenyltransferase and related prenyltransferases [Coenzyme metabolism]; Region: UbiA; cl00337 755731002415 UbiA prenyltransferase family; Region: UbiA; pfam01040 755731002416 Predicted Zn-dependent peptidases, insulinase-like [General function prediction only]; Region: COG1026 755731002417 Insulinase (Peptidase family M16); Region: Peptidase_M16; pfam00675 755731002418 Peptidase M16 inactive domain; Region: Peptidase_M16_C; pfam05193 755731002419 Peptidase M16C associated; Region: M16C_assoc; pfam08367 755731002420 S-layer homology domain; Region: SLH; pfam00395 755731002421 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cl17432 755731002422 NMT1/THI5 like; Region: NMT1; pfam09084 755731002423 Nitrogen regulatory protein PII [Amino acid transport and metabolism]; Region: GlnK; COG0347 755731002424 Nitrogen regulatory protein P-II; Region: P-II; smart00938 755731002425 Ammonia permease [Inorganic ion transport and metabolism]; Region: AmtB; COG0004 755731002426 Membrane transporters of cations and cationic drugs [Inorganic ion transport and metabolism]; Region: EmrE; COG2076 755731002427 ykkC-yxkD leader; IMG reference gene:2509527564 755731002428 Kef-type K+ transport systems, membrane components [Inorganic ion transport and metabolism]; Region: KefB; COG0475 755731002429 Sodium/hydrogen exchanger family; Region: Na_H_Exchanger; pfam00999 755731002430 ABC-type nitrate/sulfonate/bicarbonate transport system, ATPase component [Inorganic ion transport and metabolism]; Region: TauB; COG1116 755731002431 ATP-binding cassette domain of the nitrate and sulfonate transporters; Region: ABC_NrtD_SsuB_transporters; cd03293 755731002432 Walker A/P-loop; other site 755731002433 ATP binding site [chemical binding]; other site 755731002434 Q-loop/lid; other site 755731002435 ABC transporter signature motif; other site 755731002436 Walker B; other site 755731002437 D-loop; other site 755731002438 H-loop/switch region; other site 755731002439 ABC-type nitrate/sulfonate/bicarbonate transport system, permease component [Inorganic ion transport and metabolism]; Region: TauC; COG0600 755731002440 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cl00427 755731002441 Major Facilitator Superfamily; Region: MFS_1; pfam07690 755731002442 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 755731002443 putative substrate translocation pore; other site 755731002444 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 755731002445 Major Facilitator Superfamily; Region: MFS_1; pfam07690 755731002446 putative substrate translocation pore; other site 755731002447 MarR family; Region: MarR; pfam01047 755731002448 Site-specific recombinases, DNA invertase Pin homologs [DNA replication, recombination, and repair]; Region: PinR; COG1961 755731002449 Serine Recombinase (SR) family, Resolvase and Invertase subfamily, catalytic domain; members contain a C-terminal DNA binding domain. Serine recombinases catalyze site-specific recombination of DNA molecules by a concerted, four-strand cleavage and...; Region: SR_ResInv; cd03768 755731002450 catalytic residues [active] 755731002451 catalytic nucleophile [active] 755731002452 Presynaptic Site I dimer interface [polypeptide binding]; other site 755731002453 Synaptic Antiparallel dimer interface [polypeptide binding]; other site 755731002454 Synaptic Flat tetramer interface [polypeptide binding]; other site 755731002455 Synaptic Site I dimer interface [polypeptide binding]; other site 755731002456 DNA binding site [nucleotide binding] 755731002457 Recombinase; Region: Recombinase; pfam07508 755731002458 Recombinase zinc beta ribbon domain; Region: Zn_ribbon_recom; pfam13408 755731002459 Glutamine amidotransferases class-II (GATase) asparagine synthase_B type. Asparagine synthetase B catalyses the ATP-dependent conversion of aspartate to asparagine. This enzyme is a homodimer, with each monomer composed of a glutaminase domain and a...; Region: AsnB; cd00712 755731002460 active site 755731002461 dimer interface [polypeptide binding]; other site 755731002462 Glutamine amidotransferase domain; Region: GATase_6; pfam13522 755731002463 The C-terminal domain of Asparagine Synthase B. This domain is always found associated n-terminal amidotransferase domain. Family members that contain this domain catalyse the conversion of aspartate to asparagine. Asparagine synthetase B catalyzes the...; Region: Asn_Synthase_B_C; cd01991 755731002464 Ligand Binding Site [chemical binding]; other site 755731002465 Molecular Tunnel; other site 755731002466 Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer); Region: MA; smart00283 755731002467 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 755731002468 dimer interface [polypeptide binding]; other site 755731002469 putative CheW interface [polypeptide binding]; other site 755731002470 Cache domain; Region: Cache_1; pfam02743 755731002471 Uncharacterized protein related to glutamine synthetase [General function prediction only]; Region: COG3968 755731002472 Glutamine synthetase type III N terminal; Region: GSIII_N; pfam12437 755731002473 Glutamine synthetase, catalytic domain; Region: Gln-synt_C; pfam00120 755731002474 aspartyl/glutamyl-tRNA amidotransferase subunit B; Validated; Region: gatB; PRK05477 755731002475 GatB/GatE catalytic domain; Region: GatB_N; pfam02934 755731002476 GatB domain; Region: GatB_Yqey; smart00845 755731002477 Asp-tRNAAsn/Glu-tRNAGln amidotransferase A subunit and related amidases [Translation, ribosomal structure and biogenesis]; Region: GatA; COG0154 755731002478 aspartyl/glutamyl-tRNA amidotransferase subunit A; Reviewed; Region: gatA; PRK00012 755731002479 aspartyl/glutamyl-tRNA amidotransferase subunit C; Reviewed; Region: gatC; PRK00034 755731002480 Glutamate synthase domain 1 [Amino acid transport and metabolism]; Region: GltB; COG0067 755731002481 Glutamine amidotransferases class-II (GATase). The glutaminase domain catalyzes an amide nitrogen transfer from glutamine to the appropriate substrate. In this process, glutamine is hydrolyzed to glutamic acid and ammonia. This domain is related to...; Region: Gn_AT_II; cl00319 755731002482 Glutamine amidotransferases class-II (Gn-AT)_GlxB-type. GlxB is a glutamine amidotransferase-like protein of unknown function found in bacteria and archaea. GlxB has a structural fold similar to that of other class II glutamine amidotransferases...; Region: GlxB; cd01907 755731002483 putative active site [active] 755731002484 4Fe-4S dicluster domain; Region: Fer4_10; pfam13237 755731002485 Glutamate synthase domain 2 [Amino acid transport and metabolism]; Region: GltB; COG0069 755731002486 Glutamate synthase (GltS) FMN-binding domain. GltS is a complex iron-sulfur flavoprotein that catalyzes the reductive synthesis of L-glutamate from 2-oxoglutarate and L-glutamine via intramolecular channelling of ammonia, a reaction in the plant, yeast...; Region: GltS_FMN; cd02808 755731002487 active site 755731002488 FMN binding site [chemical binding]; other site 755731002489 substrate binding site [chemical binding]; other site 755731002490 3Fe-4S cluster binding site [ion binding]; other site 755731002491 4Fe-4S dicluster domain; Region: Fer4_7; pfam12838 755731002492 Uncharacterized NAD(FAD)-dependent dehydrogenases [General function prediction only]; Region: HcaD; COG0446 755731002493 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500 755731002494 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 755731002495 GXGXG domain. This domain of unknown function is found at the C-terminus of the large subunit (gltB) of glutamate synthase (GltS), in subunit C of tungsten formylmethanofuran dehydrogenase (FwdC) and in subunit C of molybdenum formylmethanofuran...; Region: GXGXG; cl00239 755731002496 domain_subunit interface; other site 755731002497 Glutamine synthetase [Amino acid transport and metabolism]; Region: GlnA; COG0174 755731002498 Glutamine synthetase, beta-Grasp domain; Region: Gln-synt_N; pfam03951 755731002499 Glutamine synthetase, catalytic domain; Region: Gln-synt_C; pfam00120 755731002500 ANTAR domain; Region: ANTAR; pfam03861 755731002501 Ammonia permease [Inorganic ion transport and metabolism]; Region: AmtB; COG0004 755731002502 Nitrogen regulatory protein PII [Amino acid transport and metabolism]; Region: GlnK; COG0347 755731002503 Nitrogen regulatory protein P-II; Region: P-II; smart00938 755731002504 agmatinase; Region: agmatinase; TIGR01230 755731002505 Agmatinase and related proteins; Region: Agmatinase-like_2; cd11593 755731002506 putative active site [active] 755731002507 Mn binding site [ion binding]; other site 755731002508 Class I aldolases; Region: Aldolase_Class_I; cl17187 755731002509 Predicted SAM-dependent methyltransferases [General function prediction only]; Region: COG1092 755731002510 Methyltransferase domain; Region: Methyltransf_26; pfam13659 755731002511 Pseudouridylate synthases, 23S RNA-specific [Translation, ribosomal structure and biogenesis]; Region: RluA; COG0564 755731002512 Pseudouridine synthase, RsuA/RluD family; Region: PseudoU_synth_RluCD_like; cd02869 755731002513 active site 755731002514 glutamate dehydrogenase; Provisional; Region: PRK09414 755731002515 Glu/Leu/Phe/Val dehydrogenase, dimerisation domain; Region: ELFV_dehydrog_N; pfam02812 755731002516 NAD(P) binding domain of amino acid dehydrogenase-like proteins; Region: NAD_bind_amino_acid_DH; cl17226 755731002517 NAD(P) binding pocket [chemical binding]; other site 755731002518 Predicted N6-adenine-specific DNA methylase [DNA replication, recombination, and repair]; Region: COG0116 755731002519 THUMP domain associated with S-adenosylmethionine-dependent methyltransferases; Region: THUMP_AdoMetMT; cd11715 755731002520 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl17173 755731002521 3-phosphoshikimate 1-carboxyvinyltransferase; Provisional; Region: PRK02427 755731002522 EPSP synthase domain. 3-phosphoshikimate 1-carboxyvinyltransferase (5-enolpyruvylshikimate-3-phosphate synthase) (EC 2.5.1.19) catalyses the reaction between shikimate-3-phosphate (S3P) and phosphoenolpyruvate (PEP) to form...; Region: EPSP_synthase; cd01556 755731002523 hinge; other site 755731002524 active site 755731002525 Chorismate synthase [Amino acid transport and metabolism]; Region: AroC; COG0082 755731002526 Chorismase synthase, the enzyme catalyzing the final step of the shikimate pathway; Region: Chorismate_synthase; cd07304 755731002527 Tetramer interface [polypeptide binding]; other site 755731002528 active site 755731002529 FMN-binding site [chemical binding]; other site 755731002530 shikimate kinase; Reviewed; Region: aroK; PRK00131 755731002531 Shikimate kinase (SK) is the fifth enzyme in the shikimate pathway, a seven-step biosynthetic pathway which converts erythrose-4-phosphate to chorismic acid, found in bacteria, fungi and plants. Chorismic acid is a important intermediate in the synthesis...; Region: SK; cd00464 755731002532 ADP binding site [chemical binding]; other site 755731002533 magnesium binding site [ion binding]; other site 755731002534 putative shikimate binding site; other site 755731002535 sporulation transcription factor Spo0A; Region: spore_0_A; TIGR02875 755731002536 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 755731002537 active site 755731002538 phosphorylation site [posttranslational modification] 755731002539 intermolecular recognition site; other site 755731002540 dimerization interface [polypeptide binding]; other site 755731002541 Sporulation initiation factor Spo0A C terminal; Region: Spo0A_C; pfam08769 755731002542 Integration host factor (IHF) and HU are small heterodimeric members of the DNABII protein family that bind and bend DNA, functioning as architectural factors in many cellular processes including transcription, site-specific recombination, and...; Region: HU_IHF; cd00591 755731002543 IHF - DNA interface [nucleotide binding]; other site 755731002544 IHF dimer interface [polypeptide binding]; other site 755731002545 USP domain is located between the N-terminal sensor domain and C-terminal catalytic domain of this Osmosensitive K+ channel histidine kinase family. The family of KdpD sensor kinase proteins regulates the kdpFABC operon responsible for potassium...; Region: USP_OKCHK; cd01987 755731002546 Ligand Binding Site [chemical binding]; other site 755731002547 fumarate hydratase; Provisional; Region: PRK06246 755731002548 Fumarase C-terminus; Region: Fumerase_C; cl00795 755731002549 hybrid cluster protein-associated redox disulfide domain; Region: prismane_assoc; TIGR03980 755731002550 Adenylosuccinate synthetase (AdSS) catalyzes the first step in the de novo biosynthesis of AMP. IMP and L-aspartate are conjugated in a two-step reaction accompanied by the hydrolysis of GTP to GDP in the presence of Mg2+. In the first step, the...; Region: AdSS; cd03108 755731002551 Adenylosuccinate synthetase; Region: Adenylsucc_synt; smart00788 755731002552 GDP-binding site [chemical binding]; other site 755731002553 ACT binding site; other site 755731002554 IMP binding site; other site 755731002555 Dolichyl-phosphate-mannose-protein mannosyltransferase; Region: PMT_2; cl17364 755731002556 diaminopimelate epimerase; Provisional; Region: dapF; PRK00450 755731002557 Diaminopimelate epimerase; Region: DAP_epimerase; pfam01678 755731002558 Diaminopimelate epimerase; Region: DAP_epimerase; pfam01678 755731002559 L,L-diaminopimelate aminotransferase; Validated; Region: PRK07590 755731002560 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 755731002561 pyridoxal 5'-phosphate binding site [chemical binding]; other site 755731002562 homodimer interface [polypeptide binding]; other site 755731002563 catalytic residue [active] 755731002564 Family 4 Uracil-DNA glycosylase (UDG), found exclusively in thermophilic organisms; Region: UDG_F4_TTUDGA_like; cd10030 755731002565 Fe-S cluster binding site [ion binding]; other site 755731002566 active site 755731002567 Family 4 Uracil-DNA glycosylase (UDG), found exclusively in thermophilic organisms; Region: UDG_F4_TTUDGA_like; cd10030 755731002568 active site 755731002569 Fe-S cluster binding site [ion binding]; other site 755731002570 Type II secretion system (T2SS), protein E, N-terminal domain; Region: T2SE_Nter; pfam05157 755731002571 Type II secretory pathway, ATPase PulE/Tfp pilus assembly pathway, ATPase PilB [Cell motility and secretion / Intracellular trafficking and secretion]; Region: PulE; COG2804 755731002572 PulE/GspE The type II secretory pathway is the main terminal branch of the general secretory pathway (GSP). It is responsible for the export the majority of Gram-negative bacterial exoenzymes and toxins. PulE is a cytoplasmic protein of the GSP, which...; Region: PulE-GspE; cd01129 755731002573 Walker A motif; other site 755731002574 ATP binding site [chemical binding]; other site 755731002575 Walker B motif; other site 755731002576 Tfp pilus assembly protein, pilus retraction ATPase PilT [Cell motility and secretion / Intracellular trafficking and secretion]; Region: PilT; COG2805 755731002577 RecA-like NTPases. This family includes the NTP binding domain of F1 and V1 H+ATPases, DnaB and related helicases as well as bacterial RecA and related eukaryotic and archaeal recombinases. This group also includes bacterial conjugation proteins and...; Region: RecA-like_NTPases; cl17233 755731002578 Walker A motif; other site 755731002579 ATP binding site [chemical binding]; other site 755731002580 Walker B motif; other site 755731002581 Type II secretory pathway, component PulF [Cell motility and secretion / Intracellular trafficking and secretion]; Region: PulF; COG1459 755731002582 Type II secretion system (T2SS), protein F; Region: T2SF; pfam00482 755731002583 Type II secretion system (T2SS), protein F; Region: T2SF; pfam00482 755731002584 Type II secretory pathway, prepilin signal peptidase PulO and related peptidases [Cell motility and secretion / Posttranslational modification, protein turnover, chaperones / Intracellular trafficking and secretion]; Region: PulO; COG1989 755731002585 Bacterial Peptidase A24 N-terminal domain; Region: DiS_P_DiS; pfam06750 755731002586 Type IV leader peptidase family; Region: Peptidase_A24; pfam01478 755731002587 Tfp pilus assembly protein, ATPase PilM [Cell motility and secretion / Intracellular trafficking and secretion]; Region: PilM; COG4972 755731002588 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cl17037 755731002589 Fimbrial assembly protein (PilN); Region: PilN; pfam05137 755731002590 PilX N-terminal; Region: PilX_N; pfam14341 755731002591 Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all...; Region: FN3; cd00063 755731002592 Interdomain contacts; other site 755731002593 Cytokine receptor motif; other site 755731002594 domain in bacterial beta-glucosidases other glycosidases, glycosyltransferases, proteases, amidases, yeast adhesins, and bacterial toxins; Region: PA14; smart00758 755731002595 Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all...; Region: FN3; cd00063 755731002596 Interdomain contacts; other site 755731002597 Cytokine receptor motif; other site 755731002598 Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all...; Region: FN3; cd00063 755731002599 Interdomain contacts; other site 755731002600 Cytokine receptor motif; other site 755731002601 Putative glycosyl hydrolase domain; Region: DUF4015; pfam13200 755731002602 ribonucleotide-diphosphate reductase subunit alpha; Validated; Region: PRK08665 755731002603 Ribonucleotide reductase, all-alpha domain; Region: Ribonuc_red_lgN; pfam00317 755731002604 Class II ribonucleotide reductase, dimeric form; Region: RNR_II_dimer; cd02888 755731002605 active site 755731002606 dimer interface [polypeptide binding]; other site 755731002607 effector binding site; other site 755731002608 TSCPD domain; Region: TSCPD; pfam12637 755731002609 flagellar operon protein TIGR03826; Region: YvyF 755731002610 Helix-Turn-Helix DNA binding domain of transcription regulators from the MerR superfamily; Region: HTH_MerR-SF; cl02600 755731002611 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 755731002612 binding surface 755731002613 TPR repeat; Region: TPR_11; pfam13414 755731002614 TPR motif; other site 755731002615 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 755731002616 TPR motif; other site 755731002617 binding surface 755731002618 CARDB; Region: CARDB; pfam07705 755731002619 CARDB; Region: CARDB; pfam07705 755731002620 CARDB; Region: CARDB; pfam07705 755731002621 CARDB; Region: CARDB; pfam07705 755731002622 SGNH_hydrolase subfamily, similar to Ruminococcus flavefaciens XynB. Most likely a secreted hydrolase with xylanase activity. SGNH hydrolases are a diverse family of lipases and esterases. The tertiary fold of the enzyme is substantially different from...; Region: XynB_like; cd01833 755731002623 active site 755731002624 catalytic triad [active] 755731002625 oxyanion hole [active] 755731002626 VanZ like family; Region: VanZ; pfam04892 755731002627 Uncharacterized protein containing a NRPS condensation (elongation) domain [General function prediction only]; Region: COG4908 755731002628 4-hydroxybenzoyl-CoA thioesterase (4HBT). Catalyzes the final step in the 4-chlorobenzoate degradation pathway in which 4-chlorobenzoate is converted to 4-hydroxybenzoate in certain soil-dwelling bacteria. 4HBT forms a homotetramer with four active sites; Region: 4HBT; cd00586 755731002629 active site 755731002630 Phosphotransferase enzyme family; Region: APH; pfam01636 755731002631 Aminoglycoside 3'-phosphotransferase (APH) and Choline Kinase (ChoK) family. The APH/ChoK family is part of a larger superfamily that includes the catalytic domains of other kinases, such as the typical serine/threonine/tyrosine protein kinases (PKs)...; Region: APH_ChoK_like; cd05120 755731002632 active site 755731002633 substrate binding site [chemical binding]; other site 755731002634 ATP binding site [chemical binding]; other site 755731002635 Uncharacterized protein containing a NRPS condensation (elongation) domain [General function prediction only]; Region: COG4908 755731002636 3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05653 755731002637 classical (c) SDRs; Region: SDR_c; cd05233 755731002638 NAD(P) binding site [chemical binding]; other site 755731002639 active site 755731002640 Ketoacyl-acyl carrier protein synthase III (KASIII) initiates the elongation in type II fatty acid synthase systems. It is found in bacteria and plants. Elongation of fatty acids in the type II systems occurs by Claisen condensation of malonyl-acyl...; Region: KAS_III; cd00830 755731002641 3-oxoacyl-[acyl-carrier-protein]; Region: FabH; COG0332 755731002642 dimer interface [polypeptide binding]; other site 755731002643 active site 755731002644 CoA binding pocket [chemical binding]; other site 755731002645 Uncharacterized protein containing a NRPS condensation (elongation) domain [General function prediction only]; Region: COG4908 755731002646 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 755731002647 phenylacetate-CoA ligase; Region: PA_CoA_ligase; TIGR02155 755731002648 acyl-activating enzyme (AAE) consensus motif; other site 755731002649 AMP binding site [chemical binding]; other site 755731002650 active site 755731002651 CoA binding site [chemical binding]; other site 755731002652 Cysteine synthase [Amino acid transport and metabolism]; Region: CysK; COG0031 755731002653 CBS_like: This subgroup includes Cystathionine beta-synthase (CBS) and Cysteine synthase. CBS is a unique heme-containing enzyme that catalyzes a pyridoxal 5'-phosphate (PLP)-dependent condensation of serine and homocysteine to give cystathionine; Region: CBS_like; cd01561 755731002654 dimer interface [polypeptide binding]; other site 755731002655 pyridoxal 5'-phosphate binding site [chemical binding]; other site 755731002656 catalytic residue [active] 755731002657 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 755731002658 active site 755731002659 Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzymes, YBL036c-like proteins; Region: PLPDE_III_YBL036c_like; cd00635 755731002660 pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site 755731002661 catalytic residue [active] 755731002662 Permeases of the drug/metabolite transporter (DMT) superfamily [Carbohydrate transport and metabolism / Amino acid transport and metabolism / General function prediction only]; Region: RhaT; COG0697 755731002663 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 755731002664 hypothetical protein; Provisional; Region: PRK07206 755731002665 ATP-grasp domain; Region: ATP-grasp_4; pfam13535 755731002666 oxalate/formate antiporter family transporter; Region: 2A0111; TIGR00890 755731002667 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 755731002668 putative substrate translocation pore; other site 755731002669 S-layer homology domain; Region: SLH; pfam00395 755731002670 S-layer homology domain; Region: SLH; pfam00395 755731002671 Right handed beta helix region; Region: Beta_helix; pfam13229 755731002672 A predicted NlpC/p60-like peptidase; Region: BtrH; pfam14399 755731002673 A predicted NlpC/p60-like peptidase; Region: BtrH; pfam14399 755731002674 Condensation domain; Region: Condensation; pfam00668 755731002675 Non-ribosomal peptide synthetase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: EntF; COG1020 755731002676 The adenylation domain of nonribosomal peptide synthetases (NRPS); Region: A_NRPS; cd05930 755731002677 acyl-activating enzyme (AAE) consensus motif; other site 755731002678 AMP binding site [chemical binding]; other site 755731002679 Phosphopantetheine attachment site; Region: PP-binding; pfam00550 755731002680 Condensation domain; Region: Condensation; pfam00668 755731002681 non-ribosomal peptide synthase domain TIGR01720; Region: NRPS-para261 755731002682 Beta-lactamase class C and other penicillin binding proteins [Defense mechanisms]; Region: AmpC; COG1680 755731002683 Beta-lactamase; Region: Beta-lactamase; pfam00144 755731002684 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 755731002685 ABC-type siderophore export system, fused ATPase and permease components [Secondary metabolites biosynthesis, transport, and catabolism / Inorganic ion transport and metabolism]; Region: PvdE; COG4615 755731002686 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 755731002687 Walker A/P-loop; other site 755731002688 ATP binding site [chemical binding]; other site 755731002689 Q-loop/lid; other site 755731002690 ABC transporter signature motif; other site 755731002691 Walker B; other site 755731002692 D-loop; other site 755731002693 H-loop/switch region; other site 755731002694 FkbH-like domain; Region: FkbH; TIGR01686 755731002695 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 755731002696 active site 755731002697 motif I; other site 755731002698 motif II; other site 755731002699 Phosphopantetheine attachment site; Region: PP-binding; cl09936 755731002700 3-hydroxyacyl-CoA dehydrogenase, NAD binding domain; Region: 3HCDH_N; pfam02737 755731002701 3-hydroxybutyryl-CoA dehydrogenase; Validated; Region: PRK05808 755731002702 3-hydroxyacyl-CoA dehydrogenase, C-terminal domain; Region: 3HCDH; pfam00725 755731002703 Phosphopantetheine attachment site; Region: PP-binding; cl09936 755731002704 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 755731002705 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 755731002706 active site 755731002707 The adenylation domain of nonribosomal peptide synthetases (NRPS); Region: A_NRPS; cd05930 755731002708 amino acid adenylation domain; Region: AA-adenyl-dom; TIGR01733 755731002709 acyl-activating enzyme (AAE) consensus motif; other site 755731002710 AMP binding site [chemical binding]; other site 755731002711 (acyl-carrier-protein) S-malonyltransferase [Lipid metabolism]; Region: FabD; COG0331 755731002712 malonyl CoA-acyl carrier protein transacylase; Region: fabD; TIGR00128 755731002713 GNAT acetyltransferase; Region: GNAT_acetyltran; pfam12746 755731002714 Acetyltransferase (GNAT) domain; Region: Acetyltransf_3; pfam13302 755731002715 Condensation domain; Region: Condensation; pfam00668 755731002716 Non-ribosomal peptide synthetase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: EntF; COG1020 755731002717 The adenylation domain of nonribosomal peptide synthetases (NRPS); Region: A_NRPS; cd05930 755731002718 acyl-activating enzyme (AAE) consensus motif; other site 755731002719 AMP binding site [chemical binding]; other site 755731002720 Phosphopantetheine attachment site; Region: PP-binding; pfam00550 755731002721 polyketide synthases (PKSs) polymerize simple fatty acids into a large variety of different products, called polyketides, by successive decarboxylating Claisen condensations. PKSs can be divided into 2 groups, modular type I PKSs consisting of one or...; Region: PKS; cd00833 755731002722 Beta-ketoacyl synthase; Region: PKS_KS; smart00825 755731002723 active site 755731002724 Acyl transferase domain; Region: Acyl_transf_1; cl08282 755731002725 ketoreductase (KR), subgroup 2, complex (x) SDRs; Region: KR_2_SDR_x; cd08953 755731002726 This enzymatic domain is part of bacterial polyketide synthases; Region: PKS_KR; smart00822 755731002727 putative NADP binding site [chemical binding]; other site 755731002728 active site 755731002729 Phosphopantetheine attachment site; Region: PP-binding; pfam00550 755731002730 polyketide synthases (PKSs) polymerize simple fatty acids into a large variety of different products, called polyketides, by successive decarboxylating Claisen condensations. PKSs can be divided into 2 groups, modular type I PKSs consisting of one or...; Region: PKS; cd00833 755731002731 Beta-ketoacyl synthase; Region: PKS_KS; smart00825 755731002732 active site 755731002733 malonyl CoA-acyl carrier protein transacylase; Region: fabD; TIGR00128 755731002734 Acyl transferase domain in polyketide synthase (PKS) enzymes; Region: PKS_AT; smart00827 755731002735 ketoreductase (KR), subgroup 2, complex (x) SDRs; Region: KR_2_SDR_x; cd08953 755731002736 This enzymatic domain is part of bacterial polyketide synthases; Region: PKS_KR; smart00822 755731002737 putative NADP binding site [chemical binding]; other site 755731002738 active site 755731002739 Phosphopantetheine attachment site; Region: PP-binding; pfam00550 755731002740 Condensation domain; Region: Condensation; pfam00668 755731002741 Non-ribosomal peptide synthetase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: EntF; COG1020 755731002742 HxxPF-repeated domain; Region: HxxPF_rpt; pfam13745 755731002743 The adenylation domain of nonribosomal peptide synthetases (NRPS); Region: A_NRPS; cd05930 755731002744 acyl-activating enzyme (AAE) consensus motif; other site 755731002745 AMP binding site [chemical binding]; other site 755731002746 Phosphopantetheine attachment site; Region: PP-binding; pfam00550 755731002747 polyketide synthases (PKSs) polymerize simple fatty acids into a large variety of different products, called polyketides, by successive decarboxylating Claisen condensations. PKSs can be divided into 2 groups, modular type I PKSs consisting of one or...; Region: PKS; cd00833 755731002748 Beta-ketoacyl synthase; Region: PKS_KS; smart00825 755731002749 active site 755731002750 malonyl CoA-acyl carrier protein transacylase; Region: fabD; TIGR00128 755731002751 Acyl transferase domain in polyketide synthase (PKS) enzymes; Region: PKS_AT; smart00827 755731002752 ketoreductase (KR), subgroup 2, complex (x) SDRs; Region: KR_2_SDR_x; cd08953 755731002753 This enzymatic domain is part of bacterial polyketide synthases; Region: PKS_KR; smart00822 755731002754 putative NADP binding site [chemical binding]; other site 755731002755 active site 755731002756 Phosphopantetheine attachment site; Region: PP-binding; pfam00550 755731002757 Condensation domain; Region: Condensation; pfam00668 755731002758 Non-ribosomal peptide synthetase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: EntF; COG1020 755731002759 HxxPF-repeated domain; Region: HxxPF_rpt; pfam13745 755731002760 The adenylation domain of nonribosomal peptide synthetases (NRPS); Region: A_NRPS; cd05930 755731002761 acyl-activating enzyme (AAE) consensus motif; other site 755731002762 AMP binding site [chemical binding]; other site 755731002763 Phosphopantetheine attachment site; Region: PP-binding; pfam00550 755731002764 Condensation domain; Region: Condensation; pfam00668 755731002765 non-ribosomal peptide synthase domain TIGR01720; Region: NRPS-para261 755731002766 Condensation domain; Region: Condensation; pfam00668 755731002767 Non-ribosomal peptide synthetase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: EntF; COG1020 755731002768 The adenylation domain of nonribosomal peptide synthetases (NRPS); Region: A_NRPS; cd05930 755731002769 acyl-activating enzyme (AAE) consensus motif; other site 755731002770 AMP binding site [chemical binding]; other site 755731002771 Phosphopantetheine attachment site; Region: PP-binding; pfam00550 755731002772 Condensation domain; Region: Condensation; pfam00668 755731002773 Non-ribosomal peptide synthetase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: EntF; COG1020 755731002774 HxxPF-repeated domain; Region: HxxPF_rpt; pfam13745 755731002775 Peptidase family U32; Region: Peptidase_U32; cl03113 755731002776 The adenylation domain of nonribosomal peptide synthetases (NRPS); Region: A_NRPS; cd05930 755731002777 amino acid adenylation domain; Region: AA-adenyl-dom; TIGR01733 755731002778 acyl-activating enzyme (AAE) consensus motif; other site 755731002779 AMP binding site [chemical binding]; other site 755731002780 Phosphopantetheine attachment site; Region: PP-binding; pfam00550 755731002781 Condensation domain; Region: Condensation; pfam00668 755731002782 Non-ribosomal peptide synthetase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: EntF; COG1020 755731002783 HxxPF-repeated domain; Region: HxxPF_rpt; pfam13745 755731002784 The adenylation domain of nonribosomal peptide synthetases (NRPS); Region: A_NRPS; cd05930 755731002785 acyl-activating enzyme (AAE) consensus motif; other site 755731002786 AMP binding site [chemical binding]; other site 755731002787 Phosphopantetheine attachment site; Region: PP-binding; pfam00550 755731002788 (acyl-carrier-protein) S-malonyltransferase [Lipid metabolism]; Region: FabD; COG0331 755731002789 malonyl CoA-acyl carrier protein transacylase; Region: fabD; TIGR00128 755731002790 polyketide synthases (PKSs) polymerize simple fatty acids into a large variety of different products, called polyketides, by successive decarboxylating Claisen condensations. PKSs can be divided into 2 groups, modular type I PKSs consisting of one or...; Region: PKS; cd00833 755731002791 Beta-ketoacyl synthase; Region: PKS_KS; smart00825 755731002792 active site 755731002793 Phosphopantetheine attachment site; Region: PP-binding; pfam00550 755731002794 Condensation domain; Region: Condensation; pfam00668 755731002795 Non-ribosomal peptide synthetase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: EntF; COG1020 755731002796 HxxPF-repeated domain; Region: HxxPF_rpt; pfam13745 755731002797 The adenylation domain of nonribosomal peptide synthetases (NRPS); Region: A_NRPS; cd05930 755731002798 acyl-activating enzyme (AAE) consensus motif; other site 755731002799 AMP binding site [chemical binding]; other site 755731002800 Phosphopantetheine attachment site; Region: PP-binding; pfam00550 755731002801 polyketide synthases (PKSs) polymerize simple fatty acids into a large variety of different products, called polyketides, by successive decarboxylating Claisen condensations. PKSs can be divided into 2 groups, modular type I PKSs consisting of one or...; Region: PKS; cd00833 755731002802 Beta-ketoacyl synthase; Region: PKS_KS; smart00825 755731002803 active site 755731002804 Dehydratase domain in polyketide synthase (PKS) enzymes; Region: PKS_DH; smart00826 755731002805 ketoreductase (KR), subgroup 2, complex (x) SDRs; Region: KR_2_SDR_x; cd08953 755731002806 This enzymatic domain is part of bacterial polyketide synthases; Region: PKS_KR; smart00822 755731002807 putative NADP binding site [chemical binding]; other site 755731002808 active site 755731002809 Phosphopantetheine attachment site; Region: PP-binding; pfam00550 755731002810 Condensation domain; Region: Condensation; pfam00668 755731002811 Non-ribosomal peptide synthetase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: EntF; COG1020 755731002812 HxxPF-repeated domain; Region: HxxPF_rpt; pfam13745 755731002813 Predicted enzyme involved in methoxymalonyl-ACP biosynthesis [Secondary metabolites biosynthesis, transport, and catabolism]; Region: FkbH; COG3882 755731002814 Acid Phosphatase; Region: Acid_PPase; cl17256 755731002815 Phosphopantetheine attachment site; Region: PP-binding; pfam00550 755731002816 Condensation domain; Region: Condensation; pfam00668 755731002817 Non-ribosomal peptide synthetase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: EntF; COG1020 755731002818 HxxPF-repeated domain; Region: HxxPF_rpt; pfam13745 755731002819 Predicted enzyme involved in methoxymalonyl-ACP biosynthesis [Secondary metabolites biosynthesis, transport, and catabolism]; Region: FkbH; COG3882 755731002820 HAD-superfamily phosphatase, subfamily IIIC; Region: HAD-SF-IIIC; TIGR01681 755731002821 Phosphopantetheine attachment site; Region: PP-binding; pfam00550 755731002822 Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673 755731002823 Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408 755731002824 Dehydroquinase (DHQase), type II. Dehydroquinase (or 3-dehydroquinate dehydratase) catalyzes the reversible dehydration of 3-dehydroquinate to form 3-dehydroshikimate. This reaction is part of two metabolic pathways: the biosynthetic shikimate pathway...; Region: DHQase_II; cd00466 755731002825 Dehydroquinase class II; Region: DHquinase_II; pfam01220 755731002826 trimer interface [polypeptide binding]; other site 755731002827 active site 755731002828 dimer interface [polypeptide binding]; other site 755731002829 GTPase RsgA; Reviewed; Region: PRK01889 755731002830 S1_like: Ribosomal protein S1-like RNA-binding domain. Found in a wide variety of RNA-associated proteins. Originally identified in S1 ribosomal protein. This superfamily also contains the Cold Shock Domain (CSD), which is a homolog of the S1 domain; Region: S1_like; cl09927 755731002831 RNA binding site [nucleotide binding]; other site 755731002832 Ribosomal interacting GTPase YjeQ/EngC, a circularly permuted subfamily of the Ras GTPases; Region: YjeQ_EngC; cd01854 755731002833 GTPase/Zn-binding domain interface [polypeptide binding]; other site 755731002834 GTP/Mg2+ binding site [chemical binding]; other site 755731002835 G4 box; other site 755731002836 G5 box; other site 755731002837 G1 box; other site 755731002838 Switch I region; other site 755731002839 G2 box; other site 755731002840 G3 box; other site 755731002841 Switch II region; other site 755731002842 3-amino-5-hydroxybenoic acid synthesis related protein; Region: AHBA_synth_RP; TIGR01454 755731002843 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 755731002844 motif II; other site 755731002845 Acyl carrier protein [Lipid metabolism / Secondary metabolites biosynthesis, transport, and catabolism]; Region: AcpP; COG0236 755731002846 Alpha-L-arabinofuranosidase [Carbohydrate transport and metabolism]; Region: AbfA; COG3534 755731002847 Alpha-L-arabinofuranosidase C-terminus; Region: Alpha-L-AF_C; pfam06964 755731002848 Predicted transcriptional regulator [Transcription]; Region: COG4189 755731002849 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 755731002850 putative DNA binding site [nucleotide binding]; other site 755731002851 dimerization interface [polypeptide binding]; other site 755731002852 putative Zn2+ binding site [ion binding]; other site 755731002853 Periplasmic binding domain of ABC-type YtfQ-like transport systems; Region: PBP1_YtfQ_like; cd06309 755731002854 Periplasmic binding protein domain; Region: Peripla_BP_4; pfam13407 755731002855 putative ligand binding site [chemical binding]; other site 755731002856 ABC-type sugar transport system, ATPase component [Carbohydrate transport and metabolism]; Region: MglA; COG1129 755731002857 First domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_I; cd03216 755731002858 Walker A/P-loop; other site 755731002859 ATP binding site [chemical binding]; other site 755731002860 Q-loop/lid; other site 755731002861 ABC transporter signature motif; other site 755731002862 Walker B; other site 755731002863 D-loop; other site 755731002864 H-loop/switch region; other site 755731002865 Second domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_II; cd03215 755731002866 Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653 755731002867 Transmembrane subunit (TM) of Escherichia coli AraH and related proteins. E. coli AraH is the TM of a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of the monosaccharide arabinose. This group...; Region: TM_PBP1_transp_AraH_like; cd06579 755731002868 TM-ABC transporter signature motif; other site 755731002869 Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653 755731002870 Transmembrane subunit (TM) of Escherichia coli AraH and related proteins. E. coli AraH is the TM of a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of the monosaccharide arabinose. This group...; Region: TM_PBP1_transp_AraH_like; cd06579 755731002871 TM-ABC transporter signature motif; other site 755731002872 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 755731002873 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 755731002874 dimerization interface [polypeptide binding]; other site 755731002875 Histidine kinase; Region: His_kinase; pfam06580 755731002876 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 755731002877 ATP binding site [chemical binding]; other site 755731002878 Mg2+ binding site [ion binding]; other site 755731002879 G-X-G motif; other site 755731002880 Response regulator containing CheY-like receiver domain and AraC-type DNA-binding domain [Signal transduction mechanisms]; Region: COG4753 755731002881 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 755731002882 active site 755731002883 phosphorylation site [posttranslational modification] 755731002884 intermolecular recognition site; other site 755731002885 dimerization interface [polypeptide binding]; other site 755731002886 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 755731002887 Glycosyl hydrolase family 10; Region: Glyco_10; smart00633 755731002888 Carbohydrate Binding Module 6 (CBM6); many are appended to glycoside hydrolase (GH) family 11 and GH43 xylanase domains; Region: CBM6_xylanase-like; cd04084 755731002889 metal binding site [ion binding]; metal-binding site 755731002890 ligand binding site [chemical binding]; other site 755731002891 Glycosyl hydrolase family 43, includes arabinoxylan arabinofuranohydrolase, beta-xylosidase, endo-1,4-beta-xylanase, alpha-L-arabinofuranosidase; Region: GH43_AXH_like; cd08990 755731002892 substrate binding site [chemical binding]; other site 755731002893 active site 755731002894 Carbohydrate Binding Module 6 (CBM6); many are appended to glycoside hydrolase (GH) family 11 and GH43 xylanase domains; Region: CBM6_xylanase-like; cd04084 755731002895 metal binding site [ion binding]; metal-binding site 755731002896 ligand binding site [chemical binding]; other site 755731002897 Dockerin type I repeat; Region: Dockerin_1; pfam00404 755731002898 Dockerin type I repeat; Region: Dockerin_1; pfam00404 755731002899 Predicted hydrolase of the alpha/beta superfamily [General function prediction only]; Region: COG2819 755731002900 Alpha/beta hydrolase family; Region: Abhydrolase_5; pfam12695 755731002901 Carbohydrate Binding Module 6 (CBM6); many are appended to glycoside hydrolase (GH) family 11 and GH43 xylanase domains; Region: CBM6_xylanase-like; cd04084 755731002902 metal binding site [ion binding]; metal-binding site 755731002903 ligand binding site [chemical binding]; other site 755731002904 Dockerin type I repeat; Region: Dockerin_1; pfam00404 755731002905 Beta-xylosidase [Carbohydrate transport and metabolism]; Region: XynB; COG3507 755731002906 Glycosyl hydrolase family 43, beta-D-xylosidase; Region: GH43_XYL_2; cd09001 755731002907 active site 755731002908 Carbohydrate Binding Module 6 (CBM6); many are appended to glycoside hydrolase (GH) family 11 and GH43 xylanase domains; Region: CBM6_xylanase-like; cd04084 755731002909 metal binding site [ion binding]; metal-binding site 755731002910 ligand binding site [chemical binding]; other site 755731002911 Dockerin type I repeat; Region: Dockerin_1; pfam00404 755731002912 Dockerin type I repeat; Region: Dockerin_1; pfam00404 755731002913 Glycosyl hydrolase families: GH43, GH62, GH32, GH68; Region: GH43_62_32_68; cl14647 755731002914 active site 755731002915 Carbohydrate Binding Module 6 (CBM6); many are appended to glycoside hydrolase (GH) family 11 and GH43 xylanase domains; Region: CBM6_xylanase-like; cd04084 755731002916 metal binding site [ion binding]; metal-binding site 755731002917 ligand binding site [chemical binding]; other site 755731002918 Dockerin type I repeat; Region: Dockerin_1; pfam00404 755731002919 Dockerin type I repeat; Region: Dockerin_1; pfam00404 755731002920 Glycosyl hydrolase family 43, includes arabinoxylan arabinofuranohydrolase, beta-xylosidase, endo-1,4-beta-xylanase, alpha-L-arabinofuranosidase; Region: GH43_AXH_like; cd08990 755731002921 substrate binding site [chemical binding]; other site 755731002922 active site 755731002923 Carbohydrate Binding Module 6 (CBM6); many are appended to glycoside hydrolase (GH) family 11 and GH43 xylanase domains; Region: CBM6_xylanase-like; cd04084 755731002924 metal binding site [ion binding]; metal-binding site 755731002925 ligand binding site [chemical binding]; other site 755731002926 Dockerin type I repeat; Region: Dockerin_1; pfam00404 755731002927 Putative glycosyl hydrolase of unknown function (DUF1680); Region: DUF1680; pfam07944 755731002928 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3533 755731002929 Carbohydrate binding domain; Region: CBM_4_9; pfam02018 755731002930 Beta/Gamma crystallin; Region: Crystall; cl02528 755731002931 Dockerin type I repeat; Region: Dockerin_1; pfam00404 755731002932 alpha-galactosidase; Region: PLN02808; cl17638 755731002933 Carbohydrate Binding Module 6 (CBM6); many are appended to glycoside hydrolase (GH) family 11 and GH43 xylanase domains; Region: CBM6_xylanase-like; cd04084 755731002934 metal binding site [ion binding]; metal-binding site 755731002935 ligand binding site [chemical binding]; other site 755731002936 Beta-galactosidase/beta-glucuronidase [Carbohydrate transport and metabolism]; Region: LacZ; COG3250 755731002937 Glycosyl hydrolases family 2, sugar binding domain; Region: Glyco_hydro_2_N; pfam02837 755731002938 Glycosyl hydrolases family 2; Region: Glyco_hydro_2; pfam00703 755731002939 Glycosyl hydrolases family 2, TIM barrel domain; Region: Glyco_hydro_2_C; pfam02836 755731002940 Bacterial Ig-like domain (group 1); Region: Big_1; cl17740 755731002941 Carbohydrate Binding Module 6 (CBM6); many are appended to glycoside hydrolase (GH) family 11 and GH43 xylanase domains; Region: CBM6_xylanase-like; cd04084 755731002942 metal binding site [ion binding]; metal-binding site 755731002943 ligand binding site [chemical binding]; other site 755731002944 Dockerin type I repeat; Region: Dockerin_1; pfam00404 755731002945 Glycosyl hydrolase families: GH43, GH62, GH32, GH68; Region: GH43_62_32_68; cl14647 755731002946 active site 755731002947 Carbohydrate Binding Module 6 (CBM6); many are appended to glycoside hydrolase (GH) family 11 and GH43 xylanase domains; Region: CBM6_xylanase-like; cd04084 755731002948 metal binding site [ion binding]; metal-binding site 755731002949 ligand binding site [chemical binding]; other site 755731002950 Dockerin type I repeat; Region: Dockerin_1; pfam00404 755731002951 Dockerin type I repeat; Region: Dockerin_1; pfam00404 755731002952 Domain of unknown function (DUF303); Region: DUF303; pfam03629 755731002953 Coagulation factor 5/8 C-terminal domain, discoidin domain; Region: FA58C; smart00231 755731002954 F5/8 type C domain; Region: F5_F8_type_C; pfam00754 755731002955 sugar binding site [chemical binding]; other site 755731002956 Carbohydrate Binding Module 6 (CBM6); many are appended to glycoside hydrolase (GH) family 11 and GH43 xylanase domains; Region: CBM6_xylanase-like; cd04084 755731002957 metal binding site [ion binding]; metal-binding site 755731002958 ligand binding site [chemical binding]; other site 755731002959 Dockerin type I repeat; Region: Dockerin_1; pfam00404 755731002960 O-Glycosyl hydrolase [Cell envelope biogenesis, outer membrane]; Region: COG5520 755731002961 O-Glycosyl hydrolase family 30; Region: Glyco_hydro_30; pfam02055 755731002962 Carbohydrate Binding Module 6 (CBM6); many are appended to glycoside hydrolase (GH) family 11 and GH43 xylanase domains; Region: CBM6_xylanase-like; cd04084 755731002963 metal binding site [ion binding]; metal-binding site 755731002964 ligand binding site [chemical binding]; other site 755731002965 Dockerin type I repeat; Region: Dockerin_1; pfam00404 755731002966 Predicted hydrolase of the alpha/beta superfamily [General function prediction only]; Region: COG2819 755731002967 Putative esterase; Region: Esterase; pfam00756 755731002968 Carbohydrate Binding Module 6 (CBM6); many are appended to glycoside hydrolase (GH) family 11 and GH43 xylanase domains; Region: CBM6_xylanase-like; cd04084 755731002969 metal binding site [ion binding]; metal-binding site 755731002970 ligand binding site [chemical binding]; other site 755731002971 Dockerin type I repeat; Region: Dockerin_1; pfam00404 755731002972 TRX family; composed of two groups: Group I, which includes proteins that exclusively encode a TRX domain; and Group II, which are composed of fusion proteins of TRX and additional domains. Group I TRX is a small ancient protein that alter the redox...; Region: TRX_family; cd02947 755731002973 catalytic residues [active] 755731002974 Pectic acid lyase; Region: Pec_lyase; pfam09492 755731002975 This group contains class II terpene cyclases, protein prenyltransferases beta subunit, two broadly specific proteinase inhibitors alpha2-macroglobulin (alpha (2)-M) and pregnancy zone protein (PZP) and, the C3 C4 and C5 components of vertebrate...; Region: ISOPREN_C2_like; cl08267 755731002976 Dockerin type I repeat; Region: Dockerin_1; pfam00404 755731002977 Pectinesterase; Region: Pectinesterase; pfam01095 755731002978 putative pectinesterase; Region: PLN02432; cl01911 755731002979 Dockerin type I repeat; Region: Dockerin_1; pfam00404 755731002980 Dockerin type I repeat; Region: Dockerin_1; pfam00404 755731002981 Rhamnogalacturonan lyase of the polysaccharide lyase family 11; Region: RGL11; cd10318 755731002982 metal binding site [ion binding]; metal-binding site 755731002983 active site 755731002984 Dockerin type I repeat; Region: Dockerin_1; pfam00404 755731002985 ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132 755731002986 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 755731002987 Walker A/P-loop; other site 755731002988 ATP binding site [chemical binding]; other site 755731002989 Q-loop/lid; other site 755731002990 ABC transporter signature motif; other site 755731002991 Walker B; other site 755731002992 D-loop; other site 755731002993 H-loop/switch region; other site 755731002994 ABC-type cobalt transport system, ATPase component [Inorganic ion transport and metabolism]; Region: CbiO; COG1122 755731002995 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 755731002996 Walker A/P-loop; other site 755731002997 ATP binding site [chemical binding]; other site 755731002998 Q-loop/lid; other site 755731002999 ABC transporter signature motif; other site 755731003000 Walker B; other site 755731003001 D-loop; other site 755731003002 H-loop/switch region; other site 755731003003 putative transposase OrfB; Reviewed; Region: PHA02517 755731003004 HTH-like domain; Region: HTH_21; pfam13276 755731003005 Integrase core domain; Region: rve; pfam00665 755731003006 Integrase core domain; Region: rve_2; pfam13333 755731003007 endoglucanase; Region: PLN02308 755731003008 Glycosyl hydrolase family 9; Region: Glyco_hydro_9; pfam00759 755731003009 Cellulose binding domain; Region: CBM_3; smart01067 755731003010 Dockerin type I repeat; Region: Dockerin_1; pfam00404 755731003011 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 755731003012 dimerization interface [polypeptide binding]; other site 755731003013 Histidine kinase; Region: His_kinase; pfam06580 755731003014 Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase; Region: HATPase_c; pfam02518 755731003015 ATP binding site [chemical binding]; other site 755731003016 Mg2+ binding site [ion binding]; other site 755731003017 G-X-G motif; other site 755731003018 Response regulator receiver domain; Region: Response_reg; pfam00072 755731003019 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 755731003020 active site 755731003021 phosphorylation site [posttranslational modification] 755731003022 intermolecular recognition site; other site 755731003023 dimerization interface [polypeptide binding]; other site 755731003024 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 755731003025 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 755731003026 ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653 755731003027 ABC-type polysaccharide transport system, permease component [Carbohydrate transport and metabolism]; Region: LplB; COG4209 755731003028 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 755731003029 dimer interface [polypeptide binding]; other site 755731003030 conserved gate region; other site 755731003031 putative PBP binding loops; other site 755731003032 ABC-ATPase subunit interface; other site 755731003033 ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395 755731003034 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 755731003035 dimer interface [polypeptide binding]; other site 755731003036 conserved gate region; other site 755731003037 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cl00427 755731003038 ABC-ATPase subunit interface; other site 755731003039 Alpha-L-arabinofuranosidase [Carbohydrate transport and metabolism]; Region: AbfA; COG3534 755731003040 Alpha-L-arabinofuranosidase C-terminus; Region: Alpha-L-AF_C; pfam06964 755731003041 Beta-xylosidase [Carbohydrate transport and metabolism]; Region: XynB; COG3507 755731003042 Glycosyl hydrolase family 43, beta-D-xylosidase; Region: GH43_XYL_2; cd09001 755731003043 active site 755731003044 Glycosyl hydrolases family 39; Region: Glyco_hydro_39; pfam01229 755731003045 Putative esterase; Region: Esterase; pfam00756 755731003046 Predicted hydrolase of the alpha/beta superfamily [General function prediction only]; Region: COG2819 755731003047 Glycosyl hydrolase family 76; Region: Glyco_hydro_76; cl01996 755731003048 Domain of unknown function (DUF303); Region: DUF303; pfam03629 755731003049 Glycosyl hydrolases family 2, sugar binding domain; Region: Glyco_hydro_2_N; pfam02837 755731003050 Domain of unknown function (DUF303); Region: DUF303; pfam03629 755731003051 cobalt transport protein CbiM; Validated; Region: PRK08319 755731003052 Cobalt uptake substrate-specific transmembrane region; Region: CbiM; pfam01891 755731003053 cobalt transport protein CbiN; Provisional; Region: PRK02898 755731003054 cobalt ABC transporter, permease protein CbiQ; Region: CbiQ_TIGR; TIGR02454 755731003055 cobalt transporter ATP-binding subunit; Provisional; Region: cbiO; PRK13636 755731003056 First domain of the ATP-binding cassette component of cobalt transport system; Region: ABC_cobalt_CbiO_domain1; cd03225 755731003057 Walker A/P-loop; other site 755731003058 ATP binding site [chemical binding]; other site 755731003059 Q-loop/lid; other site 755731003060 ABC transporter signature motif; other site 755731003061 Walker B; other site 755731003062 D-loop; other site 755731003063 H-loop/switch region; other site 755731003064 cobalt-precorrin-6A synthase; Reviewed; Region: cbiD; PRK00075 755731003065 Precorrin-2 C20-methyltransferase, also named CobI or CbiL; Region: Precorrin_2_C20_MT; cd11645 755731003066 active site 755731003067 SAM binding site [chemical binding]; other site 755731003068 homodimer interface [polypeptide binding]; other site 755731003069 Precorrin-4 C11-methyltransferase (CbiF/CobM); Region: Precorrin-4_C11-MT; cd11641 755731003070 active site 755731003071 SAM binding site [chemical binding]; other site 755731003072 homodimer interface [polypeptide binding]; other site 755731003073 cobalamin biosynthesis protein CbiG; Validated; Region: PRK05788 755731003074 Cobalamin synthesis G N-terminal; Region: CbiG_N; pfam11760 755731003075 Cobalamin biosynthesis central region; Region: CbiG_mid; pfam11761 755731003076 Cobalamin synthesis G C-terminus; Region: CbiG_C; pfam01890 755731003077 glutamyl-tRNA reductase; Reviewed; Region: hemA; PRK00045 755731003078 NADP-binding domain of glutamyl-tRNA reductase; Region: NAD_bind_Glutamyl_tRNA_reduct; cd05213 755731003079 tRNA; other site 755731003080 putative tRNA binding site [nucleotide binding]; other site 755731003081 putative NADP binding site [chemical binding]; other site 755731003082 Precorrin-3B C(17)-methyltransferase (CobJ/CbiH); Region: Precorrin_3B_C17_MT; cd11646 755731003083 active site 755731003084 SAM binding site [chemical binding]; other site 755731003085 homodimer interface [polypeptide binding]; other site 755731003086 Precorrin-6x reductase CbiJ/CobK; Region: CbiJ; pfam02571 755731003087 Siroheme synthase (precorrin-2 oxidase/ferrochelatase domain) [Coenzyme metabolism]; Region: CysG; COG1648 755731003088 Putative NAD(P)-binding; Region: NAD_binding_7; pfam13241 755731003089 porphobilinogen deaminase; Reviewed; Region: hemC; PRK00072 755731003090 Hydroxymethylbilane synthase (HMBS), also known as porphobilinogen deaminase (PBGD), is an intermediate enzyme in the biosynthetic pathway of tetrapyrrolic ring systems, such as heme, chlorophylls, and vitamin B12. HMBS catalyzes the conversion of...; Region: HMBS; cd00494 755731003091 domain interfaces; other site 755731003092 active site 755731003093 Uroporphyrin-III C-methyltransferase (S-Adenosyl-L-methionine:uroporphyrinogen III methyltransferase, SUMT); Region: SUMT; cd11642 755731003094 active site 755731003095 SAM binding site [chemical binding]; other site 755731003096 homodimer interface [polypeptide binding]; other site 755731003097 Uroporphyrinogen-III synthase [Coenzyme metabolism]; Region: HemD; COG1587 755731003098 Uroporphyrinogen-III synthase (HemD) catalyzes the asymmetrical cyclization of tetrapyrrole (linear) to uroporphyrinogen-III, the fourth step in the biosynthesis of heme. This ubiquitous enzyme is present in eukaryotes, bacteria and archaea. Mutations in...; Region: HemD; cd06578 755731003099 active site 755731003100 Porphobilinogen synthase (PBGS), which is also called delta-aminolevulinic acid dehydratase (ALAD), catalyzes the condensation of two 5-aminolevulinic acid (ALA) molecules to form the pyrrole porphobilinogen (PBG), which is the second step in the...; Region: ALAD_PBGS; cd00384 755731003101 dimer interface [polypeptide binding]; other site 755731003102 active site 755731003103 Schiff base residues; other site 755731003104 glutamate-1-semialdehyde aminotransferase; Provisional; Region: PRK00062 755731003105 Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610 755731003106 inhibitor-cofactor binding pocket; inhibition site 755731003107 pyridoxal 5'-phosphate binding site [chemical binding]; other site 755731003108 catalytic residue [active] 755731003109 Sirohydrochlorin cobalt chelatase (CbiX) and sirohydrochlorin iron chelatase (SirB), N-terminal domain. SirB catalyzes the ferro-chelation of sirohydrochlorin to siroheme, the prosthetic group of sulfite and nitrite reductases. CbiX is a cobaltochelatase; Region: CbiX_SirB_N; cd03416 755731003110 putative active site [active] 755731003111 Precorrin-6Y methyltransferase, the cobalamin biosynthesis enzyme CbiE; Region: Precorrin-6Y-methylase; cd11644 755731003112 active site 755731003113 putative homodimer interface [polypeptide binding]; other site 755731003114 SAM binding site [chemical binding]; other site 755731003115 Precorrin-6B methylase 2 [Coenzyme metabolism]; Region: CobL; COG2242 755731003116 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 755731003117 S-adenosylmethionine binding site [chemical binding]; other site 755731003118 cobyrinic acid a,c-diamide synthase; Validated; Region: PRK01077 755731003119 Dethiobiotin synthetase [Coenzyme metabolism]; Region: BioD; COG0132 755731003120 Type 1 glutamine amidotransferase (GATase1) domain found in Cobyrinic Acid a,c-Diamide Synthase; Region: GATase1_CobB; cd03130 755731003121 catalytic triad [active] 755731003122 cobyric acid synthase; Provisional; Region: PRK00784 755731003123 The Fer4_NifH superfamily contains a variety of proteins which share a common ATP-binding domain. Functionally, proteins in this superfamily use the energy from hydrolysis of NTP to transfer electron or ion; Region: Fer4_NifH; cl17203 755731003124 The Fer4_NifH superfamily contains a variety of proteins which share a common ATP-binding domain. Functionally, proteins in this superfamily use the energy from hydrolysis of NTP to transfer electron or ion; Region: Fer4_NifH; cl17203 755731003125 Type 1 glutamine amidotransferase (GATase1) domain found in Cobyric Acid Synthase (CobQ); Region: GATase1_CobQ; cd01750 755731003126 catalytic triad [active] 755731003127 cobalt-precorrin-8X methylmutase; Validated; Region: cbiC; cl00913 755731003128 Precorrin-8X methylmutase; Region: CbiC; pfam02570 755731003129 CobD/Cbib protein; Region: CobD_Cbib; pfam03186 755731003130 threonine-phosphate decarboxylase; Provisional; Region: PRK06358 755731003131 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 755731003132 pyridoxal 5'-phosphate binding site [chemical binding]; other site 755731003133 homodimer interface [polypeptide binding]; other site 755731003134 catalytic residue [active] 755731003135 5-methylribose kinase; Reviewed; Region: PRK12396 755731003136 Phosphotransferase enzyme family; Region: APH; pfam01636 755731003137 methylthioribose-1-phosphate isomerase; Reviewed; Region: mtnA; PRK05720 755731003138 S-methyl-5-thioribose-1-phosphate isomerase; Region: salvage_mtnA; TIGR00512 755731003139 Class II Aldolase and Adducin N-terminal domain; Region: Aldolase_II; pfam00596 755731003140 intersubunit interface [polypeptide binding]; other site 755731003141 active site 755731003142 Zn2+ binding site [ion binding]; other site 755731003143 Streptomycin adenylyltransferase; Region: Adenyl_transf; pfam04439 755731003144 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4627 755731003145 Methyltransferase domain; Region: Methyltransf_23; pfam13489 755731003146 Protein of unknown function (DUF1232); Region: DUF1232; cl01318 755731003147 Acetyltransferase (GNAT) domain; Region: Acetyltransf_3; pfam13302 755731003148 Acetyltransferase (GNAT) family; Region: Acetyltransf_1; pfam00583 755731003149 Glycosyl hydrolases family 8; Region: Glyco_hydro_8; cl01351 755731003150 Dockerin type I repeat; Region: Dockerin_1; pfam00404 755731003151 Dockerin type I repeat; Region: Dockerin_1; pfam00404 755731003152 Penicillinase repressor; Region: Pencillinase_R; cl17580 755731003153 HEAT repeats; Region: HEAT_2; pfam13646 755731003154 Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805 755731003155 Pentapeptide repeats (9 copies); Region: Pentapeptide_4; pfam13599 755731003156 Pentapeptide repeats (9 copies); Region: Pentapeptide_4; pfam13599 755731003157 Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805 755731003158 Protein of unknown function (DUF2813); Region: DUF2813; pfam11398 755731003159 AAA domain; Region: AAA_21; pfam13304 755731003160 RT_Bac_retron_II: Reverse transcriptases (RTs) in bacterial retrotransposons or retrons. The polymerase reaction of this enzyme leads to the production of a unique RNA-DNA complex called msDNA (multicopy single-stranded (ss)DNA) in which a small ssDNA...; Region: RT_Bac_retron_II; cd03487 755731003161 Reverse transcriptase (RNA-dependent DNA polymerase); Region: RVT_1; pfam00078 755731003162 putative active site [active] 755731003163 putative NTP binding site [chemical binding]; other site 755731003164 putative nucleic acid binding site [nucleotide binding]; other site 755731003165 aspartyl-tRNA synthetase; Validated; Region: aspS; PRK00476 755731003166 EcAspRS_like_N: N-terminal, anticodon recognition domain of the type found in Escherichia coli aspartyl-tRNA synthetase (AspRS), the human mitochondrial (mt) AspRS-2, the discriminating (D) Thermus thermophilus AspRS-1, and the nondiscriminating (ND)...; Region: EcAspRS_like_N; cd04317 755731003167 dimer interface [polypeptide binding]; other site 755731003168 anticodon binding site; other site 755731003169 Asp tRNA synthetase (aspRS) class II core domain. Class II assignment is based upon its structure and the presence of three characteristic sequence motifs. AspRS is a homodimer, which attaches a specific amino acid to the 3' OH group of ribose of...; Region: AspRS_core; cd00777 755731003170 homodimer interface [polypeptide binding]; other site 755731003171 motif 1; other site 755731003172 active site 755731003173 motif 2; other site 755731003174 GAD domain; Region: GAD; pfam02938 755731003175 Class II tRNA amino-acyl synthetase-like catalytic core domain. Class II amino acyl-tRNA synthetases (aaRS) share a common fold and generally attach an amino acid to the 3' OH of ribose of the appropriate tRNA. PheRS is an exception in that it...; Region: class_II_aaRS-like_core; cl00268 755731003176 active site 755731003177 motif 3; other site 755731003178 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 755731003179 Transcriptional regulator C-terminal region; Region: TetR_C_8; pfam14278 755731003180 CotH protein; Region: CotH; pfam08757 755731003181 Polyphosphate(polyP) polymerase domain of yeast vacuolar transport chaperone (VTC) proteins VTC-2, -3 and- 4, and similar proteins; Region: PolyPPase_VTC_like; cd07750 755731003182 putative metal binding residues [ion binding]; other site 755731003183 signature motif; other site 755731003184 dimer interface [polypeptide binding]; other site 755731003185 active site 755731003186 polyP binding site; other site 755731003187 substrate binding site [chemical binding]; other site 755731003188 acceptor-phosphate pocket; other site 755731003189 PAP2_like_2 proteins. PAP2 is a super-family of phosphatases and haloperoxidases. This subgroup, which is specific to bacteria, lacks functional characterization and may act as a membrane-associated lipid phosphatase; Region: PAP2_like_2; cd03392 755731003190 active site 755731003191 Membrane-associated phospholipid phosphatase [Lipid metabolism]; Region: PgpB; COG0671 755731003192 undecaprenyl phosphate 4-deoxy-4-formamido-L-arabinose transferase; Provisional; Region: PRK10714 755731003193 Bacterial DPM1_like enzymes are related to eukaryotic DPM1; Region: DPM1_like_bac; cd04187 755731003194 Ligand binding site; other site 755731003195 Putative Catalytic site; other site 755731003196 DXD motif; other site 755731003197 thymidylate synthase; Reviewed; Region: thyA; PRK01827 755731003198 Thymidylate synthase and pyrimidine hydroxymethylase: Thymidylate synthase (TS) and deoxycytidylate hydroxymethylase (dCMP-HMase) are homologs that catalyze analogous alkylation of C5 of pyrimidine nucleotides. Both enzymes are involved in the...; Region: TS_Pyrimidine_HMase; cd00351 755731003199 dimerization interface [polypeptide binding]; other site 755731003200 active site 755731003201 Dihydrofolate reductase [Coenzyme metabolism]; Region: FolA; COG0262 755731003202 Dihydrofolate reductase (DHFR). Reduces 7,8-dihydrofolate to 5,6,7,8-tetrahydrofolate with NADPH as a cofactor. This is an essential step in the biosynthesis of deoxythymidine phosphate since 5,6,7,8-tetrahydrofolate is required to regenerate 5; Region: DHFR; cd00209 755731003203 folate binding site [chemical binding]; other site 755731003204 NADP+ binding site [chemical binding]; other site 755731003205 translation initiation factor IF-3; Reviewed; Region: infC; PRK00028 755731003206 Translation initiation factor IF-3, N-terminal domain; Region: IF3_N; pfam05198 755731003207 Translation initiation factor IF-3, C-terminal domain; Region: IF3_C; pfam00707 755731003208 50S ribosomal protein L35; Reviewed; Region: rpmI; PRK00172 755731003209 Ribosomal protein L20; Region: Ribosomal_L20; cd07026 755731003210 23S rRNA binding site [nucleotide binding]; other site 755731003211 L21 binding site [polypeptide binding]; other site 755731003212 L13 binding site [polypeptide binding]; other site 755731003213 DNA polymerase IV; Validated; Region: PRK01810 755731003214 DNA Polymerase IV/Kappa; Region: PolY_Pol_IV_kappa; cd03586 755731003215 active site 755731003216 DNA binding site [nucleotide binding] 755731003217 Flagellar protein YcgR; Region: YcgR_2; pfam12945 755731003218 PilZ domain; Region: PilZ; pfam07238 755731003219 Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: AGPAT-like; Region: LPLAT_AGPAT-like; cd07989 755731003220 1-acyl-sn-glycerol-3-phosphate acyltransferase [Lipid metabolism]; Region: PlsC; COG0204 755731003221 putative acyl-acceptor binding pocket; other site 755731003222 ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136 755731003223 ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255 755731003224 Walker A/P-loop; other site 755731003225 ATP binding site [chemical binding]; other site 755731003226 Q-loop/lid; other site 755731003227 ABC transporter signature motif; other site 755731003228 Walker B; other site 755731003229 D-loop; other site 755731003230 H-loop/switch region; other site 755731003231 FtsX-like permease family; Region: FtsX; pfam02687 755731003232 radical SAM family uncharacterized protein; Region: rSAM_fuse_unch; TIGR03960 755731003233 B12 binding domain (B12-BD). Most of the members bind different cobalamid derivates, like B12 (adenosylcobamide) or methylcobalamin or methyl-Co(III) 5-hydroxybenzimidazolylcobamide. This domain is found in several enzymes, such as glutamate mutase; Region: B12-binding_like; cl00293 755731003234 B12 binding site [chemical binding]; other site 755731003235 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 755731003236 FeS/SAM binding site; other site 755731003237 radical SAM-linked protein; Region: sam_1_link_chp; TIGR03936 755731003238 Uncharacterized protein conserved in bacteria (DUF2344); Region: DUF2344; pfam10105 755731003239 ribonuclease, Rne/Rng family; Region: RNaseEG; TIGR00757 755731003240 S1_RNase_E: RNase E and RNase G, S1-like RNA-binding domain. RNase E is an essential endoribonuclease in the processing and degradation of RNA. In addition to its role in mRNA degradation, RNase E has also been implicated in the processing of rRNA, and...; Region: S1_RNase_E; cd04453 755731003241 homodimer interface [polypeptide binding]; other site 755731003242 oligonucleotide binding site [chemical binding]; other site 755731003243 50S ribosomal protein L21/unknown domain fusion protein; Provisional; Region: PRK12278 755731003244 50S ribosomal protein L21; Validated; Region: rplU; PRK05573 755731003245 hypothetical protein; Provisional; Region: PRK14553 755731003246 50S ribosomal protein L27; Validated; Region: rpmA; PRK05435 755731003247 GTPase CgtA; Reviewed; Region: obgE; PRK12297 755731003248 GTP1/OBG; Region: GTP1_OBG; pfam01018 755731003249 Obg GTPase; Region: Obg; cd01898 755731003250 G1 box; other site 755731003251 GTP/Mg2+ binding site [chemical binding]; other site 755731003252 Switch I region; other site 755731003253 G2 box; other site 755731003254 G3 box; other site 755731003255 Switch II region; other site 755731003256 G4 box; other site 755731003257 G5 box; other site 755731003258 Domain of unknown function (DUF1967); Region: DUF1967; pfam09269 755731003259 Predicted RNA-binding protein containing KH domain, possibly ribosomal protein [Translation, ribosomal structure and biogenesis]; Region: COG1534 755731003260 Domain of unknown function (DUF4364); Region: DUF4364; pfam14277 755731003261 Reductive dehalogenase subunit; Region: Dehalogenase; pfam13486 755731003262 4Fe-4S double cluster binding domain; Region: Fer4_16; pfam13484 755731003263 GTP cyclohydrolase I; Provisional; Region: folE; PRK09347 755731003264 active site 755731003265 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 755731003266 Zn2+ binding site [ion binding]; other site 755731003267 Mg2+ binding site [ion binding]; other site 755731003268 DHPS subgroup of Pterin binding enzymes. DHPS (dihydropteroate synthase), a functional homodimer, catalyzes the condensation of p-aminobenzoic acid (pABA) in the de novo biosynthesis of folate, which is an essential cofactor in both nucleic acid and...; Region: DHPS; cd00739 755731003269 dihydropteroate synthase; Region: DHPS; TIGR01496 755731003270 substrate binding pocket [chemical binding]; other site 755731003271 dimer interface [polypeptide binding]; other site 755731003272 inhibitor binding site; inhibition site 755731003273 Dihydroneopterin aldolase (DHNA) and 7,8-dihydroneopterin triphosphate epimerase domain (DHNTPE); these enzymes have been designated folB and folX, respectively. Folate derivatives are essential cofactors in the biosynthesis of purines, pyrimidines, and...; Region: DHNA_DHNTPE; cd00534 755731003274 homooctamer interface [polypeptide binding]; other site 755731003275 active site 755731003276 7,8-dihydro-6-hydroxymethylpterin-pyrophosphokinase (HPPK). Folate derivatives are essential cofactors in the biosynthesis of purines, pyrimidines, and amino acids as well as formyl-tRNA. Mammalian cells are able to utilize pre-formed folates after...; Region: HPPK; cd00483 755731003277 catalytic center binding site [active] 755731003278 ATP binding site [chemical binding]; other site 755731003279 ATP:corrinoid adenosyltransferase BtuR/CobO/CobP; Region: CobA_CobO_BtuR; pfam02572 755731003280 glycogen synthase; Provisional; Region: glgA; PRK00654 755731003281 This family is most closely related to the GT1 family of glycosyltransferases. Glycogen synthase catalyzes the formation and elongation of the alpha-1,4-glucose backbone using ADP-glucose, the second and key step of glycogen biosynthesis. This family...; Region: GT1_Glycogen_synthase_DULL1_like; cd03791 755731003282 ADP-binding pocket [chemical binding]; other site 755731003283 homodimer interface [polypeptide binding]; other site 755731003284 TSCPD domain; Region: TSCPD; cl14834 755731003285 YtxH-like protein; Region: YtxH; pfam12732 755731003286 Serine/threonine phosphatases, family 2C, catalytic domain; The protein architecture and deduced catalytic mechanism of PP2C phosphatases are similar to the PP1, PP2A, PP2B family of protein Ser/Thr phosphatases, with which PP2C shares no sequence...; Region: PP2Cc; cl00120 755731003287 Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118 755731003288 Stress responsive A/B Barrel Domain; Region: Dabb; smart00886 755731003289 Putative catalytic NodB homology domain of uncharacterized bacterial polysaccharide deacetylases which consist of a 5-stranded beta/alpha barrel; Region: CE4_DAC_u3_5s; cd10972 755731003290 putative active site [active] 755731003291 putative metal binding site [ion binding]; other site 755731003292 argininosuccinate lyase; Provisional; Region: PRK00855 755731003293 Argininosuccinate lyase (argininosuccinase, ASAL); Region: Argininosuccinate_lyase; cd01359 755731003294 active sites [active] 755731003295 tetramer interface [polypeptide binding]; other site 755731003296 argininosuccinate synthase; Provisional; Region: PRK13820 755731003297 Argininosuccinate synthase. The Argininosuccinate synthase is a urea cycle enzyme that catalyzes the penultimate step in arginine biosynthesis: the ATP-dependent ligation of citrulline to aspartate to form argininosuccinate, AMP and pyrophosphate . In...; Region: Argininosuccinate_Synthase; cd01999 755731003298 ANP binding site [chemical binding]; other site 755731003299 Substrate Binding Site II [chemical binding]; other site 755731003300 Substrate Binding Site I [chemical binding]; other site 755731003301 Holliday junction resolvases (HJRs) are endonucleases that specifically resolve Holliday junction DNA intermediates during homologous recombination. HJR's occur in archaea, bacteria, and in the mitochondria of certain fungi, however this CD...; Region: RuvC_resolvase; cd00529 755731003302 active site 755731003303 putative DNA-binding cleft [nucleotide binding]; other site 755731003304 dimer interface [polypeptide binding]; other site 755731003305 Holliday junction DNA helicase RuvA; Reviewed; Region: ruvA; PRK00116 755731003306 RuvA N terminal domain; Region: RuvA_N; pfam01330 755731003307 RuvA, C-terminal domain; Region: RuvA_C; pfam07499 755731003308 Holliday junction DNA helicase RuvB; Reviewed; Region: ruvB; PRK00080 755731003309 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 755731003310 Walker A motif; other site 755731003311 ATP binding site [chemical binding]; other site 755731003312 Walker B motif; other site 755731003313 arginine finger; other site 755731003314 Holliday junction DNA helicase ruvB C-terminus; Region: RuvB_C; pfam05491 755731003315 Adenine nucleotide alpha hydrolases superfamily including N type ATP PPases and ATP sulphurylases. The domain forms a apha/beta/apha fold which binds to Adenosine group; Region: Alpha_ANH_like; cd01986 755731003316 Ligand Binding Site [chemical binding]; other site 755731003317 Copper amine oxidase N-terminal domain; Region: Cu_amine_oxidN1; pfam07833 755731003318 Copper amine oxidase N-terminal domain; Region: Cu_amine_oxidN1; pfam07833 755731003319 N-acetylmuramoyl-L-alanine amidase [Cell envelope biogenesis, outer membrane]; Region: AmiC; COG0860 755731003320 N-acetylmuramoyl-L-alanine amidase or MurNAc-LAA (also known as peptidoglycan aminohydrolase, NAMLA amidase, NAMLAA, Amidase 3, and peptidoglycan amidase; EC 3.5.1.28) is an autolysin that hydrolyzes the amide bond between N-acetylmuramoyl and L-amino...; Region: MurNAc-LAA; cd02696 755731003321 active site 755731003322 metal binding site [ion binding]; metal-binding site 755731003323 Sporulation and spore germination; Region: Germane; pfam10646 755731003324 Sporulation and spore germination; Region: Germane; pfam10646 755731003325 ribonuclease PH; Reviewed; Region: rph; PRK00173 755731003326 Ribonuclease PH; Region: RNase_PH_bact; cd11362 755731003327 hexamer interface [polypeptide binding]; other site 755731003328 active site 755731003329 NTPase/HAM1. This family consists of the HAM1 protein and pyrophosphate-releasing xanthosine/ inosine triphosphatase. HAM1 protects the cell against mutagenesis by the base analog 6-N-hydroxylaminopurine (HAP) in E. Coli and S. cerevisiae. A...; Region: HAM1; cd00515 755731003330 active site 755731003331 dimerization interface [polypeptide binding]; other site 755731003332 Escherichia coli YfcE and related proteins, metallophosphatase domain; Region: MPP_YfcE; cd00841 755731003333 Calcineurin-like phosphoesterase; Region: Metallophos; pfam00149 755731003334 active site 755731003335 metal binding site [ion binding]; metal-binding site 755731003336 homotetramer interface [polypeptide binding]; other site 755731003337 Protein of unknown function (DUF2971); Region: DUF2971; pfam11185 755731003338 Cell Wall Hydrolase; Region: Hydrolase_2; pfam07486 755731003339 5'-methylthioadenosine/S-adenosylhomocysteine nucleosidase; Validated; Region: PRK05584 755731003340 5'-methylthioadenosine/S-adenosylhomocysteine nucleosidase; Region: MTA/SAH-Nsdase; TIGR01704 755731003341 4Fe-4S binding domain; Region: Fer4_6; pfam12837 755731003342 4Fe-4S dicluster domain; Region: Fer4_7; pfam12838 755731003343 effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038 755731003344 global nitrogen regulator NtcA, cyanobacterial; Region: NtcA_cyano; TIGR03697 755731003345 ligand binding site [chemical binding]; other site 755731003346 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 755731003347 putative Zn2+ binding site [ion binding]; other site 755731003348 putative DNA binding site [nucleotide binding]; other site 755731003349 A subgroup of the band 7 domain of flotillin (reggie) like proteins. This subgroup contains proteins similar to stomatin, prohibitin, flotillin, HlfK/C and podicin. Many of these band 7 domain-containing proteins are lipid raft-associated. Individual...; Region: Band_7_2; cd03402 755731003350 Membrane protease subunits, stomatin/prohibitin homologs [Posttranslational modification, protein turnover, chaperones]; Region: HflC; COG0330 755731003351 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4877 755731003352 nicotinic acid mononucleotide adenylyltransferase; Provisional; Region: nadD; PRK00071 755731003353 Nicotinamide/nicotinate mononucleotide adenylyltransferase; Region: NMNAT; cd02165 755731003354 active site 755731003355 (T/H)XGH motif; other site 755731003356 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 755731003357 Zn2+ binding site [ion binding]; other site 755731003358 Mg2+ binding site [ion binding]; other site 755731003359 LytR cell envelope-related transcriptional attenuator; Region: LytR_C; pfam13399 755731003360 iojap-like ribosome-associated protein; Region: iojap_ybeB; TIGR00090 755731003361 ABC transporter ATP-binding protein; Provisional; Region: PRK15064 755731003362 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 755731003363 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 755731003364 Walker A/P-loop; other site 755731003365 ATP binding site [chemical binding]; other site 755731003366 Q-loop/lid; other site 755731003367 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 755731003368 ABC transporter signature motif; other site 755731003369 Walker B; other site 755731003370 D-loop; other site 755731003371 ABC transporter; Region: ABC_tran_2; pfam12848 755731003372 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 755731003373 A predicted NlpC/p60-like peptidase; Region: BtrH; pfam14399 755731003374 Long-chain acyl-CoA synthetases (AMP-forming) [Lipid metabolism]; Region: FAA1; COG1022 755731003375 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 755731003376 Long-chain fatty acid CoA synthetases and Bubblegum-like very long-chain fatty acid CoA synthetases; Region: VL_LC_FACS_like; cd05907 755731003377 acyl-activating enzyme (AAE) consensus motif; other site 755731003378 acyl-activating enzyme (AAE) consensus motif; other site 755731003379 putative AMP binding site [chemical binding]; other site 755731003380 putative active site [active] 755731003381 putative CoA binding site [chemical binding]; other site 755731003382 D-alanyl-D-alanine carboxypeptidase [Cell envelope biogenesis, outer membrane]; Region: DacC; COG1686 755731003383 Beta-lactamase enzyme family; Region: Beta-lactamase2; cl17872 755731003384 Penicillin-binding protein 5, C-terminal domain; Region: PBP5_C; smart00936 755731003385 SLBB domain; Region: SLBB; pfam10531 755731003386 comEA protein; Region: comE; TIGR01259 755731003387 Helix-hairpin-helix motif; Region: HHH; pfam00633 755731003388 threonyl-tRNA synthetase; Reviewed; Region: thrS; PRK00413 755731003389 TGS _ThrRS_N: ThrRS (threonyl-tRNA Synthetase) is a class II tRNA synthetase that couples threonine to its cognate tRNA. In addition to its catalytic and anticodon-binding domains, ThrRS has an N-terminal TGS domain, named after the ThrRS, GTPase, and...; Region: TGS_ThrRS_N; cd01667 755731003390 Threonyl and Alanyl tRNA synthetase second additional domain; Region: tRNA_SAD; smart00863 755731003391 Threonyl-tRNA synthetase (ThrRS) class II core catalytic domain. ThrRS is a homodimer. It is responsible for the attachment of threonine to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for ATP-dependent...; Region: ThrRS_core; cd00771 755731003392 active site 755731003393 dimer interface [polypeptide binding]; other site 755731003394 motif 1; other site 755731003395 motif 2; other site 755731003396 motif 3; other site 755731003397 ThrRS Threonyl-anticodon binding domain. ThrRS belongs to class II aminoacyl-tRNA synthetases (aaRS). This alignment contains the anticodon binding domain, which is responsible for specificity in tRNA-binding, so that the activated amino acid is...; Region: ThrRS_anticodon; cd00860 755731003398 anticodon binding site; other site 755731003399 threonyl-tRNA synthetase; Reviewed; Region: thrS; PRK00413 755731003400 TGS _ThrRS_N: ThrRS (threonyl-tRNA Synthetase) is a class II tRNA synthetase that couples threonine to its cognate tRNA. In addition to its catalytic and anticodon-binding domains, ThrRS has an N-terminal TGS domain, named after the ThrRS, GTPase, and...; Region: TGS_ThrRS_N; cd01667 755731003401 Threonyl and Alanyl tRNA synthetase second additional domain; Region: tRNA_SAD; pfam07973 755731003402 Threonyl-tRNA synthetase (ThrRS) class II core catalytic domain. ThrRS is a homodimer. It is responsible for the attachment of threonine to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for ATP-dependent...; Region: ThrRS_core; cd00771 755731003403 active site 755731003404 dimer interface [polypeptide binding]; other site 755731003405 motif 1; other site 755731003406 motif 2; other site 755731003407 motif 3; other site 755731003408 ThrRS Threonyl-anticodon binding domain. ThrRS belongs to class II aminoacyl-tRNA synthetases (aaRS). This alignment contains the anticodon binding domain, which is responsible for specificity in tRNA-binding, so that the activated amino acid is...; Region: ThrRS_anticodon; cd00860 755731003409 anticodon binding site; other site 755731003410 S-layer homology domain; Region: SLH; pfam00395 755731003411 S-layer homology domain; Region: SLH; pfam00395 755731003412 S-layer homology domain; Region: SLH; pfam00395 755731003413 Copper amine oxidase N-terminal domain; Region: Cu_amine_oxidN1; pfam07833 755731003414 Predicted transcriptional regulators [Transcription]; Region: COG1695 755731003415 Transcriptional regulator PadR-like family; Region: PadR; cl17335 755731003416 Virulence activator alpha C-term; Region: Vir_act_alpha_C; pfam10400 755731003417 Metallo-beta-lactamase superfamily; Region: Lactamase_B; smart00849 755731003418 GAF domain-containing protein [Signal transduction mechanisms]; Region: COG1956 755731003419 GAF domain; Region: GAF_2; pfam13185 755731003420 NfeD-like C-terminal, partner-binding; Region: NfeD; cl00686 755731003421 Band_7_flotillin: a subgroup of the band 7 domain of flotillin (reggie) like proteins. This subgroup contains proteins similar to stomatin, prohibitin, flotillin, HlfK/C and podicin. These two proteins are lipid raft-associated. Individual proteins of...; Region: Band_7_flotillin; cd03399 755731003422 The band 7 domain of flotillin (reggie) like proteins. This group contains proteins similar to stomatin, prohibitin, flotillin, HlfK/C and podicin. Many of these band 7 domain-containing proteins are lipid raft-associated. Individual proteins of this...; Region: Band_7; cl02525 755731003423 Four helix bundle sensory module for signal transduction; Region: 4HB_MCP_1; pfam12729 755731003424 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 755731003425 dimerization interface [polypeptide binding]; other site 755731003426 Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer); Region: MA; smart00283 755731003427 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 755731003428 dimer interface [polypeptide binding]; other site 755731003429 putative CheW interface [polypeptide binding]; other site 755731003430 ATPase components of ABC transporters with duplicated ATPase domains [General function prediction only]; Region: Uup; COG0488 755731003431 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 755731003432 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 755731003433 ABC transporter; Region: ABC_tran_2; pfam12848 755731003434 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 755731003435 Response regulator receiver domain; Region: Response_reg; pfam00072 755731003436 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 755731003437 active site 755731003438 phosphorylation site [posttranslational modification] 755731003439 intermolecular recognition site; other site 755731003440 dimerization interface [polypeptide binding]; other site 755731003441 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 755731003442 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 755731003443 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 755731003444 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 755731003445 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 755731003446 dimerization interface [polypeptide binding]; other site 755731003447 Histidine kinase; Region: His_kinase; pfam06580 755731003448 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 755731003449 ATP binding site [chemical binding]; other site 755731003450 Mg2+ binding site [ion binding]; other site 755731003451 G-X-G motif; other site 755731003452 S-layer homology domain; Region: SLH; pfam00395 755731003453 S-layer homology domain; Region: SLH; pfam00395 755731003454 S-layer homology domain; Region: SLH; pfam00395 755731003455 ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653 755731003456 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; pfam01547 755731003457 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 755731003458 dimer interface [polypeptide binding]; other site 755731003459 conserved gate region; other site 755731003460 putative PBP binding loops; other site 755731003461 ABC-ATPase subunit interface; other site 755731003462 ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395 755731003463 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 755731003464 dimer interface [polypeptide binding]; other site 755731003465 conserved gate region; other site 755731003466 putative PBP binding loops; other site 755731003467 ABC-ATPase subunit interface; other site 755731003468 Trehalose and maltose hydrolases (possible phosphorylases) [Carbohydrate transport and metabolism]; Region: ATH1; COG1554 755731003469 Glycosyl hydrolase family 65, N-terminal domain; Region: Glyco_hydro_65N; pfam03636 755731003470 Glycosyl hydrolase family 65 central catalytic domain; Region: Glyco_hydro_65m; pfam03632 755731003471 beta-phosphoglucomutase; Region: bPGM; TIGR01990 755731003472 haloacid dehalogenase-like hydrolase; Region: HAD; cl17202 755731003473 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 755731003474 motif II; other site 755731003475 aldose 1-epimerase superfamily; Region: Aldose_epim; cl14648 755731003476 active site 755731003477 catalytic residues [active] 755731003478 Glycosyl hydrolase family 43; Region: GH43_1; cd08980 755731003479 active site 755731003480 Carbohydrate Binding Module 6 (CBM6) and CBM35_like superfamily; Region: CBM6-CBM35-CBM36_like; cl14880 755731003481 metal binding site [ion binding]; metal-binding site 755731003482 Carbohydrate Binding Module 6 (CBM6) domains; many are found in association with discoidin domain(s); Region: CBM6_discoidin-like; cd04083 755731003483 putative metal binding site [ion binding]; other site 755731003484 Carbohydrate Binding Module 6 (CBM6) domains; many are found in association with discoidin domain(s); Region: CBM6_discoidin-like; cd04083 755731003485 putative metal binding site [ion binding]; other site 755731003486 Carbohydrate Binding Module 6 (CBM6) domains; many are found in association with discoidin domain(s); Region: CBM6_discoidin-like; cd04083 755731003487 putative metal binding site [ion binding]; other site 755731003488 Ricin-type beta-trefoil lectin domain; Region: Ricin_B_lectin; pfam00652 755731003489 Ricin-type beta-trefoil; Carbohydrate-binding domain formed from presumed gene triplication. The domain is found in a variety of molecules serving diverse functions such as enzymatic activity, inhibitory toxicity and signal transduction. Highly specific...; Region: RICIN; cd00161 755731003490 putative sugar binding sites [chemical binding]; other site 755731003491 Q-X-W motif; other site 755731003492 Carbohydrate binding domain X2; Region: CBM_X2; pfam03442 755731003493 S-layer homology domain; Region: SLH; pfam00395 755731003494 S-layer homology domain; Region: SLH; pfam00395 755731003495 S-layer homology domain; Region: SLH; pfam00395 755731003496 galactose-1-phosphate uridylyltransferase; Provisional; Region: PRK05270 755731003497 Galactose-1-phosphate uridyl transferase, N-terminal domain; Region: GalP_UDP_transf; pfam01087 755731003498 Galactose-1-phosphate uridyl transferase, C-terminal domain; Region: GalP_UDP_tr_C; pfam02744 755731003499 galactokinase; Provisional; Region: PRK05322 755731003500 Galactokinase galactose-binding signature; Region: GalKase_gal_bdg; pfam10509 755731003501 GHMP kinases N terminal domain; Region: GHMP_kinases_N; pfam00288 755731003502 GHMP kinases C terminal; Region: GHMP_kinases_C; pfam08544 755731003503 UDP-glucose 4-epimerase [Cell envelope biogenesis, outer membrane]; Region: GalE; COG1087 755731003504 UDP-glucose 4 epimerase, subgroup 1, extended (e) SDRs; Region: UDP_G4E_1_SDR_e; cd05247 755731003505 NAD binding site [chemical binding]; other site 755731003506 homodimer interface [polypeptide binding]; other site 755731003507 active site 755731003508 substrate binding site [chemical binding]; other site 755731003509 helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347 755731003510 MarR family; Region: MarR_2; pfam12802 755731003511 ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132 755731003512 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 755731003513 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 755731003514 Walker A/P-loop; other site 755731003515 ATP binding site [chemical binding]; other site 755731003516 Q-loop/lid; other site 755731003517 ABC transporter signature motif; other site 755731003518 Walker B; other site 755731003519 D-loop; other site 755731003520 H-loop/switch region; other site 755731003521 ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132 755731003522 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 755731003523 ATP-binding cassette domain of glucan transporter and related proteins, subfamily C; Region: ABCC_Glucan_exporter_like; cd03254 755731003524 Walker A/P-loop; other site 755731003525 ATP binding site [chemical binding]; other site 755731003526 Q-loop/lid; other site 755731003527 ABC transporter signature motif; other site 755731003528 Walker B; other site 755731003529 D-loop; other site 755731003530 H-loop/switch region; other site 755731003531 Protein of unknown function (DUF1653); Region: DUF1653; pfam07866 755731003532 Nitrogen regulatory protein PII [Amino acid transport and metabolism]; Region: GlnK; COG0347 755731003533 Nitrogen regulatory protein P-II; Region: P-II; smart00938 755731003534 indolepyruvate ferredoxin oxidoreductase, alpha subunit; Region: IOR_alpha; TIGR03336 755731003535 Pyrimidine (PYR) binding domain of pyruvate ferredoxin oxidoreductase (PFOR), indolepyruvate ferredoxin oxidoreductase alpha subunit (IOR-alpha), and related proteins; Region: TPP_PYR_PFOR_IOR-alpha_like; cd07034 755731003536 dimer interface [polypeptide binding]; other site 755731003537 PYR/PP interface [polypeptide binding]; other site 755731003538 TPP binding site [chemical binding]; other site 755731003539 substrate binding site [chemical binding]; other site 755731003540 Thiamine pyrophosphate (TPP) family, IOR-alpha subfamily, TPP-binding module; composed of proteins similar to indolepyruvate ferredoxin oxidoreductase (IOR) alpha subunit. IOR catalyzes the oxidative decarboxylation of arylpyruvates, such as...; Region: TPP_IOR_alpha; cd02008 755731003541 TPP-binding site; other site 755731003542 4Fe-4S binding domain; Region: Fer4_6; pfam12837 755731003543 indolepyruvate oxidoreductase subunit beta; Reviewed; Region: PRK06853 755731003544 pyruvate/ketoisovalerate ferredoxin oxidoreductase subunit gamma; Provisional; Region: PRK14029 755731003545 Methylglyoxal synthase catalyzes the enolization of dihydroxyacetone phosphate (DHAP) to produce methylglyoxal. The first part of the catalytic mechanism is believed to be similar to TIM (triosephosphate isomerase) in that both enzymes utilize DHAP to...; Region: MGS; cd01422 755731003546 active site 755731003547 dimer interfaces [polypeptide binding]; other site 755731003548 catalytic residues [active] 755731003549 Coenzyme F390 synthetase [Coenzyme metabolism]; Region: PaaK; COG1541 755731003550 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 755731003551 acyl-activating enzyme (AAE) consensus motif; other site 755731003552 AMP binding site [chemical binding]; other site 755731003553 active site 755731003554 CoA binding site [chemical binding]; other site 755731003555 The biotinyl-domain or biotin carboxyl carrier protein (BCCP) domain is present in all biotin-dependent enzymes, such as acetyl-CoA carboxylase, pyruvate carboxylase, propionyl-CoA carboxylase, methylcrotonyl-CoA carboxylase, geranyl-CoA carboxylase; Region: biotinyl_domain; cd06850 755731003556 carboxyltransferase (CT) interaction site; other site 755731003557 biotinylation site [posttranslational modification]; other site 755731003558 HlyD family secretion protein; Region: HlyD_3; pfam13437 755731003559 The biotinyl-domain or biotin carboxyl carrier protein (BCCP) domain is present in all biotin-dependent enzymes, such as acetyl-CoA carboxylase, pyruvate carboxylase, propionyl-CoA carboxylase, methylcrotonyl-CoA carboxylase, geranyl-CoA carboxylase; Region: biotinyl_domain; cd06850 755731003560 carboxyltransferase (CT) interaction site; other site 755731003561 biotinylation site [posttranslational modification]; other site 755731003562 HlyD family secretion protein; Region: HlyD_3; pfam13437 755731003563 ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136 755731003564 ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255 755731003565 Walker A/P-loop; other site 755731003566 ATP binding site [chemical binding]; other site 755731003567 Q-loop/lid; other site 755731003568 ABC transporter signature motif; other site 755731003569 Walker B; other site 755731003570 D-loop; other site 755731003571 H-loop/switch region; other site 755731003572 MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704 755731003573 ABC-type antimicrobial peptide transport system, permease component [Defense mechanisms]; Region: SalY; COG0577 755731003574 FtsX-like permease family; Region: FtsX; pfam02687 755731003575 S-layer homology domain; Region: SLH; pfam00395 755731003576 Protein of unknown function (DUF3243); Region: DUF3243; pfam11588 755731003577 FMN-binding domain; Region: FMN_bind; cl01081 755731003578 ECF-type riboflavin transporter, S component; Region: ECF-ribofla_trS; cl17272 755731003579 Protein of unknown function (DUF3816); Region: DUF3816; pfam12822 755731003580 DNA topoisomerase IV subunit B; Reviewed; Region: PRK05559 755731003581 DNA gyrase B; Region: DNA_gyraseB; pfam00204 755731003582 ATP binding site [chemical binding]; other site 755731003583 Topoisomerase-primase domain. This is a nucleotidyl transferase/hydrolase domain found in type IA, type IIA and type IIB topoisomerases, bacterial DnaG-type primases, small primase-like proteins from bacteria and archaea, OLD family nucleases from...; Region: TOPRIM; cl00718 755731003584 active site 755731003585 metal binding site [ion binding]; metal-binding site 755731003586 DNA gyrase B subunit, carboxyl terminus; Region: DNA_gyraseB_C; pfam00986 755731003587 DNA topoisomerase IV subunit A; Validated; Region: PRK05561 755731003588 DNA Topoisomerase, subtype IIA; domain A'; bacterial DNA topoisomerase IV (C subunit, ParC), bacterial DNA gyrases (A subunit, GyrA),mammalian DNA toposiomerases II. DNA topoisomerases are essential enzymes that regulate the conformational changes...; Region: TOP4c; cd00187 755731003589 CAP-like domain; other site 755731003590 active site 755731003591 primary dimer interface [polypeptide binding]; other site 755731003592 conserved hypothetical integral membrane protein; Region: TIGR03766 755731003593 cyclophilin: cyclophilin-type peptidylprolyl cis- trans isomerases. This family contains eukaryotic, bacterial and archeal proteins which exhibit a peptidylprolyl cis- trans isomerases activity (PPIase, Rotamase) and in addition bind the...; Region: cyclophilin; cd00317 755731003594 active site 755731003595 Uncharacterized FAD-dependent dehydrogenases [General function prediction only]; Region: COG2509 755731003596 hydroxyglutarate oxidase; Provisional; Region: PRK11728 755731003597 ubiquinone biosynthesis hydroxylase family protein; Provisional; Region: PRK07608; cl17314 755731003598 QueT transporter; Region: QueT; pfam06177 755731003599 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 755731003600 active site 755731003601 Uncharacterized ABC-type transport system, periplasmic component/surface lipoprotein [General function prediction only]; Region: Med; COG1744 755731003602 Periplasmic binding domain of the basic membrane lipoprotein Med in Bacillus and its close homologs from other bacteria and Archaea; Region: PBP1_BmpA_Med_like; cd06353 755731003603 putative ligand binding site [chemical binding]; other site 755731003604 ABC-type uncharacterized transport systems, ATPase components [General function prediction only]; Region: COG3845 755731003605 First domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_I; cd03216 755731003606 Walker A/P-loop; other site 755731003607 ATP binding site [chemical binding]; other site 755731003608 Q-loop/lid; other site 755731003609 ABC transporter signature motif; other site 755731003610 Walker B; other site 755731003611 D-loop; other site 755731003612 H-loop/switch region; other site 755731003613 Second domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_II; cd03215 755731003614 Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653 755731003615 Transmembrane subunit (TM) of Treponema pallidum (Tp) RbsC-1, RbsC-2 and related proteins. This is a functionally uncharacterized subgroup of TMs which belong to a larger group of TMs of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette; Region: TM_PBP1_transp_TpRbsC_like; cd06580 755731003616 TM-ABC transporter signature motif; other site 755731003617 Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653 755731003618 Transmembrane subunit (TM) of Treponema pallidum (Tp) RbsC-1, RbsC-2 and related proteins. This is a functionally uncharacterized subgroup of TMs which belong to a larger group of TMs of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette; Region: TM_PBP1_transp_TpRbsC_like; cd06580 755731003619 TM-ABC transporter signature motif; other site 755731003620 tryptophanyl-tRNA synthetase II; Reviewed; Region: PRK12282 755731003621 catalytic core domain of tryptophanyl-tRNA synthetase; Region: TrpRS_core; cd00806 755731003622 active site 755731003623 HIGH motif; other site 755731003624 dimer interface [polypeptide binding]; other site 755731003625 KMSKS motif; other site 755731003626 Predicted membrane protein [Function unknown]; Region: COG1971 755731003627 Domain of unknown function DUF; Region: DUF204; pfam02659 755731003628 excinuclease ABC subunit B; Provisional; Region: PRK05298 755731003629 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 755731003630 ATP binding site [chemical binding]; other site 755731003631 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 755731003632 nucleotide binding region [chemical binding]; other site 755731003633 ATP-binding site [chemical binding]; other site 755731003634 Ultra-violet resistance protein B; Region: UvrB; pfam12344 755731003635 UvrB/uvrC motif; Region: UVR; pfam02151 755731003636 LrgA family; Region: LrgA; pfam03788 755731003637 Putative effector of murein hydrolase [Cell envelope biogenesis, outer membrane]; Region: LrgB; COG1346 755731003638 