-- dump date 20140619_042132 -- class Genbank::misc_feature -- table misc_feature_note -- id note 443906000001 YcfA-like protein; Region: YcfA; pfam07927 443906000002 Helix-turn-helix domain of Hin and related proteins, a family of DNA-binding domains unique to bacteria and represented by the Hin protein of Salmonella. The basic HTH domain is a simple fold comprised of three core helices that form a right-handed...; Region: HTH_Hin_like; cl17393 443906000003 ATPases involved in chromosome partitioning [Cell division and chromosome partitioning]; Region: Soj; COG1192 443906000004 ParA and ParB of Caulobacter crescentus belong to a conserved family of bacterial proteins implicated in chromosome segregation. ParB binds to DNA sequences adjacent to the origin of replication and localizes to opposite cell poles shortly following the...; Region: ParA; cd02042 443906000005 Magnesium ion binding site [ion binding]; other site 443906000006 L1 transposable element; Region: Transposase_22; pfam02994 443906000007 AAA-like domain; Region: AAA_10; pfam12846 443906000008 Phospholipase_D-nuclease N-terminal; Region: PLDc_N; pfam13396 443906000009 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 443906000010 putative DNA binding site [nucleotide binding]; other site 443906000011 putative Zn2+ binding site [ion binding]; other site 443906000012 AAA-like domain; Region: AAA_10; pfam12846 443906000013 Protein of unknown function (DUF1524); Region: DUF1524; pfam07510 443906000014 Cellulase (glycosyl hydrolase family 5); Region: Cellulase; pfam00150 443906000015 Endoglucanase [Carbohydrate transport and metabolism]; Region: BglC; COG2730 443906000016 CBD_II domain; Region: CBD_II; smart00637 443906000017 Endoglucanase C-terminal domain/subunit and related proteins [Carbohydrate transport and metabolism]; Region: COG4305 443906000018 Rare lipoprotein A (RlpA)-like double-psi beta-barrel; Region: DPBB_1; pfam03330 443906000019 Serine Recombinase (SR) family, Resolvase and Invertase subfamily, catalytic domain; members contain a C-terminal DNA binding domain. Serine recombinases catalyze site-specific recombination of DNA molecules by a concerted, four-strand cleavage and...; Region: SR_ResInv; cd03768 443906000020 catalytic residues [active] 443906000021 catalytic nucleophile [active] 443906000022 Site-specific recombinases, DNA invertase Pin homologs [DNA replication, recombination, and repair]; Region: PinR; COG1961 443906000023 Presynaptic Site I dimer interface [polypeptide binding]; other site 443906000024 Synaptic Antiparallel dimer interface [polypeptide binding]; other site 443906000025 Synaptic Flat tetramer interface [polypeptide binding]; other site 443906000026 Synaptic Site I dimer interface [polypeptide binding]; other site 443906000027 DNA binding site [nucleotide binding] 443906000028 Helix-turn-helix domain of Hin and related proteins, a family of DNA-binding domains unique to bacteria and represented by the Hin protein of Salmonella. The basic HTH domain is a simple fold comprised of three core helices that form a right-handed...; Region: HTH_Hin_like; cd00569 443906000029 DNA-binding interface [nucleotide binding]; DNA binding site 443906000030 ParB-like nuclease domain; Region: ParBc; pfam02195 443906000031 ParB/RepB/Spo0J family partition protein; Region: parB_part; TIGR00180 443906000032 Domain of unknown function (DUF1738); Region: DUF1738; pfam08401 443906000033 Antirestriction protein [DNA replication, recombination, and repair]; Region: COG4227 443906000034 Replication protein A, class 2b aminoacyl-tRNA synthetases, and related proteins with oligonucleotide/oligosaccharide (OB) fold; Region: RPA_2b-aaRSs_OBF_like; cl09930 443906000035 generic binding surface I; other site 443906000036 generic binding surface II; other site 443906000037 Protein of unknown function (DUF1524); Region: DUF1524; pfam07510 443906000038 conjugative relaxase domain, TrwC/TraI family; Region: relax_trwC; TIGR02686 443906000039 TrwC relaxase; Region: TrwC; pfam08751 443906000040 conjugative relaxase domain, TrwC/TraI family; Region: relax_trwC; TIGR02686 443906000041 AAA domain; Region: AAA_30; pfam13604 443906000042 Family description; Region: UvrD_C_2; pfam13538 443906000043 Type IV secretory pathway, VirD4 components [Intracellular trafficking and secretion]; Region: VirD4; COG3505 443906000044 RecA-like NTPases. This family includes the NTP binding domain of F1 and V1 H+ATPases, DnaB and related helicases as well as bacterial RecA and related eukaryotic and archaeal recombinases. This group also includes bacterial conjugation proteins and...; Region: RecA-like_NTPases; cl17233 443906000045 Walker A motif; other site 443906000046 ATP binding site [chemical binding]; other site 443906000047 TraM recognition site of TraD and TraG; Region: TraG-D_C; pfam12696 443906000048 Walker B motif; other site 443906000049 hypothetical protein 443906000050 hypothetical protein 443906000051 Cell wall-associated hydrolases (invasion-associated proteins) [Cell envelope biogenesis, outer membrane]; Region: Spr; COG0791 443906000052 NlpC/P60 family; Region: NLPC_P60; pfam00877 443906000053 Antiactivator of flagellar biosynthesis FleN, an ATPase [Cell motility]; Region: flhG; COG0455 443906000054 AAA-like domain; Region: AAA_10; pfam12846 443906000055 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 443906000056 Prolyl oligopeptidase family; Region: Peptidase_S9; pfam00326 443906000057 Helix-turn-helix domain; Region: HTH_31; pfam13560 443906000058 IclR helix-turn-helix domain; Region: HTH_IclR; cl17605 443906000059 ATPases involved in chromosome partitioning [Cell division and chromosome partitioning]; Region: Soj; COG1192 443906000060 ParA and ParB of Caulobacter crescentus belong to a conserved family of bacterial proteins implicated in chromosome segregation. ParB binds to DNA sequences adjacent to the origin of replication and localizes to opposite cell poles shortly following the...; Region: ParA; cd02042 443906000061 P-loop; other site 443906000062 Magnesium ion binding site [ion binding]; other site 443906000063 Uncharacterized protein conserved in Bacteroidetes; Region: Bacuni_01323_like; cd12871 443906000064 Rhs family protein [Cell envelope biogenesis, outer membrane]; Region: RhsA; COG3209 443906000065 RHS Repeat; Region: RHS_repeat; pfam05593 443906000066 RHS repeat-associated core domain; Region: Rhs_assc_core; TIGR03696 443906000067 Lsr2; Region: Lsr2; pfam11774 443906000068 Uncharacterized ACR, COG2135; Region: DUF159; pfam02586 443906000069 Type VII secretion system (T7SS), usher protein; Region: Usher; pfam00577 443906000070 Domain of unknown function (DUF1508); Region: DUF1508; cl01356 443906000071 SGNH_hydrolase, or GDSL_hydrolase, is a diverse family of lipases and esterases. The tertiary fold of the enzyme is substantially different from that of the alpha/beta hydrolase family and unique among all known hydrolases; its active site closely...; Region: SGNH_hydrolase; cl01053 443906000072 active site 443906000073 oxyanion hole [active] 443906000074 nuc_hydro: Nucleoside hydrolases. Nucleoside hydrolases cleave the N-glycosidic bond in nucleosides generating ribose and the respective base. These enzymes vary in their substrate specificity. This group contains eukaryotic, bacterial and archeal...; Region: nuc_hydro; cl00226 443906000075 Trypsin-like serine protease; Many of these are synthesized as inactive precursor zymogens that are cleaved during limited proteolysis to generate their active forms. Alignment contains also inactive enzymes that have substitutions of the catalytic triad...; Region: Tryp_SPc; cl00149 443906000076 Trypsin-like serine protease; Many of these are synthesized as inactive precursor zymogens that are cleaved during limited proteolysis to generate their active forms. Alignment contains also inactive enzymes that have substitutions of the catalytic triad...; Region: Tryp_SPc; cl00149 443906000077 Trypsin-like serine protease; Many of these are synthesized as inactive precursor zymogens that are cleaved during limited proteolysis to generate their active forms. Alignment contains also inactive enzymes that have substitutions of the catalytic triad...; Region: Tryp_SPc; cl00149 443906000078 Nucleotidyl transferase of unknown function (DUF1814); Region: DUF1814; pfam08843 443906000079 Domain of unknown function (DUF4095); Region: DUF4095; pfam13338 443906000080 Uncharacterized protein conserved in bacteria (DUF2188); Region: DUF2188; pfam09954 443906000081 glutathione-regulated potassium-efflux system protein KefB; Provisional; Region: PRK03659 443906000082 Fic/DOC family; Region: Fic; cl00960 443906000083 chromosomal replication initiator protein DnaA; Region: DnaA; TIGR00362 443906000084 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 443906000085 Walker A motif; other site 443906000086 ATP binding site [chemical binding]; other site 443906000087 Walker B motif; other site 443906000088 arginine finger; other site 443906000089 C-terminal domain of bacterial DnaA proteins. The DNA-binding C-terminal domain of DnaA contains a helix-turn-helix motif that specifically interacts with the DnaA box, a 9-mer motif that occurs repetitively in the replication origin oriC. Multiple...; Region: Bac_DnaA_C; cd06571 443906000090 DnaA box-binding interface [nucleotide binding]; other site 443906000091 DNA polymerase III subunit beta; Validated; Region: PRK07761 443906000092 Beta clamp domain. The beta subunit (processivity factor) of DNA polymerase III holoenzyme, refered to as the beta clamp, forms a ring shaped dimer that encircles dsDNA (sliding clamp) in bacteria. The beta-clamp is structurally similar to the trimeric...; Region: beta_clamp; cd00140 443906000093 putative DNA binding surface [nucleotide binding]; other site 443906000094 dimer interface [polypeptide binding]; other site 443906000095 beta-clamp/clamp loader binding surface; other site 443906000096 beta-clamp/translesion DNA polymerase binding surface; other site 443906000097 6-phosphogluconate dehydrogenase-like protein; Reviewed; Region: PRK09599 443906000098 6-phosphogluconate dehydrogenase-like protein; Reviewed; Region: PRK12490 443906000099 recombination protein F; Reviewed; Region: recF; PRK00064 443906000100 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 443906000101 Walker A/P-loop; other site 443906000102 ATP binding site [chemical binding]; other site 443906000103 Q-loop/lid; other site 443906000104 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 443906000105 ABC transporter signature motif; other site 443906000106 Walker B; other site 443906000107 D-loop; other site 443906000108 H-loop/switch region; other site 443906000109 Protein of unknown function (DUF721); Region: DUF721; cl02324 443906000110 DNA gyrase subunit B; Validated; Region: gyrB; PRK05644 443906000111 TopoIIA_Trans_DNA_gyrase: Transducer domain, having a ribosomal S5 domain 2-like fold, of the type found in proteins of the type IIA family of DNA topoisomerases similar to the B subunits of E. coli DNA gyrase and E. coli Topoisomerase IV which are; Region: TopoII_Trans_DNA_gyrase; cd00822 443906000112 anchoring element; other site 443906000113 dimer interface [polypeptide binding]; other site 443906000114 ATP binding site [chemical binding]; other site 443906000115 TOPRIM_TopoIIA_GyrB: topoisomerase-primase (TOPRIM) nucleotidyl transferase/hydrolase domain of the type found in proteins of the type IIA family of DNA topoisomerases similar to the Escherichia coli GyrB subunit. TopoIIA enzymes cut both strands of the...; Region: TOPRIM_TopoIIA_GyrB; cd03366 443906000116 active site 443906000117 putative metal-binding site [ion binding]; other site 443906000118 DNA gyrase B subunit, carboxyl terminus; Region: DNA_gyraseB_C; pfam00986 443906000119 DNA gyrase subunit A; Validated; Region: PRK05560 443906000120 DNA Topoisomerase, subtype IIA; domain A'; bacterial DNA topoisomerase IV (C subunit, ParC), bacterial DNA gyrases (A subunit, GyrA),mammalian DNA toposiomerases II. DNA topoisomerases are essential enzymes that regulate the conformational changes...; Region: TOP4c; cd00187 443906000121 CAP-like domain; other site 443906000122 active site 443906000123 primary dimer interface [polypeptide binding]; other site 443906000124 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 443906000125 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 443906000126 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 443906000127 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 443906000128 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 443906000129 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 443906000130 Transmembrane domain of unknown function (DUF3566); Region: DUF3566; pfam12089 443906000131 cyclophilin: cyclophilin-type peptidylprolyl cis- trans isomerases. This family contains eukaryotic, bacterial and archeal proteins which exhibit a peptidylprolyl cis- trans isomerases activity (PPIase, Rotamase) and in addition bind the...; Region: cyclophilin; cd00317 443906000132 active site 443906000133 Membrane associated serine protease [Amino acid transport and metabolism]; Region: COG0705 443906000134 Uncharacterized protein family (UPF0233); Region: UPF0233; pfam06781 443906000135 Sortase D (SrtD) is a membrane transpeptidase found in gram-positive bacteria that anchors surface proteins to peptidoglycans of the bacterial cell wall envelope. This involves a transpeptidation reaction in which the surface protein substrate is cleaved...; Region: Sortase_D_5; cd05830 443906000136 active site 443906000137 catalytic site [active] 443906000138 Type 1 glutamine amidotransferase (GATase1) domain found in Anthranilate synthase; Region: GATase1_Anthranilate_Synthase; cd01743 443906000139 Glutamine amidotransferase class-I; Region: GATase; pfam00117 443906000140 glutamine binding [chemical binding]; other site 443906000141 catalytic triad [active] 443906000142 Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220 443906000143 Catalytic domain of Protein Kinases; Region: PKc; cd00180 443906000144 active site 443906000145 ATP binding site [chemical binding]; other site 443906000146 substrate binding site [chemical binding]; other site 443906000147 activation loop (A-loop); other site 443906000148 PASTA domain of bacterial serine/threonine kinase pknB-like proteins. PknB is a member of a group of related transmembrane sensor kinases present in many gram positive bacteria, which has been shown to regulate cell shape in Mycobacterium tubercolosis; Region: PASTA_pknB; cd06577 443906000149 PASTA domain of bacterial serine/threonine kinase pknB-like proteins. PknB is a member of a group of related transmembrane sensor kinases present in many gram positive bacteria, which has been shown to regulate cell shape in Mycobacterium tubercolosis; Region: PASTA_pknB; cd06577 443906000150 PASTA domain; Region: PASTA; pfam03793 443906000151 Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220 443906000152 Catalytic domain of Protein Kinases; Region: PKc; cd00180 443906000153 active site 443906000154 ATP binding site [chemical binding]; other site 443906000155 substrate binding site [chemical binding]; other site 443906000156 activation loop (A-loop); other site 443906000157 PASTA domain of bacterial serine/threonine kinase pknB-like proteins. PknB is a member of a group of related transmembrane sensor kinases present in many gram positive bacteria, which has been shown to regulate cell shape in Mycobacterium tubercolosis; Region: PASTA_pknB; cd06577 443906000158 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; pfam00905 443906000159 Bacterial cell division membrane protein [Cell division and chromosome partitioning]; Region: FtsW; COG0772 443906000160 Serine/threonine phosphatases, family 2C, catalytic domain; The protein architecture and deduced catalytic mechanism of PP2C phosphatases are similar to the PP1, PP2A, PP2B family of protein Ser/Thr phosphatases, with which PP2C shares no sequence...; Region: PP2Cc; cd00143 443906000161 active site 443906000162 FOG: FHA domain [Signal transduction mechanisms]; Region: COG1716 443906000163 Forkhead associated domain (FHA); found in eukaryotic and prokaryotic proteins. Putative nuclear signalling domain. FHA domains may bind phosphothreonine, phosphoserine and sometimes phosphotyrosine. In eukaryotes, many FHA domain-containing proteins...; Region: FHA; cd00060 443906000164 phosphopeptide binding site; other site 443906000165 Protein of unknown function (DUF2662); Region: DUF3662; pfam12401 443906000166 Forkhead associated domain (FHA); found in eukaryotic and prokaryotic proteins. Putative nuclear signalling domain. FHA domains may bind phosphothreonine, phosphoserine and sometimes phosphotyrosine. In eukaryotes, many FHA domain-containing proteins...; Region: FHA; cd00060 443906000167 FOG: FHA domain [Signal transduction mechanisms]; Region: COG1716 443906000168 phosphopeptide binding site; other site 443906000169 Uncharacterized conserved protein (DUF2156); Region: DUF2156; pfam09924 443906000170 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 443906000171 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 443906000172 active site 443906000173 phosphorylation site [posttranslational modification] 443906000174 intermolecular recognition site; other site 443906000175 dimerization interface [polypeptide binding]; other site 443906000176 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 443906000177 DNA binding residues [nucleotide binding] 443906000178 dimerization interface [polypeptide binding]; other site 443906000179 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: COG4585 443906000180 Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase; Region: HATPase_c; pfam02518 443906000181 50S ribosomal protein L36; Validated; Region: rpmJ; PRK00831 443906000182 Cobalamin synthesis protein cobW C-terminal domain; Region: CobW_C; pfam07683 443906000183 DEAD-like helicases superfamily; Region: DEXDc; smart00487 443906000184 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 443906000185 ATP binding site [chemical binding]; other site 443906000186 putative Mg++ binding site [ion binding]; other site 443906000187 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 443906000188 nucleotide binding region [chemical binding]; other site 443906000189 ATP-binding site [chemical binding]; other site 443906000190 Glutaminase [Amino acid transport and metabolism]; Region: GlsA; COG2066 443906000191 Glutaminase; Region: Glutaminase; cl00907 443906000192 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 443906000193 Predicted transcriptional regulators [Transcription]; Region: COG1695 443906000194 Transcriptional regulator PadR-like family; Region: PadR; pfam03551 443906000195 This domain superfamily is found in a variety of structurally related metalloproteins, including the type I extradiol dioxygenases, glyoxalase I and a group of antibiotic resistance proteins; Region: Glo_EDI_BRP_like; cd06587 443906000196 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 443906000197 active site 443906000198 Xylose isomerase-like TIM barrel; Region: AP_endonuc_2; pfam01261 443906000199 Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408 443906000200 Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673 443906000201 Transcriptional regulators [Transcription]; Region: PurR; COG1609 443906000202 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 443906000203 DNA binding site [nucleotide binding] 443906000204 domain linker motif; other site 443906000205 Ligand-binding domain of DNA transcription repressor LacI specific for lactose, a member of the LacI-GalR family of bacterial transcription regulators; Region: PBP1_LacI; cd01574 443906000206 ligand binding site [chemical binding]; other site 443906000207 dimerization interface (open form) [polypeptide binding]; other site 443906000208 dimerization interface (closed form) [polypeptide binding]; other site 443906000209 transcriptional regulator, LacI family, COG1609: Transcriptional Regulators; Family membership 443906000210 Trypsin-like serine protease; Many of these are synthesized as inactive precursor zymogens that are cleaved during limited proteolysis to generate their active forms. Alignment contains also inactive enzymes that have substitutions of the catalytic triad...; Region: Tryp_SPc; cl00149 443906000211 Pectate lyase; Region: Pectate_lyase; pfam03211 443906000212 Trypsin-like peptidase domain; Region: Trypsin_2; pfam13365 443906000213 Beta-glucosidase-related glycosidases [Carbohydrate transport and metabolism]; Region: BglX; COG1472 443906000214 Glycosyl hydrolase family 3 N terminal domain; Region: Glyco_hydro_3; pfam00933 443906000215 Glycosyl hydrolase family 3 C-terminal domain; Region: Glyco_hydro_3_C; pfam01915 443906000216 Pectate lyase; Region: Pectate_lyase; pfam03211 443906000217 Trypsin-like peptidase domain; Region: Trypsin_2; pfam13365 443906000218 Nucleotidyl transferase of unknown function (DUF1814); Region: DUF1814; pfam08843 443906000219 Domain of unknown function (DUF4095); Region: DUF4095; pfam13338 443906000220 Protein of unknown function (DUF3892); Region: DUF3892; pfam13031 443906000221 Fic/DOC family; Region: Fic; cl00960 443906000222 mobile mystery protein B; Region: mob_myst_B; TIGR02613 443906000223 Replication protein A, class 2b aminoacyl-tRNA synthetases, and related proteins with oligonucleotide/oligosaccharide (OB) fold; Region: RPA_2b-aaRSs_OBF_like; cl09930 443906000224 generic binding surface I; other site 443906000225 generic binding surface II; other site 443906000226 Protein of unknown function (DUF1524); Region: DUF1524; pfam07510 443906000227 Predicted hydrolase (HAD superfamily) [General function prediction only]; Region: COG1011 443906000228 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 443906000229 motif II; other site 443906000230 Phosphotransferase enzyme family; Region: APH; pfam01636 443906000231 Aminoglycoside 3'-phosphotransferase (APH) and Choline Kinase (ChoK) family. The APH/ChoK family is part of a larger superfamily that includes the catalytic domains of other kinases, such as the typical serine/threonine/tyrosine protein kinases (PKs)...; Region: APH_ChoK_like; cd05120 443906000232 active site 443906000233 ATP binding site [chemical binding]; other site 443906000234 ParA-like protein; Provisional; Region: PHA02518 443906000235 ParA and ParB of Caulobacter crescentus belong to a conserved family of bacterial proteins implicated in chromosome segregation. ParB binds to DNA sequences adjacent to the origin of replication and localizes to opposite cell poles shortly following the...; Region: ParA; cd02042 443906000236 P-loop; other site 443906000237 Magnesium ion binding site [ion binding]; other site 443906000238 AAA ATPase domain; Region: AAA_16; pfam13191 443906000239 AAA domain; Region: AAA_22; pfam13401 443906000240 Concanavalin A-like lectin/glucanases superfamily; Region: Laminin_G_3; pfam13385 443906000241 Na+/H+ antiporter 1; Region: Na_H_antiport_1; cl01133 443906000242 Peptidase inhibitor I9; Region: Inhibitor_I9; pfam05922 443906000243 Peptidase domain in the S8 and S53 families; Region: Peptidases_S8_S53; cl10459 443906000244 active site 443906000245 catalytic residues [active] 443906000246 PA_subtilisin_like: Protease-associated domain containing subtilisin-like proteases. This group contains various PA domain-containing subtilisin-like proteases including melon cucumisin, Arabidopsis thaliana Ara12, a nodule specific serine protease from...; Region: PA_subtilisin_like; cd02120 443906000247 PA/protease or protease-like domain interface [polypeptide binding]; other site 443906000248 Peptidase domain in the S8 and S53 families; Region: Peptidases_S8_S53; cl10459 443906000249 catalytic residues [active] 443906000250 Metallo-beta-lactamase superfamily; Region: Lactamase_B; smart00849 443906000251 long-chain-fatty-acid--CoA ligase; Validated; Region: PRK07656 443906000252 Prokaryotic long-chain fatty acid CoA synthetases similar to Escherichia coli FadD; Region: FC-FACS_FadD_like; cd05936 443906000253 acyl-activating enzyme (AAE) consensus motif; other site 443906000254 putative AMP binding site [chemical binding]; other site 443906000255 putative active site [active] 443906000256 putative CoA binding site [chemical binding]; other site 443906000257 Uncharacterized protein conserved in bacteria (DUF2188); Region: DUF2188; pfam09954 443906000258 Trypsin-like peptidase domain; Region: Trypsin_2; pfam13365 443906000259 CoA-disulfide reductase; Region: CoA_CoA_reduc; TIGR03385 443906000260 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 443906000261 Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain; Region: Pyr_redox_dim; pfam02852 443906000262 Member of the Rhodanese Homology Domain superfamily. Included in this CD are the Lactococcus lactis NADH oxidase, Bacillus cereus NADH dehydrogenase, and Bacteroides thetaiotaomicron pyridine nucleotide-disulphide oxidoreductase, and similar...; Region: RHOD_Pyr_redox; cd01524 443906000263 active site residue [active] 443906000264 Rhodanese Homology Domain (RHOD); an alpha beta fold domain found duplicated in the rhodanese protein. The cysteine containing enzymatically active version of the domain is also found in the Cdc25 class of protein phosphatases and a variety of proteins...; Region: RHOD; cd00158 443906000265 active site residue [active] 443906000266 Transcriptional regulators CsoR (copper-sensitive operon repressor), RcnR, and FrmR, and related domains; this domain superfamily was previously known as DUF156; Region: CsoR-like_DUF156; cd10148 443906000267 putative homodimer interface [polypeptide binding]; other site 443906000268 putative homotetramer interface [polypeptide binding]; other site 443906000269 putative allosteric switch controlling residues; other site 443906000270 putative metal binding site [ion binding]; other site 443906000271 putative homodimer-homodimer interface [polypeptide binding]; other site 443906000272 Dehydrogenases with different specificities (related to short-chain alcohol dehydrogenases) [Secondary metabolites biosynthesis, transport, and catabolism / General function prediction only]; Region: FabG; COG1028 443906000273 classical (c) SDRs; Region: SDR_c; cd05233 443906000274 NAD(P) binding site [chemical binding]; other site 443906000275 active site 443906000276 beta-D-glucoside glucohydrolase; Provisional; Region: PRK15098 443906000277 Glycosyl hydrolase family 3 N terminal domain; Region: Glyco_hydro_3; pfam00933 443906000278 Fibronectin type III-like domain; Region: Fn3-like; pfam14310 443906000279 Beta-glucosidase-related glycosidases [Carbohydrate transport and metabolism]; Region: BglX; COG1472 443906000280 Glycosyl hydrolase family 3 N terminal domain; Region: Glyco_hydro_3; cl07971 443906000281 ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395 443906000282 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 443906000283 dimer interface [polypeptide binding]; other site 443906000284 conserved gate region; other site 443906000285 putative PBP binding loops; other site 443906000286 ABC-ATPase subunit interface; other site 443906000287 ABC-type polysaccharide transport system, permease component [Carbohydrate transport and metabolism]; Region: LplB; COG4209 443906000288 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 443906000289 dimer interface [polypeptide binding]; other site 443906000290 conserved gate region; other site 443906000291 ABC-ATPase subunit interface; other site 443906000292 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; pfam01547 443906000293 Bacterial extracellular solute-binding protein; Region: SBP_bac_8; pfam13416 443906000294 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 443906000295 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 443906000296 Glycosyl hydrolase family 1; Region: Glyco_hydro_1; cl01046 443906000297 beta-galactosidase; Region: BGL; TIGR03356 443906000298 Transcriptional regulators [Transcription]; Region: PurR; COG1609 443906000299 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 443906000300 DNA binding site [nucleotide binding] 443906000301 domain linker motif; other site 443906000302 Ligand-binding domain of a LacI-like transcriptional regulator, CatR which is involved in catechol degradation; Region: PBP1_CatR_like; cd06296 443906000303 putative dimerization interface [polypeptide binding]; other site 443906000304 putative ligand binding site [chemical binding]; other site 443906000305 Glycosyl hydrolase family 10; Region: Glyco_10; smart00633 443906000306 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 443906000307 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 443906000308 active site 443906000309 phosphorylation site [posttranslational modification] 443906000310 intermolecular recognition site; other site 443906000311 dimerization interface [polypeptide binding]; other site 443906000312 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 443906000313 DNA binding residues [nucleotide binding] 443906000314 dimerization interface [polypeptide binding]; other site 443906000315 Histidine kinase; Region: HisKA_3; pfam07730 443906000316 Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase; Region: HATPase_c; pfam02518 443906000317 MMPL family; Region: MMPL; pfam03176 443906000318 Predicted drug exporters of the RND superfamily [General function prediction only]; Region: COG2409 443906000319 Cytochrome P450 [Secondary metabolites biosynthesis, transport, and catabolism]; Region: CypX; COG2124 443906000320 Cytochrome P450; Region: p450; cl12078 443906000321 4Fe-4S single cluster domain; Region: Fer4_13; pfam13370 443906000322 Protein of unknown function (DUF1271); Region: DUF1271; cl01443 443906000323 phenylpropionate dioxygenase ferredoxin reductase subunit; Provisional; Region: PRK09754 443906000324 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 443906000325 beta-D-glucoside glucohydrolase; Provisional; Region: PRK15098 443906000326 Glycosyl hydrolase family 3 N terminal domain; Region: Glyco_hydro_3; pfam00933 443906000327 Fibronectin type III-like domain; Region: Fn3-like; pfam14310 443906000328 Transcriptional regulators [Transcription]; Region: PurR; COG1609 443906000329 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 443906000330 DNA binding site [nucleotide binding] 443906000331 domain linker motif; other site 443906000332 Ligand binding domain of the LacI tanscriptional regulator family belonging to the type I periplasmic-binding fold protein superfamily; Region: PBP1_LacI_sugar_binding_like; cd06267 443906000333 ligand binding site [chemical binding]; other site 443906000334 dimerization interface [polypeptide binding]; other site 443906000335 Glycosyl hydrolases family 2, sugar binding domain; Region: Glyco_hydro_2_N; pfam02837 443906000336 Glycosyl hydrolases family 2; Region: Glyco_hydro_2; pfam00703 443906000337 Glycosyl hydrolases family 2, TIM barrel domain; Region: Glyco_hydro_2_C; pfam02836 443906000338 Beta-glucosidase-related glycosidases [Carbohydrate transport and metabolism]; Region: BglX; COG1472 443906000339 Glycosyl hydrolase family 3 N terminal domain; Region: Glyco_hydro_3; pfam00933 443906000340 Glycosyl hydrolase family 3 C-terminal domain; Region: Glyco_hydro_3_C; pfam01915 443906000341 Fibronectin type III-like domain; Region: Fn3-like; pfam14310 443906000342 Beta-glucosidase/6-phospho-beta-glucosidase/beta- galactosidase [Carbohydrate transport and metabolism]; Region: BglB; COG2723 443906000343 beta-galactosidase; Region: BGL; TIGR03356 443906000344 Glycosyl hydrolases family 35; Region: Glyco_hydro_35; pfam01301 443906000345 Glycosyl hydrolase family 43; Region: GH43_3; cd08982 443906000346 active site 443906000347 F5/8 type C domain; Region: F5_F8_type_C; pfam00754 443906000348 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 443906000349 Major Facilitator Superfamily; Region: MFS_1; pfam07690 443906000350 Alpha-L-rhamnosidase N-terminal domain; Region: Bac_rhamnosid_N; pfam08531 443906000351 Bacterial alpha-L-rhamnosidase; Region: Bac_rhamnosid; pfam05592 443906000352 putative alpha-glucosidase; Provisional; Region: PRK10658 443906000353 Galactose mutarotase-like; Region: Gal_mutarotas_2; pfam13802 443906000354 YicI alpha-xylosidase is a glycosyl hydrolase family 31 (GH31) enzyme that catalyzes the release of an alpha-xylosyl residue from the non-reducing end of alpha-xyloside substrates such as alpha-xylosyl fluoride and isoprimeverose. YicI forms a...; Region: GH31_xylosidase_YicI; cd06593 443906000355 active site 443906000356 homotrimer interface [polypeptide binding]; other site 443906000357 catalytic site [active] 443906000358 homohexamer (dimer of homotrimers) interface [polypeptide binding]; other site 443906000359 ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395 443906000360 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 443906000361 dimer interface [polypeptide binding]; other site 443906000362 conserved gate region; other site 443906000363 putative PBP binding loops; other site 443906000364 ABC-ATPase subunit interface; other site 443906000365 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 443906000366 dimer interface [polypeptide binding]; other site 443906000367 conserved gate region; other site 443906000368 putative PBP binding loops; other site 443906000369 ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395 443906000370 ABC-ATPase subunit interface; other site 443906000371 ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653 443906000372 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; pfam01547 443906000373 Beta-xylosidase [Carbohydrate transport and metabolism]; Region: XynB; COG3507 443906000374 Glycosyl hydrolase family 43, beta-D-xylosidase; Region: GH43_XYL_1; cd09000 443906000375 inhibitor binding site; inhibition site 443906000376 active site 443906000377 Xylose isomerase-like TIM barrel; Region: AP_endonuc_2; pfam01261 443906000378 Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408 443906000379 Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673 443906000380 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 443906000381 Putative lysophospholipase; Region: Hydrolase_4; pfam12146 443906000382 HEAT repeats; Region: HEAT_2; pfam13646 443906000383 Helix-Turn-Helix DNA binding domain of MerR-like transcription regulators; Region: HTH_MerR-like; cd00592 443906000384 Predicted transcriptional regulators [Transcription]; Region: SoxR; COG0789 443906000385 DNA binding residues [nucleotide binding] 443906000386 Dienelactone hydrolase family; Region: DLH; pfam01738 443906000387 Major Facilitator Superfamily; Region: MFS_1; pfam07690 443906000388 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 443906000389 putative substrate translocation pore; other site 443906000390 Tetracyclin repressor, C-terminal all-alpha domain; Region: TetR_C; pfam02909 443906000391 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 443906000392 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 443906000393 Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289 443906000394 urea carboxylase; Region: urea_carbox; TIGR02712 443906000395 ATP-grasp domain; Region: ATP-grasp_4; cl17255 443906000396 Biotin carboxylase C-terminal domain; Region: Biotin_carb_C; pfam02785 443906000397 Allophanate hydrolase subunit 2; Region: AHS2; smart00797 443906000398 Allophanate hydrolase subunit 1 [Amino acid transport and metabolism]; Region: DUR1; cl00896 443906000399 The biotinyl-domain or biotin carboxyl carrier protein (BCCP) domain is present in all biotin-dependent enzymes, such as acetyl-CoA carboxylase, pyruvate carboxylase, propionyl-CoA carboxylase, methylcrotonyl-CoA carboxylase, geranyl-CoA carboxylase; Region: biotinyl_domain; cd06850 443906000400 carboxyltransferase (CT) interaction site; other site 443906000401 biotinylation site [posttranslational modification]; other site 443906000402 urea carboxylase-associated protein 1; Region: urea_degr_1; TIGR03424 443906000403 Domain of unknown function (DUF1989); Region: DUF1989; pfam09347 443906000404 urea carboxylase-associated protein 2; Region: urea_degr_2; TIGR03425 443906000405 urea carboxylase-associated protein 1; Region: urea_degr_1; TIGR03424 443906000406 permease, urea carboxylase system; Region: ureacarb_perm; TIGR03428 443906000407 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 443906000408 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 443906000409 AMP binding site [chemical binding]; other site 443906000410 active site 443906000411 acyl-activating enzyme (AAE) consensus motif; other site 443906000412 CoA binding site [chemical binding]; other site 443906000413 Phosphopantetheine attachment site; Region: PKS_PP; smart00823 443906000414 Putative dehydrogenase domain of multifunctional non-ribosomal peptide synthetases and related enzymes [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG3320 443906000415 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 443906000416 NAD(P) binding site [chemical binding]; other site 443906000417 active site 443906000418 Phosphopantetheinyl transferase component of siderophore synthetase [Secondary metabolites biosynthesis, transport, and catabolism]; Region: EntD; COG2977 443906000419 RNA polymerase sigma factor SigL; Provisional; Region: PRK09645 443906000420 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 443906000421 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 443906000422 DNA binding residues [nucleotide binding] 443906000423 A domain in the BMP inhibitor chordin and in microbial proteins; Region: CHRD; smart00754 443906000424 Sortase E (SrtE) is a membrane transpeptidase found in gram-positive bacteria that cleaves surface proteins at a cell sorting motif and catalyzes a transpeptidation reaction in which the surface protein substrate is covalently linked to peptidoglycan for...; Region: Sortase_E; cd05829 443906000425 active site 443906000426 putative catalytic site [active] 443906000427 Pyroglutamyl peptidase (PGP) type I, also known as pyrrolidone carboxyl peptidase (pcp) type I: Enzymes responsible for cleaving pyroglutamate (pGlu) from the N-terminal end of specialized proteins. The N-terminal pGlu protects these proteins from...; Region: Peptidase_C15; cd00501 443906000428 putative substrate binding pocket [chemical binding]; other site 443906000429 AC domain interface; other site 443906000430 catalytic triad [active] 443906000431 AB domain interface; other site 443906000432 interchain disulfide; other site 443906000433 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases [Coenzyme metabolism / Energy production and conversion]; Region: UbiH; COG0654 443906000434 hypothetical protein; Provisional; Region: PRK07236 443906000435 ubiquinone biosynthesis hydroxylase family protein; Provisional; Region: PRK07608; cl17314 443906000436 Nucleotidyltransferase (NT) domain of RelA- and SpoT-like ppGpp synthetases and hydrolases; Region: NT_Rel-Spo_like; cd05399 443906000437 synthetase active site [active] 443906000438 NTP binding site [chemical binding]; other site 443906000439 metal binding site [ion binding]; metal-binding site 443906000440 37-kD nucleoid-associated bacterial protein; Region: NA37; pfam04245 443906000441 Vacuole effluxer Atg22 like; Region: ATG22; pfam11700 443906000442 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 443906000443 Phosphotransferase enzyme family; Region: APH; pfam01636 443906000444 Aminoglycoside 3'-phosphotransferase (APH) and Choline Kinase (ChoK) family. The APH/ChoK family is part of a larger superfamily that includes the catalytic domains of other kinases, such as the typical serine/threonine/tyrosine protein kinases (PKs)...; Region: APH_ChoK_like; cd05120 443906000445 substrate binding site [chemical binding]; other site 443906000446 Members of the Nudix hydrolase superfamily catalyze the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+, for their activity and contain a highly...; Region: Nudix_Hydrolase_23; cd04682 443906000447 nudix motif; other site 443906000448 MarR family; Region: MarR_2; cl17246 443906000449 The S26 Type I signal peptidase (SPase; LepB; leader peptidase B; leader peptidase I; EC 3.4.21.89) family members are essential membrane-bound serine proteases that function to cleave the amino-terminal signal peptide extension from proteins that are...; Region: S26_SPase_I; cd06530 443906000450 Catalytic site [active] 443906000451 Concanavalin A-like lectin/glucanases superfamily; Region: Laminin_G_3; pfam13385 443906000452 SnoaL-like domain; Region: SnoaL_2; pfam12680 443906000453 Nuclear transport factor 2 (NTF2-like) superfamily. This family includes members of the NTF2 family, Delta-5-3-ketosteroid isomerases, Scytalone Dehydratases, and the beta subunit of Ring hydroxylating dioxygenases. This family is a classic example of...; Region: NTF2_like; cl09109 443906000454 The S26 Type I signal peptidase (SPase; LepB; leader peptidase B; leader peptidase I; EC 3.4.21.89) family members are essential membrane-bound serine proteases that function to cleave the amino-terminal signal peptide extension from proteins that are...; Region: S26_SPase_I; cd06530 443906000455 Catalytic site [active] 443906000456 legume lectins; Region: lectin_L-type; cl14058 443906000457 homotetramer interaction site [polypeptide binding]; other site 443906000458 carbohydrate binding site [chemical binding]; other site 443906000459 metal binding site [ion binding]; metal-binding site 443906000460 molecular chaperone DnaK; Provisional; Region: dnaK; PRK00290 443906000461 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cl17037 443906000462 nucleotide binding site [chemical binding]; other site 443906000463 GrpE; Region: GrpE; pfam01025 443906000464 GrpE is the adenine nucleotide exchange factor of DnaK (Hsp70)-type ATPases. The GrpE dimer binds to the ATPase domain of Hsp70 catalyzing the dissociation of ADP, which enables rebinding of ATP, one step in the Hsp70 reaction cycle in protein folding; Region: GrpE; cd00446 443906000465 dimer interface [polypeptide binding]; other site 443906000466 hsp70 (ATPase domain) interactions [polypeptide binding]; other site 443906000467 DnaJ-class molecular chaperone [Posttranslational modification, protein turnover, chaperones]; Region: CbpA; COG2214 443906000468 DnaJ domain or J-domain. DnaJ/Hsp40 (heat shock protein 40) proteins are highly conserved and play crucial roles in protein translation, folding, unfolding, translocation, and degradation. They act primarily by stimulating the ATPase activity of Hsp70s; Region: DnaJ; cd06257 443906000469 HSP70 interaction site [polypeptide binding]; other site 443906000470 C-terminal substrate binding domain of DnaJ and HSP40; Region: DnaJ_C; cd10747 443906000471 dimer interface [polypeptide binding]; other site 443906000472 Helix-Turn-Helix DNA binding domain of the HspR transcription regulator; Region: HTH_HspR; cd04766 443906000473 DNA binding residues [nucleotide binding] 443906000474 MerR HTH family regulatory protein; Region: MerR_1; pfam13411 443906000475 putative dimer interface [polypeptide binding]; other site 443906000476 16S RNA G1207 methylase RsmC [Translation, ribosomal structure and biogenesis]; Region: RsmC; COG2813 443906000477 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 443906000478 S-adenosylmethionine binding site [chemical binding]; other site 443906000479 Domain of unknown function (DUF1905); Region: DUF1905; pfam08922 443906000480 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 443906000481 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 443906000482 non-specific DNA binding site [nucleotide binding]; other site 443906000483 salt bridge; other site 443906000484 sequence-specific DNA binding site [nucleotide binding]; other site 443906000485 Sensors of blue-light using FAD; Region: BLUF; pfam04940 443906000486 2'-5' RNA ligase superfamily; Region: 2_5_RNA_ligase2; pfam13563 443906000487 Transcriptional regulators [Transcription]; Region: PurR; COG1609 443906000488 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 443906000489 DNA binding site [nucleotide binding] 443906000490 domain linker motif; other site 443906000491 Ligand binding domain of the LacI tanscriptional regulator family belonging to the type I periplasmic-binding fold protein superfamily; Region: PBP1_LacI_sugar_binding_like; cd06267 443906000492 dimerization interface [polypeptide binding]; other site 443906000493 ligand binding site [chemical binding]; other site 443906000494 Conserved protein/domain typically associated with flavoprotein oxygenases, DIM6/NTAB family [General function prediction only]; Region: COG1853 443906000495 Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281 443906000496 SGNH_hydrolase, or GDSL_hydrolase, is a diverse family of lipases and esterases. The tertiary fold of the enzyme is substantially different from that of the alpha/beta hydrolase family and unique among all known hydrolases; its active site closely...; Region: SGNH_hydrolase; cl01053 443906000497 active site 443906000498 catalytic triad [active] 443906000499 oxyanion hole [active] 443906000500 ABC-type cobalamin/Fe3+-siderophores transport systems, ATPase components [Inorganic ion transport and metabolism / Coenzyme metabolism]; Region: FepC; COG1120 443906000501 ATP-binding component of iron-siderophores, vitamin B12 and hemin transporters and related proteins; Region: ABC_Iron-Siderophores_B12_Hemin; cd03214 443906000502 Walker A/P-loop; other site 443906000503 ATP binding site [chemical binding]; other site 443906000504 Q-loop/lid; other site 443906000505 ABC transporter signature motif; other site 443906000506 Walker B; other site 443906000507 D-loop; other site 443906000508 H-loop/switch region; other site 443906000509 Fe3+-siderophore binding domain FhuD. These proteins have been shown to function as initial receptors in ABC transport of Fe3+-siderophores in many eubacterial species. They belong to the TroA-like superfamily of helical backbone metal receptor proteins...; Region: FhuD; cd01146 443906000510 Periplasmic binding protein; Region: Peripla_BP_2; pfam01497 443906000511 siderophore binding site; other site 443906000512 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cl00462 443906000513 iron-hydroxamate transporter permease subunit; Provisional; Region: PRK10577 443906000514 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cl00462 443906000515 ABC-ATPase subunit interface; other site 443906000516 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550 443906000517 dimer interface [polypeptide binding]; other site 443906000518 putative PBP binding regions; other site 443906000519 ABC-ATPase subunit interface; other site 443906000520 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: COG4585 443906000521 Histidine kinase; Region: HisKA_3; pfam07730 443906000522 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 443906000523 ATP binding site [chemical binding]; other site 443906000524 Mg2+ binding site [ion binding]; other site 443906000525 G-X-G motif; other site 443906000526 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 443906000527 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 443906000528 DNA binding residues [nucleotide binding] 443906000529 4-Oxalocrotonate Tautomerase: Catalyzes the isomerization of unsaturated ketones. The structure is a homohexamer that is arranged as a trimer of dimers. The hexamer contains six active sites, each formed by residues from three monomers, two from one...; Region: 4Oxalocrotonate_Tautomerase; cl00235 443906000530 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 443906000531 Coenzyme A binding pocket [chemical binding]; other site 443906000532 mRNA degradation ribonucleases J1/J2 (metallo-beta-lactamase superfamily) [Translation, ribosomal structure and biogenesis; Replication, recombination and repair]; Region: COG0595 443906000533 Metallo-beta-lactamase superfamily; Region: Lactamase_B; smart00849 443906000534 RNA-metabolising metallo-beta-lactamase; Region: RMMBL; pfam07521 443906000535 Sulfate permease and related transporters (MFS superfamily) [Inorganic ion transport and metabolism]; Region: SUL1; COG0659 443906000536 Sulfate transporter N-terminal domain with GLY motif; Region: Sulfate_tra_GLY; pfam13792 443906000537 Sulfate transporter family; Region: Sulfate_transp; pfam00916 443906000538 Sulphate Transporter and Anti-Sigma factor antagonist domain of SulP-like sulfate transporters, plays a role in the function and regulation of the transport activity, proposed general NTP binding function; Region: STAS_SulP_like_sulfate_transporter; cd07042 443906000539 heme ABC exporter, ATP-binding protein CcmA; Region: ccmA; TIGR01189 443906000540 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 443906000541 Walker A/P-loop; other site 443906000542 ATP binding site [chemical binding]; other site 443906000543 Q-loop/lid; other site 443906000544 ABC transporter signature motif; other site 443906000545 Walker B; other site 443906000546 D-loop; other site 443906000547 H-loop/switch region; other site 443906000548 ABC-type Mn2+/Zn2+ transport systems, permease components [Inorganic ion transport and metabolism]; Region: ZnuB; COG1108 443906000549 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cl00462 443906000550 ABC-ATPase subunit interface; other site 443906000551 dimer interface [polypeptide binding]; other site 443906000552 Helical backbone metal receptor (TroA-like domain). These proteins have been shown to function in the ABC transport of ferric siderophores and metal ions such as Mn2+, Fe3+, Cu2+ and/or Zn2+. Their ligand binding site is formed in the interface between...; Region: TroA-like; cl00262 443906000553 Periplasmic solute binding protein family; Region: SBP_bac_9; pfam01297 443906000554 intersubunit interface [polypeptide binding]; other site 443906000555 PQQ-dependent catabolism-associated beta-propeller protein; Region: PQQ_ABC_repeats; TIGR03866 443906000556 NAD-dependent aldehyde dehydrogenases [Energy production and conversion]; Region: PutA; COG1012 443906000557 Mycobacterium tuberculosis succinate-semialdehyde dehydrogenase 1-like; Region: ALDH_SSADH1_GabD1; cd07100 443906000558 NAD(P) binding site [chemical binding]; other site 443906000559 catalytic residues [active] 443906000560 This family includes the Gtfs, a group of homologous glycosyltransferases involved in the final stages of the biosynthesis of antibiotics vancomycin and related chloroeremomycin. Gtfs transfer sugar moieties from an activated NDP-sugar donor to the...; Region: GT1_Gtf_like; cd03784 443906000561 Glycosyl transferases, related to UDP-glucuronosyltransferase [Carbohydrate transport and metabolism / Signal transduction mechanisms]; Region: COG1819 443906000562 active site 443906000563 TDP-binding site; other site 443906000564 acceptor substrate-binding pocket; other site 443906000565 homodimer interface [polypeptide binding]; other site 443906000566 Bifunctional PLP-dependent enzyme with beta-cystathionase and maltose regulon repressor activities [Amino acid transport and metabolism]; Region: MalY; COG1168 443906000567 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 443906000568 pyridoxal 5'-phosphate binding site [chemical binding]; other site 443906000569 homodimer interface [polypeptide binding]; other site 443906000570 catalytic residue [active] 443906000571 CIMS - Cobalamine-independent methonine synthase, or MetE, C-terminal domain_like. Many members have been characterized as 5-methyltetrahydropteroyltriglutamate-homocysteine methyltransferases, EC:2.1.1.14, mostly from bacteria and plants. This enzyme...; Region: CIMS_C_terminal_like; cd03311 443906000572 substrate binding site [chemical binding]; other site 443906000573 THF binding site; other site 443906000574 zinc-binding site [ion binding]; other site 443906000575 O-acetylhomoserine sulfhydrylase [Amino acid transport and metabolism]; Region: MET17; COG2873 443906000576 CGS_like: Cystathionine gamma-synthase is a PLP dependent enzyme and catalyzes the committed step of methionine biosynthesis. This pathway is unique to microorganisms and plants, rendering the enzyme an attractive target for the development of...; Region: CGS_like; cd00614 443906000577 homodimer interface [polypeptide binding]; other site 443906000578 substrate-cofactor binding pocket; other site 443906000579 pyridoxal 5'-phosphate binding site [chemical binding]; other site 443906000580 catalytic residue [active] 443906000581 Flavin-utilizing monoxygenases; Region: Flavin_utilizing_monoxygenases; cl07892 443906000582 FMN-dependent oxidoreductase, nitrilotriacetate monooxygenase family; Region: FMN_nitrolo; TIGR03860 443906000583 mycofactocin system transcriptional regulator; Region: mycofact_TetR; TIGR03968 443906000584 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 443906000585 drug resistance transporter, EmrB/QacA subfamily; Region: efflux_EmrB; TIGR00711 443906000586 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 443906000587 putative substrate translocation pore; other site 443906000588 Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596 443906000589 Putative lysophospholipase; Region: Hydrolase_4; pfam12146 443906000590 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 443906000591 WHG domain; Region: WHG; pfam13305 443906000592 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 443906000593 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 443906000594 Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408 443906000595 Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673 443906000596 ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653 443906000597 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 443906000598 dimer interface [polypeptide binding]; other site 443906000599 ABC-ATPase subunit interface; other site 443906000600 putative PBP binding loops; other site 443906000601 ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395 443906000602 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 443906000603 dimer interface [polypeptide binding]; other site 443906000604 conserved gate region; other site 443906000605 putative PBP binding loops; other site 443906000606 ABC-ATPase subunit interface; other site 443906000607 Glycosyl hydrolases family 2, sugar binding domain; Region: Glyco_hydro_2_N; pfam02837 443906000608 Glycosyl hydrolases family 2; Region: Glyco_hydro_2; pfam00703 443906000609 Glycosyl hydrolases family 2, TIM barrel domain; Region: Glyco_hydro_2_C; pfam02836 443906000610 Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673 443906000611 Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408 443906000612 Oxidoreductase family, C-terminal alpha/beta domain; Region: GFO_IDH_MocA_C; pfam02894 443906000613 Predicted drug exporters of the RND superfamily [General function prediction only]; Region: COG2409 443906000614 Predicted drug exporters of the RND superfamily [General function prediction only]; Region: COG2409 443906000615 Predicted drug exporters of the RND superfamily [General function prediction only]; Region: COG2409 443906000616 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 443906000617 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 443906000618 Lipase. Lipases are esterases that can hydrolyze long-chain acyl-triglycerides into di- and monoglycerides, glycerol, and free fatty acids at a water/lipid interface. A typical feature of lipases is "interfacial activation", the process of...; Region: Lipase; cl14883 443906000619 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 443906000620 nucleophilic elbow; other site 443906000621 catalytic triad; other site 443906000622 3-hydroxybutyryl-CoA dehydrogenase; Validated; Region: PRK08293 443906000623 3-hydroxyacyl-CoA dehydrogenase, NAD binding domain; Region: 3HCDH_N; pfam02737 443906000624 3-hydroxyacyl-CoA dehydrogenase, C-terminal domain; Region: 3HCDH; pfam00725 443906000625 NADPH-dependent FMN reductase; Region: FMN_red; pfam03358 443906000626 Multimeric flavodoxin WrbA [General function prediction only]; Region: WrbA; COG0655 443906000627 PAP2_like_2 proteins. PAP2 is a super-family of phosphatases and haloperoxidases. This subgroup, which is specific to bacteria, lacks functional characterization and may act as a membrane-associated lipid phosphatase; Region: PAP2_like_2; cd03392 443906000628 active site 443906000629 Membrane-associated phospholipid phosphatase [Lipid metabolism]; Region: PgpB; COG0671 443906000630 hypothetical protein; Provisional; Region: PRK09256 443906000631 probable oxidoreductase, LLM family; Region: LLM_2I7G; TIGR03858 443906000632 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases [Energy production and conversion]; Region: COG2141 443906000633 Antitoxin Phd_YefM, type II toxin-antitoxin system; Region: PhdYeFM_antitox; cl09153 443906000634 Uncharacterized protein conserved in bacteria (DUF2200); Region: DUF2200; pfam09966 443906000635 Protein of unknown function (DUF2283); Region: DUF2283; pfam10049 443906000636 mycofactocin system transcriptional regulator; Region: mycofact_TetR; TIGR03968 443906000637 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 443906000638 enoyl_reductase_like; Region: enoyl_reductase_like; cd08249 443906000639 NADPH:quinone reductase and related Zn-dependent oxidoreductases [Energy production and conversion / General function prediction only]; Region: Qor; COG0604 443906000640 NAD(P) binding site [chemical binding]; other site 443906000641 Rhodanese Homology Domain (RHOD); an alpha beta fold domain found duplicated in the rhodanese protein. The cysteine containing enzymatically active version of the domain is also found in the Cdc25 class of protein phosphatases and a variety of proteins...; Region: RHOD; cd00158 443906000642 active site residue [active] 443906000643 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4430 443906000644 Bacteriocin-protection, YdeI or OmpD-Associated; Region: OmdA; pfam13376 443906000645 Membrane transporters of cations and cationic drugs [Inorganic ion transport and metabolism]; Region: EmrE; COG2076 443906000646 Small Multidrug Resistance protein; Region: Multi_Drug_Res; cl00910 443906000647 beta-phosphoglucomutase family hydrolase; Region: PGMB-YQAB-SF; TIGR02009 443906000648 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 443906000649 motif II; other site 443906000650 This family includes the Gtfs, a group of homologous glycosyltransferases involved in the final stages of the biosynthesis of antibiotics vancomycin and related chloroeremomycin. Gtfs transfer sugar moieties from an activated NDP-sugar donor to the...; Region: GT1_Gtf_like; cd03784 443906000651 glycosyltransferase, MGT family; Region: MGT; TIGR01426 443906000652 active site 443906000653 TDP-binding site; other site 443906000654 acceptor substrate-binding pocket; other site 443906000655 N-methyltryptophan oxidase; Provisional; Region: solA; PRK11259 443906000656 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450 443906000657 Acetyl xylan esterase (AXE1); Region: AXE1; pfam05448 443906000658 Prolyl oligopeptidase family; Region: Peptidase_S9; pfam00326 443906000659 TetR family transcriptional regulator; Provisional; Region: PRK14996 443906000660 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 443906000661 Bacterial transcriptional repressor; Region: TetR_C_6; pfam13977 443906000662 X-Pro dipeptidyl-peptidase (S15 family); Region: Peptidase_S15; pfam02129 443906000663 Prolyl oligopeptidase family; Region: Peptidase_S9; pfam00326 443906000664 X-Pro dipeptidyl-peptidase C-terminal non-catalytic domain; Region: PepX_C; smart00939 443906000665 ATPase components of various ABC-type transport systems, contain duplicated ATPase [General function prediction only]; Region: COG1123 443906000666 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 443906000667 Walker A/P-loop; other site 443906000668 ATP binding site [chemical binding]; other site 443906000669 Q-loop/lid; other site 443906000670 ABC transporter signature motif; other site 443906000671 Walker B; other site 443906000672 D-loop; other site 443906000673 H-loop/switch region; other site 443906000674 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097 443906000675 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 443906000676 Walker A/P-loop; other site 443906000677 ATP binding site [chemical binding]; other site 443906000678 Q-loop/lid; other site 443906000679 ABC transporter signature motif; other site 443906000680 Walker B; other site 443906000681 D-loop; other site 443906000682 H-loop/switch region; other site 443906000683 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097 443906000684 nickel ABC transporter, permease subunit NikC; Region: nickel_nikC; TIGR02790 443906000685 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 443906000686 dimer interface [polypeptide binding]; other site 443906000687 conserved gate region; other site 443906000688 putative PBP binding loops; other site 443906000689 ABC-ATPase subunit interface; other site 443906000690 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppB; COG0601 443906000691 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 443906000692 ABC-ATPase subunit interface; other site 443906000693 ABC-type dipeptide transport system, periplasmic component [Amino acid transport and metabolism]; Region: DdpA; COG0747 443906000694 The substrate-binding component of an uncharacterized ABC-type nickel/dipeptide/oligopeptide-like import system contains the type 2 periplasmic binding fold; Region: PBP2_NikA_DppA_OppA_like_17; cd08503 443906000695 Amino acid transporters [Amino acid transport and metabolism]; Region: PotE; COG0531 443906000696 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 443906000697 Major Facilitator Superfamily; Region: MFS_1; pfam07690 443906000698 short chain dehydrogenase; Provisional; Region: PRK06180 443906000699 17beta hydroxysteroid dehydrogenase-like, classical (c) SDRs; Region: 17beta-HSD-like_SDR_c; cd05374 443906000700 NADP binding site [chemical binding]; other site 443906000701 active site 443906000702 steroid binding site; other site 443906000703 Methylated DNA-protein cysteine methyltransferase [DNA replication, recombination, and repair]; Region: Ada; COG0350 443906000704 6-O-methylguanine DNA methyltransferase, ribonuclease-like domain; Region: Methyltransf_1N; pfam02870 443906000705 The DNA repair protein O6-alkylguanine-DNA alkyltransferase (ATase; also known as AGT, AGAT and MGMT) reverses O6-alkylation DNA damage by transferring O6-alkyl adducts to an active site cysteine irreversibly, without inducing DNA strand breaks. ATases...; Region: ATase; cd06445 443906000706 DNA binding site [nucleotide binding] 443906000707 active site 443906000708 RNA polymerase sigma factor, sigma-70 family; Region: sigma70-ECF; TIGR02937 443906000709 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 443906000710 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 443906000711 DNA binding residues [nucleotide binding] 443906000712 Response regulator receiver domain; Region: Response_reg; pfam00072 443906000713 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 443906000714 active site 443906000715 phosphorylation site [posttranslational modification] 443906000716 intermolecular recognition site; other site 443906000717 dimerization interface [polypeptide binding]; other site 443906000718 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cl17355 443906000719 Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673 443906000720 Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408 443906000721 Oxidoreductase family, C-terminal alpha/beta domain; Region: GFO_IDH_MocA_C; pfam02894 443906000722 Reeler-like domain of YcnI and similar proteins; Region: YcnI_like; cd08545 443906000723 Uncharacterized iron-regulated membrane protein [Function unknown]; Region: PiuB; COG3182 443906000724 PepSY-associated TM helix; Region: PepSY_TM_2; pfam13703 443906000725 Transcriptional regulators [Transcription]; Region: PurR; COG1609 443906000726 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 443906000727 DNA binding site [nucleotide binding] 443906000728 domain linker motif; other site 443906000729 Ligand binding domain of the LacI tanscriptional regulator family belonging to the type I periplasmic-binding fold protein superfamily; Region: PBP1_LacI_sugar_binding_like; cd06267 443906000730 dimerization interface [polypeptide binding]; other site 443906000731 ligand binding site [chemical binding]; other site 443906000732 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 443906000733 Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013 443906000734 Domain of unknown function (DUF4287); Region: DUF4287; pfam14117 443906000735 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 443906000736 Major Facilitator Superfamily; Region: MFS_1; pfam07690 443906000737 putative substrate translocation pore; other site 443906000738 Predicted NAD/FAD-binding protein [General function prediction only]; Region: COG2907 443906000739 Helix-Turn-Helix DNA binding domain of transcription regulators from the MerR superfamily; Region: HTH_MerR-SF; cl02600 443906000740 MerR HTH family regulatory protein; Region: MerR_1; pfam13411 443906000741 DNA binding residues [nucleotide binding] 443906000742 YdcF-like. YdcF-like is a large family of mainly bacterial proteins, with a few members found in fungi, plants, and archaea. Escherichia coli YdcF has been shown to bind S-adenosyl-L-methionine (AdoMet), but a biochemical function has not been...; Region: YdcF-like; cd06259 443906000743 putative active site [active] 443906000744 CrcB-like protein; Region: CRCB; pfam02537 443906000745 Integral membrane protein possibly involved in chromosome condensation [Cell division and chromosome partitioning]; Region: CrcB; COG0239 443906000746 Acetyltransferase (GNAT) domain; Region: Acetyltransf_7; pfam13508 443906000747 ADP-ribose pyrophosphatase (ADPRase) catalyzes the hydrolysis of ADP-ribose and a variety of additional ADP-sugar conjugates to AMP and ribose-5-phosphate. Like other members of the Nudix hydrolase superfamily, it requires a divalent cation, such as Mg2+; Region: ADPRase_NUDT5; cd03424 443906000748 ADP-ribose binding site [chemical binding]; other site 443906000749 dimer interface [polypeptide binding]; other site 443906000750 active site 443906000751 nudix motif; other site 443906000752 metal binding site [ion binding]; metal-binding site 443906000753 D-alanine--D-alanine ligase; Reviewed; Region: ddl; PRK01372 443906000754 D-ala D-ala ligase N-terminus; Region: Dala_Dala_lig_N; pfam01820 443906000755 ATP-grasp domain; Region: ATP-grasp_4; cl17255 443906000756 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 443906000757 RibD C-terminal domain; Region: RibD_C; cl17279 443906000758 Protein of unknown function (DUF3100); Region: DUF3100; pfam11299 443906000759 Transcriptional regulators [Transcription]; Region: RpiR; COG1737 443906000760 Helix-turn-helix domain, rpiR family; Region: HTH_6; pfam01418 443906000761 RpiR-like protein. RpiR contains a SIS (Sugar ISomerase) domain, which is found in many phosphosugar isomerases and phosphosugar binding proteins. In E. coli, rpiR negatively regulates the expression of rpiB gene. Both rpiB and rpiA are ribose phosphate...; Region: SIS_RpiR; cd05013 443906000762 putative active site [active] 443906000763 3-hydroxyisobutyrate dehydrogenase and related beta-hydroxyacid dehydrogenases [Lipid metabolism]; Region: MmsB; COG2084 443906000764 6-phosphogluconate dehydrogenase-like protein; Reviewed; Region: PRK09599 443906000765 Aldehyde dehydrogenase family; Region: Aldedh; pfam00171 443906000766 NAD(P)+-dependent aldehyde dehydrogenase superfamily; Region: ALDH-SF; cl11961 443906000767 NAD(P) binding site [chemical binding]; other site 443906000768 catalytic residues [active] 443906000769 Bacterial extracellular solute-binding protein; Region: SBP_bac_8; pfam13416 443906000770 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; pfam01547 443906000771 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 443906000772 dimer interface [polypeptide binding]; other site 443906000773 conserved gate region; other site 443906000774 putative PBP binding loops; other site 443906000775 ABC-ATPase subunit interface; other site 443906000776 ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395 443906000777 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 443906000778 dimer interface [polypeptide binding]; other site 443906000779 conserved gate region; other site 443906000780 putative PBP binding loops; other site 443906000781 ABC-ATPase subunit interface; other site 443906000782 Type 1 glutamine amidotransferase (GATase1)-like domain; Region: GAT_1; cl00020 443906000783 conserved cys residue [active] 443906000784 Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673 443906000785 Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408 443906000786 Oxidoreductase family, C-terminal alpha/beta domain; Region: GFO_IDH_MocA_C; pfam02894 443906000787 Transcriptional regulator/sugar kinase [Transcription / Carbohydrate transport and metabolism]; Region: NagC; COG1940 443906000788 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cl17037 443906000789 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cl17037 443906000790 Predicted phosphatase/phosphohexomutase [General function prediction only]; Region: COG0637 443906000791 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 443906000792 motif II; other site 443906000793 Chorismate mutase type II; Region: CM_2; cl00693 443906000794 hypothetical protein; Provisional; Region: PRK02237 443906000795 Acetyltransferase (GNAT) domain; Region: Acetyltransf_7; pfam13508 443906000796 AAA domain; Region: AAA_17; pfam13207 443906000797 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 443906000798 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 443906000799 HIT family: HIT (Histidine triad) proteins, named for a motif related to the sequence HxHxH/Qxx (x, a hydrophobic amino acid), are a superfamily of nucleotide hydrolases and transferases, which act on the alpha-phosphate of ribonucleotides. On the basis...; Region: HIT_like; cl00228 443906000800 nucleotide binding site/active site [active] 443906000801 HIT family signature motif; other site 443906000802 catalytic residue [active] 443906000803 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 443906000804 NAD(P) binding site [chemical binding]; other site 443906000805 active site 443906000806 YceI-like domain; Region: YceI; pfam04264 443906000807 RNA polymerase sigma factor SigL; Provisional; Region: PRK09645 443906000808 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 443906000809 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cl17257 443906000810 DNA binding residues [nucleotide binding] 443906000811 Putative zinc-finger; Region: zf-HC2; pfam13490 443906000812 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 443906000813 H+ Antiporter protein; Region: 2A0121; TIGR00900 443906000814 putative substrate translocation pore; other site 443906000815 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cl02429 443906000816 Tetratrico peptide repeat; Region: TPR_5; pfam12688 443906000817 binding surface 443906000818 TPR motif; other site 443906000819 Transcriptional regulators [Transcription]; Region: PurR; COG1609 443906000820 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 443906000821 DNA binding site [nucleotide binding] 443906000822 domain linker motif; other site 443906000823 Ligand-binding domain of a LacI-like transcriptional regulator, CatR which is involved in catechol degradation; Region: PBP1_CatR_like; cd06296 443906000824 putative dimerization interface [polypeptide binding]; other site 443906000825 putative ligand binding site [chemical binding]; other site 443906000826 ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653 443906000827 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; pfam01547 443906000828 ABC-type spermidine/putrescine transport system, permease component II [Amino acid transport and metabolism]; Region: PotC; COG1177 443906000829 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 443906000830 dimer interface [polypeptide binding]; other site 443906000831 conserved gate region; other site 443906000832 putative PBP binding loops; other site 443906000833 ABC-ATPase subunit interface; other site 443906000834 ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395 443906000835 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 443906000836 dimer interface [polypeptide binding]; other site 443906000837 conserved gate region; other site 443906000838 putative PBP binding loops; other site 443906000839 ABC-ATPase subunit interface; other site 443906000840 beta-D-glucoside glucohydrolase; Provisional; Region: PRK15098 443906000841 Glycosyl hydrolase family 3 N terminal domain; Region: Glyco_hydro_3; pfam00933 443906000842 Fibronectin type III-like domain; Region: Fn3-like; pfam14310 443906000843 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 443906000844 NmrA-like family; Region: NmrA; pfam05368 443906000845 NAD(P) binding site [chemical binding]; other site 443906000846 active site 443906000847 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 443906000848 Helix-turn-helix domain; Region: HTH_31; pfam13560 443906000849 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 443906000850 Dehydrogenases with different specificities (related to short-chain alcohol dehydrogenases) [Secondary metabolites biosynthesis, transport, and catabolism / General function prediction only]; Region: FabG; COG1028 443906000851 NAD(P) binding site [chemical binding]; other site 443906000852 active site 443906000853 Acetyltransferase (GNAT) domain; Region: Acetyltransf_3; pfam13302 443906000854 Beta-lactamase; Region: Beta-lactamase; pfam00144 443906000855 Beta-lactamase class C and other penicillin binding proteins [Defense mechanisms]; Region: AmpC; COG1680 443906000856 Rhodanese Homology Domain (RHOD); an alpha beta fold domain found duplicated in the rhodanese protein. The cysteine containing enzymatically active version of the domain is also found in the Cdc25 class of protein phosphatases and a variety of proteins...; Region: RHOD; cl00125 443906000857 active site residue [active] 443906000858 AAA ATPase domain; Region: AAA_16; pfam13191 443906000859 Nucleoside/nucleotide kinase (NK) is a protein superfamily consisting of multiple families of enzymes that share structural similarity and are functionally related to the catalysis of the reversible phosphate group transfer from nucleoside triphosphates...; Region: NK; cl17190 443906000860 active site 443906000861 Alpha-L-arabinofuranosidase [Carbohydrate transport and metabolism]; Region: AbfA; COG3534 443906000862 Alpha-L-arabinofuranosidase C-terminus; Region: Alpha-L-AF_C; pfam06964 443906000863 Acetyltransferases, including N-acetylases of ribosomal proteins [Translation, ribosomal structure and biogenesis]; Region: RimL; COG1670 443906000864 Acetyltransferase (GNAT) family; Region: Acetyltransf_1; pfam00583 443906000865 Cobalamin synthesis protein cobW C-terminal domain; Region: CobW_C; smart00833 443906000866 Thioredoxin reductase [Posttranslational modification, protein turnover, chaperones]; Region: TrxB; COG0492 443906000867 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 443906000868 ATPases associated with a variety of cellular activities; Region: AAA; smart00382 443906000869 Walker A motif; other site 443906000870 ATP binding site [chemical binding]; other site 443906000871 Walker B motif; other site 443906000872 arginine finger; other site 443906000873 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 443906000874 ATPases associated with a variety of cellular activities; Region: AAA; smart00382 443906000875 Walker A motif; other site 443906000876 ATP binding site [chemical binding]; other site 443906000877 Walker B motif; other site 443906000878 arginine finger; other site 443906000879 C-terminal, D2-small domain, of ClpB protein; Region: ClpB_D2-small; pfam10431 443906000880 Melibiase; Region: Melibiase; pfam02065 443906000881 uncharacterized Actinobacterial protein TIGR03083; Region: TIGR03083 443906000882 Mycothiol maleylpyruvate isomerase N-terminal domain; Region: MDMPI_N; pfam11716 443906000883 hydroxymethylglutaryl-CoA synthase; Region: PLN02577 443906000884 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 443906000885 Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248 443906000886 active site 443906000887 catalytic tetrad [active] 443906000888 renal dipeptidase (rDP), best studied in mammals and also called membrane or microsomal dipeptidase, is a membrane-bound glycoprotein hydrolyzing dipeptides and is involved in hydrolytic metabolism of penem and carbapenem beta-lactam antibiotics; Region: rDP_like; cd01301 443906000889 active site 443906000890 Zn-dependent dipeptidase, microsomal dipeptidase homolog [Amino acid transport and metabolism]; Region: COG2355 443906000891 dimer interface [polypeptide binding]; other site 443906000892 Acetyltransferase (GNAT) family; Region: Acetyltransf_1; pfam00583 443906000893 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 443906000894 ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136 443906000895 Walker A/P-loop; other site 443906000896 ATP binding site [chemical binding]; other site 443906000897 Q-loop/lid; other site 443906000898 ABC transporter signature motif; other site 443906000899 Walker B; other site 443906000900 D-loop; other site 443906000901 H-loop/switch region; other site 443906000902 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 443906000903 ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136 443906000904 Walker A/P-loop; other site 443906000905 ATP binding site [chemical binding]; other site 443906000906 Q-loop/lid; other site 443906000907 ABC transporter signature motif; other site 443906000908 Walker B; other site 443906000909 D-loop; other site 443906000910 H-loop/switch region; other site 443906000911 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 443906000912 S-adenosylmethionine binding site [chemical binding]; other site 443906000913 Thioesterase domain; Region: Thioesterase; pfam00975 443906000914 thiazolinyl imide reductase; Region: thiaz-red; TIGR01761 443906000915 Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408 443906000916 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 443906000917 S-adenosylmethionine binding site [chemical binding]; other site 443906000918 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 443906000919 NAD(P) binding site [chemical binding]; other site 443906000920 Condensation domain; Region: Condensation; pfam00668 443906000921 Nonribosomal peptide synthase; Region: NRPS; pfam08415 443906000922 The adenylation domain of nonribosomal peptide synthetases (NRPS), including Streptoalloteichus tallysomycin biosynthesis genes; Region: A_NRPS_TlmIV_like; cd12114 443906000923 amino acid adenylation domain; Region: AA-adenyl-dom; TIGR01733 443906000924 acyl-activating enzyme (AAE) consensus motif; other site 443906000925 AMP binding site [chemical binding]; other site 443906000926 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 443906000927 S-adenosylmethionine binding site [chemical binding]; other site 443906000928 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 443906000929 Phosphopantetheine attachment site; Region: PP-binding; pfam00550 443906000930 Thioesterase domains of type I polyketide synthases or non-ribosomal peptide synthetases [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG3319 443906000931 Phosphopantetheine attachment site; Region: PP-binding; cl09936 443906000932 Nonribosomal peptide synthase; Region: NRPS; pfam08415 443906000933 The adenylation domain of nonribosomal peptide synthetases (NRPS), including Streptoalloteichus tallysomycin biosynthesis genes; Region: A_NRPS_TlmIV_like; cd12114 443906000934 amino acid adenylation domain; Region: AA-adenyl-dom; TIGR01733 443906000935 acyl-activating enzyme (AAE) consensus motif; other site 443906000936 AMP binding site [chemical binding]; other site 443906000937 Phosphopantetheine attachment site; Region: PP-binding; pfam00550 443906000938 Condensation domain; Region: Condensation; pfam00668 443906000939 Non-ribosomal peptide synthetase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: EntF; COG1020 443906000940 Nonribosomal peptide synthase; Region: NRPS; pfam08415 443906000941 The adenylation domain of nonribosomal peptide synthetases (NRPS), including Streptoalloteichus tallysomycin biosynthesis genes; Region: A_NRPS_TlmIV_like; cd12114 443906000942 acyl-activating enzyme (AAE) consensus motif; other site 443906000943 AMP binding site [chemical binding]; other site 443906000944 Phosphopantetheine attachment site; Region: PP-binding; pfam00550 443906000945 Peptide arylation enzymes [Secondary metabolites biosynthesis, transport, and catabolism]; Region: EntE; COG1021 443906000946 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 443906000947 acyl-activating enzyme (AAE) consensus motif; other site 443906000948 AMP binding site [chemical binding]; other site 443906000949 active site 443906000950 CoA binding site [chemical binding]; other site 443906000951 4'-phosphopantetheinyl transferase superfamily; Region: ACPS; pfam01648 443906000952 chorismate binding enzyme; Region: Chorismate_bind; pfam00425 443906000953 Predicted membrane protein (DUF2207); Region: DUF2207; pfam09972 443906000954 Predicted membrane protein (DUF2207); Region: DUF2207; pfam09972 443906000955 Beta-lactamase enzyme family; Region: Beta-lactamase2; pfam13354 443906000956 BacA is a bacterial lysin from Enterococcus faecalis that degrades bacterial cell walls by catalyzing the hydrolysis of 1,4-beta-linkages between N-acetylmuramic acid and N-acetyl-D-glucosamine residues. BacA is homologous to the YbfG and YkuG lysins of...; Region: GH25_BacA-like; cd06418 443906000957 active site 443906000958 Asp23 family; Region: Asp23; pfam03780 443906000959 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 443906000960 Ferritin-like domain; Region: Ferritin_2; pfam13668 443906000961 N-terminal catalytic domain of endoplasmic reticulum(ER)/cytosolic class II alpha-mannosidases; glycoside hydrolase family 38 (GH38); Region: GH38N_AMII_ER_cytosolic; cd10789 443906000962 active site 443906000963 catalytic site [active] 443906000964 Alpha mannosidase, middle domain; Region: Alpha-mann_mid; pfam09261 443906000965 Glycosyl hydrolases family 38 C-terminal domain; Region: Glyco_hydro_38C; pfam07748 443906000966 Glycoside Hydrolases Family 4; Phospho-beta-glucosidase; Region: GH4_P_beta_glucosidase; cd05296 443906000967 Alpha-galactosidases/6-phospho-beta-glucosidases, family 4 of glycosyl hydrolases [Carbohydrate transport and metabolism]; Region: CelF; COG1486 443906000968 NAD binding site [chemical binding]; other site 443906000969 sugar binding site [chemical binding]; other site 443906000970 divalent metal binding site [ion binding]; other site 443906000971 tetramer (dimer of dimers) interface [polypeptide binding]; other site 443906000972 dimer interface [polypeptide binding]; other site 443906000973 Transcriptional regulators of sugar metabolism [Transcription / Carbohydrate transport and metabolism]; Region: GlpR; COG1349 443906000974 DeoR-like helix-turn-helix domain; Region: HTH_DeoR; pfam08220 443906000975 DeoR C terminal sensor domain; Region: DeoRC; pfam00455 443906000976 Sugar kinases, ribokinase family [Carbohydrate transport and metabolism]; Region: RbsK; COG0524 443906000977 ribokinase/pfkB superfamily: Kinases that accept a wide variety of substrates, including carbohydrates and aromatic small molecules, all are phosphorylated at a hydroxyl group. The superfamily includes ribokinase, fructokinase, ketohexokinase; Region: ribokinase_pfkB_like; cl00192 443906000978 substrate binding site [chemical binding]; other site 443906000979 ATP binding site [chemical binding]; other site 443906000980 ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653 443906000981 ABC-type spermidine/putrescine transport system, permease component II [Amino acid transport and metabolism]; Region: PotC; COG1177 443906000982 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 443906000983 putative PBP binding loops; other site 443906000984 dimer interface [polypeptide binding]; other site 443906000985 ABC-ATPase subunit interface; other site 443906000986 ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395 443906000987 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 443906000988 dimer interface [polypeptide binding]; other site 443906000989 conserved gate region; other site 443906000990 putative PBP binding loops; other site 443906000991 ABC-ATPase subunit interface; other site 443906000992 GlcN6P_deaminase: Glucosamine-6-phosphate (GlcN6P) deaminase subfamily; GlcN6P deaminase catalyzes the reversible conversion of GlcN6P to D-fructose-6-phosphate (Fru6P) and ammonium. The reaction is an aldo-keto isomerization coupled with an amination or...; Region: GlcN6P_deaminase; cd01399 443906000993 active site 443906000994 trimer interface [polypeptide binding]; other site 443906000995 allosteric site; other site 443906000996 active site lid [active] 443906000997 hexamer (dimer of trimers) interface [polypeptide binding]; other site 443906000998 cryptic beta-D-galactosidase subunit alpha; Reviewed; Region: ebgA; PRK10340 443906000999 Glycosyl hydrolases family 2, sugar binding domain; Region: Glyco_hydro_2_N; pfam02837 443906001000 Glycosyl hydrolases family 2, TIM barrel domain; Region: Glyco_hydro_2_C; pfam02836 443906001001 Beta galactosidase small chain; Region: Bgal_small_N; smart01038 443906001002 4-hydroxybenzoyl-CoA thioesterase (4HBT). Catalyzes the final step in the 4-chlorobenzoate degradation pathway in which 4-chlorobenzoate is converted to 4-hydroxybenzoate in certain soil-dwelling bacteria. 4HBT forms a homotetramer with four active sites; Region: 4HBT; cd00586 443906001003 active site 443906001004 Predicted flavoprotein [General function prediction only]; Region: COG0431 443906001005 NADPH-dependent FMN reductase; Region: FMN_red; pfam03358 443906001006 Transcriptional regulators [Transcription]; Region: PurR; COG1609 443906001007 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 443906001008 DNA binding site [nucleotide binding] 443906001009 Ligand binding domain of the LacI tanscriptional regulator family belonging to the type I periplasmic-binding fold protein superfamily; Region: PBP1_LacI_sugar_binding_like; cd06267 443906001010 ligand binding site [chemical binding]; other site 443906001011 dimerization interface [polypeptide binding]; other site 443906001012 Bacterial extracellular solute-binding protein; Region: SBP_bac_8; pfam13416 443906001013 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; cl17199 443906001014 ABC-type spermidine/putrescine transport system, permease component II [Amino acid transport and metabolism]; Region: PotC; COG1177 443906001015 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 443906001016 dimer interface [polypeptide binding]; other site 443906001017 conserved gate region; other site 443906001018 putative PBP binding loops; other site 443906001019 ABC-ATPase subunit interface; other site 443906001020 ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395 443906001021 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 443906001022 dimer interface [polypeptide binding]; other site 443906001023 conserved gate region; other site 443906001024 putative PBP binding loops; other site 443906001025 ABC-ATPase subunit interface; other site 443906001026 putative alpha-glucosidase; Provisional; Region: PRK10658 443906001027 XylS is a glycosyl hydrolase family 31 (GH31) alpha-xylosidase found in prokaryotes, eukaryotes, and archaea, that catalyzes the release of alpha-xylose from the non-reducing terminal side of the alpha-xyloside substrate. XylS has been characterized in...; Region: GH31_xylosidase_XylS; cd06591 443906001028 putative active site [active] 443906001029 putative catalytic site [active] 443906001030 Helical backbone metal receptor (TroA-like domain). These proteins have been shown to function in the ABC transport of ferric siderophores and metal ions such as Mn2+, Fe3+, Cu2+ and/or Zn2+. Their ligand binding site is formed in the interface between...; Region: TroA-like; cl00262 443906001031 proposed F420-0 ABC transporter, periplasmic F420-0 binding protein; Region: F420-O_ABCperi; TIGR03868 443906001032 intersubunit interface [polypeptide binding]; other site 443906001033 iron-hydroxamate transporter permease subunit; Provisional; Region: PRK10577 443906001034 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550 443906001035 ABC-ATPase subunit interface; other site 443906001036 dimer interface [polypeptide binding]; other site 443906001037 putative PBP binding regions; other site 443906001038 ABC-type cobalamin/Fe3+-siderophores transport systems, ATPase components [Inorganic ion transport and metabolism / Coenzyme metabolism]; Region: FepC; COG1120 443906001039 ATP-binding component of iron-siderophores, vitamin B12 and hemin transporters and related proteins; Region: ABC_Iron-Siderophores_B12_Hemin; cd03214 443906001040 Walker A/P-loop; other site 443906001041 ATP binding site [chemical binding]; other site 443906001042 Q-loop/lid; other site 443906001043 ABC transporter signature motif; other site 443906001044 Walker B; other site 443906001045 D-loop; other site 443906001046 H-loop/switch region; other site 443906001047 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 443906001048 NAD dependent epimerase/dehydratase family; Region: Epimerase; pfam01370 443906001049 NAD(P) binding site [chemical binding]; other site 443906001050 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 443906001051 NAD(P) binding site [chemical binding]; other site 443906001052 active site 443906001053 active site 443906001054 ABC transporter, phosphonate, periplasmic substrate-binding protein; Region: Phosphonate-bd; pfam12974 443906001055 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 443906001056 substrate binding pocket [chemical binding]; other site 443906001057 membrane-bound complex binding site; other site 443906001058 phosphonate ABC transporter, ATP-binding protein; Region: ABC_phnC; TIGR02315 443906001059 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 443906001060 Walker A/P-loop; other site 443906001061 ATP binding site [chemical binding]; other site 443906001062 Q-loop/lid; other site 443906001063 ABC transporter signature motif; other site 443906001064 Walker B; other site 443906001065 D-loop; other site 443906001066 H-loop/switch region; other site 443906001067 phosphonate ABC transporter, permease protein PhnE; Region: PhnE; TIGR01097 443906001068 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 443906001069 dimer interface [polypeptide binding]; other site 443906001070 conserved gate region; other site 443906001071 putative PBP binding loops; other site 443906001072 ABC-ATPase subunit interface; other site 443906001073 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 443906001074 dimer interface [polypeptide binding]; other site 443906001075 conserved gate region; other site 443906001076 putative PBP binding loops; other site 443906001077 ABC-ATPase subunit interface; other site 443906001078 2-dehydropantoate 2-reductase; Provisional; Region: PRK12921 443906001079 Ketopantoate reductase PanE/ApbA; Region: ApbA; pfam02558 443906001080 Ketopantoate reductase PanE/ApbA C terminal; Region: ApbA_C; pfam08546 443906001081 phosphonate metabolim protein, transferase hexapeptide repeat family; Region: phn_thr-fam; TIGR03308 443906001082 Xenobiotic acyltransferase (XAT): The XAT class of hexapeptide acyltransferases is composed of a large number of microbial enzymes that catalyze the CoA-dependent acetylation of a variety of hydroxyl-bearing acceptors such as chloramphenicol and...; Region: LbH_XAT; cd03349 443906001083 trimer interface [polypeptide binding]; other site 443906001084 active site 443906001085 substrate binding site [chemical binding]; other site 443906001086 CoA binding site [chemical binding]; other site 443906001087 Nucleoside/nucleotide kinase (NK) is a protein superfamily consisting of multiple families of enzymes that share structural similarity and are functionally related to the catalysis of the reversible phosphate group transfer from nucleoside triphosphates...; Region: NK; cl17190 443906001088 phosphonate metabolism protein PhnM; Provisional; Region: PRK15446 443906001089 Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281 443906001090 active site 443906001091 Protein of unknown function (DUF1045); Region: DUF1045; cl15435 443906001092 phosphonate C-P lyase system protein PhnL; Region: CP_lyasePhnL; TIGR02324 443906001093 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 443906001094 Walker A/P-loop; other site 443906001095 ATP binding site [chemical binding]; other site 443906001096 Q-loop/lid; other site 443906001097 ABC transporter signature motif; other site 443906001098 Walker B; other site 443906001099 D-loop; other site 443906001100 phosphonate C-P lyase system protein PhnK; Provisional; Region: phnK; PRK11701 443906001101 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 443906001102 Walker A/P-loop; other site 443906001103 ATP binding site [chemical binding]; other site 443906001104 Q-loop/lid; other site 443906001105 ABC transporter signature motif; other site 443906001106 Walker B; other site 443906001107 D-loop; other site 443906001108 H-loop/switch region; other site 443906001109 Phosphonate metabolism protein PhnJ; Region: PhnJ; pfam06007 443906001110 Bacterial phosphonate metabolism protein (PhnI); Region: PhnI; pfam05861 443906001111 Bacterial phosphonate metabolism protein (PhnH); Region: PhnH; pfam05845 443906001112 Phosphonate metabolism protein PhnG; Region: PhnG; pfam06754 443906001113 phosphonates metabolism transcriptional regulator PhnF; Region: C_P_lyase_phnF; TIGR02325 443906001114 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 443906001115 DNA-binding site [nucleotide binding]; DNA binding site 443906001116 UTRA domain; Region: UTRA; pfam07702 443906001117 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 443906001118 Major Facilitator Superfamily; Region: MFS_1; pfam07690 443906001119 putative substrate translocation pore; other site 443906001120 Phosphoenolpyruvate carboxylase; Region: PEPcase; cl17418 443906001121 Phosphoenolpyruvate carboxylase [Energy production and conversion]; Region: Ppc; COG2352 443906001122 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 443906001123 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 443906001124 non-specific DNA binding site [nucleotide binding]; other site 443906001125 salt bridge; other site 443906001126 sequence-specific DNA binding site [nucleotide binding]; other site 443906001127 Threonine aldolase [Amino acid transport and metabolism]; Region: GLY1; COG2008 443906001128 Low-specificity threonine aldolase (TA). This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). TA catalyzes the conversion of L-threonine or L-allo-threonine to glycine and acetaldehyde in a...; Region: TA_like; cd06502 443906001129 tetramer interface [polypeptide binding]; other site 443906001130 pyridoxal 5'-phosphate binding site [chemical binding]; other site 443906001131 catalytic residue [active] 443906001132 GDP-mannose pyrophosphatase NudK; Provisional; Region: PRK15009 443906001133 ADP-ribose pyrophosphatase (ADPRase) catalyzes the hydrolysis of ADP-ribose and a variety of additional ADP-sugar conjugates to AMP and ribose-5-phosphate. Like other members of the Nudix hydrolase superfamily, it requires a divalent cation, such as Mg2+; Region: ADPRase_NUDT5; cd03424 443906001134 dimer interface [polypeptide binding]; other site 443906001135 ADP-ribose binding site [chemical binding]; other site 443906001136 active site 443906001137 nudix motif; other site 443906001138 metal binding site [ion binding]; metal-binding site 443906001139 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox_2; pfam07992 443906001140 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 443906001141 Asp23 family; Region: Asp23; pfam03780 443906001142 Major intrinsic protein (MIP) superfamily. Members of the MIP superfamily function as membrane channels that selectively transport water, small neutral molecules, and ions out of and between cells. The channel proteins share a common fold: the N-terminal...; Region: MIP; cl00200 443906001143 amphipathic channel; other site 443906001144 Asn-Pro-Ala signature motifs; other site 443906001145 Asp23 family; Region: Asp23; pfam03780 443906001146 Septum formation; Region: Septum_form; pfam13845 443906001147 Protein of unknown function (DUF805); Region: DUF805; pfam05656 443906001148 Predicted nucleotidyltransferase [General function prediction only]; Region: COG4849 443906001149 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4861 443906001150 Uncharacterized protein conserved in bacteria (DUF2186); Region: DUF2186; pfam09952 443906001151 ABC-type Na+ efflux pump, permease component [Energy production and conversion / Inorganic ion transport and metabolism]; Region: NatB; COG1668 443906001152 ABC-type uncharacterized transport system, ATPase component [General function prediction only]; Region: COG4152 443906001153 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 443906001154 Walker A/P-loop; other site 443906001155 ATP binding site [chemical binding]; other site 443906001156 Q-loop/lid; other site 443906001157 ABC transporter signature motif; other site 443906001158 Walker B; other site 443906001159 D-loop; other site 443906001160 H-loop/switch region; other site 443906001161 Domain of unknown function (DUF4162); Region: DUF4162; pfam13732 443906001162 SMP-30/Gluconolaconase/LRE-like region; Region: SGL; pfam08450 443906001163 3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05653 443906001164 classical (c) SDRs; Region: SDR_c; cd05233 443906001165 NAD(P) binding site [chemical binding]; other site 443906001166 active site 443906001167 classical (c) SDRs; Region: SDR_c; cd05233 443906001168 active site 443906001169 glycerol-3-phosphate transporter; Region: glpT; TIGR00712 443906001170 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 443906001171 putative substrate translocation pore; other site 443906001172 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 443906001173 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 443906001174 active site 443906001175 phosphorylation site [posttranslational modification] 443906001176 intermolecular recognition site; other site 443906001177 dimerization interface [polypeptide binding]; other site 443906001178 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 443906001179 DNA binding residues [nucleotide binding] 443906001180 dimerization interface [polypeptide binding]; other site 443906001181 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: COG4585 443906001182 Histidine kinase; Region: HisKA_3; pfam07730 443906001183 Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase; Region: HATPase_c; pfam02518 443906001184 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 443906001185 putative substrate translocation pore; other site 443906001186 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 443906001187 alpha/beta hydrolase fold; Region: Abhydrolase_1; pfam00561 443906001188 TAP-like protein; Region: Abhydrolase_4; pfam08386 443906001189 short chain dehydrogenase; Validated; Region: PRK08264 443906001190 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 443906001191 NAD(P) binding site [chemical binding]; other site 443906001192 active site 443906001193 Helix-Turn-Helix DNA binding domain of transcription regulators from the MerR superfamily; Region: HTH_MerR-SF; cl02600 443906001194 MerR HTH family regulatory protein; Region: MerR_1; pfam13411 443906001195 DNA binding residues [nucleotide binding] 443906001196 Transcriptional regulators [Transcription]; Region: MarR; COG1846 443906001197 MarR family; Region: MarR; pfam01047 443906001198 peroxiredoxin, Ohr subfamily; Region: organ_hyd_perox; TIGR03561 443906001199 Predicted membrane protein [Function unknown]; Region: COG4270 443906001200 This conserved domain belongs to a superfamily including the bleomycin resistance protein, glyoxalase I, and type I ring-cleaving dioxygenases; Region: Glo_EDI_BRP_like_24; cd09012 443906001201 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 443906001202 Epoxide hydrolase N terminus; Region: EHN; pfam06441 443906001203 Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596 443906001204 AAA ATPase domain; Region: AAA_16; pfam13191 443906001205 AAA domain; Region: AAA_22; pfam13401 443906001206 Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653 443906001207 Transmembrane subunit (TM) of Escherichia coli AraH and related proteins. E. coli AraH is the TM of a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of the monosaccharide arabinose. This group...; Region: TM_PBP1_transp_AraH_like; cd06579 443906001208 TM-ABC transporter signature motif; other site 443906001209 Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653 443906001210 Transmembrane subunit (TM) of Escherichia coli AraH and related proteins. E. coli AraH is the TM of a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of the monosaccharide arabinose. This group...; Region: TM_PBP1_transp_AraH_like; cd06579 443906001211 TM-ABC transporter signature motif; other site 443906001212 ABC-type sugar transport system, ATPase component [Carbohydrate transport and metabolism]; Region: MglA; COG1129 443906001213 First domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_I; cd03216 443906001214 Walker A/P-loop; other site 443906001215 ATP binding site [chemical binding]; other site 443906001216 Q-loop/lid; other site 443906001217 ABC transporter signature motif; other site 443906001218 Walker B; other site 443906001219 D-loop; other site 443906001220 H-loop/switch region; other site 443906001221 Second domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_II; cd03215 443906001222 Periplasmic binding domain of ABC-type YtfQ-like transport systems; Region: PBP1_YtfQ_like; cd06309 443906001223 Periplasmic binding protein domain; Region: Peripla_BP_4; pfam13407 443906001224 putative ligand binding site [chemical binding]; other site 443906001225 ABC-type sugar transport system, ATPase component [Carbohydrate transport and metabolism]; Region: MglA; COG1129 443906001226 First domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_I; cd03216 443906001227 Walker A/P-loop; other site 443906001228 ATP binding site [chemical binding]; other site 443906001229 Q-loop/lid; other site 443906001230 ABC transporter signature motif; other site 443906001231 Walker B; other site 443906001232 D-loop; other site 443906001233 H-loop/switch region; other site 443906001234 Second domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_II; cd03215 443906001235 Transcriptional regulators [Transcription]; Region: PurR; COG1609 443906001236 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 443906001237 DNA binding site [nucleotide binding] 443906001238 domain linker motif; other site 443906001239 Ligand-binding domain of DNA transcription repressor LacI specific for lactose, a member of the LacI-GalR family of bacterial transcription regulators; Region: PBP1_LacI; cd01574 443906001240 ligand binding site [chemical binding]; other site 443906001241 dimerization interface (open form) [polypeptide binding]; other site 443906001242 dimerization interface (closed form) [polypeptide binding]; other site 443906001243 Manganese catalase, ferritin-like diiron-binding domain; Region: Mn_catalase; cd01051 443906001244 dimanganese center [ion binding]; other site 443906001245 Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118 443906001246 putative phosphoketolase; Provisional; Region: PRK05261 443906001247 Thiamine pyrophosphate (TPP) family, Phosphoketolase (PK) subfamily, TPP-binding module; PK catalyzes the conversion of D-xylulose 5-phosphate and phosphate to acetyl phosphate, D-glyceraldehyde-3-phosphate and H2O. This enzyme requires divalent...; Region: TPP_PK; cd02011 443906001248 TPP-binding site; other site 443906001249 XFP C-terminal domain; Region: XFP_C; pfam09363 443906001250 Carboxypeptidase regulatory-like domain; Region: CarboxypepD_reg; pfam13620 443906001251 Carboxypeptidase regulatory-like domain; Region: CarboxypepD_reg; pfam13620 443906001252 Carboxypeptidase regulatory-like domain; Region: CarboxypepD_reg; pfam13620 443906001253 Pentapeptide repeats containing protein [Function unknown]; Region: COG1357 443906001254 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550 443906001255 ABC-ATPase subunit interface; other site 443906001256 dimer interface [polypeptide binding]; other site 443906001257 putative PBP binding regions; other site 443906001258 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cl00462 443906001259 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550 443906001260 dimer interface [polypeptide binding]; other site 443906001261 putative PBP binding regions; other site 443906001262 iron-hydroxamate transporter permease subunit; Provisional; Region: PRK10577 443906001263 ABC-ATPase subunit interface; other site 443906001264 ABC-type Fe3+-hydroxamate transport system, periplasmic component [Inorganic ion transport and metabolism]; Region: FepB; COG0614 443906001265 Helical backbone metal receptor (TroA-like domain). These proteins have been shown to function in the ABC transport of ferric siderophores and metal ions such as Mn2+, Fe3+, Cu2+ and/or Zn2+. Their ligand binding site is formed in the interface between...; Region: TroA-like; cl00262 443906001266 intersubunit interface [polypeptide binding]; other site 443906001267 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl17182 443906001268 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 443906001269 S-adenosylmethionine binding site [chemical binding]; other site 443906001270 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 443906001271 Phenolic acid decarboxylase (PAD); Region: PA_decarbox; cl01382 443906001272 helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347 443906001273 MarR family; Region: MarR_2; pfam12802 443906001274 Transcriptional regulators [Transcription]; Region: MarR; COG1846 443906001275 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 443906001276 putative DNA binding site [nucleotide binding]; other site 443906001277 putative Zn2+ binding site [ion binding]; other site 443906001278 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 443906001279 Major Facilitator Superfamily; Region: MFS_1; pfam07690 443906001280 putative substrate translocation pore; other site 443906001281 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 443906001282 This domain superfamily is found in a variety of structurally related metalloproteins, including the type I extradiol dioxygenases, glyoxalase I and a group of antibiotic resistance proteins; Region: Glo_EDI_BRP_like; cd06587 443906001283 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 443906001284 active site 443906001285 Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281 443906001286 Imidazolonepropionase and related amidohydrolases [Secondary metabolites biosynthesis, transport, and catabolism]; Region: HutI; COG1228 443906001287 Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281 443906001288 active site 443906001289 Domain of unknown function (DUF1905); Region: DUF1905; pfam08922 443906001290 Nucleoside/nucleotide kinase (NK) is a protein superfamily consisting of multiple families of enzymes that share structural similarity and are functionally related to the catalysis of the reversible phosphate group transfer from nucleoside triphosphates...; Region: NK; cl17190 443906001291 Catalytic domain of phospholipase D superfamily proteins; Region: PLDc_SF; cl15239 443906001292 Dehydrogenases with different specificities (related to short-chain alcohol dehydrogenases) [Secondary metabolites biosynthesis, transport, and catabolism / General function prediction only]; Region: FabG; COG1028 443906001293 classical (c) SDRs; Region: SDR_c; cd05233 443906001294 active site 443906001295 Acetyltransferase (GNAT) domain; Region: Acetyltransf_3; pfam13302 443906001296 Acetyltransferase (GNAT) family; Region: Acetyltransf_1; pfam00583 443906001297 Phosphate/sulphate permeases [Inorganic ion transport and metabolism]; Region: PitA; COG0306 443906001298 Protein of unknown function (DUF3349); Region: DUF3349; pfam11829 443906001299 Protein of unknown function (DUF3349); Region: DUF3349; pfam11829 443906001300 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 443906001301 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 443906001302 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 443906001303 putative substrate translocation pore; other site 443906001304 Putative hydrophobic ligand-binding SRPBCC domain of Micromonospora echinospora CalC, human Aha1, and related proteins; Region: SRPBCC_CalC_Aha1-like; cd07814 443906001305 putative hydrophobic ligand binding site [chemical binding]; other site 443906001306 Histidine phosphatase domain found in a functionally diverse set of proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP; cl11399 443906001307 Histidine phosphatase domain found in histidine acid phosphatases and phytases; contains a His residue which is phosphorylated during the reaction; Region: HP_HAP_like; cd07061 443906001308 Predicted permeases [General function prediction only]; Region: COG0679 443906001309 Acetyltransferase (GNAT) family; Region: Acetyltransf_1; pfam00583 443906001310 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 443906001311 NAD(P) binding site [chemical binding]; other site 443906001312 active site 443906001313 TM1410 hypothetical-related protein; Region: DUF297; cl00997 443906001314 ASC-1 homology domain, subfamily similar to Enterococcus faecalis Ef3133. The ASCH domain, a small beta-barrel domain found in all three kingdoms of life, resembles the RNA-binding PUA domain and may also interact with RNA. ASCH has been proposed to...; Region: ASCH_Ef3133_like; cd06553 443906001315 oxidoreductase; Provisional; Region: PRK06128 443906001316 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 443906001317 NAD(P) binding site [chemical binding]; other site 443906001318 active site 443906001319 MOSC domain; Region: MOSC; pfam03473 443906001320 phosphate regulon sensor kinase PhoR; Region: phoR_proteo; TIGR02966 443906001321 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 443906001322 putative active site [active] 443906001323 heme pocket [chemical binding]; other site 443906001324 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 443906001325 dimer interface [polypeptide binding]; other site 443906001326 phosphorylation site [posttranslational modification] 443906001327 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 443906001328 ATP binding site [chemical binding]; other site 443906001329 Mg2+ binding site [ion binding]; other site 443906001330 G-X-G motif; other site 443906001331 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 443906001332 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 443906001333 active site 443906001334 phosphorylation site [posttranslational modification] 443906001335 intermolecular recognition site; other site 443906001336 dimerization interface [polypeptide binding]; other site 443906001337 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 443906001338 DNA binding site [nucleotide binding] 443906001339 Escherichia coli exonuclease III (ExoIII) and Neisseria meningitides NExo-like subfamily of the ExoIII family purinic/apyrimidinic (AP) endonucleases; Region: ExoIII-like_AP-endo; cd09086 443906001340 putative catalytic site [active] 443906001341 putative phosphate binding site [ion binding]; other site 443906001342 active site 443906001343 metal binding site A [ion binding]; metal-binding site 443906001344 DNA binding site [nucleotide binding] 443906001345 putative AP binding site [nucleotide binding]; other site 443906001346 putative metal binding site B [ion binding]; other site 443906001347 Asp23 family; Region: Asp23; pfam03780 443906001348 RNA polymerase sigma factor, sigma-70 family; Region: sigma70-ECF; TIGR02937 443906001349 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 443906001350 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 443906001351 DNA binding residues [nucleotide binding] 443906001352 Asp23 family; Region: Asp23; pfam03780 443906001353 3-hydroxyisobutyrate dehydrogenase and related beta-hydroxyacid dehydrogenases [Lipid metabolism]; Region: MmsB; COG2084 443906001354 6-phosphogluconate dehydrogenase-like protein; Reviewed; Region: PRK09599 443906001355 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 443906001356 active site 443906001357 Septum formation; Region: Septum_form; pfam13845 443906001358 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 443906001359 UMP phosphatase; Provisional; Region: PRK10444 443906001360 active site 443906001361 motif I; other site 443906001362 motif II; other site 443906001363 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 443906001364 Enterobacter aerogenes GpdQ and related proteins, metallophosphatase domain; Region: MPP_GpdQ; cd07402 443906001365 Calcineurin-like phosphoesterase; Region: Metallophos; pfam00149 443906001366 active site 443906001367 metal binding site [ion binding]; metal-binding site 443906001368 hexamer interface [polypeptide binding]; other site 443906001369 CsbD-like; Region: CsbD; cl17424 443906001370 Phospholipase_D-nuclease N-terminal; Region: PLDc_N; pfam13396 443906001371 Superfamily II DNA helicase [DNA replication, recombination, and repair]; Region: RecQ; COG0514 443906001372 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 443906001373 ATP binding site [chemical binding]; other site 443906001374 putative Mg++ binding site [ion binding]; other site 443906001375 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 443906001376 nucleotide binding region [chemical binding]; other site 443906001377 ATP-binding site [chemical binding]; other site 443906001378 DNA methylase; Region: N6_N4_Mtase; cl17433 443906001379 DNA modification methylase [DNA replication, recombination, and repair]; Region: COG0863 443906001380 DNA methylase; Region: N6_N4_Mtase; pfam01555 443906001381 Domain of unknown function (DUF4190); Region: DUF4190; pfam13828 443906001382 Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321 443906001383 kynureninase; Region: kynureninase; TIGR01814 443906001384 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 443906001385 catalytic residue [active] 443906001386 Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408 443906001387 Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013 443906001388 Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013 443906001389 Glycosyl transferases, related to UDP-glucuronosyltransferase [Carbohydrate transport and metabolism / Signal transduction mechanisms]; Region: COG1819 443906001390 Uncharacterized conserved protein [Function unknown]; Region: COG2308 443906001391 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2307 443906001392 A predicted alpha-helical domain with a conserved ER motif; Region: Alpha-E; pfam04168 443906001393 Transglutaminase-like enzymes, putative cysteine proteases [Amino acid transport and metabolism]; Region: COG1305 443906001394 Bacterial transglutaminase-like N-terminal region; Region: Bact_transglu_N; pfam08379 443906001395 Transglutaminase-like superfamily; Region: Transglut_core; pfam01841 443906001396 Lysophospholipase [Lipid metabolism]; Region: PldB; COG2267 443906001397 Putative lysophospholipase; Region: Hydrolase_4; pfam12146 443906001398 Pro-kumamolisin, activation domain; Region: Pro-kuma_activ; smart00944 443906001399 Peptidase domain in the S53 family; Region: Peptidases_S53; cd04056 443906001400 active site 443906001401 catalytic triad [active] 443906001402 calcium binding site [ion binding]; other site 443906001403 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 443906001404 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 443906001405 phospholipase C, phosphocholine-specific, Pseudomonas-type; Region: PC_PLC; TIGR03396 443906001406 Phosphoesterase family; Region: Phosphoesterase; pfam04185 443906001407 Domain of unknown function (DUF756); Region: DUF756; pfam05506 443906001408 Domain of unknown function (DUF756); Region: DUF756; pfam05506 443906001409 Alkylated DNA repair protein [DNA replication, recombination, and repair]; Region: AlkB; COG3145 443906001410 Lipoate-protein ligase A [Coenzyme metabolism]; Region: LplA; COG0095 443906001411 Predicted acetyltransferase [General function prediction only]; Region: COG2388 443906001412 Immunoglobulin-like fold, Plexins, Transcription factors (IPT). IPTs are also known as Transcription factor ImmunoGlobin (TIG) domains. They are present in intracellular transcription factors, cell surface receptors (such as plexins and scatter factor...; Region: IPT; cd00102 443906001413 Putative amidase domain; Region: Amidase_6; pfam12671 443906001414 Protein of unknown function (DUF2809); Region: DUF2809; pfam10990 443906001415 phosphoglucomutase; Validated; Region: PRK07564 443906001416 The alpha-D-phosphohexomutase superfamily includes several related enzymes that catalyze a reversible intramolecular phosphoryl transfer on their sugar substrates. Members of this family include the phosphoglucomutases (PGM1 and PGM2), phosphoglucosamine...; Region: phosphohexomutase; cl03757 443906001417 active site 443906001418 substrate binding site [chemical binding]; other site 443906001419 metal binding site [ion binding]; metal-binding site 443906001420 Prephenate dehydratase; Region: PDT; pfam00800 443906001421 prephenate dehydratase; Provisional; Region: PRK11898 443906001422 C-terminal ACT domain of the bifunctional chorismate mutase-prephenate dehydratase (CM-PDT) enzyme and the prephenate dehydratase (PDT) enzyme; Region: ACT_CM-PDT; cd04905 443906001423 putative L-Phe binding site [chemical binding]; other site 443906001424 seryl-tRNA synthetase; Provisional; Region: PRK05431 443906001425 Seryl-tRNA synthetase N-terminal domain; Region: Seryl_tRNA_N; pfam02403 443906001426 Seryl-tRNA synthetase (SerRS) class II core catalytic domain. SerRS is responsible for the attachment of serine to the 3' OH group of ribose of the appropriate tRNA. This domain It is primarily responsible for ATP-dependent formation of the enzyme...; Region: SerRS_core; cd00770 443906001427 dimer interface [polypeptide binding]; other site 443906001428 active site 443906001429 motif 1; other site 443906001430 motif 2; other site 443906001431 motif 3; other site 443906001432 haloacid dehalogenase-like hydrolase; Region: Hydrolase_3; pfam08282 443906001433 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 443906001434 Cell envelope-related transcriptional attenuator domain; Region: LytR_cpsA_psr; cl00581 443906001435 Transcriptional regulators [Transcription]; Region: PurR; COG1609 443906001436 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 443906001437 DNA binding site [nucleotide binding] 443906001438 domain linker motif; other site 443906001439 Ligand-binding domain of a LacI-like transcriptional regulator, CatR which is involved in catechol degradation; Region: PBP1_CatR_like; cd06296 443906001440 putative dimerization interface [polypeptide binding]; other site 443906001441 putative ligand binding site [chemical binding]; other site 443906001442 Type 1 glutamine amidotransferase (GATase1)-like domain; Region: GAT_1; cl00020 443906001443 Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673 443906001444 Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408 443906001445 Alpha amylase catalytic domain found in bacterial cyclomaltodextrinases and related proteins; Region: AmyAc_bac_CMD_like; cd11354 443906001446 Glycosidases [Carbohydrate transport and metabolism]; Region: AmyA; COG0366 443906001447 active site 443906001448 catalytic site [active] 443906001449 Predicted transcriptional regulators [Transcription]; Region: COG1695 443906001450 Transcriptional regulator PadR-like family; Region: PadR; pfam03551 443906001451 membrane protein insertase, YidC/Oxa1 family, C-terminal domain; Region: yidC_oxa1_cterm; TIGR03592 443906001452 Predicted metal-dependent hydrolases related to alanyl-tRNA synthetase HxxxH domain [General function prediction only]; Region: COG2872 443906001453 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 443906001454 Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248 443906001455 active site 443906001456 catalytic tetrad [active] 443906001457 1-acyl-sn-glycerol-3-phosphate acyltransferase [Lipid metabolism]; Region: PlsC; COG0204 443906001458 Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: AGPAT-like; Region: LPLAT_AGPAT-like; cd07989 443906001459 putative acyl-acceptor binding pocket; other site 443906001460 Aspartate alpha-decarboxylase or L-aspartate 1-decarboxylase, a pyruvoyl group-dependent decarboxylase in beta-alanine production; Region: Asp_decarbox; cd06919 443906001461 tetramerization interface [polypeptide binding]; other site 443906001462 active site 443906001463 Virulence factor BrkB; Region: Virul_fac_BrkB; pfam03631 443906001464 Deoxyribodipyrimidine photolyase [DNA replication, recombination, and repair]; Region: PhrB; COG0415 443906001465 DNA photolyase; Region: DNA_photolyase; pfam00875 443906001466 Glycosyltransferases, probably involved in cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: COG1215 443906001467 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cd00761 443906001468 active site 443906001469 Transcriptional regulators [Transcription]; Region: MarR; COG1846 443906001470 Winged helix DNA-binding domain; Region: HTH_27; pfam13463 443906001471 MarR family; Region: MarR_2; cl17246 443906001472 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 443906001473 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 443906001474 DNA binding site [nucleotide binding] 443906001475 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 443906001476 active site 443906001477 Nucleoside deaminases include adenosine, guanine and cytosine deaminases. These enzymes are Zn dependent and catalyze the deamination of nucleosides. The zinc ion in the active site plays a central role in the proposed catalytic mechanism, activating a...; Region: nucleoside_deaminase; cd01285 443906001478 nucleoside/Zn binding site; other site 443906001479 dimer interface [polypeptide binding]; other site 443906001480 catalytic motif [active] 443906001481 CGNR zinc finger; Region: zf-CGNR; pfam11706 443906001482 Carboxymuconolactone decarboxylase family; Region: CMD; cl00460 443906001483 Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281 443906001484 active site 443906001485 Predicted Co/Zn/Cd cation transporters [Inorganic ion transport and metabolism]; Region: MMT1; COG0053 443906001486 Cation efflux family; Region: Cation_efflux; pfam01545 443906001487 NADP oxidoreductase coenzyme F420-dependent; Region: F420_oxidored; cl17232 443906001488 pyrroline-5-carboxylate reductase; Reviewed; Region: PRK11880 443906001489 K+ transport systems, NAD-binding component [Inorganic ion transport and metabolism]; Region: TrkA; COG0569 443906001490 TrkA-N domain; Region: TrkA_N; pfam02254 443906001491 TrkA-C domain; Region: TrkA_C; pfam02080 443906001492 Cation transport protein; Region: TrkH; cl17365 443906001493 potassium uptake protein, TrkH family; Region: 2a38; TIGR00933 443906001494 Trk-type K+ transport systems, membrane components [Inorganic ion transport and metabolism]; Region: TrkG; COG0168 443906001495 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 443906001496 putative DNA binding site [nucleotide binding]; other site 443906001497 putative Zn2+ binding site [ion binding]; other site 443906001498 DNA binding domain, excisionase family; Region: excise; TIGR01764 443906001499 Phosphoserine phosphatase [Amino acid transport and metabolism]; Region: SerB; COG0560 443906001500 haloacid dehalogenase-like hydrolase; Region: HAD; cl17202 443906001501 Glutaredoxin-like domain (DUF836); Region: DUF836; pfam05768 443906001502 Stress responsive A/B Barrel Domain; Region: Dabb; smart00886 443906001503 Transcriptional regulators [Transcription]; Region: PurR; COG1609 443906001504 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 443906001505 DNA binding site [nucleotide binding] 443906001506 domain linker motif; other site 443906001507 Ligand-binding domain of DNA-binding regulatory proteins specific to sucrose that are members of the LacI-GalR family of bacterial transcription repressors; Region: PBP1_sucrose_transcription_regulator; cd06288 443906001508 putative dimerization interface [polypeptide binding]; other site 443906001509 putative ligand binding site [chemical binding]; other site 443906001510 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 443906001511 Major Facilitator Superfamily; Region: MFS_1; pfam07690 443906001512 putative substrate translocation pore; other site 443906001513 Putative lysophospholipase; Region: Hydrolase_4; pfam12146 443906001514 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 443906001515 SGNH_hydrolase, or GDSL_hydrolase, is a diverse family of lipases and esterases. The tertiary fold of the enzyme is substantially different from that of the alpha/beta hydrolase family and unique among all known hydrolases; its active site closely...; Region: SGNH_hydrolase; cl01053 443906001516 active site 443906001517 catalytic triad [active] 443906001518 oxyanion hole [active] 443906001519 Uncharacterized protein involved in exopolysaccharide biosynthesis [Cell envelope biogenesis, outer membrane]; Region: GumC; COG3206 443906001520 Cell envelope-related transcriptional attenuator domain; Region: LytR_cpsA_psr; cl00581 443906001521 aspartyl-tRNA synthetase; Provisional; Region: aspC; PRK05159 443906001522 Asp_Lys_Asn_RS_N: N-terminal, anticodon recognition domain of class 2b aminoacyl-tRNA synthetases (aaRSs). This domain is a beta-barrel domain (OB fold) involved in binding the tRNA anticodon stem-loop. Class 2b aaRSs include the homodimeric aspartyl-; Region: Asp_Lys_Asn_RS_N; cd04100 443906001523 Dimer interface [polypeptide binding]; other site 443906001524 anticodon binding site; other site 443906001525 Class II tRNA amino-acyl synthetase-like catalytic core domain. Class II amino acyl-tRNA synthetases (aaRS) share a common fold and generally attach an amino acid to the 3' OH of ribose of the appropriate tRNA. PheRS is an exception in that it...; Region: class_II_aaRS-like_core; cl00268 443906001526 motif 1; other site 443906001527 dimer interface [polypeptide binding]; other site 443906001528 active site 443906001529 motif 2; other site 443906001530 motif 3; other site 443906001531 LamB/YcsF family of lactam utilization protein; Region: LamB_YcsF_like; cd10787 443906001532 putative active site [active] 443906001533 Allophanate hydrolase subunit 1; Region: AHS1; pfam02682 443906001534 Allophanate hydrolase subunit 1 [Amino acid transport and metabolism]; Region: DUR1; cl00896 443906001535 Allophanate hydrolase subunit 2 [Amino acid transport and metabolism]; Region: DUR1; COG1984 443906001536 Protein of unknown function (DUF2510); Region: DUF2510; pfam10708 443906001537 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 443906001538 Walker A/P-loop; other site 443906001539 ATP binding site [chemical binding]; other site 443906001540 Excinuclease ATPase subunit [DNA replication, recombination, and repair]; Region: UvrA; COG0178 443906001541 Q-loop/lid; other site 443906001542 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 443906001543 ABC transporter signature motif; other site 443906001544 Walker B; other site 443906001545 D-loop; other site 443906001546 H-loop/switch region; other site 443906001547 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 443906001548 Walker A/P-loop; other site 443906001549 ATP binding site [chemical binding]; other site 443906001550 Q-loop/lid; other site 443906001551 ABC transporter signature motif; other site 443906001552 Walker B; other site 443906001553 D-loop; other site 443906001554 H-loop/switch region; other site 443906001555 RNA polymerase sigma factor SigB; Reviewed; Region: PRK07921 443906001556 Sigma-70 factor, region 1.2; Region: Sigma70_r1_2; pfam00140 443906001557 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 443906001558 Sigma-70 region 3; Region: Sigma70_r3; pfam04539 443906001559 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 443906001560 DNA binding residues [nucleotide binding] 443906001561 Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067 443906001562 catalytic core [active] 443906001563 TlpA-like family; composed of TlpA, ResA, DsbE and similar proteins. TlpA, ResA and DsbE are bacterial protein disulfide reductases with important roles in cytochrome maturation. They are membrane-anchored proteins with a soluble TRX domain containing a...; Region: TlpA_like_family; cd02966 443906001564 Thioredoxin-like; Region: Thioredoxin_8; pfam13905 443906001565 catalytic residues [active] 443906001566 Cytochrome c biogenesis protein [Posttranslational modification, protein turnover, chaperones]; Region: CcdA; COG0785 443906001567 Cytochrome C biogenesis protein transmembrane region; Region: DsbD; cl15788 443906001568 ResB-like family; Region: ResB; pfam05140 443906001569 ResB protein required for cytochrome c biosynthesis [Posttranslational modification, protein turnover, chaperones]; Region: ResB; cl09125 443906001570 cytochrome c-type biogenesis protein CcsB; Region: cytochr_II_ccsB; TIGR03144 443906001571 O-succinylbenzoate synthase; Provisional; Region: PRK02901 443906001572 o-Succinylbenzoate synthase (OSBS) catalyzes the conversion of 2-succinyl-6-hydroxy-2,4-cyclohexadiene-1-carboxylate (SHCHC) to 4-(2'-carboxyphenyl)-4-oxobutyrate (o-succinylbenzoate or OSB), a reaction in the menaquinone biosynthetic pathway; Region: OSBS; cd03320 443906001573 active site 443906001574 Site-specific DNA methylase [DNA replication, recombination, and repair]; Region: Dcm; COG0270 443906001575 Cytosine-C5 specific DNA methylases; Methyl transfer reactions play an important role in many aspects of biology. Cytosine-specific DNA methylases are found both in prokaryotes and eukaryotes. DNA methylation, or the covalent addition of a methyl group...; Region: Cyt_C5_DNA_methylase; cd00315 443906001576 cofactor binding site; other site 443906001577 DNA binding site [nucleotide binding] 443906001578 substrate interaction site [chemical binding]; other site 443906001579 Cytosine-C5 specific DNA methylases; Methyl transfer reactions play an important role in many aspects of biology. Cytosine-specific DNA methylases are found both in prokaryotes and eukaryotes. DNA methylation, or the covalent addition of a methyl group...; Region: Cyt_C5_DNA_methylase; cd00315 443906001580 GIY-YIG nuclease domain superfamily; Region: GIY-YIG_SF; cd00719 443906001581 GIY-YIG motif/motif A; other site 443906001582 active site 443906001583 catalytic site [active] 443906001584 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 443906001585 Enoyl-CoA hydratase/isomerase family; Region: ECH; pfam00378 443906001586 substrate binding site [chemical binding]; other site 443906001587 oxyanion hole (OAH) forming residues; other site 443906001588 trimer interface [polypeptide binding]; other site 443906001589 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 443906001590 acyl-activating enzyme (AAE) consensus motif; other site 443906001591 active site 443906001592 AMP binding site [chemical binding]; other site 443906001593 CoA binding site [chemical binding]; other site 443906001594 Quinone oxidoreductase (QOR); Region: quinone_oxidoreductase_like_1; cd08243 443906001595 NADPH:quinone reductase and related Zn-dependent oxidoreductases [Energy production and conversion / General function prediction only]; Region: Qor; COG0604 443906001596 putative NAD(P) binding site [chemical binding]; other site 443906001597 SnoaL-like polyketide cyclase; Region: SnoaL; pfam07366 443906001598 Members of the Nudix hydrolase superfamily catalyze the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+, for their activity and contain a highly...; Region: Nudix_Hydrolase_31; cd04690 443906001599 nudix motif; other site 443906001600 Acetyltransferases, including N-acetylases of ribosomal proteins [Translation, ribosomal structure and biogenesis]; Region: RimL; COG1670 443906001601 Acetyltransferase (GNAT) family; Region: Acetyltransf_1; pfam00583 443906001602 Acetyltransferases, including N-acetylases of ribosomal proteins [Translation, ribosomal structure and biogenesis]; Region: RimL; COG1670 443906001603 Acetyltransferase (GNAT) family; Region: Acetyltransf_1; pfam00583 443906001604 glutamyl-tRNA reductase; Reviewed; Region: hemA; PRK00045 443906001605 NAD(P) binding domain of amino acid dehydrogenase-like proteins; Region: NAD_bind_amino_acid_DH; cl17226 443906001606 NAD(P) binding pocket [chemical binding]; other site 443906001607 Glutamyl-tRNAGlu reductase, dimerisation domain; Region: GlutR_dimer; pfam00745 443906001608 Uroporphyrinogen decarboxylase (URO-D) is a dimeric cytosolic enzyme that decarboxylates the four acetate side chains of uroporphyrinogen III (uro-III) to create coproporphyrinogen III, without requiring any prosthetic groups or cofactors. This reaction...; Region: URO-D; cd00717 443906001609 substrate binding site [chemical binding]; other site 443906001610 active site 443906001611 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450 443906001612 protoporphyrinogen oxidase; Reviewed; Region: PRK11883 443906001613 Protein of unknown function (DUF1469); Region: DUF1469; pfam07332 443906001614 Protein of unknown function (DUF3618); Region: DUF3618; pfam12277 443906001615 carotene biosynthesis associated membrane protein; Region: crt_membr; TIGR03459 443906001616 uncharacterized Actinobacterial protein TIGR03083; Region: TIGR03083 443906001617 TIGR03086 family protein; Region: TIGR03086 443906001618 Chlorite dismutase; Region: Chlor_dismutase; pfam06778 443906001619 ferrochelatase; Reviewed; Region: hemH; PRK00035 443906001620 Ferrochelatase, N-terminal domain: Ferrochelatase (protoheme ferrolyase or HemH) is the terminal enzyme of the heme biosynthetic pathway. It catalyzes the insertion of ferrous iron into the protoporphyrin IX ring yielding protoheme. This enzyme is...; Region: Ferrochelatase_N; cd03411 443906001621 C-terminal domain interface [polypeptide binding]; other site 443906001622 active site 443906001623 Ferrochelatase, C-terminal domain: Ferrochelatase (protoheme ferrolyase or HemH) is the terminal enzyme of the heme biosynthetic pathway. It catalyzes the insertion of ferrous iron into the protoporphyrin IX ring yielding protoheme. This enzyme is...; Region: Ferrochelatase_C; cd00419 443906001624 active site 443906001625 N-terminal domain interface [polypeptide binding]; other site 443906001626 porphobilinogen deaminase; Reviewed; Region: hemC; PRK00072 443906001627 Hydroxymethylbilane synthase (HMBS), also known as porphobilinogen deaminase (PBGD), is an intermediate enzyme in the biosynthetic pathway of tetrapyrrolic ring systems, such as heme, chlorophylls, and vitamin B12. HMBS catalyzes the conversion of...; Region: HMBS; cl17708 443906001628 domain interfaces; other site 443906001629 active site 443906001630 Uroporphyrinogen-III synthase [Coenzyme metabolism]; Region: HemD; COG1587 443906001631 Uroporphyrinogen-III synthase (HemD) catalyzes the asymmetrical cyclization of tetrapyrrole (linear) to uroporphyrinogen-III, the fourth step in the biosynthesis of heme. This ubiquitous enzyme is present in eukaryotes, bacteria and archaea. Mutations in...; Region: HemD; cd06578 443906001632 active site 443906001633 Porphobilinogen synthase (PBGS), which is also called delta-aminolevulinic acid dehydratase (ALAD), catalyzes the condensation of two 5-aminolevulinic acid (ALA) molecules to form the pyrrole porphobilinogen (PBG), which is the second step in the...; Region: ALAD_PBGS; cd00384 443906001634 dimer interface [polypeptide binding]; other site 443906001635 active site 443906001636 Schiff base residues; other site 443906001637 glutamate-1-semialdehyde aminotransferase; Provisional; Region: PRK00062 443906001638 Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610 443906001639 inhibitor-cofactor binding pocket; inhibition site 443906001640 pyridoxal 5'-phosphate binding site [chemical binding]; other site 443906001641 catalytic residue [active] 443906001642 DNA/RNA non-specific endonuclease; prokaryotic and eukaryotic double- and single-stranded DNA and RNA endonucleases also present in phosphodiesterases. They exists as monomers and homodimers; Region: NUC; cd00091 443906001643 DNA/RNA non-specific endonuclease; Region: Endonuclease_NS; smart00892 443906001644 active site 443906001645 substrate binding site [chemical binding]; other site 443906001646 Mg2+ binding site [ion binding]; other site 443906001647 Heme oxygenase catalyzes the rate limiting step in the degradation of heme to bilirubin, it is essential for recycling of iron from heme. Heme is used as a substrate and cofactor for its own degradation to biliverdin, iron, and carbon monoxide. This...; Region: HemeO; cd00232 443906001648 heme binding pocket [chemical binding]; other site 443906001649 heme ligand [chemical binding]; other site 443906001650 Protein of unknown function (DUF1304); Region: DUF1304; pfam06993 443906001651 Yhdh putative quinone oxidoreductases; Region: MDR_yhdh; cd08288 443906001652 putative quinone oxidoreductase, YhdH/YhfP family; Region: oxido_YhdH; TIGR02823 443906001653 NADP binding site [chemical binding]; other site 443906001654 dimer interface [polypeptide binding]; other site 443906001655 6-phosphofructokinase; Region: PFKA_ATP; TIGR02482 443906001656 phosphofructokinase; Region: PFK_mixed; TIGR02483 443906001657 active site 443906001658 ADP/pyrophosphate binding site [chemical binding]; other site 443906001659 dimerization interface [polypeptide binding]; other site 443906001660 allosteric effector site; other site 443906001661 fructose-1,6-bisphosphate binding site; other site 443906001662 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 443906001663 nucleoside triphosphate hydrolase domain-containing protein; Reviewed; Region: PRK09270 443906001664 Nucleoside/nucleotide kinase (NK) is a protein superfamily consisting of multiple families of enzymes that share structural similarity and are functionally related to the catalysis of the reversible phosphate group transfer from nucleoside triphosphates...; Region: NK; cl17190 443906001665 active site 443906001666 Walker A motif; other site 443906001667 ATP binding site [chemical binding]; other site 443906001668 Uncharacterized stress protein (general stress protein 26) [General function prediction only]; Region: COG3871 443906001669 Pyridoxamine 5'-phosphate oxidase; Region: Pyridox_oxidase; pfam01243 443906001670 3-methyladenine DNA glycosylase/8-oxoguanine DNA glycosylase [DNA replication, recombination, and repair]; Region: AlkA; COG0122 443906001671 endonuclease III; includes endonuclease III (DNA-(apurinic or apyrimidinic site) lyase), alkylbase DNA glycosidases (Alka-family) and other DNA glycosidases; Region: ENDO3c; cd00056 443906001672 minor groove reading motif; other site 443906001673 helix-hairpin-helix signature motif; other site 443906001674 active site 443906001675 DSBA-like thioredoxin domain; Region: DSBA; pfam01323 443906001676 DsbA family; consists of DsbA and DsbA-like proteins, including DsbC, DsbG, glutathione (GSH) S-transferase kappa (GSTK), 2-hydroxychromene-2-carboxylate (HCCA) isomerase, an oxidoreductase (FrnE) presumed to be involved in frenolicin biosynthesis, a...; Region: DsbA_family; cd02972 443906001677 catalytic residues [active] 443906001678 Aldose 1-epimerase, similar to Escherichia coli YihR; Region: Aldose_epim_Ec_YihR; cd09022 443906001679 active site 443906001680 catalytic residues [active] 443906001681 This domain superfamily is found in a variety of structurally related metalloproteins, including the type I extradiol dioxygenases, glyoxalase I and a group of antibiotic resistance proteins; Region: Glo_EDI_BRP_like; cl14632 443906001682 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 443906001683 active site 443906001684 metal binding site [ion binding]; metal-binding site 443906001685 helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347 443906001686 MarR family; Region: MarR; pfam01047 443906001687 Beta-fructosidases (levanase/invertase) [Carbohydrate transport and metabolism]; Region: SacC; COG1621 443906001688 Glycosyl hydrolase family 32, beta-fructosidases; Region: GH32_B_Fructosidase; cd08996 443906001689 substrate binding [chemical binding]; other site 443906001690 active site 443906001691 Glycosyl hydrolase family 68, includes levansucrase, beta-fructofuranosidase and inulosucrase; Region: GH68; cd08997 443906001692 active site 443906001693 Reeler-like domain of YcnI and similar proteins; Region: YcnI_like; cd08545 443906001694 CopC domain; Region: CopC; pfam04234 443906001695 Transcriptional regulator [Transcription]; Region: LysR; COG0583 443906001696 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 443906001697 The C-terminal substrate binding domain of an uncharacterized LysR-type transcriptional regulator, contains the type 2 periplasmic binding fold; Region: PBP2_LTTR_like_6; cd08423 443906001698 putative dimerization interface [polypeptide binding]; other site 443906001699 Proline dehydrogenase; Region: Pro_dh; cl03282 443906001700 Delta(1)-pyrroline-5-carboxylate dehydrogenase, PutA; Region: ALDH_PutA-P5CDH; cd07125 443906001701 Aldehyde dehydrogenase family; Region: Aldedh; pfam00171 443906001702 Glutamate binding site [chemical binding]; other site 443906001703 NAD binding site [chemical binding]; other site 443906001704 catalytic residues [active] 443906001705 Peptidase family M1; Region: Peptidase_M1; pfam01433 443906001706 Peptidase M1 family Aminopeptidase N; Region: M1_APN_4; cd09603 443906001707 Zn binding site [ion binding]; other site 443906001708 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 443906001709 amino acid adenylation domain; Region: AA-adenyl-dom; TIGR01733 443906001710 acyl-activating enzyme (AAE) consensus motif; other site 443906001711 AMP binding site [chemical binding]; other site 443906001712 active site 443906001713 CoA binding site [chemical binding]; other site 443906001714 Phosphopantetheine attachment site; Region: PP-binding; pfam00550 443906001715 non-ribosomal peptide synthetase terminal domain of unknown function; Region: NRPS_term_dom; TIGR02353 443906001716 Left-handed parallel beta-Helix (LbetaH or LbH) domain: The alignment contains 5 turns, each containing three imperfect tandem repeats of a hexapeptide repeat motif (X-[STAV]-X-[LIV]-[GAED]-X). Proteins containing hexapeptide repeats are often enzymes...; Region: LbetaH; cl00160 443906001717 putative trimer interface [polypeptide binding]; other site 443906001718 putative CoA binding site [chemical binding]; other site 443906001719 Left-handed parallel beta-Helix (LbetaH or LbH) domain: The alignment contains 5 turns, each containing three imperfect tandem repeats of a hexapeptide repeat motif (X-[STAV]-X-[LIV]-[GAED]-X). Proteins containing hexapeptide repeats are often enzymes...; Region: LbetaH; cl00160 443906001720 putative trimer interface [polypeptide binding]; other site 443906001721 putative CoA binding site [chemical binding]; other site 443906001722 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 443906001723 DNA-binding site [nucleotide binding]; DNA binding site 443906001724 Bacterial Ig-like domain; Region: Big_5; pfam13205 443906001725 PA14 domain; Region: PA14; cl08459 443906001726 domain in bacterial beta-glucosidases other glycosidases, glycosyltransferases, proteases, amidases, yeast adhesins, and bacterial toxins; Region: PA14; smart00758 443906001727 RHS repeat-associated core domain; Region: Rhs_assc_core; TIGR03696 443906001728 Transcriptional regulators [Transcription]; Region: Lrp; COG1522 443906001729 AsnC-type helix-turn-helix domain; Region: HTH_AsnC-type; pfam13404 443906001730 AsnC family; Region: AsnC_trans_reg; pfam01037 443906001731 N-Dimethylarginine dimethylaminohydrolase [Amino acid transport and metabolism]; Region: COG1834 443906001732 Amidinotransferase; Region: Amidinotransf; pfam02274 443906001733 ornithine--oxo-acid transaminase; Provisional; Region: rocD; PRK04073 443906001734 Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610 443906001735 inhibitor-cofactor binding pocket; inhibition site 443906001736 pyridoxal 5'-phosphate binding site [chemical binding]; other site 443906001737 catalytic residue [active] 443906001738 Threonine/homoserine efflux transporter [Amino acid transport and metabolism]; Region: rhtA; COG5006 443906001739 EamA-like transporter family; Region: EamA; pfam00892 443906001740 Nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: WcaG; COG0451 443906001741 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 443906001742 NAD(P) binding site [chemical binding]; other site 443906001743 active site 443906001744 benzoate transporter; Region: benE; TIGR00843 443906001745 benzoate transporter; Region: benE; TIGR00843 443906001746 Membrane proteins related to metalloendopeptidases [Cell envelope biogenesis, outer membrane]; Region: NlpD; COG0739 443906001747 Peptidase family M23; Region: Peptidase_M23; pfam01551 443906001748 SGNH_hydrolase subfamily, FeeA, FeeB and similar esterases/lipases. FeeA and FeeB are part of a biosynthetic gene cluster and may participate in the biosynthesis of long-chain N-acyltyrosines by providing saturated and unsaturated fatty acids, which it...; Region: FeeA_FeeB_like; cd01836 443906001749 active site 443906001750 catalytic triad [active] 443906001751 oxyanion hole [active] 443906001752 Ligand-binding SRPBCC domain of an uncharacterized subfamily of proteins; Region: SRPBCC_8; cd07817 443906001753 putative hydrophobic ligand binding site [chemical binding]; other site 443906001754 RDD family; Region: RDD; pfam06271 443906001755 NADH:flavin oxidoreductases, Old Yellow Enzyme family [Energy production and conversion]; Region: NemA; COG1902 443906001756 Old yellow enzyme (OYE)-like FMN binding domain. OYE was the first flavin-dependent enzyme identified, however its true physiological role remains elusive to this day. Each monomer of OYE contains FMN as a non-covalently bound cofactor, uses NADPH as a...; Region: OYE_like_FMN; cd02933 443906001757 FMN binding site [chemical binding]; other site 443906001758 active site 443906001759 substrate binding site [chemical binding]; other site 443906001760 catalytic residue [active] 443906001761 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 443906001762 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 443906001763 active site 443906001764 phosphorylation site [posttranslational modification] 443906001765 intermolecular recognition site; other site 443906001766 dimerization interface [polypeptide binding]; other site 443906001767 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 443906001768 DNA binding residues [nucleotide binding] 443906001769 dimerization interface [polypeptide binding]; other site 443906001770 Histidine kinase; Region: HisKA_3; pfam07730 443906001771 Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase; Region: HATPase_c; pfam02518 443906001772 Putative transmembrane protein (PGPGW); Region: PGPGW; pfam09656 443906001773 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 443906001774 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 443906001775 Major Facilitator Superfamily; Region: MFS_1; pfam07690 443906001776 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 443906001777 putative substrate translocation pore; other site 443906001778 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 443906001779 putative FMN-dependent luciferase-like monooxygenase, KPN_01858 family; Region: LLM_KPN_01858; TIGR04027 443906001780 probable oxidoreductase, LLM family; Region: LLM_2I7G; TIGR03858 443906001781 Luciferase-like monooxygenase; Region: Bac_luciferase; pfam00296 443906001782 probable oxidoreductase, LLM family; Region: LLM_2I7G; TIGR03858 443906001783 quinone oxidoreductase, NADPH-dependent; Provisional; Region: PRK10754 443906001784 Quinone oxidoreductase (QOR); Region: QOR2; cd05286 443906001785 NADP binding site [chemical binding]; other site 443906001786 dimer interface [polypeptide binding]; other site 443906001787 Cysteine synthase [Amino acid transport and metabolism]; Region: CysK; COG0031 443906001788 CBS_like: This subgroup includes Cystathionine beta-synthase (CBS) and Cysteine synthase. CBS is a unique heme-containing enzyme that catalyzes a pyridoxal 5'-phosphate (PLP)-dependent condensation of serine and homocysteine to give cystathionine; Region: CBS_like; cd01561 443906001789 dimer interface [polypeptide binding]; other site 443906001790 pyridoxal 5'-phosphate binding site [chemical binding]; other site 443906001791 catalytic residue [active] 443906001792 serine O-acetyltransferase; Region: cysE; TIGR01172 443906001793 Serine acetyltransferase (SAT): SAT catalyzes the CoA-dependent acetylation of the side chain hydroxyl group of L-serine to form O-acetylserine, as the first step of a two-step biosynthetic pathway in bacteria and plants leading to the formation of...; Region: LbH_SAT; cd03354 443906001794 trimer interface [polypeptide binding]; other site 443906001795 active site 443906001796 substrate binding site [chemical binding]; other site 443906001797 CoA binding site [chemical binding]; other site 443906001798 SpoU rRNA Methylase family; Region: SpoU_methylase; pfam00588 443906001799 Uncharacterized protein family (UPF0157); Region: UPF0157; pfam04229 443906001800 YjgF, YER057c, and UK114 belong to a large family of proteins present in bacteria, archaea, and eukaryotes with no definitive function. The conserved domain is similar in structure to chorismate mutase but there is no sequence similarity and no...; Region: YjgF_YER057c_UK114_family; cd00448 443906001801 homotrimer interaction site [polypeptide binding]; other site 443906001802 putative active site [active] 443906001803 Adenosine deaminase [Nucleotide transport and metabolism]; Region: Add; COG1816 443906001804 adenosine deaminase; Provisional; Region: PRK09358 443906001805 active site 443906001806 NACHT domain; Region: NACHT; pfam05729 443906001807 AAA ATPase domain; Region: AAA_16; pfam13191 443906001808 Zn-dependent alcohol dehydrogenases [General function prediction only]; Region: AdhP; COG1064 443906001809 Cinnamyl alcohol dehydrogenases (CAD); Region: CAD1; cd05283 443906001810 putative NAD(P) binding site [chemical binding]; other site 443906001811 putative substrate binding site [chemical binding]; other site 443906001812 catalytic Zn binding site [ion binding]; other site 443906001813 structural Zn binding site [ion binding]; other site 443906001814 dimer interface [polypeptide binding]; other site 443906001815 Esterases and lipases (includes fungal lipases, cholinesterases, etc.) These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cd00312 443906001816 substrate binding pocket [chemical binding]; other site 443906001817 catalytic triad [active] 443906001818 redox-sensitive transcriptional activator SoxR; Region: SoxR; TIGR01950 443906001819 Helix-Turn-Helix DNA binding domain of transcription regulators from the MerR superfamily; Region: HTH_MerR-SF; cl02600 443906001820 DNA binding residues [nucleotide binding] 443906001821 Ferredoxin [Energy production and conversion]; Region: COG1146 443906001822 4Fe-4S binding domain; Region: Fer4; pfam00037 443906001823 Flavin reductase like domain; Region: Flavin_Reduct; smart00903 443906001824 Bacillus subtilis YvnB and related proteins, metallophosphatase domain; Region: MPP_YvnB; cd07399 443906001825 Predicted phosphohydrolases [General function prediction only]; Region: Icc; COG1409 443906001826 putative active site [active] 443906001827 putative metal binding site [ion binding]; other site 443906001828 Concanavalin A-like lectin/glucanases superfamily; Region: Laminin_G_3; pfam13385 443906001829 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 443906001830 Zn2+ binding site [ion binding]; other site 443906001831 Mg2+ binding site [ion binding]; other site 443906001832 YhgE/Pip N-terminal domain; Region: pip_yhgE_Nterm; TIGR03061 443906001833 Predicted membrane protein [Function unknown]; Region: COG1511 443906001834 YhgE/Pip C-terminal domain; Region: pip_yhgE_Cterm; TIGR03062 443906001835 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 443906001836 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 443906001837 Helix-turn-helix domain; Region: HTH_18; pfam12833 443906001838 ATPase involved in DNA repair [DNA replication, recombination, and repair]; Region: SbcC; COG0419 443906001839 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 443906001840 Walker A/P-loop; other site 443906001841 ATP binding site [chemical binding]; other site 443906001842 Q-loop/lid; other site 443906001843 ATPase involved in DNA repair [DNA replication, recombination, and repair]; Region: SbcC; COG0419 443906001844 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 443906001845 ABC transporter signature motif; other site 443906001846 Walker B; other site 443906001847 D-loop; other site 443906001848 H-loop/switch region; other site 443906001849 Mre11 nuclease, N-terminal metallophosphatase domain; Region: MPP_Mre11_N; cd00840 443906001850 Calcineurin-like phosphoesterase; Region: Metallophos; pfam00149 443906001851 active site 443906001852 metal binding site [ion binding]; metal-binding site 443906001853 DNA binding site [nucleotide binding] 443906001854 Type 5 capsule protein repressor C-terminal domain; Region: SbcD_C; pfam12320 443906001855 Serine/threonine protein kinase [General function prediction only / Signal transduction mechanisms / Transcription / DNA replication, recombination, and repair]; Region: SPS1; COG0515 443906001856 Aminoglycoside 3'-phosphotransferase (APH) and Choline Kinase (ChoK) family. The APH/ChoK family is part of a larger superfamily that includes the catalytic domains of other kinases, such as the typical serine/threonine/tyrosine protein kinases (PKs)...; Region: APH_ChoK_like; cd05120 443906001857 active site 443906001858 ATP binding site [chemical binding]; other site 443906001859 LanC-like proteins. LanC is the cyclase enzyme of the lanthionine synthetase. Lanthionine is a lantibiotic, a unique class of peptide antibiotics. They are ribosomally synthesized as a precursor peptide and then post-translationally modified to contain...; Region: LanC_like; cl04955 443906001860 active site 443906001861 zinc binding site [ion binding]; other site 443906001862 Acetyltransferases, including N-acetylases of ribosomal proteins [Translation, ribosomal structure and biogenesis]; Region: RimL; COG1670 443906001863 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 443906001864 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 443906001865 active site 443906001866 CoA binding site [chemical binding]; other site 443906001867 AMP binding site [chemical binding]; other site 443906001868 NAD(P)+-dependent aldehyde dehydrogenase superfamily; Region: ALDH-SF; cl11961 443906001869 NAD(P) binding site [chemical binding]; other site 443906001870 catalytic residues [active] 443906001871 beta-ketoacyl-acyl-carrier-protein synthase II; Region: fabF; TIGR03150 443906001872 Beta-ketoacyl-acyl carrier protein (ACP) synthase (KAS), type I and II. KASs are responsible for the elongation steps in fatty acid biosynthesis. KASIII catalyses the initial condensation and KAS I and II catalyze further elongation steps by Claisen...; Region: KAS_I_II; cd00834 443906001873 dimer interface [polypeptide binding]; other site 443906001874 active site 443906001875 Pyrimidine (PYR) binding domain of thiamine pyrophosphate (TPP)-dependent enzymes; Region: TPP_enzyme_PYR; cl11410 443906001876 PYR/PP interface [polypeptide binding]; other site 443906001877 dimer interface [polypeptide binding]; other site 443906001878 TPP binding site [chemical binding]; other site 443906001879 Thiamine pyrophosphate-requiring enzymes [acetolactate synthase, pyruvate dehydrogenase (cytochrome), glyoxylate carboligase, phosphonopyruvate decarboxylase] [Amino acid transport and metabolism / Coenzyme metabolism]; Region: IlvB; COG0028 443906001880 Thiamine pyrophosphate enzyme, central domain; Region: TPP_enzyme_M; pfam00205 443906001881 Thiamine pyrophosphate (TPP) enzyme family, TPP-binding module; found in many key metabolic enzymes which use TPP (also known as thiamine diphosphate) as a cofactor. These enzymes include, among others, the E1 components of the pyruvate, the acetoin and...; Region: TPP_enzymes; cd00568 443906001882 TPP-binding site [chemical binding]; other site 443906001883 Flavoprotein; Region: Flavoprotein; pfam02441 443906001884 ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136 443906001885 ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255 443906001886 Walker A/P-loop; other site 443906001887 ATP binding site [chemical binding]; other site 443906001888 Q-loop/lid; other site 443906001889 ABC transporter signature motif; other site 443906001890 Walker B; other site 443906001891 D-loop; other site 443906001892 H-loop/switch region; other site 443906001893 MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704 443906001894 ABC-type antimicrobial peptide transport system, permease component [Defense mechanisms]; Region: SalY; COG0577 443906001895 FtsX-like permease family; Region: FtsX; pfam02687 443906001896 Protein of unknown function (DUF2910); Region: DUF2910; pfam11139 443906001897 short chain dehydrogenase; Provisional; Region: PRK08263 443906001898 17beta hydroxysteroid dehydrogenase-like, classical (c) SDRs; Region: 17beta-HSD-like_SDR_c; cd05374 443906001899 NADP binding site [chemical binding]; other site 443906001900 active site 443906001901 steroid binding site; other site 443906001902 Protein of unknown function (DUF3151); Region: DUF3151; pfam11349 443906001903 Adenylosuccinate synthetase; Region: Adenylsucc_synt; smart00788 443906001904 Adenylosuccinate synthetase (AdSS) catalyzes the first step in the de novo biosynthesis of AMP. IMP and L-aspartate are conjugated in a two-step reaction accompanied by the hydrolysis of GTP to GDP in the presence of Mg2+. In the first step, the...; Region: AdSS; cd03108 443906001905 GDP-binding site [chemical binding]; other site 443906001906 ACT binding site; other site 443906001907 IMP binding site; other site 443906001908 helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347 443906001909 MarR family; Region: MarR_2; pfam12802 443906001910 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 443906001911 This domain superfamily is found in a variety of structurally related metalloproteins, including the type I extradiol dioxygenases, glyoxalase I and a group of antibiotic resistance proteins; Region: Glo_EDI_BRP_like; cd06587 443906001912 active site 443906001913 Nucleoside/nucleotide kinase (NK) is a protein superfamily consisting of multiple families of enzymes that share structural similarity and are functionally related to the catalysis of the reversible phosphate group transfer from nucleoside triphosphates...; Region: NK; cl17190 443906001914 AAA domain; Region: AAA_18; pfam13238 443906001915 active site 443906001916 Sensors of blue-light using FAD; Region: BLUF; smart01034 443906001917 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 443906001918 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 443906001919 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 443906001920 non-specific DNA binding site [nucleotide binding]; other site 443906001921 salt bridge; other site 443906001922 sequence-specific DNA binding site [nucleotide binding]; other site 443906001923 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 443906001924 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 443906001925 dimer interface [polypeptide binding]; other site 443906001926 phosphorylation site [posttranslational modification] 443906001927 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 443906001928 ATP binding site [chemical binding]; other site 443906001929 Mg2+ binding site [ion binding]; other site 443906001930 G-X-G motif; other site 443906001931 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 443906001932 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 443906001933 active site 443906001934 phosphorylation site [posttranslational modification] 443906001935 intermolecular recognition site; other site 443906001936 dimerization interface [polypeptide binding]; other site 443906001937 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 443906001938 DNA binding site [nucleotide binding] 443906001939 Acetyltransferases, including N-acetylases of ribosomal proteins [Translation, ribosomal structure and biogenesis]; Region: RimL; COG1670 443906001940 This conserved domain belongs to a superfamily including the bleomycin resistance protein, glyoxalase I, and type I ring-cleaving dioxygenases; Region: Glo_EDI_BRP_like_6; cd07242 443906001941 putative dimer interface [polypeptide binding]; other site 443906001942 ligand binding site [chemical binding]; other site 443906001943 Zn binding site [ion binding]; other site 443906001944 Beta-lactamase; Region: Beta-lactamase; pfam00144 443906001945 Beta-lactamase class C and other penicillin binding proteins [Defense mechanisms]; Region: AmpC; COG1680 443906001946 Histidine kinase; Region: HisKA_3; pfam07730 443906001947 Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase; Region: HATPase_c; pfam02518 443906001948 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 443906001949 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 443906001950 active site 443906001951 phosphorylation site [posttranslational modification] 443906001952 intermolecular recognition site; other site 443906001953 dimerization interface [polypeptide binding]; other site 443906001954 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 443906001955 DNA binding residues [nucleotide binding] 443906001956 dimerization interface [polypeptide binding]; other site 443906001957 peroxiredoxin, Ohr subfamily; Region: organ_hyd_perox; TIGR03561 443906001958 chorismate mutase; Provisional; Region: PRK09239 443906001959 Lysine biosynthesis enzyme LysX; Region: LysX_arch; TIGR02144 443906001960 ATP-grasp domain; Region: ATP-grasp_4; cl17255 443906001961 Exonuclease-Endonuclease-Phosphatase domain; uncharacterized family 1; Region: EEP-1; cd09083 443906001962 putative catalytic site [active] 443906001963 putative metal binding site [ion binding]; other site 443906001964 putative phosphate binding site [ion binding]; other site 443906001965 YdcF-like. YdcF-like is a large family of mainly bacterial proteins, with a few members found in fungi, plants, and archaea. Escherichia coli YdcF has been shown to bind S-adenosyl-L-methionine (AdoMet), but a biochemical function has not been...; Region: YdcF-like; cd06259 443906001966 putative active site [active] 443906001967 Protein of unknown function (DUF4012); Region: DUF4012; pfam13196 443906001968 Polysaccharide pyruvyl transferase; Region: PS_pyruv_trans; pfam04230 443906001969 This family is most closely related to the GT1 family of glycosyltransferases. mtfB (mannosyltransferase B) in E. coli has been shown to direct the growth of the O9-specific polysaccharide chain. It transfers two mannoses into the position 3 of the...; Region: GT1_mtfB_like; cd03809 443906001970 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 443906001971 This family is most closely related to the GT1 family of glycosyltransferases. wbaZ in Salmonella enterica has been shown to possess the mannosyl transferase activity. The members of this family are found in certain bacteria and Archaea; Region: GT1_wbaZ_like; cd03804 443906001972 putative ADP-binding pocket [chemical binding]; other site 443906001973 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 443906001974 exopolysaccharide biosynthesis polyprenyl glycosylphosphotransferase; Region: EPS_sugtrans; TIGR03025 443906001975 Bacterial sugar transferase; Region: Bac_transf; pfam02397 443906001976 Low molecular weight phosphatase family; Region: LMWPc; cl00105 443906001977 Protein-tyrosine-phosphatase [Signal transduction mechanisms]; Region: Wzb; COG0394 443906001978 active site 443906001979 Chain length determinant protein; Region: Wzz; cl15801 443906001980 capsular exopolysaccharide family; Region: eps_fam; TIGR01007 443906001981 The Fer4_NifH superfamily contains a variety of proteins which share a common ATP-binding domain. Functionally, proteins in this superfamily use the energy from hydrolysis of NTP to transfer electron or ion; Region: Fer4_NifH; cl17203 443906001982 Predicted acyltransferases [Lipid metabolism]; Region: COG1835 443906001983 Predicted acyltransferases [Lipid metabolism]; Region: COG1835 443906001984 SGNH_hydrolase, or GDSL_hydrolase, is a diverse family of lipases and esterases. The tertiary fold of the enzyme is substantially different from that of the alpha/beta hydrolase family and unique among all known hydrolases; its active site closely...; Region: SGNH_hydrolase; cl01053 443906001985 active site 443906001986 catalytic triad [active] 443906001987 oxyanion hole [active] 443906001988 Exonuclease-Endonuclease-Phosphatase domain; uncharacterized family 1; Region: EEP-1; cd09083 443906001989 putative catalytic site [active] 443906001990 putative metal binding site [ion binding]; other site 443906001991 putative phosphate binding site [ion binding]; other site 443906001992 Dienelactone hydrolase and related enzymes [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG0412 443906001993 BAAT / Acyl-CoA thioester hydrolase C terminal; Region: BAAT_C; pfam08840 443906001994 phosphoribosylformylglycinamidine synthase II; Provisional; Region: PRK01213 443906001995 PurL subunit of the formylglycinamide ribonucleotide amidotransferase (FGAR-AT), first repeat. FGAR-AT catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to formylglycinamidine ribonucleotide (FGAM), ADP; Region: PurL_repeat1; cd02203 443906001996 dimerization interface [polypeptide binding]; other site 443906001997 ATP binding site [chemical binding]; other site 443906001998 PurL subunit of the formylglycinamide ribonucleotide amidotransferase (FGAR-AT), second repeat. FGAR-AT catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to formylglycinamidine ribonucleotide (FGAM), ADP; Region: PurL_repeat2; cd02204 443906001999 dimerization interface [polypeptide binding]; other site 443906002000 ATP binding site [chemical binding]; other site 443906002001 phosphoribosylformylglycinamidine synthase I; Provisional; Region: PRK03619 443906002002 Type 1 glutamine amidotransferase (GATase1)-like domain found in Formylglycinamide ribonucleotide amidotransferase; Region: GATase1_FGAR_AT; cd01740 443906002003 putative active site [active] 443906002004 catalytic triad [active] 443906002005 phosphoribosylformylglycinamidine synthase subunit PurS; Reviewed; Region: PRK05974 443906002006 Protein of unknown function (DUF2848); Region: DUF2848; pfam11010 443906002007 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 443906002008 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 443906002009 Transcriptional regulators [Transcription]; Region: FadR; COG2186 443906002010 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cl17414 443906002011 DNA-binding site [nucleotide binding]; DNA binding site 443906002012 FCD domain; Region: FCD; pfam07729 443906002013 Predicted amidohydrolase [General function prediction only]; Region: COG0388 443906002014 Uncharacterized subgroup of the nitrilase superfamily (putative class 13 nitrilases); Region: nitrilase_3; cd07581 443906002015 putative active site [active] 443906002016 catalytic triad [active] 443906002017 putative dimer interface [polypeptide binding]; other site 443906002018 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 443906002019 Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248 443906002020 active site 443906002021 catalytic tetrad [active] 443906002022 Ferric uptake regulator(Fur) and related metalloregulatory proteins; typically iron-dependent, DNA-binding repressors and activators; Region: Fur_like; cd07153 443906002023 metal binding site 2 [ion binding]; metal-binding site 443906002024 putative DNA binding helix; other site 443906002025 metal binding site 1 [ion binding]; metal-binding site 443906002026 dimer interface [polypeptide binding]; other site 443906002027 structural Zn2+ binding site [ion binding]; other site 443906002028 Catalase [Inorganic ion transport and metabolism]; Region: KatE; COG0753 443906002029 Clade 3 of the heme-binding enzyme catalase; Region: catalase_clade_3; cd08156 443906002030 tetramer interface [polypeptide binding]; other site 443906002031 heme binding pocket [chemical binding]; other site 443906002032 NADPH binding site [chemical binding]; other site 443906002033 Acetyltransferases [General function prediction only]; Region: RimI; COG0456 443906002034 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 443906002035 Coenzyme A binding pocket [chemical binding]; other site 443906002036 Nodulation protein A (NodA); Region: NodA; cl17421 443906002037 Predicted permease, member of the PurR regulon [General function prediction only]; Region: yhhT; COG0628 443906002038 Phenazine biosynthesis-like protein; Region: PhzC-PhzF; pfam02567 443906002039 Hemolysins and related proteins containing CBS domains [General function prediction only]; Region: TlyC; COG1253 443906002040 Domain of unknown function DUF21; Region: DUF21; pfam01595 443906002041 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains associated with the CorC_HlyC domain. CorC_HlyC is a transporter associated domain. This small domain is found in Na+/H+ antiporters, in proteins involved in...; Region: CBS_pair_CorC_HlyC_assoc; cd04590 443906002042 Transporter associated domain; Region: CorC_HlyC; smart01091 443906002043 Nucleoside/nucleotide kinase (NK) is a protein superfamily consisting of multiple families of enzymes that share structural similarity and are functionally related to the catalysis of the reversible phosphate group transfer from nucleoside triphosphates...; Region: NK; cl17190 443906002044 Intradiol dioxygenase supgroup. Intradiol dioxygenases catalyze the critical ring-cleavage step in the conversion of catecholate derivatives to citric acid cycle intermediates. They break the catechol C1-C2 bond and utilize Fe3+, as opposed to the...; Region: intradiol_dioxygenase_like; cd03457 443906002045 putative active site [active] 443906002046 hypothetical protein; Provisional; Region: PRK07236 443906002047 hypothetical protein; Provisional; Region: PRK07588 443906002048 MarR family; Region: MarR_2; pfam12802 443906002049 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394 443906002050 Glycosyltransferases, probably involved in cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: COG1215 443906002051 active site 443906002052 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 443906002053 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 443906002054 GlcNAc-PI de-N-acetylase; Region: PIG-L; cl00929 443906002055 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 443906002056 S-adenosylmethionine binding site [chemical binding]; other site 443906002057 non-metazoan 5-aminoimidazole-4-(N-succinylcarboxamide) ribonucleotide (SAICAR) synthase; Region: SAICAR_synt_Sc; cd01414 443906002058 active site 443906002059 ATP binding site [chemical binding]; other site 443906002060 substrate binding site [chemical binding]; other site 443906002061 phosphoribosylamine--glycine ligase; Provisional; Region: PRK00885 443906002062 Phosphoribosylglycinamide synthetase, N domain; Region: GARS_N; pfam02844 443906002063 Phosphoribosylglycinamide synthetase, ATP-grasp (A) domain; Region: GARS_A; pfam01071 443906002064 Phosphoribosylglycinamide synthetase, C domain; Region: GARS_C; pfam02843 443906002065 amidophosphoribosyltransferase; Provisional; Region: PRK09246 443906002066 Glutamine amidotransferases class-II (GN-AT)_GPAT- type. This domain is found at the N-terminus of glutamine phosphoribosylpyrophosphate (Prpp) amidotransferase (GPATase) . The glutaminase domain catalyzes amide nitrogen transfer from glutamine to the...; Region: GPATase_N; cd00715 443906002067 active site 443906002068 tetramer interface [polypeptide binding]; other site 443906002069 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 443906002070 active site 443906002071 phosphoribosylaminoimidazole synthetase; Provisional; Region: PRK05385 443906002072 PurM (Aminoimidazole Ribonucleotide [AIR] synthetase), one of eleven enzymes required for purine biosynthesis, catalyzes the conversion of formylglycinamide ribonucleotide (FGAM) and ATP to AIR, ADP, and Pi, the fifth step in de novo purine biosynthesis; Region: PurM; cd02196 443906002073 dimerization interface [polypeptide binding]; other site 443906002074 putative ATP binding site [chemical binding]; other site 443906002075 Protein of unknown function (DUF3073); Region: DUF3073; pfam11273 443906002076 Predicted flavoprotein involved in K+ transport [Inorganic ion transport and metabolism]; Region: TrkA; COG2072 443906002077 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500 443906002078 Amino acid transporters [Amino acid transport and metabolism]; Region: PotE; COG0531 443906002079 Uncharacterized BCR, YitT family COG1284; Region: DUF161; pfam02588 443906002080 Predicted membrane protein [Function unknown]; Region: COG2364 443906002081 Uncharacterized BCR, YitT family COG1284; Region: DUF161; pfam02588 443906002082 Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain (MocR family) and their eukaryotic orthologs [Transcription / Amino acid transport and metabolism]; Region: ARO8; COG1167 443906002083 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 443906002084 DNA-binding site [nucleotide binding]; DNA binding site 443906002085 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 443906002086 pyridoxal 5'-phosphate binding site [chemical binding]; other site 443906002087 homodimer interface [polypeptide binding]; other site 443906002088 catalytic residue [active] 443906002089 Trypsin-like serine protease; Many of these are synthesized as inactive precursor zymogens that are cleaved during limited proteolysis to generate their active forms. Alignment contains also inactive enzymes that have substitutions of the catalytic triad...; Region: Tryp_SPc; cl00149 443906002090 glycogen debranching enzyme GlgX; Region: glgX_debranch; TIGR02100 443906002091 N-terminal Early set domain associated with the catalytic domain of Glycogen debranching enzyme and bacterial isoamylase (also called glycogen 6-glucanohydrolase); Region: E_set_GDE_Isoamylase_N; cd02856 443906002092 Alpha amylase catalytic domain found in glycogen debranching enzymes; Region: AmyAc_Glg_debranch; cd11326 443906002093 active site 443906002094 catalytic site [active] 443906002095 Fusaric acid resistance protein-like; Region: FUSC_2; pfam13515 443906002096 Uncharacterized protein conserved in bacteria (DUF2256); Region: DUF2256; pfam10013 443906002097 Protein of unknown function (DUF3253); Region: DUF3253; pfam11625 443906002098 Cation/multidrug efflux pump [Defense mechanisms]; Region: AcrB; COG0841 443906002099 Cation/multidrug efflux pump [Defense mechanisms]; Region: AcrB; COG0841 443906002100 DEAD-box helicases. A diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker B motif; Region: DEADc; cd00268 443906002101 DEAD-like helicases superfamily; Region: DEXDc; smart00487 443906002102 ATP binding site [chemical binding]; other site 443906002103 Mg++ binding site [ion binding]; other site 443906002104 motif III; other site 443906002105 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 443906002106 nucleotide binding region [chemical binding]; other site 443906002107 ATP-binding site [chemical binding]; other site 443906002108 Acetyltransferase (GNAT) domain; Region: Acetyltransf_3; pfam13302 443906002109 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl17182 443906002110 Acetyltransferase (GNAT) domain; Region: Acetyltransf_10; pfam13673 443906002111 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 443906002112 Coenzyme A binding pocket [chemical binding]; other site 443906002113 Sugar kinases, ribokinase family [Carbohydrate transport and metabolism]; Region: RbsK; COG0524 443906002114 2-keto-3-deoxygluconate kinase (KdgK) phosphorylates 2-keto-3-deoxygluconate (KDG) to form 2-keto-3-deoxy-6-phosphogluconate (KDGP). KDG is the common intermediate product, that allows organisms to channel D-glucuronate and/or D-galacturinate into the...; Region: KdgK; cd01166 443906002115 substrate binding site [chemical binding]; other site 443906002116 ATP binding site [chemical binding]; other site 443906002117 Methylmalonate semialdehyde dehydrogenase and ALDH family members 6A1 and 6B2; Region: ALDH_F6_MMSDH; cd07085 443906002118 methylmalonic acid semialdehyde dehydrogenase; Region: MMSDH; TIGR01722 443906002119 tetrameric interface [polypeptide binding]; other site 443906002120 NAD binding site [chemical binding]; other site 443906002121 catalytic residues [active] 443906002122 KduI/IolB family; Region: KduI; pfam04962 443906002123 Acetolactate synthase [Amino acid transport and metabolism]; Region: COG3962 443906002124 Pyrimidine (PYR) binding domain of POX and related proteins; Region: TPP_PYR_POX_like; cd07035 443906002125 PYR/PP interface [polypeptide binding]; other site 443906002126 dimer interface [polypeptide binding]; other site 443906002127 TPP binding site [chemical binding]; other site 443906002128 Thiamine pyrophosphate enzyme, central domain; Region: TPP_enzyme_M; pfam00205 443906002129 Thiamine pyrophosphate (TPP) family, IolD subfamily, TPP-binding module; composed of proteins similar to Rhizobium leguminosarum bv. viciae IolD. IolD plays an important role in myo-inositol catabolism; Region: TPP_IolD; cd02003 443906002130 TPP-binding site; other site 443906002131 Xylose isomerase-like TIM barrel; Region: AP_endonuc_2; pfam01261 443906002132 3-hydroxyacyl-CoA dehydrogenase [Lipid metabolism]; Region: FadB; COG1250 443906002133 3-hydroxyacyl-CoA dehydrogenase, NAD binding domain; Region: 3HCDH_N; pfam02737 443906002134 3-hydroxyacyl-CoA dehydrogenase, C-terminal domain; Region: 3HCDH; pfam00725 443906002135 Short-chain dehydrogenase involved in D-alanine esterification of lipoteichoic acid and wall teichoic acid (D-alanine transfer protein) [Cell envelope biogenesis, outer membrane]; Region: DltE; COG3967 443906002136 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 443906002137 NAD(P) binding site [chemical binding]; other site 443906002138 active site 443906002139 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 443906002140 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 443906002141 salt bridge; other site 443906002142 non-specific DNA binding site [nucleotide binding]; other site 443906002143 sequence-specific DNA binding site [nucleotide binding]; other site 443906002144 Transcriptional regulators [Transcription]; Region: GntR; COG1802 443906002145 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 443906002146 DNA-binding site [nucleotide binding]; DNA binding site 443906002147 FCD domain; Region: FCD; pfam07729 443906002148 Triosephosphate isomerase (TIM) is a glycolytic enzyme that catalyzes the interconversion of dihydroxyacetone phosphate and D-glyceraldehyde-3-phosphate. The reaction is very efficient and requires neither cofactors nor metal ions. TIM, usually...; Region: TIM; cd00311 443906002149 substrate binding site [chemical binding]; other site 443906002150 dimer interface [polypeptide binding]; other site 443906002151 catalytic triad [active] 443906002152 Ribose/Galactose Isomerase; Region: LacAB_rpiB; pfam02502 443906002153 dihydroxyacetone kinase; Provisional; Region: PRK14479 443906002154 dihydroxyacetone kinase subunit DhaK; Provisional; Region: PRK14481; cl10557 443906002155 DAK2 domain; Region: Dak2; pfam02734 443906002156 Transcriptional regulators [Transcription]; Region: PhnF; COG2188 443906002157 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 443906002158 DNA-binding site [nucleotide binding]; DNA binding site 443906002159 UTRA domain; Region: UTRA; pfam07702 443906002160 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 443906002161 urea ABC transporter, ATP-binding protein UrtE; Region: urea_trans_UrtE; TIGR03410 443906002162 Walker A/P-loop; other site 443906002163 ATP binding site [chemical binding]; other site 443906002164 Q-loop/lid; other site 443906002165 ABC transporter signature motif; other site 443906002166 Walker B; other site 443906002167 D-loop; other site 443906002168 H-loop/switch region; other site 443906002169 Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653 443906002170 Transmembrane subunit (TM) of Escherichia coli AraH and related proteins. E. coli AraH is the TM of a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of the monosaccharide arabinose. This group...; Region: TM_PBP1_transp_AraH_like; cd06579 443906002171 TM-ABC transporter signature motif; other site 443906002172 Periplasmic sugar-binding domain of uncharacterized ABC-type transport systems; Region: PBP1_ABC_sugar_binding_like_4; cd06312 443906002173 Periplasmic binding protein domain; Region: Peripla_BP_4; pfam13407 443906002174 putative ligand binding site [chemical binding]; other site 443906002175 Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673 443906002176 Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408 443906002177 Oxidoreductase family, C-terminal alpha/beta domain; Region: GFO_IDH_MocA_C; pfam02894 443906002178 Sugar phosphate isomerases/epimerases [Carbohydrate transport and metabolism]; Region: IolE; COG1082 443906002179 YhcR_OBF_like: A subfamily of OB-fold domains similar to the OB folds of Bacillus subtilis YhcR. YhcR is a sugar-nonspecific nuclease, which is active in the presence of Ca2+ and Mn2+. It cleaves RNA endonucleolytically, producing 3'-monophosphate...; Region: YhcR_OBF_like; cd04486 443906002180 generic binding surface II; other site 443906002181 generic binding surface I; other site 443906002182 Mycoplasma pulmonis MnuA nuclease-like; Region: MnuA_DNase1-like; cd10283 443906002183 putative active site [active] 443906002184 putative catalytic site [active] 443906002185 putative Mg binding site IVb [ion binding]; other site 443906002186 putative phosphate binding site [ion binding]; other site 443906002187 putative DNA binding site [nucleotide binding]; other site 443906002188 putative Mg binding site IVa [ion binding]; other site 443906002189 TRX family; composed of two groups: Group I, which includes proteins that exclusively encode a TRX domain; and Group II, which are composed of fusion proteins of TRX and additional domains. Group I TRX is a small ancient protein that alter the redox...; Region: TRX_family; cd02947 443906002190 catalytic residues [active] 443906002191 ATP-dependent DNA helicase RecQ; Region: recQ; TIGR01389 443906002192 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 443906002193 ATP binding site [chemical binding]; other site 443906002194 putative Mg++ binding site [ion binding]; other site 443906002195 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 443906002196 nucleotide binding region [chemical binding]; other site 443906002197 ATP-binding site [chemical binding]; other site 443906002198 This DNA-binding domain is found in the RecQ helicase among others and has a helix-turn-helix structure; Region: RQC; smart00956 443906002199 HRDC domain; Region: HRDC; pfam00570 443906002200 Putative glycosyl hydrolase of unknown function (DUF1680); Region: DUF1680; pfam07944 443906002201 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3533 443906002202 The substrate-binding domain of an oligopeptide binding protein (OppA2) from the biosynthesis pathway of the beta-lactamase inhibitor clavulanic acid contains the type 2 periplasmic binding fold; Region: PBP2_clavulanate_OppA2; cd08506 443906002203 peptide binding site [polypeptide binding]; other site 443906002204 Bacterial extracellular solute-binding proteins, family 5 Middle; Region: SBP_bac_5; pfam00496 443906002205 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppC; COG1173 443906002206 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 443906002207 dimer interface [polypeptide binding]; other site 443906002208 conserved gate region; other site 443906002209 putative PBP binding loops; other site 443906002210 ABC-ATPase subunit interface; other site 443906002211 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppB; COG0601 443906002212 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 443906002213 dimer interface [polypeptide binding]; other site 443906002214 conserved gate region; other site 443906002215 putative PBP binding loops; other site 443906002216 ABC-ATPase subunit interface; other site 443906002217 ABC-type dipeptide/oligopeptide/nickel transport system, ATPase component [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppF; COG1124 443906002218 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 443906002219 Walker A/P-loop; other site 443906002220 ATP binding site [chemical binding]; other site 443906002221 Q-loop/lid; other site 443906002222 ABC transporter signature motif; other site 443906002223 Walker B; other site 443906002224 D-loop; other site 443906002225 H-loop/switch region; other site 443906002226 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097 443906002227 ABC-type dipeptide/oligopeptide/nickel transport system, ATPase component [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppF; COG1124 443906002228 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 443906002229 Walker A/P-loop; other site 443906002230 ATP binding site [chemical binding]; other site 443906002231 Q-loop/lid; other site 443906002232 ABC transporter signature motif; other site 443906002233 Walker B; other site 443906002234 D-loop; other site 443906002235 H-loop/switch region; other site 443906002236 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; pfam08352 443906002237 proline iminopeptidase, Neisseria-type subfamily; Region: pro_imino_pep_1; TIGR01249 443906002238 Aminopeptidase P, N-terminal domain; Region: AMP_N; smart01011 443906002239 Xaa-Pro aminopeptidase [Amino acid transport and metabolism]; Region: PepP; COG0006 443906002240 Prolidase. E.C. 3.4.13.9. Also known as Xaa-Pro dipeptidase, X-Pro dipeptidase, proline dipeptidase., imidodipeptidase, peptidase D, gamma-peptidase. Catalyses hydrolysis of Xaa-Pro dipeptides; also acts on aminoacyl-hydroxyproline analogs. No action on...; Region: Prolidase; cd01087 443906002241 active site 443906002242 phosphonate utilization associated transcriptional regulator; Region: phnR_burk; TIGR03338 443906002243 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 443906002244 DNA-binding site [nucleotide binding]; DNA binding site 443906002245 FCD domain; Region: FCD; pfam07729 443906002246 glycine oxidase ThiO; Region: thiamin_ThiO; TIGR02352 443906002247 2Fe-2S iron-sulfur cluster binding domain; Region: Fer2_4; pfam13510 443906002248 sarcosine oxidase, alpha subunit family, heterotetrameric form; Region: soxA; TIGR01372 443906002249 Dihydrodipicolinate synthase/N-acetylneuraminate lyase [Amino acid transport and metabolism / Cell envelope biogenesis, outer membrane]; Region: DapA; COG0329 443906002250 Dihydrodipicolinate synthase family; Region: DHDPS-like; cd00408 443906002251 inhibitor site; inhibition site 443906002252 active site 443906002253 dimer interface [polypeptide binding]; other site 443906002254 catalytic residue [active] 443906002255 hydroxyproline-2-epimerase; Provisional; Region: PRK13971 443906002256 Proline racemase; Region: Pro_racemase; pfam05544 443906002257 NAD(P)+-dependent aldehyde dehydrogenase superfamily; Region: ALDH-SF; cl11961 443906002258 NAD(P) binding site [chemical binding]; other site 443906002259 catalytic residues [active] 443906002260 NAD-dependent aldehyde dehydrogenases [Energy production and conversion]; Region: PutA; COG1012 443906002261 acyl-coenzyme A oxidase; Region: PLN02636 443906002262 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 443906002263 active site 443906002264 PemK-like protein; Region: PemK; pfam02452 443906002265 Ribbon-helix-helix protein, copG family; Region: RHH_1; pfam01402 443906002266 SGNH_hydrolase subfamily, FeeA, FeeB and similar esterases/lipases. FeeA and FeeB are part of a biosynthetic gene cluster and may participate in the biosynthesis of long-chain N-acyltyrosines by providing saturated and unsaturated fatty acids, which it...; Region: FeeA_FeeB_like; cd01836 443906002267 active site 443906002268 catalytic triad [active] 443906002269 oxyanion hole [active] 443906002270 proline iminopeptidase, Neisseria-type subfamily; Region: pro_imino_pep_1; TIGR01249 443906002271 homoserine O-acetyltransferase; Provisional; Region: metX; cl17114 443906002272 Cytidylyltransferase; Region: CTP_transf_2; pfam01467 443906002273 nucleotidyl transferase superfamily; Region: nt_trans; cl00015 443906002274 active site 443906002275 nucleotide binding site [chemical binding]; other site 443906002276 HIGH motif; other site 443906002277 KMSKS motif; other site 443906002278 Right handed beta helix region; Region: Beta_helix; pfam13229 443906002279 putative pectinesterase; Region: PLN02432; cl01911 443906002280 Right handed beta helix region; Region: Beta_helix; pfam13229 443906002281 exopolysaccharide biosynthesis polyprenyl glycosylphosphotransferase; Region: EPS_sugtrans; TIGR03025 443906002282 Bacterial sugar transferase; Region: Bac_transf; pfam02397 443906002283 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 443906002284 This family is most closely related to the GT1 family of glycosyltransferases. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can...; Region: GT1_like_6; cd04955 443906002285 CDP-alcohol phosphatidyltransferase; Region: CDP-OH_P_transf; pfam01066 443906002286 This family is most closely related to the GT1 family of glycosyltransferases and named after YqgM in Bacillus licheniformis about which little is known. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to...; Region: GT1_YqgM_like; cd03801 443906002287 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 443906002288 Concanavalin A-like lectin/glucanases superfamily; Region: Laminin_G_3; pfam13385 443906002289 Laminin G domain; Laminin G-like domains are usually Ca++ mediated receptors that can have binding sites for steroids, beta1 integrins, heparin, sulfatides, fibulin-1, and alpha-dystroglycans. Proteins that contain LamG domains serve a variety of...; Region: LamG; cd00110 443906002290 polycystic kidney disease I (PKD) domain; similar to other cell-surface modules, with an IG-like fold; domain probably functions as a ligand binding site in protein-protein or protein-carbohydrate interactions; a single instance of the repeat is...; Region: PKD; cd00146 443906002291 polycystic kidney disease I (PKD) domain; similar to other cell-surface modules, with an IG-like fold; domain probably functions as a ligand binding site in protein-protein or protein-carbohydrate interactions; a single instance of the repeat is...; Region: PKD; cd00146 443906002292 FOG: PKD repeat [General function prediction only]; Region: COG3291 443906002293 polycystic kidney disease I (PKD) domain; similar to other cell-surface modules, with an IG-like fold; domain probably functions as a ligand binding site in protein-protein or protein-carbohydrate interactions; a single instance of the repeat is...; Region: PKD; cd00146 443906002294 Chain length determinant protein; Region: Wzz; cl15801 443906002295 capsular exopolysaccharide family; Region: eps_fam; TIGR01007 443906002296 ArsA ATPase functionas as an efflux pump located on the inner membrane of the cell. This ATP-driven oxyanion pump catalyzes the extrusion of arsenite, antimonite and arsenate. Maintenance of a low intracellular concentration of oxyanion produces...; Region: ArsA; cd02035 443906002297 Nucleotide binding site [chemical binding]; other site 443906002298 P loop; other site 443906002299 DTAP/Switch II; other site 443906002300 Switch I; other site 443906002301 Protein of unknown function (Hypoth_ymh); Region: Hypoth_Ymh; pfam09509 443906002302 Predicted glycosyltransferases [General function prediction only]; Region: COG1216 443906002303 Subfamily of Glycosyltransferase Family GT2 of unknown function; Region: GT_2_like_c; cd04186 443906002304 Probable Catalytic site; other site 443906002305 metal-binding site 443906002306 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 443906002307 Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013 443906002308 Uncharacterized subfamily of the multidrug and toxic compound extrusion (MATE) proteins; Region: MATE_tuaB_like; cd13127 443906002309 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 443906002310 Nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: WcaG; COG0451 443906002311 NAD(P) binding site [chemical binding]; other site 443906002312 active site 443906002313 MarR family; Region: MarR; pfam01047 443906002314 Uncharacterized conserved protein (COG2071); Region: DUF2071; pfam09844 443906002315 Glucoamylase and related glycosyl hydrolases [Carbohydrate transport and metabolism]; Region: SGA1; COG3387 443906002316 Glycosyl hydrolases family 15; Region: Glyco_hydro_15; pfam00723 443906002317 Macro domain, Appr-1"-pase_like family. The macro domain is a high-affinity ADP-ribose binding module found in a variety of proteins as a stand-alone domain or in combination with other domains like in histone macroH2A and some PARPs (poly...; Region: Macro_Appr_pase_like; cd02908 443906002318 putative ADP-ribose binding site [chemical binding]; other site 443906002319 putative active site [active] 443906002320 Membrane proteins related to metalloendopeptidases [Cell envelope biogenesis, outer membrane]; Region: NlpD; COG0739 443906002321 Peptidase family M23; Region: Peptidase_M23; pfam01551 443906002322 Cell wall-associated hydrolases (invasion-associated proteins) [Cell envelope biogenesis, outer membrane]; Region: Spr; COG0791 443906002323 NlpC/P60 family; Region: NLPC_P60; pfam00877 443906002324 Inorganic pyrophosphatase. These enzymes hydrolyze inorganic pyrophosphate (PPi) to two molecules of orthophosphates (Pi). The reaction requires bivalent cations. The enzymes in general exist as homooligomers; Region: pyrophosphatase; cd00412 443906002325 dimer interface [polypeptide binding]; other site 443906002326 substrate binding site [chemical binding]; other site 443906002327 metal binding sites [ion binding]; metal-binding site 443906002328 N-terminal domain of predicted ATPase of the PP-loop faimly implicated in cell cycle control [Cell division and chromosome partitioning]. This is a subfamily of Adenine nucleotide alpha hydrolases superfamily.Adeninosine nucleotide alpha hydrolases...; Region: PP-ATPase; cd01992 443906002329 tRNA(Ile)-lysidine synthase MesJ [Cell cycle control, cell division, chromosome partitioning]; Region: MesJ; COG0037 443906002330 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 443906002331 active site 443906002332 FtsH Extracellular; Region: FtsH_ext; pfam06480 443906002333 ATP-dependent metalloprotease FtsH; Region: FtsH_fam; TIGR01241 443906002334 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 443906002335 Walker A motif; other site 443906002336 ATP binding site [chemical binding]; other site 443906002337 Walker B motif; other site 443906002338 arginine finger; other site 443906002339 Peptidase family M41; Region: Peptidase_M41; pfam01434 443906002340 GTP cyclohydrolase I; Provisional; Region: PLN03044 443906002341 GTP cyclohydrolase I; Provisional; Region: folE; PRK09347 443906002342 active site 443906002343 Pterin binding enzymes. This family includes dihydropteroate synthase (DHPS) and cobalamin-dependent methyltransferases such as methyltetrahydrofolate, corrinoid iron-sulfur protein methyltransferase (MeTr) and methionine synthase (MetH). DHPS, a...; Region: Pterin_binding; cl00219 443906002344 dihydropteroate synthase; Region: DHPS; TIGR01496 443906002345 substrate binding pocket [chemical binding]; other site 443906002346 dimer interface [polypeptide binding]; other site 443906002347 inhibitor binding site; inhibition site 443906002348 Dihydroneopterin aldolase (DHNA) and 7,8-dihydroneopterin triphosphate epimerase domain (DHNTPE); these enzymes have been designated folB and folX, respectively. Folate derivatives are essential cofactors in the biosynthesis of purines, pyrimidines, and...; Region: DHNA_DHNTPE; cd00534 443906002349 homooctamer interface [polypeptide binding]; other site 443906002350 active site 443906002351 7,8-dihydro-6-hydroxymethylpterin-pyrophosphokinase (HPPK). Folate derivatives are essential cofactors in the biosynthesis of purines, pyrimidines, and amino acids as well as formyl-tRNA. Mammalian cells are able to utilize pre-formed folates after...; Region: HPPK; cd00483 443906002352 catalytic center binding site [active] 443906002353 ATP binding site [chemical binding]; other site 443906002354 Protein of unknown function (DUF3180); Region: DUF3180; pfam11377 443906002355 Bacterial PH domain; Region: DUF304; pfam03703 443906002356 Bacterial PH domain; Region: DUF304; pfam03703 443906002357 Bacterial PH domain; Region: DUF304; cl01348 443906002358 Bacterial PH domain; Region: DUF304; pfam03703 443906002359 Rossmann-like domain; Region: Rossmann-like; pfam10727 443906002360 Domain of unknown function (DUF2520); Region: DUF2520; pfam10728 443906002361 Pantoate-beta-alanine ligase; Region: PanC; cd00560 443906002362 pantoate--beta-alanine ligase; Region: panC; TIGR00018 443906002363 active site 443906002364 ATP-binding site [chemical binding]; other site 443906002365 pantoate-binding site; other site 443906002366 HXXH motif; other site 443906002367 lysyl-tRNA synthetase; Reviewed; Region: lysS; PRK00484 443906002368 LysRS_N: N-terminal, anticodon recognition domain of lysyl-tRNA synthetases (LysRS). These enzymes are homodimeric class 2b aminoacyl-tRNA synthetases (aaRSs). This domain is a beta-barrel domain (OB fold) involved in binding the tRNA anticodon stem-loop; Region: LysRS_N; cd04322 443906002369 dimer interface [polypeptide binding]; other site 443906002370 putative anticodon binding site; other site 443906002371 Class II tRNA amino-acyl synthetase-like catalytic core domain. Class II amino acyl-tRNA synthetases (aaRS) share a common fold and generally attach an amino acid to the 3' OH of ribose of the appropriate tRNA. PheRS is an exception in that it...; Region: class_II_aaRS-like_core; cl00268 443906002372 motif 1; other site 443906002373 dimer interface [polypeptide binding]; other site 443906002374 active site 443906002375 motif 2; other site 443906002376 motif 3; other site 443906002377 ATP-binding subunits of Clp protease and DnaK/DnaJ chaperones [Posttranslational modification, protein turnover, chaperones]; Region: clpA; COG0542 443906002378 Clp amino terminal domain; Region: Clp_N; pfam02861 443906002379 Clp amino terminal domain; Region: Clp_N; pfam02861 443906002380 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 443906002381 Walker A motif; other site 443906002382 ATP binding site [chemical binding]; other site 443906002383 Walker B motif; other site 443906002384 arginine finger; other site 443906002385 UvrB/uvrC motif; Region: UVR; pfam02151 443906002386 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 443906002387 Walker A motif; other site 443906002388 ATP binding site [chemical binding]; other site 443906002389 Walker B motif; other site 443906002390 C-terminal, D2-small domain, of ClpB protein; Region: ClpB_D2-small; pfam10431 443906002391 Nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: WcaG; COG0451 443906002392 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 443906002393 NAD(P) binding site [chemical binding]; other site 443906002394 active site 443906002395 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 443906002396 Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248 443906002397 active site 443906002398 catalytic tetrad [active] 443906002399 Ribosomal protein L10 family, L10 subfamily; composed of bacterial 50S ribosomal protein and eukaryotic mitochondrial 39S ribosomal protein, L10. L10 occupies the L7/L12 stalk of the ribosome. The N-terminal domain (NTD) of L10 interacts with L11 protein...; Region: Ribosomal_L10; cd05797 443906002400 23S rRNA interface [nucleotide binding]; other site 443906002401 Interface with L7/L12 ribosomal proteins [polypeptide binding]; other site 443906002402 Ribosomal protein L7/L12. Ribosomal protein L7/L12 refers to the large ribosomal subunit proteins L7 and L12, which are identical except that L7 is acetylated at the N terminus. It is a component of the L7/L12 stalk, which is located at the surface of...; Region: Ribosomal_L7_L12; cd00387 443906002403 core dimer interface [polypeptide binding]; other site 443906002404 peripheral dimer interface [polypeptide binding]; other site 443906002405 L10 interface [polypeptide binding]; other site 443906002406 L11 interface [polypeptide binding]; other site 443906002407 putative EF-Tu interaction site [polypeptide binding]; other site 443906002408 putative EF-G interaction site [polypeptide binding]; other site 443906002409 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 443906002410 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 443906002411 DNA binding residues [nucleotide binding] 443906002412 dimerization interface [polypeptide binding]; other site 443906002413 Winged helix DNA-binding domain; Region: HTH_27; pfam13463 443906002414 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 443906002415 putative substrate translocation pore; other site 443906002416 Transcriptional regulators [Transcription]; Region: PurR; COG1609 443906002417 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 443906002418 DNA binding site [nucleotide binding] 443906002419 domain linker motif; other site 443906002420 Ligand binding domain of the LacI tanscriptional regulator family belonging to the type I periplasmic-binding fold protein superfamily; Region: PBP1_LacI_sugar_binding_like; cd06267 443906002421 dimerization interface [polypeptide binding]; other site 443906002422 ligand binding site [chemical binding]; other site 443906002423 ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653 443906002424 ABC-type spermidine/putrescine transport system, permease component II [Amino acid transport and metabolism]; Region: PotC; COG1177 443906002425 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 443906002426 dimer interface [polypeptide binding]; other site 443906002427 conserved gate region; other site 443906002428 putative PBP binding loops; other site 443906002429 ABC-ATPase subunit interface; other site 443906002430 ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395 443906002431 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 443906002432 dimer interface [polypeptide binding]; other site 443906002433 conserved gate region; other site 443906002434 putative PBP binding loops; other site 443906002435 ABC-ATPase subunit interface; other site 443906002436 ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132 443906002437 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 443906002438 ATP-binding cassette domain of a mitochondrial protein MTABC3 and related proteins; Region: ABC_MTABC3_MDL1_MDL2; cd03249 443906002439 Walker A/P-loop; other site 443906002440 ATP binding site [chemical binding]; other site 443906002441 Q-loop/lid; other site 443906002442 ABC transporter signature motif; other site 443906002443 Walker B; other site 443906002444 D-loop; other site 443906002445 H-loop/switch region; other site 443906002446 Domain of unknown function (DUF305); Region: DUF305; pfam03713 443906002447 Protein of unknown function (DUF3105); Region: DUF3105; pfam11303 443906002448 cystathionine beta-synthase; Region: cysta_beta; TIGR01137 443906002449 CBS_like: This subgroup includes Cystathionine beta-synthase (CBS) and Cysteine synthase. CBS is a unique heme-containing enzyme that catalyzes a pyridoxal 5'-phosphate (PLP)-dependent condensation of serine and homocysteine to give cystathionine; Region: CBS_like; cd01561 443906002450 dimer interface [polypeptide binding]; other site 443906002451 pyridoxal 5'-phosphate binding site [chemical binding]; other site 443906002452 catalytic residue [active] 443906002453 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains associated with the pyridoxal-phosphate (PALP) dependent enzyme domain upstream. The vitamin B6 complex comprises pyridoxine, pyridoxal, and pyridoxamine, as well...; Region: CBS_pair_PALP_assoc2; cd04609 443906002454 cystathionine gamma-synthase; Provisional; Region: PRK07811 443906002455 CGS_like: Cystathionine gamma-synthase is a PLP dependent enzyme and catalyzes the committed step of methionine biosynthesis. This pathway is unique to microorganisms and plants, rendering the enzyme an attractive target for the development of...; Region: CGS_like; cd00614 443906002456 homodimer interface [polypeptide binding]; other site 443906002457 substrate-cofactor binding pocket; other site 443906002458 pyridoxal 5'-phosphate binding site [chemical binding]; other site 443906002459 catalytic residue [active] 443906002460 RNase HI family found mainly in prokaryotes; Region: RNase_HI_prokaryote_like; cd09278 443906002461 RNA/DNA hybrid binding site [nucleotide binding]; other site 443906002462 active site 443906002463 Ribbon-helix-helix protein, copG family; Region: RHH_1; pfam01402 443906002464 Transcriptional regulators [Transcription]; Region: PurR; COG1609 443906002465 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 443906002466 DNA binding site [nucleotide binding] 443906002467 domain linker motif; other site 443906002468 Ligand-binding domain of DNA transcription repressor LacI specific for lactose, a member of the LacI-GalR family of bacterial transcription regulators; Region: PBP1_LacI; cd01574 443906002469 ligand binding site [chemical binding]; other site 443906002470 dimerization interface (open form) [polypeptide binding]; other site 443906002471 dimerization interface (closed form) [polypeptide binding]; other site 443906002472 ribulokinase; Provisional; Region: PRK04123 443906002473 Ribulokinases; belongs to the FGGY family of carbohydrate kinases; Region: FGGY_RBK; cd07781 443906002474 N- and C-terminal domain interface [polypeptide binding]; other site 443906002475 active site 443906002476 MgATP binding site [chemical binding]; other site 443906002477 catalytic site [active] 443906002478 metal binding site [ion binding]; metal-binding site 443906002479 carbohydrate binding site [chemical binding]; other site 443906002480 homodimer interface [polypeptide binding]; other site 443906002481 L-ribulose-5-phosphate 4-epimerase; Validated; Region: PRK06557 443906002482 intersubunit interface [polypeptide binding]; other site 443906002483 active site 443906002484 Zn2+ binding site [ion binding]; other site 443906002485 L-arabinose isomerase; Provisional; Region: PRK02929 443906002486 L-fucose isomerase (FucIase) and L-arabinose isomerase (AI) family; composed of FucIase, AI and similar proteins. FucIase converts L-fucose, an aldohexose, to its ketose form, which prepares it for aldol cleavage (similar to the isomerization of glucose...; Region: L-fuc_L-ara-isomerases; cl00947 443906002487 hexamer (dimer of trimers) interface [polypeptide binding]; other site 443906002488 trimer interface [polypeptide binding]; other site 443906002489 substrate binding site [chemical binding]; other site 443906002490 Mn binding site [ion binding]; other site 443906002491 ABC-type xylose transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: XylF; COG4213 443906002492 Periplasmic xylose-binding component of the ABC-type transport systems that belong to a family of pentose/hexose sugar-binding proteins of the type I periplasmic binding protein (PBP1) superfamily; Region: PBP1_ABC_xylose_binding; cd01538 443906002493 putative ligand binding site [chemical binding]; other site 443906002494 xylose transporter ATP-binding subunit; Provisional; Region: PRK13549 443906002495 First domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_I; cd03216 443906002496 Walker A/P-loop; other site 443906002497 ATP binding site [chemical binding]; other site 443906002498 Q-loop/lid; other site 443906002499 ABC transporter signature motif; other site 443906002500 Walker B; other site 443906002501 D-loop; other site 443906002502 H-loop/switch region; other site 443906002503 Second domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_II; cd03215 443906002504 Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653 443906002505 Transmembrane subunit (TM) of Escherichia coli AraH and related proteins. E. coli AraH is the TM of a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of the monosaccharide arabinose. This group...; Region: TM_PBP1_transp_AraH_like; cd06579 443906002506 Transmembrane subunit (TM) of Escherichia coli AraH and related proteins. E. coli AraH is the TM of a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of the monosaccharide arabinose. This group...; Region: TM_PBP1_transp_AraH_like; cd06579 443906002507 Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653 443906002508 TM-ABC transporter signature motif; other site 443906002509 xylose isomerase, Arthrobacter type; Region: xylA_Arthro; TIGR02631 443906002510 xylose isomerase; Provisional; Region: PRK12677 443906002511 Glycosyl hydrolase family 1; Region: Glyco_hydro_1; cl01046 443906002512 beta-galactosidase; Region: BGL; TIGR03356 443906002513 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl17182 443906002514 Acetyltransferase (GNAT) domain; Region: Acetyltransf_3; pfam13302 443906002515 MarR family; Region: MarR_2; cl17246 443906002516 helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347 443906002517 Transcriptional regulator [Transcription]; Region: LysR; COG0583 443906002518 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 443906002519 The C-terminal substrate binding domain of an uncharacterized LysR-type transcriptional regulator, contains the type 2 periplasmic binding fold; Region: PBP2_LTTR_like_6; cd08423 443906002520 putative dimerization interface [polypeptide binding]; other site 443906002521 Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321 443906002522 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 443906002523 catalytic residue [active] 443906002524 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 443906002525 bicyclomycin/multidrug efflux system; Provisional; Region: PRK11102 443906002526 putative substrate translocation pore; other site 443906002527 Aminoglycoside/hydroxyurea antibiotic resistance kinase; Region: APH_6_hur; cl17810 443906002528 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 443906002529 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 443906002530 DNA binding residues [nucleotide binding] 443906002531 dimerization interface [polypeptide binding]; other site 443906002532 atypical (a) SDRs, subgroup 5; Region: SDR_a5; cd05243 443906002533 NADH(P)-binding; Region: NAD_binding_10; pfam13460 443906002534 NAD(P) binding site [chemical binding]; other site 443906002535 putative active site [active] 443906002536 phosphate acetyltransferase; Reviewed; Region: PRK05632 443906002537 The Fer4_NifH superfamily contains a variety of proteins which share a common ATP-binding domain. Functionally, proteins in this superfamily use the energy from hydrolysis of NTP to transfer electron or ion; Region: Fer4_NifH; cl17203 443906002538 DRTGG domain; Region: DRTGG; pfam07085 443906002539 phosphotransacetylase; Reviewed; Region: eutD; PRK09653 443906002540 propionate/acetate kinase; Provisional; Region: PRK12379 443906002541 acetate kinase A/propionate kinase 2; Reviewed; Region: PRK00180 443906002542 Peptidase S46; Region: Peptidase_S46; pfam10459 443906002543 Horizontally Transferred TransMembrane Domain; Region: HTTM; smart00752 443906002544 DNA polymerase III, subunit gamma and tau; Region: dnaX_nterm; TIGR02397 443906002545 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 443906002546 Walker A motif; other site 443906002547 ATP binding site [chemical binding]; other site 443906002548 Walker B motif; other site 443906002549 arginine finger; other site 443906002550 DNA polymerase III subunits gamma and tau domain III; Region: DNA_pol3_gamma3; pfam12169 443906002551 recombination protein RecR; Reviewed; Region: recR; PRK00076 443906002552 endonuclease III; includes endonuclease III (DNA-(apurinic or apyrimidinic site) lyase), alkylbase DNA glycosidases (Alka-family) and other DNA glycosidases; Region: ENDO3c; cl14786 443906002553 RecR protein; Region: RecR; pfam02132 443906002554 TOPRIM_recR: topoisomerase-primase (TOPRIM) nucleotidyl transferase/hydrolase domain of the type found in Escherichia coli RecR. RecR participates in the RecFOR pathway of homologous recombinational repair in prokaryotes. This pathway provides a...; Region: TOPRIM_recR; cd01025 443906002555 putative active site [active] 443906002556 putative metal-binding site [ion binding]; other site 443906002557 tetramer interface [polypeptide binding]; other site 443906002558 aspartate kinase; Reviewed; Region: PRK06635 443906002559 AAK_AKii-LysC-BS: Amino Acid Kinase Superfamily (AAK), AKii; this CD includes the N-terminal catalytic aspartokinase (AK) domain of the lysine-sensitive aspartokinase isoenzyme AKII of Bacillus subtilis 168, and the lysine plus threonine-sensitive...; Region: AAK_AKii-LysC-BS; cd04261 443906002560 putative nucleotide binding site [chemical binding]; other site 443906002561 putative catalytic residues [active] 443906002562 putative Mg ion binding site [ion binding]; other site 443906002563 putative aspartate binding site [chemical binding]; other site 443906002564 ACT domains of the lysine-sensitive aspartokinase isoenzyme AKII of Bacillus subtilis (BS) strain 168 and related proteins; Region: ACT_AKii-LysC-BS-like_1; cd04913 443906002565 putative allosteric regulatory site; other site 443906002566 ACT domains of the lysine-sensitive, aspartokinase (AK) isoenzyme AKII of Bacillus subtilis (BS) strain 168 and related domains; Region: ACT_AKii-LysC-BS-like_2; cd04936 443906002567 putative allosteric regulatory residue; other site 443906002568 aspartate-semialdehyde dehydrogenase; Provisional; Region: PRK14874 443906002569 Semialdehyde dehydrogenase, NAD binding domain; Region: Semialdhyde_dh; smart00859 443906002570 malate:quinone oxidoreductase; Validated; Region: PRK05257 443906002571 malate:quinone-oxidoreductase; Region: mal_quin_oxido; TIGR01320 443906002572 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 443906002573 Radical SAM superfamily; Region: Radical_SAM; pfam04055 443906002574 FeS/SAM binding site; other site 443906002575 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cl17315 443906002576 DNA binding residues [nucleotide binding] 443906002577 dimerization interface [polypeptide binding]; other site 443906002578 thymidine kinase; Provisional; Region: PRK04296 443906002579 TIGR04140 family protein; Region: chp_AF_0576 443906002580 Chain length determinant protein; Region: Wzz; cl15801 443906002581 capsular exopolysaccharide family; Region: eps_fam; TIGR01007 443906002582 The Fer4_NifH superfamily contains a variety of proteins which share a common ATP-binding domain. Functionally, proteins in this superfamily use the energy from hydrolysis of NTP to transfer electron or ion; Region: Fer4_NifH; cl17203 443906002583 Protein of unknown function (DUF4012); Region: DUF4012; pfam13196 443906002584 luciferase family oxidoreductase, group 1; Region: oxido_grp_1; TIGR03558 443906002585 probable oxidoreductase, LLM family; Region: LLM_2I7G; TIGR03858 443906002586 Flavin-utilizing monoxygenases; Region: Flavin_utilizing_monoxygenases; cd00347 443906002587 Transglycosylase; Region: Transgly; pfam00912 443906002588 penicillin-binding protein, 1A family; Region: PBP_1a_fam; TIGR02074 443906002589 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; cl17760 443906002590 Predicted acyltransferases [Lipid metabolism]; Region: COG1835 443906002591 Bacillus subtilis YkuE and related proteins, C-terminal metallophosphatase domain; Region: MPP_YkuE_C; cd07385 443906002592 Calcineurin-like phosphoesterase; Region: Metallophos; pfam00149 443906002593 putative active site [active] 443906002594 putative metal binding site [ion binding]; other site 443906002595 Transglycosylase; Region: Transgly; pfam00912 443906002596 penicillin-binding protein, 1A family; Region: PBP_1a_fam; TIGR02074 443906002597 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; cl17760 443906002598 PASTA domain of bacterial serine/threonine kinase pknB-like proteins. PknB is a member of a group of related transmembrane sensor kinases present in many gram positive bacteria, which has been shown to regulate cell shape in Mycobacterium tubercolosis; Region: PASTA_pknB; cd06577 443906002599 PASTA domain of bacterial serine/threonine kinase pknB-like proteins. PknB is a member of a group of related transmembrane sensor kinases present in many gram positive bacteria, which has been shown to regulate cell shape in Mycobacterium tubercolosis; Region: PASTA_pknB; cd06577 443906002600 Domain of unknown function (DUF4177); Region: DUF4177; pfam13783 443906002601 This group of proteins belong to a large family of YjgF/YER057c/UK114-like proteins present in bacteria, archaea, and eukaryotes with no definitive function. The conserved domain is similar in structure to chorismate mutase but there is no sequence...; Region: YjgF_YER057c_UK114_like_1; cd02199 443906002602 homotrimer interaction site [polypeptide binding]; other site 443906002603 putative active site [active] 443906002604 acetyl-CoA synthetase; Provisional; Region: PRK00174 443906002605 Acetyl-CoA synthetase (also known as acetate-CoA ligase and acetyl-activating enzyme); Region: ACS; cd05966 443906002606 active site 443906002607 CoA binding site [chemical binding]; other site 443906002608 acyl-activating enzyme (AAE) consensus motif; other site 443906002609 AMP binding site [chemical binding]; other site 443906002610 acetate binding site [chemical binding]; other site 443906002611 Type II/IV secretion system protein; Region: T2SE; pfam00437 443906002612 Type IV secretory pathway component VirB11, and related ATPases. The homohexamer, VirB11 is one of eleven Vir proteins, which are required for T-pilus biogenesis and virulence in the transfer of T-DNA from the Ti (tumor-inducing) plasmid of bacterial to...; Region: VirB11-like_ATPase; cd01130 443906002613 ATP binding site [chemical binding]; other site 443906002614 Walker A motif; other site 443906002615 hexamer interface [polypeptide binding]; other site 443906002616 Walker B motif; other site 443906002617 Protein of unknown function (DUF4244); Region: DUF4244; pfam14029 443906002618 DNA topoisomerase I subunit omega; Validated; Region: PRK07561 443906002619 TOPRIM_TopoIA_TopoI: The topoisomerase-primase (TORPIM) domain found in members of the type IA family of DNA topoisomerases (Topo IA) similar to Escherichia coli DNA topoisomerase I. Type IA DNA topoisomerases remove (relax) negative supercoils in the...; Region: TOPRIM_TopoIA_TopoI; cd03363 443906002620 active site 443906002621 interdomain interaction site; other site 443906002622 putative metal-binding site [ion binding]; other site 443906002623 nucleotide binding site [chemical binding]; other site 443906002624 DNA Topoisomerase, subtype IA; DNA-binding, ATP-binding and catalytic domain of bacterial DNA topoisomerases I and III, and eukaryotic DNA topoisomerase III and eubacterial and archael reverse gyrases. Topoisomerases clevage single or double stranded DNA...; Region: TOP1Ac; cd00186 443906002625 domain I; other site 443906002626 DNA binding groove [nucleotide binding] 443906002627 phosphate binding site [ion binding]; other site 443906002628 domain II; other site 443906002629 domain III; other site 443906002630 nucleotide binding site [chemical binding]; other site 443906002631 catalytic site [active] 443906002632 domain IV; other site 443906002633 Topoisomerase C-terminal repeat; Region: Toprim_C_rpt; pfam13368 443906002634 Topoisomerase C-terminal repeat; Region: Toprim_C_rpt; pfam13368 443906002635 Topoisomerase C-terminal repeat; Region: Toprim_C_rpt; pfam13368 443906002636 thymidylate kinase; Region: DTMP_kinase; TIGR00041 443906002637 Thymidine monophosphate kinase (TMPK), also known as thymidylate kinase, catalyzes the phosphorylation of thymidine monophosphate (TMP) to thymidine diphosphate (TDP) utilizing ATP as its preferred phophoryl donor. TMPK represents the rate-limiting step...; Region: TMPK; cd01672 443906002638 TMP-binding site; other site 443906002639 ATP-binding site [chemical binding]; other site 443906002640 DNA polymerase III subunit delta'; Validated; Region: PRK07940 443906002641 DNA polymerase III subunit delta'; Validated; Region: PRK08485 443906002642 Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596 443906002643 alpha/beta hydrolase fold; Region: Abhydrolase_1; pfam00561 443906002644 TAP-like protein; Region: Abhydrolase_4; pfam08386 443906002645 D-Ala-D-Ala carboxypeptidase 3 (S13) family; Region: Peptidase_S13; cl17429 443906002646 D-alanyl-D-alanine carboxypeptidase, serine-type, PBP4 family; Region: PBP4; TIGR00666 443906002647 Cysteine hydrolases; This family contains amidohydrolases, like CSHase (N-carbamoylsarcosine amidohydrolase), involved in creatine metabolism and nicotinamidase, converting nicotinamide to nicotinic acid and ammonia in the pyridine nucleotide cycle. It...; Region: cysteine_hydrolases; cl00220 443906002648 catalytic triad [active] 443906002649 conserved cis-peptide bond; other site 443906002650 succinic semialdehyde dehydrogenase; Region: PLN02278 443906002651 Mitochondrial succinate-semialdehyde dehydrogenase and ALDH family members 5A1 and 5F1-like; Region: ALDH_F5_SSADH_GabD; cd07103 443906002652 tetramerization interface [polypeptide binding]; other site 443906002653 NAD(P) binding site [chemical binding]; other site 443906002654 catalytic residues [active] 443906002655 rRNA methylases [Translation, ribosomal structure and biogenesis]; Region: SpoU; COG0566 443906002656 SpoU rRNA Methylase family; Region: SpoU_methylase; pfam00588 443906002657 Protein of unknown function (DUF2834); Region: DUF2834; pfam11196 443906002658 Protein of unknown function (DUF2834); Region: DUF2834; pfam11196 443906002659 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 443906002660 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 443906002661 Walker A/P-loop; other site 443906002662 ATP binding site [chemical binding]; other site 443906002663 ABC transporter; Region: ABC_tran; pfam00005 443906002664 Q-loop/lid; other site 443906002665 ABC transporter signature motif; other site 443906002666 Walker B; other site 443906002667 D-loop; other site 443906002668 H-loop/switch region; other site 443906002669 nodulation ABC transporter NodI; Provisional; Region: PRK13537 443906002670 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 443906002671 Walker A/P-loop; other site 443906002672 ATP binding site [chemical binding]; other site 443906002673 Q-loop/lid; other site 443906002674 ABC transporter signature motif; other site 443906002675 Walker B; other site 443906002676 D-loop; other site 443906002677 H-loop/switch region; other site 443906002678 ABC-type multidrug transport system, permease component [Defense mechanisms]; Region: COG0842 443906002679 ABC-2 type transporter; Region: ABC2_membrane; cl17235 443906002680 ABC-2 type transporter; Region: ABC2_membrane; cl17235 443906002681 ABC-type multidrug transport system, permease component [Defense mechanisms]; Region: COG0842 443906002682 Sugar kinases, ribokinase family [Carbohydrate transport and metabolism]; Region: RbsK; COG0524 443906002683 ribokinase/pfkB superfamily: Kinases that accept a wide variety of substrates, including carbohydrates and aromatic small molecules, all are phosphorylated at a hydroxyl group. The superfamily includes ribokinase, fructokinase, ketohexokinase; Region: ribokinase_pfkB_like; cl00192 443906002684 substrate binding site [chemical binding]; other site 443906002685 ATP binding site [chemical binding]; other site 443906002686 ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653 443906002687 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; pfam01547 443906002688 ABC-type sugar transport systems, permease components [Carbohydrate transport and metabolism]; Region: UgpA; COG1175 443906002689 ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395 443906002690 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 443906002691 dimer interface [polypeptide binding]; other site 443906002692 conserved gate region; other site 443906002693 putative PBP binding loops; other site 443906002694 ABC-ATPase subunit interface; other site 443906002695 Beta-glucosidase-related glycosidases [Carbohydrate transport and metabolism]; Region: BglX; COG1472 443906002696 Glycosyl hydrolase family 3 N terminal domain; Region: Glyco_hydro_3; cl07971 443906002697 DNA-binding transcriptional repressor EbgR; Provisional; Region: PRK10339 443906002698 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 443906002699 DNA binding site [nucleotide binding] 443906002700 domain linker motif; other site 443906002701 Ligand binding domain of the LacI tanscriptional regulator family belonging to the type I periplasmic-binding fold protein superfamily; Region: PBP1_LacI_sugar_binding_like; cd06267 443906002702 dimerization interface [polypeptide binding]; other site 443906002703 ligand binding site [chemical binding]; other site 443906002704 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2258 443906002705 MOSC domain; Region: MOSC; pfam03473 443906002706 metabolite-proton symporter; Region: 2A0106; TIGR00883 443906002707 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 443906002708 putative substrate translocation pore; other site 443906002709 metabolite-proton symporter; Region: 2A0106; TIGR00883 443906002710 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cl17904 443906002711 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 443906002712 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppB; COG0601 443906002713 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppC; COG1173 443906002714 The substrate-binding domain of an ABC-type nickel/oligopeptide-like import system contains the type 2 periplasmic binding fold; Region: PBP2_NikA_DppA_OppA_like; cl01709 443906002715 Bacterial extracellular solute-binding proteins, family 5 Middle; Region: SBP_bac_5; pfam00496 443906002716 multidrug resistance protein MdtH; Provisional; Region: PRK11646 443906002717 ABC-type dipeptide/oligopeptide/nickel transport system, ATPase component [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppF; COG1124 443906002718 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 443906002719 Walker A/P-loop; other site 443906002720 ATP binding site [chemical binding]; other site 443906002721 Q-loop/lid; other site 443906002722 ABC transporter signature motif; other site 443906002723 Walker B; other site 443906002724 D-loop; other site 443906002725 H-loop/switch region; other site 443906002726 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097 443906002727 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 443906002728 nickel import ATP-binding protein NikD; Region: nickel_nikD; TIGR02770 443906002729 Walker A/P-loop; other site 443906002730 ATP binding site [chemical binding]; other site 443906002731 Q-loop/lid; other site 443906002732 ABC transporter signature motif; other site 443906002733 Walker B; other site 443906002734 D-loop; other site 443906002735 H-loop/switch region; other site 443906002736 lumazine synthase (6,7-dimethyl-8-ribityllumazine synthase, LS), catalyzes the penultimate step in the biosynthesis of riboflavin (vitamin B2); type-I; Region: Lumazine_synthase-I; cd09209 443906002737 homopentamer interface [polypeptide binding]; other site 443906002738 active site 443906002739 bifunctional 3,4-dihydroxy-2-butanone 4-phosphate synthase/GTP cyclohydrolase II protein; Provisional; Region: PRK09311 443906002740 3,4-dihydroxy-2-butanone 4-phosphate synthase; Region: DHBP_synthase; pfam00926 443906002741 GTP cyclohydrolase II (RibA). GTP cyclohydrolase II catalyzes the conversion of GTP to 2,5-diamino-6-ribosylamino-4(3H)-pyrimidinone 5' phosphate, formate, pyrophosphate (APy), and GMP in the biosynthetic pathway of riboflavin. Riboflavin is the...; Region: GTP_cyclohydro2; cd00641 443906002742 dimerization interface [polypeptide binding]; other site 443906002743 active site 443906002744 riboflavin synthase subunit alpha; Provisional; Region: PRK09289 443906002745 Lumazine binding domain; Region: Lum_binding; pfam00677 443906002746 Lumazine binding domain; Region: Lum_binding; pfam00677 443906002747 riboflavin biosynthesis protein RibD; Region: eubact_ribD; TIGR00326 443906002748 Riboflavin-specific deaminase. Riboflavin biosynthesis protein RibD (Diaminohydroxyphosphoribosylaminopyrimidine deaminase) catalyzes the deamination of 2,5-diamino-6-ribosylamino-4(3H)-pyrimidinone 5'-phosphate, which is an intermediate step in the...; Region: Riboflavin_deaminase-reductase; cd01284 443906002749 catalytic motif [active] 443906002750 Zn binding site [ion binding]; other site 443906002751 RibD C-terminal domain; Region: RibD_C; cl17279 443906002752 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 443906002753 motif II; other site 443906002754 tryptophanyl-tRNA synthetase II; Reviewed; Region: PRK12282 443906002755 catalytic core domain of tryptophanyl-tRNA synthetase; Region: TrpRS_core; cd00806 443906002756 active site 443906002757 HIGH motif; other site 443906002758 dimer interface [polypeptide binding]; other site 443906002759 KMSKS motif; other site 443906002760 Neisseria meningitides Nape-like subfamily of the ExoIII family purinic/apyrimidinic (AP) endonucleases; Region: Nape_like_AP-endo; cd10281 443906002761 putative active site [active] 443906002762 putative catalytic site [active] 443906002763 putative DNA binding site [nucleotide binding]; other site 443906002764 putative phosphate binding site [ion binding]; other site 443906002765 metal binding site A [ion binding]; metal-binding site 443906002766 putative AP binding site [nucleotide binding]; other site 443906002767 putative metal binding site B [ion binding]; other site 443906002768 Virulence factor BrkB; Region: Virul_fac_BrkB; cl07918 443906002769 Phosphoenolpyruvate-protein kinase (PTS system EI component in bacteria) [Carbohydrate transport and metabolism]; Region: PtsA; COG1080 443906002770 PEP-utilising enzyme, N-terminal; Region: PEP-utilisers_N; pfam05524 443906002771 PEP-utilising enzyme, mobile domain; Region: PEP-utilizers; pfam00391 443906002772 PEP-utilising enzyme, TIM barrel domain; Region: PEP-utilizers_C; pfam02896 443906002773 succinate dehydrogenase iron-sulfur subunit; Reviewed; Region: sdhB; PRK05950 443906002774 2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207 443906002775 catalytic loop [active] 443906002776 iron binding site [ion binding]; other site 443906002777 succinate dehydrogenase flavoprotein subunit; Reviewed; Region: sdhA; PRK08205 443906002778 L-aspartate oxidase; Provisional; Region: PRK06175 443906002779 Fumarate reductase flavoprotein C-term; Region: Succ_DH_flav_C; pfam02910 443906002780 Succinate:quinone oxidoreductase (SQR) Type A subfamily, Succinate dehydrogenase D (SdhD)-like subunit; SQR catalyzes the oxidation of succinate to fumarate coupled to the reduction of quinone to quinol. Members of this subfamily reduce low potential...; Region: SQR_TypeA_SdhD_like; cd03500 443906002781 putative Iron-sulfur protein interface [polypeptide binding]; other site 443906002782 putative proximal heme binding site [chemical binding]; other site 443906002783 putative SdhC-like subunit interface [polypeptide binding]; other site 443906002784 putative distal heme binding site [chemical binding]; other site 443906002785 Succinate:quinone oxidoreductase (SQR) Type A subfamily, Succinate dehydrogenase C (SdhC)-like subunit; SQR catalyzes the oxidation of succinate to fumarate coupled to the reduction of quinone to quinol. Members of this subfamily reduce low potential...; Region: SQR_TypeA_SdhC_like; cd03501 443906002786 putative Iron-sulfur protein interface [polypeptide binding]; other site 443906002787 putative proximal heme binding site [chemical binding]; other site 443906002788 putative SdhD-like interface [polypeptide binding]; other site 443906002789 putative distal heme binding site [chemical binding]; other site 443906002790 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 443906002791 This family is most closely related to the GT1 family of glycosyltransferases. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can...; Region: GT1_like_2; cd03814 443906002792 Mannose-1-phosphate guanylyltransferase [Cell envelope biogenesis, outer membrane]; Region: {ManC}; COG0836 443906002793 GDP-M1P_Guanylyltransferase catalyzes the formation of GDP-Mannose; Region: GDP-M1P_Guanylyltransferase; cd02509 443906002794 Substrate binding site; other site 443906002795 Cupin domain; Region: Cupin_2; cl17218 443906002796 Uncharacterized ABC-type transport system, periplasmic component/surface lipoprotein [General function prediction only]; Region: Med; COG1744 443906002797 Periplasmic binding domain of basic membrane lipoprotein, PnrA, in Treponema pallidum and its homologs from other bacteria and Archaea; Region: PBP1_BmpA_PnrA_like; cd06354 443906002798 ligand binding site [chemical binding]; other site 443906002799 Uncharacterized ABC-type transport system, periplasmic component/surface lipoprotein [General function prediction only]; Region: Med; COG1744 443906002800 Periplasmic binding domain of basic membrane lipoprotein, PnrA, in Treponema pallidum and its homologs from other bacteria and Archaea; Region: PBP1_BmpA_PnrA_like; cd06354 443906002801 ligand binding site [chemical binding]; other site 443906002802 ABC-type uncharacterized transport systems, ATPase components [General function prediction only]; Region: COG3845 443906002803 First domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_I; cd03216 443906002804 Walker A/P-loop; other site 443906002805 ATP binding site [chemical binding]; other site 443906002806 Q-loop/lid; other site 443906002807 ABC transporter signature motif; other site 443906002808 Walker B; other site 443906002809 D-loop; other site 443906002810 H-loop/switch region; other site 443906002811 Second domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_II; cd03215 443906002812 Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653 443906002813 Transmembrane subunit (TM) of Treponema pallidum (Tp) RbsC-1, RbsC-2 and related proteins. This is a functionally uncharacterized subgroup of TMs which belong to a larger group of TMs of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette; Region: TM_PBP1_transp_TpRbsC_like; cd06580 443906002814 TM-ABC transporter signature motif; other site 443906002815 Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653 443906002816 Transmembrane subunit (TM) of Treponema pallidum (Tp) RbsC-1, RbsC-2 and related proteins. This is a functionally uncharacterized subgroup of TMs which belong to a larger group of TMs of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette; Region: TM_PBP1_transp_TpRbsC_like; cd06580 443906002817 TM-ABC transporter signature motif; other site 443906002818 Cytidine deaminase zinc-binding domain. These enzymes are Zn dependent. The zinc ion in the active site plays a central role in the proposed catalytic mechanism, activating a water molecule to form a hydroxide ion that performs a nucleophilic attack on...; Region: cytidine_deaminase; cd01283 443906002819 active site 443906002820 catalytic motif [active] 443906002821 Zn binding site [ion binding]; other site 443906002822 thymidine phosphorylase; Reviewed; Region: deoA; PRK05820 443906002823 Glycosyl transferase family, helical bundle domain; Region: Glycos_trans_3N; pfam02885 443906002824 Glycosyl transferase family, a/b domain; Region: Glycos_transf_3; pfam00591 443906002825 Pyrimidine nucleoside phosphorylase C-terminal domain; Region: PYNP_C; smart00941 443906002826 nuc_hydro_IU_UC_XIUA: inosine-uridine preferring, xanthosine-inosine-uridine-adenosine-preferring and, uridine-cytidine preferring nucleoside hydrolases. Nucleoside hydrolases cleave the N-glycosidic bond in nucleosides generating ribose and the...; Region: nuc_hydro_IU_UC_XIUA; cd02651 443906002827 active site 443906002828 tetramer interface [polypeptide binding]; other site 443906002829 adenosine deaminase; Provisional; Region: PRK09358 443906002830 Adenosine deaminase [Nucleotide transport and metabolism]; Region: Add; COG1816 443906002831 active site 443906002832 PTS_IIA, PTS system, fructose/mannitol specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_fru; cd00211 443906002833 active site 443906002834 phosphorylation site [posttranslational modification] 443906002835 PTS_IIB_ascorbate: subunit IIB of enzyme II (EII) of the L-ascorbate-specific phosphoenolpyruvate:carbohydrate phosphotransferase system (PTS). In this system, EII is an L-ascorbate-specific permease with two cytoplasmic subunits (IIA and IIB) and a...; Region: PTS_IIB_ascorbate; cd05563 443906002836 active site 443906002837 P-loop; other site 443906002838 phosphorylation site [posttranslational modification] 443906002839 Helix-Turn-Helix DNA binding domain of transcription regulators from the MerR superfamily; Region: HTH_MerR-SF; cl02600 443906002840 MerR HTH family regulatory protein; Region: MerR_1; pfam13411 443906002841 DNA binding residues [nucleotide binding] 443906002842 phosphoglucomutase-2-like protein; Provisional; Region: PTZ00150 443906002843 This CD includes PGM2 (phosphoglucomutase 2) and PGM2L1 (phosphoglucomutase 2-like 1). The mammalian PGM2 is thought to be a phosphopentomutase that catalyzes the conversion of the nucleoside breakdown products, ribose-1-phosphate and...; Region: PGM2; cd05799 443906002844 active site 443906002845 substrate binding site [chemical binding]; other site 443906002846 metal binding site [ion binding]; metal-binding site 443906002847 purine nucleoside phosphorylase; Provisional; Region: PRK08202 443906002848 flavoprotein disulfide reductase; Reviewed; Region: PRK07845 443906002849 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500 443906002850 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 443906002851 Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain; Region: Pyr_redox_dim; pfam02852 443906002852 acetyl-CoA carboxylase biotin carboxylase subunit; Validated; Region: PRK08591 443906002853 Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289 443906002854 Carbamoyl-phosphate synthase L chain, ATP binding domain; Region: CPSase_L_D2; pfam02786 443906002855 Biotin carboxylase C-terminal domain; Region: Biotin_carb_C; smart00878 443906002856 The biotinyl-domain or biotin carboxyl carrier protein (BCCP) domain is present in all biotin-dependent enzymes, such as acetyl-CoA carboxylase, pyruvate carboxylase, propionyl-CoA carboxylase, methylcrotonyl-CoA carboxylase, geranyl-CoA carboxylase; Region: biotinyl_domain; cd06850 443906002857 carboxyltransferase (CT) interaction site; other site 443906002858 biotinylation site [posttranslational modification]; other site 443906002859 Maf-like protein; Region: Maf; pfam02545 443906002860 Nucleotide binding protein Maf. Maf has been implicated in inhibition of septum formation in eukaryotes, bacteria and archaea, but homologs in B.subtilis and S.cerevisiae are nonessential for cell division. Maf has been predicted to be a nucleotide- or...; Region: Maf; cd00555 443906002861 active site 443906002862 dimer interface [polypeptide binding]; other site 443906002863 TRAM domain; Region: TRAM; pfam01938 443906002864 SAM-dependent methyltransferases related to tRNA (uracil-5-)-methyltransferase [Translation, ribosomal structure and biogenesis]; Region: TrmA; COG2265 443906002865 transcriptional regulator NarP; Provisional; Region: PRK10403 443906002866 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 443906002867 active site 443906002868 phosphorylation site [posttranslational modification] 443906002869 intermolecular recognition site; other site 443906002870 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 443906002871 DNA binding residues [nucleotide binding] 443906002872 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: COG4585 443906002873 Acetyl-CoA carboxylase, carboxyltransferase component (subunits alpha and beta) [Lipid metabolism]; Region: COG4799 443906002874 malonate decarboxylase subunit beta; Reviewed; Region: PRK07189; cl17682 443906002875 Acetyl-CoA carboxylase alpha subunit [Lipid metabolism]; Region: AccA; cl17345 443906002876 Biotin-(acetyl-CoA carboxylase) ligase [Coenzyme metabolism]; Region: BirA; COG0340 443906002877 Biotin/lipoate A/B protein ligase family; Region: BPL_LplA_LipB; pfam03099 443906002878 Biotin protein ligase C terminal domain; Region: BPL_C; pfam02237 443906002879 Bacterial PH domain; Region: DUF304; pfam03703 443906002880 Predicted membrane protein [Function unknown]; Region: COG2246 443906002881 GtrA-like protein; Region: GtrA; pfam04138 443906002882 phosphoribosylaminoimidazole carboxylase ATPase subunit; Reviewed; Region: PRK06019 443906002883 ATP-grasp domain; Region: ATP-grasp; pfam02222 443906002884 AIR carboxylase; Region: AIRC; pfam00731 443906002885 Transcriptional regulator [Transcription]; Region: LytR; COG1316 443906002886 This family is most closely related to the GT1 family of glycosyltransferases. mtfB (mannosyltransferase B) in E. coli has been shown to direct the growth of the O9-specific polysaccharide chain. It transfers two mannoses into the position 3 of the...; Region: GT1_mtfB_like; cd03809 443906002887 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 443906002888 ABC-type polysaccharide/polyol phosphate transport system, ATPase component [Carbohydrate transport and metabolism / Cell envelope biogenesis, outer membrane]; Region: TagH; COG1134 443906002889 ATP-binding cassette component of polysaccharide transport system; Region: ABC_KpsT_Wzt; cd03220 443906002890 Walker A/P-loop; other site 443906002891 ATP binding site [chemical binding]; other site 443906002892 Q-loop/lid; other site 443906002893 ABC transporter signature motif; other site 443906002894 Walker B; other site 443906002895 D-loop; other site 443906002896 H-loop/switch region; other site 443906002897 ABC-2 type transporter; Region: ABC2_membrane; pfam01061 443906002898 dTDP-6-deoxy-L-lyxo-4-hexulose reductase and related proteins, extended (e) SDRs; Region: dTDP_HR_like_SDR_e; cd05254 443906002899 RmlD substrate binding domain; Region: RmlD_sub_bind; pfam04321 443906002900 NADP binding site [chemical binding]; other site 443906002901 active site 443906002902 putative substrate binding site [chemical binding]; other site 443906002903 dTDP-D-glucose 4,6-dehydratase [Cell envelope biogenesis, outer membrane]; Region: RfbB; COG1088 443906002904 dTDP-D-glucose 4,6-dehydratase, extended (e) SDRs; Region: dTDP_GD_SDR_e; cd05246 443906002905 NAD binding site [chemical binding]; other site 443906002906 substrate binding site [chemical binding]; other site 443906002907 homodimer interface [polypeptide binding]; other site 443906002908 active site 443906002909 GtrA-like protein; Region: GtrA; pfam04138 443906002910 dTDP-4-dehydrorhamnose 3,5-epimerase; Region: dTDP_sugar_isom; cl17405 443906002911 G1P_TT_short is the short form of glucose-1-phosphate thymidylyltransferase; Region: G1P_TT_short; cd02538 443906002912 glucose-1-phosphate thymidylyltransferase, short form; Region: rmlA; TIGR01207 443906002913 substrate binding site; other site 443906002914 tetramer interface; other site 443906002915 extended (e) SDRs; Region: SDR_e; cd08946 443906002916 substrate binding site [chemical binding]; other site 443906002917 active site 443906002918 Glycosyltransferases involved in cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WcaA; COG0463 443906002919 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394 443906002920 active site 443906002921 Glycosyltransferases involved in cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WcaA; COG0463 443906002922 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cd00761 443906002923 active site 443906002924 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394 443906002925 Predicted glycosyltransferases [General function prediction only]; Region: COG1216 443906002926 active site 443906002927 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394 443906002928 active site 443906002929 UDP-galactopyranose mutase [Cell envelope biogenesis, outer membrane]; Region: Glf; COG0562 443906002930 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450 443906002931 UDP-galactopyranose mutase; Region: GLF; pfam03275 443906002932 Glycosyltransferase like family 2; Region: Glyco_tranf_2_3; pfam13641 443906002933 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394 443906002934 active site 443906002935 Predicted membrane protein [Function unknown]; Region: COG2246 443906002936 GtrA-like protein; Region: GtrA; pfam04138 443906002937 Lipid A core - O-antigen ligase and related enzymes [Cell envelope biogenesis, outer membrane]; Region: RfaL; COG3307 443906002938 O-Antigen ligase; Region: Wzy_C; pfam04932 443906002939 acyl-coenzyme A oxidase; Region: PLN02526 443906002940 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 443906002941 active site 443906002942 Alpha-Mannosidase Binding Domain of Atg19/34; Region: ABD; cl15429 443906002943 mannose-6-phosphate isomerase; Provisional; Region: PRK15131 443906002944 Alpha-Mannosidase Binding Domain of Atg19/34; Region: ABD; cl15429 443906002945 UDP-glucose 4-epimerase [Cell envelope biogenesis, outer membrane]; Region: GalE; COG1087 443906002946 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 443906002947 NAD(P) binding site [chemical binding]; other site 443906002948 active site 443906002949 Transcription factor WhiB; Region: Whib; pfam02467 443906002950 Predicted glycosyltransferases [General function prediction only]; Region: COG1216 443906002951 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394 443906002952 active site 443906002953 Minimal MMP-like domain found in a group of hypothetical proteins from alphaproteobacteria and actinobacteria; Region: MMP_TTHA0227_like_1; cd12954 443906002954 Protein of unknown function (DUF3499); Region: DUF3499; pfam12005 443906002955 The phosphomannomutase/phosphoglucomutase (PMM/PGM) bifunctional enzyme catalyzes the reversible conversion of 1-phospho to 6-phospho-sugars (e.g. between mannose-1-phosphate and mannose-6-phosphate or glucose-1-phosphate and glucose-6-phosphate) via a...; Region: PMM_PGM; cd03089 443906002956 phosphomannomutase/phosphoglucomutase; Reviewed; Region: manB; PRK09542 443906002957 active site 443906002958 substrate binding site [chemical binding]; other site 443906002959 metal binding site [ion binding]; metal-binding site 443906002960 Transcriptional regulators CsoR (copper-sensitive operon repressor), RcnR, and FrmR, and related domains; this domain superfamily was previously known as DUF156; Region: CsoR-like_DUF156; cd10148 443906002961 putative homodimer interface [polypeptide binding]; other site 443906002962 putative homotetramer interface [polypeptide binding]; other site 443906002963 putative allosteric switch controlling residues; other site 443906002964 putative metal binding site [ion binding]; other site 443906002965 putative homodimer-homodimer interface [polypeptide binding]; other site 443906002966 Heavy-metal-associated domain (HMA) is a conserved domain of approximately 30 amino acid residues found in a number of proteins that transport or detoxify heavy metals, for example, the CPx-type heavy metal ATPases and copper chaperones. HMA domain...; Region: HMA; cd00371 443906002967 metal-binding site [ion binding] 443906002968 Cation transport ATPase [Inorganic ion transport and metabolism]; Region: ZntA; COG2217 443906002969 Heavy-metal-associated domain (HMA) is a conserved domain of approximately 30 amino acid residues found in a number of proteins that transport or detoxify heavy metals, for example, the CPx-type heavy metal ATPases and copper chaperones. HMA domain...; Region: HMA; cd00371 443906002970 metal-binding site [ion binding] 443906002971 copper-(or silver)-translocating P-type ATPase; Region: ATPase-IB1_Cu; TIGR01511 443906002972 E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122 443906002973 Soluble P-type ATPase [General function prediction only]; Region: COG4087 443906002974 Adenosylhomocysteinase; Provisional; Region: PTZ00075 443906002975 S-Adenosylhomocysteine Hydrolase, NAD-binding and catalytic domains; Region: SAHH; cd00401 443906002976 homotetramer interface [polypeptide binding]; other site 443906002977 ligand binding site [chemical binding]; other site 443906002978 catalytic site [active] 443906002979 NAD binding site [chemical binding]; other site 443906002980 RDD family; Region: RDD; pfam06271 443906002981 Integral membrane protein DUF95; Region: DUF95; pfam01944 443906002982 Glycosyl hydrolase family 3 N terminal domain; Region: Glyco_hydro_3; pfam00933 443906002983 Beta-glucosidase-related glycosidases [Carbohydrate transport and metabolism]; Region: BglX; COG1472 443906002984 Glycosyl hydrolase family 3 C-terminal domain; Region: Glyco_hydro_3_C; pfam01915 443906002985 Fibronectin type III-like domain; Region: Fn3-like; pfam14310 443906002986 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 443906002987 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 443906002988 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 443906002989 Uncharacterized conserved protein (some members contain a von Willebrand factor type A (vWA) domain) [General function prediction only]; Region: COG1721 443906002990 Protein of unknown function DUF58; Region: DUF58; pfam01882 443906002991 MoxR-like ATPases [General function prediction only]; Region: COG0714 443906002992 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 443906002993 Walker A motif; other site 443906002994 ATP binding site [chemical binding]; other site 443906002995 Walker B motif; other site 443906002996 Domain of unknown function (DUF4350); Region: DUF4350; pfam14258 443906002997 Membrane domain of glycerophosphoryl diester phosphodiesterase; Region: GPDPase_memb; cl01974 443906002998 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 443906002999 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 443906003000 active site 443906003001 phosphorylation site [posttranslational modification] 443906003002 intermolecular recognition site; other site 443906003003 dimerization interface [polypeptide binding]; other site 443906003004 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 443906003005 DNA binding site [nucleotide binding] 443906003006 heavy metal sensor kinase; Region: cztS_silS_copS; TIGR01386 443906003007 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 443906003008 dimerization interface [polypeptide binding]; other site 443906003009 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 443906003010 dimer interface [polypeptide binding]; other site 443906003011 phosphorylation site [posttranslational modification] 443906003012 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 443906003013 ATP binding site [chemical binding]; other site 443906003014 Mg2+ binding site [ion binding]; other site 443906003015 G-X-G motif; other site 443906003016 lipoprotein LpqB; Provisional; Region: PRK13615 443906003017 Sporulation and spore germination; Region: Germane; pfam10646 443906003018 Predicted amidophosphoribosyltransferases [General function prediction only]; Region: ComFC; COG1040 443906003019 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 443906003020 active site 443906003021 RaiA ("ribosome-associated inhibitor A", also known as Protein Y (PY), YfiA, and SpotY, is a stress-response protein that binds the ribosomal subunit interface and arrests translation by interfering with aminoacyl-tRNA binding to the ribosomal...; Region: RaiA; cd00552 443906003022 30S subunit binding site; other site 443906003023 preprotein translocase subunit SecA; Reviewed; Region: PRK12904 443906003024 DEAD/DEAH box helicase; Region: DEAD; pfam00270 443906003025 SecA preprotein cross-linking domain; Region: SecA_PP_bind; smart00958 443906003026 Domains similar to fish antifreeze type III protein; Region: SAF; cl00555 443906003027 Antiactivator of flagellar biosynthesis FleN, an ATPase [Cell motility]; Region: flhG; COG0455 443906003028 Signal transduction histidine kinase; Region: H_kinase_N; pfam12282 443906003029 PAS fold; Region: PAS_4; pfam08448 443906003030 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: COG3920 443906003031 Histidine kinase; Region: HisKA_2; pfam07568 443906003032 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 443906003033 ATP binding site [chemical binding]; other site 443906003034 Mg2+ binding site [ion binding]; other site 443906003035 G-X-G motif; other site 443906003036 Transcription factor WhiB; Region: Whib; pfam02467 443906003037 Peroxiredoxin [Posttranslational modification, protein turnover, chaperones]; Region: AhpC; COG0450 443906003038 Peroxiredoxin (PRX) family, Bacterioferritin comigratory protein (BCP) subfamily; composed of thioredoxin-dependent thiol peroxidases, widely expressed in pathogenic bacteria, that protect cells against toxicity from reactive oxygen species by reducing...; Region: PRX_BCP; cd03017 443906003039 catalytic triad [active] 443906003040 Transcriptional regulators, similar to M. xanthus CarD [Transcription]; Region: COG1329 443906003041 Protein of unknown function (DUF1524); Region: DUF1524; pfam07510 443906003042 L-asparagine permease; Provisional; Region: PRK15049 443906003043 H+ Antiporter protein; Region: 2A0121; TIGR00900 443906003044 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 443906003045 putative substrate translocation pore; other site 443906003046 helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347 443906003047 MarR family; Region: MarR_2; pfam12802 443906003048 2-succinyl-6-hydroxy-2, 4-cyclohexadiene-1-carboxylate synthase; Region: menH_SHCHC; TIGR03695 443906003049 Glucoamylase and related glycosyl hydrolases [Carbohydrate transport and metabolism]; Region: SGA1; COG3387 443906003050 Glycosyl hydrolases family 15; Region: Glyco_hydro_15; pfam00723 443906003051 glucose-6-phosphate 1-dehydrogenase; Provisional; Region: PRK12853 443906003052 Glucose-6-phosphate dehydrogenase, NAD binding domain; Region: G6PD_N; pfam00479 443906003053 Glucose-6-phosphate dehydrogenase, C-terminal domain; Region: G6PD_C; pfam02781 443906003054 Mechanosensitive ion channel; Region: MS_channel; pfam00924 443906003055 Small-conductance mechanosensitive channel [Cell envelope biogenesis, outer membrane]; Region: MscS; COG0668 443906003056 Anion permease ArsB/NhaD. These permeases have been shown to translocate sodium, arsenate, antimonite, sulfate and organic anions across biological membranes in all three kingdoms of life. A typical anion permease contains 8-13 transmembrane helices...; Region: ArsB_NhaD_permease; cl17221 443906003057 Na+/H+ antiporter NhaD and related arsenite permeases [Inorganic ion transport and metabolism]; Region: ArsB; COG1055 443906003058 Anion permease ArsB/NhaD. These permeases have been shown to translocate sodium, arsenate, antimonite, sulfate and organic anions across biological membranes in all three kingdoms of life. A typical anion permease contains 8-13 transmembrane helices...; Region: ArsB_NhaD_permease; cl17221 443906003059 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 443906003060 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 443906003061 MMPL family; Region: MMPL; pfam03176 443906003062 YhgE/Pip N-terminal domain; Region: pip_yhgE_Nterm; TIGR03061 443906003063 YhgE/Pip C-terminal domain; Region: pip_yhgE_Cterm; TIGR03062 443906003064 Antibiotic biosynthesis monooxygenase; Region: ABM; pfam03992 443906003065 Xylose isomerase-like TIM barrel; Region: AP_endonuc_2; pfam01261 443906003066 Fructosamine kinase; Region: Fructosamin_kin; cl17579 443906003067 Trehalose-6-Phosphate Synthase (TPS) is a glycosyltransferase that catalyses the synthesis of alpha,alpha-1,1-trehalose-6-phosphate from glucose-6-phosphate using a UDP-glucose donor. It is a key enzyme in the trehalose synthesis pathway. Trehalose is a...; Region: GT1_TPS; cd03788 443906003068 alpha,alpha-trehalose-phosphate synthase [UDP-forming]; Region: trehalose_OtsA; TIGR02400 443906003069 active site 443906003070 homotetramer interface [polypeptide binding]; other site 443906003071 Trehalose-6-phosphatase [Carbohydrate transport and metabolism]; Region: OtsB; COG1877 443906003072 trehalose-6-phosphate phosphatase; Provisional; Region: PRK10187; cl17105 443906003073 putative monovalent cation/H+ antiporter subunit A; Reviewed; Region: PRK12644 443906003074 NADH-Ubiquinone/plastoquinone (complex I), various chains; Region: Oxidored_q1; pfam00361 443906003075 Multisubunit Na+/H+ antiporter, MnhB subunit [Inorganic ion transport and metabolism]; Region: MnhB; COG2111 443906003076 Domain of unknown function (DUF4040); Region: DUF4040; cl00676 443906003077 putative monovalent cation/H+ antiporter subunit C; Reviewed; Region: PRK07946 443906003078 putative monovalent cation/H+ antiporter subunit D; Reviewed; Region: PRK12665 443906003079 NADH-Ubiquinone/plastoquinone (complex I), various chains; Region: Oxidored_q1; pfam00361 443906003080 putative monovalent cation/H+ antiporter subunit E; Reviewed; Region: PRK08965 443906003081 Multiple resistance and pH regulation protein F (MrpF / PhaF); Region: MrpF_PhaF; cl09154 443906003082 putative monovalent cation/H+ antiporter subunit G; Reviewed; Region: PRK12674 443906003083 dihydroxy-acid dehydratase; Provisional; Region: PRK00911 443906003084 acetolactate synthase 1 catalytic subunit; Validated; Region: PRK07789 443906003085 Pyrimidine (PYR) binding domain of POX and related proteins; Region: TPP_PYR_POX_like; cd07035 443906003086 PYR/PP interface [polypeptide binding]; other site 443906003087 dimer interface [polypeptide binding]; other site 443906003088 TPP binding site [chemical binding]; other site 443906003089 Thiamine pyrophosphate enzyme, central domain; Region: TPP_enzyme_M; pfam00205 443906003090 Thiamine pyrophosphate (TPP) family, Acetohydroxyacid synthase (AHAS) subfamily, TPP-binding module; composed of proteins similar to the large catalytic subunit of AHAS. AHAS catalyzes the condensation of two molecules of pyruvate to give the...; Region: TPP_AHAS; cd02015 443906003091 TPP-binding site [chemical binding]; other site 443906003092 dimer interface [polypeptide binding]; other site 443906003093 acetolactate synthase 3 regulatory subunit; Reviewed; Region: ilvH; PRK11895 443906003094 N-terminal ACT domain of the Escherichia coli IlvH-like regulatory subunit of acetohydroxyacid synthase (AHAS); Region: ACT_AHAS; cd04878 443906003095 putative valine binding site [chemical binding]; other site 443906003096 dimer interface [polypeptide binding]; other site 443906003097 Small subunit of acetolactate synthase; Region: ALS_ss_C; pfam10369 443906003098 ketol-acid reductoisomerase; Provisional; Region: PRK05479 443906003099 Acetohydroxy acid isomeroreductase, catalytic domain; Region: IlvN; pfam07991 443906003100 Acetohydroxy acid isomeroreductase, catalytic domain; Region: IlvC; pfam01450 443906003101 Predicted membrane protein [Function unknown]; Region: COG4270 443906003102 D-3-phosphoglycerate dehydrogenase; Provisional; Region: PRK13581 443906003103 Phosphoglycerate dehydrogenases, NAD-binding and catalytic domains; Region: PGDH_4; cd12173 443906003104 ligand binding site [chemical binding]; other site 443906003105 NAD binding site [chemical binding]; other site 443906003106 dimerization interface [polypeptide binding]; other site 443906003107 catalytic site [active] 443906003108 C-terminal ACT (regulatory) domain of D-3-phosphoglycerate dehydrogenase (3PGDH); Region: ACT_3PGDH-xct; cd04902 443906003109 putative L-serine binding site [chemical binding]; other site 443906003110 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 443906003111 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 443906003112 methyl viologen resistance protein SmvA; Provisional; Region: PRK14995 443906003113 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 443906003114 putative substrate translocation pore; other site 443906003115 3-isopropylmalate dehydrogenase; Provisional; Region: PRK03437 443906003116 branched-chain amino acid aminotransferase; Provisional; Region: PRK13357 443906003117 BCAT_beta_family: Branched-chain aminotransferase catalyses the transamination of the branched-chain amino acids leusine, isoleucine and valine to their respective alpha-keto acids, alpha-ketoisocaproate, alpha-keto-beta-methylvalerate and...; Region: BCAT_beta_family; cd01557 443906003118 homodimer interface [polypeptide binding]; other site 443906003119 substrate-cofactor binding pocket; other site 443906003120 catalytic residue [active] 443906003121 Domain of unknown function (DUF2437); Region: DUF2437; pfam10370 443906003122 2-keto-4-pentenoate hydratase/2-oxohepta-3-ene-1,7-dioic acid hydratase (catechol pathway) [Secondary metabolites biosynthesis, transport, and catabolism]; Region: MhpD; COG0179 443906003123 Fumarylacetoacetate (FAA) hydrolase family; Region: FAA_hydrolase; pfam01557 443906003124 glutamyl-tRNA synthetase; Reviewed; Region: gltX; PRK01406 443906003125 catalytic core domain of discriminating glutamyl-tRNA synthetase; Region: GluRS_core; cd00808 443906003126 HIGH motif; other site 443906003127 catalytic core domain of discriminating glutamyl-tRNA synthetase; Region: GluRS_core; cd00808 443906003128 active site 443906003129 KMSKS motif; other site 443906003130 putative FAD-binding dehydrogenase; Reviewed; Region: PRK12834 443906003131 thioredoxin-disulfide reductase; Region: TRX_reduct; TIGR01292 443906003132 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 443906003133 Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248 443906003134 active site 443906003135 catalytic tetrad [active] 443906003136 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 443906003137 Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248 443906003138 active site 443906003139 catalytic tetrad [active] 443906003140 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 443906003141 3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05653 443906003142 classical (c) SDRs; Region: SDR_c; cd05233 443906003143 NAD(P) binding site [chemical binding]; other site 443906003144 active site 443906003145 integral membrane protein, TerC family; Region: R_switched_Alx; TIGR03718 443906003146 Predicted Zn-dependent hydrolases of the beta-lactamase fold [General function prediction only]; Region: COG2220 443906003147 Beta-lactamase superfamily domain; Region: Lactamase_B_3; pfam13483 443906003148 Type 1 glutamine amidotransferase (GATase1)-like domain found in cyanophycinase; Region: GAT1_cyanophycinase; cd03145 443906003149 proposed catalytic triad [active] 443906003150 active site nucleophile [active] 443906003151 Family 1 of Uracil-DNA glycosylase (UDG) enzymes; Region: UDG_F1; cd10027 443906003152 ligand binding site [chemical binding]; other site 443906003153 active site 443906003154 UGI interface [polypeptide binding]; other site 443906003155 catalytic site [active] 443906003156 Sortase and related acyltransferases [Cell envelope biogenesis, outer membrane]; Region: COG1247 443906003157 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 443906003158 Coenzyme A binding pocket [chemical binding]; other site 443906003159 CAAX protease self-immunity; Region: Abi; pfam02517 443906003160 TIM barrel proteins share a structurally conserved phosphate binding motif and in general share an eight beta/alpha closed barrel structure. Specific for this family is the conserved phosphate binding site at the edges of strands 7 and 8. The phosphate...; Region: TIM_phosphate_binding; cl17186 443906003161 phosphate binding site [ion binding]; other site 443906003162 Transcriptional regulators [Transcription]; Region: RpiR; COG1737 443906003163 Hexulose-6-phosphate isomerase (PHI). PHI is a member of the SIS (Sugar ISomerase domain) superfamily. In the ribulose monophosphate pathway of formaldehyde fixation, hexulose-6-phosphate synthase catalyzes the condensation of ribulose-5-phosphate with...; Region: SIS_PHI; cd05005 443906003164 tetramer interface [polypeptide binding]; other site 443906003165 active site 443906003166 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 443906003167 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 443906003168 DNA binding residues [nucleotide binding] 443906003169 dimerization interface [polypeptide binding]; other site 443906003170 5'-nucleotidase/2',3'-cyclic phosphodiesterase and related esterases [Nucleotide transport and metabolism]; Region: UshA; COG0737 443906003171 metallophosphatase superfamily, metallophosphatase domain; Region: MPP_superfamily; cl13995 443906003172 active site 443906003173 metal binding site [ion binding]; metal-binding site 443906003174 5'-nucleotidase, C-terminal domain; Region: 5_nucleotid_C; pfam02872 443906003175 Asp-tRNAAsn/Glu-tRNAGln amidotransferase A subunit and related amidases [Translation, ribosomal structure and biogenesis]; Region: GatA; COG0154 443906003176 Amidase; Region: Amidase; cl11426 443906003177 Sulfite exporter TauE/SafE; Region: TauE; pfam01925 443906003178 Siderophore-interacting protein [Inorganic ion transport and metabolism]; Region: ViuB; COG2375 443906003179 Siderophore interacting proteins share the domain structure of the ferredoxin reductase like family. Siderophores are produced in various bacteria (and some plants) to extract iron from hosts. Binding constants are high, so iron can be pilfered from...; Region: siderophore_interacting; cd06193 443906003180 FAD binding pocket [chemical binding]; other site 443906003181 FAD binding motif [chemical binding]; other site 443906003182 phosphate binding motif [ion binding]; other site 443906003183 NAD binding pocket [chemical binding]; other site 443906003184 short chain dehydrogenase; Provisional; Region: PRK06197 443906003185 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 443906003186 NAD(P) binding site [chemical binding]; other site 443906003187 active site 443906003188 Pyruvate/2-oxoglutarate dehydrogenase complex, dihydrolipoamide dehydrogenase (E3) component, and related enzymes [Energy production and conversion]; Region: Lpd; COG1249 443906003189 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 443906003190 Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain; Region: Pyr_redox_dim; pfam02852 443906003191 enoyl-CoA hydratase; Provisional; Region: PRK06563 443906003192 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 443906003193 substrate binding site [chemical binding]; other site 443906003194 oxyanion hole (OAH) forming residues; other site 443906003195 trimer interface [polypeptide binding]; other site 443906003196 Arginase-like amidino hydrolase family; Region: Arginase-like_1; cd09999 443906003197 active site 443906003198 Mn binding site [ion binding]; other site 443906003199 Predicted dinucleotide-binding enzymes [General function prediction only]; Region: COG2085 443906003200 NADP oxidoreductase coenzyme F420-dependent; Region: F420_oxidored; pfam03807 443906003201 Phage shock protein A (IM30), suppresses sigma54-dependent transcription [Transcription / Signal transduction mechanisms]; Region: PspA; COG1842 443906003202 Repair protein; Region: Repair_PSII; pfam04536 443906003203 2'-5' RNA ligase superfamily; Region: 2_5_RNA_ligase2; pfam13563 443906003204 MT0933-like antitoxin protein; Region: MT0933_antitox; pfam14013 443906003205 pyridoxamine-phosphate oxidase; Region: pdxH; TIGR00558 443906003206 Pyridoxamine 5'-phosphate oxidase; Region: Pyridox_oxidase; pfam01243 443906003207 Pyridoxine 5'-phosphate oxidase C-terminal dimerisation region; Region: PNPOx_C; pfam10590 443906003208 Subgroup of proteins having the Type 1 glutamine amidotransferase (GATase1) domain; Region: GATase1_2; cd01745 443906003209 catalytic triad [active] 443906003210 3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05557 443906003211 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 443906003212 NAD(P) binding site [chemical binding]; other site 443906003213 active site 443906003214 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 443906003215 3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05653 443906003216 NAD(P) binding site [chemical binding]; other site 443906003217 active site 443906003218 benzoate transport; Region: 2A0115; TIGR00895 443906003219 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 443906003220 putative substrate translocation pore; other site 443906003221 Catalytic domain of Helicobacter pylori peptidoglycan deacetylase (HpPgdA) and similar proteins; Region: CE4_HpPgdA_like; cd10938 443906003222 active site 443906003223 catalytic site [active] 443906003224 Zn binding site [ion binding]; other site 443906003225 tetramer interface [polypeptide binding]; other site 443906003226 Predicted xylanase/chitin deacetylase [Carbohydrate transport and metabolism]; Region: CDA1; COG0726 443906003227 Type II (periplasmic) bacterial L-asparaginase; Region: L-asparaginase_II; cd08964 443906003228 active site 443906003229 homotetramer interface [polypeptide binding]; other site 443906003230 homodimer interface [polypeptide binding]; other site 443906003231 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 443906003232 DNA binding site [nucleotide binding] 443906003233 Transcriptional regulators [Transcription]; Region: PurR; COG1609 443906003234 domain linker motif; other site 443906003235 Ligand-binding domain of uncharacterized DNA-binding regulatory proteins that are members of the LacI-GalR family of bacterial transcription repressors; Region: PBP1_LacI_like_7; cd06285 443906003236 putative dimerization interface [polypeptide binding]; other site 443906003237 putative ligand binding site [chemical binding]; other site 443906003238 Transglutaminase-like enzymes, putative cysteine proteases [Amino acid transport and metabolism]; Region: COG1305 443906003239 Transglutaminase-like superfamily; Region: Transglut_core; pfam01841 443906003240 arginyl-tRNA synthetase; Reviewed; Region: argS; PRK01611 443906003241 Arginyl tRNA synthetase N terminal dom; Region: Arg_tRNA_synt_N; smart01016 443906003242 catalytic core domain of arginyl-tRNA synthetases; Region: ArgRS_core; cd00671 443906003243 active site 443906003244 HIGH motif; other site 443906003245 KMSK motif region; other site 443906003246 tRNA binding surface [nucleotide binding]; other site 443906003247 DALR anticodon binding domain; Region: DALR_1; smart00836 443906003248 anticodon binding site; other site 443906003249 Protein of unknown function (DUF2993); Region: DUF2993; pfam11209 443906003250 diaminopimelate decarboxylase; Region: lysA; TIGR01048 443906003251 Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzyme Diaminopimelate Decarboxylase; Region: PLPDE_III_DapDC; cd06828 443906003252 active site 443906003253 pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site 443906003254 substrate binding site [chemical binding]; other site 443906003255 catalytic residues [active] 443906003256 dimer interface [polypeptide binding]; other site 443906003257 homoserine dehydrogenase; Provisional; Region: PRK06349 443906003258 Homoserine dehydrogenase, NAD binding domain; Region: NAD_binding_3; pfam03447 443906003259 Homoserine dehydrogenase; Region: Homoserine_dh; pfam00742 443906003260 ACT_HSDH_Hom CD includes the C-terminal ACT domain of the NAD(P)H-dependent, homoserine dehydrogenase (HSDH) and related domains; Region: ACT_HSDH-Hom; cd04881 443906003261 threonine synthase; Reviewed; Region: PRK06721 443906003262 Threonine synthase is a pyridoxal phosphate (PLP) dependent enzyme that catalyses the last reaction in the synthesis of threonine from aspartate. It proceeds by converting O-phospho-L-homoserine (OPH) into threonine and inorganic phosphate. In plants; Region: Thr-synth_1; cd01563 443906003263 homodimer interface [polypeptide binding]; other site 443906003264 pyridoxal 5'-phosphate binding site [chemical binding]; other site 443906003265 catalytic residue [active] 443906003266 homoserine kinase; Provisional; Region: PRK01212 443906003267 GHMP kinases N terminal domain; Region: GHMP_kinases_N; pfam00288 443906003268 Rho termination factor, N-terminal domain; Region: Rho_N; pfam07498 443906003269 transcription termination factor Rho; Provisional; Region: PRK12608 443906003270 S1_like: Ribosomal protein S1-like RNA-binding domain. Found in a wide variety of RNA-associated proteins. Originally identified in S1 ribosomal protein. This superfamily also contains the Cold Shock Domain (CSD), which is a homolog of the S1 domain; Region: S1_like; cl09927 443906003271 RNA binding site [nucleotide binding]; other site 443906003272 Transcription termination factor rho is a bacterial ATP-dependent RNA/DNA helicase. It is a homohexamer. Each monomer consists of an N-terminal domain of the OB fold, which is responsible for binding to cysteine rich nucleotides. This alignment is of the...; Region: rho_factor; cd01128 443906003273 multimer interface [polypeptide binding]; other site 443906003274 Walker A motif; other site 443906003275 ATP binding site [chemical binding]; other site 443906003276 Walker B motif; other site 443906003277 peptide chain release factor 1; Validated; Region: prfA; PRK00591 443906003278 This domain is found in peptide chain release factors; Region: PCRF; smart00937 443906003279 RF-1 domain; Region: RF-1; pfam00472 443906003280 N5-glutamine S-adenosyl-L-methionine-dependent methyltransferase; Provisional; Region: PRK09328 443906003281 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl17173 443906003282 Haloacid dehalogenase-like hydrolase; Region: HAD_2; pfam13419 443906003283 ?