phosphoglucomutase-2-like protein; Provisional; Region: PTZ00150 755731003639 This CD includes PGM2 (phosphoglucomutase 2) and PGM2L1 (phosphoglucomutase 2-like 1). The mammalian PGM2 is thought to be a phosphopentomutase that catalyzes the conversion of the nucleoside breakdown products, ribose-1-phosphate and...; Region: PGM2; cd05799 755731003640 active site 755731003641 substrate binding site [chemical binding]; other site 755731003642 metal binding site [ion binding]; metal-binding site 755731003643 Bacillus subtilis YkuE and related proteins, C-terminal metallophosphatase domain; Region: MPP_YkuE_C; cd07385 755731003644 Calcineurin-like phosphoesterase; Region: Metallophos; pfam00149 755731003645 putative active site [active] 755731003646 putative metal binding site [ion binding]; other site 755731003647 MoCF_BD: molybdenum cofactor (MoCF) binding domain (BD). This domain is found a variety of proteins involved in biosynthesis of molybdopterin cofactor, like MoaB, MogA, and MoeA. The domain is presumed to bind molybdopterin; Region: MoCF_BD; cl00451 755731003648 c-di-GMP phosphodiesterase class II (HD-GYP domain) [Signal transduction mechanisms]; Region: COG2206 755731003649 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 755731003650 Zn2+ binding site [ion binding]; other site 755731003651 Mg2+ binding site [ion binding]; other site 755731003652 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 755731003653 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 755731003654 non-specific DNA binding site [nucleotide binding]; other site 755731003655 salt bridge; other site 755731003656 sequence-specific DNA binding site [nucleotide binding]; other site 755731003657 Helix-turn-helix domain; Region: HTH_19; pfam12844 755731003658 non-specific DNA binding site [nucleotide binding]; other site 755731003659 salt bridge; other site 755731003660 sequence-specific DNA binding site [nucleotide binding]; other site 755731003661 Accessory gene regulator B; Region: AgrB; pfam04647 755731003662 Site-specific recombinase XerD [DNA replication, recombination, and repair]; Region: XerD; COG4974 755731003663 DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213 755731003664 active site 755731003665 DNA binding site [nucleotide binding] 755731003666 Int/Topo IB signature motif; other site 755731003667 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 755731003668 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 755731003669 non-specific DNA binding site [nucleotide binding]; other site 755731003670 salt bridge; other site 755731003671 sequence-specific DNA binding site [nucleotide binding]; other site 755731003672 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cl17200 755731003673 non-specific DNA binding site [nucleotide binding]; other site 755731003674 salt bridge; other site 755731003675 sequence-specific DNA binding site [nucleotide binding]; other site 755731003676 SpoVT / AbrB like domain; Region: SpoVT_AbrB; smart00966 755731003677 GIY-YIG nuclease domain superfamily; Region: GIY-YIG_SF; cl15257 755731003678 GIY-YIG motif/motif A; other site 755731003679 active site 755731003680 catalytic site [active] 755731003681 Domain of unknown function (DUF4373); Region: DUF4373; pfam14297 755731003682 Cytosine-C5 specific DNA methylases; Methyl transfer reactions play an important role in many aspects of biology. Cytosine-specific DNA methylases are found both in prokaryotes and eukaryotes. DNA methylation, or the covalent addition of a methyl group...; Region: Cyt_C5_DNA_methylase; cd00315 755731003683 cofactor binding site; other site 755731003684 DNA binding site [nucleotide binding] 755731003685 substrate interaction site [chemical binding]; other site 755731003686 Radical SAM superfamily; Region: Radical_SAM; pfam04055 755731003687 DNA modification methylase [DNA replication, recombination, and repair]; Region: COG0863 755731003688 DNA methylase; Region: N6_N4_Mtase; pfam01555 755731003689 Domain of Unknown Function (DUF1599); Region: DUF1599; pfam07659 755731003690 YopX protein; Region: YopX; pfam09643 755731003691 Nucleoside Triphosphate Pyrophosphohydrolase (EC 3.6.1.8) MazG-like domain found in a group of uncharacterized proteins from bacteria and archaea; Region: NTP-PPase_u5; cd11542 755731003692 metal binding site [ion binding]; metal-binding site 755731003693 DNA binding residues [nucleotide binding] 755731003694 Sigma-70, region 4; Region: Sigma70_r4_2; pfam08281 755731003695 DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213 755731003696 active site 755731003697 DNA binding site [nucleotide binding] 755731003698 Int/Topo IB signature motif; other site 755731003699 HNH nucleases; HNH endonuclease signature which is found in viral, prokaryotic, and eukaryotic proteins. The alignment includes members of the large group of homing endonucleases, yeast intron 1 protein, MutS, as well as bacterial colicins, pyocins, and...; Region: HNHc; cl00083 755731003700 Phage terminase, small subunit; Region: Terminase_4; pfam05119 755731003701 Phage Terminase; Region: Terminase_1; pfam03354 755731003702 Phage portal protein; Region: Phage_portal; pfam04860 755731003703 Phage-related protein [Function unknown]; Region: COG4695; cl01923 755731003704 Caseinolytic protease (ClpP) is an ATP-dependent, highly conserved serine protease; Region: S14_ClpP_1; cd07016 755731003705 oligomer interface [polypeptide binding]; other site 755731003706 Clp protease; Region: CLP_protease; pfam00574 755731003707 active site residues [active] 755731003708 phage major capsid protein, HK97 family; Region: major_cap_HK97; TIGR01554 755731003709 Phage capsid family; Region: Phage_capsid; pfam05065 755731003710 Head-Tail Connector Protein gp6 of Bacteriophage HK97 and similar proteins; Region: gp6; cd08054 755731003711 oligomerization interface [polypeptide binding]; other site 755731003712 Phage head-tail joining protein; Region: Phage_H_T_join; pfam05521 755731003713 Bacteriophage protein of unknown function (DUF646); Region: DUF646; cl12124 755731003714 phage major tail protein, phi13 family; Region: maj_tail_phi13; TIGR01603 755731003715 tape measure domain; Region: tape_meas_nterm; TIGR02675 755731003716 Phage tail protein; Region: Sipho_tail; cl17486 755731003717 Prophage endopeptidase tail; Region: Prophage_tail; cl12123 755731003718 NlpC/P60 family; Region: NLPC_P60; cl17555 755731003719 Cell wall-associated hydrolases (invasion-associated proteins) [Cell envelope biogenesis, outer membrane]; Region: Spr; COG0791 755731003720 Protein of unknown function (DUF2971); Region: DUF2971; pfam11185 755731003721 Site-specific recombinases, DNA invertase Pin homologs [DNA replication, recombination, and repair]; Region: PinR; COG1961 755731003722 Serine Recombinase family, catalytic domain; a DNA binding domain may be present either N- or C-terminal to the catalytic domain. These enzymes perform site-specific recombination of DNA molecules by a concerted, four-strand cleavage and rejoining...; Region: Ser_Recombinase; cd00338 755731003723 catalytic residues [active] 755731003724 catalytic nucleophile [active] 755731003725 Recombinase; Region: Recombinase; pfam07508 755731003726 Recombinase zinc beta ribbon domain; Region: Zn_ribbon_recom; pfam13408 755731003727 Dynamin family; Region: Dynamin_N; pfam00350 755731003728 Rat sarcoma (Ras)-like superfamily of small guanosine triphosphatases (GTPases); Region: Ras_like_GTPase; cl17170 755731003729 G1 box; other site 755731003730 GTP/Mg2+ binding site [chemical binding]; other site 755731003731 G2 box; other site 755731003732 Switch I region; other site 755731003733 Rat sarcoma (Ras)-like superfamily of small guanosine triphosphatases (GTPases); Region: Ras_like_GTPase; cd00882 755731003734 G3 box; other site 755731003735 G3 box; other site 755731003736 Switch II region; other site 755731003737 Switch II region; other site 755731003738 GTP/Mg2+ binding site [chemical binding]; other site 755731003739 G4 box; other site 755731003740 G5 box; other site 755731003741 zinc-ribbon domain; Region: zf-ribbon_3; cl11198 755731003742 Predicted membrane protein [Function unknown]; Region: XynA; COG2314 755731003743 Membrane protease subunit, stomatin/prohibitin family [Amino acid transport and metabolism]; Region: COG4260 755731003744 The band 7 domain of flotillin (reggie) like proteins. This group contains proteins similar to stomatin, prohibitin, flotillin, HlfK/C and podicin. Many of these band 7 domain-containing proteins are lipid raft-associated. Individual proteins of this...; Region: Band_7; cl02525 755731003745 zinc-ribbon domain; Region: zf-ribbon_3; pfam13248 755731003746 zinc-ribbon domain; Region: zf-ribbon_3; pfam13248 755731003747 zinc-ribbon domain; Region: zf-ribbon_3; pfam13248 755731003748 cAMP-binding proteins - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases [Signal transduction mechanisms]; Region: Crp; COG0664 755731003749 effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038 755731003750 ligand binding site [chemical binding]; other site 755731003751 flexible hinge region; other site 755731003752 Crp-like helix-turn-helix domain; Region: HTH_Crp_2; pfam13545 755731003753 hybrid cluster protein; Provisional; Region: PRK05290 755731003754 Hybrid cluster protein (HCP), formerly known as prismane, is thought to play a role in nitrogen metabolism but its specific function is unknown. HCP has three structural domains, an N-terminal alpha-helical domain, and two similar domains comprising a...; Region: HCP; cd01914 755731003755 hybrid metal cluster; other site 755731003756 Large-conductance mechanosensitive channel [Cell envelope biogenesis, outer membrane]; Region: MscL; COG1970 755731003757 large-conductance mechanosensitive channel; Reviewed; Region: mscL; PRK00567 755731003758 Uncharacterized protein with SCP/PR1 domains [Function unknown]; Region: COG2340 755731003759 SCP_bacterial: SCP-like extracellular protein domain, as found in bacteria and archaea. The wider family of SCP containing proteins includes plant pathogenesis-related protein 1 (PR-1), CRISPs, mammalian cysteine-rich secretory proteins, and allergen 5...; Region: SCP_bacterial; cd05379 755731003760 Predicted divalent heavy-metal cations transporter [Inorganic ion transport and metabolism]; Region: COG0428 755731003761 AraC-like ligand binding domain; Region: AraC_binding; pfam02311 755731003762 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 755731003763 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 755731003764 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 755731003765 ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132 755731003766 ATP-binding cassette domain of the bacterial lipid flippase and related proteins, subfamily C; Region: ABCC_MsbA; cd03251 755731003767 Walker A/P-loop; other site 755731003768 ATP binding site [chemical binding]; other site 755731003769 Q-loop/lid; other site 755731003770 ABC transporter signature motif; other site 755731003771 Walker B; other site 755731003772 D-loop; other site 755731003773 H-loop/switch region; other site 755731003774 ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132 755731003775 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 755731003776 ATP-binding cassette domain of the bacterial lipid flippase and related proteins, subfamily C; Region: ABCC_MsbA; cd03251 755731003777 Walker A/P-loop; other site 755731003778 ATP binding site [chemical binding]; other site 755731003779 Q-loop/lid; other site 755731003780 ABC transporter signature motif; other site 755731003781 Walker B; other site 755731003782 D-loop; other site 755731003783 H-loop/switch region; other site 755731003784 galactose mutarotase_like; Region: galactose_mutarotase_like; cd09019 755731003785 active site 755731003786 catalytic residues [active] 755731003787 Probable zinc-binding domain; Region: zf-trcl; pfam13451 755731003788 MutS domain III; Region: MutS_III; pfam05192 755731003789 DNA-binding domain of DNA mismatch repair MUTS family; Region: MUTSd; smart00533 755731003790 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 755731003791 Walker A/P-loop; other site 755731003792 ATP binding site [chemical binding]; other site 755731003793 Q-loop/lid; other site 755731003794 ABC transporter signature motif; other site 755731003795 Walker B; other site 755731003796 D-loop; other site 755731003797 H-loop/switch region; other site 755731003798 peptide chain release factor 3; Provisional; Region: prfC; PRK00741 755731003799 Release Factor 3 (RF3) protein involved in the terminal step of translocation in bacteria; Region: RF3; cd04169 755731003800 G1 box; other site 755731003801 putative GEF interaction site [polypeptide binding]; other site 755731003802 GTP/Mg2+ binding site [chemical binding]; other site 755731003803 Switch I region; other site 755731003804 G2 box; other site 755731003805 G3 box; other site 755731003806 Switch II region; other site 755731003807 G4 box; other site 755731003808 G5 box; other site 755731003809 RF3_II: this subfamily represents the domain II of bacterial Release Factor 3 (RF3). Termination of protein synthesis by the ribosome requires two release factor (RF) classes. The class II RF3 is a GTPase that removes class I RFs (RF1 or RF2) from the...; Region: RF3_II; cd03689 755731003810 The TGS domain, named after the ThrRS, GTPase, and SpoT/RelA proteins where it occurs, is structurally similar to ubiquitin. TGS is a small domain of about 50 amino acid residues with a predominantly beta-sheet structure. There is no direct information...; Region: TGS; cl15768 755731003811 Uridine kinase [Nucleotide transport and metabolism]; Region: Udk; COG0572 755731003812 Uridine monophosphate kinase_like (UMPK_like) is a family of proteins highly similar to the uridine monophosphate kinase (UMPK, EC 2.7.1.48), also known as uridine kinase or uridine-cytidine kinase (UCK); Region: UMPK_like; cd02028 755731003813 active site 755731003814 DRTGG domain; Region: DRTGG; pfam07085 755731003815 rRNA methylases [Translation, ribosomal structure and biogenesis]; Region: SpoU; COG0566 755731003816 RNA 2'-O ribose methyltransferase substrate binding; Region: SpoU_sub_bind; smart00967 755731003817 SpoU rRNA Methylase family; Region: SpoU_methylase; pfam00588 755731003818 Transcriptional regulators [Transcription]; Region: PurR; COG1609 755731003819 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 755731003820 DNA binding site [nucleotide binding] 755731003821 domain linker motif; other site 755731003822 Ligand binding domain of the LacI tanscriptional regulator family belonging to the type I periplasmic-binding fold protein superfamily; Region: PBP1_LacI_sugar_binding_like; cd06267 755731003823 dimerization interface [polypeptide binding]; other site 755731003824 ligand binding site [chemical binding]; other site 755731003825 N-terminal domain of glycoside hydrolase family 94 and related domains; Region: GH94N_like; cl17067 755731003826 Protein of unknown function, DUF608; Region: DUF608; pfam04685 755731003827 Protein of unknown function (DUF1407); Region: DUF1407; pfam07191 755731003828 chromosome segregation protein SMC, common bacterial type; Region: SMC_prok_B; TIGR02168 755731003829 phenylalanyl-tRNA synthetase subunit alpha; Validated; Region: pheS; PRK00488 755731003830 Aminoacyl tRNA synthetase class II, N-terminal domain; Region: Phe_tRNA-synt_N; pfam02912 755731003831 Phenylalanyl-tRNA synthetase (PheRS) alpha chain catalytic core domain. PheRS belongs to class II aminoacyl-tRNA synthetases (aaRS) based upon its structure and the presence of three characteristic sequence motifs. This domain is primarily responsible...; Region: PheRS_alpha_core; cd00496 755731003832 dimer interface [polypeptide binding]; other site 755731003833 motif 1; other site 755731003834 active site 755731003835 motif 2; other site 755731003836 motif 3; other site 755731003837 phenylalanyl-tRNA synthetase subunit beta; Reviewed; Region: pheT; PRK00629 755731003838 tRNA-binding-domain-containing prokaryotic phenylalanly tRNA synthetase (PheRS) beta chain. PheRS aminoacylate phenylalanine transfer RNAs (tRNAphe). PheRSs belong structurally to class II aminoacyl tRNA synthetases (aaRSs) but, as they aminoacylate...; Region: tRNA_bind_bactPheRS; cd02796 755731003839 putative tRNA-binding site [nucleotide binding]; other site 755731003840 B3/4 domain; Region: B3_4; pfam03483 755731003841 tRNA synthetase B5 domain; Region: B5; smart00874 755731003842 Class II tRNA amino-acyl synthetase-like catalytic core domain. Class II amino acyl-tRNA synthetases (aaRS) share a common fold and generally attach an amino acid to the 3' OH of ribose of the appropriate tRNA. PheRS is an exception in that it...; Region: class_II_aaRS-like_core; cl00268 755731003843 motif 1; other site 755731003844 dimer interface [polypeptide binding]; other site 755731003845 active site 755731003846 motif 2; other site 755731003847 motif 3; other site 755731003848 Ferredoxin-fold anticodon binding domain; Region: FDX-ACB; pfam03147 755731003849 Small, acid-soluble spore proteins, alpha/beta type; Region: SASP; pfam00269 755731003850 glucose-6-phosphate isomerase; Provisional; Region: pgi; PRK14097 755731003851 Phosphoglucose isomerase (PGI) contains two SIS (Sugar ISomerase) domains. This classification is based on the alignment of the first SIS domain. PGI is a multifunctional enzyme which as an intracellular dimer catalyzes the reversible isomerization of...; Region: SIS_PGI_1; cd05015 755731003852 active site 755731003853 dimer interface [polypeptide binding]; other site 755731003854 Phosphoglucose isomerase (PGI) contains two SIS (Sugar ISomerase) domains. This classification is based on the alignment of the second SIS domain. PGI is a multifunctional enzyme which as an intracellular dimer catalyzes the reversible isomerization of...; Region: SIS_PGI_2; cd05016 755731003855 dimer interface [polypeptide binding]; other site 755731003856 active site 755731003857 Folylpolyglutamate synthase [Coenzyme metabolism]; Region: FolC; COG0285 755731003858 Mur ligase middle domain; Region: Mur_ligase_M; pfam08245 755731003859 Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875 755731003860 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 755731003861 TPR motif; other site 755731003862 tol-pal system protein YbgF; Region: tol_pal_ybgF; TIGR02795 755731003863 Tetratricopeptide repeat; Region: TPR_6; pfam13174 755731003864 ExoU and VipD-like proteins; homologus to patatin, cPLA2, and iPLA2; Region: Pat_ExoU_VipD_like; cd07207 755731003865 Threonine synthase [Amino acid transport and metabolism]; Region: ThrC; COG0498 755731003866 Threonine synthase catalyzes the final step of threonine biosynthesis. The conversion of O-phosphohomoserine into threonine and inorganic phosphate is pyridoxal 5'-phosphate dependent. The Thr-synth_1 CD includes members from higher plants; Region: Thr-synth_2; cd01560 755731003867 pyridoxal 5'-phosphate binding site [chemical binding]; other site 755731003868 catalytic residue [active] 755731003869 hypothetical protein; Provisional; Region: PRK04435 755731003870 ACT domains are commonly involved in specifically binding an amino acid or other small ligand leading to regulation of the enzyme; Region: ACT; cl09141 755731003871 homoserine dehydrogenase; Provisional; Region: PRK06349 755731003872 Homoserine dehydrogenase, NAD binding domain; Region: NAD_binding_3; pfam03447 755731003873 Homoserine dehydrogenase; Region: Homoserine_dh; pfam00742 755731003874 ECF-type riboflavin transporter, S component; Region: ECF-ribofla_trS; pfam07155 755731003875 Trp repressor protein; Region: Trp_repressor; cl17266 755731003876 preprotein translocase subunit SecA; Reviewed; Region: PRK12904 755731003877 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cl17251 755731003878 SecA preprotein cross-linking domain; Region: SecA_PP_bind; smart00958 755731003879 SEC-C motif; Region: SEC-C; pfam02810 755731003880 DNA polymerase III DnaE; Reviewed; Region: dnaE; PRK06826 755731003881 Polymerase and Histidinol Phosphatase domain of alpha-subunit of bacterial polymerase III DnaE3; Region: PHP_PolIIIA_DnaE3; cd12113 755731003882 active site 755731003883 PHP Thumb interface [polypeptide binding]; other site 755731003884 metal binding site [ion binding]; metal-binding site 755731003885 DnaE_OBF: A subfamily of OB folds corresponding to the C-terminal OB-fold nucleic acid binding domain of Thermus aquaticus and Escherichia coli type C replicative DNA polymerase III alpha subunit (DnaE). The DNA polymerase holoenzyme of E. coli contains...; Region: DnaE_OBF; cd04485 755731003886 generic binding surface II; other site 755731003887 generic binding surface I; other site 755731003888 transcription attenuation protein MtrB; Provisional; Region: PRK13251 755731003889 4-hydroxybenzoyl-CoA thioesterase (4HBT). Catalyzes the final step in the 4-chlorobenzoate degradation pathway in which 4-chlorobenzoate is converted to 4-hydroxybenzoate in certain soil-dwelling bacteria. 4HBT forms a homotetramer with four active sites; Region: 4HBT; cd00586 755731003890 active site 755731003891 Phosphatidylglycerophosphate synthase [Lipid metabolism]; Region: PgsA; COG0558 755731003892 DnaJ domain or J-domain. DnaJ/Hsp40 (heat shock protein 40) proteins are highly conserved and play crucial roles in protein translation, folding, unfolding, translocation, and degradation. They act primarily by stimulating the ATPase activity of Hsp70s; Region: DnaJ; cd06257 755731003893 DnaJ-class molecular chaperone with C-terminal Zn finger domain [Posttranslational modification, protein turnover, chaperones]; Region: DnaJ; COG0484 755731003894 HSP70 interaction site [polypeptide binding]; other site 755731003895 Tetratricopeptide repeat; Region: TPR_16; pfam13432 755731003896 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 755731003897 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 755731003898 non-specific DNA binding site [nucleotide binding]; other site 755731003899 salt bridge; other site 755731003900 sequence-specific DNA binding site [nucleotide binding]; other site 755731003901 Cupin domain; Region: Cupin_2; pfam07883 755731003902 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 755731003903 Acyl-coenzyme A synthetases/AMP-(fatty) acid ligases [Lipid metabolism]; Region: Acs; COG0365 755731003904 acyl-activating enzyme (AAE) consensus motif; other site 755731003905 AMP binding site [chemical binding]; other site 755731003906 active site 755731003907 CoA binding site [chemical binding]; other site 755731003908 recombination and DNA strand exchange inhibitor protein; Reviewed; Region: PRK00409 755731003909 MutS domain III; Region: MutS_III; pfam05192 755731003910 ATP-binding cassette domain of MutS2; Region: ABC_MutS2; cd03280 755731003911 Walker A/P-loop; other site 755731003912 ATP binding site [chemical binding]; other site 755731003913 Q-loop/lid; other site 755731003914 ABC transporter signature motif; other site 755731003915 Walker B; other site 755731003916 D-loop; other site 755731003917 H-loop/switch region; other site 755731003918 ATP synthase B/B' CF(0); Region: ATP-synt_B; cl17192 755731003919 Smr domain; Region: Smr; pfam01713 755731003920 Predicted membrane GTPase involved in stress response [Signal transduction mechanisms]; Region: TypA; COG1217 755731003921 Tyrosine phosphorylated protein A (TypA)/BipA family belongs to ribosome-binding GTPases; Region: TypA_BipA; cd01891 755731003922 G1 box; other site 755731003923 putative GEF interaction site [polypeptide binding]; other site 755731003924 GTP/Mg2+ binding site [chemical binding]; other site 755731003925 Switch I region; other site 755731003926 G2 box; other site 755731003927 G3 box; other site 755731003928 Switch II region; other site 755731003929 G4 box; other site 755731003930 G5 box; other site 755731003931 BipA_TypA_II: domain II of BipA (also called TypA) having homology to domain II of the elongation factors (EFs) EF-G and EF-Tu. BipA is a highly conserved protein with global regulatory properties in Escherichia coli. BipA is phosphorylated on a...; Region: BipA_TypA_II; cd03691 755731003932 BipA_TypA_C: a C-terminal portion of BipA or TypA having homology to the C terminal domains of the elongation factors EF-G and EF-2. A member of the ribosome binding GTPase superfamily, BipA is widely distributed in bacteria and plants. BipA is a highly...; Region: BipA_TypA_C; cd03710 755731003933 YceG-like family; Region: YceG; pfam02618 755731003934 proteins similar to Escherichia coli yceG; Region: yceG_like; cd08010 755731003935 dimerization interface [polypeptide binding]; other site 755731003936 Predicted O-methyltransferase [General function prediction only]; Region: COG4122 755731003937 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 755731003938 S-adenosylmethionine binding site [chemical binding]; other site 755731003939 Collagenase and related proteases [Posttranslational modification, protein turnover, chaperones]; Region: COG0826 755731003940 Peptidase family U32; Region: Peptidase_U32; pfam01136 755731003941 CRISPR/Cas system-associated protein Cas3'' Region: Cas3''_I; cd09641 755731003942 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cl17251 755731003943 CRISPR-associated helicase Cas3; Region: cas3_core; TIGR01587 755731003944 CRISPR-associated protein (Cas_Cas5); Region: Cas_Cas5d; pfam09704 755731003945 CRISPR/Cas system-associated RAMP superfamily protein Cas5; Region: Cas5_I-C; cd09651 755731003946 CRISPR/Cas system-associated protein Cas8c; Region: Cas8c_I-C; cd09757 755731003947 CRISPR/Cas system-associated RAMP superfamily protein Cas7; Region: Cas7_I-C; cl01465 755731003948 Domain of unknown function DUF83; Region: Cas_Cas4; pfam01930 755731003949 CRISPR/Cas system-associated protein Cas1; Region: Cas1_I-C; cd09721 755731003950 CRISPR/Cas system-associated protein Cas2; Region: Cas2_I_II_III; cd09725 755731003951 Acetyltransferases [General function prediction only]; Region: RimI; COG0456 755731003952 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 755731003953 Coenzyme A binding pocket [chemical binding]; other site 755731003954 penicillin-binding protein 2; Region: pbp2_mrdA; TIGR03423 755731003955 Penicillin-binding Protein dimerisation domain; Region: PBP_dimer; pfam03717 755731003956 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; pfam00905 755731003957 Glycosyl hydrolase family 81; Region: Glyco_hydro_81; cl02310 755731003958 RNA polymerase sigma factor, sigma-70 family; Region: sigma70-ECF; TIGR02937 755731003959 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cl17257 755731003960 DNA binding residues [nucleotide binding] 755731003961 HYR domain; Region: HYR; pfam02494 755731003962 HYR domain; Region: HYR; pfam02494 755731003963 HYR domain; Region: HYR; pfam02494 755731003964 HYR domain; Region: HYR; pfam02494 755731003965 HYR domain; Region: HYR; pfam02494 755731003966 HYR domain; Region: HYR; pfam02494 755731003967 HYR domain; Region: HYR; pfam02494 755731003968 Cellulose binding domain; Region: CBM_3; pfam00942 755731003969 MAEBL; Provisional; Region: PTZ00121 755731003970 coenzyme F420 hydrogenase, subunit alpha; Region: frhA; TIGR03295 755731003971 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 755731003972 ATPases associated with a variety of cellular activities; Region: AAA; smart00382 755731003973 Walker A motif; other site 755731003974 ATP binding site [chemical binding]; other site 755731003975 Walker B motif; other site 755731003976 arginine finger; other site 755731003977 Protein of unknown function (DUF4255); Region: DUF4255; pfam14065 755731003978 tail sheath protein; Provisional; Region: 18; PHA02539 755731003979 Phage tail sheath protein FI [General function prediction only]; Region: COG3497 755731003980 T4-like virus tail tube protein gp19; Region: Phage_T4_gp19; pfam06841 755731003981 T4-like virus tail tube protein gp19; Region: Phage_T4_gp19; pfam06841 755731003982 Uncharacterized protein containing LysM domain [Function unknown]; Region: XkdP; COG1652 755731003983 Phage protein D [General function prediction only]; Region: COG3500 755731003984 Phage-related baseplate assembly protein; Region: Phage_base_V; pfam04717 755731003985 PAAR motif; Region: PAAR_motif; cl15808 755731003986 Gene 25-like lysozyme; Region: GPW_gp25; pfam04965 755731003987 conserved hypothetical protein, phage tail-like region; Region: TIGR02243 755731003988 conserved hypothetical protein, phage tail-like region; Region: TIGR02243 755731003989 conserved hypothetical protein, phage tail-like region; Region: TIGR02243 755731003990 conserved hypothetical protein, phage tail-like region; Region: TIGR02243 755731003991 phage tail protein domain; Region: tail_TIGR02242 755731003992 Chaperone of endosialidase; Region: Peptidase_S74; pfam13884 755731003993 Chaperone of endosialidase; Region: Peptidase_S74; pfam13884 755731003994 Chaperone of endosialidase; Region: Peptidase_S74; pfam13884 755731003995 Uncharacterized conserved protein [Function unknown]; Region: COG2966 755731003996 Protein of unknown function (DUF1212); Region: DUF1212; pfam06738 755731003997 Protein of unknown function (DUF3815); Region: DUF3815; pfam12821 755731003998 Uncharacterized protein conserved in bacteria [Function unknown]; Region: ErfK; COG1376 755731003999 L,D-transpeptidase catalytic domain; Region: YkuD; pfam03734 755731004000 The adenylation domain of nonribosomal peptide synthetases (NRPS) similar to mycosubtilin synthase subunit A (MycA); Region: A_NRPS_MycA_like; cd05908 755731004001 acyl-CoA synthetase; Validated; Region: PRK09192 755731004002 acyl-activating enzyme (AAE) consensus motif; other site 755731004003 putative AMP binding site [chemical binding]; other site 755731004004 Phosphopantetheine attachment site; Region: PP-binding; pfam00550 755731004005 Condensation domain; Region: Condensation; pfam00668 755731004006 Non-ribosomal peptide synthetase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: EntF; COG1020 755731004007 HxxPF-repeated domain; Region: HxxPF_rpt; pfam13745 755731004008 The adenylation domain of nonribosomal peptide synthetases (NRPS); Region: A_NRPS; cd05930 755731004009 acyl-activating enzyme (AAE) consensus motif; other site 755731004010 AMP binding site [chemical binding]; other site 755731004011 Phosphopantetheine attachment site; Region: PP-binding; pfam00550 755731004012 Condensation domain; Region: Condensation; pfam00668 755731004013 Non-ribosomal peptide synthetase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: EntF; COG1020 755731004014 non-ribosomal peptide synthase domain TIGR01720; Region: NRPS-para261 755731004015 Condensation domain; Region: Condensation; pfam00668 755731004016 Non-ribosomal peptide synthetase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: EntF; COG1020 755731004017 The adenylation domain of nonribosomal peptide synthetases (NRPS), including Bacillus subtilis termination module Surfactin (SrfA-C); Region: A_NRPS_Srf_like; cd12117 755731004018 acyl-activating enzyme (AAE) consensus motif; other site 755731004019 AMP binding site [chemical binding]; other site 755731004020 Phosphopantetheine attachment site; Region: PP-binding; pfam00550 755731004021 Condensation domain; Region: Condensation; pfam00668 755731004022 Non-ribosomal peptide synthetase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: EntF; COG1020 755731004023 HxxPF-repeated domain; Region: HxxPF_rpt; pfam13745 755731004024 The adenylation domain of nonribosomal peptide synthetases (NRPS); Region: A_NRPS; cd05930 755731004025 acyl-activating enzyme (AAE) consensus motif; other site 755731004026 AMP binding site [chemical binding]; other site 755731004027 Phosphopantetheine attachment site; Region: PP-binding; pfam00550 755731004028 Condensation domain; Region: Condensation; pfam00668 755731004029 Non-ribosomal peptide synthetase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: EntF; COG1020 755731004030 HxxPF-repeated domain; Region: HxxPF_rpt; pfam13745 755731004031 The adenylation domain of nonribosomal peptide synthetases (NRPS); Region: A_NRPS; cd05930 755731004032 acyl-activating enzyme (AAE) consensus motif; other site 755731004033 AMP binding site [chemical binding]; other site 755731004034 Phosphopantetheine attachment site; Region: PP-binding; pfam00550 755731004035 CAAX protease self-immunity; Region: Abi; pfam02517 755731004036 CAAX protease self-immunity; Region: Abi; pfam02517 755731004037 polyketide synthases (PKSs) polymerize simple fatty acids into a large variety of different products, called polyketides, by successive decarboxylating Claisen condensations. PKSs can be divided into 2 groups, modular type I PKSs consisting of one or...; Region: PKS; cd00833 755731004038 Beta-ketoacyl synthase; Region: PKS_KS; smart00825 755731004039 active site 755731004040 Phosphopantetheine attachment site; Region: PP-binding; pfam00550 755731004041 Condensation domain; Region: Condensation; pfam00668 755731004042 Non-ribosomal peptide synthetase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: EntF; COG1020 755731004043 HxxPF-repeated domain; Region: HxxPF_rpt; pfam13745 755731004044 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 755731004045 Methyltransferase domain; Region: Methyltransf_31; pfam13847 755731004046 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 755731004047 S-adenosylmethionine binding site [chemical binding]; other site 755731004048 The adenylation domain of nonribosomal peptide synthetases (NRPS); Region: A_NRPS; cd05930 755731004049 amino acid adenylation domain; Region: AA-adenyl-dom; TIGR01733 755731004050 acyl-activating enzyme (AAE) consensus motif; other site 755731004051 AMP binding site [chemical binding]; other site 755731004052 Phosphopantetheine attachment site; Region: PP-binding; pfam00550 755731004053 Condensation domain; Region: Condensation; pfam00668 755731004054 Non-ribosomal peptide synthetase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: EntF; COG1020 755731004055 HxxPF-repeated domain; Region: HxxPF_rpt; pfam13745 755731004056 The adenylation domain of nonribosomal peptide synthetases (NRPS); Region: A_NRPS; cd05930 755731004057 acyl-activating enzyme (AAE) consensus motif; other site 755731004058 AMP binding site [chemical binding]; other site 755731004059 Phosphopantetheine attachment site; Region: PP-binding; pfam00550 755731004060 Condensation domain; Region: Condensation; pfam00668 755731004061 Non-ribosomal peptide synthetase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: EntF; COG1020 755731004062 HxxPF-repeated domain; Region: HxxPF_rpt; pfam13745 755731004063 Non-ribosomal peptide synthetase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: EntF; COG1020 755731004064 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 755731004065 Methyltransferase domain; Region: Methyltransf_31; pfam13847 755731004066 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 755731004067 S-adenosylmethionine binding site [chemical binding]; other site 755731004068 The adenylation domain of nonribosomal peptide synthetases (NRPS), including Streptoalloteichus tallysomycin biosynthesis genes; Region: A_NRPS_TlmIV_like; cd12114 755731004069 acyl-activating enzyme (AAE) consensus motif; other site 755731004070 AMP binding site [chemical binding]; other site 755731004071 Condensation domain; Region: Condensation; pfam00668 755731004072 non-ribosomal peptide synthase domain TIGR01720; Region: NRPS-para261 755731004073 A predicted NlpC/p60-like peptidase; Region: BtrH; pfam14399 755731004074 2-phosphoglycerate kinase; Provisional; Region: PRK12339 755731004075 AAA domain; Region: AAA_17; pfam13207 755731004076 Bacterial transcription activator, effector binding domain; Region: AraC_E_bind; smart00871 755731004077 Alpha/beta hydrolase family; Region: Abhydrolase_5; pfam12695 755731004078 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 755731004079 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 755731004080 Beta-mannanase [Carbohydrate transport and metabolism]; Region: ManB; COG4124 755731004081 Dockerin type I repeat; Region: Dockerin_1; pfam00404 755731004082 ABC-2 type transporter; Region: ABC2_membrane; cl17235 755731004083 ABC-type multidrug transport system, permease component [Defense mechanisms]; Region: COG0842 755731004084 ABC transporter, ATP-binding subunit, PQQ-dependent alcohol dehydrogenase system; Region: PQQ_ABC_ATP; TIGR03864 755731004085 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 755731004086 Walker A/P-loop; other site 755731004087 ATP binding site [chemical binding]; other site 755731004088 Q-loop/lid; other site 755731004089 ABC transporter signature motif; other site 755731004090 Walker B; other site 755731004091 D-loop; other site 755731004092 H-loop/switch region; other site 755731004093 Protein of unknown function (DUF1048); Region: DUF1048; pfam06304 755731004094 Protein of unknown function (DUF1048); Region: DUF1048; pfam06304 755731004095 Predicted transcriptional regulators [Transcription]; Region: COG1695 755731004096 Transcriptional regulator PadR-like family; Region: PadR; pfam03551 755731004097 Domain of unknown function (DUF4157); Region: DUF4157; pfam13699 755731004098 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 755731004099 S-adenosylmethionine binding site [chemical binding]; other site 755731004100 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 755731004101 This domain superfamily is found in a variety of structurally related metalloproteins, including the type I extradiol dioxygenases, glyoxalase I and a group of antibiotic resistance proteins; Region: Glo_EDI_BRP_like; cd06587 755731004102 active site 755731004103 metal binding site [ion binding]; metal-binding site 755731004104 Rhamnogalacturonan lyase of the polysaccharide lyase family 11; Region: RGL11; cd10318 755731004105 metal binding site [ion binding]; metal-binding site 755731004106 active site 755731004107 Uncharacterized protein family (UPF0160); Region: UPF0160; pfam03690 755731004108 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 755731004109 S-adenosylmethionine binding site [chemical binding]; other site 755731004110 Cysteine-rich CPCC; Region: Cys_rich_CPCC; pfam14206 755731004111 Helix-turn-helix domain; Region: HTH_18; pfam12833 755731004112 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 755731004113 GyrI-like small molecule binding domain; Region: GyrI-like; cl01368 755731004114 Protein of unknown function (DUF3888); Region: DUF3888; pfam13027 755731004115 Domain of unknown function (DUF4177); Region: DUF4177; pfam13783 755731004116 NADPH-dependent FMN reductase; Region: FMN_red; pfam03358 755731004117 Multimeric flavodoxin WrbA [General function prediction only]; Region: WrbA; COG0655 755731004118 Site-specific recombinases, DNA invertase Pin homologs [DNA replication, recombination, and repair]; Region: PinR; COG1961 755731004119 Serine Recombinase family, catalytic domain; a DNA binding domain may be present either N- or C-terminal to the catalytic domain. These enzymes perform site-specific recombination of DNA molecules by a concerted, four-strand cleavage and rejoining...; Region: Ser_Recombinase; cd00338 755731004120 catalytic residues [active] 755731004121 catalytic nucleophile [active] 755731004122 Recombinase; Region: Recombinase; pfam07508 755731004123 Recombinase zinc beta ribbon domain; Region: Zn_ribbon_recom; pfam13408 755731004124 Cellulase (glycosyl hydrolase family 5); Region: Cellulase; pfam00150 755731004125 Carbohydrate binding domain (family 17/28); Region: CBM_17_28; pfam03424 755731004126 Carbohydrate binding domain (family 17/28); Region: CBM_17_28; pfam03424 755731004127 S-layer homology domain; Region: SLH; pfam00395 755731004128 Methyltransferase domain; Region: Methyltransf_26; pfam13659 755731004129 Adenine-specific DNA methylase [DNA replication, recombination, and repair]; Region: COG0827 755731004130 DNA methylase [Transcription / DNA replication, recombination, and repair]; Region: COG4646 755731004131 DEAD-like helicases superfamily; Region: DEXDc; smart00487 755731004132 DNA methylase [Transcription / DNA replication, recombination, and repair]; Region: COG4646 755731004133 helicase superfamily c-terminal domain; Region: HELICc; smart00490 755731004134 nucleotide binding region [chemical binding]; other site 755731004135 ATP-binding site [chemical binding]; other site 755731004136 ATPases involved in chromosome partitioning [Cell division and chromosome partitioning]; Region: Soj; COG1192 755731004137 ParA and ParB of Caulobacter crescentus belong to a conserved family of bacterial proteins implicated in chromosome segregation. ParB binds to DNA sequences adjacent to the origin of replication and localizes to opposite cell poles shortly following the...; Region: ParA; cd02042 755731004138 P-loop; other site 755731004139 Magnesium ion binding site [ion binding]; other site 755731004140 ParA and ParB of Caulobacter crescentus belong to a conserved family of bacterial proteins implicated in chromosome segregation. ParB binds to DNA sequences adjacent to the origin of replication and localizes to opposite cell poles shortly following the...; Region: ParA; cd02042 755731004141 Magnesium ion binding site [ion binding]; other site 755731004142 ParB-like nuclease domain; Region: ParBc; pfam02195 755731004143 ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other...; Region: ANK; cd00204 755731004144 Ankyrin repeats (3 copies); Region: Ank_2; pfam12796 755731004145 CHC2 zinc finger; Region: zf-CHC2; cl17510 755731004146 Protein of unknown function (DUF3991); Region: DUF3991; pfam13154 755731004147 Toprim-like; Region: Toprim_2; pfam13155 755731004148 Methyltransferase domain; Region: Methyltransf_26; pfam13659 755731004149 Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase; Region: HATPase_c_3; pfam13589 755731004150 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 755731004151 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 755731004152 ATP binding site [chemical binding]; other site 755731004153 Mg2+ binding site [ion binding]; other site 755731004154 G-X-G motif; other site 755731004155 HNH nucleases; HNH endonuclease signature which is found in viral, prokaryotic, and eukaryotic proteins. The alignment includes members of the large group of homing endonucleases, yeast intron 1 protein, MutS, as well as bacterial colicins, pyocins, and...; Region: HNHc; cd00085 755731004156 active site 755731004157 RecA-like NTPases. This family includes the NTP binding domain of F1 and V1 H+ATPases, DnaB and related helicases as well as bacterial RecA and related eukaryotic and archaeal recombinases. This group also includes bacterial conjugation proteins and...; Region: RecA-like_NTPases; cl17233 755731004158 Walker A motif; other site 755731004159 ATP binding site [chemical binding]; other site 755731004160 Walker B motif; other site 755731004161 FRG domain; Region: FRG; pfam08867 755731004162 Domains similar to fish antifreeze type III protein; Region: SAF; cl00555 755731004163 AAA domain; Region: AAA_31; pfam13614 755731004164 Type IV secretory pathway, VirB11 components, and related ATPases involved in archaeal flagella biosynthesis [Cell motility and secretion / Intracellular trafficking and secretion]; Region: VirB11; COG0630 755731004165 RecA-like NTPases. This family includes the NTP binding domain of F1 and V1 H+ATPases, DnaB and related helicases as well as bacterial RecA and related eukaryotic and archaeal recombinases. This group also includes bacterial conjugation proteins and...; Region: RecA-like_NTPases; cl17233 755731004166 Walker A motif; other site 755731004167 ATP binding site [chemical binding]; other site 755731004168 Walker B motif; other site 755731004169 S-layer homology domain; Region: SLH; pfam00395 755731004170 S-layer homology domain; Region: SLH; pfam00395 755731004171 Regulators of stationary/sporulation gene expression [Transcription]; Region: AbrB; COG2002 755731004172 SpoVT / AbrB like domain; Region: SpoVT_AbrB; smart00966 755731004173 MafB19-like deaminase; Region: MafB19-deam; pfam14437 755731004174 hypothetical protein; Region: PHA00662 755731004175 AAA-like domain; Region: AAA_10; pfam12846 755731004176 Membrane proteins related to metalloendopeptidases [Cell envelope biogenesis, outer membrane]; Region: NlpD; COG0739 755731004177 Peptidase family M23; Region: Peptidase_M23; pfam01551 755731004178 Helix-turn-helix domain; Region: HTH_36; pfam13730 755731004179 Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all...; Region: FN3; cd00063 755731004180 Interdomain contacts; other site 755731004181 Cytokine receptor motif; other site 755731004182 Regulator of chromosome condensation (RCC1) repeat; Region: RCC1_2; pfam13540 755731004183 Regulator of chromosome condensation (RCC1) repeat; Region: RCC1; pfam00415 755731004184 Regulator of chromosome condensation (RCC1) repeat; Region: RCC1; pfam00415 755731004185 Regulator of chromosome condensation (RCC1) repeat; Region: RCC1; pfam00415 755731004186 Regulator of chromosome condensation (RCC1) repeat; Region: RCC1; pfam00415 755731004187 Regulator of chromosome condensation (RCC1) repeat; Region: RCC1; pfam00415 755731004188 Regulator of chromosome condensation (RCC1) repeat; Region: RCC1; pfam00415 755731004189 Regulator of chromosome condensation (RCC1) repeat; Region: RCC1; pfam00415 755731004190 Regulator of chromosome condensation (RCC1) repeat; Region: RCC1_2; pfam13540 755731004191 Regulator of chromosome condensation (RCC1) repeat; Region: RCC1; pfam00415 755731004192 Regulator of chromosome condensation (RCC1) repeat; Region: RCC1; pfam00415 755731004193 Regulator of chromosome condensation (RCC1) repeat; Region: RCC1_2; pfam13540 755731004194 Regulator of chromosome condensation (RCC1) repeat; Region: RCC1; pfam00415 755731004195 Regulator of chromosome condensation (RCC1) repeat; Region: RCC1; pfam00415 755731004196 Regulator of chromosome condensation (RCC1) repeat; Region: RCC1_2; pfam13540 755731004197 Rhs family protein [Cell envelope biogenesis, outer membrane]; Region: RhsA; COG3209 755731004198 RHS repeat-associated core domain; Region: Rhs_assc_core; TIGR03696 755731004199 Domain of unknown function (DUF4258); Region: DUF4258; pfam14076 755731004200 Cytochrome c oxidase assembly protein CtaG/Cox11; Region: CtaG_Cox11; cl01240 755731004201 metallophosphatase superfamily, metallophosphatase domain; Region: MPP_superfamily; cl13995 755731004202 Calcineurin-like phosphoesterase; Region: Metallophos; pfam00149 755731004203 active site 755731004204 metal binding site [ion binding]; metal-binding site 755731004205 Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase; Region: HATPase_c; pfam02518 755731004206 FOG: CheY-like receiver [Signal transduction mechanisms]; Region: CheY; COG0784 755731004207 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 755731004208 active site 755731004209 phosphorylation site [posttranslational modification] 755731004210 intermolecular recognition site; other site 755731004211 dimerization interface [polypeptide binding]; other site 755731004212 LytTr DNA-binding domain; Region: LytTR; pfam04397 755731004213 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 755731004214 non-specific DNA binding site [nucleotide binding]; other site 755731004215 salt bridge; other site 755731004216 sequence-specific DNA binding site [nucleotide binding]; other site 755731004217 Site-specific recombinases, DNA invertase Pin homologs [DNA replication, recombination, and repair]; Region: PinR; COG1961 755731004218 Serine Recombinase family, catalytic domain; a DNA binding domain may be present either N- or C-terminal to the catalytic domain. These enzymes perform site-specific recombination of DNA molecules by a concerted, four-strand cleavage and rejoining...; Region: Ser_Recombinase; cd00338 755731004219 catalytic residues [active] 755731004220 catalytic nucleophile [active] 755731004221 Recombinase; Region: Recombinase; pfam07508 755731004222 Recombinase zinc beta ribbon domain; Region: Zn_ribbon_recom; pfam13408 755731004223 Glycoside hydrolase family 44; Region: Glyco_hydro_44; pfam12891 755731004224 Alpha-L-arabinofuranosidase C-terminus; Region: Alpha-L-AF_C; cl01412 755731004225 Dockerin type I repeat; Region: Dockerin_1; pfam00404 755731004226 polycystic kidney disease I (PKD) domain; similar to other cell-surface modules, with an IG-like fold; domain probably functions as a ligand binding site in protein-protein or protein-carbohydrate interactions; a single instance of the repeat is...; Region: PKD; cd00146 755731004227 Site-specific recombinases, DNA invertase Pin homologs [DNA replication, recombination, and repair]; Region: PinR; COG1961 755731004228 Serine Recombinase family, catalytic domain; a DNA binding domain may be present either N- or C-terminal to the catalytic domain. These enzymes perform site-specific recombination of DNA molecules by a concerted, four-strand cleavage and rejoining...; Region: Ser_Recombinase; cd00338 755731004229 catalytic residues [active] 755731004230 catalytic nucleophile [active] 755731004231 Recombinase; Region: Recombinase; pfam07508 755731004232 Recombinase zinc beta ribbon domain; Region: Zn_ribbon_recom; pfam13408 755731004233 Ferritin-like superfamily of diiron-containing four-helix-bundle proteins; Region: Ferritin_like; cl00264 755731004234 CotJB protein; Region: CotJB; pfam12652 755731004235 Spore coat associated protein JA (CotJA); Region: CotJA; pfam11007 755731004236 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 755731004237 ABC-type nitrate/sulfonate/bicarbonate transport system, ATPase component [Inorganic ion transport and metabolism]; Region: TauB; COG1116 755731004238 ATP-binding cassette domain of the nitrate and sulfonate transporters; Region: ABC_NrtD_SsuB_transporters; cd03293 755731004239 Walker A/P-loop; other site 755731004240 ATP binding site [chemical binding]; other site 755731004241 Q-loop/lid; other site 755731004242 ABC transporter signature motif; other site 755731004243 Walker B; other site 755731004244 D-loop; other site 755731004245 H-loop/switch region; other site 755731004246 ABC-type nitrate/sulfonate/bicarbonate transport system, permease component [Inorganic ion transport and metabolism]; Region: TauC; COG0600 755731004247 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cl00427 755731004248 ABC-type nitrate/sulfonate/bicarbonate transport systems, periplasmic components [Inorganic ion transport and metabolism]; Region: TauA; COG0715 755731004249 NMT1-like family; Region: NMT1_2; pfam13379 755731004250 The HCP family of iron-sulfur proteins includes hybrid cluster protein (HCP), acetyl-CoA synthase (ACS), and carbon monoxide dehydrogenase (CODH), all of which contain [Fe4-S4] metal clusters at their active sites. These proteins have a conserved...; Region: HCP_like; cl14655 755731004251 Prismane/CO dehydrogenase family; Region: Prismane; pfam03063 755731004252 ACS interaction site; other site 755731004253 CODH interaction site; other site 755731004254 metal cluster binding site [ion binding]; other site 755731004255 Site-specific recombinases, DNA invertase Pin homologs [DNA replication, recombination, and repair]; Region: PinR; COG1961 755731004256 Serine Recombinase (SR) family, Resolvase and Invertase subfamily, catalytic domain; members contain a C-terminal DNA binding domain. Serine recombinases catalyze site-specific recombination of DNA molecules by a concerted, four-strand cleavage and...; Region: SR_ResInv; cd03768 755731004257 catalytic residues [active] 755731004258 catalytic nucleophile [active] 755731004259 Presynaptic Site I dimer interface [polypeptide binding]; other site 755731004260 Synaptic Antiparallel dimer interface [polypeptide binding]; other site 755731004261 Synaptic Flat tetramer interface [polypeptide binding]; other site 755731004262 Synaptic Site I dimer interface [polypeptide binding]; other site 755731004263 DNA binding site [nucleotide binding] 755731004264 Recombinase; Region: Recombinase; pfam07508 755731004265 Recombinase zinc beta ribbon domain; Region: Zn_ribbon_recom; pfam13408 755731004266 AraC-like ligand binding domain; Region: AraC_binding; pfam02311 755731004267 AraC-type DNA-binding domain-containing proteins [Transcription]; Region: AraC; COG2207 755731004268 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 755731004269 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 755731004270 Putative glycosyl hydrolase of unknown function (DUF1680); Region: DUF1680; pfam07944 755731004271 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3533 755731004272 Site-specific recombinases, DNA invertase Pin homologs [DNA replication, recombination, and repair]; Region: PinR; COG1961 755731004273 Serine Recombinase family, catalytic domain; a DNA binding domain may be present either N- or C-terminal to the catalytic domain. These enzymes perform site-specific recombination of DNA molecules by a concerted, four-strand cleavage and rejoining...; Region: Ser_Recombinase; cd00338 755731004274 catalytic residues [active] 755731004275 catalytic nucleophile [active] 755731004276 Recombinase; Region: Recombinase; pfam07508 755731004277 Recombinase zinc beta ribbon domain; Region: Zn_ribbon_recom; pfam13408 755731004278 Subfamily of the multidrug and toxic compound extrusion (MATE)-like proteins similar to Thermotoga marina NorM; Region: MATE_NorM_like; cd13137 755731004279 MATE family multidrug exporter; Provisional; Region: PRK10189 755731004280 Ribosomal protein S2 (RPS2), involved in formation of the translation initiation complex, where it might contact the messenger RNA and several components of the ribosome. It has been shown that in Escherichia coli RPS2 is essential for the binding of...; Region: RPS2; cd01425 755731004281 rRNA interaction site [nucleotide binding]; other site 755731004282 S8 interaction site; other site 755731004283 putative laminin-1 binding site; other site 755731004284 elongation factor Ts; Reviewed; Region: tsf; PRK12332 755731004285 UBA/TS-N domain; Region: UBA; pfam00627 755731004286 Elongation factor TS; Region: EF_TS; pfam00889 755731004287 UMP kinase (UMPK)-Ec, the microbial/chloroplast uridine monophosphate kinase (uridylate kinase) enzyme that catalyzes UMP phosphorylation and plays a key role in pyrimidine nucleotide biosynthesis; regulation of this process is via feed-back control and...; Region: AAK_UMPK-PyrH-Ec; cd04254 755731004288 putative nucleotide binding site [chemical binding]; other site 755731004289 uridine monophosphate binding site [chemical binding]; other site 755731004290 homohexameric interface [polypeptide binding]; other site 755731004291 ribosome recycling factor; Reviewed; Region: frr; PRK00083 755731004292 Ribosome recycling factor (RRF). Ribosome recycling factor dissociates the posttermination complex, composed of the ribosome, deacylated tRNA, and mRNA, after termination of translation. Thus ribosomes are "recycled" and ready for another...; Region: RRF; cd00520 755731004293 hinge region; other site 755731004294 Undecaprenyl pyrophosphate synthase [Lipid metabolism]; Region: UppS; COG0020 755731004295 Cis (Z)-Isoprenyl Diphosphate Synthases (cis-IPPS); homodimers which catalyze the successive 1'-4 condensation of the isopentenyl diphosphate (IPP) molecule to trans,trans-farnesyl diphosphate (FPP) or to cis,trans-FPP to form long-chain polyprenyl...; Region: CIS_IPPS; cd00475 755731004296 catalytic residue [active] 755731004297 putative FPP diphosphate binding site; other site 755731004298 putative FPP binding hydrophobic cleft; other site 755731004299 dimer interface [polypeptide binding]; other site 755731004300 putative IPP diphosphate binding site; other site 755731004301 CDP-diglyceride synthetase [Lipid metabolism]; Region: CdsA; COG0575 755731004302 Cytidylyltransferase family; Region: CTP_transf_1; pfam01148 755731004303 1-deoxy-D-xylulose 5-phosphate reductoisomerase; Provisional; Region: PRK05447 755731004304 1-deoxy-D-xylulose 5-phosphate reductoisomerase; Region: DXP_reductoisom; pfam02670 755731004305 1-deoxy-D-xylulose 5-phosphate reductoisomerase C-terminal; Region: DXP_redisom_C; pfam08436 755731004306 DXP reductoisomerase C-terminal domain; Region: DXPR_C; pfam13288 755731004307 RIP metalloprotease RseP; Region: TIGR00054 755731004308 RseP-like Site-2 proteases (S2P), zinc metalloproteases (MEROPS family M50A), cleave transmembrane domains of substrate proteins, regulating intramembrane proteolysis (RIP) of diverse signal transduction mechanisms. In Escherichia coli, the S2P homolog...; Region: S2P-M50_PDZ_RseP-like; cd06163 755731004309 active site 755731004310 PDZ domain of bacterial and plant zinc metalloprotases, presumably membrane-associated or integral membrane proteases, which may be involved in signalling and regulatory mechanisms. May be responsible for substrate recognition and/or binding, as most PDZ...; Region: PDZ_metalloprotease; cd00989 755731004311 PDZ domain of bacterial and plant zinc metalloprotases, presumably membrane-associated or integral membrane proteases, which may be involved in signalling and regulatory mechanisms. May be responsible for substrate recognition and/or binding, as most PDZ...; Region: PDZ_metalloprotease; cd00989 755731004312 RseP-like Site-2 proteases (S2P), zinc metalloproteases (MEROPS family M50A), cleave transmembrane domains of substrate proteins, regulating intramembrane proteolysis (RIP) of diverse signal transduction mechanisms. In Escherichia coli, the S2P homolog...; Region: S2P-M50_PDZ_RseP-like; cd06163 755731004313 putative substrate binding region [chemical binding]; other site 755731004314 4-hydroxy-3-methylbut-2-en-1-yl diphosphate synthase; Reviewed; Region: ispG; PRK00366 755731004315 4-hydroxy-3-methylbut-2-en-1-yl diphosphate synthase; Validated; Region: PRK00694 755731004316 4-hydroxy-3-methylbut-2-en-1-yl diphosphate synthase; Validated; Region: PRK00694 755731004317 DNA polymerase III PolC; Validated; Region: polC; PRK00448 755731004318 DNA polymerase III polC-type N-terminus; Region: DNA_pol3_alph_N; pfam11490 755731004319 polC_OBF: A subfamily of OB folds corresponding to the N-terminal OB-fold nucleic acid binding domain of Bacillus subtilis type C replicative DNA polymerase III alpha subunit (polC). Replication in B. subtilis and Staphylococcus aureus requires two...; Region: polC_OBF; cd04484 755731004320 generic binding surface II; other site 755731004321 generic binding surface I; other site 755731004322 Polymerase and Histidinol Phosphatase domain; Region: PHP; cl17102 755731004323 active site 755731004324 DEDDh 3'-5' exonuclease domain family; Region: DEDDh; cd06127 755731004325 active site 755731004326 catalytic site [active] 755731004327 substrate binding site [chemical binding]; other site 755731004328 Polymerase and Histidinol Phosphatase domain of alpha-subunit of bacterial polymerase III at PolC gene; Region: PHP_PolIIIA_POLC; cd07435 755731004329 active site 755731004330 ribosome maturation protein RimP; Reviewed; Region: PRK00092 755731004331 Sm and related proteins; Region: Sm_like; cl00259 755731004332 Bacillus subtilis YxlS-like, C-terminal domain; Region: YlxS_C; cd01734 755731004333 putative oligomer interface [polypeptide binding]; other site 755731004334 putative RNA binding site [nucleotide binding]; other site 755731004335 transcription termination factor NusA; Region: NusA; TIGR01953 755731004336 NusA N-terminal domain; Region: NusA_N; pfam08529 755731004337 S1_NusA: N-utilizing substance A protein (NusA), S1-like RNA-binding domain. S1-like RNA-binding domains are found in a wide variety of RNA-associated proteins. NusA is a transcription elongation factor containing an N-terminal catalytic domain and three...; Region: S1_NusA; cd04455 755731004338 RNA binding site [nucleotide binding]; other site 755731004339 homodimer interface [polypeptide binding]; other site 755731004340 NusA_K homology RNA-binding domain (KH). NusA is an essential multifunctional transcription elongation factor that is universally conserved among prokaryotes and archaea. NusA anti-termination function plays an important role in the expression of...; Region: NusA_KH; cd02134 755731004341 G-X-X-G motif; other site 755731004342 NusA_K homology RNA-binding domain (KH). NusA is an essential multifunctional transcription elongation factor that is universally conserved among prokaryotes and archaea. NusA anti-termination function plays an important role in the expression of...; Region: NusA_KH; cd02134 755731004343 G-X-X-G motif; other site 755731004344 Ylxr homologs; group of conserved hypothetical bacterial proteins of unknown function; structure revealed putative RNA binding cleft; proteins are encoded by an operon that includes other proteins involved in transcription and/or translation; Region: YlxR; cd00279 755731004345 putative RNA binding cleft [nucleotide binding]; other site 755731004346 Ribosomal protein L7Ae/L30e/S12e/Gadd45 family; Region: Ribosomal_L7Ae; cl00600 755731004347 Translation initiation factor IF-2, N-terminal region; Region: IF2_N; pfam04760 755731004348 Semenogelin; Region: Semenogelin; pfam05474 755731004349 translation initiation factor IF-2; Validated; Region: infB; PRK05306 755731004350 Translation initiation factor IF-2, N-terminal region; Region: IF2_N; pfam04760 755731004351 Initiation Factor 2 (IF2)/ eukaryotic Initiation Factor 5B (eIF5B) family; Region: IF2_eIF5B; cd01887 755731004352 G1 box; other site 755731004353 putative GEF interaction site [polypeptide binding]; other site 755731004354 GTP/Mg2+ binding site [chemical binding]; other site 755731004355 Switch I region; other site 755731004356 G2 box; other site 755731004357 G3 box; other site 755731004358 Switch II region; other site 755731004359 G4 box; other site 755731004360 G5 box; other site 755731004361 This family represents the domain II of bacterial Initiation Factor 2 (IF2) and its eukaryotic mitochondrial homologue mtIF2. IF2, the largest initiation factor is an essential GTP binding protein. In E. coli three natural forms of IF2 exist in the cell; Region: IF2_mtIF2_II; cd03702 755731004362 Translation-initiation factor 2; Region: IF-2; pfam11987 755731004363 mtIF2_IVc: this family represents the C2 subdomain of domain IV of mitochondrial translation initiation factor 2 (mtIF2) which adopts a beta-barrel fold displaying a high degree of structural similarity with domain II of the translation elongation factor...; Region: mtIF2_IVc; cd03692 755731004364 ribosome-binding factor A; Validated; Region: rbfA; PRK00521 755731004365 Exopolyphosphatase-related proteins [General function prediction only]; Region: COG0618 755731004366 DHH family; Region: DHH; pfam01368 755731004367 tRNA pseudouridine synthase B; Provisional; Region: truB; PRK00130 755731004368 Pseudouridine synthase, Escherichia coli TruB like; Region: PseudoU_synth_EcTruB; cd02573 755731004369 RNA binding site [nucleotide binding]; other site 755731004370 active site 755731004371 bifunctional riboflavin kinase/FMN adenylyltransferase; Reviewed; Region: PRK05627 755731004372 FAD synthetase, N-terminal domain of the bifunctional enzyme; Region: FAD_synthetase_N; cd02064 755731004373 active site 755731004374 Riboflavin kinase; Region: Flavokinase; pfam01687 755731004375 Hydrogenase maturation factor [Posttranslational modification, protein turnover, chaperones]; Region: HypF; COG0068 755731004376 Acylphosphatase; Region: Acylphosphatase; pfam00708 755731004377 HypF finger; Region: zf-HYPF; pfam07503 755731004378 HypF finger; Region: zf-HYPF; pfam07503 755731004379 Telomere recombination; Region: Sua5_yciO_yrdC; pfam01300 755731004380 Carbamoyltransferase; Region: CmcH_NodU; pfam02543 755731004381 HupF/HypC family; Region: HupF_HypC; pfam01455 755731004382 hydrogenase expression/formation protein HypD; Region: hypD; TIGR00075 755731004383 hydrogenase isoenzymes formation protein HypD; Provisional; Region: PRK15062 755731004384 HypE (Hydrogenase expression/formation protein). HypE is involved in Ni-Fe hydrogenase biosynthesis. HypE dehydrates its own carbamoyl moiety in an ATP-dependent process to yield the enzyme thiocyanate. The N-terminal domain of HypE is related to the...; Region: HypE; cd02197 755731004385 dimerization interface [polypeptide binding]; other site 755731004386 hydrogenase expression/formation protein HypE; Region: hypE; TIGR02124 755731004387 ATP binding site [chemical binding]; other site 755731004388 ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136 755731004389 ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255 755731004390 Walker A/P-loop; other site 755731004391 ATP binding site [chemical binding]; other site 755731004392 Q-loop/lid; other site 755731004393 ABC transporter signature motif; other site 755731004394 Walker B; other site 755731004395 D-loop; other site 755731004396 H-loop/switch region; other site 755731004397 Yip1 domain; Region: Yip1; pfam04893 755731004398 RND family efflux transporter, MFP subunit; Region: RND_mfp; TIGR01730 755731004399 HlyD family secretion protein; Region: HlyD_3; pfam13437 755731004400 MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704 755731004401 ABC-type antimicrobial peptide transport system, permease component [Defense mechanisms]; Region: SalY; COG0577 755731004402 FtsX-like permease family; Region: FtsX; pfam02687 755731004403 Predicted Zn-dependent peptidases [General function prediction only]; Region: PqqL; COG0612 755731004404 Peptidase M16 inactive domain; Region: Peptidase_M16_C; pfam05193 755731004405 Predicted Zn-dependent peptidases [General function prediction only]; Region: PqqL; COG0612 755731004406 Insulinase (Peptidase family M16); Region: Peptidase_M16; pfam00675 755731004407 Peptidase M16 inactive domain; Region: Peptidase_M16_C; pfam05193 755731004408 prolipoprotein diacylglyceryl transferase; Reviewed; Region: PRK12437 755731004409 rod shape-determining protein RodA; Region: rodA_shape; TIGR02210 755731004410 cell division protein MraZ; Reviewed; Region: PRK00326 755731004411 MraZ protein; Region: MraZ; pfam02381 755731004412 MraZ protein; Region: MraZ; pfam02381 755731004413 MraW methylase family; Region: Methyltransf_5; pfam01795 755731004414 16S rRNA m(4)C1402 methyltranserfase; Provisional; Region: PRK00050 755731004415 Cell division protein FtsL; Region: FtsL; cl11433 755731004416 stage V sporulation protein D; Region: spoVD_pbp; TIGR02214 755731004417 Penicillin-binding Protein dimerisation domain; Region: PBP_dimer; pfam03717 755731004418 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; pfam00905 755731004419 PASTA domain of PBP2x-like proteins, first repeat. Penicillin-binding proteins (PBPs) are the major targets for beta-lactam antibiotics, like penicillins and cephalosporins. Beta-lactam antibiotics specifically inhibit transpeptidase activity by...; Region: PASTA_Pbp2x-like_1; cd06576 755731004420 PASTA domain of PBP2x-like proteins, second repeat. Penicillin-binding proteins (PBPs) are the major targets for beta-lactam antibiotics, like penicillins and cephalosporins. Beta-lactam antibiotics specifically inhibit transpeptidase activity by...; Region: PASTA_Pbp2x-like_2; cd06575 755731004421 UDP-N-acetylmuramoylalanyl-D-glutamate--2, 6-diaminopimelate ligase; Provisional; Region: murE; PRK00139 755731004422 Mur ligase family, catalytic domain; Region: Mur_ligase; pfam01225 755731004423 Mur ligase middle domain; Region: Mur_ligase_M; pfam08245 755731004424 Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875 755731004425 UDP-N-acetylmuramyl pentapeptide synthase [Cell envelope biogenesis, outer membrane]; Region: MurF; COG0770 755731004426 Mur ligase family, catalytic domain; Region: Mur_ligase; pfam01225 755731004427 Mur ligase middle domain; Region: Mur_ligase_M; pfam08245 755731004428 Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875 755731004429 phospho-N-acetylmuramoyl-pentapeptide-transferase; Provisional; Region: mraY; PRK00108 755731004430 Phospho-N-acetylmuramoyl-pentapeptide-transferase (mraY) is an enzyme responsible for the formation of the first lipid intermediate in the synthesis of bacterial cell wall peptidoglycan. It catalyzes the formation of...; Region: GT_MraY; cd06852 755731004431 Mg++ binding site [ion binding]; other site 755731004432 putative catalytic motif [active] 755731004433 putative substrate binding site [chemical binding]; other site 755731004434 Cell cycle protein; Region: FTSW_RODA_SPOVE; cl00511 755731004435 undecaprenyldiphospho-muramoylpentapeptide beta-N- acetylglucosaminyltransferase; Provisional; Region: murG; PRK00726 755731004436 MurG is an N-acetylglucosaminyltransferase, the last enzyme involved in the intracellular phase of peptidoglycan biosynthesis. It transfers N-acetyl-D-glucosamine (GlcNAc) from UDP-GlcNAc to the C4 hydroxyl of a lipid-linked N-acetylmuramoyl pentapeptide...; Region: GT1_MurG; cd03785 755731004437 active site 755731004438 homodimer interface [polypeptide binding]; other site 755731004439 Small, acid-soluble spore proteins, alpha/beta type; Region: SASP; pfam00269 755731004440 uracil transporter; Provisional; Region: PRK10720 755731004441 diacylglycerol glucosyltransferase; Provisional; Region: PRK13609 755731004442 Monogalactosyldiacylglycerol (MGDG) synthase; Region: MGDG_synth; pfam06925 755731004443 Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013 755731004444 Beta-lactamase enzyme family; Region: Beta-lactamase2; cl17872 755731004445 D-alanyl-D-alanine carboxypeptidase [Cell envelope biogenesis, outer membrane]; Region: DacC; COG1686 755731004446 Penicillin-binding protein 5, C-terminal domain; Region: PBP5_C; pfam07943 755731004447 Fe-S oxidoreductase [Energy production and conversion]; Region: COG1032 755731004448 B12 binding domain_like associated with radical SAM domain. This domain shows similarity with B12 (adenosylcobamide) binding domains found in several enzymes, such as glutamate mutase, methionine synthase and methylmalonyl-CoA mutase, but it lacks the...; Region: radical_SAM_B12_BD; cd02068 755731004449 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 755731004450 FeS/SAM binding site; other site 755731004451 Protein of unknown function (DUF4080); Region: DUF4080; pfam13311 755731004452 Putative Ser protein kinase [Signal transduction mechanisms]; Region: PrkA; COG2766 755731004453 AAA ATPase domain; Region: AAA_16; pfam13191 755731004454 PrkA serine protein kinase C-terminal domain; Region: PrkA; pfam06798 755731004455 hypothetical protein; Provisional; Region: PRK05325 755731004456 Uncharacterized conserved protein [Function unknown]; Region: SpoVR; COG2719 755731004457 SpoVR like protein; Region: SpoVR; pfam04293 755731004458 heat shock protein 90; Provisional; Region: PRK05218 755731004459 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 755731004460 ATP binding site [chemical binding]; other site 755731004461 Mg2+ binding site [ion binding]; other site 755731004462 G-X-G motif; other site 755731004463 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 755731004464 Acyl-coenzyme A synthetases/AMP-(fatty) acid ligases [Lipid metabolism]; Region: Acs; COG0365 755731004465 acyl-activating enzyme (AAE) consensus motif; other site 755731004466 AMP binding site [chemical binding]; other site 755731004467 active site 755731004468 CoA binding site [chemical binding]; other site 755731004469 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 755731004470 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 755731004471 non-specific DNA binding site [nucleotide binding]; other site 755731004472 salt bridge; other site 755731004473 sequence-specific DNA binding site [nucleotide binding]; other site 755731004474 Cupin domain; Region: Cupin_2; pfam07883 755731004475 HAMP domain; Region: HAMP; pfam00672 755731004476 dimerization interface [polypeptide binding]; other site 755731004477 Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer); Region: MA; smart00283 755731004478 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 755731004479 dimer interface [polypeptide binding]; other site 755731004480 putative CheW interface [polypeptide binding]; other site 755731004481 c-di-GMP phosphodiesterase class II (HD-GYP domain) [Signal transduction mechanisms]; Region: COG2206 755731004482 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 755731004483 Zn2+ binding site [ion binding]; other site 755731004484 Mg2+ binding site [ion binding]; other site 755731004485 Transcriptional regulator [Transcription]; Region: LysR; COG0583 755731004486 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 755731004487 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cd05466 755731004488 dimerization interface [polypeptide binding]; other site 755731004489 phosphoribosylformylglycinamidine synthase, clade II; Region: FGAM-synthase; TIGR01857 755731004490 AIR (aminoimidazole ribonucleotide) synthase related protein. This family includes Hydrogen expression/formation protein HypE, AIR synthases, FGAM (formylglycinamidine ribonucleotide) synthase and Selenophosphate synthetase (SelD). The N-terminal domain...; Region: PurM-like; cl10019 755731004491 PurL subunit of the formylglycinamide ribonucleotide amidotransferase (FGAR-AT), first repeat. FGAR-AT catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to formylglycinamidine ribonucleotide (FGAM), ADP; Region: PurL_repeat1; cd02203 755731004492 dimerization interface [polypeptide binding]; other site 755731004493 ATP binding site [chemical binding]; other site 755731004494 PurL subunit of the formylglycinamide ribonucleotide amidotransferase (FGAR-AT), second repeat. FGAR-AT catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to formylglycinamidine ribonucleotide (FGAM), ADP; Region: PurL_repeat2; cd02204 755731004495 dimerization interface [polypeptide binding]; other site 755731004496 ATP binding site [chemical binding]; other site 755731004497 Type 1 glutamine amidotransferase (GATase1)-like domain found in Formylglycinamide ribonucleotide amidotransferase; Region: GATase1_FGAR_AT; cd01740 755731004498 putative active site [active] 755731004499 catalytic triad [active] 755731004500 Sugar phosphate isomerases/epimerases [Carbohydrate transport and metabolism]; Region: IolE; COG1082 755731004501 AP endonuclease family 2; These endonucleases play a role in DNA repair. Cleave phosphodiester bonds at apurinic or apyrimidinic sites; the alignment also contains hexulose-6-phosphate isomerases, enzymes that catalyze the epimerization of...; Region: AP2Ec; cl12060 755731004502 AP (apurinic/apyrimidinic) site pocket; other site 755731004503 DNA interaction; other site 755731004504 Metal-binding active site; metal-binding site 755731004505 Dockerin type I repeat; Region: Dockerin_1; pfam00404 755731004506 Dockerin type I repeat; Region: Dockerin_1; pfam00404 755731004507 AAA domain; Region: AAA_31; pfam13614 755731004508 Flp pilus assembly protein, ATPase CpaF [Intracellular trafficking and secretion]; Region: CpaF; COG4962 755731004509 Type IV secretory pathway component VirB11, and related ATPases. The homohexamer, VirB11 is one of eleven Vir proteins, which are required for T-pilus biogenesis and virulence in the transfer of T-DNA from the Ti (tumor-inducing) plasmid of bacterial to...; Region: VirB11-like_ATPase; cd01130 755731004510 ATP binding site [chemical binding]; other site 755731004511 Walker A motif; other site 755731004512 hexamer interface [polypeptide binding]; other site 755731004513 Walker B motif; other site 755731004514 Flp pilus assembly protein TadB [Intracellular trafficking and secretion]; Region: TadB; COG4965 755731004515 Flp pilus assembly protein TadC [Cell motility and secretion / Intracellular trafficking and secretion]; Region: TadC; COG2064 755731004516 Type II secretion system (T2SS), protein F; Region: T2SF; pfam00482 755731004517 SIR2 superfamily of proteins includes silent information regulator 2 (Sir2) enzymes which catalyze NAD+-dependent protein/histone deacetylation, where the acetyl group from the lysine epsilon-amino group is transferred to the ADP-ribose moiety of NAD+; Region: SIR2; cl00195 755731004518 SIR2 superfamily of proteins includes silent information regulator 2 (Sir2) enzymes which catalyze NAD+-dependent protein/histone deacetylation, where the acetyl group from the lysine epsilon-amino group is transferred to the ADP-ribose moiety of NAD+; Region: SIR2; cl00195 755731004519 SRP54-type protein, GTPase domain; Region: SRP54; smart00962 755731004520 Helix-turn-helix domain; Region: HTH_17; pfam12728 755731004521 Serine/threonine protein kinase [General function prediction only / Signal transduction mechanisms / Transcription / DNA replication, recombination, and repair]; Region: SPS1; COG0515 755731004522 Catalytic domain of Protein Kinases; Region: PKc; cd00180 755731004523 active site 755731004524 ATP binding site [chemical binding]; other site 755731004525 substrate binding site [chemical binding]; other site 755731004526 activation loop (A-loop); other site 755731004527 Predicted ATPase [General function prediction only]; Region: COG5293 755731004528 Uncharacterized protein conserved in bacteria (DUF2326); Region: DUF2326; pfam10088 755731004529 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 755731004530 non-specific DNA binding site [nucleotide binding]; other site 755731004531 salt bridge; other site 755731004532 sequence-specific DNA binding site [nucleotide binding]; other site 755731004533 DNA breaking-rejoining enzymes, intergrase/recombinases, C-terminal catalytic domain. The tyrosine recombinase/integrase family share the same catalytic domain containing six conserved active site residues. The best-studied members of this diverse family...; Region: INT_REC_C; cd01182 755731004534 active site 755731004535 catalytic residues [active] 755731004536 DNA binding site [nucleotide binding] 755731004537 Int/Topo IB signature motif; other site 755731004538 Helix-turn-helix domain of Hin and related proteins, a family of DNA-binding domains unique to bacteria and represented by the Hin protein of Salmonella. The basic HTH domain is a simple fold comprised of three core helices that form a right-handed...; Region: HTH_Hin_like; cl17393 755731004539 tyrosine recombinase XerD; Region: recomb_XerD; TIGR02225 755731004540 DNA breaking-rejoining enzymes, intergrase/recombinases, C-terminal catalytic domain. The tyrosine recombinase/integrase family share the same catalytic domain containing six conserved active site residues. The best-studied members of this diverse family...; Region: INT_REC_C; cd01182 755731004541 active site 755731004542 catalytic residues [active] 755731004543 DNA binding site [nucleotide binding] 755731004544 Int/Topo IB signature motif; other site 755731004545 TadE-like protein; Region: TadE; pfam07811 755731004546 Type II secretory pathway, prepilin signal peptidase PulO and related peptidases [Cell motility and secretion / Posttranslational modification, protein turnover, chaperones / Intracellular trafficking and secretion]; Region: PulO; COG1989 755731004547 Type IV leader peptidase family; Region: Peptidase_A24; pfam01478 755731004548 Forkhead associated domain (FHA); found in eukaryotic and prokaryotic proteins. Putative nuclear signalling domain. FHA domains may bind phosphothreonine, phosphoserine and sometimes phosphotyrosine. In eukaryotes, many FHA domain-containing proteins...; Region: FHA; cd00060 755731004549 phosphopeptide binding site; other site 755731004550 Predicted esterase of the alpha-beta hydrolase superfamily [General function prediction only]; Region: COG4667 755731004551 Hypothetical patatin similar to yjju protein of Escherichia coli; Region: Pat_hypo_Ecoli_yjju_like; cd07208 755731004552 active site 755731004553 nucleophile elbow; other site 755731004554 Predicted membrane protein [Function unknown]; Region: COG2510 755731004555 Uncharacterized conserved protein [Function unknown]; Region: COG0432 755731004556 Deoxycytidylate deaminase domain. Deoxycytidylate deaminase catalyzes the deamination of dCMP to dUMP, providing the nucleotide substrate for thymidylate synthase. The enzyme binds Zn++, which is required for catalytic activity. The activity of the...; Region: deoxycytidylate_deaminase; cd01286 755731004557 catalytic motif [active] 755731004558 Zn binding site [ion binding]; other site 755731004559 Putative amidase domain; Region: Amidase_6; pfam12671 755731004560 Spore germination protein; Region: Spore_permease; cl17796 755731004561 germination protein, Ger(x)C family; Region: spore_ger_x_C; TIGR02887 755731004562 Spore germination B3/ GerAC like, C-terminal; Region: Spore_GerAC; pfam05504 755731004563 Bacillus/Clostridium GerA spore germination protein; Region: GerA; pfam03323 755731004564 Syntaxin N-terminus domain; syntaxins are nervous system-specific proteins implicated in the docking of synaptic vesicles with the presynaptic plasma membrane; they are a family of receptors for intracellular transport vesicles; each target membrane may...; Region: SynN; cl00143 755731004565 interdomain interaction site; other site 755731004566 3D domain; Region: 3D; cl01439 755731004567 Dihydrodipicolinate reductase [Amino acid transport and metabolism]; Region: DapB; COG0289 755731004568 Dihydrodipicolinate reductase, N-terminus; Region: DapB_N; pfam01113 755731004569 Dihydrodipicolinate reductase, C-terminus; Region: DapB_C; pfam05173 755731004570 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3666 755731004571 Transposase DDE domain; Region: DDE_Tnp_1_6; pfam13751 755731004572 D-alanyl-D-alanine carboxypeptidase; Region: Peptidase_S11; pfam00768 755731004573 Beta-lactamase enzyme family; Region: Beta-lactamase2; cl17872 755731004574 Penicillin-binding protein 5, C-terminal domain; Region: PBP5_C; smart00936 755731004575 Bacillus/Clostridium GerA spore germination protein; Region: GerA; pfam03323 755731004576 Spore germination protein; Region: Spore_permease; cl17796 755731004577 germination protein, Ger(x)C family; Region: spore_ger_x_C; TIGR02887 755731004578 Spore germination B3/ GerAC like, C-terminal; Region: Spore_GerAC; pfam05504 755731004579 ACT domains of the lysine-sensitive aspartokinase isoenzyme AKII and related proteins; Region: ACT_AK-LysC-DapG-like_1; cd04891 755731004580 ACT domains of the lysine-sensitive, aspartokinase (AK) isoenzyme AKII of Bacillus subtilis (BS) strain 168 and related domains; Region: ACT_AKii-LysC-BS-like_2; cd04936 755731004581 putative allosteric regulatory residue; other site 755731004582 dihydrodipicolinate reductase; Provisional; Region: PRK00048 755731004583 Dihydrodipicolinate reductase, N-terminus; Region: DapB_N; pfam01113 755731004584 Dihydrodipicolinate reductase, C-terminus; Region: DapB_C; pfam05173 755731004585 Dihydrodipicolinate synthase (DHDPS); Region: DHDPS; cd00950 755731004586 dihydrodipicolinate synthase; Region: dapA; TIGR00674 755731004587 dimer interface [polypeptide binding]; other site 755731004588 active site 755731004589 catalytic residue [active] 755731004590 Stage II sporulation protein; Region: SpoIID; pfam08486 755731004591 SpoIID/LytB domain; Region: SpoIID_LytB; TIGR02669 755731004592 aspartate kinase; Reviewed; Region: PRK09034 755731004593 AAK_AKiii-YclM-BS: Amino Acid Kinase Superfamily (AAK), AKiii-YclM-BS; this CD includes the N-terminal catalytic aspartokinase (AK) domain of the lysine plus threonine-sensitive aspartokinase isoenzyme AKIII, a monofunctional class enzyme found in...; Region: AAK_AKiii-YclM-BS; cd04245 755731004594 putative catalytic residues [active] 755731004595 putative nucleotide binding site [chemical binding]; other site 755731004596 putative aspartate binding site [chemical binding]; other site 755731004597 ACT domains located C-terminal to the catalytic domain of the lysine plus threonine-sensitive aspartokinase isoenzyme AKIII; Region: ACT_AKiii-YclM-BS_1; cd04911 755731004598 allosteric regulatory residue; other site 755731004599 ACT domains located C-terminal to the catalytic domain of the lysine plus threonine-sensitive aspartokinase isoenzyme AKIII; Region: ACT_AKiii-YclM-BS_2; cd04916 755731004600 S-adenosylmethionine:tRNA ribosyltransferase-isomerase; Provisional; Region: queA; PRK00147 755731004601 S-adenosylmethionine:tRNA ribosyltransferase-isomerase; Region: queA; TIGR00113 755731004602 queuine tRNA-ribosyltransferase; Provisional; Region: tgt; PRK00112 755731004603 Queuine/archaeosine tRNA-ribosyltransferase [Translation, ribosomal structure and biogenesis]; Region: Tgt; COG0343 755731004604 Preprotein translocase subunit; Region: YajC; pfam02699 755731004605 Protein of unknown function (DUF3792); Region: DUF3792; pfam12670 755731004606 Protein of unknown function (DUF4001); Region: DUF4001; pfam13165 755731004607 SCIFF radical SAM maturase; Region: rSAM_six_Cys; TIGR03974 755731004608 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 755731004609 FeS/SAM binding site; other site 755731004610 radical SAM additional 4Fe4S-binding SPASM domain; Region: rSAM_more_4Fe4S; TIGR04085 755731004611 Carbonic anhydrases/acetyltransferases, isoleucine patch superfamily [General function prediction only]; Region: PaaY; COG0663 755731004612 Gamma carbonic anhydrase-like: This family is composed of gamma carbonic anhydrase (CA), Ferripyochelin Binding Protein (FBP), E. coli paaY protein, and similar proteins. CAs are zinc-containing enzymes that catalyze the reversible hydration of carbon...; Region: LbH_gamma_CA_like; cd04645 755731004613 trimer interface [polypeptide binding]; other site 755731004614 putative metal binding site [ion binding]; other site 755731004615 protein-export membrane protein SecD; Region: secD; TIGR01129 755731004616 protein-export membrane protein, SecD/SecF family; Region: 2A0604s01; TIGR00916 755731004617 preprotein translocase subunit SecF; Reviewed; Region: secF; PRK13022 755731004618 Protein export membrane protein; Region: SecD_SecF; pfam02355 755731004619 Solute carrier families 5 and 6-like; solute binding domain; Region: SLC5-6-like_sbd; cl00456 755731004620 DNA primase; Validated; Region: dnaG; PRK05667 755731004621 CHC2 zinc finger; Region: zf-CHC2; pfam01807 755731004622 DNA primase catalytic core, N-terminal domain; Region: Toprim_N; pfam08275 755731004623 TOPRIM_DnaG_primases: The topoisomerase-primase (TORPIM) nucleotidyl transferase/hydrolase domain found in the active site regions of proteins similar to Escherichia coli DnaG. Primases synthesize RNA primers for the initiation of DNA replication. DnaG...; Region: TOPRIM_DnaG_primases; cd03364 755731004624 active site 755731004625 metal binding site [ion binding]; metal-binding site 755731004626 interdomain interaction site; other site 755731004627 DnaB-helicase binding domain of primase; Region: DnaB_bind; pfam10410 755731004628 RNA polymerase sigma factor RpoD; Validated; Region: PRK09210 755731004629 Sigma-70 factor, region 1.1; Region: Sigma70_r1_1; pfam03979 755731004630 Sigma-70 factor, region 1.2; Region: Sigma70_r1_2; pfam00140 755731004631 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 755731004632 Sigma-70 region 3; Region: Sigma70_r3; pfam04539 755731004633 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 755731004634 DNA binding residues [nucleotide binding] 755731004635 Predicted SAM-dependent methyltransferase [General function prediction only]; Region: COG2384 755731004636 Family of unknown function (DUF633); Region: DUF633; pfam04816 755731004637 Uncharacterized conserved protein [Function unknown]; Region: COG0327 755731004638 NIF3 (NGG1p interacting factor 3); Region: NIF3; pfam01784 755731004639 Cell division protein ZapA; Region: ZapA; cl01146 755731004640 4Fe-4S single cluster domain; Region: Fer4_15; pfam13459 755731004641 Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281 755731004642 active site 755731004643 Multimeric flavodoxin WrbA [General function prediction only]; Region: WrbA; COG0655 755731004644 NADPH-dependent FMN reductase; Region: FMN_red; pfam03358 755731004645 Dinucleotide-utilizing enzymes involved in molybdopterin and thiamine biosynthesis family 1 [Coenzyme metabolism]; Region: COG1179 755731004646 Family of activating enzymes (E1) of ubiquitin-like proteins related to the E.coli hypothetical protein ygdL. The common reaction mechanism catalyzed by E1-like enzymes begins with a nucleophilic attack of the C-terminal carboxylate of the ubiquitin-like...; Region: YgdL_like; cd00755 755731004647 putative ATP binding site [chemical binding]; other site 755731004648 putative substrate interface [chemical binding]; other site 755731004649 The Fer4_NifH superfamily contains a variety of proteins which share a common ATP-binding domain. Functionally, proteins in this superfamily use the energy from hydrolysis of NTP to transfer electron or ion; Region: Fer4_NifH; cl17203 755731004650 DNA-binding domain of DNA mismatch repair MUTS family; Region: MUTSd; smart00533 755731004651 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 755731004652 Walker A/P-loop; other site 755731004653 ATP binding site [chemical binding]; other site 755731004654 Q-loop/lid; other site 755731004655 ABC transporter signature motif; other site 755731004656 Walker B; other site 755731004657 D-loop; other site 755731004658 H-loop/switch region; other site 755731004659 4Fe-4S dicluster domain; Region: Fer4_10; pfam13237 755731004660 The HCP family of iron-sulfur proteins includes hybrid cluster protein (HCP), acetyl-CoA synthase (ACS), and carbon monoxide dehydrogenase (CODH), all of which contain [Fe4-S4] metal clusters at their active sites. These proteins have a conserved...; Region: HCP_like; cl14655 755731004661 2-ketoisovalerate ferredoxin reductase; Validated; Region: PRK07119 755731004662 Pyrimidine (PYR) binding domain of pyruvate ferredoxin oxidoreductase (PFOR), indolepyruvate ferredoxin oxidoreductase alpha subunit (IOR-alpha), and related proteins; Region: TPP_PYR_PFOR_IOR-alpha_like; cd07034 755731004663 dimer interface [polypeptide binding]; other site 755731004664 PYR/PP interface [polypeptide binding]; other site 755731004665 TPP binding site [chemical binding]; other site 755731004666 substrate binding site [chemical binding]; other site 755731004667 Transketolase, C-terminal domain; Region: Transketolase_C; pfam02780 755731004668 Pyruvate:ferredoxin oxidoreductase and related 2-oxoacid:ferredoxin oxidoreductases, beta subunit [Energy production and conversion]; Region: PorB; COG1013 755731004669 Thiamine pyrophosphate (TPP family), 2-oxoglutarate ferredoxin oxidoreductase (OGFOR) subfamily, TPP-binding module; OGFOR catalyzes the oxidative decarboxylation of 2-oxo-acids, with ferredoxin acting as an electron acceptor. In the TCA cycle, OGFOR...; Region: TPP_OGFOR; cd03375 755731004670 TPP-binding site [chemical binding]; other site 755731004671 Pyruvate:ferredoxin oxidoreductase and related 2-oxoacid:ferredoxin oxidoreductases, gamma subunit [Energy production and conversion]; Region: PorG; COG1014 755731004672 2-oxoglutarate ferredoxin oxidoreductase subunit gamma; Validated; Region: PRK08537 755731004673 ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136 755731004674 ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255 755731004675 Walker A/P-loop; other site 755731004676 ATP binding site [chemical binding]; other site 755731004677 Q-loop/lid; other site 755731004678 ABC transporter signature motif; other site 755731004679 Walker B; other site 755731004680 D-loop; other site 755731004681 H-loop/switch region; other site 755731004682 FtsX-like permease family; Region: FtsX; pfam02687 755731004683 ABC-type antimicrobial peptide transport system, permease component [Defense mechanisms]; Region: SalY; COG0577 755731004684 FtsX-like permease family; Region: FtsX; pfam02687 755731004685 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 755731004686 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 755731004687 active site 755731004688 phosphorylation site [posttranslational modification] 755731004689 intermolecular recognition site; other site 755731004690 dimerization interface [polypeptide binding]; other site 755731004691 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 755731004692 DNA binding site [nucleotide binding] 755731004693 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 755731004694 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 755731004695 dimer interface [polypeptide binding]; other site 755731004696 phosphorylation site [posttranslational modification] 755731004697 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 755731004698 ATP binding site [chemical binding]; other site 755731004699 Mg2+ binding site [ion binding]; other site 755731004700 G-X-G motif; other site 755731004701 Uncharacterized protein related to glutamine synthetase [General function prediction only]; Region: COG3968 755731004702 Glutamine synthetase type III N terminal; Region: GSIII_N; pfam12437 755731004703 Glutamine synthetase, catalytic domain; Region: Gln-synt_C; pfam00120 755731004704 Transglutaminase-like enzymes, putative cysteine proteases [Amino acid transport and metabolism]; Region: COG1305 755731004705 Transglutaminase-like superfamily; Region: Transglut_core; pfam01841 755731004706 YmaF family; Region: YmaF; pfam12788 755731004707 Xaa-Pro aminopeptidase [Amino acid transport and metabolism]; Region: PepP; COG0006 755731004708 Creatinase/Prolidase N-terminal domain; Region: Creatinase_N; pfam01321 755731004709 A family including aminopeptidase P, aminopeptidase M, and prolidase. Also known as metallopeptidase family M24. This family of enzymes is able to cleave amido-, imido- and amidino-containing bonds. Members exibit relatively narrow substrate specificity...; Region: APP_MetAP; cd01066 755731004710 active site 755731004711 Catalytic NodB homology domain of rhizobial NodB-like proteins; Region: CE4_NodB_like_6s_7s; cd10917 755731004712 NodB motif; other site 755731004713 active site 755731004714 catalytic site [active] 755731004715 metal binding site [ion binding]; metal-binding site 755731004716 Restriction endonuclease; Region: Mrr_cat; pfam04471 755731004717 ExsB is a transcription regulator related protein. It is a subfamily of a Adenosine nucleotide binding superfamily of proteins. This protein family is represented by a single member in nearly every completed large (> 1000 genes) prokaryotic genome. In...; Region: ExsB; cd01995 755731004718 Ligand Binding Site [chemical binding]; other site 755731004719 phiLC3 phage and phage-related integrases, site-specific recombinases, DNA breaking-rejoining enzymes, C-terminal catalytic domain. This CD includes various bacterial (mainly gram positive) and phage integrases, including those similar to Lactococcus...; Region: INT_phiLC3_C; cd01189 755731004720 Int/Topo IB signature motif; other site 755731004721 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 755731004722 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 755731004723 non-specific DNA binding site [nucleotide binding]; other site 755731004724 salt bridge; other site 755731004725 sequence-specific DNA binding site [nucleotide binding]; other site 755731004726 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 755731004727 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 755731004728 non-specific DNA binding site [nucleotide binding]; other site 755731004729 salt bridge; other site 755731004730 sequence-specific DNA binding site [nucleotide binding]; other site 755731004731 Helix-turn-helix domain; Region: HTH_17; cl17695 755731004732 N-terminal phage replisome organiser (Phage_rep_org_N); Region: Phage_rep_org_N; cl09889 755731004733 The Ntn hydrolases (N-terminal nucleophile) are a diverse superfamily of of enzymes that are activated autocatalytically via an N-terminally lcated nucleophilic amino acid. N-terminal nucleophile (NTN-) hydrolase superfamily, which contains a...; Region: Ntn_hydrolase; cl00467 755731004734 active site 755731004735 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 755731004736 ATPases associated with a variety of cellular activities; Region: AAA; smart00382 755731004737 Walker A motif; other site 755731004738 ATP binding site [chemical binding]; other site 755731004739 Walker B motif; other site 755731004740 arginine finger; other site 755731004741 INT_SG3, DNA breaking-rejoining enzymes, integrase/recombinases subgroup 3, catalytic domain. The CD contains various predicted bacterial and phage integrase/recombinase sequences for which not much experimental characterization is available; Region: INT_SG3_C; cd01186 755731004742 Int/Topo IB signature motif; other site 755731004743 valyl-tRNA synthetase; Reviewed; Region: valS; PRK05729 755731004744 phage major capsid protein, HK97 family; Region: major_cap_HK97; TIGR01554 755731004745 Phage capsid family; Region: Phage_capsid; pfam05065 755731004746 Adenine nucleotide alpha hydrolases superfamily including N type ATP PPases, ATP sulphurylases Universal Stress Response protein and electron transfer flavoprotein (ETF). The domain forms a apha/beta/apha fold which binds to Adenosine nucleotide; Region: AANH_like; cl00292 755731004747 TatD like proteins; E.coli TatD is a cytoplasmic protein, shown to have magnesium dependent DNase activity; Region: TatD_DNAse; cd01310 755731004748 active site 755731004749 Helix-turn-helix domain; Region: HTH_17; pfam12728 755731004750 Bacterial protein of unknown function (DUF881); Region: DUF881; pfam05949 755731004751 Bacterial protein of unknown function (DUF881); Region: DUF881; pfam05949 755731004752 delta-lactam-biosynthetic de-N-acetylase; Region: spore_pdaA; TIGR02884 755731004753 Catalytic NodB homology domain of Bacillus subtilis polysaccharide deacetylase PdaA, and its bacterial homologs; Region: CE4_BsPdaA_like; cd10948 755731004754 NodB motif; other site 755731004755 active site 755731004756 catalytic site [active] 755731004757 Cd binding site [ion binding]; other site 755731004758 YabP family; Region: YabP; cl06766 755731004759 sporulation protein YqfD; Region: spore_yqfD; TIGR02876 755731004760 Putative stage IV sporulation protein YqfD; Region: YqfD; pfam06898 755731004761 Phosphate starvation-inducible protein PhoH, predicted ATPase [Signal transduction mechanisms]; Region: PhoH; COG1702 755731004762 PhoH-like protein; Region: PhoH; pfam02562 755731004763 Predicted membrane-associated HD superfamily hydrolase [General function prediction only]; Region: COG1480 755731004764 7TM receptor with intracellular HD hydrolase; Region: 7TM-7TMR_HD; pfam07698 755731004765 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 755731004766 Zn2+ binding site [ion binding]; other site 755731004767 Mg2+ binding site [ion binding]; other site 755731004768 metal-binding heat shock protein; Provisional; Region: PRK00016 755731004769 Prokaryotic diacylglycerol kinase; Region: DAGK_prokar; pfam01219 755731004770 Cytidine deaminase zinc-binding domain. These enzymes are Zn dependent. The zinc ion in the active site plays a central role in the proposed catalytic mechanism, activating a water molecule to form a hydroxide ion that performs a nucleophilic attack on...; Region: cytidine_deaminase; cd01283 755731004771 active site 755731004772 catalytic motif [active] 755731004773 Zn binding site [ion binding]; other site 755731004774 GTPase Era; Reviewed; Region: era; PRK00089 755731004775 E. coli Ras-like protein (Era) is a multifunctional GTPase; Region: Era; cd04163 755731004776 G1 box; other site 755731004777 GTP/Mg2+ binding site [chemical binding]; other site 755731004778 Switch I region; other site 755731004779 G2 box; other site 755731004780 Switch II region; other site 755731004781 G3 box; other site 755731004782 G4 box; other site 755731004783 G5 box; other site 755731004784 KH domain; Region: KH_2; pfam07650 755731004785 YqzL-like protein; Region: YqzL; pfam14006 755731004786 Recombination protein O N terminal; Region: RecO_N; pfam11967 755731004787 DNA repair protein RecO; Region: reco; TIGR00613 755731004788 Recombination protein O C terminal; Region: RecO_C; pfam02565 755731004789 cardiolipin synthase; Region: bac_cardiolipin; TIGR04265 755731004790 Phospholipase_D-nuclease N-terminal; Region: PLDc_N; pfam13396 755731004791 Catalytic domain, repeat 1, of bacterial cardiolipin synthase and similar proteins; Region: PLDc_CLS_1; cd09110 755731004792 putative active site [active] 755731004793 catalytic site [active] 755731004794 catalytic domain repeat 2 of bacterial cardiolipin synthase and similar proteins; Region: PLDc_CLS_2; cd09112 755731004795 putative active site [active] 755731004796 catalytic site [active] 755731004797 Predicted O-acyltransferase [General function prediction only]; Region: COG3274 755731004798 Acyltransferase family; Region: Acyl_transf_3; pfam01757 755731004799 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 755731004800 Zn2+ binding site [ion binding]; other site 755731004801 Mg2+ binding site [ion binding]; other site 755731004802 ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132 755731004803 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 755731004804 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 755731004805 Walker A/P-loop; other site 755731004806 ATP binding site [chemical binding]; other site 755731004807 Q-loop/lid; other site 755731004808 ABC transporter signature motif; other site 755731004809 Walker B; other site 755731004810 D-loop; other site 755731004811 H-loop/switch region; other site 755731004812 ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132 755731004813 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 755731004814 ATP-binding cassette domain of glucan transporter and related proteins, subfamily C; Region: ABCC_Glucan_exporter_like; cd03254 755731004815 Walker A/P-loop; other site 755731004816 ATP binding site [chemical binding]; other site 755731004817 Q-loop/lid; other site 755731004818 ABC transporter signature motif; other site 755731004819 Walker B; other site 755731004820 D-loop; other site 755731004821 H-loop/switch region; other site 755731004822 Bacterial protein of unknown function (DUF896); Region: DUF896; pfam05979 755731004823 Chemotaxis signal transduction protein [Cell motility