-D-glucose-1-phosphatase; Provisional; Region: PRK09456 443906003284 Putative translation factor (SUA5) [Translation, ribosomal structure and biogenesis]; Region: SUA5; COG0009 443906003285 UDP-N-acetylmuramyl pentapeptide phosphotransferase/UDP-N- acetylglucosamine-1-phosphate transferase [Cell envelope biogenesis, outer membrane]; Region: Rfe; COG0472 443906003286 This subfamily contains Escherichia coli WecA, Bacillus subtilis TagO and related proteins. WecA is an UDP-N-acetylglucosamine (GlcNAc):undecaprenyl-phosphate (Und-P) GlcNAc-1-phosphate transferase that catalyzes the formation of a phosphodiester bond...; Region: GT_WecA_like; cd06853 443906003287 Mg++ binding site [ion binding]; other site 443906003288 putative catalytic motif [active] 443906003289 substrate binding site [chemical binding]; other site 443906003290 F0F1 ATP synthase subunit A; Validated; Region: PRK05815 443906003291 ATP synthase subunit C; Region: ATP-synt_C; cl00466 443906003292 F0F1 ATP synthase subunit B; Validated; Region: PRK05759 443906003293 F0F1 ATP synthase subunit delta; Provisional; Region: PRK13430 443906003294 ATP synthase delta (OSCP) subunit; Region: OSCP; pfam00213 443906003295 F0F1 ATP synthase subunit alpha; Validated; Region: PRK09281 443906003296 ATP synthase alpha/beta family, beta-barrel domain; Region: ATP-synt_ab_N; pfam02874 443906003297 F1 ATP synthase alpha, central domain. The F-ATPase is found in bacterial plasma membranes, mitochondrial inner membranes and in chloroplast thylakoid membranes. It has also been found in the archaea Methanosarcina barkeri. It uses a proton gradient to...; Region: F1_ATPase_alpha; cd01132 443906003298 beta subunit interaction interface [polypeptide binding]; other site 443906003299 Walker A motif; other site 443906003300 ATP binding site [chemical binding]; other site 443906003301 Walker B motif; other site 443906003302 ATP synthase alpha/beta chain, C terminal domain; Region: ATP-synt_ab_C; pfam00306 443906003303 mitochondrial ATP synthase gamma subunit; Region: F1-ATPase_gamma; cd12151 443906003304 core domain interface [polypeptide binding]; other site 443906003305 delta subunit interface [polypeptide binding]; other site 443906003306 epsilon subunit interface [polypeptide binding]; other site 443906003307 F0F1 ATP synthase subunit beta; Validated; Region: PRK09280 443906003308 ATP synthase alpha/beta family, beta-barrel domain; Region: ATP-synt_ab_N; pfam02874 443906003309 F1 ATP synthase beta subunit, nucleotide-binding domain. The F-ATPase is found in bacterial plasma membranes, mitochondrial inner membranes and in chloroplast thylakoid membranes. It has also been found in the archaea Methanosarcina barkeri. It uses a...; Region: F1-ATPase_beta; cd01133 443906003310 alpha subunit interaction interface [polypeptide binding]; other site 443906003311 Walker A motif; other site 443906003312 ATP binding site [chemical binding]; other site 443906003313 Walker B motif; other site 443906003314 inhibitor binding site; inhibition site 443906003315 ATP synthase alpha/beta chain, C terminal domain; Region: ATP-synt_ab_C; pfam00306 443906003316 mitochondrial ATP synthase delta subunit; Region: F1-ATPase_delta; cd12152 443906003317 gamma subunit interface [polypeptide binding]; other site 443906003318 epsilon subunit interface [polypeptide binding]; other site 443906003319 LBP interface [polypeptide binding]; other site 443906003320 hypothetical protein; Validated; Region: PRK02101 443906003321 Methyladenine glycosylase; Region: Adenine_glyco; pfam03352 443906003322 Methylated DNA-protein cysteine methyltransferase [DNA replication, recombination, and repair]; Region: Ada; COG0350 443906003323 6-O-methylguanine DNA methyltransferase, ribonuclease-like domain; Region: Methyltransf_1N; pfam02870 443906003324 The DNA repair protein O6-alkylguanine-DNA alkyltransferase (ATase; also known as AGT, AGAT and MGMT) reverses O6-alkylation DNA damage by transferring O6-alkyl adducts to an active site cysteine irreversibly, without inducing DNA strand breaks. ATases...; Region: ATase; cd06445 443906003325 DNA binding site [nucleotide binding] 443906003326 active site 443906003327 helix_turn_helix ASNC type; Region: HTH_ASNC; smart00344 443906003328 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 443906003329 putative DNA binding site [nucleotide binding]; other site 443906003330 putative Zn2+ binding site [ion binding]; other site 443906003331 AsnC family; Region: AsnC_trans_reg; pfam01037 443906003332 Serine/threonine phosphatases, family 2C, catalytic domain; The protein architecture and deduced catalytic mechanism of PP2C phosphatases are similar to the PP1, PP2A, PP2B family of protein Ser/Thr phosphatases, with which PP2C shares no sequence...; Region: PP2Cc; cd00143 443906003333 Protein phosphatase 2C; Region: PP2C; pfam00481 443906003334 active site 443906003335 2,3,4,5-tetrahydropyridine-2,6-dicarboxylate N-succinyltransferase; Region: DapD_actino; TIGR03535 443906003336 Putative 2,3,4,5-tetrahydropyridine-2,6-dicarboxylate (THDP) N-succinyltransferase (THP succinyltransferase), C-terminal left-handed parallel alpha-helix (LbH) domain: This group is composed of mostly uncharacterized proteins containing an N-terminal...; Region: LbH_THP_succinylT_putative; cd04649 443906003337 putative trimer interface [polypeptide binding]; other site 443906003338 putative CoA binding site [chemical binding]; other site 443906003339 succinyl-diaminopimelate desuccinylase; Reviewed; Region: PRK13007 443906003340 M20 Peptidase actinobacterial DapE encoded N-succinyl-L,L-diaminopimelic acid desuccinylase; Region: M20_DapE_actinobac; cd05647 443906003341 metal binding site [ion binding]; metal-binding site 443906003342 putative dimer interface [polypeptide binding]; other site 443906003343 Protein of unknown function (DUF3117); Region: DUF3117; pfam11314 443906003344 Predicted O-methyltransferase [General function prediction only]; Region: COG4122 443906003345 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 443906003346 S-adenosylmethionine binding site [chemical binding]; other site 443906003347 mttA/Hcf106 family; Region: MttA_Hcf106; cl00788 443906003348 Transcriptional regulator [Transcription]; Region: LysR; COG0583 443906003349 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 443906003350 The C-terminal substrate binding domain of an uncharacterized LysR-type transcriptional regulator, contains the type 2 periplasmic binding fold; Region: PBP2_LTTR_like_6; cd08423 443906003351 putative dimerization interface [polypeptide binding]; other site 443906003352 Domain of unknown function DUF59; Region: DUF59; cl00941 443906003353 ATPases involved in chromosome partitioning [Cell division and chromosome partitioning]; Region: Mrp; COG0489 443906003354 The Fer4_NifH superfamily contains a variety of proteins which share a common ATP-binding domain. Functionally, proteins in this superfamily use the energy from hydrolysis of NTP to transfer electron or ion; Region: Fer4_NifH; cl17203 443906003355 Protein of unknown function (DUF1003); Region: DUF1003; pfam06210 443906003356 MgtE intracellular N domain; Region: MgtE_N; smart00924 443906003357 FOG: CBS domain [General function prediction only]; Region: COG0517 443906003358 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domain in the magnesium transporter, MgtE. MgtE and its homologs are found in eubacteria, archaebacteria, and eukaryota. Members of this family transport Mg2+ or other...; Region: CBS_pair_Mg_transporter; cd04606 443906003359 Aminopeptidase P, N-terminal domain; Region: AMP_N; smart01011 443906003360 Prolidase. E.C. 3.4.13.9. Also known as Xaa-Pro dipeptidase, X-Pro dipeptidase, proline dipeptidase., imidodipeptidase, peptidase D, gamma-peptidase. Catalyses hydrolysis of Xaa-Pro dipeptides; also acts on aminoacyl-hydroxyproline analogs. No action on...; Region: Prolidase; cd01087 443906003361 active site 443906003362 Exonuclease-Endonuclease-Phosphatase (EEP) domain superfamily; Region: EEP; cl00490 443906003363 putative catalytic site [active] 443906003364 putative phosphate binding site [ion binding]; other site 443906003365 putative metal binding site [ion binding]; other site 443906003366 Predicted metal-dependent phosphoesterases (PHP family) [General function prediction only]; Region: COG0613 443906003367 Polymerase and Histidinol Phosphatase domain of Histidinol phosphate phosphatase (HisPPase) AMP bound; Region: PHP_HisPPase_AMP; cd07438 443906003368 active site 443906003369 Polymerase and Histidinol Phosphatase domain of Histidinol phosphate phosphatase (HisPPase) AMP bound; Region: PHP_HisPPase_AMP; cd07438 443906003370 ATP-dependent RNA helicase RhlB; Provisional; Region: PRK04837 443906003371 DEAD-box helicases. A diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker B motif; Region: DEADc; cd00268 443906003372 ATP binding site [chemical binding]; other site 443906003373 Mg++ binding site [ion binding]; other site 443906003374 motif III; other site 443906003375 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 443906003376 nucleotide binding region [chemical binding]; other site 443906003377 ATP-binding site [chemical binding]; other site 443906003378 tRNA-(MS[2]IO[6]A)-hydroxylase (MiaE)-like; Region: MiaE_2; pfam13794 443906003379 Protein of unknown function (DUF3107); Region: DUF3107; pfam11305 443906003380 UvrD/REP helicase N-terminal domain; Region: UvrD-helicase; pfam00580 443906003381 Part of AAA domain; Region: AAA_19; pfam13245 443906003382 PD-(D/E)XK nuclease superfamily; Region: PDDEXK_1; pfam12705 443906003383 UvrD/REP helicase N-terminal domain; Region: UvrD-helicase; pfam00580 443906003384 Part of AAA domain; Region: AAA_19; pfam13245 443906003385 Superfamily I DNA and RNA helicases [DNA replication, recombination, and repair]; Region: UvrD; COG0210 443906003386 Family description; Region: UvrD_C_2; pfam13538 443906003387 PD-(D/E)XK nuclease superfamily; Region: PDDEXK_1; pfam12705 443906003388 Aminoglycoside 3'-phosphotransferase (APH) and Choline Kinase (ChoK) family. The APH/ChoK family is part of a larger superfamily that includes the catalytic domains of other kinases, such as the typical serine/threonine/tyrosine protein kinases (PKs)...; Region: APH_ChoK_like; cl17270 443906003389 active site 443906003390 ATP binding site [chemical binding]; other site 443906003391 Phosphotransferase enzyme family; Region: APH; pfam01636 443906003392 substrate binding site [chemical binding]; other site 443906003393 NTP pyrophosphohydrolases containing a Zn-finger, probably nucleic-acid-binding [DNA replication, recombination, and repair]; Region: NPY1; COG2816 443906003394 NADH pyrophosphatase zinc ribbon domain; Region: zf-NADH-PPase; pfam09297 443906003395 NADH pyrophosphatase, a member of the Nudix hydrolase superfamily, catalyzes the cleavage of NADH into reduced nicotinamide mononucleotide (NMNH) and AMP. Like other members of the Nudix family, it requires a divalent cation, such as Mg2+ or Mn2+, for...; Region: NADH_pyrophosphatase; cd03429 443906003396 putative NADH binding site [chemical binding]; other site 443906003397 putative active site [active] 443906003398 nudix motif; other site 443906003399 putative metal binding site [ion binding]; other site 443906003400 Superfamily I DNA and RNA helicases [DNA replication, recombination, and repair]; Region: UvrD; COG0210 443906003401 Part of AAA domain; Region: AAA_19; pfam13245 443906003402 Family description; Region: UvrD_C_2; pfam13538 443906003403 glutamate synthases, NADH/NADPH, small subunit; Region: GOGAT_sm_gam; TIGR01317 443906003404 uncharacterized protein, coenzyme F420 biosynthesis associated; Region: DUF2342_F420; TIGR03883 443906003405 Uncharacterized conserved protein (DUF2342); Region: DUF2342; pfam10103 443906003406 Predicted secreted protein containing a PDZ domain [Signal transduction mechanisms]; Region: SdrC; COG3480 443906003407 Lon protease (S16) C-terminal proteolytic domain; Region: Lon_C; pfam05362 443906003408 Uncharacterized conserved protein [Function unknown]; Region: COG1615 443906003409 Uncharacterized protein family (UPF0182); Region: UPF0182; pfam03699 443906003410 Peroxiredoxin (PRX)-like 2 family; hypothetical proteins that show sequence similarity to PRXs. Members of this group contain a CXXC motif, similar to TRX. The second cysteine in the motif corresponds to the peroxidatic cysteine of PRX, however, these...; Region: PRX_like2; cd02970 443906003411 putative catalytic residues [active] 443906003412 Predicted unusual protein kinase [General function prediction only]; Region: AarF; COG0661 443906003413 ABC1 family; Region: ABC1; cl17513 443906003414 Predicted transcriptional regulators [Transcription]; Region: COG1695 443906003415 Transcriptional regulator PadR-like family; Region: PadR; pfam03551 443906003416 lipoyl synthase; Provisional; Region: PRK05481 443906003417 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 443906003418 FeS/SAM binding site; other site 443906003419 lipoate-protein ligase B; Provisional; Region: PRK14345 443906003420 Siderophore-interacting protein [Inorganic ion transport and metabolism]; Region: ViuB; COG2375 443906003421 Siderophore interacting proteins share the domain structure of the ferredoxin reductase like family. Siderophores are produced in various bacteria (and some plants) to extract iron from hosts. Binding constants are high, so iron can be pilfered from...; Region: siderophore_interacting; cd06193 443906003422 FAD binding pocket [chemical binding]; other site 443906003423 FAD binding motif [chemical binding]; other site 443906003424 phosphate binding motif [ion binding]; other site 443906003425 NAD binding pocket [chemical binding]; other site 443906003426 Uncharacterized conserved protein [Function unknown]; Region: COG1284 443906003427 Domain of unknown function (DUF3817); Region: DUF3817; pfam12823 443906003428 Domain of unknown function (DUF303); Region: DUF303; pfam03629 443906003429 Cation efflux family; Region: Cation_efflux; cl00316 443906003430 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 443906003431 dimerization interface [polypeptide binding]; other site 443906003432 putative DNA binding site [nucleotide binding]; other site 443906003433 putative Zn2+ binding site [ion binding]; other site 443906003434 Protein-tyrosine-phosphatase [Signal transduction mechanisms]; Region: Wzb; COG0394 443906003435 Low molecular weight phosphatase family; Region: LMWPc; cl00105 443906003436 active site 443906003437 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 443906003438 Esterases and lipases (includes fungal lipases, cholinesterases, etc.) These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cd00312 443906003439 Carboxylesterase type B [Lipid metabolism]; Region: PnbA; COG2272 443906003440 substrate binding pocket [chemical binding]; other site 443906003441 catalytic triad [active] 443906003442 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 443906003443 Acetyltransferase (GNAT) domain; Region: Acetyltransf_3; pfam13302 443906003444 Acetyltransferase (GNAT) family; Region: Acetyltransf_1; pfam00583 443906003445 Superfamily II DNA and RNA helicases [DNA replication, recombination, and repair / Transcription / Translation, ribosomal structure and biogenesis]; Region: SrmB; COG0513 443906003446 DEAD-box helicases. A diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker B motif; Region: DEADc; cd00268 443906003447 ATP binding site [chemical binding]; other site 443906003448 Mg++ binding site [ion binding]; other site 443906003449 motif III; other site 443906003450 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 443906003451 nucleotide binding region [chemical binding]; other site 443906003452 ATP-binding site [chemical binding]; other site 443906003453 RNA recognition motif in Escherichia coli cold-shock DEAD box protein A (CsdA) and similar proteins; Region: RRM_EcCsdA_like; cd12499 443906003454 putative RNA binding site [nucleotide binding]; other site 443906003455 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 443906003456 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 443906003457 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 443906003458 non-specific DNA binding site [nucleotide binding]; other site 443906003459 salt bridge; other site 443906003460 sequence-specific DNA binding site [nucleotide binding]; other site 443906003461 Cupin domain; Region: Cupin_2; pfam07883 443906003462 Predicted esterase [General function prediction only]; Region: COG0400 443906003463 putative hydrolase; Provisional; Region: PRK11460 443906003464 N-terminal domain of Sphingobium chlorophenolicum 2,6-dichloro-p-hydroquinone 1,2-dioxygenase (PcpA), and similar proteins; Region: PcpA_N_like; cd08346 443906003465 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 443906003466 Zn binding site [ion binding]; other site 443906003467 C-terminal domain of Sphingobium chlorophenolicum 2,6-dichloro-p-hydroquinone 1,2-dioxygenase (PcpA), and similar proteins; Region: PcpA_C_like; cd08347 443906003468 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 443906003469 Zn binding site [ion binding]; other site 443906003470 Domain of unknown function (DU1801); Region: DUF1801; pfam08818 443906003471 progesterone 5-beta-reductase-like proteins (5beta-POR), atypical (a) SDRs; Region: 5beta-POR_like_SDR_a; cd08948 443906003472 NAD dependent epimerase/dehydratase family; Region: Epimerase; pfam01370 443906003473 NAD(P) binding site [chemical binding]; other site 443906003474 active site 443906003475 Protein of unknown function (DUF418); Region: DUF418; pfam04235 443906003476 ABC-type multidrug transport system, ATPase component [Defense mechanisms]; Region: CcmA; COG1131 443906003477 ATP-binding cassette domain of the drug resistance transporter and related proteins, subfamily A; Region: ABC_DR_subfamily_A; cd03230 443906003478 Walker A/P-loop; other site 443906003479 ATP binding site [chemical binding]; other site 443906003480 Q-loop/lid; other site 443906003481 ABC transporter signature motif; other site 443906003482 Walker B; other site 443906003483 D-loop; other site 443906003484 H-loop/switch region; other site 443906003485 ABC-type multidrug transport system, permease component [Defense mechanisms]; Region: COG0842 443906003486 ABC-2 type transporter; Region: ABC2_membrane; pfam01061 443906003487 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: COG4585 443906003488 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 443906003489 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 443906003490 active site 443906003491 phosphorylation site [posttranslational modification] 443906003492 intermolecular recognition site; other site 443906003493 dimerization interface [polypeptide binding]; other site 443906003494 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 443906003495 DNA binding residues [nucleotide binding] 443906003496 dimerization interface [polypeptide binding]; other site 443906003497 ABC-type xylose transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: XylF; COG4213 443906003498 Periplasmic xylose-binding component of the ABC-type transport systems that belong to a family of pentose/hexose sugar-binding proteins of the type I periplasmic binding protein (PBP1) superfamily; Region: PBP1_ABC_xylose_binding; cd01538 443906003499 putative ligand binding site [chemical binding]; other site 443906003500 xylose transporter ATP-binding subunit; Provisional; Region: PRK13549 443906003501 First domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_I; cd03216 443906003502 Walker A/P-loop; other site 443906003503 ATP binding site [chemical binding]; other site 443906003504 Q-loop/lid; other site 443906003505 ABC transporter signature motif; other site 443906003506 Walker B; other site 443906003507 D-loop; other site 443906003508 H-loop/switch region; other site 443906003509 Second domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_II; cd03215 443906003510 Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653 443906003511 Transmembrane subunit (TM) of Escherichia coli AraH and related proteins. E. coli AraH is the TM of a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of the monosaccharide arabinose. This group...; Region: TM_PBP1_transp_AraH_like; cd06579 443906003512 Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653 443906003513 TM-ABC transporter signature motif; other site 443906003514 The S26 Type I signal peptidase (SPase; LepB; leader peptidase B; leader peptidase I; EC 3.4.21.89) family members are essential membrane-bound serine proteases that function to cleave the amino-terminal signal peptide extension from proteins that are...; Region: S26_SPase_I; cd06530 443906003515 Catalytic site [active] 443906003516 alternate signal-mediated exported protein, RER_14450 family; Region: exp_by_SipW_III; TIGR04089 443906003517 phosphate regulon sensor kinase PhoR; Region: phoR_proteo; TIGR02966 443906003518 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 443906003519 dimer interface [polypeptide binding]; other site 443906003520 phosphorylation site [posttranslational modification] 443906003521 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 443906003522 ATP binding site [chemical binding]; other site 443906003523 Mg2+ binding site [ion binding]; other site 443906003524 G-X-G motif; other site 443906003525 BCCT family transporter; Region: BCCT; pfam02028 443906003526 Sphingosine kinase and enzymes related to eukaryotic diacylglycerol kinase [Lipid metabolism / General function prediction only]; Region: LCB5; COG1597 443906003527 Diacylglycerol kinase catalytic domain; Region: DAGK_cat; pfam00781 443906003528 Predicted ATPase [General function prediction only]; Region: COG4637 443906003529 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 443906003530 Walker A/P-loop; other site 443906003531 ATP binding site [chemical binding]; other site 443906003532 Fatty acid desaturase; Region: FA_desaturase; pfam00487 443906003533 The Delta6 Fatty Acid Desaturase (Delta6-FADS)-like CD includes the integral-membrane enzymes: delta-4, delta-5, delta-6, delta-8, delta-8-sphingolipid, and delta-11 desaturases found in vertebrates, higher plants, fungi, and bacteria. These desaturases...; Region: Delta6-FADS-like; cd03506 443906003534 putative di-iron ligands [ion binding]; other site 443906003535 Zn-dependent alcohol dehydrogenases [General function prediction only]; Region: AdhP; COG1064 443906003536 D-arabinose dehydrogenase; Region: arabinose_DH_like; cd05284 443906003537 NAD binding site [chemical binding]; other site 443906003538 substrate binding site [chemical binding]; other site 443906003539 catalytic Zn binding site [ion binding]; other site 443906003540 structural Zn binding site [ion binding]; other site 443906003541 Protein of unknown function (DUF664); Region: DUF664; pfam04978 443906003542 DinB superfamily; Region: DinB_2; pfam12867 443906003543 N-terminal catalytic domain of endoplasmic reticulum(ER)/cytosolic class II alpha-mannosidases; glycoside hydrolase family 38 (GH38); Region: GH38N_AMII_ER_cytosolic; cd10789 443906003544 active site 443906003545 catalytic site [active] 443906003546 Alpha mannosidase, middle domain; Region: Alpha-mann_mid; smart00872 443906003547 Glycosyl hydrolases family 38 C-terminal domain; Region: Glyco_hydro_38C; pfam07748 443906003548 ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395 443906003549 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 443906003550 dimer interface [polypeptide binding]; other site 443906003551 conserved gate region; other site 443906003552 putative PBP binding loops; other site 443906003553 ABC-ATPase subunit interface; other site 443906003554 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 443906003555 dimer interface [polypeptide binding]; other site 443906003556 conserved gate region; other site 443906003557 putative PBP binding loops; other site 443906003558 ABC-ATPase subunit interface; other site 443906003559 ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653 443906003560 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; pfam01547 443906003561 helix_turn_helix, cAMP Regulatory protein C-terminus; DNA binding domain of prokaryotic regulatory proteins belonging to the catabolite activator protein family; Region: HTH_CRP; cd00092 443906003562 non-specific DNA interactions [nucleotide binding]; other site 443906003563 DNA binding site [nucleotide binding] 443906003564 sequence specific DNA binding site [nucleotide binding]; other site 443906003565 putative cAMP binding site [chemical binding]; other site 443906003566 Transcriptional regulator/sugar kinase [Transcription / Carbohydrate transport and metabolism]; Region: NagC; COG1940 443906003567 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cd00012 443906003568 Zinc finger domain containing protein (CDGSH-type) [Function unknown]; Region: COG3369 443906003569 Iron-binding zinc finger CDGSH type; Region: zf-CDGSH; pfam09360 443906003570 Putative neutral zinc metallopeptidase; Region: Zn_peptidase; pfam04228 443906003571 A new structural DNA glycosylase; Region: AlkD_like; cl11434 443906003572 Nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: WcaG; COG0451 443906003573 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 443906003574 NAD(P) binding site [chemical binding]; other site 443906003575 active site 443906003576 Domain of unknown function (DUF2017); Region: DUF2017; pfam09438 443906003577 ATP-dependent Clp protease adaptor protein ClpS; Region: ClpS; cl00933 443906003578 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 443906003579 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 443906003580 active site 443906003581 phosphorylation site [posttranslational modification] 443906003582 intermolecular recognition site; other site 443906003583 dimerization interface [polypeptide binding]; other site 443906003584 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 443906003585 DNA binding residues [nucleotide binding] 443906003586 dimerization interface [polypeptide binding]; other site 443906003587 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: COG4585 443906003588 Histidine kinase; Region: HisKA_3; pfam07730 443906003589 Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase; Region: HATPase_c; pfam02518 443906003590 ABC-2 family transporter protein; Region: ABC2_membrane_4; pfam12730 443906003591 ABC-type multidrug transport system, ATPase component [Defense mechanisms]; Region: CcmA; COG1131 443906003592 ATP-binding cassette domain of the bacitracin-resistance transporter; Region: ABC_BcrA_bacitracin_resist; cd03268 443906003593 Walker A/P-loop; other site 443906003594 ATP binding site [chemical binding]; other site 443906003595 Q-loop/lid; other site 443906003596 ABC transporter signature motif; other site 443906003597 Walker B; other site 443906003598 D-loop; other site 443906003599 H-loop/switch region; other site 443906003600 aminotransferase; Validated; Region: PRK07777 443906003601 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 443906003602 pyridoxal 5'-phosphate binding site [chemical binding]; other site 443906003603 homodimer interface [polypeptide binding]; other site 443906003604 catalytic residue [active] 443906003605 Trypsin-like peptidase domain; Region: Trypsin_2; pfam13365 443906003606 PDZ domain of tryspin-like serine proteases, such as DegP/HtrA, which are oligomeric proteins involved in heat-shock response, chaperone function, and apoptosis. May be responsible for substrate recognition and/or binding, as most PDZ domains bind...; Region: PDZ_serine_protease; cd00987 443906003607 protein binding site [polypeptide binding]; other site 443906003608 Glycosyltransferase like family 2; Region: Glyco_tranf_2_3; pfam13641 443906003609 ExoA is involved in the biosynthesis of succinoglycan; Region: Succinoglycan_BP_ExoA; cd02525 443906003610 Ligand binding site; other site 443906003611 CDP-alcohol phosphatidyltransferase; Region: CDP-OH_P_transf; pfam01066 443906003612 Predicted glycosyltransferases [General function prediction only]; Region: COG1216 443906003613 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394 443906003614 CDP-Glycerol:Poly(glycerophosphate) glycerophosphotransferase; Region: Glyphos_transf; pfam04464 443906003615 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 443906003616 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 443906003617 non-specific DNA binding site [nucleotide binding]; other site 443906003618 salt bridge; other site 443906003619 sequence-specific DNA binding site [nucleotide binding]; other site 443906003620 ABC-type polysaccharide/polyol phosphate transport system, ATPase component [Carbohydrate transport and metabolism / Cell envelope biogenesis, outer membrane]; Region: TagH; COG1134 443906003621 ATP-binding cassette component of polysaccharide transport system; Region: ABC_KpsT_Wzt; cd03220 443906003622 Walker A/P-loop; other site 443906003623 ATP binding site [chemical binding]; other site 443906003624 Q-loop/lid; other site 443906003625 ABC transporter signature motif; other site 443906003626 Walker B; other site 443906003627 D-loop; other site 443906003628 H-loop/switch region; other site 443906003629 ABC-type polysaccharide/polyol phosphate export systems, permease component [Carbohydrate transport and metabolism / Cell envelope biogenesis, outer membrane]; Region: TagG; COG1682 443906003630 ABC-2 type transporter; Region: ABC2_membrane; pfam01061 443906003631 Phosphocholine cytidylyltransferases catalyze the synthesis of CDP-choline; Region: PC_cytidylyltransferase; cd02523 443906003632 active site 443906003633 metal-binding site 443906003634 ABC-type Na+ transport system, ATPase component [Energy production and conversion / Inorganic ion transport and metabolism]; Region: NatA; COG4555 443906003635 ATP-binding cassette domain of the drug resistance transporter and related proteins, subfamily A; Region: ABC_DR_subfamily_A; cd03230 443906003636 Walker A/P-loop; other site 443906003637 ATP binding site [chemical binding]; other site 443906003638 Q-loop/lid; other site 443906003639 ABC transporter signature motif; other site 443906003640 Walker B; other site 443906003641 D-loop; other site 443906003642 H-loop/switch region; other site 443906003643 Protein of unknown function (DUF3039); Region: DUF3039; pfam11238 443906003644 nicotinate phosphoribosyltransferase; Validated; Region: PRK09243 443906003645 Nicotinate phosphoribosyltransferase (NAPRTase), subgroup A. Nicotinate phosphoribosyltransferase catalyses the formation of NAMN and PPi from 5-phosphoribosy -1-pyrophosphate (PRPP) and nicotinic acid, this is the first, and also rate limiting, reaction...; Region: NAPRTase_A; cd01570 443906003646 active site 443906003647 Uncharacterized protein related to deoxyribodipyrimidine photolyase [General function prediction only]; Region: COG3046 443906003648 Deoxyribodipyrimidine photo-lyase-related protein; Region: DPRP; pfam04244 443906003649 glutamate racemase; Provisional; Region: PRK00865 443906003650 ribonuclease PH; Reviewed; Region: rph; PRK00173 443906003651 Ribonuclease PH; Region: RNase_PH_bact; cd11362 443906003652 hexamer interface [polypeptide binding]; other site 443906003653 active site 443906003654 NTPase/HAM1. This family consists of the HAM1 protein and pyrophosphate-releasing xanthosine/ inosine triphosphatase. HAM1 protects the cell against mutagenesis by the base analog 6-N-hydroxylaminopurine (HAP) in E. Coli and S. cerevisiae. A...; Region: HAM1; cd00515 443906003655 active site 443906003656 dimerization interface [polypeptide binding]; other site 443906003657 Co/Zn/Cd efflux system component [Inorganic ion transport and metabolism]; Region: CzcD; COG1230 443906003658 Uncharacterized membrane-associated protein [Function unknown]; Region: DedA; COG0586 443906003659 SNARE associated Golgi protein; Region: SNARE_assoc; cl00429 443906003660 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cl17037 443906003661 D-xylulose kinase; Region: XylB; TIGR01312 443906003662 nucleotide binding site [chemical binding]; other site 443906003663 Type IV secretory pathway, VirB11 components, and related ATPases involved in archaeal flagella biosynthesis [Cell motility and secretion / Intracellular trafficking and secretion]; Region: VirB11; COG0630 443906003664 Type IV secretory pathway component VirB11, and related ATPases. The homohexamer, VirB11 is one of eleven Vir proteins, which are required for T-pilus biogenesis and virulence in the transfer of T-DNA from the Ti (tumor-inducing) plasmid of bacterial to...; Region: VirB11-like_ATPase; cd01130 443906003665 ATP binding site [chemical binding]; other site 443906003666 Walker A motif; other site 443906003667 hexamer interface [polypeptide binding]; other site 443906003668 Walker B motif; other site 443906003669 Type II secretion system (T2SS), protein F; Region: T2SF; pfam00482 443906003670 Flp pilus assembly protein TadC [Cell motility and secretion / Intracellular trafficking and secretion]; Region: TadC; COG2064 443906003671 Type II secretion system (T2SS), protein F; Region: T2SF; pfam00482 443906003672 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 443906003673 Major Facilitator Superfamily; Region: MFS_1; pfam07690 443906003674 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 443906003675 putative substrate translocation pore; other site 443906003676 peptide chain release factor 2; Validated; Region: prfB; PRK00578 443906003677 This domain is found in peptide chain release factors; Region: PCRF; smart00937 443906003678 RF-1 domain; Region: RF-1; pfam00472 443906003679 Predicted ATPase involved in cell division [Cell division and chromosome partitioning]; Region: FtsE; COG2884 443906003680 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 443906003681 Walker A/P-loop; other site 443906003682 ATP binding site [chemical binding]; other site 443906003683 Q-loop/lid; other site 443906003684 ABC transporter signature motif; other site 443906003685 Walker B; other site 443906003686 D-loop; other site 443906003687 H-loop/switch region; other site 443906003688 Cell division protein [Cell division and chromosome partitioning]; Region: FtsX; COG2177 443906003689 FtsX-like permease family; Region: FtsX; pfam02687 443906003690 Small protein B (SmpB) is a component of the trans-translation system in prokaryotes for releasing stalled ribosome from damaged messenger RNAs; Region: SmpB; cd09294 443906003691 SmpB-tmRNA interface; other site 443906003692 ABC-type Fe3+ transport system, permease component [Inorganic ion transport and metabolism]; Region: ThiP; COG1178 443906003693 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 443906003694 dimer interface [polypeptide binding]; other site 443906003695 conserved gate region; other site 443906003696 ABC-ATPase subunit interface; other site 443906003697 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 443906003698 putative PBP binding loops; other site 443906003699 dimer interface [polypeptide binding]; other site 443906003700 ABC-ATPase subunit interface; other site 443906003701 ABC-type spermidine/putrescine transport systems, ATPase components [Amino acid transport and metabolism]; Region: PotA; COG3842 443906003702 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 443906003703 Walker A/P-loop; other site 443906003704 ATP binding site [chemical binding]; other site 443906003705 Q-loop/lid; other site 443906003706 ABC transporter signature motif; other site 443906003707 Walker B; other site 443906003708 D-loop; other site 443906003709 H-loop/switch region; other site 443906003710 TOBE domain; Region: TOBE_2; pfam08402 443906003711 Bacterial extracellular solute-binding protein; Region: SBP_bac_8; pfam13416 443906003712 Bacterial extracellular solute-binding protein; Region: SBP_bac_6; pfam13343 443906003713 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 443906003714 putative substrate translocation pore; other site 443906003715 Archaeal fructose-1,6-bisphosphatase and related enzymes of inositol monophosphatase family [Carbohydrate transport and metabolism]; Region: SuhB; COG0483 443906003716 FIG, FBPase/IMPase/glpX-like domain. A superfamily of metal-dependent phosphatases with various substrates. Fructose-1,6-bisphospatase (both the major and the glpX-encoded variant) hydrolyze fructose-1,6,-bisphosphate to fructose-6-phosphate in...; Region: FIG; cl00289 443906003717 active site 443906003718 Predicted GTPases [General function prediction only]; Region: COG1162 443906003719 Ribosomal interacting GTPase YjeQ/EngC, a circularly permuted subfamily of the Ras GTPases; Region: YjeQ_EngC; cd01854 443906003720 GTPase/Zn-binding domain interface [polypeptide binding]; other site 443906003721 GTP/Mg2+ binding site [chemical binding]; other site 443906003722 G4 box; other site 443906003723 G5 box; other site 443906003724 G1 box; other site 443906003725 Switch I region; other site 443906003726 G2 box; other site 443906003727 G3 box; other site 443906003728 Switch II region; other site 443906003729 3-phosphoshikimate 1-carboxyvinyltransferase; Provisional; Region: PRK02427 443906003730 EPSP synthase domain. 3-phosphoshikimate 1-carboxyvinyltransferase (5-enolpyruvylshikimate-3-phosphate synthase) (EC 2.5.1.19) catalyses the reaction between shikimate-3-phosphate (S3P) and phosphoenolpyruvate (PEP) to form...; Region: EPSP_synthase; cd01556 443906003731 hinge; other site 443906003732 active site 443906003733 RNA polymerase sigma-70 factor, TIGR02947 family; Region: SigH_actino 443906003734 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 443906003735 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 443906003736 DNA binding residues [nucleotide binding] 443906003737 mycothiol system anti-sigma-R factor; Region: antisig_RsrA; cl15806 443906003738 Acetyltransferase (GNAT) family; Region: Acetyltransf_1; pfam00583 443906003739 alpha-ketoglutarate decarboxylase; Reviewed; Region: kgd; PRK12270 443906003740 2-oxoacid dehydrogenases acyltransferase (catalytic domain); Region: 2-oxoacid_dh; pfam00198 443906003741 Thiamine pyrophosphate (TPP) family, E1 of OGDC-like subfamily, TPP-binding module; composed of proteins similar to the E1 component of the 2-oxoglutarate dehydrogenase multienzyme complex (OGDC). OGDC catalyzes the oxidative decarboxylation of...; Region: TPP_E1_OGDC_like; cd02016 443906003742 TPP-binding site [chemical binding]; other site 443906003743 Transketolase, pyrimidine binding domain; Region: Transket_pyr; pfam02779 443906003744 inosine 5-monophosphate dehydrogenase; Validated; Region: PRK07807 443906003745 TIM barrel proteins share a structurally conserved phosphate binding motif and in general share an eight beta/alpha closed barrel structure. Specific for this family is the conserved phosphate binding site at the edges of strands 7 and 8. The phosphate...; Region: TIM_phosphate_binding; cl17186 443906003746 The CBS domain, named after human CBS, is a small domain originally identified in cystathionine beta-synthase and is subsequently found in a wide range of different proteins. CBS domains usually occur in tandem repeats. They associate to form a so-called...; Region: CBS_pair; cd02205 443906003747 TIM barrel proteins share a structurally conserved phosphate binding motif and in general share an eight beta/alpha closed barrel structure. Specific for this family is the conserved phosphate binding site at the edges of strands 7 and 8. The phosphate...; Region: TIM_phosphate_binding; cl17186 443906003748 phosphate binding site [ion binding]; other site 443906003749 Hemolysins and related proteins containing CBS domains [General function prediction only]; Region: TlyC; COG1253 443906003750 Domain of unknown function DUF21; Region: DUF21; pfam01595 443906003751 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains associated with the CorC_HlyC domain. CorC_HlyC is a transporter associated domain. This small domain is found in Na+/H+ antiporters, in proteins involved in...; Region: CBS_pair_CorC_HlyC_assoc; cd04590 443906003752 Transporter associated domain; Region: CorC_HlyC; smart01091 443906003753 Hemolysins and related proteins containing CBS domains [General function prediction only]; Region: TlyC; COG1253 443906003754 Domain of unknown function DUF21; Region: DUF21; pfam01595 443906003755 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains associated with the CorC_HlyC domain. CorC_HlyC is a transporter associated domain. This small domain is found in Na+/H+ antiporters, in proteins involved in...; Region: CBS_pair_CorC_HlyC_assoc; cd04590 443906003756 NADH:flavin oxidoreductases, Old Yellow Enzyme family [Energy production and conversion]; Region: NemA; COG1902 443906003757 Old yellow enzyme (OYE) YqjM-like FMN binding domain. YqjM is involved in the oxidative stress response of Bacillus subtilis. Like the other OYE members, each monomer of YqjM contains FMN as a non-covalently bound cofactor and uses NADPH as a reducing...; Region: OYE_YqiM_FMN; cd02932 443906003758 active site 443906003759 FMN binding site [chemical binding]; other site 443906003760 substrate binding site [chemical binding]; other site 443906003761 homotetramer interface [polypeptide binding]; other site 443906003762 catalytic residue [active] 443906003763 B.subtilis YXKO protein of unknown function and related proteins. Based on the conservation of the ATP binding site, the substrate binding site and the Mg2+binding site and structural homology this group is a member of the ribokinase-like superfamily; Region: YXKO-related; cd01171 443906003764 YceI-like domain; Region: YceI; pfam04264 443906003765 Domain of unknown function DUF77; Region: DUF77; pfam01910 443906003766 Arabinose efflux permease [Carbohydrate transport and metabolism]; Region: AraJ; COG2814 443906003767 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 443906003768 putative substrate translocation pore; other site 443906003769 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 443906003770 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cl17736 443906003771 active site 443906003772 dimerization interface [polypeptide binding]; other site 443906003773 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 443906003774 DNA binding residues [nucleotide binding] 443906003775 dimerization interface [polypeptide binding]; other site 443906003776 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: COG4585 443906003777 Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase; Region: HATPase_c; pfam02518 443906003778 ATP binding site [chemical binding]; other site 443906003779 Mg2+ binding site [ion binding]; other site 443906003780 G-X-G motif; other site 443906003781 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 443906003782 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 443906003783 active site 443906003784 phosphorylation site [posttranslational modification] 443906003785 intermolecular recognition site; other site 443906003786 dimerization interface [polypeptide binding]; other site 443906003787 Sigma-70, region 4; Region: Sigma70_r4_2; pfam08281 443906003788 DNA binding residues [nucleotide binding] 443906003789 homoserine O-acetyltransferase; Provisional; Region: metX; PRK00175 443906003790 homoserine O-acetyltransferase; Region: homoserO_Ac_trn; TIGR01392 443906003791 O-acetylhomoserine aminocarboxypropyltransferase; Validated; Region: PRK07812 443906003792 CGS_like: Cystathionine gamma-synthase is a PLP dependent enzyme and catalyzes the committed step of methionine biosynthesis. This pathway is unique to microorganisms and plants, rendering the enzyme an attractive target for the development of...; Region: CGS_like; cd00614 443906003793 homodimer interface [polypeptide binding]; other site 443906003794 substrate-cofactor binding pocket; other site 443906003795 pyridoxal 5'-phosphate binding site [chemical binding]; other site 443906003796 catalytic residue [active] 443906003797 Short-chain alcohol dehydrogenase of unknown specificity [General function prediction only]; Region: COG4221 443906003798 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 443906003799 NAD(P) binding site [chemical binding]; other site 443906003800 active site 443906003801 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 443906003802 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 443906003803 integral membrane protein, TerC family; Region: R_switched_Alx; TIGR03718 443906003804 Serine/threonine phosphatases, family 2C, catalytic domain; The protein architecture and deduced catalytic mechanism of PP2C phosphatases are similar to the PP1, PP2A, PP2B family of protein Ser/Thr phosphatases, with which PP2C shares no sequence...; Region: PP2Cc; cd00143 443906003805 active site 443906003806 3-isopropylmalate dehydratase large subunit; Reviewed; Region: PRK00402 443906003807 3-isopropylmalate dehydratase catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate; Region: IPMI; cd01583 443906003808 substrate binding site [chemical binding]; other site 443906003809 ligand binding site [chemical binding]; other site 443906003810 isopropylmalate isomerase small subunit; Provisional; Region: leuD; PRK01641 443906003811 Aconatase-like swivel domain of 3-isopropylmalate dehydratase and related uncharacterized proteins. 3-isopropylmalate dehydratase catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate...; Region: IPMI_Swivel; cd01577 443906003812 substrate binding site [chemical binding]; other site 443906003813 UDP-N-acetylglucosamine 1-carboxyvinyltransferase; Region: murA; TIGR01072 443906003814 UDP-N-acetylglucosamine enolpyruvyl transferase catalyzes enolpyruvyl transfer as part of the first step in the biosynthesis of peptidoglycan, a component of the bacterial cell wall. The reaction is phosphoenolpyruvate + UDP-N-acetyl-D-glucosamine =...; Region: UdpNAET; cd01555 443906003815 hinge; other site 443906003816 active site 443906003817 1-acyl-sn-glycerol-3-phosphate acyltransferase [Lipid metabolism]; Region: PlsC; COG0204 443906003818 Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: AGPAT-like; Region: LPLAT_AGPAT-like; cd07989 443906003819 putative acyl-acceptor binding pocket; other site 443906003820 NAD(P)H-dependent glycerol-3-phosphate dehydrogenase; Validated; Region: gpsA; PRK00094 443906003821 NAD-dependent glycerol-3-phosphate dehydrogenase N-terminus; Region: NAD_Gly3P_dh_N; pfam01210 443906003822 NAD-dependent glycerol-3-phosphate dehydrogenase C-terminus; Region: NAD_Gly3P_dh_C; pfam07479 443906003823 D-alanyl-alanine synthetase A; Reviewed; Region: ddl; PRK01966 443906003824 D-ala D-ala ligase N-terminus; Region: Dala_Dala_lig_N; pfam01820 443906003825 ATP-grasp domain; Region: ATP-grasp_4; cl17255 443906003826 Glycosyltransferases involved in cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WcaA; COG0463 443906003827 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cd00761 443906003828 active site 443906003829 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394 443906003830 Protein of unknown function (DUF3515); Region: DUF3515; pfam12028 443906003831 ThiL (Thiamine-monophosphate kinase) plays a dual role in de novo biosynthesis and in salvage of exogenous thiamine. Thiamine salvage occurs in two steps, with thiamine kinase catalyzing the formation of thiamine phosphate, and ThiL catalyzing the...; Region: ThiL; cd02194 443906003832 ATP binding site [chemical binding]; other site 443906003833 dimerization interface [polypeptide binding]; other site 443906003834 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl17173 443906003835 Conserved hypothetical protein 95; Region: Cons_hypoth95; pfam03602 443906003836 MoxR-like ATPases [General function prediction only]; Region: COG0714 443906003837 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 443906003838 Walker A motif; other site 443906003839 ATP binding site [chemical binding]; other site 443906003840 Walker B motif; other site 443906003841 arginine finger; other site 443906003842 Uncharacterized conserved protein (some members contain a von Willebrand factor type A (vWA) domain) [General function prediction only]; Region: COG1721 443906003843 Protein of unknown function DUF58; Region: DUF58; pfam01882 443906003844 Transglutaminase-like enzymes, putative cysteine proteases [Amino acid transport and metabolism]; Region: COG1305 443906003845 Transglutaminase-like superfamily; Region: Transglut_core; pfam01841 443906003846 ATP-dependent DNA helicase RecG; Provisional; Region: PRK10917 443906003847 RecG_wedge_OBF: A subfamily of OB folds corresponding to the OB fold found in the N-terminal (wedge) domain of Escherichia coli RecG. RecG is a branched-DNA-specific helicase, which catalyzes the interconversion of a DNA replication fork to a...; Region: RecG_wedge_OBF; cd04488 443906003848 ssDNA binding site; other site 443906003849 generic binding surface II; other site 443906003850 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 443906003851 ATP binding site [chemical binding]; other site 443906003852 putative Mg++ binding site [ion binding]; other site 443906003853 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 443906003854 nucleotide binding region [chemical binding]; other site 443906003855 ATP-binding site [chemical binding]; other site 443906003856 phosphopantetheine adenylyltransferase; Provisional; Region: coaD; PRK00168 443906003857 Phosphopantetheine adenylyltransferase; Region: PPAT; cd02163 443906003858 active site 443906003859 (T/H)XGH motif; other site 443906003860 Uncharacterized ACR, COG1399; Region: DUF177; pfam02620 443906003861 50S ribosomal protein L32; Validated; Region: rpmF; PRK01110 443906003862 ribonuclease III; Reviewed; Region: rnc; PRK00102 443906003863 RIBOc. Ribonuclease III C terminal domain. This group consists of eukaryotic, bacterial and archeal ribonuclease III (RNAse III) proteins. RNAse III is a double stranded RNA-specific endonuclease. Prokaryotic RNAse III is important in...; Region: RIBOc; cd00593 443906003864 dimerization interface [polypeptide binding]; other site 443906003865 active site 443906003866 metal binding site [ion binding]; metal-binding site 443906003867 Double-stranded RNA binding motif. Binding is not sequence specific but is highly specific for double stranded RNA. Found in a variety of proteins including dsRNA dependent protein kinase PKR, RNA helicases, Drosophila staufen protein, E. coli RNase III; Region: DSRM; cd00048 443906003868 dsRNA binding site [nucleotide binding]; other site 443906003869 formamidopyrimidine/5-formyluracil/ 5-hydroxymethyluracil DNA glycosylase; Validated; Region: PRK01103 443906003870 N-terminal domain of Escherichia coli Fpg1/MutM and related bacterial DNA glycosylases; Region: EcFpg-like_N; cd08966 443906003871 DNA binding site [nucleotide binding] 443906003872 catalytic residue [active] 443906003873 H2TH interface [polypeptide binding]; other site 443906003874 putative catalytic residues [active] 443906003875 turnover-facilitating residue; other site 443906003876 intercalation triad [nucleotide binding]; other site 443906003877 8OG recognition residue [nucleotide binding]; other site 443906003878 putative reading head residues; other site 443906003879 Formamidopyrimidine-DNA glycosylase H2TH domain; Region: H2TH; pfam06831 443906003880 Zinc finger found in FPG and IleRS; Region: zf-FPG_IleRS; pfam06827 443906003881 Sortase and related acyltransferases [Cell envelope biogenesis, outer membrane]; Region: COG1247 443906003882 ATP-binding cassette domain of barmotin, a member of the SMC protein family; Region: ABC_SMC_barmotin; cd03278 443906003883 Walker A/P-loop; other site 443906003884 ATP binding site [chemical binding]; other site 443906003885 SMC proteins Flexible Hinge Domain; Region: SMC_hinge; pfam06470 443906003886 ATP-binding cassette domain of barmotin, a member of the SMC protein family; Region: ABC_SMC_barmotin; cd03278 443906003887 ABC transporter signature motif; other site 443906003888 Walker B; other site 443906003889 D-loop; other site 443906003890 H-loop/switch region; other site 443906003891 signal recognition particle-docking protein FtsY; Provisional; Region: PRK10416 443906003892 SRP54-type protein, helical bundle domain; Region: SRP54_N; pfam02881 443906003893 The Fer4_NifH superfamily contains a variety of proteins which share a common ATP-binding domain. Functionally, proteins in this superfamily use the energy from hydrolysis of NTP to transfer electron or ion; Region: Fer4_NifH; cl17203 443906003894 signal recognition particle protein; Provisional; Region: PRK10867 443906003895 SRP54-type protein, helical bundle domain; Region: SRP54_N; smart00963 443906003896 The signal recognition particle (SRP) mediates the transport to or across the plasma membrane in bacteria and the endoplasmic reticulum in eukaryotes. SRP recognizes N-terminal sighnal sequences of newly synthesized polypeptides at the ribosome. The...; Region: SRP; cd03115 443906003897 P loop; other site 443906003898 GTP binding site [chemical binding]; other site 443906003899 Signal peptide binding domain; Region: SRP_SPB; pfam02978 443906003900 This domain superfamily is found in a variety of structurally related metalloproteins, including the type I extradiol dioxygenases, glyoxalase I and a group of antibiotic resistance proteins; Region: Glo_EDI_BRP_like; cd06587 443906003901 active site 443906003902 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 443906003903 Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain [Posttranslational modification, protein turnover, chaperones]; Region: DegQ; COG0265 443906003904 Trypsin-like peptidase domain; Region: Trypsin_2; pfam13365 443906003905 carboxylate-amine ligase; Provisional; Region: PRK13517 443906003906 carboxylate-amine ligase, YbdK family; Region: gshA_cyan_rel; TIGR02050 443906003907 30S ribosomal protein S16; Provisional; Region: rpsP; PRK14520 443906003908 Predicted RNA-binding protein (contains KH domain) [General function prediction only]; Region: COG1837 443906003909 jag_K homology RNA-binding domain. The KH domain is found in proteins homologous to the Bacillus subtilis protein Jag, which is associated with SpoIIIJ and is necessary for the third stage of sporulation. The KH motif is a beta-alpha-alpha-beta-beta...; Region: jag_KH; cd02414 443906003910 G-X-X-G motif; other site 443906003911 16S rRNA-processing protein RimM; Provisional; Region: rimM; PRK00122 443906003912 RimM N-terminal domain; Region: RimM; pfam01782 443906003913 tRNA (guanine-N(1)-)-methyltransferase; Reviewed; Region: trmD; PRK00026 443906003914 Methionine Aminopeptidase 1. E.C. 3.4.11.18. Also known as methionyl aminopeptidase and Peptidase M. Catalyzes release of N-terminal amino acids, preferentially methionine, from peptides and arylamides; Region: MetAP1; cd01086 443906003915 active site 443906003916 50S ribosomal protein L19; Provisional; Region: rplS; PRK05338 443906003917 signal peptidase I, bacterial type; Region: sigpep_I_bact; TIGR02227 443906003918 The S26 Type I signal peptidase (SPase; LepB; leader peptidase B; leader peptidase I; EC 3.4.21.89) family members are essential membrane-bound serine proteases that function to cleave the amino-terminal signal peptide extension from proteins that are...; Region: S26_SPase_I; cd06530 443906003919 Catalytic site [active] 443906003920 bacterial Ribonuclease HII-like; Region: RNase_HII_bacteria_HII_like; cd07182 443906003921 RNA/DNA hybrid binding site [nucleotide binding]; other site 443906003922 active site 443906003923 Protein of unknown function (DUF2469); Region: DUF2469; pfam10611 443906003924 hypothetical protein; Reviewed; Region: PRK12497 443906003925 Predicted ATPase with chaperone activity [Posttranslational modification, protein turnover, chaperones]; Region: COG0606 443906003926 Subunit ChlI of Mg-chelatase; Region: ChlI; pfam13541 443906003927 Magnesium chelatase, subunit ChlI; Region: Mg_chelatase; pfam01078 443906003928 Magnesium chelatase, subunit ChlI; Region: Mg_chelatase_2; pfam13335 443906003929 DNA protecting protein DprA; Region: dprA; TIGR00732 443906003930 DNA recombination-mediator protein A; Region: DNA_processg_A; pfam02481 443906003931 site-specific tyrosine recombinase XerC; Reviewed; Region: xerC; PRK00236 443906003932 DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213 443906003933 active site 443906003934 DNA binding site [nucleotide binding] 443906003935 Int/Topo IB signature motif; other site 443906003936 Peptidase family M23; Region: Peptidase_M23; pfam01551 443906003937 D-xylose transporter XylE; Provisional; Region: xylE; PRK10077 443906003938 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 443906003939 putative substrate translocation pore; other site 443906003940 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 443906003941 Ribosomal protein S2 (RPS2), involved in formation of the translation initiation complex, where it might contact the messenger RNA and several components of the ribosome. It has been shown that in Escherichia coli RPS2 is essential for the binding of...; Region: RPS2; cd01425 443906003942 rRNA interaction site [nucleotide binding]; other site 443906003943 S8 interaction site; other site 443906003944 putative laminin-1 binding site; other site 443906003945 elongation factor Ts; Provisional; Region: tsf; PRK09377 443906003946 UBA/TS-N domain; Region: UBA; pfam00627 443906003947 Elongation factor TS; Region: EF_TS; pfam00889 443906003948 Elongation factor TS; Region: EF_TS; pfam00889 443906003949 UMP kinase (UMPK)-Ec, the microbial/chloroplast uridine monophosphate kinase (uridylate kinase) enzyme that catalyzes UMP phosphorylation and plays a key role in pyrimidine nucleotide biosynthesis; regulation of this process is via feed-back control and...; Region: AAK_UMPK-PyrH-Ec; cd04254 443906003950 putative nucleotide binding site [chemical binding]; other site 443906003951 uridine monophosphate binding site [chemical binding]; other site 443906003952 homohexameric interface [polypeptide binding]; other site 443906003953 ribosome recycling factor; Reviewed; Region: frr; PRK00083 443906003954 Ribosome recycling factor (RRF). Ribosome recycling factor dissociates the posttermination complex, composed of the ribosome, deacylated tRNA, and mRNA, after termination of translation. Thus ribosomes are "recycled" and ready for another...; Region: RRF; cd00520 443906003955 hinge region; other site 443906003956 Cytidylyltransferase family; Region: CTP_transf_1; pfam01148 443906003957 CDP-diglyceride synthetase [Lipid metabolism]; Region: CdsA; COG0575 443906003958 DivIVA domain repeat protein; Region: divI1A_rptt_fam; TIGR03543 443906003959 DivIVA domain; Region: DivI1A_domain; TIGR03544 443906003960 DivIVA domain; Region: DivI1A_domain; TIGR03544 443906003961 Lytic Transglycosylase (LT) and Goose Egg White Lysozyme (GEWL) domain. Members include the soluble and insoluble membrane-bound LTs in bacteria, the LTs in bacteriophage lambda, as well as, the eukaryotic "goose-type" lysozymes (GEWL). LTs...; Region: LT_GEWL; cd00254 443906003962 N-acetyl-D-glucosamine binding site [chemical binding]; other site 443906003963 catalytic residue [active] 443906003964 NhaP-type Na+/H+ and K+/H+ antiporters [Inorganic ion transport and metabolism]; Region: NhaP; COG0025 443906003965 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 443906003966 Domain of unknown function DUF20; Region: UPF0118; pfam01594 443906003967 Predicted permease, member of the PurR regulon [General function prediction only]; Region: yhhT; COG0628 443906003968 Thioredoxin domain-containing protein [Posttranslational modification, protein turnover, chaperones]; Region: COG3118 443906003969 Protein Disulfide Oxidoreductases and Other Proteins with a Thioredoxin fold; Region: Thioredoxin_like; cl00388 443906003970 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cl02429 443906003971 glycogen branching enzyme; Provisional; Region: PRK05402 443906003972 N-terminal Early set domain associated with the catalytic domain of prokaryotic glycogen branching enzyme; Region: E_set_GBE_prok_N; cd02855 443906003973 Alpha amylase catalytic domain found in the Glycogen branching enzyme (also called 1,4-alpha-glucan branching enzyme); Region: AmyAc_Glg_BE; cd11322 443906003974 active site 443906003975 catalytic site [active] 443906003976 Alpha amylase, C-terminal all-beta domain; Region: Alpha-amylase_C; pfam02806 443906003977 Domain of unknown function (DUF3416); Region: DUF3416; pfam11896 443906003978 Alpha amylase catalytic domain found in GlgE-like proteins; Region: AmyAc_GlgE_like; cd11344 443906003979 Glycosidases [Carbohydrate transport and metabolism]; Region: AmyA; COG0366 443906003980 active site 443906003981 homodimer interface [polypeptide binding]; other site 443906003982 catalytic site [active] 443906003983 acceptor binding site [chemical binding]; other site 443906003984 This family is most closely related to the oligosaccharide phosphorylase domain family and other unidentified sequences. Oligosaccharide phosphorylase catalyzes the breakdown of oligosaccharides into glucose-1-phosphate units. They are important...; Region: GT1_Glycogen_Phosphorylase_like; cd04299 443906003985 putative homodimer interface [polypeptide binding]; other site 443906003986 putative active site pocket [active] 443906003987 alpha-glucan phosphorylases; Region: more_P_ylases; TIGR02094 443906003988 SGNH_hydrolase, or GDSL_hydrolase, is a diverse family of lipases and esterases. The tertiary fold of the enzyme is substantially different from that of the alpha/beta hydrolase family and unique among all known hydrolases; its active site closely...; Region: SGNH_hydrolase; cl01053 443906003989 SGNH_hydrolase, or GDSL_hydrolase, is a diverse family of lipases and esterases. The tertiary fold of the enzyme is substantially different from that of the alpha/beta hydrolase family and unique among all known hydrolases; its active site closely...; Region: SGNH_hydrolase; cd00229 443906003990 active site 443906003991 catalytic triad [active] 443906003992 glycogen debranching enzyme GlgX; Region: glgX_debranch; TIGR02100 443906003993 N-terminal Early set domain associated with the catalytic domain of Glycogen debranching enzyme and bacterial isoamylase (also called glycogen 6-glucanohydrolase); Region: E_set_GDE_Isoamylase_N; cd02856 443906003994 Alpha amylase catalytic domain found in glycogen debranching enzymes; Region: AmyAc_Glg_debranch; cd11326 443906003995 active site 443906003996 catalytic site [active] 443906003997 Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321 443906003998 cysteine desulfurase NifS; Region: FeS_nifS; TIGR03402 443906003999 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 443906004000 catalytic residue [active] 443906004001 tRNA methyl transferase; Region: tRNA_Me_trans; pfam03054 443906004002 tRNA methyl transferase. This family represents tRNA(5-methylaminomethyl-2-thiouridine)-methyltransferase which is involved in the biosynthesis of the modified nucleoside 5-methylaminomethyl-2-thiouridine present in the wobble position of some tRNAs; Region: tRNA_Me_trans; cd01998 443906004003 NAD-dependent DNA ligase LigA; Validated; Region: ligA; PRK07956 443906004004 NAD+ dependent DNA ligase adenylation domain. DNA ligases catalyze the crucial step of joining the breaks in duplex DNA during DNA replication, repair and recombination, utilizing either ATP or NAD(+) as a cofactor, but using the same basic reaction...; Region: LIGANc; cd00114 443906004005 nucleotide binding pocket [chemical binding]; other site 443906004006 K-X-D-G motif; other site 443906004007 catalytic site [active] 443906004008 NAD-dependent DNA ligase OB-fold domain; Region: DNA_ligase_OB; pfam03120 443906004009 NAD-dependent DNA ligase C4 zinc finger domain; Region: DNA_ligase_ZBD; pfam03119 443906004010 Helix-hairpin-helix motif; Region: HHH; pfam00633 443906004011 Breast Cancer Suppressor Protein (BRCA1), carboxy-terminal domain. The BRCT domain is found within many DNA damage repair and cell cycle checkpoint proteins. The unique diversity of this domain superfamily allows BRCT modules to interact forming homo...; Region: BRCT; cd00027 443906004012 Dimer interface [polypeptide binding]; other site 443906004013 Alpha/beta hydrolase; Region: Abhydrolase_8; pfam06259 443906004014 META domain; Region: META; cl01245 443906004015 aspartyl/glutamyl-tRNA amidotransferase subunit C; Reviewed; Region: gatC; PRK00034 443906004016 Asp-tRNAAsn/Glu-tRNAGln amidotransferase A subunit and related amidases [Translation, ribosomal structure and biogenesis]; Region: GatA; COG0154 443906004017 aspartyl/glutamyl-tRNA amidotransferase subunit A; Reviewed; Region: gatA; PRK00012 443906004018 aspartyl/glutamyl-tRNA amidotransferase subunit B; Validated; Region: gatB; PRK05477 443906004019 GatB/GatE catalytic domain; Region: GatB_N; pfam02934 443906004020 GatB domain; Region: GatB_Yqey; smart00845 443906004021 ATPase components of ABC transporters with duplicated ATPase domains [General function prediction only]; Region: Uup; COG0488 443906004022 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 443906004023 Walker A/P-loop; other site 443906004024 ATP binding site [chemical binding]; other site 443906004025 ABC transporter signature motif; other site 443906004026 Walker B; other site 443906004027 D-loop; other site 443906004028 H-loop/switch region; other site 443906004029 ABC transporter; Region: ABC_tran_2; pfam12848 443906004030 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 443906004031 Uncharacterized membrane-associated protein [Function unknown]; Region: DedA; COG0586 443906004032 SNARE associated Golgi protein; Region: SNARE_assoc; pfam09335 443906004033 long-chain-fatty-acid--CoA ligase; Validated; Region: PRK05605 443906004034 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 443906004035 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 443906004036 acyl-activating enzyme (AAE) consensus motif; other site 443906004037 AMP binding site [chemical binding]; other site 443906004038 active site 443906004039 CoA binding site [chemical binding]; other site 443906004040 START/RHO_alpha_C/PITP/Bet_v1/CoxG/CalC (SRPBCC) ligand-binding domain superfamily; Region: SRPBCC; cd07812 443906004041 hydrophobic ligand binding site; other site 443906004042 Phytoene dehydrogenase and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG1233 443906004043 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450 443906004044 short chain dehydrogenase; Provisional; Region: PRK07109 443906004045 classical (c) SDR, subgroup 3; Region: SDR_c3; cd05360 443906004046 putative NAD(P) binding site [chemical binding]; other site 443906004047 active site 443906004048 long-chain-fatty-acid--CoA ligase; Validated; Region: PRK05605 443906004049 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 443906004050 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 443906004051 acyl-activating enzyme (AAE) consensus motif; other site 443906004052 AMP binding site [chemical binding]; other site 443906004053 active site 443906004054 CoA binding site [chemical binding]; other site 443906004055 short chain dehydrogenase; Provisional; Region: PRK06197 443906004056 retinol dehydrogenase (retinol-DH), Light dependent Protochlorophyllide (Pchlide) OxidoReductase (LPOR) and related proteins, classical (c) SDRs; Region: retinol-DH_like_SDR_c_like; cd05327 443906004057 putative NAD(P) binding site [chemical binding]; other site 443906004058 active site 443906004059 M20 Peptidases with similarity to acetylornithine deacetylases and succinyl-diaminopimelate desuccinylases; Region: M20_ArgE_DapE_like3; cd08013 443906004060 Acetylornithine deacetylase/Succinyl-diaminopimelate desuccinylase and related deacylases [Amino acid transport and metabolism]; Region: ArgE; COG0624 443906004061 metal binding site [ion binding]; metal-binding site 443906004062 putative dimer interface [polypeptide binding]; other site 443906004063 Escherichia coli YfcE and related proteins, metallophosphatase domain; Region: MPP_YfcE; cd00841 443906004064 active site 443906004065 metal binding site [ion binding]; metal-binding site 443906004066 homotetramer interface [polypeptide binding]; other site 443906004067 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl17182 443906004068 Coenzyme A binding pocket [chemical binding]; other site 443906004069 Sulfite oxidase and related enzymes [General function prediction only]; Region: COG2041 443906004070 bacterial and archael members of the sulfite oxidase (SO) family of molybdopterin binding domains. This molybdopterin cofactor (Moco) binding domain is found in a variety of oxidoreductases, main members of this family are nitrate reductase (NR) and...; Region: arch_bact_SO_family_Moco; cd02109 443906004071 Moco binding site; other site 443906004072 metal coordination site [ion binding]; other site 443906004073 Iron-sulfur binding ferredoxin reductase (FNR) proteins combine the FAD and NAD(P) binding regions of FNR with an iron-sulfur binding cluster domain. Ferredoxin-NADP+ (oxido)reductase is an FAD-containing enzyme that catalyzes the reversible electron...; Region: FNR_iron_sulfur_binding_3; cd06217 443906004074 FAD binding pocket [chemical binding]; other site 443906004075 FAD binding motif [chemical binding]; other site 443906004076 phosphate binding motif [ion binding]; other site 443906004077 beta-alpha-beta structure motif; other site 443906004078 NAD binding pocket [chemical binding]; other site 443906004079 Protein of unknown function (DUF1697); Region: DUF1697; pfam08002 443906004080 Uncharacterized protein conserved in bacteria (DUF2236); Region: DUF2236; pfam09995 443906004081 DNA polymerase IV; Validated; Region: PRK03858 443906004082 DNA Polymerase IV/Kappa; Region: PolY_Pol_IV_kappa; cd03586 443906004083 active site 443906004084 DNA binding site [nucleotide binding] 443906004085 Predicted UDP-glucose 6-dehydrogenase [Cell envelope biogenesis, outer membrane]; Region: Ugd; COG1004 443906004086 UDP-glucose/GDP-mannose dehydrogenase family, central domain; Region: UDPG_MGDP_dh; pfam00984 443906004087 UDP binding domain; Region: UDPG_MGDP_dh_C; smart00984 443906004088 malto-oligosyltrehalose trehalohydrolase; Region: trehalose_TreZ; TIGR02402 443906004089 N-terminal Early set domain associated with the catalytic domain of Maltooligosyl trehalose trehalohydrolase (also called Glycosyltrehalose trehalohydrolase) and similar proteins; Region: E_set_MTHase_like_N; cd02853 443906004090 Alpha amylase catalytic domain found in Glycosyltrehalose trehalohydrolase (also called Maltooligosyl trehalose Trehalohydrolase); Region: AmyAc_GTHase; cd11325 443906004091 catalytic site [active] 443906004092 active site 443906004093 Domain of unknown function (DUF3459); Region: DUF3459; pfam11941 443906004094 maltooligosyl trehalose synthase; Provisional; Region: PRK14511 443906004095 Alpha amylase catalytic domain found in maltooligosyl trehalose synthase (MTSase); Region: AmyAc_MTSase; cd11336 443906004096 active site 443906004097 catalytic site [active] 443906004098 glycogen debranching enzyme GlgX; Region: glgX_debranch; TIGR02100 443906004099 N-terminal Early set domain associated with the catalytic domain of Glycogen debranching enzyme and bacterial isoamylase (also called glycogen 6-glucanohydrolase); Region: E_set_GDE_Isoamylase_N; cd02856 443906004100 Alpha amylase catalytic domain found in glycogen debranching enzymes; Region: AmyAc_Glg_debranch; cd11326 443906004101 active site 443906004102 catalytic site [active] 443906004103 Sporulation protein YtfJ (Spore_YtfJ); Region: Spore_YtfJ; cl01596 443906004104 ABC-type cobalt transport system, permease component; Region: ABC_cobalt; cl01943 443906004105 First domain of the ATP-binding cassette component of cobalt transport system; Region: ABC_cobalt_CbiO_domain1; cd03225 443906004106 urea ABC transporter, ATP-binding protein UrtE; Region: urea_trans_UrtE; TIGR03410 443906004107 Walker A/P-loop; other site 443906004108 ATP binding site [chemical binding]; other site 443906004109 Q-loop/lid; other site 443906004110 ABC transporter signature motif; other site 443906004111 Walker B; other site 443906004112 D-loop; other site 443906004113 H-loop/switch region; other site 443906004114 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 443906004115 Walker A/P-loop; other site 443906004116 ATP binding site [chemical binding]; other site 443906004117 Q-loop/lid; other site 443906004118 ABC transporter signature motif; other site 443906004119 Walker B; other site 443906004120 D-loop; other site 443906004121 Cobalt transport protein; Region: CbiQ; cl00463 443906004122 hypothetical protein; Provisional; Region: PRK06547 443906004123 Minimal MMP-like domain found in Acidothermus cellulolyticus hypothetical protein ACEL2062 and similar protein; Region: MMP_ACEL2062; cd12952 443906004124 DEDDh 3'-5' exonuclease domain of oligoribonuclease and similar proteins; Region: Orn; cd06135 443906004125 catalytic site [active] 443906004126 putative active site [active] 443906004127 putative substrate binding site [chemical binding]; other site 443906004128 dimer interface [polypeptide binding]; other site 443906004129 TRX family; composed of two groups: Group I, which includes proteins that exclusively encode a TRX domain; and Group II, which are composed of fusion proteins of TRX and additional domains. Group I TRX is a small ancient protein that alter the redox...; Region: TRX_family; cd02947 443906004130 catalytic residues [active] 443906004131 NAD synthase [Coenzyme metabolism]; Region: NadE; COG0171 443906004132 NAD+ synthase is a homodimer, which catalyzes the final step in de novo nicotinamide adenine dinucleotide (NAD+) biosynthesis, an amide transfer from either ammonia or glutamine to nicotinic acid adenine dinucleotide (NaAD). The conversion of NaAD to NAD...; Region: NAD_synthase; cd00553 443906004133 homodimer interface [polypeptide binding]; other site 443906004134 NAD binding pocket [chemical binding]; other site 443906004135 ATP binding pocket [chemical binding]; other site 443906004136 Mg binding site [ion binding]; other site 443906004137 active-site loop [active] 443906004138 methionine sulfoxide reductase A; Provisional; Region: PRK14054 443906004139 MarR family; Region: MarR_2; cl17246 443906004140 helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347 443906004141 putative ABC transporter ATP-binding protein; Reviewed; Region: PRK11819 443906004142 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 443906004143 Walker A/P-loop; other site 443906004144 ATP binding site [chemical binding]; other site 443906004145 Q-loop/lid; other site 443906004146 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 443906004147 ABC transporter; Region: ABC_tran_2; pfam12848 443906004148 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 443906004149 4-hydroxybenzoyl-CoA thioesterase (4HBT). Catalyzes the final step in the 4-chlorobenzoate degradation pathway in which 4-chlorobenzoate is converted to 4-hydroxybenzoate in certain soil-dwelling bacteria. 4HBT forms a homotetramer with four active sites; Region: 4HBT; cd00586 443906004150 active site 443906004151 Acyl-CoA thioesterase [Lipid metabolism]; Region: TesB; COG1946 443906004152 Thioesterase II (TEII) is thought to regenerate misprimed nonribosomal peptide synthetases (NRPSs) as well as modular polyketide synthases (PKSs) by hydrolyzing acetyl groups bound to the peptidyl carrier protein (PCP) and acyl carrier protein (ACP)...; Region: Thioesterase_II_repeat2; cd03445 443906004153 active site 443906004154 Thioesterase II (TEII) is thought to regenerate misprimed nonribosomal peptide synthetases (NRPSs) as well as modular polyketide synthases (PKSs) by hydrolyzing acetyl groups bound to the peptidyl carrier protein (PCP) and acyl carrier protein (ACP)...; Region: Thioesterase_II_repeat1; cd03444 443906004155 catalytic triad [active] 443906004156 dimer interface [polypeptide binding]; other site 443906004157 Truncated hemoglobins (trHbs) are a family of oxygen-binding heme proteins found in cyanobacteria, eubacteria, unicellular eukaryotes, and plants. The truncated hemoglobins have a characteristic two-over-two alpha helical folding pattern that is distinct...; Region: Trunc_globin; cd00454 443906004158 apolar tunnel; other site 443906004159 heme binding site [chemical binding]; other site 443906004160 dimerization interface [polypeptide binding]; other site 443906004161 Small-conductance mechanosensitive channel [Cell envelope biogenesis, outer membrane]; Region: MscS; COG0668 443906004162 Mechanosensitive ion channel; Region: MS_channel; pfam00924 443906004163 aminopeptidase N, Streptomyces lividans type; Region: pepN_strep_liv; TIGR02412 443906004164 Peptidase M1 family containing Aminopeptidase N; Region: M1_APN_3; cd09602 443906004165 Zn binding site [ion binding]; other site 443906004166 Protein Disulfide Oxidoreductases and Other Proteins with a Thioredoxin fold; Region: Thioredoxin_like; cl00388 443906004167 ribose-5-phosphate isomerase B; Provisional; Region: PRK05571 443906004168 N-terminal domain of the actinomycetal Nei1 and related DNA glycosylases; Region: AcNei1_N; cd08970 443906004169 putative DNA binding site [nucleotide binding]; other site 443906004170 catalytic residue [active] 443906004171 putative H2TH interface [polypeptide binding]; other site 443906004172 putative catalytic residues [active] 443906004173 N-terminal domain of Fpg (formamidopyrimidine-DNA glycosylase, MutM)_Nei (endonuclease VIII) base-excision repair DNA glycosylases; Region: FpgNei_N; cl03119 443906004174 Formamidopyrimidine-DNA glycosylase H2TH domain; Region: H2TH; pfam06831 443906004175 Zinc finger found in FPG and IleRS; Region: zf-FPG_IleRS; pfam06827 443906004176 DPS protein, ferritin-like diiron-binding domain; Region: DPS; cd01043 443906004177 Ferritin-like domain; Region: Ferritin; pfam00210 443906004178 dimerization interface [polypeptide binding]; other site 443906004179 DPS ferroxidase diiron center [ion binding]; other site 443906004180 ion pore; other site 443906004181 trigger factor; Provisional; Region: tig; PRK01490 443906004182 FKBP-type peptidyl-prolyl cis-trans isomerase; Region: FKBP_C; pfam00254 443906004183 Bacterial trigger factor protein (TF) C-terminus; Region: Trigger_C; pfam05698 443906004184 Clp protease; Region: CLP_protease; pfam00574 443906004185 Caseinolytic protease (ClpP) is an ATP-dependent, highly conserved serine protease; Region: S14_ClpP_2; cd07017 443906004186 oligomer interface [polypeptide binding]; other site 443906004187 active site residues [active] 443906004188 ATP-dependent Clp protease proteolytic subunit; Reviewed; Region: PRK12553 443906004189 Caseinolytic protease (ClpP) is an ATP-dependent, highly conserved serine protease; Region: S14_ClpP_2; cd07017 443906004190 oligomer interface [polypeptide binding]; other site 443906004191 active site residues [active] 443906004192 dimethyl sulfone monooxygenase SfnG; Region: LLM_DMSO2_sfnG; TIGR04021 443906004193 Alkanesulfonate monoxygenase is the monoxygenase of a two-component system that catalyzes the conversion of alkanesulfonates to the corresponding aldehyde and sulfite. Alkanesulfonate monoxygenase (SsuD) has an absolute requirement for reduced flavin...; Region: Alkanesulfonate_monoxygenase; cd01094 443906004194 active site 443906004195 dimer interface [polypeptide binding]; other site 443906004196 non-prolyl cis peptide bond; other site 443906004197 insertion regions; other site 443906004198 ATP-dependent protease ATP-binding subunit ClpX; Provisional; Region: clpX; PRK05342 443906004199 ClpX C4-type zinc finger; Region: zf-C4_ClpX; pfam06689 443906004200 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 443906004201 Walker A motif; other site 443906004202 ATP binding site [chemical binding]; other site 443906004203 Walker B motif; other site 443906004204 C-terminal, D2-small domain, of ClpB protein; Region: ClpB_D2-small; smart01086 443906004205 Zn-dependent oligopeptidases [Amino acid transport and metabolism]; Region: Dcp; COG0339 443906004206 Peptidase family M3 dipeptidyl carboxypeptidase (DCP); Region: M3A_DCP; cd06456 443906004207 active site 443906004208 Zn binding site [ion binding]; other site 443906004209 Methyltransferase domain; Region: Methyltransf_31; pfam13847 443906004210 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 443906004211 S-adenosylmethionine binding site [chemical binding]; other site 443906004212 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 443906004213 Coenzyme A binding pocket [chemical binding]; other site 443906004214 valyl-tRNA synthetase; Reviewed; Region: valS; PRK13208 443906004215 nucleotidyl transferase superfamily; Region: nt_trans; cl00015 443906004216 active site 443906004217 HIGH motif; other site 443906004218 nucleotide binding site [chemical binding]; other site 443906004219 nucleotidyl transferase superfamily; Region: nt_trans; cl00015 443906004220 active site 443906004221 KMSKS motif; other site 443906004222 Anticodon-binding domain of valyl tRNA synthetases; Region: Anticodon_Ia_Val; cd07962 443906004223 tRNA binding surface [nucleotide binding]; other site 443906004224 anticodon binding site; other site 443906004225 Phosphoenolpyruvate carboxykinase (PEPCK), a critical gluconeogenic enzyme, catalyzes the first committed step in the diversion of tricarboxylic acid cycle intermediates toward gluconeogenesis. It catalyzes the reversible decarboxylation and...; Region: PEPCK_GTP; cd00819 443906004226 active site 443906004227 substrate-binding site [chemical binding]; other site 443906004228 metal-binding site [ion binding] 443906004229 GTP binding site [chemical binding]; other site 443906004230 transcriptional repressor DicA; Reviewed; Region: PRK09706 443906004231 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 443906004232 non-specific DNA binding site [nucleotide binding]; other site 443906004233 salt bridge; other site 443906004234 sequence-specific DNA binding site [nucleotide binding]; other site 443906004235 Domain of unknown function (DUF955); Region: DUF955; pfam06114 443906004236 ATPase components of various ABC-type transport systems, contain duplicated ATPase [General function prediction only]; Region: COG1123 443906004237 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 443906004238 Walker A/P-loop; other site 443906004239 ATP binding site [chemical binding]; other site 443906004240 Q-loop/lid; other site 443906004241 ABC transporter signature motif; other site 443906004242 Walker B; other site 443906004243 D-loop; other site 443906004244 H-loop/switch region; other site 443906004245 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097 443906004246 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 443906004247 Walker A/P-loop; other site 443906004248 ATP binding site [chemical binding]; other site 443906004249 Q-loop/lid; other site 443906004250 ABC transporter signature motif; other site 443906004251 Walker B; other site 443906004252 D-loop; other site 443906004253 H-loop/switch region; other site 443906004254 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097 443906004255 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppC; COG1173 443906004256 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 443906004257 putative PBP binding loops; other site 443906004258 dimer interface [polypeptide binding]; other site 443906004259 ABC-ATPase subunit interface; other site 443906004260 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppB; COG0601 443906004261 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 443906004262 dimer interface [polypeptide binding]; other site 443906004263 conserved gate region; other site 443906004264 putative PBP binding loops; other site 443906004265 ABC-ATPase subunit interface; other site 443906004266 ABC-type dipeptide transport system, periplasmic component [Amino acid transport and metabolism]; Region: DdpA; COG0747 443906004267 The substrate-binding component of an uncharacterized ABC-type nickel/dipeptide/oligopeptide-like import system contains the type 2 periplasmic binding fold; Region: PBP2_NikA_DppA_OppA_like_15; cd08492 443906004268 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 443906004269 Endoglucanase C-terminal domain/subunit and related proteins [Carbohydrate transport and metabolism]; Region: COG4305 443906004270 Rare lipoprotein A (RlpA)-like double-psi beta-barrel; Region: DPBB_1; pfam03330 443906004271 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 443906004272 S-adenosylmethionine binding site [chemical binding]; other site 443906004273 Isoleucyl-tRNA synthetase [Translation, ribosomal structure and biogenesis]; Region: IleS; COG0060 443906004274 catalytic core domain of isoleucyl-tRNA synthetases; Region: IleRS_core; cd00818 443906004275 HIGH motif; other site 443906004276 catalytic core domain of isoleucyl-tRNA synthetases; Region: IleRS_core; cd00818 443906004277 active site 443906004278 KMSKS motif; other site 443906004279 Anticodon-binding domain of archaeal, bacterial, and eukaryotic cytoplasmic isoleucyl tRNA synthetases; Region: Anticodon_Ia_Ile_ABEc; cd07961 443906004280 tRNA binding surface [nucleotide binding]; other site 443906004281 anticodon binding site; other site 443906004282 Folylpolyglutamate synthase [Coenzyme metabolism]; Region: FolC; COG0285 443906004283 Mur ligase middle domain; Region: Mur_ligase_M; pfam08245 443906004284 Protein of unknown function (DUF4233); Region: DUF4233; pfam14017 443906004285 Nucleoside diphosphate kinase Group I (NDPk_I)-like: NDP kinase domains are present in a large family of structurally and functionally conserved proteins from bacteria to humans that generally catalyze the transfer of gamma-phosphates of a nucleoside...; Region: NDPk_I; cd04413 443906004286 active site 443906004287 multimer interface [polypeptide binding]; other site 443906004288 Vitamin K epoxide reductase family in bacteria; Region: VKOR_5; cd12922 443906004289 putative active site [active] 443906004290 redox center [active] 443906004291 ribonuclease, Rne/Rng family; Region: RNaseEG; TIGR00757 443906004292 S1_RNase_E: RNase E and RNase G, S1-like RNA-binding domain. RNase E is an essential endoribonuclease in the processing and degradation of RNA. In addition to its role in mRNA degradation, RNase E has also been implicated in the processing of rRNA, and...; Region: S1_RNase_E; cd04453 443906004293 homodimer interface [polypeptide binding]; other site 443906004294 oligonucleotide binding site [chemical binding]; other site 443906004295 Protein of unknown function (DUF4031); Region: DUF4031; pfam13223 443906004296 50S ribosomal protein L21; Validated; Region: rplU; PRK05573 443906004297 50S ribosomal protein L27; Validated; Region: rpmA; PRK05435 443906004298 GTPase CgtA; Reviewed; Region: obgE; PRK12296 443906004299 GTP1/OBG; Region: GTP1_OBG; pfam01018 443906004300 Obg GTPase; Region: Obg; cd01898 443906004301 G1 box; other site 443906004302 GTP/Mg2+ binding site [chemical binding]; other site 443906004303 Switch I region; other site 443906004304 G2 box; other site 443906004305 G3 box; other site 443906004306 Switch II region; other site 443906004307 G4 box; other site 443906004308 G5 box; other site 443906004309 Domain of unknown function (DUF1967); Region: DUF1967; pfam09269 443906004310 gamma-glutamyl kinase; Provisional; Region: PRK12314 443906004311 substrate binding site [chemical binding]; other site 443906004312 nucleotide binding site [chemical binding]; other site 443906004313 Gamma-glutamyl phosphate reductase (GPR), aldehyde dehydrogenase families 18 and 19; Region: ALDH_F18-19_ProA-GPR; cd07079 443906004314 gamma-glutamyl phosphate reductase; Region: proA; TIGR00407 443906004315 putative catalytic cysteine [active] 443906004316 nicotinic acid mononucleotide adenylyltransferase; Provisional; Region: nadD; PRK00071 443906004317 Nicotinamide/nicotinate mononucleotide adenylyltransferase; Region: NMNAT; cd02165 443906004318 active site 443906004319 (T/H)XGH motif; other site 443906004320 DNA polymerase III subunits gamma and tau; Provisional; Region: PRK12323 443906004321 iojap-like ribosome-associated protein; Region: iojap_ybeB; TIGR00090 443906004322 Transcription factor zinc-finger; Region: zf-TFIIB; cl01565 443906004323 Nuclease-related domain; Region: NERD; pfam08378 443906004324 SGNH_hydrolase, or GDSL_hydrolase, is a diverse family of lipases and esterases. The tertiary fold of the enzyme is substantially different from that of the alpha/beta hydrolase family and unique among all known hydrolases; its active site closely...; Region: SGNH_hydrolase; cl01053 443906004325 active site 443906004326 catalytic triad [active] 443906004327 oxyanion hole [active] 443906004328 Transcriptional regulators of sugar metabolism [Transcription / Carbohydrate transport and metabolism]; Region: GlpR; COG1349 443906004329 helix_turn_helix, Deoxyribose operon repressor; Region: HTH_DEOR; smart00420 443906004330 DeoR C terminal sensor domain; Region: DeoRC; pfam00455 443906004331 Fructose-1-phosphate kinase and related fructose-6-phosphate kinase (PfkB) [Carbohydrate transport and metabolism]; Region: FruK; COG1105 443906004332 1-phosphofructokinase (FruK), minor 6-phosphofructokinase (pfkB) and related sugar kinases. FruK plays an important role in the predominant pathway for fructose utilisation.This group also contains tagatose-6-phophate kinase, an enzyme of the tagatose...; Region: FruK_PfkB_like; cd01164 443906004333 putative substrate binding site [chemical binding]; other site 443906004334 putative ATP binding site [chemical binding]; other site 443906004335 PTS system 2-O-a-mannosyl-D-glycerate specific transporter subunit IIABC; Provisional; Region: PRK09765 443906004336 PTS_IIA, PTS system, fructose/mannitol specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_fru; cd00211 443906004337 active site 443906004338 phosphorylation site [posttranslational modification] 443906004339 PTS_IIB_fructose: subunit IIB of enzyme II (EII) of the fructose-specific phosphoenolpyruvate:carbohydrate phosphotransferase system (PTS). In this system, EII (also referred to as FruAB) is a fructose-specific permease made up of two proteins (FruA and...; Region: PTS_IIB_fructose; cd05569 443906004340 active site 443906004341 P-loop; other site 443906004342 phosphorylation site [posttranslational modification] 443906004343 Phosphotransferase system, fructose-specific IIC component [Carbohydrate transport and metabolism]; Region: FruA; COG1299 443906004344 Histidine-containing phosphocarrier protein (HPr)-like proteins. HPr is a central component of the bacterial phosphoenolpyruvate sugar phosphotransferase system (PTS). The PTS catalyses the phosphorylation of sugar substrates during their translocation...; Region: PTS-HPr_like; cd00367 443906004345 dimerization domain swap beta strand [polypeptide binding]; other site 443906004346 regulatory protein interface [polypeptide binding]; other site 443906004347 active site 443906004348 regulatory phosphorylation site [posttranslational modification]; other site 443906004349 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 443906004350 NAD(P) binding site [chemical binding]; other site 443906004351 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 443906004352 NAD(P) binding site [chemical binding]; other site 443906004353 Dehydrogenases with different specificities (related to short-chain alcohol dehydrogenases) [Secondary metabolites biosynthesis, transport, and catabolism / General function prediction only]; Region: FabG; COG1028 443906004354 active site 443906004355 DEAD-like helicases superfamily; Region: DEXDc; smart00487 443906004356 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 443906004357 ATP binding site [chemical binding]; other site 443906004358 putative Mg++ binding site [ion binding]; other site 443906004359 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 443906004360 nucleotide binding region [chemical binding]; other site 443906004361 ATP-binding site [chemical binding]; other site 443906004362 Domain of unknown function (DUF3516); Region: DUF3516; pfam12029 443906004363 short chain dehydrogenase; Provisional; Region: PRK06197 443906004364 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 443906004365 NAD(P) binding site [chemical binding]; other site 443906004366 active site 443906004367 histidinol-phosphate aminotransferase; Provisional; Region: PRK03317 443906004368 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 443906004369 pyridoxal 5'-phosphate binding site [chemical binding]; other site 443906004370 homodimer interface [polypeptide binding]; other site 443906004371 catalytic residue [active] 443906004372 Putative lysophospholipase; Region: Hydrolase_4; pfam12146 443906004373 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 443906004374 Prolyl oligopeptidase family; Region: Peptidase_S9; pfam00326 443906004375 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 443906004376 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 443906004377 Major Facilitator Superfamily; Region: MFS_1; pfam07690 443906004378 putative substrate translocation pore; other site 443906004379 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 443906004380 putative NAD(P)H quinone oxidoreductase, PIG3 family; Region: quinone_pig3; TIGR02824 443906004381 PIG3 p53-inducible quinone oxidoreductase; Region: p53_inducible_oxidoreductase; cd05276 443906004382 NAD(P) binding site [chemical binding]; other site 443906004383 Uncharacterized conserved protein [Function unknown]; Region: COG2353 443906004384 Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596 443906004385 Novel bacterial esterase that cleaves esters on halogenated cyclic compounds; Region: Esterase_713_like; cl17303 443906004386 catalytic site [active] 443906004387 alpha/beta hydrolase fold; Region: Abhydrolase_1; pfam00561 443906004388 Bacterial protein of unknown function (DUF939); Region: DUF939; pfam06081 443906004389 DNA polymerase III, alpha subunit [DNA replication, recombination, and repair]; Region: DnaE; COG0587 443906004390 Polymerase and Histidinol Phosphatase domain of alpha-subunit of bacterial polymerase III; Region: PHP_PolIIIA; cd07431 443906004391 active site 443906004392 PHP Thumb interface [polypeptide binding]; other site 443906004393 Polymerase and Histidinol Phosphatase domain; Region: PHP; cl17102 443906004394 DnaE_OBF: A subfamily of OB folds corresponding to the C-terminal OB-fold nucleic acid binding domain of Thermus aquaticus and Escherichia coli type C replicative DNA polymerase III alpha subunit (DnaE). The DNA polymerase holoenzyme of E. coli contains...; Region: DnaE_OBF; cd04485 443906004395 generic binding surface II; other site 443906004396 generic binding surface I; other site 443906004397 glucose-6-phosphate 1-dehydrogenase; Provisional; Region: PRK12853 443906004398 Glucose-6-phosphate dehydrogenase, NAD binding domain; Region: G6PD_N; pfam00479 443906004399 Glucose-6-phosphate dehydrogenase, C-terminal domain; Region: G6PD_C; pfam02781 443906004400 Dienelactone hydrolase and related enzymes [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG0412 443906004401 Transcriptional regulator [Transcription]; Region: LytR; COG1316 443906004402 DNA-binding transcriptional regulator HcaR; Provisional; Region: PRK09906 443906004403 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 443906004404 The C-terminal substrate binding domain of LysR-type transcriptional regulators involved in the catabolism of aromatic compounds and that of other related regulators, contains type 2 periplasmic binding fold; Region: PBP2_LTTR_aromatics_like; cd08414 443906004405 dimerization interface [polypeptide binding]; other site 443906004406 substrate binding pocket [chemical binding]; other site 443906004407 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl17182 443906004408 Nicotinamide mononucleotide transporter; Region: NMN_transporter; pfam04973 443906004409 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 443906004410 Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248 443906004411 active site 443906004412 catalytic tetrad [active] 443906004413 Uncharacterized conserved protein [Function unknown]; Region: COG4850 443906004414 Uncharacterized conserved protein (DUF2183); Region: DUF2183; pfam09949 443906004415 Uncharacterized ACR, COG2135; Region: DUF159; pfam02586 443906004416 ABC-type polar amino acid transport system, ATPase component [Amino acid transport and metabolism]; Region: GlnQ; COG1126 443906004417 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 443906004418 Walker A/P-loop; other site 443906004419 ATP binding site [chemical binding]; other site 443906004420 Q-loop/lid; other site 443906004421 ABC transporter signature motif; other site 443906004422 Walker B; other site 443906004423 D-loop; other site 443906004424 H-loop/switch region; other site 443906004425 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cl00427 443906004426 ABC-type proline/glycine betaine transport systems, permease component [Amino acid transport and metabolism]; Region: OpuBB; COG1174 443906004427 Periplasmic glycine betaine/choline-binding (lipo)protein of an ABC-type transport system (osmoprotectant binding protein) [Cell envelope biogenesis, outer membrane]; Region: OpuBC; COG1732 443906004428 Protein of unknown function (DUF3618); Region: DUF3618; pfam12277 443906004429 Predicted naringenin-chalcone synthase [Secondary metabolites biosynthesis, transport, and catabolism]; Region: BcsA; COG3424 443906004430 Chalcone and stilbene synthases; plant-specific polyketide synthases (PKS) and related enzymes, also called type III PKSs. PKS generate an array of different products, dependent on the nature of the starter molecule. They share a common chemical strategy; Region: CHS_like; cd00831 443906004431 malonyl-CoA binding site [chemical binding]; other site 443906004432 dimer interface [polypeptide binding]; other site 443906004433 active site 443906004434 product binding site; other site 443906004435 hypothetical protein; Provisional; Region: PRK06202 443906004436 ubiquinone biosynthesis hydroxylase family protein; Provisional; Region: PRK07608; cl17314 443906004437 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases [Coenzyme metabolism / Energy production and conversion]; Region: UbiH; COG0654 443906004438 UbiA prenyltransferase family; Region: UbiA; pfam01040 443906004439 putative acetyltransferase; Provisional; Region: PRK03624 443906004440 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 443906004441 Coenzyme A binding pocket [chemical binding]; other site 443906004442 Sortase and related acyltransferases [Cell envelope biogenesis, outer membrane]; Region: COG1247 443906004443 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 443906004444 Coenzyme A binding pocket [chemical binding]; other site 443906004445 cytochrome d terminal oxidase subunit 1; Provisional; Region: PRK15097 443906004446 Bacterial Cytochrome Ubiquinol Oxidase; Region: Bac_Ubq_Cox; pfam01654 443906004447 Cytochrome oxidase subunit II; Region: Cyto_ox_2; pfam02322 443906004448 cytochrome d ubiquinol oxidase subunit 2; Provisional; Region: PRK15003; cl12219 443906004449 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 443906004450 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 443906004451 Walker A/P-loop; other site 443906004452 ATP binding site [chemical binding]; other site 443906004453 Q-loop/lid; other site 443906004454 ABC transporter signature motif; other site 443906004455 Walker B; other site 443906004456 D-loop; other site 443906004457 H-loop/switch region; other site 443906004458 thiol reductant ABC exporter, CydC subunit; Region: CydC; TIGR02868 443906004459 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 443906004460 Walker A/P-loop; other site 443906004461 ATP binding site [chemical binding]; other site 443906004462 Q-loop/lid; other site 443906004463 ABC transporter signature motif; other site 443906004464 Walker B; other site 443906004465 D-loop; other site 443906004466 H-loop/switch region; other site 443906004467 PyridoxaL 5'-Phosphate Dependent Enzymes class IV (PLPDE_IV). This D-amino acid superfamily, one of five classes of PLPDE, consists of branched-chain amino acid aminotransferases (BCAT), D-amino acid transferases (DAAT), and...; Region: PLPDE_IV; cl00224 443906004468 substrate-cofactor binding pocket; other site 443906004469 pyridoxal 5'-phosphate binding site [chemical binding]; other site 443906004470 Anthranilate synthase component I, N terminal region; Region: Anth_synt_I_N; pfam04715 443906004471 aminodeoxychorismate synthase, component I, clade 2; Region: PabB-clade2; TIGR01824 443906004472 chorismate binding enzyme; Region: Chorismate_bind; pfam00425 443906004473 leucyl-tRNA synthetase; Validated; Region: leuS; PRK00390 443906004474 catalytic core domain of leucyl-tRNA synthetases; Region: LeuRS_core; cd00812 443906004475 HIGH motif; other site 443906004476 Leucyl-tRNA synthetase, Domain 2; Region: tRNA-synt_1_2; pfam13603 443906004477 nucleotidyl transferase superfamily; Region: nt_trans; cl00015 443906004478 active site 443906004479 KMSKS motif; other site 443906004480 Anticodon-binding domain of bacterial and eukaryotic mitochondrial leucyl tRNA synthetases; Region: Anticodon_Ia_Leu_BEm; cd07958 443906004481 tRNA binding surface [nucleotide binding]; other site 443906004482 Helix-hairpin-helix motif; Region: HHH_3; pfam12836 443906004483 Predicted membrane metal-binding protein [General function prediction only]; Region: ComEC; COG0658 443906004484 Competence protein; Region: Competence; pfam03772 443906004485 DNA polymerase III, delta subunit [DNA replication, recombination, and repair]; Region: HolA; COG1466 443906004486 30S ribosomal protein S20; Reviewed; Region: rpsT; PRK00239 443906004487 Members of the Nudix hydrolase superfamily catalyze the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+, for their activity and contain a highly...; Region: Nudix_Hydrolase_17; cd04676 443906004488 nudix motif; other site 443906004489 Imidazolonepropionase and related amidohydrolases [Secondary metabolites biosynthesis, transport, and catabolism]; Region: HutI; COG1228 443906004490 Metallo-dependent hydrolases, subgroup C is part of the superfamily of metallo-dependent hydrolases, a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the...; Region: Met_dep_hydrolase_C; cd01309 443906004491 active site 443906004492 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 443906004493 TIGR01777 family protein; Region: yfcH 443906004494 NAD(P) binding site [chemical binding]; other site 443906004495 active site 443906004496 GTP-binding protein LepA; Provisional; Region: PRK05433 443906004497 LepA also known as Elongation Factor 4 (EF4); Region: LepA; cd01890 443906004498 G1 box; other site 443906004499 putative GEF interaction site [polypeptide binding]; other site 443906004500 GTP/Mg2+ binding site [chemical binding]; other site 443906004501 Switch I region; other site 443906004502 G2 box; other site 443906004503 G3 box; other site 443906004504 Switch II region; other site 443906004505 G4 box; other site 443906004506 G5 box; other site 443906004507 lepA_II: This subfamily represents the domain II of LepA, a GTP-binding protein localized in the cytoplasmic membrane. The N-terminal domain of LepA shares regions of homology to translation factors. In terms of interaction with the ribosome, EF-G, EF-Tu...; Region: lepA_II; cd03699 443906004508 lepA_C: This family represents the C-terminal region of LepA, a GTP-binding protein localized in the cytoplasmic membrane. LepA is ubiquitous in Bacteria and Eukaryota (e.g. Saccharomyces cerevisiae GUF1p), but is missing from Archaea. LepA exhibits...; Region: lepA_C; cd03709 443906004509 GTP-binding protein LepA C-terminus; Region: LepA_C; pfam06421 443906004510 Domain of unknown function (DUF1990); Region: DUF1990; pfam09348 443906004511 Haloacid dehalogenase-like hydrolase; Region: HAD_2; pfam13419 443906004512 HAD-hyrolase-like; Region: Hydrolase_like; pfam13242 443906004513 coproporphyrinogen III oxidase; Validated; Region: PRK05628 443906004514 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 443906004515 FeS/SAM binding site; other site 443906004516 This domain superfamily is found in a variety of structurally related metalloproteins, including the type I extradiol dioxygenases, glyoxalase I and a group of antibiotic resistance proteins; Region: Glo_EDI_BRP_like; cd06587 443906004517 active site 443906004518 metal binding site [ion binding]; metal-binding site 443906004519 Tic20-like protein; Region: Tic20; pfam09685 443906004520 heat-inducible transcription repressor; Provisional; Region: hrcA; PRK00082 443906004521 chaperone protein DnaJ; Provisional; Region: PRK14278 443906004522 DnaJ domain or J-domain. DnaJ/Hsp40 (heat shock protein 40) proteins are highly conserved and play crucial roles in protein translation, folding, unfolding, translocation, and degradation. They act primarily by stimulating the ATPase activity of Hsp70s; Region: DnaJ; cd06257 443906004523 HSP70 interaction site [polypeptide binding]; other site 443906004524 Zinc finger domain of DnaJ and HSP40; Region: DnaJ_zf; cd10719 443906004525 Zn binding sites [ion binding]; other site 443906004526 C-terminal substrate binding domain of DnaJ and HSP40; Region: DnaJ_C; cd10747 443906004527 dimer interface [polypeptide binding]; other site 443906004528 16S ribosomal RNA methyltransferase RsmE; Provisional; Region: PRK11713 443906004529 Protein Kinase C Interacting protein related (PKCI): PKCI and related proteins belong to the ubiquitous HIT family of hydrolases that act on alpha-phosphates of ribonucleotides. The members of this subgroup have a conserved HxHxHxx motif (x is a...; Region: PKCI_related; cd01276 443906004530 nucleotide binding site/active site [active] 443906004531 HIT family signature motif; other site 443906004532 catalytic residue [active] 443906004533 Phosphate starvation-inducible protein PhoH, predicted ATPase [Signal transduction mechanisms]; Region: PhoH; COG1702 443906004534 K homology RNA-binding domain, type I. KH binds single-stranded RNA or DNA. It is found in a wide variety of proteins including ribosomal proteins, transcription factors and post-transcriptional modifiers of mRNA. There are two different KH domains that...; Region: KH-I; cl17245 443906004535 nucleic acid binding region [nucleotide binding]; other site 443906004536 G-X-X-G motif; other site 443906004537 PhoH-like protein; Region: PhoH; pfam02562 443906004538 metal-binding heat shock protein; Provisional; Region: PRK00016 443906004539 Domain of unknown function DUF21; Region: DUF21; pfam01595 443906004540 FOG: CBS domain [General function prediction only]; Region: COG0517 443906004541 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains associated with the CorC_HlyC domain. CorC_HlyC is a transporter associated domain. This small domain is found in Na+/H+ antiporters, in proteins involved in...; Region: CBS_pair_CorC_HlyC_assoc; cd04590 443906004542 GTPase Era; Reviewed; Region: era; PRK00089 443906004543 E. coli Ras-like protein (Era) is a multifunctional GTPase; Region: Era; cd04163 443906004544 G1 box; other site 443906004545 GTP/Mg2+ binding site [chemical binding]; other site 443906004546 Switch I region; other site 443906004547 G2 box; other site 443906004548 Switch II region; other site 443906004549 G3 box; other site 443906004550 G4 box; other site 443906004551 G5 box; other site 443906004552 KH domain; Region: KH_2; pfam07650 443906004553 Histidine kinase; Region: HisKA_3; pfam07730 443906004554 Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase; Region: HATPase_c; pfam02518 443906004555 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 443906004556 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 443906004557 active site 443906004558 phosphorylation site [posttranslational modification] 443906004559 intermolecular recognition site; other site 443906004560 dimerization interface [polypeptide binding]; other site 443906004561 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 443906004562 DNA binding residues [nucleotide binding] 443906004563 dimerization interface [polypeptide binding]; other site 443906004564 Putative esterase; Region: Esterase; pfam00756 443906004565 Uncharacterized conserved protein [Function unknown]; Region: COG2898 443906004566 Uncharacterized conserved protein (DUF2156); Region: DUF2156; pfam09924 443906004567 2-isopropylmalate synthase; Validated; Region: PRK03739 443906004568 Mycobacterium tuberculosis LeuA3 and related proteins, N-terminal catalytic TIM barrel domain; Region: DRE_TIM_LeuA; cd07942 443906004569 active site 443906004570 catalytic residues [active] 443906004571 metal binding site [ion binding]; metal-binding site 443906004572 LeuA allosteric (dimerisation) domain; Region: LeuA_dimer; smart00917 443906004573 Predicted membrane protein [Function unknown]; Region: COG2860 443906004574 UPF0126 domain; Region: UPF0126; pfam03458 443906004575 DNA repair protein RecO; Reviewed; Region: recO; PRK00085 443906004576 Recombination protein O N terminal; Region: RecO_N; pfam11967 443906004577 Recombination protein O C terminal; Region: RecO_C; pfam02565 443906004578 Cis (Z)-Isoprenyl Diphosphate Synthases (cis-IPPS); homodimers which catalyze the successive 1'-4 condensation of the isopentenyl diphosphate (IPP) molecule to trans,trans-farnesyl diphosphate (FPP) or to cis,trans-FPP to form long-chain polyprenyl...; Region: CIS_IPPS; cd00475 443906004579 Putative undecaprenyl diphosphate synthase; Region: Prenyltransf; pfam01255 443906004580 catalytic residue [active] 443906004581 putative FPP diphosphate binding site; other site 443906004582 putative FPP binding hydrophobic cleft; other site 443906004583 dimer interface [polypeptide binding]; other site 443906004584 putative IPP diphosphate binding site; other site 443906004585 putative oxidoreductase; Provisional; Region: PRK11579 443906004586 Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408 443906004587 Oxidoreductase family, C-terminal alpha/beta domain; Region: GFO_IDH_MocA_C; pfam02894 443906004588 glycyl-tRNA synthetase; Provisional; Region: PRK04173 443906004589 Class II tRNA amino-acyl synthetase-like catalytic core domain. Class II amino acyl-tRNA synthetases (aaRS) share a common fold and generally attach an amino acid to the 3' OH of ribose of the appropriate tRNA. PheRS is an exception in that it...; Region: class_II_aaRS-like_core; cl00268 443906004590 motif 1; other site 443906004591 Glycyl-tRNA synthetase (GlyRS)-like class II core catalytic domain. GlyRS functions as a homodimer in eukaryotes, archaea and some bacteria and as a heterotetramer in the remainder of prokaryotes. It is responsible for the attachment of glycine to the 3...; Region: GlyRS-like_core; cd00774 443906004592 active site 443906004593 motif 2; other site 443906004594 motif 3; other site 443906004595 GlyRS Glycyl-anticodon binding domain. GlyRS belongs to class II aminoacyl-tRNA synthetases (aaRS). This alignment contains the anticodon binding domain, which is responsible for specificity in tRNA-binding, so that the activated amino acid is...; Region: GlyRS_anticodon; cd00858 443906004596 anticodon binding site; other site 443906004597 YbaK-like. The YbaK family of deacylase domains includes the INS amino acid-editing domain of the bacterial class II prolyl tRNA synthetase (ProRS), and it's trans-acting homologs, YbaK, ProX, and PrdX. The primary function of INS is to hydrolyze...; Region: YbaK_like; cd04332 443906004598 putative deacylase active site [active] 443906004599 Predicted dithiol-disulfide isomerase involved in polyketide biosynthesis [Secondary metabolites biosynthesis, transport, and catabolism]; Region: FrnE; COG2761 443906004600 DsbA family, FrnE subfamily; FrnE is a DsbA-like protein containing a CXXC motif. It is presumed to be a thiol oxidoreductase involved in polyketide biosynthesis, specifically in the production of the aromatic antibiotics frenolicin and nanaomycins; Region: DsbA_FrnE; cd03024 443906004601 catalytic residues [active] 443906004602 putative TIM-barrel protein, nifR3 family; Region: nifR3_yhdG; TIGR00737 443906004603 Dihydrouridine synthase-like (DUS-like) FMN-binding domain. Members of this family catalyze the reduction of the 5,6-double bond of a uridine residue on tRNA. Dihydrouridine modification of tRNA is widely observed in prokaryotes and eukaryotes, and also...; Region: DUS_like_FMN; cd02801 443906004604 FMN binding site [chemical binding]; other site 443906004605 active site 443906004606 catalytic residues [active] 443906004607 substrate binding site [chemical binding]; other site 443906004608 deoxyguanosinetriphosphate triphosphohydrolase-like protein; Provisional; Region: PRK03007 443906004609 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 443906004610 Zn2+ binding site [ion binding]; other site 443906004611 Mg2+ binding site [ion binding]; other site 443906004612 Phosphohydrolase-associated domain; Region: HD_assoc; pfam13286 443906004613 DNA primase; Validated; Region: dnaG; PRK05667 443906004614 CHC2 zinc finger; Region: zf-CHC2; pfam01807 443906004615 DNA primase catalytic core, N-terminal domain; Region: Toprim_N; pfam08275 443906004616 TOPRIM_DnaG_primases: The topoisomerase-primase (TORPIM) nucleotidyl transferase/hydrolase domain found in the active site regions of proteins similar to Escherichia coli DnaG. Primases synthesize RNA primers for the initiation of DNA replication. DnaG...; Region: TOPRIM_DnaG_primases; cd03364 443906004617 active site 443906004618 metal binding site [ion binding]; metal-binding site 443906004619 interdomain interaction site; other site 443906004620 DnaB-helicase binding domain of primase; Region: DnaB_bind; pfam10410 443906004621 ABC-type dipeptide transport system, periplasmic component [Amino acid transport and metabolism]; Region: DdpA; COG0747 443906004622 The substrate-binding component of an uncharacterized ABC-type nickel/dipeptide/oligopeptide-like import system contains the type 2 periplasmic binding fold; Region: PBP2_NikA_DppA_OppA_like_20; cd08519 443906004623 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppB; COG0601 443906004624 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 443906004625 dimer interface [polypeptide binding]; other site 443906004626 conserved gate region; other site 443906004627 putative PBP binding loops; other site 443906004628 ABC-ATPase subunit interface; other site 443906004629 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppC; COG1173 443906004630 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 443906004631 dimer interface [polypeptide binding]; other site 443906004632 conserved gate region; other site 443906004633 ABC-ATPase subunit interface; other site 443906004634 ATPase components of various ABC-type transport systems, contain duplicated ATPase [General function prediction only]; Region: COG1123 443906004635 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 443906004636 Walker A/P-loop; other site 443906004637 ATP binding site [chemical binding]; other site 443906004638 Q-loop/lid; other site 443906004639 ABC transporter signature motif; other site 443906004640 Walker B; other site 443906004641 D-loop; other site 443906004642 H-loop/switch region; other site 443906004643 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097 443906004644 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 443906004645 Walker A/P-loop; other site 443906004646 ATP binding site [chemical binding]; other site 443906004647 Q-loop/lid; other site 443906004648 ABC transporter signature motif; other site 443906004649 Walker B; other site 443906004650 D-loop; other site 443906004651 H-loop/switch region; other site 443906004652 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; pfam08352 443906004653 ABC-type dipeptide/oligopeptide/nickel transport system, ATPase component [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppF; COG1124 443906004654 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 443906004655 Walker A/P-loop; other site 443906004656 ATP binding site [chemical binding]; other site 443906004657 Q-loop/lid; other site 443906004658 ABC transporter signature motif; other site 443906004659 Walker B; other site 443906004660 D-loop; other site 443906004661 H-loop/switch region; other site 443906004662 Putative D-isomer specific 2-hydroxyacid dehydrogenases; Region: 2-Hacid_dh_2; cd12159 443906004663 Phosphoglycerate dehydrogenase and related dehydrogenases [Amino acid transport and metabolism]; Region: SerA; COG0111 443906004664 putative ligand binding site [chemical binding]; other site 443906004665 putative NAD binding site [chemical binding]; other site 443906004666 catalytic site [active] 443906004667 Lactonase, 7-bladed beta-propeller; Region: Lactonase; pfam10282 443906004668 Polypeptide or peptide deformylase; a family of metalloenzymes that catalyzes the removal of the N-terminal formyl group in a growing polypeptide chain following translation initiation during protein synthesis in prokaryotes. These enzymes utilize Fe(II)...; Region: Pep_deformylase; cd00487 443906004669 active site 443906004670 catalytic residues [active] 443906004671 metal binding site [ion binding]; metal-binding site 443906004672 Magnesium transporter NIPA; Region: Mg_trans_NIPA; pfam05653 443906004673 This family is most closely related to the GT1 family of glycosyltransferases. UDP-glucose-diacylglycerol glucosyltransferase (UGDG; also known as 1,2-diacylglycerol 3-glucosyltransferase) catalyzes the transfer of glucose from UDP-glucose to 1; Region: GT1_UGDG_like; cd03817 443906004674 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 443906004675 putative ADP-binding pocket [chemical binding]; other site 443906004676 Predicted acyltransferases [Lipid metabolism]; Region: COG1835 443906004677 glucans biosynthesis protein; Provisional; Region: opgC; PRK03854 443906004678 GDP-fucose synthetase, extended (e) SDRs; Region: GDP_FS_SDR_e; cd05239 443906004679 GDP-4-keto-6-deoxymannose-3, 5-epimerase-4-reductase; Region: PLN02725 443906004680 NADP binding site [chemical binding]; other site 443906004681 active site 443906004682 putative substrate binding site [chemical binding]; other site 443906004683 GDP-D-mannose dehydratase [Cell envelope biogenesis, outer membrane]; Region: Gmd; COG1089 443906004684 GDP-mannose 4,6 dehydratase, extended (e) SDRs; Region: GDP_MD_SDR_e; cd05260 443906004685 NADP-binding site; other site 443906004686 homotetramer interface [polypeptide binding]; other site 443906004687 substrate binding site [chemical binding]; other site 443906004688 homodimer interface [polypeptide binding]; other site 443906004689 active site 443906004690 This family is most closely related to the GT1 family of glycosyltransferases. wbuB in E. coli is involved in the biosynthesis of the O26 O-antigen. It has been proposed to function as an N-acetyl-L-fucosamine (L-FucNAc) transferase; Region: GT1_wbuB_like; cd03794 443906004691 putative glycosyl transferase; Provisional; Region: PRK10307 443906004692 putative acyl transferase; Provisional; Region: PRK10502 443906004693 wcaF-like: This group is composed of the protein product of the E. coli wcaF gene and similar proteins. WcaF is part of the gene cluster responsible for the biosynthesis of the extracellular polysaccharide colanic acid. The wcaF protein is predicted to...; Region: LbH_wcaF_like; cd05825 443906004694 putative trimer interface [polypeptide binding]; other site 443906004695 putative active site [active] 443906004696 putative substrate binding site [chemical binding]; other site 443906004697 putative CoA binding site [chemical binding]; other site 443906004698 Polysaccharide pyruvyl transferase; Region: PS_pyruv_trans; pfam04230 443906004699 Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013 443906004700 putative glycosyl transferase; Provisional; Region: PRK10125 443906004701 putative colanic acid biosynthesis protein; Provisional; Region: wcaD; PRK09953 443906004702 putative glycosyl transferase; Provisional; Region: PRK10063 443906004703 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394 443906004704 active site 443906004705 Serine acetyltransferase (SAT): SAT catalyzes the CoA-dependent acetylation of the side chain hydroxyl group of L-serine to form O-acetylserine, as the first step of a two-step biosynthetic pathway in bacteria and plants leading to the formation of...; Region: LbH_SAT; cd03354 443906004706 trimer interface [polypeptide binding]; other site 443906004707 active site 443906004708 substrate binding site [chemical binding]; other site 443906004709 CoA binding site [chemical binding]; other site 443906004710 Multidrug and toxic compound extrusion family and similar proteins; Region: MATE_like; cl09326 443906004711 exopolysaccharide biosynthesis polyprenyl glycosylphosphotransferase; Region: EPS_sugtrans; TIGR03025 443906004712 Bacterial sugar transferase; Region: Bac_transf; pfam02397 443906004713 Cold-Shock Protein (CSP) contains an S1-like cold-shock domain (CSD) that is found in eukaryotes, prokaryotes, and archaea. CSP's include the major cold-shock proteins CspA and CspB in bacteria and the eukaryotic gene regulatory factor Y-box...; Region: CSP_CDS; cd04458 443906004714 DNA-binding site [nucleotide binding]; DNA binding site 443906004715 RNA-binding motif; other site 443906004716 bifunctional 3'-5' exonuclease/DNA polymerase; Provisional; Region: PRK14975 443906004717 Family A polymerase primarily fills DNA gaps that arise during DNA repair, recombination and replication; Region: DNA_pol_A; cd06444 443906004718 active site 443906004719 DNA binding site [nucleotide binding] 443906004720 catalytic site [active] 443906004721 Protein of unknown function (DUF1684); Region: DUF1684; pfam07920 443906004722 Predicted transcriptional regulators [Transcription]; Region: COG1695 443906004723 Transcriptional regulator PadR-like family; Region: PadR; pfam03551 443906004724 Protein of unknown function (DUF3145); Region: DUF3145; pfam11343 443906004725 beta-ketoacyl-acyl-carrier-protein synthase II; Region: fabF; TIGR03150 443906004726 Beta-ketoacyl-acyl carrier protein (ACP) synthase (KAS), type I and II. KASs are responsible for the elongation steps in fatty acid biosynthesis. KASIII catalyses the initial condensation and KAS I and II catalyze further elongation steps by Claisen...; Region: KAS_I_II; cd00834 443906004727 dimer interface [polypeptide binding]; other site 443906004728 active site 443906004729 acyl carrier protein; Provisional; Region: acpP; PRK00982 443906004730 3-oxoacyl-(acyl carrier protein) synthase III; Reviewed; Region: PRK09352 443906004731 Ketoacyl-acyl carrier protein synthase III (KASIII) initiates the elongation in type II fatty acid synthase systems. It is found in bacteria and plants. Elongation of fatty acids in the type II systems occurs by Claisen condensation of malonyl-acyl...; Region: KAS_III; cd00830 443906004732 dimer interface [polypeptide binding]; other site 443906004733 active site 443906004734 CoA binding pocket [chemical binding]; other site 443906004735 malonyl CoA-acyl carrier protein transacylase; Region: fabD; TIGR00128 443906004736 (acyl-carrier-protein) S-malonyltransferase [Lipid metabolism]; Region: FabD; COG0331 443906004737 PucR C-terminal helix-turn-helix domain; Region: HTH_30; pfam13556 443906004738 pyruvate dehydrogenase subunit E1; Reviewed; Region: aceE; PRK09405 443906004739 Thiamine pyrophosphate (TPP) family, E1 of E. coli PDC-like subfamily, TPP-binding module; composed of proteins similar to the E1 component of the Escherichia coli pyruvate dehydrogenase multienzyme complex (PDC). PDC catalyzes the oxidative...; Region: TPP_E1_EcPDC_like; cd02017 443906004740 dimer interface [polypeptide binding]; other site 443906004741 TPP-binding site [chemical binding]; other site 443906004742 Pyrimidine (PYR) binding domain of thiamine pyrophosphate (TPP)-dependent enzymes; Region: TPP_enzyme_PYR; cl11410 443906004743 Peroxiredoxin [Posttranslational modification, protein turnover, chaperones]; Region: AhpC; COG0450 443906004744 Peroxiredoxin (PRX) family, AhpE-like subfamily; composed of proteins similar to Mycobacterium tuberculosis AhpE. AhpE is described as a 1-cys PRX because of the absence of a resolving cysteine. The structure and sequence of AhpE, however, show greater...; Region: PRX_AhpE_like; cd03018 443906004745 dimer interface [polypeptide binding]; other site 443906004746 catalytic triad [active] 443906004747 tetracycline repressor protein TetR; Provisional; Region: PRK13756 443906004748 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 443906004749 Tetracyclin repressor, C-terminal all-alpha domain; Region: TetR_C; pfam02909 443906004750 ECF-type riboflavin transporter, S component; Region: ECF-ribofla_trS; cl17272 443906004751 Predicted ATPase involved in cell division [Cell division and chromosome partitioning]; Region: FtsE; COG2884 443906004752 First domain of the ATP-binding cassette component of cobalt transport system; Region: ABC_cobalt_CbiO_domain1; cd03225 443906004753 Walker A/P-loop; other site 443906004754 ATP binding site [chemical binding]; other site 443906004755 Q-loop/lid; other site 443906004756 ABC transporter signature motif; other site 443906004757 Walker B; other site 443906004758 D-loop; other site 443906004759 H-loop/switch region; other site 443906004760 ABC-type cobalt transport system, permease component CbiQ and related transporters [Inorganic ion transport and metabolism]; Region: CbiQ; COG0619 443906004761 Uncharacterized conserved protein [Function unknown]; Region: COG0327 443906004762 NIF3 (NGG1p interacting factor 3); Region: NIF3; pfam01784 443906004763 Zn-ribbon protein, possibly nucleic acid-binding [General function prediction only]; Region: COG1579 443906004764 Putative zinc ribbon domain; Region: DUF164; pfam02591 443906004765 Transcriptional regulator/sugar kinase [Transcription / Carbohydrate transport and metabolism]; Region: NagC; COG1940 443906004766 Ketopantoate hydroxymethyltransferase (KPHMT) is the first enzyme in the pantothenate biosynthesis pathway. Ketopantoate hydroxymethyltransferase (KPHMT) catalyzes the first committed step in the biosynthesis of pantothenate (vitamin B5), which is a...; Region: KPHMT-like; cd06557 443906004767 oligomerization interface [polypeptide binding]; other site 443906004768 active site 443906004769 metal binding site [ion binding]; metal-binding site 443906004770 Glutamine synthetase [Amino acid transport and metabolism]; Region: GlnA; COG0174 443906004771 Glutamine synthetase, beta-Grasp domain; Region: Gln-synt_N; pfam03951 443906004772 Glutamine synthetase, catalytic domain; Region: Gln-synt_C; pfam00120 443906004773 bifunctional glutamine-synthetase adenylyltransferase/deadenyltransferase; Provisional; Region: PRK14109 443906004774 Nucleotidyltransferase (NT) domain of Escherichia coli adenylyltransferase (GlnE), Escherichia coli uridylyl transferase (GlnD), and similar proteins; Region: NT_GlnE_GlnD_like; cd05401 443906004775 metal binding triad; other site 443906004776 GlnD PII-uridylyltransferase; Region: GlnD_UR_UTase; pfam08335 443906004777 Nucleotidyltransferase (NT) domain of Escherichia coli adenylyltransferase (GlnE), Escherichia coli uridylyl transferase (GlnD), and similar proteins; Region: NT_GlnE_GlnD_like; cd05401 443906004778 metal binding triad; other site 443906004779 GlnD PII-uridylyltransferase; Region: GlnD_UR_UTase; pfam08335 443906004780 glutamine synthetase, type I; Region: GlnA; TIGR00653 443906004781 Glutamine synthetase, beta-Grasp domain; Region: Gln-synt_N; pfam03951 443906004782 Glutamine synthetase, catalytic domain; Region: Gln-synt_C; pfam00120 443906004783 RDD family; Region: RDD; pfam06271 443906004784 DnaJ molecular chaperone homology domain; Region: DnaJ; smart00271 443906004785 HSP70 interaction site [polypeptide binding]; other site 443906004786 Domain of unknown function (DUF4191); Region: DUF4191; pfam13829 443906004787 Protein Kinases, catalytic domain; Region: PKc_like; cl09925 443906004788 active site 443906004789 ATP binding site [chemical binding]; other site 443906004790 substrate binding site [chemical binding]; other site 443906004791 Lipoyl domain of the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases. 2-oxo acid dehydrogenase multienzyme complexes, like pyruvate dehydrogenase (PDH), 2-oxoglutarate dehydrogenase (OGDH) and branched-chain 2-oxo acid...; Region: lipoyl_domain; cd06849 443906004792 E3 interaction surface; other site 443906004793 lipoyl attachment site [posttranslational modification]; other site 443906004794 e3 binding domain; Region: E3_binding; pfam02817 443906004795 dihydrolipoamide acetyltransferase; Reviewed; Region: PRK11857 443906004796 2-oxoacid dehydrogenases acyltransferase (catalytic domain); Region: 2-oxoacid_dh; pfam00198 443906004797 dihydrolipoamide dehydrogenase; Reviewed; Region: PRK06416 443906004798 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 443906004799 Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain; Region: Pyr_redox_dim; pfam02852 443906004800 Cytosol aminopeptidase family, N-terminal and catalytic domains. Family M17 contains zinc- and manganese-dependent exopeptidases ( EC 3.4.11.1), including leucine aminopeptidase. They catalyze removal of amino acids from the N-terminus of a protein and...; Region: Peptidase_M17; cd00433 443906004801 interface (dimer of trimers) [polypeptide binding]; other site 443906004802 multifunctional aminopeptidase A; Provisional; Region: PRK00913 443906004803 Substrate-binding/catalytic site; other site 443906004804 Zn-binding sites [ion binding]; other site 443906004805 PAC2 family; Region: PAC2; pfam09754 443906004806 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 443906004807 putative substrate translocation pore; other site 443906004808 Major Facilitator Superfamily; Region: MFS_1; pfam07690 443906004809 RNA polymerase sigma factor SigB; Reviewed; Region: PRK07921 443906004810 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 443906004811 Sigma-70 region 3; Region: Sigma70_r3; pfam04539 443906004812 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 443906004813 DNA binding residues [nucleotide binding] 443906004814 Mur ligase middle domain; Region: Mur_ligase_M; pfam08245 443906004815 Domain of unknown function (DUF1727); Region: DUF1727; pfam08353 443906004816 Type 1 glutamine amidotransferase (GATase1)-like domain; Region: GAT_1; cl00020 443906004817 conserved cys residue [active] 443906004818 DNA topoisomerase IV subunit B; Reviewed; Region: PRK05559 443906004819 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 443906004820 ATP binding site [chemical binding]; other site 443906004821 Mg2+ binding site [ion binding]; other site 443906004822 G-X-G motif; other site 443906004823 TopoIIA_Trans_DNA_gyrase: Transducer domain, having a ribosomal S5 domain 2-like fold, of the type found in proteins of the type IIA family of DNA topoisomerases similar to the B subunits of E. coli DNA gyrase and E. coli Topoisomerase IV which are; Region: TopoII_Trans_DNA_gyrase; cd00822 443906004824 anchoring element; other site 443906004825 dimer interface [polypeptide binding]; other site 443906004826 ATP binding site [chemical binding]; other site 443906004827 Topoisomerase-primase domain. This is a nucleotidyl transferase/hydrolase domain found in type IA, type IIA and type IIB topoisomerases, bacterial DnaG-type primases, small primase-like proteins from bacteria and archaea, OLD family nucleases from...; Region: TOPRIM; cl00718 443906004828 active site 443906004829 metal binding site [ion binding]; metal-binding site 443906004830 DNA gyrase B subunit, carboxyl terminus; Region: DNA_gyraseB_C; pfam00986 443906004831 DNA topoisomerase IV subunit A; Validated; Region: PRK05561 443906004832 DNA Topoisomerase, subtype IIA; domain A'; bacterial DNA topoisomerase IV (C subunit, ParC), bacterial DNA gyrases (A subunit, GyrA),mammalian DNA toposiomerases II. DNA topoisomerases are essential enzymes that regulate the conformational changes...; Region: TOP4c; cd00187 443906004833 CAP-like domain; other site 443906004834 active site 443906004835 primary dimer interface [polypeptide binding]; other site 443906004836 Type I phosphodiesterase / nucleotide pyrophosphatase; Region: Phosphodiest; pfam01663 443906004837 Molybdopterin-Binding (MopB) domain of the MopB superfamily of proteins, a large, diverse, heterogeneous superfamily of enzymes that, in general, bind molybdopterin as a cofactor. The MopB domain is found in a wide variety of molybdenum- and...; Region: Molybdopterin-Binding; cl09928 443906004838 Protein of unknown function (DUF3071); Region: DUF3071; pfam11268 443906004839 Domain of unknown function (DUF4193); Region: DUF4193; pfam13834 443906004840 Protein of unknown function (DUF3093); Region: DUF3093; pfam11292 443906004841 Trimeric dUTP diphosphatases; Region: trimeric_dUTPase; cd07557 443906004842 trimer interface [polypeptide binding]; other site 443906004843 active site 443906004844 Protein of unknown function (DUF3710); Region: DUF3710; pfam12502 443906004845 Protein of unknown function (DUF3159); Region: DUF3159; pfam11361 443906004846 aconitate hydratase; Validated; Region: PRK09277 443906004847 Aconitase catalytic domain; Aconitase catalyzes the reversible isomerization of citrate and isocitrate as part of the TCA cycle; Region: Aconitase; cl00285 443906004848 substrate binding site [chemical binding]; other site 443906004849 ligand binding site [chemical binding]; other site 443906004850 Aconitase A swivel domain. This is the major form of the TCA cycle enzyme aconitate hydratase, also known as aconitase and citrate hydro-lyase. It includes bacterial and archaeal aconitase A, and the eukaryotic cytosolic form of aconitase. This group...; Region: AcnA_IRP_Swivel; cd01580 443906004851 substrate binding site [chemical binding]; other site 443906004852 1-deoxy-D-xylulose-5-phosphate synthase; Provisional; Region: PRK05444 443906004853 Thiamine pyrophosphate (TPP) family, DXS subfamily, TPP-binding module; 1-Deoxy-D-xylulose-5-phosphate synthase (DXS) is a regulatory enzyme of the mevalonate-independent pathway involved in terpenoid biosynthesis. Terpeniods are plant natural products...; Region: TPP_DXS; cd02007 443906004854 TPP-binding site; other site 443906004855 Pyrimidine (PYR) binding domain of 1-deoxy-D-xylulose-5-phosphate synthase (DXS), transketolase (TK), and related proteins; Region: TPP_PYR_DXS_TK_like; cd07033 443906004856 PYR/PP interface [polypeptide binding]; other site 443906004857 dimer interface [polypeptide binding]; other site 443906004858 TPP binding site [chemical binding]; other site 443906004859 Transketolase, C-terminal domain; Region: Transketolase_C; pfam02780 443906004860 Enoyl-CoA hydratase/carnithine racemase [Lipid metabolism]; Region: CaiD; COG1024 443906004861 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 443906004862 substrate binding site [chemical binding]; other site 443906004863 oxyanion hole (OAH) forming residues; other site 443906004864 trimer interface [polypeptide binding]; other site 443906004865 3-hydroxybutyryl-CoA dehydrogenase; Region: PLN02545 443906004866 3-hydroxyacyl-CoA dehydrogenase, NAD binding domain; Region: 3HCDH_N; pfam02737 443906004867 3-hydroxyacyl-CoA dehydrogenase, C-terminal domain; Region: 3HCDH; pfam00725 443906004868 acetyl-CoA acetyltransferases; Region: AcCoA-C-Actrans; TIGR01930 443906004869 Thiolase are ubiquitous enzymes that catalyze the reversible thiolytic cleavage of 3-ketoacyl-CoA into acyl-CoA and acetyl-CoA, a 2-step reaction involving a covalent intermediate formed with a catalytic cysteine. They are found in prokaryotes and...; Region: thiolase; cd00751 443906004870 dimer interface [polypeptide binding]; other site 443906004871 active site 443906004872 Ribonuclease D [Translation, ribosomal structure and biogenesis]; Region: Rnd; COG0349 443906004873 DEDDy 3'-5' exonuclease domain of Ribonuclease D and similar proteins; Region: RNaseD_exo; cd06142 443906004874 catalytic site [active] 443906004875 putative active site [active] 443906004876 putative substrate binding site [chemical binding]; other site 443906004877 HRDC domain; Region: HRDC; pfam00570 443906004878 Protein of unknown function (DUF3000); Region: DUF3000; pfam11452 443906004879 RibD C-terminal domain; Region: RibD_C; cl17279 443906004880 Pyrimidine reductase, riboflavin biosynthesis [Coenzyme metabolism]; Region: RibD; COG1985 443906004881 Fe-S metabolism associated domain; Region: SufE; cl00951 443906004882 Rhodanese-related sulfurtransferase [Inorganic ion transport and metabolism]; Region: SseA; COG2897 443906004883 Thiosulfate sulfurtransferase (TST), N-terminal, inactive domain. TST contains 2 copies of the Rhodanese Homology Domain; this is the 1st repeat, which does not contain the catalytically active Cys residue. The role of the 1st repeat is uncertain, but it...; Region: TST_Repeat_1; cd01448 443906004884 active site residue [active] 443906004885 Thiosulfate sulfurtransferase (TST), C-terminal, catalytic domain. TST contains 2 copies of the Rhodanese Homology Domain; this is the second repeat. Only the second repeat contains the catalytically active Cys residue; Region: TST_Repeat_2; cd01449 443906004886 active site residue [active] 443906004887 AFG1-like ATPase; Region: AFG1_ATPase; pfam03969 443906004888 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cl17189 443906004889 Ammonia permease [Inorganic ion transport and metabolism]; Region: AmtB; COG0004 443906004890 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 443906004891 Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248 443906004892 active site 443906004893 catalytic tetrad [active] 443906004894 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl17173 443906004895 N5-glutamine S-adenosyl-L-methionine-dependent methyltransferase; Provisional; Region: PRK09328 443906004896 Glycosyl hydrolase family 10; Region: Glyco_hydro_10; cl01495 443906004897 Carbohydrate binding domain; Region: CBM_4_9; pfam02018 443906004898 Glycosyl hydrolase family 10; Region: Glyco_hydro_10; pfam00331 443906004899 HYR domain; Region: HYR; pfam02494 443906004900 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 443906004901 Predicted nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: COG0702 443906004902 NAD(P) binding site [chemical binding]; other site 443906004903 active site 443906004904 Nudix hydrolase is a superfamily of enzymes found in all three kingdoms of life, and it catalyzes the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+...; Region: Nudix_Hydrolase; cl00447 443906004905 nudix motif; other site 443906004906 Dipeptidyl aminopeptidases/acylaminoacyl-peptidases [Amino acid transport and metabolism]; Region: DAP2; COG1506 443906004907 Prolyl oligopeptidase family; Region: Peptidase_S9; pfam00326 443906004908 short chain dehydrogenase; Provisional; Region: PRK07806 443906004909 NAD(P) binding site [chemical binding]; other site 443906004910 active site 443906004911 Glycerophosphoryl diester phosphodiesterase [Energy production and conversion]; Region: UgpQ; COG0584 443906004912 Glycerophosphodiester phosphodiesterase domain of Streptomyces coelicolor cytoplasmic phosphodiesterases UgpQ2 and similar proteins; Region: GDPD_cytoplasmic_ScUgpQ2_like; cd08561 443906004913 putative active site [active] 443906004914 catalytic site [active] 443906004915 putative metal binding site [ion binding]; other site 443906004916 Domain of unknown function (DUF4109); Region: DUF4109; pfam13397 443906004917 Apolipoprotein N-acyl transferase (class 9 nitrilases); Region: ALP_N-acyl_transferase; cd07571 443906004918 putative active site [active] 443906004919 catalytic triad [active] 443906004920 putative dimer interface [polypeptide binding]; other site 443906004921 DEAD-like helicases superfamily; Region: DEXDc; smart00487 443906004922 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 443906004923 ATP binding site [chemical binding]; other site 443906004924 putative Mg++ binding site [ion binding]; other site 443906004925 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 443906004926 nucleotide binding region [chemical binding]; other site 443906004927 ATP-binding site [chemical binding]; other site 443906004928 DSHCT (NUC185) domain; Region: DSHCT; pfam08148 443906004929 Sec-independent protein translocase protein (TatC); Region: TatC; pfam00902 443906004930 mttA/Hcf106 family; Region: MttA_Hcf106; pfam02416 443906004931 Predicted transcriptional regulator [Transcription]; Region: COG2378 443906004932 FeoC like transcriptional regulator; Region: FeoC; cl17677 443906004933 WYL domain; Region: WYL; pfam13280 443906004934 Predicted transcriptional regulator [Transcription]; Region: COG2378 443906004935 WYL domain; Region: WYL; pfam13280 443906004936 FKBP-type peptidyl-prolyl cis-trans isomerase; Region: FKBP_C; pfam00254 443906004937 tRNA(1-methyladenosine) methyltransferase and related methyltransferases [Translation, ribosomal structure and biogenesis]; Region: GCD14; COG2519 443906004938 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 443906004939 S-adenosylmethionine binding site [chemical binding]; other site 443906004940 beta-phosphoglucomutase family hydrolase; Region: PGMB-YQAB-SF; TIGR02009 443906004941 haloacid dehalogenase-like hydrolase; Region: HAD; cl17202 443906004942 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 443906004943 motif II; other site 443906004944 PAC2 family; Region: PAC2; pfam09754 443906004945 nucleotidyl transferase superfamily; Region: nt_trans; cl00015 443906004946 cysteinyl-tRNA synthetase; Provisional; Region: PRK12418 443906004947 active site 443906004948 HIGH motif; other site 443906004949 nucleotide binding site [chemical binding]; other site 443906004950 nucleotidyl transferase superfamily; Region: nt_trans; cl00015 443906004951 active site 443906004952 KMSKS motif; other site 443906004953 undecaprenyl pyrophosphate phosphatase; Reviewed; Region: PRK12554 443906004954 hypothetical protein; Provisional; Region: PRK07906 443906004955 M20 Peptidase, carboxypeptidase yscS-like; Region: M20_yscS_like; cd05675 443906004956 putative metal binding site [ion binding]; other site 443906004957 Mg2+ and Co2+ transporters [Inorganic ion transport and metabolism]; Region: CorA; COG0598 443906004958 Mycobacterium tuberculosis CorA-like subfamily; Region: MtCorA-like; cd12830 443906004959 oligomer interface [polypeptide binding]; other site 443906004960 metal binding site [ion binding]; metal-binding site 443906004961 metal binding site [ion binding]; metal-binding site 443906004962 putative Cl binding site [ion binding]; other site 443906004963 basic sphincter; other site 443906004964 hydrophobic gate; other site 443906004965 periplasmic entrance; other site 443906004966 Nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: WcaG; COG0451 443906004967 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 443906004968 NAD(P) binding site [chemical binding]; other site 443906004969 active site 443906004970 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 443906004971 DnaJ domain or J-domain. DnaJ/Hsp40 (heat shock protein 40) proteins are highly conserved and play crucial roles in protein translation, folding, unfolding, translocation, and degradation. They act primarily by stimulating the ATPase activity of Hsp70s; Region: DnaJ; cd06257 443906004972 HSP70 interaction site [polypeptide binding]; other site 443906004973 ABC-type proline/glycine betaine transport systems, permease component [Amino acid transport and metabolism]; Region: OpuBB; COG1174 443906004974 ABC-type proline/glycine betaine transport systems, ATPase components [Amino acid transport and metabolism]; Region: OpuBA; COG1125 443906004975 ATP-binding cassette domain of the osmoprotectant transporter; Region: ABC_OpuCA_Osmoprotection; cd03295 443906004976 Walker A/P-loop; other site 443906004977 ATP binding site [chemical binding]; other site 443906004978 Q-loop/lid; other site 443906004979 ABC transporter signature motif; other site 443906004980 Walker B; other site 443906004981 D-loop; other site 443906004982 H-loop/switch region; other site 443906004983 The CBS domain, named after human CBS, is a small domain originally identified in cystathionine beta-synthase and is subsequently found in a wide range of different proteins. CBS domains usually occur in tandem repeats. They associate to form a so-called...; Region: CBS_pair; cd02205 443906004984 ABC-type proline/glycine betaine transport systems, permease component [Amino acid transport and metabolism]; Region: OpuBB; COG1174 443906004985 Substrate binding domain of ABC-type glycine betaine transport system; Region: OpuAC; pfam04069 443906004986 DNA or RNA helicases of superfamily II [Transcription / DNA replication, recombination, and repair]; Region: SSL2; COG1061 443906004987 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 443906004988 ATP binding site [chemical binding]; other site 443906004989 putative Mg++ binding site [ion binding]; other site 443906004990 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 443906004991 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 443906004992 active site 443906004993 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 443906004994 Predicted ring-cleavage extradiol dioxygenase [General function prediction only]; Region: COG2514 443906004995 This conserved domain belongs to a superfamily including the bleomycin resistance protein, glyoxalase I, and type I ring-cleaving dioxygenases; Region: Glo_EDI_BRP_like_12; cd07255 443906004996 putative metal binding site [ion binding]; other site 443906004997 This domain superfamily is found in a variety of structurally related metalloproteins, including the type I extradiol dioxygenases, glyoxalase I and a group of antibiotic resistance proteins; Region: Glo_EDI_BRP_like; cd06587 443906004998 active site 443906004999 metal binding site [ion binding]; metal-binding site 443906005000 Members of the SGNH-hydrolase superfamily, a diverse family of lipases and esterases. The tertiary fold of the enzyme is substantially different from that of the alpha/beta hydrolase family and unique among all known hydrolases; its active site closely...; Region: SGNH_hydrolase_like_1; cd01832 443906005001 active site 443906005002 catalytic triad [active] 443906005003 oxyanion hole [active] 443906005004 D-alanyl-D-alanine carboxypeptidase; Region: Peptidase_S11; pfam00768 443906005005 Beta-lactamase enzyme family; Region: Beta-lactamase2; cl17872 443906005006 rRNA methylases [Translation, ribosomal structure and biogenesis]; Region: SpoU; COG0566 443906005007 SpoU rRNA Methylase family; Region: SpoU_methylase; pfam00588 443906005008 NAD-dependent deacetylase; Provisional; Region: PRK05333 443906005009 SIR2 superfamily of proteins includes silent information regulator 2 (Sir2) enzymes which catalyze NAD+-dependent protein/histone deacetylation, where the acetyl group from the lysine epsilon-amino group is transferred to the ADP-ribose moiety of NAD+; Region: SIR2; cl00195 443906005010 Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067 443906005011 catalytic core [active] 443906005012 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 443906005013 This family is most closely related to the GT1 family of glycosyltransferases. mtfB (mannosyltransferase B) in E. coli has been shown to direct the growth of the O9-specific polysaccharide chain. It transfers two mannoses into the position 3 of the...; Region: GT1_mtfB_like; cd03809 443906005014 Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596 443906005015 TAP-like protein; Region: Abhydrolase_4; pfam08386 443906005016 trehalose synthase; Region: treS_nterm; TIGR02456 443906005017 Alpha amylase catalytic domain found in Trehalose synthetase; Region: AmyAc_TreS; cd11334 443906005018 active site 443906005019 catalytic site [active] 443906005020 Alpha amylase, C-terminal all-beta domain; Region: Alpha-amylase_C; pfam02806 443906005021 DNA polymerase III, epsilon subunit and related 3'-5' exonucleases [DNA replication, recombination, and repair]; Region: DnaQ; COG0847 443906005022 DEDDh 3'-5' exonuclease domain family; Region: DEDDh; cd06127 443906005023 active site 443906005024 catalytic site [active] 443906005025 substrate binding site [chemical binding]; other site 443906005026 50S ribosomal protein L31 type B; Reviewed; Region: rpmE2; PRK01678 443906005027 ABC-type cobalamin/Fe3+-siderophores transport systems, ATPase components [Inorganic ion transport and metabolism / Coenzyme metabolism]; Region: FepC; COG1120 443906005028 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 443906005029 Walker A/P-loop; other site 443906005030 ATP binding site [chemical binding]; other site 443906005031 Q-loop/lid; other site 443906005032 ABC transporter signature motif; other site 443906005033 Walker B; other site 443906005034 D-loop; other site 443906005035 H-loop/switch region; other site 443906005036 glycogen synthase, Corynebacterium family; Region: glgA_Coryne; TIGR02149 443906005037 This family is most closely related to the GT1 family of glycosyltransferases and named after YqgM in Bacillus licheniformis about which little is known. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to...; Region: GT1_YqgM_like; cd03801 443906005038 glucose-1-phosphate adenylyltransferase; Provisional; Region: glgC; PRK00844 443906005039 ADP-glucose pyrophosphorylase is involved in the biosynthesis of glycogen or starch; Region: ADP_Glucose_PP; cd02508 443906005040 ligand binding site; other site 443906005041 oligomer interface; other site 443906005042 Glucose-1-phosphate adenylyltransferase, C-terminal Left-handed parallel beta helix (LbH) domain: Glucose-1-phosphate adenylyltransferase is also known as ADP-glucose synthase or ADP-glucose pyrophosphorylase. It catalyzes the first committed and...; Region: LbH_G1P_AT_C; cd04651 443906005043 dimer interface [polypeptide binding]; other site 443906005044 N-terminal domain interface [polypeptide binding]; other site 443906005045 sulfate 1 binding site; other site 443906005046 Phosphoserine phosphatase [Amino acid transport and metabolism]; Region: SerB; COG0560 443906005047 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 443906005048 motif II; other site 443906005049 Phosphotransferase enzyme family; Region: APH; pfam01636 443906005050 Aminoglycoside 3'-phosphotransferase (APH) and Choline Kinase (ChoK) family. The APH/ChoK family is part of a larger superfamily that includes the catalytic domains of other kinases, such as the typical serine/threonine/tyrosine protein kinases (PKs)...; Region: APH_ChoK_like; cl17270 443906005051 active site 443906005052 ATP binding site [chemical binding]; other site 443906005053 substrate binding site [chemical binding]; other site 443906005054 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 443906005055 3-oxoacyl-(acyl-carrier-protein) reductase; Region: 3oxo_ACP_reduc; TIGR01830 443906005056 NAD(P) binding site [chemical binding]; other site 443906005057 active site 443906005058 Protein of unknown function (DUF3099); Region: DUF3099; pfam11298 443906005059 SURF1 superfamily. Surf1/Shy1 has been implicated in the posttranslational steps of the biogenesis of the mitochondrially-encoded Cox1 subunit of cytochrome c oxidase (complex IV). Cytochrome c oxidase (complex IV), the terminal electron-transferring...; Region: SURF1; cd06662 443906005060 ATPase components of ABC transporters with duplicated ATPase domains [General function prediction only]; Region: Uup; COG0488 443906005061 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 443906005062 Walker A/P-loop; other site 443906005063 ATP binding site [chemical binding]; other site 443906005064 Q-loop/lid; other site 443906005065 ABC transporter signature motif; other site 443906005066 Walker B; other site 443906005067 D-loop; other site 443906005068 H-loop/switch region; other site 443906005069 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 443906005070 Predicted metal-sulfur cluster biosynthetic enzyme [General function prediction only]; Region: PaaD; COG2151 443906005071 Cysteine desulfurase activator ATPase [Posttranslational modification, protein turnover, chaperones]; Region: sufC; COG0396 443906005072 ABC-type transport system involved in Fe-S cluster assembly, ATPase component; Region: ABC_FeS_Assembly; cd03217 443906005073 Walker A/P-loop; other site 443906005074 ATP binding site [chemical binding]; other site 443906005075 Q-loop/lid; other site 443906005076 ABC transporter signature motif; other site 443906005077 Walker B; other site 443906005078 D-loop; other site 443906005079 H-loop/switch region; other site 443906005080 Rieske non-heme iron oxygenase (RO) family, Rieske ferredoxin component; composed of the Rieske ferredoxin component of some three-component RO systems including biphenyl dioxygenase (BPDO) and carbazole 1,9a-dioxygenase (CARDO). The RO family comprise a...; Region: Rieske_RO_ferredoxin; cd03528 443906005081 [2Fe-2S] cluster binding site [ion binding]; other site 443906005082 FeS assembly protein SufD; Region: sufD; TIGR01981 443906005083 Uncharacterized protein family (UPF0051); Region: UPF0051; pfam01458 443906005084 cysteine desulfurase activator complex subunit SufB; Provisional; Region: PRK11814; cl03223 443906005085 FeS assembly protein SufB; Region: sufB; TIGR01980 443906005086 Cytochrome oxidase assembly protein; Region: COX15-CtaA; pfam02628 443906005087 Uncharacterized protein required for cytochrome oxidase assembly [Posttranslational modification, protein turnover, chaperones]; Region: CtaA; COG1612 443906005088 protoheme IX farnesyltransferase; Provisional; Region: PRK04375 443906005089 UbiA prenyltransferase family; Region: UbiA; pfam01040 443906005090 Transketolase [Carbohydrate transport and metabolism]; Region: TktA; COG0021 443906005091 Thiamine pyrophosphate (TPP) family, Transketolase (TK) subfamily, TPP-binding module; TK catalyzes the transfer of a two-carbon unit from ketose phosphates to aldose phosphates. In heterotrophic organisms, TK provides a link between glycolysis and the...; Region: TPP_TK; cd02012 443906005092 TPP-binding site [chemical binding]; other site 443906005093 dimer interface [polypeptide binding]; other site 443906005094 Pyrimidine (PYR) binding domain of 1-deoxy-D-xylulose-5-phosphate synthase (DXS), transketolase (TK), and related proteins; Region: TPP_PYR_DXS_TK_like; cd07033 443906005095 PYR/PP interface [polypeptide binding]; other site 443906005096 dimer interface [polypeptide binding]; other site 443906005097 TPP binding site [chemical binding]; other site 443906005098 Transketolase, C-terminal domain; Region: Transketolase_C; pfam02780 443906005099 Transaldolase-like proteins from plants and bacteria; Region: Transaldolase_like; cd00955 443906005100 putative active site [active] 443906005101 transaldolase; Provisional; Region: PRK03903 443906005102 catalytic residue [active] 443906005103 bifunctional transaldolase/phosoglucose isomerase; Validated; Region: PRK09533 443906005104 Phosphoglucose isomerase (PGI) contains two SIS (Sugar ISomerase) domains. This classification is based on the alignment of the first SIS domain. PGI is a multifunctional enzyme which as an intracellular dimer catalyzes the reversible isomerization of...; Region: SIS_PGI_1; cd05015 443906005105 active site 443906005106 dimer interface [polypeptide binding]; other site 443906005107 SIS domain. SIS (Sugar ISomerase) domains are found in many phosphosugar isomerases and phosphosugar binding proteins. SIS domains are also found in proteins that regulate the expression of genes involved in synthesis of phosphosugars; Region: SIS; cl00389 443906005108 glucose-6-phosphate 1-dehydrogenase; Validated; Region: PRK05722 443906005109 Glucose-6-phosphate dehydrogenase, NAD binding domain; Region: G6PD_N; pfam00479 443906005110 Glucose-6-phosphate dehydrogenase, C-terminal domain; Region: G6PD_C; pfam02781 443906005111 glucose-6-phosphate dehydrogenase assembly protein OpcA; Region: OpcA; TIGR00534 443906005112 Glucose-6-phosphate dehydrogenase subunit; Region: OpcA_G6PD_assem; pfam10128 443906005113 6-phosphogluconolactonase/Glucosamine-6-phosphate isomerase/deaminase [Carbohydrate transport and metabolism]; Region: NagB; COG0363 443906005114 6PGL: 6-Phosphogluconolactonase (6PGL) subfamily; 6PGL catalyzes the second step of the oxidative phase of the pentose phosphate pathway, the hydrolyzation of 6-phosphoglucono-1,5-lactone (delta form) to 6-phosphogluconate. 6PGL is thought to guard...; Region: 6PGL; cd01400 443906005115 putative active site [active] 443906005116 Domain of unknown function (DUF4109); Region: DUF4109; pfam13397 443906005117 preprotein translocase subunit SecG; Reviewed; Region: secG; PRK06870 443906005118 Triosephosphate isomerase (TIM) is a glycolytic enzyme that catalyzes the interconversion of dihydroxyacetone phosphate and D-glyceraldehyde-3-phosphate. The reaction is very efficient and requires neither cofactors nor metal ions. TIM, usually...; Region: TIM; cd00311 443906005119 triosephosphate isomerase; Provisional; Region: PRK14565 443906005120 substrate binding site [chemical binding]; other site 443906005121 dimer interface [polypeptide binding]; other site 443906005122 catalytic triad [active] 443906005123 Phosphoglycerate kinase; Region: PGK; pfam00162 443906005124 Phosphoglycerate kinase (PGK) is a monomeric enzyme which catalyzes the transfer of the high-energy phosphate group of 1,3-bisphosphoglycerate to ADP, forming ATP and 3-phosphoglycerate. This reaction represents the first of the two substrate-level...; Region: Phosphoglycerate_kinase; cd00318 443906005125 substrate binding site [chemical binding]; other site 443906005126 hinge regions; other site 443906005127 ADP binding site [chemical binding]; other site 443906005128 catalytic site [active] 443906005129 Glyceraldehyde-3-phosphate dehydrogenase/erythrose-4-phosphate dehydrogenase [Carbohydrate transport and metabolism]; Region: GapA; COG0057 443906005130 Glyceraldehyde 3-phosphate dehydrogenase, NAD binding domain; Region: Gp_dh_N; pfam00044 443906005131 Glyceraldehyde 3-phosphate dehydrogenase, C-terminal domain; Region: Gp_dh_C; pfam02800 443906005132 Superoxide dismutase [Inorganic ion transport and metabolism]; Region: SodA; COG0605 443906005133 Iron/manganese superoxide dismutases, alpha-hairpin domain; Region: Sod_Fe_N; pfam00081 443906005134 Iron/manganese superoxide dismutases, C-terminal domain; Region: Sod_Fe_C; pfam02777 443906005135 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG1481 443906005136 Sporulation Regulator WhiA N terminal; Region: WhiA_N; pfam10298 443906005137 glmZ(sRNA)-inactivating NTPase; Provisional; Region: PRK05416 443906005138 shikimate kinase; Reviewed; Region: aroK; PRK00131 443906005139 excinuclease ABC subunit C; Validated; Region: uvrC; PRK00558 443906005140 Catalytic GIY-YIG domain of nucleotide excision repair endonucleases UvrC, Cho, and similar proteins; Region: GIY-YIG_UvrC_Cho; cd10434 443906005141 GIY-YIG motif/motif A; other site 443906005142 active site 443906005143 catalytic site [active] 443906005144 putative DNA binding site [nucleotide binding]; other site 443906005145 metal binding site [ion binding]; metal-binding site 443906005146 UvrC Helix-hairpin-helix N-terminal; Region: UvrC_HhH_N; pfam08459 443906005147 excinuclease ABC subunit A; Reviewed; Region: uvrA; PRK00349 443906005148 ATP-binding cassette domain I of the excision repair protein UvrA; Region: ABC_UvrA_I; cd03270 443906005149 ATP-binding cassette domain I of the excision repair protein UvrA; Region: ABC_UvrA_I; cd03270 443906005150 ATP-binding cassette domain II of the excision repair protein UvrA; Region: ABC_UvrA_II; cd03271 443906005151 excinuclease ABC subunit B; Provisional; Region: PRK05298 443906005152 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 443906005153 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 443906005154 nucleotide binding region [chemical binding]; other site 443906005155 ATP-binding site [chemical binding]; other site 443906005156 Ultra-violet resistance protein B; Region: UvrB; pfam12344 443906005157 UvrB/uvrC motif; Region: UVR; pfam02151 443906005158 Dephospho-CoA kinase [Coenzyme metabolism]; Region: CoaE; COG0237 443906005159 Dephospho-coenzyme A kinase (DPCK, EC 2.7.1.24) catalyzes the phosphorylation of dephosphocoenzyme A (dCoA) to yield CoA, which is the final step in CoA biosynthesis; Region: DPCK; cd02022 443906005160 CoA-binding site [chemical binding]; other site 443906005161 ATP-binding [chemical binding]; other site 443906005162 30S ribosomal protein S1; Reviewed; Region: rpsA; PRK07899 443906005163 S1_RPS1_repeat_ec1_hs1: Ribosomal protein S1 (RPS1) domain. RPS1 is a component of the small ribosomal subunit thought to be involved in the recognition and binding of mRNA's during translation initiation. The bacterial RPS1 domain architecture...; Region: S1_RPS1_repeat_ec1_hs1; cd05687 443906005164 RNA binding site [nucleotide binding]; other site 443906005165 S1_RPS1_repeat_ec2_hs2: Ribosomal protein S1 (RPS1) domain. RPS1 is a component of the small ribosomal subunit thought to be involved in the recognition and binding of mRNA's during translation initiation. The bacterial RPS1 domain architecture...; Region: S1_RPS1_repeat_ec2_hs2; cd04465 443906005166 RNA binding site [nucleotide binding]; other site 443906005167 S1_like: Ribosomal protein S1-like RNA-binding domain. Found in a wide variety of RNA-associated proteins. Originally identified in S1 ribosomal protein. This superfamily also contains the Cold Shock Domain (CSD), which is a homolog of the S1 domain; Region: S1_like; cl09927 443906005168 RNA binding site [nucleotide binding]; other site 443906005169 S1_PNPase: Polynucleotide phosphorylase (PNPase), ), S1-like RNA-binding domain. PNPase is a polyribonucleotide nucleotidyl transferase that degrades mRNA. It is a trimeric multidomain protein. The C-terminus contains the S1 domain which binds ssRNA; Region: S1_PNPase; cd04472 443906005170 RNA binding site [nucleotide binding]; other site 443906005171 domain interface; other site 443906005172 Bacterial protein of unknown function (DUF885); Region: DUF885; pfam05960 443906005173 PTS_IIA, PTS system, fructose/mannitol specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_fru; cd00211 443906005174 active site 443906005175 phosphorylation site [posttranslational modification] 443906005176 DNA polymerase I; Provisional; Region: PRK05755 443906005177 PIN domain of the 5'-3' exonuclease of Taq DNA polymerase I and homologs; Region: PIN_53EXO; cd09859 443906005178 active site 443906005179 metal binding site 1 [ion binding]; metal-binding site 443906005180 putative 5' ssDNA interaction site; other site 443906005181 metal binding site 3; metal-binding site 443906005182 metal binding site 2 [ion binding]; metal-binding site 443906005183 H3TH domain of the 5'-3' exonuclease of Taq DNA polymerase I and homologs; Region: H3TH_53EXO; cd09898 443906005184 putative DNA binding site [nucleotide binding]; other site 443906005185 putative metal binding site [ion binding]; other site 443906005186 inactive DEDDy 3'-5' exonuclease domain of Bacillus stearothermophilus DNA polymerase I and similar family-A DNA polymerases; Region: DNA_polA_I_Bacillus_like_exo; cd06140 443906005187 Polymerase I functions primarily to fill DNA gaps that arise during DNA repair, recombination and replication; Region: DNA_pol_A_pol_I_C; cd08637 443906005188 active site 443906005189 DNA binding site [nucleotide binding] 443906005190 catalytic site [active] 443906005191 PaaI_thioesterase is a tetrameric acyl-CoA thioesterase with a hot dog fold and one of several proteins responsible for phenylacetic acid (PA) degradation in bacteria. Although orthologs of PaaI exist in archaea and eukaryotes, their function has not...; Region: PaaI_thioesterase; cd03443 443906005192 CoenzymeA binding site [chemical binding]; other site 443906005193 subunit interaction site [polypeptide binding]; other site 443906005194 PHB binding site; other site 443906005195 Response regulator with putative antiterminator output domain [Signal transduction mechanisms]; Region: AmiR; COG3707 443906005196 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 443906005197 active site 443906005198 phosphorylation site [posttranslational modification] 443906005199 intermolecular recognition site; other site 443906005200 dimerization interface [polypeptide binding]; other site 443906005201 ANTAR domain; Region: ANTAR; pfam03861 443906005202 pyruvate kinase; Provisional; Region: PRK06247 443906005203 Pyruvate kinase (PK): Large allosteric enzyme that regulates glycolysis through binding of the substrate, phosphoenolpyruvate, and one or more allosteric effectors. Like other allosteric enzymes, PK has a high substrate affinity R state and a low...; Region: Pyruvate_Kinase; cl17342 443906005204 domain interfaces; other site 443906005205 active site 443906005206 glutamate synthase subunit beta; Reviewed; Region: gltD; PRK12810 443906005207 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450 443906005208 glutamate synthase subunit alpha; Provisional; Region: gltB; PRK11750 443906005209 Glutamine amidotransferases class-II (Gn-AT), glutamate synthase (GltS)-type. GltS is a homodimer that synthesizes L-glutamate from 2-oxoglutarate and L-glutamine, an important step in ammonia assimilation in bacteria, cyanobacteria and plants. The...; Region: GltS; cd00713 443906005210 active site 443906005211 dimer interface [polypeptide binding]; other site 443906005212 Glutamate synthase central domain; Region: Glu_syn_central; pfam04898 443906005213 Glutamate synthase (GltS) FMN-binding domain. GltS is a complex iron-sulfur flavoprotein that catalyzes the reductive synthesis of L-glutamate from 2-oxoglutarate and L-glutamine via intramolecular channelling of ammonia, a reaction in the plant, yeast...; Region: GltS_FMN; cd02808 443906005214 active site 443906005215 FMN binding site [chemical binding]; other site 443906005216 substrate binding site [chemical binding]; other site 443906005217 3Fe-4S cluster binding site [ion binding]; other site 443906005218 gltb_C. This domain is found at the C-terminus of the large subunit (gltB) of glutamate synthase (GltS). GltS encodes a complex iron-sulfur flavoprotein that catalyzes the synthesis of L-glutamate from L-glutamine and 2-oxoglutarate. It requires the...; Region: gltB_C; cd00982 443906005219 domain interface; other site 443906005220 prolipoprotein diacylglyceryl transferase; Reviewed; Region: PRK00052 443906005221 Ttryptophan synthase (TRPS) alpha subunit (TSA). TPRS is a bifunctional tetrameric enzyme (2 alpha and 2 beta subunits) that catalyzes the last two steps of L-tryptophan biosynthesis. Alpha and beta subunit catalyze two distinct reactions which are both...; Region: Tryptophan_synthase_alpha; cd04724 443906005222 substrate binding site [chemical binding]; other site 443906005223 active site 443906005224 catalytic residues [active] 443906005225 heterodimer interface [polypeptide binding]; other site 443906005226 tryptophan synthase, beta subunit; Region: trpB; TIGR00263 443906005227 Tryptophan synthase-beta: Trptophan synthase is a bifunctional enzyme that catalyses the last two steps in the biosynthesis of L-tryptophan via its alpha and beta reactions. In the alpha reaction, indole 3-glycerol phosphate is cleaved reversibly to...; Region: Trp-synth_B; cd06446 443906005228 pyridoxal 5'-phosphate binding site [chemical binding]; other site 443906005229 catalytic residue [active] 443906005230 Indole-3-glycerol phosphate synthase (IGPS); an enzyme in the tryptophan biosynthetic pathway, catalyzing the ring closure reaction of 1-(o-carboxyphenylamino)-1-deoxyribulose-5-phosphate (CdRP) to indole-3-glycerol phosphate (IGP), accompanied by the...; Region: IGPS; cd00331 443906005231 active site 443906005232 ribulose/triose binding site [chemical binding]; other site 443906005233 phosphate binding site [ion binding]; other site 443906005234 substrate (anthranilate) binding pocket [chemical binding]; other site 443906005235 product (indole) binding pocket [chemical binding]; other site 443906005236 Tryptophan-associated transmembrane protein (Trp_oprn_chp); Region: Trp_oprn_chp; cl17850 443906005237 anthranilate synthase component I; Provisional; Region: PRK13571 443906005238 Anthranilate synthase component I, N terminal region; Region: Anth_synt_I_N; pfam04715 443906005239 chorismate binding enzyme; Region: Chorismate_bind; pfam00425 443906005240 phosphoribosyl-AMP cyclohydrolase; Reviewed; Region: hisI; PRK00051 443906005241 The cyclase subunit of imidazoleglycerol phosphate synthase (HisF). Imidazole glycerol phosphate synthase (IGPS) catalyzes the fifth step of histidine biosynthesis, the formation of the imidazole ring. IGPS converts N1-(5'-phosphoribulosyl)...; Region: HisF; cd04731 443906005242 Histidine biosynthesis protein; Region: His_biosynth; pfam00977 443906005243 substrate binding site [chemical binding]; other site 443906005244 glutamase interaction surface [polypeptide binding]; other site 443906005245 ATP phosphoribosyltransferase; Reviewed; Region: hisG; PRK00489 443906005246 ATP phosphoribosyltransferase; Region: hisG; TIGR00070 443906005247 ATP phosphoribosyltransferase, C-terminal domain; Region: HisG_C-term; TIGR03455 443906005248 Nucleoside Triphosphate Pyrophosphohydrolase (EC 3.6.1.8) MazG-like domain found in Mycobacterium tuberculosis phosphoribosyl-ATP pyrophosphohydrolase (HisE or PRATP-PH) and its bacterial homologs; Region: NTP-PPase_HisE; cd11547 443906005249 homodimer interface [polypeptide binding]; other site 443906005250 putative metal binding site [ion binding]; other site 443906005251 FKBP-type peptidyl-prolyl cis-trans isomerase; Region: FKBP_C; pfam00254 443906005252 Pentose-5-phosphate-3-epimerase [Carbohydrate transport and metabolism]; Region: Rpe; COG0036 443906005253 Ribulose-5-phosphate 3-epimerase (RPE). This enzyme catalyses the interconversion of D-ribulose 5-phosphate (Ru5P) into D-xylulose 5-phosphate, as part of the Calvin cycle (reductive pentose phosphate pathway) in chloroplasts and in the oxidative pentose...; Region: RPE; cd00429 443906005254 substrate binding site [chemical binding]; other site 443906005255 hexamer interface [polypeptide binding]; other site 443906005256 metal binding site [ion binding]; metal-binding site 443906005257 RNA binding domain of NusB (N protein-Utilization Substance B) and Sun (also known as RrmB or Fmu) proteins. This family includes two orthologous groups exemplified by the transcription termination factor NusB and the N-terminal domain of the...; Region: NusB_Sun; cl00223 443906005258 putative RNA binding site [nucleotide binding]; other site 443906005259 16S rRNA methyltransferase B; Provisional; Region: PRK14902 443906005260 NOL1/NOP2/sun family putative RNA methylase; Region: nop2p; TIGR00446 443906005261 methionyl-tRNA formyltransferase; Reviewed; Region: fmt; PRK00005 443906005262 Methionyl-tRNA formyltransferase, N-terminal hydrolase domain; Region: FMT_core_Met-tRNA-FMT_N; cd08646 443906005263 putative active site [active] 443906005264 substrate binding site [chemical binding]; other site 443906005265 putative cosubstrate binding site; other site 443906005266 catalytic site [active] 443906005267 C-terminal domain of Formyltransferase and other enzymes; Region: Met_tRNA_FMT_C; cd08704 443906005268 substrate binding site [chemical binding]; other site 443906005269 primosome assembly protein PriA; Provisional; Region: PRK14873 443906005270 S-adenosylmethionine synthetase; Validated; Region: PRK05250 443906005271 S-adenosylmethionine synthetase, N-terminal domain; Region: S-AdoMet_synt_N; pfam00438 443906005272 S-adenosylmethionine synthetase, central domain; Region: S-AdoMet_synt_M; pfam02772 443906005273 S-adenosylmethionine synthetase, C-terminal domain; Region: S-AdoMet_synt_C; pfam02773 443906005274 Flavoprotein; Region: Flavoprotein; pfam02441 443906005275 bifunctional phosphopantothenoylcysteine decarboxylase/phosphopantothenate synthase; Validated; Region: PRK05579 443906005276 DNA / pantothenate metabolism flavoprotein; Region: DFP; pfam04127 443906005277 DNA-directed RNA polymerase subunit omega; Reviewed; Region: rpoZ; PRK00392 443906005278 Guanylate kinase [Nucleotide transport and metabolism]; Region: Gmk; COG0194 443906005279 Guanosine monophosphate kinase (GMPK, EC 2.7.4.8), also known as guanylate kinase (GKase), catalyzes the reversible phosphoryl transfer from adenosine triphosphate (ATP) to guanosine monophosphate (GMP) to yield adenosine diphosphate (ADP) and guanosine...; Region: GMPK; cd00071 443906005280 catalytic site [active] 443906005281 G-X2-G-X-G-K; other site 443906005282 Orotidine 5'-phosphate decarboxylase (ODCase) is a dimeric enzyme that decarboxylates orotidine 5'-monophosphate (OMP) to form uridine 5'-phosphate (UMP), an essential step in the pyrimidine biosynthetic pathway. In mammals, UMP synthase...; Region: OMP_decarboxylase_like; cd04725 443906005283 active site 443906005284 dimer interface [polypeptide binding]; other site 443906005285 carbamoyl phosphate synthase large subunit; Reviewed; Region: carB; PRK05294 443906005286 Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289 443906005287 ATP-grasp domain; Region: ATP-grasp_4; cl17255 443906005288 Carbamoyl-phosphate synthetase large chain, oligomerisation domain; Region: CPSase_L_D3; pfam02787 443906005289 Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289 443906005290 ATP-grasp domain; Region: ATP-grasp_4; cl17255 443906005291 Methylglyoxal synthase-like domain from type II glutamine-dependent carbamoyl phosphate synthetase (CSP). CSP, a CarA and CarB heterodimer, catalyzes the production of carbamoyl phosphate which is subsequently employed in the metabolic pathways...; Region: MGS_CPS_II; cd01424 443906005292 IMP binding site; other site 443906005293 dimer interface [polypeptide binding]; other site 443906005294 interdomain contacts; other site 443906005295 partial ornithine binding site; other site 443906005296 carbamoyl phosphate synthase small subunit; Reviewed; Region: PRK12564 443906005297 Carbamoyl-phosphate synthase small chain, CPSase domain; Region: CPSase_sm_chain; smart01097 443906005298 Small chain of the glutamine-dependent form of carbamoyl phosphate synthase, CPSase II; Region: GATase1_CPSase; cd01744 443906005299 catalytic site [active] 443906005300 subunit interface [polypeptide binding]; other site 443906005301 dihydroorotase; Validated; Region: pyrC; PRK09357 443906005302 Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281 443906005303 Dihydroorotase (DHOase), subgroup IIa; DHOases catalyze the reversible interconversion of carbamoyl aspartate to dihydroorotate, a key reaction in pyrimidine biosynthesis. This subgroup also contains proteins that lack the active site, like unc-33, a C; Region: DHOase_IIa; cd01317 443906005304 active site 443906005305 aspartate carbamoyltransferase catalytic subunit; Provisional; Region: pyrB; PRK00856 443906005306 Aspartate/ornithine carbamoyltransferase, carbamoyl-P binding domain; Region: OTCace_N; pfam02729 443906005307 Aspartate/ornithine carbamoyltransferase, Asp/Orn binding domain; Region: OTCace; pfam00185 443906005308 Pyrimidine operon attenuation protein/uracil phosphoribosyltransferase [Nucleotide transport and metabolism]; Region: PyrR; COG2065 443906005309 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 443906005310 active site 443906005311 acetyl-CoA synthetase; Provisional; Region: PRK00174 443906005312 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 443906005313 acyl-activating enzyme (AAE) consensus motif; other site 443906005314 AMP binding site [chemical binding]; other site 443906005315 active site 443906005316 CoA binding site [chemical binding]; other site 443906005317 ABC-type nitrate/sulfonate/bicarbonate transport system, permease component [Inorganic ion transport and metabolism]; Region: TauC; COG0600 443906005318 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 443906005319 dimer interface [polypeptide binding]; other site 443906005320 conserved gate region; other site 443906005321 putative PBP binding loops; other site 443906005322 ABC-ATPase subunit interface; other site 443906005323 ABC transporter, substrate-binding protein, aliphatic sulfonates family; Region: SsuA_fam; TIGR01728 443906005324 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 443906005325 substrate binding pocket [chemical binding]; other site 443906005326 membrane-bound complex binding site; other site 443906005327 hinge residues; other site 443906005328 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 443906005329 Walker A/P-loop; other site 443906005330 ATP binding site [chemical binding]; other site 443906005331 ABC transporter; Region: ABC_tran; pfam00005 443906005332 Q-loop/lid; other site 443906005333 ABC transporter signature motif; other site 443906005334 Walker B; other site 443906005335 D-loop; other site 443906005336 H-loop/switch region; other site 443906005337 transcription antitermination factor NusB; Region: nusB; TIGR01951 443906005338 putative RNA binding site [nucleotide binding]; other site 443906005339 elongation factor P; Validated; Region: PRK00529 443906005340 Elongation factor P (EF-P) KOW-like domain; Region: EFP_N; pfam08207 443906005341 S1_EF-P_repeat_1: Translation elongation factor P (EF-P), S1-like RNA-binding domain, repeat 1. EF-P stimulates the peptidyltransferase activity in the prokaryotic 70S ribosome. EF-P enhances the synthesis of certain dipeptides with...; Region: S1_EF-P_repeat_1; cd04470 443906005342 RNA binding site [nucleotide binding]; other site 443906005343 S1_EF-P_repeat_2: Translation elongation factor P (EF-P), S1-like RNA-binding domain, repeat 1. EF-P stimulates the peptidyltransferase activity in the prokaryotic 70S ribosome. EF-P enhances the synthesis of certain dipeptides with...; Region: S1_EF-P_repeat_2; cd05794 443906005344 RNA binding site [nucleotide binding]; other site 443906005345 Dehydroquinase class II; Region: DHquinase_II; pfam01220 443906005346 Dehydroquinase (DHQase), type II. Dehydroquinase (or 3-dehydroquinate dehydratase) catalyzes the reversible dehydration of 3-dehydroquinate to form 3-dehydroshikimate. This reaction is part of two metabolic pathways: the biosynthetic shikimate pathway...; Region: DHQase_II; cd00466 443906005347 trimer interface [polypeptide binding]; other site 443906005348 active site 443906005349 dimer interface [polypeptide binding]; other site 443906005350 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 443906005351 3-ketoacyl-(acyl-carrier-protein) reductase; Provisional; Region: PRK12859 443906005352 NAD(P) binding site [chemical binding]; other site 443906005353 active site 443906005354 Dehydroquinate synthase (DHQS) catalyzes the conversion of DAHP to DHQ in shikimate pathway for aromatic compounds synthesis; Region: DHQS; cd08195 443906005355 active site 443906005356 dimer interface [polypeptide binding]; other site 443906005357 metal binding site [ion binding]; metal-binding site 443906005358 Shikimate kinase (SK) is the fifth enzyme in the shikimate pathway, a seven-step biosynthetic pathway which converts erythrose-4-phosphate to chorismic acid, found in bacteria, fungi and plants. Chorismic acid is a important intermediate in the synthesis...; Region: SK; cd00464 443906005359 Shikimate kinase; Region: SKI; pfam01202 443906005360 ADP binding site [chemical binding]; other site 443906005361 magnesium binding site [ion binding]; other site 443906005362 putative shikimate binding site; other site 443906005363 Chorismate synthase [Amino acid transport and metabolism]; Region: AroC; COG0082 443906005364 Chorismase synthase, the enzyme catalyzing the final step of the shikimate pathway; Region: Chorismate_synthase; cd07304 443906005365 Tetramer interface [polypeptide binding]; other site 443906005366 active site 443906005367 FMN-binding site [chemical binding]; other site 443906005368 shikimate 5-dehydrogenase; Reviewed; Region: aroE; PRK00258 443906005369 Shikimate dehydrogenase substrate binding domain; Region: Shikimate_dh_N; pfam08501 443906005370 NAD(P) binding domain of Shikimate dehydrogenase; Region: NAD_bind_Shikimate_DH; cd01065 443906005371 shikimate binding site; other site 443906005372 NAD(P) binding site [chemical binding]; other site 443906005373 YceG-like family; Region: YceG; pfam02618 443906005374 proteins similar to Escherichia coli yceG; Region: yceG_like; cd08010 443906005375 dimerization interface [polypeptide binding]; other site 443906005376 Uncharacterized protein family (UPF0081); Region: UPF0081; pfam03652 443906005377 alanyl-tRNA synthetase; Reviewed; Region: alaS; PRK00252 443906005378 Alanyl-tRNA synthetase (AlaRS) class II core catalytic domain. AlaRS is a homodimer. It is responsible for the attachment of alanine to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for ATP-dependent...; Region: AlaRS_core; cd00673 443906005379 motif 1; other site 443906005380 active site 443906005381 motif 2; other site 443906005382 motif 3; other site 443906005383 Threonyl and Alanyl tRNA synthetase second additional domain; Region: tRNA_SAD; pfam07973 443906005384 30S ribosomal protein S4; Validated; Region: rpsD; PRK05327 443906005385 Ribosomal protein S4/S9 N-terminal domain; Region: Ribosomal_S4; pfam00163 443906005386 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 443906005387 RNA binding surface [nucleotide binding]; other site 443906005388 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 443906005389 Walker A motif; other site 443906005390 ATP binding site [chemical binding]; other site 443906005391 Walker B motif; other site 443906005392 recombination factor protein RarA; Reviewed; Region: PRK13342 443906005393 MgsA AAA+ ATPase C terminal; Region: MgsA_C; pfam12002 443906005394 Domain of Unknown Function (DUF349); Region: DUF349; pfam03993 443906005395 Domain of Unknown Function (DUF349); Region: DUF349; pfam03993 443906005396 Domain of unknown function (DUF4095); Region: DUF4095; pfam13338 443906005397 Guanosine polyphosphate pyrophosphohydrolases/synthetases [Signal transduction mechanisms / Transcription]; Region: SpoT; COG0317 443906005398 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 443906005399 Zn2+ binding site [ion binding]; other site 443906005400 Mg2+ binding site [ion binding]; other site 443906005401 Nucleotidyltransferase (NT) domain of RelA- and SpoT-like ppGpp synthetases and hydrolases; Region: NT_Rel-Spo_like; cd05399 443906005402 synthetase active site [active] 443906005403 NTP binding site [chemical binding]; other site 443906005404 metal binding site [ion binding]; metal-binding site 443906005405 TGS_RelA_SpoT: The RelA (SpoT) protein, also referred to as ppGpp hydrolase/synthetase, is a ribosome-associated protein that is activated during amino acid starvation and thought to mediate the stringent response. RelA contains a TGS domain, named after...; Region: TGS_RelA_SpoT; cd01668 443906005406 ACT domain found C-terminal of the RelA/SpoT domains; Region: ACT_RelA-SpoT; cd04876 443906005407 Rhodanese Homology Domain (RHOD); an alpha beta fold domain found duplicated in the rhodanese protein. The cysteine containing enzymatically active version of the domain is also found in the Cdc25 class of protein phosphatases and a variety of proteins...; Region: RHOD; cd00158 443906005408 active site residue [active] 443906005409 preprotein translocase subunit SecF; Reviewed; Region: secF; PRK13022 443906005410 Protein export membrane protein; Region: SecD_SecF; pfam02355 443906005411 Preprotein translocase subunit SecD [Intracellular trafficking and secretion]; Region: SecD; COG0342 443906005412 Protein export membrane protein; Region: SecD_SecF; cl14618 443906005413 Preprotein translocase subunit; Region: YajC; pfam02699 443906005414 Holliday junction DNA helicase RuvB; Reviewed; Region: ruvB; PRK00080 443906005415 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 443906005416 Walker A motif; other site 443906005417 ATP binding site [chemical binding]; other site 443906005418 Walker B motif; other site 443906005419 arginine finger; other site 443906005420 Holliday junction DNA helicase ruvB C-terminus; Region: RuvB_C; pfam05491 443906005421 Holliday junction DNA helicase RuvA; Reviewed; Region: ruvA; PRK00116 443906005422 RuvA N terminal domain; Region: RuvA_N; pfam01330 443906005423 Holliday junction resolvases (HJRs) are endonucleases that specifically resolve Holliday junction DNA intermediates during homologous recombination. HJR's occur in archaea, bacteria, and in the mitochondria of certain fungi, however this CD...; Region: RuvC_resolvase; cd00529 443906005424 active site 443906005425 putative DNA-binding cleft [nucleotide binding]; other site 443906005426 dimer interface [polypeptide binding]; other site 443906005427 hypothetical protein; Validated; Region: PRK00110 443906005428 Glutamine Amidotransferase (GATase_I) involved in pyridoxine biosynthesis; Region: GATase1_PB; cd01749 443906005429 imidazole glycerol phosphate synthase subunit HisH; Provisional; Region: hisH; PRK13143 443906005430 predicted active site [active] 443906005431 catalytic triad [active] 443906005432 pyridoxal 5'-phosphate synthase, synthase subunit Pdx1; Region: TIGR00343 443906005433 PdxS is a subunit of the pyridoxal 5'-phosphate (PLP) synthase, an important enzyme in deoxyxylulose 5-phosphate (DXP)-independent pathway for de novo biosynthesis of PLP, present in some eubacteria, in archaea, fungi, plants, plasmodia, and some...; Region: pdxS; cd04727 443906005434 active site 443906005435 multimer interface [polypeptide binding]; other site 443906005436 FHIT (fragile histidine family): FHIT proteins, related to the HIT family carry a motif HxHxH/Qxx (x, is a hydrophobic amino acid), On the basis of sequence, substrate specificity, structure, evolution and mechanism, HIT proteins are classified into...; Region: FHIT; cd01275 443906005437 nucleotide binding site/active site [active] 443906005438 HIT family signature motif; other site 443906005439 catalytic residue [active] 443906005440 threonyl-tRNA synthetase; Reviewed; Region: thrS; PRK12305 443906005441 Threonyl and Alanyl tRNA synthetase second additional domain; Region: tRNA_SAD; smart00863 443906005442 Threonyl-tRNA synthetase (ThrRS) class II core catalytic domain. ThrRS is a homodimer. It is responsible for the attachment of threonine to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for ATP-dependent...; Region: ThrRS_core; cd00771 443906005443 active site 443906005444 dimer interface [polypeptide binding]; other site 443906005445 motif 1; other site 443906005446 motif 2; other site 443906005447 motif 3; other site 443906005448 ThrRS Threonyl-anticodon binding domain. ThrRS belongs to class II aminoacyl-tRNA synthetases (aaRS). This alignment contains the anticodon binding domain, which is responsible for specificity in tRNA-binding, so that the activated amino acid is...; Region: ThrRS_anticodon; cd00860 443906005449 anticodon binding site; other site 443906005450 Transcriptional regulator, contains sigma factor-related N-terminal domain [Transcription]; Region: DeoR; COG2390 443906005451 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 443906005452 DNA binding residues [nucleotide binding] 443906005453 Putative sugar-binding domain; Region: Sugar-bind; pfam04198 443906005454 Glycerol-3-phosphate dehydrogenase [Energy production and conversion]; Region: GlpA; COG0578 443906005455 Glutathione (GSH) peroxidase family; tetrameric selenoenzymes that catalyze the reduction of a variety of hydroperoxides including lipid peroxidases, using GSH as a specific electron donor substrate. GSH peroxidase contains one selenocysteine residue per...; Region: GSH_Peroxidase; cd00340 443906005456 catalytic residues [active] 443906005457 dimer interface [polypeptide binding]; other site 443906005458 DinB superfamily; Region: DinB_2; pfam12867 443906005459 Protein of unknown function (DUF664); Region: DUF664; pfam04978 443906005460 hypothetical protein; Provisional; Region: PRK04233 443906005461 PTS_IIA, PTS system, mannose/sorbose specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIA_man; cl00025 443906005462 Histidine-containing phosphocarrier protein (HPr)-like proteins. HPr is a central component of the bacterial phosphoenolpyruvate sugar phosphotransferase system (PTS). The PTS catalyses the phosphorylation of sugar substrates during their translocation...; Region: PTS-HPr_like; cd00367 443906005463 dimerization domain swap beta strand [polypeptide binding]; other site 443906005464 regulatory protein interface [polypeptide binding]; other site 443906005465 active site 443906005466 regulatory phosphorylation site [posttranslational modification]; other site 443906005467 DAK2 domain; Region: Dak2; cl03685 443906005468 dihydroxyacetone kinase subunit DhaK; Provisional; Region: PRK14481 443906005469 Dihydroxyacetone kinase [Carbohydrate transport and metabolism]; Region: DAK1; COG2376 443906005470 Glycerol uptake facilitator and related permeases (Major Intrinsic Protein Family) [Carbohydrate transport and metabolism]; Region: GlpF; COG0580 443906005471 amphipathic channel; other site 443906005472 Asn-Pro-Ala signature motifs; other site 443906005473 glycerol kinase; Provisional; Region: glpK; PRK00047 443906005474 Cellulomonas sp. glycerol kinase-like proteins; belongs to the FGGY family of carbohydrate kinases; Region: FGGY_CsGK_like; cd07789 443906005475 N- and C-terminal domain interface [polypeptide binding]; other site 443906005476 active site 443906005477 MgATP binding site [chemical binding]; other site 443906005478 catalytic site [active] 443906005479 metal binding site [ion binding]; metal-binding site 443906005480 putative homotetramer interface [polypeptide binding]; other site 443906005481 glycerol binding site [chemical binding]; other site 443906005482 homodimer interface [polypeptide binding]; other site 443906005483 Uncharacterized ACR, COG2135; Region: DUF159; pfam02586 443906005484 anthranilate phosphoribosyltransferase; Provisional; Region: trpD; PRK00188 443906005485 Glycosyl transferase family, helical bundle domain; Region: Glycos_trans_3N; pfam02885 443906005486 Glycosyl transferase family, a/b domain; Region: Glycos_transf_3; pfam00591 443906005487 Heme-copper oxidase subunit III. Heme-copper oxidases are transmembrane protein complexes in the respiratory chains of prokaryotes and mitochondria which couple the reduction of molecular oxygen to water to, proton pumping across the membrane. The...; Region: Heme_Cu_Oxidase_III_like; cd00386 443906005488 Subunit I/III interface [polypeptide