and secretion / Signal transduction mechanisms]; Region: CheW; COG0835 755731004824 YmaF family; Region: YmaF; pfam12788 755731004825 GTP-binding protein YchF; Reviewed; Region: PRK09601 755731004826 YchF GTPase; Region: YchF; cd01900 755731004827 G1 box; other site 755731004828 GTP/Mg2+ binding site [chemical binding]; other site 755731004829 Switch I region; other site 755731004830 G2 box; other site 755731004831 Switch II region; other site 755731004832 G3 box; other site 755731004833 G4 box; other site 755731004834 G5 box; other site 755731004835 TGS_YchF_C: This subfamily represents TGS domain-containing YchF GTP-binding protein, a universally conserved GTPase whose function is unknown. The N-terminal domain of the YchF protein belongs to the Obg-like family of GTPases, and some members of the...; Region: TGS_YchF_C; cd04867 755731004836 Double zinc ribbon; Region: DZR; pfam12773 755731004837 TM2 domain; Region: TM2; pfam05154 755731004838 MerR HTH family regulatory protein; Region: MerR_1; pfam13411 755731004839 Helix-Turn-Helix DNA binding domain of putative MlrA-like transcription regulators; Region: HTH_MlrA-like_sg1; cd04764 755731004840 DNA binding residues [nucleotide binding] 755731004841 Pseudouridylate synthases, 23S RNA-specific [Translation, ribosomal structure and biogenesis]; Region: RluA; COG0564 755731004842 Pseudouridine synthase, RsuA/RluD family; Region: PseudoU_synth_RluCD_like; cd02869 755731004843 active site 755731004844 Cystathionine beta-lyase family protein involved in aluminum resistance [Inorganic ion transport and metabolism]; Region: COG4100 755731004845 Aluminium resistance protein; Region: Alum_res; pfam06838 755731004846 HlyD family secretion protein; Region: HlyD_2; pfam12700 755731004847 putative membrane fusion protein; Region: TIGR02828 755731004848 Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzymes, YBL036c-like proteins; Region: PLPDE_III_YBL036c_like; cd00635 755731004849 pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site 755731004850 catalytic residue [active] 755731004851 Protein of unknown function (DUF552); Region: DUF552; pfam04472 755731004852 YGGT family; Region: YGGT; pfam02325 755731004853 Uncharacterized conserved protein, contains S4-like domain [Function unknown]; Region: COG2302 755731004854 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 755731004855 RNA binding surface [nucleotide binding]; other site 755731004856 DivIVA protein; Region: DivIVA; pfam05103 755731004857 DivIVA domain; Region: DivI1A_domain; TIGR03544 755731004858 DNA segregation ATPase FtsK/SpoIIIE and related proteins [Cell division and chromosome partitioning]; Region: FtsK; COG1674 755731004859 FtsK/SpoIIIE family; Region: FtsK_SpoIIIE; pfam01580 755731004860 Ftsk gamma domain; Region: Ftsk_gamma; pfam09397 755731004861 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 755731004862 binding surface 755731004863 TPR repeat; Region: TPR_11; pfam13414 755731004864 TPR motif; other site 755731004865 TPR repeat; Region: TPR_11; pfam13414 755731004866 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 755731004867 TPR motif; other site 755731004868 TPR repeat; Region: TPR_11; pfam13414 755731004869 binding surface 755731004870 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 755731004871 binding surface 755731004872 TPR motif; other site 755731004873 TPR repeat; Region: TPR_11; pfam13414 755731004874 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 755731004875 binding surface 755731004876 TPR repeat; Region: TPR_11; pfam13414 755731004877 TPR motif; other site 755731004878 Tetratricopeptide repeat; Region: TPR_12; pfam13424 755731004879 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 755731004880 binding surface 755731004881 TPR motif; other site 755731004882 Radical SAM N-terminal; Region: Radical_SAM_N; pfam08497 755731004883 hypothetical protein; Provisional; Region: PRK00955 755731004884 Domain of unknown function (DUF3362); Region: DUF3362; pfam11842 755731004885 bifunctional 5,10-methylene-tetrahydrofolate dehydrogenase/ 5,10-methylene-tetrahydrofolate cyclohydrolase; Provisional; Region: PRK14190 755731004886 Tetrahydrofolate dehydrogenase/cyclohydrolase, catalytic domain; Region: THF_DHG_CYH; pfam00763 755731004887 NADP binding domain of methylene-tetrahydrofolate dehydrogenase/cyclohydrolase; Region: NAD_bind_m-THF_DH_Cyclohyd; cd01080 755731004888 homodimer interface [polypeptide binding]; other site 755731004889 NADP binding site [chemical binding]; other site 755731004890 substrate binding site [chemical binding]; other site 755731004891 phosphodiesterase; Provisional; Region: PRK12704 755731004892 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 755731004893 Zn2+ binding site [ion binding]; other site 755731004894 Mg2+ binding site [ion binding]; other site 755731004895 Deinococcus radiodurans DR1281 and related proteins, metallophosphatase domain; Region: MPP_DR1281; cd07382 755731004896 Calcineurin-like phosphoesterase; Region: Metallophos; pfam00149 755731004897 putative active site [active] 755731004898 metal binding site [ion binding]; metal-binding site 755731004899 homodimer binding site [polypeptide binding]; other site 755731004900 Multicopper polyphenol oxidase (laccase) [Secondary metabolites biosynthesis, transport and catabolism]; Region: yfiH; COG1496 755731004901 Multi-copper polyphenol oxidoreductase laccase; Region: Cu-oxidase_4; pfam02578 755731004902 ABC-type dipeptide transport system, periplasmic component [Amino acid transport and metabolism]; Region: DdpA; COG0747 755731004903 The substrate-binding component of ABC-type thermophilic oligopeptide-binding protein Hb8-like import systems, contains the type 2 periplasmic binding fold; Region: PBP2_thermophilic_Hb8_like; cd08513 755731004904 peptide binding site [polypeptide binding]; other site 755731004905 dimer interface [polypeptide binding]; other site 755731004906 lipoprotein signal peptidase; Provisional; Region: PRK14787 755731004907 lipoprotein signal peptidase; Provisional; Region: PRK14791 755731004908 Pseudouridylate synthases, 23S RNA-specific [Translation, ribosomal structure and biogenesis]; Region: RluA; COG0564 755731004909 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 755731004910 RNA binding surface [nucleotide binding]; other site 755731004911 Pseudouridine synthase, RsuA/RluD family; Region: PseudoU_synth_RluCD_like; cd02869 755731004912 active site 755731004913 Pyrimidine operon attenuation protein/uracil phosphoribosyltransferase [Nucleotide transport and metabolism]; Region: PyrR; COG2065 755731004914 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 755731004915 active site 755731004916 aspartate carbamoyltransferase catalytic subunit; Provisional; Region: pyrB; PRK00856 755731004917 Aspartate/ornithine carbamoyltransferase, carbamoyl-P binding domain; Region: OTCace_N; pfam02729 755731004918 Aspartate/ornithine carbamoyltransferase, Asp/Orn binding domain; Region: OTCace; pfam00185 755731004919 dihydroorotase; Validated; Region: pyrC; PRK09357 755731004920 Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281 755731004921 Dihydroorotase (DHOase), subgroup IIa; DHOases catalyze the reversible interconversion of carbamoyl aspartate to dihydroorotate, a key reaction in pyrimidine biosynthesis. This subgroup also contains proteins that lack the active site, like unc-33, a C; Region: DHOase_IIa; cd01317 755731004922 active site 755731004923 Orotidine 5'-phosphate decarboxylase (ODCase) is a dimeric enzyme that decarboxylates orotidine 5'-monophosphate (OMP) to form uridine 5'-phosphate (UMP), an essential step in the pyrimidine biosynthetic pathway. In mammals, UMP synthase...; Region: OMP_decarboxylase_like; cd04725 755731004924 active site 755731004925 dimer interface [polypeptide binding]; other site 755731004926 carbamoyl phosphate synthase small subunit; Reviewed; Region: PRK12564 755731004927 Carbamoyl-phosphate synthase small chain, CPSase domain; Region: CPSase_sm_chain; pfam00988 755731004928 Small chain of the glutamine-dependent form of carbamoyl phosphate synthase, CPSase II; Region: GATase1_CPSase; cd01744 755731004929 catalytic site [active] 755731004930 subunit interface [polypeptide binding]; other site 755731004931 carbamoyl phosphate synthase large subunit; Reviewed; Region: carB; PRK05294 755731004932 Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289 755731004933 Carbamoyl-phosphate synthase L chain, ATP binding domain; Region: CPSase_L_D2; pfam02786 755731004934 Carbamoyl-phosphate synthetase large chain, oligomerisation domain; Region: CPSase_L_D3; pfam02787 755731004935 Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289 755731004936 ATP-grasp domain; Region: ATP-grasp_4; cl17255 755731004937 Methylglyoxal synthase-like domain from type II glutamine-dependent carbamoyl phosphate synthetase (CSP). CSP, a CarA and CarB heterodimer, catalyzes the production of carbamoyl phosphate which is subsequently employed in the metabolic pathways...; Region: MGS_CPS_II; cd01424 755731004938 IMP binding site; other site 755731004939 dimer interface [polypeptide binding]; other site 755731004940 interdomain contacts; other site 755731004941 partial ornithine binding site; other site 755731004942 dihydroorotate dehydrogenase electron transfer subunit; Reviewed; Region: PRK00054 755731004943 FAD/NAD binding domain in the electron transfer subunit of dihydroorotate dehydrogenase. Dihydroorotate dehydrogenases (DHODs) catalyze the only redox reaction in pyrimidine de novo biosynthesis. They catalyze the oxidation of (S)-dihydroorotate to...; Region: DHOD_e_trans; cd06218 755731004944 FAD binding pocket [chemical binding]; other site 755731004945 FAD binding motif [chemical binding]; other site 755731004946 phosphate binding motif [ion binding]; other site 755731004947 beta-alpha-beta structure motif; other site 755731004948 NAD binding pocket [chemical binding]; other site 755731004949 Iron coordination center [ion binding]; other site 755731004950 dihydroorotate dehydrogenase (subfamily 1) family protein; Region: pyrD_sub1_fam; TIGR01037 755731004951 Dihydroorotate dehydrogenase (DHOD) class 1B FMN-binding domain. DHOD catalyzes the oxidation of (S)-dihydroorotate to orotate. This is the fourth step and the only redox reaction in the de novo biosynthesis of UMP, the precursor of all pyrimidine...; Region: DHOD_1B_like; cd04740 755731004952 heterodimer interface [polypeptide binding]; other site 755731004953 active site 755731004954 FMN binding site [chemical binding]; other site 755731004955 homodimer interface [polypeptide binding]; other site 755731004956 substrate binding site [chemical binding]; other site 755731004957 Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067 755731004958 catalytic core [active] 755731004959 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 755731004960 active site 755731004961 Domain of unknown function (DUF1287); Region: DUF1287; pfam06940 755731004962 This CD includes cysteinyl-tRNA(Pro) deacylases from Haemophilus influenzae and Escherichia coli and other related bacterial proteins. These trans-acting, single-domain proteins are homologs of ProX and also the cis-acting prolyl-tRNA synthetase (ProRS)...; Region: YbaK_deacylase; cd00002 755731004963 putative deacylase active site [active] 755731004964 Uncharacterized protein related to plant photosystem II stability/assembly factor [General function prediction only]; Region: COG4447 755731004965 spore photoproduct lyase; Region: photo_TT_lyase; TIGR04070 755731004966 DNA repair photolyase [DNA replication, recombination, and repair]; Region: SplB; COG1533 755731004967 YibE/F-like protein; Region: YibE_F; pfam07907 755731004968 Protein of unknown function, DUF486; Region: DUF486; cl01236 755731004969 Type 1 periplasmic binding fold superfamily; Region: Periplasmic_Binding_Protein_Type_1; cl10011 755731004970 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 755731004971 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 755731004972 metal binding site [ion binding]; metal-binding site 755731004973 active site 755731004974 I-site; other site 755731004975 EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2). The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948 755731004976 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 755731004977 RNA polymerase sigma factor, sigma-70 family; Region: sigma70-ECF; TIGR02937 755731004978 DNA binding residues [nucleotide binding] 755731004979 MRP (Multiple Resistance and pH adaptation) is a homologue of the Fer4_NifH superfamily. Like the other members of the superfamily, MRP contains a ATP-binding domain at the N-termini. It is found in bacteria as a membrane-spanning protein and functions...; Region: MRP-like; cd02037 755731004980 ATPases involved in chromosome partitioning [Cell division and chromosome partitioning]; Region: Mrp; COG0489 755731004981 This uncharacterized conserved protein belongs to a family of iron-molybdenum cluster-binding proteins that includes NifX, NifB, and NifY, all of which are involved in the synthesis of an iron-molybdenum cofactor (FeMo-co) that binds the active site of...; Region: MTH1175; cd00851 755731004982 Predicted membrane protein [Function unknown]; Region: COG2855 755731004983 Transcriptional regulator [Transcription]; Region: LysR; COG0583 755731004984 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 755731004985 C-terminal substrate binding domain of LysR-type transcriptional regulator CysL, which activates the transcription of the cysJI operon encoding sulfite reductase, contains the type 2 periplasmic binding fold; Region: PBP2_CysL_like; cd08420 755731004986 putative dimerization interface [polypeptide binding]; other site 755731004987 4Fe-4S binding domain; Region: Fer4_5; pfam12801 755731004988 RPB11 and RPB3 subunits of RNA polymerase; Region: RNAP_RPB11_RPB3; cl11409 755731004989 4Fe-4S dicluster domain; Region: Fer4_9; pfam13187 755731004990 Putative redox-active protein (C_GCAxxG_C_C); Region: C_GCAxxG_C_C; cl09920 755731004991 Protease prsW family; Region: PrsW-protease; pfam13367 755731004992 DNA binding residues [nucleotide binding] 755731004993 helix_turn_helix, Lux Regulon; Region: HTH_LUXR; smart00421 755731004994 Uncharacterized protein conserved in bacteria (DUF2087); Region: DUF2087; pfam09860 755731004995 Domain of unknown function (DUF1905); Region: DUF1905; pfam08922 755731004996 ACT domains are commonly involved in specifically binding an amino acid or other small ligand leading to regulation of the enzyme; Region: ACT; cl09141 755731004997 Metallo-beta-lactamase superfamily; Region: Lactamase_B; smart00849 755731004998 Flavodoxin domain; Region: Flavodoxin_5; cl17428 755731004999 Threonine aldolase [Amino acid transport and metabolism]; Region: GLY1; COG2008 755731005000 Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321 755731005001 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 755731005002 catalytic residue [active] 755731005003 4-Oxalocrotonate Tautomerase: Catalyzes the isomerization of unsaturated ketones. The structure is a homohexamer that is arranged as a trimer of dimers. The hexamer contains six active sites, each formed by residues from three monomers, two from one...; Region: 4Oxalocrotonate_Tautomerase; cl00235 755731005004 active site 1 [active] 755731005005 dimer interface [polypeptide binding]; other site 755731005006 hexamer interface [polypeptide binding]; other site 755731005007 active site 2 [active] 755731005008 Carboxypeptidase regulatory-like domain; Region: CarboxypepD_reg; pfam13620 755731005009 gluconate 5-dehydrogenase; Provisional; Region: PRK08213 755731005010 gluconate 5-dehydrogenase (Ga5DH)-like, classical (c) SDRs; Region: Ga5DH-like_SDR_c; cd05347 755731005011 NADP binding site [chemical binding]; other site 755731005012 homodimer interface [polypeptide binding]; other site 755731005013 active site 755731005014 short chain dehydrogenase; Provisional; Region: PRK07326 755731005015 classical (c) SDRs; Region: SDR_c; cd05233 755731005016 NAD(P) binding site [chemical binding]; other site 755731005017 active site 755731005018 spore photoproduct lyase; Region: photo_TT_lyase; cl15393 755731005019 Phosphorylase superfamily; Region: PNP_UDP_1; cl00303 755731005020 Copper amine oxidase N-terminal domain; Region: Cu_amine_oxidN1; pfam07833 755731005021 Copper amine oxidase N-terminal domain; Region: Cu_amine_oxidN1; pfam07833 755731005022 Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain [Posttranslational modification, protein turnover, chaperones]; Region: DegQ; COG0265 755731005023 Trypsin-like peptidase domain; Region: Trypsin_2; pfam13365 755731005024 ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132 755731005025 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 755731005026 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 755731005027 Walker A/P-loop; other site 755731005028 ATP binding site [chemical binding]; other site 755731005029 Q-loop/lid; other site 755731005030 ABC transporter signature motif; other site 755731005031 Walker B; other site 755731005032 D-loop; other site 755731005033 H-loop/switch region; other site 755731005034 ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132 755731005035 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 755731005036 ATP-binding cassette domain of glucan transporter and related proteins, subfamily C; Region: ABCC_Glucan_exporter_like; cd03254 755731005037 Walker A/P-loop; other site 755731005038 ATP binding site [chemical binding]; other site 755731005039 Q-loop/lid; other site 755731005040 ABC transporter signature motif; other site 755731005041 Walker B; other site 755731005042 D-loop; other site 755731005043 H-loop/switch region; other site 755731005044 Flavodoxin-like fold; Region: Flavodoxin_2; cl00438 755731005045 Peptidase inhibitor I9; Region: Inhibitor_I9; pfam05922 755731005046 Peptidase S8 family domain, uncharacterized subfamily 1; Region: Peptidases_S8_1; cd07487 755731005047 active site 755731005048 catalytic triad [active] 755731005049 Intracellular proteinase inhibitor; Region: BsuPI; pfam12690 755731005050 The GH18 (glycosyl hydrolase, family 18) type II chitinases hydrolyze chitin, an abundant polymer of beta-1,4-linked N-acetylglucosamine (GlcNAc) which is a major component of the cell wall of fungi and the exoskeleton of arthropods. Chitinases have...; Region: GH18_chitinase-like; cl10447 755731005051 active site 755731005052 Glyco_18 domain; Region: Glyco_18; smart00636 755731005053 S-layer homology domain; Region: SLH; pfam00395 755731005054 S-layer homology domain; Region: SLH; pfam00395 755731005055 S-layer homology domain; Region: SLH; pfam00395 755731005056 Adenosylcobinamide kinase / adenosylcobinamide phosphate guanyltransferase (CobU). CobU is bifunctional cobalbumin biosynthesis enzymes which display adenosylcobinamide kinase and adenosylcobinamide phosphate guanyltransferase activity. This enzyme is a...; Region: CobU; cd00544 755731005057 homotrimer interface [polypeptide binding]; other site 755731005058 Walker A motif; other site 755731005059 GTP binding site [chemical binding]; other site 755731005060 Walker B motif; other site 755731005061 cobalamin synthase; Reviewed; Region: cobS; PRK00235 755731005062 Phosphoribosyltransferase; Region: DBI_PRT; pfam02277 755731005063 Nicotinate-nucleotide-dimethylbenzimidazole phosphoribosyltransferase (DMB-PRT), also called CobT; Region: DMB-PRT_CobT; cd02439 755731005064 putative dimer interface [polypeptide binding]; other site 755731005065 active site pocket [active] 755731005066 putative cataytic base [active] 755731005067 Domain of unknown function (DUF4177); Region: DUF4177; pfam13783 755731005068 Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all...; Region: FN3; cd00063 755731005069 Interdomain contacts; other site 755731005070 Cytokine receptor motif; other site 755731005071 Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all...; Region: FN3; cl00065 755731005072 Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all...; Region: FN3; cd00063 755731005073 Cytokine receptor motif; other site 755731005074 O-Glycosyl hydrolase [Cell envelope biogenesis, outer membrane]; Region: COG5520 755731005075 O-Glycosyl hydrolase family 30; Region: Glyco_hydro_30; pfam02055 755731005076 Dockerin type I repeat; Region: Dockerin_1; pfam00404 755731005077 Dockerin type I repeat; Region: Dockerin_1; pfam00404 755731005078 deoxyguanosinetriphosphate triphosphohydrolase-like protein; Provisional; Region: PRK01286 755731005079 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 755731005080 Zn2+ binding site [ion binding]; other site 755731005081 Mg2+ binding site [ion binding]; other site 755731005082 Phosphohydrolase-associated domain; Region: HD_assoc; pfam13286 755731005083 PAS domain S-box; Region: sensory_box; TIGR00229 755731005084 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 755731005085 putative active site [active] 755731005086 heme pocket [chemical binding]; other site 755731005087 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 755731005088 ATPases associated with a variety of cellular activities; Region: AAA; smart00382 755731005089 Walker A motif; other site 755731005090 ATP binding site [chemical binding]; other site 755731005091 Walker B motif; other site 755731005092 arginine finger; other site 755731005093 Helix-turn-helix domain of Hin and related proteins, a family of DNA-binding domains unique to bacteria and represented by the Hin protein of Salmonella. The basic HTH domain is a simple fold comprised of three core helices that form a right-handed...; Region: HTH_Hin_like; cd00569 755731005094 DNA-binding interface [nucleotide binding]; DNA binding site 755731005095 Tryptophanase [Amino acid transport and metabolism]; Region: TnaA; COG3033 755731005096 Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321 755731005097 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 755731005098 catalytic residue [active] 755731005099 Gamma-aminobutyrate permease and related permeases [Amino acid transport and metabolism]; Region: AnsP; COG1113 755731005100 YjgF, YER057c, and UK114 belong to a large family of proteins present in bacteria, archaea, and eukaryotes with no definitive function. The conserved domain is similar in structure to chorismate mutase but there is no sequence similarity and no...; Region: YjgF_YER057c_UK114_family; cd00448 755731005101 homotrimer interaction site [polypeptide binding]; other site 755731005102 putative active site [active] 755731005103 RNA polymerase factor sigma-54; Reviewed; Region: PRK05932 755731005104 Sigma-54 factor, Activator interacting domain (AID); Region: Sigma54_AID; pfam00309 755731005105 Sigma-54 factor, core binding domain; Region: Sigma54_CBD; pfam04963 755731005106 Sigma-54, DNA binding domain; Region: Sigma54_DBD; pfam04552 755731005107 Acetyltransferase (GNAT) domain; Region: Acetyltransf_3; pfam13302 755731005108 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 755731005109 Coenzyme A binding pocket [chemical binding]; other site 755731005110 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl17182 755731005111 Rad3-related DNA helicases [Transcription / DNA replication, recombination, and repair]; Region: DinG; COG1199 755731005112 DEAD/DEAH box helicase; Region: DEAD; pfam00270 755731005113 DEAD_2; Region: DEAD_2; pfam06733 755731005114 Helicase C-terminal domain; Region: Helicase_C_2; pfam13307 755731005115 Superfamily I DNA and RNA helicases [DNA replication, recombination, and repair]; Region: UvrD; COG0210 755731005116 Part of AAA domain; Region: AAA_19; pfam13245 755731005117 Family description; Region: UvrD_C_2; pfam13538 755731005118 Predicted hydrolase of the HAD superfamily [General function prediction only]; Region: COG2179 755731005119 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 755731005120 active site 755731005121 motif I; other site 755731005122 motif II; other site 755731005123 shikimate 5-dehydrogenase; Reviewed; Region: aroE; PRK00258 755731005124 Shikimate dehydrogenase substrate binding domain; Region: Shikimate_dh_N; pfam08501 755731005125 NAD(P) binding domain of Shikimate dehydrogenase; Region: NAD_bind_Shikimate_DH; cd01065 755731005126 shikimate binding site; other site 755731005127 NAD(P) binding site [chemical binding]; other site 755731005128 Late competence development protein ComFB; Region: ComFB; pfam10719 755731005129 Uncharacterized membrane-associated protein [Function unknown]; Region: DedA; COG0586 755731005130 SNARE associated Golgi protein; Region: SNARE_assoc; pfam09335 755731005131 Transcriptional regulator [Transcription]; Region: LytR; COG1316 755731005132 indolepyruvate ferredoxin oxidoreductase, alpha subunit; Region: IOR_alpha; TIGR03336 755731005133 Pyrimidine (PYR) binding domain of pyruvate ferredoxin oxidoreductase (PFOR), indolepyruvate ferredoxin oxidoreductase alpha subunit (IOR-alpha), and related proteins; Region: TPP_PYR_PFOR_IOR-alpha_like; cd07034 755731005134 dimer interface [polypeptide binding]; other site 755731005135 PYR/PP interface [polypeptide binding]; other site 755731005136 TPP binding site [chemical binding]; other site 755731005137 substrate binding site [chemical binding]; other site 755731005138 Thiamine pyrophosphate (TPP) family, IOR-alpha subfamily, TPP-binding module; composed of proteins similar to indolepyruvate ferredoxin oxidoreductase (IOR) alpha subunit. IOR catalyzes the oxidative decarboxylation of arylpyruvates, such as...; Region: TPP_IOR_alpha; cd02008 755731005139 TPP-binding site; other site 755731005140 RPB11 and RPB3 subunits of RNA polymerase; Region: RNAP_RPB11_RPB3; cl11409 755731005141 indolepyruvate oxidoreductase subunit beta; Reviewed; Region: PRK06853 755731005142 2-oxoglutarate ferredoxin oxidoreductase subunit gamma; Validated; Region: PRK08537 755731005143 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 755731005144 phenylacetate-CoA ligase; Region: PA_CoA_ligase; TIGR02155 755731005145 acyl-activating enzyme (AAE) consensus motif; other site 755731005146 AMP binding site [chemical binding]; other site 755731005147 active site 755731005148 CoA binding site [chemical binding]; other site 755731005149 ACT domain-containing protein [General function prediction only]; Region: COG4747 755731005150 N-terminal ACT domain of a novel protein composed almost entirely of two tandem ACT domains; Region: ACT_Bt0572_1; cd04908 755731005151 C-terminal ACT domain of a novel protein composed of just two ACT domains; Region: ACT_Bt0572_2; cd04882 755731005152 4'-phosphopantetheinyl transferase superfamily; Region: ACPS; pfam01648 755731005153 Predicted thioesterase involved in non-ribosomal peptide biosynthesis [Secondary metabolites biosynthesis, transport, and catabolism]; Region: GrsT; COG3208 755731005154 atypical (a) SDRs, subgroup 1; Region: SDR_a1; cd05265 755731005155 putative NAD(P) binding site [chemical binding]; other site 755731005156 Nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: WcaG; COG0451 755731005157 active site 755731005158 competence damage-inducible protein A; Provisional; Region: PRK00549 755731005159 Competence-damaged protein. CinA is the first gene in the competence- inducible (cin) operon and is thought to be specifically required at some stage in the process of transformation. This domain is closely related to a domain, found in a variety of...; Region: cinA; cd00885 755731005160 putative MPT binding site; other site 755731005161 Competence-damaged protein; Region: CinA; pfam02464 755731005162 Uncharacterized membrane protein, putative virulence factor [General function prediction only]; Region: MviN; COG0728 755731005163 MurJ/MviN, a subfamily of the multidrug and toxic compound extrusion (MATE)-like proteins; Region: MATE_MurJ_like; cd13123 755731005164 recombinase A; Provisional; Region: recA; PRK09354 755731005165 RecA is a bacterial enzyme which has roles in homologous recombination, DNA repair, and the induction of the SOS response. RecA couples ATP hydrolysis to DNA strand exchange; Region: recA; cd00983 755731005166 hexamer interface [polypeptide binding]; other site 755731005167 Walker A motif; other site 755731005168 ATP binding site [chemical binding]; other site 755731005169 Walker B motif; other site 755731005170 recombination regulator RecX; Reviewed; Region: recX; PRK00117 755731005171 2-methylthioadenine synthetase [Translation, ribosomal structure and biogenesis]; Region: MiaB; COG0621 755731005172 Uncharacterized protein family UPF0004; Region: UPF0004; pfam00919 755731005173 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 755731005174 FeS/SAM binding site; other site 755731005175 CDP-diacylglycerol--glycerol-3-phosphate 3-phosphatidyltransferase; Region: pgsA; TIGR00560 755731005176 fatty acid biosynthesis transcriptional regulator; Provisional; Region: PRK04424 755731005177 DeoR-like helix-turn-helix domain; Region: HTH_DeoR; cl17531 755731005178 The hotdog fold was initially identified in the E. coli FabA (beta-hydroxydecanoyl-acyl carrier protein (ACP)-dehydratase) structure and subsequently in 4HBT (4-hydroxybenzoyl-CoA thioesterase) from Pseudomonas. A number of other seemingly unrelated...; Region: hot_dog; cd03440 755731005179 active site 2 [active] 755731005180 active site 1 [active] 755731005181 putative phosphate acyltransferase; Provisional; Region: PRK05331 755731005182 3-oxoacyl-(acyl carrier protein) synthase III; Reviewed; Region: PRK09352 755731005183 Ketoacyl-acyl carrier protein synthase III (KASIII) initiates the elongation in type II fatty acid synthase systems. It is found in bacteria and plants. Elongation of fatty acids in the type II systems occurs by Claisen condensation of malonyl-acyl...; Region: KAS_III; cd00830 755731005184 dimer interface [polypeptide binding]; other site 755731005185 active site 755731005186 CoA binding pocket [chemical binding]; other site 755731005187 (acyl-carrier-protein) S-malonyltransferase [Lipid metabolism]; Region: FabD; COG0331 755731005188 malonyl CoA-acyl carrier protein transacylase; Region: fabD; TIGR00128 755731005189 3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05557 755731005190 beta-Keto acyl carrier protein reductase (BKR), involved in Type II FAS, classical (c) SDRs; Region: BKR_SDR_c; cd05333 755731005191 NAD(P) binding site [chemical binding]; other site 755731005192 homotetramer interface [polypeptide binding]; other site 755731005193 homodimer interface [polypeptide binding]; other site 755731005194 active site 755731005195 acyl carrier protein; Provisional; Region: acpP; PRK00982 755731005196 beta-ketoacyl-acyl-carrier-protein synthase II; Region: fabF; TIGR03150 755731005197 Beta-ketoacyl-acyl carrier protein (ACP) synthase (KAS), type I and II. KASs are responsible for the elongation steps in fatty acid biosynthesis. KASIII catalyses the initial condensation and KAS I and II catalyze further elongation steps by Claisen...; Region: KAS_I_II; cd00834 755731005198 dimer interface [polypeptide binding]; other site 755731005199 active site 755731005200 ribonuclease III; Reviewed; Region: rnc; PRK00102 755731005201 RIBOc. Ribonuclease III C terminal domain. This group consists of eukaryotic, bacterial and archeal ribonuclease III (RNAse III) proteins. RNAse III is a double stranded RNA-specific endonuclease. Prokaryotic RNAse III is important in...; Region: RIBOc; cd00593 755731005202 dimerization interface [polypeptide binding]; other site 755731005203 active site 755731005204 metal binding site [ion binding]; metal-binding site 755731005205 Double-stranded RNA binding motif. Binding is not sequence specific but is highly specific for double stranded RNA. Found in a variety of proteins including dsRNA dependent protein kinase PKR, RNA helicases, Drosophila staufen protein, E. coli RNase III; Region: DSRM; cd00048 755731005206 dsRNA binding site [nucleotide binding]; other site 755731005207 Elongator protein 3, MiaB family, Radical SAM; Region: Elp3; smart00729 755731005208 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 755731005209 FeS/SAM binding site; other site 755731005210 Stage V sporulation protein S (SpoVS); Region: SpoVS; pfam04232 755731005211 Superoxide dismutase [Inorganic ion transport and metabolism]; Region: SodA; COG0605 755731005212 Iron/manganese superoxide dismutases, alpha-hairpin domain; Region: Sod_Fe_N; pfam00081 755731005213 Iron/manganese superoxide dismutases, C-terminal domain; Region: Sod_Fe_C; pfam02777 755731005214 Coat F domain; Region: Coat_F; pfam07875 755731005215 Proteins of this family catalyze the reduction of flavin or nitrocompounds using NAD(P)H as electron donor in a obligatory two-electron transfer, utilizing FMN or FAD as cofactor. They are often found to be homodimers. Enzymes of this family are...; Region: Nitro_FMN_reductase; cl00514 755731005216 FMN binding site [chemical binding]; other site 755731005217 dimer interface [polypeptide binding]; other site 755731005218 Proteins of this family catalyze the reduction of flavin or nitrocompounds using NAD(P)H as electron donor in a obligatory two-electron transfer, utilizing FMN or FAD as cofactor. They are often found to be homodimers. Enzymes of this family are...; Region: Nitro_FMN_reductase; cl00514 755731005219 dimer interface [polypeptide binding]; other site 755731005220 Predicted oxidoreductases of the aldo/keto reductase family [General function prediction only]; Region: COG1453 755731005221 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 755731005222 active site 755731005223 catalytic tetrad [active] 755731005224 The HCP family of iron-sulfur proteins includes hybrid cluster protein (HCP), acetyl-CoA synthase (ACS), and carbon monoxide dehydrogenase (CODH), all of which contain [Fe4-S4] metal clusters at their active sites. These proteins have a conserved...; Region: HCP_like; cl14655 755731005225 chromosome segregation protein SMC, common bacterial type; Region: SMC_prok_B; TIGR02168 755731005226 ATP-binding cassette domain of barmotin, a member of the SMC protein family; Region: ABC_SMC_barmotin; cd03278 755731005227 Walker A/P-loop; other site 755731005228 ATP binding site [chemical binding]; other site 755731005229 Q-loop/lid; other site 755731005230 SMC proteins Flexible Hinge Domain; Region: SMC_hinge; smart00968 755731005231 ATP-binding cassette domain of barmotin, a member of the SMC protein family; Region: ABC_SMC_barmotin; cd03278 755731005232 Q-loop/lid; other site 755731005233 ABC transporter signature motif; other site 755731005234 Walker B; other site 755731005235 D-loop; other site 755731005236 H-loop/switch region; other site 755731005237 signal recognition particle-docking protein FtsY; Provisional; Region: PRK10416 755731005238 SRP54-type protein, helical bundle domain; Region: SRP54_N; pfam02881 755731005239 The signal recognition particle (SRP) mediates the transport to or across the plasma membrane in bacteria and the endoplasmic reticulum in eukaryotes. SRP recognizes N-terminal sighnal sequences of newly synthesized polypeptides at the ribosome. The...; Region: SRP; cd03115 755731005240 GTP binding site [chemical binding]; other site 755731005241 Uncharacterized protein family (UPF0182); Region: UPF0182; pfam03699 755731005242 Uncharacterized conserved protein [Function unknown]; Region: COG1615 755731005243 Amino acid permease; Region: AA_permease_2; pfam13520 755731005244 K+ potassium transporter; Region: K_trans; cl15781 755731005245 Transcriptional regulator/sugar kinase [Transcription / Carbohydrate transport and metabolism]; Region: NagC; COG1940 755731005246 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cd00012 755731005247 nucleotide binding site [chemical binding]; other site 755731005248 Uncharacterized protein conserved in bacteria (DUF2128); Region: DUF2128; pfam09901 755731005249 anaerobic ribonucleoside triphosphate reductase; Provisional; Region: PRK07111 755731005250 ATP cone domain; Region: ATP-cone; pfam03477 755731005251 Ribonucleotide reductase and Pyruvate formate lyase; Region: RNR_PFL; cl09939 755731005252 Class III ribonucleotide reductase; Region: RNR_III; cd01675 755731005253 active site 755731005254 Zn binding site [ion binding]; other site 755731005255 glycine loop; other site 755731005256 anaerobic ribonucleoside-triphosphate reductase activating protein; Region: NrdG; TIGR02491 755731005257 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 755731005258 FeS/SAM binding site; other site 755731005259 Sulfatase; Region: Sulfatase; cl17466 755731005260 pantothenate kinase; Provisional; Region: PRK13317 755731005261 pantothenate kinase, eukaryotic/staphyloccocal type; Region: panK_eukar; TIGR00555 755731005262 OPT oligopeptide transporter protein; Region: OPT; cl14607 755731005263 putative oligopeptide transporter, OPT family; Region: TIGR00733 755731005264 Uncharacterized subfamily of N-terminal LabA-like domains; Region: LabA_like_N_1; cd11297 755731005265 putative metal binding site [ion binding]; other site 755731005266 Uncharacterized conserved protein [Function unknown]; Region: COG1432 755731005267 C-terminal domain of LabA_like proteins; Region: LabA_like_C; cd10146 755731005268 Putative helix-turn-helix protein, YlxM / p13 like; Region: UPF0122; pfam04297 755731005269 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 755731005270 DNA binding residues [nucleotide binding] 755731005271 signal recognition particle protein; Provisional; Region: PRK10867 755731005272 SRP54-type protein, helical bundle domain; Region: SRP54_N; smart00963 755731005273 The signal recognition particle (SRP) mediates the transport to or across the plasma membrane in bacteria and the endoplasmic reticulum in eukaryotes. SRP recognizes N-terminal sighnal sequences of newly synthesized polypeptides at the ribosome. The...; Region: SRP; cd03115 755731005274 P loop; other site 755731005275 GTP binding site [chemical binding]; other site 755731005276 Signal peptide binding domain; Region: SRP_SPB; pfam02978 755731005277 30S ribosomal protein S16; Reviewed; Region: rpsP; PRK00040 755731005278 Predicted RNA-binding protein (contains KH domain) [General function prediction only]; Region: COG1837 755731005279 hypothetical protein; Provisional; Region: PRK00468 755731005280 16S rRNA-processing protein RimM; Provisional; Region: rimM; PRK00122 755731005281 RimM N-terminal domain; Region: RimM; pfam01782 755731005282 PRC-barrel domain; Region: PRC; pfam05239 755731005283 tRNA (guanine-N(1)-)-methyltransferase; Reviewed; Region: trmD; PRK00026 755731005284 Uncharacterized small protein (DUF2292); Region: DUF2292; pfam10055 755731005285 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 755731005286 Radical SAM superfamily; Region: Radical_SAM; pfam04055 755731005287 FeS/SAM binding site; other site 755731005288 This CD represents a family of iron-molybdenum cluster-binding proteins that includes NifB, NifX, and NifY, all of which are involved in the synthesis of an iron-molybdenum cofactor (FeMo-co) that binds the active site of the dinitrogenase enzyme. This...; Region: NifX_NifB; cl00252 755731005289 NifH gene encodes component II (iron protein) of nitrogenase. Nitrogenase is responsible for the biological nitrogen fixation, i.e. reduction of molecular nitrogen to ammonia. NifH consists of two oxygen-sensitive metallosulfur proteins: the...; Region: NifH; cd02040 755731005290 nitrogenase iron protein; Region: nifH; TIGR01287 755731005291 Nucleotide-binding sites [chemical binding]; other site 755731005292 Walker A motif; other site 755731005293 Switch I region of nucleotide binding site; other site 755731005294 Fe4S4 binding sites [ion binding]; other site 755731005295 Switch II region of nucleotide binding site; other site 755731005296 The nitrogenase enzyme system catalyzes the ATP-dependent reduction of dinitrogen to ammonia. This group contains both alpha and beta subunits of component 1 of the three known genetically distinct types of nitrogenase systems: a molybdenum-dependent; Region: Oxidoreductase_nitrogenase; cl02775 755731005297 Nitrogenase component 1 type Oxidoreductase; Region: Oxidored_nitro; pfam00148 755731005298 Nitrogenase_vnfN_like: VnfN subunit of the VnfEN complex-like. This group in addition to VnfN contains a subset of the beta subunit of the nitrogenase MoFe protein and NifN-like proteins. The nitrogenase enzyme system catalyzes the ATP-dependent...; Region: Nitrogenase_VnfN_like; cd01971 755731005299 Nitrogenase component 1 type Oxidoreductase; Region: Oxidored_nitro; pfam00148 755731005300 Cys/Met metabolism PLP-dependent enzyme; Region: Cys_Met_Meta_PP; pfam01053 755731005301 CGS_like: Cystathionine gamma-synthase is a PLP dependent enzyme and catalyzes the committed step of methionine biosynthesis. This pathway is unique to microorganisms and plants, rendering the enzyme an attractive target for the development of...; Region: CGS_like; cd00614 755731005302 homodimer interface [polypeptide binding]; other site 755731005303 substrate-cofactor binding pocket; other site 755731005304 pyridoxal 5'-phosphate binding site [chemical binding]; other site 755731005305 catalytic residue [active] 755731005306 Cysteine synthase [Amino acid transport and metabolism]; Region: CysK; COG0031 755731005307 CBS_like: This subgroup includes Cystathionine beta-synthase (CBS) and Cysteine synthase. CBS is a unique heme-containing enzyme that catalyzes a pyridoxal 5'-phosphate (PLP)-dependent condensation of serine and homocysteine to give cystathionine; Region: CBS_like; cd01561 755731005308 dimer interface [polypeptide binding]; other site 755731005309 pyridoxal 5'-phosphate binding site [chemical binding]; other site 755731005310 catalytic residue [active] 755731005311 GTPase RsgA; Reviewed; Region: PRK01889 755731005312 S1_like: Ribosomal protein S1-like RNA-binding domain. Found in a wide variety of RNA-associated proteins. Originally identified in S1 ribosomal protein. This superfamily also contains the Cold Shock Domain (CSD), which is a homolog of the S1 domain; Region: S1_like; cl09927 755731005313 RNA binding site [nucleotide binding]; other site 755731005314 Ribosomal interacting GTPase YjeQ/EngC, a circularly permuted subfamily of the Ras GTPases; Region: YjeQ_EngC; cd01854 755731005315 GTPase/Zn-binding domain interface [polypeptide binding]; other site 755731005316 GTP/Mg2+ binding site [chemical binding]; other site 755731005317 G4 box; other site 755731005318 G5 box; other site 755731005319 G1 box; other site 755731005320 Switch I region; other site 755731005321 G2 box; other site 755731005322 G3 box; other site 755731005323 Switch II region; other site 755731005324 50S ribosomal protein L19; Provisional; Region: rplS; PRK05338 755731005325 signal peptidase I, bacterial type; Region: sigpep_I_bact; TIGR02227 755731005326 The S26 Type I signal peptidase (SPase; LepB; leader peptidase B; leader peptidase I; EC 3.4.21.89) family members are essential membrane-bound serine proteases that function to cleave the amino-terminal signal peptide extension from proteins that are...; Region: S26_SPase_I; cd06530 755731005327 Catalytic site [active] 755731005328 GTPase YlqF; Reviewed; Region: rbgA; PRK09563 755731005329 Circularly permuted YlqF GTPase; Region: YlqF; cd01856 755731005330 GTP/Mg2+ binding site [chemical binding]; other site 755731005331 G4 box; other site 755731005332 G5 box; other site 755731005333 G1 box; other site 755731005334 Switch I region; other site 755731005335 G2 box; other site 755731005336 G3 box; other site 755731005337 Switch II region; other site 755731005338 bacterial Ribonuclease HII-like; Region: RNase_HII_bacteria_HII_like; cd07182 755731005339 RNA/DNA hybrid binding site [nucleotide binding]; other site 755731005340 active site 755731005341 Predicted ATPase [General function prediction only]; Region: COG5293 755731005342 Uncharacterized homolog of the cytoplasmic domain of flagellar protein FhlB [Function unknown]; Region: COG2257 755731005343 hypothetical protein; Reviewed; Region: PRK12497 755731005344 Zn-dependent dipeptidase, microsomal dipeptidase homolog [Amino acid transport and metabolism]; Region: COG2355 755731005345 renal dipeptidase (rDP), best studied in mammals and also called membrane or microsomal dipeptidase, is a membrane-bound glycoprotein hydrolyzing dipeptides and is involved in hydrolytic metabolism of penem and carbapenem beta-lactam antibiotics; Region: rDP_like; cd01301 755731005346 active site 755731005347 dimer interface [polypeptide binding]; other site 755731005348 Alanine-glyoxylate amino-transferase; Region: Aminotran_MocR; pfam12897 755731005349 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 755731005350 pyridoxal 5'-phosphate binding site [chemical binding]; other site 755731005351 homodimer interface [polypeptide binding]; other site 755731005352 catalytic residue [active] 755731005353 Adenylosuccinate lyase [Nucleotide transport and metabolism]; Region: PurB; COG0015 755731005354 Adenylsuccinate lyase (ASL)_subgroup 2; Region: Adenylsuccinate_lyase_2; cd03302 755731005355 tetramer interface [polypeptide binding]; other site 755731005356 active site 755731005357 Transcriptional regulators [Transcription]; Region: PhnF; COG2188 755731005358 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 755731005359 DNA-binding site [nucleotide binding]; DNA binding site 755731005360 UTRA domain; Region: UTRA; pfam07702 755731005361 Beta-lactamase enzyme family; Region: Beta-lactamase2; pfam13354 755731005362 Uncharacterized membrane-associated protein [Function unknown]; Region: DedA; COG0586 755731005363 SNARE associated Golgi protein; Region: SNARE_assoc; pfam09335 755731005364 Domain of Unknown Function (DUF1540); Region: DUF1540; pfam07561 755731005365 Gamma-aminobutyrate permease and related permeases [Amino acid transport and metabolism]; Region: AnsP; COG1113 755731005366 Spore germination protein; Region: Spore_permease; cl17796 755731005367 Cellulose binding domain; Region: CBM_3; pfam00942 755731005368 Carbohydrate binding domain X2; Region: CBM_X2; pfam03442 755731005369 Type I cohesin domain, interaction partner of dockerin; Region: Type_I_cohesin_like; cd08548 755731005370 dockerin binding interface; other site 755731005371 Type I cohesin domain, interaction partner of dockerin; Region: Type_I_cohesin_like; cd08548 755731005372 dockerin binding interface; other site 755731005373 Type I cohesin domain, interaction partner of dockerin; Region: Type_I_cohesin_like; cd08548 755731005374 dockerin binding interface; other site 755731005375 Type I cohesin domain, interaction partner of dockerin; Region: Type_I_cohesin_like; cd08548 755731005376 dockerin binding interface; other site 755731005377 Carbohydrate binding domain X2; Region: CBM_X2; pfam03442 755731005378 Type I cohesin domain, interaction partner of dockerin; Region: Type_I_cohesin_like; cd08548 755731005379 dockerin binding interface; other site 755731005380 Carbohydrate binding domain X2; Region: CBM_X2; pfam03442 755731005381 Type I cohesin domain, interaction partner of dockerin; Region: Type_I_cohesin_like; cd08548 755731005382 dockerin binding interface; other site 755731005383 Glycosyl hydrolase family 48; Region: Glyco_hydro_48; pfam02011 755731005384 Dockerin type I repeat; Region: Dockerin_1; pfam00404 755731005385 Glycosyl hydrolases family 8; Region: Glyco_hydro_8; cl01351 755731005386 endoglucanase; Region: PLN02308 755731005387 Glycosyl hydrolase family 9; Region: Glyco_hydro_9; pfam00759 755731005388 Cellulose binding domain; Region: CBM_3; pfam00942 755731005389 Carbohydrate binding domain; Region: CBM_4_9; pfam02018 755731005390 N-terminal Early set domain associated with the catalytic domain of cellulase; Region: E_set_Cellulase_N; cd02850 755731005391 Glycosyl hydrolase family 9; Region: Glyco_hydro_9; pfam00759 755731005392 Dockerin type I repeat; Region: Dockerin_1; pfam00404 755731005393 Type I cohesin domain, interaction partner of dockerin; Region: Type_I_cohesin_like; cd08548 755731005394 dockerin binding interface; other site 755731005395 endoglucanase; Region: PLN02420 755731005396 Glycosyl hydrolase family 9; Region: Glyco_hydro_9; pfam00759 755731005397 Cellulose binding domain; Region: CBM_3; cl03026 755731005398 Dockerin type I repeat; Region: Dockerin_1; pfam00404 755731005399 endoglucanase; Region: PLN02420 755731005400 Glycosyl hydrolase family 9; Region: Glyco_hydro_9; pfam00759 755731005401 Cellulose binding domain; Region: CBM_3; smart01067 755731005402 Dockerin type I repeat; Region: Dockerin_1; pfam00404 755731005403 Dockerin type I repeat; Region: Dockerin_1; pfam00404 755731005404 Dockerin type I repeat; Region: Dockerin_1; pfam00404 755731005405 Sugar-binding cellulase-like; Region: Cellulase-like; pfam12876 755731005406 endoglucanase; Region: PLN02420 755731005407 Glycosyl hydrolase family 9; Region: Glyco_hydro_9; pfam00759 755731005408 Dockerin type I repeat; Region: Dockerin_1; pfam00404 755731005409 Dockerin type I repeat; Region: Dockerin_1; pfam00404 755731005410 Cellulase (glycosyl hydrolase family 5); Region: Cellulase; pfam00150 755731005411 Dockerin type I repeat; Region: Dockerin_1; pfam00404 755731005412 Dockerin type I repeat; Region: Dockerin_1; pfam00404 755731005413 Cellulase (glycosyl hydrolase family 5); Region: Cellulase; pfam00150 755731005414 Endoglucanase [Carbohydrate transport and metabolism]; Region: BglC; COG2730 755731005415 Dockerin type I repeat; Region: Dockerin_1; pfam00404 755731005416 Domain of unknown function (DUF303); Region: DUF303; pfam03629 755731005417 Dockerin type I repeat; Region: Dockerin_1; pfam00404 755731005418 Transcriptional regulator [Transcription]; Region: LysR; COG0583 755731005419 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 755731005420 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cd05466 755731005421 dimerization interface [polypeptide binding]; other site 755731005422 SGNH_hydrolase, or GDSL_hydrolase, is a diverse family of lipases and esterases. The tertiary fold of the enzyme is substantially different from that of the alpha/beta hydrolase family and unique among all known hydrolases; its active site closely...; Region: SGNH_hydrolase; cd00229 755731005423 active site 755731005424 catalytic triad [active] 755731005425 oxyanion hole [active] 755731005426 N-acetylmuramoyl-L-alanine amidase [Cell envelope biogenesis, outer membrane]; Region: AmiC; COG0860 755731005427 N-acetylmuramoyl-L-alanine amidase or MurNAc-LAA (also known as peptidoglycan aminohydrolase, NAMLA amidase, NAMLAA, Amidase 3, and peptidoglycan amidase; EC 3.5.1.28) is an autolysin that hydrolyzes the amide bond between N-acetylmuramoyl and L-amino...; Region: MurNAc-LAA; cd02696 755731005428 active site 755731005429 metal binding site [ion binding]; metal-binding site 755731005430 Bacillus subtilis YvnB and related proteins, metallophosphatase domain; Region: MPP_YvnB; cd07399 755731005431 putative active site [active] 755731005432 putative metal binding site [ion binding]; other site 755731005433 Calcineurin-like phosphoesterase; Region: Metallophos; pfam00149 755731005434 Heavy-metal-associated domain (HMA) is a conserved domain of approximately 30 amino acid residues found in a number of proteins that transport or detoxify heavy metals, for example, the CPx-type heavy metal ATPases and copper chaperones. HMA domain...; Region: HMA; cd00371 755731005435 metal-binding site [ion binding] 755731005436 Family description; Region: DsbD_2; pfam13386 755731005437 Cytochrome c biogenesis protein [Posttranslational modification, protein turnover, chaperones]; Region: CcdA; COG0785 755731005438 Plastocyanin domain containing protein [General function prediction only]; Region: COG4633 755731005439 Cupredoxin-like domain; Region: Cupredoxin_1; cl17234 755731005440 Cupredoxin-like domain; Region: Cupredoxin_1; cl17234 755731005441 Cation transport ATPase [Inorganic ion transport and metabolism]; Region: ZntA; COG2217 755731005442 Heavy-metal-associated domain (HMA) is a conserved domain of approximately 30 amino acid residues found in a number of proteins that transport or detoxify heavy metals, for example, the CPx-type heavy metal ATPases and copper chaperones. HMA domain...; Region: HMA; cd00371 755731005443 metal-binding site [ion binding] 755731005444 Cation transport ATPase [Inorganic ion transport and metabolism]; Region: ZntA; COG2217 755731005445 Heavy-metal-associated domain (HMA) is a conserved domain of approximately 30 amino acid residues found in a number of proteins that transport or detoxify heavy metals, for example, the CPx-type heavy metal ATPases and copper chaperones. HMA domain...; Region: HMA; cd00371 755731005446 metal-binding site [ion binding] 755731005447 E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122 755731005448 Soluble P-type ATPase [General function prediction only]; Region: COG4087 755731005449 Bacterial SH3 domain; Region: SH3_3; pfam08239 755731005450 Bacterial SH3 domain; Region: SH3_3; pfam08239 755731005451 Cell wall-associated hydrolases (invasion-associated proteins) [Cell envelope biogenesis, outer membrane]; Region: Spr; COG0791 755731005452 NlpC/P60 family; Region: NLPC_P60; pfam00877 755731005453 The URO-D _like protein superfamily includes bacterial and eukaryotic uroporphyrinogen decarboxylases (URO-D), coenzyme M methyltransferases and other putative bacterial methyltransferases. Uroporphyrinogen decarboxylase (URO-D) decarboxylates the four...; Region: URO-D_like; cd03465 755731005454 Predicted hydrolase (HAD superfamily) [General function prediction only]; Region: COG1011 755731005455 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 755731005456 ABC-type dipeptide transport system, periplasmic component [Amino acid transport and metabolism]; Region: DdpA; COG0747 755731005457 The substrate-binding domain of an ABC-type nickel/oligopeptide-like import system contains the type 2 periplasmic binding fold; Region: PBP2_NikA_DppA_OppA_like; cl01709 755731005458 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppB; COG0601 755731005459 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 755731005460 dimer interface [polypeptide binding]; other site 755731005461 conserved gate region; other site 755731005462 putative PBP binding loops; other site 755731005463 ABC-ATPase subunit interface; other site 755731005464 nickel ABC transporter, permease subunit NikC; Region: nickel_nikC; TIGR02790 755731005465 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 755731005466 dimer interface [polypeptide binding]; other site 755731005467 conserved gate region; other site 755731005468 putative PBP binding loops; other site 755731005469 ABC-ATPase subunit interface; other site 755731005470 ABC-type dipeptide/oligopeptide/nickel transport system, ATPase component [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppD; COG0444 755731005471 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 755731005472 Walker A/P-loop; other site 755731005473 ATP binding site [chemical binding]; other site 755731005474 Q-loop/lid; other site 755731005475 ABC transporter signature motif; other site 755731005476 Walker B; other site 755731005477 D-loop; other site 755731005478 H-loop/switch region; other site 755731005479 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097 755731005480 ABC-type dipeptide/oligopeptide/nickel transport system, ATPase component [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppD; COG0444 755731005481 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 755731005482 Walker A/P-loop; other site 755731005483 ATP binding site [chemical binding]; other site 755731005484 Q-loop/lid; other site 755731005485 ABC transporter signature motif; other site 755731005486 Walker B; other site 755731005487 D-loop; other site 755731005488 H-loop/switch region; other site 755731005489 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097 755731005490 Lysophospholipase [Lipid metabolism]; Region: PldB; COG2267 755731005491 Putative lysophospholipase; Region: Hydrolase_4; pfam12146 755731005492 hybrid cluster protein; Provisional; Region: PRK05290 755731005493 The HCP family of iron-sulfur proteins includes hybrid cluster protein (HCP), acetyl-CoA synthase (ACS), and carbon monoxide dehydrogenase (CODH), all of which contain [Fe4-S4] metal clusters at their active sites. These proteins have a conserved...; Region: HCP_like; cl14655 755731005494 ACS interaction site; other site 755731005495 The HCP family of iron-sulfur proteins includes hybrid cluster protein (HCP), acetyl-CoA synthase (ACS), and carbon monoxide dehydrogenase (CODH), all of which contain [Fe4-S4] metal clusters at their active sites. These proteins have a conserved...; Region: HCP_like; cl14655 755731005496 ACS interaction site; other site 755731005497 CODH interaction site; other site 755731005498 metal cluster binding site [ion binding]; other site 755731005499 Glycosyl hydrolases family 11; Region: Glyco_hydro_11; pfam00457 755731005500 Dockerin type I repeat; Region: Dockerin_1; pfam00404 755731005501 Dockerin type I repeat; Region: Dockerin_1; pfam00404 755731005502 PPIC-type PPIASE domain; Region: Rotamase; pfam00639 755731005503 Carbohydrate Binding Module 6 (CBM6); appended to several carbohydrate binding enzymes, including several glycoside hydrolase (GH) family 26 mannanase domains; Region: CBM6_mannanase-like; cd04086 755731005504 putative metal binding site [ion binding]; other site 755731005505 Glycosyl hydrolase family 26; Region: Glyco_hydro_26; pfam02156 755731005506 endoglucanase; Region: PLN02420 755731005507 Glycosyl hydrolase family 9; Region: Glyco_hydro_9; cl02959 755731005508 N-terminal Early set domain associated with the catalytic domain of cellulase; Region: E_set_Cellulase_N; cd02850 755731005509 Glycosyl hydrolase family 9; Region: Glyco_hydro_9; cl02959 755731005510 Dockerin type I repeat; Region: Dockerin_1; pfam00404 755731005511 Dockerin type I repeat; Region: Dockerin_1; pfam00404 755731005512 N-terminal Early set domain associated with the catalytic domain of cellulase; Region: E_set_Cellulase_N; cd02850 755731005513 Glycosyl hydrolase family 9; Region: Glyco_hydro_9; cl02959 755731005514 Protein of unknown function (DUF1657); Region: DUF1657; pfam07870 755731005515 Uncharacterized BCR, YitT family COG1284; Region: DUF161; pfam02588 755731005516 Uncharacterized conserved protein [Function unknown]; Region: COG1284 755731005517 Uncharacterized BCR, YitT family COG1284; Region: DUF161; pfam02588 755731005518 Uncharacterized protein conserved in bacteria (DUF2179); Region: DUF2179; pfam10035 755731005519 Patatins and Phospholipases; Region: Patatin_and_cPLA2; cl11396 755731005520 active site 755731005521 nucleophile elbow; other site 755731005522 single-stranded DNA-binding protein; Provisional; Region: PRK05813 755731005523 SSB_OBF: A subfamily of OB folds similar to the OB fold of ssDNA-binding protein (SSB). SSBs bind with high affinity to ssDNA. They bind to and protect ssDNA intermediates during DNA metabolic pathways. All bacterial and eukaryotic SSBs studied to date...; Region: SSB_OBF; cd04496 755731005524 dimer interface [polypeptide binding]; other site 755731005525 ssDNA binding site [nucleotide binding]; other site 755731005526 tetramer (dimer of dimers) interface [polypeptide binding]; other site 755731005527 NADH dehydrogenase, FAD-containing subunit [Energy production and conversion]; Region: Ndh; COG1252 755731005528 Membrane-associated lipoprotein involved in thiamine biosynthesis [Coenzyme metabolism]; Region: ApbE; COG1477 755731005529 ApbE family; Region: ApbE; pfam02424 755731005530 N-Utilization Substance G (NusG) N terminal (NGN) insert and Lin0431 are part of DUF1312; Region: DUF1312; cd09846 755731005531 Heptaprenyl diphosphate synthase component I; Region: Hpre_diP_synt_I; pfam07456 755731005532 Geranylgeranyl pyrophosphate synthase [Coenzyme metabolism]; Region: IspA; COG0142 755731005533 Trans-Isoprenyl Diphosphate Synthases, head-to-tail; Region: Trans_IPPS_HT; cd00685 755731005534 substrate binding pocket [chemical binding]; other site 755731005535 chain length determination region; other site 755731005536 substrate-Mg2+ binding site; other site 755731005537 catalytic residues [active] 755731005538 aspartate-rich region 1; other site 755731005539 active site lid residues [active] 755731005540 aspartate-rich region 2; other site 755731005541 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 755731005542 primosomal protein N' Region: priA; TIGR00595 755731005543 ATP binding site [chemical binding]; other site 755731005544 putative Mg++ binding site [ion binding]; other site 755731005545 nucleotide binding region [chemical binding]; other site 755731005546 helicase superfamily c-terminal domain; Region: HELICc; smart00490 755731005547 ATP-binding site [chemical binding]; other site 755731005548 Polypeptide or peptide deformylase; a family of metalloenzymes that catalyzes the removal of the N-terminal formyl group in a growing polypeptide chain following translation initiation during protein synthesis in prokaryotes. These enzymes utilize Fe(II)...; Region: Pep_deformylase; cd00487 755731005549 active site 755731005550 catalytic residues [active] 755731005551 metal binding site [ion binding]; metal-binding site 755731005552 methionyl-tRNA formyltransferase; Reviewed; Region: fmt; PRK00005 755731005553 Methionyl-tRNA formyltransferase, N-terminal hydrolase domain; Region: FMT_core_Met-tRNA-FMT_N; cd08646 755731005554 putative active site [active] 755731005555 substrate binding site [chemical binding]; other site 755731005556 putative cosubstrate binding site; other site 755731005557 catalytic site [active] 755731005558 C-terminal domain of Formyltransferase and other enzymes; Region: Met_tRNA_FMT_C; cd08704 755731005559 substrate binding site [chemical binding]; other site 755731005560 Protein of unknown function DUF116; Region: DUF116; pfam01976 755731005561 Putative neutral zinc metallopeptidase; Region: Zn_peptidase_2; pfam04298 755731005562 16S rRNA methyltransferase B; Provisional; Region: PRK14902 755731005563 NusB family; Region: NusB; pfam01029 755731005564 putative RNA binding site [nucleotide binding]; other site 755731005565 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 755731005566 S-adenosylmethionine binding site [chemical binding]; other site 755731005567 ribosomal RNA large subunit methyltransferase N; Provisional; Region: PRK14454 755731005568 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 755731005569 FeS/SAM binding site; other site 755731005570 Serine/threonine phosphatases, family 2C, catalytic domain; The protein architecture and deduced catalytic mechanism of PP2C phosphatases are similar to the PP1, PP2A, PP2B family of protein Ser/Thr phosphatases, with which PP2C shares no sequence...; Region: PP2Cc; cd00143 755731005571 Protein phosphatase 2C; Region: PP2C; pfam00481 755731005572 active site 755731005573 Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220 755731005574 Catalytic domain of Protein Kinases; Region: PKc; cd00180 755731005575 active site 755731005576 ATP binding site [chemical binding]; other site 755731005577 substrate binding site [chemical binding]; other site 755731005578 activation loop (A-loop); other site 755731005579 PASTA domain of bacterial serine/threonine kinase pknB-like proteins. PknB is a member of a group of related transmembrane sensor kinases present in many gram positive bacteria, which has been shown to regulate cell shape in Mycobacterium tubercolosis; Region: PASTA_pknB; cd06577 755731005580 PASTA domain of bacterial serine/threonine kinase pknB-like proteins. PknB is a member of a group of related transmembrane sensor kinases present in many gram positive bacteria, which has been shown to regulate cell shape in Mycobacterium tubercolosis; Region: PASTA_pknB; cd06577 755731005581 PASTA domain of bacterial serine/threonine kinase pknB-like proteins. PknB is a member of a group of related transmembrane sensor kinases present in many gram positive bacteria, which has been shown to regulate cell shape in Mycobacterium tubercolosis; Region: PASTA_pknB; cd06577 755731005582 GTPase RsgA; Reviewed; Region: PRK00098 755731005583 S1_YloQ_GTPase: YloQ GTase family (also known as YjeQ and CpgA), S1-like RNA-binding domain. Proteins in the YloQ GTase family bind the ribosome and have GTPase activity. The precise role of this family is unknown. The protein structure is composed of...; Region: S1_YloQ_GTPase; cd04466 755731005584 RNA binding site [nucleotide binding]; other site 755731005585 homodimer interface [polypeptide binding]; other site 755731005586 Ribosomal interacting GTPase YjeQ/EngC, a circularly permuted subfamily of the Ras GTPases; Region: YjeQ_EngC; cd01854 755731005587 GTPase/Zn-binding domain interface [polypeptide binding]; other site 755731005588 GTP/Mg2+ binding site [chemical binding]; other site 755731005589 G4 box; other site 755731005590 G5 box; other site 755731005591 G1 box; other site 755731005592 Switch I region; other site 755731005593 G2 box; other site 755731005594 G3 box; other site 755731005595 Switch II region; other site 755731005596 Pentose-5-phosphate-3-epimerase [Carbohydrate transport and metabolism]; Region: Rpe; COG0036 755731005597 Ribulose-5-phosphate 3-epimerase (RPE). This enzyme catalyses the interconversion of D-ribulose 5-phosphate (Ru5P) into D-xylulose 5-phosphate, as part of the Calvin cycle (reductive pentose phosphate pathway) in chloroplasts and in the oxidative pentose...; Region: RPE; cd00429 755731005598 substrate binding site [chemical binding]; other site 755731005599 hexamer interface [polypeptide binding]; other site 755731005600 metal binding site [ion binding]; metal-binding site 755731005601 Thiamine pyrophosphokinase; Region: TPK; cd07995 755731005602 thiamine pyrophosphokinase; Region: thi_PPkinase; TIGR01378 755731005603 active site 755731005604 dimerization interface [polypeptide binding]; other site 755731005605 thiamine binding site [chemical binding]; other site 755731005606 C1 Peptidase family (MEROPS database nomenclature), also referred to as the papain family; composed of two subfamilies of cysteine peptidases (CPs), C1A (papain) and C1B (bleomycin hydrolase). Papain-like enzymes are mostly endopeptidases with some...; Region: Peptidase_C1; cd02619 755731005607 active site 755731005608 Flavodoxin-like fold; Region: Flavodoxin_2; cl00438 755731005609 Membrane carboxypeptidase/penicillin-binding protein [Cell envelope biogenesis, outer membrane]; Region: MrcA; COG5009 755731005610 DNA/RNA non-specific endonuclease; Region: Endonuclea_NS_2; cl17626 755731005611 Domain of unknown function (DUF4157); Region: DUF4157; pfam13699 755731005612 Regulators of stationary/sporulation gene expression [Transcription]; Region: AbrB; COG2002 755731005613 SpoVT / AbrB like domain; Region: SpoVT_AbrB; smart00966 755731005614 TfoX N-terminal domain; Region: TfoX_N; pfam04993 755731005615 Protein of unknown function (DUF2992); Region: DUF2992; pfam11208 755731005616 Cupin domain; Region: Cupin_2; pfam07883 755731005617 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 755731005618 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 755731005619 Right handed beta helix region; Region: Beta_helix; pfam13229 755731005620 Glyco_18 domain; Region: Glyco_18; smart00636 755731005621 The GH18 (glycosyl hydrolases, family 18) type II chitinases hydrolyze chitin, an abundant polymer of N-acetylglucosamine and have been identified in bacteria, fungi, insects, plants, viruses, and protozoan parasites. The structure of this domain is an...; Region: GH18_chitinase; cd06548 755731005622 active site 755731005623 Dockerin type I repeat; Region: Dockerin_1; pfam00404 755731005624 Chorismase synthase, the enzyme catalyzing the final step of the shikimate pathway; Region: Chorismate_synthase; cl00323 755731005625 Chorismase synthase, the enzyme catalyzing the final step of the shikimate pathway; Region: Chorismate_synthase; cl00323 755731005626 Tetramer interface [polypeptide binding]; other site 755731005627 FMN-binding site [chemical binding]; other site 755731005628 active site 755731005629 ferredoxin-type protein, NapH/MauN family; Region: napH_; TIGR02163 755731005630 4Fe-4S binding domain; Region: Fer4_5; pfam12801 755731005631 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 755731005632 acyl-activating enzyme (AAE) consensus motif; other site 755731005633 active site 755731005634 AMP binding site [chemical binding]; other site 755731005635 CoA binding site [chemical binding]; other site 755731005636 shikimate kinase; Reviewed; Region: aroK; PRK00131 755731005637 Shikimate kinase (SK) is the fifth enzyme in the shikimate pathway, a seven-step biosynthetic pathway which converts erythrose-4-phosphate to chorismic acid, found in bacteria, fungi and plants. Chorismic acid is a important intermediate in the synthesis...; Region: SK; cd00464 755731005638 ADP binding site [chemical binding]; other site 755731005639 magnesium binding site [ion binding]; other site 755731005640 putative shikimate binding site; other site 755731005641 Carbohydrate Binding Module 6 (CBM6); appended to several carbohydrate binding enzymes, including several glycoside hydrolase (GH) family 26 mannanase domains; Region: CBM6_mannanase-like; cd04086 755731005642 putative metal binding site [ion binding]; other site 755731005643 Glycosyl hydrolase family 26; Region: Glyco_hydro_26; pfam02156 755731005644 Dockerin type I repeat; Region: Dockerin_1; pfam00404 755731005645 Haloacid dehalogenase-like hydrolase; Region: HAD_2; pfam13419 755731005646 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 755731005647 motif II; other site 755731005648 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cl17257 755731005649 malonyl CoA-acyl carrier protein transacylase; Region: fabD; TIGR00128 755731005650 Acyl transferase domain in polyketide synthase (PKS) enzymes; Region: PKS_AT; smart00827 755731005651 TlpA-like family; composed of TlpA, ResA, DsbE and similar proteins. TlpA, ResA and DsbE are bacterial protein disulfide reductases with important roles in cytochrome maturation. They are membrane-anchored proteins with a soluble TRX domain containing a...; Region: TlpA_like_family; cd02966 755731005652 Thioredoxin-like; Region: Thioredoxin_8; pfam13905 755731005653 catalytic residues [active] 755731005654 Cytochrome c biogenesis protein [Posttranslational modification, protein turnover, chaperones]; Region: CcdA; COG0785 755731005655 Cytochrome C biogenesis protein transmembrane region; Region: DsbD; pfam02683 755731005656 Membrane-associated phospholipid phosphatase [Lipid metabolism]; Region: PgpB; COG0671 755731005657 PAP2_like proteins, a super-family of histidine phosphatases and vanadium haloperoxidases, includes type 2 phosphatidic acid phosphatase or lipid phosphate phosphatase (LPP), Glucose-6-phosphatase, Phosphatidylglycerophosphatase B and bacterial acid...; Region: PAP2_like; cl00474 755731005658 active site 755731005659 Polymerase and Histidinol Phosphatase domain; Region: PHP; cl17102 755731005660 active site 755731005661 ABC transporter, ATP-binding subunit, PQQ-dependent alcohol dehydrogenase system; Region: PQQ_ABC_ATP; TIGR03864 755731005662 ATP-binding cassette domain of the lipid transporters, subfamily A; Region: ABC_subfamily_A; cd03263 755731005663 Walker A/P-loop; other site 755731005664 ATP binding site [chemical binding]; other site 755731005665 Q-loop/lid; other site 755731005666 ABC transporter signature motif; other site 755731005667 Walker B; other site 755731005668 D-loop; other site 755731005669 H-loop/switch region; other site 755731005670 ABC-type multidrug transport system, permease component [Defense mechanisms]; Region: COG0842 755731005671 ABC-2 type transporter; Region: ABC2_membrane; cl17235 755731005672 Domain of unknown function (DUF362); Region: DUF362; pfam04015 755731005673 Predicted permeases [General function prediction only]; Region: COG0701 755731005674 Condensation domain; Region: Condensation; pfam00668 755731005675 The adenylation domain of nonribosomal peptide synthetases (NRPS); Region: A_NRPS; cd05930 755731005676 amino acid adenylation domain; Region: AA-adenyl-dom; TIGR01733 755731005677 acyl-activating enzyme (AAE) consensus motif; other site 755731005678 AMP binding site [chemical binding]; other site 755731005679 Phosphopantetheine attachment site; Region: PP-binding; pfam00550 755731005680 Condensation domain; Region: Condensation; pfam00668 755731005681 Non-ribosomal peptide synthetase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: EntF; COG1020 755731005682 HxxPF-repeated domain; Region: HxxPF_rpt; pfam13745 755731005683 The adenylation domain of nonribosomal peptide synthetases (NRPS); Region: A_NRPS; cd05930 755731005684 acyl-activating enzyme (AAE) consensus motif; other site 755731005685 AMP binding site [chemical binding]; other site 755731005686 Phosphopantetheine attachment site; Region: PP-binding; pfam00550 755731005687 Condensation domain; Region: Condensation; pfam00668 755731005688 Non-ribosomal peptide synthetase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: EntF; COG1020 755731005689 HxxPF-repeated domain; Region: HxxPF_rpt; pfam13745 755731005690 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 755731005691 The adenylation domain of nonribosomal peptide synthetases (NRPS), including Streptoalloteichus tallysomycin biosynthesis genes; Region: A_NRPS_TlmIV_like; cd12114 755731005692 amino acid adenylation domain; Region: AA-adenyl-dom; TIGR01733 755731005693 acyl-activating enzyme (AAE) consensus motif; other site 755731005694 AMP binding site [chemical binding]; other site 755731005695 Phosphopantetheine attachment site; Region: PP-binding; pfam00550 755731005696 phosphoenolpyruvate synthase; Validated; Region: PRK06241 755731005697 Pyruvate phosphate dikinase, PEP/pyruvate binding domain; Region: PPDK_N; pfam01326 755731005698 PEP-utilising enzyme, mobile domain; Region: PEP-utilizers; pfam00391 755731005699 Amidohydrolase; Region: Amidohydro_2; pfam04909 755731005700 Transcriptional regulators [Transcription]; Region: PurR; COG1609 755731005701 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 755731005702 DNA binding site [nucleotide binding] 755731005703 domain linker motif; other site 755731005704 Ligand binding domain of the LacI tanscriptional regulator family belonging to the type I periplasmic-binding fold protein superfamily; Region: PBP1_LacI_sugar_binding_like; cd06267 755731005705 dimerization interface [polypeptide binding]; other site 755731005706 ligand binding site [chemical binding]; other site 755731005707 A predicted NlpC/p60-like peptidase; Region: BtrH; pfam14399 755731005708 alpha-galactosidase; Region: PLN02692 755731005709 alpha-galactosidase; Region: PLN02808; cl17638 755731005710 Dockerin type I repeat; Region: Dockerin_1; pfam00404 755731005711 Glycosyl hydrolase family 43; Region: GH43_4; cd08983 755731005712 active site 755731005713 Concanavalin A-like lectin/glucanases superfamily; Region: Laminin_G_3; pfam13385 755731005714 Bacterial Ig-like domain (group 4); Region: Big_4; pfam07532 755731005715 Glycosyl hydrolase family 43; Region: GH43_1; cd08980 755731005716 active site 755731005717 Glycosyl hydrolase families: GH43, GH62, GH32, GH68; Region: GH43_62_32_68; cl14647 755731005718 active site 755731005719 Dockerin type I repeat; Region: Dockerin_1; pfam00404 755731005720 Concanavalin A-like lectin/glucanases superfamily; Region: Laminin_G_3; pfam13385 755731005721 DAK2 domain; Region: Dak2; pfam02734 755731005722 dihydroxyacetone kinase subunit DhaK; Provisional; Region: PRK14481; cl10557 755731005723 Dihydroxyacetone kinase [Carbohydrate transport and metabolism]; Region: DAK1; COG2376 755731005724 ribose-5-phosphate isomerase B; Provisional; Region: PRK05571 755731005725 short chain dehydrogenase; Provisional; Region: PRK06841 755731005726 classical (c) SDRs; Region: SDR_c; cd05233 755731005727 NAD(P) binding site [chemical binding]; other site 755731005728 active site 755731005729 ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: RbsB; COG1879 755731005730 Periplasmic binding proteins specific to rhizopines; Region: PBP1_rhizopine_binding_like; cd06301 755731005731 putative ligand binding site [chemical binding]; other site 755731005732 Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653 755731005733 Transmembrane subunit (TM) of Escherichia coli AraH and related proteins. E. coli AraH is the TM of a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of the monosaccharide arabinose. This group...; Region: TM_PBP1_transp_AraH_like; cd06579 755731005734 TM-ABC transporter signature motif; other site 755731005735 ABC-type sugar transport system, ATPase component [Carbohydrate transport and metabolism]; Region: MglA; COG1129 755731005736 First domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_I; cd03216 755731005737 Walker A/P-loop; other site 755731005738 ATP binding site [chemical binding]; other site 755731005739 Q-loop/lid; other site 755731005740 ABC transporter signature motif; other site 755731005741 Walker B; other site 755731005742 D-loop; other site 755731005743 H-loop/switch region; other site 755731005744 Second domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_II; cd03215 755731005745 Response regulator receiver domain; Region: Response_reg; pfam00072 755731005746 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 755731005747 active site 755731005748 phosphorylation site [posttranslational modification] 755731005749 intermolecular recognition site; other site 755731005750 dimerization interface [polypeptide binding]; other site 755731005751 AraC-type DNA-binding domain-containing proteins [Transcription]; Region: AraC; COG2207 755731005752 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 755731005753 Predicted signal transduction protein with a C-terminal ATPase domain [Signal transduction mechanisms]; Region: COG2972 755731005754 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 755731005755 dimerization interface [polypeptide binding]; other site 755731005756 Histidine kinase; Region: His_kinase; pfam06580 755731005757 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 755731005758 ATP binding site [chemical binding]; other site 755731005759 Mg2+ binding site [ion binding]; other site 755731005760 G-X-G motif; other site 755731005761 integral membrane protein, TerC family; Region: R_switched_Alx; TIGR03718 755731005762 Anaerobic glycerol-3-phosphate dehydrogenase [Amino acid transport and metabolism]; Region: GlpB; cl17730 755731005763 thioredoxin-disulfide reductase; Region: TRX_reduct; TIGR01292 755731005764 sulfite reductase, subunit C; Region: sulfite_red_C; TIGR02912 755731005765 Nitrite/Sulfite reductase ferredoxin-like half domain; Region: NIR_SIR_ferr; pfam03460 755731005766 4Fe-4S binding domain; Region: Fer4; cl02805 755731005767 GTPases - Sulfate adenylate transferase subunit 1 [Inorganic ion transport and metabolism]; Region: CysN; COG2895 755731005768 CysN, together with protein CysD, forms the ATP sulfurylase (ATPS) complex; Region: CysN_ATPS; cd04166 755731005769 CysD dimerization site [polypeptide binding]; other site 755731005770 G1 box; other site 755731005771 putative GEF interaction site [polypeptide binding]; other site 755731005772 GTP/Mg2+ binding site [chemical binding]; other site 755731005773 Switch I region; other site 755731005774 G2 box; other site 755731005775 G3 box; other site 755731005776 Switch II region; other site 755731005777 G4 box; other site 755731005778 G5 box; other site 755731005779 CysN_NodQ_II: This subfamily represents the domain II of the large subunit of ATP sulfurylase (ATPS): CysN or the N-terminal portion of NodQ, found mainly in proteobacteria and homologous to the domain II of EF-Tu. Escherichia coli ATPS consists of CysN...; Region: CysN_NodQ_II; cd03695 755731005780 TCysN_NoDQ_II: This subfamily represents the domain II of the large subunit of ATP sulfurylase (ATPS): CysN or the N-terminal portion of NodQ, found mainly in proteobacteria and homologous to the domain II of EF-Tu. Escherichia coli ATPS consists of CysN...; Region: CysN_NoDQ_III; cd04095 755731005781 Nucleoside/nucleotide kinase (NK) is a protein superfamily consisting of multiple families of enzymes that share structural similarity and are functionally related to the catalysis of the reversible phosphate group transfer from nucleoside triphosphates...; Region: NK; cl17190 755731005782 sulfate adenylyltransferase, small subunit; Region: CysD; TIGR02039 755731005783 This domain is found in phosphoadenosine phosphosulphate (PAPS) reductase enzymes or PAPS sulphotransferase. PAPS reductase is part of the adenine nucleotide alpha hydrolases superfamily also including N type ATP PPases and ATP sulphurylases. A highly...; Region: PAPS_reductase; cd01713 755731005784 Active Sites [active] 755731005785 3'-phosphoadenosine 5'-phosphosulfate sulfotransferase (PAPS reductase)/FAD synthetase and related enzymes [Amino acid transport and metabolism / Coenzyme metabolism]; Region: CysH; COG0175 755731005786 This domain is found in phosphoadenosine phosphosulphate (PAPS) reductase enzymes or PAPS sulphotransferase. PAPS reductase is part of the adenine nucleotide alpha hydrolases superfamily also including N type ATP PPases and ATP sulphurylases. A highly...; Region: PAPS_reductase; cd01713 755731005787 Active Sites [active] 755731005788 Transcriptional regulator/sugar kinase [Transcription / Carbohydrate transport and metabolism]; Region: NagC; COG1940 755731005789 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cd00012 755731005790 nucleotide binding site [chemical binding]; other site 755731005791 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cl17037 755731005792 ABC-type sulfate/molybdate transport systems, ATPase component [Inorganic ion transport and metabolism]; Region: CysA; COG1118 755731005793 ATP-binding cassette domain of the sulfate transporter; Region: ABC_CysA_sulfate_importer; cd03296 755731005794 Walker A/P-loop; other site 755731005795 ATP binding site [chemical binding]; other site 755731005796 Q-loop/lid; other site 755731005797 ABC transporter signature motif; other site 755731005798 Walker B; other site 755731005799 D-loop; other site 755731005800 H-loop/switch region; other site 755731005801 TOBE-like domain; Region: TOBE_3; pfam12857 755731005802 sulfate transport protein; Provisional; Region: cysT; CHL00187 755731005803 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 755731005804 dimer interface [polypeptide binding]; other site 755731005805 conserved gate region; other site 755731005806 putative PBP binding loops; other site 755731005807 ABC-ATPase subunit interface; other site 755731005808 ABC-type sulfate transport system, permease component [Posttranslational modification, protein turnover, chaperones]; Region: CysU; COG0555 755731005809 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 755731005810 dimer interface [polypeptide binding]; other site 755731005811 conserved gate region; other site 755731005812 putative PBP binding loops; other site 755731005813 ABC-ATPase subunit interface; other site 755731005814 ABC-type sulfate transport system, periplasmic component [Inorganic ion transport and metabolism]; Region: Sbp; COG1613 755731005815 Bacterial extracellular solute-binding protein; Region: SBP_bac_11; pfam13531 755731005816 CotH protein; Region: CotH; pfam08757 755731005817 endoglucanase; Region: PLN02420 755731005818 Glycosyl hydrolase family 9; Region: Glyco_hydro_9; cl02959 755731005819 Cellulose binding domain; Region: CBM_3; pfam00942 755731005820 Dockerin type I repeat; Region: Dockerin_1; pfam00404 755731005821 A predicted NlpC/p60-like peptidase; Region: BtrH; pfam14399 755731005822 Peptidase family C39 mostly contains bacteriocin-processing endopeptidases from bacteria. The cysteine peptidases in family C39 cleave the "double-glycine" leader peptides from the precursors of various bacteriocins (mostly non-lantibiotic); Region: Peptidase_C39_like; cl00296 755731005823 putative active site [active] 755731005824 Sulfite exporter TauE/SafE; Region: TauE; pfam01925 755731005825 Protein of unknown function (DUF1634); Region: DUF1634; pfam07843 755731005826 40-residue YVTN family beta-propeller repeat; Region: beta_rpt_yvtn; TIGR02276 755731005827 PQQ-dependent catabolism-associated beta-propeller protein; Region: PQQ_ABC_repeats; TIGR03866 755731005828 40-residue YVTN family beta-propeller repeat; Region: beta_rpt_yvtn; TIGR02276 755731005829 40-residue YVTN family beta-propeller repeat; Region: beta_rpt_yvtn; TIGR02276 755731005830 40-residue YVTN family beta-propeller repeat; Region: beta_rpt_yvtn; TIGR02276 755731005831 40-residue YVTN family beta-propeller repeat; Region: beta_rpt_yvtn; TIGR02276 755731005832 Cell wall-associated hydrolases (invasion-associated proteins) [Cell envelope biogenesis, outer membrane]; Region: Spr; COG0791 755731005833 NlpC/P60 family; Region: NLPC_P60; pfam00877 755731005834 Escherichia coli YbbF/LpxH and related proteins, metallophosphatase domain; Region: MPP_YbbF-LpxH; cd07398 755731005835 putative active site [active] 755731005836 putative metal binding site [ion binding]; other site 755731005837 site-specific tyrosine recombinase XerC; Reviewed; Region: xerC; PRK00236 755731005838 DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213 755731005839 active site 755731005840 DNA binding site [nucleotide binding] 755731005841 Int/Topo IB signature motif; other site 755731005842 Predicted periplasmic protein (DUF2233); Region: DUF2233; pfam09992 755731005843 Bacterial SH3 domain; Region: SH3_3; pfam08239 755731005844 sensory histidine kinase DcuS; Provisional; Region: PRK11086 755731005845 Response regulator of the LytR/AlgR family [Transcription / Signal transduction mechanisms]; Region: LytT; COG3279 755731005846 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 755731005847 active site 755731005848 phosphorylation site [posttranslational modification] 755731005849 intermolecular recognition site; other site 755731005850 dimerization interface [polypeptide binding]; other site 755731005851 LytTr DNA-binding domain; Region: LytTR; smart00850 755731005852 Nitrogenase_vnfN_like: VnfN subunit of the VnfEN complex-like. This group in addition to VnfN contains a subset of the beta subunit of the nitrogenase MoFe protein and NifN-like proteins. The nitrogenase enzyme system catalyzes the ATP-dependent...; Region: Nitrogenase_VnfN_like; cd01971 755731005853 Nitrogenase component 1 type Oxidoreductase; Region: Oxidored_nitro; pfam00148 755731005854 The nitrogenase enzyme system catalyzes the ATP-dependent reduction of dinitrogen to ammonia. This group contains both alpha and beta subunits of component 1 of the three known genetically distinct types of nitrogenase systems: a molybdenum-dependent; Region: Oxidoreductase_nitrogenase; cl02775 755731005855 Nitrogenase component 1 type Oxidoreductase; Region: Oxidored_nitro; pfam00148 755731005856 RNA polymerase sigma factor, sigma-70 family; Region: sigma70-ECF; TIGR02937 755731005857 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 755731005858 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 755731005859 DNA binding residues [nucleotide binding] 755731005860 Domain of unknown function (DUF2935); Region: DUF2935; pfam11155 755731005861 Domain of unknown function (DUF2935); Region: DUF2935; pfam11155 755731005862 DNA gyrase inhibitor [DNA replication, recombination, and repair]; Region: COG3449 755731005863 H+ Antiporter protein; Region: 2A0121; TIGR00900 755731005864 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 755731005865 putative substrate translocation pore; other site 755731005866 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 755731005867 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 755731005868 non-specific DNA binding site [nucleotide binding]; other site 755731005869 salt bridge; other site 755731005870 sequence-specific DNA binding site [nucleotide binding]; other site 755731005871 desulfoferrodoxin; Region: dfx_rbo; TIGR00320 755731005872 Superoxide reductase-like (SORL) domain; present in a family of mononuclear non-heme iron proteins that includes superoxide reductase and desulfoferrodoxin. Superoxide reductase-like proteins scavenge superoxide anion radicals as a defense mechanism...; Region: SORL; cl00014 755731005873 non-heme iron binding site [ion binding]; other site 755731005874 GIY-YIG domain of LuxR and ArsR family transcriptional regulators, and uncharacterized hypothetical proteins found in bacteria; Region: GIY-YIG_LuxR_like; cd10451 755731005875 GIY-YIG motif/motif A; other site 755731005876 Nucleoside/nucleotide kinase (NK) is a protein superfamily consisting of multiple families of enzymes that share structural similarity and are functionally related to the catalysis of the reversible phosphate group transfer from nucleoside triphosphates...; Region: NK; cl17190 755731005877 AAA domain; Region: AAA_33; pfam13671 755731005878 active site 755731005879 ATPase components of ABC transporters with duplicated ATPase domains [General function prediction only]; Region: Uup; COG0488 755731005880 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 755731005881 ABC transporter; Region: ABC_tran_2; pfam12848 755731005882 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 755731005883 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 755731005884 H+ Antiporter protein; Region: 2A0121; TIGR00900 755731005885 putative substrate translocation pore; other site 755731005886 phosphoenolpyruvate synthase; Validated; Region: PRK06241 755731005887 Pyruvate phosphate dikinase, PEP/pyruvate binding domain; Region: PPDK_N; pfam01326 755731005888 PEP-utilising enzyme, mobile domain; Region: PEP-utilizers; pfam00391 755731005889 Cellulase (glycosyl hydrolase family 5); Region: Cellulase; pfam00150 755731005890 Dockerin type I repeat; Region: Dockerin_1; pfam00404 755731005891 N-terminal Early set domain associated with the catalytic domain of cellulase; Region: E_set_Cellulase_N; cd02850 755731005892 Glycosyl hydrolase family 9; Region: Glyco_hydro_9; cl02959 755731005893 Dockerin type I repeat; Region: Dockerin_1; pfam00404 755731005894 AraC-like ligand binding domain; Region: AraC_binding; pfam02311 755731005895 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 755731005896 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 755731005897 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 755731005898 Cation transport ATPase [Inorganic ion transport and metabolism]; Region: MgtA; COG0474 755731005899 Cation transporter/ATPase, N-terminus; Region: Cation_ATPase_N; pfam00690 755731005900 E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122 755731005901 Putative hydrolase of sodium-potassium ATPase alpha subunit; Region: Hydrolase_like2; pfam13246 755731005902 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 755731005903 motif II; other site 755731005904 Cation transporting ATPase, C-terminus; Region: Cation_ATPase_C; pfam00689 755731005905 serine hydroxymethyltransferase; Reviewed; Region: glyA; PRK00011 755731005906 Serine-glycine hydroxymethyltransferase (SHMT). This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). SHMT carries out interconversion of serine and glycine; it catalyzes the transfer of hydroxymethyl...; Region: SHMT; cd00378 755731005907 dimer interface [polypeptide binding]; other site 755731005908 active site 755731005909 glycine-pyridoxal phosphate binding site [chemical binding]; other site 755731005910 folate binding site [chemical binding]; other site 755731005911 Hydrogenase maturation factor [Posttranslational modification, protein turnover, chaperones]; Region: HypE; COG0309 755731005912 AIR synthase (PurM) related protein, subgroup 1 of unknown function. The family of PurM related proteins includes Hydrogen expression/formation protein HypE, AIR synthases, FGAM synthase and Selenophosphate synthetase (SelD). They all contain two...; Region: PurM-like1; cd06061 755731005913 dimerization interface [polypeptide binding]; other site 755731005914 putative ATP binding site [chemical binding]; other site 755731005915 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG1655 755731005916 Uncharacterized protein conserved in bacteria (DUF2225); Region: DUF2225; pfam09986 755731005917 thiamine biosynthesis protein ThiI; Provisional; Region: PRK01565 755731005918 THUMP domain of thiamine biosynthesis protein ThiI; Region: THUMP_ThiI; cd11716 755731005919 ThiI is required for thiazole synthesis in the thiamine biosynthesis pathway. It belongs to the Adenosine Nucleotide Hydrolysis suoerfamily and predicted to bind to Adenosine nucleotide; Region: ThiI; cd01712 755731005920 Ligand Binding Site [chemical binding]; other site 755731005921 cysteine desulfurase NifS; Region: FeS_nifS; TIGR03402 755731005922 Cysteine sulfinate desulfinase/cysteine desulfurase and related enzymes [Amino acid transport and metabolism]; Region: NifS; COG1104 755731005923 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 755731005924 catalytic residue [active] 755731005925 4Fe-4S dicluster domain; Region: Fer4_7; pfam12838 755731005926 RPB11 and RPB3 subunits of RNA polymerase; Region: RNAP_RPB11_RPB3; cl11409 755731005927 4Fe-4S dicluster domain; Region: Fer4_7; pfam12838 755731005928 Ni,Fe-hydrogenase III small subunit [Energy production and conversion]; Region: COG3260 755731005929 Respiratory-chain NADH dehydrogenase, 30 Kd subunit; Region: Complex1_30kDa; pfam00329 755731005930 NADH dehydrogenase subunit D; Validated; Region: PRK06075; cl17338 755731005931 Ni,Fe-hydrogenase III large subunit [Energy production and conversion]; Region: HycE; COG3261 755731005932 proton-translocating NADH-quinone oxidoreductase, chain N; Region: NDH_I_N; TIGR01770 755731005933 NADH-Ubiquinone/plastoquinone (complex I), various chains; Region: Oxidored_q1; pfam00361 755731005934 Hydrogenase 4 membrane component (E) [Energy production and conversion]; Region: HyfE; cl17899 755731005935 Formate hydrogenlyase subunit 4 [Energy production and conversion]; Region: HyfC; COG0650 755731005936 NADH dehydrogenase; Region: NADHdh; cl00469 755731005937 hydrogenase 4 subunit B; Validated; Region: PRK06521 755731005938 NADH-Ubiquinone/plastoquinone (complex I), various chains; Region: Oxidored_q1; pfam00361 755731005939 Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118 755731005940 LexA repressor; Validated; Region: PRK00215 755731005941 LexA DNA binding domain; Region: LexA_DNA_bind; pfam01726 755731005942 Peptidase S24 LexA-like proteins are involved in the SOS response leading to the repair of single-stranded DNA within the bacterial cell. This family includes: the lambda repressor CI/C2 family and related bacterial prophage repressor proteins; LexA (EC...; Region: S24_LexA-like; cd06529 755731005943 Catalytic site [active] 755731005944 bacterial Hfq-like; Region: Hfq; cd01716 755731005945 hexamer interface [polypeptide binding]; other site 755731005946 Sm1 motif; other site 755731005947 RNA binding site [nucleotide binding]; other site 755731005948 Sm2 motif; other site 755731005949 tRNA delta(2)-isopentenylpyrophosphate transferase; Reviewed; Region: miaA; PRK00091 755731005950 tRNA delta(2)-isopentenylpyrophosphate transferase [Translation, ribosomal structure and biogenesis]; Region: MiaA; COG0324 755731005951 DNA mismatch repair protein; Reviewed; Region: mutL; PRK00095 755731005952 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 755731005953 ATP binding site [chemical binding]; other site 755731005954 Mg2+ binding site [ion binding]; other site 755731005955 G-X-G motif; other site 755731005956 MutL_Trans: transducer domain, having a ribosomal S5 domain 2-like fold, conserved in the C-terminal domain of DNA mismatch repair (MutL/MLH1/PMS2) family. This transducer domain is homologous to the second domain of the DNA gyrase B subunit, which is...; Region: MutL_Trans; cd00782 755731005957 ATP binding site [chemical binding]; other site 755731005958 MutL C terminal dimerisation domain; Region: MutL_C; pfam08676 755731005959 DNA mismatch repair protein MutS; Provisional; Region: PRK05399 755731005960 MutS domain I; Region: MutS_I; pfam01624 755731005961 MutS domain II; Region: MutS_II; pfam05188 755731005962 MutS domain III; Region: MutS_III; pfam05192 755731005963 ATP-binding cassette domain of MutS1 homolog; Region: ABC_MutS1; cd03284 755731005964 Walker A/P-loop; other site 755731005965 ATP binding site [chemical binding]; other site 755731005966 Q-loop/lid; other site 755731005967 ABC transporter signature motif; other site 755731005968 Walker B; other site 755731005969 D-loop; other site 755731005970 H-loop/switch region; other site 755731005971 Protein of unknown function (DUF964); Region: DUF964; pfam06133 755731005972 (dimethylallyl)adenosine tRNA methylthiotransferase; Provisional; Region: PRK14328 755731005973 Uncharacterized protein family UPF0004; Region: UPF0004; pfam00919 755731005974 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 755731005975 FeS/SAM binding site; other site 755731005976 TRAM domain; Region: TRAM; pfam01938 755731005977 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 755731005978 Acetyltransferases [General function prediction only]; Region: RimI; COG0456 755731005979 Coenzyme A binding pocket [chemical binding]; other site 755731005980 PaaI_thioesterase is a tetrameric acyl-CoA thioesterase with a hot dog fold and one of several proteins responsible for phenylacetic acid (PA) degradation in bacteria. Although orthologs of PaaI exist in archaea and eukaryotes, their function has not...; Region: PaaI_thioesterase; cd03443 755731005981 CoenzymeA binding site [chemical binding]; other site 755731005982 subunit interaction site [polypeptide binding]; other site 755731005983 PHB binding site; other site 755731005984 YlzJ-like protein; Region: YlzJ; pfam14035 755731005985 Clp protease; Region: CLP_protease; pfam00574 755731005986 Caseinolytic protease (ClpP) is an ATP-dependent protease; Region: Clp_protease_like; cl15763 755731005987 active site 755731005988 dipicolinate synthase subunit B; Reviewed; Region: spoVFB; PRK08305 755731005989 dipicolinate synthase subunit A; Reviewed; Region: PRK08306 755731005990 Formate/glycerate dehydrogenases, D-specific 2-hydroxy acid dehydrogenases and related dehydrogenases; Region: FDH_GDH_like; cl17240 755731005991 NAD binding site [chemical binding]; other site 755731005992 Predicted Zn-dependent peptidases [General function prediction only]; Region: PqqL; COG0612 755731005993 Insulinase (Peptidase family M16); Region: Peptidase_M16; pfam00675 755731005994 Peptidase M16 inactive domain; Region: Peptidase_M16_C; pfam05193 755731005995 polynucleotide phosphorylase/polyadenylase; Provisional; Region: PRK11824 755731005996 Polyribonucleotide nucleotidyltransferase, repeat 1; Region: RNase_PH_PNPase_1; cd11363 755731005997 RNase E interface [polypeptide binding]; other site 755731005998 trimer interface [polypeptide binding]; other site 755731005999 Polyribonucleotide nucleotidyltransferase, RNA binding domain; Region: PNPase; pfam03726 755731006000 Polyribonucleotide nucleotidyltransferase, repeat 2; Region: RNase_PH_PNPase_2; cd11364 755731006001 RNase E interface [polypeptide binding]; other site 755731006002 trimer interface [polypeptide binding]; other site 755731006003 active site 755731006004 Polynucleotide phosphorylase (PNPase) K homology RNA-binding domain (KH). PNPase is a polyribonucleotide nucleotidyl transferase that degrades mRNA in prokaryotes and plant chloroplasts. The C-terminal region of PNPase contains domains homologous to...; Region: PNPase_KH; cd02393 755731006005 putative nucleic acid binding region [nucleotide binding]; other site 755731006006 G-X-X-G motif; other site 755731006007 S1_PNPase: Polynucleotide phosphorylase (PNPase), ), S1-like RNA-binding domain. PNPase is a polyribonucleotide nucleotidyl transferase that degrades mRNA. It is a trimeric multidomain protein. The C-terminus contains the S1 domain which binds ssRNA; Region: S1_PNPase; cd04472 755731006008 RNA binding site [nucleotide binding]; other site 755731006009 domain interface; other site 755731006010 Ribosomal protein S15 (prokaryotic)_S13 (eukaryotic) binds the central domain of 16S rRNA and is required for assembly of the small ribosomal subunit and for intersubunit association, thus representing a key element in the assembly of the whole ribosome; Region: Ribosomal_S15p_S13e; cd00353 755731006011 16S/18S rRNA binding site [nucleotide binding]; other site 755731006012 S13e-L30e interaction site [polypeptide binding]; other site 755731006013 25S rRNA binding site [nucleotide binding]; other site 755731006014 MoxR-like ATPases [General function prediction only]; Region: COG0714 755731006015 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 755731006016 Walker A motif; other site 755731006017 ATP binding site [chemical binding]; other site 755731006018 Walker B motif; other site 755731006019 arginine finger; other site 755731006020 Uncharacterized conserved protein (some members contain a von Willebrand factor type A (vWA) domain) [General function prediction only]; Region: COG1721 755731006021 Protein of unknown function DUF58; Region: DUF58; pfam01882 755731006022 Transglutaminase-like enzymes, putative cysteine proteases [Amino acid transport and metabolism]; Region: COG1305 755731006023 Transglutaminase-like superfamily; Region: Transglut_core; pfam01841 755731006024 Permeases of the drug/metabolite transporter (DMT) superfamily [Carbohydrate transport and metabolism / Amino acid transport and metabolism / General function prediction only]; Region: RhaT; COG0697 755731006025 EamA-like transporter family; Region: EamA; pfam00892 755731006026 EamA-like transporter family; Region: EamA; pfam00892 755731006027 Acyltransferase family; Region: Acyl_transf_3; pfam01757 755731006028 Predicted O-acyltransferase [General function prediction only]; Region: COG3274 755731006029 alanine racemase; Reviewed; Region: alr; PRK00053 755731006030 Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzymes; Region: PLPDE_III; cl00261 755731006031 pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site 755731006032 catalytic residue [active] 755731006033 D-alanyl-D-alanine carboxypeptidase; Region: VanY; pfam02557 755731006034 D-alanyl-alanine synthetase A; Reviewed; Region: ddl; PRK01966 755731006035 D-ala D-ala ligase N-terminus; Region: Dala_Dala_lig_N; pfam01820 755731006036 D-ala D-ala ligase C-terminus; Region: Dala_Dala_lig_C; pfam07478 755731006037 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 755731006038 dimer interface [polypeptide binding]; other site 755731006039 phosphorylation site [posttranslational modification] 755731006040 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 755731006041 ATP binding site [chemical binding]; other site 755731006042 Mg2+ binding site [ion binding]; other site 755731006043 G-X-G motif; other site 755731006044 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 755731006045 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 755731006046 active site 755731006047 phosphorylation site [posttranslational modification] 755731006048 intermolecular recognition site; other site 755731006049 dimerization interface [polypeptide binding]; other site 755731006050 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 755731006051 DNA binding site [nucleotide binding] 755731006052 heavy metal sensor kinase; Region: cztS_silS_copS; TIGR01386 755731006053 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 755731006054 dimerization interface [polypeptide binding]; other site 755731006055 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 755731006056 dimer interface [polypeptide binding]; other site 755731006057 phosphorylation site [posttranslational modification] 755731006058 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 755731006059 ATP binding site [chemical binding]; other site 755731006060 Mg2+ binding site [ion binding]; other site 755731006061 G-X-G motif; other site 755731006062 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 755731006063 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 755731006064 active site 755731006065 phosphorylation site [posttranslational modification] 755731006066 intermolecular recognition site; other site 755731006067 dimerization interface [polypeptide binding]; other site 755731006068 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 755731006069 DNA binding site [nucleotide binding] 755731006070 Cation transport ATPase [Inorganic ion transport and metabolism]; Region: ZntA; COG2217 755731006071 Heavy-metal-associated domain (HMA) is a conserved domain of approximately 30 amino acid residues found in a number of proteins that transport or detoxify heavy metals, for example, the CPx-type heavy metal ATPases and copper chaperones. HMA domain...; Region: HMA; cd00371 755731006072 metal-binding site [ion binding] 755731006073 Predicted membrane protein (DUF2318); Region: DUF2318; pfam10080 755731006074 Transcriptional regulator [Transcription]; Region: LytR; COG1316 755731006075 Copper amine oxidase N-terminal domain; Region: Cu_amine_oxidN1; pfam07833 755731006076 Trypsin-like peptidase domain; Region: Trypsin_2; pfam13365 755731006077 PDZ domain of tryspin-like serine proteases, such as DegP/HtrA, which are oligomeric proteins involved in heat-shock response, chaperone function, and apoptosis. May be responsible for substrate recognition and/or binding, as most PDZ domains bind...; Region: PDZ_serine_protease; cd00987 755731006078 protein binding site [polypeptide binding]; other site 755731006079 Protein of unknown function (DUF2752); Region: DUF2752; pfam10825 755731006080 Predicted amidohydrolase [General function prediction only]; Region: COG0388 755731006081 Nit1, Nit 2, and related proteins, and the Nit1-like domain of NitFhit (class 10 nitrilases); Region: nit; cd07572 755731006082 putative active site [active] 755731006083 catalytic triad [active] 755731006084 dimer interface [polypeptide binding]; other site 755731006085 Uncharacterized proteins with similarity to Ribonucleotide reductase and Pyruvate formate lyase; Region: RNR_PFL_like_DUF711; cd08025 755731006086 ACT domain proteins similar to the yet uncharacterized Streptococcus pneumoniae ACT domain protein; Region: ACT_1ZPV; cd04872 755731006087 putative DNA modification/repair radical SAM protein; Region: rSAM_link_UDG; TIGR03916 755731006088 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 755731006089 FeS/SAM binding site; other site 755731006090 probable DNA metabolism protein; Region: SAM_7_link_chp; TIGR03915 755731006091 UDP-N-acetylmuramoyl-L-alanyl-D-glutamate synthetase; Provisional; Region: murD; PRK01710 755731006092 Mur ligase middle domain; Region: Mur_ligase_M; pfam08245 755731006093 Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875 755731006094 Methylase of chemotaxis methyl-accepting proteins [Cell motility and secretion / Signal transduction mechanisms]; Region: CheR; COG1352 755731006095 CheR methyltransferase, all-alpha domain; Region: CheR_N; pfam03705 755731006096 CheR methyltransferase, SAM binding domain; Region: CheR; pfam01739 755731006097 4-hydroxy-3-methylbut-2-enyl diphosphate reductase/S1 RNA-binding domain protein; Reviewed; Region: PRK00087 755731006098 LytB protein; Region: LYTB; cl00507 755731006099 S1_RPS1_repeat_ec1_hs1: Ribosomal protein S1 (RPS1) domain. RPS1 is a component of the small ribosomal subunit thought to be involved in the recognition and binding of mRNA's during translation initiation. The bacterial RPS1 domain architecture...; Region: S1_RPS1_repeat_ec1_hs1; cd05687 755731006100 RNA binding site [nucleotide binding]; other site 755731006101 S1_RPS1_repeat_ec2_hs2: Ribosomal protein S1 (RPS1) domain. RPS1 is a component of the small ribosomal subunit thought to be involved in the recognition and binding of mRNA's during translation initiation. The bacterial RPS1 domain architecture...; Region: S1_RPS1_repeat_ec2_hs2; cd04465 755731006102 RNA binding site [nucleotide binding]; other site 755731006103 S1_RPS1_repeat_ec3: Ribosomal protein S1 (RPS1) domain. RPS1 is a component of the small ribosomal subunit thought to be involved in the recognition and binding of mRNA's during translation initiation. The bacterial RPS1 domain architecture consists...; Region: S1_RPS1_repeat_ec3; cd05688 755731006104 RNA binding site [nucleotide binding]; other site 755731006105 S1_RPS1_repeat_hs4: Ribosomal protein S1 (RPS1) domain. RPS1 is a component of the small ribosomal subunit thought to be involved in the recognition and binding of mRNA's during translation initiation. The bacterial RPS1 domain architecture consists...; Region: S1_RPS1_repeat_hs4; cd05692 755731006106 RNA binding site [nucleotide binding]; other site 755731006107 cytidylate kinase; Provisional; Region: cmk; PRK00023 755731006108 Cytidine monophosphate kinase (CMPK) catalyzes the reversible phosphorylation of cytidine monophosphate (CMP) to produce cytidine diphosphate (CDP), using ATP as the preferred phosphoryl donor; Region: CMPK; cd02020 755731006109 CMP-binding site; other site 755731006110 The sites determining sugar specificity; other site 755731006111 Chorismate mutase (AroH) is one of at least five chorismate-utilizing enzymes present in microorganisms that catalyze the rearrangement of chorismate to prephenic acid, the first committed step in the biosynthesis of aromatic amino acids. In prokaryotes; Region: AroH; cd02185 755731006112 homotrimer interaction site [polypeptide binding]; other site 755731006113 active site 755731006114 Histidine Utilizing Protein, the hut operon positive regulatory protein; Region: HutP; cd11640 755731006115 hexamer interface [polypeptide binding]; other site 755731006116 RNA binding site [nucleotide binding]; other site 755731006117 Histidine-zinc binding site [chemical binding]; other site 755731006118 flavoprotein, HI0933 family; Region: TIGR00275 755731006119 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500 755731006120 Transcriptional regulators [Transcription]; Region: RpiR; COG1737 755731006121 Helix-turn-helix domain, rpiR family; Region: HTH_6; pfam01418 755731006122 RpiR-like protein. RpiR contains a SIS (Sugar ISomerase) domain, which is found in many phosphosugar isomerases and phosphosugar binding proteins. In E. coli, rpiR negatively regulates the expression of rpiB gene. Both rpiB and rpiA are ribose phosphate...; Region: SIS_RpiR; cd05013 755731006123 putative active site [active] 755731006124 oxaloacetate decarboxylase; Provisional; Region: PRK12331 755731006125 Pyruvate carboxylase and Transcarboxylase 5S, carboxyltransferase domain; Region: DRE_TIM_PC_TC_5S; cd07937 755731006126 active site 755731006127 catalytic residues [active] 755731006128 metal binding site [ion binding]; metal-binding site 755731006129 homodimer binding site [polypeptide binding]; other site 755731006130 acetyl-CoA carboxylase biotin carboxyl carrier protein subunit; Validated; Region: PRK06549 755731006131 The biotinyl-domain or biotin carboxyl carrier protein (BCCP) domain is present in all biotin-dependent enzymes, such as acetyl-CoA carboxylase, pyruvate carboxylase, propionyl-CoA carboxylase, methylcrotonyl-CoA carboxylase, geranyl-CoA carboxylase; Region: biotinyl_domain; cd06850 755731006132 carboxyltransferase (CT) interaction site; other site 755731006133 biotinylation site [posttranslational modification]; other site 755731006134 methylmalonyl-CoA decarboxylase alpha subunit; Region: mmdA; TIGR01117 755731006135 malonate decarboxylase subunit beta; Reviewed; Region: PRK07189; cl17682 755731006136 Acetyl-CoA carboxylase alpha subunit [Lipid metabolism]; Region: AccA; cl17345 755731006137 putative RNA polymerase sigma factor SigI; Reviewed; Region: PRK08311 755731006138 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 755731006139 Anti-sigma factor N-terminus; Region: RsgI_N; pfam12791 755731006140 Putative rRNA methylase; Region: rRNA_methylase; pfam06962 755731006141 16S rRNA uridine-516 pseudouridylate synthase and related pseudouridylate synthases [Translation, ribosomal structure and biogenesis]; Region: RsuA; COG1187 755731006142 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 755731006143 RNA binding surface [nucleotide binding]; other site 755731006144 Pseudouridine synthases, RsuA subfamily; Region: PseudoU_synth_RsuA_like; cd02870 755731006145 active site 755731006146 Sporulation protein YtfJ (Spore_YtfJ); Region: Spore_YtfJ; cl01596 755731006147 Protein of unknown function (DUF2953); Region: DUF2953; pfam11167 755731006148 Putative transcriptional regulators (Ypuh-like); Region: DUF387; pfam04079 755731006149 ScpA/B protein; Region: ScpA_ScpB; cl00598 755731006150 Uncharacterized homologs of Site-2 protease (S2P), zinc metalloproteases (MEROPS family M50) which cleave transmembrane domains of substrate proteins, regulating intramembrane proteolysis (RIP) of diverse signal transduction mechanisms. Members of the...; Region: S2P-M50_like_1; cd06158 755731006151 Peptidase family M50; Region: Peptidase_M50; pfam02163 755731006152 active site 755731006153 putative substrate binding region [chemical binding]; other site 755731006154 Beta-lactamase enzyme family; Region: Beta-lactamase2; cl17872 755731006155 D-alanyl-D-alanine carboxypeptidase [Cell envelope biogenesis, outer membrane]; Region: DacC; COG1686 755731006156 Penicillin-binding protein 5, C-terminal domain; Region: PBP5_C; smart00936 755731006157 pyrimidine-nucleoside phosphorylase; Region: Y_phosphoryl; TIGR02644 755731006158 Glycosyl transferase family, helical bundle domain; Region: Glycos_trans_3N; pfam02885 755731006159 Glycosyl transferase family, a/b domain; Region: Glycos_transf_3; pfam00591 755731006160 Pyrimidine nucleoside phosphorylase C-terminal domain; Region: PYNP_C; smart00941 755731006161 XerD and XerC integrases, DNA breaking-rejoining enzymes, N- and C-terminal domains. XerD-like integrases are involved in the site-specific integration and excision of lysogenic bacteriophage genomes, transposition of conjugative transposons, termination...; Region: INT_XerDC; cd00798 755731006162 tyrosine recombinase XerD; Region: recomb_XerD; TIGR02225 755731006163 active site 755731006164 Int/Topo IB signature motif; other site 755731006165 Integral membrane protein DUF95; Region: DUF95; cl00572 755731006166 adenosine nucleotide hydrolase NudE; Provisional; Region: nudE; PRK11762 755731006167 ADP-ribose pyrophosphatase (ADPRase) catalyzes the hydrolysis of ADP-ribose and a variety of additional ADP-sugar conjugates to AMP and ribose-5-phosphate. Like other members of the Nudix hydrolase superfamily, it requires a divalent cation, such as Mg2+; Region: ADPRase_NUDT5; cd03424 755731006168 dimer interface [polypeptide binding]; other site 755731006169 ADP-ribose binding site [chemical binding]; other site 755731006170 active site 755731006171 nudix motif; other site 755731006172 metal binding site [ion binding]; metal-binding site 755731006173 RNase HI family found mainly in prokaryotes; Region: RNase_HI_prokaryote_like; cd09278 755731006174 RNA/DNA hybrid binding site [nucleotide binding]; other site 755731006175 active site 755731006176 pyrroline-5-carboxylate reductase; Reviewed; Region: PRK11880 755731006177 pyrroline-5-carboxylate reductase; Region: PLN02688 755731006178 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 755731006179 phenylacetate-CoA ligase; Region: PA_CoA_ligase; TIGR02155 755731006180 acyl-activating enzyme (AAE) consensus motif; other site 755731006181 AMP binding site [chemical binding]; other site 755731006182 active site 755731006183 CoA binding site [chemical binding]; other site 755731006184 L-lactate permease [Energy production and conversion]; Region: LldP; COG1620 755731006185 L-lactate permease; Region: Lactate_perm; cl00701 755731006186 Predicted exonuclease of the beta-lactamase fold involved in RNA processing [Translation, ribosomal structure and biogenesis]; Region: YSH1; COG1236 755731006187 Metallo-beta-lactamase superfamily; Region: Lactamase_B; smart00849 755731006188 Beta-Casp domain; Region: Beta-Casp; smart01027 755731006189 RNA-metabolising metallo-beta-lactamase; Region: RMMBL; pfam07521 755731006190 Cellulase M and related proteins [Carbohydrate transport and metabolism]; Region: FrvX; COG1363 755731006191 M42 Peptidase, Endoglucanases; Region: M42_Frv; cd05656 755731006192 oligomer interface [polypeptide binding]; other site 755731006193 active site 755731006194 metal binding site [ion binding]; metal-binding site 755731006195 Cellulase M and related proteins [Carbohydrate transport and metabolism]; Region: FrvX; COG1363 755731006196 M42 Peptidase, Endoglucanases; Region: M42_Frv; cd05656 755731006197 oligomer interface [polypeptide binding]; other site 755731006198 active site 755731006199 metal binding site [ion binding]; metal-binding site 755731006200 M42 Peptidase, Endoglucanases; Region: M42_Frv; cd05656 755731006201 oligomer interface [polypeptide binding]; other site 755731006202 Cellulase M and related proteins [Carbohydrate transport and metabolism]; Region: FrvX; COG1363 755731006203 active site 755731006204 metal binding site [ion binding]; metal-binding site 755731006205 dipeptide transporter ATP-binding subunit; Provisional; Region: dppF; PRK11308 755731006206 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 755731006207 Walker A/P-loop; other site 755731006208 ATP binding site [chemical binding]; other site 755731006209 Q-loop/lid; other site 755731006210 ABC transporter signature motif; other site 755731006211 Walker B; other site 755731006212 D-loop; other site 755731006213 H-loop/switch region; other site 755731006214 oligopeptide/dipeptide ABC transporter, ATP-binding protein, C-terminal domain; Region: oligo_HPY; TIGR01727 755731006215 ABC-type dipeptide/oligopeptide/nickel transport system, ATPase component [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppD; COG0444 755731006216 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 755731006217 Walker A/P-loop; other site 755731006218 ATP binding site [chemical binding]; other site 755731006219 Q-loop/lid; other site 755731006220 ABC transporter signature motif; other site 755731006221 Walker B; other site 755731006222 D-loop; other site 755731006223 H-loop/switch region; other site 755731006224 oligopeptide/dipeptide ABC transporter, ATP-binding protein, C-terminal domain; Region: oligo_HPY; TIGR01727 755731006225 N-terminal TM domain of oligopeptide transport permease C; Region: OppC_N; pfam12911 755731006226 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppC; COG1173 755731006227 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 755731006228 dimer interface [polypeptide binding]; other site 755731006229 conserved gate region; other site 755731006230 putative PBP binding loops; other site 755731006231 ABC-ATPase subunit interface; other site 755731006232 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppB; COG0601 755731006233 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 755731006234 dimer interface [polypeptide binding]; other site 755731006235 conserved gate region; other site 755731006236 putative PBP binding loops; other site 755731006237 ABC-ATPase subunit interface; other site 755731006238 ABC-type dipeptide transport system, periplasmic component [Amino acid transport and metabolism]; Region: DdpA; COG0747 755731006239 The substrate-binding domain of an ABC-type nickel/oligopeptide-like import system contains the type 2 periplasmic binding fold; Region: PBP2_NikA_DppA_OppA_like; cd00995 755731006240 ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132 755731006241 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 755731006242 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 755731006243 Walker A/P-loop; other site 755731006244 ATP binding site [chemical binding]; other site 755731006245 Q-loop/lid; other site 755731006246 ABC transporter signature motif; other site 755731006247 Walker B; other site 755731006248 D-loop; other site 755731006249 H-loop/switch region; other site 755731006250 ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132 755731006251 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 755731006252 ATP-binding cassette domain of glucan transporter and related proteins, subfamily C; Region: ABCC_Glucan_exporter_like; cd03254 755731006253 Walker A/P-loop; other site 755731006254 ATP binding site [chemical binding]; other site 755731006255 Q-loop/lid; other site 755731006256 ABC transporter signature motif; other site 755731006257 Walker B; other site 755731006258 D-loop; other site 755731006259 H-loop/switch region; other site 755731006260 hypothetical protein; Provisional; Region: PRK13670 755731006261 HIGH Nucleotidyl Transferase; Region: HIGH_NTase1; cl17673 755731006262 mRNA degradation ribonucleases J1/J2 (metallo-beta-lactamase superfamily) [Translation, ribosomal structure and biogenesis; Replication, recombination and repair]; Region: COG0595 755731006263 Metallo-beta-lactamase superfamily; Region: Lactamase_B; smart00849 755731006264 RNA-metabolising metallo-beta-lactamase; Region: RMMBL; pfam07521 755731006265 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 755731006266 This family is most closely related to the GT1 family of glycosyltransferases and named after YqgM in Bacillus licheniformis about which little is known. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to...; Region: GT1_YqgM_like; cd03801 755731006267 helicase-exonuclease AddAB, AddA subunit, Firmicutes type; Region: addA_Gpos; TIGR02785 755731006268 Family description; Region: UvrD_C_2; pfam13538 755731006269 PD-(D/E)XK nuclease superfamily; Region: PDDEXK_1; pfam12705 755731006270 helicase-exonuclease AddAB, AddB subunit; Region: addB_Gpos; TIGR02773 755731006271 PD-(D/E)XK nuclease superfamily; Region: PDDEXK_1; pfam12705 755731006272 CAAX protease self-immunity; Region: Abi; pfam02517 755731006273 CoA binding domain; Region: CoA_binding_2; pfam13380 755731006274 Flavin containing amine oxidoreductase; Region: Amino_oxidase; pfam01593 755731006275 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450 755731006276 thioredoxin-disulfide reductase; Region: TRX_reduct; TIGR01292 755731006277 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500 755731006278 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 755731006279 FOG: CBS domain [General function prediction only]; Region: COG0517 755731006280 The CBS domain, named after human CBS, is a small domain originally identified in cystathionine beta-synthase and is subsequently found in a wide range of different proteins. CBS domains usually occur in tandem repeats. They associate to form a so-called...; Region: CBS_pair_9; cd04622 755731006281 Predicted transcriptional regulators [Transcription]; Region: SoxR; COG0789 755731006282 Helix-Turn-Helix DNA binding domain of the transcription regulators TipAL, Mta, and SkgA; Region: HTH_TipAL-Mta; cd01106 755731006283 DNA binding residues [nucleotide binding] 755731006284 dimer interface [polypeptide binding]; other site 755731006285 TipAS antibiotic-recognition domain; Region: TipAS; pfam07739 755731006286 Ferritin-like superfamily of diiron-containing four-helix-bundle proteins; Region: Ferritin_like; cd00657 755731006287 dinuclear metal binding motif [ion binding]; other site 755731006288 Bacillus/Clostridium GerA spore germination protein; Region: GerA; pfam03323 755731006289 germination protein, Ger(x)C family; Region: spore_ger_x_C; TIGR02887 755731006290 Spore germination B3/ GerAC like, C-terminal; Region: Spore_GerAC; pfam05504 755731006291 Spore germination protein; Region: Spore_permease; cl17796 755731006292 L,D-transpeptidase catalytic domain; Region: YkuD; pfam03734 755731006293 Uncharacterized protein conserved in bacteria [Function unknown]; Region: ErfK; COG1376 755731006294 Putative peptidoglycan binding domain; Region: PG_binding_1; pfam01471 755731006295 Aspartate alpha-decarboxylase or L-aspartate 1-decarboxylase, a pyruvoyl group-dependent decarboxylase in beta-alanine production; Region: Asp_decarbox; cd06919 755731006296 tetramerization interface [polypeptide binding]; other site 755731006297 active site 755731006298 Pantoate-beta-alanine ligase; Region: PanC; cd00560 755731006299 pantoate--beta-alanine ligase; Region: panC; TIGR00018 755731006300 active site 755731006301 ATP-binding site [chemical binding]; other site 755731006302 pantoate-binding site; other site 755731006303 HXXH motif; other site 755731006304 Ketopantoate hydroxymethyltransferase (KPHMT) is the first enzyme in the pantothenate biosynthesis pathway. Ketopantoate hydroxymethyltransferase (KPHMT) catalyzes the first committed step in the biosynthesis of pantothenate (vitamin B5), which is a...; Region: KPHMT-like; cd06557 755731006305 oligomerization interface [polypeptide binding]; other site 755731006306 active site 755731006307 metal binding site [ion binding]; metal-binding site 755731006308 Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408 755731006309 Domain of unknown function (DUF2520); Region: DUF2520; pfam10728 755731006310 drug resistance transporter, EmrB/QacA subfamily; Region: efflux_EmrB; TIGR00711 755731006311 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 755731006312 putative substrate translocation pore; other site 755731006313 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 755731006314 Predicted transcriptional regulators [Transcription]; Region: COG1695 755731006315 Transcriptional regulator PadR-like family; Region: PadR; pfam03551 755731006316 Virulence activator alpha C-term; Region: Vir_act_alpha_C; pfam10400 755731006317 glycyl-tRNA synthetase; Provisional; Region: PRK04173 755731006318 Class II tRNA amino-acyl synthetase-like catalytic core domain. Class II amino acyl-tRNA synthetases (aaRS) share a common fold and generally attach an amino acid to the 3' OH of ribose of the appropriate tRNA. PheRS is an exception in that it...; Region: class_II_aaRS-like_core; cl00268 755731006319 motif 1; other site 755731006320 Glycyl-tRNA synthetase (GlyRS)-like class II core catalytic domain. GlyRS functions as a homodimer in eukaryotes, archaea and some bacteria and as a heterotetramer in the remainder of prokaryotes. It is responsible for the attachment of glycine to the 3...; Region: GlyRS-like_core; cd00774 755731006321 active site 755731006322 motif 2; other site 755731006323 motif 3; other site 755731006324 GlyRS Glycyl-anticodon binding domain. GlyRS belongs to class II aminoacyl-tRNA synthetases (aaRS). This alignment contains the anticodon binding domain, which is responsible for specificity in tRNA-binding, so that the activated amino acid is...; Region: GlyRS_anticodon; cd00858 755731006325 anticodon binding site; other site 755731006326 DNA-directed RNA polymerase subunit omega; Reviewed; Region: rpoZ; PRK00392 755731006327 Guanylate kinase [Nucleotide transport and metabolism]; Region: Gmk; COG0194 755731006328 Guanosine monophosphate kinase (GMPK, EC 2.7.4.8), also known as guanylate kinase (GKase), catalyzes the reversible phosphoryl transfer from adenosine triphosphate (ATP) to guanosine monophosphate (GMP) to yield adenosine diphosphate (ADP) and guanosine...; Region: GMPK; cd00071 755731006329 catalytic site [active] 755731006330 G-X2-G-X-G-K; other site 755731006331 hypothetical protein; Provisional; Region: PRK04323 755731006332 hypothetical protein; Provisional; Region: PRK11820 755731006333 YicC-like family, N-terminal region; Region: YicC_N; pfam03755 755731006334 Domain of unknown function (DUF1732); Region: DUF1732; pfam08340 755731006335 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 755731006336 Response regulator receiver domain; Region: Response_reg; pfam00072 755731006337 active site 755731006338 phosphorylation site [posttranslational modification] 755731006339 intermolecular recognition site; other site 755731006340 dimerization interface [polypeptide binding]; other site 755731006341 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG1385 755731006342 RNA methyltransferase, RsmE family; Region: TIGR00046 755731006343 ribosomal protein L11 methyltransferase; Reviewed; Region: prmA; PRK00517 755731006344 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 755731006345 S-adenosylmethionine binding site [chemical binding]; other site 755731006346 chaperone protein DnaJ; Provisional; Region: PRK14277 755731006347 DnaJ domain or J-domain. DnaJ/Hsp40 (heat shock protein 40) proteins are highly conserved and play crucial roles in protein translation, folding, unfolding, translocation, and degradation. They act primarily by stimulating the ATPase activity of Hsp70s; Region: DnaJ; cd06257 755731006348 HSP70 interaction site [polypeptide binding]; other site 755731006349 C-terminal substrate binding domain of DnaJ and HSP40; Region: DnaJ_C; cl03262 755731006350 substrate binding site [polypeptide binding]; other site 755731006351 Zinc finger domain of DnaJ and HSP40; Region: DnaJ_zf; cd10719 755731006352 Zn binding sites [ion binding]; other site 755731006353 C-terminal substrate binding domain of DnaJ and HSP40; Region: DnaJ_C; cd10747 755731006354 dimer interface [polypeptide binding]; other site 755731006355 molecular chaperone DnaK; Provisional; Region: dnaK; PRK00290 755731006356 Nucleotide-binding domain of human HSPA9 and similar proteins; Region: HSPA9-Ssq1-like_NBD; cd10234 755731006357 nucleotide binding site [chemical binding]; other site 755731006358 NEF interaction site [polypeptide binding]; other site 755731006359 SBD interface [polypeptide binding]; other site 755731006360 GrpE; Region: GrpE; pfam01025 755731006361 GrpE is the adenine nucleotide exchange factor of DnaK (Hsp70)-type ATPases. The GrpE dimer binds to the ATPase domain of Hsp70 catalyzing the dissociation of ADP, which enables rebinding of ATP, one step in the Hsp70 reaction cycle in protein folding; Region: GrpE; cd00446 755731006362 dimer interface [polypeptide binding]; other site 755731006363 hsp70 (ATPase domain) interactions [polypeptide binding]; other site 755731006364 heat-inducible transcription repressor; Provisional; Region: hrcA; PRK00082 755731006365 Winged helix-turn-helix transcription repressor, HrcA DNA-binding; Region: HrcA_DNA-bdg; pfam03444 755731006366 PyridoxaL 5'-Phosphate Dependent Enzymes class IV (PLPDE_IV). This D-amino acid superfamily, one of five classes of PLPDE, consists of branched-chain amino acid aminotransferases (BCAT), D-amino acid transferases (DAAT), and...; Region: PLPDE_IV; cd00449 755731006367 Branched-chain amino acid aminotransferase/4-amino-4-deoxychorismate lyase [Amino acid transport and metabolism / Coenzyme metabolism]; Region: IlvE; COG0115 755731006368 homodimer interface [polypeptide binding]; other site 755731006369 substrate-cofactor binding pocket; other site 755731006370 pyridoxal 5'-phosphate binding site [chemical binding]; other site 755731006371 catalytic residue [active] 755731006372 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 755731006373 Zn2+ binding site [ion binding]; other site 755731006374 Mg2+ binding site [ion binding]; other site 755731006375 deoxyguanosinetriphosphate triphosphohydrolase-like protein; Provisional; Region: PRK01286 755731006376 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 755731006377 Zn2+ binding site [ion binding]; other site 755731006378 Mg2+ binding site [ion binding]; other site 755731006379 Phosphohydrolase-associated domain; Region: HD_assoc; pfam13286 755731006380 Uncharacterized distant relative of cell wall-associated hydrolases [Function unknown]; Region: COG3863 755731006381 ABC-type cobalt transport system, permease component CbiQ and related transporters [Inorganic ion transport and metabolism]; Region: CbiQ; COG0619 755731006382 ABC-type cobalt transport system, ATPase component [Inorganic ion transport and metabolism]; Region: CbiO; COG1122 755731006383 First domain of the ATP-binding cassette component of cobalt transport system; Region: ABC_cobalt_CbiO_domain1; cd03225 755731006384 Walker A/P-loop; other site 755731006385 ATP binding site [chemical binding]; other site 755731006386 Q-loop/lid; other site 755731006387 ABC transporter signature motif; other site 755731006388 Walker B; other site 755731006389 D-loop; other site 755731006390 H-loop/switch region; other site 755731006391 ABC-type cobalt transport system, ATPase component [Inorganic ion transport and metabolism]; Region: CbiO; COG1122 755731006392 First domain of the ATP-binding cassette component of cobalt transport system; Region: ABC_cobalt_CbiO_domain1; cd03225 755731006393 Walker A/P-loop; other site 755731006394 ATP binding site [chemical binding]; other site 755731006395 Q-loop/lid; other site 755731006396 ABC transporter signature motif; other site 755731006397 Walker B; other site 755731006398 D-loop; other site 755731006399 H-loop/switch region; other site 755731006400 Sulfatase; Region: Sulfatase; cl17466 755731006401 integrating conjugative element relaxase, PFL_4751 family; Region: ICE_TraI_Pfluor; TIGR03760 755731006402 Chagasin family peptidase inhibitor I42; Region: Inhibitor_I42; pfam09394 755731006403 Chagasin family peptidase inhibitor I42; Region: Inhibitor_I42; pfam09394 755731006404 Chagasin family peptidase inhibitor I42; Region: Inhibitor_I42; pfam09394 755731006405 Chagasin family peptidase inhibitor I42; Region: Inhibitor_I42; pfam09394 755731006406 Predicted glycosyltransferases [General function prediction only]; Region: COG1216 755731006407 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cd00761 755731006408 active site 755731006409 Exonuclease-Endonuclease-Phosphatase (EEP) domain superfamily; Region: EEP; cl00490 755731006410 putative catalytic site [active] 755731006411 putative metal binding site [ion binding]; other site 755731006412 putative phosphate binding site [ion binding]; other site 755731006413 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394 755731006414 active site 755731006415 Ornithine/acetylornithine aminotransferase [Amino acid transport and metabolism]; Region: ArgD; COG4992 755731006416 Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610 755731006417 inhibitor-cofactor binding pocket; inhibition site 755731006418 pyridoxal 5'-phosphate binding site [chemical binding]; other site 755731006419 catalytic residue [active] 755731006420 Nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: WcaG; COG0451 755731006421 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 755731006422 NAD(P) binding site [chemical binding]; other site 755731006423 active site 755731006424 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cd00761 755731006425 active site 755731006426 Glycosyl transferase family 21; Region: Glyco_transf_21; pfam13506 755731006427 Membrane protein involved in the export of O-antigen and teichoic acid [General function prediction only]; Region: RfbX; COG2244 755731006428 Multidrug and toxic compound extrusion family and similar proteins; Region: MATE_like; cl09326 755731006429 phosphoribose diphosphate:decaprenyl-phosphate phosphoribosyltransferase; Provisional; Region: PRK12324 755731006430 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 755731006431 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 755731006432 DNA binding residues [nucleotide binding] 755731006433 dimerization interface [polypeptide binding]; other site 755731006434 LexA regulated protein; Provisional; Region: PRK11675 755731006435 Helix-turn-helix domain; Region: HTH_17; cl17695 755731006436 Helix-turn-helix domain; Region: HTH_17; cl17695 755731006437 Breast Cancer Suppressor Protein (BRCA1), carboxy-terminal domain. The BRCT domain is found within many DNA damage repair and cell cycle checkpoint proteins. The unique diversity of this domain superfamily allows BRCT modules to interact forming homo...; Region: BRCT; cd00027 755731006438 Dimer interface [polypeptide binding]; other site 755731006439 The Ntn hydrolases (N-terminal nucleophile) are a diverse superfamily of of enzymes that are activated autocatalytically via an N-terminally lcated nucleophilic amino acid. N-terminal nucleophile (NTN-) hydrolase superfamily, which contains a...; Region: Ntn_hydrolase; cl00467 755731006440 active site 755731006441 RNA polymerase sigma factor, sigma-70 family; Region: sigma70-ECF; TIGR02937 755731006442 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 755731006443 Helix-turn-helix domain; Region: HTH_36; pfam13730 755731006444 Helix-turn-helix domain; Region: HTH_17; cl17695 755731006445 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 755731006446 non-specific DNA binding site [nucleotide binding]; other site 755731006447 salt bridge; other site 755731006448 sequence-specific DNA binding site [nucleotide binding]; other site 755731006449 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 755731006450 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 755731006451 non-specific DNA binding site [nucleotide binding]; other site 755731006452 salt bridge; other site 755731006453 sequence-specific DNA binding site [nucleotide binding]; other site 755731006454 Integrase [DNA replication, recombination, and repair]; Region: XerC; COG0582 755731006455 phiLC3 phage and phage-related integrases, site-specific recombinases, DNA breaking-rejoining enzymes, C-terminal catalytic domain. This CD includes various bacterial (mainly gram positive) and phage integrases, including those similar to Lactococcus...; Region: INT_phiLC3_C; cd01189 755731006456 Int/Topo IB signature motif; other site 755731006457 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 755731006458 haloacid dehalogenase-like hydrolase; Region: Hydrolase_3; pfam08282 755731006459 active site 755731006460 motif I; other site 755731006461 motif II; other site 755731006462 haloacid dehalogenase-like hydrolase; Region: HAD; cl17202 755731006463 Prokaryotic dksA/traR C4-type zinc finger; Region: zf-dskA_traR; cl00755 755731006464 Dehydroquinate synthase (DHQS) catalyzes the conversion of DAHP to DHQ in shikimate pathway for aromatic compounds synthesis; Region: DHQS; cd08195 755731006465 active site 755731006466 dimer interface [polypeptide binding]; other site 755731006467 metal binding site [ion binding]; metal-binding site 755731006468 isoleucyl-tRNA synthetase; Reviewed; Region: ileS; PRK05743 755731006469 catalytic core domain of isoleucyl-tRNA synthetases; Region: IleRS_core; cd00818 755731006470 HIGH motif; other site 755731006471 Leucyl-tRNA synthetase, Domain 2; Region: tRNA-synt_1_2; pfam13603 755731006472 catalytic core domain of isoleucyl-tRNA synthetases; Region: IleRS_core; cd00818 755731006473 active site 755731006474 KMSKS motif; other site 755731006475 Anticodon-binding domain of bacterial and eukaryotic mitochondrial isoleucyl tRNA synthetases; Region: Anticodon_Ia_Ile_BEm; cd07960 755731006476 tRNA binding surface [nucleotide binding]; other site 755731006477 anticodon binding site; other site 755731006478 Zinc finger found in FPG and IleRS; Region: zf-FPG_IleRS; pfam06827 755731006479 Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain (MocR family) and their eukaryotic orthologs [Transcription / Amino acid transport and metabolism]; Region: ARO8; COG1167 755731006480 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 755731006481 DNA-binding site [nucleotide binding]; DNA binding site 755731006482 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 755731006483 pyridoxal 5'-phosphate binding site [chemical binding]; other site 755731006484 homodimer interface [polypeptide binding]; other site 755731006485 catalytic residue [active] 755731006486 pyridoxal 5'-phosphate synthase, synthase subunit Pdx1; Region: TIGR00343 755731006487 PdxS is a subunit of the pyridoxal 5'-phosphate (PLP) synthase, an important enzyme in deoxyxylulose 5-phosphate (DXP)-independent pathway for de novo biosynthesis of PLP, present in some eubacteria, in archaea, fungi, plants, plasmodia, and some...; Region: pdxS; cd04727 755731006488 active site 755731006489 multimer interface [polypeptide binding]; other site 755731006490 Glutamine Amidotransferase (GATase_I) involved in pyridoxine biosynthesis; Region: GATase1_PB; cd01749 755731006491 predicted active site [active] 755731006492 catalytic triad [active] 755731006493 Rhomboid family; Region: Rhomboid; pfam01694 755731006494 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 755731006495 TPR motif; other site 755731006496 binding surface 755731006497 Tetratricopeptide repeat; Region: TPR_16; pfam13432 755731006498 Methionine synthase I (cobalamin-dependent), methyltransferase domain [Amino acid transport and metabolism]; Region: MetH; cl14105 755731006499 Homocysteine S-methyltransferase; Region: S-methyl_trans; pfam02574 755731006500 Pterin binding enzymes. This family includes dihydropteroate synthase (DHPS) and cobalamin-dependent methyltransferases such as methyltetrahydrofolate, corrinoid iron-sulfur protein methyltransferase (MeTr) and methionine synthase (MetH). DHPS, a...; Region: Pterin_binding; cl00219 755731006501 AMP-binding domain protein; Validated; Region: PRK08315 755731006502 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 755731006503 Uncharacterized subfamily of fatty acid CoA ligase (FACL); Region: FACL_like_2; cd05917 755731006504 acyl-activating enzyme (AAE) consensus motif; other site 755731006505 putative AMP binding site [chemical binding]; other site 755731006506 putative active site [active] 755731006507 putative CoA binding site [chemical binding]; other site 755731006508 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 755731006509 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 755731006510 active site 755731006511 phosphorylation site [posttranslational modification] 755731006512 intermolecular recognition site; other site 755731006513 dimerization interface [polypeptide binding]; other site 755731006514 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 755731006515 DNA binding residues [nucleotide binding] 755731006516 dimerization interface [polypeptide binding]; other site 755731006517 Sensor protein DegS; Region: DegS; pfam05384 755731006518 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: COG4585 755731006519 Histidine kinase; Region: HisKA_3; pfam07730 755731006520 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 755731006521 ATP binding site [chemical binding]; other site 755731006522 Mg2+ binding site [ion binding]; other site 755731006523 G-X-G motif; other site 755731006524 Uncharacterized conserved protein [Function unknown]; Region: COG1262 755731006525 Formylglycine-generating sulfatase enzyme; Region: FGE-sulfatase; pfam03781 755731006526 Glycosyl hydrolases family 11; Region: Glyco_hydro_11; pfam00457 755731006527 The GIY-YIG domain of uncharacterized protein family UPF0213 related to structure-specific endonuclease SLX1; Region: GIY-YIG_UPF0213; cd10456 755731006528 GIY-YIG motif/motif A; other site 755731006529 putative active site [active] 755731006530 putative metal binding site [ion binding]; other site 755731006531 Kynurenine formamidase [Amino acid transport and metabolism]; Region: COG1878 755731006532 Rubrerythrin [Energy production and conversion]; Region: COG1592 755731006533 Rubrerythrin, ferritin-like diiron-binding domain; Region: Rubrerythrin; cd01041 755731006534 binuclear metal center [ion binding]; other site 755731006535 Rubredoxin, Small Modular nonheme iron binding domain containing a [Fe(SCys)4] center, present in rubrerythrin and nigerythrin and detected either N- or C-terminal to such proteins as flavin reductase, NAD(P)H-nitrite reductase, and...; Region: rubredoxin_SM; cd00729 755731006536 iron binding site [ion binding]; other site 755731006537 Brown fat-inducible thioesterase (BFIT). Brain acyl-CoA hydrolase (BACH). These enzymes deacylate long-chain fatty acids by hydrolyzing acyl-CoA thioesters to free fatty acids and CoA-SH. Eukaryotic members of this family are expressed in brain, testis; Region: BFIT_BACH; cd03442 755731006538 Predicted ATPase [General function prediction only]; Region: COG3910 755731006539 ATP-binding cassette domain of non-transporter proteins; Region: ABC_Class2; cd03227 755731006540 Walker A/P-loop; other site 755731006541 ATP binding site [chemical binding]; other site 755731006542 Q-loop/lid; other site 755731006543 ABC transporter signature motif; other site 755731006544 Walker B; other site 755731006545 D-loop; other site 755731006546 H-loop/switch region; other site 755731006547 NAD-dependent deacetylase; Provisional; Region: PRK00481 755731006548 SIR2 superfamily of proteins includes silent information regulator 2 (Sir2) enzymes which catalyze NAD+-dependent protein/histone deacetylation, where the acetyl group from the lysine epsilon-amino group is transferred to the ADP-ribose moiety of NAD+; Region: SIR2; cl00195 755731006549 Integral membrane protein possibly involved in chromosome condensation [Cell division and chromosome partitioning]; Region: CrcB; COG0239 755731006550 Selenocysteine lyase/Cysteine desulfurase [Posttranslational modification, protein turnover, chaperones]; Region: csdA; COG0520 755731006551 Cysteine desulfurase (SufS)-like. This family belongs to the pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to cysteine desulfurase (SufS) and selenocysteine lyase. SufS...; Region: SufS_like; cd06453 755731006552 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 755731006553 catalytic residue [active] 755731006554 Aspartate/tyrosine/aromatic aminotransferase [Amino acid transport and metabolism]; Region: COG0436 755731006555 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 755731006556 pyridoxal 5'-phosphate binding site [chemical binding]; other site 755731006557 homodimer interface [polypeptide binding]; other site 755731006558 catalytic residue [active] 755731006559 Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain (MocR family) and their eukaryotic orthologs [Transcription / Amino acid transport and metabolism]; Region: ARO8; COG1167 755731006560 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 755731006561 DNA-binding site [nucleotide binding]; DNA binding site 755731006562 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 755731006563 pyridoxal 5'-phosphate binding site [chemical binding]; other site 755731006564 homodimer interface [polypeptide binding]; other site 755731006565 catalytic residue [active] 755731006566 branched-chain amino acid aminotransferase; Provisional; Region: PRK13357 755731006567 BCAT_beta_family: Branched-chain aminotransferase catalyses the transamination of the branched-chain amino acids leusine, isoleucine and valine to their respective alpha-keto acids, alpha-ketoisocaproate, alpha-keto-beta-methylvalerate and...; Region: BCAT_beta_family; cd01557 755731006568 homodimer interface [polypeptide binding]; other site 755731006569 substrate-cofactor binding pocket; other site 755731006570 catalytic residue [active] 755731006571 sporulation integral membrane protein YlbJ; Region: spore_ylbJ; TIGR02871 755731006572 Nucleoside recognition; Region: Gate; pfam07670 755731006573 TRAP-type mannitol/chloroaromatic compound transport system, periplasmic component [Secondary metabolites biosynthesis, transport, and catabolism]; Region: FcbT1; COG4663 755731006574 phosphopantetheine adenylyltransferase; Provisional; Region: coaD; PRK00168 755731006575 Phosphopantetheine adenylyltransferase; Region: PPAT; cd02163 755731006576 active site 755731006577 (T/H)XGH motif; other site 755731006578 Conserved hypothetical protein 95; Region: Cons_hypoth95; pfam03602 755731006579 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 755731006580 S-adenosylmethionine binding site [chemical binding]; other site 755731006581 ATP-dependent DNA helicase RecG; Provisional; Region: PRK10917 755731006582 RecG_wedge_OBF: A subfamily of OB folds corresponding to the OB fold found in the N-terminal (wedge) domain of Escherichia coli RecG. RecG is a branched-DNA-specific helicase, which catalyzes the interconversion of a DNA replication fork to a...; Region: RecG_wedge_OBF; cd04488 755731006583 ssDNA binding site; other site 755731006584 generic binding surface II; other site 755731006585 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 755731006586 ATP binding site [chemical binding]; other site 755731006587 putative Mg++ binding site [ion binding]; other site 755731006588 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 755731006589 nucleotide binding region [chemical binding]; other site 755731006590 ATP-binding site [chemical binding]; other site 755731006591 50S ribosomal protein L28; Reviewed; Region: rpmB; PRK00359 755731006592 FOG: GAF domain [Signal transduction mechanisms]; Region: FhlA; COG2203 755731006593 GAF domain; Region: GAF_3; pfam13492 755731006594 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 755731006595 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 755731006596 metal binding site [ion binding]; metal-binding site 755731006597 active site 755731006598 I-site; other site 755731006599 cell division protein FtsA; Region: ftsA; TIGR01174 755731006600 Cell division protein FtsA; Region: FtsA; smart00842 755731006601 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cl17037 755731006602 nucleotide binding site [chemical binding]; other site 755731006603 Sulfur transfer protein involved in thiamine biosynthesis [Coenzyme metabolism]; Region: ThiS; COG2104 755731006604 charged pocket; other site 755731006605 hydrophobic patch; other site 755731006606 Predicted EndoIII-related endonuclease [DNA replication, recombination, and repair]; Region: Nth; COG0177 755731006607 endonuclease III; includes endonuclease III (DNA-(apurinic or apyrimidinic site) lyase), alkylbase DNA glycosidases (Alka-family) and other DNA glycosidases; Region: ENDO3c; cd00056 755731006608 minor groove reading motif; other site 755731006609 helix-hairpin-helix signature motif; other site 755731006610 substrate binding pocket [chemical binding]; other site 755731006611 active site 755731006612 Iron-sulfur binding domain of endonuclease III; Region: EndIII_4Fe-2S; cl15304 755731006613 glycogen synthase; Provisional; Region: glgA; PRK00654 755731006614 This family is most closely related to the GT1 family of glycosyltransferases. Glycogen synthase catalyzes the formation and elongation of the alpha-1,4-glucose backbone using ADP-glucose, the second and key step of glycogen biosynthesis. This family...; Region: GT1_Glycogen_synthase_DULL1_like; cd03791 755731006615 ADP-binding pocket [chemical binding]; other site 755731006616 homodimer interface [polypeptide binding]; other site 755731006617 FOG: GAF domain [Signal transduction mechanisms]; Region: FhlA; COG2203 755731006618 GAF domain; Region: GAF_3; pfam13492 755731006619 c-di-GMP phosphodiesterase class II (HD-GYP domain) [Signal transduction mechanisms]; Region: COG2206 755731006620 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 755731006621 Zn2+ binding site [ion binding]; other site 755731006622 Mg2+ binding site [ion binding]; other site 755731006623 Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain [Posttranslational modification, protein turnover, chaperones]; Region: DegQ; COG0265 755731006624 Trypsin-like peptidase domain; Region: Trypsin_2; pfam13365 755731006625 PDZ domain of tryspin-like serine proteases, such as DegP/HtrA, which are oligomeric proteins involved in heat-shock response, chaperone function, and apoptosis. May be responsible for substrate recognition and/or binding, as most PDZ domains bind...; Region: PDZ_serine_protease; cd00987 755731006626 protein binding site [polypeptide binding]; other site 755731006627 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 755731006628 dimerization interface [polypeptide binding]; other site 755731006629 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 755731006630 dimer interface [polypeptide binding]; other site 755731006631 phosphorylation site [posttranslational modification] 755731006632 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 755731006633 ATP binding site [chemical binding]; other site 755731006634 Mg2+ binding site [ion binding]; other site 755731006635 G-X-G motif; other site 755731006636 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 755731006637 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 755731006638 active site 755731006639 phosphorylation site [posttranslational modification] 755731006640 intermolecular recognition site; other site 755731006641 dimerization interface [polypeptide binding]; other site 755731006642 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 755731006643 DNA binding site [nucleotide binding] 755731006644 sporulation transcription factor Spo0A; Region: spore_0_A; TIGR02875 755731006645 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 755731006646 active site 755731006647 phosphorylation site [posttranslational modification] 755731006648 intermolecular recognition site; other site 755731006649 dimerization interface [polypeptide binding]; other site 755731006650 Sporulation initiation factor Spo0A C terminal; Region: Spo0A_C; pfam08769 755731006651 stage IV sporulation protein B; Region: spore_IV_B; TIGR02860 755731006652 PDZ domain of tryspin-like serine proteases, such as DegP/HtrA, which are oligomeric proteins involved in heat-shock response, chaperone function, and apoptosis. May be responsible for substrate recognition and/or binding, as most PDZ domains bind...; Region: PDZ_serine_protease; cd00987 755731006653 SpoIVB peptidase S55; Region: Peptidase_S55; pfam05580 755731006654 ATPase involved in DNA repair [DNA replication, recombination, and repair]; Region: RecN; COG0497 755731006655 ATP-binding cassette domain of RecN; Region: ABC_RecN; cd03241 755731006656 Walker A/P-loop; other site 755731006657 ATP binding site [chemical binding]; other site 755731006658 Q-loop/lid; other site 755731006659 ATP-binding cassette domain of RecN; Region: ABC_RecN; cd03241 755731006660 ABC transporter signature motif; other site 755731006661 Walker B; other site 755731006662 D-loop; other site 755731006663 H-loop/switch region; other site 755731006664 arginine repressor; Provisional; Region: argR; PRK00441 755731006665 Arginine repressor, DNA binding domain; Region: Arg_repressor; pfam01316 755731006666 Arginine repressor, C-terminal domain; Region: Arg_repressor_C; pfam02863 755731006667 NAD kinase [Coenzyme metabolism]; Region: nadF; COG0061 755731006668 ATP-NAD kinase; Region: NAD_kinase; pfam01513 755731006669 Predicted rRNA methylase [Translation, ribosomal structure and biogenesis]; Region: COG1189 755731006670 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 755731006671 RNA binding surface [nucleotide binding]; other site 755731006672 FtsJ-like methyltransferase; Region: FtsJ; pfam01728 755731006673 1-deoxy-D-xylulose-5-phosphate synthase; Provisional; Region: PRK05444 755731006674 Thiamine pyrophosphate (TPP) family, DXS subfamily, TPP-binding module; 1-Deoxy-D-xylulose-5-phosphate synthase (DXS) is a regulatory enzyme of the mevalonate-independent pathway involved in terpenoid biosynthesis. Terpeniods are plant natural products...; Region: TPP_DXS; cd02007 755731006675 TPP-binding site; other site 755731006676 Pyrimidine (PYR) binding domain of 1-deoxy-D-xylulose-5-phosphate synthase (DXS), transketolase (TK), and related proteins; Region: TPP_PYR_DXS_TK_like; cd07033 755731006677 PYR/PP interface [polypeptide binding]; other site 755731006678 dimer interface [polypeptide binding]; other site 755731006679 TPP binding site [chemical binding]; other site 755731006680 Transketolase, C-terminal domain; Region: Transketolase_C; pfam02780 755731006681 Geranylgeranyl pyrophosphate synthase [Coenzyme metabolism]; Region: IspA; COG0142 755731006682 Trans-Isoprenyl Diphosphate Synthases, head-to-tail; Region: Trans_IPPS_HT; cd00685 755731006683 substrate binding pocket [chemical binding]; other site 755731006684 chain length determination region; other site 755731006685 substrate-Mg2+ binding site; other site 755731006686 catalytic residues [active] 755731006687 aspartate-rich region 1; other site 755731006688 active site lid residues [active] 755731006689 aspartate-rich region 2; other site 755731006690 exodeoxyribonuclease VII small subunit; Provisional; Region: PRK00977 755731006691 exodeoxyribonuclease VII large subunit; Reviewed; Region: xseA; PRK00286 755731006692 ExoVII_LU_OBF: A subfamily of OB folds corresponding to the N-terminal OB-fold domain of Escherichia coli exodeoxyribonuclease VII (ExoVII) large subunit. E. coli ExoVII is composed of two non-identical subunits. E. coli ExoVII is a...; Region: ExoVII_LU_OBF; cd04489 755731006693 generic binding surface II; other site 755731006694 generic binding surface I; other site 755731006695 transcription antitermination protein NusB; Reviewed; Region: nusB; PRK00202 755731006696 putative RNA binding site [nucleotide binding]; other site 755731006697 Asp23 family; Region: Asp23; pfam03780 755731006698 Asp23 family; Region: Asp23; pfam03780 755731006699 SpoIIIAH-like protein; Region: SpoIIIAH; pfam12685 755731006700 stage III sporulation protein AG; Region: spore_III_AG; TIGR02830 755731006701 Stage III sporulation protein AF (Spore_III_AF); Region: Spore_III_AF; pfam09581 755731006702 Stage III sporulation protein AE (spore_III_AE); Region: Spore_III_AE; pfam09546 755731006703 stage III sporulation protein AD; Region: spore_III_AD; TIGR02849 755731006704 stage III sporulation protein AC; Region: spore_III_AC; TIGR02848 755731006705 Stage III sporulation protein AB (spore_III_AB); Region: Spore_III_AB; pfam09548 755731006706 stage III sporulation protein AA; Region: spore_III_AA; TIGR02858 755731006707 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 755731006708 Walker A motif; other site 755731006709 ATP binding site [chemical binding]; other site 755731006710 Walker B motif; other site 755731006711 ABC-type Na+ transport system, ATPase component [Energy production and conversion / Inorganic ion transport and metabolism]; Region: NatA; COG4555 755731006712 ATP-binding cassette domain of the drug resistance transporter and related proteins, subfamily A; Region: ABC_DR_subfamily_A; cd03230 755731006713 Walker A/P-loop; other site 755731006714 ATP binding site [chemical binding]; other site 755731006715 Q-loop/lid; other site 755731006716 ABC transporter signature motif; other site 755731006717 Walker B; other site 755731006718 D-loop; other site 755731006719 H-loop/switch region; other site 755731006720 Predicted transcriptional regulators [Transcription]; Region: COG1725 755731006721 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 755731006722 DNA-binding site [nucleotide binding]; DNA binding site 755731006723 DNA directed RNA polymerase, 7 kDa subunit; Region: DNA_RNApol_7kD; cl00874 755731006724 elongation factor P; Validated; Region: PRK00529 755731006725 Elongation factor P (EF-P) KOW-like domain; Region: EFP_N; pfam08207 755731006726 S1_EF-P_repeat_1: Translation elongation factor P (EF-P), S1-like RNA-binding domain, repeat 1. EF-P stimulates the peptidyltransferase activity in the prokaryotic 70S ribosome. EF-P enhances the synthesis of certain dipeptides with...; Region: S1_EF-P_repeat_1; cd04470 755731006727 RNA binding site [nucleotide binding]; other site 755731006728 S1_EF-P_repeat_2: Translation elongation factor P (EF-P), S1-like RNA-binding domain, repeat 1. EF-P stimulates the peptidyltransferase activity in the prokaryotic 70S ribosome. EF-P enhances the synthesis of certain dipeptides with...; Region: S1_EF-P_repeat_2; cd05794 755731006729 RNA binding site [nucleotide binding]; other site 755731006730 Xaa-Pro aminopeptidase [Amino acid transport and metabolism]; Region: PepP; COG0006 755731006731 Creatinase/Prolidase N-terminal domain; Region: Creatinase_N; pfam01321 755731006732 Similar to Prolidase and Aminopeptidase P. The members of this subfamily presumably catalyse hydrolysis of Xaa-Pro dipeptides and/or release of any N-terminal amino acid, including proline, that is linked with proline; Region: APP-like; cd01092 755731006733 active site 755731006734 Dehydroquinase class II; Region: DHquinase_II; pfam01220 755731006735 Dehydroquinase (DHQase), type II. Dehydroquinase (or 3-dehydroquinate dehydratase) catalyzes the reversible dehydration of 3-dehydroquinate to form 3-dehydroshikimate. This reaction is part of two metabolic pathways: the biosynthetic shikimate pathway...; Region: DHQase_II; cd00466 755731006736 trimer interface [polypeptide binding]; other site 755731006737 active site 755731006738 dimer interface [polypeptide binding]; other site 755731006739 Endonuclease IV [DNA replication, recombination, and repair]; Region: Nfo; COG0648 755731006740 AP endonuclease family 2; These endonucleases play a role in DNA repair. Cleave phosphodiester bonds at apurinic or apyrimidinic sites; the alignment also contains hexulose-6-phosphate isomerases, enzymes that catalyze the epimerization of...; Region: AP2Ec; cl12060 755731006741 Metal-binding active site; metal-binding site 755731006742 AP (apurinic/apyrimidinic) site pocket; other site 755731006743 M18 Peptidase Aminopeptidase I; Region: M18_API; cd05659 755731006744 Aminopeptidase I zinc metalloprotease (M18); Region: Peptidase_M18; pfam02127 755731006745 oligomer interface [polypeptide binding]; other site 755731006746 putative active site [active] 755731006747 metal binding site [ion binding]; metal-binding site 755731006748 histidinol-phosphatase; Provisional; Region: PRK05588 755731006749 Polymerase and Histidinol Phosphatase domain; Region: PHP; cl17102 755731006750 active site 755731006751 Predicted tRNA(5-methylaminomethyl-2-thiouridylate) methyltransferase, contains the PP-loop ATPase domain [Translation, ribosomal structure and biogenesis]; Region: TrmU; COG0482 755731006752 tRNA methyl transferase. This family represents tRNA(5-methylaminomethyl-2-thiouridine)-methyltransferase which is involved in the biosynthesis of the modified nucleoside 5-methylaminomethyl-2-thiouridine present in the wobble position of some tRNAs; Region: tRNA_Me_trans; cd01998 755731006753 Ligand Binding Site [chemical binding]; other site 755731006754 NifU homolog involved in Fe-S cluster formation [Energy production and conversion]; Region: IscU; COG0822 755731006755 Iron-sulfur cluster scaffold-like proteins; Region: IscU_like; cd06664 755731006756 trimerization site [polypeptide binding]; other site 755731006757 active site 755731006758 Cysteine sulfinate desulfinase/cysteine desulfurase and related enzymes [Amino acid transport and metabolism]; Region: NifS; COG1104 755731006759 cysteine desulfurase NifS; Region: FeS_nifS; TIGR03402 755731006760 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 755731006761 catalytic residue [active] 755731006762 Predicted transcriptional regulator [Transcription]; Region: COG1959 755731006763 Transcriptional regulator; Region: Rrf2; cl17282 755731006764 Uncharacterized protein family (UPF0180); Region: UPF0180; cl04214 755731006765 Predicted permease [General function prediction only]; Region: COG2056 755731006766 recombination factor protein RarA; Reviewed; Region: PRK13342 755731006767 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 755731006768 Walker A motif; other site 755731006769 ATP binding site [chemical binding]; other site 755731006770 Walker B motif; other site 755731006771 DNA polymerase III, delta subunit; Region: DNA_pol3_delta; pfam06144 755731006772 arginine finger; other site 755731006773 MgsA AAA+ ATPase C terminal; Region: MgsA_C; pfam12002 755731006774 Copper amine oxidase N-terminal domain; Region: Cu_amine_oxidN1; pfam07833 755731006775 Trypsin-like peptidase domain; Region: Trypsin_2; pfam13365 755731006776 PDZ domain of tryspin-like serine proteases, such as DegP/HtrA, which are oligomeric proteins involved in heat-shock response, chaperone function, and apoptosis. May be responsible for substrate recognition and/or binding, as most PDZ domains bind...; Region: PDZ_serine_protease; cd00987 755731006777 protein binding site [polypeptide binding]; other site 755731006778 2'-5' RNA ligase; Region: 2_5_ligase; TIGR02258 755731006779 LigT like Phosphoesterase; Region: LigT_PEase; pfam02834 755731006780 LigT like Phosphoesterase; Region: LigT_PEase; pfam02834 755731006781 Nucleoside-diphosphate-sugar pyrophosphorylase involved in lipopolysaccharide biosynthesis/translation initiation factor 2B, gamma/epsilon subunits (eIF-2Bgamma/eIF-2Bepsilon) [Cell envelope biogenesis, outer membrane / Translation, ribosomal structure...; Region: GCD1; COG1208 755731006782 NTP_transferases catalyze the transfer of nucleotides onto phosphosugars; Region: NTP_transferase; cd04181 755731006783 active site 755731006784 Substrate binding site; other site 755731006785 Mg++ binding site; other site 755731006786 Left-handed parallel beta-Helix (LbetaH or LbH) domain: The alignment contains 5 turns, each containing three imperfect tandem repeats of a hexapeptide repeat motif (X-[STAV]-X-[LIV]-[GAED]-X). Proteins containing hexapeptide repeats are often enzymes...; Region: LbetaH; cl00160 755731006787 putative trimer interface [polypeptide binding]; other site 755731006788 putative CoA binding site [chemical binding]; other site 755731006789 phosphoglucosamine mutase; Region: Arch_GlmM; TIGR03990 755731006790 GTP-mannose-1-phosphate guanyltransferase (MPG1 transferase), also known as GDP-mannose pyrophosphorylase, is a bifunctional enzyme with both phosphomannose isomerase (PMI) activity and GDP-mannose phosphorylase (GMP) activity. The protein contains an...; Region: MPG1_transferase; cd05805 755731006791 GTP-binding protein LepA; Provisional; Region: PRK05433 755731006792 LepA also known as Elongation Factor 4 (EF4); Region: LepA; cd01890 755731006793 G1 box; other site 755731006794 putative GEF interaction site [polypeptide binding]; other site 755731006795 GTP/Mg2+ binding site [chemical binding]; other site 755731006796 Switch I region; other site 755731006797 G2 box; other site 755731006798 G3 box; other site 755731006799 Switch II region; other site 755731006800 G4 box; other site 755731006801 G5 box; other site 755731006802 lepA_II: This subfamily represents the domain II of LepA, a GTP-binding protein localized in the cytoplasmic membrane. The N-terminal domain of LepA shares regions of homology to translation factors. In terms of interaction with the ribosome, EF-G, EF-Tu...; Region: lepA_II; cd03699 755731006803 lepA_C: This family represents the C-terminal region of LepA, a GTP-binding protein localized in the cytoplasmic membrane. LepA is ubiquitous in Bacteria and Eukaryota (e.g. Saccharomyces cerevisiae GUF1p), but is missing from Archaea. LepA exhibits...; Region: lepA_C; cd03709 755731006804 GTP-binding protein LepA C-terminus; Region: LepA_C; pfam06421 755731006805 Domain of unknown function (DUF4163); Region: DUF4163; pfam13739 755731006806 Protein of unknown function (DUF3298); Region: DUF3298; pfam11738 755731006807 Copper amine oxidase N-terminal domain; Region: Cu_amine_oxidN1; pfam07833 755731006808 DNA polymerase III PolC; Validated; Region: polC; PRK00448 755731006809 stage II sporulation protein P; Region: spore_II_P; TIGR02867 755731006810 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 755731006811 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 755731006812 active site 755731006813 phosphorylation site [posttranslational modification] 755731006814 intermolecular recognition site; other site 755731006815 dimerization interface [polypeptide binding]; other site 755731006816 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 755731006817 DNA binding site [nucleotide binding] 755731006818 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 755731006819 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 755731006820 dimer interface [polypeptide binding]; other site 755731006821 phosphorylation site [posttranslational modification] 755731006822 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 755731006823 ATP binding site [chemical binding]; other site 755731006824 Mg2+ binding site [ion binding]; other site 755731006825 G-X-G motif; other site 755731006826 BadF/BadG/BcrA/BcrD ATPase family; Region: BcrAD_BadFG; cl17271 755731006827 Activator of 2-hydroxyglutaryl-CoA dehydratase (HSP70-class ATPase domain) [Lipid metabolism]; Region: COG1924 755731006828 BadF/BadG/BcrA/BcrD ATPase family; Region: BcrAD_BadFG; cl17271 755731006829 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3580 755731006830 2-hydroxyglutaryl-CoA dehydratase, D-component; Region: HGD-D; pfam06050 755731006831 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3581 755731006832 aspartyl-tRNA synthetase; Validated; Region: aspS; PRK00476 755731006833 EcAspRS_like_N: N-terminal, anticodon recognition domain of the type found in Escherichia coli aspartyl-tRNA synthetase (AspRS), the human mitochondrial (mt) AspRS-2, the discriminating (D) Thermus thermophilus AspRS-1, and the nondiscriminating (ND)...; Region: EcAspRS_like_N; cd04317 755731006834 dimer interface [polypeptide binding]; other site 755731006835 anticodon binding site; other site 755731006836 Asp tRNA synthetase (aspRS) class II core domain. Class II assignment is based upon its structure and the presence of three characteristic sequence motifs. AspRS is a homodimer, which attaches a specific amino acid to the 3' OH group of ribose of...; Region: AspRS_core; cd00777 755731006837 homodimer interface [polypeptide binding]; other site 755731006838 motif 1; other site 755731006839 active site 755731006840 motif 2; other site 755731006841 GAD domain; Region: GAD; pfam02938 755731006842 Asp tRNA synthetase (aspRS) class II core domain. Class II assignment is based upon its structure and the presence of three characteristic sequence motifs. AspRS is a homodimer, which attaches a specific amino acid to the 3' OH group of ribose of...; Region: AspRS_core; cd00777 755731006843 motif 3; other site 755731006844 Histidyl-tRNA synthetase [Translation, ribosomal structure and biogenesis]; Region: HisS; COG0124 755731006845 Class II Histidinyl-tRNA synthetase (HisRS)-like catalytic core domain. HisRS is a homodimer. It is responsible for the attachment of histidine to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for...; Region: HisRS-like_core; cd00773 755731006846 dimer interface [polypeptide binding]; other site 755731006847 motif 1; other site 755731006848 active site 755731006849 motif 2; other site 755731006850 motif 3; other site 755731006851 HisRS Histidyl-anticodon binding domain. HisRS belongs to class II aminoacyl-tRNA synthetases (aaRS). This alignment contains the anticodon binding domain, which is responsible for specificity in tRNA-binding, so that the activated amino acid is...; Region: HisRS_anticodon; cd00859 755731006852 anticodon binding site; other site 755731006853 coproporphyrinogen III oxidase; Provisional; Region: PRK08207 755731006854 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 755731006855 FeS/SAM binding site; other site 755731006856 Zn-dependent hydrolases, including glyoxylases [General function prediction only]; Region: GloB; COG0491 755731006857 D-Tyrosyl-tRNAtyr deacylases; a class of tRNA-dependent hydrolases which are capable of hydrolyzing the ester bond of D-Tyrosyl-tRNA reducing the level of cellular D-Tyrosine while recycling the peptidyl-tRNA; found in bacteria and in eukaryotes but not...; Region: Dtyr_deacylase; cd00563 755731006858 putative active site [active] 755731006859 dimerization interface [polypeptide binding]; other site 755731006860 putative tRNAtyr binding site [nucleotide binding]; other site 755731006861 Guanosine polyphosphate pyrophosphohydrolases/synthetases [Signal transduction mechanisms / Transcription]; Region: SpoT; COG0317 755731006862 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 755731006863 Zn2+ binding site [ion binding]; other site 755731006864 Mg2+ binding site [ion binding]; other site 755731006865 Nucleotidyltransferase (NT) domain of RelA- and SpoT-like ppGpp synthetases and hydrolases; Region: NT_Rel-Spo_like; cd05399 755731006866 synthetase active site [active] 755731006867 NTP binding site [chemical binding]; other site 755731006868 metal binding site [ion binding]; metal-binding site 755731006869 TGS_RelA_SpoT: The RelA (SpoT) protein, also referred to as ppGpp hydrolase/synthetase, is a ribosome-associated protein that is activated during amino acid starvation and thought to mediate the stringent response. RelA contains a TGS domain, named after...; Region: TGS_RelA_SpoT; cd01668 755731006870 ACT domain found C-terminal of the RelA/SpoT domains; Region: ACT_RelA-SpoT; cd04876 755731006871 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 755731006872 active site 755731006873 Glycosyl hydrolase family 43; Region: GH43_AXH_1; cd09003 755731006874 substrate binding site [chemical binding]; other site 755731006875 active site 755731006876 Carbohydrate Binding Module 6 (CBM6); many are appended to glycoside hydrolase (GH) family 11 and GH43 xylanase domains; Region: CBM6_xylanase-like; cd04084 755731006877 metal binding site [ion binding]; metal-binding site 755731006878 ligand binding site [chemical binding]; other site 755731006879 single-stranded-DNA-specific exonuclease RecJ; Region: recJ; TIGR00644 755731006880 DHH family; Region: DHH; pfam01368 755731006881 DHHA1 domain; Region: DHHA1; pfam02272 755731006882 DNA polymerase III subunit delta; Reviewed; Region: holA; PRK05574 755731006883 DNA polymerase III, delta subunit; Region: DNA_pol3_delta; pfam06144 755731006884 Predicted membrane metal-binding protein [General function prediction only]; Region: ComEC; COG0658 755731006885 Domain of unknown function (DUF4131); Region: DUF4131; pfam13567 755731006886 Competence protein; Region: Competence; pfam03772 755731006887 Predicted hydrolase (metallo-beta-lactamase superfamily) [General function prediction only]; Region: ComEC; COG2333 755731006888 Metallo-beta-lactamase superfamily; Region: Lactamase_B; smart00849 755731006889 Bacterial SH3 domain; Region: SH3_3; pfam08239 755731006890 Bacterial SH3 domain; Region: SH3_3; cl17532 755731006891 Cell wall-associated hydrolases (invasion-associated proteins) [Cell envelope biogenesis, outer membrane]; Region: Spr; COG0791 755731006892 NlpC/P60 family; Region: NLPC_P60; pfam00877 755731006893 Acetyltransferases [General function prediction only]; Region: RimI; COG0456 755731006894 Acetyltransferase (GNAT) family; Region: Acetyltransf_1; pfam00583 755731006895 Transcriptional regulators [Transcription]; Region: MarR; COG1846 755731006896 MarR family; Region: MarR_2; pfam12802 755731006897 Predicted membrane protein [Function unknown]; Region: COG1511 755731006898 YhgE/Pip N-terminal domain; Region: pip_yhgE_Nterm; TIGR03061 755731006899 X-X-X-Leu-X-X-Gly heptad repeats; Region: xxxLxxG_by_4; TIGR03057 755731006900 YhgE/Pip C-terminal domain; Region: pip_yhgE_Cterm; TIGR03062 755731006901 O-acetylhomoserine sulfhydrylase [Amino acid transport and metabolism]; Region: MET17; COG2873 755731006902 CGS_like: Cystathionine gamma-synthase is a PLP dependent enzyme and catalyzes the committed step of methionine biosynthesis. This pathway is unique to microorganisms and plants, rendering the enzyme an attractive target for the development of...; Region: CGS_like; cd00614 755731006903 homodimer interface [polypeptide binding]; other site 755731006904 substrate-cofactor binding pocket; other site 755731006905 pyridoxal 5'-phosphate binding site [chemical binding]; other site 755731006906 catalytic residue [active] 755731006907 Transcriptional regulators [Transcription]; Region: Lrp; COG1522 755731006908 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 755731006909 putative DNA binding site [nucleotide binding]; other site 755731006910 putative Zn2+ binding site [ion binding]; other site 755731006911 AsnC family; Region: AsnC_trans_reg; pfam01037 755731006912 Fibronectin-binding protein A N-terminus (FbpA); Region: FbpA; pfam05833 755731006913 Domain of unknown function (DUF814); Region: DUF814; pfam05670 755731006914 aspartate aminotransferase; Provisional; Region: PRK06836 755731006915 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 755731006916 pyridoxal 5'-phosphate binding site [chemical binding]; other site 755731006917 homodimer interface [polypeptide binding]; other site 755731006918 catalytic residue [active] 755731006919 Escherichia coli PhnB and similar proteins; the E. coli phnB gene is found next to an operon involved in the cleavage of carbon-phosphorus bonds in unactivated alkylphosphonates; Region: PhnB_like; cd06588 755731006920 dimer interface [polypeptide binding]; other site 755731006921 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 755731006922 Uncharacterized conserved protein [Function unknown]; Region: COG2006 755731006923 Domain of unknown function (DUF362); Region: DUF362; pfam04015 755731006924 Protein of unknown function (DUF3953); Region: DUF3953; pfam13129 755731006925 germination protein, Ger(x)C family; Region: spore_ger_x_C; TIGR02887 755731006926 Spore germination B3/ GerAC like, C-terminal; Region: Spore_GerAC; pfam05504 755731006927 Spore germination protein; Region: Spore_permease; cl17796 755731006928 Bacillus/Clostridium GerA spore germination protein; Region: GerA; pfam03323 755731006929 Glycosyl hydrolase family 43; Region: GH43_6; cd08985 755731006930 active site 755731006931 Dockerin type I repeat; Region: Dockerin_1; pfam00404 755731006932 Dockerin type I repeat; Region: Dockerin_1; pfam00404 755731006933 SGNH_hydrolase subfamily, similar to the putative arylesterase/acylhydrolase from the rumen anaerobe Prevotella bryantii XynE. The P. bryantii XynE gene is located in a xylanase gene cluster. SGNH hydrolases are a diverse family of lipases and esterases; Region: XynE_like; cd01830 755731006934 active site 755731006935 catalytic triad [active] 755731006936 oxyanion hole [active] 755731006937 Dockerin type I repeat; Region: Dockerin_1; pfam00404 755731006938 Domain of unknown function (DUF303); Region: DUF303; pfam03629 755731006939 Protein of unknown function (DUF2798); Region: DUF2798; pfam11391 755731006940 Protein of unknown function, DUF624; Region: DUF624; pfam04854 755731006941 ATP-dependent RNA helicase DbpA; Provisional; Region: PRK11776 755731006942 DEAD-box helicases. A diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker B motif; Region: DEADc; cd00268 755731006943 ATP binding site [chemical binding]; other site 755731006944 Mg++ binding site [ion binding]; other site 755731006945 motif III; other site 755731006946 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 755731006947 nucleotide binding region [chemical binding]; other site 755731006948 ATP-binding site [chemical binding]; other site 755731006949 RNA recognition motif (RRM) superfamily; Region: RRM_SF; cl17169 755731006950 Acetyltransferase (GNAT) domain; Region: Acetyltransf_3; pfam13302 755731006951 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl17182 755731006952 Patatins and Phospholipases; Region: Patatin_and_cPLA2; cl11396 755731006953 active site 755731006954 nucleophile elbow; other site 755731006955 Patatins and Phospholipases; Region: Patatin_and_cPLA2; cl11396 755731006956 NAD-dependent DNA ligase LigA; Validated; Region: ligA; PRK07956 755731006957 NAD+ dependent DNA ligase adenylation domain. DNA ligases catalyze the crucial step of joining the breaks in duplex DNA during DNA replication, repair and recombination, utilizing either ATP or NAD(+) as a cofactor, but using the same basic reaction...; Region: LIGANc; cl03295 755731006958 nucleotide binding pocket [chemical binding]; other site 755731006959 K-X-D-G motif; other site 755731006960 catalytic site [active] 755731006961 NAD-dependent DNA ligase OB-fold domain; Region: DNA_ligase_OB; pfam03120 755731006962 Breast Cancer Suppressor Protein (BRCA1), carboxy-terminal domain. The BRCT domain is found within many DNA damage repair and cell cycle checkpoint proteins. The unique diversity of this domain superfamily allows BRCT modules to interact forming homo...; Region: BRCT; cd00027 755731006963 Dimer interface [polypeptide binding]; other site 755731006964 BRCT sequence motif; other site 755731006965 Peptidase M50B-like; Region: Peptidase_M50B; pfam13398 755731006966 germination protease; Provisional; Region: PRK12362 755731006967 30S ribosomal protein S20; Reviewed; Region: rpsT; PRK00239 755731006968 coproporphyrinogen III oxidase; Provisional; Region: PRK05799 755731006969 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 755731006970 FeS/SAM binding site; other site 755731006971 HemN C-terminal domain; Region: HemN_C; pfam06969 755731006972 Na+-driven multidrug efflux pump [Defense mechanisms]; Region: NorM; COG0534 755731006973 Uncharacterized subfamily of the multidrug and toxic compound extrusion (MATE) proteins; Region: MATE_like_8; cd13134 755731006974 Response regulator containing CheY-like receiver domain and AraC-type DNA-binding domain [Signal transduction mechanisms]; Region: COG4753 755731006975 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 755731006976 active site 755731006977 phosphorylation site [posttranslational modification] 755731006978 intermolecular recognition site; other site 755731006979 dimerization interface [polypeptide binding]; other site 755731006980 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 755731006981 Cache domain; Region: Cache_1; pfam02743 755731006982 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 755731006983 dimerization interface [polypeptide binding]; other site 755731006984 Histidine kinase; Region: His_kinase; pfam06580 755731006985 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 755731006986 ATP binding site [chemical binding]; other site 755731006987 Mg2+ binding site [ion binding]; other site 755731006988 G-X-G motif; other site 755731006989 Periplasmic sugar-binding domain of active transport systems that are members of the type I periplasmic binding protein (PBP1) superfamily; Region: PBP1_ABC_sugar_binding_like; cd01536 755731006990 Periplasmic binding protein domain; Region: Peripla_BP_4; pfam13407 755731006991 ligand binding site [chemical binding]; other site 755731006992 Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653 755731006993 Transmembrane subunit (TM) of Escherichia coli AraH and related proteins. E. coli AraH is the TM of a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of the monosaccharide arabinose. This group...; Region: TM_PBP1_transp_AraH_like; cd06579 755731006994 TM-ABC transporter signature motif; other site 755731006995 ABC-type sugar transport system, ATPase component [Carbohydrate transport and metabolism]; Region: MglA; COG1129 755731006996 First domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_I; cd03216 755731006997 Walker A/P-loop; other site 755731006998 ATP binding site [chemical binding]; other site 755731006999 Q-loop/lid; other site 755731007000 ABC transporter signature motif; other site 755731007001 Walker B; other site 755731007002 D-loop; other site 755731007003 H-loop/switch region; other site 755731007004 Second domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_II; cd03215 755731007005 ABC-type xylose transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: XylF; COG4213 755731007006 Periplasmic xylose-binding component of the ABC-type transport systems that belong to a family of pentose/hexose sugar-binding proteins of the type I periplasmic binding protein (PBP1) superfamily; Region: PBP1_ABC_xylose_binding; cd01538 755731007007 putative ligand binding site [chemical binding]; other site 755731007008 Glycosyltransferases, probably involved in cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: COG1215 755731007009 CESA_like is the cellulose synthase superfamily; Region: CESA_like; cd06423 755731007010 DXD motif; other site 755731007011 Thiamine monophosphate synthase (TMP synthase)/TenI. TMP synthase catalyzes an important step in the thiamine biosynthesis pathway, the substitution of the pyrophosphate of 2-methyl-4-amino-5- hydroxymethylpyrimidine pyrophosphate by 4-methyl-5-; Region: TMP_TenI; cd00564 755731007012 thiamine phosphate binding site [chemical binding]; other site 755731007013 active site 755731007014 pyrophosphate binding site [ion binding]; other site 755731007015 4-methyl-5-beta-hydroxyethylthiazole (Thz) kinase catalyzes the phosphorylation of the hydroxylgroup of Thz. A reaction that allows cells to recycle Thz into the thiamine biosynthesis pathway, as an alternative to its synthesis from cysteine, tyrosine...; Region: THZ_kinase; cd01170 755731007016 substrate binding site [chemical binding]; other site 755731007017 multimerization interface [polypeptide binding]; other site 755731007018 ATP binding site [chemical binding]; other site 755731007019 thiamine biosynthesis protein ThiC; Provisional; Region: PRK13352 755731007020 thiamine biosynthesis protein ThiC; Region: thiC; TIGR00190 755731007021 4-amino-5-hydroxymethyl-2-methyl-pyrimidine phosphate kinase (HMPP-kinase) catalyzes two consecutive phosphorylation steps in the thiamine phosphate biosynthesis pathway, leading to the synthesis of vitamin B1. The first step is the phosphorylation of...; Region: HMPP_kinase; cd01169 755731007022 dimer interface [polypeptide binding]; other site 755731007023 substrate binding site [chemical binding]; other site 755731007024 ATP binding site [chemical binding]; other site 755731007025 Tocopherol cyclase; Region: Tocopherol_cycl; cl14571 755731007026 ferric uptake regulator; Provisional; Region: fur; PRK09462 755731007027 Ferric uptake regulator(Fur) and related metalloregulatory proteins; typically iron-dependent, DNA-binding repressors and activators; Region: Fur_like; cd07153 755731007028 metal binding site 2 [ion binding]; metal-binding site 755731007029 putative DNA binding helix; other site 755731007030 metal binding site 1 [ion binding]; metal-binding site 755731007031 dimer interface [polypeptide binding]; other site 755731007032 structural Zn2+ binding site [ion binding]; other site 755731007033 SIR2 superfamily of proteins includes silent information regulator 2 (Sir2) enzymes which catalyze NAD+-dependent protein/histone deacetylation, where the acetyl group from the lysine epsilon-amino group is transferred to the ADP-ribose moiety of NAD+; Region: SIR2; cl00195 755731007034 Fe2+ transport system protein B [Inorganic ion transport and metabolism]; Region: FeoB; COG0370 755731007035 Ferrous iron transport protein B (FeoB) family; Region: FeoB; cd01879 755731007036 G1 box; other site 755731007037 GTP/Mg2+ binding site [chemical binding]; other site 755731007038 Switch I region; other site 755731007039 G2 box; other site 755731007040 G3 box; other site 755731007041 Switch II region; other site 755731007042 G4 box; other site 755731007043 G5 box; other site 755731007044 Nucleoside recognition; Region: Gate; pfam07670 755731007045 Ferrous iron transport protein B C terminus; Region: FeoB_C; pfam07664 755731007046 Nucleoside recognition; Region: Gate; pfam07670 755731007047 This entry represents the core domain of the ferrous iron (Fe2+) transport protein FeoA found in bacteria; Region: FeoA; smart00899 755731007048 Protein of unknown function (DUF1667); Region: DUF1667; cl17602 755731007049 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox_2; pfam07992 755731007050 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500 755731007051 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 755731007052 Predicted dehydrogenase [General function prediction only]; Region: COG0579 755731007053 hydroxyglutarate oxidase; Provisional; Region: PRK11728 755731007054 BFD-like [2Fe-2S] binding domain; Region: Fer2_BFD; pfam04324 755731007055 Concanavalin A-like lectin/glucanases superfamily; Region: Laminin_G_3; pfam13385 755731007056 Concanavalin A-like lectin/glucanases superfamily; Region: Laminin_G_3; pfam13385 755731007057 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 755731007058 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 755731007059 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 755731007060 Mg2+ and Co2+ transporters [Inorganic ion transport and metabolism]; Region: CorA; COG0598 755731007061 uncharacterized bacterial subfamily of the Escherichia coli CorA-Salmonella typhimurium ZntB family; Region: EcCorA_ZntB-like_u2; cd12827 755731007062 Cl binding site [ion binding]; other site 755731007063 oligomer interface [polypeptide binding]; other site 755731007064 ykoK leader; IMG reference gene:2509529145 755731007065 lumazine synthase (6,7-dimethyl-8-ribityllumazine synthase, LS), catalyzes the penultimate step in the biosynthesis of riboflavin (vitamin B2); type-I; Region: Lumazine_synthase-I; cd09209 755731007066 homopentamer interface [polypeptide binding]; other site 755731007067 active site 755731007068 bifunctional 3,4-dihydroxy-2-butanone 4-phosphate synthase/GTP cyclohydrolase II protein; Provisional; Region: PRK09311 755731007069 3,4-dihydroxy-2-butanone 4-phosphate synthase; Region: DHBP_synthase; pfam00926 755731007070 GTP cyclohydrolase II (RibA). GTP cyclohydrolase II catalyzes the conversion of GTP to 2,5-diamino-6-ribosylamino-4(3H)-pyrimidinone 5' phosphate, formate, pyrophosphate (APy), and GMP in the biosynthetic pathway of riboflavin. Riboflavin is the...; Region: GTP_cyclohydro2; cd00641 755731007071 dimerization interface [polypeptide binding]; other site 755731007072 active site 755731007073 riboflavin synthase subunit alpha; Provisional; Region: PRK09289 755731007074 Lumazine binding domain; Region: Lum_binding; pfam00677 755731007075 Lumazine binding domain; Region: Lum_binding; pfam00677 755731007076 riboflavin biosynthesis protein RibD; Region: eubact_ribD; TIGR00326 755731007077 Riboflavin-specific deaminase. Riboflavin biosynthesis protein RibD (Diaminohydroxyphosphoribosylaminopyrimidine deaminase) catalyzes the deamination of 2,5-diamino-6-ribosylamino-4(3H)-pyrimidinone 5'-phosphate, which is an intermediate step in the...; Region: Riboflavin_deaminase-reductase; cd01284 755731007078 catalytic motif [active] 755731007079 Zn binding site [ion binding]; other site 755731007080 RibD C-terminal domain; Region: RibD_C; cl17279 755731007081 cyanobacterial long protein repeat; Region: swm_rep_I; TIGR02059 755731007082 Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all...; Region: FN3; cd00063 755731007083 Interdomain contacts; other site 755731007084 Cytokine receptor motif; other site 755731007085 S-layer homology domain; Region: SLH; pfam00395 755731007086 S-layer homology domain; Region: SLH; pfam00395 755731007087 DNA polymerase IV; Reviewed; Region: PRK03103 755731007088 DNA Polymerase IV/Kappa; Region: PolY_Pol_IV_kappa; cd03586 755731007089 active site 755731007090 DNA binding site [nucleotide binding] 755731007091 Uncharacterized ACR, COG2135; Region: DUF159; pfam02586 755731007092 C-terminal processing peptidase family S41; Region: Peptidase_S41; cl02526 755731007093 C-terminal processing peptidase family S41; Region: Peptidase_S41; cl02526 755731007094 Active site serine [active] 755731007095 This domain superfamily is found in a variety of structurally related metalloproteins, including the type I extradiol dioxygenases, glyoxalase I and a group of antibiotic resistance proteins; Region: Glo_EDI_BRP_like; cl14632 755731007096 active site 755731007097 Helix-turn-helix domain; Region: HTH_18; pfam12833 755731007098 SGNH_hydrolase, or GDSL_hydrolase, is a diverse family of lipases and esterases. The tertiary fold of the enzyme is substantially different from that of the alpha/beta hydrolase family and unique among all known hydrolases; its active site closely...; Region: SGNH_hydrolase; cd00229 755731007099 active site 755731007100 catalytic triad [active] 755731007101 oxyanion hole [active] 755731007102 Dockerin type I repeat; Region: Dockerin_1; pfam00404 755731007103 Zn-ribbon-containing, possibly nucleic-acid-binding protein (DUF2310); Region: DUF2310; cl02380 755731007104 YceG-like family; Region: YceG; pfam02618 755731007105 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 755731007106 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cl17315 755731007107 Protein of unknown function (DUF342); Region: DUF342; pfam03961 755731007108 RNA polymerase sigma factor, FliA/WhiG family; Region: FliA_WhiG; TIGR02479 755731007109 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 755731007110 Sigma-70 region 3; Region: Sigma70_r3; pfam04539 755731007111 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 755731007112 DNA binding residues [nucleotide binding] 755731007113 chemoreceptor glutamine deamidase CheD; Provisional; Region: PRK13488 755731007114 Chemotaxis protein CheC, inhibitor of MCP methylation [Cell motility and secretion / Signal transduction mechanisms]; Region: CheC; COG1776 755731007115 CheC-like family; Region: CheC; pfam04509 755731007116 CheC-like family; Region: CheC; pfam04509 755731007117 CheW, a small regulator protein, unique to the chemotaxis signalling in prokaryotes and archea. CheW interacts with the histidine kinase CheA, most likely with the related regulatory domain of CheA. CheW is proposed to form signalling arrays together...; Region: CheW; cd00732 755731007118 putative CheA interaction surface; other site 755731007119 Chemotaxis protein histidine kinase and related kinases [Cell motility and secretion / Signal transduction mechanisms]; Region: CheA; COG0643 755731007120 Histidine Phosphotransfer domain, involved in signalling through a two part component systems in which an autophosphorylating histidine protein kinase serves as a phosphoryl donor to a response regulator protein; the response regulator protein is...; Region: HPT; cd00088 755731007121 putative binding surface; other site 755731007122 active site 755731007123 P2 response regulator binding domain; Region: P2; pfam07194 755731007124 Signal transducing histidine kinase, homodimeric domain; Region: H-kinase_dim; pfam02895 755731007125 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 755731007126 ATP binding site [chemical binding]; other site 755731007127 Mg2+ binding site [ion binding]; other site 755731007128 G-X-G motif; other site 755731007129 CheA regulatory domain; CheA is a histidine protein kinase present in bacteria and archea. Activated by the chemotaxis receptor a histidine phosphoryl group from CheA is passed directly to an aspartate in the response regulator CheY. This signalling...; Region: CheA_reg; cd00731 755731007130 chemotaxis-specific methylesterase; Provisional; Region: PRK00742 755731007131 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 755731007132 active site 755731007133 phosphorylation site [posttranslational modification] 755731007134 intermolecular recognition site; other site 755731007135 dimerization interface [polypeptide binding]; other site 755731007136 CheB methylesterase; Region: CheB_methylest; pfam01339 755731007137 Antiactivator of flagellar biosynthesis FleN, an ATPase [Cell motility]; Region: flhG; COG0455 755731007138 FleN is a member of the Fer4_NifH superfamily. It shares the common function as an ATPase, with the ATP-binding domain at the N-terminus. In Pseudomonas aeruginosa, FleN gene is involved in regulating the number of flagella and chemotactic motility by...; Region: FleN-like; cd02038 755731007139 flagellar biosynthesis regulator FlhF; Validated; Region: flhF; PRK05703 755731007140 The Fer4_NifH superfamily contains a variety of proteins which share a common ATP-binding domain. Functionally, proteins in this superfamily use the energy from hydrolysis of NTP to transfer electron or ion; Region: Fer4_NifH; cl17203 755731007141 FHIPEP family; Region: FHIPEP; pfam00771 755731007142 flagellar biosynthesis protein FlhA; Validated; Region: flhA; PRK06012 755731007143 flagellar biosynthesis protein FlhB; Reviewed; Region: flhB; PRK05702 755731007144 Uncharacterized homolog of the cytoplasmic domain of flagellar protein FhlB [Function unknown]; Region: COG2257 755731007145 flagellar biosynthesis protein FliR; Reviewed; Region: fliR; PRK05701 755731007146 flagellar biosynthesis protein FliQ; Validated; Region: fliQ; PRK05700 755731007147 flagellar biosynthesis protein FliP; Reviewed; Region: fliP; PRK05699 755731007148 flagellar biosynthetic protein FliO; Region: FliO_TIGR; TIGR03500 755731007149 FOG: CheY-like receiver [Signal transduction mechanisms]; Region: CheY; COG0784 755731007150 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 755731007151 active site 755731007152 phosphorylation site [posttranslational modification] 755731007153 intermolecular recognition site; other site 755731007154 dimerization interface [polypeptide binding]; other site 755731007155 flagellar motor switch protein; Validated; Region: PRK08119 755731007156 CheC-like family; Region: CheC; pfam04509 755731007157 flagellar motor switch protein FliN; Region: fliN; TIGR02480 755731007158 flagellar motor switch protein FliM; Validated; Region: fliM; PRK06666 755731007159 Surface presentation of antigens (SPOA); Region: SpoA; pfam01052 755731007160 Flagellar basal body-associated protein FliL; Region: FliL; cl00681 755731007161 Flagellar protein (FlbD); Region: FlbD; pfam06289 755731007162 flagellar hook protein FlgE; Validated; Region: flgE; PRK05682 755731007163 Flagella basal body rod protein; Region: Flg_bb_rod; pfam00460 755731007164 Flagellar basal body protein FlaE; Region: FlaE; pfam07559 755731007165 Flagellar basal body rod FlgEFG protein C-terminal; Region: Flg_bbr_C; pfam06429 755731007166 Protein of unknown function (DUF3766); Region: DUF3766; cl11797 755731007167 Flagellar hook capping protein - N-terminal region; Region: FlgD; pfam03963 755731007168 Flagellar hook-length control protein [Cell motility and secretion]; Region: FliK; COG3144 755731007169 Flagellar hook-length control protein FliK; Region: Flg_hook; pfam02120 755731007170 Uncharacterized conserved protein [Function unknown]; Region: COG3334 755731007171 flagellar biosynthesis chaperone; Validated; Region: fliJ; PRK07720 755731007172 flagellar export protein FliJ; Region: flagell_FliJ; TIGR02473 755731007173 flagellar protein export ATPase FliI; Region: FliI_clade2; TIGR03497 755731007174 ATP synthase alpha/beta family, beta-barrel domain; Region: ATP-synt_ab_N; pfam02874 755731007175 Flagellum-specific ATPase/type III secretory pathway virulence-related protein. This group of ATPases are responsible for the export of flagellum and virulence-related proteins. The bacterial flagellar motor is similar to the F0F1-ATPase, in that they...; Region: ATPase_flagellum-secretory_path_III; cd01136 755731007176 Walker A motif/ATP binding site; other site 755731007177 Walker B motif; other site 755731007178 type III secretion apparatus protein, HrpE/YscL family; Region: HrpE_YscL_not; TIGR02499 755731007179 Flagellar assembly protein FliH; Region: FliH; pfam02108 755731007180 flagellar motor switch protein G; Validated; Region: fliG; PRK05686 755731007181 FliG C-terminal domain; Region: FliG_C; pfam01706 755731007182 flagellar MS-ring protein; Reviewed; Region: fliF; PRK06007 755731007183 Secretory protein of YscJ/FliF family; Region: YscJ_FliF; cl01907 755731007184 Flagellar M-ring protein C-terminal; Region: YscJ_FliF_C; pfam08345 755731007185 Flagellar hook-basal body complex protein FliE; Region: FliE; pfam02049 755731007186 flagellar basal body rod protein FlgC; Reviewed; Region: flgC; PRK05681 755731007187 Flagella basal body rod protein; Region: Flg_bb_rod; pfam00460 755731007188 Flagellar basal body rod FlgEFG protein C-terminal; Region: Flg_bbr_C; pfam06429 755731007189 flagellar basal body rod protein FlgB; Reviewed; Region: flgB; PRK05680 755731007190 flagellar basal body rod protein FlgB; Reviewed; Region: flgB; PRK07182 755731007191 tRNA (uracil-5-)-methyltransferase Gid; Reviewed; Region: PRK05335 755731007192 Glucose inhibited division protein A; Region: GIDA; pfam01134 755731007193 DNA topoisomerase I; Validated; Region: PRK05582 755731007194 TOPRIM_TopoIA_TopoI: The topoisomerase-primase (TORPIM) domain found in members of the type IA family of DNA topoisomerases (Topo IA) similar to Escherichia coli DNA topoisomerase I. Type IA DNA topoisomerases remove (relax) negative supercoils in the...; Region: TOPRIM_TopoIA_TopoI; cd03363 755731007195 active site 755731007196 interdomain interaction site; other site 755731007197 putative metal-binding site [ion binding]; other site 755731007198 nucleotide binding site [chemical binding]; other site 755731007199 DNA Topoisomerase, subtype IA; DNA-binding, ATP-binding and catalytic domain of bacterial DNA topoisomerases I and III, and eukaryotic DNA topoisomerase III and eubacterial and archael reverse gyrases. Topoisomerases clevage single or double stranded DNA...; Region: TOP1Ac; cd00186 755731007200 domain I; other site 755731007201 DNA binding groove [nucleotide binding] 755731007202 phosphate binding site [ion binding]; other site 755731007203 domain II; other site 755731007204 domain III; other site 755731007205 nucleotide binding site [chemical binding]; other site 755731007206 catalytic site [active] 755731007207 domain IV; other site 755731007208 Topoisomerase DNA binding C4 zinc finger; Region: zf-C4_Topoisom; pfam01396 755731007209 Site-specific recombinases, DNA invertase Pin homologs [DNA replication, recombination, and repair]; Region: PinR; COG1961 755731007210 Serine Recombinase family, catalytic domain; a DNA binding domain may be present either N- or C-terminal to the catalytic domain. These enzymes perform site-specific recombination of DNA molecules by a concerted, four-strand cleavage and rejoining...; Region: Ser_Recombinase; cd00338 755731007211 catalytic residues [active] 755731007212 catalytic nucleophile [active] 755731007213 Recombinase; Region: Recombinase; pfam07508 755731007214 Recombinase zinc beta ribbon domain; Region: Zn_ribbon_recom; pfam13408 755731007215 Bacteriophage holin; Region: Phage_holin_1; cl02344 755731007216 Helix-hairpin-helix motif; Region: HHH_3; pfam12836 755731007217 kelch-like protein; Provisional; Region: PHA03098 755731007218 Domain of unknown function (DUF4414); Region: DUF4414; pfam14377 755731007219 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG5410 755731007220 Terminase-like family; Region: Terminase_6; pfam03237 755731007221 Phage-related terminase [General function prediction only]; Region: COG5362; cl02216 755731007222 DNA breaking-rejoining enzymes, intergrase/recombinases, C-terminal catalytic domain. The tyrosine recombinase/integrase family share the same catalytic domain containing six conserved active site residues. The best-studied members of this diverse family...; Region: INT_REC_C; cd01182 755731007223 Integrase [DNA replication, recombination, and repair]; Region: XerC; COG0582 755731007224 active site 755731007225 catalytic residues [active] 755731007226 DNA binding site [nucleotide binding] 755731007227 Int/Topo IB signature motif; other site 755731007228 BRO family, N-terminal domain; Region: Bro-N; smart01040 755731007229 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 755731007230 DEAD-like helicases superfamily; Region: DEXDc; smart00487 755731007231 ATP binding site [chemical binding]; other site 755731007232 putative Mg++ binding site [ion binding]; other site 755731007233 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 755731007234 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 755731007235 non-specific DNA binding site [nucleotide binding]; other site 755731007236 salt bridge; other site 755731007237 sequence-specific DNA binding site [nucleotide binding]; other site 755731007238 Cro/C1-type HTH DNA-binding domain; Region: HTH_26; pfam13443 755731007239 DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213 755731007240 DNA protecting protein DprA; Region: dprA; TIGR00732 755731007241 DNA recombination-mediator protein A; Region: DNA_processg_A; pfam02481 755731007242 Predicted ATPase with chaperone activity [Posttranslational modification, protein turnover, chaperones]; Region: COG0606 755731007243 Subunit ChlI of