binding]; other site 443906005489 Cytochrome c, mono- and diheme variants [Energy production and conversion]; Region: CccA; COG2010 443906005490 Cytochrome c; Region: Cytochrom_C; pfam00034 443906005491 Cytochrome c, mono- and diheme variants [Energy production and conversion]; Region: CccA; COG2010 443906005492 Cytochrome C oxidase, cbb3-type, subunit III; Region: Cytochrome_CBB3; pfam13442 443906005493 Rieske Fe-S protein [Energy production and conversion]; Region: QcrA; COG0723 443906005494 Rieske domain; a [2Fe-2S] cluster binding domain commonly found in Rieske non-heme iron oxygenase (RO) systems such as naphthalene and biphenyl dioxygenases, as well as in plant/cyanobacterial chloroplast b6f and mitochondrial cytochrome bc(1) complexes; Region: Rieske; cd03467 443906005495 iron-sulfur cluster [ion binding]; other site 443906005496 [2Fe-2S] cluster binding site [ion binding]; other site 443906005497 Cytochrome b subunit of the bc complex [Energy production and conversion]; Region: QcrB; COG1290 443906005498 heme bH binding site [chemical binding]; other site 443906005499 intrachain domain interface; other site 443906005500 heme bL binding site [chemical binding]; other site 443906005501 interchain domain interface [polypeptide binding]; other site 443906005502 Cytochrome b(N-terminal)/b6/petB; Region: Cytochrom_B_N_2; pfam13631 443906005503 Qo binding site; other site 443906005504 23S rRNA methyltransferase A; Provisional; Region: rrmA; PRK11088 443906005505 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 443906005506 S-adenosylmethionine binding site [chemical binding]; other site 443906005507 putative serine protease, regulator of sigma subunit; Hypothetical protein 443906005508 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 443906005509 Coenzyme A binding pocket [chemical binding]; other site 443906005510 Cytochrome c oxidase subunit IV; Region: Cyt_c_ox_IV; pfam12270 443906005511 Heme/copper-type cytochrome/quinol oxidases, subunit 1 [Energy production and conversion]; Region: CyoB; COG0843 443906005512 Ubiquinol oxidase subunit I. Ubiquinol oxidase, the terminal oxidase in the respiratory chains of aerobic bacteria, is a multi-chain transmembrane protein located in the cell membrane. It catalyzes the reduction of O2 and simultaneously pumps protons...; Region: Ubiquinol_Oxidase_I; cd01662 443906005513 D-pathway; other site 443906005514 Putative ubiquinol binding site [chemical binding]; other site 443906005515 Low-spin heme (heme b) binding site [chemical binding]; other site 443906005516 Putative water exit pathway; other site 443906005517 Binuclear center (heme o3/CuB) [ion binding]; other site 443906005518 K-pathway; other site 443906005519 Putative proton exit pathway; other site 443906005520 cytochrome c oxidase, subunit II; Region: CoxB; TIGR02866 443906005521 Cytochrome C oxidase subunit II, periplasmic domain; Region: COX2; pfam00116 443906005522 Fe-S cluster assembly scaffold protein [Posttranslational modification, protein turnover, chaperones]; Region: sufA; COG0316 443906005523 hypothetical protein; Provisional; Region: PRK07907 443906005524 M20 Dipeptidases; Region: M20_Dipept_like; cd03893 443906005525 active site 443906005526 metal binding site [ion binding]; metal-binding site 443906005527 dimer interface [polypeptide binding]; other site 443906005528 Protein of unknown function (DUF3043); Region: DUF3043; pfam11241 443906005529 dihydroorotate dehydrogenase 2; Reviewed; Region: PRK05286 443906005530 Dihydroorotate dehydrogenase (DHOD) class 2. DHOD catalyzes the oxidation of (S)-dihydroorotate to orotate. This is the fourth step and the only redox reaction in the de novo biosynthesis of UMP, the precursor of all pyrimidine nucleotides. DHOD requires...; Region: DHOD_2_like; cd04738 443906005531 quinone interaction residues [chemical binding]; other site 443906005532 active site 443906005533 catalytic residues [active] 443906005534 FMN binding site [chemical binding]; other site 443906005535 substrate binding site [chemical binding]; other site 443906005536 transcriptional regulator NrdR; Validated; Region: nrdR; PRK00464 443906005537 ATP cone domain; Region: ATP-cone; pfam03477 443906005538 Histidinol dehydrogenase, HisD, E.C 1.1.1.23. Histidinol dehydrogenase catalyzes the last two steps in the L-histidine biosynthesis pathway, which is conserved in bacteria, archaea, fungi, and plants. These last two steps are (i) the NAD-dependent...; Region: Histidinol_dh; cd06572 443906005539 histidinol dehydrogenase; Region: hisD; TIGR00069 443906005540 NAD binding site [chemical binding]; other site 443906005541 dimerization interface [polypeptide binding]; other site 443906005542 product binding site; other site 443906005543 substrate binding site [chemical binding]; other site 443906005544 zinc binding site [ion binding]; other site 443906005545 catalytic residues [active] 443906005546 Flavin reductase like domain; Region: Flavin_Reduct; smart00903 443906005547 DNA polymerase III subunit alpha; Validated; Region: dnaE; PRK05673 443906005548 Polymerase and Histidinol Phosphatase domain of alpha-subunit of bacterial polymerase III DnaE3; Region: PHP_PolIIIA_DnaE3; cd12113 443906005549 active site 443906005550 PHP Thumb interface [polypeptide binding]; other site 443906005551 metal binding site [ion binding]; metal-binding site 443906005552 DnaE_OBF: A subfamily of OB folds corresponding to the C-terminal OB-fold nucleic acid binding domain of Thermus aquaticus and Escherichia coli type C replicative DNA polymerase III alpha subunit (DnaE). The DNA polymerase holoenzyme of E. coli contains...; Region: DnaE_OBF; cd04485 443906005553 generic binding surface II; other site 443906005554 generic binding surface I; other site 443906005555 Pseudouridylate synthases, 23S RNA-specific [Translation, ribosomal structure and biogenesis]; Region: RluA; COG0564 443906005556 Pseudouridine synthase, RsuA/RluD family; Region: PseudoU_synth_RluCD_like; cd02869 443906005557 active site 443906005558 Protein of unknown function (DUF552); Region: DUF552; pfam04472 443906005559 Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzymes, YBL036c-like proteins; Region: PLPDE_III_YBL036c_like; cd00635 443906005560 pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site 443906005561 catalytic residue [active] 443906005562 cell division protein FtsZ; Validated; Region: PRK09330 443906005563 FtsZ is a GTPase that is similar to the eukaryotic tubulins and is essential for cell division in prokaryotes. FtsZ is capable of polymerizing in a GTP-driven process into structures similar to those formed by tubulin. FtsZ forms a ring-shaped septum at...; Region: FtsZ_type1; cd02201 443906005564 nucleotide binding site [chemical binding]; other site 443906005565 SulA interaction site; other site 443906005566 cell division protein FtsQ; Provisional; Region: PRK05529 443906005567 POTRA domain, FtsQ-type; Region: POTRA_1; pfam08478 443906005568 Cell division protein FtsQ; Region: FtsQ; pfam03799 443906005569 UDP-N-acetylmuramate--L-alanine ligase; Provisional; Region: murC; PRK00421 443906005570 Mur ligase family, catalytic domain; Region: Mur_ligase; pfam01225 443906005571 Mur ligase middle domain; Region: Mur_ligase_M; pfam08245 443906005572 Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875 443906005573 undecaprenyldiphospho-muramoylpentapeptide beta-N- acetylglucosaminyltransferase; Provisional; Region: murG; PRK00726 443906005574 MurG is an N-acetylglucosaminyltransferase, the last enzyme involved in the intracellular phase of peptidoglycan biosynthesis. It transfers N-acetyl-D-glucosamine (GlcNAc) from UDP-GlcNAc to the C4 hydroxyl of a lipid-linked N-acetylmuramoyl pentapeptide...; Region: GT1_MurG; cd03785 443906005575 active site 443906005576 homodimer interface [polypeptide binding]; other site 443906005577 Cell cycle protein; Region: FTSW_RODA_SPOVE; cl00511 443906005578 UDP-N-acetylmuramoyl-L-alanyl-D-glutamate synthetase; Provisional; Region: murD; PRK01438 443906005579 Mur ligase middle domain; Region: Mur_ligase_M; pfam08245 443906005580 Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875 443906005581 phospho-N-acetylmuramoyl-pentapeptide-transferase; Provisional; Region: mraY; PRK00108 443906005582 Phospho-N-acetylmuramoyl-pentapeptide-transferase (mraY) is an enzyme responsible for the formation of the first lipid intermediate in the synthesis of bacterial cell wall peptidoglycan. It catalyzes the formation of...; Region: GT_MraY; cd06852 443906005583 Mg++ binding site [ion binding]; other site 443906005584 putative catalytic motif [active] 443906005585 putative substrate binding site [chemical binding]; other site 443906005586 UDP-N-acetylmuramyl pentapeptide synthase [Cell envelope biogenesis, outer membrane]; Region: MurF; COG0770 443906005587 Mur ligase middle domain; Region: Mur_ligase_M; pfam08245 443906005588 Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875 443906005589 UDP-N-acetylmuramoylalanyl-D-glutamate--2, 6-diaminopimelate ligase; Provisional; Region: murE; PRK00139 443906005590 Mur ligase family, catalytic domain; Region: Mur_ligase; pfam01225 443906005591 Mur ligase middle domain; Region: Mur_ligase_M; pfam08245 443906005592 Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875 443906005593 Cell division protein FtsI/penicillin-binding protein 2 [Cell envelope biogenesis, outer membrane]; Region: FtsI; COG0768 443906005594 Penicillin-binding Protein dimerisation domain; Region: PBP_dimer; pfam03717 443906005595 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; pfam00905 443906005596 MraW methylase family; Region: Methyltransf_5; cl17771 443906005597 16S rRNA m(4)C1402 methyltranserfase; Provisional; Region: PRK00050 443906005598 cell division protein MraZ; Reviewed; Region: PRK00326 443906005599 MraZ protein; Region: MraZ; pfam02381 443906005600 MraZ protein; Region: MraZ; pfam02381 443906005601 Protein of unknown function (DUF3040); Region: DUF3040; pfam11239 443906005602 Isoprenoid Biosynthesis enzymes, Class 1; Region: Isoprenoid_Biosyn_C1; cl00210 443906005603 substrate binding pocket [chemical binding]; other site 443906005604 aspartate-rich region 1; other site 443906005605 Isoprenoid Biosynthesis enzymes, Class 1; Region: Isoprenoid_Biosyn_C1; cl00210 443906005606 substrate binding pocket [chemical binding]; other site 443906005607 aspartate-rich region 2; other site 443906005608 substrate-Mg2+ binding site; other site 443906005609 Helix-turn-helix domain; Region: HTH_17; cl17695 443906005610 Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118 443906005611 Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118 443906005612 FOG: LysM repeat [Cell envelope biogenesis, outer membrane]; Region: LytE; COG1388 443906005613 Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118 443906005614 Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220 443906005615 Catalytic domain of Protein Kinases; Region: PKc; cd00180 443906005616 active site 443906005617 ATP binding site [chemical binding]; other site 443906005618 substrate binding site [chemical binding]; other site 443906005619 activation loop (A-loop); other site 443906005620 PASTA domain of bacterial serine/threonine kinase pknB-like proteins. PknB is a member of a group of related transmembrane sensor kinases present in many gram positive bacteria, which has been shown to regulate cell shape in Mycobacterium tubercolosis; Region: PASTA_pknB; cd06577 443906005621 PASTA domain. This domain is found at the C-termini of several Penicillin-binding proteins (PBPs) and bacterial serine/threonine kinases. It is a small globular fold consisting of 3 beta-sheets and an alpha-helix. The name PASTA is derived from PBP and...; Region: PASTA; cl02768 443906005622 PASTA domain of bacterial serine/threonine kinase pknB-like proteins. PknB is a member of a group of related transmembrane sensor kinases present in many gram positive bacteria, which has been shown to regulate cell shape in Mycobacterium tubercolosis; Region: PASTA_pknB; cd06577 443906005623 PASTA domain of bacterial serine/threonine kinase pknB-like proteins. PknB is a member of a group of related transmembrane sensor kinases present in many gram positive bacteria, which has been shown to regulate cell shape in Mycobacterium tubercolosis; Region: PASTA_pknB; cd06577 443906005624 Class-II DAHP synthetase family; Region: DAHP_synth_2; pfam01474 443906005625 1-acyl-sn-glycerol-3-phosphate acyltransferase [Lipid metabolism]; Region: PlsC; COG0204 443906005626 Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: AGPAT-like; Region: LPLAT_AGPAT-like; cd07989 443906005627 putative acyl-acceptor binding pocket; other site 443906005628 ROK family protein (putative glucokinase); Region: ROK_glcA_fam; TIGR00744 443906005629 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cd00012 443906005630 nucleotide binding site [chemical binding]; other site 443906005631 Long-chain acyl-CoA synthetases (AMP-forming) [Lipid metabolism]; Region: FAA1; COG1022 443906005632 Long-chain fatty acid CoA synthetases and Bubblegum-like very long-chain fatty acid CoA synthetases; Region: VL_LC_FACS_like; cd05907 443906005633 acyl-activating enzyme (AAE) consensus motif; other site 443906005634 putative AMP binding site [chemical binding]; other site 443906005635 putative active site [active] 443906005636 putative CoA binding site [chemical binding]; other site 443906005637 Polypeptide or peptide deformylase; a family of metalloenzymes that catalyzes the removal of the N-terminal formyl group in a growing polypeptide chain following translation initiation during protein synthesis in prokaryotes. These enzymes utilize Fe(II)...; Region: Pep_deformylase; cd00487 443906005638 active site 443906005639 catalytic residues [active] 443906005640 metal binding site [ion binding]; metal-binding site 443906005641 mycothione reductase; Reviewed; Region: PRK07846 443906005642 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500 443906005643 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 443906005644 Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain; Region: Pyr_redox_dim; pfam02852 443906005645 pyruvate carboxylase; Reviewed; Region: PRK12999 443906005646 Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289 443906005647 ATP-grasp domain; Region: ATP-grasp_4; cl17255 443906005648 Biotin carboxylase C-terminal domain; Region: Biotin_carb_C; smart00878 443906005649 Pyruvate carboxylase and Transcarboxylase 5S, carboxyltransferase domain; Region: DRE_TIM_PC_TC_5S; cd07937 443906005650 active site 443906005651 catalytic residues [active] 443906005652 metal binding site [ion binding]; metal-binding site 443906005653 homodimer binding site [polypeptide binding]; other site 443906005654 The biotinyl-domain or biotin carboxyl carrier protein (BCCP) domain is present in all biotin-dependent enzymes, such as acetyl-CoA carboxylase, pyruvate carboxylase, propionyl-CoA carboxylase, methylcrotonyl-CoA carboxylase, geranyl-CoA carboxylase; Region: biotinyl_domain; cd06850 443906005655 carboxyltransferase (CT) interaction site; other site 443906005656 biotinylation site [posttranslational modification]; other site 443906005657 ATPases involved in chromosome partitioning [Cell division and chromosome partitioning]; Region: Soj; COG1192 443906005658 The Fer4_NifH superfamily contains a variety of proteins which share a common ATP-binding domain. Functionally, proteins in this superfamily use the energy from hydrolysis of NTP to transfer electron or ion; Region: Fer4_NifH; cl17203 443906005659 ParA and ParB of Caulobacter crescentus belong to a conserved family of bacterial proteins implicated in chromosome segregation. ParB binds to DNA sequences adjacent to the origin of replication and localizes to opposite cell poles shortly following the...; Region: ParA; cd02042 443906005660 Magnesium ion binding site [ion binding]; other site 443906005661 Helix-Turn-Helix DNA binding domain of transcription regulators from the MerR superfamily; Region: HTH_MerR-SF; cl02600 443906005662 Predicted transcriptional regulators [Transcription]; Region: SoxR; COG0789 443906005663 DNA binding residues [nucleotide binding] 443906005664 Helix-Turn-Helix DNA binding domain of MerR-like transcription regulators; Region: HTH_MerR-like; cd00592 443906005665 MerR HTH family regulatory protein; Region: MerR_1; pfam13411 443906005666 DNA binding residues [nucleotide binding] 443906005667 FOG: FHA domain [Signal transduction mechanisms]; Region: COG1716 443906005668 Forkhead associated domain (FHA); found in eukaryotic and prokaryotic proteins. Putative nuclear signalling domain. FHA domains may bind phosphothreonine, phosphoserine and sometimes phosphotyrosine. In eukaryotes, many FHA domain-containing proteins...; Region: FHA; cd00060 443906005669 phosphopeptide binding site; other site 443906005670 Sodium:dicarboxylate symporter family; Region: SDF; cl00573 443906005671 Na+/H+-dicarboxylate symporters [Energy production and conversion]; Region: GltP; COG1301 443906005672 Signal transduction histidine kinase regulating citrate/malate metabolism [Signal transduction mechanisms]; Region: CitA; COG3290 443906005673 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 443906005674 ATP binding site [chemical binding]; other site 443906005675 Mg2+ binding site [ion binding]; other site 443906005676 G-X-G motif; other site 443906005677 Response regulator of citrate/malate metabolism [Transcription / Signal transduction mechanisms]; Region: CitB; COG4565 443906005678 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 443906005679 active site 443906005680 phosphorylation site [posttranslational modification] 443906005681 intermolecular recognition site; other site 443906005682 dimerization interface [polypeptide binding]; other site 443906005683 Zinc metalloprotease (elastase) [Amino acid transport and metabolism]; Region: LasB; COG3227 443906005684 Peptidase M4 family includes thermolysin, protealysin, aureolysin and neutral protease; Region: M4_neutral_protease; cd09597 443906005685 active site 443906005686 Zn binding site [ion binding]; other site 443906005687 Protein of unknown function (DUF3097); Region: DUF3097; pfam11296 443906005688 Transcriptional regulators [Transcription]; Region: PurR; COG1609 443906005689 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 443906005690 DNA binding site [nucleotide binding] 443906005691 domain linker motif; other site 443906005692 Type 1 periplasmic binding fold superfamily; Region: Periplasmic_Binding_Protein_Type_1; cl10011 443906005693 Bacterial extracellular solute-binding protein; Region: SBP_bac_8; pfam13416 443906005694 hypothetical protein; Provisional; Region: PRK11622 443906005695 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 443906005696 putative PBP binding loops; other site 443906005697 dimer interface [polypeptide binding]; other site 443906005698 ABC-ATPase subunit interface; other site 443906005699 ABC-type spermidine/putrescine transport system, permease component II [Amino acid transport and metabolism]; Region: PotC; COG1177 443906005700 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 443906005701 dimer interface [polypeptide binding]; other site 443906005702 conserved gate region; other site 443906005703 putative PBP binding loops; other site 443906005704 ABC-ATPase subunit interface; other site 443906005705 ABC-type spermidine/putrescine transport systems, ATPase components [Amino acid transport and metabolism]; Region: PotA; COG3842 443906005706 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 443906005707 Walker A/P-loop; other site 443906005708 ATP binding site [chemical binding]; other site 443906005709 Q-loop/lid; other site 443906005710 ABC transporter signature motif; other site 443906005711 Walker B; other site 443906005712 D-loop; other site 443906005713 H-loop/switch region; other site 443906005714 Catalytic domain of phosphoinositide-specific phospholipase C-like phosphodiesterases superfamily; Region: PI-PLCc_GDPD_SF; cl14615 443906005715 Glycerophosphoryl diester phosphodiesterase family; Region: GDPD; pfam03009 443906005716 active site 443906005717 catalytic site [active] 443906005718 FIG, FBPase/IMPase/glpX-like domain. A superfamily of metal-dependent phosphatases with various substrates. Fructose-1,6-bisphospatase (both the major and the glpX-encoded variant) hydrolyze fructose-1,6,-bisphosphate to fructose-6-phosphate in...; Region: FIG; cl00289 443906005719 active site 443906005720 Nudix hydrolase is a superfamily of enzymes found in all three kingdoms of life, and it catalyzes the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+...; Region: Nudix_Hydrolase; cl00447 443906005721 nudix motif; other site 443906005722 alcohol dehydrogenase and quinone reductase-like medium chain degydrogenases/reductases; Region: MDR_like_2; cd05289 443906005723 NADPH:quinone reductase and related Zn-dependent oxidoreductases [Energy production and conversion / General function prediction only]; Region: Qor; COG0604 443906005724 putative NAD(P) binding site [chemical binding]; other site 443906005725 amine oxidase; Region: PLN02976 443906005726 amine oxidase; Region: PLN03000 443906005727 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 443906005728 RNA binding surface [nucleotide binding]; other site 443906005729 DnaJ domain or J-domain. DnaJ/Hsp40 (heat shock protein 40) proteins are highly conserved and play crucial roles in protein translation, folding, unfolding, translocation, and degradation. They act primarily by stimulating the ATPase activity of Hsp70s; Region: DnaJ; cd06257 443906005730 HSP70 interaction site [polypeptide binding]; other site 443906005731 Protein of unknown function (DUF3184); Region: DUF3184; pfam11380 443906005732 FAD binding domain in molybdopterin dehydrogenase; Region: FAD_binding_5; pfam00941 443906005733 xanthine dehydrogenase E subunit; Region: pucE; TIGR03198 443906005734 [2Fe-2S] binding domain; Region: Fer2_2; pfam01799 443906005735 Aerobic-type carbon monoxide dehydrogenase, large subunit CoxL/CutL homologs [Energy production and conversion]; Region: CoxL; COG1529 443906005736 Aldehyde oxidase and xanthine dehydrogenase, a/b hammerhead domain; Region: Ald_Xan_dh_C; smart01008 443906005737 Molybdopterin-binding domain of aldehyde dehydrogenase; Region: Ald_Xan_dh_C2; pfam02738 443906005738 amino acid transporter; Region: 2A0306; TIGR00909 443906005739 amino acid transporter; Region: 2A0306; TIGR00909 443906005740 XdhC and CoxI family; Region: XdhC_CoxI; pfam02625 443906005741 XdhC Rossmann domain; Region: XdhC_C; pfam13478 443906005742 guanine deaminase; Provisional; Region: PRK09228 443906005743 Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281 443906005744 active site 443906005745 PAP2_like_2 proteins. PAP2 is a super-family of phosphatases and haloperoxidases. This subgroup, which is specific to bacteria, lacks functional characterization and may act as a membrane-associated lipid phosphatase; Region: PAP2_like_2; cd03392 443906005746 active site 443906005747 Membrane-associated phospholipid phosphatase [Lipid metabolism]; Region: PgpB; COG0671 443906005748 GT_2_like_f is a subfamily of the glycosyltransferase family 2 (GT-2) with unknown function; Region: GT_2_like_f; cd04182 443906005749 Ligand binding site; other site 443906005750 metal-binding site 443906005751 Iron-sulfur cluster scaffold-like proteins; Region: IscU_like; cd06664 443906005752 active site 443906005753 Gamma-glutamyltransferase [Amino acid transport and metabolism]; Region: Ggt; cl08040 443906005754 Gamma-glutamyltranspeptidase; Region: G_glu_transpept; pfam01019 443906005755 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 443906005756 Major Facilitator Superfamily; Region: MFS_1; pfam07690 443906005757 putative substrate translocation pore; other site 443906005758 probable oxidoreductase, LLM family; Region: LLM_2I7G; TIGR03858 443906005759 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases [Energy production and conversion]; Region: COG2141 443906005760 SGNH_hydrolase subfamily, FeeA, FeeB and similar esterases/lipases. FeeA and FeeB are part of a biosynthetic gene cluster and may participate in the biosynthesis of long-chain N-acyltyrosines by providing saturated and unsaturated fatty acids, which it...; Region: FeeA_FeeB_like; cd01836 443906005761 active site 443906005762 catalytic triad [active] 443906005763 oxyanion hole [active] 443906005764 YjeF-related protein N-terminus; Region: YjeF_N; cl00318 443906005765 NADPH:quinone reductase and related Zn-dependent oxidoreductases [Energy production and conversion / General function prediction only]; Region: Qor; COG0604 443906005766 Zeta-crystallin with NADP-dependent quinone reductase activity (QOR); Region: zeta_crystallin; cd08253 443906005767 NAD(P) binding site [chemical binding]; other site 443906005768 Predicted metal-dependent hydrolase with the TIM-barrel fold [General function prediction only]; Region: COG1574 443906005769 Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281 443906005770 active site 443906005771 Putative FMN-binding domain; Region: FMN_bind_2; pfam04299 443906005772 Acyl-coenzyme A synthetases/AMP-(fatty) acid ligases [Lipid metabolism]; Region: Acs; COG0365 443906005773 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 443906005774 acyl-activating enzyme (AAE) consensus motif; other site 443906005775 AMP binding site [chemical binding]; other site 443906005776 active site 443906005777 CoA binding site [chemical binding]; other site 443906005778 Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596 443906005779 Putative lysophospholipase; Region: Hydrolase_4; pfam12146 443906005780 TAP-like protein; Region: Abhydrolase_4; pfam08386 443906005781 Transcriptional regulator [Transcription]; Region: LysR; COG0583 443906005782 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 443906005783 The MutT pyrophosphohydrolase is a prototypical Nudix hydrolase that catalyzes the hydrolysis of nucleoside and deoxynucleoside triphosphates (NTPs and dNTPs) by substitution at a beta-phosphorus to yield a nucleotide monophosphate (NMP) and inorganic...; Region: MutT_pyrophosphohydrolase; cd03425 443906005784 active site 443906005785 8-oxo-dGMP binding site [chemical binding]; other site 443906005786 nudix motif; other site 443906005787 metal binding site [ion binding]; metal-binding site 443906005788 Alpha/beta hydrolase family; Region: Abhydrolase_5; pfam12695 443906005789 Prolyl oligopeptidase family; Region: Peptidase_S9; pfam00326 443906005790 Protein of unknown function (DUF1212); Region: DUF1212; pfam06738 443906005791 M20 Peptidase Aminoacylase 1 subfamily; Region: M20_Acy1_like6; cd05664 443906005792 Metal-dependent amidase/aminoacylase/carboxypeptidase [General function prediction only]; Region: AbgB; COG1473 443906005793 metal binding site [ion binding]; metal-binding site 443906005794 putative dimer interface [polypeptide binding]; other site 443906005795 Integrase core domain; Region: rve_3; pfam13683 443906005796 Homeodomain-like domain; Region: HTH_23; cl17451 443906005797 Winged helix-turn helix; Region: HTH_29; pfam13551 443906005798 Predicted membrane protein [Function unknown]; Region: COG4270 443906005799 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 443906005800 sulfur acquisition oxidoreductase, SfnB family; Region: sulfur_SfnB; TIGR04022 443906005801 active site 443906005802 nitrilotriacetate monoxygenase oxidizes nitrilotriacetate utilizing reduced flavin mononucleotide (FMNH2) and oxygen. The FMNH2 is provided by an NADH:flavin mononucleotide (FMN) oxidorductase that uses NADH to reduce FMN to FMNH2; Region: Nitrilotriacetate_monoxgenase; cd01095 443906005803 FMN-dependent oxidoreductase, nitrilotriacetate monooxygenase family; Region: FMN_nitrolo; TIGR03860 443906005804 active site 443906005805 non-prolyl cis peptide bond; other site 443906005806 V8-like Glu-specific endopeptidase [Amino acid transport and metabolism]; Region: COG3591 443906005807 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 443906005808 metabolite-proton symporter; Region: 2A0106; TIGR00883 443906005809 putative substrate translocation pore; other site 443906005810 choline dehydrogenase; Validated; Region: PRK02106 443906005811 GMC oxidoreductase; Region: GMC_oxred_C; pfam05199 443906005812 NAD(P)+-dependent aldehyde dehydrogenase superfamily; Region: ALDH-SF; cl11961 443906005813 Aldehyde dehydrogenase family; Region: Aldedh; pfam00171 443906005814 NAD(P) binding site [chemical binding]; other site 443906005815 catalytic residues [active] 443906005816 BCCT family transporter; Region: BCCT; cl00569 443906005817 Glyoxalase-like domain; Region: Glyoxalase_3; pfam13468 443906005818 alkylhydroperoxidase domain protein, Avi_7169 family; Region: perox_Avi_7169; TIGR04030 443906005819 uncharacterized peroxidase-related enzyme; Region: peroxid_rel; TIGR01926 443906005820 CMD domain protein, Avi_7170 family; Region: CMD_Avi_7170; TIGR04029 443906005821 putative FMN-dependent luciferase-like monooxygenase, KPN_01858 family; Region: LLM_KPN_01858; TIGR04027 443906005822 Flavin-utilizing monoxygenases; Region: Flavin_utilizing_monoxygenases; cl07892 443906005823 ATPase components of various ABC-type transport systems, contain duplicated ATPase [General function prediction only]; Region: COG1123 443906005824 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 443906005825 Walker A/P-loop; other site 443906005826 ATP binding site [chemical binding]; other site 443906005827 Q-loop/lid; other site 443906005828 ABC transporter signature motif; other site 443906005829 Walker B; other site 443906005830 D-loop; other site 443906005831 H-loop/switch region; other site 443906005832 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 443906005833 Walker A/P-loop; other site 443906005834 ATP binding site [chemical binding]; other site 443906005835 Q-loop/lid; other site 443906005836 ABC transporter signature motif; other site 443906005837 Walker B; other site 443906005838 D-loop; other site 443906005839 H-loop/switch region; other site 443906005840 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppC; COG1173 443906005841 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 443906005842 putative PBP binding loops; other site 443906005843 ABC-ATPase subunit interface; other site 443906005844 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppB; COG0601 443906005845 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 443906005846 dimer interface [polypeptide binding]; other site 443906005847 conserved gate region; other site 443906005848 putative PBP binding loops; other site 443906005849 ABC-ATPase subunit interface; other site 443906005850 ABC-type dipeptide transport system, periplasmic component [Amino acid transport and metabolism]; Region: DdpA; COG0747 443906005851 The substrate-binding component of an uncharacterized ABC-type nickel/dipeptide/oligopeptide-like import system contains the type 2 periplasmic binding fold; Region: PBP2_NikA_DppA_OppA_like_15; cd08492 443906005852 Acetyltransferase (GNAT) domain; Region: Acetyltransf_10; pfam13673 443906005853 Acetyltransferase (GNAT) family; Region: Acetyltransf_1; pfam00583 443906005854 Coenzyme A binding pocket [chemical binding]; other site 443906005855 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4200 443906005856 ABC-2 family transporter protein; Region: ABC2_membrane_4; pfam12730 443906005857 ABC-2 family transporter protein; Region: ABC2_membrane_4; pfam12730 443906005858 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4200 443906005859 ABC-type multidrug transport system, ATPase component [Defense mechanisms]; Region: CcmA; COG1131 443906005860 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 443906005861 Walker A/P-loop; other site 443906005862 ATP binding site [chemical binding]; other site 443906005863 Q-loop/lid; other site 443906005864 ABC transporter signature motif; other site 443906005865 Walker B; other site 443906005866 D-loop; other site 443906005867 H-loop/switch region; other site 443906005868 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 443906005869 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 443906005870 active site 443906005871 phosphorylation site [posttranslational modification] 443906005872 intermolecular recognition site; other site 443906005873 dimerization interface [polypeptide binding]; other site 443906005874 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 443906005875 DNA binding residues [nucleotide binding] 443906005876 dimerization interface [polypeptide binding]; other site 443906005877 Histidine kinase; Region: HisKA_3; pfam07730 443906005878 Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase; Region: HATPase_c; pfam02518 443906005879 ATP binding site [chemical binding]; other site 443906005880 Mg2+ binding site [ion binding]; other site 443906005881 G-X-G motif; other site 443906005882 type 2 lantibiotic biosynthesis protein LanM; Region: lanti_2_LanM; TIGR03897 443906005883 Domain of unknown function (DUF4135); Region: DUF4135; pfam13575 443906005884 LanC-like proteins. LanC is the cyclase enzyme of the lanthionine synthetase. Lanthionine is a lantibiotic, a unique class of peptide antibiotics. They are ribosomally synthesized as a precursor peptide and then post-translationally modified to contain...; Region: LanC_like; cl04955 443906005885 active site 443906005886 zinc binding site [ion binding]; other site 443906005887 Protein of unknown function (DUF2510); Region: DUF2510; pfam10708 443906005888 PASTA domain of bacterial serine/threonine kinase pknB-like proteins. PknB is a member of a group of related transmembrane sensor kinases present in many gram positive bacteria, which has been shown to regulate cell shape in Mycobacterium tubercolosis; Region: PASTA_pknB; cd06577 443906005889 Very Short Patch Repair (Vsr) Endonuclease. Endonucleases in DNA repair that recognize damaged DNA and cleave the phosphodiester backbone. Vsr endonucleases have a common endonuclease topology that has been tailored for recognition of TG mismatches; Region: Vsr; cd00221 443906005890 additional DNA contacts [nucleotide binding]; other site 443906005891 mismatch recognition site; other site 443906005892 active site 443906005893 zinc binding site [ion binding]; other site 443906005894 DNA intercalation site [nucleotide binding]; other site 443906005895 Metallo-beta-lactamase superfamily; Region: Lactamase_B; smart00849 443906005896 sulfur acquisition oxidoreductase, SfnB family; Region: sulfur_SfnB; TIGR04022 443906005897 Dibenzothiophene (DBT) desulfurization enzyme C; Region: DszC; cd01163 443906005898 Flavin binding site [chemical binding]; other site 443906005899 GTP-binding protein Der; Reviewed; Region: PRK03003 443906005900 EngA1 GTPase contains the first domain of EngA; Region: EngA1; cd01894 443906005901 G1 box; other site 443906005902 GTP/Mg2+ binding site [chemical binding]; other site 443906005903 Switch I region; other site 443906005904 G2 box; other site 443906005905 Switch II region; other site 443906005906 G3 box; other site 443906005907 G4 box; other site 443906005908 G5 box; other site 443906005909 EngA2 GTPase contains the second domain of EngA; Region: EngA2; cd01895 443906005910 G1 box; other site 443906005911 GTP/Mg2+ binding site [chemical binding]; other site 443906005912 Switch I region; other site 443906005913 G2 box; other site 443906005914 G3 box; other site 443906005915 Switch II region; other site 443906005916 G4 box; other site 443906005917 G5 box; other site 443906005918 cytidylate kinase; Provisional; Region: cmk; PRK00023 443906005919 Cytidine monophosphate kinase (CMPK) catalyzes the reversible phosphorylation of cytidine monophosphate (CMP) to produce cytidine diphosphate (CDP), using ATP as the preferred phosphoryl donor; Region: CMPK; cd02020 443906005920 CMP-binding site; other site 443906005921 The sites determining sugar specificity; other site 443906005922 prephenate dehydrogenase; Validated; Region: PRK06545 443906005923 prephenate dehydrogenase; Validated; Region: PRK08507 443906005924 ACT domains are commonly involved in specifically binding an amino acid or other small ligand leading to regulation of the enzyme; Region: ACT; cl09141 443906005925 16S rRNA uridine-516 pseudouridylate synthase and related pseudouridylate synthases [Translation, ribosomal structure and biogenesis]; Region: RsuA; COG1187 443906005926 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 443906005927 RNA binding surface [nucleotide binding]; other site 443906005928 Pseudouridine synthases, RsuA subfamily; Region: PseudoU_synth_RsuA_like; cd02870 443906005929 active site 443906005930 Putative transcriptional regulators (Ypuh-like); Region: DUF387; pfam04079 443906005931 Rec8/ScpA/Scc1-like protein (kleisin family) [Replication, recombination, and repair]; Region: scpA; COG1354 443906005932 ATPases involved in chromosome partitioning [Cell division and chromosome partitioning]; Region: Soj; COG1192 443906005933 ParA and ParB of Caulobacter crescentus belong to a conserved family of bacterial proteins implicated in chromosome segregation. ParB binds to DNA sequences adjacent to the origin of replication and localizes to opposite cell poles shortly following the...; Region: ParA; cd02042 443906005934 P-loop; other site 443906005935 Magnesium ion binding site [ion binding]; other site 443906005936 ParA and ParB of Caulobacter crescentus belong to a conserved family of bacterial proteins implicated in chromosome segregation. ParB binds to DNA sequences adjacent to the origin of replication and localizes to opposite cell poles shortly following the...; Region: ParA; cd02042 443906005937 Magnesium ion binding site [ion binding]; other site 443906005938 site-specific tyrosine recombinase XerD; Reviewed; Region: xerD; PRK00283 443906005939 DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213 443906005940 active site 443906005941 DNA binding site [nucleotide binding] 443906005942 Int/Topo IB signature motif; other site 443906005943 ADP-ribose pyrophosphatase (ADPRase) catalyzes the hydrolysis of ADP-ribose and a variety of additional ADP-sugar conjugates to AMP and ribose-5-phosphate. Like other members of the Nudix hydrolase superfamily, it requires a divalent cation, such as Mg2+; Region: ADPRase_NUDT5; cd03424 443906005944 dimer interface [polypeptide binding]; other site 443906005945 ADP-ribose binding site [chemical binding]; other site 443906005946 active site 443906005947 nudix motif; other site 443906005948 metal binding site [ion binding]; metal-binding site 443906005949 CTP synthetase; Validated; Region: pyrG; PRK05380 443906005950 CTP synthetase (CTPs) is a two-domain protein, which consists of an N-terminal synthetase domain and C-terminal glutaminase domain. The enzymes hydrolyze the amide bond of glutamine to ammonia and glutamate at the glutaminase domains and transfer nascent...; Region: CTGs; cd03113 443906005951 Catalytic site [active] 443906005952 active site 443906005953 UTP binding site [chemical binding]; other site 443906005954 Type 1 glutamine amidotransferase (GATase1) domain found in Cytidine Triphosphate Synthetase; Region: GATase1_CTP_Synthase; cd01746 443906005955 active site 443906005956 putative oxyanion hole; other site 443906005957 catalytic triad [active] 443906005958 ATPase involved in DNA repair [DNA replication, recombination, and repair]; Region: RecN; COG0497 443906005959 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 443906005960 Walker A/P-loop; other site 443906005961 ATP binding site [chemical binding]; other site 443906005962 Q-loop/lid; other site 443906005963 ATP-binding cassette domain of RecN; Region: ABC_RecN; cd03241 443906005964 ABC transporter signature motif; other site 443906005965 Walker B; other site 443906005966 D-loop; other site 443906005967 H-loop/switch region; other site 443906005968 inorganic polyphosphate/ATP-NAD kinase; Provisional; Region: ppnK; PRK03372 443906005969 inorganic polyphosphate/ATP-NAD kinase; Provisional; Region: ppnK; PRK02231 443906005970 Predicted rRNA methylase [Translation, ribosomal structure and biogenesis]; Region: COG1189 443906005971 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 443906005972 RNA binding surface [nucleotide binding]; other site 443906005973 FtsJ-like methyltransferase; Region: FtsJ; pfam01728 443906005974 Predicted sugar phosphatases of the HAD superfamily [Carbohydrate transport and metabolism]; Region: NagD; COG0647 443906005975 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 443906005976 active site 443906005977 motif I; other site 443906005978 motif II; other site 443906005979 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 443906005980 tyrosyl-tRNA synthetase; Validated; Region: PRK05912 443906005981 catalytic core domain of tyrosinyl-tRNA synthetase; Region: TyrRS_core; cd00805 443906005982 active site 443906005983 HIGH motif; other site 443906005984 dimer interface [polypeptide binding]; other site 443906005985 KMSKS motif; other site 443906005986 Alkyladenine DNA glycosylase catalyzes the first step in base excision repair; Region: AAG; cd00540 443906005987 active site 443906005988 DNA binding site [nucleotide binding] 443906005989 argininosuccinate lyase; Provisional; Region: PRK00855 443906005990 Argininosuccinate lyase (argininosuccinase, ASAL); Region: Argininosuccinate_lyase; cd01359 443906005991 active sites [active] 443906005992 tetramer interface [polypeptide binding]; other site 443906005993 argininosuccinate synthase; Provisional; Region: PRK13820 443906005994 Argininosuccinate synthase. The Argininosuccinate synthase is a urea cycle enzyme that catalyzes the penultimate step in arginine biosynthesis: the ATP-dependent ligation of citrulline to aspartate to form argininosuccinate, AMP and pyrophosphate . In...; Region: Argininosuccinate_Synthase; cd01999 443906005995 ANP binding site [chemical binding]; other site 443906005996 Substrate Binding Site II [chemical binding]; other site 443906005997 Substrate Binding Site I [chemical binding]; other site 443906005998 ornithine carbamoyltransferase; Provisional; Region: PRK00779 443906005999 Aspartate/ornithine carbamoyltransferase, carbamoyl-P binding domain; Region: OTCace_N; pfam02729 443906006000 Aspartate/ornithine carbamoyltransferase, Asp/Orn binding domain; Region: OTCace; pfam00185 443906006001 acetylornithine aminotransferase; Provisional; Region: argD; PRK03244 443906006002 Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610 443906006003 inhibitor-cofactor binding pocket; inhibition site 443906006004 pyridoxal 5'-phosphate binding site [chemical binding]; other site 443906006005 catalytic residue [active] 443906006006 AAK_NAGK-C: N-Acetyl-L-glutamate kinase - cyclic (NAGK-C) catalyzes the phosphorylation of the gamma-COOH group of N-acetyl-L-glutamate (NAG) by ATP in the second step of arginine biosynthesis found in some bacteria and photosynthetic organisms using the...; Region: AAK_NAGK-C; cd04250 443906006007 feedback inhibition sensing region; other site 443906006008 homohexameric interface [polypeptide binding]; other site 443906006009 nucleotide binding site [chemical binding]; other site 443906006010 N-acetyl-L-glutamate binding site [chemical binding]; other site 443906006011 Ornithine acetyltransferase (OAT) family; also referred to as ArgJ. OAT catalyzes the first and fifth steps in arginine biosynthesis, coupling acetylation of glutamate with deacetylation of N-acetylornithine, which allows recycling of the acetyl group in...; Region: OAT; cd02152 443906006012 heterotetramer interface [polypeptide binding]; other site 443906006013 active site pocket [active] 443906006014 cleavage site 443906006015 N-acetyl-gamma-glutamyl-phosphate reductase; Validated; Region: argC; PRK00436 443906006016 Semialdehyde dehydrogenase, NAD binding domain; Region: Semialdhyde_dh; smart00859 443906006017 phenylalanyl-tRNA synthetase subunit beta; Reviewed; Region: pheT; PRK00629 443906006018 tRNA-binding-domain-containing prokaryotic phenylalanly tRNA synthetase (PheRS) beta chain. PheRS aminoacylate phenylalanine transfer RNAs (tRNAphe). PheRSs belong structurally to class II aminoacyl tRNA synthetases (aaRSs) but, as they aminoacylate...; Region: tRNA_bind_bactPheRS; cd02796 443906006019 putative tRNA-binding site [nucleotide binding]; other site 443906006020 B3/4 domain; Region: B3_4; pfam03483 443906006021 tRNA synthetase B5 domain; Region: B5; smart00874 443906006022 Phenylalanyl-tRNA synthetase (PheRS) beta chain core domain. PheRS belongs to class II aminoacyl-tRNA synthetases (aaRS) based upon its structure. While class II aaRSs generally aminoacylate the 3'-OH ribose of the appropriate tRNA, PheRS is an...; Region: PheRS_beta_core; cd00769 443906006023 dimer interface [polypeptide binding]; other site 443906006024 motif 1; other site 443906006025 motif 3; other site 443906006026 motif 2; other site 443906006027 Ferredoxin-fold anticodon binding domain; Region: FDX-ACB; pfam03147 443906006028 phenylalanyl-tRNA synthetase subunit alpha; Validated; Region: pheS; PRK00488 443906006029 Aminoacyl tRNA synthetase class II, N-terminal domain; Region: Phe_tRNA-synt_N; pfam02912 443906006030 Phenylalanyl-tRNA synthetase (PheRS) alpha chain catalytic core domain. PheRS belongs to class II aminoacyl-tRNA synthetases (aaRS) based upon its structure and the presence of three characteristic sequence motifs. This domain is primarily responsible...; Region: PheRS_alpha_core; cd00496 443906006031 dimer interface [polypeptide binding]; other site 443906006032 motif 1; other site 443906006033 active site 443906006034 motif 2; other site 443906006035 motif 3; other site 443906006036 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 443906006037 dimer interface [polypeptide binding]; other site 443906006038 conserved gate region; other site 443906006039 putative PBP binding loops; other site 443906006040 ABC-ATPase subunit interface; other site 443906006041 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 443906006042 dimer interface [polypeptide binding]; other site 443906006043 conserved gate region; other site 443906006044 ABC-ATPase subunit interface; other site 443906006045 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 443906006046 Bacterial extracellular solute-binding proteins, family 3; Region: SBP_bac_3; pfam00497 443906006047 substrate binding pocket [chemical binding]; other site 443906006048 membrane-bound complex binding site; other site 443906006049 hinge residues; other site 443906006050 ABC-type polar amino acid transport system, ATPase component [Amino acid transport and metabolism]; Region: GlnQ; COG1126 443906006051 ATP-binding cassette domain of the histidine and glutamine transporters; Region: ABC_HisP_GlnQ; cd03262 443906006052 Walker A/P-loop; other site 443906006053 ATP binding site [chemical binding]; other site 443906006054 Q-loop/lid; other site 443906006055 ABC transporter signature motif; other site 443906006056 Walker B; other site 443906006057 D-loop; other site 443906006058 H-loop/switch region; other site 443906006059 rRNA methylases [Translation, ribosomal structure and biogenesis]; Region: SpoU; COG0566 443906006060 RNA 2'-O ribose methyltransferase substrate binding; Region: SpoU_sub_bind; smart00967 443906006061 SpoU rRNA Methylase family; Region: SpoU_methylase; pfam00588 443906006062 Ribosomal protein L20; Region: Ribosomal_L20; cd07026 443906006063 23S rRNA binding site [nucleotide binding]; other site 443906006064 L21 binding site [polypeptide binding]; other site 443906006065 L13 binding site [polypeptide binding]; other site 443906006066 50S ribosomal protein L35; Reviewed; Region: rpmI; PRK00172 443906006067 translation initiation factor IF-3; Reviewed; Region: infC; PRK00028 443906006068 Translation initiation factor IF-3, N-terminal domain; Region: IF3_N; pfam05198 443906006069 Translation initiation factor IF-3, C-terminal domain; Region: IF3_C; pfam00707 443906006070 HisA. Phosphoribosylformimino-5-aminoimidazole carboxamide ribonucleotide (ProFAR) isomerase catalyzes the fourth step in histidine biosynthesis, an isomerisation of the aminoaldose moiety of ProFAR to the aminoketose of PRFAR (N-(5'-phospho-D-1...; Region: HisA; cd04732 443906006071 phosphoribosylformimino-5-aminoimidazole carboxamide ribotide isomerase; Region: TIGR00007 443906006072 catalytic residues [active] 443906006073 imidazole glycerol phosphate synthase subunit HisH; Provisional; Region: hisH; PRK13146 443906006074 Type 1 glutamine amidotransferase (GATase1) domain found in imidazole glycerol phosphate synthase (IGPS); Region: GATase1_IGP_Synthase; cd01748 443906006075 putative active site [active] 443906006076 oxyanion strand; other site 443906006077 catalytic triad [active] 443906006078 Imidazoleglycerol-phosphate dehydratase; Region: IGPD; cd07914 443906006079 putative active site pocket [active] 443906006080 4-fold oligomerization interface [polypeptide binding]; other site 443906006081 metal binding residues [ion binding]; metal-binding site 443906006082 3-fold/trimer interface [polypeptide binding]; other site 443906006083 Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cl00107 443906006084 LexA repressor; Validated; Region: PRK00215 443906006085 LexA DNA binding domain; Region: LexA_DNA_bind; pfam01726 443906006086 Peptidase S24 LexA-like proteins are involved in the SOS response leading to the repair of single-stranded DNA within the bacterial cell. This family includes: the lambda repressor CI/C2 family and related bacterial prophage repressor proteins; LexA (EC...; Region: S24_LexA-like; cd06529 443906006087 Catalytic site [active] 443906006088 GTP-binding protein HflX; Region: GTP_HflX; TIGR03156 443906006089 GTP-binding GTPase N-terminal; Region: GTP-bdg_N; pfam13167 443906006090 HflX GTPase family; Region: HflX; cd01878 443906006091 G1 box; other site 443906006092 GTP/Mg2+ binding site [chemical binding]; other site 443906006093 Switch I region; other site 443906006094 G2 box; other site 443906006095 G3 box; other site 443906006096 Switch II region; other site 443906006097 G4 box; other site 443906006098 G5 box; other site 443906006099 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 443906006100 S-adenosylmethionine binding site [chemical binding]; other site 443906006101 diaminopimelate epimerase; Provisional; Region: dapF; PRK00450 443906006102 Diaminopimelate epimerase; Region: DAP_epimerase; pfam01678 443906006103 Diaminopimelate epimerase; Region: DAP_epimerase; pfam01678 443906006104 tRNA delta(2)-isopentenylpyrophosphate transferase; Reviewed; Region: miaA; PRK00091 443906006105 tRNA delta(2)-isopentenylpyrophosphate transferase [Translation, ribosomal structure and biogenesis]; Region: MiaA; COG0324 443906006106 (dimethylallyl)adenosine tRNA methylthiotransferase; Provisional; Region: PRK14326 443906006107 Uncharacterized protein family UPF0004; Region: UPF0004; pfam00919 443906006108 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 443906006109 FeS/SAM binding site; other site 443906006110 TRAM domain; Region: TRAM; cl01282 443906006111 RecX family; Region: RecX; pfam02631 443906006112 recombinase A; Provisional; Region: recA; PRK09354 443906006113 RecA is a bacterial enzyme which has roles in homologous recombination, DNA repair, and the induction of the SOS response. RecA couples ATP hydrolysis to DNA strand exchange; Region: recA; cd00983 443906006114 hexamer interface [polypeptide binding]; other site 443906006115 Walker A motif; other site 443906006116 ATP binding site [chemical binding]; other site 443906006117 Walker B motif; other site 443906006118 Protein of unknown function (DUF3046); Region: DUF3046; pfam11248 443906006119 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 443906006120 non-specific DNA binding site [nucleotide binding]; other site 443906006121 salt bridge; other site 443906006122 sequence-specific DNA binding site [nucleotide binding]; other site 443906006123 Competence-damaged protein; Region: CinA; pfam02464 443906006124 CDP-alcohol phosphatidyltransferase; Region: CDP-OH_P_transf; cl00453 443906006125 Predicted permeases [General function prediction only]; Region: COG0730 443906006126 Domain of unknown function (DUF4117); Region: DUF4117; pfam13491 443906006127 DNA segregation ATPase FtsK/SpoIIIE and related proteins [Cell division and chromosome partitioning]; Region: FtsK; COG1674 443906006128 FtsK/SpoIIIE family; Region: FtsK_SpoIIIE; pfam01580 443906006129 Ftsk gamma domain; Region: Ftsk_gamma; pfam09397 443906006130 FtsX-like permease family; Region: FtsX; pfam02687 443906006131 ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136 443906006132 ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255 443906006133 Walker A/P-loop; other site 443906006134 ATP binding site [chemical binding]; other site 443906006135 Q-loop/lid; other site 443906006136 ABC transporter signature motif; other site 443906006137 Walker B; other site 443906006138 D-loop; other site 443906006139 H-loop/switch region; other site 443906006140 Pyruvate/2-oxoglutarate dehydrogenase complex, dihydrolipoamide acyltransferase (E2) component, and related enzymes [Energy production and conversion]; Region: AceF; COG0508 443906006141 RND family efflux transporter, MFP subunit; Region: RND_mfp; TIGR01730 443906006142 mRNA degradation ribonucleases J1/J2 (metallo-beta-lactamase superfamily) [Translation, ribosomal structure and biogenesis; Replication, recombination and repair]; Region: COG0595 443906006143 Metallo-beta-lactamase superfamily; Region: Lactamase_B; smart00849 443906006144 RNA-metabolising metallo-beta-lactamase; Region: RMMBL; pfam07521 443906006145 Dihydrodipicolinate synthase (DHDPS); Region: DHDPS; cd00950 443906006146 Dihydrodipicolinate synthase/N-acetylneuraminate lyase [Amino acid transport and metabolism / Cell envelope biogenesis, outer membrane]; Region: DapA; COG0329 443906006147 dimer interface [polypeptide binding]; other site 443906006148 active site 443906006149 catalytic residue [active] 443906006150 FAD-dependent thymidylate synthase; Reviewed; Region: thyX; PRK00847 443906006151 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 443906006152 Predicted nucleoside-diphosphate sugar epimerase [General function prediction only]; Region: COG1090 443906006153 NAD(P) binding site [chemical binding]; other site 443906006154 active site 443906006155 dihydrodipicolinate reductase; Provisional; Region: PRK00048 443906006156 Dihydrodipicolinate reductase, N-terminus; Region: DapB_N; pfam01113 443906006157 Dihydrodipicolinate reductase, C-terminus; Region: DapB_C; pfam05173 443906006158 Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067 443906006159 catalytic core [active] 443906006160 Predicted Zn-dependent peptidases [General function prediction only]; Region: PqqL; COG0612 443906006161 Insulinase (Peptidase family M16); Region: Peptidase_M16; pfam00675 443906006162 Peptidase M16 inactive domain; Region: Peptidase_M16_C; pfam05193 443906006163 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 443906006164 Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248 443906006165 active site 443906006166 catalytic tetrad [active] 443906006167 PhosphatidylEthanolamine-Binding Protein (PEBP) domain present in bacteria and archaea; Region: PEBP_bact_arch; cd00865 443906006168 substrate binding site [chemical binding]; other site 443906006169 guanosine pentaphosphate synthetase I/polynucleotide phosphorylase; Region: pppGpp_PNP; TIGR02696 443906006170 RNase PH-like 3'-5' exoribonucleases; Region: RNase_PH; cl03114 443906006171 oligomer interface [polypeptide binding]; other site 443906006172 RNA binding site [nucleotide binding]; other site 443906006173 Polyribonucleotide nucleotidyltransferase, RNA binding domain; Region: PNPase; pfam03726 443906006174 Polyribonucleotide nucleotidyltransferase, repeat 2; Region: RNase_PH_PNPase_2; cd11364 443906006175 RNase E interface [polypeptide binding]; other site 443906006176 trimer interface [polypeptide binding]; other site 443906006177 active site 443906006178 Polynucleotide phosphorylase (PNPase) K homology RNA-binding domain (KH). PNPase is a polyribonucleotide nucleotidyl transferase that degrades mRNA in prokaryotes and plant chloroplasts. The C-terminal region of PNPase contains domains homologous to...; Region: PNPase_KH; cd02393 443906006179 putative nucleic acid binding region [nucleotide binding]; other site 443906006180 G-X-X-G motif; other site 443906006181 S1_PNPase: Polynucleotide phosphorylase (PNPase), ), S1-like RNA-binding domain. PNPase is a polyribonucleotide nucleotidyl transferase that degrades mRNA. It is a trimeric multidomain protein. The C-terminus contains the S1 domain which binds ssRNA; Region: S1_PNPase; cd04472 443906006182 RNA binding site [nucleotide binding]; other site 443906006183 domain interface; other site 443906006184 Ribosomal protein S15 (prokaryotic)_S13 (eukaryotic) binds the central domain of 16S rRNA and is required for assembly of the small ribosomal subunit and for intersubunit association, thus representing a key element in the assembly of the whole ribosome; Region: Ribosomal_S15p_S13e; cd00353 443906006185 16S/18S rRNA binding site [nucleotide binding]; other site 443906006186 S13e-L30e interaction site [polypeptide binding]; other site 443906006187 25S rRNA binding site [nucleotide binding]; other site 443906006188 enterobactin exporter EntS; Provisional; Region: PRK10489 443906006189 Protein of unknown function (DUF1524); Region: DUF1524; pfam07510 443906006190 Di- and tricarboxylate transporters [Inorganic ion transport and metabolism]; Region: CitT; COG0471 443906006191 Anion permease ArsB/NhaD. These permeases have been shown to translocate sodium, arsenate, antimonite, sulfate and organic anions across biological membranes in all three kingdoms of life. A typical anion permease contains 8-13 transmembrane helices...; Region: ArsB_NhaD_permease; cd00625 443906006192 transmembrane helices; other site 443906006193 Superfamily I DNA and RNA helicases [General function prediction only]; Region: COG3973 443906006194 Part of AAA domain; Region: AAA_19; pfam13245 443906006195 Family description; Region: UvrD_C_2; pfam13538 443906006196 VanZ like family; Region: VanZ; pfam04892 443906006197 CIMS - Cobalamine-independent methonine synthase, or MetE, C-terminal domain_like. Many members have been characterized as 5-methyltetrahydropteroyltriglutamate-homocysteine methyltransferases, EC:2.1.1.14, mostly from bacteria and plants. This enzyme...; Region: CIMS_C_terminal_like; cd03311 443906006198 substrate binding site [chemical binding]; other site 443906006199 THF binding site; other site 443906006200 zinc-binding site [ion binding]; other site 443906006201 adenine phosphoribosyltransferase; Provisional; Region: PRK02304 443906006202 Peptidase M50B-like; Region: Peptidase_M50B; pfam13398 443906006203 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 443906006204 Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248 443906006205 active site 443906006206 catalytic tetrad [active] 443906006207 Signal peptidase (SPase) II; Region: Peptidase_A8; pfam01252 443906006208 A type 1 glutamine amidotransferase (GATase1)-like domain found in PfpI from Pyrococcus furiosus; Region: GATase1_PfpI_like; cd03134 443906006209 intracellular protease, PfpI family; Region: PfpI; TIGR01382 443906006210 proposed catalytic triad [active] 443906006211 conserved cys residue [active] 443906006212 SMP-30/Gluconolaconase/LRE-like region; Region: SGL; pfam08450 443906006213 DNA-binding ferritin-like protein (oxidative damage protectant) [Inorganic ion transport and metabolism]; Region: Dps; COG0783 443906006214 DPS protein, ferritin-like diiron-binding domain; Region: DPS; cd01043 443906006215 dimerization interface [polypeptide binding]; other site 443906006216 DPS ferroxidase diiron center [ion binding]; other site 443906006217 ion pore; other site 443906006218 3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05653 443906006219 classical (c) SDRs; Region: SDR_c; cd05233 443906006220 NAD(P) binding site [chemical binding]; other site 443906006221 active site 443906006222 Protein of unknown function (DUF2945); Region: DUF2945; pfam11160 443906006223 Histidine kinase; Region: HisKA_3; pfam07730 443906006224 Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase; Region: HATPase_c; pfam02518 443906006225 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 443906006226 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 443906006227 active site 443906006228 phosphorylation site [posttranslational modification] 443906006229 intermolecular recognition site; other site 443906006230 dimerization interface [polypeptide binding]; other site 443906006231 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 443906006232 DNA binding residues [nucleotide binding] 443906006233 dimerization interface [polypeptide binding]; other site 443906006234 D-Ala-D-Ala carboxypeptidase 3 (S13) family; Region: Peptidase_S13; cl17429 443906006235 D-alanyl-D-alanine carboxypeptidase, serine-type, PBP4 family; Region: PBP4; TIGR00666 443906006236 Site-specific recombinases, DNA invertase Pin homologs [DNA replication, recombination, and repair]; Region: PinR; COG1961 443906006237 Serine Recombinase (SR) family, Resolvase and Invertase subfamily, catalytic domain; members contain a C-terminal DNA binding domain. Serine recombinases catalyze site-specific recombination of DNA molecules by a concerted, four-strand cleavage and...; Region: SR_ResInv; cd03768 443906006238 catalytic residues [active] 443906006239 catalytic nucleophile [active] 443906006240 Protein of unknown function (DUF3072); Region: DUF3072; pfam11272 443906006241 Protease prsW family; Region: PrsW-protease; pfam13367 443906006242 FAD binding domain; Region: FAD_binding_4; pfam01565 443906006243 glycolate oxidase, subunit GlcD; Region: glcD; TIGR00387 443906006244 AlkA N-terminal domain; Region: AlkA_N; pfam06029 443906006245 3-methyl-adenine DNA glycosylase II; Provisional; Region: PRK10308 443906006246 endonuclease III; includes endonuclease III (DNA-(apurinic or apyrimidinic site) lyase), alkylbase DNA glycosidases (Alka-family) and other DNA glycosidases; Region: ENDO3c; cd00056 443906006247 minor groove reading motif; other site 443906006248 helix-hairpin-helix signature motif; other site 443906006249 substrate binding pocket [chemical binding]; other site 443906006250 active site 443906006251 Ku protein, prokaryotic; Region: Ku_bact; TIGR02772 443906006252 Ku-core domain, Ku-like subfamily; composed of prokaryotic homologs of the eukaryotic DNA binding protein Ku. The alignment includes the core domain shared by the prokaryotic YkoV-like proteins and the eukaryotic Ku70 and Ku80. The prokaryotic Ku...; Region: KU_like; cd00789 443906006253 putative DNA binding site [nucleotide binding]; other site 443906006254 putative homodimer interface [polypeptide binding]; other site 443906006255 ATP-dependent DNA ligase; Reviewed; Region: PRK09632 443906006256 MtLigD_Pol_like: Polymerase (Pol) domain of bacterial LigD proteins similar to Mycobacterium tuberculosis (Mt)LigD. The LigD Pol domain belongs to the archaeal/eukaryal primase (AEP) superfamily. In prokaryotes, LigD along with Ku is required for...; Region: MtLigD_Pol_like; cd04863 443906006257 nucleotide binding site [chemical binding]; other site 443906006258 DNA polymerase Ligase (LigD); Region: LigD_N; cl11819 443906006259 Adenylation domain of Mycobacterium tuberculosis LigD and LigC-like ATP-dependent DNA ligases; Region: Adenylation_DNA_ligase_LigD_LigC; cd07906 443906006260 active site 443906006261 DNA binding site [nucleotide binding] 443906006262 The Oligonucleotide/oligosaccharide binding (OB)-fold domain of ATP-dependent DNA ligase LigD is a DNA-binding module that is part of the catalytic core unit; Region: OBF_DNA_ligase_LigD; cd07971 443906006263 DNA binding site [nucleotide binding] 443906006264 2-keto-4-pentenoate hydratase/2-oxohepta-3-ene-1,7-dioic acid hydratase (catechol pathway) [Secondary metabolites biosynthesis, transport, and catabolism]; Region: MhpD; COG0179 443906006265 Fumarylacetoacetate (FAA) hydrolase family; Region: FAA_hydrolase; pfam01557 443906006266 Apolipoprotein A1/A4/E domain; Region: Apolipoprotein; pfam01442 443906006267 aspartate ammonia-lyase; Provisional; Region: aspA; PRK12273 443906006268 Aspartase; Region: Aspartase; cd01357 443906006269 active sites [active] 443906006270 tetramer interface [polypeptide binding]; other site 443906006271 Predicted nuclease (RNAse H fold) [General function prediction only]; Region: COG4328 443906006272 DPM1_like represents putative enzymes similar to eukaryotic DPM1; Region: DPM1_like; cd06442 443906006273 Ligand binding site; other site 443906006274 Putative Catalytic site; other site 443906006275 DXD motif; other site 443906006276 Predicted membrane protein [Function unknown]; Region: COG2246 443906006277 GtrA-like protein; Region: GtrA; pfam04138 443906006278 Mn2+ and Fe2+ transporters of the NRAMP family [Inorganic ion transport and metabolism]; Region: MntH; COG1914 443906006279 Natural resistance-associated macrophage protein; Region: Nramp; pfam01566 443906006280 Xanthine/uracil/vitamin C permease [Nucleotide transport and metabolism]; Region: COG2252 443906006281 Phosphate/sulphate permeases [Inorganic ion transport and metabolism]; Region: PitA; COG0306 443906006282 Esterases and lipases (includes fungal lipases, cholinesterases, etc.) These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cd00312 443906006283 Carboxylesterase type B [Lipid metabolism]; Region: PnbA; COG2272 443906006284 substrate binding pocket [chemical binding]; other site 443906006285 catalytic triad [active] 443906006286 CYTH-like (also known as triphosphate tunnel metalloenzyme (TTM)-like) Phosphatases; Region: CYTH-like_Pase; cd07374 443906006287 putative active site; other site 443906006288 putative metal binding residues [ion binding]; other site 443906006289 signature motif; other site 443906006290 putative triphosphate binding site [ion binding]; other site 443906006291 CHAD domain; Region: CHAD; pfam05235 443906006292 The CHAD domain is an alpha-helical domain functionally associated with some members of the adenylate cyclase family; Region: CHAD; smart00880 443906006293 Virulence factor BrkB; Region: Virul_fac_BrkB; pfam03631 443906006294 Putative NADP-dependent oxidoreductases [General function prediction only]; Region: COG2130 443906006295 Prostaglandin dehydrogenases; Region: PGDH; cd05288 443906006296 NAD(P) binding site [chemical binding]; other site 443906006297 substrate binding site [chemical binding]; other site 443906006298 dimer interface [polypeptide binding]; other site 443906006299 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 443906006300 NmrA-like family; Region: NmrA; pfam05368 443906006301 NAD(P) binding site [chemical binding]; other site 443906006302 active site 443906006303 short chain dehydrogenase; Provisional; Region: PRK08219 443906006304 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 443906006305 NAD(P) binding site [chemical binding]; other site 443906006306 active site 443906006307 Molecular chaperone (small heat shock protein) [Posttranslational modification, protein turnover, chaperones]; Region: IbpA; COG0071 443906006308 Alpha-crystallin domain (ACD) of alpha-crystallin-type small(s) heat shock proteins (Hsps). sHsps are small stress induced proteins with monomeric masses between 12 -43 kDa, whose common feature is the Alpha-crystallin domain (ACD). sHsps are generally...; Region: ACD_sHsps-like; cd06464 443906006309 putative dimer interface [polypeptide binding]; other site 443906006310 Acetyltransferase (GNAT) domain; Region: Acetyltransf_8; pfam13523 443906006311 Siderophore biosynthesis protein domain; Region: AlcB; smart01006 443906006312 Siderophore synthetase component [Secondary metabolites biosynthesis, transport, and catabolism]; Region: RhbC; COG4264 443906006313 IucA / IucC family; Region: IucA_IucC; pfam04183 443906006314 Ferric iron reductase FhuF-like transporter; Region: FhuF; pfam06276 443906006315 Lysine/ornithine N-monooxygenase [Secondary metabolites biosynthesis, transport, and catabolism]; Region: IucD; COG3486 443906006316 Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321 443906006317 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 443906006318 catalytic residue [active] 443906006319 oxidoreductase; Provisional; Region: PRK06128 443906006320 classical (c) SDR, subgroup 1; Region: SDR_c1; cd05355 443906006321 NAD binding site [chemical binding]; other site 443906006322 metal binding site [ion binding]; metal-binding site 443906006323 active site 443906006324 Rieske domain; a [2Fe-2S] cluster binding domain commonly found in Rieske non-heme iron oxygenase (RO) systems such as naphthalene and biphenyl dioxygenases, as well as in plant/cyanobacterial chloroplast b6f and mitochondrial cytochrome bc(1) complexes; Region: Rieske; cd03467 443906006325 iron-sulfur cluster [ion binding]; other site 443906006326 [2Fe-2S] cluster binding site [ion binding]; other site 443906006327 SPFH domain / Band 7 family; Region: Band_7; pfam01145 443906006328 ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653 443906006329 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; pfam01547 443906006330 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 443906006331 dimer interface [polypeptide binding]; other site 443906006332 conserved gate region; other site 443906006333 putative PBP binding loops; other site 443906006334 ABC-ATPase subunit interface; other site 443906006335 ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395 443906006336 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 443906006337 dimer interface [polypeptide binding]; other site 443906006338 conserved gate region; other site 443906006339 putative PBP binding loops; other site 443906006340 ABC-ATPase subunit interface; other site 443906006341 Glycosyl hydrolases family 2, sugar binding domain; Region: Glyco_hydro_2_N; pfam02837 443906006342 cryptic beta-D-galactosidase subunit alpha; Reviewed; Region: ebgA; PRK10340 443906006343 Glycosyl hydrolases family 2, TIM barrel domain; Region: Glyco_hydro_2_C; pfam02836 443906006344 Beta galactosidase small chain; Region: Bgal_small_N; smart01038 443906006345 FAD-linked oxidoreductase; Region: bact_FAD_ox; TIGR01679 443906006346 FAD binding domain; Region: FAD_binding_4; pfam01565 443906006347 D-arabinono-1,4-lactone oxidase; Region: ALO; pfam04030 443906006348 NrdH-redoxin (NrdH) family; NrdH is a small monomeric protein with a conserved redox active CXXC motif within a TRX fold, characterized by a glutaredoxin (GRX)-like sequence and TRX-like activity profile. In vitro, it displays protein disulfide reductase...; Region: NrdH; cd02976 443906006349 catalytic residues [active] 443906006350 Uncharacterized protein, probably involved in trehalose biosynthesis [Carbohydrate transport and metabolism]; Region: Ble; COG3281 443906006351 Protease II [Amino acid transport and metabolism]; Region: PtrB; COG1770 443906006352 Prolyl oligopeptidase family; Region: Peptidase_S9; pfam00326 443906006353 4-methyl-5-beta-hydroxyethylthiazole (Thz) kinase catalyzes the phosphorylation of the hydroxylgroup of Thz. A reaction that allows cells to recycle Thz into the thiamine biosynthesis pathway, as an alternative to its synthesis from cysteine, tyrosine...; Region: THZ_kinase; cd01170 443906006354 substrate binding site [chemical binding]; other site 443906006355 multimerization interface [polypeptide binding]; other site 443906006356 ATP binding site [chemical binding]; other site 443906006357 Thiamine monophosphate synthase (TMP synthase)/TenI. TMP synthase catalyzes an important step in the thiamine biosynthesis pathway, the substitution of the pyrophosphate of 2-methyl-4-amino-5- hydroxymethylpyrimidine pyrophosphate by 4-methyl-5-; Region: TMP_TenI; cd00564 443906006358 pyrophosphate binding site [ion binding]; other site 443906006359 multifunctional hydroxymethylpyrimidine phosphokinase/4-amino-5-aminomethyl-2-methylpyrimidine hydrolase; Provisional; Region: PRK14713 443906006360 4-amino-5-hydroxymethyl-2-methyl-pyrimidine phosphate kinase (HMPP-kinase) catalyzes two consecutive phosphorylation steps in the thiamine phosphate biosynthesis pathway, leading to the synthesis of vitamin B1. The first step is the phosphorylation of...; Region: HMPP_kinase; cd01169 443906006361 dimer interface [polypeptide binding]; other site 443906006362 substrate binding site [chemical binding]; other site 443906006363 ATP binding site [chemical binding]; other site 443906006364 TENA/THI-4/PQQC family; Region: TENA_THI-4; cl15243 443906006365 Cupin domain; Region: Cupin_2; cl17218 443906006366 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 443906006367 putative substrate translocation pore; other site 443906006368 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 443906006369 DEAD-like helicases superfamily; Region: DEXDc; smart00487 443906006370 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 443906006371 ATP binding site [chemical binding]; other site 443906006372 putative Mg++ binding site [ion binding]; other site 443906006373 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 443906006374 nucleotide binding region [chemical binding]; other site 443906006375 ATP-binding site [chemical binding]; other site 443906006376 Predicted glutathione S-transferase [Posttranslational modification, protein turnover, chaperones]; Region: ECM4; COG0435 443906006377 Protein Disulfide Oxidoreductases and Other Proteins with a Thioredoxin fold; Region: Thioredoxin_like; cl00388 443906006378 C-terminal, alpha helical domain of Class Omega-like Glutathione S-transferases; Region: GST_C_Omega_like; cd03190 443906006379 putative dimer interface [polypeptide binding]; other site 443906006380 N-terminal domain interface [polypeptide binding]; other site 443906006381 putative substrate binding pocket (H-site) [chemical binding]; other site 443906006382 alpha/beta hydrolase fold; Region: Abhydrolase_3; pfam07859 443906006383 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 443906006384 Tetratrico peptide repeat; Region: TPR_5; pfam12688 443906006385 binding surface 443906006386 TPR motif; other site 443906006387 Alcohol dehydrogenases of the MDR family; Region: Zn_ADH6; cd08260 443906006388 Zn-dependent alcohol dehydrogenases [General function prediction only]; Region: AdhP; COG1064 443906006389 putative NAD(P) binding site [chemical binding]; other site 443906006390 catalytic Zn binding site [ion binding]; other site 443906006391 structural Zn binding site [ion binding]; other site 443906006392 Uncharacterized conserved protein [Function unknown]; Region: COG1359 443906006393 pyruvate dehydrogenase; Provisional; Region: PRK06546 443906006394 Pyrimidine (PYR) binding domain of POX; Region: TPP_PYR_POX; cd07039 443906006395 PYR/PP interface [polypeptide binding]; other site 443906006396 tetramer interface [polypeptide binding]; other site 443906006397 dimer interface [polypeptide binding]; other site 443906006398 TPP binding site [chemical binding]; other site 443906006399 Thiamine pyrophosphate enzyme, central domain; Region: TPP_enzyme_M; pfam00205 443906006400 Thiamine pyrophosphate (TPP) family, Pyruvate oxidase (POX) subfamily, TPP-binding module; composed of proteins similar to Lactobacillus plantarum POX, which plays a key role in controlling acetate production under aerobic conditions. POX decarboxylates...; Region: TPP_POX; cd02014 443906006401 TPP-binding site [chemical binding]; other site 443906006402 Protein of unknown function (DUF1684); Region: DUF1684; pfam07920 443906006403 alcohol dehydrogenase and quinone reductase-like medium chain degydrogenases/reductases; Region: MDR_like_2; cd05289 443906006404 NADPH:quinone reductase and related Zn-dependent oxidoreductases [Energy production and conversion / General function prediction only]; Region: Qor; COG0604 443906006405 putative NAD(P) binding site [chemical binding]; other site 443906006406 Transcriptional regulator [Transcription]; Region: LysR; COG0583 443906006407 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 443906006408 The C-terminal substrate binding domain of an uncharacterized LysR-type transcriptional regulator similar to DntR, which is involved in the catabolism of dinitrotoluene; contains the type 2 periplasmic binding fold; Region: PBP2_DntR_like_1; cd08460 443906006409 putative substrate binding pocket [chemical binding]; other site 443906006410 putative dimerization interface [polypeptide binding]; other site 443906006411 putative dipeptidyl peptidase, COG1506: Dipeptidyl aminopeptidases/acylaminoacyl-peptidases; Hypothetical protein 443906006412 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 443906006413 tetracycline repressor protein TetR; Provisional; Region: PRK13756 443906006414 SGNH_hydrolase, or GDSL_hydrolase, is a diverse family of lipases and esterases. The tertiary fold of the enzyme is substantially different from that of the alpha/beta hydrolase family and unique among all known hydrolases; its active site closely...; Region: SGNH_hydrolase; cl01053 443906006415 active site 443906006416 oxyanion hole [active] 443906006417 catalytic triad [active] 443906006418 atypical (a) SDRs, subgroup 2; Region: SDR_a2; cd05245 443906006419 Predicted nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: COG0702 443906006420 putative NAD(P) binding site [chemical binding]; other site 443906006421 putative active site [active] 443906006422 Protein of unknown function (DUF2867); Region: DUF2867; pfam11066 443906006423 Putative hydrophobic ligand-binding SRPBCC domain of Micromonospora echinospora CalC, human Aha1, and related proteins; Region: SRPBCC_CalC_Aha1-like; cd07814 443906006424 putative hydrophobic ligand binding site [chemical binding]; other site 443906006425 Transcriptional regulator/sugar kinase [Transcription / Carbohydrate transport and metabolism]; Region: NagC; COG1940 443906006426 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cl17037 443906006427 nucleotide binding site [chemical binding]; other site 443906006428 Polymerase and Histidinol Phosphatase domain of Histidinol phosphate phosphatase; Region: PHP_HisPPase; cd07432 443906006429 DNA polymerase alpha chain like domain; Region: POLIIIAc; smart00481 443906006430 active site 443906006431 Cyanate permease [Inorganic ion transport and metabolism]; Region: CynX; COG2807 443906006432 uncharacterized Actinobacterial protein TIGR03083; Region: TIGR03083 443906006433 Mycothiol maleylpyruvate isomerase N-terminal domain; Region: MDMPI_N; pfam11716 443906006434 bifunctional riboflavin kinase/FMN adenylyltransferase; Reviewed; Region: PRK05627 443906006435 FAD synthetase, N-terminal domain of the bifunctional enzyme; Region: FAD_synthetase_N; cd02064 443906006436 active site 443906006437 Riboflavin kinase; Region: Flavokinase; smart00904 443906006438 tRNA pseudouridine synthase B; Provisional; Region: truB; PRK03287 443906006439 Pseudouridine synthase, Escherichia coli TruB like; Region: PseudoU_synth_EcTruB; cd02573 443906006440 RNA binding site [nucleotide binding]; other site 443906006441 active site 443906006442 tRNA Pseudouridine synthase II, C terminal; Region: TruB_C; pfam09142 443906006443 2-dehydropantoate 2-reductase; Region: apbA_panE; TIGR00745 443906006444 Ketopantoate reductase PanE/ApbA; Region: ApbA; pfam02558 443906006445 Ketopantoate reductase PanE/ApbA C terminal; Region: ApbA_C; pfam08546 443906006446 Nucleoside/nucleotide kinase (NK) is a protein superfamily consisting of multiple families of enzymes that share structural similarity and are functionally related to the catalysis of the reversible phosphate group transfer from nucleoside triphosphates...; Region: NK; cl17190 443906006447 endonuclease III; includes endonuclease III (DNA-(apurinic or apyrimidinic site) lyase), alkylbase DNA glycosidases (Alka-family) and other DNA glycosidases; Region: ENDO3c; cd00056 443906006448 endonuclease III; Region: ENDO3c; smart00478 443906006449 minor groove reading motif; other site 443906006450 helix-hairpin-helix signature motif; other site 443906006451 substrate binding pocket [chemical binding]; other site 443906006452 active site 443906006453 Iron-sulfur binding domain of endonuclease III; Region: EndIII_4Fe-2S; pfam10576 443906006454 ribosome-binding factor A; Validated; Region: rbfA; PRK00521 443906006455 Translation initiation factor IF-2, N-terminal region; Region: IF2_N; pfam04760 443906006456 translation initiation factor IF-2; Region: IF-2; TIGR00487 443906006457 Translation initiation factor IF-2, N-terminal region; Region: IF2_N; pfam04760 443906006458 Initiation Factor 2 (IF2)/ eukaryotic Initiation Factor 5B (eIF5B) family; Region: IF2_eIF5B; cd01887 443906006459 G1 box; other site 443906006460 putative GEF interaction site [polypeptide binding]; other site 443906006461 GTP/Mg2+ binding site [chemical binding]; other site 443906006462 Switch I region; other site 443906006463 G2 box; other site 443906006464 G3 box; other site 443906006465 Switch II region; other site 443906006466 G4 box; other site 443906006467 G5 box; other site 443906006468 This family represents the domain II of bacterial Initiation Factor 2 (IF2) and its eukaryotic mitochondrial homologue mtIF2. IF2, the largest initiation factor is an essential GTP binding protein. In E. coli three natural forms of IF2 exist in the cell; Region: IF2_mtIF2_II; cd03702 443906006469 Translation-initiation factor 2; Region: IF-2; pfam11987 443906006470 mtIF2_IVc: this family represents the C2 subdomain of domain IV of mitochondrial translation initiation factor 2 (mtIF2) which adopts a beta-barrel fold displaying a high degree of structural similarity with domain II of the translation elongation factor...; Region: mtIF2_IVc; cd03692 443906006471 Protein of unknown function (DUF448); Region: DUF448; pfam04296 443906006472 putative RNA binding cleft [nucleotide binding]; other site 443906006473 transcription elongation factor NusA; Provisional; Region: nusA; PRK12327 443906006474 NusA N-terminal domain; Region: NusA_N; pfam08529 443906006475 S1_NusA: N-utilizing substance A protein (NusA), S1-like RNA-binding domain. S1-like RNA-binding domains are found in a wide variety of RNA-associated proteins. NusA is a transcription elongation factor containing an N-terminal catalytic domain and three...; Region: S1_NusA; cd04455 443906006476 RNA binding site [nucleotide binding]; other site 443906006477 homodimer interface [polypeptide binding]; other site 443906006478 NusA-like KH domain; Region: KH_5; pfam13184 443906006479 NusA_K homology RNA-binding domain (KH). NusA is an essential multifunctional transcription elongation factor that is universally conserved among prokaryotes and archaea. NusA anti-termination function plays an important role in the expression of...; Region: NusA_KH; cd02134 443906006480 G-X-X-G motif; other site 443906006481 prolyl-tRNA synthetase; Provisional; Region: PRK09194 443906006482 Prolyl-tRNA synthetase (ProRS) class II core catalytic domain. ProRS is a homodimer. It is responsible for the attachment of proline to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for ATP-dependent...; Region: ProRS_core_prok; cd00779 443906006483 dimer interface [polypeptide binding]; other site 443906006484 motif 1; other site 443906006485 active site 443906006486 motif 2; other site 443906006487 INS is an amino acid-editing domain inserted (INS) into the bacterial class II prolyl-tRNA synthetase (ProRS) however, this CD is not exclusively bacterial. It is also found at the N-terminus of the eukaryotic/archaea-like ProRS's of yeasts and...; Region: ProRS-INS; cd04334 443906006488 putative deacylase active site [active] 443906006489 Class II tRNA amino-acyl synthetase-like catalytic core domain. Class II amino acyl-tRNA synthetases (aaRS) share a common fold and generally attach an amino acid to the 3' OH of ribose of the appropriate tRNA. PheRS is an exception in that it...; Region: class_II_aaRS-like_core; cl00268 443906006490 active site 443906006491 motif 3; other site 443906006492 ProRS Prolyl-anticodon binding domain, short version found predominantly in bacteria. ProRS belongs to class II aminoacyl-tRNA synthetases (aaRS). This alignment contains the anticodon binding domain, which is responsible for specificity in tRNA-binding; Region: ProRS_anticodon_short; cd00861 443906006493 anticodon binding site; other site 443906006494 Nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: WcaG; COG0451 443906006495 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 443906006496 NAD(P) binding site [chemical binding]; other site 443906006497 active site 443906006498 Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596 443906006499 peptide synthase; Provisional; Region: PRK09274 443906006500 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 443906006501 acyl-activating enzyme (AAE) consensus motif; other site 443906006502 AMP binding site [chemical binding]; other site 443906006503 active site 443906006504 CoA binding site [chemical binding]; other site 443906006505 3-oxoacyl-(acyl carrier protein) synthase III; Reviewed; Region: PRK09258 443906006506 Condensing enzymes; Family of enzymes that catalyze a (decarboxylating or non-decarboxylating) Claisen-like condensation reaction. Members are share strong structural similarity, and are involved in the synthesis and degradation of fatty acids, and the...; Region: cond_enzymes; cl09938 443906006507 active site 443906006508 4-hydroxy-3-methylbut-2-en-1-yl diphosphate synthase; Reviewed; Region: ispG; PRK00366 443906006509 4-hydroxy-3-methylbut-2-en-1-yl diphosphate synthase; Validated; Region: PRK00694 443906006510 4-hydroxy-3-methylbut-2-en-1-yl diphosphate synthase; Validated; Region: PRK00694 443906006511 RseP-like Site-2 proteases (S2P), zinc metalloproteases (MEROPS family M50A), cleave transmembrane domains of substrate proteins, regulating intramembrane proteolysis (RIP) of diverse signal transduction mechanisms. In Escherichia coli, the S2P homolog...; Region: S2P-M50_PDZ_RseP-like; cd06163 443906006512 active site 443906006513 Predicted membrane-associated Zn-dependent proteases 1 [Cell envelope biogenesis, outer membrane]; Region: COG0750 443906006514 PDZ domain of bacterial and plant zinc metalloprotases, presumably membrane-associated or integral membrane proteases, which may be involved in signalling and regulatory mechanisms. May be responsible for substrate recognition and/or binding, as most PDZ...; Region: PDZ_metalloprotease; cd00989 443906006515 Site-2 protease (S2P) class of zinc metalloproteases (MEROPS family M50) cleaves transmembrane domains of substrate proteins, regulating intramembrane proteolysis (RIP) of diverse signal transduction mechanisms. Members of this family use proteolytic...; Region: S2P-M50; cl10020 443906006516 putative substrate binding region [chemical binding]; other site 443906006517 Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220 443906006518 Catalytic domain of Protein Kinases; Region: PKc; cd00180 443906006519 active site 443906006520 ATP binding site [chemical binding]; other site 443906006521 substrate binding site [chemical binding]; other site 443906006522 activation loop (A-loop); other site 443906006523 type VI secretion ATPase, ClpV1 family; Region: VI_ClpV1; TIGR03345 443906006524 1-deoxy-D-xylulose 5-phosphate reductoisomerase; Provisional; Region: PRK05447 443906006525 1-deoxy-D-xylulose 5-phosphate reductoisomerase; Region: DXP_reductoisom; pfam02670 443906006526 1-deoxy-D-xylulose 5-phosphate reductoisomerase C-terminal; Region: DXP_redisom_C; pfam08436 443906006527 DXP reductoisomerase C-terminal domain; Region: DXPR_C; pfam13288 443906006528 FKBP-type peptidyl-prolyl cis-trans isomerase; Region: FKBP_C; pfam00254 443906006529 OsmC-like protein; Region: OsmC; cl00767 443906006530 4-aminobutyrate aminotransferase; Provisional; Region: PRK06058 443906006531 Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610 443906006532 inhibitor-cofactor binding pocket; inhibition site 443906006533 pyridoxal 5'-phosphate binding site [chemical binding]; other site 443906006534 catalytic residue [active] 443906006535 L-asparaginase II; Region: Asparaginase_II; pfam06089 443906006536 FtsK/SpoIIIE family; Region: FtsK_SpoIIIE; pfam01580 443906006537 FtsK/SpoIIIE family; Region: FtsK_SpoIIIE; pfam01580 443906006538 Transglutaminase-like superfamily; Region: Transglut_core; pfam01841 443906006539 Protein of unknown function DUF58; Region: DUF58; pfam01882 443906006540 MoxR-like ATPases [General function prediction only]; Region: COG0714 443906006541 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 443906006542 Walker A motif; other site 443906006543 ATP binding site [chemical binding]; other site 443906006544 Walker B motif; other site 443906006545 arginine finger; other site 443906006546 Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all...; Region: FN3; cd00063 443906006547 Interdomain contacts; other site 443906006548 Cytokine receptor motif; other site 443906006549 Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220 443906006550 Catalytic domain of Protein Kinases; Region: PKc; cd00180 443906006551 active site 443906006552 ATP binding site [chemical binding]; other site 443906006553 substrate binding site [chemical binding]; other site 443906006554 activation loop (A-loop); other site 443906006555 Escherichia coli (Ec) citrate synthase (CS) GltA_like. CS catalyzes the condensation of acetyl coenzyme A (AcCoA) and oxalacetate (OAA) to form citrate and coenzyme A (CoA), the first step in the citric acid cycle (TCA or Krebs cycle). The overall CS...; Region: EcCS_like; cd06114 443906006556 dimer interface [polypeptide binding]; other site 443906006557 Citrate synthase; Region: Citrate_synt; pfam00285 443906006558 active site 443906006559 citrylCoA binding site [chemical binding]; other site 443906006560 NADH binding [chemical binding]; other site 443906006561 cationic pore residues; other site 443906006562 oxalacetate/citrate binding site [chemical binding]; other site 443906006563 coenzyme A binding site [chemical binding]; other site 443906006564 catalytic triad [active] 443906006565 N-succinyldiaminopimelate aminotransferase; Reviewed; Region: PRK07865 443906006566 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 443906006567 pyridoxal 5'-phosphate binding site [chemical binding]; other site 443906006568 homodimer interface [polypeptide binding]; other site 443906006569 catalytic residue [active] 443906006570 Ferredoxin [Energy production and conversion]; Region: COG1146 443906006571 4Fe-4S binding domain; Region: Fer4; pfam00037 443906006572 GlcNAc-PI de-N-acetylase; Region: PIG-L; cl00929 443906006573 Iron permease FTR1 family; Region: FTR1; pfam03239 443906006574 Predicted periplasmic lipoprotein involved in iron transport [Inorganic ion transport and metabolism]; Region: COG2822 443906006575 Imelysin; Region: Peptidase_M75; pfam09375 443906006576 Dyp-type peroxidase family; Region: Dyp_perox; cl01067 443906006577 Tyrosine phosphorylated protein A (TypA)/BipA family belongs to ribosome-binding GTPases; Region: TypA_BipA; cd01891 443906006578 GTP-binding protein TypA/BipA; Region: TypA_BipA; TIGR01394 443906006579 G1 box; other site 443906006580 putative GEF interaction site [polypeptide binding]; other site 443906006581 GTP/Mg2+ binding site [chemical binding]; other site 443906006582 Switch I region; other site 443906006583 G2 box; other site 443906006584 G3 box; other site 443906006585 Switch II region; other site 443906006586 G4 box; other site 443906006587 G5 box; other site 443906006588 BipA_TypA_II: domain II of BipA (also called TypA) having homology to domain II of the elongation factors (EFs) EF-G and EF-Tu. BipA is a highly conserved protein with global regulatory properties in Escherichia coli. BipA is phosphorylated on a...; Region: BipA_TypA_II; cd03691 443906006589 BipA_TypA_C: a C-terminal portion of BipA or TypA having homology to the C terminal domains of the elongation factors EF-G and EF-2. A member of the ribosome binding GTPase superfamily, BipA is widely distributed in bacteria and plants. BipA is a highly...; Region: BipA_TypA_C; cd03710 443906006590 The substrate-binding domain of mycobacterial lipoprotein Lpqw contains type 2 periplasmic binding fold; Region: PBP2_Lpqw; cd08501 443906006591 Bacterial extracellular solute-binding proteins, family 5 Middle; Region: SBP_bac_5; pfam00496 443906006592 ATPase components of various ABC-type transport systems, contain duplicated ATPase [General function prediction only]; Region: COG1123 443906006593 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 443906006594 Walker A/P-loop; other site 443906006595 ATP binding site [chemical binding]; other site 443906006596 Q-loop/lid; other site 443906006597 ABC transporter signature motif; other site 443906006598 Walker B; other site 443906006599 D-loop; other site 443906006600 H-loop/switch region; other site 443906006601 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097 443906006602 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 