Mg-chelatase; Region: ChlI; pfam13541 755731007244 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 755731007245 Walker A motif; other site 755731007246 ATP binding site [chemical binding]; other site 755731007247 Walker B motif; other site 755731007248 arginine finger; other site 755731007249 Magnesium chelatase, subunit ChlI; Region: Mg_chelatase_2; pfam13335 755731007250 transcriptional regulator NrdR; Validated; Region: nrdR; PRK00464 755731007251 ATP cone domain; Region: ATP-cone; pfam03477 755731007252 sporulation protein, YlmC/YmxH family; Region: spore_YlmC_YmxH; TIGR02888 755731007253 sporulation sigma factor SigG; Reviewed; Region: PRK08215 755731007254 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 755731007255 Sigma-70 region 3; Region: Sigma70_r3; pfam04539 755731007256 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 755731007257 DNA binding residues [nucleotide binding] 755731007258 sporulation sigma factor SigE; Reviewed; Region: PRK08301 755731007259 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 755731007260 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 755731007261 DNA binding residues [nucleotide binding] 755731007262 Sporulation factor SpoIIGA; Region: Peptidase_U4; pfam03419 755731007263 sigma-E processing peptidase SpoIIGA; Region: spore_II_GA; TIGR02854 755731007264 cell division protein FtsZ; Validated; Region: PRK09330 755731007265 FtsZ is a GTPase that is similar to the eukaryotic tubulins and is essential for cell division in prokaryotes. FtsZ is capable of polymerizing in a GTP-driven process into structures similar to those formed by tubulin. FtsZ forms a ring-shaped septum at...; Region: FtsZ_type1; cd02201 755731007266 nucleotide binding site [chemical binding]; other site 755731007267 SulA interaction site; other site 755731007268 Cell division ATPase FtsA [Cell division and chromosome partitioning]; Region: ftsA; COG0849 755731007269 Cell division protein FtsA; Region: FtsA; smart00842 755731007270 Cell division protein FtsA; Region: FtsA; pfam14450 755731007271 Protein of unknown function (DUF1290); Region: DUF1290; pfam06947 755731007272 POTRA domain, FtsQ-type; Region: POTRA_1; pfam08478 755731007273 UDP-N-acetylmuramyl tripeptide synthase [Cell envelope biogenesis, outer membrane]; Region: MurE; COG0769 755731007274 Mur ligase middle domain; Region: Mur_ligase_M; pfam08245 755731007275 Domain of unknown function (DUF1727); Region: DUF1727; pfam08353 755731007276 Type 1 glutamine amidotransferase (GATase1) domain found in Cobyric Acid Synthase (CobQ); Region: GATase1_CobQ; cd01750 755731007277 catalytic triad [active] 755731007278 3-deoxy-7-phosphoheptulonate synthase; Reviewed; Region: PRK08673 755731007279 phospho-2-dehydro-3-deoxyheptonate aldolase; Region: DAHP_synth_Bsub; TIGR01361 755731007280 Soluble lytic murein transglycosylase and related regulatory proteins (some contain LysM/invasin domains) [Cell envelope biogenesis, outer membrane]; Region: MltE; COG0741 755731007281 Lytic Transglycosylase (LT) and Goose Egg White Lysozyme (GEWL) domain. Members include the soluble and insoluble membrane-bound LTs in bacteria, the LTs in bacteriophage lambda, as well as, the eukaryotic "goose-type" lysozymes (GEWL). LTs...; Region: LT_GEWL; cd00254 755731007282 N-acetyl-D-glucosamine binding site [chemical binding]; other site 755731007283 catalytic residue [active] 755731007284 Dephospho-CoA kinase [Coenzyme metabolism]; Region: CoaE; COG0237 755731007285 Dephospho-coenzyme A kinase (DPCK, EC 2.7.1.24) catalyzes the phosphorylation of dephosphocoenzyme A (dCoA) to yield CoA, which is the final step in CoA biosynthesis; Region: DPCK; cd02022 755731007286 CoA-binding site [chemical binding]; other site 755731007287 ATP-binding [chemical binding]; other site 755731007288 DNA polymerase I; Provisional; Region: PRK05755 755731007289 PIN domain of the 5'-3' exonuclease of Taq DNA polymerase I and homologs; Region: PIN_53EXO; cd09859 755731007290 active site 755731007291 metal binding site 1 [ion binding]; metal-binding site 755731007292 putative 5' ssDNA interaction site; other site 755731007293 metal binding site 3; metal-binding site 755731007294 metal binding site 2 [ion binding]; metal-binding site 755731007295 H3TH domain of the 5'-3' exonuclease of Taq DNA polymerase I and homologs; Region: H3TH_53EXO; cd09898 755731007296 putative DNA binding site [nucleotide binding]; other site 755731007297 putative metal binding site [ion binding]; other site 755731007298 inactive DEDDy 3'-5' exonuclease domain of Bacillus stearothermophilus DNA polymerase I and similar family-A DNA polymerases; Region: DNA_polA_I_Bacillus_like_exo; cd06140 755731007299 Polymerase I functions primarily to fill DNA gaps that arise during DNA repair, recombination and replication; Region: DNA_pol_A_pol_I_C; cd08637 755731007300 active site 755731007301 DNA binding site [nucleotide binding] 755731007302 catalytic site [active] 755731007303 Putative zinc-finger; Region: zf-HC2; pfam13490 755731007304 RNA polymerase sigma factor RpoE; Provisional; Region: PRK09652 755731007305 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 755731007306 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 755731007307 DNA binding residues [nucleotide binding] 755731007308 Response regulator receiver domain; Region: Response_reg; pfam00072 755731007309 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 755731007310 active site 755731007311 phosphorylation site [posttranslational modification] 755731007312 intermolecular recognition site; other site 755731007313 dimerization interface [polypeptide binding]; other site 755731007314 This domain family includes the Enolpyruvate transferase (EPT) family and the RNA 3' phosphate cyclase family (RTPC). These 2 families differ in that EPT is formed by 3 repeats of an alpha-beta structural domain while RTPC has 3 similar repeats...; Region: EPT_RTPC-like; cl00288 755731007315 Coat F domain; Region: Coat_F; pfam07875 755731007316 Trk-type K+ transport systems, membrane components [Inorganic ion transport and metabolism]; Region: TrkG; COG0168 755731007317 potassium uptake protein, TrkH family; Region: 2a38; TIGR00933 755731007318 tyrosyl-tRNA synthetase; Validated; Region: PRK05912 755731007319 catalytic core domain of tyrosinyl-tRNA synthetase; Region: TyrRS_core; cd00805 755731007320 active site 755731007321 HIGH motif; other site 755731007322 dimer interface [polypeptide binding]; other site 755731007323 KMSKS motif; other site 755731007324 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 755731007325 RNA binding surface [nucleotide binding]; other site 755731007326 K+ transport systems, NAD-binding component [Inorganic ion transport and metabolism]; Region: TrkA; COG0569 755731007327 TrkA-N domain; Region: TrkA_N; pfam02254 755731007328 TrkA-C domain; Region: TrkA_C; pfam02080 755731007329 K+ transport systems, NAD-binding component [Inorganic ion transport and metabolism]; Region: TrkA; COG0569 755731007330 TrkA-N domain; Region: TrkA_N; pfam02254 755731007331 Predicted membrane protein [Function unknown]; Region: COG2323 755731007332 Domain of unknown function (DUF4363); Region: DUF4363; pfam14276 755731007333 Sodium/calcium exchanger protein; Region: Na_Ca_ex; pfam01699 755731007334 Ca2+/Na+ antiporter [Inorganic ion transport and metabolism]; Region: ECM27; COG0530 755731007335 Sodium/calcium exchanger protein; Region: Na_Ca_ex; pfam01699 755731007336 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3666 755731007337 Transposase DDE domain; Region: DDE_Tnp_1_6; pfam13751 755731007338 Major Facilitator Superfamily; Region: MFS_1; pfam07690 755731007339 3-ketoacyl-(acyl-carrier-protein) reductase; Provisional; Region: fabG; PRK05565 755731007340 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 755731007341 NAD(P) binding site [chemical binding]; other site 755731007342 active site 755731007343 Putative intracellular protease/amidase [General function prediction only]; Region: ThiJ; COG0693 755731007344 Type 1 glutamine amidotransferase (GATase1)-like domain; Region: GAT_1; cl00020 755731007345 conserved cys residue [active] 755731007346 CYTH-like Clostridium thermocellum TTM-like subgroup 1; Region: CYTH-like_CthTTM-like_1; cd07891 755731007347 putative active site [active] 755731007348 putative metal binding residues [ion binding]; other site 755731007349 signature motif; other site 755731007350 putative dimer interface [polypeptide binding]; other site 755731007351 putative phosphate binding site [ion binding]; other site 755731007352 Yqey-like protein; Region: YqeY; pfam09424 755731007353 30S ribosomal protein S21; Reviewed; Region: rpsU; PRK00270 755731007354 Protein Kinase C Interacting protein related (PKCI): PKCI and related proteins belong to the ubiquitous HIT family of hydrolases that act on alpha-phosphates of ribonucleotides. The members of this subgroup have a conserved HxHxHxx motif (x is a...; Region: PKCI_related; cd01276 755731007355 nucleotide binding site/active site [active] 755731007356 HIT family signature motif; other site 755731007357 catalytic residue [active] 755731007358 alanyl-tRNA synthetase; Reviewed; Region: alaS; PRK00252 755731007359 Alanyl-tRNA synthetase (AlaRS) class II core catalytic domain. AlaRS is a homodimer. It is responsible for the attachment of alanine to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for ATP-dependent...; Region: AlaRS_core; cd00673 755731007360 motif 1; other site 755731007361 active site 755731007362 motif 2; other site 755731007363 motif 3; other site 755731007364 Threonyl and Alanyl tRNA synthetase second additional domain; Region: tRNA_SAD; smart00863 755731007365 Predicted phosphatases [General function prediction only]; Region: Gph; COG0546 755731007366 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 755731007367 active site 755731007368 motif I; other site 755731007369 motif II; other site 755731007370 Ornithine acetyltransferase (OAT) family; also referred to as ArgJ. OAT catalyzes the first and fifth steps in arginine biosynthesis, coupling acetylation of glutamate with deacetylation of N-acetylornithine, which allows recycling of the acetyl group in...; Region: OAT; cd02152 755731007371 heterotetramer interface [polypeptide binding]; other site 755731007372 active site pocket [active] 755731007373 cleavage site 755731007374 Chemotaxis signal transduction protein [Cell motility and secretion / Signal transduction mechanisms]; Region: CheW; COG0835 755731007375 putative bacteriocin precursor, CLI_3235 family; Region: ocin_CLI_3235; TIGR04065 755731007376 peptide maturation system protein, TIGR04066 family; Region: nat_prod_clost 755731007377 Cys-rich peptide radical SAM maturase CcpM; Region: rSAM_ocin_clost; TIGR04068 755731007378 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 755731007379 FeS/SAM binding site; other site 755731007380 Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer); Region: MA; smart00283 755731007381 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 755731007382 dimer interface [polypeptide binding]; other site 755731007383 putative CheW interface [polypeptide binding]; other site 755731007384 PBP superfamily domain; Region: PBP_like_2; cl17296 755731007385 Predicted flavin-nucleotide-binding protein [General function prediction only]; Region: COG3467 755731007386 ABC-type phosphate transport system, permease component [Inorganic ion transport and metabolism]; Region: PstA; COG0581 755731007387 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 755731007388 dimer interface [polypeptide binding]; other site 755731007389 conserved gate region; other site 755731007390 putative PBP binding loops; other site 755731007391 ABC-ATPase subunit interface; other site 755731007392 ABC-type phosphate transport system, permease component [Inorganic ion transport and metabolism]; Region: PstC; COG0573 755731007393 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 755731007394 dimer interface [polypeptide binding]; other site 755731007395 conserved gate region; other site 755731007396 putative PBP binding loops; other site 755731007397 ABC-ATPase subunit interface; other site 755731007398 ABC-type phosphate transport system, ATPase component [Inorganic ion transport and metabolism]; Region: PstB; COG1117 755731007399 ATP-binding cassette domain of the phosphate transport system; Region: ABC_PstB_phosphate_transporter; cd03260 755731007400 Walker A/P-loop; other site 755731007401 ATP binding site [chemical binding]; other site 755731007402 Q-loop/lid; other site 755731007403 ABC transporter signature motif; other site 755731007404 Walker B; other site 755731007405 D-loop; other site 755731007406 H-loop/switch region; other site 755731007407 phosphate transport system regulatory protein PhoU; Region: phoU_full; TIGR02135 755731007408 PhoU domain; Region: PhoU; pfam01895 755731007409 PhoU domain; Region: PhoU; pfam01895 755731007410 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 755731007411 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 755731007412 active site 755731007413 phosphorylation site [posttranslational modification] 755731007414 intermolecular recognition site; other site 755731007415 dimerization interface [polypeptide binding]; other site 755731007416 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 755731007417 DNA binding site [nucleotide binding] 755731007418 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 755731007419 dimerization interface [polypeptide binding]; other site 755731007420 phosphate regulon sensor kinase PhoR; Region: phoR_proteo; TIGR02966 755731007421 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 755731007422 dimer interface [polypeptide binding]; other site 755731007423 phosphorylation site [posttranslational modification] 755731007424 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 755731007425 ATP binding site [chemical binding]; other site 755731007426 Mg2+ binding site [ion binding]; other site 755731007427 G-X-G motif; other site 755731007428 Cellobiose phosphorylase [Carbohydrate transport and metabolism]; Region: COG3459 755731007429 N-terminal domain of cellobiose phosphorylase (CBP) and similar proteins; Region: GH94N_CBP_like; cd11754 755731007430 catalytic domain interface [polypeptide binding]; other site 755731007431 homodimer interface [polypeptide binding]; other site 755731007432 putative active site [active] 755731007433 ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395 755731007434 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 755731007435 dimer interface [polypeptide binding]; other site 755731007436 conserved gate region; other site 755731007437 putative PBP binding loops; other site 755731007438 ABC-ATPase subunit interface; other site 755731007439 ABC-type spermidine/putrescine transport system, permease component II [Amino acid transport and metabolism]; Region: PotC; COG1177 755731007440 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 755731007441 dimer interface [polypeptide binding]; other site 755731007442 conserved gate region; other site 755731007443 ABC-ATPase subunit interface; other site 755731007444 ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653 755731007445 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; pfam01547 755731007446 Response regulator receiver domain; Region: Response_reg; pfam00072 755731007447 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 755731007448 active site 755731007449 phosphorylation site [posttranslational modification] 755731007450 intermolecular recognition site; other site 755731007451 dimerization interface [polypeptide binding]; other site 755731007452 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 755731007453 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 755731007454 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 755731007455 Predicted signal transduction protein with a C-terminal ATPase domain [Signal transduction mechanisms]; Region: COG2972 755731007456 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 755731007457 dimerization interface [polypeptide binding]; other site 755731007458 Histidine kinase; Region: His_kinase; pfam06580 755731007459 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 755731007460 ATP binding site [chemical binding]; other site 755731007461 Mg2+ binding site [ion binding]; other site 755731007462 G-X-G motif; other site 755731007463 ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653 755731007464 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; pfam01547 755731007465 ATP-binding subunits of Clp protease and DnaK/DnaJ chaperones [Posttranslational modification, protein turnover, chaperones]; Region: clpA; COG0542 755731007466 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 755731007467 Walker A motif; other site 755731007468 ATP binding site [chemical binding]; other site 755731007469 Walker B motif; other site 755731007470 arginine finger; other site 755731007471 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 755731007472 Walker A motif; other site 755731007473 ATP binding site [chemical binding]; other site 755731007474 Walker B motif; other site 755731007475 arginine finger; other site 755731007476 C-terminal, D2-small domain, of ClpB protein; Region: ClpB_D2-small; pfam10431 755731007477 Phosphate/sulphate permeases [Inorganic ion transport and metabolism]; Region: PitA; COG0306 755731007478 Phosphate transport regulator (distant homolog of PhoU) [Inorganic ion transport and metabolism]; Region: COG1392 755731007479 excinuclease ABC subunit A; Reviewed; Region: uvrA; PRK00349 755731007480 ATP-binding cassette domain I of the excision repair protein UvrA; Region: ABC_UvrA_I; cd03270 755731007481 ATP-binding cassette domain I of the excision repair protein UvrA; Region: ABC_UvrA_I; cd03270 755731007482 ATP-binding cassette domain II of the excision repair protein UvrA; Region: ABC_UvrA_II; cd03271 755731007483 Thiamine transporter protein (Thia_YuaJ); Region: Thia_YuaJ; pfam09515 755731007484 Site-specific recombinases, DNA invertase Pin homologs [DNA replication, recombination, and repair]; Region: PinR; COG1961 755731007485 Serine Recombinase family, catalytic domain; a DNA binding domain may be present either N- or C-terminal to the catalytic domain. These enzymes perform site-specific recombination of DNA molecules by a concerted, four-strand cleavage and rejoining...; Region: Ser_Recombinase; cd00338 755731007486 catalytic residues [active] 755731007487 catalytic nucleophile [active] 755731007488 Recombinase; Region: Recombinase; pfam07508 755731007489 Recombinase zinc beta ribbon domain; Region: Zn_ribbon_recom; pfam13408 755731007490 Dockerin type I repeat; Region: Dockerin_1; pfam00404 755731007491 Glycosyl hydrolase family 53; Region: Glyco_hydro_53; cl06672 755731007492 Signal transduction histidine kinase regulating citrate/malate metabolism [Signal transduction mechanisms]; Region: CitA; COG3290 755731007493 Accessory gene regulator B; Region: AgrB; pfam04647 755731007494 Stage IV sporulation protein A (spore_IV_A); Region: Spore_IV_A; pfam09547 755731007495 Bacterial SH3 domain; Region: SH3_3; pfam08239 755731007496 Cell wall-associated hydrolases (invasion-associated proteins) [Cell envelope biogenesis, outer membrane]; Region: Spr; COG0791 755731007497 NlpC/P60 family; Region: NLPC_P60; pfam00877 755731007498 NAD(P)H-dependent glycerol-3-phosphate dehydrogenase; Validated; Region: gpsA; PRK00094 755731007499 NAD-dependent glycerol-3-phosphate dehydrogenase N-terminus; Region: NAD_Gly3P_dh_N; pfam01210 755731007500 NAD-dependent glycerol-3-phosphate dehydrogenase C-terminus; Region: NAD_Gly3P_dh_C; pfam07479 755731007501 putative glycerol-3-phosphate acyltransferase PlsY; Provisional; Region: PRK00220 755731007502 GTP-binding protein Der; Reviewed; Region: PRK00093 755731007503 EngA1 GTPase contains the first domain of EngA; Region: EngA1; cd01894 755731007504 G1 box; other site 755731007505 GTP/Mg2+ binding site [chemical binding]; other site 755731007506 Switch I region; other site 755731007507 G2 box; other site 755731007508 Switch II region; other site 755731007509 G3 box; other site 755731007510 G4 box; other site 755731007511 G5 box; other site 755731007512 EngA2 GTPase contains the second domain of EngA; Region: EngA2; cd01895 755731007513 G1 box; other site 755731007514 GTP/Mg2+ binding site [chemical binding]; other site 755731007515 Switch I region; other site 755731007516 G2 box; other site 755731007517 G3 box; other site 755731007518 Switch II region; other site 755731007519 G4 box; other site 755731007520 G5 box; other site 755731007521 putative FeS-containing Cyanobacterial-specific oxidoreductase; Region: cyano_FeS_chp; TIGR03279 755731007522 PDZ domain, also called DHR (Dlg homologous region) or GLGF (after a conserved sequence motif). Many PDZ domains bind C-terminal polypeptides, though binding to internal (non-C-terminal) polypeptides and even to lipids has been demonstrated; Region: PDZ; cl00117 755731007523 Protein of unknown function (DUF512); Region: DUF512; pfam04459 755731007524 50S ribosomal protein L32; Reviewed; Region: rpmF; PRK12286 755731007525 Uncharacterized ACR, COG1399; Region: DUF177; pfam02620 755731007526 propionate/acetate kinase; Provisional; Region: PRK12379 755731007527 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cd00012 755731007528 nucleotide binding site [chemical binding]; other site 755731007529 butyrate kinase; Provisional; Region: PRK03011 755731007530 phosphotransacetylase; Reviewed; Region: eutD; PRK09653 755731007531 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 755731007532 putative substrate translocation pore; other site 755731007533 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 755731007534 S-adenosylmethionine binding site [chemical binding]; other site 755731007535 glutamyl-tRNA synthetase; Reviewed; Region: gltX; PRK01406 755731007536 catalytic core domain of discriminating glutamyl-tRNA synthetase; Region: GluRS_core; cd00808 755731007537 active site 755731007538 HIGH motif; other site 755731007539 catalytic core domain of discriminating glutamyl-tRNA synthetase; Region: GluRS_core; cd00808 755731007540 active site 755731007541 KMSKS motif; other site 755731007542 cofactor-independent phosphoglycerate mutase; Provisional; Region: PRK04200 755731007543 2,3-bisphosphoglycerate-independent phosphoglycerate mutase; Region: PhosphMutase; cl17294 755731007544 Site-specific recombinases, DNA invertase Pin homologs [DNA replication, recombination, and repair]; Region: PinR; COG1961 755731007545 Serine Recombinase family, catalytic domain; a DNA binding domain may be present either N- or C-terminal to the catalytic domain. These enzymes perform site-specific recombination of DNA molecules by a concerted, four-strand cleavage and rejoining...; Region: Ser_Recombinase; cd00338 755731007546 catalytic residues [active] 755731007547 catalytic nucleophile [active] 755731007548 Recombinase; Region: Recombinase; pfam07508 755731007549 Recombinase zinc beta ribbon domain; Region: Zn_ribbon_recom; pfam13408 755731007550 Fascin-like domain; members include actin-bundling/crosslinking proteins facsin, histoactophilin and singed; identified in sea urchin, Drosophila, Xenopus, rodents, and humans; The fascin-like domain adopts a beta-trefoil topology and contains an...; Region: Fascin; cl00187 755731007551 PKC phosphorylation site [posttranslational modification]; other site 755731007552 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 755731007553 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 755731007554 ATP binding site [chemical binding]; other site 755731007555 Mg2+ binding site [ion binding]; other site 755731007556 G-X-G motif; other site 755731007557 Response regulator receiver domain; Region: Response_reg; pfam00072 755731007558 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 755731007559 active site 755731007560 phosphorylation site [posttranslational modification] 755731007561 intermolecular recognition site; other site 755731007562 dimerization interface [polypeptide binding]; other site 755731007563 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 755731007564 non-specific DNA binding site [nucleotide binding]; other site 755731007565 salt bridge; other site 755731007566 sequence-specific DNA binding site [nucleotide binding]; other site 755731007567 Inclusion body protein; Region: PixA; pfam12306 755731007568 Rhs family protein [Cell envelope biogenesis, outer membrane]; Region: RhsA; COG3209 755731007569 RHS repeat-associated core domain; Region: Rhs_assc_core; TIGR03696 755731007570 Immune inhibitor A peptidase M6; Region: Peptidase_M6; cl11525 755731007571 Rhs family protein [Cell envelope biogenesis, outer membrane]; Region: RhsA; COG3209 755731007572 RHS Repeat; Region: RHS_repeat; cl11982 755731007573 RHS Repeat; Region: RHS_repeat; cl11982 755731007574 RHS repeat-associated core domain; Region: Rhs_assc_core; TIGR03696 755731007575 Putative peptidoglycan binding domain; Region: PG_binding_1; pfam01471 755731007576 Peptidase S8 family domain in Subtilisin-like proteins; Region: Peptidases_S8_Subtilisin_like; cd07473 755731007577 catalytic triad [active] 755731007578 putative active site [active] 755731007579 Rhs family protein [Cell envelope biogenesis, outer membrane]; Region: RhsA; COG3209 755731007580 YD repeat (two copies); Region: YD_repeat_2x; TIGR01643 755731007581 Rhs family protein [Cell envelope biogenesis, outer membrane]; Region: RhsA; COG3209 755731007582 YD repeat (two copies); Region: YD_repeat_2x; TIGR01643 755731007583 Rhs family protein [Cell envelope biogenesis, outer membrane]; Region: RhsA; COG3209 755731007584 Uncharacterized protein conserved in Bacteroidetes; Region: Bacuni_01323_like; cd12871 755731007585 RHS repeat-associated core domain; Region: Rhs_assc_core; TIGR03696 755731007586 mutatrotase, YjhT family; Region: muta_rot_YjhT; TIGR03547 755731007587 Galactose oxidase, central domain; Region: Kelch_3; pfam13415 755731007588 Galactose oxidase, central domain; Region: Kelch_3; pfam13415 755731007589 Kelch motif; Region: Kelch_1; pfam01344 755731007590 Kelch motif; Region: Kelch_1; pfam01344 755731007591 Kelch motif; Region: Kelch_1; pfam01344 755731007592 Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all...; Region: FN3; cd00063 755731007593 Interdomain contacts; other site 755731007594 Cytokine receptor motif; other site 755731007595 Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all...; Region: FN3; cd00063 755731007596 Interdomain contacts; other site 755731007597 Cytokine receptor motif; other site 755731007598 Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all...; Region: FN3; cd00063 755731007599 Interdomain contacts; other site 755731007600 Cytokine receptor motif; other site 755731007601 Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all...; Region: FN3; cd00063 755731007602 Interdomain contacts; other site 755731007603 Cytokine receptor motif; other site 755731007604 Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all...; Region: FN3; cd00063 755731007605 Interdomain contacts; other site 755731007606 Cytokine receptor motif; other site 755731007607 Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all...; Region: FN3; cd00063 755731007608 Interdomain contacts; other site 755731007609 Cytokine receptor motif; other site 755731007610 Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all...; Region: FN3; cd00063 755731007611 Interdomain contacts; other site 755731007612 Cytokine receptor motif; other site 755731007613 Domains similar to the eukaryotic reeler domain and bacterial cohesins; Region: Reeler_cohesin_like; cl14606 755731007614 Site-specific recombinases, DNA invertase Pin homologs [DNA replication, recombination, and repair]; Region: PinR; COG1961 755731007615 Serine Recombinase family, catalytic domain; a DNA binding domain may be present either N- or C-terminal to the catalytic domain. These enzymes perform site-specific recombination of DNA molecules by a concerted, four-strand cleavage and rejoining...; Region: Ser_Recombinase; cl02788 755731007616 catalytic residues [active] 755731007617 catalytic nucleophile [active] 755731007618 Esterases and lipases (includes fungal lipases, cholinesterases, etc.) These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cd00312 755731007619 alpha/beta hydrolase fold; Region: Abhydrolase_3; pfam07859 755731007620 substrate binding pocket [chemical binding]; other site 755731007621 Prolyl oligopeptidase family; Region: Peptidase_S9; pfam00326 755731007622 ABC-2 family transporter protein; Region: ABC2_membrane_2; pfam12679 755731007623 ABC-2 family transporter protein; Region: ABC2_membrane_3; pfam12698 755731007624 ABC-2 family transporter protein; Region: ABC2_membrane_4; pfam12730 755731007625 ABC-2 family transporter protein; Region: ABC2_membrane_2; cl17866 755731007626 ABC-type multidrug transport system, ATPase component [Defense mechanisms]; Region: CcmA; COG1131 755731007627 ATP-binding cassette domain of the drug resistance transporter and related proteins, subfamily A; Region: ABC_DR_subfamily_A; cd03230 755731007628 Walker A/P-loop; other site 755731007629 ATP binding site [chemical binding]; other site 755731007630 Q-loop/lid; other site 755731007631 ABC transporter signature motif; other site 755731007632 Walker B; other site 755731007633 D-loop; other site 755731007634 H-loop/switch region; other site 755731007635 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 755731007636 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 755731007637 Dockerin type I repeat; Region: Dockerin_1; pfam00404 755731007638 Dockerin type I repeat; Region: Dockerin_1; pfam00404 755731007639 Endoglucanase E-like members of the SGNH hydrolase family; Endoglucanase E catalyzes the endohydrolysis of 1,4-beta-glucosidic linkages in cellulose, lichenin and cereal beta-D-glucans; Region: Endoglucanase_E_like; cd01831 755731007640 active site 755731007641 catalytic triad [active] 755731007642 oxyanion hole [active] 755731007643 5-formyltetrahydrofolate cyclo-ligase family; Region: 5-FTHF_cyc-lig; pfam01812 755731007644 5,10-methenyltetrahydrofolate synthetase; Region: MTHFS_bact; TIGR02727 755731007645 N-ethylammeline chlorohydrolase; Provisional; Region: PRK06038 755731007646 TRZ/ATZ family contains enzymes from the atrazine degradation pathway and related hydrolases. Atrazine, a chlorinated herbizide, can be catabolized by a variety of different bacteria. The first three steps of the atrazine dehalogenation pathway are...; Region: ATZ_TRZ_like; cd01298 755731007647 active site 755731007648 putative substrate binding pocket [chemical binding]; other site 755731007649 S-adenosyl-L-homocysteine hydrolase; Provisional; Region: PRK05476 755731007650 S-Adenosylhomocysteine Hydrolase, NAD-binding and catalytic domains; Region: SAHH; cd00401 755731007651 homotetramer interface [polypeptide binding]; other site 755731007652 ligand binding site [chemical binding]; other site 755731007653 catalytic site [active] 755731007654 NAD binding site [chemical binding]; other site 755731007655 Carbohydrate binding domain; Region: CBM_25; smart01066 755731007656 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 755731007657 S-adenosylmethionine binding site [chemical binding]; other site 755731007658 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 755731007659 16S rRNA uridine-516 pseudouridylate synthase and related pseudouridylate synthases [Translation, ribosomal structure and biogenesis]; Region: RsuA; COG1187 755731007660 RNA binding surface [nucleotide binding]; other site 755731007661 Pseudouridine synthase, Escherichia coli RsuA like; Region: PseudoU_synth_RsuA; cd02553 755731007662 active site 755731007663 uracil binding [chemical binding]; other site 755731007664 rRNA (cytosine-C(5)-)-methyltransferase RsmF; Reviewed; Region: yebU; PRK11933 755731007665 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 755731007666 S-adenosylmethionine binding site [chemical binding]; other site 755731007667 pre-rRNA processing and ribosome biogenesis; Region: Nol1_Nop2_Fmu_2; pfam13636 755731007668 RNA polymerase sigma factor, sigma-70 family; Region: sigma70-ECF; TIGR02937 755731007669 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 755731007670 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 755731007671 DNA binding residues [nucleotide binding] 755731007672 Transcriptional regulators [Transcription]; Region: FadR; COG2186 755731007673 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 755731007674 DNA-binding site [nucleotide binding]; DNA binding site 755731007675 FCD domain; Region: FCD; pfam07729 755731007676 aconitate hydratase; Validated; Region: PRK07229 755731007677 Aconitase catalyzes the reversible isomerization of citrate and isocitrate as part of the TCA cycle; Region: AcnA_Bact; cd01585 755731007678 substrate binding site [chemical binding]; other site 755731007679 ligand binding site [chemical binding]; other site 755731007680 Aconitase swivel domain. Aconitase (aconitate hydratase) catalyzes the reversible isomerization of citrate and isocitrate as part of the TCA cycle. This is the aconitase swivel domain, which undergoes swivelling conformational change in the enzyme...; Region: Aconitase_swivel; cl00215 755731007681 substrate binding site [chemical binding]; other site 755731007682 Isopropylmalate/homocitrate/citramalate synthases [Amino acid transport and metabolism]; Region: LeuA; COG0119 755731007683 Clostridium kluyveri Re-citrate synthase and related proteins, catalytic TIM barrel domain; Region: DRE_TIM_Re_CS; cd07947 755731007684 active site 755731007685 catalytic residues [active] 755731007686 metal binding site [ion binding]; metal-binding site 755731007687 Methyl-accepting chemotaxis protein [Cell motility and secretion / Signal transduction mechanisms]; Region: Tar; COG0840 755731007688 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 755731007689 dimer interface [polypeptide binding]; other site 755731007690 putative CheW interface [polypeptide binding]; other site 755731007691 phosphoribosylamine--glycine ligase; Provisional; Region: PRK00885 755731007692 Phosphoribosylglycinamide synthetase, N domain; Region: GARS_N; pfam02844 755731007693 Phosphoribosylglycinamide synthetase, ATP-grasp (A) domain; Region: GARS_A; pfam01071 755731007694 Phosphoribosylglycinamide synthetase, C domain; Region: GARS_C; pfam02843 755731007695 bifunctional phosphoribosylaminoimidazolecarboxamide formyltransferase/IMP cyclohydrolase; Provisional; Region: purH; PRK00881 755731007696 Inosine monophosphate cyclohydrolase domain. This is the N-terminal domain in the purine biosynthesis pathway protein ATIC (purH). The bifunctional ATIC protein contains a C-terminal ATIC formylase domain that formylates...; Region: IMPCH; cd01421 755731007697 purine monophosphate binding site [chemical binding]; other site 755731007698 dimer interface [polypeptide binding]; other site 755731007699 putative catalytic residues [active] 755731007700 AICARFT/IMPCHase bienzyme; Region: AICARFT_IMPCHas; smart00798 755731007701 AICARFT/IMPCHase bienzyme; Region: AICARFT_IMPCHas; cl03362 755731007702 phosphoribosylglycinamide formyltransferase; Reviewed; Region: purN; PRK05647 755731007703 Phosphoribosylglycinamide formyltransferase (GAR transformylase, GART); Region: FMT_core_GART; cd08645 755731007704 active site 755731007705 substrate binding site [chemical binding]; other site 755731007706 cosubstrate binding site; other site 755731007707 catalytic site [active] 755731007708 phosphoribosylaminoimidazole synthetase; Provisional; Region: PRK05385 755731007709 PurM (Aminoimidazole Ribonucleotide [AIR] synthetase), one of eleven enzymes required for purine biosynthesis, catalyzes the conversion of formylglycinamide ribonucleotide (FGAM) and ATP to AIR, ADP, and Pi, the fifth step in de novo purine biosynthesis; Region: PurM; cd02196 755731007710 dimerization interface [polypeptide binding]; other site 755731007711 putative ATP binding site [chemical binding]; other site 755731007712 amidophosphoribosyltransferase; Provisional; Region: PRK05793 755731007713 Glutamine amidotransferases class-II (GN-AT)_GPAT- type. This domain is found at the N-terminus of glutamine phosphoribosylpyrophosphate (Prpp) amidotransferase (GPATase) . The glutaminase domain catalyzes amide nitrogen transfer from glutamine to the...; Region: GPATase_N; cd00715 755731007714 active site 755731007715 tetramer interface [polypeptide binding]; other site 755731007716 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 755731007717 active site 755731007718 AIR carboxylase; Region: AIRC; pfam00731 755731007719 Membrane transport protein; Region: Mem_trans; pfam03547 755731007720 zinc-ribbon domain; Region: zf-ribbon_3; cl11198 755731007721 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 755731007722 sulfate ABC transporter, ATP-binding protein; Region: 3a0106s01; TIGR00968 755731007723 Walker A/P-loop; other site 755731007724 ATP binding site [chemical binding]; other site 755731007725 Q-loop/lid; other site 755731007726 ABC transporter signature motif; other site 755731007727 Walker B; other site 755731007728 D-loop; other site 755731007729 H-loop/switch region; other site 755731007730 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 755731007731 dimer interface [polypeptide binding]; other site 755731007732 ABC-type sulfate transport system, permease component [Posttranslational modification, protein turnover, chaperones]; Region: CysU; COG0555 755731007733 conserved gate region; other site 755731007734 putative PBP binding loops; other site 755731007735 ABC-ATPase subunit interface; other site 755731007736 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; cl17199 755731007737 Bacterial extracellular solute-binding protein; Region: SBP_bac_11; pfam13531 755731007738 Streptomyces rubellomurinus FrbC and related proteins, catalytic TIM barrel domain; Region: DRE_TIM_NifV; cd07939 755731007739 active site 755731007740 catalytic residues [active] 755731007741 metal binding site [ion binding]; metal-binding site 755731007742 trans-homoaconitate synthase; Reviewed; Region: aksA; PRK11858 755731007743 Thioredoxin (TRX)-like [2Fe-2S] Ferredoxin (Fd) family; composed of [2Fe-2S] Fds with a TRX fold (TRX-like Fds) and proteins containing domains similar to TRX-like Fd including formate dehydrogenases, NAD-reducing hydrogenases and the subunit E of NADH:...; Region: TRX_Fd_family; cd02980 755731007744 dimer interface [polypeptide binding]; other site 755731007745 [2Fe-2S] cluster binding site [ion binding]; other site 755731007746 The nitrogenase enzyme system catalyzes the ATP-dependent reduction of dinitrogen to ammonia. This group contains both alpha and beta subunits of component 1 of the three known genetically distinct types of nitrogenase systems: a molybdenum-dependent; Region: Oxidoreductase_nitrogenase; cl02775 755731007747 Nitrogenase component 1 type Oxidoreductase; Region: Oxidored_nitro; pfam00148 755731007748 nitrogenase cofactor biosynthesis protein NifB; Region: nifB; TIGR01290 755731007749 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 755731007750 FeS/SAM binding site; other site 755731007751 NifB belongs to a family of iron-molybdenum cluster-binding proteins that includes NifX, and NifY, all of which are involved in the synthesis of an iron-molybdenum cofactor (FeMo-co) that binds the active site of the dinitrogenase enzyme as part of...; Region: NifB; cd00852 755731007752 nitrogenase molybdenum-iron cofactor biosynthesis protein NifE; Region: nifE; TIGR01283 755731007753 The nitrogenase enzyme system catalyzes the ATP-dependent reduction of dinitrogen to ammonia. This group contains both alpha and beta subunits of component 1 of the three known genetically distinct types of nitrogenase systems: a molybdenum-dependent; Region: Oxidoreductase_nitrogenase; cl02775 755731007754 The nitrogenase enzyme system catalyzes the ATP-dependent reduction of dinitrogen to ammonia. This group contains both alpha and beta subunits of component 1 of the three known genetically distinct types of nitrogenase systems: a molybdenum-dependent; Region: Oxidoreductase_nitrogenase; cl02775 755731007755 Nitrogenase component 1 type Oxidoreductase; Region: Oxidored_nitro; pfam00148 755731007756 The nitrogenase enzyme system catalyzes the ATP-dependent reduction of dinitrogen to ammonia. This group contains both alpha and beta subunits of component 1 of the three known genetically distinct types of nitrogenase systems: a molybdenum-dependent; Region: Oxidoreductase_nitrogenase; cl02775 755731007757 nitrogenase alpha chain; Region: alt_nitrog_alph; TIGR01284 755731007758 Nitrogen regulatory protein P-II; Region: P-II; pfam00543 755731007759 Nitrogen regulatory protein P-II; Region: P-II; smart00938 755731007760 Nitrogen regulatory protein P-II; Region: P-II; pfam00543 755731007761 Nitrogen regulatory protein P-II; Region: P-II; smart00938 755731007762 NifH gene encodes component II (iron protein) of nitrogenase. Nitrogenase is responsible for the biological nitrogen fixation, i.e. reduction of molecular nitrogen to ammonia. NifH consists of two oxygen-sensitive metallosulfur proteins: the...; Region: NifH; cd02040 755731007763 nitrogenase iron protein; Region: nifH; TIGR01287 755731007764 Nucleotide-binding sites [chemical binding]; other site 755731007765 Walker A motif; other site 755731007766 Switch I region of nucleotide binding site; other site 755731007767 Fe4S4 binding sites [ion binding]; other site 755731007768 Switch II region of nucleotide binding site; other site 755731007769 Iron only nitrogenase protein AnfO (AnfO_nitrog); Region: AnfO_nitrog; cl17112 755731007770 2-deoxyribose-5-phosphate aldolase (DERA) of the DeoC family; Region: DeoC; cd00959 755731007771 intersubunit interface [polypeptide binding]; other site 755731007772 active site 755731007773 catalytic residue [active] 755731007774 Pseudomonas avirulence D protein (AvrD); Region: AvrD; pfam05655 755731007775 AAA domain; Region: AAA_28; pfam13521 755731007776 AAA domain; Region: AAA_17; pfam13207 755731007777 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 755731007778 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 755731007779 active site 755731007780 phosphorylation site [posttranslational modification] 755731007781 intermolecular recognition site; other site 755731007782 dimerization interface [polypeptide binding]; other site 755731007783 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 755731007784 DNA binding residues [nucleotide binding] 755731007785 dimerization interface [polypeptide binding]; other site 755731007786 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 755731007787 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 755731007788 ATP binding site [chemical binding]; other site 755731007789 Mg2+ binding site [ion binding]; other site 755731007790 G-X-G motif; other site 755731007791 Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673 755731007792 Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408 755731007793 Oxidoreductase family, C-terminal alpha/beta domain; Region: GFO_IDH_MocA_C; pfam02894 755731007794 Protein of unknown function (DUF3834); Region: DUF3834; pfam12916 755731007795 Nucleoside H+ symporter; Region: Nuc_H_symport; pfam03825 755731007796 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 755731007797 putative substrate translocation pore; other site 755731007798 Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673 755731007799 Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408 755731007800 Putative peptidoglycan-binding domain-containing protein [Cell envelope biogenesis, outer membrane]; Region: COG3409 755731007801 Putative peptidoglycan binding domain; Region: PG_binding_1; pfam01471 755731007802 Putative peptidoglycan binding domain; Region: PG_binding_1; pfam01471 755731007803 Putative peptidoglycan-binding domain-containing protein [Cell envelope biogenesis, outer membrane]; Region: COG3409 755731007804 Putative peptidoglycan binding domain; Region: PG_binding_1; pfam01471 755731007805 Putative peptidoglycan binding domain; Region: PG_binding_1; pfam01471 755731007806 Cell wall-associated hydrolases (invasion-associated proteins) [Cell envelope biogenesis, outer membrane]; Region: Spr; COG0791 755731007807 NlpC/P60 family; Region: NLPC_P60; pfam00877 755731007808 L-idonate 5-dehydrogenase; Region: PLN02702 755731007809 Sorbitol dehydrogenase; Region: sorbitol_DH; cd05285 755731007810 inhibitor binding site; inhibition site 755731007811 catalytic Zn binding site [ion binding]; other site 755731007812 structural Zn binding site [ion binding]; other site 755731007813 NADP binding site [chemical binding]; other site 755731007814 tetramer interface [polypeptide binding]; other site 755731007815 Periplasmic sugar-binding domain of active transport systems that are members of the type I periplasmic binding protein (PBP1) superfamily; Region: PBP1_ABC_sugar_binding_like; cd01536 755731007816 Periplasmic binding protein domain; Region: Peripla_BP_4; pfam13407 755731007817 ligand binding site [chemical binding]; other site 755731007818 Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653 755731007819 Transmembrane subunit (TM) of Escherichia coli AraH and related proteins. E. coli AraH is the TM of a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of the monosaccharide arabinose. This group...; Region: TM_PBP1_transp_AraH_like; cd06579 755731007820 TM-ABC transporter signature motif; other site 755731007821 ABC-type sugar transport system, ATPase component [Carbohydrate transport and metabolism]; Region: MglA; COG1129 755731007822 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 755731007823 Walker A/P-loop; other site 755731007824 ATP binding site [chemical binding]; other site 755731007825 Q-loop/lid; other site 755731007826 ABC transporter signature motif; other site 755731007827 Walker B; other site 755731007828 D-loop; other site 755731007829 H-loop/switch region; other site 755731007830 Second domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_II; cd03215 755731007831 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 755731007832 putative DNA binding site [nucleotide binding]; other site 755731007833 putative Zn2+ binding site [ion binding]; other site 755731007834 Transcriptional regulator/sugar kinase [Transcription / Carbohydrate transport and metabolism]; Region: NagC; COG1940 755731007835 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cd00012 755731007836 nucleotide binding site [chemical binding]; other site 755731007837 DEDDh 3'-5' exonuclease domain of Caenorhabditis elegans ERI-1, human 3' exonuclease, and similar proteins; Region: ERI-1_3'hExo_like; cd06133 755731007838 active site 755731007839 catalytic site [active] 755731007840 substrate binding site [chemical binding]; other site 755731007841 Predicted transcriptional regulators [Transcription]; Region: COG1695 755731007842 Transcriptional regulator PadR-like family; Region: PadR; pfam03551 755731007843 Microcin C7 self-immunity protein determines resistance to exogenous microcin C7; Region: Peptidase_S66_mccF_like; cd07062 755731007844 putative dimer interface [polypeptide binding]; other site 755731007845 catalytic triad [active] 755731007846 Domain of unknown function (DUF4179); Region: DUF4179; pfam13786 755731007847 RNA polymerase sigma factor, sigma-70 family; Region: sigma70-ECF; TIGR02937 755731007848 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 755731007849 Sigma-70, region 4; Region: Sigma70_r4_2; pfam08281 755731007850 DNA binding residues [nucleotide binding] 755731007851 Acetyltransferases, including N-acetylases of ribosomal proteins [Translation, ribosomal structure and biogenesis]; Region: RimL; COG1670 755731007852 Acetyltransferase (GNAT) family; Region: Acetyltransf_1; pfam00583 755731007853 polyketide synthases (PKSs) polymerize simple fatty acids into a large variety of different products, called polyketides, by successive decarboxylating Claisen condensations. PKSs can be divided into 2 groups, modular type I PKSs consisting of one or...; Region: PKS; cd00833 755731007854 Beta-ketoacyl synthase; Region: PKS_KS; smart00825 755731007855 active site 755731007856 malonyl CoA-acyl carrier protein transacylase; Region: fabD; TIGR00128 755731007857 Acyl transferase domain in polyketide synthase (PKS) enzymes; Region: PKS_AT; smart00827 755731007858 ketoreductase (KR), subgroup 2, complex (x) SDRs; Region: KR_2_SDR_x; cd08953 755731007859 This enzymatic domain is part of bacterial polyketide synthases; Region: PKS_KR; smart00822 755731007860 putative NADP binding site [chemical binding]; other site 755731007861 active site 755731007862 Phosphopantetheine attachment site; Region: PP-binding; pfam00550 755731007863 Condensation domain; Region: Condensation; pfam00668 755731007864 Non-ribosomal peptide synthetase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: EntF; COG1020 755731007865 HxxPF-repeated domain; Region: HxxPF_rpt; pfam13745 755731007866 The adenylation domain of nonribosomal peptide synthetases (NRPS); Region: A_NRPS; cd05930 755731007867 acyl-activating enzyme (AAE) consensus motif; other site 755731007868 AMP binding site [chemical binding]; other site 755731007869 Phosphopantetheine attachment site; Region: PP-binding; pfam00550 755731007870 Thioesterase domains of type I polyketide synthases or non-ribosomal peptide synthetases [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG3319 755731007871 Condensation domain; Region: Condensation; pfam00668 755731007872 Non-ribosomal peptide synthetase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: EntF; COG1020 755731007873 The adenylation domain of nonribosomal peptide synthetases (NRPS), including Bacillus subtilis termination module Surfactin (SrfA-C); Region: A_NRPS_Srf_like; cd12117 755731007874 acyl-activating enzyme (AAE) consensus motif; other site 755731007875 AMP binding site [chemical binding]; other site 755731007876 Phosphopantetheine attachment site; Region: PP-binding; pfam00550 755731007877 Condensation domain; Region: Condensation; pfam00668 755731007878 Non-ribosomal peptide synthetase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: EntF; COG1020 755731007879 HxxPF-repeated domain; Region: HxxPF_rpt; pfam13745 755731007880 The adenylation domain of nonribosomal peptide synthetases (NRPS); Region: A_NRPS; cd05930 755731007881 acyl-activating enzyme (AAE) consensus motif; other site 755731007882 AMP binding site [chemical binding]; other site 755731007883 Phosphopantetheine attachment site; Region: PP-binding; pfam00550 755731007884 Condensation domain; Region: Condensation; pfam00668 755731007885 Non-ribosomal peptide synthetase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: EntF; COG1020 755731007886 HxxPF-repeated domain; Region: HxxPF_rpt; pfam13745 755731007887 The adenylation domain of nonribosomal peptide synthetases (NRPS), including Bacillus subtilis termination module Surfactin (SrfA-C); Region: A_NRPS_Srf_like; cd12117 755731007888 acyl-activating enzyme (AAE) consensus motif; other site 755731007889 AMP binding site [chemical binding]; other site 755731007890 Phosphopantetheine attachment site; Region: PP-binding; pfam00550 755731007891 polyketide synthases (PKSs) polymerize simple fatty acids into a large variety of different products, called polyketides, by successive decarboxylating Claisen condensations. PKSs can be divided into 2 groups, modular type I PKSs consisting of one or...; Region: PKS; cd00833 755731007892 Beta-ketoacyl synthase; Region: PKS_KS; smart00825 755731007893 active site 755731007894 malonyl CoA-acyl carrier protein transacylase; Region: fabD; TIGR00128 755731007895 Acyl transferase domain in polyketide synthase (PKS) enzymes; Region: PKS_AT; smart00827 755731007896 ketoreductase (KR), subgroup 2, complex (x) SDRs; Region: KR_2_SDR_x; cd08953 755731007897 putative NADP binding site [chemical binding]; other site 755731007898 This enzymatic domain is part of bacterial polyketide synthases; Region: PKS_KR; smart00822 755731007899 active site 755731007900 Phosphopantetheine attachment site; Region: PP-binding; pfam00550 755731007901 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 755731007902 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 755731007903 active site 755731007904 Acyl carrier protein [Lipid metabolism / Secondary metabolites biosynthesis, transport, and catabolism]; Region: AcpP; COG0236 755731007905 MAEBL; Provisional; Region: PTZ00121 755731007906 GMP synthase; Reviewed; Region: guaA; PRK00074 755731007907 Type 1 glutamine amidotransferase (GATase1) domain found in GMP synthetase; Region: GATase1_GMP_Synthase; cd01742 755731007908 AMP/PPi binding site [chemical binding]; other site 755731007909 candidate oxyanion hole; other site 755731007910 catalytic triad [active] 755731007911 potential glutamine specificity residues [chemical binding]; other site 755731007912 The C-terminal domain of GMP synthetase. It contains two subdomains; the ATP pyrophosphatase domain which closes to the N-termial and the dimerization domain at C-terminal end. The ATP-PPase is a twisted, five-stranded parallel beta-sheet sandwiched...; Region: GMP_synthase_C; cd01997 755731007913 ATP Binding subdomain [chemical binding]; other site 755731007914 Ligand Binding sites [chemical binding]; other site 755731007915 Dimerization subdomain; other site 755731007916 Predicted Fe-S oxidoreductase [General function prediction only]; Region: COG1242 755731007917 Protein of unknown function DUF111; Region: DUF111; pfam01969 755731007918 NCAIR mutase (PurE)-related proteins [General function prediction only]; Region: COG1691 755731007919 AIR carboxylase; Region: AIRC; smart01001 755731007920 peptide chain release factor 2; Validated; Region: prfB; PRK00578 755731007921 PCRF domain; Region: PCRF; pfam03462 755731007922 RF-1 domain; Region: RF-1; pfam00472 755731007923 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 755731007924 haloacid dehalogenase-like hydrolase; Region: Hydrolase_3; pfam08282 755731007925 active site 755731007926 motif I; other site 755731007927 motif II; other site 755731007928 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 755731007929 hypothetical protein; Validated; Region: PRK07682 755731007930 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 755731007931 pyridoxal 5'-phosphate binding site [chemical binding]; other site 755731007932 homodimer interface [polypeptide binding]; other site 755731007933 catalytic residue [active] 755731007934 Winged helix-turn-helix DNA-binding; Region: HTH_24; pfam13412 755731007935 helix_turn_helix ASNC type; Region: HTH_ASNC; smart00344 755731007936 AsnC family; Region: AsnC_trans_reg; pfam01037 755731007937 DivIVA protein; Region: DivIVA; pfam05103 755731007938 TRX family; composed of two groups: Group I, which includes proteins that exclusively encode a TRX domain; and Group II, which are composed of fusion proteins of TRX and additional domains. Group I TRX is a small ancient protein that alter the redox...; Region: TRX_family; cd02947 755731007939 Thioredoxin-like; Region: Thioredoxin_8; pfam13905 755731007940 catalytic residues [active] 755731007941 Exopolysaccharide biosynthesis protein related to N-acetylglucosamine-1-phosphodiester alpha-N-acetylglucosaminidase [Carbohydrate transport and metabolism]; Region: EpsL; COG4632 755731007942 This family is most closely related to the oligosaccharide phosphorylase domain family and other unidentified sequences. Oligosaccharide phosphorylase catalyzes the breakdown of oligosaccharides into glucose-1-phosphate units. They are important...; Region: GT1_Glycogen_Phosphorylase_like; cd04299 755731007943 putative homodimer interface [polypeptide binding]; other site 755731007944 putative active site pocket [active] 755731007945 alpha-glucan phosphorylases; Region: more_P_ylases; TIGR02094 755731007946 Sporulation and spore germination; Region: Germane; cl11253 755731007947 Activator of 2-hydroxyglutaryl-CoA dehydratase (HSP70-class ATPase domain) [Lipid metabolism]; Region: COG1924 755731007948 BadF/BadG/BcrA/BcrD ATPase family; Region: BcrAD_BadFG; cl17271 755731007949 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3581 755731007950 CoA enzyme activase uncharacterized domain (DUF2229); Region: DUF2229; pfam09989 755731007951 Uncharacterized BCR, COG1649; Region: DUF187; pfam02638 755731007952 N-acetylmuramoyl-L-alanine amidase [Cell envelope biogenesis, outer membrane]; Region: AmiC; COG0860 755731007953 N-acetylmuramoyl-L-alanine amidase or MurNAc-LAA (also known as peptidoglycan aminohydrolase, NAMLA amidase, NAMLAA, Amidase 3, and peptidoglycan amidase; EC 3.5.1.28) is an autolysin that hydrolyzes the amide bond between N-acetylmuramoyl and L-amino...; Region: MurNAc-LAA; cd02696 755731007954 active site 755731007955 metal binding site [ion binding]; metal-binding site 755731007956 4Fe-4S binding domain; Region: Fer4_5; pfam12801 755731007957 The HCP family of iron-sulfur proteins includes hybrid cluster protein (HCP), acetyl-CoA synthase (ACS), and carbon monoxide dehydrogenase (CODH), all of which contain [Fe4-S4] metal clusters at their active sites. These proteins have a conserved...; Region: HCP_like; cl14655 755731007958 4Fe-4S dicluster domain; Region: Fer4_10; pfam13237 755731007959 Predicted transcriptional regulators [Transcription]; Region: COG1695 755731007960 Transcriptional regulator PadR-like family; Region: PadR; pfam03551 755731007961 Virulence activator alpha C-term; Region: Vir_act_alpha_C; pfam10400 755731007962 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3666 755731007963 Transposase DDE domain; Region: DDE_Tnp_1_6; pfam13751 755731007964 fructose-bisphosphate aldolase; Provisional; Region: PRK09197 755731007965 Tagatose-1,6-bisphosphate (TBP) aldolase and related Type B Class II aldolases. TBP aldolase is a tetrameric class II aldolase that catalyzes the reversible condensation of dihydroxyacetone phosphate with glyceraldehyde 3-phsophate to produce tagatose 1; Region: TBP_aldolase_IIB; cd00947 755731007966 intersubunit interface [polypeptide binding]; other site 755731007967 active site 755731007968 zinc binding site [ion binding]; other site 755731007969 Na+ binding site [ion binding]; other site 755731007970 6-phosphofructokinase; Provisional; Region: PRK14072 755731007971 6-phosphofructokinase; Region: PFKA_ATP; TIGR02482 755731007972 active site 755731007973 ADP/pyrophosphate binding site [chemical binding]; other site 755731007974 dimerization interface [polypeptide binding]; other site 755731007975 allosteric effector site; other site 755731007976 fructose-1,6-bisphosphate binding site; other site 755731007977 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 755731007978 ATP binding site [chemical binding]; other site 755731007979 Mg2+ binding site [ion binding]; other site 755731007980 G-X-G motif; other site 755731007981 Membrane-bound serine protease (ClpP class) [Posttranslational modification, protein turnover, chaperones]; Region: NfeD; COG1030 755731007982 hypothetical protein; Provisional; Region: PRK13665 755731007983 Response regulator of the LytR/AlgR family [Transcription / Signal transduction mechanisms]; Region: LytT; COG3279 755731007984 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 755731007985 active site 755731007986 phosphorylation site [posttranslational modification] 755731007987 intermolecular recognition site; other site 755731007988 dimerization interface [polypeptide binding]; other site 755731007989 LytTr DNA-binding domain; Region: LytTR; smart00850 755731007990 HD domain; Region: HD_3; pfam13023 755731007991 Acetyltransferases, including N-acetylases of ribosomal proteins [Translation, ribosomal structure and biogenesis]; Region: RimL; COG1670 755731007992 Acetyltransferase (GNAT) family; Region: Acetyltransf_1; pfam00583 755731007993 formate acetyltransferase 1; Region: pyr_form_ly_1; TIGR01255 755731007994 Ribonucleotide reductase and Pyruvate formate lyase; Region: RNR_PFL; cl09939 755731007995 Conserved protein/domain typically associated with flavoprotein oxygenases, DIM6/NTAB family [General function prediction only]; Region: COG1853 755731007996 N-terminal Early set domain associated with the catalytic domain of cellulase; Region: E_set_Cellulase_N; cd02850 755731007997 Glycosyl hydrolase family 9; Region: Glyco_hydro_9; cl02959 755731007998 Platelet-activating factor acetylhydrolase, isoform II; Region: PAF-AH_p_II; pfam03403 755731007999 Prolyl oligopeptidase family; Region: Peptidase_S9; pfam00326 755731008000 Predicted oxidoreductases of the aldo/keto reductase family [General function prediction only]; Region: COG1453 755731008001 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 755731008002 active site 755731008003 catalytic tetrad [active] 755731008004 bidirectional hydrogenase complex protein HoxU; Validated; Region: PRK07569 755731008005 2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207 755731008006 catalytic loop [active] 755731008007 iron binding site [ion binding]; other site 755731008008 NADH-ubiquinone oxidoreductase-G iron-sulfur binding region; Region: NADH-G_4Fe-4S_3; pfam10588 755731008009 [FeFe] hydrogenase, group A; Region: FeFe_hydrog_A; TIGR02512 755731008010 Iron only hydrogenase large subunit, C-terminal domain; Region: Fe_hyd_lg_C; pfam02906 755731008011 Iron hydrogenase small subunit; Region: Fe_hyd_SSU; pfam02256 755731008012 Thioredoxin (TRX)-like [2Fe-2S] Ferredoxin (Fd) family; composed of [2Fe-2S] Fds with a TRX fold (TRX-like Fds) and proteins containing domains similar to TRX-like Fd including formate dehydrogenases, NAD-reducing hydrogenases and the subunit E of NADH:...; Region: TRX_Fd_family; cd02980 755731008013 dimer interface [polypeptide binding]; other site 755731008014 [2Fe-2S] cluster binding site [ion binding]; other site 755731008015 NADH:ubiquinone oxidoreductase, NADH-binding (51 kD) subunit [Energy production and conversion]; Region: NuoF; COG1894 755731008016 SLBB domain; Region: SLBB; pfam10531 755731008017 NADH-ubiquinone oxidoreductase-F iron-sulfur binding region; Region: NADH_4Fe-4S; pfam10589 755731008018 RPB11 and RPB3 subunits of RNA polymerase; Region: RNAP_RPB11_RPB3; cl11409 755731008019 4Fe-4S dicluster domain; Region: Fer4_7; pfam12838 755731008020 Thioredoxin (TRX)-like [2Fe-2S] Ferredoxin (Fd) family; composed of [2Fe-2S] Fds with a TRX fold (TRX-like Fds) and proteins containing domains similar to TRX-like Fd including formate dehydrogenases, NAD-reducing hydrogenases and the subunit E of NADH:...; Region: TRX_Fd_family; cd02980 755731008021 dimer interface [polypeptide binding]; other site 755731008022 [2Fe-2S] cluster binding site [ion binding]; other site 755731008023 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 755731008024 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 755731008025 ATP binding site [chemical binding]; other site 755731008026 Mg2+ binding site [ion binding]; other site 755731008027 G-X-G motif; other site 755731008028 Respiratory-chain NADH dehydrogenase 24 Kd subunit; Region: Complex1_24kDa; pfam01257 755731008029 TRX-like [2Fe-2S] Ferredoxin (Fd) family, NADH:ubiquinone oxidoreductase (Nuo) subunit E subfamily; Nuo, also called respiratory chain Complex 1, is the entry point for electrons into the respiratory chains of bacteria and the mitochondria of eukaryotes; Region: TRX_Fd_NuoE; cd03064 755731008030 putative dimer interface [polypeptide binding]; other site 755731008031 [2Fe-2S] cluster binding site [ion binding]; other site 755731008032 Cache domain; Region: Cache_1; pfam02743 755731008033 Methyl-accepting chemotaxis protein [Cell motility and secretion / Signal transduction mechanisms]; Region: Tar; COG0840 755731008034 HAMP domain; Region: HAMP; pfam00672 755731008035 dimerization interface [polypeptide binding]; other site 755731008036 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 755731008037 dimer interface [polypeptide binding]; other site 755731008038 putative CheW interface [polypeptide binding]; other site 755731008039 Uncharacterized protein family (UPF0081); Region: UPF0081; pfam03652 755731008040 hypothetical protein; Provisional; Region: PRK05473 755731008041 2-methylthioadenine synthetase [Translation, ribosomal structure and biogenesis]; Region: MiaB; COG0621 755731008042 Uncharacterized protein family UPF0004; Region: UPF0004; pfam00919 755731008043 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 755731008044 FeS/SAM binding site; other site 755731008045 Amb_all domain; Region: Amb_all; smart00656 755731008046 Right handed beta helix region; Region: Beta_helix; pfam13229 755731008047 Glycosyltransferase like family 2; Region: Glyco_tranf_2_3; pfam13641 755731008048 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394 755731008049 active site 755731008050 Histidine-containing phosphocarrier protein (HPr)-like proteins. HPr is a central component of the bacterial phosphoenolpyruvate sugar phosphotransferase system (PTS). The PTS catalyses the phosphorylation of sugar substrates during their translocation...; Region: PTS-HPr_like; cd00367 755731008051 regulatory protein interface [polypeptide binding]; other site 755731008052 regulatory phosphorylation site [posttranslational modification]; other site 755731008053 Protein of unknown function (DUF523); Region: DUF523; pfam04463 755731008054 ribonuclease R; Region: RNase_R; TIGR02063 755731008055 Ribonuclease B OB domain; Region: OB_RNB; pfam08206 755731008056 S1_like: Ribosomal protein S1-like RNA-binding domain. Found in a wide variety of RNA-associated proteins. Originally identified in S1 ribosomal protein. This superfamily also contains the Cold Shock Domain (CSD), which is a homolog of the S1 domain; Region: S1_like; cl09927 755731008057 RNB domain; Region: RNB; pfam00773 755731008058 S1_RNase_R: RNase R C-terminal S1 domain. RNase R is a processive 3' to 5' exoribonuclease, which is a homolog of RNase II. RNase R degrades RNA with secondary structure having a 3' overhang of at least 7 nucleotides. RNase R and PNPase...; Region: S1_RNase_R; cd04471 755731008059 RNA binding site [nucleotide binding]; other site 755731008060 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 755731008061 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 755731008062 dimerization interface [polypeptide binding]; other site 755731008063 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 755731008064 dimer interface [polypeptide binding]; other site 755731008065 phosphorylation site [posttranslational modification] 755731008066 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 755731008067 ATP binding site [chemical binding]; other site 755731008068 Mg2+ binding site [ion binding]; other site 755731008069 G-X-G motif; other site 755731008070 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 755731008071 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 755731008072 active site 755731008073 phosphorylation site [posttranslational modification] 755731008074 intermolecular recognition site; other site 755731008075 dimerization interface [polypeptide binding]; other site 755731008076 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 755731008077 DNA binding site [nucleotide binding] 755731008078 Predicted xylanase/chitin deacetylase [Carbohydrate transport and metabolism]; Region: CDA1; COG0726 755731008079 Catalytic NodB homology domain of the carbohydrate esterase 4 superfamily; Region: CE4_SF; cl15692 755731008080 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cl17215 755731008081 Preprotein translocase SecG subunit; Region: SecG; pfam03840 755731008082 enolase; Provisional; Region: eno; PRK00077 755731008083 Enolase: Enolases are homodimeric enzymes that catalyse the reversible dehydration of 2-phospho-D-glycerate to phosphoenolpyruvate as part of the glycolytic and gluconeogenesis pathways. The reaction is facilitated by the presence of metal ions; Region: enolase; cd03313 755731008084 dimer interface [polypeptide binding]; other site 755731008085 metal binding site [ion binding]; metal-binding site 755731008086 substrate binding pocket [chemical binding]; other site 755731008087 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 755731008088 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 755731008089 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 755731008090 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 755731008091 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 755731008092 sequence-specific DNA binding site [nucleotide binding]; other site 755731008093 salt bridge; other site 755731008094 Phosphoglyceromutase [Carbohydrate transport and metabolism]; Region: GpmI; COG0696 755731008095 phosphoglyceromutase; Provisional; Region: PRK05434 755731008096 bifunctional phosphoglycerate kinase/triosephosphate isomerase; Provisional; Region: PRK13962 755731008097 Phosphoglycerate kinase (PGK) is a monomeric enzyme which catalyzes the transfer of the high-energy phosphate group of 1,3-bisphosphoglycerate to ADP, forming ATP and 3-phosphoglycerate. This reaction represents the first of the two substrate-level...; Region: Phosphoglycerate_kinase; cd00318 755731008098 substrate binding site [chemical binding]; other site 755731008099 hinge regions; other site 755731008100 ADP binding site [chemical binding]; other site 755731008101 catalytic site [active] 755731008102 Triosephosphate isomerase (TIM) is a glycolytic enzyme that catalyzes the interconversion of dihydroxyacetone phosphate and D-glyceraldehyde-3-phosphate. The reaction is very efficient and requires neither cofactors nor metal ions. TIM, usually...; Region: TIM; cd00311 755731008103 substrate binding site [chemical binding]; other site 755731008104 dimer interface [polypeptide binding]; other site 755731008105 catalytic triad [active] 755731008106 Pentapeptide repeats (9 copies); Region: Pentapeptide_4; pfam13599 755731008107 Pentapeptide repeats (9 copies); Region: Pentapeptide_4; pfam13599 755731008108 Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805 755731008109 Pentapeptide repeats (9 copies); Region: Pentapeptide_4; pfam13599 755731008110 type I secretion membrane fusion protein, HlyD family; Region: type_I_hlyD; TIGR01843 755731008111 HlyD family secretion protein; Region: HlyD_3; pfam13437 755731008112 ABC-type bacteriocin/lantibiotic exporters, contain an N-terminal double-glycine peptidase domain [Defense mechanisms]; Region: SunT; COG2274 755731008113 A sub-family of peptidase family C39. Peptidase family C39 mostly contains bacteriocin-processing endopeptidases from bacteria. The cysteine peptidases in family C39 cleave the "double-glycine" leader peptides from the precursors of various...; Region: Peptidase_C39B; cd02418 755731008114 putative active site [active] 755731008115 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 755731008116 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 755731008117 Walker A/P-loop; other site 755731008118 ATP binding site [chemical binding]; other site 755731008119 Q-loop/lid; other site 755731008120 ABC transporter signature motif; other site 755731008121 Walker B; other site 755731008122 D-loop; other site 755731008123 H-loop/switch region; other site 755731008124 Predicted signal transduction protein with a C-terminal ATPase domain [Signal transduction mechanisms]; Region: COG2972 755731008125 Spectrin repeats, found in several proteins involved in cytoskeletal structure; family members include spectrin, alpha-actinin and dystrophin; the spectrin repeat forms a three helix bundle with the second helix interrupted by proline in some sequences; Region: SPEC; cl02488 755731008126 linker region; other site 755731008127 Response regulator of the LytR/AlgR family [Transcription / Signal transduction mechanisms]; Region: LytT; COG3279 755731008128 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 755731008129 active site 755731008130 phosphorylation site [posttranslational modification] 755731008131 intermolecular recognition site; other site 755731008132 dimerization interface [polypeptide binding]; other site 755731008133 LytTr DNA-binding domain; Region: LytTR; pfam04397 755731008134 preprotein translocase subunit SecA; Reviewed; Region: PRK09200 755731008135 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 755731008136 ATP binding site [chemical binding]; other site 755731008137 putative Mg++ binding site [ion binding]; other site 755731008138 SecA preprotein cross-linking domain; Region: SecA_PP_bind; pfam01043 755731008139 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cl17351 755731008140 nucleotide binding region [chemical binding]; other site 755731008141 ATP-binding site [chemical binding]; other site 755731008142 galactokinase; Provisional; Region: PRK05322 755731008143 Galactokinase galactose-binding signature; Region: GalKase_gal_bdg; pfam10509 755731008144 GHMP kinases N terminal domain; Region: GHMP_kinases_N; pfam00288 755731008145 GHMP kinases C terminal; Region: GHMP_kinases_C; pfam08544 755731008146 galactose-1-phosphate uridylyltransferase; Provisional; Region: PRK05270 755731008147 Galactose-1-phosphate uridyl transferase, N-terminal domain; Region: GalP_UDP_transf; pfam01087 755731008148 Galactose-1-phosphate uridyl transferase, C-terminal domain; Region: GalP_UDP_tr_C; pfam02744 755731008149 trans-2-enoyl-CoA reductase; Provisional; Region: PRK13656 755731008150 NAD(P)H binding domain of trans-2-enoyl-CoA reductase; Region: Eno-Rase_NADH_b; pfam12242 755731008151 Trans-2-enoyl-CoA reductase catalytic region; Region: Enoyl_reductase; pfam12241 755731008152 Enoyl reductase FAD binding domain; Region: Eno-Rase_FAD_bd; pfam07055 755731008153 glyceraldehyde-3-phosphate dehydrogenase; Provisional; Region: PTZ00023 755731008154 Glyceraldehyde 3-phosphate dehydrogenase, NAD binding domain; Region: Gp_dh_N; pfam00044 755731008155 Glyceraldehyde 3-phosphate dehydrogenase, C-terminal domain; Region: Gp_dh_C; pfam02800 755731008156 Uncharacterized conserved protein (DUF2156); Region: DUF2156; cl12090 755731008157 M20 Peptidase T like enzymes specifically cleave tripeptides; Region: M20_peptT_like; cd05683 755731008158 peptidase T-like protein; Region: PepT-like; TIGR01883 755731008159 metal binding site [ion binding]; metal-binding site 755731008160 putative dimer interface [polypeptide binding]; other site 755731008161 Predicted rRNA methylase (SpoU class) [Translation, ribosomal structure and biogenesis]; Region: CspR; COG0219 755731008162 Predicted inhibitor of MCP methylation, homolog of CheC [Cell motility and secretion]; Region: COG1406 755731008163 Chemotaxis phosphatase CheX; Region: CheX; pfam13690 755731008164 SpoVA protein; Region: SpoVA; pfam03862 755731008165 stage V sporulation protein AD; Validated; Region: PRK08304 755731008166 stage V sporulation protein AD; Provisional; Region: PRK12404 755731008167 SpoVA protein; Region: SpoVA; cl04298 755731008168 sporulation sigma factor SigF; Validated; Region: PRK05572 755731008169 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 755731008170 Sigma-70 region 3; Region: Sigma70_r3; pfam04539 755731008171 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 755731008172 DNA binding residues [nucleotide binding] 755731008173 Anti-sigma regulatory factor (Ser/Thr protein kinase) [Signal transduction mechanisms]; Region: RsbW; COG2172 755731008174 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 755731008175 ATP binding site [chemical binding]; other site 755731008176 Mg2+ binding site [ion binding]; other site 755731008177 G-X-G motif; other site 755731008178 Sulphate Transporter and Anti-Sigma factor antagonist) domain of anti-anti-sigma factors, key regulators of anti-sigma factors by phosphorylation; Region: STAS_anti-anti-sigma_factors; cd07043 755731008179 anti sigma factor interaction site; other site 755731008180 regulatory phosphorylation site [posttranslational modification]; other site 755731008181 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG1481 755731008182 Sporulation Regulator WhiA N terminal; Region: WhiA_N; pfam10298 755731008183 Glycogen debranching enzyme N terminal; Region: GDE_N; pfam12439 755731008184 glycogen debranching enzyme, archaeal type, putative; Region: gde_arch; TIGR01561 755731008185 Amylo-alpha-1,6-glucosidase; Region: GDE_C; pfam06202 755731008186 conserved hypothetical protein, cofD-related; Region: CofD_related; TIGR01826 755731008187 family of mostly uncharacterized proteins similar to B.subtilis YvcK; Region: YvcK_like; cd07187 755731008188 phosphate binding site [ion binding]; other site 755731008189 putative substrate binding pocket [chemical binding]; other site 755731008190 dimer interface [polypeptide binding]; other site 755731008191 glmZ(sRNA)-inactivating NTPase; Provisional; Region: PRK05416 755731008192 shikimate kinase; Provisional; Region: PRK13947 755731008193 UDP-N-acetylenolpyruvoylglucosamine reductase; Provisional; Region: murB; PRK13905 755731008194 FAD binding domain; Region: FAD_binding_4; pfam01565 755731008195 UDP-N-acetylenolpyruvoylglucosamine reductase, C-terminal domain; Region: MurB_C; pfam02873 755731008196 putative hydrolase; Validated; Region: PRK09248 755731008197 Polymerase and Histidinol Phosphatase domain of Ycdx like; Region: PHP_HisPPase_Ycdx_like; cd07437 755731008198 active site 755731008199 HPr Serine kinase N terminus; Region: Hpr_kinase_N; pfam02603 755731008200 Hpr(Ser) kinase/phosphatase; Region: hpr-ser; TIGR00679 755731008201 HprK/P, the bifunctional histidine-containing protein kinase/phosphatase, controls the phosphorylation state of the phosphocarrier protein HPr and regulates the utilization of carbon sources by gram-positive bacteria. It catalyzes both the ATP-dependent...; Region: HprK_C; cd01918 755731008202 Hpr binding site; other site 755731008203 active site 755731008204 homohexamer subunit interaction site [polypeptide binding]; other site 755731008205 H(+) -translocating inorganic pyrophosphatase; Region: PLN02255; cl11452 755731008206 membrane-bound proton-translocating pyrophosphatase; Validated; Region: hppA; PRK00733 755731008207 Protein of unknown function (DUF554); Region: DUF554; pfam04474 755731008208 tRNA nucleotidyltransferase/poly(A) polymerase [Translation, ribosomal structure and biogenesis]; Region: PcnB; COG0617 755731008209 Nucleotidyltransferase (NT) domain of ClassII CCA-adding enzymes; Region: NT_ClassII-CCAase; cd05398 755731008210 active site 755731008211 NTP binding site [chemical binding]; other site 755731008212 metal binding triad [ion binding]; metal-binding site 755731008213 Probable RNA and SrmB- binding site of polymerase A; Region: PolyA_pol_RNAbd; pfam12627 755731008214 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 755731008215 Zn2+ binding site [ion binding]; other site 755731008216 Mg2+ binding site [ion binding]; other site 755731008217 Integral membrane protein TerC family; Region: TerC; cl10468 755731008218 Putative transposase DNA-binding domain; Region: OrfB_Zn_ribbon; pfam07282 755731008219 Stage II sporulation protein E (SpoIIE); Region: SpoIIE; pfam07228 755731008220 4Fe-4S binding domain; Region: Fer4_6; pfam12837 755731008221 [FeFe] hydrogenase, group A; Region: FeFe_hydrog_A; TIGR02512 755731008222 Iron only hydrogenase large subunit, C-terminal domain; Region: Fe_hyd_lg_C; pfam02906 755731008223 Putative Fe-S cluster; Region: FeS; cl17515 755731008224 PAS domain S-box; Region: sensory_box; TIGR00229 755731008225 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 755731008226 putative active site [active] 755731008227 Thioredoxin (TRX)-like [2Fe-2S] Ferredoxin (Fd) family; composed of [2Fe-2S] Fds with a TRX fold (TRX-like Fds) and proteins containing domains similar to TRX-like Fd including formate dehydrogenases, NAD-reducing hydrogenases and the subunit E of NADH:...; Region: TRX_Fd_family; cd02980 755731008228 dimer interface [polypeptide binding]; other site 755731008229 [2Fe-2S] cluster binding site [ion binding]; other site 755731008230 2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207 755731008231 catalytic loop [active] 755731008232 iron binding site [ion binding]; other site 755731008233 NADH-ubiquinone oxidoreductase-G iron-sulfur binding region; Region: NADH-G_4Fe-4S_3; pfam10588 755731008234 The HCP family of iron-sulfur proteins includes hybrid cluster protein (HCP), acetyl-CoA synthase (ACS), and carbon monoxide dehydrogenase (CODH), all of which contain [Fe4-S4] metal clusters at their active sites. These proteins have a conserved...; Region: HCP_like; cl14655 755731008235 [FeFe] hydrogenase, group A; Region: FeFe_hydrog_A; TIGR02512 755731008236 Iron only hydrogenase large subunit, C-terminal domain; Region: Fe_hyd_lg_C; pfam02906 755731008237 Iron hydrogenase small subunit; Region: Fe_hyd_SSU; pfam02256 755731008238 Thioredoxin (TRX)-like [2Fe-2S] Ferredoxin (Fd) family; composed of [2Fe-2S] Fds with a TRX fold (TRX-like Fds) and proteins containing domains similar to TRX-like Fd including formate dehydrogenases, NAD-reducing hydrogenases and the subunit E of NADH:...; Region: TRX_Fd_family; cd02980 755731008239 dimer interface [polypeptide binding]; other site 755731008240 [2Fe-2S] cluster binding site [ion binding]; other site 755731008241 NADH:ubiquinone oxidoreductase, NADH-binding (51 kD) subunit [Energy production and conversion]; Region: NuoF; COG1894 755731008242 SLBB domain; Region: SLBB; pfam10531 755731008243 NADH-ubiquinone oxidoreductase-F iron-sulfur binding region; Region: NADH_4Fe-4S; pfam10589 755731008244 4Fe-4S binding domain; Region: Fer4_6; pfam12837 755731008245 4Fe-4S dicluster domain; Region: Fer4_10; pfam13237 755731008246 4Fe-4S binding domain; Region: Fer4; pfam00037 755731008247 Respiratory-chain NADH dehydrogenase 24 Kd subunit; Region: Complex1_24kDa; pfam01257 755731008248 TRX-like [2Fe-2S] Ferredoxin (Fd) family, NADH:ubiquinone oxidoreductase (Nuo) subunit E subfamily; Nuo, also called respiratory chain Complex 1, is the entry point for electrons into the respiratory chains of bacteria and the mitochondria of eukaryotes; Region: TRX_Fd_NuoE; cd03064 755731008249 putative dimer interface [polypeptide binding]; other site 755731008250 [2Fe-2S] cluster binding site [ion binding]; other site 755731008251 Predicted oxidoreductases of the aldo/keto reductase family [General function prediction only]; Region: COG1453 755731008252 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 755731008253 active site 755731008254 catalytic tetrad [active] 755731008255 The HCP family of iron-sulfur proteins includes hybrid cluster protein (HCP), acetyl-CoA synthase (ACS), and carbon monoxide dehydrogenase (CODH), all of which contain [Fe4-S4] metal clusters at their active sites. These proteins have a conserved...; Region: HCP_like; cl14655 755731008256 Protein of unknown function DUF45; Region: DUF45; pfam01863 755731008257 Protein of unknown function (DUF1113); Region: DUF1113; pfam06541 755731008258 Arsenate Reductase (ArsC) family; composed of TRX-fold arsenic reductases and similar proteins including the transcriptional regulator, Spx. ArsC catalyzes the reduction of arsenate [As(V)] to arsenite [As(III)], using reducing equivalents derived from...; Region: ArsC_family; cd02977 755731008259 ArsC family; Region: ArsC; pfam03960 755731008260 catalytic residue [active] 755731008261 chemotaxis-specific methylesterase; Provisional; Region: PRK00742 755731008262 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 755731008263 active site 755731008264 phosphorylation site [posttranslational modification] 755731008265 intermolecular recognition site; other site 755731008266 dimerization interface [polypeptide binding]; other site 755731008267 CheB methylesterase; Region: CheB_methylest; pfam01339 755731008268 Domain of Unknown Function (DUF1540); Region: DUF1540; pfam07561 755731008269 CheR methyltransferase, all-alpha domain; Region: CheR_N; pfam03705 755731008270 Methylase of chemotaxis methyl-accepting proteins [Cell motility and secretion / Signal transduction mechanisms]; Region: CheR; COG1352 755731008271 CheR methyltransferase, SAM binding domain; Region: CheR; pfam01739 755731008272 Four helix bundle sensory module for signal transduction; Region: 4HB_MCP_1; pfam12729 755731008273 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 755731008274 dimerization interface [polypeptide binding]; other site 755731008275 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 755731008276 dimer interface [polypeptide binding]; other site 755731008277 putative CheW interface [polypeptide binding]; other site 755731008278 CheW, a small regulator protein, unique to the chemotaxis signalling in prokaryotes and archea. CheW interacts with the histidine kinase CheA, most likely with the related regulatory domain of CheA. CheW is proposed to form signalling arrays together...; Region: CheW; cd00732 755731008279 putative CheA interaction surface; other site 755731008280 Chemotaxis protein histidine kinase and related kinases [Cell motility and secretion / Signal transduction mechanisms]; Region: CheA; COG0643 755731008281 Histidine Phosphotransfer domain, involved in signalling through a two part component systems in which an autophosphorylating histidine protein kinase serves as a phosphoryl donor to a response regulator protein; the response regulator protein is...; Region: HPT; cd00088 755731008282 putative binding surface; other site 755731008283 active site 755731008284 P2 response regulator binding domain; Region: P2; pfam07194 755731008285 Signal transducing histidine kinase, homodimeric domain; Region: H-kinase_dim; pfam02895 755731008286 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 755731008287 ATP binding site [chemical binding]; other site 755731008288 Mg2+ binding site [ion binding]; other site 755731008289 G-X-G motif; other site 755731008290 CheA regulatory domain; CheA is a histidine protein kinase present in bacteria and archea. Activated by the chemotaxis receptor a histidine phosphoryl group from CheA is passed directly to an aspartate in the response regulator CheY. This signalling...; Region: CheA_reg; cd00731 755731008291 FOG: CheY-like receiver [Signal transduction mechanisms]; Region: CheY; COG0784 755731008292 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 755731008293 active site 755731008294 phosphorylation site [posttranslational modification] 755731008295 intermolecular recognition site; other site 755731008296 dimerization interface [polypeptide binding]; other site 755731008297 Uncharacterized flavoproteins [Energy production and conversion]; Region: FpaA; COG0426 755731008298 Metallo-beta-lactamase superfamily; Region: Lactamase_B; smart00849 755731008299 PilZ domain; Region: PilZ; pfam07238 755731008300 5TMR of 5TMR-LYT; Region: 5TM-5TMR_LYT; pfam07694 755731008301 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 755731008302 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 755731008303 metal binding site [ion binding]; metal-binding site 755731008304 active site 755731008305 I-site; other site 755731008306 Carbohydrate binding domain; Region: CBM_4_9; pfam02018 755731008307 Glycosyl hydrolase family 10; Region: Glyco_hydro_10; pfam00331 755731008308 DOMON-like type 9 carbohydrate binding module of xylanases; Region: CBM9_like_1; cd00005 755731008309 Ca binding site [ion binding]; other site 755731008310 carbohydrate binding site [chemical binding]; other site 755731008311 S-layer homology domain; Region: SLH; pfam00395 755731008312 S-layer homology domain; Region: SLH; pfam00395 755731008313 S-layer homology domain; Region: SLH; pfam00395 755731008314 Carbohydrate binding domain; Region: CBM_4_9; pfam02018 755731008315 Carbohydrate binding domain; Region: CBM_4_9; pfam02018 755731008316 Glycosyl hydrolase family 10; Region: Glyco_hydro_10; pfam00331 755731008317 DOMON-like type 9 carbohydrate binding module of xylanases; Region: CBM9_like_1; cd00005 755731008318 Ca binding site [ion binding]; other site 755731008319 carbohydrate binding site [chemical binding]; other site 755731008320 S-layer homology domain; Region: SLH; pfam00395 755731008321 S-layer homology domain; Region: SLH; pfam00395 755731008322 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 755731008323 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 755731008324 dimer interface [polypeptide binding]; other site 755731008325 phosphorylation site [posttranslational modification] 755731008326 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 755731008327 ATP binding site [chemical binding]; other site 755731008328 Mg2+ binding site [ion binding]; other site 755731008329 G-X-G motif; other site 755731008330 ABC-type multidrug transport system, ATPase component [Defense mechanisms]; Region: CcmA; COG1131 755731008331 ATP-binding cassette domain of the bacitracin-resistance transporter; Region: ABC_BcrA_bacitracin_resist; cd03268 755731008332 Walker A/P-loop; other site 755731008333 ATP binding site [chemical binding]; other site 755731008334 Q-loop/lid; other site 755731008335 ABC transporter signature motif; other site 755731008336 Walker B; other site 755731008337 D-loop; other site 755731008338 H-loop/switch region; other site 755731008339 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 755731008340 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 755731008341 active site 755731008342 phosphorylation site [posttranslational modification] 755731008343 intermolecular recognition site; other site 755731008344 dimerization interface [polypeptide binding]; other site 755731008345 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 755731008346 DNA binding site [nucleotide binding] 755731008347 This family includes the Gtfs, a group of homologous glycosyltransferases involved in the final stages of the biosynthesis of antibiotics vancomycin and related chloroeremomycin. Gtfs transfer sugar moieties from an activated NDP-sugar donor to the...; Region: GT1_Gtf_like; cd03784 755731008348 glycosyltransferase, MGT family; Region: MGT; TIGR01426 755731008349 active site 755731008350 TDP-binding site; other site 755731008351 acceptor substrate-binding pocket; other site 755731008352 homodimer interface [polypeptide binding]; other site 755731008353 Phosphopantetheine attachment site; Region: PP-binding; pfam00550 755731008354 This family includes the Gtfs, a group of homologous glycosyltransferases involved in the final stages of the biosynthesis of antibiotics vancomycin and related chloroeremomycin. Gtfs transfer sugar moieties from an activated NDP-sugar donor to the...; Region: GT1_Gtf_like; cd03784 755731008355 glycosyltransferase, MGT family; Region: MGT; TIGR01426 755731008356 active site 755731008357 TDP-binding site; other site 755731008358 acceptor substrate-binding pocket; other site 755731008359 homodimer interface [polypeptide binding]; other site 755731008360 This family includes the Gtfs, a group of homologous glycosyltransferases involved in the final stages of the biosynthesis of antibiotics vancomycin and related chloroeremomycin. Gtfs transfer sugar moieties from an activated NDP-sugar donor to the...; Region: GT1_Gtf_like; cd03784 755731008361 glycosyltransferase, MGT family; Region: MGT; TIGR01426 755731008362 active site 755731008363 TDP-binding site; other site 755731008364 acceptor substrate-binding pocket; other site 755731008365 homodimer interface [polypeptide binding]; other site 755731008366 The adenylation domain of nonribosomal peptide synthetases (NRPS); Region: A_NRPS; cd05930 755731008367 amino acid adenylation domain; Region: AA-adenyl-dom; TIGR01733 755731008368 acyl-activating enzyme (AAE) consensus motif; other site 755731008369 AMP binding site [chemical binding]; other site 755731008370 Phosphopantetheine attachment site; Region: PP-binding; pfam00550 755731008371 (acyl-carrier-protein) S-malonyltransferase [Lipid metabolism]; Region: FabD; COG0331 755731008372 malonyl CoA-acyl carrier protein transacylase; Region: fabD; TIGR00128 755731008373 Condensation domain; Region: Condensation; pfam00668 755731008374 Non-ribosomal peptide synthetase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: EntF; COG1020 755731008375 HxxPF-repeated domain; Region: HxxPF_rpt; pfam13745 755731008376 Predicted enzyme involved in methoxymalonyl-ACP biosynthesis [Secondary metabolites biosynthesis, transport, and catabolism]; Region: FkbH; COG3882 755731008377 Acid Phosphatase; Region: Acid_PPase; cl17256 755731008378 Phosphopantetheine attachment site; Region: PP-binding; pfam00550 755731008379 Condensation domain; Region: Condensation; pfam00668 755731008380 Non-ribosomal peptide synthetase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: EntF; COG1020 755731008381 HxxPF-repeated domain; Region: HxxPF_rpt; pfam13745 755731008382 The adenylation domain of nonribosomal peptide synthetases (NRPS); Region: A_NRPS; cd05930 755731008383 acyl-activating enzyme (AAE) consensus motif; other site 755731008384 AMP binding site [chemical binding]; other site 755731008385 Phosphopantetheine attachment site; Region: PP-binding; pfam00550 755731008386 Condensation domain; Region: Condensation; pfam00668 755731008387 non-ribosomal peptide synthase domain TIGR01720; Region: NRPS-para261 755731008388 Beta-ketoacyl synthase; Region: PKS_KS; smart00825 755731008389 polyketide synthases (PKSs) polymerize simple fatty acids into a large variety of different products, called polyketides, by successive decarboxylating Claisen condensations. PKSs can be divided into 2 groups, modular type I PKSs consisting of one or...; Region: PKS; cd00833 755731008390 active site 755731008391 Acyl transferase domain; Region: Acyl_transf_1; cl08282 755731008392 Acyl transferase domain; Region: Acyl_transf_1; cl08282 755731008393 Phosphopantetheine attachment site; Region: PP-binding; pfam00550 755731008394 Acyl-CoA synthetases (AMP-forming)/AMP-acid ligases II [Lipid metabolism / Secondary metabolites biosynthesis, transport, and catabolism]; Region: CaiC; COG0318 755731008395 The adenylation domain of nonribosomal peptide synthetases (NRPS) similar to mycosubtilin synthase subunit A (MycA); Region: A_NRPS_MycA_like; cd05908 755731008396 acyl-activating enzyme (AAE) consensus motif; other site 755731008397 putative AMP binding site [chemical binding]; other site 755731008398 Phosphopantetheine attachment site; Region: PP-binding; pfam00550 755731008399 Condensation domain; Region: Condensation; pfam00668 755731008400 Non-ribosomal peptide synthetase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: EntF; COG1020 755731008401 HxxPF-repeated domain; Region: HxxPF_rpt; pfam13745 755731008402 The adenylation domain of nonribosomal peptide synthetases (NRPS), including salinosporamide A polyketide synthase; Region: A_NRPS_Ta1_like; cd12116 755731008403 acyl-activating enzyme (AAE) consensus motif; other site 755731008404 AMP binding site [chemical binding]; other site 755731008405 Phosphopantetheine attachment site; Region: PP-binding; pfam00550 755731008406 polyketide synthases (PKSs) polymerize simple fatty acids into a large variety of different products, called polyketides, by successive decarboxylating Claisen condensations. PKSs can be divided into 2 groups, modular type I PKSs consisting of one or...; Region: PKS; cd00833 755731008407 Beta-ketoacyl synthase; Region: PKS_KS; smart00825 755731008408 active site 755731008409 ketoreductase (KR), subgroup 2, complex (x) SDRs; Region: KR_2_SDR_x; cd08953 755731008410 putative NADP binding site [chemical binding]; other site 755731008411 This enzymatic domain is part of bacterial polyketide synthases; Region: PKS_KR; smart00822 755731008412 active site 755731008413 Dehydratase domain in polyketide synthase (PKS) enzymes; Region: PKS_DH; smart00826 755731008414 Phosphopantetheine attachment site; Region: PP-binding; pfam00550 755731008415 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 755731008416 ABC-type cobalt transport system, ATPase component [Inorganic ion transport and metabolism]; Region: CbiO; COG1122 755731008417 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 755731008418 Walker A/P-loop; other site 755731008419 ATP binding site [chemical binding]; other site 755731008420 ABC transporter signature motif; other site 755731008421 Walker B; other site 755731008422 D-loop; other site 755731008423 H-loop/switch region; other site 755731008424 Copper amine oxidase N-terminal domain; Region: Cu_amine_oxidN1; pfam07833 755731008425 Copper amine oxidase N-terminal domain; Region: Cu_amine_oxidN1; pfam07833 755731008426 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cl02429 755731008427 TPR motif; other site 755731008428 binding surface 755731008429 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 755731008430 TPR motif; other site 755731008431 binding surface 755731008432 Endoglucanase [Carbohydrate transport and metabolism]; Region: BglC; COG2730 755731008433 Cellulase (glycosyl hydrolase family 5); Region: Cellulase; pfam00150 755731008434 TIR domain; Region: TIR_2; pfam13676 755731008435 Protein of unknown function (DUF4231); Region: DUF4231; pfam14015 755731008436 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 755731008437 Walker A/P-loop; other site 755731008438 ATP binding site [chemical binding]; other site 755731008439 Q-loop/lid; other site 755731008440 Excinuclease ATPase subunit [DNA replication, recombination, and repair]; Region: UvrA; COG0178 755731008441 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 755731008442 ABC transporter signature motif; other site 755731008443 Walker B; other site 755731008444 D-loop; other site 755731008445 H-loop/switch region; other site 755731008446 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 755731008447 Walker A/P-loop; other site 755731008448 ATP binding site [chemical binding]; other site 755731008449 Q-loop/lid; other site 755731008450 ABC transporter signature motif; other site 755731008451 Walker B; other site 755731008452 D-loop; other site 755731008453 H-loop/switch region; other site 755731008454 Beta-lactamase class C and other penicillin binding proteins [Defense mechanisms]; Region: AmpC; COG1680 755731008455 Beta-lactamase; Region: Beta-lactamase; pfam00144 755731008456 FMN-dependent dehydrogenase; Region: FMN_dh; pfam01070 755731008457 Family of homologous FMN-dependent alpha-hydroxyacid oxidizing enzymes. This family occurs in both prokaryotes and eukaryotes. Members of this family include flavocytochrome b2 (FCB2), glycolate oxidase (GOX), lactate monooxygenase (LMO), mandelate...; Region: alpha_hydroxyacid_oxid_FMN; cd02809 755731008458 active site 755731008459 FMN binding site [chemical binding]; other site 755731008460 putative catalytic residues [active] 755731008461 ABC-2 family transporter protein; Region: ABC2_membrane_6; cl01496 755731008462 ABC-type uncharacterized transport system, permease component [General function prediction only]; Region: COG4587 755731008463 ABC-type uncharacterized transport system, permease component [General function prediction only]; Region: COG4587 755731008464 ABC-2 family transporter protein; Region: ABC2_membrane_6; cl01496 755731008465 ABC-type uncharacterized transport system, ATPase component [General function prediction only]; Region: COG4586 755731008466 ATP-binding cassette domain of an uncharacterized transporter similar in sequence to NatA; Region: ABC_NatA_like; cd03267 755731008467 Walker A/P-loop; other site 755731008468 ATP binding site [chemical binding]; other site 755731008469 Q-loop/lid; other site 755731008470 ABC transporter signature motif; other site 755731008471 Walker B; other site 755731008472 D-loop; other site 755731008473 H-loop/switch region; other site 755731008474 B12 binding domain_like associated with radical SAM domain. This domain shows similarity with B12 (adenosylcobamide) binding domains found in several enzymes, such as glutamate mutase, methionine synthase and methylmalonyl-CoA mutase, but it lacks the...; Region: radical_SAM_B12_BD; cd02068 755731008475 Elongator protein 3, MiaB family, Radical SAM; Region: Elp3; smart00729 755731008476 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 755731008477 FeS/SAM binding site; other site 755731008478 Predicted Fe-S oxidoreductases [General function prediction only]; Region: COG0535 755731008479 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 755731008480 FeS/SAM binding site; other site 755731008481 radical SAM additional 4Fe4S-binding SPASM domain; Region: rSAM_more_4Fe4S; TIGR04085 755731008482 Nudix hydrolase is a superfamily of enzymes found in all three kingdoms of life, and it catalyzes the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+...; Region: Nudix_Hydrolase; cl00447 755731008483 nudix motif; other site 755731008484 spiro-SPASM protein; Region: spiroSPASM; TIGR04321 755731008485 Domain of unknown function (DUF4008); Region: DUF4008; pfam13186 755731008486 Cellobiose phosphorylase [Carbohydrate transport and metabolism]; Region: COG3459 755731008487 N-terminal domain of chitobiose phosphorylase (ChBP) and similar proteins; Region: GH94N_ChBP_like; cd11755 755731008488 catalytic domain interface [polypeptide binding]; other site 755731008489 putative homodimer interface [polypeptide binding]; other site 755731008490 MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704 755731008491 FtsX-like permease family; Region: FtsX; pfam02687 755731008492 MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704 755731008493 ABC-type antimicrobial peptide transport system, permease component [Defense mechanisms]; Region: SalY; COG0577 755731008494 FtsX-like permease family; Region: FtsX; pfam02687 755731008495 ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136 755731008496 ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255 755731008497 Walker A/P-loop; other site 755731008498 ATP binding site [chemical binding]; other site 755731008499 Q-loop/lid; other site 755731008500 ABC transporter signature motif; other site 755731008501 Walker B; other site 755731008502 D-loop; other site 755731008503 H-loop/switch region; other site 755731008504 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 755731008505 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 755731008506 Transcriptional regulator C-terminal region; Region: TetR_C_8; pfam14278 755731008507 4-hydroxy-2-oxovalerate aldolase-like, N-terminal catalytic TIM barrel domain; Region: DRE_TIM_HOA_like; cd07944 755731008508 active site 755731008509 catalytic residues [active] 755731008510 metal binding site [ion binding]; metal-binding site 755731008511 ABC-2 family transporter protein; Region: ABC2_membrane_3; pfam12698 755731008512 ABC-type multidrug transport system, ATPase component [Defense mechanisms]; Region: CcmA; COG1131 755731008513 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 755731008514 Walker A/P-loop; other site 755731008515 ATP binding site [chemical binding]; other site 755731008516 Q-loop/lid; other site 755731008517 ABC transporter signature motif; other site 755731008518 Walker B; other site 755731008519 D-loop; other site 755731008520 H-loop/switch region; other site 755731008521 short chain dehydrogenase; Provisional; Region: PRK06701 755731008522 classical (c) SDR, subgroup 1; Region: SDR_c1; cd05355 755731008523 NAD binding site [chemical binding]; other site 755731008524 metal binding site [ion binding]; metal-binding site 755731008525 active site 755731008526 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 755731008527 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 755731008528 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3708 755731008529 Methyltransferase domain; Region: Methyltransf_31; pfam13847 755731008530 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 755731008531 S-adenosylmethionine binding site [chemical binding]; other site 755731008532 Acetyltransferase (isoleucine patch superfamily) [General function prediction only]; Region: WbbJ; COG0110 755731008533 Xenobiotic acyltransferase (XAT): The XAT class of hexapeptide acyltransferases is composed of a large number of microbial enzymes that catalyze the CoA-dependent acetylation of a variety of hydroxyl-bearing acceptors such as chloramphenicol and...; Region: LbH_XAT; cd03349 755731008534 trimer interface [polypeptide binding]; other site 755731008535 active site 755731008536 substrate binding site [chemical binding]; other site 755731008537 CoA binding site [chemical binding]; other site 755731008538 Predicted nucleotidyltransferase [General function prediction only]; Region: COG3541 755731008539 Predicted nucleotidyltransferase; Region: Nuc-transf; cl01417 755731008540 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 755731008541 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 755731008542 GyrI-like small molecule binding domain; Region: GyrI-like; cl01368 755731008543 alpha-glucosidase; Provisional; Region: PRK10426 755731008544 YihQ is a bacterial alpha-glucosidase with a conserved glycosyl hydrolase family 31 (GH31) domain that catalyzes the release of an alpha-glucosyl residue from the non-reducing end of alpha-glucoside substrates such as alpha-glucosyl fluoride. Orthologs...; Region: GH31_glucosidase_YihQ; cd06594 755731008545 putative active site [active] 755731008546 putative catalytic site [active] 755731008547 ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395 755731008548 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 755731008549 dimer interface [polypeptide binding]; other site 755731008550 conserved gate region; other site 755731008551 putative PBP binding loops; other site 755731008552 ABC-ATPase subunit interface; other site 755731008553 ABC-type polysaccharide transport system, permease component [Carbohydrate transport and metabolism]; Region: LplB; COG4209 755731008554 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 755731008555 dimer interface [polypeptide binding]; other site 755731008556 conserved gate region; other site 755731008557 putative PBP binding loops; other site 755731008558 ABC-ATPase subunit interface; other site 755731008559 ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653 755731008560 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; pfam01547 755731008561 MarR family; Region: MarR; pfam01047 755731008562 Transcriptional regulator/sugar kinase [Transcription / Carbohydrate transport and metabolism]; Region: NagC; COG1940 755731008563 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cl17037 755731008564 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cl17037 755731008565 Permeases of the drug/metabolite transporter (DMT) superfamily [Carbohydrate transport and metabolism / Amino acid transport and metabolism / General function prediction only]; Region: RhaT; COG0697 755731008566 EamA-like transporter family; Region: EamA; pfam00892 755731008567 Transaldolase; Region: Transaldolase; pfam00923 755731008568 catalytic residue [active] 755731008569 L-fucose isomerase (FucIase) and L-arabinose isomerase (AI) family; composed of FucIase, AI and similar proteins. FucIase converts L-fucose, an aldohexose, to its ketose form, which prepares it for aldol cleavage (similar to the isomerization of glucose...; Region: L-fuc_L-ara-isomerases; cl00947 755731008570 hexamer (dimer of trimers) interface [polypeptide binding]; other site 755731008571 trimer interface [polypeptide binding]; other site 755731008572 substrate binding site [chemical binding]; other site 755731008573 Mn binding site [ion binding]; other site 755731008574 Class I aldolases; Region: Aldolase_Class_I; cl17187 755731008575 catalytic residue [active] 755731008576 Ribose/Galactose Isomerase; Region: LacAB_rpiB; pfam02502 755731008577 Transketolase, C-terminal subunit [Carbohydrate transport and metabolism]; Region: COG3958 755731008578 Pyrimidine (PYR) binding domain of 1-deoxy-D-xylulose-5-phosphate synthase (DXS), transketolase (TK), and related proteins; Region: TPP_PYR_DXS_TK_like; cd07033 755731008579 PYR/PP interface [polypeptide binding]; other site 755731008580 dimer interface [polypeptide binding]; other site 755731008581 TPP binding site [chemical binding]; other site 755731008582 Transketolase, C-terminal domain; Region: Transketolase_C; pfam02780 755731008583 transketolase; Reviewed; Region: PRK05899 755731008584 Thiamine pyrophosphate (TPP) family, Transketolase (TK) subfamily, TPP-binding module; TK catalyzes the transfer of a two-carbon unit from ketose phosphates to aldose phosphates. In heterotrophic organisms, TK provides a link between glycolysis and the...; Region: TPP_TK; cd02012 755731008585 TPP-binding site [chemical binding]; other site 755731008586 dimer interface [polypeptide binding]; other site 755731008587 Alcohol dehydrogenase, class IV [Energy production and conversion]; Region: EutG; COG1454 755731008588 iron-containing alcohol dehydrogenases (Fe-ADH)-like; Region: Fe-ADH; cd08551 755731008589 active site 755731008590 metal binding site [ion binding]; metal-binding site 755731008591 Glycerol dehydrogenase and related enzymes [Energy production and conversion]; Region: GldA; COG0371 755731008592 Glycerol dehydrogenases (GlyDH) catalyzes oxidation of glycerol to dihydroxyacetone in glycerol dissmilation; Region: GlyDH; cd08170 755731008593 dimer interface [polypeptide binding]; other site 755731008594 active site 755731008595 metal binding site [ion binding]; metal-binding site 755731008596 Sensory domain found in PocR; Region: PocR; pfam10114 755731008597 Predicted sensor domain [Signal transduction mechanisms / Transcription]; Region: PocR; COG4936 755731008598 AraC-type DNA-binding domain-containing proteins [Transcription]; Region: AraC; COG2207 755731008599 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 755731008600 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 755731008601 Protein chain release factor B [Translation, ribosomal structure and biogenesis]; Region: PrfB; COG1186 755731008602 RF-1 domain; Region: RF-1; cl17422 755731008603 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 755731008604 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 755731008605 S-layer homology domain; Region: SLH; pfam00395 755731008606 S-layer homology domain; Region: SLH; pfam00395 755731008607 Bacterial surface proteins containing Ig-like domains [Cell motility and secretion]; Region: COG5492 755731008608 Bacterial Ig-like domain (group 2); Region: Big_2; pfam02368 755731008609 Dockerin type I repeat; Region: Dockerin_1; pfam00404 755731008610 Dockerin type I repeat; Region: Dockerin_1; pfam00404 755731008611 ABC-type phosphate transport system, periplasmic component [Inorganic ion transport and metabolism]; Region: PstS; COG0226 755731008612 glucosamine--fructose-6-phosphate aminotransferase; Reviewed; Region: PRK00331 755731008613 Glutamine amidotransferases class-II (Gn-AT)_GFAT-type. This domain is found at the N-terminus of glucosamine-6P synthase (GlmS, or GFAT in humans). The glutaminase domain catalyzes amide nitrogen transfer from glutamine to the appropriate substrate. In...; Region: GFAT; cd00714 755731008614 glutaminase active site [active] 755731008615 SIS (Sugar ISomerase) domain repeat 1 found in Glucosamine 6-phosphate synthase (GlmS) and Glucosamine-6-phosphate deaminase (GlmD). The SIS domain is found in many phosphosugar isomerases and phosphosugar binding proteins. GlmS contains a N-terminal...; Region: SIS_GlmS_GlmD_1; cd05008 755731008616 dimer interface [polypeptide binding]; other site 755731008617 active site 755731008618 SIS (Sugar ISomerase) domain repeat 2 found in Glucosamine 6-phosphate synthase (GlmS) and Glucosamine-6-phosphate deaminase (GlmD). The SIS domain is found in many phosphosugar isomerases and phosphosugar binding proteins. GlmS contains a N-terminal...; Region: SIS_GlmS_GlmD_2; cd05009 755731008619 dimer interface [polypeptide binding]; other site 755731008620 active site 755731008621 phosphoglucosamine mutase; Provisional; Region: glmM; PRK14316 755731008622 GlmM is a bacterial phosphoglucosamine mutase (PNGM) that belongs to the alpha-D-phosphohexomutase superfamily. It is required for the interconversion of glucosamine-6-phosphate and glucosamine-1-phosphate in the biosynthetic pathway of...; Region: GlmM; cd05802 755731008623 active site 755731008624 substrate binding site [chemical binding]; other site 755731008625 metal binding site [ion binding]; metal-binding site 755731008626 Uncharacterized FAD-dependent dehydrogenases [General function prediction only]; Region: COG2509 755731008627 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450 755731008628 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4856 755731008629 YbbR-like protein; Region: YbbR; pfam07949 755731008630 Uncharacterized conserved protein [Function unknown]; Region: COG1624 755731008631 DisA bacterial checkpoint controller nucleotide-binding; Region: DisA_N; pfam02457 755731008632 NAD synthetase; Reviewed; Region: nadE; PRK02628 755731008633 Glutamine aminotransferase (GAT, glutaminase) domain of glutamine-dependent NAD synthetases (class 7 and 8 nitrilases); Region: GAT_Gln-NAD-synth; cd07570 755731008634 multimer interface [polypeptide binding]; other site 755731008635 active site 755731008636 catalytic triad [active] 755731008637 protein interface 1 [polypeptide binding]; other site 755731008638 NAD+ synthase is a homodimer, which catalyzes the final step in de novo nicotinamide adenine dinucleotide (NAD+) biosynthesis, an amide transfer from either ammonia or glutamine to nicotinic acid adenine dinucleotide (NaAD). The conversion of NaAD to NAD...; Region: NAD_synthase; cd00553 755731008639 homodimer interface [polypeptide binding]; other site 755731008640 NAD binding pocket [chemical binding]; other site 755731008641 ATP binding pocket [chemical binding]; other site 755731008642 Mg binding site [ion binding]; other site 755731008643 active-site loop [active] 755731008644 Selenocysteine lyase/Cysteine desulfurase [Posttranslational modification, protein turnover, chaperones]; Region: csdA; COG0520 755731008645 Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321 755731008646 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 755731008647 catalytic residue [active] 755731008648 valyl-tRNA synthetase; Reviewed; Region: valS; PRK05729 755731008649 nucleotidyl transferase superfamily; Region: nt_trans; cl00015 755731008650 active site 755731008651 HIGH motif; other site 755731008652 nucleotide binding site [chemical binding]; other site 755731008653 Leucyl-tRNA synthetase, Domain 2; Region: tRNA-synt_1_2; pfam13603 755731008654 catalytic core domain of valyl-tRNA synthetases; Region: ValRS_core; cd00817 755731008655 active site 755731008656 KMSKS motif; other site 755731008657 Anticodon-binding domain of valyl tRNA synthetases; Region: Anticodon_Ia_Val; cd07962 755731008658 tRNA binding surface [nucleotide binding]; other site 755731008659 anticodon binding site; other site 755731008660 Valyl tRNA synthetase tRNA binding arm; Region: Val_tRNA-synt_C; pfam10458 755731008661 Predicted permease, member of the PurR regulon [General function prediction only]; Region: yhhT; COG0628 755731008662 Domain of unknown function DUF20; Region: UPF0118; pfam01594 755731008663 YtxH-like protein; Region: YtxH; cl02079 755731008664 PRC-barrel domain; Region: PRC; pfam05239 755731008665 PRC-barrel domain; Region: PRC; pfam05239 755731008666 Protein of unknown function (DUF1015); Region: DUF1015; pfam06245 755731008667 Uncharacterized conserved protein [Function unknown]; Region: COG4198 755731008668 ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132 755731008669 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 755731008670 ATP-binding cassette domain of glucan transporter and related proteins, subfamily C; Region: ABCC_Glucan_exporter_like; cd03254 755731008671 Walker A/P-loop; other site 755731008672 ATP binding site [chemical binding]; other site 755731008673 Q-loop/lid; other site 755731008674 ABC transporter signature motif; other site 755731008675 Walker B; other site 755731008676 D-loop; other site 755731008677 H-loop/switch region; other site 755731008678 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 755731008679 ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132 755731008680 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 755731008681 Walker A/P-loop; other site 755731008682 ATP binding site [chemical binding]; other site 755731008683 Q-loop/lid; other site 755731008684 ABC transporter signature motif; other site 755731008685 Walker B; other site 755731008686 D-loop; other site 755731008687 H-loop/switch region; other site 755731008688 helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347 755731008689 MarR family; Region: MarR; pfam01047 755731008690 D-3-phosphoglycerate dehydrogenase; Provisional; Region: PRK13581 755731008691 Phosphoglycerate dehydrogenases, NAD-binding and catalytic domains; Region: PGDH_4; cd12173 755731008692 ligand binding site [chemical binding]; other site 755731008693 NAD binding site [chemical binding]; other site 755731008694 dimerization interface [polypeptide binding]; other site 755731008695 catalytic site [active] 755731008696 C-terminal ACT (regulatory) domain of D-3-phosphoglycerate dehydrogenase (3PGDH); Region: ACT_3PGDH-xct; cd04902 755731008697 putative L-serine binding site [chemical binding]; other site 755731008698 Glycosyl hydrolases family 11; Region: Glyco_hydro_11; pfam00457 755731008699 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 755731008700 TPR motif; other site 755731008701 TPR repeat; Region: TPR_11; pfam13414 755731008702 binding surface 755731008703 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 755731008704 binding surface 755731008705 TPR motif; other site 755731008706 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 755731008707 binding surface 755731008708 TPR repeat; Region: TPR_11; pfam13414 755731008709 TPR motif; other site 755731008710 TPR repeat; Region: TPR_11; pfam13414 755731008711 Tetratricopeptide repeat; Region: TPR_9; pfam13371 755731008712 Predicted RNA-binding protein; Region: RNA_bind_2; pfam10133 755731008713 Domain of unknown function (DUF3842); Region: DUF3842; pfam12953 755731008714 ABC-type cobalt transport system, ATPase component [Inorganic ion transport and metabolism]; Region: CbiO; COG1122 755731008715 First domain of the ATP-binding cassette component of cobalt transport system; Region: ABC_cobalt_CbiO_domain1; cd03225 755731008716 Walker A/P-loop; other site 755731008717 ATP binding site [chemical binding]; other site 755731008718 Q-loop/lid; other site 755731008719 ABC transporter signature motif; other site 755731008720 Walker B; other site 755731008721 D-loop; other site 755731008722 H-loop/switch region; other site 755731008723 cobalt ABC transporter, permease protein CbiQ; Region: CbiQ_TIGR; TIGR02454 755731008724 ABC-type Co2+ transport system, permease component [Inorganic ion transport and metabolism]; Region: CbiM; cl00397 755731008725 Cobalt uptake substrate-specific transmembrane region; Region: CbiM; pfam01891 755731008726 PDGLE domain; Region: PDGLE; pfam13190 755731008727 ABC-type Mn/Zn transport systems, ATPase component [Inorganic ion transport and metabolism]; Region: ZnuC; COG1121 755731008728 ATP-binding cassette domain of the drug resistance transporter and related proteins, subfamily A; Region: ABC_DR_subfamily_A; cd03230 755731008729 Walker A/P-loop; other site 755731008730 ATP binding site [chemical binding]; other site 755731008731 Q-loop/lid; other site 755731008732 ABC transporter signature motif; other site 755731008733 Walker B; other site 755731008734 D-loop; other site 755731008735 H-loop/switch region; other site 755731008736 Phosphomannose isomerase [Carbohydrate transport and metabolism]; Region: ManA; COG1482 755731008737 Alpha-Mannosidase Binding Domain of Atg19/34; Region: ABD; cl15429 755731008738 ABC-type Na+ efflux pump, permease component [Energy production and conversion / Inorganic ion transport and metabolism]; Region: NatB; COG1668 755731008739 ABC-type uncharacterized transport system, ATPase component [General function prediction only]; Region: COG4152 755731008740 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 755731008741 Walker A/P-loop; other site 755731008742 ATP binding site [chemical binding]; other site 755731008743 Q-loop/lid; other site 755731008744 ABC transporter signature motif; other site 755731008745 Walker B; other site 755731008746 D-loop; other site 755731008747 H-loop/switch region; other site 755731008748 Domain of unknown function (DUF4162); Region: DUF4162; pfam13732 755731008749 Protein of unknown function (DUF2812); Region: DUF2812; pfam11193 755731008750 Predicted transcriptional regulators [Transcription]; Region: COG1695 755731008751 Transcriptional regulator PadR-like family; Region: PadR; pfam03551 755731008752 HTH-like domain; Region: HTH_21; pfam13276 755731008753 Integrase core domain; Region: rve; pfam00665 755731008754 Integrase core domain; Region: rve_2; pfam13333 755731008755 Escherichia coli UshA-like family, N-terminal metallophosphatase domain; Region: MPP_UshA_N_like; cd00845 755731008756 Calcineurin-like phosphoesterase; Region: Metallophos; pfam00149 755731008757 active site 755731008758 metal binding site [ion binding]; metal-binding site 755731008759 5'-nucleotidase, C-terminal domain; Region: 5_nucleotid_C; pfam02872 755731008760 3-ketoacyl-(acyl-carrier-protein) reductase; Provisional; Region: fabG; PRK05565 755731008761 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 755731008762 NAD(P) binding site [chemical binding]; other site 755731008763 active site 755731008764 Cupin domain; Region: Cupin_2; cl17218 755731008765 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 755731008766 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 755731008767 Permeases of the drug/metabolite transporter (DMT) superfamily [Carbohydrate transport and metabolism / Amino acid transport and metabolism / General function prediction only]; Region: RhaT; COG0697 755731008768 EamA-like transporter family; Region: EamA; cl17759 755731008769 Lyase, catalytic; Region: Lyase_catalyt; pfam09093 755731008770 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 755731008771 dimerization interface [polypeptide binding]; other site 755731008772 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 755731008773 dimer interface [polypeptide binding]; other site 755731008774 phosphorylation site [posttranslational modification] 755731008775 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 755731008776 ATP binding site [chemical binding]; other site 755731008777 Mg2+ binding site [ion binding]; other site 755731008778 G-X-G motif; other site 755731008779 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 755731008780 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 755731008781 active site 755731008782 phosphorylation site [posttranslational modification] 755731008783 intermolecular recognition site; other site 755731008784 dimerization interface [polypeptide binding]; other site 755731008785 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 755731008786 DNA binding site [nucleotide binding] 755731008787 SNARE associated Golgi protein; Region: SNARE_assoc; cl00429 755731008788 Uncharacterized membrane-associated protein [Function unknown]; Region: DedA; COG0586 755731008789 Uncharacterized conserved protein [Function unknown]; Region: COG1633 755731008790 Ferritin-like superfamily of diiron-containing four-helix-bundle proteins; Region: Ferritin_like; cd00657 755731008791 dinuclear metal binding motif [ion binding]; other site 755731008792 Response regulator of the LytR/AlgR family [Transcription / Signal transduction mechanisms]; Region: LytT; COG3279 755731008793 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 755731008794 active site 755731008795 phosphorylation site [posttranslational modification] 755731008796 intermolecular recognition site; other site 755731008797 dimerization interface [polypeptide binding]; other site 755731008798 LytTr DNA-binding domain; Region: LytTR; smart00850 755731008799 Domain of unknown function (DUF3787); Region: DUF3787; pfam12655 755731008800 pyruvate:ferredoxin (flavodoxin) oxidoreductase, homodimeric; Region: pyruv_ox_red; TIGR02176 755731008801 Pyrimidine (PYR) binding domain of pyruvate ferredoxin oxidoreductase (PFOR), indolepyruvate ferredoxin oxidoreductase alpha subunit (IOR-alpha), and related proteins; Region: TPP_PYR_PFOR_IOR-alpha_like; cd07034 755731008802 dimer interface [polypeptide binding]; other site 755731008803 PYR/PP interface [polypeptide binding]; other site 755731008804 TPP binding site [chemical binding]; other site 755731008805 substrate binding site [chemical binding]; other site 755731008806 Pyruvate:ferredoxin oxidoreductase and related 2-oxoacid:ferredoxin oxidoreductases, gamma subunit [Energy production and conversion]; Region: PorG; COG1014 755731008807 Domain of unknown function; Region: EKR; pfam10371 755731008808 The HCP family of iron-sulfur proteins includes hybrid cluster protein (HCP), acetyl-CoA synthase (ACS), and carbon monoxide dehydrogenase (CODH), all of which contain [Fe4-S4] metal clusters at their active sites. These proteins have a conserved...; Region: HCP_like; cl14655 755731008809 Thiamine pyrophosphate (TPP family), PFOR_PNO subfamily, TPP-binding module; composed of proteins similar to the single subunit pyruvate ferredoxin oxidoreductase (PFOR) of Desulfovibrio Africanus, present in bacteria and amitochondriate eukaryotes. This...; Region: TPP_PFOR_PNO; cd03377 755731008810 TPP-binding site [chemical binding]; other site 755731008811 dimer interface [polypeptide binding]; other site 755731008812 ABC-type multidrug transport system, ATPase component [Defense mechanisms]; Region: CcmA; COG1131 755731008813 ATP-binding cassette domain of the bacitracin-resistance transporter; Region: ABC_BcrA_bacitracin_resist; cd03268 755731008814 Walker A/P-loop; other site 755731008815 ATP binding site [chemical binding]; other site 755731008816 Q-loop/lid; other site 755731008817 ABC transporter signature motif; other site 755731008818 Walker B; other site 755731008819 D-loop; other site 755731008820 H-loop/switch region; other site 755731008821 ABC-2 family transporter protein; Region: ABC2_membrane_2; cl17866 755731008822 ABC-2 family transporter protein; Region: ABC2_membrane_4; pfam12730 755731008823 ABC-2 family transporter protein; Region: ABC2_membrane_4; pfam12730 755731008824 ABC-2 family transporter protein; Region: ABC2_membrane_2; cl17866 755731008825 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 755731008826 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 755731008827 dimer interface [polypeptide binding]; other site 755731008828 phosphorylation site [posttranslational modification] 755731008829 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 755731008830 ATP binding site [chemical binding]; other site 755731008831 Mg2+ binding site [ion binding]; other site 755731008832 G-X-G motif; other site 755731008833 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 755731008834 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 755731008835 active site 755731008836 phosphorylation site [posttranslational modification] 755731008837 intermolecular recognition site; other site 755731008838 dimerization interface [polypeptide binding]; other site 755731008839 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 755731008840 DNA binding site [nucleotide binding] 755731008841 Helical backbone metal receptor (TroA-like domain). These proteins have been shown to function in the ABC transport of ferric siderophores and metal ions such as Mn2+, Fe3+, Cu2+ and/or Zn2+. Their ligand binding site is formed in the interface between...; Region: TroA-like; cl00262 755731008842 Periplasmic solute binding protein family; Region: SBP_bac_9; pfam01297 755731008843 intersubunit interface [polypeptide binding]; other site 755731008844 Sugar kinases, ribokinase family [Carbohydrate transport and metabolism]; Region: RbsK; COG0524 755731008845 ribokinase/pfkB superfamily: Kinases that accept a wide variety of substrates, including carbohydrates and aromatic small molecules, all are phosphorylated at a hydroxyl group. The superfamily includes ribokinase, fructokinase, ketohexokinase; Region: ribokinase_pfkB_like; cl00192 755731008846 substrate binding site [chemical binding]; other site 755731008847 ATP binding site [chemical binding]; other site 755731008848 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 755731008849 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cl01054 755731008850 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 755731008851 dimer interface [polypeptide binding]; other site 755731008852 phosphorylation site [posttranslational modification] 755731008853 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 755731008854 ATP binding site [chemical binding]; other site 755731008855 Mg2+ binding site [ion binding]; other site 755731008856 G-X-G motif; other site 755731008857 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 755731008858 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 755731008859 active site 755731008860 phosphorylation site [posttranslational modification] 755731008861 intermolecular recognition site; other site 755731008862 dimerization interface [polypeptide binding]; other site 755731008863 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 755731008864 DNA binding site [nucleotide binding] 755731008865 MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704 755731008866 ABC-type antimicrobial peptide transport system, permease component [Defense mechanisms]; Region: SalY; COG0577 755731008867 FtsX-like permease family; Region: FtsX; pfam02687 755731008868 ABC-type transport system, involved in lipoprotein release, permease component [Cell envelope biogenesis, outer membrane]; Region: LolE; COG4591 755731008869 FtsX-like permease family; Region: FtsX; pfam02687 755731008870 ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136 755731008871 ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255 755731008872 Walker A/P-loop; other site 755731008873 ATP binding site [chemical binding]; other site 755731008874 Q-loop/lid; other site 755731008875 ABC transporter signature motif; other site 755731008876 Walker B; other site 755731008877 D-loop; other site 755731008878 H-loop/switch region; other site 755731008879 Glycosyl hydrolases family 8; Region: Glyco_hydro_8; cl01351 755731008880 Mg2+ and Co2+ transporters [Inorganic ion transport and metabolism]; Region: CorA; COG0598 755731008881 Thermotoga maritima CorA_like subfamily; Region: TmCorA-like_1; cd12828 755731008882 oligomer interface [polypeptide binding]; other site 755731008883 metal binding site [ion binding]; metal-binding site 755731008884 metal binding site [ion binding]; metal-binding site 755731008885 Cl binding site [ion binding]; other site 755731008886 aspartate ring; other site 755731008887 basic sphincter; other site 755731008888 putative hydrophobic gate; other site 755731008889 periplasmic entrance; other site 755731008890 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 755731008891 non-specific DNA binding site [nucleotide binding]; other site 755731008892 salt bridge; other site 755731008893 sequence-specific DNA binding site [nucleotide binding]; other site 755731008894 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 755731008895 S-adenosylmethionine binding site [chemical binding]; other site 755731008896 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 755731008897 S-adenosylmethionine binding site [chemical binding]; other site 755731008898 undecaprenyl pyrophosphate phosphatase; Reviewed; Region: PRK00281 755731008899 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG2963 755731008900 Helix-turn-helix domain; Region: HTH_28; pfam13518 755731008901 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG2963 755731008902 Transposase; Region: HTH_Tnp_1; cl17663 755731008903 Helix-turn-helix domain; Region: HTH_28; pfam13518 755731008904 HTH-like domain; Region: HTH_21; pfam13276 755731008905 Integrase core domain; Region: rve; pfam00665 755731008906 Integrase core domain; Region: rve_2; pfam13333 755731008907 Copper amine oxidase N-terminal domain; Region: Cu_amine_oxidN1; pfam07833 755731008908 CoA-disulfide reductase; Region: CoA_CoA_reduc; TIGR03385 755731008909 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 755731008910 Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain; Region: Pyr_redox_dim; pfam02852 755731008911 Member of the Rhodanese Homology Domain superfamily. Included in this CD are the Lactococcus lactis NADH oxidase, Bacillus cereus NADH dehydrogenase, and Bacteroides thetaiotaomicron pyridine nucleotide-disulphide oxidoreductase, and similar...; Region: RHOD_Pyr_redox; cd01524 755731008912 active site residue [active] 755731008913 SirA, YedF, and YeeD. Two-layered alpha/beta sandwich domain. SirA (also known as UvrY, and YhhP) belongs to a family of bacterial two-component response regulators that controls secondary metabolism and virulence. The other member of this...; Region: SirA_YedF_YeeD; cl00436 755731008914 CPxP motif; other site 755731008915 DsrE/DsrF/DrsH-like family; Region: DrsE_2; pfam13686 755731008916 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 755731008917 dimerization interface [polypeptide binding]; other site 755731008918 putative DNA binding site [nucleotide binding]; other site 755731008919 putative Zn2+ binding site [ion binding]; other site 755731008920 4'-phosphopantetheinyl transferase superfamily; Region: ACPS; pfam01648 755731008921 Glycosyl transferases, related to UDP-glucuronosyltransferase [Carbohydrate transport and metabolism / Signal transduction mechanisms]; Region: COG1819 755731008922 Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013 755731008923 4-hydroxybenzoyl-CoA thioesterase (4HBT). Catalyzes the final step in the 4-chlorobenzoate degradation pathway in which 4-chlorobenzoate is converted to 4-hydroxybenzoate in certain soil-dwelling bacteria. 4HBT forms a homotetramer with four active sites; Region: 4HBT; cd00586 755731008924 active site 755731008925 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394 755731008926 active site 755731008927 Multimeric flavodoxin WrbA [General function prediction only]; Region: WrbA; COG0655 755731008928 NADPH-dependent FMN reductase; Region: FMN_red; pfam03358 755731008929 3-oxoacyl-(acyl-carrier-protein) synthase [Lipid metabolism / Secondary metabolites biosynthesis, transport, and catabolism]; Region: FabB; COG0304 755731008930 Beta-ketoacyl-acyl carrier protein (ACP) synthase (KAS), type I and II. KASs are responsible for the elongation steps in fatty acid biosynthesis. KASIII catalyses the initial condensation and KAS I and II catalyze further elongation steps by Claisen...; Region: KAS_I_II; cd00834 755731008931 dimer interface [polypeptide binding]; other site 755731008932 active site 755731008933 beta-ketoacyl-acyl-carrier-protein synthase II; Region: fabF; TIGR03150 755731008934 Condensing enzymes; Family of enzymes that catalyze a (decarboxylating or non-decarboxylating) Claisen-like condensation reaction. Members are share strong structural similarity, and are involved in the synthesis and degradation of fatty acids, and the...; Region: cond_enzymes; cl09938 755731008935 active site 755731008936 Aminomethyltransferase folate-binding domain; Region: GCV_T; pfam01571 755731008937 Glycine cleavage T-protein C-terminal barrel domain; Region: GCV_T_C; pfam08669 755731008938 ABC-2 family transporter protein; Region: ABC2_membrane_3; pfam12698 755731008939 ABC-type multidrug transport system, ATPase component [Defense mechanisms]; Region: CcmA; COG1131 755731008940 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 755731008941 Walker A/P-loop; other site 755731008942 ATP binding site [chemical binding]; other site 755731008943 Q-loop/lid; other site 755731008944 ABC transporter signature motif; other site 755731008945 Walker B; other site 755731008946 D-loop; other site 755731008947 H-loop/switch region; other site 755731008948 FabZ is a 17kD beta-hydroxyacyl-acyl carrier protein (ACP) dehydratase that primarily catalyzes the dehydration of beta-hydroxyacyl-ACP to trans-2-acyl-ACP, the third step in the elongation phase of the bacterial/ plastid, type II, fatty-acid...; Region: FabZ; cd01288 755731008949 Phosphopantetheine attachment site; Region: PP-binding; cl09936 755731008950 3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05557 755731008951 beta-Keto acyl carrier protein reductase (BKR), involved in Type II FAS, classical (c) SDRs; Region: BKR_SDR_c; cd05333 755731008952 NAD(P) binding site [chemical binding]; other site 755731008953 homotetramer interface [polypeptide binding]; other site 755731008954 homodimer interface [polypeptide binding]; other site 755731008955 active site 755731008956 (acyl-carrier-protein) S-malonyltransferase [Lipid metabolism]; Region: FabD; COG0331 755731008957 malonyl CoA-acyl carrier protein transacylase; Region: fabD; TIGR00128 755731008958 4-hydroxybenzoyl-CoA thioesterase (4HBT). Catalyzes the final step in the 4-chlorobenzoate degradation pathway in which 4-chlorobenzoate is converted to 4-hydroxybenzoate in certain soil-dwelling bacteria. 4HBT forms a homotetramer with four active sites; Region: 4HBT; cd00586 755731008959 active site 755731008960 NADPH-dependent FMN reductase; Region: FMN_red; pfam03358 755731008961 Multimeric flavodoxin WrbA [General function prediction only]; Region: WrbA; COG0655 755731008962 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 755731008963 Radical SAM superfamily; Region: Radical_SAM; pfam04055 755731008964 FeS/SAM binding site; other site 755731008965 methylated-DNA--protein-cysteine methyltransferase; Provisional; Region: PRK00901 755731008966 The DNA repair protein O6-alkylguanine-DNA alkyltransferase (ATase; also known as AGT, AGAT and MGMT) reverses O6-alkylation DNA damage by transferring O6-alkyl adducts to an active site cysteine irreversibly, without inducing DNA strand breaks. ATases...; Region: ATase; cd06445 755731008967 DNA binding site [nucleotide binding] 755731008968 active site 755731008969 Beta-glucosidase-related glycosidases [Carbohydrate transport and metabolism]; Region: BglX; COG1472 755731008970 Glycosyl hydrolase family 3 N terminal domain; Region: Glyco_hydro_3; pfam00933 755731008971 Glycosyl hydrolase family 3 C-terminal domain; Region: Glyco_hydro_3_C; pfam01915 755731008972 Fibronectin type III-like domain; Region: Fn3-like; pfam14310 755731008973 Predicted oxidoreductases of the aldo/keto reductase family [General function prediction only]; Region: COG1453 755731008974 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 755731008975 active site 755731008976 catalytic tetrad [active] 755731008977 The HCP family of iron-sulfur proteins includes hybrid cluster protein (HCP), acetyl-CoA synthase (ACS), and carbon monoxide dehydrogenase (CODH), all of which contain [Fe4-S4] metal clusters at their active sites. These proteins have a conserved...; Region: HCP_like; cl14655 755731008978 Response regulator receiver domain; Region: Response_reg; pfam00072 755731008979 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 755731008980 active site 755731008981 phosphorylation site [posttranslational modification] 755731008982 intermolecular recognition site; other site 755731008983 dimerization interface [polypeptide binding]; other site 755731008984 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 755731008985 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 755731008986 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 755731008987 Predicted signal transduction protein with a C-terminal ATPase domain [Signal transduction mechanisms]; Region: COG2972 755731008988 HAMP (Histidine kinases, Adenylyl cyclases, Methyl binding proteins, Phosphatases) domain; Region: HAMP; smart00304 755731008989 dimerization interface [polypeptide binding]; other site 755731008990 Histidine kinase; Region: His_kinase; pfam06580 755731008991 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 755731008992 ATP binding site [chemical binding]; other site 755731008993 Mg2+ binding site [ion binding]; other site 755731008994 G-X-G motif; other site 755731008995 ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653 755731008996 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; pfam01547 755731008997 ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395 755731008998 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 755731008999 dimer interface [polypeptide binding]; other site 755731009000 conserved gate region; other site 755731009001 putative PBP binding loops; other site 755731009002 ABC-ATPase subunit interface; other site 755731009003 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 755731009004 dimer interface [polypeptide binding]; other site 755731009005 conserved gate region; other site 755731009006 putative PBP binding loops; other site 755731009007 ABC-ATPase subunit interface; other site 755731009008 ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653 755731009009 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; pfam01547 755731009010 Predicted membrane protein involved in D-alanine export [Cell envelope biogenesis, outer membrane]; Region: DltB; COG1696 755731009011 carboxynorspermidine decarboxylase; Region: nspC; TIGR01047 755731009012 Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzyme Carboxynorspermidine Decarboxylase; Region: PLPDE_III_CANSDC; cd06829 755731009013 dimer interface [polypeptide binding]; other site 755731009014 active site 755731009015 pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site 755731009016 catalytic residues [active] 755731009017 substrate binding site [chemical binding]; other site 755731009018 Saccharopine dehydrogenase and related proteins [Amino acid transport and metabolism]; Region: LYS9; COG1748 755731009019 NAD(P) binding domain of Shikimate dehydrogenase; Region: NAD_bind_Shikimate_DH; cd01065 755731009020 Copper amine oxidase N-terminal domain; Region: Cu_amine_oxidN1; pfam07833 755731009021 Copper amine oxidase N-terminal domain; Region: Cu_amine_oxidN1; pfam07833 755731009022 Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673 755731009023 Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408 755731009024 Oxidoreductase family, C-terminal alpha/beta domain; Region: GFO_IDH_MocA_C; pfam02894 755731009025 Predicted membrane protein [Function unknown]; Region: COG2323 755731009026 Domain of unknown function (DUF4363); Region: DUF4363; pfam14276 755731009027 Predicted membrane protein [Function unknown]; Region: COG2323 755731009028 Domain of unknown function (DUF4363); Region: DUF4363; pfam14276 755731009029 arginine decarboxylase; Provisional; Region: PRK05354 755731009030 Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzyme Arginine Decarboxylase; Region: PLPDE_III_ADC; cd06830 755731009031 dimer interface [polypeptide binding]; other site 755731009032 active site 755731009033 pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site 755731009034 catalytic residues [active] 755731009035 Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzymes; Region: PLPDE_III; cl00261 755731009036 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 755731009037 H+ Antiporter protein; Region: 2A0121; TIGR00900 755731009038 putative substrate translocation pore; other site 755731009039 Arabinose efflux permease [Carbohydrate transport and metabolism]; Region: AraJ; COG2814 755731009040 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 755731009041 putative substrate translocation pore; other site 755731009042 H+ Antiporter protein; Region: 2A0121; TIGR00900 755731009043 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 755731009044 putative substrate translocation pore; other site 755731009045 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 755731009046 H+ Antiporter protein; Region: 2A0121; TIGR00900 755731009047 putative substrate translocation pore; other site 755731009048 ApbE family; Region: ApbE; pfam02424 755731009049 Membrane-associated lipoprotein involved in thiamine biosynthesis [Coenzyme metabolism]; Region: ApbE; COG1477 755731009050 Heptaprenyl diphosphate synthase component I; Region: Hpre_diP_synt_I; pfam07456 755731009051 N-Utilization Substance G (NusG) N terminal (NGN) insert and Lin0431 are part of DUF1312; Region: DUF1312; cd09846 755731009052 1,4-dihydroxy-2-naphthoate octaprenyltransferase [Coenzyme metabolism]; Region: MenA; cl17224 755731009053 UbiA prenyltransferase family; Region: UbiA; pfam01040 755731009054 NADH dehydrogenase, FAD-containing subunit [Energy production and conversion]; Region: Ndh; COG1252 755731009055 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 755731009056 Predicted glycosyl hydrolase [General function prediction only]; Region: COG3858 755731009057 Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118 755731009058 Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118 755731009059 Cortical fragment-lytic enzyme (CFLE) is a peptidoglycan hydrolase involved in bacterial endospore germination. CFLE is expressed as an inactive preprotein (called SleB) in the forespore compartment of sporulating cells. SleB translocates across the...; Region: GH18_CFLE_spore_hydrolase; cd02874 755731009060 active site 755731009061 Metallo-beta-lactamase superfamily; Region: Lactamase_B; smart00849 755731009062 Glutathione-dependent formaldehyde dehydrogenase related proteins, child 1; Region: FDH_like_1; cd08283 755731009063 Threonine dehydrogenase and related Zn-dependent dehydrogenases [Amino acid transport and metabolism / General function prediction only]; Region: Tdh; COG1063 755731009064 NAD binding site [chemical binding]; other site 755731009065 catalytic Zn binding site [ion binding]; other site 755731009066 structural Zn binding site [ion binding]; other site 755731009067 Manganese catalase, ferritin-like diiron-binding domain; Region: Mn_catalase; cd01051 755731009068 Ferritin-like domain; Region: Ferritin; pfam00210 755731009069 dimanganese center [ion binding]; other site 755731009070 AAA domain; Region: AAA_33; pfam13671 755731009071 Bacterial transcription activator, effector binding domain; Region: AraC_E_bind; smart00871 755731009072 Protein of unknown function (DUF1646); Region: DUF1646; pfam07854 755731009073 hybrid cluster protein-associated redox disulfide domain; Region: prismane_assoc; TIGR03980 755731009074 NADH:flavin oxidoreductases, Old Yellow Enzyme family [Energy production and conversion]; Region: NemA; COG1902 755731009075 Old yellow enzyme (OYE)-like FMN binding domain. OYE was the first flavin-dependent enzyme identified, however its true physiological role remains elusive to this day. Each monomer of OYE contains FMN as a non-covalently bound cofactor, uses NADPH as a...; Region: OYE_like_FMN_family; cd02803 755731009076 active site 755731009077 FMN binding site [chemical binding]; other site 755731009078 substrate binding site [chemical binding]; other site 755731009079 putative catalytic residue [active] 755731009080 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 755731009081 dimerization interface [polypeptide binding]; other site 755731009082 putative DNA binding site [nucleotide binding]; other site 755731009083 putative Zn2+ binding site [ion binding]; other site 755731009084 Phage Tail Collar Domain; Region: Collar; pfam07484 755731009085 Phage Tail Collar Domain; Region: Collar; pfam07484 755731009086 Phage Tail Collar Domain; Region: Collar; pfam07484 755731009087 Microcystin-dependent protein [Function unknown]; Region: MdpB; COG4675 755731009088 Four helix bundle sensory module for signal transduction; Region: 4HB_MCP_1; pfam12729 755731009089 Methyl-accepting chemotaxis protein [Cell motility and secretion / Signal transduction mechanisms]; Region: Tar; COG0840 755731009090 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 755731009091 dimerization interface [polypeptide binding]; other site 755731009092 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 755731009093 dimer interface [polypeptide binding]; other site 755731009094 putative CheW interface [polypeptide binding]; other site 755731009095 ThiaminS ubiquitin-like sulfur carrier protein; Region: ThiS; cd00565 755731009096 thiS-thiF/thiG interaction site; other site 755731009097 ThiS-like ubiquitin; Region: ThiS-like; pfam14453 755731009098 thiamine biosynthesis protein ThiF; Provisional; Region: PRK08644 755731009099 E1_ThiF_like. Member of superfamily of activating enzymes (E1) of the ubiquitin-like proteins. The common reaction mechanism catalyzed by E1-like enzymes begins with a nucleophilic attack of the C-terminal carboxylate of the ubiquitin-like substrate, on...; Region: E1_ThiF_like; cd01487 755731009100 putative ATP binding site [chemical binding]; other site 755731009101 putative substrate interface [chemical binding]; other site 755731009102 Thiazole synthase (ThiG) is the tetrameric enzyme that is involved in the formation of the thiazole moiety of thiamin pyrophosphate, an essential ubiquitous cofactor that plays an important role in carbohydrate and amino acid metabolism. ThiG catalyzes...; Region: ThiG; cd04728 755731009103 ThiS interaction site; other site 755731009104 putative active site [active] 755731009105 tetramer interface [polypeptide binding]; other site 755731009106 thiamine biosynthesis protein ThiH; Reviewed; Region: thiH; PRK09240 755731009107 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cl15377 755731009108 FeS/SAM binding site; other site 755731009109 Biotin and Thiamin Synthesis associated domain; Region: BATS; smart00876 755731009110 Thiamine monophosphate synthase (TMP synthase)/TenI. TMP synthase catalyzes an important step in the thiamine biosynthesis pathway, the substitution of the pyrophosphate of 2-methyl-4-amino-5- hydroxymethylpyrimidine pyrophosphate by 4-methyl-5-; Region: TMP_TenI; cd00564 755731009111 thiamine phosphate binding site [chemical binding]; other site 755731009112 active site 755731009113 pyrophosphate binding site [ion binding]; other site 755731009114 Predicted transcriptional regulators [Transcription]; Region: COG1695 755731009115 Transcriptional regulator PadR-like family; Region: PadR; pfam03551 755731009116 flavodoxin; Provisional; Region: PRK06242 755731009117 4Fe-4S dicluster domain; Region: Fer4_9; pfam13187 755731009118 Vi polysaccharide biosynthesis protein TviB; Provisional; Region: PRK15182 755731009119 UDP-glucose/GDP-mannose dehydrogenase family, central domain; Region: UDPG_MGDP_dh; pfam00984 755731009120 UDP binding domain; Region: UDPG_MGDP_dh_C; smart00984 755731009121 Dockerin type I repeat; Region: Dockerin_1; pfam00404 755731009122 Fn3 associated; Region: Fn3_assoc; pfam13287 755731009123 CotH protein; Region: CotH; pfam08757 755731009124 GyrI-like small molecule binding domain; Region: GyrI-like; cl01368 755731009125 Metallo-beta-lactamase superfamily; Region: Lactamase_B; pfam00753 755731009126 Endoglucanase [Carbohydrate transport and metabolism]; Region: BglC; COG2730 755731009127 Cellulase (glycosyl hydrolase family 5); Region: Cellulase; pfam00150 755731009128 Dockerin type I repeat; Region: Dockerin_1; pfam00404 755731009129 Dockerin type I repeat; Region: Dockerin_1; pfam00404 755731009130 methionyl-tRNA synthetase; Reviewed; Region: PRK12267 755731009131 catalytic core domain of methioninyl-tRNA synthetases; Region: MetRS_core; cd00814 755731009132 active site 755731009133 HIGH motif; other site 755731009134 KMSKS motif; other site 755731009135 Anticodon-binding domain of methionyl tRNA synthetases; Region: Anticodon_Ia_Met; cd07957 755731009136 tRNA binding surface [nucleotide binding]; other site 755731009137 anticodon binding site; other site 755731009138 tRNA-binding-domain-containing Escherichia coli methionyl-tRNA synthetase (EcMetRS)-like proteins. This family includes EcMetRS and Aquifex aeolicus Trbp111 (AaTrbp111). This domain has general tRNA binding properties. MetRS aminoacylates methionine...; Region: tRNA_bind_EcMetRS_like; cd02800 755731009139 dimer interface [polypeptide binding]; other site 755731009140 putative tRNA-binding site [nucleotide binding]; other site 755731009141 This group contains class II terpene cyclases, protein prenyltransferases beta subunit, two broadly specific proteinase inhibitors alpha2-macroglobulin (alpha (2)-M) and pregnancy zone protein (PZP) and, the C3 C4 and C5 components of vertebrate...; Region: ISOPREN_C2_like; cl08267 755731009142 Prenyltransferase-like; Region: Prenyltrans_2; pfam13249 755731009143 This group contains class II terpene cyclases, protein prenyltransferases beta subunit, two broadly specific proteinase inhibitors alpha2-macroglobulin (alpha (2)-M) and pregnancy zone protein (PZP) and, the C3 C4 and C5 components of vertebrate...; Region: ISOPREN_C2_like; cd00688 755731009144 Prenyltransferase-like; Region: Prenyltrans_2; pfam13249 755731009145 Streptogramin lyase [Defense mechanisms]; Region: Vgb; COG4257 755731009146 Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all...; Region: FN3; cd00063 755731009147 Interdomain contacts; other site 755731009148 Cytokine receptor motif; other site 755731009149 Kelch motif; Region: Kelch_1; pfam01344 755731009150 Galactose oxidase, central domain; Region: Kelch_4; pfam13418 755731009151 Galactose oxidase, central domain; Region: Kelch_4; pfam13418 755731009152 Kelch motif; Region: Kelch_1; pfam01344 755731009153 Kelch domain; Region: Kelch; smart00612 755731009154 Kelch motif; Region: Kelch_1; pfam01344 755731009155 Galactose oxidase, central domain; Region: Kelch_3; cl02701 755731009156 Kelch motif; Region: Kelch_1; pfam01344 755731009157 Protein of unknown function (DUF2793); Region: DUF2793; pfam10983 755731009158 Methyladenine glycosylase; Region: Adenine_glyco; pfam03352 755731009159 Predicted Zn-dependent hydrolases of the beta-lactamase fold [General function prediction only]; Region: COG2220 755731009160 Beta-lactamase superfamily domain; Region: Lactamase_B_3; pfam13483 755731009161 ABC-type enterobactin transport system, permease component [Inorganic ion transport and metabolism]; Region: FepG; COG4779 755731009162 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550 755731009163 ABC-ATPase subunit interface; other site 755731009164 dimer interface [polypeptide binding]; other site 755731009165 putative PBP binding regions; other site 755731009166 ABC-type cobalamin/Fe3+-siderophores transport systems, ATPase components [Inorganic ion transport and metabolism / Coenzyme metabolism]; Region: FepC; COG1120 755731009167 ATP-binding component of iron-siderophores, vitamin B12 and hemin transporters and related proteins; Region: ABC_Iron-Siderophores_B12_Hemin; cd03214 755731009168 Walker A/P-loop; other site 755731009169 ATP binding site [chemical binding]; other site 755731009170 Q-loop/lid; other site 755731009171 ABC transporter signature motif; other site 755731009172 Walker B; other site 755731009173 D-loop; other site 755731009174 H-loop/switch region; other site 755731009175 ABC-type Fe3+-hydroxamate transport system, periplasmic component [Inorganic ion transport and metabolism]; Region: FepB; COG0614 755731009176 Helical backbone metal receptor (TroA-like domain). These proteins have been shown to function in the ABC transport of ferric siderophores and metal ions such as Mn2+, Fe3+, Cu2+ and/or Zn2+. Their ligand binding site is formed in the interface between...; Region: TroA-like; cl00262 755731009177 intersubunit interface [polypeptide binding]; other site 755731009178 dTDP-D-glucose 4,6-dehydratase [Cell envelope biogenesis, outer membrane]; Region: RfbB; COG1088 755731009179 dTDP-D-glucose 4,6-dehydratase, extended (e) SDRs; Region: dTDP_GD_SDR_e; cd05246 755731009180 NAD binding site [chemical binding]; other site 755731009181 substrate binding site [chemical binding]; other site 755731009182 homodimer interface [polypeptide binding]; other site 755731009183 active site 755731009184 TIM barrel proteins share a structurally conserved phosphate binding motif and in general share an eight beta/alpha closed barrel structure. Specific for this family is the conserved phosphate binding site at the edges of strands 7 and 8. The phosphate...; Region: TIM_phosphate_binding; cl17186 755731009185 phosphate binding site [ion binding]; other site 755731009186 NADPH-dependent butanol dehydrogenase involved in the butanol and ethanol formation pathway in bacteria; Region: NADPH_BDH; cd08179 755731009187 Alcohol dehydrogenase, class IV [Energy production and conversion]; Region: EutG; COG1454 755731009188 putative active site [active] 755731009189 metal binding site [ion binding]; metal-binding site 755731009190 TIM barrel proteins share a structurally conserved phosphate binding motif and in general share an eight beta/alpha closed barrel structure. Specific for this family is the conserved phosphate binding site at the edges of strands 7 and 8. The phosphate...; Region: TIM_phosphate_binding; cd04722 755731009191 phosphate binding site [ion binding]; other site 755731009192 Uridine phosphorylase [Nucleotide transport and metabolism]; Region: Udp; COG2820 755731009193 Phosphorylase superfamily; Region: PNP_UDP_1; cl00303 755731009194 Sugar kinases, ribokinase family [Carbohydrate transport and metabolism]; Region: RbsK; COG0524 755731009195 ribokinase/pfkB superfamily: Kinases that accept a wide variety of substrates, including carbohydrates and aromatic small molecules, all are phosphorylated at a hydroxyl group. The superfamily includes ribokinase, fructokinase, ketohexokinase; Region: ribokinase_pfkB_like; cl00192 755731009196 substrate binding site [chemical binding]; other site 755731009197 ATP binding site [chemical binding]; other site 755731009198 Isochorismatase family; Region: Isochorismatase; pfam00857 755731009199 Cysteine hydrolases; This family contains amidohydrolases, like CSHase (N-carbamoylsarcosine amidohydrolase), involved in creatine metabolism and nicotinamidase, converting nicotinamide to nicotinic acid and ammonia in the pyridine nucleotide cycle. It...; Region: cysteine_hydrolases; cd00431 755731009200 catalytic triad [active] 755731009201 conserved cis-peptide bond; other site 755731009202 Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653 755731009203 Transmembrane subunit (TM) of Treponema pallidum (Tp) RbsC-1, RbsC-2 and related proteins. This is a functionally uncharacterized subgroup of TMs which belong to a larger group of TMs of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette; Region: TM_PBP1_transp_TpRbsC_like; cd06580 755731009204 TM-ABC transporter signature motif; other site 755731009205 Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653 755731009206 Transmembrane subunit (TM) of Treponema pallidum (Tp) RbsC-1, RbsC-2 and related proteins. This is a functionally uncharacterized subgroup of TMs which belong to a larger group of TMs of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette; Region: TM_PBP1_transp_TpRbsC_like; cd06580 755731009207 TM-ABC transporter signature motif; other site 755731009208 ABC-type uncharacterized transport systems, ATPase components [General function prediction only]; Region: COG3845 755731009209 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 755731009210 Walker A/P-loop; other site 755731009211 ATP binding site [chemical binding]; other site 755731009212 Q-loop/lid; other site 755731009213 ABC transporter signature motif; other site 755731009214 Walker B; other site 755731009215 D-loop; other site 755731009216 H-loop/switch region; other site 755731009217 Second domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_II; cd03215 755731009218 Periplasmic binding domain of basic membrane lipoprotein, PnrA, in Treponema pallidum and its homologs from other bacteria and Archaea; Region: PBP1_BmpA_PnrA_like; cd06354 755731009219 ligand binding site [chemical binding]; other site 755731009220 Uncharacterized ABC-type transport system, periplasmic component/surface lipoprotein [General function prediction only]; Region: Med; COG1744 755731009221 Transcriptional regulators [Transcription]; Region: PhnF; COG2188 755731009222 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 755731009223 DNA-binding site [nucleotide binding]; DNA binding site 755731009224 UTRA domain; Region: UTRA; pfam07702 755731009225 Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118 755731009226 Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653 755731009227 Transmembrane subunit (TM) of Treponema pallidum (Tp) RbsC-1, RbsC-2 and related proteins. This is a functionally uncharacterized subgroup of TMs which belong to a larger group of TMs of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette; Region: TM_PBP1_transp_TpRbsC_like; cd06580 755731009228 TM-ABC transporter signature motif; other site 755731009229 Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653 755731009230 Transmembrane subunit (TM) of Treponema pallidum (Tp) RbsC-1, RbsC-2 and related proteins. This is a functionally uncharacterized subgroup of TMs which belong to a larger group of TMs of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette; Region: TM_PBP1_transp_TpRbsC_like; cd06580 755731009231 Transmembrane subunit (TM) of Treponema pallidum (Tp) RbsC-1, RbsC-2 and related proteins. This is a functionally uncharacterized subgroup of TMs which belong to a larger group of TMs of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette; Region: TM_PBP1_transp_TpRbsC_like; cd06580 755731009232 TM-ABC transporter signature motif; other site 755731009233 ABC-type uncharacterized transport systems, ATPase components [General function prediction only]; Region: COG3845 755731009234 First domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_I; cd03216 755731009235 Walker A/P-loop; other site 755731009236 ATP binding site [chemical binding]; other site 755731009237 Q-loop/lid; other site 755731009238 ABC transporter signature motif; other site 755731009239 Walker B; other site 755731009240 D-loop; other site 755731009241 H-loop/switch region; other site 755731009242 Second domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_II; cd03215 755731009243 Uncharacterized ABC-type transport system, periplasmic component/surface lipoprotein [General function prediction only]; Region: Med; COG1744 755731009244 Periplasmic binding domain of basic membrane lipoprotein, PnrA, in Treponema pallidum and its homologs from other bacteria and Archaea; Region: PBP1_BmpA_PnrA_like; cd06354 755731009245 ligand binding site [chemical binding]; other site 755731009246 Predicted phosphatases [General function prediction only]; Region: Gph; COG0546 755731009247 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 755731009248 motif II; other site 755731009249 Uncharacterized membrane protein [Function unknown]; Region: SapB; COG1285 755731009250 MgtC family; Region: MgtC; pfam02308 755731009251 Glycerophosphoryl diester phosphodiesterase [Energy production and conversion]; Region: UgpQ; COG0584 755731009252 Glycerophosphodiester phosphodiesterase domain of putative Agrobacterium tumefaciens glycerophosphodiester phosphodiesterase and similar proteins; Region: GDPD_pAtGDE_like; cd08565 755731009253 active site 755731009254 catalytic site [active] 755731009255 metal binding site [ion binding]; metal-binding site 755731009256 ribulokinase; Provisional; Region: PRK04123 755731009257 Ribulokinases; belongs to the FGGY family of carbohydrate kinases; Region: FGGY_RBK; cd07781 755731009258 N- and C-terminal domain interface [polypeptide binding]; other site 755731009259 active site 755731009260 MgATP binding site [chemical binding]; other site 755731009261 catalytic site [active] 755731009262 metal binding site [ion binding]; metal-binding site 755731009263 carbohydrate binding site [chemical binding]; other site 755731009264 homodimer interface [polypeptide binding]; other site 755731009265 Threonine dehydrogenase and related Zn-dependent dehydrogenases [Amino acid transport and metabolism / General function prediction only]; Region: Tdh; COG1063 755731009266 Alcohol dehydrogenases of the MDR family; Region: Zn_ADH2; cd08256 755731009267 putative NAD(P) binding site [chemical binding]; other site 755731009268 catalytic Zn binding site [ion binding]; other site 755731009269 structural Zn binding site [ion binding]; other site 755731009270 Sugar phosphate isomerases/epimerases [Carbohydrate transport and metabolism]; Region: IolE; COG1082 755731009271 AP endonuclease family 2; These endonucleases play a role in DNA repair. Cleave phosphodiester bonds at apurinic or apyrimidinic sites; the alignment also contains hexulose-6-phosphate isomerases, enzymes that catalyze the epimerization of...; Region: AP2Ec; cl12060 755731009272 Metal-binding active site; metal-binding site 755731009273 Xylose isomerase-like TIM barrel; Region: AP_endonuc_2; pfam01261 755731009274 AP endonuclease family 2; These endonucleases play a role in DNA repair. Cleave phosphodiester bonds at apurinic or apyrimidinic sites; the alignment also contains hexulose-6-phosphate isomerases, enzymes that catalyze the epimerization of...; Region: AP2Ec; cl12060 755731009275 Metal-binding active site; metal-binding site 755731009276 ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653 755731009277 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; cl17199 755731009278 ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395 755731009279 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 755731009280 dimer interface [polypeptide binding]; other site 755731009281 conserved gate region; other site 755731009282 ABC-ATPase subunit interface; other site 755731009283 ABC-type sulfate transport system, permease component [Posttranslational modification, protein turnover, chaperones]; Region: CysU; COG0555 755731009284 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 755731009285 dimer interface [polypeptide binding]; other site 755731009286 conserved gate region; other site 755731009287 putative PBP binding loops; other site 755731009288 ABC-ATPase subunit interface; other site 755731009289 Transcriptional regulators [Transcription]; Region: PurR; COG1609 755731009290 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 755731009291 DNA binding site [nucleotide binding] 755731009292 domain linker motif; other site 755731009293 Ligand binding domain of the LacI tanscriptional regulator family belonging to the type I periplasmic-binding fold protein superfamily; Region: PBP1_LacI_sugar_binding_like; cd06267 755731009294 dimerization interface [polypeptide binding]; other site 755731009295 ligand binding site [chemical binding]; other site 755731009296 FAD dependent oxidoreductase; Region: FAD_oxidored; pfam12831 755731009297 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 755731009298 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 755731009299 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 755731009300 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3708 755731009301 Low molecular weight phosphatase family; Region: LMWPc; cl00105 755731009302 Protein-tyrosine-phosphatase [Signal transduction mechanisms]; Region: Wzb; COG0394 755731009303 active site 755731009304 Thioredoxin domain; Region: Thioredoxin_3; pfam13192 755731009305 Predicted permeases [General function prediction only]; Region: COG0701 755731009306 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 755731009307 dimerization interface [polypeptide binding]; other site 755731009308 putative DNA binding site [nucleotide binding]; other site 755731009309 putative Zn2+ binding site [ion binding]; other site 755731009310 peptide modification radical SAM enzyme, YydG family; Region: rSAM_yydG; TIGR04078 755731009311 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 755731009312 FeS/SAM binding site; other site 755731009313 NADPH-dependent FMN reductase; Region: FMN_red; pfam03358 755731009314 Multimeric flavodoxin WrbA [General function prediction only]; Region: WrbA; COG0655 755731009315 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 755731009316 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 755731009317 Walker A/P-loop; other site 755731009318 ATP binding site [chemical binding]; other site 755731009319 ABC transporter; Region: ABC_tran; pfam00005 755731009320 Q-loop/lid; other site 755731009321 ABC transporter signature motif; other site 755731009322 Walker B; other site 755731009323 D-loop; other site 755731009324 H-loop/switch region; other site 755731009325 Methylase of polypeptide chain release factors [Translation, ribosomal structure and biogenesis]; Region: HemK; COG2890 755731009326 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 755731009327 S-adenosylmethionine binding site [chemical binding]; other site 755731009328 Coenzyme PQQ synthesis protein D (PqqD); Region: PqqD; cl05126 755731009329 Predicted Fe-S oxidoreductases [General function prediction only]; Region: COG0535 755731009330 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 755731009331 FeS/SAM binding site; other site 755731009332 B12-binding domain/radical SAM domain protein, MJ_1487 family; Region: B12_SAM_MJ_1487; TIGR04013 755731009333 B12 binding domain_like associated with radical SAM domain. This domain shows similarity with B12 (adenosylcobamide) binding domains found in several enzymes, such as glutamate mutase, methionine synthase and methylmalonyl-CoA mutase, but it lacks the...; Region: radical_SAM_B12_BD; cd02068 755731009334 ABC-type Na+ transport system, ATPase component [Energy production and conversion / Inorganic ion transport and metabolism]; Region: NatA; COG4555 755731009335 ATP-binding cassette domain of the drug resistance transporter and related proteins, subfamily A; Region: ABC_DR_subfamily_A; cd03230 755731009336 Walker A/P-loop; other site 755731009337 ATP binding site [chemical binding]; other site 755731009338 Q-loop/lid; other site 755731009339 ABC transporter signature motif; other site 755731009340 Walker B; other site 755731009341 D-loop; other site 755731009342 H-loop/switch region; other site 755731009343 Protein of unknown function (DUF1648); Region: DUF1648; pfam07853 755731009344 Peptidase S8 family domain in Subtilisin-like proteins; Region: Peptidases_S8_Subtilisin_like; cd07473 755731009345 catalytic triad [active] 755731009346 putative active site [active] 755731009347 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 755731009348 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 755731009349 non-specific DNA binding site [nucleotide binding]; other site 755731009350 salt bridge; other site 755731009351 sequence-specific DNA binding site [nucleotide binding]; other site 755731009352 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 755731009353 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 755731009354 non-specific DNA binding site [nucleotide binding]; other site 755731009355 salt bridge; other site 755731009356 sequence-specific DNA binding site [nucleotide binding]; other site 755731009357 cyclic lactone autoinducer peptide; Region: quorum_AgrD; TIGR04223 755731009358 Accessory gene regulator B; Region: AgrB; pfam04647 755731009359 Acetyltransferase (GNAT) domain; Region: Acetyltransf_3; pfam13302 755731009360 Acetyltransferase (GNAT) family; Region: Acetyltransf_1; pfam00583 755731009361 SGNH_hydrolase, or GDSL_hydrolase, is a diverse family of lipases and esterases. The tertiary fold of the enzyme is substantially different from that of the alpha/beta hydrolase family and unique among all known hydrolases; its active site closely...; Region: SGNH_hydrolase; cd00229 755731009362 active site 755731009363 catalytic triad [active] 755731009364 oxyanion hole [active] 755731009365 Dockerin type I repeat; Region: Dockerin_1; pfam00404 755731009366 Dockerin type I repeat; Region: Dockerin_1; pfam00404 755731009367 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 755731009368 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 755731009369 SGNH_hydrolase, or GDSL_hydrolase, is a diverse family of lipases and esterases. The tertiary fold of the enzyme is substantially different from that of the alpha/beta hydrolase family and unique among all known hydrolases; its active site closely...; Region: SGNH_hydrolase; cl01053 755731009370 active site 755731009371 catalytic triad [active] 755731009372 oxyanion hole [active] 755731009373 Class I aldolases; Region: Aldolase_Class_I; cl17187 755731009374 Dihydrodipicolinate synthase/N-acetylneuraminate lyase [Amino acid transport and metabolism / Cell envelope biogenesis, outer membrane]; Region: DapA; COG0329 755731009375 catalytic residue [active] 755731009376 ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395 755731009377 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 755731009378 dimer interface [polypeptide binding]; other site 755731009379 conserved gate region; other site 755731009380 putative PBP binding loops; other site 755731009381 ABC-ATPase subunit interface; other site 755731009382 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 755731009383 dimer interface [polypeptide binding]; other site 755731009384 conserved gate region; other site 755731009385 putative PBP binding loops; other site 755731009386 ABC-ATPase subunit interface; other site 755731009387 ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653 755731009388 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; pfam01547 755731009389 N-acetylmannosamine-6-phosphate epimerase (NanE) converts N-acetylmannosamine-6-phosphate to N-acetylglucosamine-6-phosphate. This reaction is part of the pathway that allows the usage of sialic acid as a carbohydrate source. Sialic acids are a family of...; Region: NanE; cd04729 755731009390 N-acetylmannosamine-6-phosphate 2-epimerase; Provisional; Region: PRK01130 755731009391 putative active site cavity [active] 755731009392 Transcriptional regulators [Transcription]; Region: PhnF; COG2188 755731009393 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 755731009394 DNA-binding site [nucleotide binding]; DNA binding site 755731009395 UTRA domain; Region: UTRA; pfam07702 755731009396 Domain of unknown function (DUF386); Region: DUF386; cl01047 755731009397 Transcriptional regulator/sugar kinase [Transcription / Carbohydrate transport and metabolism]; Region: NagC; COG1940 755731009398 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cd00012 755731009399 nucleotide binding site [chemical binding]; other site 755731009400 6-phosphogluconolactonase/Glucosamine-6-phosphate isomerase/deaminase [Carbohydrate transport and metabolism]; Region: NagB; COG0363 755731009401 GlcN6P_deaminase: Glucosamine-6-phosphate (GlcN6P) deaminase subfamily; GlcN6P deaminase catalyzes the reversible conversion of GlcN6P to D-fructose-6-phosphate (Fru6P) and ammonium. The reaction is an aldo-keto isomerization coupled with an amination or...; Region: GlcN6P_deaminase; cd01399 755731009402 active site 755731009403 trimer interface [polypeptide binding]; other site 755731009404 allosteric site; other site 755731009405 active site lid [active] 755731009406 hexamer (dimer of trimers) interface [polypeptide binding]; other site 755731009407 N-acetylglucosamine-6-phosphate deacetylase [Carbohydrate transport and metabolism]; Region: NagA; COG1820 755731009408 N-acetylglucosamine-6-phosphate deacetylase, NagA, catalyzes the hydrolysis of the N-acetyl group of N-acetyl-glucosamine-6-phosphate (GlcNAc-6-P) to glucosamine 6-phosphate and acetate. This is the first committed step in the biosynthetic pathway to...; Region: NagA; cd00854 755731009409 active site 755731009410 dimer interface [polypeptide binding]; other site 755731009411 Sugar kinases, ribokinase family [Carbohydrate transport and metabolism]; Region: RbsK; COG0524 755731009412 Fructokinases (FRKs) mainly from bacteria and plants are enzymes with high specificity for fructose, as are all FRKs, but they catalyzes the conversion of fructose to fructose-6-phosphate, which is an entry point into glycolysis via conversion into...; Region: bac_FRK; cd01167 755731009413 putative substrate binding site [chemical binding]; other site 755731009414 putative ATP binding site [chemical binding]; other site 755731009415 Threonine dehydrogenase and related Zn-dependent dehydrogenases [Amino acid transport and metabolism / General function prediction only]; Region: Tdh; COG1063 755731009416 Alcohol dehydrogenases of the MDR family; Region: Zn_ADH7; cd08261 755731009417 putative NAD(P) binding site [chemical binding]; other site 755731009418 catalytic Zn binding site [ion binding]; other site 755731009419 structural Zn binding site [ion binding]; other site 755731009420 AP endonuclease family 2; These endonucleases play a role in DNA repair. Cleave phosphodiester bonds at apurinic or apyrimidinic sites; the alignment also contains hexulose-6-phosphate isomerases, enzymes that catalyze the epimerization of...; Region: AP2Ec; cl12060 755731009421 Xylose isomerase-like TIM barrel; Region: AP_endonuc_2; pfam01261 755731009422 AP (apurinic/apyrimidinic) site pocket; other site 755731009423 DNA interaction; other site 755731009424 Metal-binding active site; metal-binding site 755731009425 AP endonuclease family 2 C terminus; Region: AP_endonuc_2_N; pfam07582 755731009426 ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395 755731009427 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 755731009428 dimer interface [polypeptide binding]; other site 755731009429 conserved gate region; other site 755731009430 putative PBP binding loops; other site 755731009431 ABC-ATPase subunit interface; other site 755731009432 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 755731009433 dimer interface [polypeptide binding]; other site 755731009434 conserved gate region; other site 755731009435 putative PBP binding loops; other site 755731009436 ABC-ATPase subunit interface; other site 755731009437 ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653 755731009438 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; pfam01547 755731009439 Response regulator receiver domain; Region: Response_reg; pfam00072 755731009440 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 755731009441 active site 755731009442 phosphorylation site [posttranslational modification] 755731009443 intermolecular recognition site; other site 755731009444 dimerization interface [polypeptide binding]; other site 755731009445 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 755731009446 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 755731009447 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 755731009448 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cl01054 755731009449 dimerization interface [polypeptide binding]; other site 755731009450 Histidine kinase; Region: His_kinase; pfam06580 755731009451 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 755731009452 Mg2+ binding site [ion binding]; other site 755731009453 G-X-G motif; other site 755731009454 Sensory domain found in PocR; Region: PocR; pfam10114 755731009455 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 755731009456 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 755731009457 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 755731009458 FAD dependent oxidoreductase; Region: FAD_oxidored; pfam12831 755731009459 FAD dependent oxidoreductase; Region: FAD_oxidored; pfam12831 755731009460 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450 755731009461 geranylgeranyl reductase family; Region: GG-red-SF; TIGR02032 755731009462 Dehydrogenases (flavoproteins) [Energy production and conversion]; Region: FixC; COG0644 755731009463 putative FAD-binding dehydrogenase; Reviewed; Region: PRK12834 755731009464 Ferredoxin-dependent bilin reductase; Region: Fe_bilin_red; cl07930 755731009465 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394 755731009466 active site 755731009467 ABC-2 family transporter protein; Region: ABC2_membrane_3; pfam12698 755731009468 ABC-type multidrug transport system, ATPase component [Defense mechanisms]; Region: CcmA; COG1131 755731009469 ATP-binding cassette domain of the drug resistance transporter and related proteins, subfamily A; Region: ABC_DR_subfamily_A; cd03230 755731009470 Walker A/P-loop; other site 755731009471 ATP binding site [chemical binding]; other site 755731009472 Q-loop/lid; other site 755731009473 ABC transporter signature motif; other site 755731009474 Walker B; other site 755731009475 D-loop; other site 755731009476 H-loop/switch region; other site 755731009477 Polysaccharide pyruvyl transferase; Region: PS_pyruv_trans; cl09156 755731009478 B12 binding domain (B12-BD). Most of the members bind different cobalamid derivates, like B12 (adenosylcobamide) or methylcobalamin or methyl-Co(III) 5-hydroxybenzimidazolylcobamide. This domain is found in several enzymes, such as glutamate mutase; Region: B12-binding_like; cl00293 755731009479 Elongator protein 3, MiaB family, Radical SAM; Region: Elp3; smart00729 755731009480 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 755731009481 Radical SAM superfamily; Region: Radical_SAM; pfam04055 755731009482 FeS/SAM binding site; other site 755731009483 Domain of unknown function (DUF4008); Region: DUF4008; pfam13186 755731009484 Ribosomally synthesized peptide prototyped by Frankia Franean1_4349; Region: Frankia_peptide; pfam14407 755731009485 Fe-S oxidoreductase [Energy production and conversion]; Region: COG1032 755731009486 B12 binding domain; Region: B12-binding; pfam02310 755731009487 B12 binding site [chemical binding]; other site 755731009488 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 755731009489 Radical SAM superfamily; Region: Radical_SAM; pfam04055 755731009490 FeS/SAM binding site; other site 755731009491 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 755731009492 Radical SAM superfamily; Region: Radical_SAM; pfam04055 755731009493 FeS/SAM binding site; other site 755731009494 Domain of unknown function (DUF4008); Region: DUF4008; pfam13186 755731009495 peptide modification radical SAM enzyme, YydG family; Region: rSAM_yydG; TIGR04078 755731009496 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 755731009497 FeS/SAM binding site; other site 755731009498 peptide modification radical SAM enzyme, YydG family; Region: rSAM_yydG; TIGR04078 755731009499 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 755731009500 FeS/SAM binding site; other site 755731009501 peptide modification radical SAM enzyme, YydG family; Region: rSAM_yydG; TIGR04078 755731009502 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 755731009503 FeS/SAM binding site; other site 755731009504 tungsten cofactor oxidoreducase radical SAM maturase; Region: W_rSAM_matur; TIGR04317 755731009505 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 755731009506 FeS/SAM binding site; other site 755731009507 radical SAM additional 4Fe4S-binding SPASM domain; Region: rSAM_more_4Fe4S; TIGR04085 755731009508 NAD(P)H:flavin oxidoreductase-like family 1. A subfamily of the nitroreductase family containing uncharacterized proteins that are similar to nitroreductase. Nitroreductase catalyzes the reduction of nitroaromatic compounds such as nitrotoluenes; Region: NADPH_oxidoreductase_1; cd02150 755731009509 putative FMN binding site [chemical binding]; other site 755731009510 tRNA-dihydrouridine synthase [Translation, ribosomal structure and biogenesis]; Region: COG0042 755731009511 Dihydrouridine synthase-like (DUS-like) FMN-binding domain. Members of this family catalyze the reduction of the 5,6-double bond of a uridine residue on tRNA. Dihydrouridine modification of tRNA is widely observed in prokaryotes and eukaryotes, and also...; Region: DUS_like_FMN; cd02801 755731009512 FMN binding site [chemical binding]; other site 755731009513 active site 755731009514 catalytic residues [active] 755731009515 substrate binding site [chemical binding]; other site 755731009516 Translation elongation factors (GTPases) [Translation, ribosomal structure and biogenesis]; Region: FusA; COG0480 755731009517 Tet(M)-like family includes Tet(M), Tet(O), Tet(W), and OtrA, containing tetracycline resistant proteins; Region: TetM_like; cd04168 755731009518 G1 box; other site 755731009519 putative GEF interaction site [polypeptide binding]; other site 755731009520 GTP/Mg2+ binding site [chemical binding]; other site 755731009521 Switch I region; other site 755731009522 G2 box; other site 755731009523 G3 box; other site 755731009524 Switch II region; other site 755731009525 G4 box; other site 755731009526 G5 box; other site 755731009527 Translation_Factor_II_like: Elongation factor Tu (EF-Tu) domain II-like proteins. Elongation factor Tu consists of three structural domains, this family represents the second domain. Domain II adopts a beta barrel structure and is involved in binding to...; Region: Translation_Factor_II_like; cl02787 755731009528 Elongation Factor G-like domain IV. This family includes the translational elongation factor termed EF-2 (for Archaea and Eukarya) and EF-G (for Bacteria), ribosomal protection proteins that mediate tetracycline resistance and, an evolutionarily...; Region: EFG_like_IV; cl02789 755731009529 Tet_C: C-terminus of ribosomal protection proteins Tet(M) and Tet(O). This domain has homology to the C terminal domains of the elongation factors EF-G and EF-2. Tet(M) and Tet(O) catalyze the release of tetracycline (Tc) from the ribosome in a...; Region: Tet_C; cd03711 755731009530 YacP-like NYN domain; Region: NYN_YacP; pfam05991 755731009531 Regulator of chromosome condensation (RCC1) repeat; Region: RCC1_2; pfam13540 755731009532 Regulator of chromosome condensation (RCC1) repeat; Region: RCC1_2; pfam13540 755731009533 Regulator of chromosome condensation (RCC1) repeat; Region: RCC1_2; pfam13540 755731009534 Regulator of chromosome condensation (RCC1) repeat; Region: RCC1_2; pfam13540 755731009535 Regulator of chromosome condensation (RCC1) repeat; Region: RCC1_2; pfam13540 755731009536 Regulator of chromosome condensation (RCC1) repeat; Region: RCC1_2; pfam13540 755731009537 Domain of unknown function (DUF4157); Region: DUF4157; pfam13699 755731009538 DNA/RNA non-specific endonuclease; Region: Endonuclea_NS_2; cl17626 755731009539 Helix-Turn-Helix DNA binding domain of transcription regulators from the MerR superfamily; Region: HTH_MerR-SF; cl02600 755731009540 MerR HTH family regulatory protein; Region: MerR_1; pfam13411 755731009541 DNA binding residues [nucleotide binding] 755731009542 Bacterial transcription activator, effector binding domain; Region: AraC_E_bind; smart00871 755731009543 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 755731009544 Major Facilitator Superfamily; Region: MFS_1; pfam07690 755731009545 putative substrate translocation pore; other site 755731009546 Transcriptional regulators [Transcription]; Region: PurR; COG1609 755731009547 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 755731009548 DNA binding site [nucleotide binding] 755731009549 domain linker motif; other site 755731009550 Ligand binding domain of the LacI tanscriptional regulator family belonging to the type I periplasmic-binding fold protein superfamily; Region: PBP1_LacI_sugar_binding_like; cd06267 755731009551 ligand binding site [chemical binding]; other site 755731009552 Bacterial capsule synthesis protein PGA_cap; Region: PGA_cap; smart00854 755731009553 CapA and related proteins, metallophosphatase domain; Region: MPP_CapA; cd07381 755731009554 putative active site [active] 755731009555 putative metal binding site [ion binding]; other site 755731009556 glutathione transporter ATP-binding protein; Provisional; Region: PRK10261 755731009557 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 755731009558 Walker A/P-loop; other site 755731009559 ATP binding site [chemical binding]; other site 755731009560 Q-loop/lid; other site 755731009561 ABC transporter signature motif; other site 755731009562 Walker B; other site 755731009563 D-loop; other site 755731009564 H-loop/switch region; other site 755731009565 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097 755731009566 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 755731009567 Walker A/P-loop; other site 755731009568 ATP binding site [chemical binding]; other site 755731009569 Q-loop/lid; other site 755731009570 ABC transporter signature motif; other site 755731009571 Walker B; other site 755731009572 D-loop; other site 755731009573 H-loop/switch region; other site 755731009574 oligopeptide/dipeptide ABC transporter, ATP-binding protein, C-terminal domain; Region: oligo_HPY; TIGR01727 755731009575 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppC; COG1173 755731009576 N-terminal TM domain of oligopeptide transport permease C; Region: OppC_N; pfam12911 755731009577 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 755731009578 putative PBP binding loops; other site 755731009579 ABC-ATPase subunit interface; other site 755731009580 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppB; COG0601 755731009581 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 755731009582 dimer interface [polypeptide binding]; other site 755731009583 conserved gate region; other site 755731009584 putative PBP binding loops; other site 755731009585 ABC-ATPase subunit interface; other site 755731009586 The substrate-binding domain of an ABC-type nickel/oligopeptide-like import system contains the type 2 periplasmic binding fold; Region: PBP2_NikA_DppA_OppA_like; cd00995 755731009587 Bacterial extracellular solute-binding proteins, family 5 Middle; Region: SBP_bac_5; pfam00496 755731009588 Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596 755731009589 This conserved domain belongs to a superfamily including the bleomycin resistance protein, glyoxalase I, and type I ring-cleaving dioxygenases; Region: Glo_EDI_BRP_like_3; cd07241 755731009590 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 755731009591 putative metal binding site [ion binding]; other site 755731009592 Carbohydrate Binding Module 6 (CBM6); many are appended to glycoside hydrolase (GH) family 11 and GH43 xylanase domains; Region: CBM6_xylanase-like; cd04084 755731009593 metal binding site [ion binding]; metal-binding site 755731009594 ligand binding site [chemical binding]; other site 755731009595 Dockerin type I repeat; Region: Dockerin_1; pfam00404 755731009596 Dockerin type I repeat; Region: Dockerin_1; pfam00404 755731009597 Mitochondrial biogenesis AIM24; Region: AIM24; pfam01987 755731009598 4-hydroxythreonine-4-phosphate dehydrogenase; Validated; Region: pdxA; PRK03743 755731009599 Pyridoxal phosphate biosynthesis protein [Coenzyme metabolism]; Region: PdxA; COG1995 755731009600 Predicted transcriptional regulators [Transcription]; Region: COG1725 755731009601 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 755731009602 DNA-binding site [nucleotide binding]; DNA binding site 755731009603 ABC-type multidrug transport system, ATPase component [Defense mechanisms]; Region: CcmA; COG1131 755731009604 ATP-binding cassette domain of the drug resistance transporter and related proteins, subfamily A; Region: ABC_DR_subfamily_A; cd03230 755731009605 Walker A/P-loop; other site 755731009606 ATP binding site [chemical binding]; other site 755731009607 Q-loop/lid; other site 755731009608 ABC transporter signature motif; other site 755731009609 Walker B; other site 755731009610 D-loop; other site 755731009611 H-loop/switch region; other site 755731009612 ABC-2 family transporter protein; Region: ABC2_membrane_2; cl17866 755731009613 ABC-2 family transporter protein; Region: ABC2_membrane_4; pfam12730 755731009614 ABC-type multidrug transport system, ATPase component [Defense mechanisms]; Region: CcmA; COG1131 755731009615 ATP-binding cassette domain of the drug resistance transporter and related proteins, subfamily A; Region: ABC_DR_subfamily_A; cd03230 755731009616 Walker A/P-loop; other site 755731009617 ATP binding site [chemical binding]; other site 755731009618 Q-loop/lid; other site 755731009619 ABC transporter signature motif; other site 755731009620 Walker B; other site 755731009621 D-loop; other site 755731009622 H-loop/switch region; other site 755731009623 Predicted transcriptional regulators [Transcription]; Region: COG1725 755731009624 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 755731009625 DNA-binding site [nucleotide binding]; DNA binding site 755731009626 Zinc dependent phospholipase C; Region: Zn_dep_PLPC; pfam00882 755731009627 glycerate kinase; Region: TIGR00045 755731009628 6-phosphofructokinase; Provisional; Region: PRK03202 755731009629 6-phosphofructokinase; Region: PFKA_ATP; TIGR02482 755731009630 active site 755731009631 ADP/pyrophosphate binding site [chemical binding]; other site 755731009632 dimerization interface [polypeptide binding]; other site 755731009633 allosteric effector site; other site 755731009634 fructose-1,6-bisphosphate binding site; other site 755731009635 phosphatidylserine decarboxylase; Provisional; Region: PRK00723 755731009636 Glycosyl hydrolase family 43, includes arabinoxylan arabinofuranohydrolase, beta-xylosidase, endo-1,4-beta-xylanase, alpha-L-arabinofuranosidase; Region: GH43_AXH_like; cd08990 755731009637 substrate binding site [chemical binding]; other site 755731009638 active site 755731009639 Bacterial Ig-like domain (group 4); Region: Big_4; pfam07532 755731009640 Bacterial Ig-like domain (group 4); Region: Big_4; pfam07532 755731009641 Bacterial Ig-like domain (group 4); Region: Big_4; pfam07532 755731009642 Bacterial Ig-like domain (group 4); Region: Big_4; pfam07532 755731009643 Bacterial Ig-like domain (group 4); Region: Big_4; pfam07532 755731009644 Leucine Rich repeats (2 copies); Region: LRR_4; pfam12799 755731009645 Leucine Rich repeats (2 copies); Region: LRR_4; pfam12799 755731009646 Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 residue sequence motifs present in many proteins that participate in protein-protein interactions and have different functions and cellular locations. LRRs correspond...; Region: LRR_RI; cl15309 755731009647 Leucine Rich repeats (2 copies); Region: LRR_4; pfam12799 755731009648 Leucine-rich repeats; other site 755731009649 Leucine Rich repeats (2 copies); Region: LRR_4; pfam12799 755731009650 Leucine Rich repeats (2 copies); Region: LRR_4; pfam12799 755731009651 Leucine Rich repeats (2 copies); Region: LRR_4; pfam12799 755731009652 Transglutaminase-like superfamily; Region: Transglut_core; pfam01841 755731009653 Domain of unknown function (DUF4353); Region: DUF4353; pfam14262 755731009654 Polyphosphate(polyP) polymerase domain of yeast vacuolar transport chaperone (VTC) proteins VTC-2, -3 and- 4, and similar proteins; Region: PolyPPase_VTC_like; cd07750 755731009655 putative metal binding residues [ion binding]; other site 755731009656 signature motif; other site 755731009657 dimer interface [polypeptide binding]; other site 755731009658 active site 755731009659 polyP binding site; other site 755731009660 substrate binding site [chemical binding]; other site 755731009661 acceptor-phosphate pocket; other site 755731009662 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 755731009663 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 755731009664 active site 755731009665 phosphorylation site [posttranslational modification] 755731009666 intermolecular recognition site; other site 755731009667 dimerization interface [polypeptide binding]; other site 755731009668 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 755731009669 DNA binding site [nucleotide binding] 755731009670 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 755731009671 dimer interface [polypeptide binding]; other site 755731009672 phosphorylation site [posttranslational modification] 755731009673 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 755731009674 ATP binding site [chemical binding]; other site 755731009675 Mg2+ binding site [ion binding]; other site 755731009676 G-X-G motif; other site 755731009677 23S rRNA methyltransferase A; Provisional; Region: rrmA; PRK11088 755731009678 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 755731009679 S-adenosylmethionine binding site [chemical binding]; other site 755731009680 Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer); Region: MA; smart00283 755731009681 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 755731009682 dimer interface [polypeptide binding]; other site 755731009683 putative CheW interface [polypeptide binding]; other site 755731009684 Periplasmic sugar-binding domain of active transport systems that are members of the type I periplasmic binding protein (PBP1) superfamily; Region: PBP1_ABC_sugar_binding_like; cd01536 755731009685 Periplasmic binding protein domain; Region: Peripla_BP_4; pfam13407 755731009686 ligand binding site [chemical binding]; other site 755731009687 Cytochrome c biogenesis protein [Posttranslational modification, protein turnover, chaperones]; Region: CcdA; COG0785 755731009688 Cytochrome C biogenesis protein transmembrane region; Region: DsbD; cl15788 755731009689 gluconate 5-dehydrogenase; Provisional; Region: PRK08213 755731009690 gluconate 5-dehydrogenase (Ga5DH)-like, classical (c) SDRs; Region: Ga5DH-like_SDR_c; cd05347 755731009691 NADP binding site [chemical binding]; other site 755731009692 homodimer interface [polypeptide binding]; other site 755731009693 active site 755731009694 Probable zinc-binding domain; Region: zf-trcl; pfam13451 755731009695 translation initiation factor IF-3; Reviewed; Region: infC; PRK00028 755731009696 Translation initiation factor IF-3, N-terminal domain; Region: IF3_N; pfam05198 755731009697 Translation initiation factor IF-3, C-terminal domain; Region: IF3_C; pfam00707 755731009698 Long-chain acyl-CoA synthetases (AMP-forming) [Lipid metabolism]; Region: FAA1; COG1022 755731009699 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 755731009700 Long-chain fatty acid CoA synthetases and Bubblegum-like very long-chain fatty acid CoA synthetases; Region: VL_LC_FACS_like; cd05907 755731009701 acyl-activating enzyme (AAE) consensus motif; other site 755731009702 putative AMP binding site [chemical binding]; other site 755731009703 putative active site [active] 755731009704 putative CoA binding site [chemical binding]; other site 755731009705 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 755731009706 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 755731009707 dimerization interface [polypeptide binding]; other site 755731009708 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 755731009709 dimer interface [polypeptide binding]; other site 755731009710 phosphorylation site [posttranslational modification] 755731009711 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 755731009712 ATP binding site [chemical binding]; other site 755731009713 Mg2+ binding site [ion binding]; other site 755731009714 G-X-G motif; other site 755731009715 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 755731009716 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 755731009717 active site 755731009718 phosphorylation site [posttranslational modification] 755731009719 intermolecular recognition site; other site 755731009720 dimerization interface [polypeptide binding]; other site 755731009721 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 755731009722 DNA binding site [nucleotide binding] 755731009723 S-layer homology domain; Region: SLH; pfam00395 755731009724 S-layer homology domain; Region: SLH; pfam00395 755731009725 Putative D-3-Phosphoglycerate Dehydrogenases, NAD-binding and catalytic domains; Region: PGDH_like_3; cd12174 755731009726 putative ligand binding site [chemical binding]; other site 755731009727 putative NAD binding site [chemical binding]; other site 755731009728 putative catalytic site [active] 755731009729 C-terminal ACT (regulatory) domain of D-3-Phosphoglycerate Dehydrogenase (3PGDH) found in fungi and bacteria; Region: ACT_3PGDH; cd04901 755731009730 L-serine binding site [chemical binding]; other site 755731009731 ACT domain interface; other site 755731009732 Phosphoserine aminotransferase (PSAT) family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major group in this CD corresponds to phosphoserine aminotransferase (PSAT). PSAT is active as...; Region: PSAT_like; cd00611 755731009733 homodimer interface [polypeptide binding]; other site 755731009734 substrate-cofactor binding pocket; other site 755731009735 pyridoxal 5'-phosphate binding site [chemical binding]; other site 755731009736 catalytic residue [active] 755731009737 probable extracellular repeat, HAF family; Region: HAF_rpt; TIGR02913 755731009738 probable extracellular repeat, HAF family; Region: HAF_rpt; TIGR02913 755731009739 probable extracellular repeat, HAF family; Region: HAF_rpt; TIGR02913 755731009740 probable extracellular repeat, HAF family; Region: HAF_rpt; TIGR02913 755731009741 Rubredoxin, Small Modular nonheme iron binding domain containing a [Fe(SCys)4] center, present in rubrerythrin and nigerythrin and detected either N- or C-terminal to such proteins as flavin reductase, NAD(P)H-nitrite reductase, and...; Region: rubredoxin_SM; cd00729 755731009742 Rubredoxin; Region: Rubredoxin; pfam00301 755731009743 iron binding site [ion binding]; other site 755731009744 Rubrerythrin [Energy production and conversion]; Region: COG1592 755731009745 rubrerythrin-like, diiron-binding domain; Region: Rubrerythrin_like; cd01046 755731009746 diiron binding motif [ion binding]; other site 755731009747 Copper amine oxidase N-terminal domain; Region: Cu_amine_oxidN1; pfam07833 755731009748 Predicted Co/Zn/Cd cation transporters [Inorganic ion transport and metabolism]; Region: MMT1; COG0053 755731009749 Cation efflux family; Region: Cation_efflux; cl00316 755731009750 Protein of unknown function (DUF445); Region: DUF445; pfam04286 755731009751 YihA (EngB) GTPase family; Region: YihA_EngB; cd01876 755731009752 G1 box; other site 755731009753 GTP/Mg2+ binding site [chemical binding]; other site 755731009754 Switch I region; other site 755731009755 G2 box; other site 755731009756 G3 box; other site 755731009757 Switch II region; other site 755731009758 G4 box; other site 755731009759 G5 box; other site 755731009760 Na+-driven multidrug efflux pump [Defense mechanisms]; Region: NorM; COG0534 755731009761 Uncharacterized subfamily of the multidrug and toxic compound extrusion (MATE) proteins; Region: MATE_like_8; cd13134 755731009762 Long-chain acyl-CoA synthetases (AMP-forming) [Lipid metabolism]; Region: FAA1; COG1022 755731009763 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 755731009764 Long-chain fatty acid CoA synthetases and Bubblegum-like very long-chain fatty acid CoA synthetases; Region: VL_LC_FACS_like; cd05907 755731009765 acyl-activating enzyme (AAE) consensus motif; other site 755731009766 acyl-activating enzyme (AAE) consensus motif; other site 755731009767 putative AMP binding site [chemical binding]; other site 755731009768 putative active site [active] 755731009769 putative CoA binding site [chemical binding]; other site 755731009770 Domain of unknown function (DU1801); Region: DUF1801; cl17490 755731009771 Dihydrofolate reductase [Coenzyme metabolism]; Region: FolA; COG0262 755731009772 Dihydrofolate reductase (DHFR). Reduces 7,8-dihydrofolate to 5,6,7,8-tetrahydrofolate with NADPH as a cofactor. This is an essential step in the biosynthesis of deoxythymidine phosphate since 5,6,7,8-tetrahydrofolate is required to regenerate 5; Region: DHFR; cl17426 755731009773 NADP+ binding site [chemical binding]; other site 755731009774 Protein of unknown function (DUF3237); Region: DUF3237; cl07905 755731009775 alpha/beta hydrolase fold; Region: Abhydrolase_3; pfam07859 755731009776 Prolyl oligopeptidase family; Region: Peptidase_S9; pfam00326 755731009777 NADH:flavin oxidoreductases, Old Yellow Enzyme family [Energy production and conversion]; Region: NemA; COG1902 755731009778 Enoate reductase (ER)-like FMN-binding