443906006603 Walker A/P-loop; other site 443906006604 ATP binding site [chemical binding]; other site 443906006605 Q-loop/lid; other site 443906006606 ABC transporter signature motif; other site 443906006607 Walker B; other site 443906006608 D-loop; other site 443906006609 H-loop/switch region; other site 443906006610 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; pfam08352 443906006611 Protein of unknown function (DUF2581); Region: DUF2581; pfam10756 443906006612 oligopeptide ABC transporter permease OppC; Provisional; Region: PRK15406 443906006613 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 443906006614 ABC-ATPase subunit interface; other site 443906006615 putative PBP binding loops; other site 443906006616 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppB; COG0601 443906006617 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cl00427 443906006618 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 443906006619 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppB; COG0601 443906006620 putative PBP binding loops; other site 443906006621 dimer interface [polypeptide binding]; other site 443906006622 ABC-ATPase subunit interface; other site 443906006623 ABC-type oligopeptide transport system, periplasmic component [Amino acid transport and metabolism]; Region: OppA; COG4166 443906006624 The substrate-binding domain of mycobacterial lipoprotein Lpqw contains type 2 periplasmic binding fold; Region: PBP2_Lpqw; cd08501 443906006625 CAAX protease self-immunity; Region: Abi; pfam02517 443906006626 Protein of unknown function, DUF485; Region: DUF485; pfam04341 443906006627 Predicted symporter [General function prediction only]; Region: DhlC; COG4147 443906006628 Uncharacterized bacterial solute carrier 5 subfamily; putative solute-binding domain; Region: SLC5sbd_u4; cd11480 443906006629 Na binding site [ion binding]; other site 443906006630 Helix-turn-helix domain, rpiR family; Region: HTH_6; pfam01418 443906006631 Transcriptional regulators [Transcription]; Region: RpiR; COG1737 443906006632 RpiR-like protein. RpiR contains a SIS (Sugar ISomerase) domain, which is found in many phosphosugar isomerases and phosphosugar binding proteins. In E. coli, rpiR negatively regulates the expression of rpiB gene. Both rpiB and rpiA are ribose phosphate...; Region: SIS_RpiR; cd05013 443906006633 putative active site [active] 443906006634 phosphonate ABC transporter, permease protein PhnE; Region: PhnE; TIGR01097 443906006635 phosphonate ABC transporter, permease protein PhnE; Region: PhnE; TIGR01097 443906006636 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 443906006637 dimer interface [polypeptide binding]; other site 443906006638 conserved gate region; other site 443906006639 ABC-ATPase subunit interface; other site 443906006640 ABC-type phosphate/phosphonate transport system, ATPase component [Inorganic ion transport and metabolism]; Region: COG3638 443906006641 ATP-binding cassette domain of the binding protein-dependent phosphonate transport system; Region: ABC_PhnC_transporter; cd03256 443906006642 Walker A/P-loop; other site 443906006643 ATP binding site [chemical binding]; other site 443906006644 Q-loop/lid; other site 443906006645 ABC transporter signature motif; other site 443906006646 Walker B; other site 443906006647 D-loop; other site 443906006648 H-loop/switch region; other site 443906006649 ABC transporter, phosphonate, periplasmic substrate-binding protein; Region: Phosphonate-bd; pfam12974 443906006650 Predicted hydrolase (HAD superfamily) [General function prediction only]; Region: COG1011 443906006651 glycine dehydrogenase; Provisional; Region: PRK05367 443906006652 Glycine cleavage system P-protein, alpha- and beta-subunits. This family consists of Glycine cleavage system P-proteins EC:1.4.4.2 from bacterial, mammalian and plant sources. The P protein is part of the glycine decarboxylase multienzyme complex EC:2.1; Region: GDC-P; cd00613 443906006653 tetramer interface [polypeptide binding]; other site 443906006654 pyridoxal 5'-phosphate binding site [chemical binding]; other site 443906006655 catalytic residue [active] 443906006656 Glycine cleavage system P-protein, alpha- and beta-subunits. This family consists of Glycine cleavage system P-proteins EC:1.4.4.2 from bacterial, mammalian and plant sources. The P protein is part of the glycine decarboxylase multienzyme complex EC:2.1; Region: GDC-P; cd00613 443906006657 tetramer interface [polypeptide binding]; other site 443906006658 pyridoxal 5'-phosphate binding site [chemical binding]; other site 443906006659 catalytic residue [active] 443906006660 Glycine cleavage H-protein. Glycine cleavage H-proteins are part of the glycine cleavage system (GCS) found in bacteria, archea and the mitochondria of eukaryotes. GCS is a multienzyme complex consisting of 4 different components (P-, H-, T- and...; Region: GCS_H; cd06848 443906006661 lipoyl attachment site [posttranslational modification]; other site 443906006662 glycine cleavage system aminomethyltransferase T; Reviewed; Region: gcvT; PRK00389 443906006663 Glycine cleavage T-protein C-terminal barrel domain; Region: GCV_T_C; pfam08669 443906006664 Penicillinase repressor; Region: Pencillinase_R; cl17580 443906006665 CopC domain; Region: CopC; pfam04234 443906006666 Selenocysteine lyase/Cysteine desulfurase [Posttranslational modification, protein turnover, chaperones]; Region: csdA; COG0520 443906006667 Cysteine desulfurase (SufS)-like. This family belongs to the pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to cysteine desulfurase (SufS) and selenocysteine lyase. SufS...; Region: SufS_like; cd06453 443906006668 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 443906006669 catalytic residue [active] 443906006670 NifU homolog involved in Fe-S cluster formation [Energy production and conversion]; Region: IscU; COG0822 443906006671 Iron-sulfur cluster scaffold-like proteins; Region: IscU_like; cd06664 443906006672 trimerization site [polypeptide binding]; other site 443906006673 active site 443906006674 ChaB; Region: ChaB; cl01887 443906006675 Rho termination factor, N-terminal domain; Region: Rho_N; cl06505 443906006676 Glycosyl hydrolase family 43; Region: GH43_6; cd08985 443906006677 active site 443906006678 Di-glucose binding within endoplasmic reticulum; Region: Malectin; pfam11721 443906006679 Acetyltransferase (GNAT) domain; Region: Acetyltransf_3; pfam13302 443906006680 Acetyltransferase (GNAT) family; Region: Acetyltransf_1; pfam00583 443906006681 T5orf172 domain; Region: T5orf172; pfam10544 443906006682 Response regulator receiver domain; Region: Response_reg; pfam00072 443906006683 Amino acid permease; Region: AA_permease_2; pfam13520 443906006684 Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293 443906006685 Ligand Binding Site [chemical binding]; other site 443906006686 TlpA-like family; composed of TlpA, ResA, DsbE and similar proteins. TlpA, ResA and DsbE are bacterial protein disulfide reductases with important roles in cytochrome maturation. They are membrane-anchored proteins with a soluble TRX domain containing a...; Region: TlpA_like_family; cd02966 443906006687 Thioredoxin-like; Region: Thioredoxin_8; pfam13905 443906006688 catalytic residues [active] 443906006689 Putative peptidoglycan binding domain; Region: PG_binding_1; pfam01471 443906006690 Gamma-aminobutyrate permease and related permeases [Amino acid transport and metabolism]; Region: AnsP; COG1113 443906006691 Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067 443906006692 catalytic core [active] 443906006693 Protein of unknown function (DUF3090); Region: DUF3090; pfam11290 443906006694 conserved hypothetical protein; Region: TIGR03843 443906006695 Domain of unknown function (DUF955); Region: DUF955; pfam06114 443906006696 GTP-binding protein YchF; Reviewed; Region: PRK09601 443906006697 YchF GTPase; Region: YchF; cd01900 443906006698 G1 box; other site 443906006699 GTP/Mg2+ binding site [chemical binding]; other site 443906006700 Switch I region; other site 443906006701 G2 box; other site 443906006702 Switch II region; other site 443906006703 G3 box; other site 443906006704 G4 box; other site 443906006705 G5 box; other site 443906006706 TGS_YchF_C: This subfamily represents TGS domain-containing YchF GTP-binding protein, a universally conserved GTPase whose function is unknown. The N-terminal domain of the YchF protein belongs to the Obg-like family of GTPases, and some members of the...; Region: TGS_YchF_C; cd04867 443906006707 an uncharacterized bacterial subgroup of the DEDDh 3'-5' exonuclease domain family with similarity to the epsilon subunit of DNA polymerase III; Region: DNA_pol_III_epsilon_like; cd06130 443906006708 active site 443906006709 catalytic site [active] 443906006710 substrate binding site [chemical binding]; other site 443906006711 RmuC family; Region: RmuC; pfam02646 443906006712 fructose-bisphosphate aldolase; Provisional; Region: PRK09197 443906006713 Fructose/tagarose-bisphosphate aldolase class II. This family includes fructose-1,6-bisphosphate (FBP) and tagarose 1,6-bisphosphate (TBP) aldolases. FBP-aldolase is homodimeric and used in gluconeogenesis and glycolysis; the enzyme controls the...; Region: FTBP_aldolase_II; cl17181 443906006714 active site 443906006715 intersubunit interface [polypeptide binding]; other site 443906006716 zinc binding site [ion binding]; other site 443906006717 Na+ binding site [ion binding]; other site 443906006718 4-Hydroxy-3-methylbut-2-enyl diphosphate reductase IspH [Lipid metabolism]; Region: lytB; COG0761 443906006719 4-hydroxy-3-methylbut-2-enyl diphosphate reductase; Reviewed; Region: ispH; PRK01045 443906006720 exodeoxyribonuclease VII large subunit; Reviewed; Region: xseA; PRK00286 443906006721 ExoVII_LU_OBF: A subfamily of OB folds corresponding to the N-terminal OB-fold domain of Escherichia coli exodeoxyribonuclease VII (ExoVII) large subunit. E. coli ExoVII is composed of two non-identical subunits. E. coli ExoVII is a...; Region: ExoVII_LU_OBF; cd04489 443906006722 generic binding surface II; other site 443906006723 generic binding surface I; other site 443906006724 exodeoxyribonuclease VII small subunit; Provisional; Region: PRK00977 443906006725 Protein of unknown function (DUF4245); Region: DUF4245; pfam14030 443906006726 Carbonic anhydrases (CA) are zinc-containing enzymes that catalyze the reversible hydration of carbon dioxide in a two-step mechanism in which the nucleophilic attack of a zinc-bound hydroxide ion on carbon dioxide is followed by the regeneration of an...; Region: beta_CA_cladeC; cd03378 443906006727 active site clefts [active] 443906006728 zinc binding site [ion binding]; other site 443906006729 dimer interface [polypeptide binding]; other site 443906006730 fumarate hydratase; Reviewed; Region: fumC; PRK00485 443906006731 Class II fumarases; Region: Fumarase_classII; cd01362 443906006732 active site 443906006733 tetramer interface [polypeptide binding]; other site 443906006734 NYN ribonuclease and ATPase of PhoH family domains [General function prediction only]; Region: COG1875 443906006735 PIN domain of bacterial Smg6-like homologs with PhoH-like ATPase domains; Region: PIN_PhoHL-ATPase; cd09883 443906006736 putative active site [active] 443906006737 PhoH-like protein; Region: PhoH; pfam02562 443906006738 Cis (Z)-Isoprenyl Diphosphate Synthases (cis-IPPS); homodimers which catalyze the successive 1'-4 condensation of the isopentenyl diphosphate (IPP) molecule to trans,trans-farnesyl diphosphate (FPP) or to cis,trans-FPP to form long-chain polyprenyl...; Region: CIS_IPPS; cl00230 443906006739 Putative undecaprenyl diphosphate synthase; Region: Prenyltransf; pfam01255 443906006740 catalytic residue [active] 443906006741 putative FPP diphosphate binding site; other site 443906006742 putative FPP binding hydrophobic cleft; other site 443906006743 dimer interface [polypeptide binding]; other site 443906006744 putative IPP diphosphate binding site; other site 443906006745 Haemolysin-III related; Region: HlyIII; pfam03006 443906006746 ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653 443906006747 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; cl17199 443906006748 ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395 443906006749 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 443906006750 dimer interface [polypeptide binding]; other site 443906006751 conserved gate region; other site 443906006752 putative PBP binding loops; other site 443906006753 ABC-ATPase subunit interface; other site 443906006754 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 443906006755 dimer interface [polypeptide binding]; other site 443906006756 conserved gate region; other site 443906006757 ABC-ATPase subunit interface; other site 443906006758 GlcNAc-PI de-N-acetylase; Region: PIG-L; cl00929 443906006759 Domain of unknown function (DUF4307); Region: DUF4307; pfam14155 443906006760 transcription elongation factor GreA; Reviewed; Region: greA; PRK00226 443906006761 Transcription elongation factor, N-terminal; Region: GreA_GreB_N; pfam03449 443906006762 Transcription elongation factor, GreA/GreB, C-term; Region: GreA_GreB; pfam01272 443906006763 threonine dehydratase; Provisional; Region: PRK08198 443906006764 Threonine dehydratase: The first step in amino acid degradation is the removal of nitrogen. Although the nitrogen atoms of most amino acids are transferred to alpha-ketoglutarate before removal, the alpha-amino group of threonine can be directly...; Region: Thr-dehyd; cd01562 443906006765 tetramer interface [polypeptide binding]; other site 443906006766 pyridoxal 5'-phosphate binding site [chemical binding]; other site 443906006767 catalytic residue [active] 443906006768 C-terminal ACT domain of biodegradative (catabolic) threonine dehydratase II (ThrD-II) and other related ACT domains; Region: ACT_ThrD-II-like; cd04886 443906006769 Predicted permease, member of the PurR regulon [General function prediction only]; Region: yhhT; COG0628 443906006770 Domain of unknown function DUF20; Region: UPF0118; pfam01594 443906006771 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3214 443906006772 Protein of unknown function (DUF1006); Region: DUF1006; pfam06224 443906006773 Uncharacterized conserved protein [Function unknown]; Region: LemA; COG1704 443906006774 Glycosyl hydrolase family 1; Region: Glyco_hydro_1; cl01046 443906006775 beta-galactosidase; Region: BGL; TIGR03356 443906006776 Bacterial Ig-like domain (group 3); Region: Big_3_4; pfam13754 443906006777 amino acid transporter; Region: 2A0306; TIGR00909 443906006778 C-terminus of AA_permease; Region: AA_permease_C; pfam13906 443906006779 Ferritin-like domain; Region: Ferritin_2; pfam13668 443906006780 Beta-mannanase [Carbohydrate transport and metabolism]; Region: ManB; COG4124 443906006781 OpgC protein; Region: OpgC_C; pfam10129 443906006782 Acyltransferase family; Region: Acyl_transf_3; pfam01757 443906006783 Domain of unknown function (DUF1850); Region: DUF1850; cl01950 443906006784 Histidine kinase-like ATPase domain; Region: HATPase_c_2; pfam13581 443906006785 Sulphate Transporter and Anti-Sigma factor antagonist) domain of anti-anti-sigma factors, key regulators of anti-sigma factors by phosphorylation; Region: STAS_anti-anti-sigma_factors; cd07043 443906006786 Sulfate permease and related transporters (MFS superfamily) [Inorganic ion transport and metabolism]; Region: SUL1; COG0659 443906006787 anti sigma factor interaction site; other site 443906006788 regulatory phosphorylation site [posttranslational modification]; other site 443906006789 CESA_CelA_like are involved in the elongation of the glucan chain of cellulose; Region: CESA_CelA_like; cd06421 443906006790 DXD motif; other site 443906006791 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394 443906006792 FOG: GAF domain [Signal transduction mechanisms]; Region: FhlA; COG2203 443906006793 GAF domain; Region: GAF; pfam01590 443906006794 Serine phosphatase RsbU, regulator of sigma subunit [Signal transduction mechanisms / Transcription]; Region: RsbU; COG2208 443906006795 Stage II sporulation protein E (SpoIIE); Region: SpoIIE; pfam07228 443906006796 Predicted acyltransferases [Lipid metabolism]; Region: COG1835 443906006797 NADH dehydrogenase, FAD-containing subunit [Energy production and conversion]; Region: Ndh; COG1252 443906006798 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 443906006799 Peptidase domain in the S8 and S53 families; Region: Peptidases_S8_S53; cl10459 443906006800 active site 443906006801 catalytic residues [active] 443906006802 Protein of unknown function (DUF501); Region: DUF501; pfam04417 443906006803 Septum formation initiator; Region: DivIC; cl17659 443906006804 enolase; Provisional; Region: eno; PRK00077 443906006805 Enolase: Enolases are homodimeric enzymes that catalyse the reversible dehydration of 2-phospho-D-glycerate to phosphoenolpyruvate as part of the glycolytic and gluconeogenesis pathways. The reaction is facilitated by the presence of metal ions; Region: enolase; cd03313 443906006806 dimer interface [polypeptide binding]; other site 443906006807 metal binding site [ion binding]; metal-binding site 443906006808 substrate binding pocket [chemical binding]; other site 443906006809 histidyl-tRNA synthetase; Region: hisS; TIGR00442 443906006810 Class II Histidinyl-tRNA synthetase (HisRS)-like catalytic core domain. HisRS is a homodimer. It is responsible for the attachment of histidine to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for...; Region: HisRS-like_core; cd00773 443906006811 dimer interface [polypeptide binding]; other site 443906006812 motif 1; other site 443906006813 active site 443906006814 motif 2; other site 443906006815 motif 3; other site 443906006816 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 443906006817 MazG family protein; Region: mazG; TIGR00444 443906006818 Nucleoside Triphosphate Pyrophosphohydrolase (EC 3.6.1.8) N-terminal tandem-domain of MazG proteins from Escherichia coli and bacterial homologs; Region: NTP-PPase_MazG_Nterm; cd11528 443906006819 homodimer interface [polypeptide binding]; other site 443906006820 metal binding site [ion binding]; metal-binding site 443906006821 Nucleoside Triphosphate Pyrophosphohydrolase (EC 3.6.1.8) MazG-like domain superfamily; Region: NTP-PPase; cl16941 443906006822 Na+/H+ antiporter 1; Region: Na_H_antiport_1; cl01133 443906006823 Transcription-repair coupling factor (superfamily II helicase) [DNA replication, recombination, and repair / Transcription]; Region: Mfd; COG1197 443906006824 CarD-like/TRCF domain; Region: CarD_TRCF; smart01058 443906006825 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 443906006826 ATP binding site [chemical binding]; other site 443906006827 putative Mg++ binding site [ion binding]; other site 443906006828 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 443906006829 nucleotide binding region [chemical binding]; other site 443906006830 ATP-binding site [chemical binding]; other site 443906006831 This domain is found in proteins necessary for strand-specific repair in DNA such as TRCF in Escherichia coli; Region: TRCF; smart00982 443906006832 Peptidyl-tRNA hydrolase (PTH) is a monomeric protein that cleaves the ester bond linking the nascent peptide and tRNA when peptidyl-tRNA is released prematurely from the ribosome. This ensures the recycling of peptidyl-tRNAs into tRNAs produced through...; Region: PTH; cd00462 443906006833 putative active site [active] 443906006834 catalytic residue [active] 443906006835 50S ribosomal protein L25/general stress protein Ctc; Reviewed; Region: PRK05618 443906006836 Ribosomal L25/TL5/CTC N-terminal 5S rRNA binding domain; Region: Ribosomal_L25_TL5_CTC; cd00495 443906006837 5S rRNA interface [nucleotide binding]; other site 443906006838 CTC domain interface [polypeptide binding]; other site 443906006839 L16 interface [polypeptide binding]; other site 443906006840 Gluconate kinase (GntK) catalyzes the phosphoryl transfer from ATP to gluconate. The resulting product gluconate-6-phoshate is an important precursor of gluconate metabolism. GntK acts as a dimmer composed of two identical subunits; Region: GntK; cd02021 443906006841 AAA domain; Region: AAA_33; pfam13671 443906006842 ATP-binding site [chemical binding]; other site 443906006843 Gluconate-6-phosphate binding site [chemical binding]; other site 443906006844 Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673 443906006845 Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408 443906006846 Oxidoreductase family, C-terminal alpha/beta domain; Region: GFO_IDH_MocA_C; pfam02894 443906006847 6-phosphogluconate dehydrogenase-like protein; Reviewed; Region: PRK09599 443906006848 6-phosphogluconate dehydrogenase; Validated; Region: PRK09287 443906006849 6-phosphogluconate dehydrogenase, C-terminal domain; Region: 6PGD; pfam00393 443906006850 N-terminal domain of ribose phosphate pyrophosphokinase; Region: Pribosyltran_N; pfam13793 443906006851 ribose-phosphate pyrophosphokinase; Provisional; Region: PRK03092 443906006852 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 443906006853 active site 443906006854 bifunctional N-acetylglucosamine-1-phosphate uridyltransferase/glucosamine-1-phosphate acetyltransferase; Provisional; Region: glmU; PRK14352 443906006855 N-terminal domain of bacterial GlmU; Region: GT2_GlmU_N_bac; cd02540 443906006856 Substrate binding site; other site 443906006857 Mg++ binding site; other site 443906006858 N-acetyl-glucosamine-1-phosphate uridyltransferase (GlmU), C-terminal left-handed beta-helix (LbH) acetyltransferase domain: GlmU is also known as UDP-N-acetylglucosamine pyrophosphorylase. It is a bifunctional bacterial enzyme that catalyzes two...; Region: LbH_GlmU_C; cd03353 443906006859 active site 443906006860 substrate binding site [chemical binding]; other site 443906006861 CoA binding site [chemical binding]; other site 443906006862 MarR family; Region: MarR_2; pfam12802 443906006863 Prokaryotic dksA/traR C4-type zinc finger; Region: zf-dskA_traR; cl00755 443906006864 luciferase family oxidoreductase, group 1; Region: oxido_grp_1; TIGR03558 443906006865 Flavin-utilizing monoxygenases; Region: Flavin_utilizing_monoxygenases; cl07892 443906006866 Lysine efflux permease [General function prediction only]; Region: COG1279 443906006867 chromosome replication initiation inhibitor protein; Validated; Region: PRK03635 443906006868 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 443906006869 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 443906006870 dimerization interface [polypeptide binding]; other site 443906006871 ABC-type metal ion transport system, permease component [Inorganic ion transport and metabolism]; Region: AbcD; COG2011 443906006872 dimer interface [polypeptide binding]; other site 443906006873 conserved gate region; other site 443906006874 ABC-ATPase subunit interface; other site 443906006875 ABC-type metal ion transport system, ATPase component [Inorganic ion transport and metabolism]; Region: AbcC; COG1135 443906006876 ATP-binding cassette domain of methionine transporter; Region: ABC_MetN_methionine_transporter; cd03258 443906006877 Walker A/P-loop; other site 443906006878 ATP binding site [chemical binding]; other site 443906006879 Q-loop/lid; other site 443906006880 ABC transporter signature motif; other site 443906006881 Walker B; other site 443906006882 D-loop; other site 443906006883 H-loop/switch region; other site 443906006884 This domain is found at the C-terminus of ABC transporter proteins involved in D-methionine transport as well as a number of ferredoxin-like proteins; Region: NIL; smart00930 443906006885 NLPA lipoprotein; Region: Lipoprotein_9; cl17547 443906006886 ATPase components of ABC transporters with duplicated ATPase domains [General function prediction only]; Region: Uup; COG0488 443906006887 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 443906006888 ABC transporter; Region: ABC_tran_2; pfam12848 443906006889 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 443906006890 Site-specific recombinases, DNA invertase Pin homologs [DNA replication, recombination, and repair]; Region: PinR; COG1961 443906006891 Serine Recombinase family, catalytic domain; a DNA binding domain may be present either N- or C-terminal to the catalytic domain. These enzymes perform site-specific recombination of DNA molecules by a concerted, four-strand cleavage and rejoining...; Region: Ser_Recombinase; cd00338 443906006892 catalytic residues [active] 443906006893 catalytic nucleophile [active] 443906006894 Recombinase; Region: Recombinase; pfam07508 443906006895 Recombinase zinc beta ribbon domain; Region: Zn_ribbon_recom; pfam13408 443906006896 FtsK/SpoIIIE family; Region: FtsK_SpoIIIE; pfam01580 443906006897 Recombination endonuclease VII; Region: Endonuclease_7; pfam02945 443906006898 HNH nucleases; HNH endonuclease signature which is found in viral, prokaryotic, and eukaryotic proteins. The alignment includes members of the large group of homing endonucleases, yeast intron 1 protein, MutS, as well as bacterial colicins, pyocins, and...; Region: HNHc; cd00085 443906006899 active site 443906006900 Resolvase, N terminal domain; Region: Resolvase; smart00857 443906006901 multiple promoter invertase; Provisional; Region: mpi; PRK13413 443906006902 catalytic residues [active] 443906006903 catalytic nucleophile [active] 443906006904 N-terminal catalytic GIY-YIG domain of bacteriophage T4 segABCDEFG gene encoding proteins; Region: GIY-YIG_SegABCDEFG; cd10444 443906006905 GIY-YIG motif/motif A; other site 443906006906 putative active site [active] 443906006907 putative metal binding site [ion binding]; other site 443906006908 ParB-like nuclease domain; Region: ParBc; cl02129 443906006909 putative ABC transporter, ATP-binding subunit,COG0488: ATPase components of ABC transporters with duplicated ATPase domains; Hypothetical protein 443906006910 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 443906006911 Major Facilitator Superfamily; Region: MFS_1; pfam07690 443906006912 Predicted membrane protein (DUF2142); Region: DUF2142; pfam09913 443906006913 Predicted membrane protein [Function unknown]; Region: COG2246 443906006914 GtrA-like protein; Region: GtrA; pfam04138 443906006915 dolichyl-phosphate beta-D-mannosyltransferase; Region: PLN02726 443906006916 DPM_DPG-synthase_like is a member of the Glycosyltransferase 2 superfamily; Region: DPM_DPG-synthase_like; cd04179 443906006917 Ligand binding site; other site 443906006918 Putative Catalytic site; other site 443906006919 DXD motif; other site 443906006920 moaE-homolog; Hypothetical protein 443906006921 MoaE family. Members of this family are involved in biosynthesis of the molybdenum cofactor (Moco), an essential cofactor for a diverse group of redox enzymes. Moco biosynthesis is an evolutionarily conserved pathway present in eubacteria, archaea and...; Region: MoaE; cd00756 443906006922 MoaE homodimer interface [polypeptide binding]; other site 443906006923 MoaD interaction [polypeptide binding]; other site 443906006924 active site residues [active] 443906006925 MogA_MoaB family. Members of this family are involved in biosynthesis of the molybdenum cofactor (MoCF) an essential cofactor of a diverse group of redox enzymes. MoCF biosynthesis is an evolutionarily conserved pathway present in eubacteria, archaea; Region: MogA_MoaB; cd00886 443906006926 MPT binding site; other site 443906006927 trimer interface [polypeptide binding]; other site 443906006928 molybdenum cofactor biosynthesis protein MoaC; Provisional; Region: moaC; PRK09364 443906006929 trimer interface [polypeptide binding]; other site 443906006930 dimer interface [polypeptide binding]; other site 443906006931 putative active site [active] 443906006932 Molybdopterin biosynthesis enzyme [Coenzyme metabolism]; Region: MoeA; COG0303 443906006933 MoeA family. Members of this family are involved in biosynthesis of the molybdenum cofactor (MoCF), an essential cofactor of a diverse group of redox enzymes. MoCF biosynthesis is an evolutionarily conserved pathway present in eubacteria, archaea and...; Region: MoeA; cd00887 443906006934 dimer interface [polypeptide binding]; other site 443906006935 putative functional site; other site 443906006936 putative MPT binding site; other site 443906006937 Phosphoenolpyruvate phosphomutase; Region: PEP_mutase; pfam13714 443906006938 Members of the ICL/PEPM enzyme family catalyze either P-C or C-C bond formation/cleavage. Known members are phosphoenolpyruvate mutase (PEPM), phosphonopyruvate hydrolase (PPH), carboxyPEP mutase (CPEP mutase), oxaloacetate hydrolase (OAH), isocitrate...; Region: ICL_PEPM; cd00377 443906006939 tetramer interface [polypeptide binding]; other site 443906006940 active site 443906006941 Mg2+/Mn2+ binding site [ion binding]; other site 443906006942 Phosphorylase superfamily; Region: PNP_UDP_1; cl00303 443906006943 Nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: WcaG; COG0451 443906006944 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 443906006945 NAD(P) binding site [chemical binding]; other site 443906006946 active site 443906006947 3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05653 443906006948 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 443906006949 NAD(P) binding site [chemical binding]; other site 443906006950 active site 443906006951 Stress responsive A/B Barrel Domain; Region: Dabb; smart00886 443906006952 Predicted permease; Region: DUF318; cl17795 443906006953 TIGR03943 family protein; Region: TIGR03943 443906006954 Cupin domain; Region: Cupin_2; cl17218 443906006955 Predicted transcriptional regulators [Transcription]; Region: COG1695 443906006956 Transcriptional regulator PadR-like family; Region: PadR; pfam03551 443906006957 Sulfite oxidase (SO) family, molybdopterin binding domain. This molybdopterin cofactor (Moco) binding domain is found in a variety of oxidoreductases, main members of this family are nitrate reductase (NR) and sulfite oxidase (SO). SO catalyzes the...; Region: SO_family_Moco; cl00199 443906006958 Sulfite oxidase and related enzymes [General function prediction only]; Region: COG2041 443906006959 Moco binding site; other site 443906006960 metal coordination site [ion binding]; other site 443906006961 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 443906006962 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 443906006963 dimer interface [polypeptide binding]; other site 443906006964 phosphorylation site [posttranslational modification] 443906006965 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 443906006966 ATP binding site [chemical binding]; other site 443906006967 Mg2+ binding site [ion binding]; other site 443906006968 G-X-G motif; other site 443906006969 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 443906006970 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 443906006971 active site 443906006972 phosphorylation site [posttranslational modification] 443906006973 intermolecular recognition site; other site 443906006974 dimerization interface [polypeptide binding]; other site 443906006975 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 443906006976 DNA binding site [nucleotide binding] 443906006977 DPM_DPG-synthase_like is a member of the Glycosyltransferase 2 superfamily; Region: DPM_DPG-synthase_like; cd04179 443906006978 Ligand binding site; other site 443906006979 Putative Catalytic site; other site 443906006980 DXD motif; other site 443906006981 Uncharacterized protein conserved in bacteria (DUF2064); Region: DUF2064; cl17492 443906006982 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl17173 443906006983 Sulfite oxidase and related enzymes [General function prediction only]; Region: COG2041 443906006984 Sulfite oxidase (SO) family, molybdopterin binding domain. This molybdopterin cofactor (Moco) binding domain is found in a variety of oxidoreductases, main members of this family are nitrate reductase (NR) and sulfite oxidase (SO). SO catalyzes the...; Region: SO_family_Moco; cd00321 443906006985 Moco binding site; other site 443906006986 metal coordination site [ion binding]; other site 443906006987 Protein of unknown function (DUF2029); Region: DUF2029; pfam09594 443906006988 glycerol-3-phosphate transporter ATP-binding subunit; Provisional; Region: ugpC; PRK11650 443906006989 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 443906006990 Walker A/P-loop; other site 443906006991 ATP binding site [chemical binding]; other site 443906006992 Q-loop/lid; other site 443906006993 ABC transporter signature motif; other site 443906006994 Walker B; other site 443906006995 D-loop; other site 443906006996 H-loop/switch region; other site 443906006997 ABC-type sulfate transport system, permease component [Posttranslational modification, protein turnover, chaperones]; Region: CysU; COG0555 443906006998 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 443906006999 putative PBP binding loops; other site 443906007000 ABC-ATPase subunit interface; other site 443906007001 Bacterial extracellular solute-binding protein; Region: SBP_bac_11; pfam13531 443906007002 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; cl17199 443906007003 Helix-Turn-Helix DNA binding domain of transcription regulators from the MerR superfamily; Region: HTH_MerR-SF; cl02600 443906007004 DNA binding residues [nucleotide binding] 443906007005 Molybdopterin-binding protein [Coenzyme metabolism]; Region: MopI; COG3585 443906007006 molybdenum cofactor biosynthesis protein A; Reviewed; Region: moaA; PRK00164 443906007007 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 443906007008 FeS/SAM binding site; other site 443906007009 Molybdenum Cofactor Synthesis C; Region: Mob_synth_C; pfam06463 443906007010 Siderophore-interacting protein [Inorganic ion transport and metabolism]; Region: ViuB; COG2375 443906007011 Siderophore interacting proteins share the domain structure of the ferredoxin reductase like family. Siderophores are produced in various bacteria (and some plants) to extract iron from hosts. Binding constants are high, so iron can be pilfered from...; Region: siderophore_interacting; cd06193 443906007012 FAD binding pocket [chemical binding]; other site 443906007013 FAD binding motif [chemical binding]; other site 443906007014 phosphate binding motif [ion binding]; other site 443906007015 NAD binding pocket [chemical binding]; other site 443906007016 ABC-type Fe3+-hydroxamate transport system, periplasmic component [Inorganic ion transport and metabolism]; Region: FepB; COG0614 443906007017 Helical backbone metal receptor (TroA-like domain). These proteins have been shown to function in the ABC transport of ferric siderophores and metal ions such as Mn2+, Fe3+, Cu2+ and/or Zn2+. Their ligand binding site is formed in the interface between...; Region: TroA-like; cl00262 443906007018 intersubunit interface [polypeptide binding]; other site 443906007019 iron-hydroxamate transporter permease subunit; Provisional; Region: PRK10577 443906007020 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550 443906007021 ABC-ATPase subunit interface; other site 443906007022 dimer interface [polypeptide binding]; other site 443906007023 putative PBP binding regions; other site 443906007024 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cl00462 443906007025 ABC-ATPase subunit interface; other site 443906007026 dimer interface [polypeptide binding]; other site 443906007027 putative PBP binding regions; other site 443906007028 Escherichia coli PhnB and similar proteins; the E. coli phnB gene is found next to an operon involved in the cleavage of carbon-phosphorus bonds in unactivated alkylphosphonates; Region: PhnB_like; cd06588 443906007029 dimer interface [polypeptide binding]; other site 443906007030 Protein of unknown function (DUF1648); Region: DUF1648; pfam07853 443906007031 Predicted transcriptional regulators [Transcription]; Region: COG1725 443906007032 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 443906007033 DNA-binding site [nucleotide binding]; DNA binding site 443906007034 Transcriptional regulators [Transcription]; Region: PurR; COG1609 443906007035 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 443906007036 DNA binding site [nucleotide binding] 443906007037 domain linker motif; other site 443906007038 Ligand binding domain of the LacI tanscriptional regulator family belonging to the type I periplasmic-binding fold protein superfamily; Region: PBP1_LacI_sugar_binding_like; cd06267 443906007039 ligand binding site [chemical binding]; other site 443906007040 dimerization interface [polypeptide binding]; other site 443906007041 Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673 443906007042 Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408 443906007043 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 443906007044 active site 443906007045 Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248 443906007046 catalytic tetrad [active] 443906007047 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 443906007048 putative DNA binding site [nucleotide binding]; other site 443906007049 dimerization interface [polypeptide binding]; other site 443906007050 Transcriptional regulators [Transcription]; Region: MarR; COG1846 443906007051 putative Zn2+ binding site [ion binding]; other site 443906007052 MarR family; Region: MarR_2; pfam12802 443906007053 MarR family; Region: MarR_2; cl17246 443906007054 hypothetical protein; Validated; Region: PRK07411 443906007055 ThiF_MoeB_HesA. Family of E1-like enzymes involved in molybdopterin and thiamine biosynthesis family. The common reaction mechanism catalyzed by MoeB and ThiF, like other E1 enzymes, begins with a nucleophilic attack of the C-terminal carboxylate of MoaD...; Region: ThiF_MoeB_HesA_family; cd00757 443906007056 ATP binding site [chemical binding]; other site 443906007057 substrate interface [chemical binding]; other site 443906007058 Rhodanese Homology Domain (RHOD); an alpha beta fold domain found duplicated in the rhodanese protein. The cysteine containing enzymatically active version of the domain is also found in the Cdc25 class of protein phosphatases and a variety of proteins...; Region: RHOD; cd00158 443906007059 active site residue [active] 443906007060 Dolichyl-phosphate-mannose-protein mannosyltransferase; Region: PMT_2; cl17364 443906007061 haloalkane dehalogenase; Provisional; Region: PRK03592 443906007062 Putative lysophospholipase; Region: Hydrolase_4; pfam12146 443906007063 CGNR zinc finger; Region: zf-CGNR; pfam11706 443906007064 4-diphosphocytidyl-2-C-methyl-D-erythritol kinase; Provisional; Region: PRK03188 443906007065 GHMP kinases C terminal; Region: GHMP_kinases_C; pfam08544 443906007066 16S ribosomal RNA methyltransferase KsgA/Dim1 family protein; Reviewed; Region: ksgA; PRK00274 443906007067 Dimethyladenosine transferase (rRNA methylation) [Translation, ribosomal structure and biogenesis]; Region: KsgA; COG0030 443906007068 TatD like proteins; E.coli TatD is a cytoplasmic protein, shown to have magnesium dependent DNase activity; Region: TatD_DNAse; cd01310 443906007069 active site 443906007070 methionyl-tRNA synthetase; Reviewed; Region: PRK11893 443906007071 catalytic core domain of methioninyl-tRNA synthetases; Region: MetRS_core; cd00814 443906007072 active site 443906007073 HIGH motif; other site 443906007074 KMSKS motif; other site 443906007075 Anticodon-binding domain of methionyl tRNA synthetases; Region: Anticodon_Ia_Met; cd07957 443906007076 tRNA binding surface [nucleotide binding]; other site 443906007077 anticodon binding site; other site 443906007078 citrate synthase; Provisional; Region: PRK14033 443906007079 Citrate synthase (CS), citryl-CoA lyase (CCL), the C-terminal portion of the single-subunit type ATP-citrate lyase (ACL) and the C-terminal portion of the large subunit of the two-subunit type ACL. CS catalyzes the condensation of acetyl coenzyme A; Region: CS_ACL-C_CCL; cl00416 443906007080 oxalacetate binding site [chemical binding]; other site 443906007081 citrylCoA binding site [chemical binding]; other site 443906007082 coenzyme A binding site [chemical binding]; other site 443906007083 catalytic triad [active] 443906007084 Pyruvate/2-oxoglutarate dehydrogenase complex, dihydrolipoamide dehydrogenase (E3) component, and related enzymes [Energy production and conversion]; Region: Lpd; COG1249 443906007085 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500 443906007086 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 443906007087 Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain; Region: Pyr_redox_dim; pfam02852 443906007088 Flavodoxin-like fold; Region: Flavodoxin_2; pfam02525 443906007089 Cinnamyl alcohol dehydrogenases (CAD); Region: CAD1; cd05283 443906007090 Zn-dependent alcohol dehydrogenases [General function prediction only]; Region: AdhP; COG1064 443906007091 putative NAD(P) binding site [chemical binding]; other site 443906007092 putative substrate binding site [chemical binding]; other site 443906007093 catalytic Zn binding site [ion binding]; other site 443906007094 structural Zn binding site [ion binding]; other site 443906007095 dimer interface [polypeptide binding]; other site 443906007096 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 443906007097 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 443906007098 Protein of unknown function (DUF3021); Region: DUF3021; pfam11457 443906007099 RNA repair, ligase-Pnkp-associating, region of Hen1; Region: Hen1_L; pfam12623 443906007100 3' terminal RNA ribose 2'-O-methyltransferase Hen1; Region: bacter_Hen1; TIGR04074 443906007101 Methyltransferase domain; Region: Methyltransf_12; pfam08242 443906007102 polynucleotide kinase-phosphatase; Region: bacter_Pnkp; TIGR04075 443906007103 metallophosphatase superfamily, metallophosphatase domain; Region: MPP_superfamily; cl13995 443906007104 active site 443906007105 metal binding site [ion binding]; metal-binding site 443906007106 Phosphoenolpyruvate phosphomutase; Region: PEP_mutase; pfam13714 443906007107 Members of the ICL/PEPM enzyme family catalyze either P-C or C-C bond formation/cleavage. Known members are phosphoenolpyruvate mutase (PEPM), phosphonopyruvate hydrolase (PPH), carboxyPEP mutase (CPEP mutase), oxaloacetate hydrolase (OAH), isocitrate...; Region: ICL_PEPM; cd00377 443906007108 tetramer interface [polypeptide binding]; other site 443906007109 active site 443906007110 Mg2+/Mn2+ binding site [ion binding]; other site 443906007111 Uncharacterized protein involved in propionate catabolism [General function prediction only]; Region: PrpD; COG2079 443906007112 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl17182 443906007113 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 443906007114 Coenzyme A binding pocket [chemical binding]; other site 443906007115 MAC/Perforin domain; Region: MACPF; cl02616 443906007116 Protein of unknown function (DUF2464); Region: DUF2464; pfam10240 443906007117 Protein of unknown function (DUF1349); Region: DUF1349; pfam07081 443906007118 maltose O-acetyltransferase; Provisional; Region: PRK10092 443906007119 Maltose O-acetyltransferase (MAT) and Galactoside O-acetyltransferase (GAT): MAT and GAT catalyze the CoA-dependent acetylation of the 6-hydroxyl group of their respective sugar substrates. MAT acetylates maltose and glucose exclusively at the C6...; Region: LbH_MAT_GAT; cd03357 443906007120 active site 443906007121 substrate binding site [chemical binding]; other site 443906007122 trimer interface [polypeptide binding]; other site 443906007123 CoA binding site [chemical binding]; other site 443906007124 transcriptional repressor BetI; Region: betaine_BetI; TIGR03384 443906007125 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 443906007126 Bacterial transcriptional repressor; Region: TetR_C_6; pfam13977 443906007127 Tyrosine phosphatase family; Region: Y_phosphatase3; pfam13350 443906007128 Protein tyrosine phosphatases (PTP) catalyze the dephosphorylation of phosphotyrosine peptides; they regulate phosphotyrosine levels in signal transduction pathways. The depth of the active site cleft renders the enzyme specific for phosphorylated Tyr; Region: PTPc; cl00053 443906007129 active site 443906007130 Tyrosine phosphatase family C-terminal region; Region: Y_phosphatase3C; pfam13348 443906007131 Sortases are cysteine transpeptidases, found in gram-positive bacteria, that anchor surface proteins to peptidoglycans of the bacterial cell wall envelope. They do so by catalyzing a transpeptidation reaction in which the surface protein substrate is...; Region: Sortase; cl09098 443906007132 active site 443906007133 catalytic site [active] 443906007134 Predicted membrane protein [Function unknown]; Region: COG4129 443906007135 Carboxylate/Amino Acid/Amine Transporter; Region: 2A78; TIGR00950 443906007136 Protein of unknown function (DUF1470); Region: DUF1470; pfam07336 443906007137 CGNR zinc finger; Region: zf-CGNR; pfam11706 443906007138 Predicted methyltransferases [General function prediction only]; Region: COG0313 443906007139 Ribosomal RNA small subunit methyltransferase I, also known as rRNA (cytidine-2'-O-)-methyltransferase RsmI; Region: RsmI; cd11648 443906007140 putative SAM binding site [chemical binding]; other site 443906007141 putative homodimer interface [polypeptide binding]; other site 443906007142 Predicted membrane protein [Function unknown]; Region: COG2259 443906007143 trehalose synthase, Pseudomonas stutzeri type; Region: TreS_stutzeri; TIGR02455 443906007144 Dolichyl-phosphate-mannose-protein mannosyltransferase; Region: PMT_2; cl17364 443906007145 Conserved hypothetical protein 698; Region: Cons_hypoth698; cl01075 443906007146 O-acetylhomoserine sulfhydrylase [Amino acid transport and metabolism]; Region: MET17; COG2873 443906007147 CGS_like: Cystathionine gamma-synthase is a PLP dependent enzyme and catalyzes the committed step of methionine biosynthesis. This pathway is unique to microorganisms and plants, rendering the enzyme an attractive target for the development of...; Region: CGS_like; cd00614 443906007148 homodimer interface [polypeptide binding]; other site 443906007149 substrate-cofactor binding pocket; other site 443906007150 pyridoxal 5'-phosphate binding site [chemical binding]; other site 443906007151 catalytic residue [active] 443906007152 Predicted CoA-binding protein [General function prediction only]; Region: COG1832 443906007153 Domain of unknown function (DUF427); Region: DUF427; pfam04248 443906007154 L-serine dehydratase, iron-sulfur-dependent, single chain form; Region: sda_mono; TIGR00720 443906007155 Serine dehydratase beta chain; Region: SDH_beta; pfam03315 443906007156 Serine dehydratase alpha chain; Region: SDH_alpha; pfam03313 443906007157 SdpI/YhfL protein family; Region: SdpI; pfam13630 443906007158 Transcriptional regulator [Transcription]; Region: IclR; COG1414 443906007159 IclR helix-turn-helix domain; Region: HTH_IclR; cl17605 443906007160 Bacterial transcriptional regulator; Region: IclR; pfam01614 443906007161 Nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: WcaG; COG0451 443906007162 extended (e) SDRs; Region: SDR_e; cd08946 443906007163 NAD(P) binding site [chemical binding]; other site 443906007164 active site 443906007165 substrate binding site [chemical binding]; other site 443906007166 ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653 443906007167 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; pfam01547 443906007168 ABC-type polysaccharide transport system, permease component [Carbohydrate transport and metabolism]; Region: LplB; COG4209 443906007169 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 443906007170 putative PBP binding loops; other site 443906007171 ABC-ATPase subunit interface; other site 443906007172 ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395 443906007173 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 443906007174 dimer interface [polypeptide binding]; other site 443906007175 conserved gate region; other site 443906007176 putative PBP binding loops; other site 443906007177 ABC-ATPase subunit interface; other site 443906007178 glucarate dehydratase; Region: glucar-dehydr; TIGR03247 443906007179 Enolase-superfamily, characterized by the presence of an enolate anion intermediate which is generated by abstraction of the alpha-proton of the carboxylate substrate by an active site residue and is stabilized by coordination to the essential Mg2+ ion; Region: enolase_like; cl17188 443906007180 metal binding site [ion binding]; metal-binding site 443906007181 substrate binding pocket [chemical binding]; other site 443906007182 5-dehydro-4-deoxyglucarate dehydratase; Provisional; Region: PRK03620 443906007183 Dihydrodipicolinate synthase/N-acetylneuraminate lyase [Amino acid transport and metabolism / Cell envelope biogenesis, outer membrane]; Region: DapA; COG0329 443906007184 catalytic residue [active] 443906007185 Highly conserved protein containing a thioredoxin domain [Posttranslational modification, protein turnover, chaperones]; Region: COG1331 443906007186 TRX domain, SSP411 protein family; members of this family are highly conserved proteins present in eukaryotes, bacteria and archaea, about 600-800 amino acids in length, which contain a TRX domain with a redox active CXXC motif. The human/rat protein; Region: SSP411; cd02955 443906007187 catalytic residues [active] 443906007188 Mg2+ and Co2+ transporters [Inorganic ion transport and metabolism]; Region: CorA; COG0598 443906007189 Mycobacterium tuberculosis CorA-like subfamily; Region: MtCorA-like; cd12830 443906007190 oligomer interface [polypeptide binding]; other site 443906007191 metal binding site [ion binding]; metal-binding site 443906007192 metal binding site [ion binding]; metal-binding site 443906007193 putative Cl binding site [ion binding]; other site 443906007194 basic sphincter; other site 443906007195 hydrophobic gate; other site 443906007196 periplasmic entrance; other site 443906007197 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 443906007198 Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248 443906007199 active site 443906007200 catalytic tetrad [active] 443906007201 long-chain-fatty-acid--CoA ligase; Validated; Region: PRK07656 443906007202 Prokaryotic long-chain fatty acid CoA synthetases similar to Escherichia coli FadD; Region: FC-FACS_FadD_like; cd05936 443906007203 acyl-activating enzyme (AAE) consensus motif; other site 443906007204 putative AMP binding site [chemical binding]; other site 443906007205 putative active site [active] 443906007206 putative CoA binding site [chemical binding]; other site 443906007207 ATP-dependent RNA helicase HrpA; Provisional; Region: PRK11131 443906007208 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 443906007209 ATP binding site [chemical binding]; other site 443906007210 putative Mg++ binding site [ion binding]; other site 443906007211 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 443906007212 nucleotide binding region [chemical binding]; other site 443906007213 ATP-binding site [chemical binding]; other site 443906007214 Helicase associated domain (HA2); Region: HA2; pfam04408 443906007215 Oligonucleotide/oligosaccharide-binding (OB)-fold; Region: OB_NTP_bind; pfam07717 443906007216 Domain of unknown function (DUF3418); Region: DUF3418; pfam11898 443906007217 The substrate-binding component of an uncharacterized ABC-type nickel/dipeptide/oligopeptide-like import system contains the type 2 periplasmic binding fold; Region: PBP2_NikA_DppA_OppA_like_17; cd08503 443906007218 Bacterial extracellular solute-binding proteins, family 5 Middle; Region: SBP_bac_5; pfam00496 443906007219 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppB; COG0601 443906007220 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cl00427 443906007221 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cl00427 443906007222 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppC; COG1173 443906007223 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cl00427 443906007224 ATPase components of various ABC-type transport systems, contain duplicated ATPase [General function prediction only]; Region: COG1123 443906007225 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 443906007226 Walker A/P-loop; other site 443906007227 ATP binding site [chemical binding]; other site 443906007228 Q-loop/lid; other site 443906007229 ABC transporter signature motif; other site 443906007230 Walker B; other site 443906007231 D-loop; other site 443906007232 H-loop/switch region; other site 443906007233 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 443906007234 Walker A/P-loop; other site 443906007235 ATP binding site [chemical binding]; other site 443906007236 Q-loop/lid; other site 443906007237 ABC transporter signature motif; other site 443906007238 Walker B; other site 443906007239 D-loop; other site 443906007240 H-loop/switch region; other site 443906007241 Thiosulfate sulfurtransferase (TST), N-terminal, inactive domain. TST contains 2 copies of the Rhodanese Homology Domain; this is the 1st repeat, which does not contain the catalytically active Cys residue. The role of the 1st repeat is uncertain, but it...; Region: TST_Repeat_1; cd01448 443906007242 Rhodanese-related sulfurtransferase [Inorganic ion transport and metabolism]; Region: SseA; COG2897 443906007243 active site residue [active] 443906007244 Thiosulfate sulfurtransferase (TST), C-terminal, catalytic domain. TST contains 2 copies of the Rhodanese Homology Domain; this is the second repeat. Only the second repeat contains the catalytically active Cys residue; Region: TST_Repeat_2; cd01449 443906007245 active site residue [active] 443906007246 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 443906007247 Coenzyme A binding pocket [chemical binding]; other site 443906007248 Ribonucleotide Reductase, R2/beta subunit, ferritin-like diiron-binding domain; Region: RNRR2; cd01049 443906007249 dimer interface [polypeptide binding]; other site 443906007250 putative radical transfer pathway; other site 443906007251 diiron center [ion binding]; other site 443906007252 tyrosyl radical; other site 443906007253 ribonucleotide-diphosphate reductase subunit alpha; Validated; Region: PRK06539 443906007254 ATP cone domain; Region: ATP-cone; pfam03477 443906007255 Class I ribonucleotide reductase; Region: RNR_I; cd01679 443906007256 active site 443906007257 dimer interface [polypeptide binding]; other site 443906007258 catalytic residues [active] 443906007259 effector binding site; other site 443906007260 R2 peptide binding site; other site 443906007261 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 443906007262 putative substrate translocation pore; other site 443906007263 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 443906007264 Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248 443906007265 active site 443906007266 catalytic tetrad [active] 443906007267 Totivirus coat protein; Region: Totivirus_coat; pfam05518 443906007268 Trypsin-like peptidase domain; Region: Trypsin_2; pfam13365 443906007269 PDZ domain of tryspin-like serine proteases, such as DegP/HtrA, which are oligomeric proteins involved in heat-shock response, chaperone function, and apoptosis. May be responsible for substrate recognition and/or binding, as most PDZ domains bind...; Region: PDZ_serine_protease; cd00987 443906007270 protein binding site [polypeptide binding]; other site 443906007271 Alpha-L-arabinofuranosidase [Carbohydrate transport and metabolism]; Region: AbfA; COG3534 443906007272 Alpha-L-arabinofuranosidase C-terminus; Region: Alpha-L-AF_C; pfam06964 443906007273 ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395 443906007274 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 443906007275 dimer interface [polypeptide binding]; other site 443906007276 conserved gate region; other site 443906007277 putative PBP binding loops; other site 443906007278 ABC-ATPase subunit interface; other site 443906007279 ABC-type spermidine/putrescine transport system, permease component II [Amino acid transport and metabolism]; Region: PotC; COG1177 443906007280 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 443906007281 dimer interface [polypeptide binding]; other site 443906007282 ABC-ATPase subunit interface; other site 443906007283 putative PBP binding loops; other site 443906007284 ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653 443906007285 Transcriptional regulators [Transcription]; Region: PurR; COG1609 443906007286 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 443906007287 DNA binding site [nucleotide binding] 443906007288 domain linker motif; other site 443906007289 Ligand binding domain of the LacI tanscriptional regulator family belonging to the type I periplasmic-binding fold protein superfamily; Region: PBP1_LacI_sugar_binding_like; cd06267 443906007290 dimerization interface [polypeptide binding]; other site 443906007291 ligand binding site [chemical binding]; other site 443906007292 Protein of unknown function (DUF3054); Region: DUF3054; pfam11255 443906007293 Methylase of polypeptide chain release factors [Translation, ribosomal structure and biogenesis]; Region: HemK; COG2890 443906007294 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 443906007295 S-adenosylmethionine binding site [chemical binding]; other site 443906007296 Endoglucanase [Carbohydrate transport and metabolism]; Region: BglC; COG2730 443906007297 Cellulase (glycosyl hydrolase family 5); Region: Cellulase; pfam00150 443906007298 CBD_II domain; Region: CBD_II; smart00637 443906007299 Acetyltransferases, including N-acetylases of ribosomal proteins [Translation, ribosomal structure and biogenesis]; Region: RimL; COG1670 443906007300 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl17182 443906007301 Prokaryotic UGPase catalyses the synthesis of UDP-glucose; Region: UGPase_prokaryotic; cd02541 443906007302 dTDP-glucose pyrophosphorylase [Cell envelope biogenesis, outer membrane]; Region: RfbA; COG1209 443906007303 active site 443906007304 tetramer interface; other site 443906007305 5-formyltetrahydrofolate cyclo-ligase family; Region: 5-FTHF_cyc-lig; pfam01812 443906007306 5,10-methenyltetrahydrofolate synthetase; Region: MTHFS_bact; TIGR02727 443906007307 Zinc ribbon domain; Region: CxxC_CxxC_SSSS; cl00993 443906007308 Large-conductance mechanosensitive channel [Cell envelope biogenesis, outer membrane]; Region: MscL; COG1970 443906007309 large-conductance mechanosensitive channel; Reviewed; Region: mscL; PRK00567 443906007310 Protein of unknown function (DUF4011); Region: DUF4011; pfam13195 443906007311 Part of AAA domain; Region: AAA_19; pfam13245 443906007312 Superfamily I DNA and RNA helicases and helicase subunits [DNA replication, recombination, and repair]; Region: COG1112 443906007313 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 443906007314 sequence-specific DNA binding site [nucleotide binding]; other site 443906007315 salt bridge; other site 443906007316 Nucleotidyltransferase (NT) domain of Staphylococcus aureus kanamycin nucleotidyltransferase, and similar proteins; Region: NT_KNTase_like; cd05403 443906007317 active site 443906007318 NTP binding site [chemical binding]; other site 443906007319 metal binding triad [ion binding]; metal-binding site 443906007320 antibiotic binding site [chemical binding]; other site 443906007321 Protein of unknown function DUF86; Region: DUF86; cl01031 443906007322 Uncharacterized conserved protein [Function unknown]; Region: COG4748 443906007323 Type I restriction enzyme R protein N terminus (HSDR_N); Region: HSDR_N; cl14958 443906007324 Solute carrier families 5 and 6-like; solute binding domain; Region: SLC5-6-like_sbd; cl00456 443906007325 Permease for cytosine/purines, uracil, thiamine, allantoin; Region: Transp_cyt_pur; pfam02133 443906007326 Na binding site [ion binding]; other site 443906007327 N-methylhydantoinase A/acetone carboxylase, beta subunit [Amino acid transport and metabolism / Secondary metabolites biosynthesis, transport, and catabolism]; Region: HyuA; COG0145 443906007328 Hydantoinase/oxoprolinase N-terminal region; Region: Hydant_A_N; pfam05378 443906007329 Hydantoinase/oxoprolinase; Region: Hydantoinase_A; pfam01968 443906007330 Protein of unknown function (DUF917); Region: DUF917; pfam06032 443906007331 Protein of unknown function (DUF917); Region: DUF917; cl17829 443906007332 PucR C-terminal helix-turn-helix domain; Region: HTH_30; pfam13556 443906007333 Protein of unknown function (DUF2510); Region: DUF2510; pfam10708 443906007334 Domain of unknown function (DUF4041); Region: DUF4041; pfam13250 443906007335 This entry represents the putative helicase A859L; Region: T5orf172; smart00974 443906007336 Telomere recombination; Region: Sua5_yciO_yrdC; cl00305 443906007337 Lsr2; Region: Lsr2; pfam11774 443906007338 Bacterial transcriptional activator domain; Region: BTAD; smart01043 443906007339 Serine proteases of the peptidase family S9A [Amino acid transport and metabolism]; Region: COG1505 443906007340 Prolyl oligopeptidase family; Region: Peptidase_S9; pfam00326 443906007341 Restriction endonuclease [Defense mechanisms]; Region: McrA; COG1403 443906007342 HNH nucleases; HNH endonuclease signature which is found in viral, prokaryotic, and eukaryotic proteins. The alignment includes members of the large group of homing endonucleases, yeast intron 1 protein, MutS, as well as bacterial colicins, pyocins, and...; Region: HNHc; cd00085 443906007343 active site 443906007344 Cell wall-associated hydrolases (invasion-associated proteins) [Cell envelope biogenesis, outer membrane]; Region: Spr; COG0791 443906007345 NlpC/P60 family; Region: NLPC_P60; pfam00877 443906007346 Iron dependent repressor, N-terminal DNA binding domain; Region: Fe_dep_repress; pfam01325 443906007347 Helix-turn-helix diphteria tox regulatory element; Region: HTH_DTXR; smart00529 443906007348 Iron dependent repressor, metal binding and dimerisation domain; Region: Fe_dep_repr_C; pfam02742 443906007349 This entry represents the core domain of the ferrous iron (Fe2+) transport protein FeoA found in bacteria; Region: FeoA; smart00899 443906007350 phosphoserine aminotransferase; Provisional; Region: PRK03080 443906007351 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 443906007352 catalytic residue [active] 443906007353 Protein of unknown function (DUF3027); Region: DUF3027; pfam11228 443906007354 Cold-Shock Protein (CSP) contains an S1-like cold-shock domain (CSD) that is found in eukaryotes, prokaryotes, and archaea. CSP's include the major cold-shock proteins CspA and CspB in bacteria and the eukaryotic gene regulatory factor Y-box...; Region: CSP_CDS; cd04458 443906007355 DNA-binding site [nucleotide binding]; DNA binding site 443906007356 RNA-binding motif; other site 443906007357 Helicase conserved C-terminal domain; Region: Helicase_C_3; pfam13625 443906007358 Helicase conserved C-terminal domain; Region: Helicase_C_3; pfam13625 443906007359 DNA or RNA helicases of superfamily II [Transcription / DNA replication, recombination, and repair]; Region: SSL2; COG1061 443906007360 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 443906007361 ATP binding site [chemical binding]; other site 443906007362 putative Mg++ binding site [ion binding]; other site 443906007363 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 443906007364 nucleotide binding region [chemical binding]; other site 443906007365 ATP-binding site [chemical binding]; other site 443906007366 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 443906007367 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 443906007368 active site 443906007369 phosphorylation site [posttranslational modification] 443906007370 intermolecular recognition site; other site 443906007371 dimerization interface [polypeptide binding]; other site 443906007372 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 443906007373 DNA binding site [nucleotide binding] 443906007374 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 443906007375 dimerization interface [polypeptide binding]; other site 443906007376 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 443906007377 dimer interface [polypeptide binding]; other site 443906007378 phosphorylation site [posttranslational modification] 443906007379 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 443906007380 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 443906007381 ATP binding site [chemical binding]; other site 443906007382 Mg2+ binding site [ion binding]; other site 443906007383 G-X-G motif; other site 443906007384 WXG100 family type VII secretion target; Region: WXG100_ESAT6; TIGR03930 443906007385 chaperonin GroEL; Reviewed; Region: groEL; PRK12849 443906007386 GroEL_like type I chaperonin. Chaperonins are involved in productive folding of proteins. They share a common general morphology, a double toroid of 2 stacked rings, each composed of 7-9 subunits. The symmetry of type I is seven-fold and they are found...; Region: GroEL; cd03344 443906007387 ring oligomerisation interface [polypeptide binding]; other site 443906007388 ATP/Mg binding site [chemical binding]; other site 443906007389 stacking interactions; other site 443906007390 hinge regions; other site 443906007391 Cold-Shock Protein (CSP) contains an S1-like cold-shock domain (CSD) that is found in eukaryotes, prokaryotes, and archaea. CSP's include the major cold-shock proteins CspA and CspB in bacteria and the eukaryotic gene regulatory factor Y-box...; Region: CSP_CDS; cd04458 443906007392 DNA-binding site [nucleotide binding]; DNA binding site 443906007393 RNA-binding motif; other site 443906007394 LytR cell envelope-related transcriptional attenuator; Region: LytR_C; pfam13399 443906007395 Protein of unknown function (DUF3263); Region: DUF3263; pfam11662 443906007396 methionine sulfoxide reductase B; Provisional; Region: PRK00222 443906007397 SelR domain; Region: SelR; pfam01641 443906007398 Nitroreductase-like family which includes NADH oxidase and arsenite oxidiase. NADH oxidase catalyses the oxidation of NAD(P)H and accepts a wide broad range of compounds as electron acceptors, such as nitrocompound. Arsenite oxidase in a...; Region: Arsenite_oxidase; cd02135 443906007399 putative FMN binding site [chemical binding]; other site 443906007400 Thioredoxin; Region: Thioredoxin_4; cl17273 443906007401 glycerol-3-phosphate transporter ATP-binding subunit; Provisional; Region: ugpC; PRK11650 443906007402 The N-terminal ATPase domain of the maltose transporter, MalK; Region: ABC_MalK_N; cd03301 443906007403 Walker A/P-loop; other site 443906007404 ATP binding site [chemical binding]; other site 443906007405 Q-loop/lid; other site 443906007406 ABC transporter signature motif; other site 443906007407 Walker B; other site 443906007408 D-loop; other site 443906007409 H-loop/switch region; other site 443906007410 TOBE domain; Region: TOBE_2; pfam08402 443906007411 Domain of unknown function (DUF4032); Region: DUF4032; pfam13224 443906007412 rRNA methylases [Translation, ribosomal structure and biogenesis]; Region: SpoU; COG0566 443906007413 RNA 2'-O ribose methyltransferase substrate binding; Region: SpoU_sub_bind; pfam08032 443906007414 SpoU rRNA Methylase family; Region: SpoU_methylase; pfam00588 443906007415 cysteinyl-tRNA synthetase; Validated; Region: cysS; PRK00260 443906007416 nucleotidyl transferase superfamily; Region: nt_trans; cl00015 443906007417 active site 443906007418 HIGH motif; other site 443906007419 nucleotide binding site [chemical binding]; other site 443906007420 catalytic core domain of cysteinyl tRNA synthetase; Region: CysRS_core; cd00672 443906007421 KMSKS motif; other site 443906007422 Anticodon-binding domain of class Ia aminoacyl tRNA synthetases and similar domains; Region: Anticodon_Ia_like; cl12020 443906007423 bifunctional 2-C-methyl-D-erythritol 4-phosphate cytidylyltransferase/2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase protein; Provisional; Region: ispDF; PRK09382 443906007424 CDP-ME synthetase is involved in mevalonate-independent isoprenoid production; Region: CDP-ME_synthetase; cd02516 443906007425 substrate binding site; other site 443906007426 dimer interface; other site 443906007427 MECDP_synthase (2-C-methyl-D-erythritol-2,4-cyclodiphosphate synthase), encoded by the ispF gene, catalyzes the formation of 2-C-methyl-D-erythritol 2,4-cyclodiphosphate (MEC) in the non-mevalonate deoxyxylulose (DOXP) pathway for isoprenoid biosynthesis; Region: MECDP_synthase; cd00554 443906007428 homotrimer interaction site [polypeptide binding]; other site 443906007429 zinc binding site [ion binding]; other site 443906007430 CDP-binding sites; other site 443906007431 Transcriptional regulators, similar to M. xanthus CarD [Transcription]; Region: COG1329 443906007432 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 443906007433 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 443906007434 active site 443906007435 phosphorylation site [posttranslational modification] 443906007436 intermolecular recognition site; other site 443906007437 dimerization interface [polypeptide binding]; other site 443906007438 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 443906007439 DNA binding site [nucleotide binding] 443906007440 phosphate regulon sensor kinase PhoR; Region: phoR_proteo; TIGR02966 443906007441 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 443906007442 dimer interface [polypeptide binding]; other site 443906007443 phosphorylation site [posttranslational modification] 443906007444 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 443906007445 ATP binding site [chemical binding]; other site 443906007446 Mg2+ binding site [ion binding]; other site 443906007447 G-X-G motif; other site 443906007448 phosphate transport system regulatory protein PhoU; Region: phoU_full; TIGR02135 443906007449 PhoU domain; Region: PhoU; pfam01895 443906007450 PhoU domain; Region: PhoU; pfam01895 443906007451 Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067 443906007452 catalytic core [active] 443906007453 Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067 443906007454 Methyltransferase domain; Region: Methyltransf_18; pfam12847 443906007455 Predicted membrane protein [Function unknown]; Region: COG4129 443906007456 Predicted aminomethyltransferase related to GcvT [General function prediction only]; Region: COG0354 443906007457 folate-binding protein YgfZ; Region: ygfZ_signature; TIGR03317 443906007458 Glycine cleavage T-protein C-terminal barrel domain; Region: GCV_T_C; pfam08669 443906007459 nitrobindin heme-binding domain; Region: nitrobindin; cd07828 443906007460 heme-binding site [chemical binding]; other site 443906007461 DNA-binding response regulator CreB; Provisional; Region: PRK11083 443906007462 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 443906007463 DNA binding site [nucleotide binding] 443906007464 mycothiol synthase; Region: mycothiol_MshD; TIGR03448 443906007465 polyphosphate kinase; Provisional; Region: PRK05443 443906007466 Polyphosphate kinase N-terminal domain; Region: PP_kinase_N; pfam13089 443906007467 Polyphosphate kinase middle domain; Region: PP_kinase; pfam02503 443906007468 Catalytic C-terminal domain, first repeat, of Pseudomonas aeruginosa polyphosphate kinase 1 and similar proteins; Region: PLDc_PaPPK1_C1_like; cd09165 443906007469 putative domain interface [polypeptide binding]; other site 443906007470 putative active site [active] 443906007471 catalytic site [active] 443906007472 Catalytic C-terminal domain, second repeat, of Pseudomonas aeruginosa polyphosphate kinase 1 and similar proteins; Region: PLDc_PaPPK1_C2_like; cd09168 443906007473 putative domain interface [polypeptide binding]; other site 443906007474 putative active site [active] 443906007475 catalytic site [active] 443906007476 Diadenosine hexaphosphate (Ap6A) hydrolase is a member of the Nudix hydrolase superfamily. Ap6A hydrolase specifically hydrolyzes diadenosine polyphosphates, but not ATP or diadenosine triphosphate, and it generates ATP as the product. Ap6A, the most...; Region: Ap6A_hydrolase; cd03673 443906007477 active site 443906007478 Ap6A binding site [chemical binding]; other site 443906007479 nudix motif; other site 443906007480 metal binding site [ion binding]; metal-binding site 443906007481 Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067 443906007482 catalytic core [active] 443906007483 PBP superfamily domain; Region: PBP_like_2; cl17296 443906007484 phosphate transporter permease subunit PstC; Provisional; Region: pstC; PRK11275 443906007485 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 443906007486 dimer interface [polypeptide binding]; other site 443906007487 conserved gate region; other site 443906007488 putative PBP binding loops; other site 443906007489 ABC-ATPase subunit interface; other site 443906007490 phosphate ABC transporter, permease protein PstA; Region: 3a0107s02c; TIGR00974 443906007491 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 443906007492 dimer interface [polypeptide binding]; other site 443906007493 conserved gate region; other site 443906007494 putative PBP binding loops; other site 443906007495 ABC-ATPase subunit interface; other site 443906007496 phosphate transporter ATP-binding protein; Provisional; Region: PRK14241 443906007497 ATP-binding cassette domain of the phosphate transport system; Region: ABC_PstB_phosphate_transporter; cd03260 443906007498 Walker A/P-loop; other site 443906007499 ATP binding site [chemical binding]; other site 443906007500 Q-loop/lid; other site 443906007501 ABC transporter signature motif; other site 443906007502 Walker B; other site 443906007503 D-loop; other site 443906007504 H-loop/switch region; other site 443906007505 Anti-sigma-K factor rskA; Region: RskA; pfam10099 443906007506 RNA polymerase sigma factor SigK; Reviewed; Region: PRK09646 443906007507 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 443906007508 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 443906007509 DNA binding residues [nucleotide binding] 443906007510 Acyltransferase family; Region: Acyl_transf_3; pfam01757 443906007511 Predicted membrane protein [Function unknown]; Region: COG4763 443906007512 GDSL-like Lipase/Acylhydrolase family; Region: Lipase_GDSL_2; pfam13472 443906007513 Aldose 1-epimerase, similar to Escherichia coli YihR; Region: Aldose_epim_Ec_YihR; cd09022 443906007514 active site 443906007515 catalytic residues [active] 443906007516 Transcriptional regulators of sugar metabolism [Transcription / Carbohydrate transport and metabolism]; Region: GlpR; COG1349 443906007517 DeoR-like helix-turn-helix domain; Region: HTH_DeoR; cl17531 443906007518 DeoR C terminal sensor domain; Region: DeoRC; pfam00455 443906007519 HIT family: HIT (Histidine triad) proteins, named for a motif related to the sequence HxHxH/Qxx (x, a hydrophobic amino acid), are a superfamily of nucleotide hydrolases and transferases, which act on the alpha-phosphate of ribonucleotides. On the basis...; Region: HIT_like; cl00228 443906007520 Galactose-1-phosphate uridylyltransferase [Energy production and conversion]; Region: GalT; COG1085 443906007521 nucleotide binding site/active site [active] 443906007522 HIT family signature motif; other site 443906007523 catalytic residue [active] 443906007524 Galactokinase [Carbohydrate transport and metabolism]; Region: GalK; COG0153 443906007525 Galactokinase galactose-binding signature; Region: GalKase_gal_bdg; pfam10509 443906007526 GHMP kinases C terminal; Region: GHMP_kinases_C; pfam08544 443906007527 Carbonic anhydrases/acetyltransferases, isoleucine patch superfamily [General function prediction only]; Region: PaaY; COG0663 443906007528 Gamma carbonic anhydrase-like: This family is composed of gamma carbonic anhydrase (CA), Ferripyochelin Binding Protein (FBP), E. coli paaY protein, and similar proteins. CAs are zinc-containing enzymes that catalyze the reversible hydration of carbon...; Region: LbH_gamma_CA_like; cd04645 443906007529 trimer interface [polypeptide binding]; other site 443906007530 putative metal binding site [ion binding]; other site 443906007531 bifunctional 5,10-methylene-tetrahydrofolate dehydrogenase/ 5,10-methylene-tetrahydrofolate cyclohydrolase; Provisional; Region: PRK14193 443906007532 Tetrahydrofolate dehydrogenase/cyclohydrolase, catalytic domain; Region: THF_DHG_CYH; pfam00763 443906007533 NADP binding domain of methylene-tetrahydrofolate dehydrogenase/cyclohydrolase; Region: NAD_bind_m-THF_DH_Cyclohyd; cd01080 443906007534 homodimer interface [polypeptide binding]; other site 443906007535 NADP binding site [chemical binding]; other site 443906007536 substrate binding site [chemical binding]; other site 443906007537 serine hydroxymethyltransferase; Reviewed; Region: glyA; PRK00011 443906007538 Serine-glycine hydroxymethyltransferase (SHMT). This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). SHMT carries out interconversion of serine and glycine; it catalyzes the transfer of hydroxymethyl...; Region: SHMT; cd00378 443906007539 dimer interface [polypeptide binding]; other site 443906007540 active site 443906007541 glycine-pyridoxal phosphate binding site [chemical binding]; other site 443906007542 folate binding site [chemical binding]; other site 443906007543 Alpha amylase catalytic domain family; Region: AmyAc_family; cl07893 443906007544 Alpha amylase catalytic domain family; Region: AmyAc_family; cl07893 443906007545 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 443906007546 aminoethylphosphonate catabolism associated LysR family transcriptional regulator; Region: phn_lysR; TIGR03339 443906007547 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 443906007548 dimerization interface [polypeptide binding]; other site 443906007549 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 443906007550 H+ Antiporter protein; Region: 2A0121; TIGR00900 443906007551 putative substrate translocation pore; other site 443906007552 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 443906007553 Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248 443906007554 active site 443906007555 catalytic tetrad [active] 443906007556 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 443906007557 putative DNA binding site [nucleotide binding]; other site 443906007558 putative Zn2+ binding site [ion binding]; other site 443906007559 Helix-turn-helix diphteria tox regulatory element; Region: HTH_DTXR; smart00529 443906007560 Iron dependent repressor, metal binding and dimerisation domain; Region: Fe_dep_repr_C; pfam02742 443906007561 FeoA domain; Region: FeoA; pfam04023 443906007562 Mn2+ and Fe2+ transporters of the NRAMP family [Inorganic ion transport and metabolism]; Region: MntH; cl15845 443906007563 Natural resistance-associated macrophage protein; Region: Nramp; pfam01566 443906007564 HAD-superfamily hydrolase, subfamily IIB; Region: HAD-SF-IIB; TIGR01484 443906007565 Arabinose efflux permease [Carbohydrate transport and metabolism]; Region: AraJ; COG2814 443906007566 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 443906007567 formyltetrahydrofolate deformylase; Reviewed; Region: purU; PRK06027 443906007568 N-terminal ACT domain of formyltetrahydrofolate deformylase (F4HF-DF; formyltetrahydrofolate hydrolase); Region: ACT_F4HF-DF; cd04875 443906007569 Formyltetrahydrofolate deformylase (Formyl-FH4 hydrolase), C-terminal hydrolase domain; Region: FMT_core_Formyl-FH4-Hydrolase_C; cd08648 443906007570 putative active site [active] 443906007571 putative substrate binding site [chemical binding]; other site 443906007572 putative cosubstrate binding site; other site 443906007573 catalytic site [active] 443906007574 ABC-2 type transporter; Region: ABC2_membrane; cl17235 443906007575 ABC-type multidrug transport system, permease component [Defense mechanisms]; Region: COG0842 443906007576 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 443906007577 daunorubicin resistance ABC transporter ATP-binding subunit; Region: drrA; TIGR01188 443906007578 Walker A/P-loop; other site 443906007579 ATP binding site [chemical binding]; other site 443906007580 Q-loop/lid; other site 443906007581 ABC transporter signature motif; other site 443906007582 Walker B; other site 443906007583 D-loop; other site 443906007584 H-loop/switch region; other site 443906007585 Peptidase inhibitor I9; Region: Inhibitor_I9; pfam05922 443906007586 Peptidase S8 family domain, uncharacterized subfamily 3; Region: Peptidases_S8_3; cd04852 443906007587 active site 443906007588 catalytic triad [active] 443906007589 PA_subtilisin_like: Protease-associated domain containing subtilisin-like proteases. This group contains various PA domain-containing subtilisin-like proteases including melon cucumisin, Arabidopsis thaliana Ara12, a nodule specific serine protease from...; Region: PA_subtilisin_like; cd02120 443906007590 Peptidase S8 family domain in Vpr-like proteins; Region: Peptidases_S8_subtilisin_Vpr-like; cd07474 443906007591 Peptidase inhibitor I9; Region: Inhibitor_I9; pfam05922 443906007592 Peptidase domain in the S8 and S53 families; Region: Peptidases_S8_S53; cl10459 443906007593 active site 443906007594 catalytic residues [active] 443906007595 PA_subtilisin_like: Protease-associated domain containing subtilisin-like proteases. This group contains various PA domain-containing subtilisin-like proteases including melon cucumisin, Arabidopsis thaliana Ara12, a nodule specific serine protease from...; Region: PA_subtilisin_like; cd02120 443906007596 PA/protease or protease-like domain interface [polypeptide binding]; other site 443906007597 Peptidase domain in the S8 and S53 families; Region: Peptidases_S8_S53; cl10459 443906007598 catalytic residues [active] 443906007599 isocitrate dehydrogenase; Validated; Region: PRK08299 443906007600 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 443906007601 Coenzyme A binding pocket [chemical binding]; other site 443906007602 The DNA repair protein O6-alkylguanine-DNA alkyltransferase (ATase; also known as AGT, AGAT and MGMT) reverses O6-alkylation DNA damage by transferring O6-alkyl adducts to an active site cysteine irreversibly, without inducing DNA strand breaks. ATases...; Region: ATase; cd06445 443906007603 DNA binding site [nucleotide binding] 443906007604 active site 443906007605 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 443906007606 ABC-type transport system involved in Fe-S cluster assembly, permease and ATPase components [Posttranslational modification, protein turnover, chaperones]; Region: ATM1; COG5265 443906007607 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 443906007608 Walker A/P-loop; other site 443906007609 ATP binding site [chemical binding]; other site 443906007610 Q-loop/lid; other site 443906007611 ABC transporter signature motif; other site 443906007612 Walker B; other site 443906007613 D-loop; other site 443906007614 H-loop/switch region; other site 443906007615 ABC transporter, permease/ATP-binding protein; Region: MsbA_rel; TIGR02204 443906007616 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 443906007617 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 443906007618 Walker A/P-loop; other site 443906007619 ATP binding site [chemical binding]; other site 443906007620 Q-loop/lid; other site 443906007621 ABC transporter signature motif; other site 443906007622 Walker B; other site 443906007623 D-loop; other site 443906007624 H-loop/switch region; other site 443906007625 N-Dimethylarginine dimethylaminohydrolase [Amino acid transport and metabolism]; Region: COG1834 443906007626 Amidinotransferase; Region: Amidinotransf; cl12043 443906007627 bifunctional phosphoribosylaminoimidazolecarboxamide formyltransferase/IMP cyclohydrolase; Provisional; Region: purH; PRK00881 443906007628 Inosine monophosphate cyclohydrolase domain. This is the N-terminal domain in the purine biosynthesis pathway protein ATIC (purH). The bifunctional ATIC protein contains a C-terminal ATIC formylase domain that formylates...; Region: IMPCH; cd01421 443906007629 purine monophosphate binding site [chemical binding]; other site 443906007630 dimer interface [polypeptide binding]; other site 443906007631 putative catalytic residues [active] 443906007632 AICARFT/IMPCHase bienzyme; Region: AICARFT_IMPCHas; smart00798 443906007633 AICARFT/IMPCHase bienzyme; Region: AICARFT_IMPCHas; cl03362 443906007634 phosphoribosylglycinamide formyltransferase; Reviewed; Region: purN; PRK05647 443906007635 Phosphoribosylglycinamide formyltransferase (GAR transformylase, GART); Region: FMT_core_GART; cd08645 443906007636 active site 443906007637 substrate binding site [chemical binding]; other site 443906007638 cosubstrate binding site; other site 443906007639 catalytic site [active] 443906007640 succinyl-CoA synthetase subunit alpha; Validated; Region: PRK05678 443906007641 CoA binding domain; Region: CoA_binding; smart00881 443906007642 CoA-ligase; Region: Ligase_CoA; pfam00549 443906007643 succinyl-CoA synthetase subunit beta; Provisional; Region: sucC; PRK00696 443906007644 ATP-grasp domain; Region: ATP-grasp_2; pfam08442 443906007645 CoA-ligase; Region: Ligase_CoA; pfam00549 443906007646 Uncharacterized protein conserved in bacteria (DUF2236); Region: DUF2236; pfam09995 443906007647 ATP-dependent DNA helicase PcrA; Region: pcrA; TIGR01073 443906007648 Part of AAA domain; Region: AAA_19; pfam13245 443906007649 Family description; Region: UvrD_C_2; pfam13538 443906007650 Glycerophosphoryl diester phosphodiesterase [Energy production and conversion]; Region: UgpQ; COG0584 443906007651 Catalytic domain of phosphoinositide-specific phospholipase C-like phosphodiesterases superfamily; Region: PI-PLCc_GDPD_SF; cl14615 443906007652 active site 443906007653 catalytic site [active] 443906007654 Bax inhibitor 1 like; Region: BaxI_1; cl17691 443906007655 GMP synthase; Reviewed; Region: guaA; PRK00074 443906007656 Type 1 glutamine amidotransferase (GATase1) domain found in GMP synthetase; Region: GATase1_GMP_Synthase; cd01742 443906007657 AMP/PPi binding site [chemical binding]; other site 443906007658 candidate oxyanion hole; other site 443906007659 catalytic triad [active] 443906007660 potential glutamine specificity residues [chemical binding]; other site 443906007661 The C-terminal domain of GMP synthetase. It contains two subdomains; the ATP pyrophosphatase domain which closes to the N-termial and the dimerization domain at C-terminal end. The ATP-PPase is a twisted, five-stranded parallel beta-sheet sandwiched...; Region: GMP_synthase_C; cd01997 443906007662 ATP Binding subdomain [chemical binding]; other site 443906007663 Ligand Binding sites [chemical binding]; other site 443906007664 Dimerization subdomain; other site 443906007665 Domain of unknown function (DUF3817); Region: DUF3817; pfam12823 443906007666 SURF1 superfamily. Surf1/Shy1 has been implicated in the posttranslational steps of the biogenesis of the mitochondrially-encoded Cox1 subunit of cytochrome c oxidase (complex IV). Cytochrome c oxidase (complex IV), the terminal electron-transferring...; Region: SURF1; cl01321 443906007667 Sodium/hydrogen exchanger family; Region: Na_H_Exchanger; pfam00999 443906007668 Kef-type K+ transport systems, membrane components [Inorganic ion transport and metabolism]; Region: KefB; COG0475 443906007669 Putative regulatory, ligand-binding protein related to C-terminal domains of K+ channels [Inorganic ion transport and metabolism]; Region: COG0490 443906007670 TrkA-C domain; Region: TrkA_C; pfam02080 443906007671 inosine 5-monophosphate dehydrogenase; Validated; Region: PRK08649 443906007672 IMPDH: The catalytic domain of the inosine monophosphate dehydrogenase. IMPDH catalyzes the NAD-dependent oxidation of inosine 5'-monophosphate (IMP) to xanthosine 5' monophosphate (XMP). It is a rate-limiting step in the de novo synthesis of...; Region: IMPDH; cd00381 443906007673 active site 443906007674 inosine 5'-monophosphate dehydrogenase; Reviewed; Region: PRK05567 443906007675 TIM barrel proteins share a structurally conserved phosphate binding motif and in general share an eight beta/alpha closed barrel structure. Specific for this family is the conserved phosphate binding site at the edges of strands 7 and 8. The phosphate...; Region: TIM_phosphate_binding; cl17186 443906007676 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains in the inosine 5' monophosphate dehydrogenase (IMPDH) protein. IMPDH is an essential enzyme that catalyzes the first step unique to GTP synthesis, playing a...; Region: CBS_pair_IMPDH; cd04601 443906007677 IMPDH: The catalytic domain of the inosine monophosphate dehydrogenase. IMPDH catalyzes the NAD-dependent oxidation of inosine 5'-monophosphate (IMP) to xanthosine 5' monophosphate (XMP). It is a rate-limiting step in the de novo synthesis of...; Region: IMPDH; cd00381 443906007678 active site 443906007679 Transmembrane subunit (TM) of Escherichia coli LivH and related proteins. LivH is one of two TMs of the E. coli LIV-1/LS transporter, a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of...; Region: TM_PBP1_LivH_like; cd06582 443906007680 Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653 443906007681 TM-ABC transporter signature motif; other site 443906007682 ABC-type branched-chain amino acid transport system, permease component [Amino acid transport and metabolism]; Region: LivM; COG4177 443906007683 Transmembrane subunit (TM) of Escherichia coli LivM and related proteins. LivM is one of two TMs of the E. coli LIV-1/LS transporter, a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of...; Region: TM_PBP1_LivM_like; cd06581 443906007684 TM-ABC transporter signature motif; other site 443906007685 ABC-type branched-chain amino acid transport systems, ATPase component [Amino acid transport and metabolism]; Region: LivG; COG0411 443906007686 ATP-binding cassette component of branched chain amino acids transport system; Region: ABC_Mj1267_LivG_branched; cd03219 443906007687 Walker A/P-loop; other site 443906007688 ATP binding site [chemical binding]; other site 443906007689 Q-loop/lid; other site 443906007690 ABC transporter signature motif; other site 443906007691 Walker B; other site 443906007692 D-loop; other site 443906007693 H-loop/switch region; other site 443906007694 ABC-type branched-chain amino acid transport systems, ATPase component [Amino acid transport and metabolism]; Region: LivF; COG0410 443906007695 ATP-binding cassette domain of branched-chain amino acid transporter; Region: ABC_TM1139_LivF_branched; cd03224 443906007696 Walker A/P-loop; other site 443906007697 ATP binding site [chemical binding]; other site 443906007698 Q-loop/lid; other site 443906007699 ABC transporter signature motif; other site 443906007700 Walker B; other site 443906007701 D-loop; other site 443906007702 H-loop/switch region; other site 443906007703 ABC-type branched-chain amino acid transport systems, periplasmic component [Amino acid transport and metabolism]; Region: LivK; COG0683 443906007704 Type 1 periplasmic binding fold superfamily; Region: Periplasmic_Binding_Protein_Type_1; cl10011 443906007705 Predicted permeases [General function prediction only]; Region: RarD; COG2962 443906007706 Chaperonin 10 Kd subunit (cpn10 or GroES); Cpn10 cooperates with chaperonin 60 (cpn60 or GroEL), an ATPase, to assist the folding and assembly of proteins and is found in eubacterial cytosol, as well as in the matrix of mitochondria and chloroplasts. It...; Region: cpn10; cd00320 443906007707 oligomerisation interface [polypeptide binding]; other site 443906007708 mobile loop; other site 443906007709 roof hairpin; other site 443906007710 Protein of unknown function (DUF2852); Region: DUF2852; pfam11014 443906007711 ribosomal-protein-alanine acetyltransferase; Region: rimI; TIGR01575 443906007712 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 443906007713 Coenzyme A binding pocket [chemical binding]; other site 443906007714 UGMP family protein; Validated; Region: PRK09604 443906007715 Inactive homolog of metal-dependent proteases, putative molecular chaperone [Posttranslational modification, protein turnover, chaperones]; Region: COG1214; cl17884 443906007716 tRNA threonylcarbamoyl adenosine modification protein YeaZ; Region: T6A_YeaZ; TIGR03725 443906007717 Glycoprotease family; Region: Peptidase_M22; pfam00814 443906007718 Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzyme Alanine Racemase; Region: PLPDE_III_AR; cd00430 443906007719 alanine racemase; Reviewed; Region: alr; PRK00053 443906007720 active site 443906007721 pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site 443906007722 dimer interface [polypeptide binding]; other site 443906007723 substrate binding site [chemical binding]; other site 443906007724 catalytic residues [active] 443906007725 Uncharacterized P-loop hydrolase UPF0079; Region: UPF0079; pfam02367 443906007726 alanine racemase; Reviewed; Region: alr; PRK00053 443906007727 Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzyme Alanine Racemase; Region: PLPDE_III_AR; cd00430 443906007728 active site 443906007729 pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site 443906007730 dimer interface [polypeptide binding]; other site 443906007731 substrate binding site [chemical binding]; other site 443906007732 catalytic residues [active] 443906007733 4'-phosphopantetheinyl transferase; Provisional; Region: acpS; PRK00070 443906007734 glucosamine--fructose-6-phosphate aminotransferase; Reviewed; Region: PRK00331 443906007735 Glutamine amidotransferases class-II (Gn-AT)_GFAT-type. This domain is found at the N-terminus of glucosamine-6P synthase (GlmS, or GFAT in humans). The glutaminase domain catalyzes amide nitrogen transfer from glutamine to the appropriate substrate. In...; Region: GFAT; cd00714 443906007736 glutaminase active site [active] 443906007737 SIS (Sugar ISomerase) domain repeat 1 found in Glucosamine 6-phosphate synthase (GlmS) and Glucosamine-6-phosphate deaminase (GlmD). The SIS domain is found in many phosphosugar isomerases and phosphosugar binding proteins. GlmS contains a N-terminal...; Region: SIS_GlmS_GlmD_1; cd05008 443906007738 dimer interface [polypeptide binding]; other site 443906007739 active site 443906007740 SIS (Sugar ISomerase) domain repeat 2 found in Glucosamine 6-phosphate synthase (GlmS) and Glucosamine-6-phosphate deaminase (GlmD). The SIS domain is found in many phosphosugar isomerases and phosphosugar binding proteins. GlmS contains a N-terminal...; Region: SIS_GlmS_GlmD_2; cd05009 443906007741 dimer interface [polypeptide binding]; other site 443906007742 active site 443906007743 pantothenate kinase; Provisional; Region: PRK05439 443906007744 Pantothenate kinase (PanK) catalyzes the phosphorylation of pantothenic acid to form 4'-phosphopantothenic, which is the first of five steps in coenzyme A (CoA) biosynthetic pathway. The reaction carried out by this enzyme is a key regulatory point...; Region: PanK; cd02025 443906007745 ATP-binding site [chemical binding]; other site 443906007746 CoA-binding site [chemical binding]; other site 443906007747 Mg2+-binding site [ion binding]; other site 443906007748 phosphoglucosamine mutase; Provisional; Region: glmM; PRK14318 443906007749 GlmM is a bacterial phosphoglucosamine mutase (PNGM) that belongs to the alpha-D-phosphohexomutase superfamily. It is required for the interconversion of glucosamine-6-phosphate and glucosamine-1-phosphate in the biosynthetic pathway of...; Region: GlmM; cd05802 443906007750 active site 443906007751 substrate binding site [chemical binding]; other site 443906007752 metal binding site [ion binding]; metal-binding site 443906007753 30S ribosomal protein S9; Reviewed; Region: rpsI; PRK00132 443906007754 Ribosomal protein L13. Protein L13, a large ribosomal subunit protein, is one of five proteins required for an early folding intermediate of 23S rRNA in the assembly of the large subunit. L13 is situated on the bottom of the large subunit, near the...; Region: Ribosomal_L13; cd00392 443906007755 23S rRNA interface [nucleotide binding]; other site 443906007756 L3 interface [polypeptide binding]; other site 443906007757 tRNA pseudouridine synthase A; Validated; Region: truA; PRK00021 443906007758 Eukaryotic and bacterial pseudouridine synthases similar to E. coli TruA; Region: PseudoU_synth_EcTruA; cd02570 443906007759 dimerization interface 3.5A [polypeptide binding]; other site 443906007760 active site 443906007761 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 443906007762 Coenzyme A binding pocket [chemical binding]; other site 443906007763 Acetyltransferase (GNAT) domain; Region: Acetyltransf_10; pfam13673 443906007764 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 443906007765 Coenzyme A binding pocket [chemical binding]; other site 443906007766 50S ribosomal protein L17; Validated; Region: rplQ; PRK05591 443906007767 DNA-directed RNA polymerase subunit alpha; Provisional; Region: PRK05182 443906007768 N-terminal domain of the Alpha subunit of Bacterial RNA polymerase; Region: RNAP_alpha_NTD; cd06928 443906007769 alphaNTD homodimer interface [polypeptide binding]; other site 443906007770 alphaNTD - beta interaction site [polypeptide binding]; other site 443906007771 alphaNTD - beta' interaction site [polypeptide binding]; other site 443906007772 Bacterial RNA polymerase, alpha chain C terminal domain; Region: RNA_pol_A_CTD; pfam03118 443906007773 30S ribosomal protein S11; Validated; Region: PRK05309 443906007774 30S ribosomal protein S13; Validated; Region: rpsM; PRK05179 443906007775 30S ribosomal protein S13; Region: bact_S13; TIGR03631 443906007776 50S ribosomal protein L36; Reviewed; Region: rpmJ; PRK00465 443906007777 S1_IF1: Translation Initiation Factor IF1, S1-like RNA-binding domain. IF1 contains an S1-like RNA-binding domain, which is found in a wide variety of RNA-associated proteins. Translation initiation includes a number of interrelated steps preceding the...; Region: S1_IF1; cd04451 443906007778 rRNA binding site [nucleotide binding]; other site 443906007779 predicted 30S ribosome binding site; other site 443906007780 mannitol-1-phosphate 5-dehydrogenase; Provisional; Region: PRK02318 443906007781 Mannitol dehydrogenase Rossmann domain; Region: Mannitol_dh; pfam01232 443906007782 Mannitol dehydrogenase C-terminal domain; Region: Mannitol_dh_C; pfam08125 443906007783 PTS_IIA, PTS system, fructose/mannitol specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_fru; cd00211 443906007784 active site 443906007785 phosphorylation site [posttranslational modification] 443906007786 Phosphotransferase system, mannitol-specific IIBC component [Carbohydrate transport and metabolism]; Region: MtlA; COG2213 443906007787 PTS system, mannitol-specific IIC component; Region: mtlA; TIGR00851 443906007788 PTS_IIB_mannitol: subunit IIB of enzyme II (EII) of the mannitol-specific phosphoenolpyruvate:carbohydrate phosphotransferase system (PTS). In this system, EII is a mannitol-specific permease with two cytoplasmic domains (IIA and IIB) and a transmembrane...; Region: PTS_IIB_mannitol; cd05567 443906007789 active site 443906007790 P-loop; other site 443906007791 phosphorylation site [posttranslational modification] 443906007792 Phosphoenolpyruvate-protein kinase (PTS system EI component in bacteria) [Carbohydrate transport and metabolism]; Region: PtsA; COG1080 443906007793 PEP-utilising enzyme, N-terminal; Region: PEP-utilisers_N; pfam05524 443906007794 PEP-utilising enzyme, mobile domain; Region: PEP-utilizers; pfam00391 443906007795 PEP-utilising enzyme, TIM barrel domain; Region: PEP-utilizers_C; pfam02896 443906007796 Histidine-containing phosphocarrier protein (HPr)-like proteins. HPr is a central component of the bacterial phosphoenolpyruvate sugar phosphotransferase system (PTS). The PTS catalyses the phosphorylation of sugar substrates during their translocation...; Region: PTS-HPr_like; cd00367 443906007797 dimerization domain swap beta strand [polypeptide binding]; other site 443906007798 regulatory protein interface [polypeptide binding]; other site 443906007799 active site 443906007800 regulatory phosphorylation site [posttranslational modification]; other site 443906007801 PTS_IIB: subunit IIB of enzyme II (EII) is the central energy-coupling domain of the phosphoenolpyruvate:carbohydrate phosphotransferase system (PTS). In the multienzyme PTS complex, EII is a carbohydrate-specific permease consisting of two cytoplasmic...; Region: PTS_IIB; cl10014 443906007802 active site 443906007803 P-loop; other site 443906007804 phosphorylation site [posttranslational modification] 443906007805 HTH domain; Region: HTH_11; cl17392 443906007806 PRD domain; Region: PRD; pfam00874 443906007807 PTS_IIB: subunit IIB of enzyme II (EII) is the central energy-coupling domain of the phosphoenolpyruvate:carbohydrate phosphotransferase system (PTS). In the multienzyme PTS complex, EII is a carbohydrate-specific permease consisting of two cytoplasmic...; Region: PTS_IIB; cl10014 443906007808 active site 443906007809 P-loop; other site 443906007810 phosphorylation site [posttranslational modification] 443906007811 PTS_IIA, PTS system, fructose/mannitol specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_fru; cd00211 443906007812 active site 443906007813 phosphorylation site [posttranslational modification] 443906007814 Methionine Aminopeptidase 1. E.C. 3.4.11.18. Also known as methionyl aminopeptidase and Peptidase M. Catalyzes release of N-terminal amino acids, preferentially methionine, from peptides and arylamides; Region: MetAP1; cd01086 443906007815 active site 443906007816 adenylate kinase; Reviewed; Region: adk; PRK00279 443906007817 Adenylate kinase (ADK) catalyzes the reversible phosphoryl transfer from adenosine triphosphates (ATP) to adenosine monophosphates (AMP) and to yield adenosine diphosphates (ADP). This enzyme is required for the biosynthesis of ADP and is essential for...; Region: ADK; cd01428 443906007818 AMP-binding site [chemical binding]; other site 443906007819 ATP-AMP (Ap5A)-binding site [chemical binding]; other site 443906007820 preprotein translocase subunit SecY; Reviewed; Region: secY; PRK09204 443906007821 SecY translocase; Region: SecY; pfam00344 443906007822 50S ribosomal protein L15; Reviewed; Region: rplO; PRK05592 443906007823 Ribosomal protein L30, which is found in eukaryotes and prokaryotes but not in archaea, is one of the smallest ribosomal proteins with a molecular mass of about 7kDa. L30 binds the 23SrRNA as well as the 5S rRNA and is one of five ribosomal proteins that...; Region: Ribosomal_L30; cd01658 443906007824 23S rRNA binding site [nucleotide binding]; other site 443906007825 30S ribosomal protein S5; Validated; Region: rpsE; PRK00550 443906007826 Ribosomal protein S5, N-terminal domain; Region: Ribosomal_S5; pfam00333 443906007827 Ribosomal protein S5, C-terminal domain; Region: Ribosomal_S5_C; pfam03719 443906007828 Ribosomal L18/L5e: L18 (L5e) is a ribosomal protein found in the central protuberance (CP) of the large subunit. L18 binds 5S rRNA and induces a conformational change that stimulates the binding of L5 to 5S rRNA. Association of 5S rRNA with 23S rRNA...; Region: Ribosomal_L18_L5e; cd00432 443906007829 5S rRNA interface [nucleotide binding]; other site 443906007830 L27 interface [polypeptide binding]; other site 443906007831 23S rRNA interface [nucleotide binding]; other site 443906007832 L5 interface [polypeptide binding]; other site 443906007833 50S ribosomal protein L6; Validated; Region: rplF; PRK05498 443906007834 Ribosomal protein L6; Region: Ribosomal_L6; pfam00347 443906007835 Ribosomal protein L6; Region: Ribosomal_L6; pfam00347 443906007836 30S ribosomal protein S8; Validated; Region: rpsH; PRK00136 443906007837 50S ribosomal protein L5; Validated; Region: rplE; PRK00010 443906007838 Ribosomal protein L5; Region: Ribosomal_L5; pfam00281 443906007839 ribosomal L5P family C-terminus; Region: Ribosomal_L5_C; pfam00673 443906007840 50S ribosomal protein L24; Reviewed; Region: rplX; PRK00004 443906007841 KOW motif of Ribosomal Protein L26; Region: KOW_RPL26; cd06089 443906007842 RNA binding site [nucleotide binding]; other site 443906007843 50S ribosomal protein L14; Validated; Region: rplN; PRK05483 443906007844 30S ribosomal protein S17; Reviewed; Region: rpsQ; PRK05610 443906007845 Ribosomal L29 protein/HIP. L29 is a protein of the large ribosomal Subunit. A homolog, called heparin/heparan sulfate interacting protein (HIP), has also been identified in mammals. L29 is located on the surface of the large ribosomal subunit, where it...; Region: Ribosomal_L29_HIP; cd00427 443906007846 L23 interface [polypeptide binding]; other site 443906007847 signal recognition particle (SRP54) interaction site; other site 443906007848 trigger factor interaction site; other site 443906007849 23S rRNA interface [nucleotide binding]; other site 443906007850 Ribosomal_L16_L10e: L16 is an essential protein in the large ribosomal subunit of bacteria, mitochondria, and chloroplasts. Large subunits that lack L16 are defective in peptidyl transferase activity, peptidyl-tRNA hydrolysis activity, association with...; Region: Ribosomal_L16_L10e; cd01433 443906007851 23S rRNA interface [nucleotide binding]; other site 443906007852 5S rRNA interface [nucleotide binding]; other site 443906007853 putative antibiotic binding site [chemical binding]; other site 443906007854 L25 interface [polypeptide binding]; other site 443906007855 L27 interface [polypeptide binding]; other site 443906007856 30S ribosomal protein S3; Reviewed; Region: rpsC; PRK00310 443906007857 K homology RNA-binding (KH) domain of the prokaryotic 30S small ribosomal subunit protein S3. S3 is part of the head region of the 30S ribosomal subunit and is believed to interact with mRNA as it threads its way from the latch into the channel. The KH...; Region: 30S_S3_KH; cd02412 443906007858 G-X-X-G motif; other site 443906007859 Ribosomal protein S3, C-terminal domain; Region: Ribosomal_S3_C; pfam00189 443906007860 Ribosomal protein L22/L17e. L22 (L17 in eukaryotes) is a core protein of the large ribosomal subunit. It is the only ribosomal protein that interacts with all six domains of 23S rRNA, and is one of the proteins important for directing the proper...; Region: Ribosomal_L22; cd00336 443906007861 protein-rRNA interface [nucleotide binding]; other site 443906007862 putative translocon binding site; other site 443906007863 30S ribosomal protein S19; Reviewed; Region: rpsS; PRK00357 443906007864 50S ribosomal protein L2; Validated; Region: rplB; PRK09374 443906007865 Ribosomal Proteins L2, RNA binding domain; Region: Ribosomal_L2; pfam00181 443906007866 Ribosomal Proteins L2, C-terminal domain; Region: Ribosomal_L2_C; pfam03947 443906007867 50S ribosomal protein L23; Reviewed; Region: rplW; PRK05738 443906007868 50S ribosomal protein L4; Provisional; Region: rplD; PRK05319 443906007869 50S ribosomal protein L3; Validated; Region: rplC; PRK00001 443906007870 30S ribosomal protein S10; Reviewed; Region: rpsJ; PRK00596 443906007871 Topoisomerase IB [DNA replication, recombination, and repair]; Region: COG3569 443906007872 Eukaryotic DNA topoisomerase I, catalytic core; Region: Topoisom_I; pfam01028 443906007873 active site 443906007874 DNA binding site [nucleotide binding] 443906007875 Int/Topo IB signature motif; other site 443906007876 elongation factor Tu; Reviewed; Region: PRK00049 443906007877 Elongation Factor Tu (EF-Tu) GTP-binding proteins; Region: EF_Tu; cd01884 443906007878 G1 box; other site 443906007879 GEF interaction site [polypeptide binding]; other site 443906007880 GTP/Mg2+ binding site [chemical binding]; other site 443906007881 Switch I region; other site 443906007882 G2 box; other site 443906007883 G3 box; other site 443906007884 Switch II region; other site 443906007885 G4 box; other site 443906007886 G5 box; other site 443906007887 EFTU_II: Elongation factor Tu domain II. Elongation factors Tu (EF-Tu) are three-domain GTPases with an essential function in the elongation phase of mRNA translation. The GTPase center of EF-Tu is in the N-terminal domain (domain I), also known as the...; Region: EFTU_II; cd03697 443906007888 Domain III of elongation factor (EF) Tu. Ef-Tu consists of three structural domains, designated I, II and III. Domain III adopts a beta barrel structure. Domain III is involved in binding to both charged tRNA and binding to elongation factor Ts (EF-Ts); Region: EFTU_III; cd03707 443906007889 Antibiotic Binding Site [chemical binding]; other site 443906007890 elongation factor G; Reviewed; Region: PRK00007 443906007891 Elongation factor G (EF-G) family involved in both the elongation and ribosome recycling phases of protein synthesis; Region: EF-G; cd01886 443906007892 G1 box; other site 443906007893 putative GEF interaction site [polypeptide binding]; other site 443906007894 GTP/Mg2+ binding site [chemical binding]; other site 443906007895 Switch I region; other site 443906007896 G2 box; other site 443906007897 G3 box; other site 443906007898 Switch II region; other site 443906007899 G4 box; other site 443906007900 G5 box; other site 443906007901 EFG_mtEFG_II: this subfamily represents the domain II of elongation factor G (EF-G) in bacteria and, the C-terminus of mitochondrial Elongation factor G1 (mtEFG1) and G2 (mtEFG2)_like proteins found in eukaryotes. During the process of peptide synthesis...; Region: EFG_mtEFG_II; cd04088 443906007902 EFG_mtEFG1_IV: domains similar to domain IV of the bacterial translational elongation factor (EF) EF-G. Included in this group is a domain of mitochondrial Elongation factor G1 (mtEFG1) proteins homologous to domain IV of EF-G. Eukaryotic cells harbor 2...; Region: EFG_mtEFG1_IV; cd01434 443906007903 EFG_mtEFG_C: domains similar to the C-terminal domain of the bacterial translational elongation factor (EF) EF-G. Included in this group is the C-terminus of mitochondrial Elongation factor G1 (mtEFG1) and G2 (mtEFG2) proteins. Eukaryotic cells harbor 2...; Region: EFG_mtEFG_C; cd03713 443906007904 30S ribosomal protein S7; Validated; Region: PRK05302 443906007905 S12-like family, 30S ribosomal protein S12 subfamily; S12 is located at the interface of the large and small ribosomal subunits of prokaryotes, chloroplasts and mitochondria, where it plays an important role in both tRNA and ribosomal subunit...; Region: Ribosomal_S12; cd03368 443906007906 S17 interaction site [polypeptide binding]; other site 443906007907 S8 interaction site; other site 443906007908 16S rRNA interaction site [nucleotide binding]; other site 443906007909 streptomycin interaction site [chemical binding]; other site 443906007910 23S rRNA interaction site [nucleotide binding]; other site 443906007911 aminoacyl-tRNA interaction site (A-site) [nucleotide binding]; other site 443906007912 ABC-type polar amino acid transport system, ATPase component [Amino acid transport and metabolism]; Region: GlnQ; COG1126 443906007913 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 443906007914 Walker A/P-loop; other site 443906007915 ATP binding site [chemical binding]; other site 443906007916 Q-loop/lid; other site 443906007917 ABC transporter signature motif; other site 443906007918 Walker B; other site 443906007919 D-loop; other site 443906007920 H-loop/switch region; other site 443906007921 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 443906007922 ABC-type arginine transport system, permease component [Amino acid transport and metabolism]; Region: ArtQ; COG4215 443906007923 dimer interface [polypeptide binding]; other site 443906007924 conserved gate region; other site 443906007925 putative PBP binding loops; other site 443906007926 ABC-ATPase subunit interface; other site 443906007927 Bacterial extracellular solute-binding proteins, family 3; Region: SBP_bac_3; pfam00497 443906007928 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 443906007929 substrate binding pocket [chemical binding]; other site 443906007930 membrane-bound complex binding site; other site 443906007931 hinge residues; other site 443906007932 RNA polymerase Rpb1, domain 1; Region: RNA_pol_Rpb1_1; pfam04997 443906007933 DNA-directed RNA polymerase subunit beta'; Provisional; Region: PRK00566 443906007934 RNA polymerase I subunit A N-terminus; Region: RPOLA_N; smart00663 443906007935 RNA polymerase Rpb1, domain 3; Region: RNA_pol_Rpb1_3; pfam04983 443906007936 RNA polymerase Rpb1, domain 4; Region: RNA_pol_Rpb1_4; pfam05000 443906007937 Largest subunit (beta') of Bacterial DNA-dependent RNA polymerase (RNAP), C-terminal domain; Region: RNAP_beta'_C; cd02655 443906007938 Rpb1 (beta') - Rpb6 (omega) interaction site [polypeptide binding]; other site 443906007939 Rpb1 (beta') - Rpb2 (beta) interaction site [polypeptide binding]; other site 443906007940 G-loop; other site 443906007941 DNA binding site [nucleotide binding] 443906007942 DNA-directed RNA polymerase subunit beta; Reviewed; Region: rpoB; PRK00405 443906007943 RNA polymerase beta subunit. RNA polymerases catalyse the DNA dependent polymerization of RNA. Prokaryotes contain a single RNA polymerase compared to three in eukaryotes (not including mitochondrial. and chloroplast polymerases). Each RNA polymerase...; Region: RNA_pol_B_RPB2; cl17585 443906007944 RNA polymerase beta subunit. RNA polymerases catalyse the DNA dependent polymerization of RNA. Prokaryotes contain a single RNA polymerase compared to three in eukaryotes (not including mitochondrial. and chloroplast polymerases). Each RNA polymerase...; Region: RNA_pol_B_RPB2; cd00653 443906007945 RNA polymerase beta subunit. RNA polymerases catalyse the DNA dependent polymerization of RNA. Prokaryotes contain a single RNA polymerase compared to three in eukaryotes (not including mitochondrial. and chloroplast polymerases). Each RNA polymerase...; Region: RNA_pol_B_RPB2; cd00653 443906007946 RPB10 interaction site [polypeptide binding]; other site 443906007947 RPB1 interaction site [polypeptide binding]; other site 443906007948 RPB11 interaction site [polypeptide binding]; other site 443906007949 RPB3 interaction site [polypeptide binding]; other site 443906007950 RPB12 interaction site [polypeptide binding]; other site 443906007951 Zn-dependent hydrolases, including glyoxylases [General function prediction only]; Region: GloB; COG0491 443906007952 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl17173 443906007953 dehydrogenase, PQQ-dependent, s-GDH family; Region: non_repeat_PQQ; TIGR03606 443906007954 Glucose / Sorbosone dehydrogenase; Region: GSDH; pfam07995 443906007955 SprT-like family; Region: SprT-like; pfam10263 443906007956 SprT homologues; Region: SprT; cl01182 443906007957 Protein of unknown function (DUF1470); Region: DUF1470; pfam07336 443906007958 CGNR zinc finger; Region: zf-CGNR; pfam11706 443906007959 Domain of unknown function (DUF427); Region: DUF427; pfam04248 443906007960 EVE domain; Region: EVE; cl00728 443906007961 Protein of unknown function (DUF1684); Region: DUF1684; pfam07920 443906007962 helicase 45; Provisional; Region: PTZ00424 443906007963 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cl17251 443906007964 ATP binding site [chemical binding]; other site 443906007965 putative Mg++ binding site [ion binding]; other site 443906007966 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 443906007967 nucleotide binding region [chemical binding]; other site 443906007968 ATP-binding site [chemical binding]; other site 443906007969 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 443906007970 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 443906007971 Nudix hydrolase is a superfamily of enzymes found in all three kingdoms of life, and it catalyzes the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+...; Region: Nudix_Hydrolase; cl00447 443906007972 nudix motif; other site 443906007973 Predicted esterase [General function prediction only]; Region: COG0400 443906007974 putative hydrolase; Provisional; Region: PRK11460 443906007975 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 443906007976 putative ATP-dependent helicase Lhr; Provisional; Region: PRK09751 443906007977 ATP binding site [chemical binding]; other site 443906007978 putative Mg++ binding site [ion binding]; other site 443906007979 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 443906007980 nucleotide binding region [chemical binding]; other site 443906007981 ATP-binding site [chemical binding]; other site 443906007982 DEAD/H associated; Region: DEAD_assoc; pfam08494 443906007983 Formamidopyrimidine-DNA glycosylase [DNA replication, recombination, and repair]; Region: Nei; COG0266 443906007984 N-terminal domain of the actinomycetal Nei2 and related DNA glycosylases; Region: AcNei2_N; cd08971 443906007985 putative DNA binding site [nucleotide binding]; other site 443906007986 catalytic residue [active] 443906007987 putative H2TH interface [polypeptide binding]; other site 443906007988 putative catalytic residues [active] 443906007989 Formamidopyrimidine-DNA glycosylase H2TH domain; Region: H2TH; pfam06831 443906007990 Zinc finger found in FPG and IleRS; Region: zf-FPG_IleRS; pfam06827 443906007991 amino acid transporter; Region: 2A0306; TIGR00909 443906007992 C-terminus of AA_permease; Region: AA_permease_C; pfam13906 443906007993 RNA polymerase sigma-70 factor, sigma-B/F/G subfamily; Region: SigBFG; TIGR02980 443906007994 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 443906007995 Sigma-70 region 3; Region: Sigma70_r3; pfam04539 443906007996 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 443906007997 DNA binding residues [nucleotide binding] 443906007998 ANTAR domain; Region: ANTAR; pfam03861 443906007999 PspC domain; Region: PspC; pfam04024 443906008000 Asp-tRNAAsn/Glu-tRNAGln amidotransferase A subunit and related amidases [Translation, ribosomal structure and biogenesis]; Region: GatA; COG0154 443906008001 Amidase; Region: Amidase; cl11426 443906008002 PAP2, bacterial acid phosphatase or class A non-specific acid phosphatases. These enzymes catalyze phosphomonoester hydrolysis, with optimal activity in low pH conditions. They are secreted into the periplasmic space, and their physiological role remains...; Region: PAP2_acid_phosphatase; cd03397 443906008003 active site 443906008004 Membrane-associated phospholipid phosphatase [Lipid metabolism]; Region: PgpB; COG0671 443906008005 Beta-lactamase; Region: Beta-lactamase; pfam00144 443906008006 Beta-lactamase class C and other penicillin binding proteins [Defense mechanisms]; Region: AmpC; COG1680 443906008007 MarR family; Region: MarR; pfam01047 443906008008 hypothetical protein; Provisional; Region: PRK07236 443906008009 hypothetical protein; Provisional; Region: PRK07588 443906008010 Nitroreductase-like family 2. A subfamily of the nitroreductase family containing uncharacterized proteins that are similar to nitroreductase. Nitroreductase catalyzes the reduction of nitroaromatic compounds such as nitrotoluenes, nitrofurans and...; Region: Nitroreductase_2; cd02138 443906008011 putative FMN binding site [chemical binding]; other site 443906008012 Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673 443906008013 Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408 443906008014 Oxidoreductase family, C-terminal alpha/beta domain; Region: GFO_IDH_MocA_C; pfam02894 443906008015 Type 1 glutamine amidotransferase (GATase1)-like domain; Region: GAT_1; cl00020 443906008016 conserved cys residue [active] 443906008017 ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132 443906008018 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 443906008019 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 443906008020 Walker A/P-loop; other site 443906008021 ATP binding site [chemical binding]; other site 443906008022 Q-loop/lid; other site 443906008023 ABC transporter signature motif; other site 443906008024 Walker B; other site 443906008025 D-loop; other site 443906008026 H-loop/switch region; other site 443906008027 Ferritin-like superfamily of diiron-containing four-helix-bundle proteins; Region: Ferritin_like; cl00264 443906008028 dinuclear metal binding motif [ion binding]; other site 443906008029 Predicted membrane protein [Function unknown]; Region: COG2261 443906008030 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 443906008031 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 443906008032 active site 443906008033 phosphorylation site [posttranslational modification] 443906008034 intermolecular recognition site; other site 443906008035 dimerization interface [polypeptide binding]; other site 443906008036 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 443906008037 DNA binding residues [nucleotide binding] 443906008038 dimerization interface [polypeptide binding]; other site 443906008039 Fic/DOC family; Region: Fic; cl00960 443906008040 VbhA antitoxin and related proteins; Region: VbhA_like; cd11586 443906008041 Microcin C7 self-immunity protein determines resistance to exogenous microcin C7; Region: Peptidase_S66_mccF_like; cd07062 443906008042 putative dimer interface [polypeptide binding]; other site 443906008043 catalytic triad [active] 443906008044 Protein of unknown function (DUF1266); Region: DUF1266; cl14673 443906008045 Lipopolysaccharide heptosyltransferase is involved in the biosynthesis of lipooligosaccharide (LOS). Lipopolysaccharide (LPS) is a major component of the outer membrane of gram-negative bacteria. LPS heptosyltransferase transfers heptose molecules from...; Region: GT1_LPS_heptosyltransferase; cd03789 443906008046 ADP-heptose:LPS heptosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaF; COG0859 443906008047 putative active site [active] 443906008048 Uncharacterized membrane-associated protein [Function unknown]; Region: DedA; COG0586 443906008049 SNARE associated Golgi protein; Region: SNARE_assoc; cl00429 443906008050 Beta-lactamase enzyme family; Region: Beta-lactamase2; pfam13354 443906008051 helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347 443906008052 MarR family; Region: MarR; pfam01047 443906008053 Exonuclease-Endonuclease-Phosphatase domain; uncharacterized family 1; Region: EEP-1; cd09083 443906008054 putative catalytic site [active] 443906008055 putative metal binding site [ion binding]; other site 443906008056 putative phosphate binding site [ion binding]; other site 443906008057 Histidinol phosphatase and related phosphatases [Amino acid transport and metabolism]; Region: HisB; COG0241 443906008058 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 443906008059 active site 443906008060 motif I; other site 443906008061 motif II; other site 443906008062 ADP-heptose:LPS heptosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaF; COG0859 443906008063 Lipopolysaccharide heptosyltransferase is involved in the biosynthesis of lipooligosaccharide (LOS). Lipopolysaccharide (LPS) is a major component of the outer membrane of gram-negative bacteria. LPS heptosyltransferase transfers heptose molecules from...; Region: GT1_LPS_heptosyltransferase; cd03789 443906008064 putative active site [active] 443906008065 Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013 443906008066 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 443906008067 This family is most closely related to the GT1 family of glycosyltransferases. The sucrose-phosphate synthases in this family may be unique to plants and photosynthetic bacteria. This enzyme catalyzes the synthesis of sucrose 6-phosphate from fructose...; Region: GT1_Sucrose_synthase; cd03800 443906008068 Glycosyltransferase Family 4; Region: Glyco_transf_4; pfam13439 443906008069 putative ADP-binding pocket [chemical binding]; other site 443906008070 Phosphoheptose isomerase is a member of the SIS (Sugar ISomerase) superfamily. Phosphoheptose isomerase catalyzes the isomerization of sedoheptulose 7-phosphate into D-glycero-D-mannoheptose 7-phosphate. This is the first step of the biosynthesis of...; Region: SIS_GmhA; cd05006 443906008071 dimer interface [polypeptide binding]; other site 443906008072 active site 443906008073 ADP-heptose synthase, bifunctional sugar kinase/adenylyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaE; COG2870 443906008074 ribokinase/pfkB superfamily: Kinases that accept a wide variety of substrates, including carbohydrates and aromatic small molecules, all are phosphorylated at a hydroxyl group. The superfamily includes ribokinase, fructokinase, ketohexokinase; Region: ribokinase_pfkB_like; cl00192 443906008075 nucleotidyl transferase superfamily; Region: nt_trans; cl00015 443906008076 active site 443906008077 HIGH motif; other site 443906008078 nucleotide binding site [chemical binding]; other site 443906008079 classical (c) SDRs; Region: SDR_c; cd05233 443906008080 NAD(P) binding site [chemical binding]; other site 443906008081 active site 443906008082 Cutinase; Region: Cutinase; pfam01083 443906008083 multifunctional fatty acid oxidation complex subunit alpha; Reviewed; Region: fadB; PRK11730 443906008084 Beta-mannanase [Carbohydrate transport and metabolism]; Region: ManB; COG4124 443906008085 Beta-mannanase [Carbohydrate transport and metabolism]; Region: ManB; COG4124 443906008086 Alpha/beta hydrolase; Region: Abhydrolase_8; pfam06259 443906008087 Virulence protein [General function prediction only]; Region: COG3943 443906008088 Virulence protein RhuM family; Region: Virulence_RhuM; pfam13310 443906008089 ADP-heptose:LPS heptosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaF; COG0859 443906008090 Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013 443906008091 Transcriptional regulators [Transcription]; Region: PurR; COG1609 443906008092 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 443906008093 DNA binding site [nucleotide binding] 443906008094 domain linker motif; other site 443906008095 Ligand-binding domain of DNA transcription repressor LacI specific for lactose, a member of the LacI-GalR family of bacterial transcription regulators; Region: PBP1_LacI; cd01574 443906008096 ligand binding site [chemical binding]; other site 443906008097 dimerization interface (open form) [polypeptide binding]; other site 443906008098 dimerization interface (closed form) [polypeptide binding]; other site 443906008099 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cl00427 443906008100 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 443906008101 dimer interface [polypeptide binding]; other site 443906008102 ABC-ATPase subunit interface; other site 443906008103 putative PBP binding loops; other site 443906008104 ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395 443906008105 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 443906008106 dimer interface [polypeptide binding]; other site 443906008107 conserved gate region; other site 443906008108 putative PBP binding loops; other site 443906008109 ABC-ATPase subunit interface; other site 443906008110 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; pfam01547 443906008111 Bacterial extracellular solute-binding protein; Region: SBP_bac_8; pfam13416 443906008112 Glycosyl hydrolases family 35; Region: Glyco_hydro_35; pfam01301 443906008113 Aldehyde dehydrogenase family; Region: Aldedh; pfam00171 443906008114 NAD(P)+ dependent aldehyde dehydrogenase family; Region: ALDH; cd07078 443906008115 NAD(P) binding site [chemical binding]; other site 443906008116 catalytic residues [active] 443906008117 ADP-heptose synthase, bifunctional sugar kinase/adenylyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaE; COG2870 443906008118 ribokinase/pfkB superfamily: Kinases that accept a wide variety of substrates, including carbohydrates and aromatic small molecules, all are phosphorylated at a hydroxyl group. The superfamily includes ribokinase, fructokinase, ketohexokinase; Region: ribokinase_pfkB_like; cl00192 443906008119 substrate binding site [chemical binding]; other site 443906008120 ATP binding site [chemical binding]; other site 443906008121 rfaE bifunctional protein, domain II; Region: rfaE_dom_II; TIGR02199 443906008122 active site 443906008123 nucleotide binding site [chemical binding]; other site 443906008124 HIGH motif; other site 443906008125 KMSKS motif; other site 443906008126 Protein of unknown function (DUF2795); Region: DUF2795; pfam11387 443906008127 Uncharacterized protein conserved in bacteria (DUF2087); Region: DUF2087; pfam09860 443906008128 Zeta toxin; Region: Zeta_toxin; pfam06414 443906008129 Helix-turn-helix domain; Region: HTH_17; pfam12728 443906008130 Membrane proteins related to metalloendopeptidases [Cell envelope biogenesis, outer membrane]; Region: NlpD; COG0739 443906008131 Peptidase family M23; Region: Peptidase_M23; pfam01551 443906008132 AAA-like domain; Region: AAA_10; pfam12846 443906008133 Type IV secretory pathway, VirD4 components [Intracellular trafficking and secretion]; Region: VirD4; COG3505 443906008134 RecA-like NTPases. This family includes the NTP binding domain of F1 and V1 H+ATPases, DnaB and related helicases as well as bacterial RecA and related eukaryotic and archaeal recombinases. This group also includes bacterial conjugation proteins and...; Region: RecA-like_NTPases; cl17233 443906008135 Walker A motif; other site 443906008136 ATP binding site [chemical binding]; other site 443906008137 TraM recognition site of TraD and TraG; Region: TraG-D_C; pfam12696 443906008138 Poxvirus A21 Protein; Region: Pox_A21; cl17408 443906008139 FOG: GAF domain [Signal transduction mechanisms]; Region: FhlA; COG2203 443906008140 GAF domain; Region: GAF; pfam01590 443906008141 Stage II sporulation protein E (SpoIIE); Region: SpoIIE; pfam07228 443906008142 Serine phosphatase RsbU, regulator of sigma subunit [Signal transduction mechanisms / Transcription]; Region: RsbU; COG2208 443906008143 Stage II sporulation protein E (SpoIIE); Region: SpoIIE; pfam07228 443906008144 Histidine kinase-like ATPase domain; Region: HATPase_c_2; pfam13581 443906008145 Sulphate Transporter and Anti-Sigma factor antagonist) domain of anti-anti-sigma factors, key regulators of anti-sigma factors by phosphorylation; Region: STAS_anti-anti-sigma_factors; cd07043 443906008146 anti sigma factor interaction site; other site 443906008147 regulatory phosphorylation site [posttranslational modification]; other site 443906008148 Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067 443906008149 catalytic core [active] 443906008150 Acetyltransferase (GNAT) domain; Region: Acetyltransf_10; pfam13673 443906008151 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 443906008152 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl17182 443906008153 Coenzyme A binding pocket [chemical binding]; other site 443906008154 Protein of unknown function (DUF3494); Region: DUF3494; pfam11999 443906008155 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 443906008156 dimer interface [polypeptide binding]; other site 443906008157 conserved gate region; other site 443906008158 putative PBP binding loops; other site 443906008159 ABC-ATPase subunit interface; other site 443906008160 ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395 443906008161 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 443906008162 dimer interface [polypeptide binding]; other site 443906008163 conserved gate region; other site 443906008164 putative PBP binding loops; other site 443906008165 ABC-ATPase subunit interface; other site 443906008166 Small Multidrug Resistance protein; Region: Multi_Drug_Res; cl00910 443906008167 ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653 443906008168 Protein of unknown function (DUF2424); Region: DUF2424; pfam10340 443906008169 alpha/beta hydrolase fold; Region: Abhydrolase_3; pfam07859 443906008170 Bacterial fructose-1,6-bisphosphatase, glpX-encoded. A dimeric enzyme dependent on Mg(2+). glpX-encoded FPBase (FBPase class II) differs from other members of the inositol-phosphatase superfamily by permutation of secondary structure elements. The core...; Region: FBPase_glpX; cd01516 443906008171 Bacterial fructose-1,6-bisphosphatase, glpX-encoded; Region: FBPase_glpX; pfam03320 443906008172 putative active site [active] 443906008173 Predicted permease, member of the PurR regulon [General function prediction only]; Region: yhhT; COG0628 443906008174 Domain of unknown function DUF20; Region: UPF0118; pfam01594 443906008175 ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136 443906008176 ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255 443906008177 Walker A/P-loop; other site 443906008178 ATP binding site [chemical binding]; other site 443906008179 Q-loop/lid; other site 443906008180 ABC transporter signature motif; other site 443906008181 Walker B; other site 443906008182 D-loop; other site 443906008183 H-loop/switch region; other site 443906008184 MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704 443906008185 ABC-type antimicrobial peptide transport system, permease component [Defense mechanisms]; Region: SalY; COG0577 443906008186 FtsX-like permease family; Region: FtsX; pfam02687 443906008187 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: COG4585 443906008188 Histidine kinase; Region: HisKA_3; pfam07730 443906008189 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 443906008190 ATP binding site [chemical binding]; other site 443906008191 Mg2+ binding site [ion binding]; other site 443906008192 G-X-G motif; other site 443906008193 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 443906008194 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 443906008195 active site 443906008196 phosphorylation site [posttranslational modification] 443906008197 intermolecular recognition site; other site 443906008198 dimerization interface [polypeptide binding]; other site 443906008199 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 443906008200 DNA binding residues [nucleotide binding] 443906008201 dimerization interface [polypeptide binding]; other site 443906008202 Haloacid dehalogenase-like hydrolase; Region: HAD_2; pfam13419 443906008203 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 443906008204 motif II; other site 443906008205 ANTAR domain; Region: ANTAR; pfam03861 443906008206 ANTAR (AmiR and NasR transcription antitermination regulators) is an RNA-binding domain found in bacterial transcription antitermination regulatory proteins; Region: ANTAR; smart01012 443906008207 Predicted dinucleotide-binding enzymes [General function prediction only]; Region: COG2085 443906008208 NADP oxidoreductase coenzyme F420-dependent; Region: F420_oxidored; pfam03807 443906008209 NADP oxidoreductase coenzyme F420-dependent; Region: F420_oxidored; cl17232 443906008210 hypothetical protein; Provisional; Region: PRK10621 443906008211 Sulfite exporter TauE/SafE; Region: TauE; pfam01925 443906008212 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 443906008213 non-specific DNA binding site [nucleotide binding]; other site 443906008214 salt bridge; other site 443906008215 sequence-specific DNA binding site [nucleotide binding]; other site 443906008216 HipA N-terminal domain; Region: Couple_hipA; pfam13657 443906008217 HipA-like N-terminal domain; Region: HipA_N; pfam07805 443906008218 HipA-like C-terminal domain; Region: HipA_C; pfam07804 443906008219 potassium-transporting ATPase subunit A; Provisional; Region: PRK05482 443906008220 potassium-transporting ATPase subunit B; Provisional; Region: PRK01122 443906008221 E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122 443906008222 Soluble P-type ATPase [General function prediction only]; Region: COG4087 443906008223 K+-transporting ATPase, c chain [Inorganic ion transport and metabolism]; Region: KdpC; COG2156 443906008224 Osmosensitive K+ channel His kinase sensor domain; Region: KdpD; pfam02702 443906008225 Osmosensitive K+ channel histidine kinase [Signal transduction mechanisms]; Region: KdpD; COG2205 443906008226 USP domain is located between the N-terminal sensor domain and C-terminal catalytic domain of this Osmosensitive K+ channel histidine kinase family. The family of KdpD sensor kinase proteins regulates the kdpFABC operon responsible for potassium...; Region: USP_OKCHK; cd01987 443906008227 Ligand Binding Site [chemical binding]; other site 443906008228 His Kinase A (phosphoacceptor) domain; Region: HisKA; smart00388 443906008229 dimer interface [polypeptide binding]; other site 443906008230 phosphorylation site [posttranslational modification] 443906008231 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 443906008232 ATP binding site [chemical binding]; other site 443906008233 Mg2+ binding site [ion binding]; other site 443906008234 G-X-G motif; other site 443906008235 DNA-binding transcriptional activator KdpE; Provisional; Region: PRK10529 443906008236 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 443906008237 active site 443906008238 phosphorylation site [posttranslational modification] 443906008239 intermolecular recognition site; other site 443906008240 dimerization interface [polypeptide binding]; other site 443906008241 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 443906008242 DNA binding site [nucleotide binding] 443906008243 GDSL-like Lipase/Acylhydrolase family; Region: Lipase_GDSL_2; pfam13472 443906008244 active site 443906008245 catalytic triad [active] 443906008246 oxyanion hole [active] 443906008247 DNA repair protein RadA; Provisional; Region: PRK11823 443906008248 RecA-like NTPases. This family includes the NTP binding domain of F1 and V1 H+ATPases, DnaB and related helicases as well as bacterial RecA and related eukaryotic and archaeal recombinases. This group also includes bacterial conjugation proteins and...; Region: RecA-like_NTPases; cl17233 443906008249 Walker A motif; other site 443906008250 ATP binding site [chemical binding]; other site 443906008251 Walker B motif; other site 443906008252 Subunit ChlI of Mg-chelatase; Region: ChlI; pfam13541 443906008253 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 443906008254 dimerization interface [polypeptide binding]; other site 443906008255 putative DNA binding site [nucleotide binding]; other site 443906008256 putative Zn2+ binding site [ion binding]; other site 443906008257 N-acetylglutamate synthase; Validated; Region: PRK07922 443906008258 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 443906008259 dimer interface [polypeptide binding]; other site 443906008260 phosphorylation site [posttranslational modification] 443906008261 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 443906008262 ATP binding site [chemical binding]; other site 443906008263 Mg2+ binding site [ion binding]; other site 443906008264 G-X-G motif; other site 443906008265 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 443906008266 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 443906008267 active site 443906008268 phosphorylation site [posttranslational modification] 443906008269 intermolecular recognition site; other site 443906008270 dimerization interface [polypeptide binding]; other site 443906008271 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 443906008272 DNA binding site [nucleotide binding] 443906008273 integral membrane protein, TerC family; Region: R_switched_Alx; TIGR03718 443906008274 Periplasmic component of the Tol biopolymer transport system [Intracellular trafficking and secretion]; Region: TolB; COG0823 443906008275 Sugar phosphate isomerases/epimerases [Carbohydrate transport and metabolism]; Region: IolE; COG1082 443906008276 AP endonuclease family 2; These endonucleases play a role in DNA repair. Cleave phosphodiester bonds at apurinic or apyrimidinic sites; the alignment also contains hexulose-6-phosphate isomerases, enzymes that catalyze the epimerization of...; Region: AP2Ec; cl12060 443906008277 Metal-binding active site; metal-binding site 443906008278 AP endonuclease family 2 C terminus; Region: AP_endonuc_2_N; pfam07582 443906008279 ABC-type branched-chain amino acid transport systems, ATPase component [Amino acid transport and metabolism]; Region: LivG; COG0411 443906008280 ATP-binding cassette domain of the drug resistance transporter and related proteins, subfamily A; Region: ABC_DR_subfamily_A; cd03230 443906008281 Walker A/P-loop; other site 443906008282 ATP binding site [chemical binding]; other site 443906008283 Q-loop/lid; other site 443906008284 ABC transporter signature motif; other site 443906008285 Walker B; other site 443906008286 D-loop; other site 443906008287 H-loop/switch region; other site 443906008288 This family is the oxydase domain of NRPS (non-ribosomal peptide synthetase) and other proteins that modify polypeptides by cyclizing a thioester to form a ring. These include epoB, part of the epothilone biosynthesis pathway; tubD, part of the tubulysin...; Region: mcbC-like_oxidoreductase; cd02142 443906008289 putative FMN binding site [chemical binding]; other site 443906008290 NADPH bind site [chemical binding]; other site 443906008291 YcaO-like family; Region: YcaO; pfam02624 443906008292 thiazole/oxazole-forming peptide maturase, SagD family component; Region: TOMM_cyclo_SagD; TIGR03604 443906008293 YqaJ-like viral recombinase domain; Region: YqaJ; pfam09588 443906008294 NADPH:quinone reductase and related Zn-dependent oxidoreductases [Energy production and conversion / General function prediction only]; Region: Qor; COG0604 443906008295 alcohol dehydrogenase and quinone reductase-like medium chain degydrogenases/reductases; Region: MDR_like_2; cd05289 443906008296 putative NAD(P) binding site [chemical binding]; other site 443906008297 Beta-lactamase; Region: Beta-lactamase; pfam00144 443906008298 Beta-lactamase class C and other penicillin binding proteins [Defense mechanisms]; Region: AmpC; COG1680 443906008299 Glycosyl hydrolase families 32 and 68, which for the clan GH-J; Region: GH_J; cd08979 443906008300 active site 443906008301 ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395 443906008302 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 443906008303 dimer interface [polypeptide binding]; other site 443906008304 conserved gate region; other site 443906008305 putative PBP binding loops; other site 443906008306 ABC-ATPase subunit interface; other site 443906008307 ABC-type sugar transport systems, permease components [Carbohydrate transport and metabolism]; Region: UgpA; COG1175 443906008308 Maltose-binding periplasmic proteins/domains [Carbohydrate transport and metabolism]; Region: MalE; COG2182 443906008309 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; pfam01547 443906008310 Transcriptional regulators [Transcription]; Region: PurR; COG1609 443906008311 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 443906008312 DNA binding site [nucleotide binding] 443906008313 domain linker motif; other site 443906008314 Ligand-binding domain of DNA-binding regulatory proteins specific to sucrose that are members of the LacI-GalR family of bacterial transcription repressors; Region: PBP1_sucrose_transcription_regulator; cd06288 443906008315 putative dimerization interface [polypeptide binding]; other site 443906008316 putative ligand binding site [chemical binding]; other site 443906008317 Acetyltransferase (GNAT) family; Region: Acetyltransf_1; pfam00583 443906008318 Ribosomal protein L1. The L1 protein, located near the E-site of the ribosome, forms part of the L1 stalk along with 23S rRNA. In bacteria and archaea, L1 functions both as a ribosomal protein that binds rRNA, and as a translation repressor that binds...; Region: Ribosomal_L1; cd00403 443906008319 mRNA/rRNA interface [nucleotide binding]; other site 443906008320 50S ribosomal protein L11; Validated; Region: rplK; PRK00140 443906008321 Ribosomal protein L11. Ribosomal protein L11, together with proteins L10 and L7/L12, and 23S rRNA, form the L7/L12 stalk on the surface of the large subunit of the ribosome. The homologous eukaryotic cytoplasmic protein is also called 60S ribosomal...; Region: Ribosomal_L11; cd00349 443906008322 23S rRNA interface [nucleotide binding]; other site 443906008323 L7/L12 interface [polypeptide binding]; other site 443906008324 putative thiostrepton binding site; other site 443906008325 L25 interface [polypeptide binding]; other site 443906008326 transcription antitermination protein NusG; Validated; Region: nusG; PRK05609 443906008327 Bacterial N-Utilization Substance G (NusG) N-terminal (NGN) domain, subgroup 1; Region: NGN_Bact_1; cd09891 443906008328 putative homodimer interface [polypeptide binding]; other site 443906008329 NusG contains an NGN domain at its N-terminus and KOW motif at its C-terminus; Region: KOW_NusG; cd06091 443906008330 heterodimer interface [polypeptide binding]; other site 443906008331 homodimer interface [polypeptide binding]; other site 443906008332 preprotein translocase subunit SecE; Reviewed; Region: secE; PRK07597 443906008333 aspartate aminotransferase; Provisional; Region: PRK05764 443906008334 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 443906008335 pyridoxal 5'-phosphate binding site [chemical binding]; other site 443906008336 homodimer interface [polypeptide binding]; other site 443906008337 catalytic residue [active] 443906008338 UDP-N-acetylenolpyruvoylglucosamine reductase; Provisional; Region: murB; PRK13903 443906008339 FAD binding domain; Region: FAD_binding_4; pfam01565 443906008340 UDP-N-acetylenolpyruvoylglucosamine reductase, C-terminal domain; Region: MurB_C; pfam02873 443906008341 The hotdog fold was initially identified in the E. coli FabA (beta-hydroxydecanoyl-acyl carrier protein (ACP)-dehydratase) structure and subsequently in 4HBT (4-hydroxybenzoyl-CoA thioesterase) from Pseudomonas. A number of other seemingly unrelated...; Region: hot_dog; cl00509 443906008342 active site 2 [active] 443906008343 active site 1 [active] 443906008344 (R)-hydratase [(R)-specific enoyl-CoA hydratase]. Catalyzes the hydration of trans-2-enoyl CoA to (R)-3-hydroxyacyl-CoA as part of the PHA (polyhydroxyalkanoate) biosynthetic pathway. The structure of the monomer includes a five-strand antiparallel...; Region: R_hydratase_like; cd03441 443906008345 active site 443906008346 catalytic site [active] 443906008347 similar to hypothetical protein; hypothetical protein (NP_787847.1| hypothetical protein TWT719 [Tropheryma whipplei str. Twist]; YP_061785.1| hypothetical protein Lxx07640 [Leifsonia xyli subsp. xyli str. CTCB07]). 443906008348 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 443906008349 Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248 443906008350 active site 443906008351 catalytic tetrad [active] 443906008352 Alpha amylase catalytic domain found in oligo-1,6-glucosidase (also called isomaltase; sucrase-isomaltase; alpha-limit dextrinase), trehalose synthase (also called maltose alpha-D-glucosyltransferase), and related proteins; Region: AmyAc_OligoGlu_TS; cd11332 443906008353 alpha,alpha-phosphotrehalase; Region: trehalose_treC; TIGR02403 443906008354 active site 443906008355 catalytic site [active] 443906008356 Domain of unknown function (DUF3459); Region: DUF3459; pfam11941 443906008357 Membrane proteins related to metalloendopeptidases [Cell envelope biogenesis, outer membrane]; Region: NlpD; COG0739 443906008358 Peptidase family M23; Region: Peptidase_M23; pfam01551 443906008359 Archaeal fructose-1,6-bisphosphatase and related enzymes of inositol monophosphatase family [Carbohydrate transport and metabolism]; Region: SuhB; COG0483 443906008360 IMPase, inositol monophosphatase and related domains. A family of Mg++ dependent phosphatases, inhibited by lithium, many of which may act on inositol monophosphate substrate. They dephosphorylate inositol phosphate to generate inositol, which may be...; Region: IMPase; cd01639 443906008361 active site 443906008362 dimerization interface [polypeptide binding]; other site 443906008363 Protein of unknown function (DUF1275); Region: DUF1275; pfam06912 443906008364 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 443906008365 Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248 443906008366 active site 443906008367 catalytic tetrad [active] 443906008368 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG1666 443906008369 Proteins similar to Escherichia coli YajQ; Region: YajQ_like; cd11740 443906008370 Phospholipase_D-nuclease N-terminal; Region: PLDc_N; pfam13396 443906008371 cardiolipin synthetase; Reviewed; Region: cls; PRK01642 443906008372 Catalytic domain, repeat 1, of Escherichia coli cardiolipin synthase and similar proteins; Region: PLDc_EcCLS_like_1; cd09152 443906008373 putative active site [active] 443906008374 catalytic site [active] 443906008375 Catalytic domain, repeat 2, of Escherichia coli cardiolipin synthase and similar proteins; Region: PLDc_EcCLS_like_2; cd09158 443906008376 putative active site [active] 443906008377 catalytic site [active] 443906008378 helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347 443906008379 MarR family; Region: MarR; pfam01047 443906008380 ferredoxin-NADP+ reductase; Region: PLN02852 443906008381 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500 443906008382 Geranylgeranyl pyrophosphate synthase [Coenzyme metabolism]; Region: IspA; COG0142 443906008383 Trans-Isoprenyl Diphosphate Synthases, head-to-tail; Region: Trans_IPPS_HT; cd00685 443906008384 substrate binding pocket [chemical binding]; other site 443906008385 chain length determination region; other site 443906008386 substrate-Mg2+ binding site; other site 443906008387 catalytic residues [active] 443906008388 aspartate-rich region 1; other site 443906008389 active site lid residues [active] 443906008390 aspartate-rich region 2; other site 443906008391 Methylase involved in ubiquinone/menaquinone biosynthesis [Coenzyme metabolism]; Region: UbiE; COG2226 443906008392 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 443906008393 chorismate binding enzyme; Region: Chorismate_bind; pfam00425 443906008394 2-succinyl-5-enolpyruvyl-6-hydroxy-3-cyclohexene-1- carboxylate synthase; Validated; Region: PRK07449 443906008395 Pyrimidine (PYR) binding domain of 2-succinyl-5-enolpyruvyl-6-hydroxy-3-cyclohexadiene-1- carboxylate synthase (MenD) and related proteins; Region: TPP_PYR_MenD; cd07037 443906008396 dimer interface [polypeptide binding]; other site 443906008397 tetramer interface [polypeptide binding]; other site 443906008398 PYR/PP interface [polypeptide binding]; other site 443906008399 TPP binding site [chemical binding]; other site 443906008400 Thiamine pyrophosphate (TPP) family, SHCHC synthase subfamily, TPP-binding module; composed of proteins similar to Escherichia coli 2-succinyl-6-hydroxyl-2,4-cyclohexadiene-1-carboxylic acid (SHCHC) synthase (also called MenD). SHCHC synthase plays a key...; Region: TPP_SHCHC_synthase; cd02009 443906008401 TPP-binding site; other site 443906008402 Protein of unknown function (DUF4229); Region: DUF4229; pfam14012 443906008403 1,4-dihydroxy-2-naphthoate octaprenyltransferase; Validated; Region: PRK06080 443906008404 UbiA prenyltransferase family; Region: UbiA; pfam01040 443906008405 Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067 443906008406 catalytic core [active] 443906008407 Beta-lactamase enzyme family; Region: Beta-lactamase2; pfam13354 443906008408 Predicted metalloendopeptidase [Posttranslational modification, protein turnover, chaperones]; Region: PepO; COG3590 443906008409 Peptidase family M13 includes neprilysin, endothelin-converting enzyme I; Region: M13; cd08662 443906008410 active site 443906008411 Zn binding site [ion binding]; other site 443906008412 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 443906008413 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 443906008414 non-specific DNA binding site [nucleotide binding]; other site 443906008415 salt bridge; other site 443906008416 sequence-specific DNA binding site [nucleotide binding]; other site 443906008417 pyrimidine utilization transport protein G; Region: RutG; TIGR03616 443906008418 allophanate hydrolase; Provisional; Region: PRK08186 443906008419 Amidase; Region: Amidase; cl11426 443906008420 Isochorismatase family; Region: Isochorismatase; pfam00857 443906008421 Cysteine hydrolases; This family contains amidohydrolases, like CSHase (N-carbamoylsarcosine amidohydrolase), involved in creatine metabolism and nicotinamidase, converting nicotinamide to nicotinic acid and ammonia in the pyridine nucleotide cycle. It...; Region: cysteine_hydrolases; cd00431 443906008422 catalytic triad [active] 443906008423 conserved cis-peptide bond; other site 443906008424 Solute carrier families 5 and 6-like; solute binding domain; Region: SLC5-6-like_sbd; cl00456 443906008425 Na binding site [ion binding]; other site 443906008426 Transcriptional regulators [Transcription]; Region: GntR; COG1802 443906008427 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cl17414 443906008428 DNA-binding site [nucleotide binding]; DNA binding site 443906008429 FCD domain; Region: FCD; pfam07729 443906008430 Predicted phosphatases [General function prediction only]; Region: Gph; COG0546 443906008431 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 443906008432 motif II; other site 443906008433 helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347 443906008434 MarR family; Region: MarR_2; cl17246 443906008435 Homocysteine S-methyltransferase; Region: S-methyl_trans; pfam02574 443906008436 homocysteine methyltransferase; Provisional; Region: mmuM; PRK09485 443906008437 Predicted nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: COG0702 443906008438 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 443906008439 NAD(P) binding site [chemical binding]; other site 443906008440 active site 443906008441 Predicted transcriptional regulators [Transcription]; Region: COG1733 443906008442 HxlR-like helix-turn-helix; Region: HxlR; pfam01638 443906008443 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 443906008444 Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248 443906008445 active site 443906008446 catalytic tetrad [active] 443906008447 Transcriptional regulator [Transcription]; Region: LysR; COG0583 443906008448 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cd05466 443906008449 dimerization interface [polypeptide binding]; other site 443906008450 EamA-like transporter family; Region: EamA; pfam00892 443906008451 Domain of unknown function (DUF202); Region: DUF202; cl09954 443906008452 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 443906008453 NADH(P)-binding; Region: NAD_binding_10; pfam13460 443906008454 NAD(P) binding site [chemical binding]; other site 443906008455 active site 443906008456 Sugar kinases, ribokinase family [Carbohydrate transport and metabolism]; Region: RbsK; COG0524 443906008457 ribokinase/pfkB superfamily: Kinases that accept a wide variety of substrates, including carbohydrates and aromatic small molecules, all are phosphorylated at a hydroxyl group. The superfamily includes ribokinase, fructokinase, ketohexokinase; Region: ribokinase_pfkB_like; cl00192 443906008458 substrate binding site [chemical binding]; other site 443906008459 ATP binding site [chemical binding]; other site 443906008460 Transcriptional regulators [Transcription]; Region: PurR; COG1609 443906008461 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 443906008462 DNA binding site [nucleotide binding] 443906008463 domain linker motif; other site 443906008464 Ligand binding domain of the LacI tanscriptional regulator family belonging to the type I periplasmic-binding fold protein superfamily; Region: PBP1_LacI_sugar_binding_like; cd06267 443906008465 dimerization interface [polypeptide binding]; other site 443906008466 ligand binding site [chemical binding]; other site 443906008467 Periplasmic sugar-binding domain of active transport systems that are members of the type I periplasmic binding protein (PBP1) superfamily; Region: PBP1_ABC_sugar_binding_like; cd01536 443906008468 Periplasmic binding protein domain; Region: Peripla_BP_4; pfam13407 443906008469 ligand binding site [chemical binding]; other site 443906008470 Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653 443906008471 Transmembrane subunit (TM) of Escherichia coli AraH and related proteins. E. coli AraH is the TM of a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of the monosaccharide arabinose. This group...; Region: TM_PBP1_transp_AraH_like; cd06579 443906008472 TM-ABC transporter signature motif; other site 443906008473 ABC-type branched-chain amino acid transport systems, ATPase component [Amino acid transport and metabolism]; Region: LivG; COG0411 443906008474 First domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_I; cd03216 443906008475 Walker A/P-loop; other site 443906008476 ATP binding site [chemical binding]; other site 443906008477 Q-loop/lid; other site 443906008478 ABC transporter signature motif; other site 443906008479 Walker B; other site 443906008480 D-loop; other site 443906008481 H-loop/switch region; other site 443906008482 Uncharacterized conserved protein [Function unknown]; Region: COG1359 443906008483 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 443906008484 non-specific DNA binding site [nucleotide binding]; other site 443906008485 salt bridge; other site 443906008486 sequence-specific DNA binding site [nucleotide binding]; other site 443906008487 Domain of unknown function (DUF955); Region: DUF955; cl01076 443906008488 Plasmid maintenance system killer protein; Region: Plasmid_killer; cl01422 443906008489 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 443906008490 3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05653 443906008491 NAD(P) binding site [chemical binding]; other site 443906008492 active site 443906008493 Bacterial protein of unknown function (DUF839); Region: DUF839; pfam05787 443906008494 Predicted divalent heavy-metal cations transporter [Inorganic ion transport and metabolism]; Region: COG0428; cl00437 443906008495 Transcriptional regulators [Transcription]; Region: MarR; COG1846 443906008496 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 443906008497 putative Zn2+ binding site [ion binding]; other site 443906008498 putative DNA binding site [nucleotide binding]; other site 443906008499 The Fer4_NifH superfamily contains a variety of proteins which share a common ATP-binding domain. Functionally, proteins in this superfamily use the energy from hydrolysis of NTP to transfer electron or ion; Region: Fer4_NifH; cl17203 443906008500 ATPases involved in chromosome partitioning [Cell division and chromosome partitioning]; Region: Soj; COG1192 443906008501 DinF and similar proteins, a subfamily of the multidrug and toxic compound extrusion (MATE)-like proteins; Region: MATE_DinF_like; cd13136 443906008502 Na+-driven multidrug efflux pump [Defense mechanisms]; Region: NorM; COG0534 443906008503 Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248 443906008504 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 443906008505 active site 443906008506 catalytic tetrad [active] 443906008507 Putative protein-S-isoprenylcysteine methyltransferase [Posttranslational modification, protein turnover, chaperones]; Region: STE14; COG2020 443906008508 ASC-1 homology domain, subfamily similar to Enterococcus faecalis Ef3133. The ASCH domain, a small beta-barrel domain found in all three kingdoms of life, resembles the RNA-binding PUA domain and may also interact with RNA. ASCH has been proposed to...; Region: ASCH_Ef3133_like; cd06553 443906008509 Acetyltransferase (GNAT) domain; Region: Acetyltransf_3; pfam13302 443906008510 Acetyltransferase (GNAT) domain; Region: Acetyltransf_3; pfam13302 443906008511 Protein of unknown function (DUF1211); Region: DUF1211; pfam06736 443906008512 Permeases of the drug/metabolite transporter (DMT) superfamily [Carbohydrate transport and metabolism / Amino acid transport and metabolism / General function prediction only]; Region: RhaT; COG0697 443906008513 EamA-like transporter family; Region: EamA; pfam00892 443906008514 Predicted nuclease of the RecB family [DNA replication, recombination, and repair]; Region: COG1637 443906008515 hypothetical protein; Provisional; Region: PRK03298 443906008516 Predicted phosphatases [General function prediction only]; Region: Gph; COG0546 443906008517 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 443906008518 motif II; other site 443906008519 helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347 443906008520 MarR family; Region: MarR; pfam01047 443906008521 Ferritin-CCC1, N-terminal ferritin-like diiron-binding domain; Region: Ferritin_CCC1_N; cd01044 443906008522 diiron binding motif [ion binding]; other site 443906008523 Nodulin-21 and CCC1-related protein family; Region: Nodulin-21_like_2; cd02433 443906008524 Probable polygalacturonase At3g15720; Region: PLN03003; cl14103 443906008525 Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596 443906008526 diaminobutyrate--2-oxoglutarate aminotransferase; Validated; Region: PRK09264 443906008527 Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610 443906008528 inhibitor-cofactor binding pocket; inhibition site 443906008529 pyridoxal 5'-phosphate binding site [chemical binding]; other site 443906008530 catalytic residue [active] 443906008531 ASC-1 homology domain, subfamily similar to Escherichia coli Yqfb. The ASCH domain, a small beta-barrel domain found in all three kingdoms of life, resembles the RNA-binding PUA domain and may also interact with RNA. ASCH has been proposed to function as...; Region: ASCH_yqfb_like; cd06552 443906008532 SnoaL-like domain; Region: SnoaL_2; pfam12680 443906008533 Response regulator of citrate/malate metabolism [Transcription / Signal transduction mechanisms]; Region: CitB; COG4565 443906008534 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 443906008535 active site 443906008536 phosphorylation site [posttranslational modification] 443906008537 intermolecular recognition site; other site 443906008538 dimerization interface [polypeptide binding]; other site 443906008539 Signal transduction histidine kinase regulating citrate/malate metabolism [Signal transduction mechanisms]; Region: CitA; COG3290 443906008540 PAS domain; Region: PAS; smart00091 443906008541 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 443906008542 ATP binding site [chemical binding]; other site 443906008543 Mg2+ binding site [ion binding]; other site 443906008544 G-X-G motif; other site 443906008545 H+/citrate symporter [Energy production and conversion]; Region: CitM; cl17620 443906008546 Citrate transporter; Region: CitMHS; pfam03600 443906008547 H+/citrate symporter [Energy production and conversion]; Region: CitM; cl17620 443906008548 Citrate transporter; Region: CitMHS; pfam03600 443906008549 Predicted membrane protein (DUF2079); Region: DUF2079; pfam09852 443906008550 Predicted membrane protein [Function unknown]; Region: COG3463 443906008551 Transcriptional regulator [Transcription]; Region: LysR; COG0583 443906008552 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 443906008553 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 443906008554 SGNH_hydrolase, or GDSL_hydrolase, is a diverse family of lipases and esterases. The tertiary fold of the enzyme is substantially different from that of the alpha/beta hydrolase family and unique among all known hydrolases; its active site closely...; Region: SGNH_hydrolase; cl01053 443906008555 active site 443906008556 catalytic triad [active] 443906008557 oxyanion hole [active] 443906008558 prenyltransferase; Reviewed; Region: ubiA; PRK13105 443906008559 UbiA prenyltransferase family; Region: UbiA; pfam01040 443906008560 lycopene cyclase domain; Region: CarR_dom_SF; TIGR03462 443906008561 lycopene cyclase domain; Region: CarR_dom_SF; TIGR03462 443906008562 Trans-Isoprenyl Diphosphate Synthases, head-to-head; Region: Trans_IPPS_HH; cd00683 443906008563 active site lid residues [active] 443906008564 substrate binding pocket [chemical binding]; other site 443906008565 catalytic residues [active] 443906008566 substrate-Mg2+ binding site; other site 443906008567 aspartate-rich region 1; other site 443906008568 aspartate-rich region 2; other site 443906008569 phytoene desaturase; Region: crtI_fam; TIGR02734 443906008570 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450 443906008571 Geranylgeranyl pyrophosphate synthase [Coenzyme metabolism]; Region: IspA; COG0142 443906008572 Trans-Isoprenyl Diphosphate Synthases, head-to-tail; Region: Trans_IPPS_HT; cd00685 443906008573 substrate binding pocket [chemical binding]; other site 443906008574 chain length determination region; other site 443906008575 substrate-Mg2+ binding site; other site 443906008576 catalytic residues [active] 443906008577 aspartate-rich region 1; other site 443906008578 active site lid residues [active] 443906008579 aspartate-rich region 2; other site 443906008580 Isopentenyl diphosphate (IPP) isomerase, a member of the Nudix hydrolase superfamily, is a key enzyme in the isoprenoid biosynthetic pathway. Isoprenoids comprise a large family of natural products including sterols, carotenoids, dolichols and prenylated...; Region: IPP_Isomerase; cd02885 443906008581 isopentenyl-diphosphate delta-isomerase, type 1; Region: IPP_isom_1; TIGR02150 443906008582 active site 443906008583 metal binding site [ion binding]; metal-binding site 443906008584 nudix motif; other site 443906008585 Patatins and Phospholipases; Region: Patatin_and_cPLA2; cl11396 443906008586 nucleophile elbow; other site 443906008587 MarR family; Region: MarR_2; cl17246 443906008588 Transport protein; Region: actII; TIGR00833 443906008589 Transport protein; Region: actII; TIGR00833 443906008590 3-ketoacyl-(acyl-carrier-protein) reductase; Provisional; Region: fabG; PRK05565 443906008591 classical (c) SDRs; Region: SDR_c; cd05233 443906008592 NAD(P) binding site [chemical binding]; other site 443906008593 active site 443906008594 mycofactocin system transcriptional regulator; Region: mycofact_TetR; TIGR03968 443906008595 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 443906008596 putative septicolysin, cholesterol-dependent cytolysin family and related proteins; Region: septicolysin_like; cd12208 443906008597 oligomer interface [polypeptide binding]; other site 443906008598 Alanine dehydrogenase [Amino acid transport and metabolism]; Region: Ald; COG0686 443906008599 Alanine dehydrogenase NAD-binding and catalytic domains; Region: L-AlaDH; cd05305 443906008600 hexamer interface [polypeptide binding]; other site 443906008601 ligand binding site [chemical binding]; other site 443906008602 putative active site [active] 443906008603 NAD(P) binding site [chemical binding]; other site 443906008604 Transcriptional regulators [Transcription]; Region: Lrp; COG1522 443906008605 Winged helix-turn-helix DNA-binding; Region: HTH_24; pfam13412 443906008606 AsnC family; Region: AsnC_trans_reg; pfam01037 443906008607 Trimeric dUTP diphosphatases; Region: trimeric_dUTPase; cd07557 443906008608 trimer interface [polypeptide binding]; other site 443906008609 active site 443906008610 ABC-type cobalt transport system, ATPase component [Inorganic ion transport and metabolism]; Region: CbiO; COG1122 443906008611 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 443906008612 Walker A/P-loop; other site 443906008613 ATP binding site [chemical binding]; other site 443906008614 Q-loop/lid; other site 443906008615 ABC transporter signature motif; other site 443906008616 Walker B; other site 443906008617 D-loop; other site 443906008618 H-loop/switch region; other site 443906008619 Transcriptional regulators [Transcription]; Region: FadR; COG2186 443906008620 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 443906008621 DNA-binding site [nucleotide binding]; DNA binding site 443906008622 FCD domain; Region: FCD; pfam07729 443906008623 Gluconate kinase (GntK) catalyzes the phosphoryl transfer from ATP to gluconate. The resulting product gluconate-6-phoshate is an important precursor of gluconate metabolism. GntK acts as a dimmer composed of two identical subunits; Region: GntK; cd02021 443906008624 AAA domain; Region: AAA_33; pfam13671 443906008625 ATP-binding site [chemical binding]; other site 443906008626 Gluconate-6-phosphate binding site [chemical binding]; other site 443906008627 fructuronate transporter; Provisional; Region: PRK10034; cl15264 443906008628 H+/gluconate symporter and related permeases [Carbohydrate transport and metabolism / Amino acid transport and metabolism]; Region: GntT; COG2610 443906008629 pyridoxamine-phosphate oxidase; Region: pdxH; TIGR00558 443906008630 Pyridoxamine 5'-phosphate oxidase; Region: Pyridox_oxidase; pfam01243 443906008631 Pyridoxine 5'-phosphate oxidase C-terminal dimerisation region; Region: PNPOx_C; pfam10590 443906008632 Formamidopyrimidine-DNA glycosylase [DNA replication, recombination, and repair]; Region: Nei; COG0266 443906008633 N-terminal domain of the actinomycetal Nei2 and related DNA glycosylases; Region: AcNei2_N; cd08971 443906008634 putative DNA binding site [nucleotide binding]; other site 443906008635 catalytic residue [active] 443906008636 putative H2TH interface [polypeptide binding]; other site 443906008637 putative catalytic residues [active] 443906008638 Formamidopyrimidine-DNA glycosylase H2TH domain; Region: H2TH; pfam06831 443906008639 coenzyme F420 hydrogenase, subunit alpha; Region: frhA; TIGR03295 443906008640 Zinc finger found in FPG and IleRS; Region: zf-FPG_IleRS; pfam06827 443906008641 Short-chain dehydrogenase involved in D-alanine esterification of lipoteichoic acid and wall teichoic acid (D-alanine transfer protein) [Cell envelope biogenesis, outer membrane]; Region: DltE; COG3967 443906008642 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 443906008643 NAD(P) binding site [chemical binding]; other site 443906008644 active site 443906008645 Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408 443906008646 Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673 443906008647 Oxidoreductase family, C-terminal alpha/beta domain; Region: GFO_IDH_MocA_C; pfam02894 443906008648 NADPH-dependent FMN reductase; Region: FMN_red; pfam03358 443906008649 Predicted flavoprotein [General function prediction only]; Region: COG0431 443906008650 Glutathione-dependent formaldehyde dehydrogenase related proteins, child 1; Region: FDH_like_1; cd08283 443906008651 Threonine dehydrogenase and related Zn-dependent dehydrogenases [Amino acid transport and metabolism / General function prediction only]; Region: Tdh; COG1063 443906008652 NAD binding site [chemical binding]; other site 443906008653 catalytic Zn binding site [ion binding]; other site 443906008654 structural Zn binding site [ion binding]; other site 443906008655 Patatins and Phospholipases; Region: Patatin_and_cPLA2; cl11396 443906008656 2-deoxyribose-5-phosphate aldolase (DERA) of the DeoC family; Region: DeoC; cd00959 443906008657 intersubunit interface [polypeptide binding]; other site 443906008658 active site 443906008659 catalytic residue [active] 443906008660 M18 Peptidase Aspartyl aminopeptidase; Region: M18_DAP; cd05658 443906008661 Aminopeptidase I zinc metalloprotease (M18); Region: Peptidase_M18; pfam02127 443906008662 active site 443906008663 metal binding site [ion binding]; metal-binding site 443906008664 Domain of unknown function (DUF305); Region: DUF305; pfam03713 443906008665 Dienelactone hydrolase and related enzymes [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG0412 443906008666 Domain of unknown function (DUF4383); Region: DUF4383; pfam14325 443906008667 PIF1-like helicase; Region: PIF1; pfam05970 443906008668 AAA domain; Region: AAA_30; pfam13604 443906008669 Escherichia coli PhnB and similar proteins; the E. coli phnB gene is found next to an operon involved in the cleavage of carbon-phosphorus bonds in unactivated alkylphosphonates; Region: PhnB_like; cd06588 443906008670 dimer interface [polypeptide binding]; other site 443906008671 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 443906008672 ABC-type cobalamin/Fe3+-siderophores transport systems, ATPase components [Inorganic ion transport and metabolism / Coenzyme metabolism]; Region: FepC; COG1120 443906008673 ATP-binding component of iron-siderophores, vitamin B12 and hemin transporters and related proteins; Region: ABC_Iron-Siderophores_B12_Hemin; cd03214 443906008674 Walker A/P-loop; other site 443906008675 ATP binding site [chemical binding]; other site 443906008676 Q-loop/lid; other site 443906008677 ABC transporter signature motif; other site 443906008678 Walker B; other site 443906008679 D-loop; other site 443906008680 H-loop/switch region; other site 443906008681 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550 443906008682 ABC-ATPase subunit interface; other site 443906008683 dimer interface [polypeptide binding]; other site 443906008684 putative PBP binding regions; other site 443906008685 iron-hydroxamate transporter permease subunit; Provisional; Region: PRK10577 443906008686 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cl00462 443906008687 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550 443906008688 ABC-ATPase subunit interface; other site 443906008689 dimer interface [polypeptide binding]; other site 443906008690 putative PBP binding regions; other site 443906008691 Fe3+-siderophore binding domain FhuD. These proteins have been shown to function as initial receptors in ABC transport of Fe3+-siderophores in many eubacterial species. They belong to the TroA-like superfamily of helical backbone metal receptor proteins...; Region: FhuD; cd01146 443906008692 Periplasmic binding protein; Region: Peripla_BP_2; pfam01497 443906008693 siderophore binding site; other site 443906008694 Protein of unknown function (DUF998); Region: DUF998; pfam06197 443906008695 Predicted membrane protein [Function unknown]; Region: COG3371 443906008696 Copper resistance protein D; Region: CopD; cl00563 443906008697 Cytochrome c oxidase caa3 assembly factor (Caa3_CtaG); Region: Caa3_CtaG; pfam09678 443906008698 Integration host factor (IHF) and HU are small heterodimeric members of the DNABII protein family that bind and bend DNA, functioning as architectural factors in many cellular processes including transcription, site-specific recombination, and...; Region: HU_IHF; cd00591 443906008699 IHF dimer interface [polypeptide binding]; other site 443906008700 IHF - DNA interface [nucleotide binding]; other site 443906008701 30S ribosomal protein S14; Reviewed; Region: rpsN; PRK08881 443906008702 50S ribosomal protein L33; Validated; Region: rpmG; PRK00595 443906008703 50S ribosomal protein L28; Reviewed; Region: rpmB; PRK00359 443906008704 Ferric uptake regulator(Fur) and related metalloregulatory proteins; typically iron-dependent, DNA-binding repressors and activators; Region: Fur_like; cd07153 443906008705 metal binding site 2 [ion binding]; metal-binding site 443906008706 putative DNA binding helix; other site 443906008707 metal binding site 1 [ion binding]; metal-binding site 443906008708 dimer interface [polypeptide binding]; other site 443906008709 structural Zn2+ binding site [ion binding]; other site 443906008710 ABC-type Mn2+/Zn2+ transport systems, permease components [Inorganic ion transport and metabolism]; Region: ZnuB; COG1108 443906008711 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cl00462 443906008712 putative PBP binding regions; other site 443906008713 ABC-ATPase subunit interface; other site 443906008714 ABC-type Mn/Zn transport systems, ATPase component [Inorganic ion transport and metabolism]; Region: ZnuC; COG1121 443906008715 ATP-binding cassette domain of the metal-type transporters; Region: ABC_Metallic_Cations; cd03235 443906008716 Helical backbone metal receptor (TroA-like domain). These proteins have been shown to function in the ABC transport of ferric siderophores and metal ions such as Mn2+, Fe3+, Cu2+ and/or Zn2+. Their ligand binding site is formed in the interface between...; Region: TroA-like; cl00262 443906008717 Periplasmic solute binding protein family; Region: SBP_bac_9; pfam01297 443906008718 intersubunit interface [polypeptide binding]; other site 443906008719 Lipoyl domain of the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases. 2-oxo acid dehydrogenase multienzyme complexes, like pyruvate dehydrogenase (PDH), 2-oxoglutarate dehydrogenase (OGDH) and branched-chain 2-oxo acid...; Region: lipoyl_domain; cd06849 443906008720 E3 interaction surface; other site 443906008721 lipoyl attachment site [posttranslational modification]; other site 443906008722 e3 binding domain; Region: E3_binding; pfam02817 443906008723 dihydrolipoamide acetyltransferase; Reviewed; Region: PRK11857 443906008724 2-oxoacid dehydrogenases acyltransferase (catalytic domain); Region: 2-oxoacid_dh; pfam00198 443906008725 Pyruvate/2-oxoglutarate dehydrogenase complex, dehydrogenase (E1) component, eukaryotic type, beta subunit [Energy production and conversion]; Region: AcoB; COG0022 443906008726 Pyrimidine (PYR) binding domain of the beta subunits of the E1 components of human pyruvate dehydrogenase complex (E1- PDHc) and related proteins; Region: TPP_PYR_E1-PDHc-beta_like; cd07036 443906008727 alpha subunit interface [polypeptide binding]; other site 443906008728 TPP binding site [chemical binding]; other site 443906008729 heterodimer interface [polypeptide binding]; other site 443906008730 Transketolase, C-terminal domain; Region: Transketolase_C; pfam02780 443906008731 pyruvate dehydrogenase E1 component, alpha subunit; Region: PDH_E1_alph_x; TIGR03181 443906008732 Thiamine pyrophosphate (TPP) family, E1 of PDC_ADC_BCADC subfamily, TPP-binding module; composed of proteins similar to the E1 components of the human pyruvate dehydrogenase complex (PDC), the acetoin dehydrogenase complex (ADC) and the branched chain...; Region: TPP_E1_PDC_ADC_BCADC; cd02000 443906008733 TPP-binding site [chemical binding]; other site 443906008734 tetramer interface [polypeptide binding]; other site 443906008735 heterodimer interface [polypeptide binding]; other site 443906008736 phosphorylation loop region [posttranslational modification] 443906008737 histidinol-phosphate aminotransferase; Validated; Region: PRK02731 443906008738 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 443906008739 pyridoxal 5'-phosphate binding site [chemical binding]; other site 443906008740 homodimer interface [polypeptide binding]; other site 443906008741 catalytic residue [active] 443906008742 Membrane protein of unknown function; Region: DUF360; pfam04020 443906008743 PGAP1-like protein; Region: PGAP1; pfam07819 443906008744 Low molecular weight phosphatase family; Region: LMWPc; cd00115 443906008745 Low molecular weight phosphotyrosine protein phosphatase; Region: LMWPc; pfam01451 443906008746 active site 443906008747 adenylosuccinate lyase; Provisional; Region: PRK09285 443906008748 Lyase class I_like superfamily: contains the lyase class I family, histidine ammonia-lyase and phenylalanine ammonia-lyase, which catalyze similar beta-elimination reactions; Region: Lyase_I_like; cl00013 443906008749 tetramer interface [polypeptide binding]; other site 443906008750 Transcriptional regulator/sugar kinase [Transcription / Carbohydrate transport and metabolism]; Region: NagC; COG1940 443906008751 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cd00012 443906008752 Glycerate kinase [Carbohydrate transport and metabolism]; Region: COG1929 443906008753 Glycerate kinase family; Region: Gly_kinase; cl00841 443906008754 This family is most closely related to the GT1 family of glycosyltransferases. The sucrose-phosphate synthases in this family may be unique to plants and photosynthetic bacteria. This enzyme catalyzes the synthesis of sucrose 6-phosphate from fructose...; Region: GT1_Sucrose_synthase; cd03800 443906008755 putative ADP-binding pocket [chemical binding]; other site 443906008756 helix_turn_helix, mercury resistance; Region: HTH_MERR; smart00422 443906008757 MerR HTH family regulatory protein; Region: MerR_1; pfam13411 443906008758 DNA binding residues [nucleotide binding] 443906008759 Peptide chain release factor RF-3 [Translation, ribosomal structure and biogenesis]; Region: PrfC; COG4108 443906008760 Release Factor 3 (RF3) protein involved in the terminal step of translocation in bacteria; Region: RF3; cd04169 443906008761 G1 box; other site 443906008762 putative GEF interaction site [polypeptide binding]; other site 443906008763 GTP/Mg2+ binding site [chemical binding]; other site 443906008764 Switch I region; other site 443906008765 G2 box; other site 443906008766 G3 box; other site 443906008767 Switch II region; other site 443906008768 G4 box; other site 443906008769 G5 box; other site 443906008770 RF3_II: this subfamily represents the domain II of bacterial Release Factor 3 (RF3). Termination of protein synthesis by the ribosome requires two release factor (RF) classes. The class II RF3 is a GTPase that removes class I RFs (RF1 or RF2) from the...; Region: RF3_II; cd03689 443906008771 Zinc finger domain containing protein (CHY type) [Function unknown]; Region: COG4357 443906008772 CHY zinc finger; Region: zf-CHY; pfam05495 443906008773 replicative DNA helicase; Region: DnaB; TIGR00665 443906008774 DnaB-like helicase N terminal domain; Region: DnaB; pfam00772 443906008775 DnaB helicase C terminal domain. The hexameric helicase DnaB unwinds the DNA duplex at the chromosome replication fork. Although the mechanism by which DnaB both couples ATP hydrolysis to translocation along DNA and denatures the duplex is unknown, a...; Region: DnaB_C; cd00984 443906008776 Walker A motif; other site 443906008777 ATP binding site [chemical binding]; other site 443906008778 Walker B motif; other site 443906008779 DNA binding loops [nucleotide binding] 443906008780 50S ribosomal protein L9; Reviewed; Region: rplI; PRK00137 443906008781 Ribosomal protein L9, N-terminal domain; Region: Ribosomal_L9_N; pfam01281 443906008782 Ribosomal protein L9, C-terminal domain; Region: Ribosomal_L9_C; pfam03948 443906008783 30S ribosomal protein S18; Reviewed; Region: rpsR; PRK00391 443906008784 Single-stranded DNA-binding protein [DNA replication, recombination, and repair]; Region: Ssb; COG0629 443906008785 SSB_OBF: A subfamily of OB folds similar to the OB fold of ssDNA-binding protein (SSB). SSBs bind with high affinity to ssDNA. They bind to and protect ssDNA intermediates during DNA metabolic pathways. All bacterial and eukaryotic SSBs studied to date...; Region: SSB_OBF; cd04496 443906008786 dimer interface [polypeptide binding]; other site 443906008787 ssDNA binding site [nucleotide binding]; other site 443906008788 tetramer (dimer of dimers) interface [polypeptide binding]; other site 443906008789 30S ribosomal protein S6; Reviewed; Region: rpsF; PRK00453 443906008790 tRNA adenylyltransferase; Region: tRNA_CCA_actino; TIGR02692 443906008791 Nucleotidyltransferase (NT) domain of ClassII CCA-adding enzymes; Region: NT_ClassII-CCAase; cd05398 443906008792 active site 443906008793 NTP binding site [chemical binding]; other site 443906008794 metal binding triad [ion binding]; metal-binding site 443906008795 Probable RNA and SrmB- binding site of polymerase A; Region: PolyA_pol_RNAbd; pfam12627 443906008796 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 443906008797 Zn2+ binding site [ion binding]; other site 443906008798 Mg2+ binding site [ion binding]; other site 443906008799 integral membrane protein MviN; Region: mviN; TIGR01695 443906008800 MurJ/MviN, a subfamily of the multidrug and toxic compound extrusion (MATE)-like proteins; Region: MATE_MurJ_like; cd13123 443906008801 thioredoxin-disulfide reductase; Region: TRX_reduct; TIGR01292 443906008802 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500 443906008803 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 443906008804 TRX family; composed of two groups: Group I, which includes proteins that exclusively encode a TRX domain; and Group II, which are composed of fusion proteins of TRX and additional domains. Group I TRX is a small ancient protein that alter the redox...; Region: TRX_family; cd02947 443906008805 Thioredoxin-like; Region: Thioredoxin_8; pfam13905 443906008806 catalytic residues [active] 443906008807 Aspartate/tyrosine/aromatic aminotransferase [Amino acid transport and metabolism]; Region: COG0436 443906008808 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 443906008809 pyridoxal 5'-phosphate binding site [chemical binding]; other site 443906008810 homodimer interface [polypeptide binding]; other site 443906008811 catalytic residue [active] 443906008812 D-alanine--D-alanine ligase; Reviewed; Region: ddl; PRK01372 443906008813 D-ala D-ala ligase N-terminus; Region: Dala_Dala_lig_N; pfam01820 443906008814 ATP-grasp domain; Region: ATP-grasp_4; cl17255 443906008815 ParB/RepB/Spo0J family partition protein; Region: parB_part; TIGR00180 443906008816 ParB-like nuclease domain; Region: ParBc; pfam02195 443906008817 ATPases involved in chromosome partitioning [Cell division and chromosome partitioning]; Region: Soj; COG1192 443906008818 ParA and ParB of Caulobacter crescentus belong to a conserved family of bacterial proteins implicated in chromosome segregation. ParB binds to DNA sequences adjacent to the origin of replication and localizes to opposite cell poles shortly following the...; Region: ParA; cd02042 443906008819 P-loop; other site 443906008820 Magnesium ion binding site [ion binding]; other site 443906008821 16S rRNA methyltransferase GidB; Reviewed; Region: gidB; PRK00107 443906008822 rRNA small subunit methyltransferase G; Region: GidB; pfam02527 443906008823 jag_K homology RNA-binding domain. The KH domain is found in proteins homologous to the Bacillus subtilis protein Jag, which is associated with SpoIIIJ and is necessary for the third stage of sporulation. The KH motif is a beta-alpha-alpha-beta-beta...; Region: jag_KH; cd02414 443906008824 R3H domain found in proteins homologous to Bacillus subtilus Jag, which is associated with SpoIIIJ. SpoIIIJ is necessary for the third stage of sporulation. The name of the R3H domain comes from the characteristic spacing of the most conserved arginine...; Region: R3H_jag; cd02644 443906008825 RxxxH motif; other site 443906008826 putative inner membrane protein translocase component YidC; Provisional; Region: PRK01315 443906008827 membrane protein insertase, YidC/Oxa1 family, C-terminal domain; Region: yidC_oxa1_cterm; TIGR03592 443906008828 hypothetical protein; Provisional; Region: PRK14378 443906008829 Ribonuclease P; Region: Ribonuclease_P; pfam00825 443906008830 Ribosomal protein L34; Region: Ribosomal_L34; cl00370