domain. Enoate reductase catalyzes the NADH-dependent reduction of carbon-carbon double bonds of several molecules, including nonactivated 2-enoates, alpha,beta-unsaturated aldehydes, cyclic ketones, and...; Region: ER_like_FMN; cd02931 755731009779 putative active site [active] 755731009780 putative FMN binding site [chemical binding]; other site 755731009781 putative substrate binding site [chemical binding]; other site 755731009782 putative catalytic residue [active] 755731009783 putative 4Fe-4S cluster binding site [ion binding]; other site 755731009784 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox_2; pfam07992 755731009785 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500 755731009786 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 755731009787 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 755731009788 dimer interface [polypeptide binding]; other site 755731009789 putative CheW interface [polypeptide binding]; other site 755731009790 Alcohol dehydrogenase, class IV [Energy production and conversion]; Region: EutG; COG1454 755731009791 Iron-containing alcohol dehydrogenase; Region: Fe-ADH8; cd08186 755731009792 putative active site [active] 755731009793 metal binding site [ion binding]; metal-binding site 755731009794 Rubrerythrin [Energy production and conversion]; Region: COG1592 755731009795 Rubrerythrin, ferritin-like diiron-binding domain; Region: Rubrerythrin; cd01041 755731009796 binuclear metal center [ion binding]; other site 755731009797 Rubredoxin, Small Modular nonheme iron binding domain containing a [Fe(SCys)4] center, present in rubrerythrin and nigerythrin and detected either N- or C-terminal to such proteins as flavin reductase, NAD(P)H-nitrite reductase, and...; Region: rubredoxin_SM; cd00729 755731009798 iron binding site [ion binding]; other site 755731009799 Spermidine/putrescine-binding periplasmic protein [Amino acid transport and metabolism]; Region: PotD; COG0687 755731009800 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; cl17199 755731009801 ABC-type spermidine/putrescine transport system, permease component II [Amino acid transport and metabolism]; Region: PotC; COG1177 755731009802 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 755731009803 dimer interface [polypeptide binding]; other site 755731009804 conserved gate region; other site 755731009805 putative PBP binding loops; other site 755731009806 ABC-ATPase subunit interface; other site 755731009807 ABC-type Fe3+ transport system, permease component [Inorganic ion transport and metabolism]; Region: ThiP; COG1178 755731009808 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 755731009809 dimer interface [polypeptide binding]; other site 755731009810 conserved gate region; other site 755731009811 putative PBP binding loops; other site 755731009812 ABC-ATPase subunit interface; other site 755731009813 ABC-type spermidine/putrescine transport systems, ATPase components [Amino acid transport and metabolism]; Region: PotA; COG3842 755731009814 ATP-binding cassette domain of the polyamine transporter; Region: ABC_PotA_N; cd03300 755731009815 Walker A/P-loop; other site 755731009816 ATP binding site [chemical binding]; other site 755731009817 Q-loop/lid; other site 755731009818 ABC transporter signature motif; other site 755731009819 Walker B; other site 755731009820 D-loop; other site 755731009821 H-loop/switch region; other site 755731009822 TOBE domain; Region: TOBE_2; pfam08402 755731009823 DNA-binding transcriptional repressor PuuR; Provisional; Region: PRK09943 755731009824 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 755731009825 non-specific DNA binding site [nucleotide binding]; other site 755731009826 salt bridge; other site 755731009827 sequence-specific DNA binding site [nucleotide binding]; other site 755731009828 Cupin domain; Region: Cupin_2; pfam07883 755731009829 ABC-type polar amino acid transport system, ATPase component [Amino acid transport and metabolism]; Region: GlnQ; COG1126 755731009830 ATP-binding cassette domain of the histidine and glutamine transporters; Region: ABC_HisP_GlnQ; cd03262 755731009831 Walker A/P-loop; other site 755731009832 ATP binding site [chemical binding]; other site 755731009833 Q-loop/lid; other site 755731009834 ABC transporter signature motif; other site 755731009835 Walker B; other site 755731009836 D-loop; other site 755731009837 H-loop/switch region; other site 755731009838 ABC-type arginine transport system, permease component [Amino acid transport and metabolism]; Region: ArtQ; COG4215 755731009839 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 755731009840 dimer interface [polypeptide binding]; other site 755731009841 conserved gate region; other site 755731009842 putative PBP binding loops; other site 755731009843 ABC-ATPase subunit interface; other site 755731009844 Bacterial extracellular solute-binding proteins, family 3; Region: SBP_bac_3; pfam00497 755731009845 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 755731009846 substrate binding pocket [chemical binding]; other site 755731009847 membrane-bound complex binding site; other site 755731009848 hinge residues; other site 755731009849 Membrane proteins related to metalloendopeptidases [Cell envelope biogenesis, outer membrane]; Region: NlpD; COG0739 755731009850 Peptidase family M23; Region: Peptidase_M23; pfam01551 755731009851 Putative catalytic NodB homology domain of a hypothetical protein Ecf1 from Escherichia coli and similar proteins; Region: CE4_Ecf1_like_5s; cd10969 755731009852 putative active site [active] 755731009853 putative metal binding site [ion binding]; other site 755731009854 ABC-type nitrate/sulfonate/bicarbonate transport system, ATPase component [Inorganic ion transport and metabolism]; Region: TauB; COG1116 755731009855 ATP-binding cassette domain of the nitrate and sulfonate transporters; Region: ABC_NrtD_SsuB_transporters; cd03293 755731009856 Walker A/P-loop; other site 755731009857 ATP binding site [chemical binding]; other site 755731009858 Q-loop/lid; other site 755731009859 ABC transporter signature motif; other site 755731009860 Walker B; other site 755731009861 D-loop; other site 755731009862 H-loop/switch region; other site 755731009863 ABC-type nitrate/sulfonate/bicarbonate transport system, permease component [Inorganic ion transport and metabolism]; Region: TauC; COG0600 755731009864 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 755731009865 dimer interface [polypeptide binding]; other site 755731009866 conserved gate region; other site 755731009867 putative PBP binding loops; other site 755731009868 ABC-ATPase subunit interface; other site 755731009869 ABC-type nitrate/sulfonate/bicarbonate transport systems, periplasmic components [Inorganic ion transport and metabolism]; Region: TauA; COG0715 755731009870 NMT1-like family; Region: NMT1_2; pfam13379 755731009871 ABC-type metal ion transport system, periplasmic component/surface antigen [Inorganic ion transport and metabolism]; Region: NlpA; COG1464 755731009872 NLPA lipoprotein; Region: Lipoprotein_9; pfam03180 755731009873 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 755731009874 dimer interface [polypeptide binding]; other site 755731009875 conserved gate region; other site 755731009876 ABC-ATPase subunit interface; other site 755731009877 DL-methionine transporter ATP-binding subunit; Provisional; Region: metN; PRK11153 755731009878 ATP-binding cassette domain of methionine transporter; Region: ABC_MetN_methionine_transporter; cd03258 755731009879 Walker A/P-loop; other site 755731009880 ATP binding site [chemical binding]; other site 755731009881 Q-loop/lid; other site 755731009882 ABC transporter signature motif; other site 755731009883 Walker B; other site 755731009884 D-loop; other site 755731009885 H-loop/switch region; other site 755731009886 NIL domain; Region: NIL; pfam09383 755731009887 Predicted transcriptional regulator [Transcription]; Region: COG1959 755731009888 Transcriptional regulator; Region: Rrf2; cl17282 755731009889 ATP-utilizing enzymes of the PP-loop superfamily [General function prediction only]; Region: COG1606 755731009890 This is a subfamily of Adenine nucleotide alpha hydrolases superfamily. Adenine nucleotide alpha hydrolases superfamily includes N type ATP PPases and ATP sulphurylases. It forms a apha/beta/apha fold which binds to Adenosine group. This subfamily; Region: Alpha_ANH_like_I; cd01990 755731009891 Ligand Binding Site [chemical binding]; other site 755731009892 DNA topoisomerase III; Provisional; Region: PRK07726 755731009893 TOPRIM_TopoIA_TopoIII: The topoisomerase-primase (TORPIM) domain found in members of the type IA family of DNA topoisomerases (Topo IA) similar to topoisomerase III. Type IA DNA topoisomerases remove (relax) negative supercoils in the DNA by: cleaving...; Region: TOPRIM_TopoIA_TopoIII; cd03362 755731009894 active site 755731009895 putative interdomain interaction site [polypeptide binding]; other site 755731009896 putative metal-binding site [ion binding]; other site 755731009897 putative nucleotide binding site [chemical binding]; other site 755731009898 DNA Topoisomerase, subtype IA; DNA-binding, ATP-binding and catalytic domain of bacterial DNA topoisomerases I and III, and eukaryotic DNA topoisomerase III and eubacterial and archael reverse gyrases. Topoisomerases clevage single or double stranded DNA...; Region: TOP1Ac; cd00186 755731009899 domain I; other site 755731009900 DNA binding groove [nucleotide binding] 755731009901 phosphate binding site [ion binding]; other site 755731009902 domain II; other site 755731009903 domain III; other site 755731009904 nucleotide binding site [chemical binding]; other site 755731009905 catalytic site [active] 755731009906 domain IV; other site 755731009907 Zn-finger domain associated with topoisomerase type I [DNA replication, recombination, and repair]; Region: TopA; COG0551 755731009908 RNA polymerases M/15 Kd subunit; Region: RNA_POL_M_15KD; cl02717 755731009909 3-amino-5-hydroxybenoic acid synthesis related protein; Region: AHBA_synth_RP; TIGR01454 755731009910 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 755731009911 motif II; other site 755731009912 Transcriptional regulator/sugar kinase [Transcription / Carbohydrate transport and metabolism]; Region: NagC; COG1940 755731009913 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cd00012 755731009914 nucleotide binding site [chemical binding]; other site 755731009915 Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673 755731009916 Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408 755731009917 Oxidoreductase family, C-terminal alpha/beta domain; Region: GFO_IDH_MocA_C; pfam02894 755731009918 Acyl-CoA synthetases (AMP-forming)/AMP-acid ligases II [Lipid metabolism / Secondary metabolites biosynthesis, transport, and catabolism]; Region: CaiC; COG0318 755731009919 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 755731009920 acyl-activating enzyme (AAE) consensus motif; other site 755731009921 AMP binding site [chemical binding]; other site 755731009922 active site 755731009923 CoA binding site [chemical binding]; other site 755731009924 Peptidase family U32; Region: Peptidase_U32; pfam01136 755731009925 Uncharacterized conserved protein [Function unknown]; Region: COG2006 755731009926 Domain of unknown function (DUF362); Region: DUF362; pfam04015 755731009927 Ferredoxin [Energy production and conversion]; Region: NapF; COG1145 755731009928 4Fe-4S binding domain; Region: Fer4_6; pfam12837 755731009929 B12 binding domain (B12-BD). Most of the members bind different cobalamid derivates, like B12 (adenosylcobamide) or methylcobalamin or methyl-Co(III) 5-hydroxybenzimidazolylcobamide. This domain is found in several enzymes, such as glutamate mutase; Region: B12-binding_like; cl00293 755731009930 B12 binding site [chemical binding]; other site 755731009931 Elongator protein 3, MiaB family, Radical SAM; Region: Elp3; smart00729 755731009932 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cl15377 755731009933 FeS/SAM binding site; other site 755731009934 B12 binding domain (B12-BD). Most of the members bind different cobalamid derivates, like B12 (adenosylcobamide) or methylcobalamin or methyl-Co(III) 5-hydroxybenzimidazolylcobamide. This domain is found in several enzymes, such as glutamate mutase; Region: B12-binding_like; cl00293 755731009935 B12 binding site [chemical binding]; other site 755731009936 Elongator protein 3, MiaB family, Radical SAM; Region: Elp3; smart00729 755731009937 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 755731009938 FeS/SAM binding site; other site 755731009939 Predicted carbamoyl transferase, NodU family [Posttranslational modification, protein turnover, chaperones]; Region: COG2192 755731009940 Carbamoyltransferase; Region: CmcH_NodU; pfam02543 755731009941 B12 binding domain_like associated with radical SAM domain. This domain shows similarity with B12 (adenosylcobamide) binding domains found in several enzymes, such as glutamate mutase, methionine synthase and methylmalonyl-CoA mutase, but it lacks the...; Region: radical_SAM_B12_BD; cd02068 755731009942 Radical SAM superfamily; Region: Radical_SAM; pfam04055 755731009943 Peptidase family U32; Region: Peptidase_U32; pfam01136 755731009944 B12 binding domain_like associated with radical SAM domain. This domain shows similarity with B12 (adenosylcobamide) binding domains found in several enzymes, such as glutamate mutase, methionine synthase and methylmalonyl-CoA mutase, but it lacks the...; Region: radical_SAM_B12_BD; cd02068 755731009945 Radical SAM superfamily; Region: Radical_SAM; pfam04055 755731009946 B12 binding domain; Region: B12-binding; pfam02310 755731009947 B12 binding site [chemical binding]; other site 755731009948 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 755731009949 FeS/SAM binding site; other site 755731009950 ABC-type uncharacterized transport system, ATPase component [General function prediction only]; Region: COG4586 755731009951 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 755731009952 Walker A/P-loop; other site 755731009953 ATP binding site [chemical binding]; other site 755731009954 Q-loop/lid; other site 755731009955 ABC transporter signature motif; other site 755731009956 Walker B; other site 755731009957 D-loop; other site 755731009958 H-loop/switch region; other site 755731009959 ADP-heptose:LPS heptosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaF; COG0859 755731009960 Lipopolysaccharide heptosyltransferase is involved in the biosynthesis of lipooligosaccharide (LOS). Lipopolysaccharide (LPS) is a major component of the outer membrane of gram-negative bacteria. LPS heptosyltransferase transfers heptose molecules from...; Region: GT1_LPS_heptosyltransferase; cd03789 755731009961 putative active site [active] 755731009962 ADP-heptose:LPS heptosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaF; COG0859 755731009963 Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013 755731009964 Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013 755731009965 Predicted Fe-S oxidoreductases [General function prediction only]; Region: COG0535 755731009966 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 755731009967 FeS/SAM binding site; other site 755731009968 ABC-type uncharacterized transport system, permease component [General function prediction only]; Region: COG4587 755731009969 ABC-2 family transporter protein; Region: ABC2_membrane_6; cl01496 755731009970 ABC-type uncharacterized transport system, permease component [General function prediction only]; Region: COG4587 755731009971 ABC-2 family transporter protein; Region: ABC2_membrane_6; cl01496 755731009972 Phosphopantetheine attachment site; Region: PP-binding; cl09936 755731009973 GlcNAc-PI de-N-acetylase; Region: PIG-L; pfam02585 755731009974 Glycosyltransferases involved in cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WcaA; COG0463 755731009975 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394 755731009976 active site 755731009977 N-Utilization Substance G (NusG) N-terminal (NGN) domain Superfamily; Region: NGN; cd08000 755731009978 Transcription antiterminator [Transcription]; Region: NusG; COG0250 755731009979 NusG contains an NGN domain at its N-terminus and KOW motif at its C-terminus; Region: KOW_NusG; cd06091 755731009980 heterodimer interface [polypeptide binding]; other site 755731009981 homodimer interface [polypeptide binding]; other site 755731009982 Mannose-1-phosphate guanylyltransferase [Cell envelope biogenesis, outer membrane]; Region: {ManC}; COG0836 755731009983 GDP-M1P_Guanylyltransferase catalyzes the formation of GDP-Mannose; Region: GDP-M1P_Guanylyltransferase; cd02509 755731009984 Substrate binding site; other site 755731009985 Cupin domain; Region: Cupin_2; cl17218 755731009986 A predicted NlpC/p60-like peptidase; Region: BtrH; pfam14399 755731009987 Glycosyl hydrolase family 43, includes arabinoxylan arabinofuranohydrolase, beta-xylosidase, endo-1,4-beta-xylanase, alpha-L-arabinofuranosidase; Region: GH43_AXH_like; cd08990 755731009988 substrate binding site [chemical binding]; other site 755731009989 active site 755731009990 Carbohydrate Binding Module 6 (CBM6) and CBM35_like superfamily; Region: CBM6-CBM35-CBM36_like; cl14880 755731009991 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 755731009992 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 755731009993 Peptidase domain in the S8 and S53 families; Region: Peptidases_S8_S53; cl10459 755731009994 active site 755731009995 catalytic residues [active] 755731009996 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 755731009997 Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase; Region: HATPase_c; pfam02518 755731009998 ATP binding site [chemical binding]; other site 755731009999 Mg2+ binding site [ion binding]; other site 755731010000 G-X-G motif; other site 755731010001 ABC-type Na+ transport system, ATPase component [Energy production and conversion / Inorganic ion transport and metabolism]; Region: NatA; COG4555 755731010002 ATP-binding cassette domain of the drug resistance transporter and related proteins, subfamily A; Region: ABC_DR_subfamily_A; cd03230 755731010003 Walker A/P-loop; other site 755731010004 ATP binding site [chemical binding]; other site 755731010005 Q-loop/lid; other site 755731010006 ABC transporter signature motif; other site 755731010007 Walker B; other site 755731010008 D-loop; other site 755731010009 H-loop/switch region; other site 755731010010 type 2 lantibiotic biosynthesis protein LanM; Region: lanti_2_LanM; TIGR03897 755731010011 LanC-like proteins. LanC is the cyclase enzyme of the lanthionine synthetase. Lanthionine is a lantibiotic, a unique class of peptide antibiotics. They are ribosomally synthesized as a precursor peptide and then post-translationally modified to contain...; Region: LanC_like; cl04955 755731010012 active site 755731010013 zinc binding site [ion binding]; other site 755731010014 NADPH-dependent FMN reductase; Region: FMN_red; pfam03358 755731010015 Multimeric flavodoxin WrbA [General function prediction only]; Region: WrbA; COG0655 755731010016 Sugar kinases, ribokinase family [Carbohydrate transport and metabolism]; Region: RbsK; COG0524 755731010017 Fructokinases (FRKs) mainly from bacteria and plants are enzymes with high specificity for fructose, as are all FRKs, but they catalyzes the conversion of fructose to fructose-6-phosphate, which is an entry point into glycolysis via conversion into...; Region: bac_FRK; cd01167 755731010018 putative substrate binding site [chemical binding]; other site 755731010019 putative ATP binding site [chemical binding]; other site 755731010020 Medium chain reductase/dehydrogenase (MDR)/zinc-dependent alcohol dehydrogenase-like family; Region: MDR; cl16912 755731010021 Threonine dehydrogenase and related Zn-dependent dehydrogenases [Amino acid transport and metabolism / General function prediction only]; Region: Tdh; COG1063 755731010022 NAD(P) binding site [chemical binding]; other site 755731010023 Threonine dehydrogenase and related Zn-dependent dehydrogenases [Amino acid transport and metabolism / General function prediction only]; Region: Tdh; COG1063 755731010024 L-threonine dehydrogenase; Region: threonine_DH_like; cd08234 755731010025 putative NAD(P) binding site [chemical binding]; other site 755731010026 catalytic Zn binding site [ion binding]; other site 755731010027 Threonine dehydrogenase and related Zn-dependent dehydrogenases [Amino acid transport and metabolism / General function prediction only]; Region: Tdh; COG1063 755731010028 Alcohol dehydrogenases of the MDR family; Region: Zn_ADH2; cd08256 755731010029 putative NAD(P) binding site [chemical binding]; other site 755731010030 catalytic Zn binding site [ion binding]; other site 755731010031 structural Zn binding site [ion binding]; other site 755731010032 FAD dependent oxidoreductase; Region: FAD_oxidored; pfam12831 755731010033 Anaerobic glycerol-3-phosphate dehydrogenase [Amino acid transport and metabolism]; Region: GlpB; cl17730 755731010034 FAD dependent oxidoreductase; Region: FAD_oxidored; pfam12831 755731010035 FAD dependent oxidoreductase; Region: FAD_oxidored; pfam12831 755731010036 ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653 755731010037 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; pfam01547 755731010038 ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395 755731010039 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 755731010040 dimer interface [polypeptide binding]; other site 755731010041 conserved gate region; other site 755731010042 putative PBP binding loops; other site 755731010043 ABC-ATPase subunit interface; other site 755731010044 ABC-type polysaccharide transport system, permease component [Carbohydrate transport and metabolism]; Region: LplB; COG4209 755731010045 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 755731010046 dimer interface [polypeptide binding]; other site 755731010047 conserved gate region; other site 755731010048 putative PBP binding loops; other site 755731010049 ABC-ATPase subunit interface; other site 755731010050 Predicted signal transduction protein with a C-terminal ATPase domain [Signal transduction mechanisms]; Region: COG2972 755731010051 Histidine kinase; Region: His_kinase; pfam06580 755731010052 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 755731010053 ATP binding site [chemical binding]; other site 755731010054 Mg2+ binding site [ion binding]; other site 755731010055 G-X-G motif; other site 755731010056 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 755731010057 Response regulator receiver domain; Region: Response_reg; pfam00072 755731010058 active site 755731010059 phosphorylation site [posttranslational modification] 755731010060 intermolecular recognition site; other site 755731010061 dimerization interface [polypeptide binding]; other site 755731010062 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 755731010063 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 755731010064 FAD dependent oxidoreductase; Region: FAD_oxidored; pfam12831 755731010065 FAD dependent oxidoreductase; Region: FAD_oxidored; pfam12831 755731010066 Sugar phosphate isomerases/epimerases [Carbohydrate transport and metabolism]; Region: IolE; COG1082 755731010067 AP endonuclease family 2; These endonucleases play a role in DNA repair. Cleave phosphodiester bonds at apurinic or apyrimidinic sites; the alignment also contains hexulose-6-phosphate isomerases, enzymes that catalyze the epimerization of...; Region: AP2Ec; cl12060 755731010068 DNA interaction; other site 755731010069 Metal-binding active site; metal-binding site 755731010070 A predicted NlpC/p60-like peptidase; Region: BtrH; pfam14399 755731010071 Protein of unknown function (DUF4256); Region: DUF4256; pfam14066 755731010072 Uncharacterized conserved protein [Function unknown]; Region: COG4127 755731010073 Restriction endonuclease; Region: Mrr_cat; pfam04471 755731010074 Predicted transcriptional regulators [Transcription]; Region: COG1695 755731010075 Transcriptional regulator PadR-like family; Region: PadR; pfam03551 755731010076 Domain of unknown function (DUF4180); Region: DUF4180; pfam13788 755731010077 MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704 755731010078 FtsX-like permease family; Region: FtsX; pfam02687 755731010079 ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136 755731010080 ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255 755731010081 Walker A/P-loop; other site 755731010082 ATP binding site [chemical binding]; other site 755731010083 Q-loop/lid; other site 755731010084 ABC transporter signature motif; other site 755731010085 Walker B; other site 755731010086 D-loop; other site 755731010087 H-loop/switch region; other site 755731010088 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 755731010089 dimerization interface [polypeptide binding]; other site 755731010090 putative DNA binding site [nucleotide binding]; other site 755731010091 putative Zn2+ binding site [ion binding]; other site 755731010092 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 755731010093 Radical SAM superfamily; Region: Radical_SAM; pfam04055 755731010094 FeS/SAM binding site; other site 755731010095 Condensation domain; Region: Condensation; pfam00668 755731010096 Non-ribosomal peptide synthetase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: EntF; COG1020 755731010097 Nonribosomal peptide synthase; Region: NRPS; pfam08415 755731010098 The adenylation domain of nonribosomal peptide synthetases (NRPS), including Streptoalloteichus tallysomycin biosynthesis genes; Region: A_NRPS_TlmIV_like; cd12114 755731010099 acyl-activating enzyme (AAE) consensus motif; other site 755731010100 AMP binding site [chemical binding]; other site 755731010101 Phosphopantetheine attachment site; Region: PP-binding; pfam00550 755731010102 thioester reductase domain; Region: Thioester-redct; TIGR01746 755731010103 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 755731010104 NAD(P) binding site [chemical binding]; other site 755731010105 active site 755731010106 Acyl carrier protein [Lipid metabolism / Secondary metabolites biosynthesis, transport, and catabolism]; Region: AcpP; COG0236 755731010107 Long-chain acyl-CoA synthetases (AMP-forming) [Lipid metabolism]; Region: FAA1; COG1022 755731010108 Long-chain fatty acid CoA synthetases and Bubblegum-like very long-chain fatty acid CoA synthetases; Region: VL_LC_FACS_like; cd05907 755731010109 acyl-activating enzyme (AAE) consensus motif; other site 755731010110 putative AMP binding site [chemical binding]; other site 755731010111 putative active site [active] 755731010112 putative CoA binding site [chemical binding]; other site 755731010113 Predicted thioesterase involved in non-ribosomal peptide biosynthesis [Secondary metabolites biosynthesis, transport, and catabolism]; Region: GrsT; COG3208 755731010114 Protein of unknown function (DUF1706); Region: DUF1706; pfam08020 755731010115 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 755731010116 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 755731010117 dimer interface [polypeptide binding]; other site 755731010118 phosphorylation site [posttranslational modification] 755731010119 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 755731010120 ATP binding site [chemical binding]; other site 755731010121 Mg2+ binding site [ion binding]; other site 755731010122 G-X-G motif; other site 755731010123 ABC-2 family transporter protein; Region: ABC2_membrane_2; cl17866 755731010124 ABC-2 family transporter protein; Region: ABC2_membrane_4; pfam12730 755731010125 ABC-type multidrug transport system, ATPase component [Defense mechanisms]; Region: CcmA; COG1131 755731010126 ATP-binding cassette domain of the bacitracin-resistance transporter; Region: ABC_BcrA_bacitracin_resist; cd03268 755731010127 Walker A/P-loop; other site 755731010128 ATP binding site [chemical binding]; other site 755731010129 Q-loop/lid; other site 755731010130 ABC transporter signature motif; other site 755731010131 Walker B; other site 755731010132 D-loop; other site 755731010133 H-loop/switch region; other site 755731010134 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 755731010135 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 755731010136 active site 755731010137 phosphorylation site [posttranslational modification] 755731010138 intermolecular recognition site; other site 755731010139 dimerization interface [polypeptide binding]; other site 755731010140 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 755731010141 DNA binding site [nucleotide binding] 755731010142 Glycosyl hydrolase family 10; Region: Glyco_hydro_10; pfam00331 755731010143 Dockerin type I repeat; Region: Dockerin_1; pfam00404 755731010144 Dockerin type I repeat; Region: Dockerin_1; pfam00404 755731010145 Transcriptional regulators [Transcription]; Region: PhnF; COG2188 755731010146 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 755731010147 DNA-binding site [nucleotide binding]; DNA binding site 755731010148 UTRA domain; Region: UTRA; pfam07702 755731010149 Predicted phosphosugar isomerases [Cell envelope biogenesis, outer membrane]; Region: AgaS; COG2222 755731010150 SIS (Sugar ISomerase) domain repeat 1 found in Glucosamine 6-phosphate synthase (GlmS) and Glucosamine-6-phosphate deaminase (GlmD). The SIS domain is found in many phosphosugar isomerases and phosphosugar binding proteins. GlmS contains a N-terminal...; Region: SIS_GlmS_GlmD_1; cd05008 755731010151 dimer interface [polypeptide binding]; other site 755731010152 active site 755731010153 SIS (Sugar ISomerase) domain repeat 2 found in Glucosamine 6-phosphate synthase (GlmS) and Glucosamine-6-phosphate deaminase (GlmD). The SIS domain is found in many phosphosugar isomerases and phosphosugar binding proteins. GlmS contains a N-terminal...; Region: SIS_GlmS_GlmD_2; cd05009 755731010154 dimer interface [polypeptide binding]; other site 755731010155 active site 755731010156 GlcNAc-PI de-N-acetylase; Region: PIG-L; pfam02585 755731010157 Bacterial Ig-like domain (group 2); Region: Big_2; pfam02368 755731010158 Bacterial surface proteins containing Ig-like domains [Cell motility and secretion]; Region: COG5492 755731010159 S-layer homology domain; Region: SLH; pfam00395 755731010160 S-layer homology domain; Region: SLH; pfam00395 755731010161 S-layer homology domain; Region: SLH; pfam00395 755731010162 hypothetical protein; Provisional; Region: PRK02947 755731010163 RpiR-like protein. RpiR contains a SIS (Sugar ISomerase) domain, which is found in many phosphosugar isomerases and phosphosugar binding proteins. In E. coli, rpiR negatively regulates the expression of rpiB gene. Both rpiB and rpiA are ribose phosphate...; Region: SIS_RpiR; cd05013 755731010164 putative active site [active] 755731010165 UDP-N-acetylglucosamine diphosphorylase/glucosamine-1-phosphate N-acetyltransferase; Region: Arch_glmU; TIGR03992 755731010166 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394 755731010167 active site 755731010168 Left-handed parallel beta-Helix (LbetaH or LbH) domain: The alignment contains 5 turns, each containing three imperfect tandem repeats of a hexapeptide repeat motif (X-[STAV]-X-[LIV]-[GAED]-X). Proteins containing hexapeptide repeats are often enzymes...; Region: LbetaH; cl00160 755731010169 putative trimer interface [polypeptide binding]; other site 755731010170 putative CoA binding site [chemical binding]; other site 755731010171 Uncharacterized conserved protein [Function unknown]; Region: COG3589 755731010172 Bacterial protein of unknown function (DUF871); Region: DUF871; pfam05913 755731010173 Alpha-galactosidases/6-phospho-beta-glucosidases, family 4 of glycosyl hydrolases [Carbohydrate transport and metabolism]; Region: CelF; COG1486 755731010174 Glycoside Hydrolases Family 4; Phospho-beta-glucosidase; Region: GH4_P_beta_glucosidase; cd05296 755731010175 NAD binding site [chemical binding]; other site 755731010176 sugar binding site [chemical binding]; other site 755731010177 divalent metal binding site [ion binding]; other site 755731010178 tetramer (dimer of dimers) interface [polypeptide binding]; other site 755731010179 dimer interface [polypeptide binding]; other site 755731010180 Predicted N-acetylglucosamine kinase [Carbohydrate transport and metabolism]; Region: COG2971 755731010181 RDD family; Region: RDD; pfam06271 755731010182 Phosphotransferase system cellobiose-specific component IIC [Carbohydrate transport and metabolism]; Region: CelB; COG1455 755731010183 cellobiose phosphotransferase system IIC component; Reviewed; Region: celD; PRK09592 755731010184 PTS_IIB_chitobiose_lichenan: subunit IIB of enzyme II (EII) of the N,N-diacetylchitobiose-specific and lichenan-specific phosphoenolpyruvate:carbohydrate phosphotransferase system (PTS). In these systems, EII is either a lichenan- or an N; Region: PTS_IIB_chitobiose_lichenan; cd05564 755731010185 active site 755731010186 P-loop; other site 755731010187 phosphorylation site [posttranslational modification] 755731010188 PTS_IIA, PTS system, lactose/cellobiose specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_lac; cd00215 755731010189 methionine cluster; other site 755731010190 active site 755731010191 phosphorylation site [posttranslational modification] 755731010192 metal binding site [ion binding]; metal-binding site 755731010193 Histidine-containing phosphocarrier protein (HPr)-like proteins. HPr is a central component of the bacterial phosphoenolpyruvate sugar phosphotransferase system (PTS). The PTS catalyses the phosphorylation of sugar substrates during their translocation...; Region: PTS-HPr_like; cd00367 755731010194 dimerization domain swap beta strand [polypeptide binding]; other site 755731010195 regulatory protein interface [polypeptide binding]; other site 755731010196 active site 755731010197 regulatory phosphorylation site [posttranslational modification]; other site 755731010198 PEP-utilising enzyme, N-terminal; Region: PEP-utilisers_N; pfam05524 755731010199 Phosphoenolpyruvate-protein kinase (PTS system EI component in bacteria) [Carbohydrate transport and metabolism]; Region: PtsA; COG1080 755731010200 PEP-utilising enzyme, mobile domain; Region: PEP-utilizers; pfam00391 755731010201 PEP-utilising enzyme, TIM barrel domain; Region: PEP-utilizers_C; pfam02896 755731010202 Transcriptional antiterminator [Transcription]; Region: BglG; COG3711 755731010203 HTH domain; Region: HTH_11; pfam08279 755731010204 Mga helix-turn-helix domain; Region: Mga; pfam05043 755731010205 PRD domain; Region: PRD; pfam00874 755731010206 PTS_IIB_bgl_like: the PTS (phosphotransferase system) IIB domain of a family of sensory systems composed of a membrane-bound sugar-sensor (similar to BglF) and a transcription antiterminator (similar to BglG) which regulate expression of genes involved...; Region: PTS_IIB_bgl_like; cd05568 755731010207 active site 755731010208 P-loop; other site 755731010209 phosphorylation site [posttranslational modification] 755731010210 Predicted RNA-bindining protein (contains S1 and HTH domains) [General function prediction only]; Region: COG2996 755731010211 S1 domain; Region: S1_2; pfam13509 755731010212 S1 domain; Region: S1_2; pfam13509 755731010213 Ribosomal protein S1-like RNA-binding domain; Region: S1; smart00316 755731010214 RNA binding site [nucleotide binding]; other site 755731010215 Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673 755731010216 Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408 755731010217 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 755731010218 putative substrate translocation pore; other site 755731010219 Glycosyltransferases, probably involved in cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: COG1215 755731010220 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cd00761 755731010221 active site 755731010222 Predicted phosphatases [General function prediction only]; Region: Gph; COG0546 755731010223 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 755731010224 motif II; other site 755731010225 6-phosphogluconolactonase/Glucosamine-6-phosphate isomerase/deaminase [Carbohydrate transport and metabolism]; Region: NagB; COG0363 755731010226 GlcN6P_deaminase: Glucosamine-6-phosphate (GlcN6P) deaminase subfamily; GlcN6P deaminase catalyzes the reversible conversion of GlcN6P to D-fructose-6-phosphate (Fru6P) and ammonium. The reaction is an aldo-keto isomerization coupled with an amination or...; Region: GlcN6P_deaminase; cd01399 755731010227 active site 755731010228 trimer interface [polypeptide binding]; other site 755731010229 allosteric site; other site 755731010230 active site lid [active] 755731010231 hexamer (dimer of trimers) interface [polypeptide binding]; other site 755731010232 Dehydroquinate synthase (DHQS) catalyzes the conversion of DAHP to DHQ in shikimate pathway for aromatic compounds synthesis; Region: DHQS; cd08195 755731010233 active site 755731010234 dimer interface [polypeptide binding]; other site 755731010235 metal binding site [ion binding]; metal-binding site 755731010236 DegT/DnrJ/EryC1/StrS aminotransferase family; Region: DegT_DnrJ_EryC1; pfam01041 755731010237 3-amino-5-hydroxybenzoic acid synthase family (AHBA_syn). AHBA_syn family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The members of this CD are involved in various biosynthetic pathways for secondary...; Region: AHBA_syn; cd00616 755731010238 inhibitor-cofactor binding pocket; inhibition site 755731010239 pyridoxal 5'-phosphate binding site [chemical binding]; other site 755731010240 catalytic residue [active] 755731010241 DegT/DnrJ/EryC1/StrS aminotransferase family; Region: DegT_DnrJ_EryC1; pfam01041 755731010242 3-amino-5-hydroxybenzoic acid synthase family (AHBA_syn). AHBA_syn family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The members of this CD are involved in various biosynthetic pathways for secondary...; Region: AHBA_syn; cd00616 755731010243 inhibitor-cofactor binding pocket; inhibition site 755731010244 pyridoxal 5'-phosphate binding site [chemical binding]; other site 755731010245 catalytic residue [active] 755731010246 Uncharacterized protein conserved in bacteria (DUF2200); Region: DUF2200; pfam09966 755731010247 Uncharacterized ACR, YkgG family COG1556; Region: DUF162; pfam02589 755731010248 Golgi phosphoprotein 3 (GPP34); Region: GPP34; pfam05719 755731010249 Helix-Turn-Helix DNA binding domain of transcription regulators from the MerR superfamily; Region: HTH_MerR-SF; cl02600 755731010250 MerR HTH family regulatory protein; Region: MerR_1; pfam13411 755731010251 DNA binding residues [nucleotide binding] 755731010252 Uncharacterized protein related to plant photosystem II stability/assembly factor [General function prediction only]; Region: COG4447 755731010253 Uncharacterized protein related to plant photosystem II stability/assembly factor [General function prediction only]; Region: COG4447 755731010254 Glycosyl hydrolases family 11; Region: Glyco_hydro_11; pfam00457 755731010255 Carbohydrate Binding Module 6 (CBM6); many are appended to glycoside hydrolase (GH) family 11 and GH43 xylanase domains; Region: CBM6_xylanase-like; cd04084 755731010256 ligand binding site [chemical binding]; other site 755731010257 Catalytic NodB homology domain of the carbohydrate esterase 4 superfamily; Region: CE4_SF; cl15692 755731010258 Predicted xylanase/chitin deacetylase [Carbohydrate transport and metabolism]; Region: CDA1; COG0726 755731010259 Glycosyl hydrolases family 11; Region: Glyco_hydro_11; pfam00457 755731010260 Carbohydrate Binding Module 6 (CBM6); many are appended to glycoside hydrolase (GH) family 11 and GH43 xylanase domains; Region: CBM6_xylanase-like; cd04084 755731010261 ligand binding site [chemical binding]; other site 755731010262 Predicted Fe-S oxidoreductases [General function prediction only]; Region: COG0535 755731010263 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 755731010264 FeS/SAM binding site; other site 755731010265 radical SAM additional 4Fe4S-binding SPASM domain; Region: rSAM_more_4Fe4S; TIGR04085 755731010266 nif11-like peptide radical SAM maturase; Region: rSAM_nif11; TIGR04064 755731010267 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 755731010268 FeS/SAM binding site; other site 755731010269 radical SAM additional 4Fe4S-binding SPASM domain; Region: rSAM_more_4Fe4S; TIGR04085 755731010270 Bacillus haemolytic enterotoxin (HBL); Region: Bacillus_HBL; pfam05791 755731010271 AAA domain; Region: AAA_13; pfam13166 755731010272 nylC-like family; composed of proteins with similarity to Flavobacterium endo-type 6-aminohexanoate-oligomer hydrolase (EIII), the product of the nylon oligomer degradation gene, nylC. EIII is an amide hydrolase that catalyzes the degradation of...; Region: nylC_like; cd02252 755731010273 putative active site pocket [active] 755731010274 cleavage site 755731010275 Predicted transcriptional regulators [Transcription]; Region: SoxR; COG0789 755731010276 Helix-Turn-Helix DNA binding domain of MerR-like transcription regulators; Region: HTH_MerR-like; cd00592 755731010277 DNA binding residues [nucleotide binding] 755731010278 dimer interface [polypeptide binding]; other site 755731010279 Bacterial transcription activator, effector binding domain; Region: AraC_E_bind; smart00871 755731010280 Protein of unknown function (DUF3788); Region: DUF3788; pfam12663 755731010281 Response regulator containing CheY-like receiver and SARP domains [Signal transduction mechanisms]; Region: COG3947 755731010282 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 755731010283 active site 755731010284 phosphorylation site [posttranslational modification] 755731010285 intermolecular recognition site; other site 755731010286 dimerization interface [polypeptide binding]; other site 755731010287 Transcriptional regulatory protein, C terminal; Region: Trans_reg_C; smart00862 755731010288 Glycosyl hydrolases family 2, sugar binding domain; Region: Glyco_hydro_2_N; pfam02837 755731010289 7TM diverse intracellular signalling; Region: 7TMR-DISM_7TM; pfam07695 755731010290 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: COG4585 755731010291 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 755731010292 dimer interface [polypeptide binding]; other site 755731010293 phosphorylation site [posttranslational modification] 755731010294 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 755731010295 ATP binding site [chemical binding]; other site 755731010296 Mg2+ binding site [ion binding]; other site 755731010297 G-X-G motif; other site 755731010298 Response regulator receiver domain; Region: Response_reg; pfam00072 755731010299 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 755731010300 active site 755731010301 phosphorylation site [posttranslational modification] 755731010302 intermolecular recognition site; other site 755731010303 dimerization interface [polypeptide binding]; other site 755731010304 Histidine kinase; Region: His_kinase; pfam06580 755731010305 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 755731010306 ATP binding site [chemical binding]; other site 755731010307 Mg2+ binding site [ion binding]; other site 755731010308 G-X-G motif; other site 755731010309 S-layer homology domain; Region: SLH; pfam00395 755731010310 S-layer homology domain; Region: SLH; pfam00395 755731010311 S-layer homology domain; Region: SLH; pfam00395 755731010312 Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain [Posttranslational modification, protein turnover, chaperones]; Region: DegQ; COG0265 755731010313 Trypsin-like peptidase domain; Region: Trypsin_2; pfam13365 755731010314 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 755731010315 Prolyl oligopeptidase family; Region: Peptidase_S9; pfam00326 755731010316 MutT homolog-1 (MTH1) is a member of the Nudix hydrolase superfamily. MTH1, the mammalian counterpart of MutT, hydrolyzes oxidized purine nucleoside triphosphates, such as 8-oxo-dGTP and 2-hydroxy-ATP, to monophosphates, thereby preventing the...; Region: MTH1; cd03427 755731010317 putative active site [active] 755731010318 nucleotide binding site [chemical binding]; other site 755731010319 nudix motif; other site 755731010320 putative metal binding site [ion binding]; other site 755731010321 Predicted phosphatases [General function prediction only]; Region: Gph; COG0546 755731010322 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 755731010323 motif II; other site 755731010324 aromatic acid decarboxylase; Validated; Region: PRK05920 755731010325 Flavoprotein; Region: Flavoprotein; pfam02441 755731010326 3-octaprenyl-4-hydroxybenzoate carboxy-lyase; Region: UbiD; cl00311 755731010327 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 755731010328 active site 755731010329 putative GTP cyclohydrolase; Provisional; Region: PRK13674 755731010330 putative 7-cyano-7-deazaguanosine (preQ0) biosynthesis protein QueE, clostridial; Region: rSAM_QueE_Clost; TIGR03963 755731010331 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 755731010332 FeS/SAM binding site; other site 755731010333 6-pyruvoyl tetrahydropterin synthase; Region: PTPS; pfam01242 755731010334 Protein of unknown function, DUF606; Region: DUF606; pfam04657 755731010335 DOMON-like type 9 carbohydrate binding module of xylanases; Region: CBM9_like_1; cd00005 755731010336 Ca binding site [ion binding]; other site 755731010337 carbohydrate binding site [chemical binding]; other site 755731010338 Putative esterase; Region: Esterase; pfam00756 755731010339 Cupin domain; Region: Cupin_2; cl17218 755731010340 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 755731010341 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 755731010342 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 755731010343 Glycosyl hydrolase family 10; Region: Glyco_hydro_10; cl01495 755731010344 Cadherin-like beta sandwich domain; Region: Cadherin-like; pfam12733 755731010345 S-layer homology domain; Region: SLH; pfam00395 755731010346 S-layer homology domain; Region: SLH; pfam00395 755731010347 S-layer homology domain; Region: SLH; pfam00395 755731010348 peptide maturation system acyl carrier-related protein; Region: ocin_ACP_rel; TIGR04069 755731010349 peptide maturation system protein, TIGR04066 family; Region: nat_prod_clost 755731010350 Cys-rich peptide radical SAM maturase CcpM; Region: rSAM_ocin_clost; TIGR04068 755731010351 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 755731010352 FeS/SAM binding site; other site 755731010353 radical SAM additional 4Fe4S-binding SPASM domain; Region: rSAM_more_4Fe4S; TIGR04085 755731010354 putative bacteriocin precursor, CLI_3235 family; Region: ocin_CLI_3235; TIGR04065 755731010355 Erythromycin esterase; Region: Erythro_esteras; cl17110 755731010356 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 755731010357 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 755731010358 non-specific DNA binding site [nucleotide binding]; other site 755731010359 salt bridge; other site 755731010360 sequence-specific DNA binding site [nucleotide binding]; other site 755731010361 ABC-type cobalt transport system, ATPase component [Inorganic ion transport and metabolism]; Region: CbiO; COG1122 755731010362 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 755731010363 Walker A/P-loop; other site 755731010364 ATP binding site [chemical binding]; other site 755731010365 Q-loop/lid; other site 755731010366 ABC transporter signature motif; other site 755731010367 Walker B; other site 755731010368 D-loop; other site 755731010369 H-loop/switch region; other site 755731010370 Zinc metalloprotease (elastase) [Amino acid transport and metabolism]; Region: LasB; COG3227 755731010371 Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all...; Region: FN3; cd00063 755731010372 Interdomain contacts; other site 755731010373 Cytokine receptor motif; other site 755731010374 Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all...; Region: FN3; cd00063 755731010375 Interdomain contacts; other site 755731010376 Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all...; Region: FN3; cd00063 755731010377 Interdomain contacts; other site 755731010378 Cytokine receptor motif; other site 755731010379 Periplasmic copper-binding protein (NosD); Region: NosD; pfam05048 755731010380 Right handed beta helix region; Region: Beta_helix; pfam13229 755731010381 Right handed beta helix region; Region: Beta_helix; pfam13229 755731010382 Rhs family protein [Cell envelope biogenesis, outer membrane]; Region: RhsA; COG3209 755731010383 Rhs family protein [Cell envelope biogenesis, outer membrane]; Region: RhsA; COG3209 755731010384 YD repeat (two copies); Region: YD_repeat_2x; TIGR01643 755731010385 RHS Repeat; Region: RHS_repeat; pfam05593 755731010386 Rhs family protein [Cell envelope biogenesis, outer membrane]; Region: RhsA; COG3209 755731010387 RHS Repeat; Region: RHS_repeat; pfam05593 755731010388 RHS Repeat; Region: RHS_repeat; pfam05593 755731010389 RHS Repeat; Region: RHS_repeat; pfam05593 755731010390 RHS Repeat; Region: RHS_repeat; pfam05593 755731010391 RHS Repeat; Region: RHS_repeat; pfam05593 755731010392 RHS repeat-associated core domain; Region: Rhs_assc_core; TIGR03696 755731010393 Domain of unknown function (DUF955); Region: DUF955; pfam06114 755731010394 Uncharacterized conserved protein [Function unknown]; Region: COG4127 755731010395 Restriction endonuclease; Region: Mrr_cat; pfam04471 755731010396 Type I restriction enzyme R protein N terminus (HSDR_N); Region: HSDR_N; cl14958 755731010397 Type I site-specific restriction-modification system, R (restriction) subunit and related helicases [Defense mechanisms]; Region: COG0610 755731010398 Type I restriction modification DNA specificity domain; Region: Methylase_S; pfam01420 755731010399 Restriction endonuclease S subunits [Defense mechanisms]; Region: HsdS; COG0732 755731010400 Very Short Patch Repair (Vsr) Endonuclease. Endonucleases in DNA repair that recognize damaged DNA and cleave the phosphodiester backbone. Vsr endonucleases have a common endonuclease topology that has been tailored for recognition of TG mismatches; Region: Vsr; cd00221 755731010401 additional DNA contacts [nucleotide binding]; other site 755731010402 mismatch recognition site; other site 755731010403 active site 755731010404 zinc binding site [ion binding]; other site 755731010405 DNA intercalation site [nucleotide binding]; other site 755731010406 FOG: CheY-like receiver [Signal transduction mechanisms]; Region: CheY; COG0784 755731010407 Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase; Region: HATPase_c_3; pfam13589 755731010408 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 755731010409 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 755731010410 ATP binding site [chemical binding]; other site 755731010411 Mg2+ binding site [ion binding]; other site 755731010412 G-X-G motif; other site 755731010413 Site-specific DNA methylase [DNA replication, recombination, and repair]; Region: Dcm; COG0270 755731010414 Cytosine-C5 specific DNA methylases; Methyl transfer reactions play an important role in many aspects of biology. Cytosine-specific DNA methylases are found both in prokaryotes and eukaryotes. DNA methylation, or the covalent addition of a methyl group...; Region: Cyt_C5_DNA_methylase; cd00315 755731010415 cofactor binding site; other site 755731010416 DNA binding site [nucleotide binding] 755731010417 substrate interaction site [chemical binding]; other site 755731010418 Cytosine-C5 specific DNA methylases; Methyl transfer reactions play an important role in many aspects of biology. Cytosine-specific DNA methylases are found both in prokaryotes and eukaryotes. DNA methylation, or the covalent addition of a methyl group...; Region: Cyt_C5_DNA_methylase; cd00315 755731010419 Helix-turn-helix domain; Region: HTH_39; pfam14090 755731010420 HNH nucleases; HNH endonuclease signature which is found in viral, prokaryotic, and eukaryotic proteins. The alignment includes members of the large group of homing endonucleases, yeast intron 1 protein, MutS, as well as bacterial colicins, pyocins, and...; Region: HNHc; cd00085 755731010421 active site 755731010422 Cytosine-C5 specific DNA methylases; Methyl transfer reactions play an important role in many aspects of biology. Cytosine-specific DNA methylases are found both in prokaryotes and eukaryotes. DNA methylation, or the covalent addition of a methyl group...; Region: Cyt_C5_DNA_methylase; cd00315 755731010423 C-5 cytosine-specific DNA methylase; Region: DNA_methylase; pfam00145 755731010424 cofactor binding site; other site 755731010425 DNA binding site [nucleotide binding] 755731010426 substrate interaction site [chemical binding]; other site 755731010427 Helix-turn-helix domain; Region: HTH_17; pfam12728 755731010428 arsenical pump-driving ATPase; Region: arsen_driv_ArsA; TIGR04291 755731010429 ArsA ATPase functionas as an efflux pump located on the inner membrane of the cell. This ATP-driven oxyanion pump catalyzes the extrusion of arsenite, antimonite and arsenate. Maintenance of a low intracellular concentration of oxyanion produces...; Region: ArsA; cd02035 755731010430 P loop; other site 755731010431 Nucleotide binding site [chemical binding]; other site 755731010432 DTAP/Switch II; other site 755731010433 Switch I; other site 755731010434 ArsA ATPase functionas as an efflux pump located on the inner membrane of the cell. This ATP-driven oxyanion pump catalyzes the extrusion of arsenite, antimonite and arsenate. Maintenance of a low intracellular concentration of oxyanion produces...; Region: ArsA; cd02035 755731010435 P loop; other site 755731010436 Nucleotide binding site [chemical binding]; other site 755731010437 DTAP/Switch II; other site 755731010438 Switch I; other site 755731010439 Arsenical resistance operon trans-acting repressor ArsD; Region: ArsD; pfam06953 755731010440 Arsenite efflux pump ACR3 and related permeases [Inorganic ion transport and metabolism]; Region: ACR3; COG0798 755731010441 arsenical-resistance protein; Region: acr3; TIGR00832 755731010442 CoA-disulfide reductase; Region: CoA_CoA_reduc; TIGR03385 755731010443 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500 755731010444 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 755731010445 Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain; Region: Pyr_redox_dim; pfam02852 755731010446 Rhodanese Homology Domain (RHOD); an alpha beta fold domain found duplicated in the rhodanese protein. The cysteine containing enzymatically active version of the domain is also found in the Cdc25 class of protein phosphatases and a variety of proteins...; Region: RHOD; cl00125 755731010447 active site residue [active] 755731010448 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 755731010449 dimerization interface [polypeptide binding]; other site 755731010450 putative DNA binding site [nucleotide binding]; other site 755731010451 putative Zn2+ binding site [ion binding]; other site 755731010452 Sortase and related acyltransferases [Cell envelope biogenesis, outer membrane]; Region: COG1247 755731010453 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 755731010454 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl17182 755731010455 Coenzyme A binding pocket [chemical binding]; other site 755731010456 Putative redox-active protein (C_GCAxxG_C_C); Region: C_GCAxxG_C_C; pfam09719 755731010457 Methyltransferase domain; Region: Methyltransf_31; pfam13847 755731010458 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 755731010459 S-adenosylmethionine binding site [chemical binding]; other site 755731010460 MarR family; Region: MarR_2; pfam12802 755731010461 Transcriptional regulators [Transcription]; Region: MarR; COG1846 755731010462 Site-specific recombinases, DNA invertase Pin homologs [DNA replication, recombination, and repair]; Region: PinR; COG1961 755731010463 Serine Recombinase family, catalytic domain; a DNA binding domain may be present either N- or C-terminal to the catalytic domain. These enzymes perform site-specific recombination of DNA molecules by a concerted, four-strand cleavage and rejoining...; Region: Ser_Recombinase; cd00338 755731010464 catalytic residues [active] 755731010465 catalytic nucleophile [active] 755731010466 Recombinase; Region: Recombinase; pfam07508 755731010467 Recombinase zinc beta ribbon domain; Region: Zn_ribbon_recom; pfam13408 755731010468 Recombinase; Region: Recombinase; pfam07508 755731010469 Recombinase zinc beta ribbon domain; Region: Zn_ribbon_recom; pfam13408 755731010470 Site-specific recombinases, DNA invertase Pin homologs [DNA replication, recombination, and repair]; Region: PinR; COG1961 755731010471 Serine Recombinase family, catalytic domain; a DNA binding domain may be present either N- or C-terminal to the catalytic domain. These enzymes perform site-specific recombination of DNA molecules by a concerted, four-strand cleavage and rejoining...; Region: Ser_Recombinase; cd00338 755731010472 catalytic residues [active] 755731010473 catalytic nucleophile [active] 755731010474 Recombinase; Region: Recombinase; pfam07508 755731010475 Recombinase zinc beta ribbon domain; Region: Zn_ribbon_recom; pfam13408 755731010476 CRISPR/Cas system-associated protein Csx1; Region: Csx1_III-U; cl14784 755731010477 Site-specific recombinases, DNA invertase Pin homologs [DNA replication, recombination, and repair]; Region: PinR; COG1961 755731010478 Serine Recombinase family, catalytic domain; a DNA binding domain may be present either N- or C-terminal to the catalytic domain. These enzymes perform site-specific recombination of DNA molecules by a concerted, four-strand cleavage and rejoining...; Region: Ser_Recombinase; cd00338 755731010479 catalytic residues [active] 755731010480 catalytic nucleophile [active] 755731010481 RNA polymerase sigma factor, sigma-70 family; Region: sigma70-ECF; TIGR02937 755731010482 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cl17257 755731010483 DNA binding residues [nucleotide binding] 755731010484 GEMM cis-regulatory element; IMG reference gene:2509530200 755731010485 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 755731010486 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 755731010487 non-specific DNA binding site [nucleotide binding]; other site 755731010488 salt bridge; other site 755731010489 sequence-specific DNA binding site [nucleotide binding]; other site 755731010490 Domain of unknown function (DUF955); Region: DUF955; pfam06114 755731010491 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 755731010492 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 755731010493 non-specific DNA binding site [nucleotide binding]; other site 755731010494 salt bridge; other site 755731010495 sequence-specific DNA binding site [nucleotide binding]; other site 755731010496 Helix-turn-helix domain; Region: HTH_36; pfam13730 755731010497 Type IV secretory system Conjugative DNA transfer; Region: T4SS-DNA_transf; pfam02534 755731010498 TraM recognition site of TraD and TraG; Region: TraG-D_C; pfam12696 755731010499 CHC2 zinc finger; Region: zf-CHC2; cl17510 755731010500 Protein of unknown function (DUF3991); Region: DUF3991; pfam13154 755731010501 Toprim-like; Region: Toprim_2; pfam13155 755731010502 FOG: TPR repeat, SEL1 subfamily [General function prediction only]; Region: COG0790 755731010503 Sel1-like repeats; Region: SEL1; smart00671 755731010504 Sel1-like repeats; Region: SEL1; smart00671 755731010505 FOG: TPR repeat, SEL1 subfamily [General function prediction only]; Region: COG0790 755731010506 Sel1-like repeats; Region: SEL1; smart00671 755731010507 Sel1-like repeats; Region: SEL1; smart00671 755731010508 Sel1-like repeats; Region: SEL1; smart00671 755731010509 Sel1-like repeats; Region: SEL1; smart00671 755731010510 Sel1-like repeats; Region: SEL1; smart00671 755731010511 The hotdog fold was initially identified in the E. coli FabA (beta-hydroxydecanoyl-acyl carrier protein (ACP)-dehydratase) structure and subsequently in 4HBT (4-hydroxybenzoyl-CoA thioesterase) from Pseudomonas. A number of other seemingly unrelated...; Region: hot_dog; cl00509 755731010512 valyl-tRNA synthetase-like protein; Provisional; Region: PTZ00419 755731010513 GGCT-like domains, also called AIG2-like family. Gamma-glutamyl cyclotransferase (GGCT) catalyzes the formation of pyroglutamic acid (5-oxoproline) from dipeptides containing gamma-glutamyl, and is a dimeric protein. In Homo sapiens, the protein is...; Region: GGCT_like; cd06661 755731010514 putative active site pocket [active] 755731010515 dimerization interface [polypeptide binding]; other site 755731010516 putative catalytic residue [active] 755731010517 Putative amidoligase enzyme; Region: Amidoligase_2; pfam12224 755731010518 Site-specific DNA methylase [DNA replication, recombination, and repair]; Region: Dcm; COG0270 755731010519 Cytosine-C5 specific DNA methylases; Methyl transfer reactions play an important role in many aspects of biology. Cytosine-specific DNA methylases are found both in prokaryotes and eukaryotes. DNA methylation, or the covalent addition of a methyl group...; Region: Cyt_C5_DNA_methylase; cd00315 755731010520 cofactor binding site; other site 755731010521 DNA binding site [nucleotide binding] 755731010522 substrate interaction site [chemical binding]; other site 755731010523 Cytosine-C5 specific DNA methylases; Methyl transfer reactions play an important role in many aspects of biology. Cytosine-specific DNA methylases are found both in prokaryotes and eukaryotes. DNA methylation, or the covalent addition of a methyl group...; Region: Cyt_C5_DNA_methylase; cd00315 755731010524 Protein of unknown function (DUF3852); Region: DUF3852; pfam12963 755731010525 pyruvate dehydrogenase subunit beta; Provisional; Region: PRK11892 755731010526 Domain of unknown function (DUF4320); Region: DUF4320; pfam14208 755731010527 Flp pilus assembly protein, ATPase CpaF [Intracellular trafficking and secretion]; Region: CpaF; COG4962 755731010528 RecA-like NTPases. This family includes the NTP binding domain of F1 and V1 H+ATPases, DnaB and related helicases as well as bacterial RecA and related eukaryotic and archaeal recombinases. This group also includes bacterial conjugation proteins and...; Region: RecA-like_NTPases; cl17233 755731010529 Walker A motif; other site 755731010530 ATP binding site [chemical binding]; other site 755731010531 Walker B motif; other site 755731010532 AAA domain; Region: AAA_31; pfam13614 755731010533 The Fer4_NifH superfamily contains a variety of proteins which share a common ATP-binding domain. Functionally, proteins in this superfamily use the energy from hydrolysis of NTP to transfer electron or ion; Region: Fer4_NifH; cd01983 755731010534 SAF domains of the flagella basal body P-ring formation protein FlgA and the flp pilus assembly CpaB; Region: SAF_CpaB_FlgA_like; cd11614 755731010535 SpoVG; Region: SpoVG; pfam04026 755731010536 YodL-like; Region: YodL; pfam14191 755731010537 S-layer homology domain; Region: SLH; pfam00395 755731010538 Regulators of stationary/sporulation gene expression [Transcription]; Region: AbrB; COG2002 755731010539 Site-specific DNA methylase [DNA replication, recombination, and repair]; Region: Dam; COG0338 755731010540 Antirestriction protein (ArdA); Region: ArdA; cl01953 755731010541 Topoisomerase DNA binding C4 zinc finger; Region: zf-C4_Topoisom; pfam01396 755731010542 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 755731010543 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 755731010544 non-specific DNA binding site [nucleotide binding]; other site 755731010545 salt bridge; other site 755731010546 sequence-specific DNA binding site [nucleotide binding]; other site 755731010547 Predicted ATPase [General function prediction only]; Region: COG5293 755731010548 Uncharacterized protein conserved in bacteria (DUF2326); Region: DUF2326; pfam10088 755731010549 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 755731010550 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 755731010551 non-specific DNA binding site [nucleotide binding]; other site 755731010552 salt bridge; other site 755731010553 sequence-specific DNA binding site [nucleotide binding]; other site 755731010554 Domain of unknown function (DUF4314); Region: DUF4314; pfam14192 755731010555 Protein of unknown function (DUF1444); Region: DUF1444; cl02011 755731010556 Site-specific recombinases, DNA invertase Pin homologs [DNA replication, recombination, and repair]; Region: PinR; COG1961 755731010557 Serine Recombinase family, catalytic domain; a DNA binding domain may be present either N- or C-terminal to the catalytic domain. These enzymes perform site-specific recombination of DNA molecules by a concerted, four-strand cleavage and rejoining...; Region: Ser_Recombinase; cd00338 755731010558 catalytic residues [active] 755731010559 catalytic nucleophile [active] 755731010560 Recombinase; Region: Recombinase; pfam07508 755731010561 Recombinase zinc beta ribbon domain; Region: Zn_ribbon_recom; pfam13408 755731010562 IncA protein; Region: IncA; pfam04156 755731010563 Recombinase; Region: Recombinase; pfam07508 755731010564 Recombinase zinc beta ribbon domain; Region: Zn_ribbon_recom; pfam13408 755731010565 Site-specific recombinases, DNA invertase Pin homologs [DNA replication, recombination, and repair]; Region: PinR; COG1961 755731010566 Serine Recombinase family, catalytic domain; a DNA binding domain may be present either N- or C-terminal to the catalytic domain. These enzymes perform site-specific recombination of DNA molecules by a concerted, four-strand cleavage and rejoining...; Region: Ser_Recombinase; cd00338 755731010567 catalytic residues [active] 755731010568 catalytic nucleophile [active] 755731010569 Recombinase; Region: Recombinase; pfam07508 755731010570 Recombinase zinc beta ribbon domain; Region: Zn_ribbon_recom; pfam13408 755731010571 Site-specific recombinases, DNA invertase Pin homologs [DNA replication, recombination, and repair]; Region: PinR; COG1961 755731010572 Serine Recombinase family, catalytic domain; a DNA binding domain may be present either N- or C-terminal to the catalytic domain. These enzymes perform site-specific recombination of DNA molecules by a concerted, four-strand cleavage and rejoining...; Region: Ser_Recombinase; cd00338 755731010573 catalytic residues [active] 755731010574 catalytic nucleophile [active] 755731010575 RNA polymerase sigma factor, sigma-70 family; Region: sigma70-ECF; TIGR02937 755731010576 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cl17257 755731010577 DNA binding residues [nucleotide binding] 755731010578 GEMM cis-regulatory element; IMG reference gene:2509530267 755731010579 Predicted divalent heavy-metal cations transporter [Inorganic ion transport and metabolism]; Region: COG0428; cl00437 755731010580 heavy metal-(Cd/Co/Hg/Pb/Zn)-translocating P-type ATPase; Region: ATPase-IB2_Cd; TIGR01512 755731010581 E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122 755731010582 Heavy-metal-associated domain; Region: HMA; pfam00403 755731010583 metal-binding site [ion binding] 755731010584 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 755731010585 dimerization interface [polypeptide binding]; other site 755731010586 putative DNA binding site [nucleotide binding]; other site 755731010587 putative Zn2+ binding site [ion binding]; other site 755731010588 arsenical pump-driving ATPase; Region: arsen_driv_ArsA; TIGR04291 755731010589 ArsA ATPase functionas as an efflux pump located on the inner membrane of the cell. This ATP-driven oxyanion pump catalyzes the extrusion of arsenite, antimonite and arsenate. Maintenance of a low intracellular concentration of oxyanion produces...; Region: ArsA; cd02035 755731010590 P loop; other site 755731010591 Nucleotide binding site [chemical binding]; other site 755731010592 DTAP/Switch II; other site 755731010593 Switch I; other site 755731010594 ArsA ATPase functionas as an efflux pump located on the inner membrane of the cell. This ATP-driven oxyanion pump catalyzes the extrusion of arsenite, antimonite and arsenate. Maintenance of a low intracellular concentration of oxyanion produces...; Region: ArsA; cd02035 755731010595 P loop; other site 755731010596 Nucleotide binding site [chemical binding]; other site 755731010597 DTAP/Switch II; other site 755731010598 Switch I; other site 755731010599 Arsenical resistance operon trans-acting repressor ArsD; Region: ArsD; pfam06953 755731010600 Arsenite efflux pump ACR3 and related permeases [Inorganic ion transport and metabolism]; Region: ACR3; COG0798 755731010601 Sodium Bile acid symporter family; Region: SBF; cl17470 755731010602 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 755731010603 dimerization interface [polypeptide binding]; other site 755731010604 putative Zn2+ binding site [ion binding]; other site 755731010605 putative DNA binding site [nucleotide binding]; other site 755731010606 CoA-disulfide reductase; Region: CoA_CoA_reduc; TIGR03385 755731010607 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500 755731010608 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 755731010609 Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain; Region: Pyr_redox_dim; pfam02852 755731010610 Rhodanese Homology Domain (RHOD); an alpha beta fold domain found duplicated in the rhodanese protein. The cysteine containing enzymatically active version of the domain is also found in the Cdc25 class of protein phosphatases and a variety of proteins...; Region: RHOD; cl00125 755731010611 active site residue [active] 755731010612 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 755731010613 dimerization interface [polypeptide binding]; other site 755731010614 putative DNA binding site [nucleotide binding]; other site 755731010615 putative Zn2+ binding site [ion binding]; other site 755731010616 Sortase and related acyltransferases [Cell envelope biogenesis, outer membrane]; Region: COG1247 755731010617 Acetyltransferase (GNAT) family; Region: Acetyltransf_1; pfam00583 755731010618 Methyltransferase domain; Region: Methyltransf_31; pfam13847 755731010619 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 755731010620 S-adenosylmethionine binding site [chemical binding]; other site 755731010621 MarR family; Region: MarR_2; pfam12802 755731010622 helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347 755731010623 Helix-turn-helix domain; Region: HTH_36; pfam13730 755731010624 Type IV secretory system Conjugative DNA transfer; Region: T4SS-DNA_transf; pfam02534 755731010625 RecA-like NTPases. This family includes the NTP binding domain of F1 and V1 H+ATPases, DnaB and related helicases as well as bacterial RecA and related eukaryotic and archaeal recombinases. This group also includes bacterial conjugation proteins and...; Region: RecA-like_NTPases; cl17233 755731010626 Walker A motif; other site 755731010627 ATP binding site [chemical binding]; other site 755731010628 Walker B motif; other site 755731010629 CHC2 zinc finger; Region: zf-CHC2; cl17510 755731010630 Protein of unknown function (DUF3991); Region: DUF3991; pfam13154 755731010631 Toprim-like; Region: Toprim_2; pfam13155 755731010632 active site 755731010633 metal binding site [ion binding]; metal-binding site 755731010634 FOG: TPR repeat, SEL1 subfamily [General function prediction only]; Region: COG0790 755731010635 Sel1-like repeats; Region: SEL1; smart00671 755731010636 Sel1-like repeats; Region: SEL1; smart00671 755731010637 Sel1-like repeats; Region: SEL1; smart00671 755731010638 Sel1-like repeats; Region: SEL1; smart00671 755731010639 FOG: TPR repeat, SEL1 subfamily [General function prediction only]; Region: COG0790 755731010640 Sel1-like repeats; Region: SEL1; smart00671 755731010641 Sel1-like repeats; Region: SEL1; smart00671 755731010642 Sel1-like repeats; Region: SEL1; smart00671 755731010643 Sel1-like repeats; Region: SEL1; smart00671 755731010644 Sel1-like repeats; Region: SEL1; smart00671 755731010645 Plasmid segregation protein ParM and similar proteins; Region: ParM_like; cd10227 755731010646 Mg binding site [ion binding]; other site 755731010647 nucleotide binding site [chemical binding]; other site 755731010648 putative protofilament interface [polypeptide binding]; other site 755731010649 valyl-tRNA synthetase-like protein; Provisional; Region: PTZ00419 755731010650 Cell wall-associated hydrolases (invasion-associated proteins) [Cell envelope biogenesis, outer membrane]; Region: Spr; COG0791 755731010651 NlpC/P60 family; Region: NLPC_P60; cl17555 755731010652 GGCT-like domains, also called AIG2-like family. Gamma-glutamyl cyclotransferase (GGCT) catalyzes the formation of pyroglutamic acid (5-oxoproline) from dipeptides containing gamma-glutamyl, and is a dimeric protein. In Homo sapiens, the protein is...; Region: GGCT_like; cd06661 755731010653 putative active site pocket [active] 755731010654 dimerization interface [polypeptide binding]; other site 755731010655 putative catalytic residue [active] 755731010656 Putative amidoligase enzyme; Region: Amidoligase_2; pfam12224 755731010657 AAA-like domain; Region: AAA_10; pfam12846 755731010658 Domain of unknown function DUF87; Region: DUF87; pfam01935 755731010659 Cytosine-C5 specific DNA methylases; Methyl transfer reactions play an important role in many aspects of biology. Cytosine-specific DNA methylases are found both in prokaryotes and eukaryotes. DNA methylation, or the covalent addition of a methyl group...; Region: Cyt_C5_DNA_methylase; cd00315 755731010660 Site-specific DNA methylase [DNA replication, recombination, and repair]; Region: Dcm; COG0270 755731010661 cofactor binding site; other site 755731010662 DNA binding site [nucleotide binding] 755731010663 substrate interaction site [chemical binding]; other site 755731010664 Cytosine-C5 specific DNA methylases; Methyl transfer reactions play an important role in many aspects of biology. Cytosine-specific DNA methylases are found both in prokaryotes and eukaryotes. DNA methylation, or the covalent addition of a methyl group...; Region: Cyt_C5_DNA_methylase; cd00315 755731010665 Nucleotidyl transferase of unknown function (DUF1814); Region: DUF1814; pfam08843 755731010666 Domain of unknown function (DUF4095); Region: DUF4095; pfam13338 755731010667 Protein of unknown function (DUF4240); Region: DUF4240; pfam14024 755731010668 Cation transport ATPase [Inorganic ion transport and metabolism]; Region: MgtA; COG0474 755731010669 Cation transporter/ATPase, N-terminus; Region: Cation_ATPase_N; pfam00690 755731010670 E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122 755731010671 Putative hydrolase of sodium-potassium ATPase alpha subunit; Region: Hydrolase_like2; pfam13246 755731010672 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 755731010673 motif II; other site 755731010674 Cation transporting ATPase, C-terminus; Region: Cation_ATPase_C; pfam00689 755731010675 Protein of unknown function (DUF3852); Region: DUF3852; pfam12963 755731010676 Domain of unknown function (DUF4320); Region: DUF4320; pfam14208 755731010677 Flp pilus assembly protein TadB [Intracellular trafficking and secretion]; Region: TadB; COG4965 755731010678 Flp pilus assembly protein, ATPase CpaF [Intracellular trafficking and secretion]; Region: CpaF; COG4962 755731010679 RecA-like NTPases. This family includes the NTP binding domain of F1 and V1 H+ATPases, DnaB and related helicases as well as bacterial RecA and related eukaryotic and archaeal recombinases. This group also includes bacterial conjugation proteins and...; Region: RecA-like_NTPases; cl17233 755731010680 Walker A motif; other site 755731010681 ATP binding site [chemical binding]; other site 755731010682 Walker B motif; other site 755731010683 AAA domain; Region: AAA_31; pfam13614 755731010684 The Fer4_NifH superfamily contains a variety of proteins which share a common ATP-binding domain. Functionally, proteins in this superfamily use the energy from hydrolysis of NTP to transfer electron or ion; Region: Fer4_NifH; cd01983 755731010685 Flp pilus assembly protein CpaB [Intracellular trafficking and secretion]; Region: CpaB; COG3745 755731010686 SAF domains of the flagella basal body P-ring formation protein FlgA and the flp pilus assembly CpaB; Region: SAF_CpaB_FlgA_like; cd11614 755731010687 Type IV leader peptidase family; Region: Peptidase_A24; pfam01478 755731010688 SpoVG; Region: SpoVG; pfam04026 755731010689 YodL-like; Region: YodL; pfam14191 755731010690 S-layer homology domain; Region: SLH; pfam00395 755731010691 CRISPR/Cas system-associated RAMP superfamily protein Cas7; Region: Cas7_I-E; cl09608 755731010692 Site-specific DNA methylase [DNA replication, recombination, and repair]; Region: Dam; COG0338 755731010693 Antirestriction protein (ArdA); Region: ArdA; cl01953 755731010694 Domain of unknown function (DUF4314); Region: DUF4314; pfam14192 755731010695 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 755731010696 dimerization interface [polypeptide binding]; other site 755731010697 putative DNA binding site [nucleotide binding]; other site 755731010698 putative Zn2+ binding site [ion binding]; other site 755731010699 Molecular chaperone (small heat shock protein) [Posttranslational modification, protein turnover, chaperones]; Region: IbpA; COG0071 755731010700 Group of bacterial proteins containing an alpha crystallin domain (ACD) similar to Lactobacillus plantarum (Lp) small heat shock proteins (sHsp) HSP 18.5, HSP 18.55 and HSP 19.3. sHsps are molecular chaperones that suppress protein aggregation and...; Region: ACD_LpsHSP_like; cd06471 755731010701 putative dimer interface [polypeptide binding]; other site 755731010702 Predicted membrane protein [Function unknown]; Region: COG4905 755731010703 Protein of unknown function (DUF1113); Region: DUF1113; pfam06541 755731010704 PD-(D/E)XK nuclease superfamily; Region: PDDEXK_4; pfam14281 755731010705 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 755731010706 non-specific DNA binding site [nucleotide binding]; other site 755731010707 salt bridge; other site 755731010708 sequence-specific DNA binding site [nucleotide binding]; other site 755731010709 Site-specific recombinases, DNA invertase Pin homologs [DNA replication, recombination, and repair]; Region: PinR; COG1961 755731010710 Serine Recombinase family, catalytic domain; a DNA binding domain may be present either N- or C-terminal to the catalytic domain. These enzymes perform site-specific recombination of DNA molecules by a concerted, four-strand cleavage and rejoining...; Region: Ser_Recombinase; cd00338 755731010711 catalytic residues [active] 755731010712 catalytic nucleophile [active] 755731010713 Recombinase; Region: Recombinase; pfam07508 755731010714 Recombinase zinc beta ribbon domain; Region: Zn_ribbon_recom; pfam13408 755731010715 Recombinase; Region: Recombinase; pfam07508 755731010716 Site-specific recombinases, DNA invertase Pin homologs [DNA replication, recombination, and repair]; Region: PinR; COG1961 755731010717 Serine Recombinase family, catalytic domain; a DNA binding domain may be present either N- or C-terminal to the catalytic domain. These enzymes perform site-specific recombination of DNA molecules by a concerted, four-strand cleavage and rejoining...; Region: Ser_Recombinase; cd00338 755731010718 catalytic residues [active] 755731010719 catalytic nucleophile [active] 755731010720 Recombinase; Region: Recombinase; pfam07508 755731010721 Recombinase zinc beta ribbon domain; Region: Zn_ribbon_recom; pfam13408 755731010722 Polymerase I functions primarily to fill DNA gaps that arise during DNA repair, recombination and replication; Region: DNA_pol_A_pol_I_A; cd08642 755731010723 active site 755731010724 DNA binding site [nucleotide binding] 755731010725 catalytic site [active] 755731010726 Protein of unknown function (DUF2815); Region: DUF2815; pfam10991 755731010727 Protein of unknown function (DUF2800); Region: DUF2800; pfam10926 755731010728 Peptidoglycan recognition proteins (PGRPs) are pattern recognition receptors that bind, and in certain cases, hydrolyze peptidoglycans (PGNs) of bacterial cell walls. PGRPs have been divided into three classes: short PGRPs (PGRP-S), that are small (20...; Region: PGRP; cd06583 755731010729 amidase catalytic site [active] 755731010730 Zn binding residues [ion binding]; other site 755731010731 substrate binding site [chemical binding]; other site 755731010732 LysM domain/BON superfamily protein; Provisional; Region: PRK11198 755731010733 Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118 755731010734 Holin family; Region: Phage_holin_4; pfam05105 755731010735 Phage tail protein; Region: Sipho_tail; pfam05709 755731010736 Phage-related protein [Function unknown]; Region: COG5412 755731010737 membrane protein P6; Region: PHA01399 755731010738 phage major tail protein, phi13 family; Region: maj_tail_phi13; TIGR01603 755731010739 Bacteriophage protein of unknown function (DUF646); Region: DUF646; pfam04883 755731010740 Phage head-tail joining protein; Region: Phage_H_T_join; pfam05521 755731010741 Head-Tail Connector Protein gp6 of Bacteriophage HK97 and similar proteins; Region: gp6; cd08054 755731010742 oligomerization interface [polypeptide binding]; other site 755731010743 Head fiber protein; Region: Phage_head_fibr; pfam11133 755731010744 phage major capsid protein, HK97 family; Region: major_cap_HK97; TIGR01554 755731010745 Phage capsid family; Region: Phage_capsid; pfam05065 755731010746 Caseinolytic protease (ClpP) is an ATP-dependent, highly conserved serine protease; Region: S14_ClpP_1; cd07016 755731010747 oligomer interface [polypeptide binding]; other site 755731010748 active site residues [active] 755731010749 Phage-related protein [Function unknown]; Region: COG4695 755731010750 Phage portal protein; Region: Phage_portal; pfam04860 755731010751 Phage terminase-like protein, large subunit [General function prediction only]; Region: COG4626 755731010752 GGCT-like domains, also called AIG2-like family. Gamma-glutamyl cyclotransferase (GGCT) catalyzes the formation of pyroglutamic acid (5-oxoproline) from dipeptides containing gamma-glutamyl, and is a dimeric protein. In Homo sapiens, the protein is...; Region: GGCT_like; cd06661 755731010753 putative active site pocket [active] 755731010754 dimerization interface [polypeptide binding]; other site 755731010755 putative catalytic residue [active] 755731010756 Putative amidoligase enzyme; Region: Amidoligase_2; pfam12224 755731010757 Cytosine-C5 specific DNA methylases; Methyl transfer reactions play an important role in many aspects of biology. Cytosine-specific DNA methylases are found both in prokaryotes and eukaryotes. DNA methylation, or the covalent addition of a methyl group...; Region: Cyt_C5_DNA_methylase; cd00315 755731010758 cofactor binding site; other site 755731010759 DNA binding site [nucleotide binding] 755731010760 substrate interaction site [chemical binding]; other site 755731010761 Cytosine-C5 specific DNA methylases; Methyl transfer reactions play an important role in many aspects of biology. Cytosine-specific DNA methylases are found both in prokaryotes and eukaryotes. DNA methylation, or the covalent addition of a methyl group...; Region: Cyt_C5_DNA_methylase; cd00315 755731010762 Stage 0 sporulation protein J (antagonist of Soj) containing ParB-like nuclease domain [Transcription]; Region: Spo0J; COG1475 755731010763 ParB-like nuclease domain; Region: ParBc; pfam02195 755731010764 DNA modification methylase [DNA replication, recombination, and repair]; Region: COG0863 755731010765 DNA methylase; Region: N6_N4_Mtase; pfam01555 755731010766 S-adenosylmethionine synthetase; Provisional; Region: PRK12459 755731010767 S-adenosylmethionine synthetase, N-terminal domain; Region: S-AdoMet_synt_N; pfam00438 755731010768 S-adenosylmethionine synthetase, central domain; Region: S-AdoMet_synt_M; pfam02772 755731010769 S-adenosylmethionine synthetase, C-terminal domain; Region: S-AdoMet_synt_C; pfam02773 755731010770 Phage terminase, small subunit; Region: Terminase_4; cl01525 755731010771 Restriction endonuclease [Defense mechanisms]; Region: McrA; COG1403 755731010772 HNH nucleases; HNH endonuclease signature which is found in viral, prokaryotic, and eukaryotic proteins. The alignment includes members of the large group of homing endonucleases, yeast intron 1 protein, MutS, as well as bacterial colicins, pyocins, and...; Region: HNHc; cd00085 755731010773 active site 755731010774 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 755731010775 DNA binding residues [nucleotide binding] 755731010776 VRR-NUC domain; Region: VRR_NUC; pfam08774 755731010777 Virulence-associated protein E; Region: VirE; pfam05272 755731010778 Protein of unknown function (DUF790); Region: DUF790; pfam05626 755731010779 Uncharacterized phage-encoded protein [Function unknown]; Region: COG3646 755731010780 Phage regulatory protein Rha (Phage_pRha); Region: Phage_pRha; pfam09669 755731010781 RNA polymerase sigma factor, sigma-70 family; Region: sigma70-ECF; TIGR02937 755731010782 Type I site-specific restriction-modification system, R (restriction) subunit and related helicases [Defense mechanisms]; Region: COG0610 755731010783 Type I restriction enzyme R protein N terminus (HSDR_N); Region: HSDR_N; pfam04313 755731010784 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 755731010785 ATP binding site [chemical binding]; other site 755731010786 putative Mg++ binding site [ion binding]; other site 755731010787 Type I restriction and modification enzyme - subunit R C terminal; Region: EcoR124_C; pfam12008 755731010788 Type I restriction modification DNA specificity domain; Region: Methylase_S; pfam01420 755731010789 Restriction endonuclease S subunits [Defense mechanisms]; Region: HsdS; COG0732 755731010790 Type I restriction modification DNA specificity domain; Region: Methylase_S; pfam01420 755731010791 HsdM N-terminal domain; Region: HsdM_N; pfam12161 755731010792 N-6 DNA Methylase; Region: N6_Mtase; pfam02384 755731010793 Methyltransferase domain; Region: Methyltransf_26; pfam13659 755731010794 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cl17200 755731010795 SAM-dependent methyltransferases related to tRNA (uracil-5-)-methyltransferase [Translation, ribosomal structure and biogenesis]; Region: TrmA; COG2265 755731010796 TRAM domain; Region: TRAM; pfam01938 755731010797 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 755731010798 S-adenosylmethionine binding site [chemical binding]; other site 755731010799 G:T/U mismatch specific DNA glcosylase (MUG); Region: UDG_F2_MUG; cd10028 755731010800 active site 755731010801 SUMO-1 interface [polypeptide binding]; other site 755731010802 Sporulation protein YtfJ (Spore_YtfJ); Region: Spore_YtfJ; pfam09579 755731010803 Membrane protein of unknown function; Region: DUF360; pfam04020 755731010804 Methyl-accepting chemotaxis protein [Cell motility and secretion / Signal transduction mechanisms]; Region: Tar; COG0840 755731010805 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 755731010806 dimerization interface [polypeptide binding]; other site 755731010807 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 755731010808 dimer interface [polypeptide binding]; other site 755731010809 putative CheW interface [polypeptide binding]; other site 755731010810 Membrane proteins related to metalloendopeptidases [Cell envelope biogenesis, outer membrane]; Region: NlpD; COG0739 755731010811 Peptidase family M23; Region: Peptidase_M23; pfam01551 755731010812 Transglycosylase; Region: Transgly; pfam00912 755731010813 penicillin-binding protein, 1A family; Region: PBP_1a_fam; TIGR02074 755731010814 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; cl17760 755731010815 gamma-glutamyl kinase; Provisional; Region: PRK05429 755731010816 AAK_G5K_ProB: Glutamate-5-kinase (G5K) catalyzes glutamate-dependent ATP cleavage; G5K transfers the terminal phosphoryl group of ATP to the gamma-carboxyl group of glutamate, in the first and controlling step of proline (and, in mammals, ornithine)...; Region: AAK_G5K_ProB; cd04242 755731010817 nucleotide binding site [chemical binding]; other site 755731010818 homotetrameric interface [polypeptide binding]; other site 755731010819 putative phosphate binding site [ion binding]; other site 755731010820 putative allosteric binding site; other site 755731010821 PAP2_like proteins, Aur1_like subfamily. Yeast Aur1p or Ipc1p is necessary for the addition of inositol phosphate to ceramide, an essential step in yeast sphingolipid synthesis, and is the target of several antifungal compounds such as aureobasidin; Region: PAP2_Aur1_like; cd03386 755731010822 active site 755731010823 Elongation factor G (EF-G) family; Region: EF-G_bact; cd04170 755731010824 elongation factor G; Reviewed; Region: PRK12740 755731010825 G1 box; other site 755731010826 putative GEF interaction site [polypeptide binding]; other site 755731010827 GTP/Mg2+ binding site [chemical binding]; other site 755731010828 Switch I region; other site 755731010829 G2 box; other site 755731010830 G3 box; other site 755731010831 Switch II region; other site 755731010832 G4 box; other site 755731010833 G5 box; other site 755731010834 EFG_mtEFG_II: this subfamily represents the domain II of elongation factor G (EF-G) in bacteria and, the C-terminus of mitochondrial Elongation factor G1 (mtEFG1) and G2 (mtEFG2)_like proteins found in eukaryotes. During the process of peptide synthesis...; Region: EFG_mtEFG_II; cd04088 755731010835 Elongation Factor G-like domain IV. This family includes the translational elongation factor termed EF-2 (for Archaea and Eukarya) and EF-G (for Bacteria), ribosomal protection proteins that mediate tetracycline resistance and, an evolutionarily...; Region: EFG_like_IV; cl02789 755731010836 EFG_mtEFG_C: domains similar to the C-terminal domain of the bacterial translational elongation factor (EF) EF-G. Included in this group is the C-terminus of mitochondrial Elongation factor G1 (mtEFG1) and G2 (mtEFG2) proteins. Eukaryotic cells harbor 2...; Region: EFG_mtEFG_C; cd03713 755731010837 3-deoxy-7-phosphoheptulonate synthase; Reviewed; Region: PRK08673 755731010838 phospho-2-dehydro-3-deoxyheptonate aldolase; Region: DAHP_synth_Bsub; TIGR01361 755731010839 prephenate dehydrogenase; Validated; Region: PRK06545 755731010840 prephenate dehydrogenase; Validated; Region: PRK08507 755731010841 C-terminal ACT domain of the monofunctional, NAD dependent, prephenate dehydrogenase (PDH); Region: ACT_PDH-BS; cd04909 755731010842 redox-sensing transcriptional repressor Rex; Provisional; Region: PRK05472 755731010843 Putative DNA-binding protein N-terminus; Region: Put_DNA-bind_N; pfam06971 755731010844 CoA binding domain; Region: CoA_binding; pfam02629 755731010845 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 755731010846 This family is most closely related to the GT1 family of glycosyltransferases and named after YqgM in Bacillus licheniformis about which little is known. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to...; Region: GT1_YqgM_like; cd03801 755731010847 polysaccharide pyruvyl transferase CsaB; Region: S_layer_CsaB; TIGR03609 755731010848 ATPase components of ABC transporters with duplicated ATPase domains [General function prediction only]; Region: Uup; COG0488 755731010849 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 755731010850 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 755731010851 Walker A/P-loop; other site 755731010852 ATP binding site [chemical binding]; other site 755731010853 Q-loop/lid; other site 755731010854 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 755731010855 ABC transporter signature motif; other site 755731010856 Walker B; other site 755731010857 D-loop; other site 755731010858 ABC transporter; Region: ABC_tran_2; pfam12848 755731010859 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 755731010860 3-oxoacyl-[acyl-carrier-protein]; Region: FabH; COG0332 755731010861 Condensing enzymes; Family of enzymes that catalyze a (decarboxylating or non-decarboxylating) Claisen-like condensation reaction. Members are share strong structural similarity, and are involved in the synthesis and degradation of fatty acids, and the...; Region: cond_enzymes; cl09938 755731010862 active site 755731010863 Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer); Region: MA; smart00283 755731010864 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 755731010865 dimer interface [polypeptide binding]; other site 755731010866 putative CheW interface [polypeptide binding]; other site 755731010867 3-oxoacyl-[acyl-carrier-protein]; Region: FabH; COG0332 755731010868 Ketoacyl-acyl carrier protein synthase III (KASIII) initiates the elongation in type II fatty acid synthase systems. It is found in bacteria and plants. Elongation of fatty acids in the type II systems occurs by Claisen condensation of malonyl-acyl...; Region: KAS_III; cd00830 755731010869 dimer interface [polypeptide binding]; other site 755731010870 active site 755731010871 CoA binding pocket [chemical binding]; other site 755731010872 Domain of unknown function (DUF4118); Region: DUF4118; pfam13493 755731010873 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 755731010874 dimer interface [polypeptide binding]; other site 755731010875 Methyl-accepting chemotaxis protein (MCP) signalling domain; Region: MCPsignal; pfam00015 755731010876 putative CheW interface [polypeptide binding]; other site 755731010877 N-acetylmuramoyl-L-alanine amidase [Cell envelope biogenesis, outer membrane]; Region: AmiC; COG0860 755731010878 N-acetylmuramoyl-L-alanine amidase or MurNAc-LAA (also known as peptidoglycan aminohydrolase, NAMLA amidase, NAMLAA, Amidase 3, and peptidoglycan amidase; EC 3.5.1.28) is an autolysin that hydrolyzes the amide bond between N-acetylmuramoyl and L-amino...; Region: MurNAc-LAA; cd02696 755731010879 active site 755731010880 metal binding site [ion binding]; metal-binding site 755731010881 The GH18 (glycosyl hydrolase, family 18) type II chitinases hydrolyze chitin, an abundant polymer of beta-1,4-linked N-acetylglucosamine (GlcNAc) which is a major component of the cell wall of fungi and the exoskeleton of arthropods. Chitinases have...; Region: GH18_chitinase-like; cl10447 755731010882 active site 755731010883 Glycosyl hydrolases family 18; Region: Glyco_hydro_18; pfam00704 755731010884 Leucine Rich repeats (2 copies); Region: LRR_4; pfam12799 755731010885 Leucine Rich repeats (2 copies); Region: LRR_4; pfam12799 755731010886 Protein of unknown function (DUF964); Region: DUF964; pfam06133 755731010887 Hemerythrin HHE cation binding domain; Region: Hemerythrin; pfam01814 755731010888 Protein of unknown function (DUF2812); Region: DUF2812; pfam11193 755731010889 Predicted transcriptional regulators [Transcription]; Region: COG1695 755731010890 Transcriptional regulator PadR-like family; Region: PadR; cl17335 755731010891 DinB superfamily; Region: DinB_2; pfam12867 755731010892 ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136 755731010893 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 755731010894 Walker A/P-loop; other site 755731010895 ATP binding site [chemical binding]; other site 755731010896 Q-loop/lid; other site 755731010897 ABC transporter signature motif; other site 755731010898 Walker B; other site 755731010899 D-loop; other site 755731010900 H-loop/switch region; other site 755731010901 ABC-2 family transporter protein; Region: ABC2_membrane_6; cl01496 755731010902 ABC-type uncharacterized transport system, permease component [General function prediction only]; Region: COG4587 755731010903 ABC-type uncharacterized transport system, permease component [General function prediction only]; Region: COG4587 755731010904 The adenylation domain of nonribosomal peptide synthetases (NRPS); Region: A_NRPS; cd05930 755731010905 amino acid adenylation domain; Region: AA-adenyl-dom; TIGR01733 755731010906 acyl-activating enzyme (AAE) consensus motif; other site 755731010907 AMP binding site [chemical binding]; other site 755731010908 B12 binding domain; Region: B12-binding; pfam02310 755731010909 B12 binding site [chemical binding]; other site 755731010910 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 755731010911 Elongator protein 3, MiaB family, Radical SAM; Region: Elp3; smart00729 755731010912 FeS/SAM binding site; other site 755731010913 Phosphopantetheine attachment site; Region: PP-binding; cl09936 755731010914 hybrid cluster protein; Provisional; Region: PRK05290 755731010915 The HCP family of iron-sulfur proteins includes hybrid cluster protein (HCP), acetyl-CoA synthase (ACS), and carbon monoxide dehydrogenase (CODH), all of which contain [Fe4-S4] metal clusters at their active sites. These proteins have a conserved...; Region: HCP_like; cl14655 755731010916 ACS interaction site; other site 755731010917 CODH interaction site; other site 755731010918 Hybrid cluster protein (HCP), formerly known as prismane, is thought to play a role in nitrogen metabolism but its specific function is unknown. HCP has three structural domains, an N-terminal alpha-helical domain, and two similar domains comprising a...; Region: HCP; cd01914 755731010919 hybrid metal cluster; other site 755731010920 Hsp33-like chaperonin; Reviewed; Region: hslO; PRK00114 755731010921 Heat shock protein 33 (Hsp33): Cytosolic protein that acts as a molecular chaperone under oxidative conditions. In normal (reducing) cytosolic conditions, four conserved Cys residues are coordinated by a Zn ion. Under oxidative stress (such as heat...; Region: Hsp33; cd00498 755731010922 dimerization interface [polypeptide binding]; other site 755731010923 domain crossover interface; other site 755731010924 redox-dependent activation switch; other site 755731010925 Cold-Shock Protein (CSP) contains an S1-like cold-shock domain (CSD) that is found in eukaryotes, prokaryotes, and archaea. CSP's include the major cold-shock proteins CspA and CspB in bacteria and the eukaryotic gene regulatory factor Y-box...; Region: CSP_CDS; cd04458 755731010926 DNA-binding site [nucleotide binding]; DNA binding site 755731010927 RNA-binding motif; other site 755731010928 Methyltransferase domain; Region: Methyltransf_31; pfam13847 755731010929 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 755731010930 S-adenosylmethionine binding site [chemical binding]; other site 755731010931 Small, acid-soluble spore proteins, alpha/beta type; Region: SASP; pfam00269 755731010932 C-terminal processing peptidase family S41; Region: Peptidase_S41; cl02526 755731010933 C-terminal peptidase (prc); Region: prc; TIGR00225 755731010934 PDZ domain of C-terminal processing-, tail-specific-, and tricorn proteases, which function in posttranslational protein processing, maturation, and disassembly or degradation, in Bacteria, Archaea, and plant chloroplasts. May be responsible for...; Region: PDZ_CTP_protease; cd00988 755731010935 protein binding site [polypeptide binding]; other site 755731010936 C-terminal processing peptidase; serine protease family S41; Region: Peptidase_S41_CPP; cd07560 755731010937 Catalytic dyad [active] 755731010938 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3883 755731010939 Membrane proteins related to metalloendopeptidases [Cell envelope biogenesis, outer membrane]; Region: NlpD; COG0739 755731010940 Peptidase family M23; Region: Peptidase_M23; pfam01551 755731010941 Cell division protein [Cell division and chromosome partitioning]; Region: FtsX; COG2177 755731010942 cell division ABC transporter subunit FtsX; Provisional; Region: ftsX; PRK11026 755731010943 Predicted ATPase involved in cell division [Cell division and chromosome partitioning]; Region: FtsE; COG2884 755731010944 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 755731010945 Walker A/P-loop; other site 755731010946 ATP binding site [chemical binding]; other site 755731010947 Q-loop/lid; other site 755731010948 ABC transporter signature motif; other site 755731010949 Walker B; other site 755731010950 D-loop; other site 755731010951 H-loop/switch region; other site 755731010952 PucR C-terminal helix-turn-helix domain; Region: HTH_30; pfam13556 755731010953 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 755731010954 Major Facilitator Superfamily; Region: MFS_1; pfam07690 755731010955 putative substrate translocation pore; other site 755731010956 Bacterial transcription activator, effector binding domain; Region: AraC_E_bind; smart00871 755731010957 Protein of unknown function (DUF2589); Region: DUF2589; pfam11655 755731010958 Protein of unknown function (DUF2589); Region: DUF2589; pfam11655 755731010959 GIY-YIG nuclease domain superfamily; Region: GIY-YIG_SF; cl15257 755731010960 GIY-YIG motif/motif A; other site 755731010961 active site 755731010962 catalytic site [active] 755731010963 glycerol-3-phosphate transporter ATP-binding subunit; Provisional; Region: ugpC; PRK11650 755731010964 The N-terminal ATPase domain of the maltose transporter, MalK; Region: ABC_MalK_N; cd03301 755731010965 Walker A/P-loop; other site 755731010966 ATP binding site [chemical binding]; other site 755731010967 Q-loop/lid; other site 755731010968 ABC transporter signature motif; other site 755731010969 Walker B; other site 755731010970 D-loop; other site 755731010971 H-loop/switch region; other site 755731010972 TOBE domain; Region: TOBE_2; pfam08402 755731010973 N-acetyl-gamma-glutamyl-phosphate reductase; Provisional; Region: PRK11863 755731010974 Semialdehyde dehydrogenase, NAD binding domain; Region: Semialdhyde_dh; smart00859 755731010975 AAK_NAGK-C: N-Acetyl-L-glutamate kinase - cyclic (NAGK-C) catalyzes the phosphorylation of the gamma-COOH group of N-acetyl-L-glutamate (NAG) by ATP in the second step of arginine biosynthesis found in some bacteria and photosynthetic organisms using the...; Region: AAK_NAGK-C; cd04250 755731010976 feedback inhibition sensing region; other site 755731010977 homohexameric interface [polypeptide binding]; other site 755731010978 nucleotide binding site [chemical binding]; other site 755731010979 N-acetyl-L-glutamate binding site [chemical binding]; other site 755731010980 acetylornithine aminotransferase; Provisional; Region: PRK02627 755731010981 Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610 755731010982 inhibitor-cofactor binding pocket; inhibition site 755731010983 pyridoxal 5'-phosphate binding site [chemical binding]; other site 755731010984 catalytic residue [active] 755731010985 carbamoyl phosphate synthase small subunit; Reviewed; Region: PRK12564 755731010986 Carbamoyl-phosphate synthase small chain, CPSase domain; Region: CPSase_sm_chain; pfam00988 755731010987 Small chain of the glutamine-dependent form of carbamoyl phosphate synthase, CPSase II; Region: GATase1_CPSase; cd01744 755731010988 catalytic site [active] 755731010989 subunit interface [polypeptide binding]; other site 755731010990 carbamoyl phosphate synthase large subunit; Reviewed; Region: carB; PRK05294 755731010991 Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289 755731010992 Carbamoyl-phosphate synthase L chain, ATP binding domain; Region: CPSase_L_D2; pfam02786 755731010993 Carbamoyl-phosphate synthetase large chain, oligomerisation domain; Region: CPSase_L_D3; pfam02787 755731010994 Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289 755731010995 ATP-grasp domain; Region: ATP-grasp_4; cl17255 755731010996 Methylglyoxal synthase-like domain from type II glutamine-dependent carbamoyl phosphate synthetase (CSP). CSP, a CarA and CarB heterodimer, catalyzes the production of carbamoyl phosphate which is subsequently employed in the metabolic pathways...; Region: MGS_CPS_II; cd01424 755731010997 IMP binding site; other site 755731010998 dimer interface [polypeptide binding]; other site 755731010999 interdomain contacts; other site 755731011000 partial ornithine binding site; other site 755731011001 ornithine carbamoyltransferase; Provisional; Region: PRK00779 755731011002 Aspartate/ornithine carbamoyltransferase, carbamoyl-P binding domain; Region: OTCace_N; pfam02729 755731011003 Aspartate/ornithine carbamoyltransferase, Asp/Orn binding domain; Region: OTCace; pfam00185 755731011004 Acetyltransferases [General function prediction only]; Region: RimI; COG0456 755731011005 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 755731011006 Coenzyme A binding pocket [chemical binding]; other site 755731011007 Domain of unknown function (DUF3794); Region: DUF3794; pfam12673 755731011008 Carbon monoxide dehydrogenase (CODH) is found in acetogenic and methanogenic organisms and is responsible for the synthesis and breakdown of acetyl-CoA, respectively. CODH has two types of metal clusters, a cubane [Fe4-S4] center (B-cluster) similar to...; Region: CODH; cd01915 755731011009 carbon-monoxide dehydrogenase, catalytic subunit; Region: CO_DH_cata; TIGR01702 755731011010 ACS interaction site; other site 755731011011 CODH interaction site; other site 755731011012 cubane metal cluster (B-cluster) [ion binding]; other site 755731011013 Ni-Fe-S cluster (C-cluster) [ion binding]; other site 755731011014 Cupin domain; Region: Cupin_2; pfam07883 755731011015 Uncharacterized conserved protein [Function unknown]; Region: COG1284 755731011016 Uncharacterized BCR, YitT family COG1284; Region: DUF161; pfam02588 755731011017 Uncharacterized protein conserved in bacteria (DUF2179); Region: DUF2179; pfam10035 755731011018 Teichoic acid biosynthesis proteins [Cell envelope biogenesis, outer membrane]; Region: WecG; COG1922 755731011019 The glycosyltransferase WecG/TagA superfamily contains Escherichia coli WecG, Bacillus subtilis TagA and related proteins. E. coli WecG is believed to be a UDP-N-acetyl-D-mannosaminuronic acid transferase, and is involved in enterobacterial common...; Region: Glyco_transf_WecG_TagA; cd06533 755731011020 FAD dependent oxidoreductase; Region: FAD_oxidored; pfam12831 755731011021 PemK-like protein; Region: PemK; pfam02452 755731011022 Predicted transcriptional regulators containing the CopG/Arc/MetJ DNA-binding domain and a metal-binding domain [Transcription]; Region: NikR; COG0864 755731011023 alanine racemase; Reviewed; Region: alr; PRK00053 755731011024 Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzyme Alanine Racemase; Region: PLPDE_III_AR; cd00430 755731011025 active site 755731011026 pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site 755731011027 dimer interface [polypeptide binding]; other site 755731011028 substrate binding site [chemical binding]; other site 755731011029 catalytic residues [active] 755731011030 YjeF-related protein N-terminus; Region: YjeF_N; pfam03853 755731011031 B.subtilis YXKO protein of unknown function and related proteins. Based on the conservation of the ATP binding site, the substrate binding site and the Mg2+binding site and structural homology this group is a member of the ribokinase-like superfamily; Region: YXKO-related; cd01171 755731011032 putative substrate binding site [chemical binding]; other site 755731011033 putative ATP binding site [chemical binding]; other site 755731011034 phosphodiesterase; Provisional; Region: PRK12704 755731011035 UDP-N-acetyl-D-mannosaminuronate dehydrogenase [Cell envelope biogenesis, outer membrane]; Region: WecC; COG0677 755731011036 UDP-glucose/GDP-mannose dehydrogenase family, central domain; Region: UDPG_MGDP_dh; pfam00984 755731011037 UDP-glucose/GDP-mannose dehydrogenase family, UDP binding domain; Region: UDPG_MGDP_dh_C; pfam03720 755731011038 This family is most closely related to the GT1 family of glycosyltransferases. wbuB in E. coli is involved in the biosynthesis of the O26 O-antigen. It has been proposed to function as an N-acetyl-L-fucosamine (L-FucNAc) transferase; Region: GT1_wbuB_like; cd03794 755731011039 Glycosyltransferase Family 4; Region: Glyco_transf_4; pfam13439 755731011040 Domain of unknown function (DUF4330); Region: DUF4330; pfam14221 755731011041 O-Antigen ligase; Region: Wzy_C; cl04850 755731011042 Lipid A core - O-antigen ligase and related enzymes [Cell envelope biogenesis, outer membrane]; Region: RfaL; COG3307 755731011043 Dolichyl-phosphate-mannose-protein mannosyltransferase; Region: PMT_2; pfam13231 755731011044 NADH pyrophosphatase; Reviewed; Region: nudC; PRK00241 755731011045 NADH pyrophosphatase-like rudimentary NUDIX domain; Region: NUDIX-like; pfam09296 755731011046 NADH pyrophosphatase zinc ribbon domain; Region: zf-NADH-PPase; pfam09297 755731011047 NADH pyrophosphatase, a member of the Nudix hydrolase superfamily, catalyzes the cleavage of NADH into reduced nicotinamide mononucleotide (NMNH) and AMP. Like other members of the Nudix family, it requires a divalent cation, such as Mg2+ or Mn2+, for...; Region: NADH_pyrophosphatase; cd03429 755731011048 putative NADH binding site [chemical binding]; other site 755731011049 putative active site [active] 755731011050 nudix motif; other site 755731011051 putative metal binding site [ion binding]; other site 755731011052 Molecular chaperone (small heat shock protein) [Posttranslational modification, protein turnover, chaperones]; Region: IbpA; COG0071 755731011053 Group of bacterial proteins containing an alpha crystallin domain (ACD) similar to Lactobacillus plantarum (Lp) small heat shock proteins (sHsp) HSP 18.5, HSP 18.55 and HSP 19.3. sHsps are molecular chaperones that suppress protein aggregation and...; Region: ACD_LpsHSP_like; cd06471 755731011054 putative dimer interface [polypeptide binding]; other site 755731011055 stage V sporulation protein B; Region: spore_V_B; TIGR02900 755731011056 Stage V sporulation protein B, also known as Stage III sporulation protein F, and related proteins; Region: MATE_SpoVB_like; cd13124 755731011057 Cell wall-associated hydrolases (invasion-associated proteins) [Cell envelope biogenesis, outer membrane]; Region: Spr; COG0791 755731011058 NlpC/P60 family; Region: NLPC_P60; pfam00877 755731011059 N-acetylmuramoyl-L-alanine amidase or MurNAc-LAA (also known as peptidoglycan aminohydrolase, NAMLA amidase, NAMLAA, Amidase 3, and peptidoglycan amidase; EC 3.5.1.28) is an autolysin that hydrolyzes the amide bond between N-acetylmuramoyl and L-amino...; Region: MurNAc-LAA; cd02696 755731011060 N-acetylmuramoyl-L-alanine amidase [Cell envelope biogenesis, outer membrane]; Region: AmiC; COG0860 755731011061 active site 755731011062 metal binding site [ion binding]; metal-binding site 755731011063 putative TIM-barrel protein, nifR3 family; Region: nifR3_yhdG; TIGR00737 755731011064 Dihydrouridine synthase-like (DUS-like) FMN-binding domain. Members of this family catalyze the reduction of the 5,6-double bond of a uridine residue on tRNA. Dihydrouridine modification of tRNA is widely observed in prokaryotes and eukaryotes, and also...; Region: DUS_like_FMN; cd02801 755731011065 FMN binding site [chemical binding]; other site 755731011066 active site 755731011067 catalytic residues [active] 755731011068 substrate binding site [chemical binding]; other site 755731011069 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 755731011070 Methyltransferase domain; Region: Methyltransf_31; pfam13847 755731011071 S-adenosylmethionine binding site [chemical binding]; other site 755731011072 Haemolysin XhlA; Region: XhlA; pfam10779 755731011073 Predicted transcriptional regulator [Transcription]; Region: COG2345 755731011074 Site-specific recombinases, DNA invertase Pin homologs [DNA replication, recombination, and repair]; Region: PinR; COG1961 755731011075 Serine Recombinase (SR) family, Resolvase and Invertase subfamily, catalytic domain; members contain a C-terminal DNA binding domain. Serine recombinases catalyze site-specific recombination of DNA molecules by a concerted, four-strand cleavage and...; Region: SR_ResInv; cd03768 755731011076 catalytic residues [active] 755731011077 catalytic nucleophile [active] 755731011078 Presynaptic Site I dimer interface [polypeptide binding]; other site 755731011079 Synaptic Antiparallel dimer interface [polypeptide binding]; other site 755731011080 Synaptic Flat tetramer interface [polypeptide binding]; other site 755731011081 Synaptic Site I dimer interface [polypeptide binding]; other site 755731011082 DNA binding site [nucleotide binding] 755731011083 Phage portal protein, SPP1 Gp6-like; Region: Phage_prot_Gp6; pfam05133 755731011084 large terminase protein; Provisional; Region: 17; PHA02533 755731011085 Terminase-like family; Region: Terminase_6; pfam03237 755731011086 CHC2 zinc finger; Region: zf-CHC2; cl17510 755731011087 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cl17200 755731011088 salt bridge; other site 755731011089 non-specific DNA binding site [nucleotide binding]; other site 755731011090 sequence-specific DNA binding site [nucleotide binding]; other site 755731011091 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 755731011092 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 755731011093 non-specific DNA binding site [nucleotide binding]; other site 755731011094 salt bridge; other site 755731011095 sequence-specific DNA binding site [nucleotide binding]; other site 755731011096 site-specific tyrosine recombinase XerC; Reviewed; Region: xerC; PRK00236 755731011097 DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213 755731011098 active site 755731011099 DNA binding site [nucleotide binding] 755731011100 Int/Topo IB signature motif; other site 755731011101 Protein of unknown function (DUF2837); Region: DUF2837; pfam10997 755731011102 stage II sporulation protein E; Region: spore_II_E; TIGR02865 755731011103 Sigma factor PP2C-like phosphatases; Region: PP2C_SIG; smart00331 755731011104 nicotinate phosphoribosyltransferase; Validated; Region: PRK09243 755731011105 Nicotinate phosphoribosyltransferase (NAPRTase), subgroup A. Nicotinate phosphoribosyltransferase catalyses the formation of NAMN and PPi from 5-phosphoribosy -1-pyrophosphate (PRPP) and nicotinic acid, this is the first, and also rate limiting, reaction...; Region: NAPRTase_A; cd01570 755731011106 active site 755731011107 Uncharacterized conserved protein [Function unknown]; Region: COG1284 755731011108 Uncharacterized BCR, YitT family COG1284; Region: DUF161; pfam02588 755731011109 Uncharacterized protein conserved in bacteria (DUF2179); Region: DUF2179; pfam10035 755731011110 Trypsin-like peptidase domain; Region: Trypsin_2; pfam13365 755731011111 PDZ domain, also called DHR (Dlg homologous region) or GLGF (after a conserved sequence motif). Many PDZ domains bind C-terminal polypeptides, though binding to internal (non-C-terminal) polypeptides and even to lipids has been demonstrated; Region: PDZ; cl00117 755731011112 protein binding site [polypeptide binding]; other site 755731011113 Histone acetyltransferase HPA2 and related acetyltransferases [Transcription / General function prediction only]; Region: WecD; COG0454 755731011114 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 755731011115 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl17182 755731011116 Coenzyme A binding pocket [chemical binding]; other site 755731011117 methionine sulfoxide reductase A; Provisional; Region: PRK14054 755731011118 Protein of unknown function (DUF503); Region: DUF503; pfam04456 755731011119 Uncharacterized ACR, YkgG family COG1556; Region: DUF162; pfam02589 755731011120 Uncharacterized BCR, YaiI/YqxD family COG1671; Region: DUF188; cl00727 755731011121 Carbohydrate binding module 27; Region: CBM27; pfam09212 755731011122 Carbohydrate binding module 27; Region: CBM27; pfam09212 755731011123 Carbohydrate binding module 27; Region: CBM27; pfam09212 755731011124 Glycosyl hydrolase family 26; Region: Glyco_hydro_26; pfam02156 755731011125 ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395 755731011126 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 755731011127 dimer interface [polypeptide binding]; other site 755731011128 conserved gate region; other site 755731011129 putative PBP binding loops; other site 755731011130 ABC-ATPase subunit interface; other site 755731011131 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 755731011132 dimer interface [polypeptide binding]; other site 755731011133 conserved gate region; other site 755731011134 putative PBP binding loops; other site 755731011135 ABC-ATPase subunit interface; other site 755731011136 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; pfam01547 755731011137 Bacterial extracellular solute-binding protein; Region: SBP_bac_8; pfam13416 755731011138 Transcriptional regulators [Transcription]; Region: PurR; COG1609 755731011139 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 755731011140 DNA binding site [nucleotide binding] 755731011141 domain linker motif; other site 755731011142 Ligand-binding domain of uncharacterized DNA-binding regulatory proteins that are members of the LacI-GalR family of bacterial transcription repressors; Region: PBP1_LacI_like_1; cd06277 755731011143 putative dimerization interface [polypeptide binding]; other site 755731011144 putative ligand binding site [chemical binding]; other site 755731011145 Transcriptional regulators [Transcription]; Region: PurR; COG1609 755731011146 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 755731011147 DNA binding site [nucleotide binding] 755731011148 domain linker motif; other site 755731011149 Ligand-binding domain of uncharacterized DNA-binding regulatory proteins that are members of the LacI-GalR family of bacterial transcription repressors; Region: PBP1_LacI_like_1; cd06277 755731011150 putative dimerization interface [polypeptide binding]; other site 755731011151 putative ligand binding site [chemical binding]; other site 755731011152 Domain of unknown function (DUF377); Region: DUF377; pfam04041 755731011153 Glycosyl hydrolase families: GH43, GH62, GH32, GH68; Region: GH43_62_32_68; cl14647 755731011154 active site 755731011155 AGE domain; N-acyl-D-glucosamine 2-epimerase domain; Responsible for intermediate epimerization during biosynthesis of N-acetylneuraminic acid. Catalytic mechanism is believed to be via nucleotide elimination and readdition and is ATP modulated. AGE is...; Region: AGE; cl00183 755731011156 dimerization interface [polypeptide binding]; other site 755731011157 putative active cleft [active] 755731011158 Glycosyl hydrolase families: GH43, GH62, GH32, GH68; Region: GH43_62_32_68; cl14647 755731011159 active site 755731011160 Acetyl xylan esterase (AXE1); Region: AXE1; pfam05448 755731011161 Putative lysophospholipase; Region: Hydrolase_4; pfam12146 755731011162 TIGR03943 family protein; Region: TIGR03943 755731011163 The Fer4_NifH superfamily contains a variety of proteins which share a common ATP-binding domain. Functionally, proteins in this superfamily use the energy from hydrolysis of NTP to transfer electron or ion; Region: Fer4_NifH; cl17203 755731011164 Predicted permeases [General function prediction only]; Region: COG0701 755731011165 The Fer4_NifH superfamily contains a variety of proteins which share a common ATP-binding domain. Functionally, proteins in this superfamily use the energy from hydrolysis of NTP to transfer electron or ion; Region: Fer4_NifH; cl17203 755731011166 Cobalamin synthesis protein cobW C-terminal domain; Region: CobW_C; pfam07683 755731011167 Ferric uptake regulator(Fur) and related metalloregulatory proteins; typically iron-dependent, DNA-binding repressors and activators; Region: Fur_like; cd07153 755731011168 metal binding site 2 [ion binding]; metal-binding site 755731011169 putative DNA binding helix; other site 755731011170 metal binding site 1 [ion binding]; metal-binding site 755731011171 dimer interface [polypeptide binding]; other site 755731011172 structural Zn2+ binding site [ion binding]; other site 755731011173 Acetyltransferases, including N-acetylases of ribosomal proteins [Translation, ribosomal structure and biogenesis]; Region: RimL; COG1670 755731011174 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 755731011175 Coenzyme A binding pocket [chemical binding]; other site 755731011176 CarD-like/TRCF domain; Region: CarD_CdnL_TRCF; pfam02559 755731011177 CarD-like/TRCF domain; Region: CarD_CdnL_TRCF; cl00588 755731011178 Nitrilase superfamily, including nitrile- or amide-hydrolyzing enzymes and amide-condensing enzymes; Region: nitrilase; cd07197 755731011179 Predicted amidohydrolase [General function prediction only]; Region: COG0388 755731011180 active site 755731011181 catalytic triad [active] 755731011182 dimer interface [polypeptide binding]; other site 755731011183 Uncharacterized protein containing a NRPS condensation (elongation) domain [General function prediction only]; Region: COG4908 755731011184 AMP-binding domain protein; Validated; Region: PRK08315 755731011185 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 755731011186 Uncharacterized subfamily of fatty acid CoA ligase (FACL); Region: FACL_like_2; cd05917 755731011187 acyl-activating enzyme (AAE) consensus motif; other site 755731011188 acyl-activating enzyme (AAE) consensus motif; other site 755731011189 putative AMP binding site [chemical binding]; other site 755731011190 putative active site [active] 755731011191 putative CoA binding site [chemical binding]; other site 755731011192 FMN-binding domain; Region: FMN_bind; cl01081 755731011193 Membrane-associated lipoprotein involved in thiamine biosynthesis [Coenzyme metabolism]; Region: ApbE; COG1477 755731011194 ApbE family; Region: ApbE; pfam02424 755731011195 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 755731011196 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 755731011197 Spore germination protein; Region: Spore_permease; cl17796 755731011198 germination protein, Ger(x)C family; Region: spore_ger_x_C; TIGR02887 755731011199 Spore germination B3/ GerAC like, C-terminal; Region: Spore_GerAC; pfam05504 755731011200 Bacillus/Clostridium GerA spore germination protein; Region: GerA; pfam03323 755731011201 cyclophilin: cyclophilin-type peptidylprolyl cis- trans isomerases. This family contains eukaryotic, bacterial and archeal proteins which exhibit a peptidylprolyl cis- trans isomerases activity (PPIase, Rotamase) and in addition bind the...; Region: cyclophilin; cd00317 755731011202 active site 755731011203 A predicted NlpC/p60-like peptidase; Region: BtrH; pfam14399 755731011204 D-alanyl-D-alanine carboxypeptidase; Region: VanY; pfam02557 755731011205 Putative peptidoglycan binding domain; Region: PG_binding_1; pfam01471 755731011206 Uncharacterized protein conserved in bacteria (DUF2313); Region: DUF2313; cl01542 755731011207 Uncharacterized homolog of phage Mu protein gp47 [Function unknown]; Region: XkdT; COG3299 755731011208 Protein of unknown function (DUF2634); Region: DUF2634; pfam10934 755731011209 Protein of unknown function (DUF2577); Region: DUF2577; pfam10844 755731011210 Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118 755731011211 Phage XkdN-like protein; Region: XkdN; pfam08890 755731011212 Protein of unknown function (DUF2001); Region: DUF2001; pfam09393 755731011213 Phage tail sheath protein; Region: Phage_sheath_1; pfam04984 755731011214 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 755731011215 non-specific DNA binding site [nucleotide binding]; other site 755731011216 salt bridge; other site 755731011217 sequence-specific DNA binding site [nucleotide binding]; other site 755731011218 hypothetical protein; Provisional; Region: PRK05807 755731011219 S1_RPS1_repeat_hs4: Ribosomal protein S1 (RPS1) domain. RPS1 is a component of the small ribosomal subunit thought to be involved in the recognition and binding of mRNA's during translation initiation. The bacterial RPS1 domain architecture consists...; Region: S1_RPS1_repeat_hs4; cd05692 755731011220 RNA binding site [nucleotide binding]; other site 755731011221 Septum formation initiator; Region: DivIC; pfam04977 755731011222 Spore cortex protein YabQ (Spore_YabQ); Region: Spore_YabQ; pfam09578 755731011223 YabP family; Region: YabP; cl06766 755731011224 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 755731011225 RNA binding surface [nucleotide binding]; other site 755731011226 Integration host factor (IHF) and HU are small heterodimeric members of the DNABII protein family that bind and bend DNA, functioning as architectural factors in many cellular processes including transcription, site-specific recombination, and...; Region: HU_IHF; cd00591 755731011227 IHF dimer interface [polypeptide binding]; other site 755731011228 IHF - DNA interface [nucleotide binding]; other site 755731011229 nucleoside triphosphate pyrophosphohydrolase; Reviewed; Region: mazG; PRK09562 755731011230 Nucleoside Triphosphate Pyrophosphohydrolase (EC 3.6.1.8) N-terminal tandem-domain of MazG proteins from Escherichia coli and bacterial homologs; Region: NTP-PPase_MazG_Nterm; cd11528 755731011231 homodimer interface [polypeptide binding]; other site 755731011232 metal binding site [ion binding]; metal-binding site 755731011233 Nucleoside Triphosphate Pyrophosphohydrolase (EC 3.6.1.8) C-terminal tandem-domain of MazG proteins from Escherichia coli and bacterial homologs' Region: NTP-PPase_MazG_Cterm; cd11529 755731011234 homodimer interface [polypeptide binding]; other site 755731011235 active site 755731011236 putative chemical substrate binding site [chemical binding]; other site 755731011237 metal binding site [ion binding]; metal-binding site 755731011238 Single-stranded DNA-binding protein [DNA replication, recombination, and repair]; Region: Ssb; COG0629 755731011239 SSB_OBF: A subfamily of OB folds similar to the OB fold of ssDNA-binding protein (SSB). SSBs bind with high affinity to ssDNA. They bind to and protect ssDNA intermediates during DNA metabolic pathways. All bacterial and eukaryotic SSBs studied to date...; Region: SSB_OBF; cd04496 755731011240 dimer interface [polypeptide binding]; other site 755731011241 ssDNA binding site [nucleotide binding]; other site 755731011242 tetramer (dimer of dimers) interface [polypeptide binding]; other site 755731011243 stage V sporulation protein T; Region: spore_V_T; TIGR02851 755731011244 looped-hinge helix DNA binding domain, AbrB family; Region: lp_hng_hel_AbrB; TIGR01439 755731011245 peptidylprolyl isomerase; Provisional; Region: prsA; PRK00059 755731011246 PPIC-type PPIASE domain; Region: Rotamase; pfam00639 755731011247 Transcription-repair coupling factor (superfamily II helicase) [DNA replication, recombination, and repair / Transcription]; Region: Mfd; COG1197 755731011248 CarD-like/TRCF domain; Region: CarD_TRCF; smart01058 755731011249 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 755731011250 ATP binding site [chemical binding]; other site 755731011251 putative Mg++ binding site [ion binding]; other site 755731011252 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 755731011253 nucleotide binding region [chemical binding]; other site 755731011254 ATP-binding site [chemical binding]; other site 755731011255 TRCF domain; Region: TRCF; pfam03461 755731011256 Peptidyl-tRNA hydrolase (PTH) is a monomeric protein that cleaves the ester bond linking the nascent peptide and tRNA when peptidyl-tRNA is released prematurely from the ribosome. This ensures the recycling of peptidyl-tRNAs into tRNAs produced through...; Region: PTH; cd00462 755731011257 putative active site [active] 755731011258 catalytic residue [active] 755731011259 ribose-phosphate pyrophosphokinase; Provisional; Region: PRK01259 755731011260 N-terminal domain of ribose phosphate pyrophosphokinase; Region: Pribosyltran_N; pfam13793 755731011261 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 755731011262 active site 755731011263 UDP-N-acetylglucosamine diphosphorylase/glucosamine-1-phosphate N-acetyltransferase; Region: glmU; TIGR01173 755731011264 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394 755731011265 N-acetyl-glucosamine-1-phosphate uridyltransferase (GlmU), C-terminal left-handed beta-helix (LbH) acetyltransferase domain: GlmU is also known as UDP-N-acetylglucosamine pyrophosphorylase. It is a bifunctional bacterial enzyme that catalyzes two...; Region: LbH_GlmU_C; cd03353 755731011266 active site 755731011267 substrate binding site [chemical binding]; other site 755731011268 CoA binding site [chemical binding]; other site 755731011269 regulatory protein SpoVG; Reviewed; Region: PRK13259 755731011270 pur operon repressor; Provisional; Region: PRK09213 755731011271 Bacterial purine repressor, N-terminal; Region: PuR_N; pfam09182 755731011272 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 755731011273 active site 755731011274 UDP-N-acetylmuramate--L-alanine ligase; Provisional; Region: murC; PRK00421 755731011275 Mur ligase family, catalytic domain; Region: Mur_ligase; pfam01225 755731011276 Mur ligase middle domain; Region: Mur_ligase_M; pfam08245 755731011277 Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875 755731011278 FabZ is a 17kD beta-hydroxyacyl-acyl carrier protein (ACP) dehydratase that primarily catalyzes the dehydration of beta-hydroxyacyl-ACP to trans-2-acyl-ACP, the third step in the elongation phase of the bacterial/ plastid, type II, fatty-acid...; Region: FabZ; cd01288 755731011279 Predicted periplasmic protein (DUF2233); Region: DUF2233; pfam09992 755731011280 Rod binding protein; Region: Rod-binding; cl01626 755731011281 Flagellar basal body rod protein [Cell motility and secretion]; Region: FlgG; COG4786 755731011282 Flagella basal body rod protein; Region: Flg_bb_rod; pfam00460 755731011283 Flagellar basal body rod FlgEFG protein C-terminal; Region: Flg_bbr_C; pfam06429 755731011284 Flagellar basal body rod protein [Cell motility and secretion]; Region: FlgG; COG4786 755731011285 Flagella basal body rod protein; Region: Flg_bb_rod; pfam00460 755731011286 flagellar basal-body rod protein FlgF; Region: flgF; TIGR02490 755731011287 rod shape-determining protein Mbl; Provisional; Region: PRK13928 755731011288 MreB and similar proteins; Region: MreB_like; cd10225 755731011289 nucleotide binding site [chemical binding]; other site 755731011290 Mg binding site [ion binding]; other site 755731011291 putative protofilament interaction site [polypeptide binding]; other site 755731011292 RodZ interaction site [polypeptide binding]; other site 755731011293 [FeFe] hydrogenase H-cluster maturation GTPase HydF; Region: GTP_HydF; TIGR03918 755731011294 E. coli Ras-like protein (Era)-like GTPase; Region: Era_like; cd00880 755731011295 G1 box; other site 755731011296 GTP/Mg2+ binding site [chemical binding]; other site 755731011297 Switch I region; other site 755731011298 G2 box; other site 755731011299 Switch II region; other site 755731011300 G3 box; other site 755731011301 G4 box; other site 755731011302 G5 box; other site 755731011303 [FeFe] hydrogenase H-cluster radical SAM maturase HydG; Region: rSAM_HydG; TIGR03955 755731011304 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cl15377 755731011305 FeS/SAM binding site; other site 755731011306 Biotin and Thiamin Synthesis associated domain; Region: BATS; smart00876 755731011307 putative iron-only hydrogenase system regulator; Region: hyd_TM1266; TIGR03959 755731011308 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3666 755731011309 Transposase DDE domain; Region: DDE_Tnp_1_6; pfam13751 755731011310 Kef-type K+ transport systems, membrane components [Inorganic ion transport and metabolism]; Region: KefB; COG0475 755731011311 Sodium/hydrogen exchanger family; Region: Na_H_Exchanger; pfam00999 755731011312 Putative regulatory, ligand-binding protein related to C-terminal domains of K+ channels [Inorganic ion transport and metabolism]; Region: COG0490 755731011313 TrkA-C domain; Region: TrkA_C; pfam02080 755731011314 Peptidase M60-like family; Region: M60-like; pfam13402 755731011315 Stage III sporulation protein D; Region: SpoIIID; pfam12116 755731011316 probable dihydroxyacetone kinase regulator; Region: DHAK_reg; TIGR02366 755731011317 This family includes the Gtfs, a group of homologous glycosyltransferases involved in the final stages of the biosynthesis of antibiotics vancomycin and related chloroeremomycin. Gtfs transfer sugar moieties from an activated NDP-sugar donor to the...; Region: GT1_Gtf_like; cd03784 755731011318 glycosyltransferase, MGT family; Region: MGT; TIGR01426 755731011319 active site 755731011320 TDP-binding site; other site 755731011321 acceptor substrate-binding pocket; other site 755731011322 homodimer interface [polypeptide binding]; other site 755731011323 Orthopoxvirus protein of unknown function (DUF830); Region: DUF830; cl13998 755731011324 seryl-tRNA synthetase; Provisional; Region: PRK05431 755731011325 Seryl-tRNA synthetase N-terminal domain; Region: Seryl_tRNA_N; pfam02403 755731011326 Class II tRNA amino-acyl synthetase-like catalytic core domain. Class II amino acyl-tRNA synthetases (aaRS) share a common fold and generally attach an amino acid to the 3' OH of ribose of the appropriate tRNA. PheRS is an exception in that it...; Region: class_II_aaRS-like_core; cl00268 755731011327 motif 1; other site 755731011328 dimer interface [polypeptide binding]; other site 755731011329 active site 755731011330 motif 2; other site 755731011331 motif 3; other site 755731011332 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cl17215 755731011333 Bifunctional PLP-dependent enzyme with beta-cystathionase and maltose regulon repressor activities [Amino acid transport and metabolism]; Region: MalY; COG1168 755731011334 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 755731011335 pyridoxal 5'-phosphate binding site [chemical binding]; other site 755731011336 homodimer interface [polypeptide binding]; other site 755731011337 catalytic residue [active] 755731011338 Cysteine synthase [Amino acid transport and metabolism]; Region: CysK; COG0031 755731011339 CBS_like: This subgroup includes Cystathionine beta-synthase (CBS) and Cysteine synthase. CBS is a unique heme-containing enzyme that catalyzes a pyridoxal 5'-phosphate (PLP)-dependent condensation of serine and homocysteine to give cystathionine; Region: CBS_like; cd01561 755731011340 dimer interface [polypeptide binding]; other site 755731011341 pyridoxal 5'-phosphate binding site [chemical binding]; other site 755731011342 catalytic residue [active] 755731011343 DNA / pantothenate metabolism flavoprotein; Region: DFP; cl04410 755731011344 phosphopantothenoylcysteine decarboxylase; Validated; Region: PRK07313 755731011345 Flavoprotein; Region: Flavoprotein; pfam02441 755731011346 [FeFe] hydrogenase H-cluster radical SAM maturase HydE; Region: rSAM_HydE; TIGR03956 755731011347 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 755731011348 FeS/SAM binding site; other site 755731011349 Biotin and Thiamin Synthesis associated domain; Region: BATS; cl06149 755731011350 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG2963 755731011351 Helix-turn-helix domain; Region: HTH_28; pfam13518 755731011352 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG2963 755731011353 Transposase; Region: HTH_Tnp_1; cl17663 755731011354 Helix-turn-helix domain; Region: HTH_28; pfam13518 755731011355 HTH-like domain; Region: HTH_21; pfam13276 755731011356 Integrase core domain; Region: rve; pfam00665 755731011357 Integrase core domain; Region: rve_2; pfam13333 755731011358 Pleckstrin homology (PH)-like domains in bacteria (PHb); Region: PH-like_bacteria; cd13225 755731011359 pentamer interface [polypeptide binding]; other site 755731011360 dodecaamer interface [polypeptide binding]; other site 755731011361 Sugar kinases, ribokinase family [Carbohydrate transport and metabolism]; Region: RbsK; COG0524 755731011362 2-keto-3-deoxygluconate kinase (KdgK) phosphorylates 2-keto-3-deoxygluconate (KDG) to form 2-keto-3-deoxy-6-phosphogluconate (KDGP). KDG is the common intermediate product, that allows organisms to channel D-glucuronate and/or D-galacturinate into the...; Region: KdgK; cd01166 755731011363 substrate binding site [chemical binding]; other site 755731011364 ATP binding site [chemical binding]; other site 755731011365 2-keto-3-deoxy-6-phosphogluconate aldolase [Carbohydrate transport and metabolism]; Region: Eda; COG0800 755731011366 KDPG and KHG aldolase; Region: KDPG_aldolase; cd00452 755731011367 active site 755731011368 intersubunit interface [polypeptide binding]; other site 755731011369 catalytic residue [active] 755731011370 phosphonate utilization associated transcriptional regulator; Region: phnR_burk; TIGR03338 755731011371 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 755731011372 DNA-binding site [nucleotide binding]; DNA binding site 755731011373 FCD domain; Region: FCD; pfam07729 755731011374 Iron-containing alcohol dehydrogenases-like; Region: Fe-ADH1; cd08185 755731011375 Iron-containing alcohol dehydrogenase; Region: Fe-ADH; pfam00465 755731011376 putative active site [active] 755731011377 metal binding site [ion binding]; metal-binding site 755731011378 bifunctional acetaldehyde-CoA/alcohol dehydrogenase; Provisional; Region: PRK13805 755731011379 Coenzyme A acylating aldehyde dehydrogenase (ACDH), ALDH family 20-like; Region: ALDH_F20_ACDH; cd07122 755731011380 putative catalytic cysteine [active] 755731011381 C-terminal alcohol dehydrogenase domain of the acetaldehyde dehydrogenase-alcohol dehydrogenase bifunctional two-domain protein (AAD); Region: AAD_C; cd08178 755731011382 putative active site [active] 755731011383 metal binding site [ion binding]; metal-binding site 755731011384 methyltransferase cognate corrinoid proteins, Methanosarcina family; Region: pyl_corrinoid; TIGR02370 755731011385 B12 binding domain of corrinoid proteins. A family of small methanogenic corrinoid proteins that bind methyl-Co(III) 5-hydroxybenzimidazolylcobamide as a cofactor. They play a role on the methanogenesis from trimethylamine, dimethylamine or...; Region: corrinoid_protein_B12-BD; cd02070 755731011386 B12 binding site [chemical binding]; other site 755731011387 cobalt ligand [ion binding]; other site 755731011388 Protein of unknown function (DUF1638); Region: DUF1638; pfam07796 755731011389 2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207 755731011390 Uncharacterized metal-binding protein [General function prediction only]; Region: COG3894 755731011391 catalytic loop [active] 755731011392 iron binding site [ion binding]; other site 755731011393 ABC-type cobalamin/Fe3+-siderophores transport systems, ATPase components [Inorganic ion transport and metabolism / Coenzyme metabolism]; Region: FepC; COG1120 755731011394 ATP-binding component of iron-siderophores, vitamin B12 and hemin transporters and related proteins; Region: ABC_Iron-Siderophores_B12_Hemin; cd03214 755731011395 Walker A/P-loop; other site 755731011396 ATP binding site [chemical binding]; other site 755731011397 Q-loop/lid; other site 755731011398 ABC transporter signature motif; other site 755731011399 Walker B; other site 755731011400 D-loop; other site 755731011401 H-loop/switch region; other site 755731011402 iron-hydroxamate transporter permease subunit; Provisional; Region: PRK10577 755731011403 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550 755731011404 ABC-ATPase subunit interface; other site 755731011405 dimer interface [polypeptide binding]; other site 755731011406 putative PBP binding regions; other site 755731011407 ABC-type Fe3+-hydroxamate transport system, periplasmic component [Inorganic ion transport and metabolism]; Region: FepB; COG0614 755731011408 Helical backbone metal receptor (TroA-like domain). These proteins have been shown to function in the ABC transport of ferric siderophores and metal ions such as Mn2+, Fe3+, Cu2+ and/or Zn2+. Their ligand binding site is formed in the interface between...; Region: TroA-like; cl00262 755731011409 intersubunit interface [polypeptide binding]; other site 755731011410 phosphopentomutase; Provisional; Region: PRK05362 755731011411 Metalloenzyme superfamily; Region: Metalloenzyme; pfam01676 755731011412 Bacterial capsule synthesis protein PGA_cap; Region: PGA_cap; smart00854 755731011413 CapA and related proteins, metallophosphatase domain; Region: MPP_CapA; cd07381 755731011414 putative active site [active] 755731011415 putative metal binding site [ion binding]; other site 755731011416 Sulfatase; Region: Sulfatase; cl17466 755731011417 37-kD nucleoid-associated bacterial protein; Region: NA37; pfam04245 755731011418 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 755731011419 TPR motif; other site 755731011420 binding surface 755731011421 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 755731011422 binding surface 755731011423 Tetratricopeptide repeat; Region: TPR_12; pfam13424 755731011424 TPR motif; other site 755731011425 TPR repeat; Region: TPR_11; pfam13414 755731011426 SGNH_hydrolase, or GDSL_hydrolase, is a diverse family of lipases and esterases. The tertiary fold of the enzyme is substantially different from that of the alpha/beta hydrolase family and unique among all known hydrolases; its active site closely...; Region: SGNH_hydrolase; cd00229 755731011427 active site 755731011428 catalytic triad [active] 755731011429 oxyanion hole [active] 755731011430 Domain of unknown function (DUF1836); Region: DUF1836; pfam08876 755731011431 putative sporulation protein YtaF; Region: spore_YtaF; TIGR02840 755731011432 Domain of unknown function DUF; Region: DUF204; pfam02659 755731011433 anthranilate synthase component I, non-proteobacterial lineages; Region: trpE_most; TIGR00564 755731011434 Anthranilate synthase component I, N terminal region; Region: Anth_synt_I_N; pfam04715 755731011435 chorismate binding enzyme; Region: Chorismate_bind; pfam00425 755731011436 para-aminobenzoate synthase component II; Provisional; Region: PRK08857 755731011437 Type 1 glutamine amidotransferase (GATase1) domain found in Anthranilate synthase; Region: GATase1_Anthranilate_Synthase; cd01743 755731011438 glutamine binding [chemical binding]; other site 755731011439 catalytic triad [active] 755731011440 anthranilate phosphoribosyltransferase; Provisional; Region: trpD; PRK00188 755731011441 Glycosyl transferase family, helical bundle domain; Region: Glycos_trans_3N; pfam02885 755731011442 Glycosyl transferase family, a/b domain; Region: Glycos_transf_3; pfam00591 755731011443 Indole-3-glycerol phosphate synthase (IGPS); an enzyme in the tryptophan biosynthetic pathway, catalyzing the ring closure reaction of 1-(o-carboxyphenylamino)-1-deoxyribulose-5-phosphate (CdRP) to indole-3-glycerol phosphate (IGP), accompanied by the...; Region: IGPS; cd00331 755731011444 active site 755731011445 ribulose/triose binding site [chemical binding]; other site 755731011446 phosphate binding site [ion binding]; other site 755731011447 substrate (anthranilate) binding pocket [chemical binding]; other site 755731011448 product (indole) binding pocket [chemical binding]; other site 755731011449 Phosphoribosylanthranilate isomerase (PRAI) catalyzes the fourth step of the tryptophan biosynthesis, the conversion of N-(5'- phosphoribosyl)-anthranilate (PRA) to 1-(o-carboxyphenylamino)- 1-deoxyribulose 5-phosphate (CdRP). Most PRAIs are...; Region: PRAI; cd00405 755731011450 active site 755731011451 tryptophan synthase, beta subunit; Region: trpB; TIGR00263 755731011452 Tryptophan synthase-beta: Trptophan synthase is a bifunctional enzyme that catalyses the last two steps in the biosynthesis of L-tryptophan via its alpha and beta reactions. In the alpha reaction, indole 3-glycerol phosphate is cleaved reversibly to...; Region: Trp-synth_B; cd06446 755731011453 pyridoxal 5'-phosphate binding site [chemical binding]; other site 755731011454 catalytic residue [active] 755731011455 tryptophan synthase alpha subunit; Provisional; Region: trpA; CHL00200 755731011456 Ttryptophan synthase (TRPS) alpha subunit (TSA). TPRS is a bifunctional tetrameric enzyme (2 alpha and 2 beta subunits) that catalyzes the last two steps of L-tryptophan biosynthesis. Alpha and beta subunit catalyze two distinct reactions which are both...; Region: Tryptophan_synthase_alpha; cd04724 755731011457 substrate binding site [chemical binding]; other site 755731011458 active site 755731011459 catalytic residues [active] 755731011460 heterodimer interface [polypeptide binding]; other site 755731011461 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 755731011462 Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013 755731011463 Methyltransferase domain; Region: Methyltransf_23; pfam13489 755731011464 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 755731011465 S-adenosylmethionine binding site [chemical binding]; other site 755731011466 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 755731011467 S-adenosylmethionine binding site [chemical binding]; other site 755731011468 Glycosyltransferases involved in cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WcaA; COG0463 755731011469 UDP-glucose LOS-beta-1,4 glucosyltransferase is required for biosynthesis of lipooligosaccharide; Region: Beta4Glucosyltransferase; cd02511 755731011470 putative metal binding site; other site 755731011471 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 755731011472 binding surface 755731011473 TPR motif; other site 755731011474 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cl02429 755731011475 binding surface 755731011476 TPR motif; other site 755731011477 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 755731011478 Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248 755731011479 active site 755731011480 catalytic tetrad [active] 755731011481 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cl17037 755731011482 hexokinase; Provisional; Region: PTZ00107 755731011483 Hexokinase; Region: Hexokinase_2; pfam03727 755731011484 N-acetylmuramoyl-L-alanine amidase [Cell envelope biogenesis, outer membrane]; Region: AmiC; COG0860 755731011485 N-acetylmuramoyl-L-alanine amidase or MurNAc-LAA (also known as peptidoglycan aminohydrolase, NAMLA amidase, NAMLAA, Amidase 3, and peptidoglycan amidase; EC 3.5.1.28) is an autolysin that hydrolyzes the amide bond between N-acetylmuramoyl and L-amino...; Region: MurNAc-LAA; cd02696 755731011486 active site 755731011487 metal binding site [ion binding]; metal-binding site 755731011488 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 755731011489 dimerization interface [polypeptide binding]; other site 755731011490 Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer); Region: MA; smart00283 755731011491 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 755731011492 dimer interface [polypeptide binding]; other site 755731011493 putative CheW interface [polypeptide binding]; other site 755731011494 RNA polymerase factor sigma-70; Validated; Region: PRK06811 755731011495 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 755731011496 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 755731011497 DNA binding residues [nucleotide binding] 755731011498 Guanosine polyphosphate pyrophosphohydrolases/synthetases [Signal transduction mechanisms / Transcription]; Region: SpoT; COG0317 755731011499 Nucleotidyltransferase (NT) domain of RelA- and SpoT-like ppGpp synthetases and hydrolases; Region: NT_Rel-Spo_like; cd05399 755731011500 synthetase active site [active] 755731011501 NTP binding site [chemical binding]; other site 755731011502 metal binding site [ion binding]; metal-binding site 755731011503 Putative zinc ribbon domain; Region: Zn_ribbon_2; pfam12674 755731011504 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 755731011505 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 755731011506 Putative lysophospholipase; Region: Hydrolase_4; pfam12146 755731011507 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 755731011508 Prolyl oligopeptidase family; Region: Peptidase_S9; pfam00326 755731011509 ATPase components of ABC transporters with duplicated ATPase domains [General function prediction only]; Region: Uup; COG0488 755731011510 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 755731011511 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 755731011512 Family 4 Uracil-DNA glycosylase (UDG), found exclusively in thermophilic organisms; Region: UDG_F4_TTUDGA_like; cd10030 755731011513 Fe-S cluster binding site [ion binding]; other site 755731011514 active site 755731011515 BioY family; Region: BioY; pfam02632 755731011516 Putative protein-S-isoprenylcysteine methyltransferase [Posttranslational modification, protein turnover, chaperones]; Region: STE14; COG2020 755731011517 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 755731011518 dimerization interface [polypeptide binding]; other site 755731011519 Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer); Region: MA; smart00283 755731011520 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 755731011521 dimer interface [polypeptide binding]; other site 755731011522 putative CheW interface [polypeptide binding]; other site 755731011523 Endoplasmic reticulum-based factor for assembly of V-ATPase; Region: Vma12; pfam11712 755731011524 DinB superfamily; Region: DinB_2; pfam12867 755731011525 RNA polymerase factor sigma-70; Validated; Region: PRK08295 755731011526 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 755731011527 Sigma-70, region 4; Region: Sigma70_r4_2; pfam08281 755731011528 rRNA methylases [Translation, ribosomal structure and biogenesis]; Region: SpoU; COG0566 755731011529 RNA 2'-O ribose methyltransferase substrate binding; Region: SpoU_sub_bind; smart00967 755731011530 SpoU rRNA Methylase family; Region: SpoU_methylase; pfam00588 755731011531 RIBOc. Ribonuclease III C terminal domain. This group consists of eukaryotic, bacterial and archeal ribonuclease III (RNAse III) proteins. RNAse III is a double stranded RNA-specific endonuclease. Prokaryotic RNAse III is important in...; Region: RIBOc; cd00593 755731011532 active site 755731011533 metal binding site [ion binding]; metal-binding site 755731011534 dimerization interface [polypeptide binding]; other site 755731011535 Human Ape1-like subfamily of the ExoIII family purinic/apyrimidinic (AP) endonucleases; Region: Ape1-like_AP-endo; cd09087 755731011536 active site 755731011537 putative catalytic site [active] 755731011538 DNA binding site [nucleotide binding] 755731011539 putative phosphate binding site [ion binding]; other site 755731011540 metal binding site A [ion binding]; metal-binding site 755731011541 AP binding site [nucleotide binding]; other site 755731011542 metal binding site B [ion binding]; metal-binding site 755731011543 Cell wall-associated hydrolases (invasion-associated proteins) [Cell envelope biogenesis, outer membrane]; Region: Spr; COG0791 755731011544 NlpC/P60 family; Region: NLPC_P60; cl17555 755731011545 Bacterial SH3 domain; Region: SH3_3; cl17532 755731011546 cysteinyl-tRNA synthetase; Validated; Region: cysS; PRK00260 755731011547 catalytic core domain of cysteinyl tRNA synthetase; Region: CysRS_core; cd00672 755731011548 active site 755731011549 HIGH motif; other site 755731011550 catalytic core domain of cysteinyl tRNA synthetase; Region: CysRS_core; cd00672 755731011551 KMSKS motif; other site 755731011552 Anticodon-binding domain of class Ia aminoacyl tRNA synthetases and similar domains; Region: Anticodon_Ia_like; cl12020 755731011553 Serine acetyltransferase, N-terminal; Region: SATase_N; cl05762 755731011554 serine O-acetyltransferase; Region: cysE; TIGR01172 755731011555 Serine acetyltransferase (SAT): SAT catalyzes the CoA-dependent acetylation of the side chain hydroxyl group of L-serine to form O-acetylserine, as the first step of a two-step biosynthetic pathway in bacteria and plants leading to the formation of...; Region: LbH_SAT; cd03354 755731011556 trimer interface [polypeptide binding]; other site 755731011557 active site 755731011558 substrate binding site [chemical binding]; other site 755731011559 CoA binding site [chemical binding]; other site 755731011560 FOG: FHA domain [Signal transduction mechanisms]; Region: COG1716 755731011561 Protein of unknown function (DUF3343); Region: DUF3343; pfam11823 755731011562 8-oxoguanine DNA glycosylase, N-terminal domain; Region: OGG_N; pfam07934 755731011563 8-oxoguanine DNA-glycosylase (ogg); Region: ogg; TIGR00588 755731011564 endonuclease III; includes endonuclease III (DNA-(apurinic or apyrimidinic site) lyase), alkylbase DNA glycosidases (Alka-family) and other DNA glycosidases; Region: ENDO3c; cd00056 755731011565 minor groove reading motif; other site 755731011566 helix-hairpin-helix signature motif; other site 755731011567 substrate binding pocket [chemical binding]; other site 755731011568 active site 755731011569 Homoserine O-succinyltransferase; Region: HTS; pfam04204 755731011570 Type 1 glutamine amidotransferase (GATase1)-like domain found in homoserine trans-succinylase (HTS); Region: GATase1_HTS; cd03131 755731011571 proposed active site lysine [active] 755731011572 conserved cys residue [active] 755731011573 O-acetylhomoserine sulfhydrylase [Amino acid transport and metabolism]; Region: MET17; COG2873 755731011574 CGS_like: Cystathionine gamma-synthase is a PLP dependent enzyme and catalyzes the committed step of methionine biosynthesis. This pathway is unique to microorganisms and plants, rendering the enzyme an attractive target for the development of...; Region: CGS_like; cd00614 755731011575 homodimer interface [polypeptide binding]; other site 755731011576 substrate-cofactor binding pocket; other site 755731011577 pyridoxal 5'-phosphate binding site [chemical binding]; other site 755731011578 catalytic residue [active] 755731011579 Spore germination protein; Region: Spore_permease; cl17796 755731011580 germination protein, Ger(x)C family; Region: spore_ger_x_C; TIGR02887 755731011581 Spore germination B3/ GerAC like, C-terminal; Region: Spore_GerAC; pfam05504 755731011582 Bacillus/Clostridium GerA spore germination protein; Region: GerA; pfam03323 755731011583 Uncharacterized oxidoreductases, Fe-dependent alcohol dehydrogenase family [Energy production and conversion]; Region: COG1979 755731011584 Butanol dehydrogenase catalyzes the conversion of butyraldehyde to butanol with the cofactor NAD(P)H being oxidized in the process; Region: BDH; cd08187 755731011585 dimer interface [polypeptide binding]; other site 755731011586 active site 755731011587 metal binding site [ion binding]; metal-binding site 755731011588 Predicted transcriptional regulators [Transcription]; Region: SoxR; COG0789 755731011589 Helix-Turn-Helix DNA binding domain of the MerR-like transcription regulators YyaN and YraB; Region: HTH_YyaN; cd01109 755731011590 DNA binding residues [nucleotide binding] 755731011591 putative dimer interface [polypeptide binding]; other site 755731011592 Response regulator receiver domain; Region: Response_reg; pfam00072 755731011593 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 755731011594 active site 755731011595 phosphorylation site [posttranslational modification] 755731011596 intermolecular recognition site; other site 755731011597 dimerization interface [polypeptide binding]; other site 755731011598 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 755731011599 binding surface 755731011600 Tetratricopeptide repeat; Region: TPR_16; pfam13432 755731011601 TPR motif; other site 755731011602 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 755731011603 dimerization interface [polypeptide binding]; other site 755731011604 phosphate regulon sensor kinase PhoR; Region: phoR_proteo; TIGR02966 755731011605 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 755731011606 putative active site [active] 755731011607 heme pocket [chemical binding]; other site 755731011608 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 755731011609 dimer interface [polypeptide binding]; other site 755731011610 phosphorylation site [posttranslational modification] 755731011611 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 755731011612 ATP binding site [chemical binding]; other site 755731011613 Mg2+ binding site [ion binding]; other site 755731011614 G-X-G motif; other site 755731011615 potassium-transporting ATPase subunit A; Provisional; Region: PRK05482 755731011616 potassium-transporting ATPase subunit B; Provisional; Region: PRK01122 755731011617 E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122 755731011618 Soluble P-type ATPase [General function prediction only]; Region: COG4087 755731011619 potassium-transporting ATPase subunit C; Provisional; Region: PRK13995 755731011620 Osmosensitive K+ channel histidine kinase [Signal transduction mechanisms]; Region: KdpD; COG2205 755731011621 Osmosensitive K+ channel His kinase sensor domain; Region: KdpD; pfam02702 755731011622 USP domain is located between the N-terminal sensor domain and C-terminal catalytic domain of this Osmosensitive K+ channel histidine kinase family. The family of KdpD sensor kinase proteins regulates the kdpFABC operon responsible for potassium...; Region: USP_OKCHK; cd01987 755731011623 Ligand Binding Site [chemical binding]; other site 755731011624 Asp23 family; Region: Asp23; pfam03780 755731011625 YtxC-like family; Region: YtxC; pfam08812 755731011626 Uncharacterized conserved protein [Function unknown]; Region: COG2155 755731011627 Small, acid-soluble spore proteins, alpha/beta type; Region: SASP; pfam00269 755731011628 Predicted permease, member of the PurR regulon [General function prediction only]; Region: yhhT; COG0628 755731011629 putative iron-only hydrogenase system regulator; Region: hyd_TM1266; TIGR03959 755731011630 flagellar operon protein TIGR03826; Region: YvyF 755731011631 PAP2_like proteins, a super-family of histidine phosphatases and vanadium haloperoxidases, includes type 2 phosphatidic acid phosphatase or lipid phosphate phosphatase (LPP), Glucose-6-phosphatase, Phosphatidylglycerophosphatase B and bacterial acid...; Region: PAP2_like; cl00474 755731011632 Membrane-associated phospholipid phosphatase [Lipid metabolism]; Region: PgpB; COG0671 755731011633 active site 755731011634 ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653 755731011635 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; pfam01547 755731011636 ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132 755731011637 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 755731011638 ATP-binding cassette domain of the bacterial lipid flippase and related proteins, subfamily C; Region: ABCC_MsbA; cd03251 755731011639 Walker A/P-loop; other site 755731011640 ATP binding site [chemical binding]; other site 755731011641 Q-loop/lid; other site 755731011642 ABC transporter signature motif; other site 755731011643 Walker B; other site 755731011644 D-loop; other site 755731011645 H-loop/switch region; other site 755731011646 Uncharacterized conserved protein [Function unknown]; Region: COG2461 755731011647 Family of unknown function (DUF438); Region: DUF438; pfam04282 755731011648 Hemerythrin-like domain; Region: Hr-like; cd12108 755731011649 Fe binding site [ion binding]; other site 755731011650 Domain of unknown function (DUF1858); Region: DUF1858; pfam08984 755731011651 Bacterial protein of unknown function (DUF951); Region: DUF951; pfam06107 755731011652 Small-conductance mechanosensitive channel [Cell envelope biogenesis, outer membrane]; Region: MscS; COG0668 755731011653 Mechanosensitive ion channel; Region: MS_channel; pfam00924 755731011654 Predicted glutamine amidotransferases [General function prediction only]; Region: COG2071 755731011655 Subgroup of proteins having the Type 1 glutamine amidotransferase (GATase1) domain; Region: GATase1_2; cd01745 755731011656 catalytic triad [active] 755731011657 Rubredoxin; nonheme iron binding domains containing a [Fe(SCys)4] center. Rubredoxins are small nonheme iron proteins. The iron atom is coordinated by four cysteine residues (Fe(S-Cys)4), but iron can also be replaced by cobalt, nickel or zinc. They are...; Region: rubredoxin; cd00730 755731011658 Rubredoxin; Region: Rubredoxin; pfam00301 755731011659 iron binding site [ion binding]; other site 755731011660 Protein of unknown function (DUF1256); Region: DUF1256; cl06087 755731011661 PAS domain S-box; Region: sensory_box; TIGR00229 755731011662 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cl02459 755731011663 Serine phosphatase RsbU, regulator of sigma subunit [Signal transduction mechanisms / Transcription]; Region: RsbU; COG2208 755731011664 Stage II sporulation protein E (SpoIIE); Region: SpoIIE; pfam07228 755731011665 Methionine Aminopeptidase 1. E.C. 3.4.11.18. Also known as methionyl aminopeptidase and Peptidase M. Catalyzes release of N-terminal amino acids, preferentially methionine, from peptides and arylamides; Region: MetAP1; cd01086 755731011666 active site 755731011667 Rat sarcoma (Ras)-like superfamily of small guanosine triphosphatases (GTPases); Region: Ras_like_GTPase; cd00882 755731011668 G1 box; other site 755731011669 GTP/Mg2+ binding site [chemical binding]; other site 755731011670 G2 box; other site 755731011671 Switch I region; other site 755731011672 G3 box; other site 755731011673 Switch II region; other site 755731011674 G4 box; other site 755731011675 G5 box; other site 755731011676 Predicted membrane protein [Function unknown]; Region: COG2860 755731011677 UPF0126 domain; Region: UPF0126; pfam03458 755731011678 UPF0126 domain; Region: UPF0126; pfam03458 755731011679 Zn finger protein HypA/HybF (possibly regulating hydrogenase expression) [General function prediction only]; Region: HybF; COG0375 755731011680 Hydrogenase expression/synthesis hypA family; Region: HypA; pfam01155 755731011681 NADH-quinone oxidoreductase, chain I; Region: NuoI; TIGR01971 755731011682 The HCP family of iron-sulfur proteins includes hybrid cluster protein (HCP), acetyl-CoA synthase (ACS), and carbon monoxide dehydrogenase (CODH), all of which contain [Fe4-S4] metal clusters at their active sites. These proteins have a conserved...; Region: HCP_like; cl14655 755731011683 Ni,Fe-hydrogenase III large subunit [Energy production and conversion]; Region: HycE; COG3261 755731011684 NADH dehydrogenase subunit D; Validated; Region: PRK06075; cl17338 755731011685 Respiratory-chain NADH dehydrogenase, 30 Kd subunit; Region: Complex1_30kDa; pfam00329 755731011686 Ni,Fe-hydrogenase III small subunit [Energy production and conversion]; Region: COG3260 755731011687 Formate hydrogenlyase subunit 4 [Energy production and conversion]; Region: HyfC; COG0650 755731011688 NADH dehydrogenase; Region: NADHdh; cl00469 755731011689 NADH:ubiquinone oxidoreductase subunit 5 (chain L)/Multisubunit Na+/H+ antiporter, MnhA subunit [Energy production and conversion / Inorganic ion transport and metabolism]; Region: NuoL; COG1009 755731011690 NADH-Ubiquinone/plastoquinone (complex I), various chains; Region: Oxidored_q1; pfam00361 755731011691 Predicted permease, member of the PurR regulon [General function prediction only]; Region: yhhT; cl00465 755731011692 Domain of unknown function DUF20; Region: UPF0118; pfam01594 755731011693 N5-glutamine S-adenosyl-L-methionine-dependent methyltransferase; Provisional; Region: PRK09328 755731011694 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 755731011695 S-adenosylmethionine binding site [chemical binding]; other site 755731011696 Protein of unknown function (DUF1385); Region: DUF1385; pfam07136 755731011697 50S ribosomal protein L31; Reviewed; Region: rpmE; PRK00019 755731011698 transcription termination factor Rho; Provisional; Region: PRK12678 755731011699 Rho termination factor, N-terminal domain; Region: Rho_N; pfam07498 755731011700 Rho_CSD: Rho protein cold-shock domain (CSD). Rho protein is a transcription termination factor in most bacteria. In bacteria, there are two distinct mechanisms for mRNA transcription termination. In intrinsic termination, RNA polymerase and nascent mRNA...; Region: Rho_CSD; cd04459 755731011701 RNA binding site [nucleotide binding]; other site 755731011702 Transcription termination factor rho is a bacterial ATP-dependent RNA/DNA helicase. It is a homohexamer. Each monomer consists of an N-terminal domain of the OB fold, which is responsible for binding to cysteine rich nucleotides. This alignment is of the...; Region: rho_factor; cd01128 755731011703 multimer interface [polypeptide binding]; other site 755731011704 Walker A motif; other site 755731011705 ATP binding site [chemical binding]; other site 755731011706 Walker B motif; other site 755731011707 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 755731011708 This domain superfamily is found in a variety of structurally related metalloproteins, including the type I extradiol dioxygenases, glyoxalase I and a group of antibiotic resistance proteins; Region: Glo_EDI_BRP_like; cd06587 755731011709 active site 755731011710 purine nucleoside phosphorylase; Reviewed; Region: deoD; PRK05819 755731011711 Uridine phosphorylase [Nucleotide transport and metabolism]; Region: Udp; COG2820 755731011712 Sulfatase; Region: Sulfatase; pfam00884 755731011713 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 755731011714 PAS domain; Region: PAS_9; pfam13426 755731011715 putative active site [active] 755731011716 heme pocket [chemical binding]; other site 755731011717 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 755731011718 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 755731011719 ATP binding site [chemical binding]; other site 755731011720 Mg2+ binding site [ion binding]; other site 755731011721 G-X-G motif; other site 755731011722 hypothetical protein; Provisional; Region: PRK03881 755731011723 The N-terminal domain, an extradiol dioxygenase class III subunit B-like domain, of unknown proteins containing a C-terminal AMMECR1 domain; Region: ED_3B_N_AMMECR1; cd07951 755731011724 AMMECR1; Region: AMMECR1; pfam01871 755731011725 arginine deiminase; Provisional; Region: PRK01388 755731011726 Bacterial flagellin N-terminal helical region; Region: Flagellin_N; pfam00669 755731011727 Bacterial flagellin C-terminal helical region; Region: Flagellin_C; pfam00700 755731011728 phosphate regulon sensor kinase PhoR; Region: phoR_proteo; TIGR02966 755731011729 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 755731011730 putative active site [active] 755731011731 heme pocket [chemical binding]; other site 755731011732 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 755731011733 dimer interface [polypeptide binding]; other site 755731011734 phosphorylation site [posttranslational modification] 755731011735 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 755731011736 ATP binding site [chemical binding]; other site 755731011737 Mg2+ binding site [ion binding]; other site 755731011738 G-X-G motif; other site 755731011739 Na+-driven multidrug efflux pump [Defense mechanisms]; Region: NorM; COG0534 755731011740 Subfamily of the multidrug and toxic compound extrusion (MATE)-like proteins similar to Bacillus subtilis yoeA; Region: MATE_yoeA_like; cd13138 755731011741 ABC-2 type transporter; Region: ABC2_membrane; pfam01061 755731011742 ABC-type multidrug transport system, permease component [Defense mechanisms]; Region: COG0842 755731011743 ABC-type Mn/Zn transport systems, ATPase component [Inorganic ion transport and metabolism]; Region: ZnuC; COG1121 755731011744 ATP-binding cassette domain of the drug resistance transporter and related proteins, subfamily A; Region: ABC_DR_subfamily_A; cd03230 755731011745 Walker A/P-loop; other site 755731011746 ATP binding site [chemical binding]; other site 755731011747 Q-loop/lid; other site 755731011748 ABC transporter signature motif; other site 755731011749 Walker B; other site 755731011750 D-loop; other site 755731011751 H-loop/switch region; other site 755731011752 Predicted transcriptional regulators [Transcription]; Region: SoxR; COG0789 755731011753 Helix-Turn-Helix DNA binding domain of transcription regulators from the MerR superfamily; Region: HTH_MerR-SF; cl02600 755731011754 DNA binding residues [nucleotide binding] 755731011755 Helix-Turn-Helix DNA binding domain of MerR-like transcription regulators; Region: HTH_MerR-like; cd00592 755731011756 MerR HTH family regulatory protein; Region: MerR_1; pfam13411 755731011757 DNA binding residues [nucleotide binding] 755731011758 dimer interface [polypeptide binding]; other site 755731011759 rRNA large subunit methyltransferase; Provisional; Region: PRK00103 755731011760 Metal-dependent hydrolases of the beta-lactamase superfamily I [General function prediction only]; Region: PhnP; COG1235 755731011761 Predicted Zn-dependent hydrolases of the beta-lactamase fold [General function prediction only]; Region: COG2220 755731011762 UDP-N-acetylglucosamine 1-carboxyvinyltransferase; Region: murA; TIGR01072 755731011763 UDP-N-acetylglucosamine enolpyruvyl transferase catalyzes enolpyruvyl transfer as part of the first step in the biosynthesis of peptidoglycan, a component of the bacterial cell wall. The reaction is phosphoenolpyruvate + UDP-N-acetyl-D-glucosamine =...; Region: UdpNAET; cd01555 755731011764 hinge; other site 755731011765 active site 755731011766 YycH protein; Region: YycI; cl02015 755731011767 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: VicK; COG5002 755731011768 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 755731011769 dimerization interface [polypeptide binding]; other site 755731011770 PAS domain; Region: PAS; smart00091 755731011771 putative active site [active] 755731011772 heme pocket [chemical binding]; other site 755731011773 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 755731011774 dimer interface [polypeptide binding]; other site 755731011775 phosphorylation site [posttranslational modification] 755731011776 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 755731011777 ATP binding site [chemical binding]; other site 755731011778 Mg2+ binding site [ion binding]; other site 755731011779 G-X-G motif; other site 755731011780 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 755731011781 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 755731011782 active site 755731011783 phosphorylation site [posttranslational modification] 755731011784 intermolecular recognition site; other site 755731011785 dimerization interface [polypeptide binding]; other site 755731011786 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 755731011787 DNA binding site [nucleotide binding] 755731011788 Outer membrane protein [Cell envelope biogenesis, outer membrane / Intracellular trafficking and secretion]; Region: TolC; COG1538 755731011789 rhamnulokinase; Region: rhamnulo_kin; TIGR02627 755731011790 Outer membrane efflux protein; Region: OEP; pfam02321 755731011791 S-layer homology domain; Region: SLH; pfam00395 755731011792 ADP-glucose pyrophosphorylase [Carbohydrate transport and metabolism]; Region: GlgC; COG0448 755731011793 ADP-glucose pyrophosphorylase is involved in the biosynthesis of glycogen or starch; Region: ADP_Glucose_PP; cd02508 755731011794 ligand binding site; other site 755731011795 oligomer interface; other site 755731011796 Glucose-1-phosphate adenylyltransferase, C-terminal Left-handed parallel beta helix (LbH) domain: Glucose-1-phosphate adenylyltransferase is also known as ADP-glucose synthase or ADP-glucose pyrophosphorylase. It catalyzes the first committed and...; Region: LbH_G1P_AT_C; cd04651 755731011797 dimer interface [polypeptide binding]; other site 755731011798 N-terminal domain interface [polypeptide binding]; other site 755731011799 sulfate 1 binding site; other site 755731011800 glucose-1-phosphate adenylyltransferase; Provisional; Region: glgC; PRK05293 755731011801 ADP-glucose pyrophosphorylase is involved in the biosynthesis of glycogen or starch; Region: ADP_Glucose_PP; cd02508 755731011802 ligand binding site; other site 755731011803 oligomer interface; other site 755731011804 Glucose-1-phosphate adenylyltransferase, C-terminal Left-handed parallel beta helix (LbH) domain: Glucose-1-phosphate adenylyltransferase is also known as ADP-glucose synthase or ADP-glucose pyrophosphorylase. It catalyzes the first committed and...; Region: LbH_G1P_AT_C; cd04651 755731011805 dimer interface [polypeptide binding]; other site 755731011806 N-terminal domain interface [polypeptide binding]; other site 755731011807 sulfate 1 binding site; other site 755731011808 glutamate racemase; Provisional; Region: PRK00865 755731011809 bifunctional acetaldehyde-CoA/alcohol dehydrogenase; Provisional; Region: PRK13805 755731011810 Coenzyme A acylating aldehyde dehydrogenase (ACDH), ALDH family 20-like; Region: ALDH_F20_ACDH; cd07122 755731011811 putative catalytic cysteine [active] 755731011812 C-terminal alcohol dehydrogenase domain of the acetaldehyde dehydrogenase-alcohol dehydrogenase bifunctional two-domain protein (AAD); Region: AAD_C; cd08178 755731011813 putative active site [active] 755731011814 metal binding site [ion binding]; metal-binding site 755731011815 This is a subfamily of Adenine nucleotide alpha hydrolases superfamily.Adeninosine nucleotide alpha hydrolases superfamily includes N type ATP PPases and ATP sulphurylases. It forms a apha/beta/apha fold which binds to Adenosine group. This subfamily; Region: Alpha_ANH_like_II; cd01993 755731011816 Ligand Binding Site [chemical binding]; other site 755731011817 Predicted periplasmic protein (DUF2233); Region: DUF2233; pfam09992 755731011818 Prokaryotic UGPase catalyses the synthesis of UDP-glucose; Region: UGPase_prokaryotic; cd02541 755731011819 dTDP-glucose pyrophosphorylase [Cell envelope biogenesis, outer membrane]; Region: RfbA; COG1209 755731011820 active site 755731011821 tetramer interface; other site 755731011822 Predicted membrane protein [Function unknown]; Region: COG3601 755731011823 Protein of unknown function (DUF3816); Region: DUF3816; pfam12822 755731011824 Protein of unknown function (DUF3072); Region: DUF3072; pfam11272 755731011825 Beta-glucosidase-related glycosidases [Carbohydrate transport and metabolism]; Region: BglX; COG1472 755731011826 Glycosyl hydrolase family 3 N terminal domain; Region: Glyco_hydro_3; pfam00933 755731011827 Glycosyl hydrolase family 3 C-terminal domain; Region: Glyco_hydro_3_C; pfam01915 755731011828 TraB family; Region: TraB; pfam01963 755731011829 Cellobiose phosphorylase [Carbohydrate transport and metabolism]; Region: COG3459 755731011830 N-terminal domain of chitobiose phosphorylase (ChBP) and similar proteins; Region: GH94N_ChBP_like; cd11755 755731011831 catalytic domain interface [polypeptide binding]; other site 755731011832 putative homodimer interface [polypeptide binding]; other site 755731011833 ABC-type Mn2+/Zn2+ transport systems, permease components [Inorganic ion transport and metabolism]; Region: ZnuB; COG1108 755731011834 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cl00462 755731011835 ABC-ATPase subunit interface; other site 755731011836 dimer interface [polypeptide binding]; other site 755731011837 putative PBP binding regions; other site 755731011838 ATP-binding cassette domain of the metal-type transporters; Region: ABC_Metallic_Cations; cd03235 755731011839 ABC-type Mn/Zn transport systems, ATPase component [Inorganic ion transport and metabolism]; Region: ZnuC; COG1121 755731011840 Transketolase [Carbohydrate transport and metabolism]; Region: TktA; COG0021 755731011841 Thiamine pyrophosphate (TPP) family, Transketolase (TK) subfamily, TPP-binding module; TK catalyzes the transfer of a two-carbon unit from ketose phosphates to aldose phosphates. In heterotrophic organisms, TK provides a link between glycolysis and the...; Region: TPP_TK; cd02012 755731011842 TPP-binding site [chemical binding]; other site 755731011843 dimer interface [polypeptide binding]; other site 755731011844 Pyrimidine (PYR) binding domain of 1-deoxy-D-xylulose-5-phosphate synthase (DXS), transketolase (TK), and related proteins; Region: TPP_PYR_DXS_TK_like; cd07033 755731011845 PYR/PP interface [polypeptide binding]; other site 755731011846 dimer interface [polypeptide binding]; other site 755731011847 TPP binding site [chemical binding]; other site 755731011848 Transketolase, C-terminal domain; Region: Transketolase_C; pfam02780 755731011849 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 755731011850 salt bridge; other site 755731011851 non-specific DNA binding site [nucleotide binding]; other site 755731011852 sequence-specific DNA binding site [nucleotide binding]; other site 755731011853 Domain of unknown function (DUF4173); Region: DUF4173; pfam13777 755731011854 Predicted ATPase (AAA+ superfamily) [General function prediction only]; Region: COG2607 755731011855 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 755731011856 Walker A motif; other site 755731011857 ATP binding site [chemical binding]; other site 755731011858 Walker B motif; other site 755731011859 M14 family of metallocarboxypeptidases and related proteins; Region: Peptidase_M14_like; cl11393 755731011860 active site 755731011861 Zn binding site [ion binding]; other site 755731011862 Copper amine oxidase N-terminal domain; Region: Cu_amine_oxidN1; pfam07833 755731011863 Superfamily I DNA and RNA helicases [General function prediction only]; Region: COG3973 755731011864 Part of AAA domain; Region: AAA_19; pfam13245 755731011865 Family description; Region: UvrD_C_2; pfam13538 755731011866 Methyltransferase domain; Region: Methyltransf_23; pfam13489 755731011867 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 755731011868 S-adenosylmethionine binding site [chemical binding]; other site 755731011869 2-hydroxyacid dehydrogenase; Provisional; Region: PRK08410 755731011870 Putative D-isomer specific 2-hydroxyacid dehydrogenases; Region: 2-Hacid_dh_4; cd12162 755731011871 putative ligand binding site [chemical binding]; other site 755731011872 putative NAD binding site [chemical binding]; other site 755731011873 catalytic site [active] 755731011874 ABC-type metal ion transport system, permease component [Inorganic ion transport and metabolism]; Region: AbcD; COG2011 755731011875 DL-methionine transporter ATP-binding subunit; Provisional; Region: metN; PRK11153 755731011876 ATP-binding cassette domain of methionine transporter; Region: ABC_MetN_methionine_transporter; cd03258 755731011877 Walker A/P-loop; other site 755731011878 ATP binding site [chemical binding]; other site 755731011879 Q-loop/lid; other site 755731011880 ABC transporter signature motif; other site 755731011881 Walker B; other site 755731011882 D-loop; other site 755731011883 H-loop/switch region; other site 755731011884 NIL domain; Region: NIL; pfam09383 755731011885 ABC-type metal ion transport system, periplasmic component/surface antigen [Inorganic ion transport and metabolism]; Region: NlpA; COG1464 755731011886 NLPA lipoprotein; Region: Lipoprotein_9; pfam03180 755731011887 2-ketoisovalerate ferredoxin oxidoreductase subunit beta; Provisional; Region: PRK11864 755731011888 Thiamine pyrophosphate (TPP family), PFOR porB-like subfamily, TPP-binding module; composed of proteins similar to the beta subunit (porB) of the Helicobacter pylori four-subunit pyruvate ferredoxin oxidoreductase (PFOR), which are also found in archaea...; Region: TPP_PFOR_porB_like; cd03376 755731011889 TPP-binding site [chemical binding]; other site 755731011890 putative dimer interface [polypeptide binding]; other site 755731011891 pyruvate ferredoxin oxidoreductase subunit alpha; Reviewed; Region: porA; PRK08367 755731011892 Pyrimidine (PYR) binding domain of pyruvate ferredoxin oxidoreductase (PFOR), indolepyruvate ferredoxin oxidoreductase alpha subunit (IOR-alpha), and related proteins; Region: TPP_PYR_PFOR_IOR-alpha_like; cd07034 755731011893 dimer interface [polypeptide binding]; other site 755731011894 PYR/PP interface [polypeptide binding]; other site 755731011895 TPP binding site [chemical binding]; other site 755731011896 substrate binding site [chemical binding]; other site 755731011897 Transketolase, C-terminal domain; Region: Transketolase_C; pfam02780 755731011898 RPB11 and RPB3 subunits of RNA polymerase; Region: RNAP_RPB11_RPB3; cl11409 755731011899 pyruvate/ketoisovalerate ferredoxin oxidoreductase subunit gamma; Provisional; Region: PRK14029 755731011900 Pyruvate ferredoxin/flavodoxin oxidoreductase; Region: POR; cl00546 755731011901 Aspartate/tyrosine/aromatic aminotransferase [Amino acid transport and metabolism]; Region: COG0436 755731011902 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 755731011903 pyridoxal 5'-phosphate binding site [chemical binding]; other site 755731011904 homodimer interface [polypeptide binding]; other site 755731011905 catalytic residue [active] 755731011906 Coenzyme F390 synthetase [Coenzyme metabolism]; Region: PaaK; COG1541 755731011907 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 755731011908 acyl-activating enzyme (AAE) consensus motif; other site 755731011909 AMP binding site [chemical binding]; other site 755731011910 active site 755731011911 CoA binding site [chemical binding]; other site 755731011912 alpha-galactosidase; Provisional; Region: PRK15076 755731011913 Glycoside Hydrolases Family 4; Alpha-glucosidases and alpha-galactosidases; Region: GH4_alpha_glucosidase_galactosidase; cd05297 755731011914 NAD binding site [chemical binding]; other site 755731011915 sugar binding site [chemical binding]; other site 755731011916 divalent metal binding site [ion binding]; other site 755731011917 putative tetramer (dimer of dimers) interface [polypeptide binding]; other site 755731011918 dimer interface [polypeptide binding]; other site 755731011919 Proteins of this family catalyze the reduction of flavin or nitrocompounds using NAD(P)H as electron donor in a obligatory two-electron transfer, utilizing FMN or FAD as cofactor. They are often found to be homodimers. Enzymes of this family are...; Region: Nitro_FMN_reductase; cd02062 755731011920 FMN binding site [chemical binding]; other site 755731011921 dimer interface [polypeptide binding]; other site 755731011922 AraC-like ligand binding domain; Region: AraC_binding; pfam02311 755731011923 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 755731011924 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 755731011925 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 755731011926 Na+-driven multidrug efflux pump [Defense mechanisms]; Region: NorM; COG0534 755731011927 Subfamily of the multidrug and toxic compound extrusion (MATE)-like proteins similar to Thermotoga marina NorM; Region: MATE_NorM_like; cd13137 755731011928 xylose isomerase; Provisional; Region: PRK05474 755731011929 xylose isomerase; Region: xylose_isom_A; TIGR02630 755731011930 Winged helix-turn-helix DNA-binding; Region: HTH_24; pfam13412 755731011931 Transcriptional regulators [Transcription]; Region: Lrp; COG1522 755731011932 Transcriptional regulator/sugar kinase [Transcription / Carbohydrate transport and metabolism]; Region: NagC; COG1940 755731011933 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cd00012 755731011934 nucleotide binding site [chemical binding]; other site 755731011935 Escherichia coli xylulokinase-like D-xylulose kinases; a subgroup of the FGGY family of carbohydrate kinases; Region: FGGY_D-XK_EcXK-like; cd07808 755731011936 N- and C-terminal domain interface [polypeptide binding]; other site 755731011937 D-xylulose kinase; Region: XylB; TIGR01312 755731011938 active site 755731011939 MgATP binding site [chemical binding]; other site 755731011940 catalytic site [active] 755731011941 metal binding site [ion binding]; metal-binding site 755731011942 xylulose binding site [chemical binding]; other site 755731011943 homodimer interface [polypeptide binding]; other site 755731011944 putative alpha-isopropylmalate/homocitrate synthase family transferase; Provisional; Region: PRK12344 755731011945 Desulfobacterium autotrophicum LeuA3 and related proteins, N-terminal catalytic TIM barrel domain; Region: DRE_TIM_LeuA3; cd07941 755731011946 active site 755731011947 catalytic residues [active] 755731011948 metal binding site [ion binding]; metal-binding site 755731011949 LeuA allosteric (dimerisation) domain; Region: LeuA_dimer; smart00917 755731011950 2-isopropylmalate synthase; Validated; Region: PRK00915 755731011951 2-isopropylmalate synthase (IPMS), N-terminal catalytic TIM barrel domain; Region: DRE_TIM_IPMS; cd07940 755731011952 active site 755731011953 catalytic residues [active] 755731011954 metal binding site [ion binding]; metal-binding site 755731011955 LeuA allosteric (dimerisation) domain; Region: LeuA_dimer; smart00917 755731011956 ketol-acid reductoisomerase; Provisional; Region: PRK05479 755731011957 Acetohydroxy acid isomeroreductase, catalytic domain; Region: IlvN; pfam07991 755731011958 Acetohydroxy acid isomeroreductase, catalytic domain; Region: IlvC; pfam01450 755731011959 acetolactate synthase 3 regulatory subunit; Reviewed; Region: ilvH; PRK11895 755731011960 N-terminal ACT domain of the Escherichia coli IlvH-like regulatory subunit of acetohydroxyacid synthase (AHAS); Region: ACT_AHAS; cd04878 755731011961 putative valine binding site [chemical binding]; other site 755731011962 dimer interface [polypeptide binding]; other site 755731011963 Small subunit of acetolactate synthase; Region: ALS_ss_C; pfam10369 755731011964 acetolactate synthase 3 catalytic subunit; Reviewed; Region: PRK06048 755731011965 Pyrimidine (PYR) binding domain of POX and related proteins; Region: TPP_PYR_POX_like; cd07035 755731011966 PYR/PP interface [polypeptide binding]; other site 755731011967 dimer interface [polypeptide binding]; other site 755731011968 TPP binding site [chemical binding]; other site 755731011969 Thiamine pyrophosphate enzyme, central domain; Region: TPP_enzyme_M; pfam00205 755731011970 Thiamine pyrophosphate (TPP) family, Acetohydroxyacid synthase (AHAS) subfamily, TPP-binding module; composed of proteins similar to the large catalytic subunit of AHAS. AHAS catalyzes the condensation of two molecules of pyruvate to give the...; Region: TPP_AHAS; cd02015 755731011971 TPP-binding site [chemical binding]; other site 755731011972 dimer interface [polypeptide binding]; other site 755731011973 Beta-xylosidase [Carbohydrate transport and metabolism]; Region: XynB; COG3507 755731011974 Glycosyl hydrolase family 43, beta-D-xylosidase; Region: GH43_XYL_1; cd09000 755731011975 inhibitor binding site; inhibition site 755731011976 active site 755731011977 Protein Disulfide Oxidoreductases and Other Proteins with a Thioredoxin fold; Region: Thioredoxin_like; cl00388 755731011978 Nucleoside deaminases include adenosine, guanine and cytosine deaminases. These enzymes are Zn dependent and catalyze the deamination of nucleosides. The zinc ion in the active site plays a central role in the proposed catalytic mechanism, activating a...; Region: nucleoside_deaminase; cd01285 755731011979 nucleoside/Zn binding site; other site 755731011980 dimer interface [polypeptide binding]; other site 755731011981 catalytic motif [active] 755731011982 GDP-D-mannose dehydratase [Cell envelope biogenesis, outer membrane]; Region: Gmd; COG1089 755731011983 GDP-mannose 4,6 dehydratase, extended (e) SDRs; Region: GDP_MD_SDR_e; cd05260 755731011984 NADP-binding site; other site 755731011985 homotetramer interface [polypeptide binding]; other site 755731011986 substrate binding site [chemical binding]; other site 755731011987 homodimer interface [polypeptide binding]; other site 755731011988 active site 755731011989 GDP-fucose synthetase, extended (e) SDRs; Region: GDP_FS_SDR_e; cd05239 755731011990 GDP-4-keto-6-deoxymannose-3, 5-epimerase-4-reductase; Region: PLN02725 755731011991 NADP binding site [chemical binding]; other site 755731011992 active site 755731011993 putative substrate binding site [chemical binding]; other site 755731011994 DivIVA protein; Region: DivIVA; pfam05103 755731011995 Phosphotransferase enzyme family; Region: APH; pfam01636 755731011996 Aminoglycoside 3'-phosphotransferase (APH) and Choline Kinase (ChoK) family. The APH/ChoK family is part of a larger superfamily that includes the catalytic domains of other kinases, such as the typical serine/threonine/tyrosine protein kinases (PKs)...; Region: APH_ChoK_like; cl17270 755731011997 active site 755731011998 ATP binding site [chemical binding]; other site 755731011999 substrate binding site [chemical binding]; other site 755731012000 Nodulation protein Z (NodZ); Region: NodZ; pfam05830 755731012001 GDP-fucose protein O-fucosyltransferase and related proteins; Region: O-FucT_like; cd11296 755731012002 GDP-Fucose binding site [chemical binding]; other site 755731012003 GDP-fucose protein O-fucosyltransferase and related proteins; Region: O-FucT_like; cl16914 755731012004 GDP-fucose protein O-fucosyltransferase and related proteins; Region: O-FucT_like; cd11296 755731012005 GDP-Fucose binding site [chemical binding]; other site 755731012006 GDP-fucose protein O-fucosyltransferase and related proteins; Region: O-FucT_like; cd11296 755731012007 GDP-Fucose binding site [chemical binding]; other site 755731012008 Peptidase S8 family domain, uncharacterized subfamily 8; Region: Peptidases_S8_8; cd07492 755731012009 active site 755731012010 catalytic triad [active] 755731012011 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 755731012012 Nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: WcaG; COG0451 755731012013 NAD(P) binding site [chemical binding]; other site 755731012014 active site 755731012015 Pyruvate/2-oxoglutarate dehydrogenase complex, dehydrogenase (E1) component, eukaryotic type, beta subunit [Energy production and conversion]; Region: AcoB; COG0022 755731012016 Pyrimidine (PYR) binding domain of the beta subunits of the E1 components of human pyruvate dehydrogenase complex (E1- PDHc) and related proteins; Region: TPP_PYR_E1-PDHc-beta_like; cd07036 755731012017 alpha subunit interface [polypeptide binding]; other site 755731012018 TPP binding site [chemical binding]; other site 755731012019 heterodimer interface [polypeptide binding]; other site 755731012020 Transketolase, C-terminal domain; Region: Transketolase_C; pfam02780 755731012021 pyruvate dehydrogenase E1 component, alpha subunit; Region: PDH_E1_alph_y; TIGR03182 755731012022 Thiamine pyrophosphate (TPP) family, E1 of PDC_ADC_BCADC subfamily, TPP-binding module; composed of proteins similar to the E1 components of the human pyruvate dehydrogenase complex (PDC), the acetoin dehydrogenase complex (ADC) and the branched chain...; Region: TPP_E1_PDC_ADC_BCADC; cd02000 755731012023 tetramer interface [polypeptide binding]; other site 755731012024 TPP-binding site [chemical binding]; other site 755731012025 heterodimer interface [polypeptide binding]; other site 755731012026 phosphorylation loop region [posttranslational modification] 755731012027 GDP-fucose protein O-fucosyltransferase and related proteins; Region: O-FucT_like; cd11296 755731012028 GDP-Fucose binding site [chemical binding]; other site 755731012029 GDP-M1P_Guanylyltransferase catalyzes the formation of GDP-Mannose; Region: GDP-M1P_Guanylyltransferase; cd02509 755731012030 Mannose-1-phosphate guanylyltransferase [Cell envelope biogenesis, outer membrane]; Region: {ManC}; COG0836 755731012031 Substrate binding site; other site 755731012032 Cupin domain; Region: Cupin_2; cl17218 755731012033 4-amino-4-deoxy-L-arabinose-phosphoundecaprenol flippase subunit ArnF; Provisional; Region: PRK02971 755731012034 dolichyl-phosphate beta-D-mannosyltransferase; Region: PLN02726 755731012035 DPM_DPG-synthase_like is a member of the Glycosyltransferase 2 superfamily; Region: DPM_DPG-synthase_like; cd04179 755731012036 Ligand binding site; other site 755731012037 Putative Catalytic site; other site 755731012038 DXD motif; other site 755731012039 Uncharacterized conserved protein (DUF2304); Region: DUF2304; pfam10066 755731012040 leucyl-tRNA synthetase; Validated; Region: leuS; PRK00390 755731012041 catalytic core domain of leucyl-tRNA synthetases; Region: LeuRS_core; cd00812 755731012042 HIGH motif; other site 755731012043 Leucyl-tRNA synthetase, Domain 2; Region: tRNA-synt_1_2; pfam13603 755731012044 nucleotidyl transferase superfamily; Region: nt_trans; cl00015 755731012045 active site 755731012046 KMSKS motif; other site 755731012047 Anticodon-binding domain of bacterial and eukaryotic mitochondrial leucyl tRNA synthetases; Region: Anticodon_Ia_Leu_BEm; cd07958 755731012048 tRNA binding surface [nucleotide binding]; other site 755731012049 Accessory gene regulator B; Region: AgrB; pfam04647 755731012050 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 755731012051 ATP binding site [chemical binding]; other site 755731012052 Mg2+ binding site [ion binding]; other site 755731012053 G-X-G motif; other site 755731012054 SWIM zinc finger; Region: SWIM; pfam04434 755731012055 Bacterial SNF2 helicase associated; Region: SNF2_assoc; pfam08455 755731012056 SNF2 family N-terminal domain; Region: SNF2_N; pfam00176 755731012057 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 755731012058 ATP binding site [chemical binding]; other site 755731012059 putative Mg++ binding site [ion binding]; other site 755731012060 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 755731012061 nucleotide binding region [chemical binding]; other site 755731012062 ATP-binding site [chemical binding]; other site 755731012063 Thermophilic metalloprotease (M29); Region: Peptidase_M29; pfam02073 755731012064 Leucyl aminopeptidase (aminopeptidase T) [Amino acid transport and metabolism]; Region: AmpS; COG2309 755731012065 oligoendopeptidase F; Region: pepF; TIGR00181 755731012066 Peptidase family M3B Oligopeptidase F (PepF); Region: M3B_PepF_3; cd09608 755731012067 active site 755731012068 Zn binding site [ion binding]; other site 755731012069 Alpha-tubulin suppressor and related RCC1 domain-containing proteins [Cell division and chromosome partitioning / Cytoskeleton]; Region: ATS1; COG5184 755731012070 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 755731012071 Major Facilitator Superfamily; Region: MFS_1; pfam07690 755731012072 putative substrate translocation pore; other site 755731012073 Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596 755731012074 Bacterial Ig-like domain (group 2); Region: Big_2; pfam02368 755731012075 DOMON-like type 9 carbohydrate binding module of xylanases; Region: CBM9_like_1; cd00005 755731012076 Ca binding site [ion binding]; other site 755731012077 carbohydrate binding site [chemical binding]; other site 755731012078 Predicted hydrolase of the alpha/beta superfamily [General function prediction only]; Region: COG2819 755731012079 Putative esterase; Region: Esterase; pfam00756 755731012080 Transcriptional regulators [Transcription]; Region: PurR; COG1609 755731012081 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 755731012082 DNA binding site [nucleotide binding] 755731012083 domain linker motif; other site 755731012084 Ligand-binding domain of DNA transcription repressor for the hexuronate utilization operon from Bacillus species and its close homologs from other bacteria, all of which are a member of the LacI-GalR family of bacterial transcription regulators; Region: PBP1_hexuronate_repressor_like; cd06272 755731012085 putative dimerization interface [polypeptide binding]; other site 755731012086 putative ligand binding site [chemical binding]; other site 755731012087 Uncharacterized protein family (UPF0180); Region: UPF0180; pfam03698 755731012088 L-ribulose-5-phosphate 4-epimerase; Reviewed; Region: araD; PRK08193 755731012089 Class II Aldolase and Adducin head (N-terminal) domain. Aldolases are ubiquitous enzymes catalyzing central steps of carbohydrate metabolism. Based on enzymatic mechanisms, this superfamily has been divided into two distinct classes (Class I and II); Region: Aldolase_II; cd00398 755731012090 intersubunit interface [polypeptide binding]; other site 755731012091 active site 755731012092 Zn2+ binding site [ion binding]; other site 755731012093 L-ribulokinase-like proteins; a subfamily of the FGGY family of carbohydrate kinases; Region: FGGY_L-RBK_like; cd07778 755731012094 Sugar (pentulose and hexulose) kinases [Carbohydrate transport and metabolism]; Region: XylB; COG1070 755731012095 putative N- and C-terminal domain interface [polypeptide binding]; other site 755731012096 putative active site [active] 755731012097 MgATP binding site [chemical binding]; other site 755731012098 catalytic site [active] 755731012099 metal binding site [ion binding]; metal-binding site 755731012100 putative carbohydrate binding site [chemical binding]; other site 755731012101 L-fucose isomerase and related proteins [Carbohydrate transport and metabolism]; Region: FucI; COG2407 755731012102 L-fucose isomerase (FucIase) and L-arabinose isomerase (AI) family; composed of FucIase, AI and similar proteins. FucIase converts L-fucose, an aldohexose, to its ketose form, which prepares it for aldol cleavage (similar to the isomerization of glucose...; Region: L-fuc_L-ara-isomerases; cd00578 755731012103 hexamer (dimer of trimers) interface [polypeptide binding]; other site 755731012104 substrate binding site [chemical binding]; other site 755731012105 trimer interface [polypeptide binding]; other site 755731012106 Mn binding site [ion binding]; other site 755731012107 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 755731012108 DNA-binding site [nucleotide binding]; DNA binding site 755731012109 Transcriptional regulators [Transcription]; Region: PurR; COG1609 755731012110 Ligand-binding domain of DNA transcription repressor specific for arabinose (AraR) which is a member of the LacI-GalR family of bacterial transcription regulators; Region: PBP1_AraR; cd01541 755731012111 putative dimerization interface [polypeptide binding]; other site 755731012112 putative ligand binding site [chemical binding]; other site 755731012113 Uncharacterized protein family UPF0047; Region: UPF0047; pfam01894 755731012114 putative DNA-binding transcriptional regulator; Reviewed; Region: PRK00347 755731012115 desulfoferrodoxin; Region: dfx_rbo; TIGR00320 755731012116 Desulforedoxin (DSRD) domain; a small non-heme iron domain present in the desulforedoxin (rubredoxin oxidoreductase) and desulfoferrodoxin proteins of some archeael and bacterial methanogens and sulfate/sulfur reducers. Desulforedoxin is a small; Region: DSRD; cd00974 755731012117 non-heme iron binding site [ion binding]; other site 755731012118 dimer interface [polypeptide binding]; other site 755731012119 Desulfoferrodoxin; Region: Desulfoferrodox; pfam01880 755731012120 non-heme iron binding site [ion binding]; other site 755731012121 2-deoxyribose-5-phosphate aldolase (DERA) of the DeoC family; Region: DeoC; cd00959 755731012122 intersubunit interface [polypeptide binding]; other site 755731012123 active site 755731012124 catalytic residue [active] 755731012125 putative lipid kinase; Reviewed; Region: PRK13059 755731012126 Diacylglycerol kinase catalytic domain; Region: DAGK_cat; pfam00781 755731012127 Small, acid-soluble spore proteins, alpha/beta type; Region: SASP; pfam00269 755731012128 Nicotinate-nucleotide pyrophosphorylase [Coenzyme metabolism]; Region: NadC; COG0157 755731012129 Quinolinate phosphoribosyl transferase (QAPRTase or QPRTase), also called nicotinate-nucleotide pyrophosphorylase, is involved in the de novo synthesis of NAD in both prokaryotes and eukaryotes. It catalyses the reaction of quinolinic acid (QA) with...; Region: QPRTase; cd01572 755731012130 dimerization interface [polypeptide binding]; other site 755731012131 active site 755731012132 Aspartate oxidase [Coenzyme metabolism]; Region: NadB; COG0029 755731012133 L-aspartate oxidase; Provisional; Region: PRK06175 755731012134 Fumarate reductase flavoprotein C-term; Region: Succ_DH_flav_C; pfam02910 755731012135 Quinolinate synthetase A protein; Region: NadA; pfam02445 755731012136 Fe2+ transport system protein B [Inorganic ion transport and metabolism]; Region: FeoB; COG0370 755731012137 Ferrous iron transport protein B (FeoB) family; Region: FeoB; cd01879 755731012138 G1 box; other site 755731012139 GTP/Mg2+ binding site [chemical binding]; other site 755731012140 Switch I region; other site 755731012141 G2 box; other site 755731012142 G3 box; other site 755731012143 Switch II region; other site 755731012144 G4 box; other site 755731012145 G5 box; other site 755731012146 Nucleoside recognition; Region: Gate; pfam07670 755731012147 Ferrous iron transport protein B C terminus; Region: FeoB_C; pfam07664 755731012148 Nucleoside recognition; Region: Gate; pfam07670 755731012149 Fe2+ transport system protein A [Inorganic ion transport and metabolism]; Region: FeoA; COG1918 755731012150 FeoA domain; Region: FeoA; pfam04023 755731012151 IclR helix-turn-helix domain; Region: HTH_IclR; cl17605 755731012152 Helix-turn-helix diphteria tox regulatory element; Region: HTH_DTXR; smart00529 755731012153 Iron dependent repressor, metal binding and dimerisation domain; Region: Fe_dep_repr_C; pfam02742 755731012154 DNA gyrase subunit A; Validated; Region: PRK05560 755731012155 DNA Topoisomerase, subtype IIA; domain A'; bacterial DNA topoisomerase IV (C subunit, ParC), bacterial DNA gyrases (A subunit, GyrA),mammalian DNA toposiomerases II. DNA topoisomerases are essential enzymes that regulate the conformational changes...; Region: TOP4c; cd00187 755731012156 CAP-like domain; other site 755731012157 active site 755731012158 primary dimer interface [polypeptide binding]; other site 755731012159 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 755731012160 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 755731012161 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 755731012162 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 755731012163 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 755731012164 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 755731012165 nucleoid occlusion protein; Region: nucleoid_noc; TIGR04285 755731012166 ParB-like nuclease domain; Region: ParBc; pfam02195 755731012167 Predicted S-adenosylmethionine-dependent methyltransferase involved in bacterial cell division [Cell envelope biogenesis, outer membrane]; Region: GidB; COG0357 755731012168 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 755731012169 S-adenosylmethionine binding site [chemical binding]; other site 755731012170 tRNA uridine 5-carboxymethylaminomethyl modification enzyme GidA; Validated; Region: PRK05192 755731012171 NAD(FAD)-utilizing enzyme possibly involved in translation [Translation, ribosomal structure and biogenesis]; Region: Gid; COG1206 755731012172 GidA associated domain 3; Region: GIDA_assoc_3; pfam13932 755731012173 tRNA modification GTPase TrmE; Reviewed; Region: trmE; PRK05291 755731012174 GTP-binding protein TrmE N-terminus; Region: TrmE_N; pfam10396 755731012175 trmE is a tRNA modification GTPase; Region: trmE; cd04164 755731012176 G1 box; other site 755731012177 GTP/Mg2+ binding site [chemical binding]; other site 755731012178 Switch I region; other site 755731012179 G2 box; other site 755731012180 Switch II region; other site 755731012181 G3 box; other site 755731012182 G4 box; other site 755731012183 G5 box; other site 755731012184 Catalytic cysteine-containing C-terminus of GTPase, MnmE; Region: GTPase_Cys_C; pfam12631 755731012185 Predicted RNA-binding protein [General function prediction only]; Region: Jag; COG1847 755731012186 jag_K homology RNA-binding domain. The KH domain is found in proteins homologous to the Bacillus subtilis protein Jag, which is associated with SpoIIIJ and is necessary for the third stage of sporulation. The KH motif is a beta-alpha-alpha-beta-beta...; Region: jag_KH; cd02414 755731012187 G-X-X-G motif; other site 755731012188 R3H domain found in proteins homologous to Bacillus subtilus Jag, which is associated with SpoIIIJ. SpoIIIJ is necessary for the third stage of sporulation. The name of the R3H domain comes from the characteristic spacing of the most conserved arginine...; Region: R3H_jag; cd02644 755731012189 RxxxH motif; other site 755731012190 membrane protein insertase, YidC/Oxa1 family, C-terminal domain; Region: yidC_oxa1_cterm; TIGR03592 755731012191 60Kd inner membrane protein; Region: 60KD_IMP; cl00489 755731012192 Haemolytic domain; Region: Haemolytic; pfam01809 755731012193 ribonuclease P; Reviewed; Region: rnpA; PRK00499 755731012194 Ribosomal protein L34; Region: Ribosomal_L34; cl00370